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<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDA1</accession>
    <name>A0ABM0JDA1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Short-wave-sensitive opsin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005091056.3">
        <property type="nucleotide sequence ID" value="XM_005090999.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862769"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="31"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005091056.3"/>
        </source>
    </evidence>
    <sequence length="345" mass="39031" checksum="8CCEDACB87292C3F" modified="2025-10-08" version="1">MKLIDDNTAQFWFVVLKCGFYEAFSAFGIVTNIISLVVFYRMGFRETVNVSLFGLTLSDLGSLLVLFWMGICYNPLFTYSDVEFDTLSIVYLSGGWPKLYLTRVTSWITAFVAFERCLCVAMPLKVKQAITPRIAFAVNLSLAIMVGASLPPVYATTGLDWTWFPARNKTLLGLSFTEDRLEVYDVVVGFNLFFTLGSFLIVIVCTFVLVAQLKWKTKWRQSATKAQNTNTSSRDQKISTMVTLLSALFVVCLLPSTAVFLAMILAPEFNKGKGYHNMFTIVWAVCHLFEAANSSLNIFVYTHMSSKFRRCLYAMFRTRLSVDETLTQSMAVFRSEYQANSSVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JED8</accession>
    <name>A0ABM0JED8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptosomal-associated protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091799.3">
        <property type="nucleotide sequence ID" value="XM_005091742.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850305"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF1">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="78"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005091799.3"/>
        </source>
    </evidence>
    <sequence length="136" mass="15066" checksum="35D5527E324DD8E6" modified="2025-10-08" version="1">MPAVLVKFESFAKSKMEYMSPPAESSVQRATAPSSVPNDSPSPWSSMQSSPDRDSPKHVPTENDVPQIQARAQKDVVSDAEAAELSATLENLKSLALDISTEQDSQLDMIDRVTQSVDRADYRQKELDKKMNKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEI1</accession>
    <name>A0ABM0JEI1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="10">3.4.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Imidodipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proline dipeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101850138</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline</text>
            <dbReference type="Rhea" id="RHEA:76407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:195196"/>
            <dbReference type="EC" id="3.4.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005091896.1">
        <property type="nucleotide sequence ID" value="XM_005091839.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850138"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005091896.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="56531" checksum="8969D461B7B6D221" modified="2025-10-08" version="1">MASGKAEPAFCRGDHTLKVPMELFQQNRQRLCERLRANKNIPKGAIVVLQSGVSETRNDSDNEPLFRQESYFHWTFGVEEPDFYGAVEVDTGRSILFPPNLPDAYAVWMGRLLTRDDFKRLYAVDEVVFSDKMAEALKEKSPSVLLTLYGLNTDSGKYSREAVFEGIANFTVNNEWLHPDITECRVFKTDLELQLLRYCNRISSEAHIAVMKAVRPEMFEYQAESLFHHYCRFNGGLRMVSYTCICGSGHNGSVLHYGHAGAPNSKQIQDGDMCLFDMGGEYYCYTSDITCSFPANGKFTPDQKAVYEAVLAASLAVMKAVKPGVSWVDMHKLAERRILEHLVALGALRGDVDRMMEVRLGAVFMPHGLGHFMGIDTHDVGGYPEGTERIDQPGLRSLRTVRTLEPRMVLTIEPGCYFIDALLDGALRNEQQREFLVEDVISRLRGFGGVRIEDDIAITEDGMELFTCVPRTVEEIERVMAAARPTHQPLPQQKGAQEQQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGZ0</accession>
    <name>A0ABM0JGZ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentatricopeptide repeat-containing protein 2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101852458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093464.1">
        <property type="nucleotide sequence ID" value="XM_005093407.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852458"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034629">
        <property type="entry name" value="PTCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14700">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14700:SF0">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005093464.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40671" checksum="63F16B24DAFFEF35" modified="2025-10-08" version="1">MVVKFLRITPAILRRLNHYIPRSTVCRTLLSDPSLKIDHFAKRRIFQVDLLGKDGKAKLAKKLQTMSSSDEARHATHDIVDLLHCADVEDIPLINNLILLVSDPDVVQSRAFNFGVTLIRLYHFLNLPEEAHSVYSNPECLLLFQDATSHKVLMDLMYKNKLFTQVVEVYSMLKHFNIDCVTLVLGALYHLNTPDCLEKAQDIVKDVCQHHVLSRRAIIFVALLSLNQNEPDFALEILKQSKDSVLVTNVKIMCLSRQGDLKSTFAQLEEAVEISKNITRPFAARLYSDTMGEVRKAVKLHGLPEDAMKLERLEQQLSYRGVLSIQVTTSLIERIIPGVEYFRKDTGKPPIINNSQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIC2</accession>
    <name>A0ABM0JIC2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sperm-associated antigen 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101860638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094300.1">
        <property type="nucleotide sequence ID" value="XM_005094243.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860638"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026124">
        <property type="entry name" value="Sperm-assoc_Ag8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15510">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15510:SF5">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22584">
        <property type="entry name" value="CFAP143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005094300.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24751" checksum="3C3F52ECE7B5A22F" modified="2025-10-08" version="1">MDAMNARVGISLANDGRNEIRVNNSAGRCLLENWVEERANVDRDPPLDREYNMLERAGFLRSGHNGLITIEDSAKAEKLTTVRATYTPPQVDQTRHVGKRKELMEQAFAQAVCEDMEKEKERKIAEDMKGIMCTVFMKDYTKEFPKTEPEQTLDHDYVSEQPVTFWSEHRDKIHGTTQVKTKDTAFRKNDAFSKPIGEYWDEAKPVELDQYPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ01</accession>
    <name>A0ABM0JJ01_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846124 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094762.1">
        <property type="nucleotide sequence ID" value="XM_005094705.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846124"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094762.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16765" checksum="4A0603D1B5506C1A" modified="2025-10-08" version="1">MSLAGDGSREYNAETGNAVELSAAVKNFKQSEALESVDGFDRDLMTLQDQILNLSVRTHMLEVDLATLFSPDLILELEKMDQSCVECTLDLEKMACEEFSSLNADAEPPVSQTDSLLPLDQPNEVNDEKSNNVQCMSDKSALDVDDADEDKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJL0</accession>
    <name>A0ABM0JJL0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase PPP1R11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein phosphatase 1 regulatory subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101859394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095168.1">
        <property type="nucleotide sequence ID" value="XM_005095111.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859394"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005095168.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19204" checksum="D7BB7EDB2ED16855" modified="2025-10-08" version="1">MAEAQPGTSTQPVDSGTATETVVVDKSEEQESPPVLHLRLQKPKNDHKVKWSTDTVDNEFMGKKKSKCCCIYEKPKVFGESDSSSSSDDSDDEGCTPHCRGHKKKCYQHSPHPHNNGSSHDHAESGGQHRDDAGPSRACPYPASPRMACCPKDGLTCSLPEAQQLAQPSEEGGEGQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKC2</accession>
    <name>A0ABM0JKC2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095736.1">
        <property type="nucleotide sequence ID" value="XM_005095679.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852232"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005095736.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="24331" checksum="8FE7565367E1E27C" modified="2025-10-08" version="1">MYYTADLLLGERPWLNQTSACTFHQPGASSDDDTDEPIDENDNNNDDGGDAGSSQTPDQSGGESSAAAAEEGVTFQEAAAGSEGNWTSLQEYVGKYENDFFGNLSIDLDPLTQFLKLSYGKVGQVEFTVRETETRLRGRFTGLVEIYNNQDACNEKIQFHLSAAGSVTGLAFLMDDDDGYVTFTRAGYASGWSNGGQASMSSAAVKSVLLTCCSVIAFCFFNVQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKF3</accession>
    <name>A0ABM0JKF3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iduronate 2-sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095812.1">
        <property type="nucleotide sequence ID" value="XM_005095755.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850640"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16030">
        <property type="entry name" value="iduronate-2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035874">
        <property type="entry name" value="IDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045350491" evidence="7">
        <location>
            <begin position="24"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005095812.1"/>
        </source>
    </evidence>
    <sequence length="701" mass="80882" checksum="0D34EE020341DE88" modified="2025-10-08" version="1">MSSMDFLQHVISFICIIFAKASCESRGYFRANNGRPNVLFIVVDDLRPTLGCYGEPILKTLNIDNLASKSLLFEQSFVQQAFCGPSRTSFLTSRRPDTTRLYDLHSYWRTHAGNYTTLPQHFKQNGYITQSVGKVFHPGRASNFSDDSPYSWTNTPYHPSTQKYKMAKVCPNPDGTLGMNIVCPVNVQKMPEKSLPDIQSAEFAVEFFKNLSSSKDNRPFFLAVGFHKPHIPLKYPKEYLDLYPLSEIELAKHHTFPPRMPLVAWNPWTDLRERDDVQRLNISFPFGPVPDQYQRLMRQSYYAATSYMDAQVGQVLSAMEEAGYADNTIIVFTGDHGWSLGEHQEWSKYSVFNVATRVPLIMYLPGLTHRRHQIGDEKIFPFLNPFEHRRDVNSETKLAFFSNERKLHVKAIPNVTDEKLQTTEIFKTLEEVSYSSESLLRRGFDNIAQLTEERVKRSQSKFKAATGFRTSALVEHVDLFPTLAEAVGLPMLPLCPINPFKVLLCTEGTSLMPLIRNITSPERSHVKTSIVENNHHQRDDNRPVMTHRKSQKEFITNAININDGVLEFTSELNALHIAAKNCSPSFRPVFRSDLEFEWKKAAFSQFPRPSVLPQENSDKPLLRDIRIMGYSMLTPQFHYVEWVGFDHKSYKIKWNDIYGRELYLRDLDPYEISNMAIFEKCHSLLRILSSRLHKGWRYARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JL65</accession>
    <name>A0ABM0JL65_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 37-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101845682</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005096298.1">
        <property type="nucleotide sequence ID" value="XM_005096241.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845682"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="36"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="750"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="777"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="835"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005096298.1"/>
        </source>
    </evidence>
    <sequence length="966" mass="107855" checksum="565DBF8AEC4315C9" modified="2025-10-08" version="1">MATYTGLSRCGVFHDQTHLKNCLIALNDQRNLSQFCDVVLKVCGTQIYAHSNVLAAASPYFGSILGIGADCPRGFSQKQPQIIEIHIDSHDGDGGYGEAVSKVVEFMYTSNITLKATLITQVIEIGKIMRMDTLLQFCDMFQNGEDSNDPKTIGTCTTGLEEIAQLLGSRARTVKKADAFTETEKSVFDKIRPDLNSVSSPQISTTLESSSELILLKQQEAQILEKSSNLPAVTEDDSQKNETPTNASQDIDDELPISTNIGFESMDQDQNDASLLLAISNVRPPLGVTDASKPLQGTCEPSGMTDNPDPNPRMTTPEPEKVDESSLLKKSDSGPEKGLSDISIKTVMMIASIKEETSANTFDKNVPSCSSNENATTTNKSDSEMSQRISQLGDSRVKSQKGIDLDEISDLVQFYHVDTGLYAGANSNSKPPSRSRGRGRGRGRGRGKRRGRGRGPGRPRKVVEEPESDPEFEDFIERLERGDDVLHNSDDESKRTKSMKESESTSSAQPVGSTLVGEAFLKCDVVKELPMETNIVAKEGHSLQWKSKRVRSKPSQLKKDYVMHSLGKKSRRPHKETKQEETSEPNQVALPRETANIVVQNSSKSGLKFVCEKCEFASHVFKEYRQHLKIHPETDPKYFLCTKCDFKTTKAREYKLHKYKHMSEEFICSFCEHQSENHQAYKEHSVKHEGALPYFCTECESRFRTKTQLMAHRPKHQLVKPFVCAICSAGFKWKHALKNHMITHNPTKDHLCDVCGYATAHKSQLKAHKLIHSGQLFKCPVTGCQFEAIKRQNLKYHMVTHTHEKPHQCEICGQSFSLIKNMRRHMLLHSDSRRYSCKVCSFNTTRYDKLKEHHYKLHNIGEQPGGVKKTYRPKPPAEESIALISPDVTYVASEGIQINADGTISEEALQQIAQLANAQNSSIVDIQSTSIDISEQSTQESSGYPIIATVQYTDGQEVQYIAEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLG6</accession>
    <name>A0ABM0JLG6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADAM 17-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101847717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096483.1">
        <property type="nucleotide sequence ID" value="XM_005096426.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847717"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14246">
        <property type="entry name" value="ADAM17_MPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032029">
        <property type="entry name" value="ADAM17_MPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF6">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16698">
        <property type="entry name" value="ADAM17_MPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047042043" evidence="4">
        <location>
            <begin position="23"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="6">
        <location>
            <begin position="225"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="5">
        <location>
            <begin position="468"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005096483.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="82520" checksum="D4967782B8DEC3D2" modified="2025-10-08" version="1">MFLFAKIFFITIAYLTLIDVLACEANIHDKVSYHELIRGSETSVKTRIRRSVDQSKDMMNDLTKEFHFTAYNMTFVCHMTPRTGFFSPKFKLKVYGADGVPREFGFRHDQVYVGSCDGDPQSEIRGTFKGDIFTGSLFYKGQMYGIEDAARHIPSVPISEQMIVYRNADMKWNKENKDNDGGRFCGNTDGFSADPVADKEEIVVDKIVQDHHSGRKKRATVPTWDTCRIVAVADYKFFREIGKSDVYDTALHLAGVMDRVDNIFRRTEFNVNGVPYTGMGFEIAEMRIFEAPTIGFNKDTGSWEAQTLLQTFSTDLTFKSYCVAHLFTHQSFQGNTLGMAYIASDRNEDIGGICSPESYIRSLQARASENTGFTSTRNGYGETVLLQQSDLVTAHELGHNWGSNHDPSSGSCSPSDIFGNGKYIMYAISVSGYDSNNFLFSTCSRNAIGRVLLTKGQGCFTARATDESLICGNGKIDSGEECDAGFLGRLNLDPCCNNDCTLTRTSTCSPGNHECCVNCQLASQGLLCRADSGIDCQKSAYCTGSSLVCPASEDKDDGDECLDEGKCEAGECLPFCQARNLTSCACSDLANSCQRCCRTGEGAECVPYDNNHPLPDGRPCVAGYCEGAVCQASSESTIQRLFSIFDNLDVNSVVKFFRDNLVGCVIVFSLILWIPASIAVSCMDRRRRKRLNRSEEIEIRRDRELLFDEDGRKVGPAQSSVPQNGTTSPRYRTLNFTDLGGFGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM81</accession>
    <name>A0ABM0JM81_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101846575</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005096981.1">
        <property type="nucleotide sequence ID" value="XM_005096924.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846575"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="131"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="11">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005096981.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="45089" checksum="22B1A7AD723A792C" modified="2025-10-08" version="1">MDKEIYDLSGGVENQVVLLCRISNKRSSSHESVNKLSFNCWDFEYIKTNIPGAGCEADLFSEQYAGCSCEGTCSSHSCSCLQRFGSPYTKNGKICMNKQNSELSKPVLECGNSCKCGTDCPSRVVQKGVTRSFCVFPTGQKGFGLKLPEGLCDNKIPAFTFVCEYAGEVIGHQEAKKRVLENEKGKKDNYIIALREHVGAQEKCTYFDPSKLGNAGRFINHSCDPNLIMVPVRVNHSVPRLALFARRDIMAGEEFTFDYSGKSTFFSTSLKEATLSNSTGTHIGLTLNEPNVDSRTVDEPPVKKSKLCSPSSLEPEDVEDVYNNTEGSGVAAVSLSVQKPGDPSPLLHCSRTVEVSAVPGSSSNTCSEVDSPKQADTFVDSENSGHFKLCFCGSENCQKYLPFDERLLSDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMC2</accession>
    <name>A0ABM0JMC2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 585B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097052.1">
        <property type="nucleotide sequence ID" value="XM_005096995.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864138"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="450"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="593"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="623"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="697"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="732"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="760"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="788"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005097052.1"/>
        </source>
    </evidence>
    <sequence length="890" mass="99957" checksum="73D0DF1B470718E5" modified="2025-10-08" version="1">MDKVRFRHGEPSGTFCVAWGCSNRQKTGDGRKFHRFPKDALRRKKWKAALKRDAFEATDHSRICSDHFEKESYNQSGRLKDTAVPTIFNFPDNMCLTMVVNQGSQVSPLNKGRGCQSSHKTMRKIDISQIFSEAVVSVDEVRRAAETSVCTVGVQTDPVYILPMEDADLMTFGTDRGLSARLTLDSARRPPGTSQGLVRHHCRICGAAFVGQLQLKLHQWIHQMAQPSSQRRRAASMSQRKLATPGSEKKNEGASLSRVLKGVNNGAEGSAADADLGAMEITVLSDRRVITPWQTGQENVPVVELPRAVKQTGTLGIKSGIIVGKKRPVGKLQRSLLKDRLPREGGQKRSDSEDNTPKKCPVCGEMFVKPAALRIHLSEHLYYDIHRGQVLIRGAVLPNTNGTGVDVMEQTSAGEVLAGEQEGPPPDGLAKSNGPVPYSHSDVKGSEFSYVCTLCNVGFMRKKQLCAHRHSEHSSIKSVYKDKRLVLKSPSSIRRKSNMCEICGEVFKSLYSMKIHVLRHKENLYQGNICLNDFSTSDVLTVHKKLQEPKDLEAQPAEKSELKKFVCDVCGKTVKSMKQLQSHMLRHTGGDIYTCRVCKEKFSSLKLLKTHQAEQGHVVDKPFICEVCGTAYSHIFSLKRHHFVTHVKNKDKEERVKQGVKKTRVEGSFPCEYCGKVFDFKDKLQCHVGKHTGEKSYKCEICHKTFCYPSSLSFHKRKHRETKVKEKLKVRVTCEYCHKVFCSQQILASHIKYHTGENLHTCEICKKSFAYKASFVLHKRSHAGERPYKCDLCPQRFLRPYNLRCHYRIHTGEKPYPCQICGQKFRQQGDRNSHQKRHATQAAKASNNVSSSTAAVQTQVEAQVPATIQIQVLSQQDNETATSVISVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN54</accession>
    <name>A0ABM0JN54_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097585.1">
        <property type="nucleotide sequence ID" value="XM_005097528.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846071"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005097585.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21603" checksum="81C6CAC2507AB46B" modified="2025-10-08" version="1">MENGAGNEKRPSDLSHVAMGSNMNLFEGRGVDPKSKRFPHCIVWTPIPCLTWLFPFIGHMGICTTSGVIRDFAGPYFVSEDDMAFGQPVKYWQLDVSKAINGKDSWDRSVAKASEEYNHRMHNLCCDNCHSHVAMALNLMNYKGSSRWNMVNLCFLMMVHSRYISVCGFLKTWLPFLLMVGVIITVVLVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNE0</accession>
    <name>A0ABM0JNE0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L15, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101847107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097758.1">
        <property type="nucleotide sequence ID" value="XM_005097701.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847107"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="7">
        <location>
            <begin position="90"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005097758.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33233" checksum="6EC92AE976DFA1F9" modified="2025-10-08" version="1">MASKVTERALSLIKSLPRVALTNIKDLPSAKRKKTGKPAGQKKKGRGDKGQGARNTWDPLGYEGGQSPLINNVPLERYYGKYALRRQYPPISLLELQRLIDLNRVDISRPVDVTAICNSRLYSLDVAKNHFGFHLTEEGCDSFDAKINLEVQWTSELVIAAVEKSGGTITTRYYDPQSLGAVFDPQTFFQKGLPIPKCKLPPQDALAYYSDPNARGYLADPEKILEARERLAQKYGYKLPDLSSDPVKDLLLMRKDPLQLFYGLEPGWIVNLRDKCVLKPQDEDYRRYYNTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPK0</accession>
    <name>A0ABM0JPK0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC101851127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005098538.1">
        <property type="nucleotide sequence ID" value="XM_005098481.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938065.1">
        <property type="nucleotide sequence ID" value="XM_013082611.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825694.1">
        <property type="nucleotide sequence ID" value="XM_035969801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851127"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005098538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012938065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035825694.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45721" checksum="13B849DC52E116C3" modified="2025-10-08" version="1">MKVKWKEFLGKLGLRSQSPPGGVFVSVNVMKSMRSPPGRNYHTSRVILRVSIWTCLFLVLFFFIVYTILLAYVDDQFHPALISPPGIVYHKRLHGKLNVDDVKSGNAGARVDQSKEVLWNSSQFYNDEPMPQCKWQTLFRLLVATSVQNKDRRDRIRETWCNPKAFGFPKHSWHCIFLVGQAKSEKLKSELYKESSQHQDMLVGNYVDTYRNLTLKIIHGFNWSINFCPSAYVVKTDDDCFVNAGLLHRFLLYHNQKTIDLYVGSVVQDREKLRVVRGDQKWSVPYSDYPEKYYPPYASGIGYVMSSDVAKRLVSGSMYIKPFANEDAYVGVVLSRIGVQFTSSSRFMLSSGGLSLCNFMYVLMLHDVSVERQRELMKKALAAPEHCKHHKPVETWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQG5</accession>
    <name>A0ABM0JQG5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101851190</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099148.1">
        <property type="nucleotide sequence ID" value="XM_005099091.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851190"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058831">
        <property type="entry name" value="LolA-like_dom_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902:SF1">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25898">
        <property type="entry name" value="LolA_2nd_metazoa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045669968" evidence="2">
        <location>
            <begin position="20"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="756"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099148.1"/>
        </source>
    </evidence>
    <sequence length="995" mass="109542" checksum="CF45BA2EF4B30E70" modified="2025-10-08" version="1">MAVGVQLFISAVSLAMVRGLSPYCTPAQNTIGKPLPNLSMKSFRTEIAGKNIIKKYSQYSRETFDQPSKRLAIYTQTPPDNEYTAITDGVEQRMIVIKNRECQVLSGAAIDAPFSANDGTSTFSTTSVLQLGGKTTYVGQTTVRGIKVDHWTKCAYISASNSTVTFDIYLSDPDWSMPSGLPIPTPVRYEMKGKTGSGTDLQDEHQVFDYINFELLDTKKYESDFEIPVGVYCPGVSATKSPPQMPRSVSYMSELKNIRISHVSLTKVLYDTDDQFSREDKLNLPDNTFYGDPKNAQSSSLTNVRDFAEGVKYEVREDGSCVSSVFNALVKAKGNDGLPYLDDESVSPQDGYVHMKTVQDFFHADGGHFNYDKAAEVRGIKSDMFTKNVNSTYGDDGVHSQVQLYFSANQTTQSTYGASHLVESQLLRRATMNQNLPMIEDIYDFIPNPQYSQNPFDIRSCFNDSQKLNFHMVLRGPNMSSSDVSVVGRVLSRKLAVMAQVSRARIHWDQVVYEDGLTNVMGTLMDRGPARDNYGPATGKMVDLSKVPISNQKQVVQLPTDDSTMASLSPDFCARVCNGQKYQTTVTKCDSFDFCPGKCLFYWGHNQGDVTKDYYLKPASGCNHYHKLVNVKPEPDLKKAWSLLRSAVFSNQVNITINGSDSGLNHTYTAFSVRDLSTELQGVTNVESPLHNYFILPNADISTGETRTANDEDECATACSNSLLPRCESFTYCNTKQKCLIREEKPKVQNSPAIDCKTYVRTYLAYFEKLPGKSVLSELAAKTFTTVTDSEECARKCKNEKSFWCESFDFCSDNGGTCALSKTHYYTTRPNSVKKSPTCTHYSRNYLFDYQKSPSPVQNPGNTTTALHDVSLSECAASCSRSHGACRTFYFCPDTKSCLISGPSDSAQVSGAQSGFCDVYNQNRGVSSASALSGTGRGGGGGSDGYSQASMAGLGVGMIVLGVLLAVLGLFLAAHLKIGRMGRADNSFSMEELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQK1</accession>
    <name>A0ABM0JQK1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Serine/arginine-rich splicing factor 6 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101847657</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099219.2">
        <property type="nucleotide sequence ID" value="XM_005099162.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847657"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12337">
        <property type="entry name" value="RRM1_SRSF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12600">
        <property type="entry name" value="RRM2_SRSF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047190">
        <property type="entry name" value="RRM2_SRSF4/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="111"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005099219.2"/>
        </source>
    </evidence>
    <sequence length="270" mass="31166" checksum="FBA22B7E38C70B30" modified="2025-10-08" version="1">MGTRVYIGRLSYHAREKDIDRFFRGFGRIRDIMLKNGYGFVEFDDYRDADDAVYELNGKELCGERVSVEHARGPRSDDSFRDRGFRGRRGGGGGGGRRDNSRYGPPTRTDHRLIVENLSSRVSWQDLKDYMRQAGEVTYADAHKKHRNEGIIEFATSSDLRNAIDKLDGTEINGRKIRLLEDKPRRNSRSRSRSRSRSRRSRSRSGSGSRSRSRSRSRSESKDKKSKSRSASPRKKSVSRSRSRSHSRSRTPEKERENGDQEPDDRNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRI6</accession>
    <name>A0ABM0JRI6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Caspase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101863589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099863.1">
        <property type="nucleotide sequence ID" value="XM_005099806.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863589"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF232">
        <property type="entry name" value="AT03047P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="9">
        <location>
            <begin position="51"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="8">
        <location>
            <begin position="199"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005099863.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33182" checksum="67C1AABA319191EF" modified="2025-10-08" version="1">MDMDTVDALGEPTESDVVDARGQPGGGSRVGAAAQKESDFVADMYNMKHKNRGIAVIFNNKVFHRRLQMGDRQGTDVDCENMYNLLSTMGFDDIRTFHDSTVKEMRQEMQQVSKEDHTQNDCFVCVILSHGKEGYVFGQDDKVPIDELVLPFKGNNCPSLGGKPKLFFIQACRGTDLDSGVEVSDAAPDEEESMEEEVVMRRIPTEADFLMAYSVVPGYFAWRNSSRGSWFVQAIYDVFSEHWEKMDVLSMMTRVNKKVAYDFPSNASKEFMNRKKQIPCITSMLTKDVYFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRR2</accession>
    <name>A0ABM0JRR2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF-hand calcium-binding domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100040.1">
        <property type="nucleotide sequence ID" value="XM_005099983.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862802"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015070">
        <property type="entry name" value="EF_hand_DJBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF2">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08976">
        <property type="entry name" value="EF-hand_11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="466"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="666"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="882"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="918"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1116"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1370"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1484"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1298"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1300"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1333"/>
            <end position="1349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005100040.1"/>
        </source>
    </evidence>
    <sequence length="1551" mass="180089" checksum="8919E93880785A2D" modified="2025-10-08" version="1">MAQVMPSLRPDSQGVQFTARAALRTRESIGRSPLSRSGRASSIGSLASSGHLAGEGGEVVVATSQPKMSVIEVEAALREKVRSKFDNLRQAFKMYDVDENETVTKGEFRRVLESYCLPLTTEQFDGVVAKIDCVKGGTVVKYVDFLTKFYGGDASNKMRSVRSGPPAPREVNMDMIEKLLRDRVNGNLRSVVRGLQLFDYNMDGKIQRHELRRVLENYCFKFTDQQFDKLWLRYDFHHTGLVNYRDFLKRLGVNVKNSINAPTSDSAAGALKWPKMSSPSSTAGKVASSQLKSQQKEDEKLLKSLTFEQIEIEFRNRMKTNYLKLKKAFMTFDKHLDGYVSIDDLKNILNSFTLPMSDQLFVHLMEKCGVKASGRVAWEIFLEKFQNPVTVGNGQTLPIRPNHRIHPIMETQKIVDWDAIWNQLYKRIQSHYNSLKEAFLQMDKNRDGRVTKKEFRELIEKFTFRLDDRQFKELMSRVDPDQNSRVDYHTFLRLFEEKETKEGHKWLKSVHKYNDKPKPAIVAWETVEELLREKITYYWKDVSDWLTYHDRKGTGYMSKGTLKKIIDMQVLPVSDNHFENLISRCADFQDGKVNYMEFIERLGVDVSPGDVVGLSSQIMYGSGQAEMKRQVDLMNRHNQMAMSQCYRTSEMTADEVIARFKDKMAQLSPALRKAFLTYDKKNKGRITKAQFRAILSDLGILMSDEQYSELMARLNLNNGHMQYMDFIMNFGDPRHSESLGIVSHMDNHRVNPIRGDERTMTALEVESKLRQKLRENFTNLRGAFYKFDDLHRGCLNKSSFRRMLDAFMINMNDDEYEKLCEKLGIVKGCRISYLEFLERFEQRDTAEGHKWLNSVHTYNETFPPKPLSAEEAHNLLGLKAYRQWKDLSKAFRTMDSKGNGIITKQELRDTLHKFTMPMEAEEFKKLWAKLDIDNKGFISHQDFLQRLGAREYAPGDDQGPSSNIISGNYRFLDEHNSLQQQRHEDITWNQANLTNNMPAIMVERQLRDKIRDSYQDFYTAFRKYDMRKLGSLTPDDIQKVLIEQNFFINDEQFFALLDRIGLPTDRSRINYSDFLKAFEDGRKSSYGRQPRDIRIDEFRKLNPQEAEKKLKERLEANIDDVTKALAAFDRDGSGKVPVPEFRRVLDLFCFILTDVQWKHIKSGLSIGPDQCVDYNDFLSSFISGEIDISDQYLQSLQNAFPPGPNPLVSVDEVAERVHEAVVSHYHNILRDFESIDYAKIGSVTAEDFREVLARHIMRMNDEQFERLWNVSPINTYGNLEYKQFLKVFSEDMPIMMDSGPVQSSANKTSAQNLAGQQGRPSTSMSQRPASRVSNRPFSRMSRSSSRSGRAATPLVNAESAERQVKDTVFRYWKEIQKRCRDMDVDNSGTISVTQFGDVLSQYGCLLPPPDFNDLAIKYDINENGRFHYSDFIRHFLLSVKPGEQRVLTNRDRMPAKKLYHPNGTIEEEGEENDAARRTKDCVGQNWKEMRREFRNVDQETKGLVTSEEFRRVLRMFNINLSENEFQQLQDKYDKNFTDWVNYNEFLKHHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSB8</accession>
    <name>A0ABM0JSB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C-type lectin lectoxin-Lio2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101847662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005100399.1">
        <property type="nucleotide sequence ID" value="XM_005100342.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847662"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="7">
        <location>
            <begin position="111"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005100399.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27678" checksum="909879B718B38B38" modified="2025-10-08" version="1">MGVRGDVPPQPQDGQSIHKYKKLYILTWICFIVTSLLVSSAAIVDIVQTVSSINQDQMSINIRGELSAVQEKFDNLEKKVSEVEDDATTPSKLKLCSHGSGCEQLTSRPEAMTHCYKVSDEKTTWADARKKCESLGGFLAEFHNHFTLEYVKRVVTSDTSRLWLGATDQGKEGIWTWVTSNRHLSVEDWDINQPNNLMYIEHCLEMDKRRRKSWNDIRCNSKLRYLCQRDGDNCQGWLEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTP8</accession>
    <name>A0ABM0JTP8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17 18">Pyrokinin-1 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 17 18 19" type="primary">LOC101851742</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101265.1">
        <property type="nucleotide sequence ID" value="XM_005101208.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939584.1">
        <property type="nucleotide sequence ID" value="XM_013084130.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939585.1">
        <property type="nucleotide sequence ID" value="XM_013084131.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826389.1">
        <property type="nucleotide sequence ID" value="XM_035970496.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851742"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15134">
        <property type="entry name" value="7tmA_capaR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005390">
        <property type="entry name" value="NeuromedU_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01565">
        <property type="entry name" value="NEUROMEDINUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="60"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="487"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005101265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012939584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012939585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035826389.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="63445" checksum="5E802BB09265A3D7" modified="2025-10-08" version="1">MELIEVDSWYSNETVAQFKNNTTDVTQLLLEKLGPRRRDLASVILLTIVYSIIFLSGVVGNVCTCLVIAKTHSMQTTTNYYLFSLAVSDLLLILIGLPPELYSIWEAYPWRLGEAFCYLRQSVLESTSYASVLTITAFTVERYLAICHPLLAHKISALSRAVKIIISIWAVSLMVALPYAAHTRIYYQVRVPETNEAVPESLMCSIPYHFLSGFMYYMFQVSTFIFFITPVTVIIILYILIGVSLRRSPLARGASDERSYSSMKSSSKLPQQPRKVVIRMLIAVTVAFIVCWAPFHAQRLMTLYVPHWTPHLLEVQSHIFYISGVLYFVSSTVNPILYNVISKRYRAAFKQIIFPCCYTKPVPGTNCVPRHSERSKSQAMVVLRNGHDSLRVMFRQDSNDTATNYETIPLNGSLRHHTLQSNDLVIPEHSSMGNSSSSGGSADVIVSQSYTGIVAGQVQTSIAVPPSKRFSFTGKDRELKQDDYVITNRGAEAREKGTGEREGDGEKGEDRGDGNPCIVSRDDKTAAALRKAEKPRKSYAHQVNGRVSFKQAPPSCDCDAVHTTTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTT4</accession>
    <name>A0ABM0JTT4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gamma-gliadin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101320.1">
        <property type="nucleotide sequence ID" value="XM_005101263.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845009"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101320.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31760" checksum="F19A516A8F3AACD1" modified="2025-10-08" version="1">MTVVRVRAIYVVGSVLPSALAVIFAVIISSRKADTTSEYYDSPQSDGILLSQEVTPHIDEGYPHQSNELEPPQHQYYPEHPQHQYYPEHPQHQYYPEHPQQQYYPEPPQQQYYPEHPQQQYYPGPPQQQYYPEPPQQQYYPEPPQQQYYPEHPQEPDQQGTPQQQYYPEHPQQQYYYRASQPSAYVRLPQDPGPRQPAYPPQQMATTQVVIQTSVSWTQPPSDQQVIHPGMNGQTLHIGYSGSTSVLFAFDFAHETQTFKVFMTTQVSQKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUP7</accession>
    <name>A0ABM0JUP7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101847826 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C65 family. Otulin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101937.1">
        <property type="nucleotide sequence ID" value="XM_005101880.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847826"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22790">
        <property type="entry name" value="OTU_OTUL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023235">
        <property type="entry name" value="FAM105"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33662:SF3">
        <property type="entry name" value="FIBROUS SHEATH CABYR-BINDING PROTEIN-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33662">
        <property type="entry name" value="OTU DEUBIQUITINASE WITH LINEAR LINKAGE-SPECIFICITY A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16218">
        <property type="entry name" value="Peptidase_C101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02055">
        <property type="entry name" value="PROTEINF105"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="714"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101937.1"/>
        </source>
    </evidence>
    <sequence length="1113" mass="121675" checksum="AA68CDA796B67DA3" modified="2025-10-08" version="1">MEAGYATTAPTIDPLASPPPPPLPHPRPSLSTTPPTPSSLLLSSPSSVLPRAAFTTSSPTSLSSSAASNNVPTNTPSSSFPSSFPSSSTLTPSPTAIMPPSSSTCSVPTADTLSSSSPLSSSSPSSSLPCPPQWQVSIRTPRVSDTLTSSHPESRALLPCVSWDVILSIYRELVTLINRLPFKQKLVVCLVFRGSKVRLDLGEVRAAGVACLIGLGLSLGTLLLYRLYFRIVVPFLSSVWRDRGQGLLDDEYTLYLEPSDSEVDDKMGNSHSKKSTPSVYYAPGYGVTLGSRPPSLDLDNDVDLREEGIRLRPHLARPRYKSPSPASDRDSAIGGVTGSEMSQSQYSEVSANRDSFYSSCTAESGFDDLMACFEDVRAQRKWSNSAKENFPPGSLRERNLNLLYRAHHGYDPGLNNLGRSVKPGLDTLSDVSSERSGIVSSRSQHSSCAGDSQRSGRVTRTNVDPLEDRFALQRHPSSDAGTTSGQSLSGRQDMGVCGGSAFTGDGVVGMSEPASTPHLLSAQSSPYGRRVHPCSRGRGHSPATGQQHFSPIRRPDGSCLDQQLDYDPSLDASESIRSFNSSGDGIDWDVELEDSGERMSTLPEFQQSLSDVQFQQSLMQRIHEWSTFAEEYNKSRSPTPHCSPIRFVRRSRSLDRHLGDSSAVLVSDHDIAGSKPTEMEPTTEKNLECLEYELQDIQGEFESITSKLHELIEQGNAKKASPKSSQAPATHTQSDAHCAASGSPAAPHSTPRPSHTWPRPQHSAGRPTINSTPHIRKMRTRWERVPSSGCSDSSRSSRASSVEYAWDLADYANNSTVSTTGDQSHLEPQVEAQSSWQHGPEVTNIGLPVVISDYSEGEWKGSTDRAKVIREGYSKIPSLLSCHRMSVVRGDNYCGLRSTLFQVLVSGHRVTNHWTGIIPVMDSLHDMYQSDSNCLAHWTFANRLPGHCADRLSSLSKCALSLYATIEEVCNLSSWEEREKRTLGLFNSSSTFDLELMEGLKLMMFLKLVEMKKLLDIGEDVPVFGHLLFARDSSETVEAFLKNHLNRVGDTGGLEQVEMCLLGYCLGVRIRVLRLSQCGQQDFDCVFPEDVPSDWPEVQLIAEDDRHYNVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVJ1</accession>
    <name>A0ABM0JVJ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TWiK family of potassium channels protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005102539.3">
        <property type="nucleotide sequence ID" value="XM_005102482.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845630"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="65"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005102539.3"/>
        </source>
    </evidence>
    <sequence length="165" mass="18457" checksum="8E295D7295428977" modified="2025-10-08" version="1">MATGFRLLYGKVCCGLCCTLFKPRRRRVAMDVEKGLGRPLVTTEEEQPDKPKEVIHVPTSLCLLLIAAYIFAGAMLFSIWEEWDMLMGSYFCFITLSTIGFGDIVPGMEGSAWAHEEKLVLCALYLVLGLSLIAMCFNLVQEDVKAKCRWLGMKLGIVEKPETPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVY6</accession>
    <name>A0ABM0JVY6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-like protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102783.1">
        <property type="nucleotide sequence ID" value="XM_005102726.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860182"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="61"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005102783.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="69951" checksum="4DC8CDCAE9772FA2" modified="2025-10-08" version="1">MPDELTSAVLRKKLKVTQVMAEGGDMAGSSSTDVFRMEERPEHGMKVLQGLNKLKQDGILCDVTLIAEGTRFNCHRVILVSCSDYFLSMFTSGMRECNQKEIELKGITAKGLEKVIEVVYTSTTTLEGDDIFDVIAAATHLQVTPVIEFCERNFLSGMNTSNFYDFINTAKLYSMHNALKQIDVFIARNLMQIAKENTLNLLTFEQMVSCLNSDKLCFREMDIFHITWEWLRMDAKRLCNAPVLMKLIRFPLINPADLVHQVQRVELMMSSPELRQMVLTALNYHVVPHSQPLLNTSSTRLRSFVERLVSVGGREIHPNPCLHDELLVFDSRITSSSLLNRQEIATLPSALSHMQVLVYNNFLYVLGGCTTQCAHGESAVNSVLRYDSRFDTWFQVCPMLNKRAYFFAGALNNRIYSVGGKFKDGSLATAECYDPAENTWELISSMPMSYHAHAGATYGSHIFISGGYSGNHFTPDMQRYDPTSNQWEDMAPMLTPRGWHVMCASHDKLFVFGGCNLNVNQQAQPVMQSECYDPATDQWTIVAPLSISHKEASCVVYRDHIYVLGGYNVQTKTGQKLVSKYDVYTGIWETVGALPRSLTGVGYCTIRLPSYDPDELQAETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXJ5</accession>
    <name>A0ABM0JXJ5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-gulonolactone oxidase</fullName>
            <shortName evidence="8">LGO</shortName>
            <ecNumber evidence="8">1.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101864542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-gulono-1,4-lactone + O2 = L-ascorbate + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32363"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17587"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="EC" id="1.1.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Microsome membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.8" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005103891.1">
        <property type="nucleotide sequence ID" value="XM_005103834.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864542"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01679">
        <property type="entry name" value="bact_FAD_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF8">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005103891.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="52337" checksum="C09A588D594149E7" modified="2025-10-08" version="1">MSNFDIRTLGKSGRQFTNWATTYSCQPELYFEPENNEEIKNIVDYAREKGKKVKVVGFGHSPSDIACTTDFMISLKRYNKVLKVDEEKSQVSVQAGCLIKDLNHNVLPAHNLAFSVQGTVDDLSAAGVISTGTHGTGTNFGIVSSYVVDLTLMKASGEIITISKEENSELFNAAVLGLGSLGVILSVTFQCEKAYRLHQRQFPSSLKNVIDNFDKHVAEADHFRFMWYPHTESVVCYSASRTKKEPAVKSSWFWDMFVGYHLLQLLLWISTFVPCLVKSINRLYFRLMCQQPIEKVARSDRVFNFNCLFKQYVTEWAIPKENTGVVLYKLKDWIEQNGFYAHFPVEVRFVRADDIYLSPCYQQDSCYINIIMYRPFNKLVDHESYWTAYESIMAEHGGRPHWAKAHKYTGLQFQKIYPKWKEFCAIREKLDPNGMFLNANLERVFDARPSPSTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXP7</accession>
    <name>A0ABM0JXP7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864638</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103976.1">
        <property type="nucleotide sequence ID" value="XM_005103919.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864638"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF2">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="1">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103976.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="34007" checksum="C9B4D1CEEE9B7189" modified="2025-10-08" version="1">MLIPPVRNLILYPWWPRIWREVSTIDIIVMTRREFPPNVTALQCVKRVPPIVERDDKRLFGDMRFLKKPAFPVTSMESAKSLKLNHPDHKLFLPAMSKEESKDLLHTYLVIAEALQKVNVEHFLEGGSMLGSLRHQGFIPWDDDLDIAINVKDWVKVREALSCIEGFHLRVQPNMHWAFRRQRYRFPYIDIFFYAEDETHIWALAYYIMRMTFVLSKKDVFPLTTGFFEGHLVPLPRYADRVARKVFEYDYCLSPDAHHRDHVELPVRKNVPCSELSYLYQSFNLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXY6</accession>
    <name>A0ABM0JXY6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Keratinocyte-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101849142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRTCAP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104174.1">
        <property type="nucleotide sequence ID" value="XM_005104117.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849142"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018614">
        <property type="entry name" value="KRTCAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001:SF1">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09775">
        <property type="entry name" value="Keratin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005104174.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14292" checksum="2EF20AD354C4081F" modified="2025-10-08" version="1">MALPTGASAAVSLLLTITLFALMQIFKEIISSTEYFTIAGGFMGSLLFITLLTFVSNMEVFLFGKGFQTRLFPEVIACLFLAMFSSALVHRVCVTTCFIFSAVALYYINRISQSMYAPPVAAASVSSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY04</accession>
    <name>A0ABM0JY04_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G patch domain-containing protein 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104205.1">
        <property type="nucleotide sequence ID" value="XM_005104148.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856200"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040341">
        <property type="entry name" value="GPATCH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390:SF2">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="537"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104205.1"/>
        </source>
    </evidence>
    <sequence length="646" mass="72759" checksum="0C13341B1B4EA977" modified="2025-10-08" version="1">MAMATQETETSSYVAITNIPFKFHTADLRSFFSSYVESNGFICFHFRHRPEKTESSLENENEKTTTSRSCATTDEAGERVKRCCCVAKVKNSRLPSFLKAYHNQNWTDSNDEYHGDLCHISVINTRSNDSSGTDTSGHVDEKTLESMPELRPVELMPQGNVGTPTLVFLDLIQRCLLPHSLIHKLKLKFPKTSGKLLYSNVPFEYHTPKDSDFAANTPNLESGAGVVKSFPSLTQERNVKTKCLRKSDAFGKIQAFELSESSTLLSDDCNEQTPNVINDSSIAIETSSDQSTFQDAQMDMIPHPYKAEESQNTDMDGLNTEDKSVQIEASVSNANNQSGFLAPQVPLTNRERKRKKRYENRSTRKLMAEGIEERLIAIDKIYRNDDDAEEWDRHEASEDDPSNQERNKERLYEEEIEQPWEKGGPGVVFYTDAMFWQEREGDFDEQTTDDLDVDFSAYEEQGAGDKDIKDFLKIRQETRFRNGYDSTDRFSIGIGKKIDKPSSSISSAGNEVSASQHGRGSKLVSSGAAIGAFERHTKGIGRKVMEKQGWREGQGLGSSKPGITEALRGEGQRPHDKQGLGFVAEKPVWYGVPPAKKSRGKSKQSHLITTVYDDPREADPKEPLLLRSEPTTLKHRQTHKDSFNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ05</accession>
    <name>A0ABM0JZ05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101849392</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104864.1">
        <property type="nucleotide sequence ID" value="XM_005104807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849392"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045899921" evidence="2">
        <location>
            <begin position="30"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104864.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18375" checksum="37787DA59EB6265E" modified="2025-10-08" version="1">MKGFSDMTLKSFTYIFLLLLCVVIHTGMCEEGCGQGCQSLGNDNHELSRCVRYACRRRVFRYYIRFGKRGGGGGVGDGGSVGGMGSSDLEPQSLSDQRLSNLPRHEQLQHQRYLVQRRRLQQQREEPPSIFRTPEAEGVYPSLTSSRMSRLYPLVRLLLGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ81</accession>
    <name>A0ABM0JZ81_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101864167</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105013.1">
        <property type="nucleotide sequence ID" value="XM_005104956.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864167"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047319771" evidence="2">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105013.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13752" checksum="292DF6ACC660CA19" modified="2025-10-08" version="1">MSLLKNLLLLLVVLVCAGADDCEYRKPTDFYPSFKSCDNGCCGPYVTSDPCCEDDPFYTGTPFIAGTATGSVLLVLGACLSAWAKTSKENDKNKSTTTTATQQRVVSTTTTVNMPAQNAFGYPAVKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K069</accession>
    <name>A0ABM0K069_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101854518</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005105668.2">
        <property type="nucleotide sequence ID" value="XM_005105611.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854518"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000830">
        <property type="entry name" value="Peripherin/rom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00218">
        <property type="entry name" value="PERIPHERNRDS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="734"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="803"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="877"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="812"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005105668.2"/>
        </source>
    </evidence>
    <sequence length="979" mass="108392" checksum="B5EF32AA78965A56" modified="2025-10-08" version="1">MDTVQTDYRCCGDRSYTDWFVRAWLDPGHLSVVVPGEKKKFLQEDGRYHSDDTPYSCCDPRAPRPCVHHHVHSSKLHKSYQPLEETTLYVQGCRQALARVYGNVLLTVALIALLIATVKTSVLLLVRLVQTSLTHARTDGEWAAASDAYIYYVTPQDDDDTADSDAGGDNSASAGEGTATDGEVTTSAEQEEEGESGESEESGSSHVGDSSSNKIMPGTSSSLRVSKRQGRHTDTERGTVEEADTDTGSDDSSSSRSKGRSGRKKSIARRKSRGYLLSESVLSTRHDSNHNHNVSAKNNNAYPRLLYPPDSSPNLGSKNSPIYKSGGGGFLRGAVSVLRTATDALNVRGFKRQRYKGSLGASYKYRPLQAGGESDGDDAHDVCFVPDVRSDEERVNKESNLQGLNGRQTTLRQVNAGTTTFSSRNIDFADEAASQRYKTHSAEIRNLDSTPKNISKDNTCRISLDQGHNFVNDLIEIQENTPSFCSRQERPKIARTNLTVSADSPHWRGYTWTQESPATSCPVPVLPETPGEEHTYSPVYLTKDEKSLLHSFNKRKQHSAEKSSDISKISRMGPPTFLSLTSQCTGSYGQTLSPFSSPKCPTGFRRPPQNERNSSLRQAPTGTANESDVSSEYSEPELEGHCFSTLNKPSTFNSDFSGPVQYKEHSRYQHRKEANTTTDSSEAVSLEVIHKKPPWSVNRRLESQSLYRQDSALWKQEPTINTNANNVRSLTELRKGSHRHTLDSEVKENNDSLTPHRQTQRTKPHLPRALTYPETASNIPEMRAIERDNSLSLQTSPYKNVTVDGKQGRSSQHCDLESKEHETFQRSGVDNKRRGGNEVVSDISPLRDPLNVTTFLVASEAMRSRSVPLTQQCLGRQSDTAKSVFGGPACRNSPHVLRRSPATYSRSLDSNPGEERSPKSRLLSRRGEDSGSGRDTSSYIPSCYRREQRASQGSSPKHPRASPLLEPTCSETKSYFAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K074</accession>
    <name>A0ABM0K074_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TBC1 domain family member 5 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105675.1">
        <property type="nucleotide sequence ID" value="XM_005105618.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856285"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="107"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="881"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="920"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105675.1"/>
        </source>
    </evidence>
    <sequence length="983" mass="110877" checksum="B4F03DA2F7247CD9" modified="2025-10-08" version="1">METLAKLKPRSNRKNPQLDSATSKDDILNAMENYGASDGAGSNKENNNNSEQMSRGSSLDGKWEMVDPDYGSPAASLSHSYSLEWEKLFTQAEMMRKLKVRASEGKLRSSRFRSVVWKLFLEVLPADMGQWVEKTRVSRAKFEELKNKLIVNPRKAVDSVNLSLHNPLSQDEESPWNKFFQDNELRLTIKQDVIRTFPEVEFFRSTDMGAMMIDILFCYSREHATSSYKQGMHELLAPLIFVLHCDHQAFLHACEIESVLEVMKEVMDPAYLEHDAYSMFCQVMETVEPWYLSRDYSFAKGGSLRSLEIINATPFSRSQDLNPSNAIVTKLTRIQDYILKKYDQELHQHLERLEIAPQIYGIRWLRLLFGREFPMQDLLMLWDAIFADGIGFDLVDYVFVAMLLYLRDILLSCDYATCLTALMKYPPVPDVHYFVDKALWLREPNQNPRPPNYTHVGGIRTSSSMGSGDNMSSGASSSCRDNARDHSTDPIGSTVSLSQVEESMFRHAPSASSMAKLETSNLRSAQSSPGIHHSNVFPLTPEDPSVTGSPTKSQTLLGRAKPKQKKMTKVERELQEQVTHLQGELNDKATMCRYCASKLDVHIGRLQQDLSKQNLDVDDEVMVSLAGLKLVRDVLNGTLKFSQTIADDEEININEDFYSSQDDEVSAYGSEQRRDDNSTGVTSPESDIQLETENRRVPARQRALLRNRSSEDTSTDSGTPGDVHGPDMPPHGAAEREVKGNSAVELWDYHVNADSLDKMVNADSLDKMGAGALKSAEGSSSFGGDEALDGGAVNTNTNATSSNPFTSKIRSMFKSVDPKEQQQMQQRQKLLLQQQLQQQQQQQTQAYEVLPGSRKSSDYPSSTRVESDDFDRVPGRHRRSSREEQAEKELGSMDSRRRAKSNVDMPSRTYWPDFATSSGQERRPVEQLEGRGDRRGSGQGDRRLREGRERSKSQPSKSLFGAEGQGEGINPLYKLKYDQGMEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0U5</accession>
    <name>A0ABM0K0U5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 229B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101858053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM229 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106105.3">
        <property type="nucleotide sequence ID" value="XM_005106048.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858053"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31746">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 229 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31746:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 229B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005106105.3"/>
        </source>
    </evidence>
    <sequence length="250" mass="28733" checksum="28E82D0CAD9AE31F" modified="2025-10-08" version="1">MYVMYCADFGRSTERNQLIGNFAKGVVYEVATDWFVLIDLTSAPLVGFRLCSDSFPLNRGVARAHRFNQVTMAVFTLERISTLGRFYIYAIHGYATEVMFTALWEFVVNMNWKFPGNTSIWSFPIYGLSGLVFEYLYLCMSSRGIPLPLRALVYTLWTYCWEFGTGFILKQFGACPWDYTPFHGDFMGIVTLEYAPLWYLGAIVNEKLVMYYSRRIFFGPPMEEMKETSVKQDSKLIINGAAGDVEKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0X2</accession>
    <name>A0ABM0K0X2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cullin-3-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106158.1">
        <property type="nucleotide sequence ID" value="XM_005106101.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850358"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="384"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005106158.1"/>
        </source>
    </evidence>
    <sequence length="763" mass="88236" checksum="B8A999D57E82D8EA" modified="2025-10-08" version="1">MSSMGSRPQSRKDTKMRIRAFPMTMDEKYVNNIWSLLKNAIQEIQKKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLRDVVTEHLIGKVREDVLRALNNNFLQTLNAAWNDHQTSMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRHPSIRDHLRSTLLEMVSKERKGEVVDRGAVKNACQMLMILGIDSRVVYEEDFERPFLDQSAEFYRLESQKFLAENSASVYIKKVEARINEEAERATHYLDKSTEEPVVKVLEEELISKHMKTIVEMENSGVVHMLENNKTDDLACMYKLFIRVGDGLKTMSDCISKYLREQGRALVSEEGEESKNAITYVQNLLDLKDRFGHFLHESFSDDKIFKQMISSDFEYFINLNPKSPEYLSLFVDDKLKKGVKGMTEQEIENVLDKSMVLFRYLQEKDVFERYYKQHLARRLLLNKSGSDDSEKNMISKLKTECGCQFTSKLEGMFKDMALSSSIQEEFKHYCAEKKVVLFGVDLTVRVLTTGYWPTQTATPINIPAEPRAAFEGFRVFYLSKHSGRQLTLQPHLGSADLHASFSGAKREDADSGPASSAKGIRKHILQVSTYQMCVLVLFNIRDKWTFEEIKNETDMPERELTRALQSLAVGKIGQRILQKEPKTKDIEASHIFSVNDQFSSKLVRVKIQMVASNKGEAEPESRATRIKVDEDRKHEIEAALVRIMKARKKLQHNSLVAECTEMLRPRFLPSPVVIKKRIEGLIEREYLARATEDRKIYTYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K271</accession>
    <name>A0ABM0K271_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106996.1">
        <property type="nucleotide sequence ID" value="XM_005106939.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862529"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF7">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005106996.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="45990" checksum="26C633E55184F1C9" modified="2025-10-08" version="1">MAFRNWLGLFLMGAINNLPYVVVNSAASTIADSFNEKNLVGVVFGANVALSVLVKGLNTFVLLNVSYALRYIVNGCVMLVGLFGIAYAFNFGFAIACIAVLGSSAAFGENVTLGFLSWFPSSLVSAWSSGTGMAGVLGSTLFIIFGCAVGHGDSETKELKNLDKYAFLLTTPVVLVYWLAYFVIIKRPAINDDVDREISPGPEGSSQEVVTHEPTDDDIVVARNAEIMNNIQEDDPLLDTDEIVIQKHERTCARILRCTRLILWMGTNLCAVYVFEYVARGCAAKARPKSEYHVGCPELYAALQLCYQAGVFVSRSSVQLVRIRRVEILSLLQLINMILWLVDVHYKFLPVAVLPALMVYVGLLGGASYVNIFYSLLHDDVYPKEDRELCVNLTGLFITLGIVLGTGLETAIFTTLLKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2I2</accession>
    <name>A0ABM0K2I2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101861609</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107241.2">
        <property type="nucleotide sequence ID" value="XM_005107184.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861609"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23826">
        <property type="entry name" value="UEV_Morgue-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="251"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005107241.2"/>
        </source>
    </evidence>
    <sequence length="411" mass="47506" checksum="3CAD474B5C6CE9AD" modified="2025-10-08" version="1">MLLKKLHWDTTKMENVNKNTGDDMTEQVPDNISKKTLEQFLKSEQYESCMMCSGFYGKSFGQPVCSTCHLFLFSIDLKEDGEEGDNRAYEKVDSDDSGTEEPGAETDFYASNDIGEREVQHQARRPARLKADRLTERINALTIPREQDVVPVGLIESLPPEVLLLVFKNLDDISLWVASNVCTRWRQILDGEISQSQWKHFLQLRWPLFQPQFKVRCWKTIYSQLLLSSPCRYCLESMMLQSTPPIEENSWRHRRLRSELKTLRTDPPEGIQATPLDRYCCHWQASITGPQGSPYEGGLFLLYLQIPQNYPMRPPKVRFITKIFHPNISRHGDVGLDSIHHNWSLALTISKVLISIQSLLTDPFCTVCMEPTVGKLFKSDRFQFDRMARLCTWKYAMHDYVMALNIDPDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K300</accession>
    <name>A0ABM0K300_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Espin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107566.2">
        <property type="nucleotide sequence ID" value="XM_005107509.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859359"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107566.2"/>
        </source>
    </evidence>
    <sequence length="174" mass="19521" checksum="62D318A9E67A4A08" modified="2025-10-08" version="1">MDFEIPDDIDLSQCPGLVEITKATPNWKKEMIEKKNQDKIEEYVKKILKQREQEAKWKNVPEWKRKLLQKKDEEDAAAGVTPVASPAPSGKKPAAPAAQPASYDDFVQPKAKGDIVPAALSIDPEELAAMPPWKRELLFKRDKVPVTFSNEFNPDEEENEVPQGVPEMADPNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K301</accession>
    <name>A0ABM0K301_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sarcoplasmic calcium-binding proteins I, III, and IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107567.2">
        <property type="nucleotide sequence ID" value="XM_005107510.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859596"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107567.2"/>
        </source>
    </evidence>
    <sequence length="240" mass="27932" checksum="53FFE6F862A7A93D" modified="2025-10-08" version="1">MPLEVELSPFQKEKLQSYFKFLEPDANGKLESHSLDRILKRIFEFTRWQKDSAKALQCKEIHTAFFEILFEKAVEEGGKRGMASLDDWYHIWAHILPGCKGMSNFPVWLRLMPKMLFDMIDRNGDGLITEEELIRFYREMVKVEDPALEGHTKEAYKDMTDGGRYPLNLDGYEQIFANFLIGKTPHGPGKYIFGCFKHDNTNWQLIAPLSTHDDAHSAKPKEENKIVQEKRPKKFGVLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3V6</accession>
    <name>A0ABM0K3V6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855371</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108142.1">
        <property type="nucleotide sequence ID" value="XM_005108085.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855371"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005108142.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20404" checksum="67A16BED5E24129A" modified="2025-10-08" version="1">MDIIKRVDKHRIVAVLRELPCLWDERSEDFKNTKLKDNARQKILLVLSIPDARDTAVALSRQISHWKSYYRKELTEVEKNPGYKPRWSLYNDLDQFLRPVFLERVRASLQVRADRMKEASPSPAGLAQEQAACDEWTTLGNHVAATLKSFDRKRATNAADEISDVLNKYSRYWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4M6</accession>
    <name>A0ABM0K4M6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101856052</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108659.2">
        <property type="nucleotide sequence ID" value="XM_005108602.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856052"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045546408" evidence="2">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108659.2"/>
        </source>
    </evidence>
    <sequence length="208" mass="22064" checksum="D7D613E66E8E57F0" modified="2025-10-08" version="1">MVVRVAFAALVAACLLCAIGCGSPFWTKGQLTINSTSAGLPGINGTTNNLRTVKYSGGLFWYCIVDFPDEERECHTFPYDQGTGEELGLFGLAIAQMVFSIVSVLVAFCCVKCCKGKDGGGCYCCFGLLCFLAGLFGLAVVIMVAESTGRTWGMDVKQKSNDWGMFVYAAGATLTCLVSFVLCCSDPDAGTTVVVRRVTAFARGVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4Q2</accession>
    <name>A0ABM0K4Q2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit theta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108701.1">
        <property type="nucleotide sequence ID" value="XM_005108644.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845428"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108701.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="59298" checksum="1A5EB5C22CD4BD2E" modified="2025-10-08" version="1">MALHVPRAPGFAQMMKEGAKHYSGLEEAVYRNIDACKELAQTTVSAYGPHGQNKMVINHLEKLFVTNDAATILRELEVEHPAAKILVMASQQQEQECGDGTNFVLGFAGALLENAEELLRMGLSVAEVTEGYELACKKVLDILPELSIGTVKDMRNLKEVLPAIRTSVMSKQYGNEDFLAELIAKACISILPGKVSFNVDNIRVCKIPGSGILQSEVIQGMMFKRQVEGDVTKAENAKVVVYSCPLDAMQTETKGTVLIKNADELLNFSKGEENQMEEQIKAIADAGVNVIVTGGKVGDLALHYANKYKLMLVRLLSKWDLRRLCKSIGATPLPKITAPTTDECGYCDRAYVDEIGDTPVVVFKQDKKESPIATVVIRGSTDNIMDDIERAIDDGVNTFKALTKDNRIVPGAGATEIELATQVATFGESLPGLEQYSVKKYSESLEMVPKALARNAGVKETEVLGKLYAAHHEKKVNIGVDIEAEGAAVVDAAEANIIDLFITKYWGLKFATSAACTVLRVDQIIMAKRAGGPKAKQNKDWDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5V4</accession>
    <name>A0ABM0K5V4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101859517</name>
        <name evidence="9" type="synonym">inx</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109439.2">
        <property type="nucleotide sequence ID" value="XM_005109382.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859517"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005109439.2"/>
        </source>
    </evidence>
    <sequence length="458" mass="52455" checksum="8C156BB303ED6897" modified="2025-10-08" version="1">MSFSKVLTASAVVRVSDEDLCSQLNHVWTVSLLATLGFLITLVQYVGDPIQCWCPAQMPDAHCNYTKALCWVKENYYVNKDEYIQFKEEDRAENQIAYYPWVPWILFSMAFALKLPHVMWTSFLPSSGLNLGKLVDLADSHENIDNLAKIIRIWLVRTHRVQKNVLSRVKKILGSVGLFWMGKNSRTYLTGLTIGVKWAYLLVTIGLFFSLNLFIQEEFISYGFEVLDGFLRGIPRESVTFPKNTICDFKIRQLANIHTYSIQCVLPINMYNEYIFIFLWFWLVLLCVVNTYSLIKWNFYLLSPGQRREFVKGYAAIVFRLLQEAQKPPDVDTNGNSLSSAPANDATPILNGASPSGDNNGVPRERRRLRFDSIVSVTSSGGTDVRAAPPSQIEEDPKEARRRQDERQIDRITNRMIKHFGHDGVVVFRTLESGVGVIIANQIFQELYLQITHAMHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6A6</accession>
    <name>A0ABM0K6A6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101847069</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101847069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109729.1">
        <property type="nucleotide sequence ID" value="XM_005109672.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847069"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14651">
        <property type="entry name" value="Lipocalin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005109729.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15770" checksum="C6A6E16333623E84" modified="2025-10-08" version="1">MEAFIGTWRHDVSKNENLDAFLKVLEVPDALLPALKKRQYTYKISKSGDNWTFEMSDENDPSLSPKTYTVKENQDYEVVDLDGVKYKVTMNMDGNKSTEKMTMHETGLVVNVSRVVEGNTMKAVHSCKGASMTAYFVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K760</accession>
    <name>A0ABM0K760_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Scavenger receptor cysteine-rich domain superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110340.2">
        <property type="nucleotide sequence ID" value="XM_005110283.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15494">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="5">
        <location>
            <begin position="233"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="378"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="622"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="739"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="853"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="1089"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="1304"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110340.2"/>
        </source>
    </evidence>
    <sequence length="1406" mass="154869" checksum="8429A6D612AA5027" modified="2025-10-08" version="1">MESSPRIDQQIPYDNSGELNSIPVQENEAADVVAAMENSPRVDLQNPYENSSELNNTGVYENEAFDNATASEISPRVDLQVQYDNSSELNNIGVHENEAFEADAATGSSPAVDEQTIQIQCEDSSTGNLYNTPDEQETADVVAATESSAPVDSPQTFQIQCDDTNGKKYYSTDEVIPGKSQKVTSTRWLVIAAVAGGAILVVILAIGLSLGLKDSEESPQPVQSSRLQEHPNAEPDFTVSLIVENMTWAAPMSDVNSDVFTSTAHDIEQSVDKYYESSPLADIYNFSMVTQLWPGSVGCNVGIFLKPPSNTSTVELRDMHAQIKAGNGTEVLSRNFLKGAADFWSAQAQLPEDQRLSALNFKTDFFEKVLVNDTEPLNNTVNTTKHMDGEIMLNERDEALMFLTAKWTPVCFSFSWHLWLAQVVCAQLGYSFGNSVSGEYLSSTVVDKISDIHCDNTATALVNCSYITSTRPCPAARILCTNIESSYKLVNITEEGNEDFMEVTRDGVQALLCGPSYPWAAAELSNLYCQEVGFQHGGQSLPVLESDVEDVDKVWRVLLSCGQVATRVNDCVASTWSLDNVTEASPEDSMKKTRRLPSFRGNLTKDEVRVCLVKVACFKPQVTFHGGLANTSGIVMIPNPNTLWERSAVCADGFTDKEAGLVCDTLGFGATGQAYSFNPYPFTEQYLDSSDMAMRCSNDALNASDCLVPLTGRCRSFAVANCNSDEKKVPELSTKLFWDGRTVLIYKNNMWGSICPTMEEPLLGEREATIICNDLGYERGIAQGGHPSYFTTVPYNQLSVFSYIPHVIREVKCGDTAQTLRDCEWKNVSANDGCQNARPAALFCHNASDLAQYEMSGGTEPFFGTVKVTFNGQQGYLAFDHPRLSPVPQIVCRSLGFANGQAADPSEVTLANVKKIWKISVMEDGCSELDIVETCLDKHWSQYQLQEYDEEKDESKLVKVFCNGAVSLGSGYHNRSGPVQINTDYGPWVMARGDITQLVGDIACREIFGSHTFKSLIVPEVVYKKYARCSEVTCTQSDTSLADCVDIRQGEGHCGDSGGILCYEGSPPAAPSSSNQWRFSDKQFLWQNIEVKVLGEWSVVCADNWTDTEAMAFCKYLDPKNTQGFALKKDRKFEKGMWVKSVDCGGQGVESIQDCSLTIYTSDDEKCSSDQEAYAACFKENEVPELGMDVKTSSLQYDAGYITVTRLDKEGYFCPKFHYSDYEANKLCSILPGNFTGGVVLDKALLSRPDQFSSLWAGSLLCPHEPLQIRTCEQDWMNQNMTDHSVSPSPSSCIEPVACFKLNVRLHTPLQNSGVLLVYDGQRWVSVCTDNFIPSYGGKLCQQMGFGCGRMSPGTTLGYSFFTAQFICSRTPDGGCTFVRRNPPYPKCKEHILLNCSNECDNESTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7R3</accession>
    <name>A0ABM0K7R3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101857287 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110768.1">
        <property type="nucleotide sequence ID" value="XM_005110711.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857287"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="5">
        <location>
            <begin position="655"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005110768.1"/>
        </source>
    </evidence>
    <sequence length="805" mass="89317" checksum="A5F834F7774B9794" modified="2025-10-08" version="1">MATGGVDLVEVEDWRTTNQDFHYDKWRKCNVCDHGYKAPVALPCLHTACYNCLLRHIHVQRIQVTNQVNEAQGRYIFLNFPEVFTCPQCSFPLYVKRKMDKLKINTRLLRLTFQQRYRWHTCNNKDFIIEYSGEAKMYDLIYQEPLDLSTASPPSSSDEFEGRADNDQSQGASSQSEGNGERNNEGNRGQDGGIDTRGRLPEEQEQYDDRAIEGSSDPTFVTRGKETSEGQGLERVEEGGSSGGRSNEGSGGSEADRESVSGRSAGSKGRGCAVGSGSDTVGSSGGSGDDFVRVGRGDNVATSGSEGDKGTGEEKSYGLSASDGNVNRGNEEEELQGAVGGVEEKSLSQRVMELHGVRQGPNPLSPETDDSPGSDSEVWGKPKKPSSRESPDSDPTDPEEKYVTSDDPTVRKTLKDRKSRRLKTACIFREHLAHVTRHVPYDRVEALTNDDSYPPGIQAAQLLHQYDLGFGHGELEVIHPIAIGLNPRTGHLVVADSTLSKAVMFSKPNCPVGAKRIDNPVSVCCFMKQSDHYREERFCFGGHSRTSHEIKLFCVPFKSPSQMTVISQPMRDISGLLMRGPLNRLVMCLPHTNDVFAETNDGRHRIIASGKSQGLFNPTHIIEGHDEFELLLADTNNHRIVKLFGPDFMAYSTYGRFGSLPGQFFYPLGLALDSKKRLFVCDANNYRVQVLDKDFEFESAPIIHTFNLGRSVTQDVKPVDCAVDSRDRLTVLFTGREFAAIQVYRYLQPLHVITQGDNLIVVEPSCCEENCTSCYLCCRRCCCCCDSDDEVSGGARRREDYERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K975</accession>
    <name>A0ABM0K975_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Legumain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111879.1">
        <property type="nucleotide sequence ID" value="XM_005111822.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850219"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Legumain prodomain" evidence="2">
        <location>
            <begin position="300"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111879.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46282" checksum="F82D1EE80A424FA8" modified="2025-10-08" version="1">MRNNSIPPENIVHMSNDDVAHDPENPIQGNLVNVPEGPNLYPGCEMDYRKEEVTPEVFLKVLAGDKEGVKELIGRDGKVIASGPDDHVFVYMIDHGSPGVFYFPDLTGLHNTDLINVLNQMYREKSYKEMVIYMQSCYSGSMFEGLLPNNINIYVTTSANAHEGAYMCCWDQFRKVYVGSVYDNAWMYNTDKTNLHKETLYQQYEVVKKACSTARGVSHPQQYGYLSMNKEVLAQYQAKSEQYTPGVCRNTQDTDEHTQGSKFTYAGIDLNNPALDMVQIATTARRLIESRDLSGQKRKKLEAELRHLMLVKKKAESLTKDLVRAALSSLRGVTETDILTGKERVDNSECYKAALSLFSARCPGIDMGRYPFARRNLQAFINLCNHQPQIDVMNAIMEVTEKYGICRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9N3</accession>
    <name>A0ABM0K9N3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Meiosis regulator and mRNA stability factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101856947</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112252.1">
        <property type="nucleotide sequence ID" value="XM_005112195.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005112253.1">
        <property type="nucleotide sequence ID" value="XM_005112196.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856947"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08824">
        <property type="entry name" value="LOTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10910">
        <property type="entry name" value="PIN_limkain_b1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024768">
        <property type="entry name" value="Marf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045602">
        <property type="entry name" value="MARF1_LOTUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034189">
        <property type="entry name" value="MARF1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379">
        <property type="entry name" value="LIMKAIN B LKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379:SF3">
        <property type="entry name" value="MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19687">
        <property type="entry name" value="MARF1_LOTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11608">
        <property type="entry name" value="RRM_MARF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH OST-type" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="4">
        <location>
            <begin position="1138"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="4">
        <location>
            <begin position="1222"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="4">
        <location>
            <begin position="1438"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1517"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1688"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1530"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1542"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1561"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1726"/>
            <end position="1743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005112252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005112253.1"/>
        </source>
    </evidence>
    <sequence length="1759" mass="194375" checksum="D9A1C00E2B8CDFC9" modified="2025-10-08" version="1">MSALKPVGVFWDIENCCVPKGKSALKIIERIRELFFTNCREAEFICVCDINKESDATIKDLNDGQINVVHINATAKNAADDKIRQSLRRFSDSHPPGTKVVLISSDVNFASDLSDLRHRKRYEVVLVHKSQVSDALLLCASEHYLYEELIRDLPDRPGAKELKDPVLVVTGYNKDEPLERVRTILKMHSNNCGGKVISIGPIFAVLKFETPELLERAKKRMTGEDVYGRKITVSLPEETPFYNTVKKLTVSHLSRRQESPSPQRRSPRERRNSNRSYTPDGYEGHYGQGYNNYGNNNNYHYSGYSNYHQPQPQRYSYSDVNAQSMGDFAFVPPQAEWSSKAYKTPGGPVKQPVGTPSYSKPTGQGLSPGHTYTLPNSNSEKYYHKSSPSSDPQPQHQHTDNRASIPGMPDSSTSKSYVIGDLSGAASGQSGTITVFKPTDSGKSLADIPIPSFGFRDIPPPSLPPTSSTSTAAAGSVAPGSSKTNSDLDPRANVFDPIKLVETASMDSLRAIGKSSTSVVPSLTADEDVTEDNRQPQTYRPHSAGRLYLPPGAPKGPVGHIPSSAVPVPQGPVFTGQPPQHSSYPSFKPRGQSVPSVPTYGPAPGGAPAPSGNHHQLSADDEICIMHGYPPPSASRSQSQGNSVFKKPASPHRQPAKHPNNSGYSPRRPSPASQRSRDMRHSVSSDGEERSYSPTQGNSSRQTFRPRLASNPVSSSRVSSSPTGRALSPLAHSVNRLKAKPHGSNLYRVPTPNDMGDPAADFSHPDFNPKLDPFVELVVSNLDYNIHPREWRKIIYATFHPHVKILSIQVRLQADNTSVATVRLPSEQDARFAITQFHRRKIGYKRINVQFKSDCSQSPAEALRADTVALLMEAKDNKMALSRLIDLFDKRFHKTVSVSDIYKMRDTIHIQETGGAGRWVKLQPGIRRSPTPVQALDSEVPEVIEQPVCTIHCAEGSVHYAEAINSCMLPSVRVLRKHFSPQLHSLLLSHNGYIPLMSFPACYSAEFQPLLVAKEGGIPLEHVISCVPGVEITVSKAGVKVIQFQENRDQFYDMMKGSSWQELGKISREVMELLRQQTTCSMPVSKFIPAYHHYFGRQCRVADYGYTKLQELFEAIPHAIQILGTGDRKAITLSPRAQLKRFTTDIIKVVKAQPAKQMMLDDFPQAYERVMGKPLFLPHYGVAFMEDVLMDIPTTTLIVIEESSHTLLALPRRDQTAEEVERTKQFSLEVVDLLRHNPQCRMPFNKFIPAYHHHFGRQCRVADYGFTKLTDLFEAVGHVVEIEEEGEERLIQLSGPELRKVVCEQLSSLIRPVGSIPINRLLTEFANHFGFCLKLEDFEVESPRALISKLRNNFKIEEQDGQECVSLVKEVHISRLGLQVMQLLMDESGGCLPLMELCMRYETLHGKTCDIEQLREDLVDYVQIDEAESDTGGVIRLTSQQMLGRNLRLLLLHHERISMSELAALYRQQYGVELSPALYGFQTLYQLLLSFPHILEVRGKPHHKYLVLSDTFDTPGMLPPARVDMPSPPHQASSPPQQQQATSGVPKSQDASNLGGPLFDNVTSKASPPSIGRTTSDLLLYAAQQWDNSLAKQMSNLGVSGSAPSPSKGSPVKVSGAHIAPTGVPIAWQMKAGEGQSPDKIMTNVMRGNIGLVNNSENQNGNVKGGEKCNLPFILGNGKLPGIKTDIDEKGDGETETAARSGSTFKLENEKEEDIFSSTEPPLDTSSAHSQHNSSSQSSSSASPIKRKTRIAANFGNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAA9</accession>
    <name>A0ABM0KAA9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Protein FAM72A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852142</name>
        <name evidence="4" type="synonym">LOC118478967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112718.1">
        <property type="nucleotide sequence ID" value="XM_005112661.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829417.1">
        <property type="nucleotide sequence ID" value="XM_035973524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852142"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005112718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829417.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15960" checksum="3F5D055FB7DD721D" modified="2025-10-08" version="1">MVLTSLHPSFGKNSVYLLDCRACGETVCRRGMLAVLVADGKTELFSTDRYDRSSVGVIPEVFTTEKCKCRIQHLGCLSCGCVVGYHVVLPCSKCLSSINNGHHCMFHSSLVSHYYRLDEVGGGCLLWRQLMGPLEDAVPATECLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB99</accession>
    <name>A0ABM0KB99_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A-agglutinin anchorage subunit-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113451.1">
        <property type="nucleotide sequence ID" value="XM_005113394.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845753"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113451.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20665" checksum="C07DDC19677151D6" modified="2025-10-08" version="1">PTSDSTRPTSDSTRQTSDSTRPHQTDIRPTPDSTRPTSDQHQTDIRPTSDSTRPTSDSTRQTSDSTRPHQTDIRPTPDSTRPTSDQHQTDIRPTSDSTRPTSDSTRPTSDSTRPTLDQHQTAPDQHQTNIRQHQTDIRPTSDSTRPTSELHQTAPNQCQTSTKPAPDQRQTKQHQTRTRPTSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVA5</accession>
    <name>A0ABM0ZVA5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101848026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="10">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.1.3.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_012935206.1">
        <property type="nucleotide sequence ID" value="XM_013079752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848026"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="11">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012935206.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22531" checksum="C919F352A9D4AE96" modified="2025-10-08" version="1">MDNAGFELLSDWCLAEFLLSSGLATSVHFHIKAMPWFVSDVTEKDFNWTLHQMSAMNHIAMSQLAQKWKQRLNDKTWIIEVDNYWTMPNDYAQMEELNPALYQQLSQADLVIFKGDLNYRKLVGDLKWDYTTDFQTSLRGFLPAPLCALRALKSNSVTGLKKGQAEVAEKESSQWMVTGEWAVLSFSSGKTTSQPCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVC3</accession>
    <name>A0ABM0ZVC3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione S-transferase theta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106011156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935247.1">
        <property type="nucleotide sequence ID" value="XM_013079793.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011156"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051369">
        <property type="entry name" value="GST_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917:SF8">
        <property type="entry name" value="GH16740P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="97"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012935247.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27493" checksum="7B51A23958AEA3F0" modified="2025-10-08" version="1">MDKTEETTVTKPVHLYLVRISPPCRIVWLYMLQHDIPHQLIDVDFNQARPDLPDAIKGLPHLEVPIMIHRDNVVFEAPAILQYLAREFTGHLGFGPGQQVRLLSESLVSWACGELHRCIGYNYVYPQFLERYALPDHEANEAMVEFSLNRVTTLLETLEKRYLQKSPYLTGQRVTIADSAVATVLVQLQWPGFSFKLWPNVLTWLHRVEHVDFWDTVHQVHSDFLGELLKCRYKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWL3</accession>
    <name>A0ABM0ZWL3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854562</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936011.1">
        <property type="nucleotide sequence ID" value="XM_013080557.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854562"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936011.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51381" checksum="29906003C5BA5C5D" modified="2025-10-08" version="1">MSESTSETRDERRQPREPQMTSSHEQQRTGDSREHNRPARTTHTHTSVSRSHADADSERRSRLLQLMTSPPSTLDMTSQRASAVRADGKTSPVSFGQVLGRKVSASPEHAGHRSVKPPSPATSQTGPASRSPANKQSKDPIAPTRNAHTFTEPVQNELRLPGIGQAMEETSLEEVSPFTYLRYWTEFTEPCVVTRPRYFDKHLLFHDSHPRRRETDQFARSLQLDSPASPSSAVCTICQDQDQIVALPDKFLLDDVPMSSLLVSWRLHTNLASPTLQMVFILLNRYSKLVSLVRRSANSACAVFETISGAERVMELLNAARGTWVLIVRWWHHSCDSQRFRHHGSRVNAVMWVKKQLTLLSGLDEQAAYKHFVDTIQRKSLLPPHDPLHLPTVLRHSRAPPFTKDTMQYSAQARLKGMLKRLAPLMQKVMTAPVTRSPSKEQGKQEDQRDLSNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXU0</accession>
    <name>A0ABM0ZXU0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC101848284</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012936715.1">
        <property type="nucleotide sequence ID" value="XM_013081261.2"/>
    </dbReference>
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            <taxon>Tectipleura</taxon>
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            <taxon>Aplysioidea</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
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            <end position="225"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="Pfam" id="PF00685"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_012936757.1"/>
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    </evidence>
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</entry>
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            <fullName evidence="14">MDS1 and EVI1 complex locus protein EVI1-A</fullName>
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        <name type="scientific">Aplysia californica</name>
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        <scope>IDENTIFICATION</scope>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
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            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
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            <dbReference type="Proteomes" id="UP000694888"/>
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    <sequence length="316" mass="35829" checksum="889FBE3E13CAAC27" modified="2025-10-08" version="1">MRKEAVLKEVVDKLWENLQRLTEERKENQVGWTEGNGEPVRETKQQREKNLKEIQKNADMAVYSLKCDQNAEKQDASKKNQTTNPAKRRRKGENSSRVTTPNVAPLGGPGVPPPVKRPKQGPPTHQSSADPIDREIQPPPSSEVPPTTKLAVSTLSPPSSEVPPTPKLTKATSFPPEVLKAEPGREIKLKDNCWFLCFENFQMVSKSEQEQLIKPNILTTAENKFACKFCADSDVDGGTTNRTFFNRDKDIKRHIATHLEDQFYVCCFCDSQNNCVTDLRRHATGHTDYRLFHCQSCDQSFIQQVSYDTHMKNHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYI7</accession>
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        <submittedName>
            <fullName evidence="12">AT-rich interactive domain-containing protein 4B isoform X1</fullName>
        </submittedName>
    </protein>
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        <name evidence="12" type="primary">LOC101853783</name>
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    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
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        <scope>IDENTIFICATION</scope>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1661"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1713"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1736"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1827"/>
            <end position="1843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012937176.1"/>
        </source>
    </evidence>
    <sequence length="1843" mass="205556" checksum="1D8376072FD926DF" modified="2025-10-08" version="1">MAQPGFGPPSLPVGTEVSAKYRGAFCEAKVKTVVRVVKCKVAMKDCQSSIFVTDEEIKGPVKLGAIVEVKHPDTGQPVEATINKLIDQSTYTVVFDDGDERTLRRSQLCLKGDKHFIESETLDNLPLSHPEHFGTPVLQNKKTKKKADDDSDDGDDASEEESPRRAMYRGRHQELVGKLMLVDLPHRKGSVIPALVVLPDANSISEVKNRDQILVRSFKDSKFLVVTRKDLKEFLRSIAIKNDDKTMRTAYEKALLYHDTKELPVGWNKEEMLGSDVEDEEDEGEEDEYASEDEPFEEKDRFVAQLYKFMDDRGTPINKGPSIGNKDLNLYKLFKIVQNLGGYNKVTKEMKWPVVYSKMGLPSLHLNPAHQIKTAYKKYLDAYETFYRKLGSTMGTLSRPGRARQNSSRSILNFRGREKSPRSPKPPEKAKEDTSSPKPKVVETPVAEKPEDNQDTASVASTEENDPVGRRMTPRRDVRGQAAKEEQKEKEKKDEAGGAKNKKEEKKEDSPKKKEELTKAKKEEKKEETPKAKKEEKNETPKLKKEEKKDETPKSKKDDKKDETPKGKKEDKKDELIKSTRKDEVSGSRVKKDLSPTPKSRKEEAAKAKREEEVAKKEERKSTRKLQKEEEKEPEKEKEEKKLVRSARKEKEEEKKEEPVLEPPAEVKESPKKRVTRRKLIQLDIRKEAEPKEEVEEKKEVAEKKELPEKKEPPAKKIATRDLKVGDKKEKDIPRTLERRDSRSSEKKELLVKAAEKKEVKSAEKKGKVEEKKPLKKEKKGKDAENEEEEEEEQESEKSEEEEESEPPKQDTVAKKDFPVGSKLKVKYGRGKNQKIYNAKVVDSGKDGTHKTYLVHYTGWNNRYDEWIRADRVVSVLDKPDAEKAKQSSPKPMVSTFSSVLKKIKPTKTSAVIKKPGSIFRTPKMVSAAKTRATRSSSSEISVLIKKPGKRITRRRSALTDSDSKSSESHMGSDLEDATGSEQADDDSNTKEEEEEEEEEEEEEEAEEMLEVEVEEESEAPKPEMDTEVPVSDSEKIPVEEPAPATVTVEEDAKEETEILSKKKEPKNSVSVESPQVISLDVPPETKIVSLEDKSLVPDDGTDLSEKVPEAPATSCVESKVVSPEVVKAEKVTVSLMEVKNAVDEIRSVVYEMPETEARESEEKEEKVTAKEEVTDDGVSNVPVDDESPKLEIIEEAEVQKDSVSESLSLVPEPVEKATDEEPPSFPPSIDQGIPQLKKIDLEPEKKEKENERSRQGKGRRKDLTKDAKKSGKIPELSGAGASDIPTLEPILEAASSVLTGKVDPSPYDFDAEVDTPWQPEITKKWEPSQKPPIVSKEGGSTSDDGVEREKKKVKKKAKKKPISPEFVVETKVEEGSASVQDTTASSGSVSGTIEEVLASPPSADAVSATVEKVPVKKKGRKKKDLAMEAKKEVIDQYENTVNSVVEAVKHSLQEAEEDGDKKPPQKKRRTKRASESDKKDVSRVSKIGKKSVSKDTLDIVDNVREIKDEKSPGKEPQTVPDCPLPVVAAPPPSSQPVDTVVPSASSSAETSQSVCLRERTESGGFLESQGFEPELERPDTTAPFDNTPPTTPEHDEAEGNGNASMHEKDSPSFSASNNVAPKSESSRPVCPSATSSSSSSLSLPASSSNIAQSKSASESPSDNDVTSTASTDNLDANMTAQHSESSGTEQDLPPASKKRKQPEELSNGLPSPKKKKRVHGTRSRTARKSPKYIGNDSSIYKNSDSHGSSSTTPNHCPDSPPSKFADMSKSPRPSKFNFSADLGEYLEGEDRCNFLISKMKEIKTIYMNLKSEVASIDRRRKRARRKERETSLVSTNERENST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZA9</accession>
    <name>A0ABM0ZZA9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane channel-like protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101853234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937611.2">
        <property type="nucleotide sequence ID" value="XM_013082157.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853234"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF24">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046805915" evidence="7">
        <location>
            <begin position="22"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="276"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012937611.2"/>
        </source>
    </evidence>
    <sequence length="521" mass="57987" checksum="4B644B125C4CC02A" modified="2025-10-08" version="1">MNATVALLMFCFVSLPQIVPQEVISEDVELGFFGELSRTIFFFGAHSNSSWGDSSFVYERPLAYLVTWCGVNVLSVLLIVVSMYMSYRRIKRAGDDGEGPYSSYSLIGWDHSVTSKEGGTMRSVAISTHLKEMMREEKATRRRSVYEKLRLYCIRVLFNAVSLCVLGGSAGLIYYVADLSIGPGAGVPEAFGDFLQKYQLTILVSGLKVIIPPILNVLLVLERYHPRTQIKLQIARTAVFYAASLIVFLGSVFSVASSCMDSPVNATQTGMSDYCCWENEVGEQLFQVVILDFIISLVFGLVFIAGRALVVKFCNATKLGYDDFDVPGLILDLVYGQSLLWLGLYSAPFLSAVGVVKQTVLFYFHYGLARACCVPPRRVFRASRSGTFFLFVLLVSLLACLVPMTYSILMIEPSESCGPFRQERWTYEVLTDRVGEASSWVQDGLRYASHPGLVVPLLLLLVLLVLYYRSKSSAHRQAAKDLRHHLQFERKVEKRRVFATARLAHGISQVGLVDAAGKNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1P8</accession>
    <name>A0ABM1A1P8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein DZIP1L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101854505</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DZIP C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939036.1">
        <property type="nucleotide sequence ID" value="XM_013083582.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854505"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058883">
        <property type="entry name" value="DZIP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032714">
        <property type="entry name" value="DZIP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF3">
        <property type="entry name" value="CILIUM ASSEMBLY PROTEIN DZIP1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13815">
        <property type="entry name" value="Dzip-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25977">
        <property type="entry name" value="DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="439"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="601"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="289"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012939036.1"/>
        </source>
    </evidence>
    <sequence length="884" mass="98490" checksum="B209C964C4DA64E2" modified="2025-10-08" version="1">MGTQFMPSSAYYGPQAPVNGYNGYPGGKNGGFSFRKRVERVDWRKIASVDVDNISRTLDFTTLQENIMNLTFCNLEAELDIRSVDPNFVKLFKLAQLTIEYLLHSQEYLAGLCASLEEKSKQSDQDVEKVKQELEEARKELTEVKKESHKRKKMLIAQQQLMYAGNESYNKCPFCAKAFMNNSYLQSHITRRHTAGTGANKDNSSTVSPDLGMGSDSGHNQMETELSQIKERLLKQEAELQEERRALLSLKNKDPRFIKSQSSENLAAPDGNENGEGGGGMSSAIMKEMKELNAKYQASQRALTELEARSGGKRSYLGDLEDDVENDKDLLKEQRSEVAALKEQLQEQLNQMSEHMQHKLTRQDKKWQKKVYQMTQQHASEIKKLNNVLESTSRSLDGSVSPHHQRQQQQVEEVLRQSREQEKVLEAQEQLIEQEISRVSEVKSLKSPGRRGHTPRGHTPRGHTPRGTTPREVIKHSSMYPSDEEDEESAAFGTGTSSLRTLDRNTGHASTLGQTGTQSLHASQFLEELRKNPTLAVMRTELAALLQEHVEKKGIPPNQTGISDQVLKNKLSMLDTQRQGHVQKYLNFHALRDHFNKVATEKAKKQLRQMTSSPRGPPPSAGPRRRLDMSPHTPRQYPSSPGGPRPGAPHPQQNLTPGRATTPRNKSPTPQPRSARQGAKTPLSTGSTTEWTSTQFDSDEDDSEDDYEDEEEDDPASVRGKAFVPSPGARLIQSGPARQGAPSPSPRMQGPKPRLIQSRPMSGSADDDIEDLIESEGEDRHGMPSPSSRLTSPKRSPGGGVSNLRDTIENKLGSRSPGAKPFGGVDMARPGTQNKTANNVGNLDEESDWDDTTAPDEPVPAGQRYGFMQLFFIRTTFYFGILGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A228</accession>
    <name>A0ABM1A228_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Agnestins efflux protein AgnL12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101862877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012939255.1">
        <property type="nucleotide sequence ID" value="XM_013083801.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862877"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="15"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012939255.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31312" checksum="F51371E5407C8320" modified="2025-10-08" version="1">MALHKALADKFRSWRRYFVIAGGILIYLPIGVPWYFGNLATYINSYYHSRVPSETDLVDPQWIFSAFFIAFSLAIIASGYISNRYGPRPTIIAALFVHSGATFLSFYAIQHSMTALILTFGAVGGVGAGLAYGPPLPVVIKWMPRRVGLASGALMTGFGGGAIFYNELVTFFINPDNIRPDVKGSRTTYFSQPELLARIPELFLALGVLTVVLQISGVLLLREPKEGDEIEEVELQEVKPIVLSQQNGDSTPQQTNKAGVVNQGLTADVTSQGLTTTDSAGDNNPSTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3S4</accession>
    <name>A0ABM1A3S4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zwei Ig domain protein zig-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940240.1">
        <property type="nucleotide sequence ID" value="XM_013084786.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849856"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047433200" evidence="1">
        <location>
            <begin position="31"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="75"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940240.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20555" checksum="61AF085DF4609A3E" modified="2025-10-08" version="1">MSWITHGLTLLNPEIFCAWTLLSLLLHTLALSGMEVEAGLADGLVKKNVTKVSSSNSGTRMVSDEQQEGEEEDAPYFLNTQRFISVFRGKMAILPCSVKHLGKRQVAWRRLETDEFLTIGKMVWSKDPRIVLEHKAHRADITSWDILLRNAKDEDAGYYECQVTSSEHLIWTLQLIVLEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3Y0</accession>
    <name>A0ABM1A3Y0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransferase family cytosolic 1B member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940329.1">
        <property type="nucleotide sequence ID" value="XM_013084875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853865"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940329.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34822" checksum="001578A2CD8AB95F" modified="2025-10-08" version="1">MASSANNQEELGPVAKFFGRSEPFYDTAGMKDESGNPITLTLVDGKLYTPVGEGCVRGARSTRLRPDDVLLCGFCKTGCHWTWETMNMILREKAEYSAMGKGQGFLEMVPLSMIETLASPRVLNTHLDFDRLPEDILKYKTKLVITTRNPKDVAVSFYHHHRDLYEMYGYEGTFSEWMSLYLGGKVDNDGFFKYHADWDRAIKEHPEIPVLVVTYEDHAQDPVGTVKRLASFLSVNLDDETINAIAAATSFHPMKSDLKSKGMATHALLRKGEVCQWKDYLTVAQSEAIDKLVETQLAGTIFAEPRYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4T7</accession>
    <name>A0ABM1A4T7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-coupled folate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101845257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940852.2">
        <property type="nucleotide sequence ID" value="XM_013085398.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845257"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012940852.2"/>
        </source>
    </evidence>
    <sequence length="268" mass="29828" checksum="F6C27377BAADAE39" modified="2025-10-08" version="1">MRAATFLMIYRVLVNVPAMFLGLFCGAWSDHTGRKLPMMIPSLGSIFAVVLYMLGLLLREHTLVIIMAGALVQGLLGKSSVITMAVNSYITDTTTNEERTRKLGKLLAMNFFGLFVGSLLAGAFQDVANLETTLVAVAVFHAASVFTVVLCIEESIHDKMPSEEGYVSEDKRHGLFSIQGLKESIRVILRPREGGKRTLVLTAFLAMFLNQTCKVGEQDVTVLFIQVGLRCHWHCSVQAKWVEIRENSTKRLEFKNVQMKIRTRAGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5Q1</accession>
    <name>A0ABM1A5Q1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101861144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101861144</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941329.1">
        <property type="nucleotide sequence ID" value="XM_013085875.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861144"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051574">
        <property type="entry name" value="ZnF_E-box_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391:SF18">
        <property type="entry name" value="EG:115C2.6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391">
        <property type="entry name" value="HISTONE H4 TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="465"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="779"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012941329.1"/>
        </source>
    </evidence>
    <sequence length="969" mass="106620" checksum="DCA2A60738F6B8D0" modified="2025-10-08" version="1">MKDKDKPKTKSSAVKRKAKDVDFQYTCEWMDCSHKEDSMNLFNHHVSQHRLAYFQQIVRDSGADSATGDFSFYCHWRDCGAQVEGKLAEFSRHLFYHTFHQYLKFLGQHIQEVEALEPCCLDSSSRNLIPELPERLLCRWDDCTMEYENPYIFYSHVSHHCEDFPKGNNPKVVIRCKWEGCQANAKSWFKMKEHLRSHTQAKVVACPTCGSLFANNTKFVDHLQRQRLVVNGKKFECSHCGSQFGSERILRDHIRHHVNHYKCPLCDMTCPSPSALRDHVRYRHSNQREFSCTLCDYKAKVAGDLRKHQQTHDRKNFVVCQYEDCGATFSQREYLLQHYTDEHQPTSGLGPYQCHICNRKFTRGTLLTDHLQADHNYKWPSGHRRFRYKQHEDGVRRLQTIRYESIEVSQEVLGHKLSPHPAVGGSNSGDGDGGGGARNTDTGSNNNDGTSDAEAGTSQLLIAAPSPCTSVDDDNINDLDYDDNDVSSSRSVSVSVAGCGEPPKKGGRGAKSAGLSKDNHGKARAGTSGRQRKDHDLAEVEESQGNVRGNPKKSRKSPRKSSSPQKSASNLPASSFTMPLLSPLKLPPARKSSSSRKSSSPQKAKDSQKRKRGSGEGGKGKASKSRKIVDPDTDDATSASSTKAEHSVASSSFFLPSFLSAAANLGFAGAETLSQASTSSSVSELSSIRTGKRIMSEDFHPDVTTSSLMSISSYGGSLKSPVESETLYTSDYEQTTSDISSDVSFPPLLEASGRINAHHVSSVRAVSVTTASPTLTSPSQEALSNSLSASSASQLHKDVSSSDNIVRLRSEFRSPTKVHTGSNFGPLSFSPEKLGFTVTDASGLEWNSSPVKVETGNVSEQGMDVVWKTPHAVDLSTSVPNCSTVEVGVSAEWTQLKEEHQSETQINWSTVHDDGMLVREMGGGETVELGGGETAEVSGDNQMYNLEMLGAVALGTRLATRKRKKSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A638</accession>
    <name>A0ABM1A638_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IQ calmodulin-binding motif-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101861972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941551.1">
        <property type="nucleotide sequence ID" value="XM_013086097.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861972"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028765">
        <property type="entry name" value="IQCB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15673">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15673:SF2">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012941551.1"/>
        </source>
    </evidence>
    <sequence length="604" mass="70396" checksum="8C7F080B8D19E0E8" modified="2025-10-08" version="1">MDTGRSTASRKGDPRIVGIAKEVSESRDRKVPALLLQLKPILNEAAATSEEGIRMRQELWQYNLLKVAVLVLRQDYSVIPGEWGAAADLALLVSQATCGLACVTSEDRRQLEEDFLPRCVENMLLLSRHIHGILASLSASRERDKEASELCASFKKVLDALVHLASGYFYICPQVLTSQWLLQLLVSDTHKVTNITMATMEKLLRLDPQLLTRLNESTLHTLMDELVYKLTVNTDVMIAAGACRCLLRFCDHHKSLVELLCLRYRGLRPLLRRWEGRGFDRDLRHMAVLLESGSAIKAKAQRRDECARYIQAVWKGFRTRRRLVQANRAFAKFHKSYRLKKSRQEQVKLQTQYQTELHHQMKRRRQQLIRQFDEKRLHALEVLPASGIEEYLRKEKSVAALRIQTLWRGHRERSRVSERQKVKRQVKAAIIIQRGVRRWLERVEQARQEFPRHFKPDGLTEERKIELSGRIKQWREQNPSRMETPEEVAERHQRAQEMLARHYGNVRRYRKLEYQCHNLLARLDTDTELVSLAPSLGDITAADVDMYSSRSLPVATAAKQQHKLMMRRLQQPWWKTLGWEEEEEVDEDERERVVAEVLLETMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6B5</accession>
    <name>A0ABM1A6B5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein Shroom2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shroom family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941655.1">
        <property type="nucleotide sequence ID" value="XM_013086201.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846675"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014799">
        <property type="entry name" value="ASD2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027685">
        <property type="entry name" value="Shroom_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012">
        <property type="entry name" value="APICAL PROTEIN/SHROOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012:SF32">
        <property type="entry name" value="PROTEIN SHROOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08687">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51307">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASD2" evidence="7">
        <location>
            <begin position="589"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="427"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012941655.1"/>
        </source>
    </evidence>
    <sequence length="899" mass="96714" checksum="FA9947BE6C64AE3A" modified="2025-10-08" version="1">METHFGAGPDAPALPAPRWRPRRGPEIPPPPTPPTSGQGEMIEVHAGDQEFPPPPPEVLQAAAGSGEKSGSGMEESGPSTAADTDGFADESYIGHKNKSSRPIGTYKRSKSAAAIQSGSSSSSSASSSNQTTMGVNDNNSSNSHSSSYQHKVLDESENTSFPEKKLSGWNSESLLMQHADRSGELHGQTFAAGVGVGVSGGAGATAVAGGVNSIQEYAGQGGGGGGIGNNFSAAPSSSISSTSPPSSSSPSAAASAVAPARPARPSMTSRQAPPHSSSSSSSSTPASFVSFSSPSSSSSLSPNNNNNNNNNSKVYAADQQPLWGREFRESPRRQPPPPPASPPFDPSQSHSRNQHSINNNGHNNNNSNSKSATSGDLPWSPAGQNETPRGADHQSETSLPFSHYSPQRRPAHQPPALSEPGMDFSRKTSSTSFPSSNHNSTATTYNSNSNSNNNASSPHLSSSPSNYPAHPYSVATSSSPTSQDATYQRTGQQAPPIPPPHGEEAPPRTLPPRDYQRRESAPVRPVPVPQLSEPHDGLLEAPPSELARRKSESSVASTPRSEHNLSDVSGSSHSRQPSQEELECDQKAQELAQELADKEHKLSEVLRLDATKKRMQYMDGLFSESLELPVGPRSERSLSTSSTTAVEMRGRERNGEDGSVELSDSAKRSSLPKEYWVSPPKAMLEMEMRRNEDVGRDLTRDIHDNSALMKQKEELLGKLHKKLEVLKEAKVVLQQEISENNQLGMQVCKLVESRCQSSSERGKFKTYIEDLEKIVRLLLNLSGQLARAENAVQALAANADPKLKKMTIDKRERLHSKHEEAKLLKDDIDKRSEQLSATLRDRLEDSEFSDYSHYIKMKSKLTIELQELDDKITLGGEQIQELKKSIPDYGGHLDASAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6X8</accession>
    <name>A0ABM1A6X8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101860678</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012942031.1">
        <property type="nucleotide sequence ID" value="XM_013086577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860678"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14553">
        <property type="entry name" value="R-PTPc-LAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047005531" description="protein-tyrosine-phosphatase" evidence="16">
        <location>
            <begin position="28"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1390"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="232"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="321"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="420"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="523"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="619"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="719"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="825"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="922"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1020"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1116"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="17">
        <location>
            <begin position="1485"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="18">
        <location>
            <begin position="1660"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="17">
        <location>
            <begin position="1772"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="18">
        <location>
            <begin position="1949"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1360"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_012942031.1"/>
        </source>
    </evidence>
    <sequence length="2040" mass="231016" checksum="F8D149C66DDC640D" modified="2025-10-08" version="1">MWWGSQFYYALLGLVAAAALQLDSAHASGPPKITLAPRDKKVLEEGTVSFFCRASGNPAPSFHWERLGKRVNARRNRFEVIEAPHISVLRIKPVKANKDNSTFTCVANNGLGEARADAQLKVIRKVDGRDDMLHGYPRIETHPKLRSVEKDRSVLLQCDAKGDPKPTVIWLKDGLPVDTSDPRIQVMESGYLQILNSQESDEATYECVAENEHGVAYSYRAMIYIKVRRIAPKFTRAPEDTRVMPGSDVNLTCVAVGSPMPYVKWRQAAQDLTGDDNIPIGKNILQLTNVVESKNYTCEASSDLGNIEHHVQVIVDALPHPPTGLRGSEVTASTIRLTWERDTKSLDKPHSYTVYYRALTSGAGGRMQEVSGITRPVVTIGQLRAFTRYSFQVVAFNKMGRSRHSDAIEVVTGELAPGSPPETVLARAASSTTVIVQWNEPKIPNGIIQGYKVFYTNKPEQPIFFWDQQEVKSDNQMTTIVDLTPNQTYTITVLAYSNIGQGPMSHPIQVLTTQGAGSQVPYQPLNLVAEAKSPNAILVKWDAPQEAETIKSYELYFNDSHYRQNARVSIDPPVQNYKLINLTPDTVYHIQVSAKSARGEGPRTPMIQVHTPPFKPEAPPEEVSGTAVSEREILVSWKPPDPKKQNGKLEGYRIFVVESGRSDFEEMQKSVPGDELTVRVDGLKTWTNYRVSILAFTKMGDGPRSPPIVIKTDEDVPGEPRRVRVEAINSTSLYAEWEPPDDKEKNGVLRGYQIYYIEVNSNDEPSPGVVEHYEDTHTADVTEAVITSLKADTRYLIQVAAYTRKGDGLRSRPRVITTKGAVPSPPRNLHVDLVQDEPPSVKLTWQRPAETHGDIKSYRVIWGPRGERYEEEALKPEIYSYSTVTLDKGTTYEFRVSAANEVDYGERAVATITTPDGAPSGAPQNFTASGLTETSVRLTWDLPARNLRNGDIVMYQVTYHKLSDPINEEDLNCTDTFVDLVGLEMNTDYMFKIKAYTSRGAGPWSNRLHFRTFGWMPPPPRNVQVRRTSDTNIEVSWDEPEAPVSGFKIYYNMFATPVMHVWQQMEIGPYTVADISGVNPKTVYAVRVQSKSVDGRYGNFSAVVTTDIKEIERDDAVQRFRVTQRLTNLVKLSWDKPKRDGVASYRLYYEGMKTYREDGTVKRVVQKLDEVKIPEQQTTWTVTNLKPKMKFEFNISAVYNDGSEGYMQHLVTETLIDAPPRVAQPQVLAVQKGTIRLSLEQASEKNGPISHYHIVVVPTKSRMAKMPSDYTLDELTSEWLSVSTPASRPYIAARFESRALPPEFYLGNNQEYGSFHNRPLDVDDQYRVFLRAYSVDQRLYTSSNFSDKISIINGWNYNKPTRRPNPVKTTDRDKGQDNPVQGIPDDDASALLTIVAPTCIGAIFIIIACAILTYFFMRKKNKAKGDPMEPESKALMIEPPPYSIDPVEMRRQHYQTPAMISHPPIPIERLAEHIDVLKASDNFKFSQEYESIEPGQQFTWDNSNLEVNKPKNRYANVIAYDHSRVILQPMEGVPGSDYINANYMDGYRKQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTKLEERSRIKCDQYWPSRGAETYGLMHVQLVDVTELATYTIRTFHMSRYGFSEKREVRQFQFTAWPDHGVPNHPTPLLMFMRRVKASNPTDAGSIIVHCSAGVGRTGAFIVIDAMLERIKHEMTVDIYGHVTCLRAQRNYMVQTEDQYIFIHDALLEAVQCGNTEVPARNLAAHIQKLTAPEPGQAITGMELEFKRLANVKASPNRFVSANLAVNKFKNRLVNILPYETTRVCLQPIRGVDGSDYINASFIDGYRYKRAYVATQGPLAETTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPSERSARYQYFVVDPMTEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQEGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKMLRTQRPAMVQTEDQFQFCYRAALEYLGSFDHYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6Z1</accession>
    <name>A0ABM1A6Z1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Torsin-1A-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101863835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TOR1AIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942054.1">
        <property type="nucleotide sequence ID" value="XM_013086600.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863835"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038599">
        <property type="entry name" value="LAP1C-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008662">
        <property type="entry name" value="TOIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046753">
        <property type="entry name" value="TOIP1/2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843:SF7">
        <property type="entry name" value="LAMINA-ASSOCIATED POLYPEPTIDE 1B ISOFORM 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843">
        <property type="entry name" value="TORSIN-1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05609">
        <property type="entry name" value="LAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Torsin-1A-interacting protein 1/2 AAA+ activator" evidence="12">
        <location>
            <begin position="152"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012942054.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="39679" checksum="26D780CFF841BD92" modified="2025-10-08" version="1">MASGSPRTRRQQKQRESERRGSDHVVDSDEEDNLTSDDSDSDDSRSTFPGSRHTKSATQSSPEFSDLSSTSPLHRKSLDRSSPRGERSTCSSKSPKNINSSSSSARHTESEAPSSGTAVWVLMAILGFLCLFICCLSGRSETEVFDEGLMPFEKFLKDIESLEKAFPAQGRRTWKTVKATAKHVLNETDPIYPSIILMGVETGNSKLASCIASEIASRFESSLGQSPAGRKTDIGTYKHLSPAEQKMKLDEAFLGAFHNSGSKSLLVENLQLLSGEAALLLHGYCDNDNAPYKNVFILLMVNISPGEMVLDVGRPSNVEAYLADIWGKGIDVDKVNALMSRVANNVVVVTREGEDVFKNKCMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A787</accession>
    <name>A0ABM1A787_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Galanin-like G-protein coupled receptor npr-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101862968</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012942200.1">
        <property type="nucleotide sequence ID" value="XM_013086746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862968"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="61"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012942200.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44654" checksum="E3649CC2B9490B2A" modified="2025-10-08" version="1">MPELYPRSLTVSAGITGSSESAPSSSNDTSSLLADLNHEQAILQLPITAFLTLLMSFGVTGNACVIYVYRTRFRKTSGSYFIMILAILDLLNSGLCIPWEIYVLSNSYLQDHPVLCRVARFVATFVYISAGLILVCVAFSRLVVLYFKIVKPLHCYSSGQAQSLTVVVAAIALCLVWPQLALSGTRTVETRIPGLYGHDCSISDQMQRSIYPILFHGCLYGVFTLCFALLTGFYMRIVWVVWRRGGNRLGEQVAHRDYTPRSSASNASDRSFGSSQNVSVASRSQAGHHHRTSVLARVGRTTRMLGLVTFVFLLGYVPFLTVHVIYLLGMGFQRPMDYSQQLLYQLCLRSYFLSSAANPLIYSILNVRFRKESMVALKSVILRLPKWIRRRIKGEHEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7A2</accession>
    <name>A0ABM1A7A2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101852647</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942223.1">
        <property type="nucleotide sequence ID" value="XM_013086769.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852647"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942223.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="18883" checksum="D616A9C866A666EC" modified="2025-10-08" version="1">MMAERGSSSGSGSENGDSRNSSSRSSASEEERLRRLFNSCDADGDGYLDGEDLTFMCRMLNMADSVGEVRQQLGLTDESRLSFHDFLRCRTRVMLESSALQQPHQQSQAHDLEAVTSPALLSAGEDTGIESDASGVMGNVQPASQMTLWPTLSSDSLGALSCTKPDSADYDSGARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A811</accession>
    <name>A0ABM1A811_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Photoreceptor-specific nuclear receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106012889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942604.1">
        <property type="nucleotide sequence ID" value="XM_013087150.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012889"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012942604.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18341" checksum="D539E1FD5C364004" modified="2025-10-08" version="1">MASLITGDGPAGKGDPDDPDENIDVTSVENDQQRTPHAHGQPTHVHPHPAALYMESAIYPPGHETLYECSARLLFMAVKWAKNLPSFANLPFRDQVILLEEAWSELFLLCAIQWSMPMDGCPLFAIPDHMPVMTNSKVSPISDMRILQDVMTRFKAVQVDPAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAB8</accession>
    <name>A0ABM1AAB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neutral cholesterol ester hydrolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943886.1">
        <property type="nucleotide sequence ID" value="XM_013088432.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858133"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="122"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="317"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012943886.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47727" checksum="CE7F936424FA4EB6" modified="2025-10-08" version="1">MTFMVFLAGVAFLNVTIYFMHWFYKSKIPEKIPEQFKVRVIDANLRFFKNVVWFLQLTGLSYPFSPLVRWLGERWLLLQQTGWPWWRYTGSSLKVRSAVLSGVPVRIYEPVESLHNTRRPVLIYIHGGAFAWLSAELYESFTSRISELTGAVVISVNYRLCPEVSYPAPRDDCVAVVKHVLTQGQGMRLDTSRMAVGGDSAGGNLSASLALEFKDKLKLQLLLVPALQPLDTLTSSAIENQRYMCESIHDRNTFQAYLMYGGLSLEHLPSLLANSHVSTTVKKQMFEYKVNHNALMVPEIIRTPDLKKRNQDCSFGEEKVWDELKDIFLDPYFSPLLADDSWLSKTPTCYVMTAGYDVIRDDGVMYFTRLLNAGVKATLKNYDEGFHNSLMFHKGPLKLEQGERILFDIVDFLKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB44</accession>
    <name>A0ABM1AB44_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cathepsin O isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Cathepsin O isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101850515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944324.1">
        <property type="nucleotide sequence ID" value="XM_013088870.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828636.1">
        <property type="nucleotide sequence ID" value="XM_035972743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850515"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021919" evidence="7">
        <location>
            <begin position="32"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="137"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012944324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035828636.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39391" checksum="C79C1FA95F916DE0" modified="2025-10-08" version="1">METAYCSTQSRGVLTMFAFCLVVILLSQTDAMMHCKEKSLTQRFLDFALEQKRAYITNETEFQRRCDIFQANLAHAQVLNKPHNSTIYGVNKFADLSSQEFQDLYLSGYKSARWHKNASDASQYLGSQMVVLPPDGLPQRVDWRDKKVVTPIRDQKACGACWAFSVVETMESMYAIQYNTTPPSLSVQELIDCDDNNKGCEGGDICLATRWAQANGVVSESKYPLTDHTDSCKKVPASVPRVAVDSYNCTSYTGKEKSMLALLASRGPIAVAVDASTWHNYVSGIIQFHCSNLINHAVQIVGYDLTGEIPYYIVRNSWGSDFGDHGYLYIKIGDNLCGLADEVSSLLVKEKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB69</accession>
    <name>A0ABM1AB69_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein KIAA1109 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944361.1">
        <property type="nucleotide sequence ID" value="XM_013088907.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848471"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056741">
        <property type="entry name" value="BLTP1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047104">
        <property type="entry name" value="BLTP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25039">
        <property type="entry name" value="BLTP1_M"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20413">
        <property type="entry name" value="BLTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01220">
        <property type="entry name" value="FSA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="3">
        <location>
            <begin position="4613"/>
            <end position="5200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1730"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1818"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1930"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2277"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2370"/>
            <end position="2391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946117.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="53198" checksum="69D41D6120BA5C7D" modified="2025-10-08" version="1">MWLLPLILSSLSLAVTSGDFIKTCDEQQHTSVSVTPTGSVSLCVKTDYKPHVFVKAGIHWFRKGEEGNGFKIDWKKDDDSNFNITIVALNLTAGRTHDLKFYPFDGTRDRKNLTVTVHVVRATPQEPAETIPRTSAPPNSRVNQANSPKEQKEDNEDREKGGARQQGEDDGDHNETHESGCPDGSIVLGKFCAVFHKKRSSMADAHTVCQYNNMSLWADGLSSSDFDILKKNVDVITVWTGQRHKINCVIFKLNKELERKINCTMQRKFFCFSARQGLDGQTQTTTNPALTHSTTPQTQTQTHKTTSTVAMVTTASTPIYDTSSSPGAGDAATTGYPPTITSTTTTATTPTTTTALTTTTPPTTTTTTTTTTSTALRSTRSTRRYFRTTTTSKHTETESTVTSARCFPPSTVRGQCPLGWLTKRDNSCVAFLMTSSYLDGHNNCSKKGGKLFSIGETERPCVADFLNNIRYVWYGADQSWCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFC6</accession>
    <name>A0ABM1AFC6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein heavy chain 6, axonemal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946582.1">
        <property type="nucleotide sequence ID" value="XM_013091128.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850698"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="2">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946582.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17137" checksum="25B60E831B4437F9" modified="2025-10-08" version="1">LAAAQEVLDSVMAVLKSKQDALAEVEDKIKKLQAVYDNSVTEKKNLERNMAVTAARLKRSSKLTSALADEQVRWEESVAMFTTQLSNVVGDVFIAAACVAYYGAFTSVYREELMTGVAMATIRELGAGGVHVAPVQRRLEDCVQELGLGVRATAEQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFN8</accession>
    <name>A0ABM1AFN8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106014179</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106014179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946731.1">
        <property type="nucleotide sequence ID" value="XM_013091277.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014179"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946731.1"/>
        </source>
    </evidence>
    <sequence length="838" mass="92409" checksum="6FA1A0DE546143E3" modified="2025-10-08" version="1">MPVGEIQIEVYESIPRHRNARKYSSDPNLVHSSPQHQNHRQGPPENGAGRDSPRHWPPKGDGYYLCSGHETPTGEEDPDAKPLHFSDISLSHLYPHSDITTKEDDVIASEDDPETCSGKDDQSRHQKQHRSWQQAGRSLKKQLTRQTRIDATTEDPDLIEVLPDDASPSTSGYSSPSGGASSSFSSSPNTNNSRKGRPTSARRKRQLSAVEEQHGGAETETVDKQDFGFTSGSHSRDTEDSNPADDKQGCEQGKVNDLKQIRSSEEKLHFVALSGGKVGKYDELFPDQAENFTSESERPDAISVTNESNQISISSKDIATLPRSKALYSLDKIAMLPSYNDLNCNPSVYSVDFINNNFDTVPDRMLPHNNSPLSSVLHYKSPTNGFLRHEPSLEKEGVLVCDEKSIKAMYTISGTGSLDSQQRTAHKLMPFACECGGKPTLKCACGRDALEKLLRQKNLLRDNIDDNQGPACQLSPSKISNKSSENSKNGTIQSINDLNLRKSGIHLSDSNNSAFDNAEFKKANGTLDENDEEVYGYGNNGLNSTINEEEDFQGGRHPKNDDSLHPREPPRSILVGNAPQKRHISNIECRMVTFSKDTIFNEGKHTKYIKECISPTDLLIRASDFSDQDDSTYDNPVFDEDDDGIYGDDELGEDYDLDENGEPSVSKPKRKFSFKHPVSRNKISANDSVLLKVSELNVPSYMEKYLTNGQGCDIIRSPVHSARSPNGPVSLDAIGGITVADPSFDVIGEADEEDFEYYRRRRQKKYGSDGDVQEWLRKLNRPRKIKICVIIVVIIAVVITGIALAIYYGTPSGTGESSSLVGSESVASGPGGFGPIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFV0</accession>
    <name>A0ABM1AFV0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent translocase ABCB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857928</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946828.2">
        <property type="nucleotide sequence ID" value="XM_013091374.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857928"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF18">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY MEMBER 11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="85"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="399"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="722"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012946828.2"/>
        </source>
    </evidence>
    <sequence length="963" mass="105600" checksum="07B283C9798BEFD4" modified="2025-10-08" version="1">MLRSCFMFLSSCKFLSTNDMYLFFFQGFMNILLAFVCLSNAAPCVQTIVNAVGAAGAVFKIIDQKPIIDSASDAGLKLSSISGHIRFRNVHFHYPSRPETKILQGINVEATPGQTIALVGASGCGKSTLVQLLLRFYDPQQGQILIDNKEIRSLNVTWLRQHIGVVSQEPVLFNRTIAENIRYGRDGVSMEEIELACKKANAYDFIMKLPNTYETLVGQRGTQLSGGQKQRIAIARALVRDPKILLLDEATSALDNASESIVQDALDKARKGRTTIVIAHRLSTIRTADIIVGIHEGKDVEKGTHAQLMESKGIYYQLYTNQTSAEIDKDILSSDDEHHTTSRRLNEHDSKRTSRVKDTSSRGDVKIDEEEEEEDDDGPANAPVSRLLKMNMKEWPFLLLGCIASFVIGCSQPAFAIIFGEASMIYSEPIDDQEHESKKYSLAFVLVGCTSLVSYFIQGYAMAVSGEALTRRIRSKMFRTMLRQDMTWFDHPKNNTGALTSRLAIDAARIQGVTGTQMGFLLMAVSSLSIGVVAAILYSWRLTLATLLILPALMGAGFVNMKRVAGASLEIKEALLDAGKAAVEATENVRTVVALSRESTFIDIVSDKLSVVKESSVNGAFNVGFMMGVSQAANFMFPAVIFGYGAYLVEEGVIDTDDIMMVFSILFFCGTLLGSASALMPDMGKAKAAAKRVISLLDQVPEIDSLSSSREHQDSETLRGSINFTNVSFSYALRSEVEVFKSLSLTVEAGQTVALVGSSGCGKSTVISLLERFYNPKGGSIVLDRHSIQDVNKHWLRSQMGLVSQEPVLFDCSIAENIAYGDNTRTVTSDEIIKVARMANIHEFITALPQGYETKVGEKGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKIVQEALINAREGRTCITIAHRLSTIQDADIIFVIDKGVVVEKGNHEELMSCKGLYYKLHKASCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG33</accession>
    <name>A0ABM1AG33_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101856320</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012946957.1">
        <property type="nucleotide sequence ID" value="XM_013091503.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856320"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15605">
        <property type="entry name" value="PHD1_Lid_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15606">
        <property type="entry name" value="PHD2_KDM5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15610">
        <property type="entry name" value="PHD3_KDM5A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047970">
        <property type="entry name" value="KDM5A_PHD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="19">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="18">
        <location>
            <begin position="83"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="296"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="20">
        <location>
            <begin position="439"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="1156"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="181"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1364"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1454"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1536"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1587"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1731"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1859"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2052"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1405"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1537"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1601"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1646"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1664"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1684"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1767"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1859"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1910"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1934"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="2001"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2015"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2052"/>
            <end position="2071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_012946957.1"/>
        </source>
    </evidence>
    <sequence length="2082" mass="231600" checksum="AB681DFECC25D478" modified="2025-10-08" version="1">MENLTNNPYVNFRSPPEAPVFTPSEEEFADPLGYIAKIRPIGLQSGIVKIKPPPDWQPPFAVNVETFKFTPRIQKLNELEAHSRIKLNFFDCLYKFWDLQGCTLKIPTVERKMLDLFKLFKTVEEEGGMEFLSRERRWAQVALRMGYPSGRGLGGTLKHHYEKLLFPFFLFKKGETVSRIPEQKPLPSDEIDKSDKDYKPHWKLNAADKQRKSKRAPKESPSPTKEELSDPTLAFKDPDIDYSANSELRKLQFFGAGPKAAVPGSKDDPEIKEEKVDNRKSRIKMAIPGAYSGADKYYCHMCGRGDGDEQMLLCDGCDDAFHTYCLVPPLAEVPKGDWRCPACVKQACSKPLEPYGFDQSKRDYTLQSFGEMADHFKASYFKMPVHRVTTQQVEREFWRLVQSLEENVMVQYGADIHAMEMGSGFPTKNTEDLLPEDEEYVTSGWNLNNLPVLEQSVLCHINADISGMKVPWCYVGMCFSSFCWHIEDHWSYSINYLHWGEPKSWYGVPGPAATKFEDAMRETAPELFEQAPDLLHQLTTIMNPNLLMAKGVPIVRTDQCAGEFVVTFPRAYHAGFNQGYNFAEAVNFCPADWLPIGRACIDHYRSLHRQCVFSHEELICKMAADPDSLDLNLAAATHQDMLSMVEEERDLRKALLDRGTINAEREAFELLPDDERQCDVCKTTCFLSSVTCSCQPSRLACLYHVEDLCDCPASQHVLRYRYTLDELPSMLHRLKVRAESYDNWNMVVRNALEAAGDEKLELGELKELIAEAEDKKFPESDLLQTLVSAVTEAEKCSSVAAQLVSKKVRTRNRQSIEGKYVAKLTLEELNCFYEQVIGLPCVIKETKSIKELLTRVLDFRVEAQEALEAETPDSEQVEALIEFGIGLDVDLPEIPKLKQVLQQARWLDEVRSSMREPNSVTLDTMRKLIESGVSLAPHPAVEKAMAELQELLTVSERWEEKARICLQARPRHLLTTLEAIIAEARNIPAFLPNIASLREAVKKAKEWIQKVESIQSVEQYAYLEVLEGLVAKGRPVPVRLDQLPQLESQVAAAKSWKERTARTFLKKNSSFTLLEILSPRTDIGIYNGGRCKKKRLKDGDKKEGDGVTDYASDDSRNSGVSILTQVAAFKIGEEKEVELMRDLRTRNMEKRHDSDAKFCVCRKPVAGFMLQCELCKDWFHSTCVSFPKSASIKNKTSQAAIMQATKEMKFLCPLCLRSRRPRLETILSLLVSLQKLPVRMVEGEALQCLTERAMAWQDRARQVLTTTEMASAMAQLSVMSQRMVEAAAREKTEKIIHAELQKAANNPELQPHLASVTQSAFGNRGDSMPGEHIDMMTNGDAGHVGHASNGLAVLTSAAKQQLLGGRNSDGHGVMNGKDFDSSKEASVGVNMDDPLSPNGGDLSPLPQPLVPAPNPMSQDIGAEIDIPSATSLGMSSEHAYSSVSKGMSIFGIDFSPDGSPRKNPRKSPLMPRQCDGPVLDVAETKRAQLEELMMEGDLLEVALDETQHIWRILQACYSRAEPNRYTDMEVSGQGLFERGRDKKEQKKKDGVLKTKEKLKRKKAAGERLSDVVIKRIKVENGMETIIKKKKMKQQQQQQQQRKKDNSGDSKEGVKGKIKDTDKTTEGGAGADVKPKLKKKKKVQGQTPAAAATTTAKTPEVGKQKEKRPKVKRERKVKEEKVAMDESDDNDEDCSAPKCLRPTGEEVNWVQCDGCLKWFHLLCEGIKKNEVSEDKEYACSKCKGGKQKAGEEASPSKPDGASSEPDFDLDKVKAEPKEGLVESPPCSPSVRAAADKAISDVVEAVAASSKERRLEAEKRVEAVESMMQLERGVPPPPKPVSPLVSGSEVVVEGEVTTTMSPAAAAAVSAASSSRVAADPAGSGNENEGQAKKDDIDDDDAVIVSCARSEDVAMEVDVNEVEEEKETGVDKPVLGDGEEEEEEEEDYEDGEEVEEEEEEEEDEEVEEEEEDITMEEEEEEEEEEDDEKTDTGAEGDTTNTADESNDIAGDSDLDEISLDKDMGSLEEAERQCAQVLGALKSGDLSAVAAAVPLPGLPVMSSSSSSPSVAVSGGEVKSTAVPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPF3</accession>
    <name>A0ABM1VPF3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477281</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824295.1">
        <property type="nucleotide sequence ID" value="XM_035968402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477281"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035824295.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12098" checksum="96860FE420862E2A" modified="2025-10-08" version="1">MVSRLTRQLNARIPDVAFTGGDNDPRALIKLCLRGGRVLEVLLGFTAAVVTQVGICLKGLHQELNDLFMSVDGSQVERCVTPVRSLIHADPRLVGDEFDHFRLATFGRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQA3</accession>
    <name>A0ABM1VQA3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable cytochrome P450 49a1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101844963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824595.1">
        <property type="nucleotide sequence ID" value="XM_035968702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101844963"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035824595.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61614" checksum="165C25E8264B7867" modified="2025-10-08" version="1">MWVTKRFFKASAKRAQLGARLEGDHHVRSEESTAPTPRLSSGGRVNSGGVAHLKPIEAIPGPGGRSPHKLERSHLVFAELHCKYGSIVKFRKGSRWSVLLFDPDLIEEASAHEGACPHRPSPPLYDVCVERNGRQKGLSQSQGLEWLRLRRPVQEFLLQPANIHQYIPALSQVADDLVSELGDNLQHSASFDLEDLALRYAIESSAVYCINARLGFLQSSPSYRNSNPDAIAGREDQDQGSHNPTTHPLGFSAEERAQLLHMVRVFMSSIAEGFYRFPIYRWFRTKLYREFEEASESISNLCQQRVRHAAKSMQRNGLSGDSPNLLNFLLSDGRLELNKSAALLGGFFSTATDNISNSLGLVFWHLARNQDKQDRLREEIARCVTSSGQVSPEEMSHMPYLKACVKESFRVAFPFPVGSVRVMPRDIALAGYHIPQGTTVYFGHNALCHSAEHFEAPEEYRPERWLKQTGSSPDPKIRRRQAICVQPFGLGPRNCVGRRLAEQQMFLAVIKVLQRFKVKLGNPQEELDIVHRISARSSRGLDIQFEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRG5</accession>
    <name>A0ABM1VRG5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477513</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825007.1">
        <property type="nucleotide sequence ID" value="XM_035969114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477513"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035825007.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14785" checksum="4818CDD5F9076B1D" modified="2025-10-08" version="1">MIDYHYGLYSQRLFNQDCLTTVQLAKILWRAFQVNGYFRTNNSFPEDEVEKAVANVDLYSASQGVTRVFTQHFRADPVSEGDWRKQREEAMINAYRDVPDELKQKIKERFHRDFLLFGYDPKPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VST2</accession>
    <name>A0ABM1VST2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101863894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035825474.1">
        <property type="nucleotide sequence ID" value="XM_035969581.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863894"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044996550" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="34"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035825474.1"/>
        </source>
    </evidence>
    <sequence length="580" mass="64089" checksum="3E9C27C0D0CC8A9E" modified="2025-10-08" version="1">MLRLVALTLCLCHVTLTVQAISLVRVTSPTSSYVGQAVTTEDGRSFHAFRGVPYAEPPVGDLRFRKPVAKPPLDGEYQALGFKPYCIQMNYMPSSFGAGQEDCLYLNVFTPGLRSSGQSSELLKVLFFIHGGGNLNGFADFYMPGSLVTHNDVIVVTINYRLGLLGFLSTNSSASLGNYGLWDQVLALKWVKNNIRAFGGDPEAITVSGESAGAIDTSVLTLCSQARGLFARAFSMSGATGVDHPMVLAREPVTMAELAARREQCLGETDPVPETDEQWAPVVECLRKVPEDRFGSMAGLGEMPLIGPVVDGDLVPNDIKNLFSDQAYLERIGFHDKQYLVSVVHNEGSIFETMLDDMRSSMTEEQLASIPPDALFYGLISELLKSGYGQVSPEVVAKVAEYYQENFEVSPVADFSADSFFIIPSLEYINAASGSANQSKAWLLRFVNFAEFMTEKNKGMCHVMDLFYLFDIDINEIKKWVDFKIDSSKWSQEDTDLKAKYGQLVSSFVKTGKPEVPKEASGKEPPTWPPYDPVKGQYLAFSSAPSLAQHLKADRLRLFQQQIPEWIQEFPLQPPSKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTK4</accession>
    <name>A0ABM1VTK4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101850170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825746.1">
        <property type="nucleotide sequence ID" value="XM_035969853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850170"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825746.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="50982" checksum="50E4958CE245FE6A" modified="2025-10-08" version="1">MDIERDADASTEDKYLETEKDRFKRNSYRVSIGLIHLVIVVCFLLSHIPLFVGNWATGHLAGWLQKKNERERFNVVQERTGNLWRECQVTNLYMVTSSNRDHASGIIDPQGCSSIVFDTTNSWVVVMQVLVLVSSVLDVLHIVALIAFCTIHSRAPAPGAYSYVAVFCRIIYLILFSTVCADNRLAHIRISKSEQNGISKEDIYLVMTRAADIDYHWGPGVIVLSIILYVTVVTMLMLIFFWKAHPDGILRYIKRPISETSEQDDSQSDSSYDSTGDEQNEIYFHTADKAETAPQPVKLSLCQQITQLICCSGGRTVSQPQRKDLDTYPLSFLQHRWETTPSQMVIQSEGSDGKPMVLRLVKASEQEDEFCSDEEDGDDEDSVTTEQGFKNARNGKKAIYRSSSGTHLWTVLKMGEKWKSEVQSKKSQQTRRTLKKRKKRKTVKFAADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VV77</accession>
    <name>A0ABM1VV77_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Trans-Golgi network integral membrane protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC101853097</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101025.1">
        <property type="nucleotide sequence ID" value="XM_005100968.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101026.1">
        <property type="nucleotide sequence ID" value="XM_005100969.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826319.1">
        <property type="nucleotide sequence ID" value="XM_035970426.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853097"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037645">
        <property type="entry name" value="KCT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16502">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16502:SF0">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045023430" evidence="3">
        <location>
            <begin position="28"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005101026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826319.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="66802" checksum="CDEB801C7AA5C39F" modified="2025-10-08" version="1">MLRKMRLSLPVVVVLVTVLLDCPACEGGPAVMPTQPTHNDKSFNASIASWRSNNCSFPSPFFYNESAEGTSNSPALSLSKCYSVLPEDPTREPLDQEDGLLYRELCTKFVKLADTLCQDKKKYEKFVLSNLSRDSLLNDVVFTLEQDSCWYASGLPKNPKSYLPGFMLNKTECDRVCSSIFEPVCQLITSALCHFSTWKGCIRPVSSTGAPAATSPTEGPHTEPGSTVVASESPAKTQEPTQAAGDTGGAGKAGTNGASGNTGTNGAADITDKPGQGVTKRPEVGKPSQRVTASPGQTAASTKSLNGAGGVTPALSGMTEKVDGQTLGPGQSTPEKMSGAEPTVPTRTSAGTPVLGGGAGGTGGGAGGDGGKIETPIPAVATEKPAIPEGNKPQDLPTDSNEENKPKNVEIPGAKATGQGEGGGQQTAGTSTEGTTKDAGNGDGSPGEDNTPQAGAGDKAGDDKKVGGLPEVVAGGDGDHVKVVGAGGDGGAEEIADGGAEEIGGGDSAGTVLDNDGSTETKVSDPGAGPEPLDGLPESATNAPTQHEGQRQGDPLPNSNGQNYGVHPPVLSDPDSPGSGHFFAYFLTAVVICISGYVIFHNKQKIVAFIVEGRHGTGGSRRRSGGPKYSQLKSNVEEVMPSLESATTVKNFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VV90</accession>
    <name>A0ABM1VV90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847433</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826332.1">
        <property type="nucleotide sequence ID" value="XM_035970439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847433"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF38">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="192"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826332.1"/>
        </source>
    </evidence>
    <sequence length="749" mass="85571" checksum="5E46B2C97CBAEC20" modified="2025-10-08" version="1">MPRTRRLTWKERFKSLVGDALQLTQQNRRASQDFTMGLLEKKTRRKSVMKSVLTKKIPKLSDLVKTSDEKPYYRFRRMARVVLMLIQVCNVCKDLMLTGVKKEPWFALLDNLVATTNIKQKRKGPRAFVTFVPNEKRELVQLTFDVTEYKRDHRTEFILTDEVRDILTLLPACRPPEHIPKIIRCMKGLFEEFNNYPLSVQKQICQTAFYDRYRHNRVIVKKGQNPDGIYFVLSGTLIEKHDLGRQPKEIRTGSLFGENDLICGSMRRHTVLTRTDTELLFLHRQDYRVIFNMSEDSNDPKNLDICKQHVVFQHFPMNRLVDNPGTWSVLKYKYGRLIAKDNNEVDWIYVIKSGEARVFKYLEPGNIDVQARRKKVQAMINSQSTFFKKKKILNFVEDRDYIKTSYSPRRYQPSSRSIMSAPAGASRDPGLAGLSNRRDVFTCIPGMRTSRLGRDSLVSAGTGQAATRRSESKRSSIASRKPDSESDDNVDDKSNRKDSMRLPKLQLSQCDDDETTTKNEAGAGEENHNEGKNEKQTGSTSVARRKSVMVCETVEDIGHLSSRDAGGGRVSRRGSAVVASGVEGRTKQPSHGASEVQHDEGRRSSGQTKGRARSGSFLKTPHSATARSLTSLKNSQSQVVQVGNHTLPAFVQVETLHPGQAFGLRACLDPEERGPSVSLVSGECEILQINKKFFMKHCDDAIYSLIRLKAKPFPSQEDLIDRLDVNMQWEEYKQQTLKDFLQRCRRFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVJ7</accession>
    <name>A0ABM1VVJ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CGG triplet repeat-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826439.1">
        <property type="nucleotide sequence ID" value="XM_035970546.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477168"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033375">
        <property type="entry name" value="Cggbp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344:SF1">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826439.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14656" checksum="B48D376D4D56096D" modified="2025-10-08" version="1">MYQVSGGKLFCKACNVILDHTRKSSVDNHMASLKHAKRNTEQEATGQPPKRQATLSMAVCRPVKSTIASEERNELCQEWVSMLAAASIPISKTDHPAVRQFLQKRVPNGGSTPQTHRPQACYLQRETKVIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXA4</accession>
    <name>A0ABM1VXA4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Ribonuclease P protein subunit p25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC101848987</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103749.1">
        <property type="nucleotide sequence ID" value="XM_005103692.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005103750.1">
        <property type="nucleotide sequence ID" value="XM_005103693.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827047.1">
        <property type="nucleotide sequence ID" value="XM_035971154.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848987"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051958">
        <property type="entry name" value="Alba-like_NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516:SF4">
        <property type="entry name" value="FI09323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="5">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005103749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005103750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035827047.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21813" checksum="4C6E4F00F0B4B349" modified="2025-10-08" version="1">MENYTKGETKKEYDPPRLFLEGAVEMKVTGGSKIRNLMGFAMSSMGDKSVRHMTWNGTGNAINKTISCVEIMKRKVKGLHQITQIGYMRVEDFWEPSIEGLDTLKVNTNIPAISILLSKDPLDSNDPSYQAPGATDVVWAGTSKRRHQFHSHKNKLAAVRDVKSAASRPKRAKGDRRDGKKSSGKKKDDGKTMETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXY5</accession>
    <name>A0ABM1VXY5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035827278.1">
        <property type="nucleotide sequence ID" value="XM_035971385.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850270"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827278.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34040" checksum="7DAE53213376BA2D" modified="2025-10-08" version="1">MERVKGPDVGSHRSKSKNWTNVLPERGCGFLWVVFWVLLVYDSPDAHPRISSVERLYITHSIGKSSTSDLLTSSKIPWCSIITSRPVWAITVIVCCVDWGYFMFQSCISLFLHEVLFFDISKNGMISALPFIGFFLILNVSGACSDFMMKNKVCSTVVLRKVWSVIGLVGAAVSIVALGFLDSTQPVAAVTVLVITVSMLGVCYNNCILCNIADIAPRFSGIVFGVVATVGFLVDQAVPVVVGVVTSRQTQEEWRTMFFICAGVYLFGTMFYCIFASGQIQDWAQDNDEKRPILNGGHTHKDECNGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZT3</accession>
    <name>A0ABM1VZT3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fibropellin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827926.1">
        <property type="nucleotide sequence ID" value="XM_035972033.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853965"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF9">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047163621" evidence="5">
        <location>
            <begin position="27"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="400"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="438"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="476"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="514"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="552"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="590"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="628"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="666"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="704"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="742"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="780"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="818"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="856"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="923"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="984"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827926.1"/>
        </source>
    </evidence>
    <sequence length="1120" mass="120422" checksum="11A8DE427AE30F73" modified="2025-10-08" version="1">MASLEGQPFTWAAAVLLCAAVLVVEASHFRGGTISWRPLGGNTVEFEFKMGWTYDKGPGCKEHLTGQYVNQPMSGNDNNFKCQKGCAGTPVLNSVNYYCMAANQKEGWEQGQDTFNYTFPSSGPFTVGYEGNAWMQLSGGRGNGAWNVATTIDLRTRSDTGRSNTSPVALSKPLFNMQHNCNHTLRIPILDPDGDNVRCRWAVNDECLTVCNALPFARLDEQTCTLTFTTGFTQTYQPGDFFAVALTIEDFPPAPITLGGSTRKTPSDSLSSIPMQFLIKTPPYPEPCDWVPRFVSPTPQERDVVMVEEGDTLNLPLTADNGKATNVKIAKIQVLGPVGLQQSALRQEVGQVNTFTKDLTWSTGASDVGEHLVCAIPEDEKGKSGSPRCFTIKIVSPYSDIDDCKSRPCQNGATCHDQVNAFTCTCPAGYTGKTCAGDVDDCSPNPCRNGATCSDLVNDYVCACAPGYTDKNCMTDIDDCSPDPCQNGATCTDQVNDYTCTCVPGYTDKNCATDIDDCSPDPCQNGATCVDQVNDYRCVCGPGYTDKNCSTDIDDCASRPCQNGGTCVDQVNNFMCLCVPGFTDKTCSTDIDDCSPDPCQNGASCVDQVNDYRCVCVPGYTDKNCSTDIDDCASRPCQNGGTCVDQVNNFLCLCVPGFTDKTCSTDIDDCSPDPCQNGATCTDQVNDYTCTCVPGYTDKNCSTDIDDCSPDPCQNGATCTDQVNDYTCTCVPGYTDKNCSTDIDDCSPDPCQFGSTCVDQVNDYNCVCAPGYTDKNCSTDIDDCSSRPCENGALCVDQVNDYTCLCPPGYTDKNCHTDINECLPRPCMNGAVCLNHVASFTCQCAPGFTGTLCQTDINDCSPDPCQNGATCHDQLNAFTCTCPAGYTDNTCVTGTECPSSSNPRVAIAPTRHGYNNSWLIANYMDDCSPDPCQFGSTCMDQVNDYNCVCAPGYTDKNCSTDVDDCSSRPCENGALCVGREVDSYIDDCSSRPCENGALCVDQVNDYTCLCPPGYTDKNCNTGQCSLSQPTARHFAFVLINQYINECLPRPCMNGAVCLNHVASFTCQCAPGFTGMLCQTGFDFCASSPCKNGGICVNGFLGFTCSCVDGWQGLTCGYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0C9</accession>
    <name>A0ABM1W0C9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase</fullName>
            <ecNumber evidence="1">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_035828122.1">
        <property type="nucleotide sequence ID" value="XM_035972229.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852355"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="2">
        <location>
            <begin position="4"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828122.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="53981" checksum="C67CC5DF5A2BFA77" modified="2025-10-08" version="1">MTIKHEVKYLDWTFSFRMSPFSGPLVYDVRFRGERIAYEIGLSEVAVFYSGFAPFMQTQDLADSGALLGTHAKTLVADVDCPASATFVNQVLWTPQTFVNQHSAEPAVYARTFCVFEFPNGYPLRRHSAYGLHQGAFYGGMQDIVLTLRSALTIGNYDYLVDFVFHQNGVIDGRFMSTGYIQSSMYSHNERYGFQISKGVLGNLHQHLAHFKVDLDVGGTDNRYHTLDIRPQEINMTLVSCSFSRKFPDRKYHQSHFEPHLLRDEQEALYQFNFDTPRYHVISNEAKKTDTGLARGYRLTLNGMSKFLQSRDQQNEPLASWARHQLAVTRHKDSELTSSSNYAMFDQLEPTVRFTDFYKDKENIVDQDLVLWLTLGMHHIPHTEDLPVTTTTGTVLSFSLLPYNFFPECPSMSSRDNVFIGHKNRRDPSQGVRVDQFNGPDDQCVSPKSTFLEDLEGDPDIVIQTNKPHLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W152</accession>
    <name>A0ABM1W152_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-Fucosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101848614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035828395.1">
        <property type="nucleotide sequence ID" value="XM_035972502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848614"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828395.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35502" checksum="F33DCDF49AF22719" modified="2025-10-08" version="1">MAESRIFTFLVLTYAIIVTVIIIYDRTVGRTAFALKVQPQSLVSEVNWEAVQAKNVSKPANHSSDESTQRPTEDTLKVNETRQKVEKEKESTGNCPLFVSTGLNGRLGNQMFEYAATVGVARSQGRIPALLTRTSDMQNAFQITHARTFNTSHGCDSWQAVSDKHFGIFEIGLTKLPKKNTTLSGYRQSWKYFESAQDELRKEFTFKDNITADAKKLEAEIRRNFPNRTDDLKWCAANIKRPDVHVLSSASPQLHLAFLARTSHAVISAGTYSWWAGWLTGGKVIYFSGYPGNGTFLMNDFKAADYYPPHWIGIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1J6</accession>
    <name>A0ABM1W1J6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Folliculin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20 21 22 23 24 25" type="primary">LOC101850300</name>
    </gene>
    <organism evidence="18 25">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20 21" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the folliculin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091001.1">
        <property type="nucleotide sequence ID" value="XM_005090944.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091002.1">
        <property type="nucleotide sequence ID" value="XM_005090945.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091003.1">
        <property type="nucleotide sequence ID" value="XM_005090946.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091004.1">
        <property type="nucleotide sequence ID" value="XM_005090947.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091006.1">
        <property type="nucleotide sequence ID" value="XM_005090949.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828535.1">
        <property type="nucleotide sequence ID" value="XM_035972642.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828539.1">
        <property type="nucleotide sequence ID" value="XM_035972646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850300"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1730">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044886">
        <property type="entry name" value="FLCN_DENN_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032035">
        <property type="entry name" value="Folliculin_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16692">
        <property type="entry name" value="Folliculin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="17">
        <location>
            <begin position="74"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005091001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005091002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_005091003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_005091004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_005091006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035828535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035828539.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="64551" checksum="8360FF64D4FC8D1E" modified="2025-10-08" version="1">MNAIISLCHFCEFHGPRILYCTQPFRPQESKQVEGDEAEVSISHRLKSTSIGPSSISDSHVASSLILSAKDHCEGCKSVHTGYVSHDEDAQVSYVSTQQPYNPEVFTRIRQACIRSLSVEVCPGRVGPIFYGDKQYGYVLSYTFSIPDNQARGMHRSFSILVVMMDKIYLLNSWPFLVPHLRIVIENLQNKAQKIYDQEEAKCPQRPYRLGARVDPSNFIKQRGGNKPARSLQELTGDKNVFRMLHVAFLWILKACGNRISETLLEGPPTEDTIIDMEKQEETEEGFIKIYTRKVDESPENSPVGAEASVDSSTEAQNNGDEENEDLFAPVIKNLRHLKKVVGSSKFLELAHHVVVGNQVIVSGRQRPLVKSFLTALKSLLPKGCCRVTPYSKEYEESWKCNFLGLSPDVSLSQHVTSSEMFYLVEIIKRSPAPEEEGPISMDPSSLSGPESDASEASSEDCLLRNYEFRMSSPVSLPAKVPTVLEKMMMALQNENLCPEVVETAITCLKEEWMNKVKVLFKFTKAGGNRSEEDTRKLLQIVGARDEDKQLLKFWMTGLSVQYRTHILASSAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1S4</accession>
    <name>A0ABM1W1S4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein patched homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118478673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828617.1">
        <property type="nucleotide sequence ID" value="XM_035972724.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478673"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF1">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828617.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11901" checksum="93B5347937BA219D" modified="2025-10-08" version="1">MSNRPRRADPSKSDPELLTRTSWVNAELAYRQVKRGRADGNTCALWLRLYLQRYLYSIGCLLQLHCGKVTFLGLLLLSLCCVGLKTGHLETNVDELWVEGTCGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2A5</accession>
    <name>A0ABM1W2A5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106013440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035828798.1">
        <property type="nucleotide sequence ID" value="XM_035972905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013440"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="206"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828798.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="32612" checksum="5D7652F7DE80F4FE" modified="2025-10-08" version="1">AAAAATVASQANAVAATAAAGGGIVGAAGVPPAAVAAPAASVGVAPAAAVAAPVAAVAAPAAAVAAPVGVAAGGVAAAGASMMDNMAIDDILVSAYGMGPGGAANYPMASKQVNGKFVLTALDMQLTPQQFAELHGSRRLADKSSYRLLDHFHELFNKTGMDYPMASKQVNGKFVLTALDMQLTPQQFAELHGSRRPGSMGRFKRKALTSLKSRWPGGVVPYELQALGFNAQDQQQIVYAMTQWSANTCITFRPAQPTDANILVFREGQGCSSNVGMIGGRQFLTLQKECRKPKIILHEIGHALGLIHEHQREDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-07-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D6R081</accession>
    <name>D6R081_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Adenylate cyclase type 9</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">ATP pyrophosphate-lyase 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Adenylate cyclase type IX</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Adenylyl cyclase 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27 29" type="primary">AplD</name>
    </gene>
    <organism evidence="27">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="27 29" key="1">
        <citation type="journal article" date="2010" name="Proc. Natl. Acad. Sci. U.S.A." volume="107" first="15607" last="15612">
            <title>Serotonin stimulation of cAMP-dependent plasticity in Aplysia sensory neurons is mediated by calmodulin-sensitive adenylyl cyclase.</title>
            <authorList>
                <person name="Lin A.H."/>
                <person name="Cohen J.E."/>
                <person name="Wan Q."/>
                <person name="Niu K."/>
                <person name="Shrestha P."/>
                <person name="Bernstein S.L."/>
                <person name="Abrams T.W."/>
            </authorList>
            <dbReference type="PubMed" id="20702764"/>
            <dbReference type="DOI" id="10.1073/pnas.1004451107"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="27">CNS</tissue>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="HM030824">
        <property type="protein sequence ID" value="ADG63465.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191662.1">
        <property type="nucleotide sequence ID" value="NM_001204733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D6R081"/>
    <dbReference type="GeneID" id="100533456"/>
    <dbReference type="CTD" id="100533456"/>
    <dbReference type="OrthoDB" id="10035433at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000008">
        <property type="entry name" value="Adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000014">
        <property type="entry name" value="adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF8">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
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    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
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    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="9" id="KW-0677">Repeat</keyword>
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            <end position="112"/>
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    <feature type="transmembrane region" description="Helical" evidence="25">
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        <location>
            <begin position="708"/>
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    <feature type="transmembrane region" description="Helical" evidence="25">
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    <feature type="transmembrane region" description="Helical" evidence="25">
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        <location>
            <begin position="924"/>
            <end position="944"/>
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            <begin position="336"/>
            <end position="463"/>
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            <begin position="1004"/>
            <end position="1144"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023239"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00070496"/>
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            <dbReference type="ARBA" id="ARBA00081225"/>
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            <dbReference type="ARBA" id="ARBA00081232"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00081427"/>
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        <source>
            <dbReference type="RuleBase" id="RU000405"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50125"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ADG63465.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="NP_001191662.1"/>
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    </evidence>
    <sequence length="1197" mass="135100" checksum="6233FB6CE6114747" modified="2010-07-13" version="1">MANASNGEPSKKETCVNFEQGSGLESDQVEITIHTPSKVHKRKKQGCQFLPKPFERSNGSLLNPRFDSEILESFLVKCYLPQTRRMFRKTVHYVAVASFCWGLYFALMQIRYPTEHCIYYIVSAAVLLLLMLGFSFFTRTRHFANYSKIVSFVLAILLVVTVQLPYVFDDPDILPIGTFCSVVEILILLYSFFPFNLFTAVGLGGFLSITYEVFTALRYDKMQEVSFIICKVLLHFILHLIGVFIFITSNTRLRSNFSKIGQSVSAQRDLMVEREIKEKMIHSLMPPSVAKSVMATHPAKDEEDEEENSRRRRKTRHVRGEIIFRKFQMDEMKNVSILFADIVGFTKMSSNKTAERLVGLLNDLFGRFDKLCNASGCEKISTLGDCYYCVSGCPSPSPDHAKCCVEMGLSMVLAIQAFDEDHNEEVNMRVGVHTGTVLCGIVGTVRFKFDVWSNDVTLANIMESSGEPGKVHISESTKAFCEDEYEMSEGEEVPDMRGRKELIEHYDPEQSSFTIKHREETKNIKTYFITGRKPNRTGIPGLEQLALERPEEILQQLRQQLKGQQGNESPNPAADGHVETANARTPVPGEGENGGSAAAADLFSQRIPDIMAADDETETQDKTAEEQDARVDSTLLKHSRTGSVTEEQDKLLISLIEKENEENEAFFKPSLHKYLLTFDPELENAYRHEYKDSHLFQENMLSSPRYQAAIESGIALLLLVVLAVCCHIMFAFSRTPALSALTFIGILLQTVFFVDTISNIICLESKLKKFPGLMHFTLSWYFRNILGVVSATVPAALVYVSLSCDLVVDDNWHDRFLCFALVVSLLGFCNYVMLRSFLKSFVAILVGSILIVLLFIHLCSDRWAPLPSTSSVGGSAAPLPGISNISSTVASYVLNSTMNSTVLPPPSLFIMPISDHLFSGENRLRFEIILSILLLLLLVIILNFEFENSYRLNFNASIKAQKDKENMQLNKDQADWLLHNIIPAHLAELFKTNRSYSRNHADVGVIFATIVNFNEFYDEMYAGGREYLRVLNELVSDYEVMLSEKRFKDVEKIKTISSSFMAAAGLNEESRAQNKDKYAHLYALMEFAMQLQEVVDNFNASIFNFDFVLNIGYNFGPVTAGVIGTTKLLYDIWGDTVNIASRMYSTGEANRIQVPEATADLLAPMFEFSYRDEIAVKGKGTMKTYLLEKKRDGARWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-03-01" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q8WSF9</accession>
    <name>Q8WSF9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="21 23">Non-alpha nicotinic acetylcholine receptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC100533245</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2006" name="Cell" volume="127" first="1453" last="1467">
            <title>Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Edwards J.R."/>
                <person name="Puthanveettil S.V."/>
                <person name="Kohn A.B."/>
                <person name="Ha T."/>
                <person name="Heyland A."/>
                <person name="Knudsen B."/>
                <person name="Sahni A."/>
                <person name="Yu F."/>
                <person name="Liu L."/>
                <person name="Jezzini S."/>
                <person name="Lovell P."/>
                <person name="Iannucculli W."/>
                <person name="Chen M."/>
                <person name="Nguyen T."/>
                <person name="Sheng H."/>
                <person name="Shaw R."/>
                <person name="Kalachikov S."/>
                <person name="Panchin Y.V."/>
                <person name="Farmerie W."/>
                <person name="Russo J.J."/>
                <person name="Ju J."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="17190607"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.09.052"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF322876">
        <property type="protein sequence ID" value="AAL37250.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191486.1">
        <property type="nucleotide sequence ID" value="NM_001204557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8WSF9"/>
    <dbReference type="GeneID" id="100533245"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19032">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000038">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 21 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17 23" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17 23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022251907" evidence="17 23">
        <location>
            <begin position="20"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="28"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="245"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="400"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AAL37250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="NP_001191486.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="62535" checksum="3D3F011D78605C91" modified="2002-03-01" version="1">MAISIVLTLIAVLSSRTEGALDERGENEKRLVYDLFDKNGYNPLIRPVVNTNDSLSIRFNLALSQIINVDEVNQVMKTNVWLQIYWKDYQLGWDPSKYGNIDSIRIRPEKVWVPDLVLFNNADGNYEVTYKSNCVLYSSSNINWIPPAIYQSSCSIDVEYFPFDQQICEMKFGSWTHKGDALKYSFYLNMDKLDLVDYLKSGSWDIIDCPGKIVTIKDEVTGEEKDQIIFKFVLRRKTLFYTVNLIIPCVLISFVSICVFALPADAGEKITLCISVLLALVVFLLLVSKILPPSLTIPLIAKYLLFTFIMNLIAILSTVVIINRNYRTPRTHQMPNWVRVIFLRELPKYLFMKRPDHDDRWEGKPNTPPPSFPSTPETRRVNISRNNDLLELTEVHHPHCKLNTGGGSSSHNHKETRAGYSGESTMHGYGSQPTGYPNRPPPPVPQDSTDSTQVQMTPELFQTIEAVKFIYNHLKNEEEYENILEDWKYVARVLDRLLLIIFLLVTLSGTAGILLNAPHIIEYVDQDKIIDELLAYIEEAKTRAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAP6</accession>
    <name>A0ABM0JAP6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Betaine--homocysteine S-methyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858316</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089330.1">
        <property type="nucleotide sequence ID" value="XM_005089273.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858316"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005089330.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38867" checksum="A5D831DCD58C2AB3" modified="2025-10-08" version="1">MNHQNSTSGLLERLQNGGSVVVAEGYVFEFERRGYLKAGAYVPEVVLDHPELVKQMHEEFVHAGSDVVLAFTYYGHREKLRLIGKEDQLAAMNKKALALAREVARATGTLFAGNICNSTIYNRDDKESQTKVAAMFKEQVEWSVEEGVDLIIAETFQEVGEALLALEVIRTYGKGVPAVVTLCPAAKSMTYDGVPFGEACRRLEEAGAAVVGLNCNRGPDTMIPLMREIRKACKGPIACLPAVYRTSDESLTMQSLRDPCTGKCAFPTDLPSHACSRSDIERYARACREIGVNYIGLCCGSCSHYLRIVAEIYGRTPGASKYSPDMSEHYMFGDKSKFSEYSTKGLIEYANGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBF2</accession>
    <name>A0ABM0JBF2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101860216</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089801.1">
        <property type="nucleotide sequence ID" value="XM_005089744.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860216"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047122841" evidence="1">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089801.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14139" checksum="F295D4E692032EBC" modified="2025-10-08" version="1">MGSGSRLVCLLLLSMLALAAVSASSLDQTRSRRSLQAADSSDDMLADDWAASVPTDDLLMRLGEGREKRGWCRPNMTFNSILGRCTYVYSKLKGGRGKRGWCRPDMIFNPILGRCTFTYAAIRNRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCP2</accession>
    <name>A0ABM0JCP2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Novel acetylcholine receptor chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101851782</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DoxX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090646.1">
        <property type="nucleotide sequence ID" value="XM_005090589.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851782"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040399">
        <property type="entry name" value="TMEM35A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13163:SF0">
        <property type="entry name" value="NOVEL ACETYLCHOLINE RECEPTOR CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13163">
        <property type="entry name" value="SPINAL CORD EXPRESSION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005090646.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18748" checksum="7AC4D0B289BD25AA" modified="2025-10-08" version="1">MASVVLKVLGLTLGLFFIFVGTIKLTPSVNGEIYKEMRKTYIRNSKVFPLVKQTGWKPNPHTYRKTVGSTEVICGAFLAFLPGPLKEAANIFLLLITLNDIYAHYALDEGLDKMSPAIVFSLLLTCRLVIFLQSLAAEPKSVFEKSQLDSSVAPPTNRGDVRLDDKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDG3</accession>
    <name>A0ABM0JDG3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101847170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091172.1">
        <property type="nucleotide sequence ID" value="XM_005091115.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847170"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005091172.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="68726" checksum="B89CAB3C812D6EC5" modified="2025-10-08" version="1">MSTDNVKHFRKRNLFSVFVGHLHEDVSKSDVYKLFSGCGEIVDYCILEDGSGKSRSYKYGFVRYAFREEAMRALKELNGWTLMNVRIVVDVAKDTVDLMKKAEEPASGPDLLHLDPHDGPEKDTTPSCLDKIINLSRVKEACHMMDVDRPVHKGAIRALQLIDTVEMTGGAENLRVHCRPVSSRTQLSMKRVSCELSKWEQDKGIDNCQLSKMFLAKSMEISETVSRLLDSESSELVNSSSKKLRDGDLDLPTATVDGSKKMQQSKLKSSADSAQEEACRFLELPKCIGYSLENSPQAKSSSNSILQSSAVCGKTVSDVAELTGGRNELNTRKEKSYTERYSCPTGSQNFCEQKSQRGSTSKRSLKVGGKKSPQGLSPKKNPKGIDEQSIVPSKSVPSPLSEFDSGRASSSDVNDEIGSKPRRSLSDVSSDGNDEASKPVVAGETLLSLGRALREKMKCREELCPVVDVRVCGPLPSPGKKHSNNGMLKNWMGGLGKQNGVNRRILNESEEDVEWDSPRLGNRKEAIRMASELFCQSLANDYPADTVSSSSFVNGGTETSSEKEHSAECQLSVKNNDDDSKVRVGMKSLLDDSSPLKLQTSALKSSKLAALLKRSQSEQLPSIIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDG9</accession>
    <name>A0ABM0JDG9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Trafficking protein particle complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101848407</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091178.1">
        <property type="nucleotide sequence ID" value="XM_005091121.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091179.1">
        <property type="nucleotide sequence ID" value="XM_005091122.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848407"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005091178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005091179.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16757" checksum="F782A8AAED31987D" modified="2025-10-08" version="1">MAGNYYFVIVGHHDNPVYEMEFSPPNKPSEKRDDHRHLNQFIAHAALDLVDEQMWSTNNMYLKIVDRFNEWFVSAFVTAGRMRFLMLHDVKNEDGIKNFFTEVYETYVKFAMNPFYEINTQIKSASFDKKSQFFGRKYLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDZ2</accession>
    <name>A0ABM0JDZ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Involucrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101856780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091491.2">
        <property type="nucleotide sequence ID" value="XM_005091434.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856780"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940:SF1">
        <property type="entry name" value="CIBOULOT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940">
        <property type="entry name" value="TETRA THYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005091491.2"/>
        </source>
    </evidence>
    <sequence length="350" mass="39637" checksum="F7A2B6EEE4E5A517" modified="2025-10-08" version="1">MSSNKAPSDLIKEINQKDSTKLNHVDPKEKNPLPSAEDVQQERLHQDLLNGVSQFDPSRLSHAKTKQRHILPDTGTIADERQHQSHMGNIAQFKRTSLKRTESQEKGCLPSQEVIVQEKTEAELRDRIGTFNKEQLKPTATEEKGVLPSPGDIQHEKVEVELRERIGSFSKGELHHAQTEVKNVLPSEQDIQHEKVEVELRERIGSFSKGELHHAQTEVKSVLPSEQDIQHEKVEVELRERIGSFSKGELHHAQTEVKNVLPSEQDIGQEKQEQELKNSISSFKRASLKHTETQEKNPLPPSEAIQQEKKETELRSSIEGFPKGQLKKAETTEKNPLPTKEEIAAEKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE21</accession>
    <name>A0ABM0JE21_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Transmembrane protein 248</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101852000</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005091558.1">
        <property type="nucleotide sequence ID" value="XM_005091501.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091559.1">
        <property type="nucleotide sequence ID" value="XM_005091502.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852000"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039493">
        <property type="entry name" value="TMEM248/TMEM219"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039587">
        <property type="entry name" value="TMEM248/TMEM219_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16002:SF4">
        <property type="entry name" value="TMEM248_TMEM219 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16002">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 248-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14940">
        <property type="entry name" value="TMEM219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM248/TMEM219" evidence="7">
        <location>
            <begin position="9"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005091558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005091559.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41058" checksum="C26029025B2E89FD" modified="2025-10-08" version="1">MAFTIVENLRGFFNSRPPLVVFMLCLASFAIALITFAYIVKAKDIPDPDVSVDWNTFLEKFSHLQFCLPQNSSFSQNSSAVPKLGLGEKNTAEVFQSIHEKLGQSLIGGSNSESDDSGNEDPEVTPSSETFNGISKRAASTGLSLSADNRVEAHAPSASASSSRKHLENATVSLDFVFIPTKDAKAAPHLGFGQFMAMVTAHMLKLDASFKVKGDEQMSVFLSFPHNLTRSMCEEEEGGRCRQYRVPACITFQSPARLLPRTQKPSREACPSHSDRIFDRAVRNARAGTLTETTSRDWCIHGSRLVPQFSLDDSLTVLLSMHDKSVINLHLMRTSYFLFVMVVTMFCYALIKGRPSKVKAVHIAYDKISSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFF1</accession>
    <name>A0ABM0JFF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860237</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092457.1">
        <property type="nucleotide sequence ID" value="XM_005092400.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860237"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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</entry>
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</entry>
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        </source>
    </evidence>
    <sequence length="3226" mass="361767" checksum="7542240232C29BBC" modified="2025-10-08" version="1">MDHSDRGSPDLSLFQWLQLAPANGIVFGVFTAGLAFLMLLSYLHNEDALQAQGNPQCNKSKKQIEARHRENPVSQFSGKTPNKRESKPKERGELSLPSPQGNGNWAQNGKASFLTKACQDEHPSYSNKFNSPPRNSQLNKVTSSTWGKTGHGSRYSSLSSSLYPTARAEKVDQKDLLGRIVRLENKTSKMDFEKFCTPEVSPVSFRKNIDSLSPRGIRAHREGISRPYQNLLDPQRRREHFNRDRMGSFLRRYPYSERKYRNDKENASSNKPYFTLTDQEAVNLPKVRNKTKSAFAKSPLRTNRTPTKEKVIPRSSSPKSRNTQGTCSSAESQGSSRIDSPSFTAATSPPVLSGSTVDADNQECAEELRVRLPQRDNFHMEITCMKLKPGDKEVLMGRLSQAGSPVNVESRSPRISAHNVDVSGTHSEESLALGIDANLQRAEHPEQDGDLARGGTASRNKRRSRSSVSSTRQTDKDQGQRKCSDCRQDQCTLPLCANFSQEENPANAEEVDGEHTWFRKAKIPLEQSVSPKSSTVMKGPLVDKHQRTRYLQLEELEPIKTSSVRERGKSRLHRPESFQCNVTAASSPSKDVYLLAGRHRVRPLKLKEKLLHNVVKCDLSGDSCGEDDLPDRKIRDALGKFHKHGGGPTIGRWQKGVTTCKKRWNQLKSRSTDSEIGSSPISEKPKSKRHRSVVKDEQGEVTEFAKKLFQPYFQHRPQYNKNGYDKVTAVPATASKLKGRKRRKKQADEEEPYYRPFDAQTSESEDDLRTLTDDLLPPLITYAEQKNTGNLDDTNAGQKRHRVHSPADAVKGGRKSTSPDIHYRRQLKSEVTRSSDRIKMTPRSADPDNPRQFYAGAQTRGHYDFYPDVKDRLDCSSQVIQPRASRVIPLSTLPATGRRKKYGKSGNALPAPPSLMQIPPSKETLVKLNSNVKLPTEDQRVVFMTRSVTDKEQKKVRTFTLQGCSTFGSEKGNTNLRGRELEDSHVRPNTMVTGANSNSHRKMQRHQRDQTHWSSRSKRHRARSNEVNLEACSGELNSLIRSTIRDENHYHPNTTEHRQTEIWERCKFDSNLYSPMRKNPVPGGYDIVEVGEAKVLISPIDNSRQNNSDGIPEQITYSPGAAKISFPKTPRKRKNDLKYVRSNLSPDFNNVQFHVQNKEANVEDRGCHLNPQTRLCFPKTHRKRLKFSEEKAISNSNQALLKKSNDDLKCLLTTICPDKFRVLPCVSKRGKVPFGIEDTSKLITRHMDSSQSDVGSKGLKFKYNTKYSVQNSTKCLLATCPAETGLLHNRVPISAPGRMPEGDNHQKRWQDTNTQVPQHTDLIFVQNPNVDKKKEKRDRGHGTSTRCELMANLAGDTSEYTGSNGFQVARLAKLMTVKPSPAAFRSHSTTIVEIEPRKSACFRSGLDRYSTLEQIGFVHNRQLCPTLRDSKHCSVENETYIENSVPSNHEFQHPFDEGVIPTKLLKNPKGLRATCRGKLWKEKARREVPTNKPKANNNTLSLPNVSASARESSPSGGEKLFVKNPVEGKCFPKDKARKRFCRPKRLSKYSLDKTLQRYRLRSQDQSSCNTTKPSTGQNQTLKGCTLKRKRVSGIPRPTFPTVPLCESSSDIKSTSLDRTQIPVYSRLNLCKYINGLKDKTPLALEQTLGSESSVTSHRKLVCLRTGKKPLVPKHVERNQRKSSRDVSGYQHGLYVVKIQSEMTMSSTVSIPNTAQHQVDLHSKTLCSNQNVLARHCFTRSQRVYDNAANTYSRSRSVLGKLIPLEAPGDRKAPKTPHGLLFDGHLLYTLQVSSTDPVCSDTSQSLMNERNGISCIPSRCLSYYPSGETALNVNGELGKTAMAVVVQSASDEISNTQHASDSELDTFESSRVDVSVSDSQWSTRPLLSYSFLDEIEGDGYFGEQGAVGNNISDLSLDWCPLSSERQRVAEDDYLEDETPGKHSCRTWTFHDSQPSIQLDSEQVSYMKIIPKRKGVNGFKLSRLSLHNNRQKSGRLRGTQDKGKGEDWAVTGTTTSLPSSVPSFLGSASRDSTIPASSSSNGIGTRINLKAPKDLPSSTLSVTSASPPEYQRTRLGGKRRSAWKRKHAARRQLSRSIARSLTTYIKKPKRVDKNVLGCAIRNPTGDYLPLPLAQGARYTPLAQTCQAQTPLPNLPDAEGDGIAVVEAEAKEWMLKNNGQATERMYHAVDQQVSCRLEEFIPPTDMHMVTQLERVIRMSHNQMSPARPQQHTGCLHARSSNSCHDDLESESPQSNKNSKILESESENLEILNKTKLHFSEREKADTLVTKTQQNSHKNTSNSLYILDFGNSPKRGSSPELSIITVDLQEVTQHAESKKKGKYYEQAEDQQVDDPAKLSKYDVSRFQSLPSGDFPLLHTLSTAENCLVQKKRETHNNIKTNIKRKSKYKTPRDISLSNRSSDFFRPQTILQDFTRKASTIKPKPKPRRGAASLIPVRKKTEQISRSSLKKKTSIESIQVSKGFTTPTKGRKARGVPTAHEKRLDQNTVVKHMLDQESCSSFQTHFSQKPVNLKYPLSTSIASKHDQLSQSKKRQQCRKSKSRSNPIKPFQIPSKIPVPVRTISKSVEVNTLLRGTFNDQQPQSAHTDYMDQQVSQKVTTDVTLDSAPDRHKRASRIPVPINYASSKALMTKEQVDTSVQAGLSLGQPSTTNSTIRGKDKCLDMCPLLGIPLHTLGLFNQHQIFCTSPPHMGSCRKGNQDYNMTSMLTSASKGSRYHPPPTPLVFYVQNENLNKSEAKNAVNVEKQKLKALPASSDKSINIEGEGDMSALLLDVSKSESAKSPIIQSMRSAGEKSKENMNLHETSSEKHTRSKDSNLLHEVQKNKEAKENKSHPRIRNFRANKTIPVAKFRETIKKIPAPDTMPTPVLAKFDKHKQSTQTSRKRCRIAGRLAQRVSEDPCVLERERLTAGRQISDHLQQKQLKDDIDKQTEYPKRPPEVRNNKDGHNEMASPTSVSPYPAHAEENMKLLISALRSSETPTQSRLRQAKKKRKAAGPPLLHTSVRSRRRNKSAMTGENMNESRWRKKTMTQEWTVSQEDHQSVQAGRHDAGKTHSRKVAPLTVANVERKPGGILEKTIRFSGPRPIPTSHFTRSSFCSNRVNDTRQYFVSPSRCAFESNDNKGDAYSSFHLSELPNIPGSASFEKLSSVKTPPDLVDIELSLETSGLHCVSSHAAIDTMADVSESMLDSHHIQGAQHHGLNRNSPTSNYQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHW8</accession>
    <name>A0ABM0JHW8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane and ubiquitin-like domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094020.1">
        <property type="nucleotide sequence ID" value="XM_005093963.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858332"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17057">
        <property type="entry name" value="Ubl_TMUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040352">
        <property type="entry name" value="TMUB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557">
        <property type="entry name" value="PROTEIN C7ORF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557:SF5">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="363"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094020.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="58445" checksum="D0A4D1B2A8E77806" modified="2025-10-08" version="1">MPLIEGLGDEVTLVLGGFLLCVILMLAWFSTHTSEIPLLREMGVIVVELSQRRNRATEPAQSENRERASPEGQDDSVPDSSFGEGRSEEDVSVSDWSTDGVQTDTVRNSGTSVVPTGATPAEGTTIKSSSSSSEASCPSQQSNAGATNSAVSLPTAAEMVTAECERQHRDKDDIQGDNQFCNRSAEKMPQSTDGPVPVATAVVDESGRLEGSELLEHPSEEEIRRRRVQYFQTSSQSSIPLSDIIGDSPIAGQRMPASQTPSERADELVSSTPSQTSHLCDSMDAVKEPVTNSSRPIASSLSDGDDQIDRLPGDSRQLQGASVASSSSDCGDGGVSTSDPSPQTGFVNGTNEAPSNDSQSSRIRVKLKYMNETQRLVHASPMDTIGDFRRTHFQPELQENKWVRFIYNGQDLRDDARTLQACNISDNCTMHCLITAHTRPTAPRDMVGDEEGEDSVLGALMYPLFTLVLLIVWYFRFTYRQYFSAMSTVCLIGISFLLALSYISSLRSRDAGQQQQQRQQAATGGRQHPQQNHPHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIG8</accession>
    <name>A0ABM0JIG8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate sulfotransferase 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094388.1">
        <property type="nucleotide sequence ID" value="XM_005094331.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859087"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052654">
        <property type="entry name" value="CS_Sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723:SF0">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094388.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40287" checksum="37FFD75F85BD46AE" modified="2025-10-08" version="1">MKPHALYYNKTGGGRMSTKAETTKLGVIKQNTAHDEEFSCAGLNVNRQVTPPYLPEFKNPCWRQRGANGTLLCVPYVFLAGEETVALFGYLCVRVSNMFLAGFPKCGTTDLHSKIIAHPLVSNLSRKEPHFITRNIYKDRACAPGSEELVDSSASTAWDNCHWTSIQAQDNCTDHLEYFTMAPALVARMNPNTRFIMILREPVERAFSNYAYFNANLSLADFHDSVEGFLQTFQDCCIHHSLKTCAFEMLSHGHGRPAVSLYHVYIREWLAVFPRENFHFVRLEDYHKDITSHIRDVYHFLGLRYREDGRYSVNFMWKVSVKREIRSISKDSPSNHQISGDARYLPAGELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIJ0</accession>
    <name>A0ABM0JIJ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094423.1">
        <property type="nucleotide sequence ID" value="XM_005094366.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847942"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094423.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="66587" checksum="FA2C22095FFBD01B" modified="2025-10-08" version="1">MSMDMASIKRRDSYIVKVEDLLRAVNEDDTEKAQHLLHSGICNVNWADPTGATALHFACRSGNVDTLRCLLAFDPDVDAVTKDGTSPLMYCALHNNIAGMKLLLEMDANPNVADSKGHSPLYHATRLKHCECMTLLLEAGVLCDWPTLMQYIALKSWRKCLKILLETDEKARLSGERDEIDMCIRTLVSGSGDVNARDSSGYTALMFAAENGHPCCVEALLQCGAQPDIRNEEGETALLLAIPHCVYCVKLLLEAQADVEVCHPLIKAAATCTDDTIVRLLIDRGADVNAAYSDGYDSPLMAAVKAGNARFVKVLLDHGADPNAGTKGMVRGLNLTPLTQALEDPICLDVVKALVNAGADVNLTGKYGLQPVFLTLQKGGANALKFLLDKGASINATDLWSATVLKRSISNNLVEHVKVCIDDVTNWKENVSRNSLCESGVVVPDVRVHMEAISQAIVRGDKYAIQLFLRYGAQPAMYPFHASQPHNKVENLDEIFSFLALAIMLNNSDIARFFIANLFLVPSDLKCAYFFHKYSGFDNLRAVYSRPWSLRSLSFLALSSAFGFSDNRVDRVLNSGLSDQLQQKLLFKTLNTGTPVDEWSSISLDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIL6</accession>
    <name>A0ABM0JIL6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NHP2-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094480.1">
        <property type="nucleotide sequence ID" value="XM_005094423.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860489"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="7">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005094480.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14631" checksum="4D286E6E330A325D" modified="2025-10-08" version="1">MASESTGEEVNSRAYPLADQTLTKQILDLVQQASNYKQLKKGANEATKTLNRGLSEFIVLTADAEPIEILLHLPLLCEDKNVPYIFVRSKQALGRACGVSRPVIACSVIQKEGSQLHNQIQTIQRSIERLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJE5</accession>
    <name>A0ABM0JJE5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101863972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095019.2">
        <property type="nucleotide sequence ID" value="XM_005094962.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863972"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095019.2"/>
        </source>
    </evidence>
    <sequence length="828" mass="89904" checksum="3D1CA5EB770162A4" modified="2025-10-08" version="1">MFFYFKMASKRVLYQPAPKENVGHKKTRKPLVQGRLAMDAGVERKSAPHLVQGRVTNIEESLDPTLSPLKSVPVLTEHSSPRPEPPSQCLDLSDADFEASVTSALRQSQPVMVFDASHLGNSPHSREVEVVVAYEDSPARVVCHSPRHLERSGRSSRKGSASSVKKSPVSLSDNSVPHWSVPVDRVPRVGSVSKDINRNLFPGEGSENGSVFNSGIEMETPTKFARSVENEAYISQHSRGIIQEILAQEMGTSNLDAISLHSQGSSPSLRQKLSPMSSSPTASSRRTVPHTSSPLSRTPLSQSNHNSVHHQGQESGRKVVKISNYPQPKFDDDSDTSTDRVPVKDDKEPRVTKTSATAQFEPDNSDSETCSLYEYVSPRVKPVSSSASKQSKTGEKLQNAPVNPPGSVRKKKPVRMVPSRYMQSASQYSKANQTISSSKNSTSSGDNSIPSVKKMQKQKSILGKPPGKPVKQEKGVVMNKQSTRGASSAPLKNNSSKHGGISAAGKENRQVSSAVVEAYGESESPKTLVRDTDRPGGGSHKTSTPTHDQLASLSQSIDASAIQSVSALSLSTWGPGMSMLEEETNGSGAGGPKSGQTAGRRAQSKTAVTSENEPSERGSRNKPLSSQNLDLLYSRYIQGQFLISRVKKLFREQEERVMKQLGGLWQLLEEKREEVCGQERELHRLRTLNLLDQTLGVGRELGSLVTAIPQLDSDFSQLGQALGATRNQLPTRDVYFPAGGEDAVEEYGDKMEQALRDSEQLLSEISSETEEQTLALSQYLSSLSAIDKNTGATAEGLTRCVKDLDSIQALTTRLVSLNLQNLQGQDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJR8</accession>
    <name>A0ABM0JJR8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101849682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005095300.1">
        <property type="nucleotide sequence ID" value="XM_005095243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849682"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF124">
        <property type="entry name" value="CARBONIC ANHYDRASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044967790" description="Carbonic anhydrase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005095300.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18993" checksum="04B1ED4E165DB5A6" modified="2025-10-08" version="1">MLVAISLLMILGACQRAEANATGPINWYQKHQNCGGKMQSPIDISTKNVVHDPFLELFNLTEYEKTSGVIMHLANVGGHTARVLYSGTAVYIRGGSLPDKYQLDQFHFHWAKEDLTGSEHSVDWKHYPLEMHIVHHQAGMGTLQSAAARPHGLAVIAFFFKVCRRYSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJU6</accession>
    <name>A0ABM0JJU6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Legumain isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8 9 10" type="primary">LOC101861199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095352.1">
        <property type="nucleotide sequence ID" value="XM_005095295.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095353.1">
        <property type="nucleotide sequence ID" value="XM_005095296.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095354.1">
        <property type="nucleotide sequence ID" value="XM_005095297.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095355.1">
        <property type="nucleotide sequence ID" value="XM_005095298.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936255.1">
        <property type="nucleotide sequence ID" value="XM_013080801.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824854.1">
        <property type="nucleotide sequence ID" value="XM_035968961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861199"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021091" evidence="2">
        <location>
            <begin position="24"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Legumain prodomain" evidence="3">
        <location>
            <begin position="351"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005095352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005095353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005095354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005095355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012936255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824854.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="51603" checksum="7678474EB941240E" modified="2025-10-08" version="1">MALRHGALSLVLLAVVLVVRVESGKNWALIVAGSKDYYNYFSQAVSCHAYHTMRNNSIPPENIVHMAYDDLAHDPENPVQGNIVNVPEGPNLYPGCKMDYRKKEVTPEVFLKVLTGDKEGVKKLIGREGKVVDSGPDDHVFVTMVDHGGPGVFYFPDFVELHNTDLNNALKQMHRENRYKEMVLYVDSCNSGSMFEGILPKNINIYSTTCANTHESGYMCCWDEFRLSFVGTQYGNAWVYDTDKANLHKKTLYQQYEVMKKACNVSGSVSHPQQYGNLSMNSQVLAQYQSKAEGYQPGVCLNTLEADNTLGSKFTFAGIDLNNPAIDMVPIATVARRLIESRDLSGEKREELKAELRHMMLVKEKAESLTKDLVKAAMSSPRGLTEIDILTGKERVFNSECYKAALGLFSARCPGINMGRYPFARRNLQAFINLCNHQRQTDVMNAIMEVTEKYGICRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLZ9</accession>
    <name>A0ABM0JLZ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ran-binding protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101861275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RANBP9/10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096797.1">
        <property type="nucleotide sequence ID" value="XM_005096740.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861275"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="274"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005096797.1"/>
        </source>
    </evidence>
    <sequence length="653" mass="70688" checksum="4E00C4B02BF0BE70" modified="2025-10-08" version="1">MATGTSSQSDSSGSGDDSTDRLKQLYPALDEDETPLPRSWSPKDKFSFIGLSQNNLRVHYKGVGKTHKDAASVRATHPIPASCGVYYFEVKVISKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGNSFCSTGSGQTYGPTFTSGDTIGCCVNLIDNTCFYTKNGINLGIAFTDLPANLYPTVGLQTPGEVVEANFGQAPFVFDIEDYMKEWRVKTKLTIERFPVSDRRGEFQTALNRIVSTYLVHHGYCSAAEAFCQSTNQPVVENIESIRNRQRIQKLVLAGRMGEAIESTQSLYPKLLEAKPDLLFMLKCRQFVEMVNGTDSEVRGGVSPYGPASHSRSPKSHQSGEGSSRSSPSHSPHAQASIPPTTPQFPQQTQHSFHYNQQQHHRSPGSSSSNSPSRASASGKQHPSPASCPPPSLHQQQHSNSYNSSGGGGGGGGAQANNQTEYAHMEEEAMMNSANSAASGDHMAMNGGPRLIQAEEMDLSDEGDHSSTLSNGNSHLNGNSSHCEDDEDMDVDGPSQRRQMCGGNEAAIEKMLTFGRELKVMSQRLRKEFGKSEANKRALQDAFSLLAYSDPWNSPIGSQLLPVKREPVCAALNSAILECKGLPKQPPLELTIAQAGQCMRLMSKSGIGACAFASVLDYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMD8</accession>
    <name>A0ABM0JMD8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribonuclease-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNase I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097092.1">
        <property type="nucleotide sequence ID" value="XM_005097035.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853850"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016202">
        <property type="entry name" value="DNase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371">
        <property type="entry name" value="DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371:SF31">
        <property type="entry name" value="EXTRACELLULAR NUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000988">
        <property type="entry name" value="DNase_I_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00130">
        <property type="entry name" value="DNASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00476">
        <property type="entry name" value="DNaseIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="5">
        <location>
            <begin position="80"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005097092.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36734" checksum="56E4CA92A8C0CB36" modified="2025-10-08" version="1">MAQGNGVILYSGDLQNPTFKDASLPRHRHPRSFHKDGSKRRFIMAACFIVSLLLITAVIVGPTLAFLTSGSSNRPLKVAAFNIQHFGRSKMSDTTVANHITEILVRYDVILIQEVRDSTGSSLKDLWSRLNKTDDWGFVASAPIGRTTYKEQYVFYYRLKLAHLLSTYQTPDSSDVYEREPFSVEFEYFSVTPGTKKQVVLMALHSRPTDAFDELDHLPTSIKSAASHFKGAGGVVAMGDFNADCNYVSSTKQLQLEIFKDNSEFTSLIPDSADTTSGDSNCAYDRIIVFGHDIRARDAKVYNYQKAMGLSDDATGDISDHYPVEFQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMY5</accession>
    <name>A0ABM0JMY5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysyl oxidase homolog 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101857108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097455.3">
        <property type="nucleotide sequence ID" value="XM_005097398.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857108"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050912">
        <property type="entry name" value="LOX-like_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001695">
        <property type="entry name" value="Lysyl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817:SF4">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01186">
        <property type="entry name" value="Lysyl_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00074">
        <property type="entry name" value="LYSYLOXIDASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005097455.3"/>
        </source>
    </evidence>
    <sequence length="130" mass="14744" checksum="2C749FE2A4FEF0CC" modified="2025-10-08" version="1">MEVFAHYDIMDAEGNRLAEGSKASFCLEDTVCDPGVVPQYNCRGYAEQGLSVNCSDNYMYDIDCQWIDITDIKPGDYTFLLEVNPSLLVAESDFGNNVVSCQLNYNGYFAFLKNCHYESLLEYRKPIKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNY7</accession>
    <name>A0ABM0JNY7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101850562</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098116.2">
        <property type="nucleotide sequence ID" value="XM_005098059.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850562"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08311">
        <property type="entry name" value="Death_p75NR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508:SF1">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="809"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="3">
        <location>
            <begin position="890"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098116.2"/>
        </source>
    </evidence>
    <sequence length="1422" mass="160221" checksum="5B42BD3801A678F2" modified="2025-10-08" version="1">MEVSDYYGCYKKYMGTWSQKVLNKDLVRANKKIIMDFYINSHLDTWQLGEEAFKAQTTVGGLLKNQLDDPWKTLDDLSAVSSYLKRTSALFRTPDFPPSSTVCGHVARMLRDLFANMGQLGYAEELYSDMFDFAISVNQSQFPNSDDLISAFENVLAFFRKLKKEHFPKNCDIFPDAAKRFKEALEVLDMKYLTHPAFASVVVNNLLEPAFKDQKKYSRQWVELVPALLKRPCEDTFIACDTVMRHDKSFKWKEYPEVASEVFDLIAKFFQDKSRSAQWADTDLKMIIRLTKQFLEGLRKSKMLKEYGEKMLFFAIHLVEINRDLLFELSVVVSEKLDVDVKKNKAAVMAAIQRYLEIVKSEDLPWDENRNLLDALKNIVQSVTEPVKDAKTFSVDEIGVFVSVAAICLQHDPLDPHTGGFASTHYLIFNKIMGNISGWLEALNRFDLAAELIPDIVKTFDSQDEAVDMLSSRYLMDFSRQSSGAEAVGPYLGNLIEVYKRNDGSNSMYVMTIAGAIESIYPANPKGFKSYYQEMFTDLIESANQIVVTWLARLFWKVSKTQPELFSEEDLEKLLSKAREDQSNQPILLQMIQELCKRRPSAMIKHIDKIFDESGWQPVLLCWMNDMISTLALHDQSVADKSLTYLLQSAMAHQDKANLLTSLNAIRLIGFKYPDTLKLRRSEVEGLSCVDADGKSIQTTILDMIDGKTPSDLAHQLESQLQEVSGLALRVEDTEEAVTEVHTQLDRQGADLDKVKNDVTEQGQRLDHVEETVDETVAKVEVIDQKTLSHAPYWSRDVSKLLNPESEHDWRLLGSRLGYSNDDIRSWAQQADPCMAMFNEWYATRKTSEATFAILTQLQEMDRMDAAIVVENAMKNAEAVVEDEDFEYASPPPIFISYQWGHQEEVKLLKQHLEMAGYECWLDIGQMGGGDKLFEKIDNGIRAAKVVISCVTEKYAKSPNCNREVNLSVGLNKSLIPLLMEKCVWPPPGSMGPIFSEFLYIRFYQQPGEELDDQRYWPGDKFQELLMQLSTFGLTPDEGKIQPVYRNWWMPKVEEIKIDKSKTRDGGNGSQKQQEEFDKQAAETPDVFISYQWGKQPNIIKLYERLTSLGFTCWLDIKQMGGGDSLYDKIDRGLRGSRVVLSCVTQKYSLSANCRREVSLADALKKPLVPLLLEKMTWPPAGPMSMVMTQLLYIDFSQDDAEESTWTGPKFRELEAKIREHVKGAPSDFSGGSSSSDQVNDQVAAIVTTHPKGSRTSTSSKSSVKMTTFEVSFPDSGSSSKAANSNEGSQKNTGSENTSESSLDSSHSRAQVKTKAVLELGKPVRKKSSLQSPNPDSGAVDSSNDLSIDTVPSAKSRSAANETNPEEKRRRISTMKDPLQETLANPQPKPSPQTGDGGQGGKPSKTKAAAVGKRTSKACVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQA6</accession>
    <name>A0ABM0JQA6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101861731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099022.2">
        <property type="nucleotide sequence ID" value="XM_005098965.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861731"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031946">
        <property type="entry name" value="KIAA1045_Zf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16744">
        <property type="entry name" value="zf-RING_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KIAA1045 RING finger" evidence="2">
        <location>
            <begin position="166"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099022.2"/>
        </source>
    </evidence>
    <sequence length="633" mass="70295" checksum="D1EE032A29E036F2" modified="2025-10-08" version="1">MGGSSSKQRKCKSSLKYFGEEKTVAESSFSNTATNNNTRTELSSSCTKKKKGKNNVKIKESDKNDKKKSKKKDNRRVQTGSCQNVDTIFIVENSDVEAEEPNSPVYRKKSSCPSCEAKDILMGINRSRSPSAKSLRYSDFNKVTRKTKIYDSDLKSVDIPLYGVPQPTAEETCYVCGVFTGYQLRTCRVCLRAYHDGCLAKVGHGLSEVARTQSTRGHWSCHQCVSLNHLLTQEEVRGVMEAVIDLGISSESISEADYLKYCKDDAKASGKKMTEEREASCSHRFRQMDKANKGQLSWTQFLNMESIRILDNRCSRSLVNLLTQAELQEARTVFQNLDREKKGVAKKSDIHAMFDSDKSRSSTHFPDEAMMYTEEDLSSLVPWGDFLCHRAIYILAERPNWMNAAEHSEEDLLEDVAITPSFESIDDDDDDDYNTCTSELGASASSAGPMSPRYGMSSCYDSSGDNLVDTPDSSAGVLDDDMTSSGADKSEQNLDAGRCPGSKMTRTTGQESTTVERPGYNDGKGLRFSSTEQNRSSLAKQLQNTQQSSSAQGKKEVEQNKPTPQRRSGTVCSPGLLQRRSEVIERRPPPLITADRELKAKSHVALKANRGIQIAPAFGNLVGKMQHSSEWQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR08</accession>
    <name>A0ABM0JR08_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Troponin I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099501.2">
        <property type="nucleotide sequence ID" value="XM_005099444.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853558"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050875">
        <property type="entry name" value="Troponin_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738:SF1">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099501.2"/>
        </source>
    </evidence>
    <sequence length="168" mass="19296" checksum="DC55642063F5B556" modified="2025-10-08" version="1">MQKAAEDLRNEAKAKAAEKEKYINDRVAPLKTDGLGQTELQQLVKDLHARVSSLEEDVYDWEIKIRKQDFEINELTLKVNDTKGKFIKPVLRKVNKTESKLKKLQTKESTDFRGNLKSTGQNKYALDEEEKQNAPEKNPHWRDELKPKEKSEADAEEGASEEPAEVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRR8</accession>
    <name>A0ABM0JRR8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Prostaglandin reductase-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101864528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100048.1">
        <property type="nucleotide sequence ID" value="XM_005099991.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938897.1">
        <property type="nucleotide sequence ID" value="XM_013083443.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864528"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="16"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938897.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="36642" checksum="1DF9E7643CBD5603" modified="2025-10-08" version="1">MALPATAKQVTAIKLGTNFREITEIRKVPVPKPQAGQVLVKTKFVGINASDINLTSGRYNLAIKPPFPAGLEGIGPIVAVGEGVTNLKIGQAVAFLQNGSFAEYVIVPADKAVPVPSSDPGLLSIVLSGLTASISLEQDGNLKAGETVLVTAAAGGTGQFAVQIAKLAGCHVIGTCSSPEKADFLKSIGCDRVINYKKESFEEVITKEYSNKLDVVYECVGKEMFDISVKNLAVKGRLIVIGAISGYENADGLDSTEMISKQPIAALCLRKSASIRGFFLLHYVKEFPRHIATLAKQYAEGKIKVNLDKGENVANGPFKGLEKTVDAVEYMFSRKNIGKVIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSR9</accession>
    <name>A0ABM0JSR9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">cAMP-regulated phosphoprotein 21 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101846657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100656.1">
        <property type="nucleotide sequence ID" value="XM_005100599.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846657"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="255"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="319"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005100656.1"/>
        </source>
    </evidence>
    <sequence length="1103" mass="117273" checksum="F34B2FCD9F288791" modified="2025-10-08" version="1">MGGFKTWEKSGKGAAMSEVERRAAKLSKQSEVDEAEPTIPPDPHNVVTVVTKPAGGVSTPTVLSASSSETSPDEAPAKPPNTRKQTLIRTQALEGTSPPPDSFLSQLHSNGSPTSPETTITAPPLSNGAPSGGLASQRGSGASYEAKEFLRSSHKMAISNDSGRGTFEITDPVAETTLSRASSTDTNSTASTVVLQQAGAIDKEQFYKDVSSTDEDSTYKDDACVVEKENLYKDASGIDLGEFFKQTLMKSPKDKKTLFFLERELQNFVRDESVRTKKLHEMNPYDRMLVHRLAAHMGIEHNVDQTGKSVIVAKTDYTRIPEPSLVDYLREIEHGSHEKKRILLKKPASLDEKQTRGIGKTQLGDTRAKSLEERQQVYIRIRERIFAKPESLDGSQPQTSTPTLLTASYSPSMMQHQGSVDGLRAPSLAQAKTSHLFKSADSATRTTDSRSHGGSRQRGGMTKSNSYAGSVSPHTTLPGPPVPMAAAACPQALVNTAPPTESRAVPESTAYGTPPPLLATSNPGDTTTMTPVVPPERSVNSPQTPQAGCPTSYAYLVSSDYTSIPVGSLIIDPHTMQPHVNADGSMYRFDPSHPPPFMAVSHSPAPVNPATPPAPTMMYPVENNVNALSGQFGRASISGMEVVSEACPVGQMGPTGVPMLPHMMSQVYTGPTQATQFPQGQYLSTSPAPQHAVRIVAINPQGGAAAPVDSQGQTTVPMPAVQAYAPVQLFSAPQPYQHHMVAAGPQEEVLAGAAYGQLAPETMALNGAGPLMHGYSLAQAYPAPGLTAGQFTHHPGPGPQAYAPVVSSTPTTYYAIPPSTPTPPPLLNQPPPMPPVAVTHQHHSHQGAPHHQQQQQQQQQHQQQQQQQQQQQHHHQVPSHGVPAAHHPHHHHHHPHLPQHHQASVPAGGPHIYGLLHNPAAGPTVTFPHPPAPAPSSSPSVKSWATLHPHYRPASPPQPQQQVTINYVGPPPTPPQAGSQLVAVPTAGFPQRTLIQLGTTQNFQGQPYIYHRPFTPLQGGPALRPHLPSLQLTGPTHGPQGQARPKVNGAGGKSKKGSGKKSTAGAAEEESSGATVTLVAPLIPGLTGASTQTYIPPATSNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSX6</accession>
    <name>A0ABM0JSX6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101848978</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101848978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100749.1">
        <property type="nucleotide sequence ID" value="XM_005100692.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848978"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005100749.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36032" checksum="6EC981CD4F451721" modified="2025-10-08" version="1">MASGQRTDFSSQVEAAIINNQADVLENLLQQADVNMCLNNRRDSPLFLAVKLSRRAVVRTLLSSPGCDLGHQNINYYSPLDLALVMVYDNQKEPRQSACWDILELLLEAGAEPACPDAMLYVVRTALKLNDDQFILRLICTLIDCSTSLDMHTLLLVKLHRNQPLYSGSNSDEFLLRASDFTMKLIKAHHKDALSRIISCFPYYFDSHWESREGKESLFIKLVVYVTIFGWKWKDQADLSYMARVSPDLAQWCYQLPRAVPSLTHACRLALSSSPYSRQFIIPSRIPHILLNYLNFSDIDSLLPFKPSFDFSSIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTQ2</accession>
    <name>A0ABM0JTQ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chymotrypsin-like elastase family member 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101276.2">
        <property type="nucleotide sequence ID" value="XM_005101219.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854096"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050850">
        <property type="entry name" value="Peptidase_S1_Elastase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24257:SF17">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24257">
        <property type="entry name" value="CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047396618" evidence="1">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="70"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101276.2"/>
        </source>
    </evidence>
    <sequence length="184" mass="21843" checksum="40C4ACF7F94E62D2" modified="2025-10-08" version="1">MRTLIILAVLFLGSQSQDVDFDNEGETFEHEIYNMTLISIGTGDNGTLDDNENFTDTTRSMSPTVDGNFIVGGRTARRREQPWMVSVQIYYYGYWYHICGGALIQSHKVAVAAHCMWRWRLYYYYYYYGYYRRFRFRVGLGWYDLRLGRANPYSQTIFVKKVDFHPEYRRGRVGKIYYPNDIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTS2</accession>
    <name>A0ABM0JTS2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NF-kappa-B inhibitor-interacting Ras-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101861896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101306.1">
        <property type="nucleotide sequence ID" value="XM_005101249.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861896"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042227">
        <property type="entry name" value="KBRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005101306.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22038" checksum="8F77D073AC646E55" modified="2025-10-08" version="1">MGKTSKILLCGRSGVGKTAVLEQLLYGNHIVEAPTHSTLEDIYTAVIETDRGVKEKVRIFDVGMPEGKDTELPRHYLNFPDGFILVYDVTSFESFKLLDRLKKDMDKHKDKREGHIVVIGNKSELTERREVQFQTAMAWASKEKVRLWEVSVPNRKSLVEPFVWLTSKITQPTGKSNFLPGRKTKSSASGNLDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVE5</accession>
    <name>A0ABM0JVE5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101845112</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005102446.1">
        <property type="nucleotide sequence ID" value="XM_005102389.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005102447.1">
        <property type="nucleotide sequence ID" value="XM_005102390.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845112"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005102446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005102447.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="18518" checksum="69D58B5C4CBC974C" modified="2025-10-08" version="1">MDLSELVRSHPNLVLALCFGAGFSAGLLLKKIPFLSATAVRQNASANAAQGDASVKVSGDYKMILVVRNDLKMGKGKIAAQCSHAAVGAVEKLAYSNMAALRHWQKQGQPKVVVKVEDEAAFFDIVRTAQKEDVNTCLISDAGRTQIAPGSKTVLAVGPGPIPKLDKLTGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVR5</accession>
    <name>A0ABM0JVR5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854102</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102662.1">
        <property type="nucleotide sequence ID" value="XM_005102605.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854102"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038794">
        <property type="entry name" value="LIAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36474">
        <property type="entry name" value="PROTEIN LIAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36474:SF1">
        <property type="entry name" value="PROTEIN LIAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102662.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34277" checksum="A1B4D97F254AE5FA" modified="2025-10-08" version="1">MEPLNSGKLSSRSNKSGSNKIIPSGSVMDPKAKKSKKKKKNRKNSGKPESDVQESSAKLTSDEERGALEVEGVKALDDTEPEETPNPSTTTKLPSLTNVKAAKNRNSPRGEHPSKLLYRPDQAVVNTLAQRISSLNLKHQKQNNNSSSRLTNGRLRQNNAAGGGKMSNGNGKSSRPAKDKTTKSAPAGVKMTATDRSSHSLPKEESSGGVAIDLVASAVINESLRWDNVLEDSEEERERIKVYKINRRKRYLAAAQAKGLGWALNYSVNSAFQISDDLVYDSVSRAGGNAFTTDYSPIRGLRASQGHALVGQTMVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWD8</accession>
    <name>A0ABM0JWD8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Periodic tryptophan protein 2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101853712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103088.1">
        <property type="nucleotide sequence ID" value="XM_005103031.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853712"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="773"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="883"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005103088.1"/>
        </source>
    </evidence>
    <sequence length="929" mass="103131" checksum="5CB6895E52358265" modified="2025-10-08" version="1">MKFAYQFSNLLGSVYRKGNITFTPDGNSVISPVGNRISIFDLKNNKSQTLPVETRVNVTSIAVSPDGRIAILVTEEGEGLLVSLVSQSVLGHYHFHKEVRQVQFSPDGSKFAVVKDTVVQVFYAPGKTREFNPFVLYRTYPGHVDEAVCLDWTSDSRVLCTGSKDRRTRIVATQRLKNLNVYDLGGVRDTVIGAFFALNSMDIYCVARDAYVFVWKCDTKLSDLEPWVEEISKNKEDEDEDDDDADEDTGSKKKSKKKRKIPEAEPEQGKGIIYSGGGKFSFREARKDTGFCEVTTAAFHKASHLLVTGFEDGTFFLHEMPDFNMIHSLSISEQSVNSMAINNSGEWIALACGKLGQLLVWEWQSESYVLKQQGHFNDMTCITYSPDGQNIVTGGGDGKVKVWNSFSGFCFVTFTEHVGEVTGVKVTQNGKSVLSSSMDGTVRAFDLTRYRNYKTLTSPKPDQFSCLAVDGAGEIVCAGGTTEFMIYVWTMKTGRLLQTLAGHEGPISALDFSQSDGVLASGSWDKTVKLWGIYEQAGMRETIDLNSDVLALTFRPDGKEFAVATLNAHVTFWDTVSAQQKGTIEGRHDLGYSRKDADKVSAKTSAEGKAFETLCYSADGHCILAAGRSKNVCIYSVSDQLLMKKFVISCNHSLDGIEEFLDRRKMTEWGSLALVDTGQGDEKGSAISLPGVKKGDHSSRHWKPEVRVYSLQFSPTGRSWVACSTEGLMVYSLDQGVVFDPFELDMDITPASVRRTLGKGEHSAALMLSFRLNEQSLIQEVLEAIPVDSADVIIESLPDTYVDKLLAFMGHMIESSAHIEFYLLWLLPLLTAHGPKLKQRSQSVMSSLRTLQRNLTRKYEDLRKIADHNKYLSQYLQSLSQLKRKKPSGAVAKEVGQDSDEDDDSEDENLKELAWREGSSDSDSSMDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY80</accession>
    <name>A0ABM0JY80_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTPase IMAP family member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101853574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104364.1">
        <property type="nucleotide sequence ID" value="XM_005104307.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853574"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF184">
        <property type="entry name" value="GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="9"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005104364.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43802" checksum="0832995CA23BC8F4" modified="2025-10-08" version="1">MAARQQRQAKEIDIILLGKTGNGKSSTGNAILGRSAFATSEDAESDTIFSQASYASFEDVCVKVVDCPGLCDTRVKRSVAAEKFVNAMGTAVTLCSDGFHALVLVLKFGNRYTEEEAYTVFMLRSVFGPDFIKRFCILVFTHGEQFELQNRVQNTSRSFMEWINKQQGGLKKLVEEVDYRCVLFFNLTKEKQEEQRLRLFSLVDSLGTENYRYTSETFSAAKREQEQLIAKRNAPAMRLKLQKQISLVQQDIDMARTKISGRKNTAGLDQDLQSILLKLSGLKGDIVAMDKGSGVLNTLGLTVVSMETTVKSQMALLKERRDAKEATLNLEKKLRDANDALSRTVGFKKDKKFISALGTVAKILMIPIQAARDAEDAIGEEEDQTADEGFYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1G0</accession>
    <name>A0ABM0K1G0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854436</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106522.1">
        <property type="nucleotide sequence ID" value="XM_005106465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854436"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="65"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106522.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21682" checksum="AB4DEB008D020197" modified="2025-10-08" version="1">MKEAATTLANCCEVQDIRRGSAWVSVTDTPGLYTLVVPTLGRECREWPEGAPNAEVETLTEENSKQGDVVIFTDGSVQRCVKSGGAFSGRVNGVIQREQSGATGITTSSMCMDMKAITEALNWFKTVEYQSAILVTDSMSTLEKVKKHMMYADWQEAIQSSRLTRIVWIFSPGHAGVQGNKRADKLAGQVERLEAPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1S2</accession>
    <name>A0ABM0K1S2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 4">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005106714.1">
        <property type="nucleotide sequence ID" value="XM_005106657.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858436"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="8">
        <location>
            <begin position="45"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="9">
        <location>
            <begin position="410"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="10">
        <location>
            <begin position="553"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="642"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005106714.1"/>
        </source>
    </evidence>
    <sequence length="668" mass="75587" checksum="23887BA2679E3CBD" modified="2025-10-08" version="1">MIEKMATTITITFIIQLVVAVGLLFPGSFQLENKRKFEIDYANNTFLKDGQPFRYISGSFHYSRVHPYYWKDRLMKMRAGGLNTVQGYVPWNVHETKPGEFYWDGFSDLPKFLSLAQESDMLVLLRLGPYICGEWEYGGFPAWLLSKDSNMILRTSDPSYMKWVDKWFTELLTTIKPFLYNNGGPVIMVQIENEYGSYFACDRSYGVMLRDKVTSILGNEVVIYTTDGCNLRDVFCGKVDQVYPSIDFGADLDPSSCFQALRFYQPKGPLINSEYYTGWLDHWGSPHSTRGTTQVSKSLDKILALDANVNMYMFIGGTNFGFWNGANYKPYQPVPTSYDYDAPLTEAGDVTLKYYAIRDIISKYVKLPPIPIPPNTNKTKYGKIPMEFVSTVQDALHVLTPEGPFKAKYPVPMEKINFYSGFILYRSILTEDYKKPVTLNIHSVRDRAMVMVNSVPFGILDREGASSVSIKGLKGQTVDILVENQGRIGFGYGMNFNLKGIISNVTVGDKVVTNWQIYPLHIENINQTVVSRMKSRSSQRQPFSSADSKLTTPSIYVGTVDIASPNQPTDTFLDPRPWGKGQAIVNNFNLGRYWPSRGPQVTLYVPKPVFNSHTSQNQLFLFELERAPCSTASNCSVTFTDVPYLDGPNKPDNKKDLPSLGYTGHNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1X1</accession>
    <name>A0ABM0K1X1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nucleolar and spindle-associated protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101861313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUSAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106813.1">
        <property type="nucleotide sequence ID" value="XM_005106756.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861313"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026756">
        <property type="entry name" value="NuSAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15874">
        <property type="entry name" value="NUCLEOLAR AND SPINDLE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15874:SF1">
        <property type="entry name" value="NUCLEOLAR AND SPINDLE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16006">
        <property type="entry name" value="NUSAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="222"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="474"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005106813.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="70296" checksum="72768CE0580745AB" modified="2025-10-08" version="1">MPTMEPGEDIDLHFETMKYHELQKLAKAAGIKANQKIDKLVKALQEHHAKAESFSSPKAAPQSSQNSDIVTPQTSQAKTATSKKSVDRSGTQSTPGSSKSVSSKCEKQDRKPTSASDKQKSEIENDKMTSRKRRRTFELDEPTLSPCSTPSSENEGKRKETRSSTSTPKTAPMEEEPVNKRSRRNTFDKTPSQDATENRTMFIPGSSGKVMLECEKEIRKCNNSFNEGDPETTSDKQISRKRRRTFELDEPTLGPCSTPCTESEGKRKKLAPLMDTRKAAPVEQPEEKLIRRETFDKNPFLEIKEKNVTTQRSTRSSSSPSTRAIIDSMDANISSAERKAKLLSALDKKVQEKVNSSPSEAVGQQHSQIPRFMAFLTNKKKAEAQKPPTPGNKDWTKIHNKAFAKFDSIDVYLEKKQQRVQQLSNSAKKTAVSKTPQKTFSQAKVAKPVSRPAAQVKPFVPTVTSTKGINFNFNKTPTSGAGKTPSTLKSARKSFTNGGPAKTPKLLNVTSAQKPSDSAKKATPFKFTGLTGKASSLNTTQHSQKKTFDLKASLAKPLTWKPHTGKLQTVDFNKPAFVSATKSSVQKAVIRPSRQAMASKTRPTHAKDVHRAKQLDRRNNQKYIDMMKRRGLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2M0</accession>
    <name>A0ABM0K2M0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101858214</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101858214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107313.1">
        <property type="nucleotide sequence ID" value="XM_005107256.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858214"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005107313.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="22515" checksum="3CC9338B18A49D34" modified="2025-10-08" version="1">MADTLFFKRSQTMYPYWVNMPPTVPRYPASQDMFRREEPDKYTKRDGRQGYQNWTDKWYDWGHPVRRQEELPLVADRHEPLSRPWQYGVHMGVTGEPKWTREGKDWPINQKKYLRSGIPNTENHRARAMRELSFRDEKLYPFSNNMTSTYRRPVYSVFGPMQKEPVFGLTRQRNRHGHMPFEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3A7</accession>
    <name>A0ABM0K3A7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cyclin-D1-binding protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101845719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107772.1">
        <property type="nucleotide sequence ID" value="XM_005107715.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845719"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="7">
        <location>
            <begin position="49"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="8">
        <location>
            <begin position="205"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005107772.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="37844" checksum="D3835773F6E32887" modified="2025-10-08" version="1">MAGNVSDEQENVFKNLEDNISLVSKQIRDGESKREENAEFDKEAYWIRIGAIFKVLSVETTKMSLAFSKRPFPSHKNTQQMAQELEKGMLTLVSAYYSLPVAQGASLRRHLQAAVLQVLDSLAGFVSALSSCLQPDDKHSGRLQWTGGVWEAAGFILLKDNRECALKSLKDTSELVEDAFGEIEQATENDGQAEDFMGEDDGVITNDAVWSEQDKEVVKACTGLVKATKTILKKSKESVRKHSTVDSPEGVRVLDELVDFVRDVSRSVDDFVCGIYAPINYASLKQNGKVLSQLNGQILKFLRDSSLTVAEDEKWLDFLSQANTHNLNKLTQSTLPQSEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3D9</accession>
    <name>A0ABM0K3D9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein disulfide-isomerase TMX3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005107831.2">
        <property type="nucleotide sequence ID" value="XM_005107774.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860361"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005107831.2"/>
        </source>
    </evidence>
    <sequence length="426" mass="48980" checksum="C4C9D3A02085512D" modified="2025-10-08" version="1">MWLVEFYAPWCGHCKKLEPVYREVAQELHKLGSAVRVGKLDCTRYSHVASEFAVRGFPTIMFVHGDRTFTHRGDRTKEDLIEFALRAQGPTVRKLSSIGKLNEALGQHTDTVFFLYIGEDDQYSDFYRKYADVAEAHAIHAYFYSGKKHILDTRKTERFPTLLVFKDNHYYEYFPPEGVVTASSVQQWVNRERYASFPLMSGPGLNEMVNAARYLVILAVDREALKKSGSLSSRLYSMTKDIAFNSRDKFHSEFQFLWMPEVETVNSIAMSFLATPALMVLESERQLYYLAPLPDNLTRPMLQDFLMRVAEGKEPAFGGTGFSMRIRRIFYDLISTVLSIWQASRWLFLLMFGLPTIIISVICYSLCCMETIDDIPDDEDDEDDEDRELYDRQHPPLPAGESDLPSYDEVQAAGGDHKTSEDKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3G3</accession>
    <name>A0ABM0K3G3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.386</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101850673</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005107873.1">
        <property type="nucleotide sequence ID" value="XM_005107816.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850673"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005107873.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="51651" checksum="D41F694C9CD6FD0B" modified="2025-10-08" version="1">MDLTESEGSRSESCAVEHRQEEDAEDRVLFNPPLYHQRYMFAVRHLTCHEVKSVVDMGCSDGSFFKVLAMVPTLEQAALLDVDHALLESKKRVINPELRHFIHRRSVPLTVSLYSGSAGDFDSRLCGLDAVTLIEVIEHLHPDTLEQVTANVFGNMRPKFCIVTTPNSEFNILFGNEDPKQFRHWDHKFEWTRQEFQLWCHEVCVKFGYSVEYSGVGYPFSDPHSLSLGPCSQAAIFSSQHDEKAQAVHRQNLPNTECYTLIATCEFPFRKDERSLEEKIDDQVQYCLNSMISFRRKEVAYGEEITIAVSAVADFSCVKSLCGIETVRESLLRGGYHLSEDKEFVVHLEDESDLSDNGSDDPSSGYHDVCLAETETSAQDSLLTENSGLFATENVFSNDSGCGTQDTWTPNMSSLSKASSSGNQDDWDLEIALDEERLEIAKNSVVGDLSVTDRSSSVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K484</accession>
    <name>A0ABM0K484_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Caseinolytic peptidase B protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101846917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108368.1">
        <property type="nucleotide sequence ID" value="XM_005108311.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846917"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF93">
        <property type="entry name" value="MITOCHONDRIAL DISAGGREGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="313"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="6">
        <location>
            <begin position="511"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005108368.1"/>
        </source>
    </evidence>
    <sequence length="650" mass="72798" checksum="35888DBAFC30804D" modified="2025-10-08" version="1">MAVRALRRSFVVLKTPQIVPRSSCRALHFQHSRSSVKEFGTHRQPKNIAVPRKERKHLIPKYPVRKVASAFAAVSTGIGLAGIGIFGHLLAAVPIALKNGNPSAEDALISACRAGATSEVKRLLTLGVDVNKRHELGWAALHVAAVNKHSEIVKLLLDAGADPNCSDQFSTVAQKAREKQLNGLHVLLTREEEFSDRLSNRANFQDCTPLHYAVLINDKTSVRYLLDAGADPTTENILGHRALEYTRDPSIREMLEASAKRFKEEKEAREAEERRRFPLELRLKENIIGQEAAINTVAAAVRRKENGWYDEDHPLVFLFLGSSGIGKTELAKQVSNYIHKNKKEGFIRIDMSEYQERHEVAKFIGSPPGYVGHDEGGQLTKALTKCPQAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIECKDAIFIMTSNLASEVIAQHAIELRQEASKLSGMRGASKIEDLEEAEKVTISRKFKDEVVRPILKYKFRRDEFLGRINEIVYFLPFSQSELSKLVTKELKFWAKRAKSKHNIKLLWDHQVVDALAEGFDTHYGARSIKYEVERRVVTQLAMAHERQLIEKGSVIKIAVSNSNDLLVSPKSSSKKTVECTSSEGPSIKLQLLQSGTTNSYKDLVFNDENPFSVPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K668</accession>
    <name>A0ABM0K668_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101850993</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005109659.2">
        <property type="nucleotide sequence ID" value="XM_005109602.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850993"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005109659.2"/>
        </source>
    </evidence>
    <sequence length="475" mass="54889" checksum="3FDA9EB170496A5A" modified="2025-10-08" version="1">MASFVFRIWRRMRCRVTSRLCAALCLAAICFLLIVKCRRSFGLKRAASLGQESGEMVSKGRMEILEDDLHGNRTFYPMEGLRQEQRARIQQLRHECEGKQQQLFGLSSAEWAYGRIEVDTRNGYLYCPLLKVGSTFFRRVFYAVREGRKLHNPYEVSIQRALAAKREVLTELLPLTSENSTRFLENSTSIVFVREPFSRLLSGYTDKLFAPNPYFWGEIGKHIVAQFRPGAGSERGRSVCGHDVTFSEFIRYVVRSERTNDKRRDAHFTPTYDQCKPCALNYTVVGKMETFVPDVALTLDLLGHKVSRERLKTWAHHATADAILDSTFSPWGWRAGILKCMSWGEALRRIWRKLQIRGVLLLENSFPWSVGEGLHKGEGFNRAEGQRREPTVKTFTDTVKRLHEQADPEKLRKQKWSVLAEAYSTVGAEDIEALTEIFLPDFRLFQYDPRPDFIYDHESVAQYRGRDVLFNLNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7Q1</accession>
    <name>A0ABM0K7Q1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear transcription factor Y subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110753.1">
        <property type="nucleotide sequence ID" value="XM_005110696.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853651"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110753.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="37664" checksum="9124CEB58F421A31" modified="2025-10-08" version="1">MIVALPPPTCTRTQQLYHVQSHLHNSSISHNSIGRESVYNNKSSSSNSSNSSNSSNNSNSSNSSNSSNSSNSTNNSNSRCSEIFRPDNNQYQRPLLMHVSAMFPNVLTPSSIYQSMLRSPLGLPTTHPGGALSSSSASFLVENLLRERAAGMMARPQHHPGMTSIPGLGLGVGVGVGLGLSAFGAVPTSCGHNNTAAGGGGGQPGHISPHESDHPSPPINLDRIHENAKASMVGMVTTQAVPSGSPPPPAAIRVVSSSSCSSSSSSSAPLNGTPTNPGLSVAPSSGLSSPLGGPQGPCGGSQQPFLKFGMNAILGKDLHRRSPPTATVVKALRPTNSYFVPALISSTIKVLTPASKSGHSRQNLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7U5</accession>
    <name>A0ABM0K7U5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione gamma-glutamylcysteinyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101855984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.3.2.15" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005110845.1">
        <property type="nucleotide sequence ID" value="XM_005110788.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828895.1">
        <property type="nucleotide sequence ID" value="XM_035973002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855984"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040409">
        <property type="entry name" value="PCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007719">
        <property type="entry name" value="PCS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
        <property type="entry name" value="PCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C83" evidence="5">
        <location>
            <begin position="8"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005110845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828895.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58301" checksum="3B3C0018EC860940" modified="2025-10-08" version="1">MQPKAIEKKTMQFYRRQLPIKCIDFASKEGKVIFTEALSGGFMNSFFKLCAQFRTQDEPAYCGLTSLVMALNALEIDPGKIWKGSWRWYHEDMLDCCTPLDVARVKGINMEQFVCLARCNGLNARARIASAILSLDELRQDVLSACSQDDLVFISSYSRKLLEQTGDGHFSPVAGYHKDRDLVLILDTARFKYPPHWIPLQTLWDAMNTVDKDTGKVRGYVLLSRADSHPSSLLFRPSCDFAVDSVQGNVFLRLKGFSQEWFSWMKSPLPKQVSGAEIVSEAVDRVLDLMKRGQIPVKMFCSNLQCTQWGGTNPSASLKCCPSDEKDGDTVSCILHKLLKELSSLETFQYVETSFTTKLAEEKKMALGLLQSDHTVHETEMNCCNDSCCSSSPSVEKRKVAKLSPELLKCSNSLTISPEHMMTLFLLVWPHKGLWEEVKEGQGRPFGTEAEISRETFGDVLVTFLSNDVQGSTGSYIASEIKSVKYKLEEVMKYHGFSQIGCCGSTKQKTCGKSACHTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8S0</accession>
    <name>A0ABM0K8S0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101862229</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111524.2">
        <property type="nucleotide sequence ID" value="XM_005111467.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862229"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056420">
        <property type="entry name" value="GEMI5_RBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052640">
        <property type="entry name" value="Gemin-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23777">
        <property type="entry name" value="GEMI5_RBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="2">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 RBS" evidence="3">
        <location>
            <begin position="307"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="694"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111524.2"/>
        </source>
    </evidence>
    <sequence length="1065" mass="114000" checksum="C9EA14DA5D822C8D" modified="2025-10-08" version="1">MDYHLQLELWRGNVAGAVQIARQRNELSDWIVAMAPQASLELWQEVSGEYAEQLEEDGQYHKAATYLLAAQKVRQTIDLFRRHRLFKEAVSLAKVRLSPMDPVLEDLYMEWGQVLMKDGQIEQAAKCYLAMRQVQEAGMVLTRRQDHASLKTACHMTLIANEQHPQGMLYAFRLFSQYLASGDWSEAHAFIAEHETLKVLLPLLCTHELLVQQLASLCPELTLTQKSSTSDHFFLKEKKEPATGKVGPPEFLLDKSERDPVVPWEAHLIGEHSFPHHVLRAWYRGLDIARLLQELNATYMAIVQMAPPQQGAPDTPTVLVQVSVELTLCLLSLLTAETTSAVLHLLHSLAALHQGGHLKLLQAICRLMLPQGPKYMLKLQQEFNASRVLIAMENNGNVDQAGVEGHNTIKKYLTDVKEDGHISTASPRCRELDCVRAYFYLVVLDYLREDLNLSHSDNDSLDGMPNGPLSGEASSGGSEGGAVSDIGKESGSLTSSEGGATKEKSVLSSSPKSGDSSPGAGGEVKDDVKSAPCAASPGVAGKKSDSSSSTRPKLKCDSQEGVATSGEKVGEKTTSSSLSKSGSKDKEDSDRSHQLGSLSSPTAPKSSSVDPPSVLLPPLATKAVKGSSRSPPSPLSSSPLSPHAAPKASSTSALSSSPTSAAAAAAMPPRSPGSLHGGDPLSVIKGNSPVSENSSKLSATAASSSPSSLSPPLLSLSPNTSSTGTASATSPSVTTRGQISFRNLLRLSKGILWDVQAKREALTETLGYIHRAISQHLLTNRTSVSSEEGPESESSGSSSRKDGGAHGEEDGGSHRPQLSSVPAAATSPVLSGTPDILKGAHVGATGQPGSVTPPSTTTPTSLSPRLEFGGYRGPIRSLSEPMAHSNTPTSPLEGKMESNVIGFQVEKELLGSFTDYLSSSQKSRKILWMDNRGSPEDIDSGPLSPSGSMARDAGGVPVDWDELPVDVKYFQPYVSLTMLKQEQEALSQELKRVPDTSKAPFPSSRASIKKLMEVCLHSPLLSPQERAVYHKQLSDWAVLFSVTSQQKLETDEFFSAVVAKLGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8U0</accession>
    <name>A0ABM0K8U0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101852135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101852135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005111565.1">
        <property type="nucleotide sequence ID" value="XM_005111508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852135"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005111565.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40115" checksum="B1ED2A6D440B341E" modified="2025-10-08" version="1">MPAVANTTTNVLMNNHTFSADLFSFRPSQDIISNEVLYLLEQIIDIGLCLTLSITGILTNGLVIAVFTRQGRNDSVIKSLTAIAWCDLLICVFSFLHRMHGFLHLISPAVAFSWKNISTLTTLSLAVYISEVSSGLAACVAAERCFCVSFPFKAKQFVSPRHTVIVLVFIAVVIFTLFLPYHCTWRLKVSYSAVYGQNVVFLIIDPSAGLLRLQYDLTASVWSVFFFLIMVFSTVIIMIHLKRSTKFRSGSQGPSIKVDNRASATERKVEKMLVTLILVYIGLVYIPRFLHHSCRVLFPGFYAFQKHHNVYYAVNYFFYVFYLSNSVINFFIYMKMNSDFRETFCNHFWPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K987</accession>
    <name>A0ABM0K987_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Girdin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111903.1">
        <property type="nucleotide sequence ID" value="XM_005111846.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855840"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047315199" evidence="2">
        <location>
            <begin position="24"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="417"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111903.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="62039" checksum="59ADE8797C64A099" modified="2025-10-08" version="1">MSCVSLMSFVALVLLLATSVADSANSPQVASRNGVKIEASPNQIYVELTDQLTVNCTCAHEQNSNFSTIVSLILSKTTATNSSTYRELASITAFSDVKVQEKDTMGAHVTSNHMADQFSFICLEWTDPSRQVAGKYRCEAHGMDKGGHFLTAIADTVVEEKVAGTSAILGKVKEMSDGMNELDRKNKEIDSKVNALDMKNKEMNTKMNTMEANDGKVDSKLKETEIKMNATDMKDTEMEAKMKKMEKKINETDILDKEMGGKMKEMERQMNETDINDREMNAKIKKMEANMKETERELNETDIKETEMDATMEEMERAMNATDEKDKERDAKMKEMEREINEMHIKEKVMDATMEKMERAMNATDEKDKERDAKMKEMERKMSEMDVKEKETERKLNDFKKRVDDSISPLLHASTNDRGRHYLLSKKTSVYVFEANRLCQLHGGYLAEVNDWHEFYFLANFVHTHSYDYTYAMLGASDEGHDGRWTFLTSRTGMSTLVWANHEPDGGTTANCLFLGAGMQRMYDGQCHEYSSSWEVRFLCEVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9X8</accession>
    <name>A0ABM0K9X8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112449.1">
        <property type="nucleotide sequence ID" value="XM_005112392.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864276"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="10">
        <location>
            <begin position="225"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="349"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005112449.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="68065" checksum="C445236D076E759C" modified="2025-10-08" version="1">MGVTSEEIADEFDAFGEQIDDDELLKLQGMCKSWSIDANRIVNEWMAFSASRKVNLSVDTLDVFDREWLLKKLQLSQDKTKTPQDKKGKFYTKENISSAFENDVEILGSYATPEEKSQVTQAAKRQLTPEDLNSSKRRQLGLNNKSPMVNGSYSPVAISPAGATPSAKFSSRSNAGDVVSEFGNTSNVKWTGEGHGCKVTHYDPDTELAAKMKYMFHKMSERGGVLNDVVQEMGTVLQNAHGIEDYAHLALPCQEAVTVCGRVCCDSIGKLNKQSVLLEGSRETSAGKCISLDLTDLKQFSLFPGQVIACDGVNITGKKFSVHKIYDSVPMPFPEVTPDLENVGNQLRVMVAAGPYAPSNSLDYSPLSDLIKYVNRDRPDLVVLMGPFVDLKNTLISTGDVEESFDELFTKQMVEIGRATQDLGCKVVVVSSSRDVHHCSNVYPQPPYSISSHLADGSQRPTSELDVLQHLIFVSDPATLRVNGVVLGLTSTDSLMHLSKSELSVGAPGGSDRMSRLAQHILRQRSYYPLYPPSEDVNVDYGMWEAHAQLPVMPHLLLMPSDLKAFIKDVDGCCFVNPGRLTTGLVGGTYVRMVIDVPTLASSSSPSSSSPPSSACRAQIVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB56</accession>
    <name>A0ABM0KB56_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101863079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113366.1">
        <property type="nucleotide sequence ID" value="XM_005113309.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863079"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005113366.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="46962" checksum="8D4B785472CE3897" modified="2025-10-08" version="1">MTFNPEASTLISEWGLVCDKSWYVSVVISVQMVGLAAGALLTGYLSNRFGRKIVLYSWVALCGVANFISVFSTSVVMFGAIRFFIGLSAGGILSLCHVYPMEFVTVKWRAFVGGFPASSTANVVLGVLMFLTKDWRYLHLATALLCLLGFLTIFWMPESMRWLAVQNKTVQANAVGRKICKYNRRPPPLEPLEYITHAEVEVGEKTDGPRIRDLFGRRFVKKTVFGFILFFTLSLIYYSIGFGIKALFGNFYVNFILFSVFSFPAFPFVPLFSNRFGRRKSISAYFCSACVISTALFLLHFIVGLESLGMGETITSLVIVTTVELAWSTMIAFMVELFPTYIRTLGLGVVYTGGRVGGIVSPFLIQGTAGSVYVAYIVIAVCTALCASLALGLPETRYRRLGDKLTGQLTTPLDTLTGQLTAPLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUB1</accession>
    <name>A0ABM0ZUB1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NF-kappa-B essential modulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012934622.1">
        <property type="nucleotide sequence ID" value="XM_013079168.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858005"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032419">
        <property type="entry name" value="CC2-LZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034735">
        <property type="entry name" value="NEMO_ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051301">
        <property type="entry name" value="Optineurin/NFkB_EssMod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31553">
        <property type="entry name" value="NF-KAPPA-B ESSENTIAL MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31553:SF1">
        <property type="entry name" value="NF-KAPPA-B ESSENTIAL MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16516">
        <property type="entry name" value="CC2-LZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18414">
        <property type="entry name" value="zf_C2H2_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51801">
        <property type="entry name" value="ZF_CCHC_NOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC NOA-type" evidence="10">
        <location>
            <begin position="702"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="682"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="185"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="330"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="530"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012934622.1"/>
        </source>
    </evidence>
    <sequence length="734" mass="83369" checksum="5521A7EE61E8B3BC" modified="2025-10-08" version="1">MMASVDARTAAVAGLGERPVVVQQETGLPQEVTEATLSLTDMTLEQARARLQEMQSYNMSLRDNLREHNKVMKEQFEALSDWRKRETGKFEQTKALITALRAENQELQLKVMTLEDKTKDLSSQVQSLEKEKGHLLRQKAFSDQRAINIEKQAEEQGIVGLEASGGDDVSDAVVFVATADKEQMILDLECSVAQKNERIATLRAELLKKEEEVGKFRDSTKQLLKDMESQQKLKEAVEGENRTLQSQILQAEHKLHQHMQSVIQTTKREIQVDQMFGPVSTEMQPALGRGEGGAAGGQDVSENWKDLGQLTFRQGSSEVLDTVEKMAAKMEEERRSKAQVVLQVEQLQAQLKELSVKNNNTEQQLQEARQEVQATAARLGAEYETKLMEVARQSSVQGTRSIQASNTEDLSIMRSQVLTLIKEVDEKQNNLSAAMAAISTKDGRIRELEESNHNLQKDYRTHWQETHSLIQNLRLQLGEQHRAQQENSLIKRQHHQLQMSFNEIVSEYRELVDMVEANKADMHGQSPHNSKELMEELNRLTAQVMAADEAIALRDEQITRLKRAHNTTTNHEEEIQLLKMQAELYKNDFDAERESRTRLAEERDKLAEEMKALHERHRQLELEMDQRQISDIQRRVWAGGQARMATPPTVPHPDYPGRLRTTPPLAQDFRQAGAGGGFYTGMGRMNTPPPNPAPPQGEEEEPQSLRRYDCPACNAVFPDQDSLQLHVGDCLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVD5</accession>
    <name>A0ABM0ZVD5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011168</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935269.1">
        <property type="nucleotide sequence ID" value="XM_013079815.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011168"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012935269.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40655" checksum="F5B0BE301AB40AC3" modified="2025-10-08" version="1">MALSPTFASTRHLQAGTHEVAQNEGGHLSSYSECQKHPGHLPFFSVNDFGVDALGNVPQGFCKEDVVSWVKSWAPLVVKICSLFISEQRPPTWENQSPYPFADIRGQFVNHMGSGCVRVVLGPIEGLCFCYSCSKSGVKKNKYWEIQILTARHVVFDDLEANWCNIVCFDERPDKNGTQIVRSCKVLDADTEKDTCCLLCYTHSSDLAQNLKRLSDTRYEIDLRVAQNVKERCSQLREEDKSRPTFRTIKELRDQRDETDAKIAQLLLDKTTYRLLVFVISHPHGCAKRITVGHHRGREKGCLTYKAATCPGSSGGAVLILGLRVVSEALWRKEWCGRFESAPHSCALETGVGRSAAWLWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVT7</accession>
    <name>A0ABM0ZVT7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear transcription factor Y subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CAAT box DNA-binding protein subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nuclear transcription factor Y subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101849599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935581.1">
        <property type="nucleotide sequence ID" value="XM_013080127.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849599"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012935581.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="26684" checksum="D10953CBACAF8E5D" modified="2025-10-08" version="1">MNDSHDGSDDGPLESTRMSYAAYDVDAENAGLGSPETEDDKGADEPLKEQDRFLPIANVARIMKKAVPQNGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDNYVEPLKLYLQKYRECSKGEKGITGLSAGDGSEQELSDDMLVQSLANGSMLAEQNGQSVIYTTAYPAGQDFDLSVLADSSTTQLLMPIKSIHDETAGIGSTVVVRMPADSSENSSEEALIFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW22</accession>
    <name>A0ABM0ZW22_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935722.1">
        <property type="nucleotide sequence ID" value="XM_013080268.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011255"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487:SF1">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012935722.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27351" checksum="1AC06D8C9626703B" modified="2025-10-08" version="1">MAACRGMFSSVLADGETESFLDWAKLGRLTFVASAQFKFHPEFYDAGTAKRSLSIETRLMHIGRTSGKLAGAMSFHDETSSPVLEGEYQFILVDPETRRADQFPDWWREKFLKHVVKTEKHLIIQSKPVPTDCEIHVHEITVLPSDIDPYLHVNWSSYLKFCLDAYTSWHIQSFGYEEKGDPFRLVHKVCMSFKGDASIGDVLCLKFWKDVLQENQAYHFHISKKAKVIQECTIEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXZ5</accession>
    <name>A0ABM0ZXZ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011476</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936804.1">
        <property type="nucleotide sequence ID" value="XM_013081350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011476"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012936804.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="27381" checksum="B8451A9D10B1B0E3" modified="2025-10-08" version="1">MPGIDCEPIQNDIKIRYKIHYKIHYKIRYKIHYKIHYKICYKIRYKTRYKIRYKIRYKIRYNKIRYKIRYKIRYKIRYNKIRYKIRYKIRYNKTRYKIRYKMHYKIRYKIRYKIRYKIRYNKIRYKIRYKIRYKIRYKIRYKIRYKIRYKIRYNKIRYKIRYKIRYNKIRYKIRYKIRYNIRYKIKRLKMFRQNFVILRMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY79</accession>
    <name>A0ABM0ZY79_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011517</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936961.1">
        <property type="nucleotide sequence ID" value="XM_013081507.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011517"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33244">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33244:SF3">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012936961.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22035" checksum="8AFB779B3BCC65DD" modified="2025-10-08" version="1">MLLSKSDDPYLALMNYRSTPLQQGQSPAELLMDRKIRTRVPIFPEKLVPKGGERQVFRKIDAAFGQRQQQDYDRRHCAKPMSDLSKGQPVWVKTPRDAKATVVDRSRDRSYLLKTDNGLKVRNRHQIRLRTEGDDSNHLVIPRESSMLPHHQPELPAELLESDTTLHDTSTTSDYIMKSGRPVRPLQRLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYB8</accession>
    <name>A0ABM0ZYB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box only protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937042.1">
        <property type="nucleotide sequence ID" value="XM_013081588.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850881"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22089">
        <property type="entry name" value="F-box_FBXO9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF29">
        <property type="entry name" value="F-BOX ONLY PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="212"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="F-box protein Hrt3/FBXO9 C-terminal" evidence="5">
        <location>
            <begin position="273"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012937042.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53876" checksum="4C430E979C993FA9" modified="2025-10-08" version="1">MDSNQPENQTFRQDPAAAADAEVEDEPRVVPLLGEAVENEEINADENVALGEEDGSSPLSSGSNGGPQIVNDQLDMFRQQWQDELQKKPNSRGQSPRASREDSPGGHKSEAAVNVVENQARAYFFQGMTAEDDGMLSEAIYYYKKALQLVPDIESKLGSFLTRSPRDRGRQDSESSMDGSELEEDLLNNFENLNLREHGLCLPQYEQRGTHISSLPVELIMYILRWVVSPELDLRSLEMFSMVCRGFYMCARDETVWKLACEKIWGVNLGSPKKYGASWRRMLIERPHMLFDGCYISRVTYIRQGEQGMDQFYRPFHLVEYYRYVRFFPDGHVLMLVSPEDPLQTLPKLRHRNSKAAGILKGHYKISEFKVTCVLKRVKTAEVATYRYKRHRQAANQNDAEVTYSVEFDVASVGRRSHVQLVWGSYTVRTYYKSTGHETVNNFDLNKRTFPPLNFSRVRSFLSNSQEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A068</accession>
    <name>A0ABM1A068_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ceramide phosphoethanolamine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938157.1">
        <property type="nucleotide sequence ID" value="XM_013082703.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852244"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938157.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42487" checksum="5498212C3242C279" modified="2025-10-08" version="1">MSVVRCPWPEWTAYWTPPPTWPRRLLCENSLCTSVLFKDTRRLWICAAAALLTYFLTMDAILFSHFRSADLSSSTSGSIEKGEIYTPFTHLSVKGLLNDHPSQFFIAPSTEYFDMITHFSSIFSFITPNMISFAHLVCGFISGKFMSSDHLLDRRVGVVLYEYRTWLDAFDGTVHRAQEGLRLKYNSNHKTLGYVVDSTFDTLGGCFLGFSLLFYLIKKNRPDSGGTGHASHGKSHNNGQAQHSLLPMTSAAQAPPLTMRQVVLKAISFGVCLAVAGKCWDQAVEDFSVVFQTPLTDENLKTAQYEFCHSWTTLALFYLWRVFGGQSVLNYTLLAIYLDKIETYLSGFQFVLLGMALFLYLITAVYIHHIRSVLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A072</accession>
    <name>A0ABM1A072_APLCA</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="4" type="primary">LOC101858554</name>
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        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euthyneura</taxon>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Unplaced"/>
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    <dbReference type="PANTHER" id="PTHR24362">
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    </dbReference>
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            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
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            <begin position="285"/>
            <end position="307"/>
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    </feature>
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            <end position="305"/>
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    </feature>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000313" key="4">
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    </evidence>
    <sequence length="361" mass="40852" checksum="3EB6ABDBD096D333" modified="2025-10-08" version="1">MPVLKEAKYRVLNKDALEILDMEQMELLADRGNWEVIVAARVRQPKVKRVLKKFLLFEDDDDTSMMWKRSSFEHELSFLQSLEHHNIVRVLAAFQCPSYLGFAMGYHPTDLSHGLLDVTYSEAESYTSQLTDVMCYLHGQRIIHGDLKLGNVLLDRAGRVKLCDFGHSQVIPEDTDKPDGWGGTNGYQPPELYDSQVHNAFKMDNYSLGILLWALFFGTAPRNNIDYLKEVDNGSFLKPQHKHCLQRLLALSPTHRAYIWEITRILKDEDTSERYVSKGSVCSLSSESSSDSAQANQPSPDNGFSVTERPENAAMWNQFLAPPPPHPQATSCYLLPQTAYPDSGDVPTSLAPTWPPLHQDL</sequence>
</entry>
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        <submittedName>
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            <taxon>Aplysioidea</taxon>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <end position="191"/>
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            <begin position="1"/>
            <end position="18"/>
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            <end position="70"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    <sequence length="343" mass="36694" checksum="D2361C82C2C76B4C" modified="2025-10-08" version="1">MYSPGNSTLTTIISNTTLPQAAQTTTSPKATSPQQTHTTISHKTTSLQPIQTTKSHQTTSPQPIQTTKSNQITTPQTIQTTKSHQATSPQSIQTTKSNQTTTQLPIQTTLTSIATSPKPIQTTKSHQTTTPLPIQTTIGSITTSPKPTQTTTSQKTTSPQPIQTTKSHHNTSQQPALASPSQTATSPAPVHTSQAGLIVTAGINTTTVTPTHSSMTSLATTATTRTTTHAPVVTQPKGVQCYSCSGLMCSFTIPSQIVHCDDRTPYCLNTYIREAHADHASISKGCVSVKTCREKWFQGSSDRSKCVDLTADSTDRKVCHFCCVKDLCNKPTVPLAQHLYSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0M6</accession>
    <name>A0ABM1A0M6_APLCA</name>
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        <submittedName>
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        <name evidence="5" type="primary">LOC101857950</name>
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        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the villin/gelsolin family.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <location>
            <begin position="1579"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1605"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1636"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1699"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1806"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1856"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1890"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1941"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1978"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2006"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2060"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2085"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2181"/>
            <end position="2192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938419.2"/>
        </source>
    </evidence>
    <sequence length="3168" mass="347347" checksum="ADCD44B5D71AC94F" modified="2025-10-08" version="1">MDARRRRKLLERTSDVSTEDSSSWRSRVYQKDVEPSRVERSGSLTSYTGKTSRSSYHEETSTCEGRRGSADVSPRDSTRRRSEDTSSADLAERLAKRRAQRLEEQGKSSSQEKEGSVDSPRTLRDRRRSRDSSALSQDSVENGDHGEDRLSVRRAASRRHEVVESGGSGAEGAGDRRHRCGSRDSVISADSVDSSVGEDQGRRRWSRRRGSDEEAGSIGATVGSEEVEAGRNRRLSSRDSCFQSAESGQSLRSVEGEDRRSSLDVVPDIAAENQNNNSASRAFDSTSDSLSVSSLTSSSVRRRHRRDVIEEREEEQAGGDVPSSSSIVTPAVVNGVNNDVKRTAPGELGGGVSESSSASTRWRDHISLSGSASVDTSSASADTGSARRSSEDGGGPEAANGGQVESFQARLRRLRGAESEDVTSNTEASTTTSRKESSSTPTLAANETCKEVSTNGAHDREEKTASEGVSHPRNVPEATVVGETSEVYATPPATPPGTPPEEGVSARKRKVRKDKSSVRKSALNMSTSEEDDSDPRGPGSLAGDTSHEDGRTRRKPINATRQKFNQAQDGTSSSSSSKPKSDTAGEPVSKLLHRGRTDFSQLLQKFSGSEASASEKSDCENVGLTSSSPVSGIPRRGFVRRQEAKEIISSSDDSESARRTPERTQSLKLTSNRIREDGNRSSESPGRTGIEKSSSFRSDFMSRRLSQRRDEGSDKESTEPAKQTSAEATVKTVASPTSNKPSASESGTLSGVTSEPAHPEKTSSPPTDLTDGAGTWRSGRGSQEAISKAEDYIKRVETTISTARSKRSAEKSKSPSPGIESTSASGRTGASKSSDDTKLRAEEERAGSFINPTEKPVVDESSASDQAISGTGDAKSESEEKSTTTAATTAAASSSHLPSSQSASHVPDALSAVSSSSSSSIKPDTLSLPSVTTTTTSAEERVPSPVSSTSSISPRPGEAASSDHSFTSSSSSSSSTISSTIRRSASLRDNSFRSDSVDKQRKGILKRTSSMSKSDGGSSDVIVDPQLAKILQQRREIQGDVEEEDEEVEEEEEEAACVSPRRRRSRALSAAEEIEETLKYSQLRAVEKGLNPEEDEGLKRRSVADRIFSMQAKIEEEKHSAAITPRSRSGISTPKSKPRSGLATPTQRSVEEVTPQRSPNFPLSPSRTLSSSSNGSSAPVTAGVNNSSNGNSNNGGVPMGQRSEQDSSAVSGPQLMERLTKIADSSDAYQARRHRFQGRHQKEDWRHLTQPVTYEEIQAADNLETVNAFRALVRKQTSINAFDQLKAQTSDEGKKPQQQQQPLQQGAGKKAEFPQHLAPPPKRQKRGRMMRHRTLPVTAEELNAVPENQELALDPAWTKTGEGGLRDSKADSGILSGSEADGFLDGQQAESLRNLTLEMDLWENDPARMSVAAKSAMFKGMEEKTKAERDKEKSASGAKRYINRKKRERSQTMPITEEEVKTASEMEAAATTATGNQTVRVGPVPEIVNRSRSNSIAEEGEKEALDDELTKLTLSEKVKLFSQPKKAEKPAKVEAPAPRRRNRKHTSRFNTQPVTSEEVEKAAAFSRISPLAMSMVKPPDPEMLKGLPLKDQRELMAQHAEACLSQASSRSQSRSGSVTSLSQPPSRRASISGENAEGKDKELDEEDKKSILKDKSASTKDLHDVRSILKNEPSKARSEPEVHSILKPSGDSPELAPDTTSGSSASNNSISASTTSSSSSSSSAPKGILKKTKSEDLPISENASGDVRSILKHTDSEEEELTQLGKPRSRSNSQPHGILKRDGSPLPPAGSLELGSEIKSILKAPSQENVSDGSTLTVKSAMRRNSVDSDSSTSSAGVLKSALKNRSKNNSECEDSATAITTATSATTEASAASELTPRKERDDDDDDNSTTSGVVVETTTTTTEVVSVVQTENNNNNNNNNNNSCVNVSRQTVTSSTTTCDQLETTTRGATSHSMGGAEASGQDTLKVPDAGDDKSGASASEGESSSGEILDGTPRSTRLKRRSRFSDKNKASERYKTQPPEISEVVAGDQSAKRKFKYEGRHKTQPITPTEMKEAEATTTPSTNLTRTPGGSIADRLNQLKTSGEEEWRKRVRKDDPAPMPDAVVKLREKPGSAANRPSSIADRLSELEVSKMTWKDRVEETDVKQFTVAGKLSNNATESPLVNKLRSRPKKEGDPSSKETTPVTSPVTPTKEFISKIPIPTEIISDPTVVIQTESTKVTMVKKVTRGVAGGGDEEEKKEAVKVEVPLIGEELDTFFAVKSIDEIKDKVDMEIDDFNNIFVESEEILSTVRKVRPSRRKKASSINPLKTLSKKVEIQTEYTQVTRGVAEKEFKRMKKEKLSKDAGFAQEALAGLASKENFKQVELRRSDSGSSVHGQRLDPFNEVMLLHVKGRRMVQTRLVEPHTRSLNGGDCFILVTMDKIILWEGQFANVIEKAKAADLASYILQKRDMGCKKATEVSTVLQAKDHLGAGKLFYQALEGDKQCQACGPDAEDELYENSVVRSNMVYRLEGNALKPYTEYWGAVPRHEMLKRNEVIVFDFGTEFYVWQGKQVTMEQRKLGLKLARKLYDKGYDYTESAINPFSPLRTEEDGGVPLKAAVRPKWSVFGKVNQNMETVVFREKFADWPDSSRIIGCRGHASASEAASKDLLELKPFDASQMIPLSTAPVTLKLEGDNLGRGLKWTEDMQGFIKQKDIITLDVAVWHVLEYDHSKMPRSSHGQFHDGDTYVVRWQYMIANANLRSLKGSAARNSLTGRERCAYFFWQGNNSTINEKGASALMTVELDEERGPQVRVLEGKEPPCFLNLFEGKMVLHIGKREEPSTNTQGPWRLYCLRGDYENEVYLLEIPVCLEHLRSRSSLVLINVKTGMVYIWHGAKSPSHVRQVCRKTVDRIAEHRPPELGFHDDATVLITEMDEGEEKPEVWVALDGRDRKLYHSLLTDPLPYRDTLRLFHMSSVNLVFEVHEQLNPARVPDLVTPFPFLQSDLYKTSQPALYLVDNHHEVYLWQGWWPVGSHEDENVHTGSATARFNMDRRCAMETTLHYCKEKNPSDPPKAFLVCAGLEPKCFTSLFPYWHVDTIVRDIALEEGREESYKESVETVLHRLTQTRYTLAELQERPLPDGVDPLKLEAYLHDEEFEEILEMNREEFYSQPSWKQKQMKIQMGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3N3</accession>
    <name>A0ABM1A3N3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exportin-7 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101853269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940174.1">
        <property type="nucleotide sequence ID" value="XM_013084720.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853269"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057947">
        <property type="entry name" value="TPR_XPO7/RBP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25795">
        <property type="entry name" value="TPR_XPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012940174.1"/>
        </source>
    </evidence>
    <sequence length="1093" mass="123860" checksum="95C14FA0B26C379B" modified="2025-10-08" version="1">MADEQELLQLENLCKQLYETADGNIRAEAEKALVSFANSPDCLNKCQLLLERGNSAYAQLLAATTLTKMVYRPNVTLPLEQRVDIRNYVLNYLATRPKLTHYVSQALVQLFARITKYGWFDVNKEEFVFRNVVNDVGKFIQSGSTHHVMIGVQLLSQLVCEMNQVSESEASRSLTKHRKIASSFRDTQLFEIFQLACSLLRSAAGSIKSLDLNDNNQHSLLSYSLRLAHNCLTFDFIGTSTDESSDDLCTVQIPTSWRSAFLDVSTLELFFDLYSGLPSSLSPLALSCLVQIASVRRSLFNNTERAKFINHLVVGVRGILERPQGLSDPNNYHEFCRLLARLKSNYQLGELVKVDNYPEAIKLIAEFTITSLRMWQFAPNSVHYLLSLWQRMVASVPYVKATEPHMLETYTPEVTKAYITSRLESVHVVVRDQIEDPLDDHGMVAQQLEQLSTIGRCEYEKTCSLLVQLFDESAQRYQEMISSGPAVELAVEEGRLTWLVYIIGSVIGGRVSFASTDEHDAMDGELVCRVLQLMNLTDSRLAQGGCEKLDLAILSFFEQFRKIYVGDQVQKTSKVYRRLSEVLGLSDESMVLSVFIGKIITNLKYWGRSESIISKTLQLLSDLSVGYSSVRKLVKLEAVQFLLNNHTSEHFPFLGINSGNGAPSDMRCRTTFYTALGRLLLVDLGEDEERFYRFMMPLTAHFESVGGLLANANVSINMEEAKRSLIGLARDLRGITFAFSNKTSYMMLFEWIYPSYTPVLQRAVELWYHDPCVTTPVLKLFTELAQNRSQRLQFDVSSPNGILLFREISKMIVCYGSRILTIGDIPKDRIYPMKLKGISVCFSMLKAALCGNYVNFGVFRLYGDSALDDVLAMFVKLLLSVPQSDLLDYPKLSQNYYGLLECLAQDHMTFISNLEPQVFLYLLSSISEGLTALDTMVCTGCCATLDNIITYLFRRLVNKKKKNPNQVPDSEAFLCILELHPEILQQMLSTVLNIIMFEDCRNQWSMSRPLLGLILLNEEYFNKLRSNIISSQPVEKQEAMANCFQNLMDGVERSLLAKNRDRFTQNLSVFRRDINDSMKAPSNSPSSDMMNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3R3</accession>
    <name>A0ABM1A3R3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101855227</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940223.1">
        <property type="nucleotide sequence ID" value="XM_013084769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855227"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045390370" evidence="2">
        <location>
            <begin position="20"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940223.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="45779" checksum="DE954796FD2F14DE" modified="2025-10-08" version="1">MEKLFLSLCLAILSLQVSAQDDGAAEVHFLDNSARHLQVGAQNVEFTCHLNQPVTYVLSDTVDTVLSKEWNGNTSEVHLFSNIKPDEANPNFYKMTYVTVEEGKAINFVLTILEVRHEDDGKLVCKTGTDPVSKDSVDIIVYRGLEKVHLQFGSFPAIMADASDETGERDFGQAMDAGVYPVICVAEGSNPGAVDVKLYLKGEEVPADAEVVVEPMSGNVRKFKSTIETTMTIDSSHTGHNVECIARAPGPNGNSIIVKAPIAVNVYDPVITCDDGEAYPGKRYVTISCSVDHTDIDVDGYYYRIGDTGVLIHEGDDKEVEGKVMMVKKETESPTKSKVVLELYEAADWHFSTDFVLVVESGGGHLTEEKVNLKKIEGKETDNGSSSPGDNGTDGPEDSSAMMAASVVTLVLSLAATLFARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A652</accession>
    <name>A0ABM1A652_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arylsulfatase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101847280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941568.1">
        <property type="nucleotide sequence ID" value="XM_013086114.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847280"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045035887" evidence="7">
        <location>
            <begin position="20"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012941568.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56186" checksum="2D1DE873C6DCE84A" modified="2025-10-08" version="1">MMKLWLPLLFAVWLSAVCGRDNNQKRPNIIFVLADDYGFNDIGYHGSQIFTPNLDKLASDGVKLENYYVQPICTPTRSQLMSGRYQIHTGLQHAIIWPEQPNGLPLDSPTMADKMKEAGYATHMVGKWHLGFYKDEYLPWNRGFDSYFGYLTGSENYNNHKRTFMDGKWYLDLCDQDGPAHNESGHYSGHLFTEKAIDVVQAHDPSKPLFMYLAYQSVHSPLQVPKPYERKYKHIKDRNRRKYAGMVSVLDEGVGNLTQALKDKGLWDNTILVFSTDNGGQVYEGGNNFPLRGWKASLWEGGFHGVGFVSGGRLPVSGVVNRELIHVSDWFPTLVGLAQGSLNGTKPLDGVDQWDTISQGAPSKRTVLLHNIDPLHPRVGVPLYNDTFDTTVRAAVRVGHMKLITGNPSNGSWVPPPGESQALKFVSDRRTSPGKNVWLFNITADPTEHHDLSDQMPDMVRTLLGYLQRFNETAVPVRYPPYDPRSNPALRGGVWGPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6L5</accession>
    <name>A0ABM1A6L5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat-containing protein 97 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941829.1">
        <property type="nucleotide sequence ID" value="XM_013086375.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852565"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="961"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1414"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1187"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941829.1"/>
        </source>
    </evidence>
    <sequence length="1636" mass="184863" checksum="D7588B1A69993585" modified="2025-10-08" version="1">MLKLNNLLHSIRPSDDSPDTDRKDDNLKKKRNNTEKTELEILVQRKQNEVRTKAAHHWAILRASVCSAKEAVQAAEAKDVVITHGIHRDRKLNHQQHLTHVIYISEHKEYLTCDGQYFRFFHEDGRKKDVIDAEEGMNRVVYANQTNQFVGWVHGQEDVFLLSRTFVIRSQSKAVGRILLGTYNHNTGELITVGPHFITCWAFRYGARHLIARKTTKTNFGERKMFKMMVLEETASRTQRMFFAQGNGVVVYNIFSGLEVDHKKELHAQPVTALTFFNPLKYVITGAKDGCIKIWDSSWKVKMVFVGHNDAINFLKIYPHGPAFISASLDCTIRVWNMDTCDEVDKTAISEPIEGMGTEMNYNIFYTYAGKHVDLWKLQHLFHIHTNIGYRVNNIKVTTHPSYPPRAVLLCRDSSVRIICPTNGEVLTTLLLQPSDGLIDAAYAVAENTMFTVLGSGDIIKCMTDQNPCNITARWACNNPREMCNYLLVYEYVVDPTASNDIWAMMKRTVQTRSIQAVGSQSSNKNRTLLLGGRKDGYICVFDWHTGEVTFKADAHGSKGVLNMIANSKSDQLISAGMDNIIKVWRLYPFAQEALAPLMSFYCAHTPSFMTTIKSSLGVAFQDPGTATFSVVLYSLPEKTFASDNPGLEGGFHDRSDHKPDDDHMDLITGLTSCPRMKLYASCGMDGTIRVWNAQNVLIRVLKINTIPHSIAFCSPEGDLLVGISNHLFHISHKKYLPQFYIRKQVCMKFPSKKDESPLEFDENRLNEMDKNDVKRLKNSHASFKFEHFVDILSAEEEEEVMRDKKMKEEAFMMLENRESELVQIRDGALISKHKPKSTKRTQNRAFREYMKMYYNKEREKLPPDPDEDALQKKLVGETKTQEEGEDKYRPETAPYGFFSELSEKYLYEDGDASPLHPSYPITPCGFLPNSVLLKIMYPPPQPKAPSREATPYKPPELTAQQLGEIDSLHSKKGSRRGSELTQDAGFSRAVTFAADDHLSRVLEIDLSDDEELAKTPDETDMEPAVPFEFDESMRPVMDSASGGAPTSGAATIVTPARSSALTVRTFSDLPDSRFTTPKTPMKSRLSRKKTSFLEDEEDDDEDDMFSRGPGLSEKSTSLMSKFQEIMDKEASDVHKIDKATETVQEDIEEKVTPTPTPSEPIKRPVALPAKPIQKLVSRPKPKARTPTPPRSPTPPPPPTPLPNFIKQFVGTEWFDKYFPNCNENTMPKPWTSDTFVNMIVKLLRIAEWLHKVSVTDAILLVHTEEGLSDSVVIQAVKTLASVLNHHSTPPTCSVKEQKDFIMSALRALASFAVKDKDVIAEMMVQFLDGDRDIRASVLEVMTNLGLADPHRQFQKELDSWDIWSLDEKNHREELHKMCNQWLDRWMTSYKLRIKDTVDKLNMGHSLHGRLSHRGSVLGAGSSRRSSMMPGDDTLTTLPDGGSTLKLPTTARSGRVSAMSHGSVTVTLEQLQGSSIMESVNYIDSINYFCEMMTEKELEALRRGEVMRRQKGETVVQAKNTVLVLPKIAHKPALVRLGEMHTSKCRPERETVLHTDFRMPVITNRGRHPAPGDLNGFVPSINLPMKPVYLNPFPSAIDALHPRFSQPILITLKSAQKYFIPSQSYVPLEEHVAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6R8</accession>
    <name>A0ABM1A6R8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Solute carrier organic anion transporter family member 2B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941923.2">
        <property type="nucleotide sequence ID" value="XM_013086469.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854190"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF157">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012941923.2"/>
        </source>
    </evidence>
    <sequence length="604" mass="66360" checksum="45C3C3F998DCDB51" modified="2025-10-08" version="1">MNRVCSSQMDVITYRTLLVMLTVKGVTDSFHSAALPSVYIDDNVLDKSRVSIFIGIQTLMMQLASPLGKQINGALTEVPTDLKDTLMTSKDQRFVGAWWLSYLIFGIGTASVSALIMLMPRSLVSSRRQWEALQRAKEDFKYKGRGEGGANAHGNAHTEGSVGDAIRKVSVVIQPEKEKVNTIQGKLDSHTHNATPRPHVSIPFKRTFSWEPDPLSVERKSSLAMAKQDTGTERQSDLSGPPSPVTKTEDSSTYKDTSFSSVSDSESVESGQFPGQNPSCWGMLKDLPQALYRTCRRPVFALLLLDLVITSIPTSGTGAFRSMYKAKEFNIPMVEVSLATAITEAVATVSGTFLSSILLTRVTSQLGYVWLMFASYLLATVISPLYLVFGCDNEPVYGSDFELRGAPENATDYGCGCLTAGQLISCGVDGRNYLSPCFAGCSGVDGKTFTGCHLLENSTFGDTVSPGLCPTSCHDNFIVYVLLHGVQTFVQNMSLMPKNMLILRLVDPQDRGFAKGLFLFSHVILGIPSPNLFGHVIDSTCLIWDGNYCSLYDRDSMRYLFAGIDMGTHILVQLTIILMIFVLKVQQKRAKRKFLVTENPKEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6U3</accession>
    <name>A0ABM1A6U3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Unconventional myosin-Ib</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106012725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941963.2">
        <property type="nucleotide sequence ID" value="XM_013086509.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012725"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051724">
        <property type="entry name" value="Actin_motor_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049">
        <property type="entry name" value="AGAP003327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049:SF5">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 5" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046176672" evidence="7">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="83"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012941963.2"/>
        </source>
    </evidence>
    <sequence length="104" mass="11546" checksum="52AB73E8233D9FB2" modified="2025-10-08" version="1">MIMPVMMGVFILSIFPSCPQTYIGNVVVSVNPYEKLPLYTHGVIEEYRSRNIYELPPHIYAITDDAYRSMRDKNMDQCIIISGESGAGKTGEPSAHSTTAANCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7H8</accession>
    <name>A0ABM1A7H8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101861151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942337.1">
        <property type="nucleotide sequence ID" value="XM_013086883.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861151"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029779">
        <property type="entry name" value="Rmp24-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15719">
        <property type="entry name" value="Rmp24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942337.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28502" checksum="BE6FCD76DF4E845C" modified="2025-10-08" version="1">MALELKESVSAKFVPKHLLKVKGNDKLQSYFRFLIEHNYRRGINKVDYGRCAACYRSLTIHDHPRLSPAQKKTKKLQKLLAKADKRKLSKFQDNAVKKFLKSSSHLIAKCPSCGHVNRQSIVTNEQKFHIKDMLAHEVAQESMVVPDATESSKKKKKKKKRKTEQSESYGSLKDSLPPSHSADIKKTLFSSNAQGNAVHNSVKNPAPKTLKRPLQSQSQPKGKKLLKQKELQAMLSGSGKPGNSTSLKDFLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7K1</accession>
    <name>A0ABM1A7K1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Agrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101861977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942373.1">
        <property type="nucleotide sequence ID" value="XM_013086919.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861977"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046765755" evidence="5">
        <location>
            <begin position="17"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="194"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012942373.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="25711" checksum="53284F8C83405630" modified="2025-10-08" version="1">MFHLIILSVLLAVSRGQQITPGYSAVCTIVDGLNCAGTNYKPVCGTDNVTYKTECDFAKAHCKDVKLSVQNEGTCANPVTPSPATTPTQVTTPMASVTSPAPASTVPTSQATPPTTTTLPTTAADTTPKPTLSLLCQSLMIQQCPPDNSPVCGSDAVSYSSLCEYTKARCLNPSLTVLNSGACVGVTTTTPAPSVNDIICRAINIHTCFDDGLVLCGSDSITYGNSCEFEKAKCRDESLSLTKVGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A814</accession>
    <name>A0ABM1A814_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein 5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942607.1">
        <property type="nucleotide sequence ID" value="XM_013087153.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848993"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF722">
        <property type="entry name" value="NOVEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="165"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012942607.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="61019" checksum="7584A053EE99B81F" modified="2025-10-08" version="1">MASTVSLENLIRKLRKKLRQIENLERLNRPLLEEEIIKVQSKFALRDELKANLEALHQLEKVTEADGEESEENDDFPAAEEDVDVEDDGEYNENSVAVGAEDPSDRGDAEVSSLPSLPSLPSGKVEVSSGKPDEVVVSGSKKGEEAKAKPAKLSLARAPCRVTSLDGHSDLVTSLAVVGGKVISASRDTTLRCWDIATGKEEKIFGGHTETVTCVIVLDKLFSRSVADTSLSSEDHLIVSGSFDSSYKLWSLNSGQMVKSVYTFNPVTCIHFSEAQAMLITGSDGGKLELWDLASGSNLWSNIVHRGSVTGVKVVEKTVFSSSADGVLKVHHVADDRKLSCVFESENLKSASGRQMNVRHVRCLEYGPKGLFYGDDSRNIKIVDWRKGIANKVPNHGSSFTSIDAICCHDDYLVSSSYDLDNGLGYINVRSSRTLEYLATIDDRETERIVCLAISKLPSGNFYVVSGGMELKVWEVGNKGGQWRTTSLIEDADFVKLLHKGSLSRTAIDSETDVSDEEEDDDDEDDDGDDASVEESDEDPEKKESGQAASWMSWCAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A826</accession>
    <name>A0ABM1A826_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101854895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012942626.1">
        <property type="nucleotide sequence ID" value="XM_013087172.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854895"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="29"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012942626.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="56819" checksum="F2FAF458ECC40DB1" modified="2025-10-08" version="1">MALAGDEKDENNEGAEGPEIEATPLLASSRLGLAIIGFLGFINVYAVRVNLSVAIVCMVNQTAIRSLTAGDNGTDSGSDECAAVSSDNGTSSDLAEMGSLEWDKTTQGTILGSFFWGYLFGQVPAGWFATKFGGKWVYGITMLIAAVATVFTPLLAEAHYIALIIVRVILGAVTGMTFPAMHAIWGNWAPPLERTKLMTFTYAGAQVGIVIGFPLSGFLCKYGFAGGWPSIFYVTGAFSLIWAVAWILLVSDSPSTHKRISDAEREYILSSLQSGSVTENKRDIRVPWLKIMTSLPVYAIIIANVASDWGAYTLLTNIPTYISEVLKFDIAANGLVSALPYIAFWIVINLGGWVADFVRDRKLLTTGVTRKAFNAFGKILPAIMLISLGYVDCSQPTVAIALLVLAVSLTGTQYSGFLVNHVDIAPAFAGILFGISNSIAAVTGFISPVIVGVITEERQTRAEWQIVFYVAAAIYIFGAVFYIIFASGELQPWARVETSGTTRAANHELAVNSEGENLKMLQEGEATKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A995</accession>
    <name>A0ABM1A995_APLCA</name>
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        <submittedName>
            <fullName evidence="3">Myophilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943262.1">
        <property type="nucleotide sequence ID" value="XM_013087808.2"/>
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    <dbReference type="GeneID" id="106013066"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Calponin-like domain"/>
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    </dbReference>
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        <property type="entry name" value="Calponin-like"/>
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        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
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        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
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        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
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        <property type="entry name" value="Calponin"/>
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    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
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    </dbReference>
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        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943262.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12546" checksum="8704B46FC0DBDEE0" modified="2025-10-08" version="1">ERARIELFVYKCQEFGVPEALTFQTDSLYEKTNLPQVCSAIRNLGIEAESRPSYTGSRMWPKKSEANRRTFTEEQLRMGESVINLQMGTNKFANQAGMNFGKKRMITKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9D8</accession>
    <name>A0ABM1A9D8_APLCA</name>
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        <submittedName>
            <fullName evidence="6">Calmodulin-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101862754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysiidae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943337.1">
        <property type="nucleotide sequence ID" value="XM_013087883.2"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
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        <property type="entry name" value="CALM/Myosin/TropC-like"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012943337.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32373" checksum="6DFDFEC7A42C1E6E" modified="2025-10-08" version="1">MSSKSQQEKEEQAQEEVWREIFNLFDKDGNGKISDEELGHVLRALDLDPTQKELDDAVKELDKDGNGVIEFSDFKSYMNKKKTCSYDERKQEMLRAFRLIDKNNDKFIDARELMGVLTKLGEPLSEEEVKAMIRVADVNKDGKIDYEEFVDFILSPCIGPQRNSFCRRQTSKQSNTSLPQQQRPPPPDGRHESRMSTRDSAGFFYTADVTPQPANVPDRTSSESWVPPAGVYARGSMNNRDSMNNHLALNSEDSRLSAYPPVDDGDISPDMQQFPHTGDTGHSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9X1</accession>
    <name>A0ABM1A9X1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943636.1">
        <property type="nucleotide sequence ID" value="XM_013088182.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862216"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943636.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53086" checksum="1A732D338EEAA44D" modified="2025-10-08" version="1">MTQVEPLTTSPSEDNSTTQNDDVISSAVVGDICRVFGVFFAIFVRVLLVVFSLFTVWLVVAKVGSNLYWLLVLPITLIVVEGIYTVIKRGGQERKWVCWCFLLYLVSVVPPIWLLELDRLDEFNDKYDAAVGGVSIVVSGVSADIHLDSSAVLSVTEQCLVFLLILCRWLLPRGDITRDQLSQLLFVFIGMASDVMELFQLFDEEEVRQDKTLTYVILAVWTFSLFQFSLVLTMSQSPKKPRAIGGVPESRPGDPGKDGNNDNDDRRKTDDDGESRANLCSVLIHTEIWSLIVTISMQDGPFLCVRLYTLLQHDLITYSIIFFTCKNVLVILLLLYRLIVVILKRMEEKNDEENSKVDTAEFGERQDGILRQETIIHNDTAITVESNASGNMAIAESTNLRQDPVLLNTPSDSVEGPDHQRASSWNPKDSRILIHVGGGGRHGSLRKEAPQDQRRRQPSKTRFDQDDMKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAC7</accession>
    <name>A0ABM1AAC7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106013255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_012943900.1">
        <property type="nucleotide sequence ID" value="XM_013088446.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013255"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012943900.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34945" checksum="0F91ADD680485153" modified="2025-10-08" version="1">MIGGPTDERVEGHSSRDSNRQPLTGHRIPDSPSCGVSLECPVPKDTTPKYVRFSLLGSGTKGHQFTLLYPAGEKVREFTVCYAMLFNRYNHHAMLLQSITFNRLMGAGHMYIYNQSVGPMVDAMLRHYTDRGLLTVLPMPKRPANKAWYHGQEITIQDCIYRNRNTSQFVVVVDPDEFIVPLQHKSWGELLSDVLHREAKQNHVHNVGSFTFIHAFLCDRSQKHDDPHWTQLKQNVSITEEEEDFIRRNKVILFLEKHRQKFHSYPRRSKTIYRPEFVREPGIHYPRSFWSNQSQAVVDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAK3</accession>
    <name>A0ABM1AAK3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Troponin C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944021.1">
        <property type="nucleotide sequence ID" value="XM_013088567.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862757"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012944021.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17762" checksum="23F6C3AC59FF5D5F" modified="2025-10-08" version="1">MSSLETEFKITEKQYNDANQTFHLFDKKGDGTISTKDLGQVFKSLALQCDGQKLKDWADEADEEATGFIVWEQFKLIFEAKLREDEDERELKEAFRVLDKSNKGVIDVKDLKWILKSLGDDLTEEEIEDMITETDTDGSGTVDYEEFRNLMVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB21</accession>
    <name>A0ABM1AB21_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013347</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944284.1">
        <property type="nucleotide sequence ID" value="XM_013088830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013347"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944284.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11532" checksum="6EA4B7213F0F7215" modified="2025-10-08" version="1">MKNLALSKLDGFAVNLKAYDSVVIVLLFLSANVTSFFISLNHALAMLAASLVMMYHMDLMPWLGALVATITCVVILAAADPDAFYVLLVHVLFFAVSWWIEVPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB61</accession>
    <name>A0ABM1AB61_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106013369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106013369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944353.1">
        <property type="nucleotide sequence ID" value="XM_013088899.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013369"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012944353.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12936" checksum="2E9E3FAC97217C03" modified="2025-10-08" version="1">QLSILKIDVEEWEWPSLPEALTSGALDDVSQLLVEFHLTIKPQPRQARYLHSLLLLRHLYLAGFRTFYTSRNLHCAFRQIFDGAHKAGCHEVNMIRVKSVKFADLDIFEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABW4</accession>
    <name>A0ABM1ABW4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106013465</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106013465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944747.1">
        <property type="nucleotide sequence ID" value="XM_013089293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013465"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012944747.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19292" checksum="AAFF0EF9A3F1F6E7" modified="2025-10-08" version="1">MSPATCQPVDFPVMTTQQTSTIITAYNYPTLGTGGSSLSAEYVAASRDAIQCVDSTPVHFPLTTEELFLQLDSSTTRCSLQFTTDSPDKTVDLSFVPVLYDASFLNVTEFTLELLDGSDSFINSSDVNQQPFRRFQSSHSSVTLTYNKLEVEEGIPPRIFAWLRARARLPGATFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC42</accession>
    <name>A0ABM1AC42_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arylsulfatase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101845134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944880.1">
        <property type="nucleotide sequence ID" value="XM_013089426.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845134"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012944880.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="53912" checksum="62E316D7A6C7F47D" modified="2025-10-08" version="1">MMPRFVSELQNESFIPGMGKMWSENNNNNNNNNNNGSNNIRKPNIVFVFGDDYGFNDIGYHGSQIATPNLDKLASDGVRLENYYVQPLCTPSRSQMMSGRYQIHTGLQHYAIHSEQPNGLPLDSPTMADKMKEAGYATHMVGKWHLGFYKDEYLPWNRGFDSYFGKGLYNTTQHNATQQHNATQHHPQPLFLYLAYQSVHGPLQVPEEYERRYRHIQDENRRIYAGMVSVMDEGVGNLTQALKDKGLWDNTVLVFSTDNGAHVNVGGNNFPLRGWKGSLWEGGIHGVAFVSGGRVPLKGTVNRELIHVSDWFPTLVGLAQSSLNGTKPLDGVDQWDTISRGTPSKRTVLLHNIDPLQPKHGVPLYNDTFDTTVRAAVRVGHMKLITGEPYNGSWVPPPGSSHKYEPDHRRPHQNVWLFNITADPTEHHDLSDHMPDMVRTLLGYLQRFNQTAVPVRFPPFDKRSNPALHGGVWGPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACF9</accession>
    <name>A0ABM1ACF9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dymeclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101846175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dymeclin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945055.1">
        <property type="nucleotide sequence ID" value="XM_013089601.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846175"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019142">
        <property type="entry name" value="Dymeclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895:SF9">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012945055.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56819" checksum="7F48B40E94465973" modified="2025-10-08" version="1">MYQSRPATQFMLYRQLMTGKCAMHAPTLMKALLWNYINQEKCPAELFRGHSDSSGLIYNATAALASSLWSVVTLGMGNKGKKVDSELSETLLANQSLLFILVLANHCTCDRSVTNPYRQALFSFTDTQGDFETTVGLPSRSAVHFKLDMSKLYQVLSLRLQDDQSTLLLYLLLHQNPHVKAYVLSRTNIDLLVMPLLEVLYQSQERSSHHIYMGLIILLVLTEDSLFNKAVHEITVKNVLWFKERQLSEISLGGLLILVVIRTIQYNMTRMRDKYLHTNCLAALANMSAQFTDLHPFVAQKIINLFSQLCKRHSRLVEQIRQSAMDSQANEHTDERADAEQQDNLQDLSVLEEVLRMVLEIINSTLTAGLQYNPHLVYSLLHQRSQFAAFRGHPTFQDIIQNIDTVIAFFSARLEPLGSNPSPGDVLQTIKDGSLTFKKDKLKKFPELKFQYVEEESPEEFFIPYIWSLVYHSANLYFNPGRILLFSLNSEDGAAGKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADU2</accession>
    <name>A0ABM1ADU2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein kinase NLK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945786.2">
        <property type="nucleotide sequence ID" value="XM_013090332.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858232"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945786.2"/>
        </source>
    </evidence>
    <sequence length="234" mass="26167" checksum="B84B553192D722B4" modified="2025-10-08" version="1">MEPDESVAMTQEVVTQYYRAPEILMGAVHYTSAVDLWSVGCIFAELLSRRILFQASAPVQQLDRITEVLGTPSFEDMPTACQGARDYIRSRPHKPAALNQFYSLSDQATHEAVHLLCRMLVLNPNKRITAADALTHPYLDEGRLRFHSCMCSCCTPGAQGRNFCGDLEPECPLPFDYNFEKSLTSVSRVKDKIYKFIQEQQHRTTSKLPLCLNPQAASLAKIQNARVASGAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADW0</accession>
    <name>A0ABM1ADW0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Protocadherin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC101849104</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945815.1">
        <property type="nucleotide sequence ID" value="XM_013090361.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829341.1">
        <property type="nucleotide sequence ID" value="XM_035973448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849104"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021921" evidence="11">
        <location>
            <begin position="27"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="41"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="149"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="260"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="370"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="477"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="582"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="696"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="912"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="983"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1107"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1184"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1114"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1184"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012945815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035829341.1"/>
        </source>
    </evidence>
    <sequence length="1255" mass="136657" checksum="874F4C3A646D046B" modified="2025-10-08" version="1">MDRCHSFSVISVVALALLSLVMSVQGNDEVNLDYHHREESGSNILVGNTAKDSKLFEKYRDKFQLLEFTPYTEGNRNAQYFNVDTGSGVIRTAKNVDREEICRKEATCIVNLAIGVYMKQPGSVSKVLDTIIQVKIYIDDINDNSPTFPRKVVNLPVSENLEVNHPLTTSVATDNDAEGRNSKITYLLDSYTTDFEVSTVRTTDGFEDLVITIKRALDREERKSYPLTVVATDLGQNPLSGSVLINIQVTDINDNAPKFGQPNYTKNVLENSDMSDPVIIVSASDLDEGENARLTYSLSSQVSQDIRNTFVVESESGKIFARVPLDYEKKKSYQFYVSVSDNGSPPETASAYVAINVIDVNDNAPEIRVNPAPNSSPVVEHGSEGRFLAHIRVSDDDSGVNGEVSCSIDDDHFVLESFNDPARKIFVIKLSRPVDREEAAVRDILITCKDGDIRPMSATATFRVEIEDINDNAPQFVDSTLYGTVMENGDKVTFVMQVVATDADAGENSEVTYTLVSGEYLSLFSINQVDGTISTTTMLDREDRSEYYLVVVAADNGNPQLSTTATVTIKVLDENDNPPKFTKQAFSNSITENLPNGSPAGDVSAYDADAKENGRFVFSIMNDAKSVISADGIFFTIDPDTGLLKSETTFDREQRSVYKFQVKVADPLVPNYYDIANVTVTINDDNDHAPVVIEPPENERTFSCPFNMTIGSIITTFKATDEDDPALVELSYVIHDQGSGDSNKGEPSLFSMDVATGKLRVARQIRPPDVATHALDIVVSDGPGATSQSTHVIINVVVEEGSEEAMRAFGANSGMKTTNIIIAVVIIVATGILAFIIIVVICLIRRADKKRQASQASNAQQAAVDSKLYQAAQWVSTVSVANDQHGPEEIRATLEVPGAEKKKKKEVSFSLDDEVVESPDTSGSLGSVFNPSPNAAQKQQAPGSVGFIVMNGMTSPDYSQHLYDPRSTSTDTQDEHQFMEVTRQAEDRYSDASSGDTGTSDSGRGGSEDESHGHTSSSGDGDVRRFKTVGGSLSSSGVSSSGNNDVSGGHFHPHQSNHYQIQNQHLEEEPEEIPGSPTPMLSEQDRSPQTTPQHCYIRRSFDRLPAARGLGYHPSGSGTIGSSSSARSSPAPHSPSPSPQHYNTQPVPIKHSSARLTLSHNDCEGPYRVKKAEQHQQLLQTFSSPYSATSSGGPASPHGGNSAHHPAWRRAKGLDTSWRSSSMSRDDDDNTTTSGSYTINPDDLRDESYNPDVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE29</accession>
    <name>A0ABM1AE29_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chordin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945927.1">
        <property type="nucleotide sequence ID" value="XM_013090473.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852529"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045717">
        <property type="entry name" value="CHRDL1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46303">
        <property type="entry name" value="VWFC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46303:SF1">
        <property type="entry name" value="VWFC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046689096" evidence="2">
        <location>
            <begin position="24"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="207"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945927.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53574" checksum="CB2EDC9FAA7F206D" modified="2025-10-08" version="1">MQKMTQMLVYKVLIFVMVYRCSGKPSGGPCVLGGEQYNVGETWHPKEFSSTANSCVHCTCLEGGQINCTGVDCPSPECEVPRFIHGQCCPTCDEFDNITPTVRGDEAGSPETDMPGCDFHGDHYEDGDIFPSNKTAYKPKHDNQCVLCGCYRGEVICHLKTCLPSPRCRRVVRVDDDCCLQCEEESSIDEYFMSIGSDNINHTLDDEDCLSATGRRKNGSTWKPVVGEYGEMHCIVCSCLEGQVDCKRLTCPDVTTLTCRHPRPRQDGCCKECPESDRQRDNRKKKRKKSKKGKKKRRCKSGDDSEGKKNCKRRGKKRKTKRKKNKKSSTSRSSTGDIFTPGMRLDDVFHKLCIPPNVDRLVYHIKGGNFDSVVFDNPKDQTIEHIRWTIRKGRIHDTQRNWVLAPEDFRRNVTVADIVGGVKKKDIKRFMRRFAKREQRCKKRCRRKLIERSVKKIKAKTIDLSRSCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF64</accession>
    <name>A0ABM1AF64_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 231</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101846056</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM231 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946498.1">
        <property type="nucleotide sequence ID" value="XM_013091044.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846056"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019306">
        <property type="entry name" value="TMEM231"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605">
        <property type="entry name" value="CHST5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10149">
        <property type="entry name" value="TM231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012946498.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35998" checksum="27E18E42954678B9" modified="2025-10-08" version="1">MAIFEIFSHPELRRYKASVFSKATLMMLVILILTFIPPLLVVYRSYGFWLREATYREQPTVAFKKEFILILDLQSPDSTVAYSTFQQYNQLIQSQLRIPVTKVREEDVNGDGIFDRLNLDIQVPMTGADRVVGAKLLLFFYYKLRRFSQLHMEGVGYVEHSSPLPGASLDVFADLRMRQRQLLGHKGVDARYNTSLVDPTSPYASTYSLATIFRANSERNVTTILQDVQSVWSAGRPADSPFTISARVNYPEEVIVYSPGFWYLIKWGWVQYAAVLLLFLAVFNKVKVFVFQHQVVTTVVESSAAANDGRKDKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF65</accession>
    <name>A0ABM1AF65_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-rich adhesin for platelets</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106014036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946499.1">
        <property type="nucleotide sequence ID" value="XM_013091045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014036"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09538">
        <property type="entry name" value="SAM_DLC1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659:SF7">
        <property type="entry name" value="CROSSVEINLESS C, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659">
        <property type="entry name" value="RHO-TYPE GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="483"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
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        </location>
    </feature>
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            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
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            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
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            <begin position="704"/>
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        </location>
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            <begin position="1003"/>
            <end position="1014"/>
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    </feature>
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            <begin position="1089"/>
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        </location>
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            <begin position="1136"/>
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        <location>
            <begin position="1170"/>
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        </location>
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            <begin position="1269"/>
            <end position="1310"/>
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        <location>
            <begin position="1311"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1354"/>
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        <location>
            <begin position="1399"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1429"/>
            <end position="1448"/>
        </location>
    </feature>
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        <location>
            <begin position="1452"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1666"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946499.1"/>
        </source>
    </evidence>
    <sequence length="1688" mass="180664" checksum="1027239E504C1DE9" modified="2025-10-08" version="1">MSLLPCPHDPRPLLTGPALQHQTTGARNFRRVLPPPQSPSVGGIGGGLVGARRAVVSDSTSDYDNVGPVSRLSCVLEEGKIEEEEEEEEEDEVKEENQKKGEEKLKLKKKAEVIREHGEEKKEENEERKKGEEGENGGNHEIVNGKDNSEENADEQGETINPKSVENVSSAVERPLRKVNDNCPAPQEGVNRESEEEERGEEGKTHRDSAEIVVNGRAALSFKEGAGHVPTHVDTEQSVPRAGRSGSHVQRAPQDGGGESQSVAVSPIVVLGRSEPFSSAATGSLCEEGADAHSLVNSRAQFDSRSHPVSIMGNNNSSRQQHQQKQKKQQQQQKQQQLSSDNPWEKTPIILDTYEEIPAEKVSHHNQKTIARAEEDFSSVRASNGSTLSFQSCSSASDFTRERTTKINDNGSVDEDKEEKDSTTERDDDDSQKEKRGSRADSLDSMTSLSNMCKFVSKRNHVSSSQKIDKVDSFSSCRSHVSQIPVVTDGHRSSTPATGHTPGHTPGHTPGHTPGHTPGHTPGDTPGHTPGRRSPIANSVPALESSHSGDKRASSESGAPVWASHGPRTITHPTVEVSNSPRSPPGDCALSSSRPTSVTYQGRGMATPKTTSDNAPTARGPAKVEEILSPTTTQNTRMCTSVAVATTTPPSPPSPPALSTTTTTTNQTSIVKPGSPTPTPHLVTSSHVHGARDKRVMFSPPATDPHHLNGFPRKDPPEEPVYAEIKKLDSDEPDYAEVQKPKQKSVHRSEASDVTTPAGIPRTCSGLFGAGVPSAGARDQRLLHVHHPPPPAGPPVATSVRDVTHTMGHADSKPSPPLPPRLPPVVLTRSESTGCRGGRFTQDRAPTTKCLTSDTRSYSLDSAPKPAVVPPSAYLQERHSEPREIVASDSYNSRQPLPCRVIREVSHDNAQDDYDSYEDEVTLPSKVLVRCEMKRSTTSVGSFSHAGPLGGASSSKMARSASSNGYDYFSLGRRPPRRLAPQTLRDFRGVGLSLDMLLRTRRQSSLDSGQSPGDSDTDGLSVEDILKSCSDYDVNSDPFYRSRTGSDIASQSPLRYMAMVGVSASHGDDLDHKARAKHARVVTFQSPVQERKGMRARSGDDVRVSPGGHQHTRSDSDDNLVIRNASRSGGILRCGSPSSTSNSKNNSNNSNCNNNNHIMFGGTSSPISPRPGSSLRASSSSPPVSKATHVTPTGTAHFGPRVVQNSPQSPTSQRAQTWKPVAPSSHSTNVICSYDAPKQQLVISSPVKTVAVNTDHSPRAISVERDSDTSSTLPPRGSDSTHTADGANHSTTTTTSNGDRSSTTVRTQLASNSSSFPSPSTRSPTSPPTSLQISRTNSGGGATLSRTQRPKWASPSPSSSSSSSSSSSSSSSSSSSSSSSSTFDSGLHKHFAASRDSAQRGSNIPGNSSPQNFALARSTNTPSPLSPTRPASTSQDSGYHGVSVSSSEADPRSPVSSLSPISSPSRGSSPGPVMASLSVDISADTSSEGRSSPAPKSPNQLAKLEAVEALKWLKAAGFPQYAQMFQDGQFPVELWSVERDHDFLDKDSLQSLFRRLDTLNKYAGMKIDAQSRKKAASEDEEEDDLCALSERWEYQKSVRRWSRKDLHSPTPAPPSAEEADVTEVIDRSASHDSLLADQDSGSQTGDSPLLHPRTAHSSAASGGGVASEETSSRQQQQQQQKQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR99</accession>
    <name>A0ABM1VR99_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transient receptor potential cation channel trpm</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824941.1">
        <property type="nucleotide sequence ID" value="XM_035969048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850877"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1010">
        <property type="entry name" value="TRPM, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032415">
        <property type="entry name" value="TRPM_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037162">
        <property type="entry name" value="TRPM_tetra_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16519">
        <property type="entry name" value="TRPM_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="73"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM tetramerisation" evidence="8">
        <location>
            <begin position="399"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="905"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
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        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
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        <location>
            <begin position="909"/>
            <end position="920"/>
        </location>
    </feature>
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        <location>
            <begin position="943"/>
            <end position="955"/>
        </location>
    </feature>
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        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824941.1"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111992" checksum="35A157089A36B6A0" modified="2025-10-08" version="1">MEPNSPTVPPVKENGIIPPASNGAAANGTPMDTSIFSQMPFRKKKSPLRMGKKVYEFYNAPVTKFWAHAIGYMLFLVLFCYVILERLKPVPTWAELYIIAFIFTMALEKIRQIIASEPVKVWMKLRVYISQLWNILDTLGISMFAAGLVLRCIPSTLRDGQLVYTVDIIFWNIRILEILSVNKYLGPYVKIIGKLLRDMCYFLTILFIAVTSFGLVRQAVHFQNKEGSWHMRLRNVWYYPYWMIYGELFAEEIDPCDDPENNDSLGICKIYAAWLAPFLMFVFLLVANILMVNLLIARFNATFIRNNANSKEIWMFQRYGLILQYEVRPILPPPFILITHIYLAFKYIKRRCKGKRDFYDNGLKLFLSHEDTEKLHDFEEECMEDLYREKDLKFHNSSDERVKIINERVENMSLRLDDMNVKENHLRLTLATLDHRMSRIDEVADSLVHAVRLLTRATRNDDMGSQESLEDAQQFNPPPYSNMEGHPRTLSVSSSEPGDRNQPSPMLVHSKNRIQTDQLSKFTNYARRRQLSGSEFPIEESDQFVGEGQSQSGAQGSSGVSIASLNPADDVRFSIGASDINNSSNTLTTDVKRRSVASVDEDSGSANRPESSEELSHKQKIRNFASQSVRFVEPIVHSIDDRDVGNTPQQPSINVTARLDTGTHTVSQKRDPASHTEGADAGISDGGTPPEEAEANPKPLPPVLQISIPSDPPIVAAPLSSTSSSGKTPRAGGKLAFSGQPLVMPGSIATSTYTPISMPQSSACFTANDADLIPQSAARDLSSMLNPLIGEYTSITDTIDTSCIEDCSPPRSPTSSSAIMFSVAEGYHEVEAKLKERSAADNKQQALKQAEETEHQRMEYLIRHRLRQISQKNAREWAQYLTKDESGSISDIARVVVAELAAEDKKLDESEESEIAEAEDIAVAAGQESSEEGQEMEASGSSHQEVGSGTPGQRQDSSDLEEEATEQTRLLFRDRVRIRISQPSQDTASGDSQSLSKFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSX0</accession>
    <name>A0ABM1VSX0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC101862347</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101862347</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825510.1">
        <property type="nucleotide sequence ID" value="XM_035969617.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825511.1">
        <property type="nucleotide sequence ID" value="XM_035969618.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825512.1">
        <property type="nucleotide sequence ID" value="XM_035969619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862347"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045023426" evidence="1">
        <location>
            <begin position="38"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035825512.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34354" checksum="08F37B26699FE0CF" modified="2025-10-08" version="1">MAMSDARATLRRMMSVFVMRVMMIMMVMMLTLRPVDARCTKTKSGKGYSLTIGMLSAGENDFSAHRIVQKNLMMTGEVKDCFLPPHYLNLAVNETLQIPRKGWTKIQGGIEDALSTQGALDGEIPNLIIGPFYTNLAMMLQRMGIPYLVTDYKGFDWIDMSRVQDTVNWRTVVEIRPPAQAQNLAVVDLFLERKWSSAMMVMPESAADNQECQNLASQMLNHSLSLIPFTVEPRDPEVRTALSELLRNAKMFRQTQVLVCSPRDYRDQLIENILKEVSYIEGDWWRRCYFFVSWVLIGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTT0</accession>
    <name>A0ABM1VTT0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101851350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825822.1">
        <property type="nucleotide sequence ID" value="XM_035969929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851350"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035825822.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="61705" checksum="AD944F981B762EC8" modified="2025-10-08" version="1">RALKKKAANPAVKKPPAPKPKKETPPPPAPEPKPKPKPKKKADPYYEKEIENIPCDGTLKPFEPFNAEADAETLRTATKGIGTDEDALINVLAYRASPQRVEIVNAYKTMFGKELVEDIKGDTSGNFCEALKGLLLGPAEFDAHMLRSAIKGLGTDEDVLIEILCTRSNAQIAEIKQAYQESESCDDTTGDYQRLMLALATGGPPPKATSGKAFVESVKYKTDEQLDEDVKMENEPKQEDPTLVPFEGFNAEQDCEVLRKAMKGFGTDEKAIISVLGHRSMDQRKEIALSYKTMFGKDLGSELSGELSGNFKTLCVEMLLGTAEFDAKQLNKAVKGLGTDETTLVEIICSRTNQQLTDIKAAYKTMYNKELETDIAGDTSGHFKRLLVGCLTANRPEGTEFDRNKAKQDAQALFEAGEKKWGTDESRFHTILVSRSYAQLRATFQEYAKAANKDIEDSIKSEMSGDIKDGMLAVVRVIRHKSAYFAGQLHKAMKGLGTDDDTLVRVVASRCEVDMVQIKEDFQKAYKQTLAMFIVDDTSGDYRKMLLTLIGEESSIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTZ0</accession>
    <name>A0ABM1VTZ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101854086</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099244.1">
        <property type="nucleotide sequence ID" value="XM_005099187.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825882.1">
        <property type="nucleotide sequence ID" value="XM_035969989.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854086"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF73">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="91"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005099244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035825882.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42575" checksum="6DB5B046E56FBC76" modified="2025-10-08" version="1">MLTVVILIQNLRWMVPTTFMIGAAPAYITVWTAWRALSAILPRWVYVKGDDFLFSTYKRNVLFCFETLTGTELMFYGDPESMKELVLGENALYISNHQCTVDWVMASSVALRRGSLGRLRYVLKDGLRYLPLYGFYLGMHGSVFVKRAGRFSKEKAEKQLSRDAKDKKPMWLVIFPEGTRFNPELPNVIEESKQFTQSQGLEPLNTVLYPRIRAVQVCVEQLRNSVESLYDVTLAYSNTFDYDKGQRRPSPTMQDFLMGHSQRVHVHIQRIPISDVPSEPEELKTWLYQRFQEKEKLLNYFYSAPSDKEAKFPGEAITKPLPLTYVLPSFLLWGGAFAVANWFKQSRDLYWKAGSIIGCAGLIWMGIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUH3</accession>
    <name>A0ABM1VUH3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101850725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_035826065.1">
        <property type="nucleotide sequence ID" value="XM_035970172.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850725"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045011137" description="Metalloendopeptidase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="11">
        <location>
            <begin position="86"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="381"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035826065.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="46455" checksum="13B51D92B3C13458" modified="2025-10-08" version="1">MSYITEVKFLWTTSVLLLLVSTSTEMSLDKMIEGAAKNERAIEFLGTDHKDSVIVELDMKYSPEQYAELVALNASSVATRRRRKRNALRDKKYRWTDNVIPFELSSSLKPNAPPVIMEAMQEWSMYTCITFRPAQPTDTNKIRFVDGSGCAAYVGMVPNRHEVVLAEGCLYKGIVLHELGHVLGFHHEQTRPDRDDYVSILYQNIEDEMEYNFHKYNWGVIDSFGVPYDYRSIMHYGSTAFSQNGETTIKTLDPLYQSVIGNRMSLSFRDIKIANKMLNCKPSSCALDDAQCPGEGFPNEFCQCVCPGPTASNPIILCEAEAGSGASTGSTSGTVAKACKDLSPDCPILVRQNACTLAPALMQVHCQASCGFCKGAAVKPCIDEHIHCSTWASLGYCVNPQYLAFMLDKCKRSCALCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX54</accession>
    <name>A0ABM1VX54_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Breast cancer anti-estrogen resistance protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826996.1">
        <property type="nucleotide sequence ID" value="XM_035971103.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848220"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11844">
        <property type="entry name" value="SH3_CAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037362">
        <property type="entry name" value="CAS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654">
        <property type="entry name" value="CAS SCAFFOLDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654:SF18">
        <property type="entry name" value="IP17195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826996.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11222" checksum="9258AB48B4FB1AD7" modified="2025-10-08" version="1">MTQGMFLAKALYDNIAETPDELAFRRGDVLTVLEQEPGGLEGWWLCSVRGKHGIAPGNRLKILSGMSPGEAGSNNGSLNQVGGWLLVCGVAHVLGIVMVQMKNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXL8</accession>
    <name>A0ABM1VXL8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor A domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827161.1">
        <property type="nucleotide sequence ID" value="XM_035971268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478190"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827161.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21076" checksum="31FA2EC71D78EC0C" modified="2025-10-08" version="1">MSVITYNARVRPQFCFNDYQNNAAVKEAISKIRYSTGVTRTDLALQYAREYTFNTSTDCGAREGAAKVVLVVTDGNSTVPGFTIQQAEKLHESGPTVITVGIGAALSRKELFAIASENSLVFRVNDFSLLDVIKNRVVATACMASLISPGYHDLCNAYCRSNMRCQMNVASEVNMCECPPFTTYDPKNIVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VY27</accession>
    <name>A0ABM1VY27_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Sodium-dependent glucose transporter 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC101858801</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104820.1">
        <property type="nucleotide sequence ID" value="XM_005104763.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104821.1">
        <property type="nucleotide sequence ID" value="XM_005104764.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827320.1">
        <property type="nucleotide sequence ID" value="XM_035971427.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858801"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF9">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 7 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005104820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005104821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827320.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="60044" checksum="FE8973B5CA5634AA" modified="2025-10-08" version="1">MDEISPEGEIIKGNRDVQDLDPLKQEDAFSKKKKKRKPLKEQLKDPIYKKKLINSLCISLVFLTLGMCIGMHGPTFLDLQIITNTDVERGAAFFTAGSIGYFIGSVATGAVYNYVSQSLLLFIGSTFLGVVCCITPYCSPYALMIFIRGAGGVACGFVDTTGNANHMQIWGNEGQVLMQLLHFCFALGGTISPLYTEPFLAPKEDEENSSTVSLNMITVTTVGPLNASSSGYGILPPSRNSSQNFNLTSPSVGTERTTHVAYAFLITGILCVASAIPFLVIYVKEKLKEKKKGKTAEETLTQRDLPRPVLVFVLVTVCAFYLVYCSVEDTFASFLMTFLVKQYDFVSKSKGAYITAFYWASFAVSRFLMIFLSKILSPVKLLTLCCSLMVVSFAGFYISATFSAIKALTFFAVLAGFSMSAVFPSGFSWTEQELLRVTGRVSSCILLSACLGTMANPMLLAYLMEEFSNMWFCYLLVNQTVLLCVLFIFLLIFNRCYLNVRYGKLQMTPDITIDVELEINQPLSSENLGKVQNCVDPLDEKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYU7</accession>
    <name>A0ABM1VYU7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478306</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827590.1">
        <property type="nucleotide sequence ID" value="XM_035971697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478306"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827590.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24297" checksum="7C4782AB95DABE6F" modified="2025-10-08" version="1">MIYRLPLFYFVLSLQQGIIQSIIQRYLYDIQRESEVSGGSVEDVKHSFERLRFDVLSQYQEKDESLAMAMDTVRGVACKLSDTTGRALDYDTPFSGPFPWCADPGNTEDNDSSPLDEYDRYPLSAVAREQEVLFDIHEEAEKYPQEFEENVKLVDESSVSPKDENGDIPFMDESMSSSEGKRIFSVSADKASASETKGGQATGDTPQQNGFFQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZ96</accession>
    <name>A0ABM1VZ96_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC118478377</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118478377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827739.1">
        <property type="nucleotide sequence ID" value="XM_035971846.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478377"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827739.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="53137" checksum="16DA01C1833D0A98" modified="2025-10-08" version="1">MCMFSIGPRVNLSITCVCFLLDHVWICCCCFIFFIFWGVCCFSAGSDLLFHHRRVGQTSHRHLTDISQTSHRHLTDMDTYLFPEFQELFREFPRLARKLSLQELRALKNFLDRRLLAEHSRLVQRVTSLELSRHADDHRFSRAISTLEQESREKRQLAAEYKRGFGNMAQVLANKEGRFEGKYEKVLSQVETLEDELRRERKTNVSLQEDNERRDQVIGNLHRDIENLKRSNEEKSDYHAVLRECKDLHKNLLRAKLELELQRKNNDNLVKELDVLGGVKENKRMSLGDVLATRESLHDTNRSLPITRSGVWPKSFEDSDVTYLAQAKTPRVLAGVAYSCTDPQCRAAYDLAQCRAQLVRTTENNARLGYLLAQARADSSGMDRRYEEKKNDVDVDYYRPRGYVTRHGLTPGIDHPSPPTTTTKPPPGLPRPGASNIPSRHNLSQHRLYQTKNPRPTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZS4</accession>
    <name>A0ABM1VZS4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">guanylate cyclase</fullName>
            <ecNumber evidence="1">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101861837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="1"/>
    <dbReference type="RefSeq" id="XP_035827917.1">
        <property type="nucleotide sequence ID" value="XM_035972024.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861837"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF10">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE 88E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="197"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035827917.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48608" checksum="27E5BA21D1DFA1D3" modified="2025-10-08" version="1">MVDIFTLERPLTSFTWEDILHHTNNVFQLVSKTRASDNDVVEDGGGETQDSDLRKSRKTSKGDKEDTESTTSQINLLQLKGQMMYMSEWDCIMFLGTPIMSSLDDMFKIGLYINDLSMHDSSRDLVLAGTQQSAELKLALDQEQEKSRLLEQSMVQLDQEMQKTDALLYQMIPKPVADRLRKGEPSVETCQVFDKVTILFSDVVGFTTICSQITPMEVVSMLNAMYTEFDQLSETHSVYKVETIGDAYMAVSGAPTVTKYHALHMCDMALDMRDSMQHLTNPANNDSMKIRIGVHTGTTVAGVVGIKMPRYCLFGDTVNTASRMETSGEAMKIHISETTKLELDGYPYDVEERGSIQVKGKGEMKTYWLVKKKLIDDQDLPTCPFVSIMQEEVRARHKEESLGRVLDTSGGVDTRAQAASPIPYSPVSYKDVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1P6</accession>
    <name>A0ABM1W1P6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Gamma-aminobutyric acid type B receptor subunit 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC118478662</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828589.1">
        <property type="nucleotide sequence ID" value="XM_035972696.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478662"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035828589.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="27893" checksum="DD8858B339F539CB" modified="2025-10-08" version="1">MEIWLGALYAYKGLLLAFGCFLAWETRHVSIPALNDSKYIGMSVYNVVIMCVCGAAVSFIIQHQPTQSFIIIGLFIIFCTTITLCLVFLPKKVMEVDNLLEQLGEDVVRDEAALKSALMHRKIMELRHTDGSPSKLSVKLSARKSSLTIPPPAEEEVAGEDDPFGGVYLGPDDSPEKETPPRNHWQQPPAISGERQPLVPNATFWSAPRNKSGTTSVDSLLDHSGAVQGLMTSFGSVDTNPGNLVCSAHVCSLLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3B6</accession>
    <name>A0ABM1W3B6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine O-palmitoleoyltransferase porcupine</fullName>
            <ecNumber evidence="9">2.3.1.250</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC118477120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[Wnt protein]-L-serine + (9Z)-hexadecenoyl-CoA = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA</text>
            <dbReference type="Rhea" id="RHEA:45336"/>
            <dbReference type="Rhea" id="RHEA-COMP:11170"/>
            <dbReference type="Rhea" id="RHEA-COMP:11171"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:85189"/>
            <dbReference type="EC" id="2.3.1.250"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.250" evidence="9"/>
    <dbReference type="RefSeq" id="XP_035829159.1">
        <property type="nucleotide sequence ID" value="XM_035973266.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477120"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF12">
        <property type="entry name" value="PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035829159.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39384" checksum="5D2E9ED8057D6882" modified="2025-10-08" version="1">MRLGWPQNFCSVGGFFGESTVIFLFHLLLSELFMADPATWHKVRGAQILLSMKIISLGYDVGKGTVADLPNIFEYMGYCFNVGTVIFGPWITYEQYYKLLDAEANPMSMVWAAQVLSTTGLSVFCLVYSNCFTHWLILDSVNKWFLAYRDAQSFRFSHYFISFLSDATSSLSGISPDGGSQLQWSVAKPQHIEVPRSLVEVVTNWNLPMHSWLKTYVFKPVRPYGTFLAVIMTYAASSLLHVSSQLRHTFFRRRLSQIFDACVQAKRCKEKCDHKFTSRHPAVFLTNLAFGALAVFHLAYLGLMFDSSDGEDKGYTMWHTLDKWSSLSFLSHWVALGTLVFYWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4A7</accession>
    <name>A0ABM1W4A7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polypeptide N-acetylgalactosaminyltransferase 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106013913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829500.1">
        <property type="nucleotide sequence ID" value="XM_035973607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013913"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF43">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="126"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829500.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29573" checksum="ADB896FEE8F4DFF3" modified="2025-10-08" version="1">MGLLPRSVRRRRSSIIYFVLVLLIIVILAHYFDLLNFPTTHLAHYSKRYIRYQKYKQSEPYRTGPGEQGAAVLLHGEEKKLADSLMDAEAFNRIASDKISLERSIKDVRDERCKSIPYPRVLPTASVVIIFHNEAWSPLLRTAHSVVNRSPPDYLHEVILLDDFSDKEFLKEKLQDYVSETWPDGVVKIVRTQQRSGLIRARLAGAEVATGDVLVFLDSHCEVNTGWLEPLLGRIQEDRTAVLCPEIDLIDKTTLQYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B7U2G3</accession>
    <name>B7U2G3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 9">Cortactin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100533277</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2009" name="J. Neurosci. Res." volume="87" first="1057" last="1068">
            <title>Cortactin colocalizes with filopodial actin and accumulates at IgCAM adhesion sites in Aplysia growth cones.</title>
            <authorList>
                <person name="Decourt B."/>
                <person name="Munnamalai V."/>
                <person name="Lee A.C."/>
                <person name="Sanchez L."/>
                <person name="Suter D.M."/>
            </authorList>
            <dbReference type="PubMed" id="19021290"/>
            <dbReference type="DOI" id="10.1002/jnr.21937"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="FJ424611">
        <property type="protein sequence ID" value="ACJ60629.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191512.1">
        <property type="nucleotide sequence ID" value="NM_001204583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7U2G3"/>
    <dbReference type="GeneID" id="100533277"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11959">
        <property type="entry name" value="SH3_Cortactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000398">
        <property type="entry name" value="Hematopoietic cell-specific Lyn substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035716">
        <property type="entry name" value="Cortactin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003134">
        <property type="entry name" value="Hs1_Cortactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF23">
        <property type="entry name" value="CORTACTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02218">
        <property type="entry name" value="HS1_rep"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51090">
        <property type="entry name" value="CORTACTIN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="519"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACJ60629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="NP_001191512.1"/>
        </source>
    </evidence>
    <sequence length="577" mass="64968" checksum="219D649A5DADD590" modified="2009-02-10" version="1">MWKAGVDVKSVVDTGDDEWETDPDFVNDVSEEEQRWGAKTVEGSGHQGSLNLKQLREQVSMDDKDYKQKEYERGPKASEGYGGKFGVQKDRMDKSAVGHEHHEEVALHSSQTDVKKGFGGKFGVQSDRVDKSAVGFEYAGKVDKHASQKDYSHGFGGKFGVQKDRVDKSALGFEHKEDLTKHESQTDYSKGFGGKYGVQKDRQDKSALGFEYEGKTEKHASQKDFSKGFGGKFGVQTDRQDKSAMGFDYEGKTEKHASQKDFSQGFGGKFGVQTENMDKSAVGYEHQEKLQQHESQKDYSKGFGGKFGVQKDHMDKSAVGYGADTKTELHSSQTDMKKGFGGKFGVQEDRKDTTAGSFDDMEEVKSGYQRTKAEGGSEGARNLKARFEQMAKGGEEEARQKAMEERKRREAREKKEREEQEKQRQERLARERQEEEERQASEPEPVREPSPEPVREPSPEPVREPSPEPVREPSPEPVREPSPEPVREPSPEPERVEDYGEETEYSVEYPAQSQEGGDGDGIMAIALYDYQATDSDELTFDPDEIITNIEMIDECWWRGSCRGVTGLFPANYVELQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC03</accession>
    <name>A0ABM0JC03_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Leucine zipper putative tumor suppressor 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC101845207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090186.1">
        <property type="nucleotide sequence ID" value="XM_005090129.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090187.1">
        <property type="nucleotide sequence ID" value="XM_005090130.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090188.1">
        <property type="nucleotide sequence ID" value="XM_005090131.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845207"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045329">
        <property type="entry name" value="LZTS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354:SF2">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0290503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06818">
        <property type="entry name" value="Fez1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="623"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="848"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="738"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005090186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005090187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005090188.1"/>
        </source>
    </evidence>
    <sequence length="932" mass="101862" checksum="E441E138904EA915" modified="2025-10-08" version="1">MSTGGTDSLPELCGPAQHESRLSVQSPASSYSTYSHEVKYIFEPVSELGGEGGHEVDGREEEVDEYSDYSHIVPRGQNFLSHTPRTLSASSQFSGKENQTPGVGGGFEHPEPPALPHGGPRSCSLSSSGSSRDRGPISPRLEEALYSATNHHHHGHHSARSHAGPPPPLSRSFYGQHADPTHYPYAKHSYHSAWKNGNHLGNSTGGLGSGGVGPGMGPSMQQQHGIGNPKASNVPQNIYRRTGGGLVHPAQNQQQHPQQQQQQQQQQQQQHAHPLNNIHNYSHYQNSLQQQQQQLGQGGHGHMPIEPPYPPPPRYTHQQHFRRKTWSPPALKMSLLHASYQGNRVCHSNDSLDYGQEEPPVERKTLSLSEDLDMTPPRLAPISGVLAQKPGPNLIKPIAYKPTNGSPARSPVGQVARRPTSGEESGGGACQEMPRPIAMRLGTSMLGLQASPDPQPGKGGSGGGNRGAFNSARQGIGAGGASSFTSSDAGLPMPHPTAHPSPAGSASSALYNGAHAPHHPGLPHLNTSTHSYHNASASSQHNLSANSSHISANSSHISANSSHVSGNSSHISANSSRLSGGEEATSLSGEVRPDSVPSLGTSRLWQQGAEIMLQTPSPSDSGVGELEAMLREKDAEINTLREVMDRNERAIFQVYEERRNAWLHDSQELRDDYERKLKVQSRKSYKTEQVLSLQVYKLQQEQKTLQDEKLKAAGEKDTLRQQLEESREEVAKLREQLNLGSSSPKDGSVSETEASQEEVVVKNKEIIRLKSELHALEAEIENKNKELLERAREASTRNDQLSQMKEELGRLKNPAILVEASSQTHTPSEVSVSENVKPSALGERDRAISSLQEELVNVKTQLELLKGDQDKEREQWLEEKNKVVRYQKQLQLNYVQMQRKNSTLETEVQQLTLELENRDMKLIALSGEESVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC89</accession>
    <name>A0ABM0JC89_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hemocytin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101864273</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090361.1">
        <property type="nucleotide sequence ID" value="XM_005090304.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864273"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039675">
        <property type="entry name" value="CILP1/CILP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025155">
        <property type="entry name" value="WxxW_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15031:SF4">
        <property type="entry name" value="CARTILAGE INTERMEDIATE LAYER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15031">
        <property type="entry name" value="CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13330">
        <property type="entry name" value="Mucin2_WxxW"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="F5/8 type C" evidence="10">
        <location>
            <begin position="1077"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="11">
        <location>
            <begin position="1507"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="9">
        <location>
            <begin position="1686"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1456"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1463"/>
            <end position="1481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005090361.1"/>
        </source>
    </evidence>
    <sequence length="1755" mass="189442" checksum="ABE1EB0AE24A314B" modified="2025-10-08" version="1">MSKEELAKFCPNGKITDIQCIDAQTGDDSTSLAEASCTVEGGLSCTSLPFPGIPPCHDYKIRYMCSCSDAVTATPVPPVSVTPNQKIQVNCDWSPWLNADSPDVGNGDMETLTEIRRTFGVCPTIADIECRVAGSPTLFSQAGQDRLMCDVLNGFRCFNNEQKDGQCLDYEVRVLCWGQQCTGPTPTPPLDPTMGPQTTLPTDEAKRTTGSCPPGEEWQSCAFNCEEVCDFMGRSSGACQGILTQEDNCIPGCRPPPELPRTQCGLNERLIEPGVCVPKEMCTCLKPDGTVAKPFEMWDNPERECSSCSCFNGEVICGSMDGCSTTPPPPGQTVAPLPPVCGWSEWMNENKPSLGSGGDMELLSALRPRYNLCDRPVRIMCRDVALKKEAADSGQVVTCDVNEGLKCFDYNNPGRCDDYEISVYCACTPTPAPNESGLGSPTPKPSPSCTSGWSAWINRNSPIGSNGDQEKMTPEELSKFCPGGAITDIQCVDSDTLDDSTSLAEATCSVEDGLSCTNIDFIPPCRDYKIRYMCNCSGAQPTPSPQGTVLSTSKLLSSSSTRGPSTPAPQPVSVITTTPGPAQACTPGWSSWINQNSPVGTDGDYEKMTKAELSAFCPNGQVTDIECVDSDTGDDATSLAEAECNLEDGLSCTNIPFDGIPPCRDYQIRYKCNCSGAQPTPSPQGTVLSTSKLLSSSSTRGPSTPAPQPVSVITTTPGPAQACTPGWSSWINQNSPVGTNGDYEKMTKAELSTFCPNGQVTDIECVDSDTGDDATSLAEAECNLEDGLSCTNIPFDGIPPCRDYQIRYKCNCSGVTSSPSSVGTYNNPSSTPLSNSPVCGWTMWMNGHTPSPVGEEESFTSLRQKYAFCQTSDITAIECRDAATGKSAQEMGQVNVVCDNNYSGLKCLNADQPNGQCLDYEVRFLCEPKGASCKPNAFTNGPLPGSTTTDSPVLAGSPTCTSGWSNWVNENSPIGSDGDKEKMTADELRNFCPGGSITDINCVDSDTLDDSASLAEASCTVEDGLSCKNDPIIGIPCRDYKIRYMCNCSSSTSHSVGKRSVHHLADALPSSNIPVECLSNMGLRSGLVRNNMITASSFRDTYHSPQMARLDSQGSWLAAIDDLNQYIQVDFLTPVYLTGLTTQGRPDAPSFVKSYRILHSLDGINWNPYQEQRGIDMIFEGNTDIFTPVKVLFKHPVLTRLLRIQPVSWHGRIAMRFEVHGCSTEYPLTAPLQLDSQMSQMSEPTEDLDKCIVWDDWQDLSQPGLTSKNDIEPIEDLVRMSPSCKDPVQIECRTATPDLKPAQNSGQNVVCNLWDGLRCTADKANTSMCYNYEARLGCWKSTAECLSKRSTEPKKVSSALREARMCFSGMDSTHCPHMGCANGLYCNGVKCVPRNECPCMVDDTVIRPGAVVRNKDCETCQCIGGEVLCMPKVCPACQVGESQLNKETCSCQCNTCSSGEFQCATGLCIPAEKRCDGVIDCADDEHNCAHTAIFVRKVQPEKRKGQTMCHYTMGNGPVNFKVGDSWQDGLCKLCTCKLTAKGTAESVCDAPACPKCQHGEVQVPVSGQCCGQCVAAGCKANGNVYKVGEVIPGARKCFTKTCQHDSVEGHYFVQESQIECPKLDTLKTCTDVADMLDSDGCCLKCIPQSITPAEIPCESCKPQLMFEDPEKSVGFIKLSKPNGVQCENTKPIRDLQECSGFCESKDRYTETGFQLSRRCCQAQNKSTQVVKLHCSDGTFLSHELDIPQTCSCSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCU6</accession>
    <name>A0ABM0JCU6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="1">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005090775.1">
        <property type="nucleotide sequence ID" value="XM_005090718.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859536"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090775.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40426" checksum="B9F48DFF7152E7E3" modified="2025-10-08" version="1">MTFQKTRLQSAPEQALLKNQNGVIASVIASVIASVIASVIASVIADIHSTTGKLRRAVLQFTPVSWLYVRWLDPNSTTMRIIAVWILIVSWQLSELNTFFLKHIFYVPSSHMLNLVRLLLICLVSAPTIRQYYVYVTDTRCKRVGTQCWVFCAITLTESIICLKFGAQMFRQAVITYVITWLCIQMVGSFMCIYLCAQFAQRWNKWKHYMDVDSPIRIPRIRTISRESSSASPYSPAQCSGDDDEPWKQTGAQPPSSNSRRLREGPAERRTGAGEEVREEEEEREREEEREREEDGEEGNLVVTDKYISAKTESLISGKLLGNGYQLRSRSPLHRSRAERSASSSPKFRSGINGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDP7</accession>
    <name>A0ABM0JDP7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101853672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005091293.1">
        <property type="nucleotide sequence ID" value="XM_005091236.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853672"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043404">
        <property type="entry name" value="ATAXIN1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003652">
        <property type="entry name" value="Ataxin_AXH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036096">
        <property type="entry name" value="Ataxin_AXH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13392">
        <property type="entry name" value="ATAXIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13392:SF13">
        <property type="entry name" value="AXH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08517">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00536">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102031">
        <property type="entry name" value="AXH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51148">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AXH" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="689"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="870"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="913"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1187"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="709"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="870"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="941"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="964"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1024"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1227"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1320"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1348"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005091293.1"/>
        </source>
    </evidence>
    <sequence length="1374" mass="144029" checksum="BF50C89CEE6BDA4D" modified="2025-10-08" version="1">MSSSRFRPGSGGRESSRQLPQPLQGGLHGQVVEASFSSRSHQPDTGQLAQQEVARDTRQFYQSGLPADKVSALQEVRPEWNEPQLGQYRQQDKREFLSHARASTSSQSAAQDTPSGLDGQSLYCSEVLPSASPPTQSGKGEEGAAGRRGVLAVNGGSATQKVQYTIIITDPQLQQNGERRNSVNNTSGASNILLTTLVQQQQQKLQQQQLQQQQQQQQQQQQQQQQQQALTQANRVDNLVENPLPVAASVSGNIFLTNFSAGPVNGSNRLGSVLIGKQPFSSAAADTDTSACGSASSAASATHSADVNSSNKPVDRKHLTANHLNLLANSKLPSAILDSEGNLVILNYADKHVTGNGLGLTELNQVSLTGAKLVHPAAGSSQDLNPHFVHGVIADGQHHQHVLRADAQGNSVGVLVATSASSQVNQHQTFQTGIVNVDLKQDSVQYNGQSVPETEQCESVSTVRRTSSSSSTQSLPSGEPLADAASPPDRPSGGMHSGRPGIGAGQPHSTHTQQQQQQRQHSPLNSSSNLSSAVSAAAAAATSNPTVMLSAGQPAVPSGLFRTGADNPSAPSHRLSGGGAGGSSYVPAQYSTIYGVHGQSPGPAALSGGLQPYNAFFPQFAGSAGASGHGFTHNPLLAASSPGAHYQQFESYSAMLASMGSHVQHRGAQGGDVRAPRVPVAGVPARPGTFLSQGAAGAHPLAGPGGQYPSISSATSSSSASHRRLSGSSSPSPGPAAAASNPAASGLTSRLDPVTSRLDPVASRLDPVSSHHLEKLAALKGAGHDRRLDLDSSRDLRLYGAPSAGEAAAILDEKHQLSPSGSYSASGHVPKVSFDSVVKEYGGGRDSPTGRGDPRDTYFRSHLSGKEGSLKHRILIRPDSEDDSAKVSGVHGLKEEPATKRLKFSSVSAAPLSGYASGGHHEEAHKGERRHHSIGHPAHLSGTNNSSASGGAPADTRPAHLSDSSNNTLTTAHHTTASSMPSSAPSSSSSSSSHHYHQHHLPPHHHHLSPGEESGGDDNVYSKSSYSPTTASSSPPVSGPSAGPPPSATTAAGGGSHLQYPVHFMKGSIIQLANGSLKRVEELQTDDFVNSAEISADLKVDSSTVERIEEHPDRGTAMLSFSVGEHRVQVTVEATLEHPFFVFSRGWSSCSVSRTLARYGLDCQKLSVGDVCISLTQKDVDLKAAEISQQQQQHEHQHSGSPSSPEQHNSRLPAPSTFSHHIPTPPVSFSSPSSSAVLASSSSPIGPGSMKTENPECSSPFPGPSPVSSPSTSAPAIKRRASQAELPPPLSNIVPVKKENNHSRRRGSYNGDSHVKEEDVVKEEEEEDSNSVLQKRHWSPSDTASIKAEQDRERQLRAKETHKADETKSDNGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEL8</accession>
    <name>A0ABM0JEL8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deoxyribonuclease TATDN2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091965.1">
        <property type="nucleotide sequence ID" value="XM_005091908.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845446"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363:SF1">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091965.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33349" checksum="9F679ABAA55298A5" modified="2025-10-08" version="1">MAQFWTKAASLAELVGRSRGYIHKFVDSHCHIDLLYSRLKLGKDHSYSSFLTEQTESFPANYEGCVAVFCYPKTFSANEPDNITLRMAGSTDNVWLAIGCHPKSATEFTDEHLQGLRSALQHPKVVALGEIGLDYSGTFSQHAETQKKVMRSQISLALELKLPLVIHCRDADDDCLVILKEMVPHEWPIHRHCFTQDVVTAHEWLSAFPRLYLGFTPLITRKTDAVGAVKKAAADVPLDRVLLETDAPYFVPEGVKNGVKVTHPGFALFTAECLAQLKDISVDAVLEACRRNTQDMYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEN4</accession>
    <name>A0ABM0JEN4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118477119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerate kinase type-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092004.2">
        <property type="nucleotide sequence ID" value="XM_005091947.3"/>
    </dbReference>
    <dbReference type="GeneID" id="118477119"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="entry name" value="Glycerate kinase, MOFRL-like N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="entry name" value="MOFRL domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227:SF0">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82544">
        <property type="entry name" value="GckA/TtuD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOFRL-associated" evidence="3">
        <location>
            <begin position="15"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="2">
        <location>
            <begin position="311"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092004.2"/>
        </source>
    </evidence>
    <sequence length="456" mass="48333" checksum="6894F09D5BFB8BE2" modified="2025-10-08" version="1">MGSHLVRGVISVPSGVVTALVEAGKEDMLLSSQSRIRVMEGAKDNLPDQAAQAAAQEIHTLANGLQDGDLLVVLISGGGSALLPAPIAPVTLDEVMDVTRRMARAGASIVQLNAVRKQLEALKGGGLAEAAQPARVISLILSDVIGDPLDFIASGPTVPDRTTPEECLDLFAQLSIQDSIPESVKTLLTSTKSETQDQARSVDWSRVHNVLVGTNKIACEKAKETSDELGYQSIILSTEQEGEAREVSQMFATLASYISHLLVDGLSSGNNREEEIQKLERSLLVYPSLSVDKLKEIRQLAVRAKEMQRGVCIISGGETTVMVKGNGRGGRNQEMAVSAALELQRFLPASAQTDLTVQKQDSSTSKTCDEISPPSIVFLAAGTDGQDGPTPVAGAVVSPRFCEQAQSSGVNVIEFLDRNDSYNLLTQVDEGANLVVPGLTGTNVMDIQVLLVKPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEW6</accession>
    <name>A0ABM0JEW6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box only protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101844981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092137.1">
        <property type="nucleotide sequence ID" value="XM_005092080.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101844981"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039588">
        <property type="entry name" value="FBXO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008:SF4">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092137.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49179" checksum="2A69D0D39F59AA78" modified="2025-10-08" version="1">MCAMLVESPLAAVTPLSNVKCGKRETQSRSCENDKEDLPLFLASIQNLLVKYKMYSKSQNVPVASGGLQQFVTQKLKKQSEGSNFSLMKSLRALYGRSESVTLPVDENENGEIAFFQYLPVDLKLYIFSFLDAKALCMACCVCQEWSQLTCDELLWQHRLQCDLKMWPLISHVTNPQMYSDVECEWSTKEIYLRCSPDFHKQLHQANSTFHHVSSVLKYLMPKKVPKAAMFGPGLEQSTSGLVRKMLYEDNQIFTRVAMFPGQFDGVGGGMTLRLGSGHSVHLSVLYSASKQERENHAAEDRLRRNKMLLRLPDGAEGDGESEPQYELTPQIKHLCQTLDAFIFVIDSSESKEAITNGRLELNAMIRERKSAPHIPLLVLSCVKDASKPRLPACEIIDLLRLSSISQPWLVIDCITDTLASVDEGIIWLVDQARYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFM0</accession>
    <name>A0ABM0JFM0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isovaleryl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101863797</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>3-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:12276"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57345"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43456"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57389"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:86160"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.4" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005092564.1">
        <property type="nucleotide sequence ID" value="XM_005092507.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863797"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0274">FAD</keyword>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="20">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="19">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="18">
        <location>
            <begin position="269"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_005092564.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="46367" checksum="5FD90E8CC0F47ACF" modified="2025-10-08" version="1">MALFRTCSRILRPVINGQCVSTIPKRCGSSYFPIDDSLYNLTDDQKQLRETIFQFAQKELAPKAEQIDKENDFKDMKQFWLDCGNMGLLGITAPSKYGGSEMSYLDHCLVMEELSRASASVALSYGAHSNLCVNQIVRNGNEEQKMKYLPKLISGEHVGALAMSEAGAGSDVVSMKLTAVKKGDEYVLNGSKFWITNGPDADTLVVYAKTDPQNPKPQHGITAFIIQKGMKGFSASPKLDKLGMRGSNTSELVFEDCVVPASHVMGDIGRGVYVLMSGLDIERCVLAAGPLGIMQACCDVTYEYAHLRECFGEKIGHFQMIQSKMADMYVALNATRSYVYNVARALDRGERHPNDCAGVILYAAEAATKMALDSIQILGGNGYINDYPTGRLLRDAKLYEIGAGTSEVRRLIIARAINAHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG86</accession>
    <name>A0ABM0JG86_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation machinery-associated protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092986.1">
        <property type="nucleotide sequence ID" value="XM_005092929.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862709"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005092986.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22412" checksum="8B72456FE750DA09" modified="2025-10-08" version="1">MPKVSKRCSSGQDKQNRDRPVHPYSRKALKISKQIVHDKKVESSKSATSVKLEHLAEKLRWFQDNLDDRHLYTKQDMIDLVTEYRNRFSDELDQIRLVQSVGNRQGQTRQHAARESSIKMTIEDETHQFEGSGIEVPDLINKKHLESFKKWDGEPKYIQNLKLRKISANDVKRLEVSAGVVSNEELEEINEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGP1</accession>
    <name>A0ABM0JGP1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101850941</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093284.1">
        <property type="nucleotide sequence ID" value="XM_005093227.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850941"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14718">
        <property type="entry name" value="bZIP_Maf_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF44">
        <property type="entry name" value="TRAFFIC JAM, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Basic leucine zipper" evidence="6">
        <location>
            <begin position="254"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005093284.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43903" checksum="394B25772FFE2EDC" modified="2025-10-08" version="1">MDELAESYIESFDLFMDGHDLHQLHSSMVKSELGLCTSPTGTAAVAAAASPQTQPQQTCSGAGVTAQVTGQLQMPQSPILSAVATSNMGYNSGNSTPANSIPPSPTTPLPASQTSLPSPTRSLSSFGSTFGDRGYFEDWFLKLGSQCSSEDGSSTNKLDVKTSSLDELLRSLEPSNVHHHNPVSPSVKSEVPDVSCRGNNEFDVDYDDDNELDVEDDKNSVASSSFCTLNRQGGRKGGVLSPVSGMSPESSVIDDEDLVTLPVRELNRRLQGCPKSEVQRLKQKRRTLKNRGYAQNCRSKRMLQKSELETTNKALLHKIADLKRQLSASVRERDFYRQRCHLLKTELVRASHTGTTGFEEFLCAVKTEKDYNIFNDLKKSPPSESPKSRAAQNSNENNFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH72</accession>
    <name>A0ABM0JH72_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acrosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093585.3">
        <property type="nucleotide sequence ID" value="XM_005093528.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860006"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046102340" evidence="2">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005093585.3"/>
        </source>
    </evidence>
    <sequence length="282" mass="30010" checksum="744409F4A9008AC7" modified="2025-10-08" version="1">MTTFTNVALLALSLLVLGAQGGLVKRVVGGQQYDDGDYPYSVSLWYMGENNIFTNNTPGMHHTCGGSLIDPEWVLTSALCFDDNFLPGLGNTSLWFVVVGMYGQKDADEDAQFLTIDQIFMGPKYNLSESYGDIALLKLSSAASIDDDTVSTVGYNFNSDCPEVNQSCTVIGWGQTQEEPFGYGAEFPSEVDVDVVSEADCVDFYYNPNVTALMGPIRIDNGTLCAGLPQGGADACYGDSGSPLLCGCDLEDQVYTVVAGIVSTGLGCARAGTPAIYTQVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHJ3</accession>
    <name>A0ABM0JHJ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen alpha-2(I) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093797.2">
        <property type="nucleotide sequence ID" value="XM_005093740.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846413"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045901288" evidence="1">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005093797.2"/>
        </source>
    </evidence>
    <sequence length="159" mass="16288" checksum="8EE55BBBAD76B697" modified="2025-10-08" version="1">MLVFCLVAFLGIGVSLIHDVSSQRFPAGGLGQLGPGFPASPGGLGAAPGGIRGRQIDIGGPLGSLNPIPPLDPFARGGVRVNAPAGPPGGPGPLRAPSRPPQLSVELLFLVDKKARDEWIKKAGTGNTPAEREASAIVAMTEFLHSVVHGVNELYTSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI46</accession>
    <name>A0ABM0JI46_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WAS/WASL-interacting protein family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094148.2">
        <property type="nucleotide sequence ID" value="XM_005094091.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846337"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094148.2"/>
        </source>
    </evidence>
    <sequence length="428" mass="46357" checksum="F95BAA3876F59F74" modified="2025-10-08" version="1">MREGPNGLAISKRMDARPTASLNHYMVQPRGDGYILDVVNPHKPMKSLAEVMAFFVETSGRMSTIPLITNDYSKLGIPEEDHFHDYRNFIHKVNRDVDSGELTDAPDFRESGKTLPRPTSKPVRPHFHHSQTINWPGGRYGEQNSRVGIGSDTYQGPPYNEAPPPPPFPHKQVSPQDAKRLYVNLDSSTSQSKPDINSNSKAQSEIQAAAANLRPVSASGAQIANVSKVQTRQQISQENNQSAVGQNIPSSVQSLPGQMPPPPPFPSIHSPTLPSGSSTQQKNRPLSPTPPPVPKNHPPPLRPGSDGTDQGKPTQTATTGGVKSLQQNQNTPEVAPKPTKVPNVVTAAFRDKLEQTLGGGLSSPPPTTKQAPDFSRPTQQSTANIAQGHNVFSNSPRPSEPPDSVEAADETYDNIDHYSNASMFTKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKP8</accession>
    <name>A0ABM0JKP8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Calcineurin B homologous protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101853379</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095982.1">
        <property type="nucleotide sequence ID" value="XM_005095925.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853379"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005095982.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22147" checksum="3A999F7662A9E37E" modified="2025-10-08" version="1">MGTRSSMLQEEEITEIQKETGFSNNQIVRLYSRFTNLDKSDQGFLRRADFLRIPELAINPLGDRIVHAFFQESNSDTVNFRQFMRVLAHFRPVKKNVQKNKLNDREEKLKFAFKMYDLDGDDMISRDELLNVLHMMVGANISDEQLGSIADRTILEVDLDKDENISFDEFVKAMERVDVEQKMSIRFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM03</accession>
    <name>A0ABM0JM03_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845619</name>
        <name evidence="6" type="synonym">MED19</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096815.1">
        <property type="nucleotide sequence ID" value="XM_005096758.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845619"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536">
        <property type="entry name" value="LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10278">
        <property type="entry name" value="Med19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005096815.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26684" checksum="AD658B34A5E1EB7F" modified="2025-10-08" version="1">MADLIRRQEPMQSSPRSSPRDRGSRSPAYPRQDSSGTLKTTISLVPGKQPSVIHTGSFYLVKDIPDEADITGSTNLLNYYNLEHSYNRFINKKVKEELSAFLPHLPGNIDSPGIQDNSSLRSLIEKVPSTGKELTQLSGSALSGFRLHPGPLPEQYQIMNQMTQKKKKHKKKVKDAEKGSALQLAQTDNATGETEPKKAKRPKKEDEQKDPKKKKKKDKKKKKQKHSPDIATASGGENAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM75</accession>
    <name>A0ABM0JM75_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096972.1">
        <property type="nucleotide sequence ID" value="XM_005096915.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864456"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005096972.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18289" checksum="D1E4382995C6975C" modified="2025-10-08" version="1">MATVSLLRACSRGSRSILLQVQVAPKCASTNVISKPFTASPALASFEYFRARRGPFTPEDKRGKGHMMLASTHWKIERAVALGMIGIMPTALFVQGAVVDHLLTTFIYLHGFWGIDGVLKDYLVKFVPWVGKVWYFLAIVGFAGLVNFNFNDVGVCKAIQMFWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN90</accession>
    <name>A0ABM0JN90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847582</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097673.2">
        <property type="nucleotide sequence ID" value="XM_005097616.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847582"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039278">
        <property type="entry name" value="Red1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563:SF3">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative zinc-finger" evidence="2">
        <location>
            <begin position="2028"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1311"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1504"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1605"/>
            <end position="1626"/>
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            <begin position="1816"/>
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            <begin position="2310"/>
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        <location>
            <begin position="114"/>
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            <begin position="141"/>
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    </feature>
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        <location>
            <begin position="1476"/>
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        <location>
            <begin position="1818"/>
            <end position="1832"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097673.2"/>
        </source>
    </evidence>
    <sequence length="2851" mass="315574" checksum="6A222759131FC5D4" modified="2025-10-08" version="1">MSQGTSRISNDYGCGGGSKEEGELSDDEDPPGVAFRHHSRSVERTTGHQKRAHDPSSPLRSDQYNVKERVTSHSRRTTSQHHSFGAGVHRNKSSGSENFSVRLHDQKWESNRTSVKRKDGHRSHSSQRYPLSPGPADPDEEYSRHRERRESTESTSSAYHSSHTPYNSRFWHNRRFRASSVRPFSPPRHSSSHRGRESPLKSAASLENIAVENDRGHIELELLEKEQERIRAQLKSLEEEEETCKDGKENFLVADDSSEVFVPVKEPPATGSGNSDVDFFADDVAPEDNIEEDEDTDSDDNLDLQELRRLALATSERHLRLLASETPVEISSPAKTLEDSVVVIPDAEPAPLEAEPEVVTVEEDDDEAPVVSVSQTADATGVSDSKDKKSSDSTVPEGKSKHRSRSKESTGGKGSVKSQVVRLGPKTKGKKKRRKETSKEEKKANFSKDWIQQCEKLRQLAEKDPRGALEGFRRLVEGTKRAEKPVVTGTMKDFKRQMKIPVLSEDPAPVSKKGSPSEEAKSAAGKERAKEKKTVEKKASGPTQDNYDEVEMDIVSEAEDEESSSASQLASASLRLGADFSQAMQPIQSLSEAQDTSAAVKEATIAPLPAPPMIPMFLPMPVSATASPMVPNYPHLEAPLPSSVPLPPPHPPPSQPPPPPPPPLPPPPLPPLPSRNGEPNGVWLSQNHSESGPRAGEPSVGAAAFAGKDHPTSSLPGKSFSDDLSLAMFLPERPSHTKLSSDDVQVLSGDLFLQRSKSSYSGADIGFQLRQLRKEQEKYDVNTAAPVEPSKCSDADESSLYPNRRERIMDLKRTIVRSDPSAAGFSETELFYSTTRKNTAPRRSKWDHPAPRFLGSPIHQEDVDGYEPQSSRRLISPEPVGTRSNWISVFHSHPSPGPLHDMDRFVPETSRRYISPRRSNSPPHRDSSVTGSKWAPLPKSRGSPGRLHEFNNYVSERSGDSMSPDLSESGTTGQRTGYGLAEPTFKALEDSRPFLKRRRPIQQHWMKDEPLHASRYSPTTELDTFKPGNTKEYTSQRQSYSPEPKYRRRSDSFSKSPGLIPYQRVQQEDLTNAYQPELPARGVSRHSTPPPYIPTSIKPPGMVPAPGREKSSSDSESDEDPDAMRKRLLMEVITKRRGVLNEIMSSSSSPSVMSPQQDAGLSEAAEERNEAGSTEPPLVTVATEFPSLQRRSPSSFMASPGSQDVRESGELPTDGREESSSLHVLHKVVKPVASESDQNDAVGDTFVGSVMNSGLKQTSSDSEDEEEVLPPPVVKRIERSPTHAQGAAGENSPAGSSPRTKSVATTSTHQHYDAAADALSVISNPVETASDTLNGAQTVPNFSSEIMNFQTVWPDQSEVIARPSSDMPTLSSNASASCEQYTTAPELSGNQTLTTVKKCDFLPGQSTWDPANANSIPHFPHGSLSSQSGVRPESSARYEQGLNSSSSANSTQSPACLPTQSLSDSSHTVPKKSPDHSSLFQSEPLSSMTSDGFVVSPAVVSEQPSGVNSLRAYPDPRNSSGARQAVLEEPSLPMSQHLSTVVDQVPPEIASQPDSCGQTSVTTSKFSHGYLYSTSGPSNSAGKHSYPAKPLPVHPPVVVPMDCSSASEDDHEDMHGSKPGSGADSWLMEDEDISKLDPQMVELKRREFKLKHQKGVVQRGQEALRELVQKATRSLKLQHQAEKKWEKLRLQIILLSEQARVAKKIARAHEQQKEETKKKAWSVKDRLLKQKEEYAETEKATVVLGKELIGPEYQVQLAQIVNASDQRQKFSKAQTIASKKQKLQERERQISEKLRFMKEQILSTSSLKSVAKASLSVKEPEKPLAQRQKSQDVIKLNSSQPDQGTAVVNRRKSLLELNSSTIPNLPLTPHKPKGTSHSEKENMEGEQGQGGVGIEDGLSASKSEEGVSQQNFRMPAGVQLVNLCKLQKEKVEKQLRGPRHMLSATSSYKFPSLSSLRSSIVKKSRVVSLTKRSSAPDSTSVQPSCPVNYTSPLLTFRSYRLSPYYRTREGLSFRSNTYSHKLNPHCVLCPYDIQGICNDDTCKQQHPKDYELSDKELLQDIVSYCPKLAGCGEGASTEEVKQAIVSYVDGVVSRHKGRMTTEQLCLWLSSQVKETAGLKNPHTVFPLPRTWTPEPKEEAGLSLFLNPKPSTRVIDAIRKEPPTVIDQDVVQGEEDVRYFAPDNTELLSLERAVLQDPTDAAMWQRLADKKLADPDRSARECMDNALNVLARGLEANRHACTLWQRYLALYCRHPEADNFLQFCRTGLEYAPSYDIWFLYLNSLKTYSEKDGACNQALNFLDTGSGIEPKSSVSLADRESQGQGGDDDTCLTDVPKSPTSTDKSTRSHQALEMILYKACLNLLSGRLKTTLNFLQSVLGLKSTPSTPLRASSLLTTADHLVLWLCYIHVLEWHQLPPDLYSPTDQNPGRLLSKAVTLHWPEARPLYSSRDTLIKLHKKAIRVGDKAVLDLEATRHYVQVVRSLFALLSLERPAEAVSLSRSVLSSRNLEEIWLATADLYASFKDKDGVKQVFQEAVKVHEHSAKLHFYWNSFLMSEGETEEALCNLEQFVINQFDVDTRESQRCDPNQLYGQLLGQQEAFSLQMLRIKPQAGGDEKHKNIYLWLCYSLLLELQGERVNTVEIYERSLTHAQTSDDLVVAWQNYIGFLLRTEAASPEDLHSLLSRSIISMPTKSPVPLRPTAHWLDYRHCNTLVEAWLAVLDGANRLDVAEFCLGCMPANMQLLLRVVELCLANKETRRAYSWCKMVAAQTEKPANLAFWRITSALAQEEGTAHEKDQMLVGCVEAMPLAVAGWKDLLLYEVSRENSEVVHRLLSRCLQLGVNIEGYVATISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPU8</accession>
    <name>A0ABM0JPU8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850335</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098716.1">
        <property type="nucleotide sequence ID" value="XM_005098659.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850335"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098716.1"/>
        </source>
    </evidence>
    <sequence length="1115" mass="122731" checksum="C8D6453370862439" modified="2025-10-08" version="1">MAKGSNMDVEDSSDCERGKVGKKRHNTRSLDNPMVTTDSSTTGNDSNKCHEELQTNTEEERRRKAALAAKKHHACAKIKRAKLIQKNEDLSNEQLQLLRDIDRLMEKQERLQDLLDHHNCSDDQDTAHQLDMREPSWKEKDNLPTTVRPETVSLHSPEQASQSRVTCDIGLETKSVESDLVAEDESEQTLSSQVKNTDKTDSEDLQKSTVISPCRSRESSQNGTVQQNETVPQNETIHQIEKVQQNEIVQQNDFQRQVQMLRSKPIWTHPVDLPGKKDVELMEALCHNSKWMSGTVVTFDKVGKSVDDAAQASKQSGGRSKSESACASAQLALVPEVLRSGRQEILRANGQTRHNSASSSRRPKLAQVQVVRRVSHEELSASSAGQGHKLDPLSSPVVMISEVDNGKVFETVVTRPQTCTDLVSGQGKKSEKLLASLRETRFQSVERPAVGVQKLNTPPAHHIATHVLRGLPLSSQSGEVRVEKLPTTVTEGMTPLDQQVKEQTPRGSSERQKHVLVEERGERQKCVVVEERGERQKCVVVEERGERQKCVVVEERGERQKCVVVEERGERQKCVVVEERGERQKCVVVEERGERQKCVVVEERGIKAEKGEPVLSAEERAVSDVFTQRRAGGVGSCTGGVSVSADGVCVRPVLVQEFLKVDPAVVEGRAERSSALPPQSLIGIVAKGPWKTSSDFGLKAFSDSARRKVTPVTVNGDKPKLESVTDRHIGGDREKSPQTLILRPVDCVKVEAVHHVHVDQSHLPVFCNSPDGDAAATTQDLSLPLTKTSPKPSSGSTDMNIPVFIQDCVDTMDCKQSVVSVGSVSKATTSCMFTPPAPVLSQQVGSGYRFLLEINEDGIKKTYPFPFANAPKFVTSSTFSESSNTKAVSICSVKTAAVAAVTSLPDVSETPLEKKFSVQSSTARMPDEALSIKQKNLLPSTDIFGEFSSPEPLTSQEKISSFSKFGNYEKNPFRTFVPKRSPWTAASLRTAQCEGKVERTGQDESADWEHGKVSGSTLTTAPLPTNLKEHRKANVSVLSFDTTAKKRRVSAEATHSVVPSQPTAGKRTKLVCESERLNSAAAKLRAGKKTKSRIYKPRFHHLERAVSIISESLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQC7</accession>
    <name>A0ABM0JQC7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription termination factor 3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099064.2">
        <property type="nucleotide sequence ID" value="XM_005099007.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851950"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF112">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099064.2"/>
        </source>
    </evidence>
    <sequence length="461" mass="52149" checksum="E47997119FF65A51" modified="2025-10-08" version="1">MVIVIRNLMQTQCCFLKRVKLLLEVQMMCRALHVHRKCLPLSGSAPMGTSLQGHIATKYTPSMRLHSSRSPDSSCRLSFRQANGLGHIEPQCWRVQVKDFSIRCYSRGSRRGLERKRREADVLDVAVAAEQVEGNLGETEGSALAEYADDSDDRLSIDLTTTSQDSSVDLHSRPAADLSVPELSRRAMNLVPFVNRSETLQKLVQLGVDLSVVQQVEGMSTLLVRSDFERDIMPYIRFLADVGVPADRLGHVLTVNPHILTEDRAELEQKIGYLVHKKFSLQEVARMVCRAPVMLLMSPQQMDQKLGFLQQTFGLSGPEVRLVAVKYPKILPYKKDKIALTRFQVKGFLGFSDVEMKEILLKEPRIFMTENRQLVSTFDYLHNTMLIPHRLLLTFPGALTHSPSALRTRHLFLLARHRAQYDPCLENYVSLKALVSGTDDAFCADVVKCGVQEFYDFIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQI5</accession>
    <name>A0ABM0JQI5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101861209</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099192.2">
        <property type="nucleotide sequence ID" value="XM_005099135.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861209"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047473179" evidence="3">
        <location>
            <begin position="26"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099192.2"/>
        </source>
    </evidence>
    <sequence length="320" mass="34608" checksum="287EE13FE25CD83B" modified="2025-10-08" version="1">MSEQRYSLLFICMWILSAFAGLSNGGTLQQCSEEMAQEAEIILSNSDMCAPLENFLVCCLRVLYEEDRLTPGAVQAVKENIDGSLLSLGINCTFDIDQLVKNVRDGTAITKKPVVPEDSGNSDKHGDGGTQMCIKNYMDNLKALFSIQEACGPMKTFMLCVLRALDVQFHEMPEEKKRKLQADLDTQMMGLGVTCSFTIDSLAEELRNKDSGVSGRTDKSGETGGSKRTDWFKETGVSDKSDESSGTRGSSSNSGYDKATESSTSTRTSESSATGTTSTTAGTGETDGPRRNVATAIASFGFPMWALTILALMLSKDILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRJ6</accession>
    <name>A0ABM0JRJ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Kelch-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101847659</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099881.1">
        <property type="nucleotide sequence ID" value="XM_005099824.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099884.1">
        <property type="nucleotide sequence ID" value="XM_005099827.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847659"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF466">
        <property type="entry name" value="RING CANAL KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="65"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005099881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005099884.1"/>
        </source>
    </evidence>
    <sequence length="603" mass="66459" checksum="02F898A2326ECC6B" modified="2025-10-08" version="1">MSGEHEHSPLSSSSSSSSTPTTVMSSIDVKPKILCGRERPVYKHAQHAHKAFESLNEMRRMGLLCDVCLVAGDLELHCHKSVLAACSQYFFAMFTNEMSESKASRIVLLEIDPSALSLLIDFVYTSEIHVTEDNVQTLLPAANILQVTEVREACCEFLQAQLHPSNSLGIRDFADLHACTDLFNYAQTYTEQHFTDVVHYDEFLSMGVEAVCKLISSDRLTVSSEEQVYEAVMSWVHHNLPARQEYVEQLLENVRLPLMNQEYIVQKVEEEPLVKANSRCKDYLIEAMKYHLLKTDQKPLYKTPRTQPRNPIGLPKVLLVIGGQAPKAIRSVECYDFQEERWYQLAEMPSRRCRCGVAVLNGLVYAVGGFNGSLRVRSIDVYDPLKDTWNSCPSMEARRSTLGVAVLNGNIYAVGGFDGAAGLDTAEYFDVRAGHWKSMASMSTRRSSVGVGVVGGLLYAVGGYDGASRQCLSSVECYSPLCDVWSNVAEMSCRRSGAGVGVVDGLLYAVGGHDGPLVRKSVEAYNPESNSWSAVADMHMSRRNAGVVANGNKLYVVGGDDGSSNLGSVEVYDPSTNKWTLLQSSMMTGRSYAGVTVIERPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRQ8</accession>
    <name>A0ABM0JRQ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein kinase Aurora-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100031.1">
        <property type="nucleotide sequence ID" value="XM_005099974.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860499"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100031.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40665" checksum="69013D3FEDDDB42E" modified="2025-10-08" version="1">MPVLKEAKYRVLNKDALEILDMEQMELLADRGNWEVIVAARARQPKVKRVLKKFLLFEDDDHTSRMWKWSSFKHELSFLQSLEHHNIVRVLAAFQCPSYLGIAMGYHPTDLSRGLLDVTYSEAESYTRQLTDVMCYLHGQRIIHGDLKLGNVLLDRAGVVKLCDFGHSQVIPQDTDKPNGWGGTNGYLPPELYDSQVHNAFKMDNYSLGILLWALFFGTAPCDNIDYLNEVDNGWFLKPQHTHCLQRLLTLTPTLRAHIWEIAGILKDEDTSERCVRKGSVCSLSSESSSDSAQANQSSPDNGSSVTERPESAAVWNQFLAPPPPHPQTTSCYLLPQTAYPDSGDVTTSLAPTWPPLHKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRS8</accession>
    <name>A0ABM0JRS8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Programmed cell death protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100062.2">
        <property type="nucleotide sequence ID" value="XM_005100005.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847590"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005100062.2"/>
        </source>
    </evidence>
    <sequence length="383" mass="43972" checksum="A514AA5C9A79216C" modified="2025-10-08" version="1">MFDSICTCCSVYNKMAAPVSEKTVKLGFLEEIDSQLLKSHFFPSKVGGRPAWLSLDQLPDPSSLQCSECNGVTRFLMQVYAPLQSRDDTFHRTLFVFICPNPPCSSKSVTKSFKVIRSQLPLLNDFYSKEPPSEEIPEDFDSEQYPHAGKFHPLCKVCGVKGPKKCSQCKKASYCSKSHQVIDWKTGHKKECCKENKKKTGSGSQAYESELFKEFELVTEDEVLPAESNNNNSKSEEECLREYERLMESQKFQSSNEVYQLEELEKTAKGETEEDKAYLKFKERVRTEPSQVLRYCRTDEPLWVSLYQRPAAEDIPNCPLCGASRVFEFQIMPQLLNHLDLDRLEASVDWGTLCVYTCADSCSIGNTYREEFIWKQDFYNPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSU1</accession>
    <name>A0ABM0JSU1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase-like protein 7B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100686.1">
        <property type="nucleotide sequence ID" value="XM_005100629.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853006"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="84"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100686.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29281" checksum="81CAE1D6239EF9D2" modified="2025-10-08" version="1">MSHFDAALHFCIFYLVFPLLCLWIIAHYVFGMRFKSVKLKFEAAACYYFCGFFHSRLCSKEKVLLFRSLPDLKKKLGVPSLNVLEIGIGSGQNFSLYPQGTKVTALDPNPDHEHFLRKNLERHITFNGFIRAFGENMSQVESESFDAVVCTLTICSVRDPDAVLKEVHRVLKQGGVFYYLEHVAGEKGSFIRSVQDWLQVIWPYFTGGCSVNRETWVYLDKSRFRDVQYRRYSANTWLAFFIRPFLYGTAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU33</accession>
    <name>A0ABM0JU33_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O(6)-methylguanine-induced apoptosis 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101851050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005101520.1">
        <property type="nucleotide sequence ID" value="XM_005101463.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851050"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35678">
        <property type="entry name" value="PROTEIN STPG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35678:SF1">
        <property type="entry name" value="PROTEIN STPG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101520.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38554" checksum="A5B71911266E2716" modified="2025-10-08" version="1">MADSVKVVDNRTFKRYHARASSGHIHKGGTYSIRPEIGHSIVAANASIPTKFQTIVTDNSDKKGFLARAKRFKEDAFITEAPPPGCYGDIPKVDKISPSYSKKGTGSFASKSKRQGRYFSSAGPGPGSYALPSLLSTRKDFNKCQVERLFQMPIAEAREKINEVPAPNSYEVLKYKSGKANNVTANAAFKSTSKRELMNLSEQKRNPAPGHYEINDDPLHQSTKVPFSSFKSTSKRQMQPDADAIPGPGAYDPNAPVEQPAKLIFPRKHYLCISAPAMPLPMTPPAPGPGAYEVRNFEDAPKHYMSSSAFVSTTGRWAVQPTSGEMPGPAHYRPVNVGKQSFIFNSSRRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW18</accession>
    <name>A0ABM0JW18_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein P2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101856443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102846.1">
        <property type="nucleotide sequence ID" value="XM_005102789.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856443"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005102846.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="11410" checksum="B9F9B187654B168C" modified="2025-10-08" version="1">MRYVAAYLLCALGGNSSPSAAQIEKILSSVGIEAESDKINKIIGELKGKDLEELIAEGSKKLASVPSGGGAVAAAPAGGAAPAAGGAAPAEAKKEEKKDESEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWA9</accession>
    <name>A0ABM0JWA9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-1,3-glucan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101858724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103023.2">
        <property type="nucleotide sequence ID" value="XM_005102966.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858724"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005103023.2"/>
        </source>
    </evidence>
    <sequence length="100" mass="11338" checksum="DF395FC4DF1B4B14" modified="2025-10-08" version="1">MAVYPPSGGFWQKGGFSGNNIWGGNKMAPFDQEFYMIFNVAVGGTNGFFPDGNHYPTTKRWKNSSPHAAEDFWTKRSTWNGSWQGDNVAMIIDYVEFKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXE9</accession>
    <name>A0ABM0JXE9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101862962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103806.1">
        <property type="nucleotide sequence ID" value="XM_005103749.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862962"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="77"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="223"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005103806.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="45830" checksum="A7AD7641891F1753" modified="2025-10-08" version="1">MVRNRPAGRKIGNVAPEDMKAAVEDVLSGGSSIRAVSARTGIGFSTLNRWVKKAKSSEDPEALSYSPHYNCRQVFSEAEENALKDYILTASKIHFGLTTKQAQELAYEFAVSNNKTFPEPWTKNKSAGIDWFQSYMKRHKDLSLRRPETTSLSRATSFNHANVSKFYNNLEEGFTKYKFCPLDIYNCDETGCSTVQKVGNEKVIASRKERQVGKVTSAERGVLVTMLCTISAAGNTVPPFMVFPRVHFKQTMTHGAPPGTTGTAYTSGWMTKDSFYEYMEHLIKSTKCSKDHPVLLILENHETHLSLKTIDKARDNGVVMVSLPPHCSHKLQPLDCSVYGPFKSYYNQACSVFMVNHPGQSITIHNVAEIVGQAYPQAFTPRNIIAGFQVTGMAFQPKQIHRGGLSLCIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXV7</accession>
    <name>A0ABM0JXV7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101856365</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104113.1">
        <property type="nucleotide sequence ID" value="XM_005104056.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856365"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104113.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="33864" checksum="9008356F0FF19D39" modified="2025-10-08" version="1">MKDRLSPVQTETLTVRVNVLDDLEPTVIAENDCLENDASDVESRSHELTTSKTARSSVSTNGSFSQHLAADDETERSHSFLESPEIVVNTDAEPGPRGSGEVTSSLTSAADDGSSRWSSSLSQQESNPGGPRRSEQHSLVTSCSGETASPVEPPAPSDTQDAPPNTPVELYFSQPRPPCHDFLTSGLDGDRKCPQTDDVTGRHHHVDKSVREFEETDVKALWKVLRGEKGASLVVRGGKSKEGKKEKGGKRGGNKDLEQINGMERMLSCIKYVSSVSVDRTDPIYRHLDASATHHHYCFTFLLSKEKFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYX9</accession>
    <name>A0ABM0JYX9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101857663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104813.2">
        <property type="nucleotide sequence ID" value="XM_005104756.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857663"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20237">
        <property type="entry name" value="PFM_LIN24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004991">
        <property type="entry name" value="Aerolysin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369">
        <property type="entry name" value="LIN-24 (TWENTY-FOUR) LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369:SF6">
        <property type="entry name" value="LIN-24 (TWENTY-FOUR) LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03318">
        <property type="entry name" value="ETX_MTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104813.2"/>
        </source>
    </evidence>
    <sequence length="326" mass="36813" checksum="D017C3015F7FA5D8" modified="2025-10-08" version="1">MPFCCCASQAEGKDNYTVDLNKLLCDRAWMRYKNTLHPLRRLFTNRKSFTIEVQDKHFVFEKLEQTIEPLDSRLHLKKNGRNENSKGDKASKDESLLAGKVSEKRPLTNPEFVSLDTQFSNDTAAPQTYKFRFEKQRRSRVTVSFQRGFTLGGKAKFTVGLPLAGAEASLQYQVTKSEGETFEESLLMEATSDISVGPHSKYLAQIQLEERKVLADFKVVMRMSMPQGEVPIHIRRKSDDELLFVYYIENLKDLFLHGAVPCAKEVKTESGESVQSQIDLEVEGVISGTVACNHRIQLTSDETLQAKQEARTKYLQGQGLADSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ43</accession>
    <name>A0ABM0JZ43_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846978</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104945.1">
        <property type="nucleotide sequence ID" value="XM_005104888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846978"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045080802" evidence="1">
        <location>
            <begin position="24"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104945.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="59255" checksum="DA599B3C83AC2D0D" modified="2025-10-08" version="1">MLQNALRYALAVFVSCLLILADCRYNRYSYGAADKETQEKLDILLNEMARLKKENSAIPKSCLKSDAPETQVSAYIIPILVKREATSTELIYTVRYKLNTDVPPVVTWYRHDAGEYKDNVTDTQIYDEDDYVRETVAVFDVYYSEDVIVKLAKADFGELFLGLDNSYNYGSSPNKTEVDLPDPSLTFKPSGDIVYTPGHDVMIKVFSLRADAETVSRKTFNVNGHFYNGMSMNVKNEIGIGKKGNFVNDLKTVDFIDTQEKNILLRTSSRSEMGLLVFQNTIHTRGRSRFFEWVNVTSYKILRPSTQATPFPKGYIGIFPNNPNGTVNLCNFGRDDKCLIKCSGYGNNITDFLIYRIDEGGNKSEIPHEVSHVYLNYSVESLADVLGASTLQNAQQVTYECEAKDSAGNTASAYHVVNFFRSLTFQYNSSGIRYIDNTTAVVTCGALVDPPTGVNIVFSGDFENQYNVYLENTSVEEIPGGLIATTVIDLNEHPEDLKRVSCNGLQELEDGSAMFDTIWVFPPERSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZB2</accession>
    <name>A0ABM0JZB2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Tubby-related protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC101858431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105068.1">
        <property type="nucleotide sequence ID" value="XM_005105011.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941699.1">
        <property type="nucleotide sequence ID" value="XM_013086245.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858431"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF2">
        <property type="entry name" value="TUBBY-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="869"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1101"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1155"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1235"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="751"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="880"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1062"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1101"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1172"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1240"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005105068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012941699.1"/>
        </source>
    </evidence>
    <sequence length="1461" mass="159037" checksum="BF85F26AD6DFFAAE" modified="2025-10-08" version="1">MHVHFEQNTCTRTDSNFLSLSWMGKVPEDLPEEGRGWKLEHSQYYVEGWLASGNARGVVGVTFSTSHCHKYEAPPRSNFNLRGHRSEVVLVRWNEPYQKLATCDSRGVIFVWIKHEGRWSIELVNDRDIEVTDFAWSHDGRMALICYRDGFILVGSVAGQRYWSSMLNLNNTSITCGVWSPDDQQVIFGTLDGQIIVMSSAGSVVSQVSIHEGSEITSMAWSCERFNMAEADRSAADNTSRGSESSGKSHVLAVCFKYGDIFLMSGYDDVCPVMVYTTLTGVKIDWSNCGEYLAVGGFVRLPNLQCRNEVHFYSKDGILIHWVTIPSQGKPLAAMTWGHNDKRLFLAAGCHMYVAWVSKQVAPLHFLCQRVLHQAVRTEKAVDKLPIPQRLRCGVKALFSPTIKSYIPDPLRLREFVCSPPPGGERLFCTMIRHGEETSGGHYTLYLEYLGGLVPLLKGKRASKLRPDFIIFDPKIKSSSKVDPQPGNAIESDSSSESEAEVYTDGCGSPRMQRRRRHKVFRAEKVNRSITFRTLDELMYDDNLPETTRLVEVTSNIWGTKFQITSNASCLPVCLGQVVYKTSLLHLQPRQMTITISEISPARYVLSRDPNFTPAPVSDDEDSFWTSEGDLVGEKKTVEVTVHDAQSLSSVDHGSRRNSSSVVETGVRPTGTDTPLIEHSLPLNGDLSSLAGKLSSSGTVRSRSLSPVRNSLTQSAPAFKPEGVSVDGRQDGNTGTSMGWQGARPKANLTNKKSNNKDSSSNSSSIISSSNNSSGSPKMGASNSIKFAAVAGSGAQVVSSNHSASQYANSPGSLSHSSPPCANRVEAFPLNATSSPVIGHKKIENHSGFKRLDIEIGVQGIDLVTVGGSLSSGQRKPEESSTGSLAQQDSSSSSVSTASSESVLISALDIGPTCSQRWAEPVPQPVKLSEDELSTSELAFENNLVADCSPTAPSCLNLQRRLYLAQQNIMDTSSPISPSSCPSCLPAHLAALLPHGAGLSDQVTQQNFRNSSGLSSASRSSEHSWFDPSPLESEKPKDKSLGASAITHSVDAQRTSSSSSHHCSDIRDKQGGDSDMDSASGHASARANVCRNCRAQQDDTVAAQQTGSSGTSSSSSSVLSSATASGGGSGSDKSQDHCNPSAPVDKTFLCRKAPSKDSYSSLAPHETTRVLPPASSSSPSCSQPQSSPAASTDAGPSMTRELSSLDRLHRILSEEPSAQYSAHNFRSMPGFVMKNPDLINGDDDDDLEADLSSPDQEDILEDDLPGSYLLGNSLLDSDVHDLEIQQTSASLPSSPVRFGVNKQNNENLQEELLKGRCKHLSPLLGRKAGPRDSQTRSQDVFLEDYKFSQAYHSLEAFQKAQLRNKMRKRMTGSSGRMEQGRTFTMHNKAPLWNETSQVYQLDFGGRVTQESAKNFQIELRGKQVMQFGRIDNNAYTLDFQCPFTTVQAFAVALANVTQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZB5</accession>
    <name>A0ABM0JZB5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Cytochrome P450 3A24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101859879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105075.1">
        <property type="nucleotide sequence ID" value="XM_005105018.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105076.1">
        <property type="nucleotide sequence ID" value="XM_005105019.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859879"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005105075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005105076.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="59882" checksum="7D7DA22C732A6910" modified="2025-10-08" version="1">MATTDTASAGLVPFDVTTVLLTATLGLVVYFIYSLFKPTEEWEQYGVKQPQLPRLGFIDFRAGFKKLFEEYGDIVGMKSADLQLLTRDLDLLKEILVKDFNYFVDRSTALVSNTSMPLSLFFAKRQNWKRFRRIMSPSFSTGKQKIVGKTVEETALTLTRFFEECARKDQLIPIKETTGQYTSQIIAKTAFGFNTNCIGKEDDQFTHYSKNIFKIRSKISMYLVLLLIRFPILQQFLVKTLKLEYFDPVYQDADQYFRSVLRPSVKHREQLQREGKKNPTDFLQQLVNAKIGSRTDGERTSTGLANGHGPEVSQSLTEEELVAQSLLIIFAGFETTATTLQMALYLLARHPDIQDKLYEEIQTVVTSQSPSHEELGQLIYMEQVINETLRLYPPVPLINRKASETRTYGSVTIPKGAEVVVPLGLILKDPKHFPDPEKFDPDRFTEENKAKRNPMAFMPFGQGPRLCIGMRLAYLEVKMALVHLLRKVKVEMNERTEPKKGEDVVVSSQGLIVIDKPIKLACKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZS0</accession>
    <name>A0ABM0JZS0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Radial spoke head protein 9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101846756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Kinocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the flagellar radial spoke RSP9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105373.1">
        <property type="nucleotide sequence ID" value="XM_005105316.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846756"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006802">
        <property type="entry name" value="Radial_spoke"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055316">
        <property type="entry name" value="RSP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04712">
        <property type="entry name" value="Radial_spoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005105373.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31232" checksum="4A6C8A218D68BB06" modified="2025-10-08" version="1">MESDGLHLSIDYVGSSGVMLSPESKAALQTSLVILQNENKFNRVYFWGKILGVKDDYFIAQGVYKDEFAGRKTFYSKDCIHWGLLPPATAEMKEKSKLAKGRFTGDPSYEFEHVETKKVGEGEEATEEEETTIVKEEDRLSSVIAEIDDDVRIVPRGAFVQVPTAEVVINRSFEGLSVQEAAKLCNYMHFREAKRLDLKTLLQRANMDKAIDFMDSVEDDVPRGSWSLQFERGSGLLTLRSLQWPGYAFFHIPATHKYGSVYFGTGEKNQDLPFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K042</accession>
    <name>A0ABM0K042_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alanine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101861604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005105612.1">
        <property type="nucleotide sequence ID" value="XM_005105555.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861604"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="106"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005105612.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="55455" checksum="714706C1DB6F2A73" modified="2025-10-08" version="1">MFRLRAPTTMLCKSKVVEKALSRGKVLTIDNMNPHVKNIEYAVRGPIVIRAGEIEKELNAGEKKNFTDVIRANIGDCHATGQEPLTFLRQVVGICAYPKLFEDPSLPEDAKQRADRILNSCGGRSLGSYSDSAGLTVVREDIAQYITERDGIPADPANIFLSTGASEAIRNVMKLLMTTLEGNDKSGVMIPIPQYPLYTATIAEYNAEPIGYLLDESNNWSLSLDELERSLQEAKPHCKPKAICIINPGNPTGQVLTRQNIEDIIRFAHKENLFIMADEVYQHNVYAEGSQFHSFKKVLTEMGPPYSEMELASFMSTSKGYMGECGFRGGYVELINIDPQVKAMFTKAISAKLCSAVTGQAAMDVVVNPPREGEPSYELFKTQKDTVLSQLAEKGRMVTSTFNSIEGMSCNAVQGAMYAFPNIDIPKKAQEAAKAKGMAPDFFYCYNLLESTGMCVVPGSGFGQKEGTFHFRTTILPPVQKLGEMLGRFRDFHVKFMEQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0Q4</accession>
    <name>A0ABM0K0Q4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC101856834</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106021.1">
        <property type="nucleotide sequence ID" value="XM_005105964.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856834"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17340">
        <property type="entry name" value="MFS_MFSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="26">
        <location>
            <begin position="48"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_005106021.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="52604" checksum="67A69F9947BE1157" modified="2025-10-08" version="1">MSDTENASEKTALIRNSYEDSDYEEELEGCSGTPPCNPRSCLHRYFPVLIFICFLSFGSYFCYDNPAALQDTMIRDLDIDEGQFMAFYSFYSWPNVVLCMFGGYLIDRLFGVRLGSIIFSLFVTVGQVIFALGSLFNLYGLMCFGRFVFGIGGESLAVAQNTFAVKWFQGKELNMVFGLQLSFSRVGSTVNMNVMQPLYNLIDEHIHGYKCLGIALFIGAGTCIFSLLIAFTLAFFDKRADRILKRQAISSEEMIKFRDILTFPMPTWLISVICVAYYVAVFPFIGLGLVFFEMKFGLNPTSANAVNSLVYIISAGASPFFGFLIDRIGKNVFWVIIGIVITLGCHMMLAFTFMNPYIPMVIMGLSYSILASALWPMVALIIPAHQLGTAYGIMQAIQNLGLAVISLTAGIIVDKSGYLILEVFFMAWLCLALIAAVLLYLVDAARGGKLNYSSKKRNALKELEDEEKLKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1F0</accession>
    <name>A0ABM0K1F0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vicilin-like seed storage protein At2g18540</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106501.2">
        <property type="nucleotide sequence ID" value="XM_005106444.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849155"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038891">
        <property type="entry name" value="FSIP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21856">
        <property type="entry name" value="FIBROUS SHEATH-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21856:SF7">
        <property type="entry name" value="FIBROUS SHEATH-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106501.2"/>
        </source>
    </evidence>
    <sequence length="344" mass="41486" checksum="9C466EF8E196F6F4" modified="2025-10-08" version="1">MSCKQAMDRLLLPRPLHEPQGAEPPVPEALSPLPRWQTLPMDAKFPVTPAPRGELTFVTTKMGEPAYKSRQRVTFDLSDPYNRTRSSEYQALSDPHLRTWFARRATRKQIMSQKLVTEQGYVPCSVRDFNNYRNFLRHQALVGRHGNDNNADRATERRQLKLTETKNRAGELGVSVKYKVIRAQHRARQEAQERRRRLEEKQAAEAERREEREAMDLRRREEKAQERKIRWEERQQELRLREEMARRRSQSAERKFESEALKKLLLVDKARETREELIERKKKESWEERRRYQEHMLEEAERQRNRVEEQIRSYRERYEVDMDFRLPKDEGRTRCHDVVHCVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2G0</accession>
    <name>A0ABM0K2G0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ELL-associated factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101862826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107163.1">
        <property type="nucleotide sequence ID" value="XM_005107106.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862826"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005107163.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="23943" checksum="12686C62454F2880" modified="2025-10-08" version="1">MSLPVDNDVHKLKLGNSFDPNSKVGFHSIRYDFKPASVDTSQEACVEVGKGNQVTVTVPHVESSGTSHTVFKGNKQPLMKECVLIIDHEKGTYTLEKLTSKIAVKKTRQESSSRALQHSTGRVTPVEKKSSTSSSTPSKVKPSQKNSPEGDNFSITPIHSEVSKGAEDIALVGEITDSSDEDEAPKATSSKKVPSQPPGQMRQFGVLDDDLALSESGSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2Z9</accession>
    <name>A0ABM0K2Z9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-secretase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101859129</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107565.1">
        <property type="nucleotide sequence ID" value="XM_005107508.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859129"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009119">
        <property type="entry name" value="BACE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009120">
        <property type="entry name" value="BACE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01816">
        <property type="entry name" value="BACE1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01815">
        <property type="entry name" value="BACEFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="105"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005107565.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="61173" checksum="1D54C8124D0D2BAA" modified="2025-10-08" version="1">MALQHIAKFWSVRRMPSCIFPSHPTAVALIVLLMMQSFFVPCVESAFRLPIRRFNSHIHVKQHTEKEAGGRGSFGSLVVLERDVLSSAALGDMKNNLNGLSGDGYYIDVDIGSPPQRMQILIDTGSANFAVAAEQNAQITHYFHRDNSSTYREDGKDIYVPYTEGEWRGTLGTDIVSIPSAPNVSAEVNIACITSSKDFFIEKAQWQGILGLAYADLAQPDSSLVPFWDSLIEQNPELEDVFSMLLCGSSFVHTRDEPLMEGTLIFGGIDPSLSASPILYTPIYKTWYYEVVITDMAVDDVSLDMDCKEYNFDKTIVDSGTTTIRLPYAVFKALVAAIERTWEVKKINPWDLPGESFFSGEDILCFSDMEEPFELFPVVSFYLLQSENSSFRLDITAQHYLRPVQSVDGKGLVPDEMCVKFGFSPSTTGAVLGAVLMEAFYVVFDRNNSRVGFGQTTCPLPDPDHPIRNHSIVGPLYTKKDLRSCAYKKPDSHQSFLVVSYVMAGLAVVVVLPLLLLLILWVKNLLSRKRHHCADDDGSETRTVLSDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3D8</accession>
    <name>A0ABM0K3D8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acid phosphatase type 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101860122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107830.3">
        <property type="nucleotide sequence ID" value="XM_005107773.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860122"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="4">
        <location>
            <begin position="92"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="3">
        <location>
            <begin position="417"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107830.3"/>
        </source>
    </evidence>
    <sequence length="620" mass="68175" checksum="EECAF8D2E623193E" modified="2025-10-08" version="1">MIIIEMSNRSSSKKVESSRFSCKQVTVARNQKESNRMFPQSVSAVLIVTSLALSVVHTSEIPKGQIPDLDTAVAPGAGTARSVEDDEVWCMPEQVHLSLGNVTSEMVVMWATRGNCDSVVHYAAHPWNLDLTASGSCVELENVGNKSLKYLHRAVLKDLSPNLTYYYRPVVKNGVGSNSLLFKTSPSSSSWSSKFLVLSSTGSENDLMNSVTREVQSGQFASLLYNGELGPAERTEDWEGIDESEDFLTRAEQAVATLPVLIAPQSKDEGASGPDVNKHFSMPGWGWPQSVDRPWYSVDVGLVHLVSFSTDLIFAEDTTKATAQRDWLVRDLTEVNQRRNETPWVIALGSHPMYCSYGNPSSDDCAMNTSKVRHALEDMFYHFAVDLVLESGFPGYERGWPQYKGVLVDESYWQPRAPVEIVLGSRAGDGAGAQNKNNTVEWSALHLPEAGGHSFGRLTVANASHLLWELCEESKMAVLDSFWLVQSTHGNFSLANLPHNVSHQINQTIIAMGGKPGTYDFISGDKAGGAGEGWSQYSLWIGLGALSCVLLLVLGLVTLRSCLRRRRAKSGRRWREMDRNGGGAGNFYSVGSDSDTDDNDFEIDVYDKTNKQSSKLLTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3J0</accession>
    <name>A0ABM0K3J0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101862680</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101862680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005107926.1">
        <property type="nucleotide sequence ID" value="XM_005107869.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862680"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005107926.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="42520" checksum="16084FDF3F49C182" modified="2025-10-08" version="1">MNTSVSSFNKLQVPTGLLDAQAYELFSVIFLFALVIPITVFGLVSNVVNIVIFLKIGRDDPVSISFLALSVSDLTYLLILAFTSVSNGLVLYDVTGTTSLTPLVYYVIWYALIFHKTSALITTYTSVARCCCVVIALKFRHFFTLKRTYIVLVAIFLIGIGLHVPPIATQELTWSRYRVSRGINKSSVLVSGFTLKRLAGFRESKSVHDTLNNNALLYTCVAISFVCLLALVNALRASATFRQASTVVTSTSASSSSSSHDHTPRMTSPINTQTPPSSKLVQSEKEKTSHGALNGKEIQVIKAVTLVCAIFLLSNVPVILNSLARLAVPDFDLGRRFHYLFIVCSTTGTFCGYFSAAINIVVYFQFNSRYRDCLTSFISGKTGGSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3Y9</accession>
    <name>A0ABM0K3Y9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein Smaug homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMAUG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108204.2">
        <property type="nucleotide sequence ID" value="XM_005108147.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850204"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09557">
        <property type="entry name" value="SAM_Smaug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.170">
        <property type="entry name" value="Smaug, PHAT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037093">
        <property type="entry name" value="PHAT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037634">
        <property type="entry name" value="Smaug_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="171"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005108204.2"/>
        </source>
    </evidence>
    <sequence length="527" mass="57760" checksum="377D7BA932FF148C" modified="2025-10-08" version="1">MALRATNSHAGAFGASHGHIPLHATSSAPSNFNSMPPSGPIAPQGPSSQQQNTHAPLRRTHSITPPVRLQTSEKAVSDWLKTNHGHHHHLQQQQQQHLHHQPSQLQQLSLSSSSGSGGGGGHAHPILASRSQQYPDHAPLSPQSSVTSSGSGGSDGHQEDGPQPMRDSFLEEGSGMREVPVWLKTLRLHKYSYLFRQMTYEEMLSVTEDWLEQQNVTKGARHKIYVSISKLRERQDVLRSLEKNIVDEGGSINSALGKMKEMLNTPIKAFNPAQSSLTSNNPAYRTTSSSSSSSTTSSLPQSPSADEVLEGDLPAQFCRLMGKVCTQLLVASRPDDECFKIYLQLIDKCLNHEAFSDRQKKLLQSWKQSAQKIWQPSPQRYGDRPRRSFANTFHVGNSLGGRIIPRAGRIPVPQSVGHHQQHPSMQQWSFGSKRSILGGGSGGGHMPVQRNNSLNTAFLNKPGLLEQTKQPISRTHSAPTNRPMSLPMQGCENANDTEINARLDSLCISMTEHALGSSDTSDRGPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4K3</accession>
    <name>A0ABM0K4K3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-acyltransferase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101846249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108614.2">
        <property type="nucleotide sequence ID" value="XM_005108557.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846249"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047118685" evidence="3">
        <location>
            <begin position="25"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="153"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005108614.2"/>
        </source>
    </evidence>
    <sequence length="808" mass="91356" checksum="2D73DEE9F7031864" modified="2025-10-08" version="1">MFFVLKFLLVLFLSSFFLAEQVHGDRHHKEQKAKRTNNLYTEALSRLQYLRVLKQHPDYHNNLSTSLLSAVDQFHFSDFLSFIDSSANERKENEQSIQDSDHFGDQQTRRIVRRESSVKIKDALGDDATTDTGFRSNNGTEEKERGDVFRNDSAACFQDVARTIQAFNDGESWAVEMLDAWGKPGPSLKRGSFQFVGNYDQCRDARAPPLPGGERQGFYGRYCVLRLNYGQESPTPKQYLQIGSCIPDTCKEQELTQLVAKALEMVNMTSQLSPGPMECRDDHRGGSTFTTLAAIFFSIIGALMIAGTVVDVVFVQWPAWEAERVKSRGLPHEESTPFEGHEPIMLGQDKPGQEGRAGETTALLGRTLNYVPPSPLWEIILQVLRSFSVYSNALKILSTKEAPGAIGCIHGLRFFSMTWVTLLHLYMFIWGFLANPQRLLAMADRWTFDTVSNSAFSVDTFFTLGGFLVSYLKLKPWMEKGRSVNWRLFYFHRIWRLTPPYMLSLVFFTGFTKFFGSGATWPNTMPADEENCENYGWTNLLYVNNLVHNENLCMGQSWYLANDMQFYLVSPLLFVPLYYNMYAGLAVCGTVLLSSWIVTGVLSSDKDWIASEFAMTFTNPQLERFTDYYIAPYTRVGPFVIGILAGYLMARHGGQIAMKWYVVVIGWAVAVATGLAVIYGIHDDITAEDPSSTEVAALYNTMARSAWSVAISWVVIACASGYGGPVNWLLSWKPLIVLSRLSYLCYLIHPYIMYIYFGNHGDAFMFNDSNMIVSFVGLLGISCMCAFLLHLAVETPMVELEKTFLKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K507</accession>
    <name>A0ABM0K507_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101854754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005108913.1">
        <property type="nucleotide sequence ID" value="XM_005108856.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854754"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF67">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="791"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108913.1"/>
        </source>
    </evidence>
    <sequence length="1413" mass="160326" checksum="436D025C4D96EAB8" modified="2025-10-08" version="1">MAGLGTLILESENIAGCSSATVRDYVKRVLTSEIKDISRYALIPHMVVVTLENVVQDFGAAESAVSVCPLVGKSVCVRLAESGSALVVSGMEQFPLPWECLIDYLEVCFADGRHCVSYCTVWPDSDYALVDFLTDEWAVRKKVLDAVPHFPMGEENVGCRMSFEPYYINFHDVLFQDLGLGKEVPPYVEESGMVPSLVENVDPEKDVDGLSTHAPAPDACRAEWDGRGNDIYEDKGNDIQLDVLTWNEEVTVAHASTEENDQNDDDVHHQRVNVEHNDRDVHHQRVNVEHNDGDVHHVNVEHNDGDVHHQRANVAHEDGSHDVTSPHDHTSAVPSAVRGDTGQTWAVSVEGTSVRKETGDKRVPTSRPSTARSRKSSFSLGHFSREVTVVGIKTQQGNDGSLQRQTGLRSDTFQGCGRRGLLYRSLATPLDCRQLAEEQTSLERKLLAREKEKEQLNQIPECCNLSKEFALPKLHMKVLERKCKSTKECSMHFDSDNRKVVLVGTPEGVQKCERELDERKENIEERFVQLSPNMSQILRQEMGKAFLNEHLAELCWELREYALYVAEDDKHRLDAAVASLKDRLHHRLVEKYIGDIPGQTQNVIASQVQALFKLLVVVEPRHHSFIIEGVKDDVEMARIRLTDLLREHALFERTFEVEGEKAEYFDTFLRNQVMKVPSDVQAFEPVYDRGTFRVKYKGKLDNVRQVLQERRILEERVTVRKFSIGKEFSKRKEDVPLILAHLDDDDFRSILKTLERKHRSILKCEKKFQSQRLEENVEQAERKDAPALTGTSLVAQAGDNCEVLIKAHGNILKEQSDVLVCVEGENFDMSKTTVAQAFRKVSPLMEGELHSARNARDAASSDVIVTQNTCDDLPCRAVVHVALTRWNQDTSPRHFAQVLQQALRVSGTPEVTSIAFPPMGCGRAFSFPPAQEARIVLATMKEVLRGTDVKSLTRISLMASNRQLYSEYKRLITDFFPLKSTSHEENVKQERSNKENSWLFECTDGLTDAEITVLLQGQRSNVLVTHLKQKIQEIFLHVEQFNDKLMEDWPTCTLDNISAEASRAKVWLSRPSFKTSCFLLKGKKKSVTEVLVFIKAQSRRLAVHLPRRRIQDAPNRDTTEFVSYALSCDELFPSYWSLNSPAKVLEIKESYDPDLHEKIVDVDQQTFDCIAKLVADTWDATRFGIGSDAKRLKELNCSQLRVLKVQRIENPALFDRYHLHRIEILRRTEKNGQLYPKLESVSPFQTQPETMRLDQFLAKELLREINEHYFFHGTHAGTAGAVAKQGLDPRIANPGAMAGRGVYLAEKSTKSDQYADPRNQRTPLGTPLTLLLVRVALGNVFHVDRSHPSLQSRHGNKLLGPPCTNCQSDEPCNCKKPRYDSVLVEDTSFLFREFVVYDRAHCYPEYIVTYVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5B2</accession>
    <name>A0ABM0K5B2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101860366</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109098.1">
        <property type="nucleotide sequence ID" value="XM_005109041.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860366"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005109098.1"/>
        </source>
    </evidence>
    <sequence length="920" mass="96573" checksum="9F6E14CBA0B3B764" modified="2025-10-08" version="1">MDGVKTGQRLLLALTSGVGSDDLVGDTADVQPSFAPIIIAAASGICFVALVAMCVCGDSAKKKTEDGSLRQVMEEKPGSKSTGTHQQDGREPMAAPTSENGGPPSNRNSATMSGHSRQASSGSAHNLRPTSLRELPEPPVSSHHARNASQSGVVEVPSSSGHMVVGEDEANDPVAYGYHHYHEPNHHRANSSGGGMGIGIENNVGLRDRPGSINDGYDHLGAKPSVKPTDYDSLAAPRRTQAETPTSEAGPATDGHYSLLRERTYAVVKDVKAKASKLYDPYSLVKDEDEDSSQTGSNYYAQEDPYNHIGESDGAVSAALIRRIQQSGDADDPYATLGDEEGGDGKSGGSELQGAVGGAASHAVSPSTAATVTPLSQFSAHDSYSEVSDEYAVVQKSSRGTPSFVQEQENGTEDSLDIAPYSVGPPEPPRRYHLYEEEEGHFAESSAHPPKEHKYSKVTARESLASISARTALNPYEFVPDLPENTYATVEGGSGDGIVREVTLRGTGGAAAAAAASTETNRLSQNSDTYAEIAISGGGLSTSITSTGSSAGGGGGGGSNSLGSSSGAPVPPSLDSLHMMTKSQTSSEGDRLSDRLSDRHLASPEDSALGIFPWADELGTGSADSSEDGYSTLRRTEPYSASDTTLRGTAADSRVRDAESGEITLVPNYQKVKDCISDNEINEECENDPNYESVDEARSKVAALKASKEAAVVSSSHSKPTASPIHLVQFPPVENGVLTSMTPTLGHPSNGEFSISSTSTTSHGRQKRMDHDYEEVDLSPPTSPSQPGGPTPGLTPHLSPSTTPTGATSATSFVNSDPQASPQSVSEAKERLTHNHLYEELADVRLKKQGMTKINYEKSGKNVEERKKGSASNDKKKGEEKKKGGSEEKRKSGSEEKRKSGGGGDEKRKSGAAQPKNTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K748</accession>
    <name>A0ABM0K748_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-specific lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110322.1">
        <property type="nucleotide sequence ID" value="XM_005110265.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846171"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="3">
        <location>
            <begin position="275"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005110322.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="46628" checksum="295E125517FF1546" modified="2025-10-08" version="1">MNKMLSNRTYVIGVGMTRFFKPLTREWDYPDMARESGQAALADAGISYKDVQAVVASYCYGEPTSGQRAVYELGLTGVPVFNVNNNCSSGSTALMMARRLVMSGIEDCVLALGFEKMEGGLSEKYTDRTSPVKKHMDHMVDLGAKPGLISPNMNDMTSDVIKLFAYAAQEYMKKYPKGAQEALVQIAYKNRKQGVNNPRASFQKEMDMKTIATKAMLCPPITFGMTAATADGSAAVIVCSENFVKKHKLQDRAVEILAQNMVTDLPNSFERSFMDLSGYSMAREAAKKCFNETKLCPKDVDVFEVHDCFSCNELFMYEALGLCPEGTGVSLVENSEWKTNRNGGELLYLDKKWVVNPSGGLESKGHPIGASGLGQCAELVWQLRGEADKRQVEGAKVAMQHNFGIGGAAVVTMYGKADQKLLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7H4</accession>
    <name>A0ABM0K7H4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101851376 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110581.1">
        <property type="nucleotide sequence ID" value="XM_005110524.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851376"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="3">
        <location>
            <begin position="231"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005110581.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="34723" checksum="5799C4A54D9C07BB" modified="2025-10-08" version="1">MGVVDNIRPYAPGLRKFLLVILCLQSVAASLMVNSVVAISLLLTFTAFLVRIYRVDPEPVLLLMLHTVISGCMLYDVTSTLCVIVAGMTSLICLGGYEVHGERVAVLVISTLITAILGKPLAIIACVVVGVVIVVAKLRPLRPPMLLLVALSFIALTLLVNRAAGSVLVFVLMGIITALFVVNKVSSDDDLPPRTSTRSHHNSGNNNSNHSGQHSPVPNGYLQLSNPTESLDLHGHTVTGAMKVLHTFLRENEEAYKLNRTNHLRHVTIITGEGHHDDELGPAPLIKPTVLNFLKINKYKHSVSRETPGLIKVDLESHVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7N6</accession>
    <name>A0ABM0K7N6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864652 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110717.2">
        <property type="nucleotide sequence ID" value="XM_005110660.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864652"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110717.2"/>
        </source>
    </evidence>
    <sequence length="189" mass="21496" checksum="6C7FF74E79472D39" modified="2025-10-08" version="1">MGSIDFLKRCLLRCRSGDNDRHNNNNDNDGNIFVDVPSFGHTVKELFKFLEVRSYLYIAFRMFSSALRDVFLVDGFSTLPLIFVLYIILTTHACIIYTCNLNGRTAKADVAFIVMVILAEVLVAGCGLIFQSVDLLLELIAFAGLQVTVSIIYFLLMSPHMPRKLYRTFQRRRRCLEELVSPKRTSQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8F2</accession>
    <name>A0ABM0K8F2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101862912</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101862912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111264.3">
        <property type="nucleotide sequence ID" value="XM_005111207.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862912"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005111264.3"/>
        </source>
    </evidence>
    <sequence length="167" mass="19092" checksum="6E106345B4E795BE" modified="2025-10-08" version="1">MGRHSIVFLLATTAKDGCKVEHMPGKPTASFSNTLTYQDKETAIAVFSAVKETFVSFDNKTGSFIIKVTGIFLLHINMTIVDPSETHYAGLFLNDQAMFACQKGGFRCPRYNDDDIDSNMYRICNMDGTLELRLGDVLQLRTMEDNMTFRFERHRQSSFKFILLHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9P9</accession>
    <name>A0ABM0K9P9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Coiled-coil-helix-coiled-coil-helix domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8" type="primary">LOC101864498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112285.1">
        <property type="nucleotide sequence ID" value="XM_005112228.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005112286.1">
        <property type="nucleotide sequence ID" value="XM_005112229.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829311.1">
        <property type="nucleotide sequence ID" value="XM_035973418.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829312.1">
        <property type="nucleotide sequence ID" value="XM_035973419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864498"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033620">
        <property type="entry name" value="Ribosomal_mS37_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31278">
        <property type="entry name" value="CHCHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31278:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005112285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005112286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035829312.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16961" checksum="8A40A08255B81146" modified="2025-10-08" version="1">MRLTDAVFKTSSLKKFTNYKNPGYLHKVVRIPALKDQVKSRQLKSESAPCVNEMSRMMDCWKKSDFNQSACGKETQSFLQCMAAAEASQQQIRELAAKGMPMKGSRFRPSSQVNEMLAKYPQPESNLQGPAPRGRGRGMWGIPRKNYVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9Y1</accession>
    <name>A0ABM0K9Y1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">T-cell activation inhibitor, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112454.1">
        <property type="nucleotide sequence ID" value="XM_005112397.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845665"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027989">
        <property type="entry name" value="DUF4461"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596:SF1">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14688">
        <property type="entry name" value="DUF4461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="1">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4461" evidence="2">
        <location>
            <begin position="171"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112454.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="55277" checksum="3E8FB8F1A06D4918" modified="2025-10-08" version="1">MLRSLQSARCALCTQVFQRCLPLVRHKRYFTVQDASAALRPFYFVVHPDLFGQHPTERAVNENSLKLLNEYLAVHPSLGKTEPKEMVFYIRSQDSSGPGLKQVKICLTTSNLRDTVMAILSTCGLSNSHVPESSGIMYGTNRPIEWHHTYYTATGKKNPHSRKAEKAVALTLRSWLQLNIQRSRQHEESVRYIQDDIARLLDRLRRELCLKDIRFDSVWGFHHFRGCLKSFDRLYRDHPDFLKFVLKDRTLVFSNSTGVSRLGEIVLSSEDVPQTWFTLLRSVGAYEAVLHRLPTMEAKLSSLLNGIQVVRREKTHCSVMAEEYELLLNKLLNSLRRCQDHVTSTFQDQDLSGLQLVVEGEASPLMLSSLGQFLIPASVPGSLVVDCIKEHRAKAQQILVDIQGFLKEEEQSRLEAMDALGVSDMKKDESVTPAQMISCCKRLVEEHWRLGVSLADSRLRVSHYYSVMQDGQICIPWDWIGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB91</accession>
    <name>A0ABM0KB91_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone H3.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005113434.1">
        <property type="nucleotide sequence ID" value="XM_005113377.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860872"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005113434.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15709" checksum="70D0DE46FF14EBEA" modified="2025-10-08" version="1">MARTKQTARMSTGGKAPRKRLATKAARKSAPATGGVKKPHRYRPSTVALREIRRYPSFETRKLSFKHLVREIAKDFKTDLRFQSSAVMTLQKSCVMVLYEAYLVGLFEDISLCPFHAKHVTIMPKDIQLARCIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV57</accession>
    <name>A0ABM0ZV57_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Frizzled-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101849439</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935102.1">
        <property type="nucleotide sequence ID" value="XM_013079648.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849439"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15035">
        <property type="entry name" value="7tmF_FZD5_FZD8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07456">
        <property type="entry name" value="CRD_FZ5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045782457" evidence="12">
        <location>
            <begin position="40"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="13">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="288"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012935102.1"/>
        </source>
    </evidence>
    <sequence length="615" mass="68744" checksum="F1360BFEA3FE35FC" modified="2025-10-08" version="1">MPSASFTSSPVKMPSLGFIALAAIFTLLVVTSQPGGVSAGSGDQRKCEEVTIPMCKGIGYNLTYMPNQFNHHTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYAPICMENYKHHLPACRSVCERARAGCAPLMTQYGFAWPERMNCEDLPEFGAKDSLCMDANHTDRNTAPPPNPSYHRPTPPTPKSKPLPKGDGKVQSPGSRAPPTWGVGQIGGLPIPRRNPGEVRPVPGDVAEAPKEKKCVCQCEDPLVPITETSSSYFNKIRTGGIMNCAVNCYGPYFSEHERTFATFWVGLWSILCCISTSMTVSTFFVDMKRFKYPERPIIFLSACYFMVSVGYIIRLIVGHEAVACEGGKIRYDTTGPAVCTVVFLLVYFFGMASSIWWVILSFTWFLAAGLKWGQEAIASYSQYFHLAAWLIPSVKSIAVLAMSSVDGDPIAGICYVGNQSLDNLRGFVLAPLFVYLIIGTSFLLAGFVSLFRIRNVIKQQGRGKTDKLERLMIRIGVFSVLYTVPATIVIACYFYEQHLRERWEKTHTCSCYEEPAVPDYTVFMLKYFMCLVIGTTSGFWIWSSKTVESWRKLFHGKLCHKSSYQNRKYSSTAYHQPAKPHPLSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVM9</accession>
    <name>A0ABM0ZVM9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101863731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935484.1">
        <property type="nucleotide sequence ID" value="XM_013080030.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863731"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NXPE C-terminal" evidence="1">
        <location>
            <begin position="63"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935484.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33213" checksum="9AD31F5F095E8340" modified="2025-10-08" version="1">MAELDRTHKKPRIRLIGSLIKLTVTAGKPPGAFTLPTIPCHKIQPNQTWTRQSPNGFLFNDKWNFLSCQRARSRNCFQNLTLYVLGDSNSRHHYNSWCKLINAVQRIKQTIPAWHSPLECSKPSINFFSRWDPHASPFTVSMGVWTLLGTQIIPSSHVIDSIPAKTPGRVLLVLHHYFHLTMHHVTAFHNMVIASRDAVARLLDRNPNVQVLVQGPHVTYVGWDKHYVAGDGLARFMEELLVQEYRPLRDRVIYLRTWDLTLASENFPYHPRLQRTIDDLILDLMCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY06</accession>
    <name>A0ABM0ZY06_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apolipoprotein D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936820.1">
        <property type="nucleotide sequence ID" value="XM_013081366.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011480"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003057">
        <property type="entry name" value="Invtbrt_color"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01273">
        <property type="entry name" value="INVTBRTCOLOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046964304" evidence="2">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012936820.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25094" checksum="ABF9B9AD2B1A43C3" modified="2025-10-08" version="1">MTRRTRVMPGCQVFLIFAFFLSVDISLCDVVIGVGPCPTPDPKQDFNRTEFLGDWYEYERFPNKAEKHLVCVGNAFTDTGDEKMHLIQSAMREVREFGEVVFRYPVITSATASPLNEEEPARLRISYTPALERPPLDLYVVETDYTVYALLFSCTEISEFINIQRAWILTRIAGMPPLNILALKSYLVRYAVEVKYFQSSHQEYCRHDVPMNMKLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYI3</accession>
    <name>A0ABM0ZYI3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Involucrin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937167.1">
        <property type="nucleotide sequence ID" value="XM_013081713.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011584"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937167.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="38453" checksum="E3D4DB2F784E0C62" modified="2025-10-08" version="1">MMQRMMQRMMMVMMRMTMMETINESEDPHQEKDIHQNLEHKRNQHQDLTIQDQHRDPTPQKPHQDLSTQNQHPNPAIQDPILQEQLQDPTLQKQLQDPIIQGPTPQEQLQDLTLQKQLQDLINRGPILQKQLQDPILQDLTLQKQLQDLINRGPILQKQLQDPTPQEQLQDLTLQKQLQDLIIRGPILQKQLQDPILQEQLQDPTLQKQLQDPIIQGPTPQEQLQDLTLQKQLQDLINRGPILQKQLQDPTPQEQLQDLTLQKQLQDLIIRGPILQKQLQDPILQEQLQDPTLQKQLQGLIIQNKLQNLNIQDQLPDPMQQPKDPDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0C6</accession>
    <name>A0ABM1A0C6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011814</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938241.1">
        <property type="nucleotide sequence ID" value="XM_013082787.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011814"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012938241.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25275" checksum="2993D7AD8A9E7F74" modified="2025-10-08" version="1">MLSSKPATASGNKPLLTPEEKLRSAYVTLFREMQFRSTKNALMNYYQAEALDQQGRQIKILANVLTGLSTSGILASAVQKGKMLASKVGLCGLVSLPICAAVQVFTSSTSEFLPSHQERAKKHVSAAAAWNRISERSRAARLRILADPKCNMEKYVSLHEELLLEKENVSKTVVIPKEIHYEFNADIDKVYTTIRRRKEVFKQFQKFQLIDEKEDEDLDIYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A126</accession>
    <name>A0ABM1A126_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium/calcium exchanger 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101861699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012938666.1">
        <property type="nucleotide sequence ID" value="XM_013083212.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861699"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF70">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="48"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012938666.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34580" checksum="4C6B0BE11A3EC12A" modified="2025-10-08" version="1">MAYTHFTYYTNGFVAEYVDAGEERCSSWLLVPAENLWPDWLRGILYCIALFYLFVGIAIASDIFMCSIEVITAKQRKISKWDPEKNEMVEKEVLIWNETVANLTLMALGSSAPEILLAVIESGSNLTSTEPEDSLGVFTIIGSAAFNLLIITAVCIVSVPAPQSKSIKEFGVFIVTGVWSIWAYIWMLMVVKYITPGVIDPWEAWVTLLFLPVLVIMAYLQDLGWCCSRKKVGESADGEDPTANVRVGTVHPHPQLTGHTHKELHVLEAQKAHRMSIISLQGLERPRKSIAADSMTLYGYRNHRYSITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A132</accession>
    <name>A0ABM1A132_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase II degradation factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938677.1">
        <property type="nucleotide sequence ID" value="XM_013083223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011937"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938677.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="16785" checksum="04CA34FA51A2C9B7" modified="2025-10-08" version="1">MPGTSGPLHPLHGINLPFASRHTGSGAGMTGGADSSKKGSNSSEKSTKTSISSKSLPNQPQQRYQYLSYQPQPQLLLQQPQILQQQQQQKQGQQHDKGGGLLTARKQNNNAGRMFLGNNEVAHQGKGQGQGQEEPDAGTKLWKNTAALDEARSTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1A9</accession>
    <name>A0ABM1A1A9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibrinogen C domain-containing protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938811.1">
        <property type="nucleotide sequence ID" value="XM_013083357.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846430"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046489705" evidence="2">
        <location>
            <begin position="23"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="407"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938811.1"/>
        </source>
    </evidence>
    <sequence length="617" mass="71149" checksum="A4C017B7228E3400" modified="2025-10-08" version="1">MDANWVSLKLILATALFLSSSASVLNVTTPEVEVGKTANVSLECFDPYHARDISDIIIIRILKWDHDEWNSVAELQRGEDAEVRQNSKDVFVEGRIGSVAESFLRLTFPVATNNTIGQYRCDFISFTFQENVMWQKSQPVFVTRKRILTVQMLREIVEENQKEGFQQLHSQRQDLIENITATAEVLEAGLESQLKNQLQVLRHTVEGNKNKSDNQRQNILEKIKTSVKDLEAGFERKLKSQIQVLSHALEKNENECKKQKQSILEKMATIVEDVESKLKSQIQGLNYTFEEKKKEDLQQRQIVEKVQTSLEDNKREYLQQKQDILENVTATVEALERKLNTTTNSQQRVLRLTFEEKKKEDLQQRQIVEKVQTSLEDNMRECLQQKQDILENMTATVEALERRLNTMVSQLRPQSCADVEGLGVRPVVFLNNGLRVVCDTVTDNGGWIVIQRRASADVDFYRGWTEYKNGFGNLDGNFWFGLEKIHQLTKKERYQLRIDMKFKGKDYFATYDSFSLSGETENYKIQISRFSGNVDNVMAFHNGRMFSTKDRDNDGHSKICASEKHGAWWYSSSACHRVNLNGAWGSTEYDKGLNWGDVTGWKDSVTFSEMKIRPLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1C8</accession>
    <name>A0ABM1A1C8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline-rich extensin-like protein EPR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938843.1">
        <property type="nucleotide sequence ID" value="XM_013083389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851870"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047120451" evidence="2">
        <location>
            <begin position="25"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="3">
        <location>
            <begin position="60"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938843.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="58935" checksum="F9343C750030FC2F" modified="2025-10-08" version="1">MVQDAATRALLLWALVSLPELCQGHGYLMDPPARASMWRENFKTPINYDDNRLNCGGYYTVTMKVMITANHLGWFEFRLCPHNSPSTPVTQDCLDRHLLQLADGSGTRFDLGTKISAVPVEVKLPAGVTCSQCVLQWKWHVGNSYGQDGQGNGCKGCGPQEEFYGCSDISITTGGGGVNPTSGPITNAPVTNPPFTFQPVTYRPVTSVPVSTQRPVYPTFQPVTFQPFTNPPPQTQKPVYPTFQQITFKPYTNSPPKTQPPVYPTFQPITSRPYTNAPPQTQPPVYPTFQPITFQPYTQSPYQPVTNAPYQPPVTAKPNPRPTGYVPMSPAASMKPGTPQYVFTTRPTNPPVTFYRPPSTRPPPATPRPTIYRPLPTIKPQPVFTFRPTFAPLITLTSAPFTYRPNVFPLGGRTTQPPRTTRPPPVTFYRPPSTARPLPPFQPITASQPTRAPFTLKPTVFQLGGGTTKPRTNQPLNTMYPGRVTPPPATARPMTGPYCYAINVQGGNTKLDQWCNAQCTRLGGSCPPEYCECKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3E6</accession>
    <name>A0ABM1A3E6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetylcholine receptor subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940025.1">
        <property type="nucleotide sequence ID" value="XM_013084571.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849549"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="16"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="188"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012940025.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45520" checksum="D9596EA1426C2D77" modified="2025-10-08" version="1">MHVLHAVRRTYERSRMITNVDEVDQIISILSYGEISWRDTSLAWNVSEYEGIDFVKLPYDSLWHPDFIVANAVNSDFITTDSYVSLFLYHTGRITVHKPMHLRTLCSFDLTYYPFDTQSCDIVFYPFFDDVGLVFEHISLHPMENPFTQSGQWSIRDRKMTPGSYHAGPIIICNVILARSQLYYIMCLIVPMLITSAMTSLVFWIPVEAGEKLSFLVSVFVSNAVFLNFIANTLPKNLNAMPRLALFLLAVNGDCLFAMIATVFIMQKHQQEQKAATMTSRDEERRSRLHHAALDVDAVTNLNQKGEEKVLRENSESGNVILQKELSDADLCRRLKRAVGKAWQSKVTDSSLPAEEDNSKAKAKTSRWHFSAKAWDRIFFVTFHVISIPFYALIFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4K3</accession>
    <name>A0ABM1A4K3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC43 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940724.1">
        <property type="nucleotide sequence ID" value="XM_013085270.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847744"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058771">
        <property type="entry name" value="PWI_CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26091">
        <property type="entry name" value="PWI_CCDC43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC43 PWI-like" evidence="5">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012940724.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24727" checksum="EC6459E070FCDEDA" modified="2025-10-08" version="1">MATSLVGPYDVWLTETLTAASADIDTDVFVSYIIGILDDDTPEEDKKEGITELLSGVVEPDAASQLYESIVAKWAEQNESRTTPESADKGDQLSTFLGQQTLATVKEKKLTKEEAERKAAILAQYAQVSDGEESEDEGDDSDGSPATGGGGGGKGRGETQDSLLMRNVNKEEVARAEKDLREKAREEVEKKKEKDKQDRAAQKQKQQERKDTEKKRTQKGEKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4Q1</accession>
    <name>A0ABM1A4Q1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBL-interacting protein kinase 24-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940793.1">
        <property type="nucleotide sequence ID" value="XM_013085339.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853180"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940793.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31228" checksum="62C98E3031518FC9" modified="2025-10-08" version="1">MSSVEQISVIQLPKEVDVFHYHRMQYSSVLHQGQRSKILLARSQIIPDKKFAVKQMPLRSDEDRDRFIREMWLMKLASDIRGVVTLLPRPVFCGPTGYLIMPFYDKRDLLSRTGKLSDDNWMKVFVRAAVSLRSLHKKNIYHQNLRPENILLSTRHVAFISDFGAACLLSEGCDKVDTWTAAPGFRGPEADKEDGQLCPFQLDTYSLAVSMWQVLSGLCPVKNKPLDHLDNIPPQYASLLRNLLLPDPDMRWTLDKFLTEALELHPDLSCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5X5</accession>
    <name>A0ABM1A5X5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012595</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941451.1">
        <property type="nucleotide sequence ID" value="XM_013085997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012595"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941451.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17814" checksum="39B0CBD8D84A35D1" modified="2025-10-08" version="1">MVDFNESLAKGKIPEEWLHSYLMPLPKLGKDHSNIKGYRIITMQNTYGKILEKTVDKRLANYQEKKKLLPDGLGSYIPGKDTCTNTDVLAFDAFEGFQRKEETTMAAIDLDDACNRVDYGMLMDLLIEMDVDPWLVQWISETLFERKVALRSGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5X6</accession>
    <name>A0ABM1A5X6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transforming acidic coiled-coil-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101855124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941453.1">
        <property type="nucleotide sequence ID" value="XM_013085999.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855124"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="1213"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="736"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="790"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="863"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="903"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012941453.1"/>
        </source>
    </evidence>
    <sequence length="1410" mass="154126" checksum="2B181FE0A4BD6B53" modified="2025-10-08" version="1">MEIPTDENALENLPKVYSLERASNPCKSPLKPVNDERRLTGTPRTQEKDNKTPTSSPFTYIRQLDSAERWIERTSIVTKQDHALNLEHAKDILDTLISSLPVYEQANKWLSDAAVNGDSPRPRPVDKPAAQQTASAVDELASLFGELDITPKSVESPQAGTTQTEVVNQNVLPGANLGTAQTTQLEADDSFHSALDEDDDALQLQEENCEPEQAHSSPAEMSVESGQDPFKCSKQLMNSPTVTPLSVSDSFRPSEANSLEAKPTETENSSEHEKEEDSTSAHSSPDADNEIQITPVNERTESSEISKPHKEAIDSSIHPQITPECAEIATENSEVFTDNPFQCRKQLQNSPVLSKSASPDNVALVQDSVLNTSSDGVLKVPFEPESESVISPSALVLENIRDVCGEDTADLTVDPFKPSHQVANSPAVCDRQTGSLEQEELHGQVLGVDRLQTTSAAESTHDEVKEETISPPTLAPETESSGKVETASGLDINPFETKSQVANSLIFNKATEDGNGIECDSSSLSSTTLINETNLADQEETLLDVNPFETKTQLANSPVPGETLKDNDGKESYASSHFSTMECSKTESPAQETVQGLDVNPFETKSQLANSPIPSKISGGGDEKEVDADPFKPRFQVANSPVLQETSTDSSTPQDAGVAEANTDTEISLQQSSHNSNLSPPEKDKKMETDVISIPACPESTKGSQCSDNILDTPEPSHLPKAVTAEDLVPVVEMDTTGAHVNLSHPEKEQTTSPVVQTLSSDSDESAITTEKNDAAMAEEMEDTSDPFKPSSQLTNSHHVADTSQVFSLPSSDADVSTCQPEDDPFKSKSQLPNSPQLVDDNPFKTKRQIPNSPVQCDDNPFKTKSQLANSPPQTVVESQENQTDVSASSDSAPATSVSEHVPPQKEESMDVSKKENPGNVSVDKIHHLDKAPSTPLSHGSTASTLRPPVSLQFDSNLDERSEDVGPTENAYGATEGSGELDAITGANAQNEPKGDGMPKKEDEELFVPATQAFADPAFLDQLEKAHSSSSVDVKRGSVLLKFDPLQEHRLEVSFAKPSSPGQVQKGTRVSDIFKKQNKSGFLSSSDESVCLFGTPPKVSRRRTLTRQMHSTCQLSIEEETPANQVDMYFDMDNDGDGMASILSDNLLPEESKEGKLVDVVEMPKYTESDLKNIRSNLTLQYQELMLKKDREFQERLKEQQEKNAARLADVEKEKTSLLATAEEEKAKLKEAMDSLTKKNKAQKQSLGNSQKLMNEFDEIIKQLTKDKEELNVQLSQATKQGELYLQDNKELEKSFDDLLHRYDKLKATLEKAAKNEKVLTQAVQGAQEKFKSVQETSKKIKDTAKTKLSEQEEKYNKLETSSKAEITRLEAALKRKEMDVTRLESTLQQKVAENKELTDLCDSLISKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6A1</accession>
    <name>A0ABM1A6A1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101860516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012941633.1">
        <property type="nucleotide sequence ID" value="XM_013086179.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860516"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16521">
        <property type="entry name" value="RING-HC_MKRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="245"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012941633.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="50856" checksum="767A7716547965B3" modified="2025-10-08" version="1">MATGGFDPRMSGGRQIRLQVCRYFLHGACNRGDSCRFSHDKSRAVPVDNICRYYLAGNCVYGDRCRYDHVKTAVPSASELSTTSKKAENERNVPQLQSNMVKLKKGGLEQSLAHAKHEQEKELFEKKWVEAKDFVPGQKFHGSVPGSYAQAAHSDVDQAVGGFDPGKPPKEVTEEDLLCPYFAHGHCSFENCAYLHGEVCDMCGLPRLHPTNKDLRESHQKECLEEHRKEMELAFLMKDSSEKECGICLEVTTEKVGENGAPVDRRFGLLENCAHCFCLTCIKEWRKERYAEKETHRSCPICRTHSNFVTPSEFWVDSEEKKKELIADYLAEISKKPCQYFKQGKGECPFYDKCFYLHALPDGSIAPPQARPKRRRRVDADGEDHVEEYSLWDFFASRDDDSLISLDDELSLILLDVLHSDDEEERFGVRFNLENGDFVFTDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6G7</accession>
    <name>A0ABM1A6G7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012666</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941738.1">
        <property type="nucleotide sequence ID" value="XM_013086284.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012666"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012941738.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40173" checksum="575DC0945E3E313E" modified="2025-10-08" version="1">MPPSHVIMSRYVIGYKRSLTLLLLLCGGLAMYLTAFSTHKDTREYVPLFQGHPGYDITLVTMYLNLGKFQKGGGNHFYTTEGYLGWMKSWGWLNNTVVAFFDDDKILEVFRKIRSAQPPERTIIHKISRDELPAFKDFDKIKKMFAQPSYPKHYPNTVKAEYSCAVSAKTDVLDKVLTSEKINTKYLAWLDIGYFRLLTYPKFYPANKTYKLEVPEGFKDDTVAFSVVNDHGNALEQKPWDIIRHNMVWVASGLIVGTPKVMQHYVKDFRAARSELLAQNMMSTGQQILASLYSKKMKTQPSIGYSLYSCTEGQFGMYASDRIYFCFGFKCKEAAEIRSGGKNGTVTGTKIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6N5</accession>
    <name>A0ABM1A6N5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inter-alpha-trypsin inhibitor heavy chain H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941862.1">
        <property type="nucleotide sequence ID" value="XM_013086408.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849075"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050934">
        <property type="entry name" value="ITIH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338:SF108">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046257575" evidence="1">
        <location>
            <begin position="24"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941862.1"/>
        </source>
    </evidence>
    <sequence length="675" mass="76403" checksum="B890E7C2D8EE85CF" modified="2025-10-08" version="1">MGTMSKVTLCVLVICSLARVSESQAECVKYNVRTNIRYHLATSTVSTELYNLANTPTPSYVNFTVPLPLDAQISSLSVQCDGVLYETTVVLETNEPGPPQLDFDIHDQVDLGVQVLSIACLSKPQSFAELNVTYIQLLQRRLGAYEHVIHLDPSHVTTGEVLTDINVEEIGPLQAVKYNYGNGIDRRIRRPTLRTAWTQRAVSVVRAEGAWSDVVTPAKLVFRYDVKSTSLGGDILVSGGHFVHYFNPEVKHELPTDILVVAETRFAPHDPPFLDIIQRGLKQVLRQMDKDIQGMDRDFPEGACTVACEKHSSLGLAQTPSEVCDLCCETNNTETILNYDPSECDLKCKVGWKDDVGERKLETTNDCQVCCPLKHPNRFDIQQLGDKDNHRHSFEYMDPITTYNIDEAIRFVNSLEGAGYANIYQGFKEAFKHIRLNGRRNLGRSIILALTDCLQAGRRELEVPYAIARRNHLKTPMYVMGVSQDTQWHLAQRYSLIFGGKAQRLAYNRNDTTRQIRDFYREHAHILLSHVHFNYSQAEVDDFSLTSTFFRNFFKGSDVILAGKLIDNSIQTVEAFMESKGVKMVKRRMTTSWVTAEAQPLTFELPVESRDVTEKIWALQRLHFCWDGMAELGTPFPGREDPTDVEIEYLEEAEDISVKYGLLTPLTTLEFKVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A761</accession>
    <name>A0ABM1A761_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101864544</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_012942167.1">
        <property type="nucleotide sequence ID" value="XM_013086713.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864544"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF126">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012942167.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="37002" checksum="CDB74258327C363E" modified="2025-10-08" version="1">MEYFNISVESAVSLYDDLMDKGDPRTEDWLFISTPLPAITMMLTYILVSLIGPHVMKDRKPLNLGHLLTAYNFLLVGMSSYMTYEFFMSAYLAGYSVGCQNVDYSNSPLALRMASVCWVYYISKYIETADTVFFILRKKFNQITFLHVFHHSTMIVNWWLCVKYIAGGPTFFHALINSFVHVVMYSYYGLSALGPAVQPYLWWKKYVTVIQVVQFTAVVIHSVHFVFRCDFPLGLSLLSLLYAVIMISLFLNYYHKEHVVRAKARQLRKQKLEQELQQGTQAKGITRQDGNGHSVTSSDRIATNGNLHGSNEVTRRKVRDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7V0</accession>
    <name>A0ABM1A7V0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Leucine-rich repeats and immunoglobulin-like domains protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942522.1">
        <property type="nucleotide sequence ID" value="XM_013087068.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850985"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF21">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046492119" evidence="7">
        <location>
            <begin position="26"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="509"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="610"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="704"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="852"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="943"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1126"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1316"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1415"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="961"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1021"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1166"/>
        </location>
    </feature>
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        <location>
            <begin position="1187"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1331"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1455"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012942522.1"/>
        </source>
    </evidence>
    <sequence length="1496" mass="162902" checksum="D2F326E868CA8C61" modified="2025-10-08" version="1">MAAVLLSVCSAFVVWVCCSVQPVVAESVRCPSSCACLGNNVDCSNIGLINIPKDIPVWATRLELQSNGITEIRQDDLKGLPNLQYLDLSSNDIKVINGSVFRDLTGLLTLKLDSNELTEIPQFPIPLNITELSITQNHVVKIPLTAMSRMPELLTLDLSNNYILSIENGSFHVGSKLTHLNMNGNQIAALDIGCMSNLTFLETLKMNKNKVMELPQEVFSGLSSLKTLELMRNKIKVIKGLTFQGLKELQSLKLKRNSISVLKDGAFWGLSNIVNLHMDHNDITNITKGWLFGLKTLKHLSLGHNKISKIEGDAWEPCKHLEKLDLAHNRLTALTEHTLTHLASLKHLFLDHNQISRIDEGAFRDLPELNVLELNANEISWTMEDVSGAFRGLTSLTTLGLRANAVRSIAVHAFSGLPRLRHLHLEDNDITSIQENAFETLRDLRDLQFNSSKLFCDCHLSWLPPWLKQNGFQHSAIGVCFYPQLLRGAALSQIDVADFKCNNAEFPKPVILESPKSANGSKGENMTLNCVTAITGDSQLSILWKKDNVMLDEMLSEVTATSDGEVKRFTSHLHLRDIEDSMAGRYQCVVSNEFGKVFSQRAYVKVYVYPMFLKRPKDVTVKAGKPAELKCAATGQPAPVISWQKDGGDNFPAARERRMRVYPNDDRFYILNTRVADEGIYSCMARNDAGVVITNATVTVLETPDFVQPMQVKKSTKRGETTVLQCMASGSPQPKLTWLKDDKELVMTPRHFFTVDNQLLVIVDTQWSDAGIYACRMSNSLGTAKGATELQVLSTSGEVHEPGGSSFGLDDESTTTGIIIIAVVCCVVGTSLVWVIIIYQTRKRHEVYSATPTDETTLPGEVPSSGYMSSDKEGSYSQGPITMGGYHYQDYQMKESGYESSSGQFRANGYARPAVCPSDVDEDDNHPPTLTAGDRLLRKMNSAHSAASLQYPGSDGDTIGSRHSTSSGQHSGSSDPPSSHSGHSVSPLVVATAPACDDYWRNPSPAFPSPGSDEPRDFSESHASQLHQPQLLSPEGRPLLQTFHPTKMSHHEKLGTANTLGNKAGVGWSRGGSRGGLEGGGRCGGVYSRQRHHSDSCDNRDIESPSPPLPHCAGCGHHAWPASTTGANSNSMHGHPNGRTEIHHPSSNHIPCRMHDVDAVNSDKSDSVGAGSKRQPRSDSKPPVNPSSAISSSSQGSERKGRSPPTYSEVCGIKGNPAKGHHPQSSRSGEGLDNRDNSAVHARLHHYHDSGGMHCSECDNVYPLPSKHATPSSSSPRVATPTPCCCEVMRDPHYCPSPHHPPQHSSRCCEKNMELQGRRSGPHRGPVSMPPHRHKGGGKKVPVKIERSRSSSSVGQEPLCYAQCDTYSSAAQPDCVSCSCNAEHSSFSTSPMFQCAHCPDCQSQRDVEQLNAAYSRPHRKGTPSSSSHSHNVSCGSTSNGHQSPSSVAPPPSSHTPPLHSSIPAHSNSTSTPLPSSSSSSPSLQQQPQHKTGSDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7X3</accession>
    <name>A0ABM1A7X3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101846160</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942549.2">
        <property type="nucleotide sequence ID" value="XM_013087095.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846160"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942549.2"/>
        </source>
    </evidence>
    <sequence length="432" mass="47796" checksum="E310247DF905E6B4" modified="2025-10-08" version="1">MNRLPVTAIDSDDSASDWDSTVAEAPPQSPQASAPVVETEGEYATVTPRPRTSLQGPAAGVASSKGVINGQLTAPSPRRDTSESSAVSDVPSPPPHMTSFQNSLNDYSVVADPAPEIPSRRYTTKGMLYTVPETEGYPTPQPPVAVNWDDSDAEEQVLKELQQNLERDRQRQQAGGERKITLSEASLSNGNENRGYSPSPTVTRAGETTLERWTRTKDGGKREKSPESLHKPDRRSDVVSKSAVELDIGYLRSPGVGGEGGRGQTVFLQDSTGKKCVFFFEEGSLHFLKVEDDEVNAYLPDKVDKLDKVFRRIWREGFSVLRIFTSFFVLMVLELVLYLMKHVLRPLVVDVLGTVGDHFLKPLFTVTFNAIIQPVAAFHWNIFSALYHAFGPFVKFLGAILSLVAIPLRAFRLFVFNWHNPPSRHKGEVDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9D3</accession>
    <name>A0ABM1A9D3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101859887</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943332.1">
        <property type="nucleotide sequence ID" value="XM_013087878.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859887"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="5">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="607"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="735"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1275"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1339"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1378"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="828"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1294"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1305"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1346"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1390"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012943332.1"/>
        </source>
    </evidence>
    <sequence length="1399" mass="156264" checksum="EB06519B99E7A83A" modified="2025-10-08" version="1">MDEATSLLSRGDDTSKPSSPPPRRESFHLSQELKILEEEKEAKKEDDNRRKGEEVKGKEKDDEMEEVLEDVDERQKGGRKEQYDQSKEKVVSGVSEDRLQPEDFEEDPTDLYYASLNEGELLGLNSELASERTALLLERGRQNRLAMSVTDQVNLEAQELLRLFGIPYVVGPMEAEAQCAYLDITGQTDGTITDDSDIWLFGGRRMYKNFFNQNKHVEFYSFDRISNHFGIGRDQLINIALLCGSDYTEGIQGVGPVRALEIMAEFPGTGSEGLRAFRTWWEKMKKREQVVGSKTRARLKNLKLPNGFPSETVVRAYLSPTVDESTESFAWKMPELDVLRDFAKLRFGWSREKSDQSLVPMMKQLTQRKNQGRIHAYFQPESFVQSAKIRSDRLKKALSLVKNSQGGDEEREEEEDEMSGDIETKRMRKAQGGKGRVVGESGKGSEKRKKQGGKGRHEEEEEEDGDDSDVSFGYNAKTESAIKNSCLDLMVGGTVSDEVWPDHEQSSAFQVNTKNVFCHGDISRSTQSPVASSQLGVQQIKGDKQGPDCANGNYGVTRSCPKTELPLVAQCSNPDLPELWPEAGSVTLKDNTSPAGCNIFADRSRKSNINGTAKGAPPSSAPNAPRGGPTPSSAPRGTSTTSSQKEIVRLESLCEARTKELSQARMQLRATTQAFDAMSVVVNYCCVELDAFECPTLALKLETVQRQLKDCLTQIADLTSEKDALDKNLSEISQQKEEASKLEQEARHKAQADREDHEKVQKDMEDTHNAALTAQRDELTQQHNEAVKKLHDFHDKQIDLQKQAFDRQLLDVKNENKMEINGIRISQLEEIQELRNKHDTQMEELHKQHRNKLEDITHRFESIKLTLSEKVESLRGECDDLRHRARSSEEALQRDADVKVQMALAPFLSLPKEIESLKTVVEMRNEEISKLRSRNMDLEKQLEEIPIARDKIISLQQKVENLEAIINIKTDHEKQLHEKCQILMRKYDKESRANKRLSMDYEQVMWRMSQSSEFGSSESLSKRQVSRSPARSETTSPDPRHRTLSPNYHGPNGDVVMRVKKRSSKSLCETDRKLRSRSATFVVEKDEKLVESRSPSSSPQVKQKRWKRISQGEEDASENSSDNLDAANERARMCVSAGPEILSQYTSGHLGDGDVCEESDMPSLGNTMDSNLASSGEMINSYARSISGVSDSGVYDSMTRSEMLNSSIVSTDSEWVASANVSQMLDSTNEDFDGSPDGCSEQDRTVVHNVRSYSRSRGDSDTEGSARHTYQFQVSIPGSTGEPSADNVFEDQESGSLGSCSLSLENTTDGAPSVSNSRLTSVSEDFSCHDIACDTTVSLPLGGAAQDDRTPSRDVSSDNLSGLPRSETVVEKCIGEMGGAQCNSSGEGRATQDDVHQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9Q4</accession>
    <name>A0ABM1A9Q4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106013131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943518.1">
        <property type="nucleotide sequence ID" value="XM_013088064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013131"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046099086" evidence="2">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943518.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17560" checksum="03BF36EAF5A02EC5" modified="2025-10-08" version="1">MKTRSLLPVVLCVGVCAYLVSQVTGVPVLGFCPRPVTKPFFVPLKKRRCVGEPYSVTGIARRNIWSGDFRIRIQNIFFQLRNFRVIDTDYVSWALVFICDPVLFFLPISRQTAMILTRRRGYIPPKRDLLKIKLFLNGINANWLRPVDQNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC89</accession>
    <name>A0ABM1AC89_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">ATP-dependent DNA/RNA helicase DHX36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101845366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944942.1">
        <property type="nucleotide sequence ID" value="XM_013089488.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944943.1">
        <property type="nucleotide sequence ID" value="XM_013089489.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845366"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF237">
        <property type="entry name" value="ATP-DEPENDENT DNA_RNA HELICASE DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="396"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="645"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012944942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012944943.1"/>
        </source>
    </evidence>
    <sequence length="1178" mass="131843" checksum="EDE4D074FE4D8A7D" modified="2025-10-08" version="1">MSYGGRGGHWGGRGNARRGAYGNNWQQSQQGWSNNQGQGFGAPSYGQGNWSQGGQGGADGQGLMGPVPTGNAYQGYGGGQGNTFQSYGGGGRGRGRGRRDRRETHRCELPPDSSMDGSEEGGEGSQSGGRERPPPGLRGRDIGMWYAKRSQARKEREQKQNRPTVSMDRRQEHQIRQLLTDLKDSDDTPPATSHSGMSASSSATTPMHLPGGGKSRKLQSDRGFDEEEDQTAKRPSSGAGAAWDSTGQQGKSQTRFVYQDKQTDMFPESSEPPDNWEVLAGEEETEEKKGDGSFFVEVVPPGGASNLPLKEEEDMEEEEVPSVAGVVQYLRSHGDYPYASEEPEADFASSVPQSENPTLDKEMQETSRKLLNNPQFTKMLEFRHKLPSYEMKETLVSAVQENQVLVVSGETGCGKTTQVPQFILDDYIERGLGSQCRLICTQPRRISAISVAERVAAERCDRVNDSQQSSVGYQIRLEAKRPRSQGSILFCTTGIVLKFLESDPKLQRATHVIIDEIHERDLQSDFLMIILKDLLAVRRDLKVILMSATLNAEMFSHYFNDCPMLNIPGYTFPVKEYLLENIIEMTGYRLREGNTGFRGRKRDTQKDREERENYMVWLRTLIGRYDMKTIEVLNKFDYSCIDLDLIQHIIHYICTQMEDGAILVFVPGWEEIKKLNEMIQKTAQSRSGSLRVIPLHSLMPTVNQREIFDRPPPGVRKIVIATNIAETSITIDDVVFVIDCGKIKVKDFNPDMNLTSLEPQWVSKANAKQRRGRAGRVQPGHCFHLYTEFRYQLCRDYLPPEMLRTRLEELCLQIKLLKLGRIVPFIGKAMQHPSMEAITHAVDTLRELNALDHDENLLPLGYHLARMPVEPHTGKMILFGAMFCCLDPILTVAASLSFKDAFTVPLGKEAEADKARKRLARGSKSDHIMLINAFSGWEENQKRGQSGQFCWENFLSDNTLRMLRDMKKQLAELLHDTGFVASRNPKDGPANINSDKSSLIRAVLCAGLYPNVAQVTKVHKPGHKRPGGVAMTMKDDSRVAVHPKSVNSEESFFESKWMVFYYKLKTTKVYIHDCTMVSPYPLLFFGGEIKILRDQGTELVSVDDWVIFKASASTAQVVKELRQQLDKLLTRKITRPGPTSWDNSTSEGPLMAAIADLLCTEEAGQSMGGSIGYPPEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACF6</accession>
    <name>A0ABM1ACF6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC106013556</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012945050.1">
        <property type="nucleotide sequence ID" value="XM_013089596.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013556"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_012945050.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19479" checksum="5826A456E52FD5BD" modified="2025-10-08" version="1">MVNNAAIVNEGSGWQRVIAINLTAVIVGTKLAAAHMRKDKGGKGGRIVSTLSVAGLVQSHMTPVYCATKHGVRAYITGLCKDPTRPDQGIEYAMIAPDAVDTPMFQSVDSNRVLFWDELKDEMKRRMMKPQAVGEAFLQLLRSDVINGAILQVDIQGKTFRHMECVNDGVTFDPSKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADH0</accession>
    <name>A0ABM1ADH0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formin-like protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945595.1">
        <property type="nucleotide sequence ID" value="XM_013090141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013704"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945595.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16292" checksum="41FC810B33D20BF2" modified="2025-10-08" version="1">RPPLPPPPHVALQWGLHPGPAYPGPYAPHGHPPPPPPPPSRFSKARSTPHHAPYTHSGPGGFREPVGEFPLPSSSSSHANAADPGRHRASADPSCGGSGQWDSHPPPPPRLHHHPPSSYHMGAGSSSGLGRSGFHHPHHHHPNKHHHHHHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEJ6</accession>
    <name>A0ABM1AEJ6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dynamin GTPase</fullName>
            <ecNumber evidence="1">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101863954</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="1"/>
    <dbReference type="RefSeq" id="XP_012946174.1">
        <property type="nucleotide sequence ID" value="XM_013090720.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863954"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01256">
        <property type="entry name" value="PH_dynamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="12">
        <location>
            <begin position="29"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="515"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="11">
        <location>
            <begin position="666"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="753"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="789"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012946174.1"/>
        </source>
    </evidence>
    <sequence length="863" mass="97473" checksum="A3DDD4658BF53BAB" modified="2025-10-08" version="1">MSGNVGMEHLIPIVNKLLDVFASLGVPLSLDLPQIAVVGSQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLINSKTEYAEFVHTKGKKFTDFSLVRKEIEDETDRATGSNKGISNIPINLRVYSPQVLNLTLIDLPGMTKVAVGDQPHDIEIQIRSMLMEFIQKESCLILAVTPANADLANSDALKIAKEVDPQGLRTIGVITKLDLMDDGTDARDILENRLLPLRRGYIGVVNRSQKDIEGRKDIRAALAAERKFFLSHPSYRHMADRLGTPFLQKVLNQQLTNHIRDTLPSLRNKLQSQLLSMEKEVEEYKNFRPDDPARKTKAMMQMISQFSTDFERDIEGFGSHVSTDDLSGGAKINRIFHERFPFELVKMEFDERELRKEIAITIKNIHGIRTGLFTPDMAFESIVKKQIKRLKEPSLHAVDLVVTELSNVVRKCSEKMSRYPRLREETERIVSTRIREQEQIVKQQILQFIEIQLSYMNTNHEDFIGFANAQQKSENTNKRKLGNQVIRKGWLSLHNVSFIKGGSKDFWFVLTAESLSWFKDEEEREKRYMLPLEGLQVRDMEGGLFQSKHMFALYNPSSSASRYPYDSTRTPSTRSQNVYKDYKQLELSAETQDDVDSWKASFLRAGVYPERNTEDGGGSTKDDYASVDPQLERQVETIRNLVDSYLKIVNKTQRDLVPKTIMYLIISNIRGFIEAELLAHIYSTGDQNSMMEESADEAQRREEMLRMYHATKDALQIISDVSTTTVSTPTPPPVNDDWLAVENNAGAGHGGGPAPYNNRPPSPARPRTGPPPPLPNRPMDQPLVPTRIAPSVPNRPAPERPMPSIPARPGGSTSGRPVPRIPDRPLVPQRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF79</accession>
    <name>A0ABM1AF79_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxypeptidase inhibitor SmCI-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946518.1">
        <property type="nucleotide sequence ID" value="XM_013091064.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849031"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045078265" evidence="2">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="89"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012946518.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="32108" checksum="A7D38B1746C9376E" modified="2025-10-08" version="1">MRDLLVLLCLLPAAMAAAISVDDEQPDSIFYSLPPDCTPPSDRGTGEGAFTHYYFNQETESCEPFTYSGEGGNRNNFRTRFECRAACKCTQGAERGRREEFCHRHHYYDIYAGKCRQYRYRGCNTKVNRFRSERSCNRACATARCYLNRDRGACDDRIQRYFYNVTAQQCERFKFGGCRGNLNNFGSLEECDQSCSEPIREIDIRTKRHRDCYLPKKEGVCNSSFERFYFNTETGECESFTYRGCNGNLNNFRSEMGCRDKCMPPQPRLAFEEEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFW3</accession>
    <name>A0ABM1AFW3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase ULK3</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Unc-51-like kinase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101860722</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012946852.1">
        <property type="nucleotide sequence ID" value="XM_013091398.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860722"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14121">
        <property type="entry name" value="STKc_ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="27"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="357"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_012946852.1"/>
        </source>
    </evidence>
    <sequence length="588" mass="65796" checksum="F2D7F2F16889AF20" modified="2025-10-08" version="1">MASRPNSAGLQPSATEKLIPKPSLGQYVFTEKLGSGTYATVYKAYSKTGVREVVAIKCVLKSSLNKASTENLLTEIQLLKNLKHEHIVSLKDFQWDNNYIYLIMEFCSGGDLSRFIRSKRALPEHIVKRFLQQIASAMKFLWDNNVAHMDLKPQNILLTSSSSPQIKLADFGFAKHLYDGDNLHVMRGSPLYMAPEIICRGSYDNRVDLWSIGVILFECLFGKPPFASKSFKELGEKIWDQKPVEIPAGFDVSGKARDLTLRLLQRQPRDRITFEEFFAHPFVDMKHIPSKDSLPNAVETVSKAINKDNEGDYKSAVRLYCEALEYFMPAIHYEKSTQKKESLRAKVKVYINRAETLKQLMKPHSSSRPPRPPPPMSPYKASPTSSNKSTSKDSPHHSSQKSKSPETSPESKAVPSASKTPKPDLLSDPVEKSSADGSPGSRPEENTCAESSPPGAVNNSPSSTSQSFARSMSNDVLEELMSLCSDSQELMAVLKLVNAAILEEQEENYESCLHHYEIALGAVLKILPNEPKGKRKNLINAQVVKWMDKAEQIKSYLEVLNLNTQDTSVEDEEEENLLMSQSKQCCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG48</accession>
    <name>A0ABM1AG48_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxylysine kinase</fullName>
            <ecNumber evidence="8">2.7.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106014243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19049"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57882"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58357"/>
            <dbReference type="EC" id="2.7.1.81"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.81" evidence="8"/>
    <dbReference type="RefSeq" id="XP_012946986.1">
        <property type="nucleotide sequence ID" value="XM_013091532.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014243"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050249">
        <property type="entry name" value="Pseudomonas-type_ThrB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064:SF1">
        <property type="entry name" value="HYDROXYLYSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012946986.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29314" checksum="A10919E4BB51DBEF" modified="2025-10-08" version="1">MKATSKAGEERVHKLAVRTFIPGKELGKVTLTPFILYKVGVFVAQLTRALEDFSHSFFDTFDHIWSLNHFPKVAKGLFAVRDETRRRICEEVLEAFNTEVIPQKAHFRKGHIHGDLNVENILVCETVGQGKSFRVCGLLDFQHSASSYLLYELVICTAYAMMAVSTEVPRPLIPGYVLAGYSSILQLNKAERKVFYNLIASRMVQSLVYGAYNAYLDPANEYVLSTAMCGWETLKQFWETPSKDLEKEWGQIVETYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VNP9</accession>
    <name>A0ABM1VNP9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Mucin-5AC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC118477214</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thrombospondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824041.1">
        <property type="nucleotide sequence ID" value="XM_035968148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477214"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025155">
        <property type="entry name" value="WxxW_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13330">
        <property type="entry name" value="Mucin2_WxxW"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFD" evidence="15">
        <location>
            <begin position="89"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="718"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="1184"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="1457"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="1639"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="1845"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="2101"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="3326"/>
            <end position="3477"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="3665"/>
            <end position="3810"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="14">
        <location>
            <begin position="4302"/>
            <end position="4381"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="12">
        <location>
            <begin position="4472"/>
            <end position="4570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="886"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1050"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1347"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1789"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2004"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2267"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2432"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2489"/>
            <end position="2524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2917"/>
            <end position="2953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2997"/>
            <end position="3033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3078"/>
            <end position="3169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3279"/>
            <end position="3322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3481"/>
            <end position="3532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3633"/>
            <end position="3657"/>
        </location>
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        <name type="scientific">Aplysia californica</name>
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            <taxon>Mollusca</taxon>
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            <taxon>Euthyneura</taxon>
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        <text evidence="11">Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.</text>
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            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035824403.1"/>
        </source>
    </evidence>
    <sequence length="1295" mass="150355" checksum="3B18DB130423F9BC" modified="2025-10-08" version="1">MAALMVNGGPPTPDMVEVMRILEMGLVTTIFFYRKRPERRTLKIKLESRQLMWIKSQAGRPEGIANLRDVKEVRCGKNSKDFDKWPDEAKKVDARNSFTVYYGTDFKLKSLSVVANDHDEFNHWSKGLDYLVRETKEACYQLQLERWLRKEFYLMEKIGSYVVTLKNMKAWLPRINFKMSINKLRERFQEFDTDGKGEINYEQFAALYHKLIHVQSVLDENFDKYFEQTWEDRLMRAEMFQQFLVEEQKDPRASDLGYVRRIMLEFLDDQVRAAGGLFFTQQEFEDYLFSQHNPLYDSKYEAITQDMTQPLSSYWIASSHNTYLTGDQLYSSSSTEAYARALHMGCRCLELDCWDGPDGYPNIYHGHTLTSKIKFLDVLKTINDHAWVASEYPLILSIENHCSLGQQRNMAIAFRDTFGDKLLVEPINKDATVMPSPQDLKYKIILKHKKLPEWVDGNEWRYTVSTEDSGTMDVDLSTSIRNGILYLEDQYDHTWHPHFFVLNGSKLYYTEENPSPDQDDEVEEEDIEGRPVDELHFSEKWFHGRLEGGRRKAEELLRHYSYLGNGTFLVRESDTFVGDFSLSFWRQNHVNHCRIKSRQERGQVKFYLIDAVTFDSLYHLIMHYRQFPLRSSDFTQVLRDPVPQPQSHEGKPWYHEGMSRTAAEELLKRIPNDGAFLVRHSGTDQYSYAISFRAEGKIKHCRIKLEGRLFLIGNAQFESLVELVSHYEHSPLYKKMKLRQPVNQALVERLNIAPDDTGIYGAPDLYINPNDFTTKAPDDSDIYEPGIYHLPNDFISKRGTLRRKKKSLRVKALHDYSANRSDELSFCKDSIITNVTKQDGGWWRGDYGAMKQLLFPANYTEEMDTQSDNSSDSAPLGVLQEGAIDVQGCLIDVLPPRGNRFAFRIAPRNNSPPIEIAVDTEEEMNEWIEKISISSSTAVQRTSEQKMLERTMRIAREFSDLIVYCRAVPFNPDEIPGPYYEMSSFPETKVEKWVNSFRAKQFIAYHRNQLSRVYPKGQRVDSTNYNPVPMWNCGCQMLALNYQTPDRAMQLNQGRFLMNGRCGYVLQPDVMRGEQYNPYEKKFLSSLNVEPLTLTISILAARHLVKQGRGIASPFVDIEITGMECDNQKFKTTPQVDNGLNPVWGETMVFDILCPELALVRFAVMEEDIFGEPNFLGQATYPVQCIKPGYRAIQLCNGFGEKLELASVLVFIEMRNPKEGEESDIYATIQLLREESDKLTAEIESLETRGDREHAIVARRELQQTQERLLAKRQERQQRKVNARPQVVYIRQSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQZ3</accession>
    <name>A0ABM1VQZ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Baculoviral IAP repeat-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824835.1">
        <property type="nucleotide sequence ID" value="XM_035968942.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849449"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824835.1"/>
        </source>
    </evidence>
    <sequence length="612" mass="68880" checksum="0FB72D14D094111F" modified="2025-10-08" version="1">MASTSFMERLRTFHSPLPQNFVSSLSNTPVKFAEAGWERADNVSFASDELVCRSCSVKHSGWAGESPLAVHRTRSPNCPFLNTPPIVATNFVGSATTLSSSEIDDTSVEEGAQEPPTVFSICSSCDANNTETLKRKLFSNRSNKNHSGTKYVRREAILHPFKPLTGGYPMLFESLRLTTYSSPGSVEAAKWSKDGFIMISNLRAQCVFCGLQLEFEVCVDIGHVHKKKSPECPFVCHFDMGNISSEEQRSIHEKERTKYFKDISQCNVSSKYRIKYPEFEDSADRSGTFSLWPKLLKTVFPPNTMVEAGFYYTGHNDMVRCFSCGVELFDWIPGADPLTQHACASPSCFFLQQNKGQEYINEAQQQELVVGIKQDSHAQDLEAATMTTAATSSTSSSSSSASSPPPAGPRSYLDLESISAARARGYSTEQISDAIITFFFLTCGQFPDSPLLLGLLKAGTDNHKTLCDKTQEVVDIRSENQVIKSENQAKDTEIQAKDTEIQAKDTEIQAKERELQRQRFERHWRELAMKTELGQALEEKDQVIEENRQVIEENRQVIEENRQVIEENRQALHTKDLQLSMLRQELEEIRERHRPQSAPLDKSDFDTEGRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRX9</accession>
    <name>A0ABM1VRX9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Digestive cysteine proteinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC118477548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825171.1">
        <property type="nucleotide sequence ID" value="XM_035969278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477548"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045389332" evidence="3">
        <location>
            <begin position="23"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="35"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035825171.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="24439" checksum="0D90719595D9C88A" modified="2025-10-08" version="1">MVIMVVMIKLAIFALSVAVASANTDANWLIFKAKYNKEYSCRLEKQSSVTVSIKSSFLEEGQVVGSVGNYGCGGGFEVRAFQYVIDNKGIDTEESYPYKPEDRPCHFKRAGVGATAQAYVNVTSGSEDALQKAVAEVGPISVAIDASHPSFQQYSGGVYDELGCSTTDLDHAVLAVGYGTQDGKDYWIVKNSWTTSWGMDGYILMSRNKDNQCGIATDANYPTGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VST7</accession>
    <name>A0ABM1VST7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NHL repeat-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825479.1">
        <property type="nucleotide sequence ID" value="XM_035969586.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852472"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388:SF2">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825479.1"/>
        </source>
    </evidence>
    <sequence length="717" mass="77928" checksum="D64DC7F21E8F8A50" modified="2025-10-08" version="1">MSSATNVYDVLGVIADFDDELTAESTPDSRKKKITKHLQQMSRIGFKIPDFENGLDWLNVSEPLSFSKQLKGQIVVLDFFTYCCINCMHILPDLEAVEEVYPLGSGVAVVGVHSAKFLNEKVTANITSAVLRYGIKHPVVNDKDATLWTTLAVSCWPTLLFIGPNGELLYSVAGEGGRERVLEFLAVAVDFFSSGGQLRPSSLPISLESDKGQHFDLSFPGKVSFWAERQWLLIADSGNHRILITDVNGIVQAAVGSGQRGFKDGNWSEAEFSSPQGLVGYKDHIYVADTENHCLRVISLVDKSVVTVAGTGRQGFDNEGGKVSTEQELSSPWDVELGNPQLEGSDVPVLFVAMSGIHQVWVYFLSDGPWFKKRSYPKGTCLRFAGSGREENRNNAYPEKASFAQPSGLAVGSKGSTSTLYVADSESSSIRTISLPSCKVSGLVGGEKDPTNLFAFGDEDGKGTNAKLQHPLGVALLADEGPLVVADSYNHKIKIVDLATSVCETLAGTGQAGGTVSPSDLKKTEFNEPGGVSVDRERQLIYLADTNNHAIKVVDYTKWTVFQASIQCIFYLQLPIVFPKDSPSEKVVEPEGNYEVLPEISCSACGKEVVLSVPLALSPGEHINMEAPNAWKLSAFDETGQKFLETLNPAERKGKLCFTKDNPTSSEKATFRINLSPSTSPGRVNLNISTQIFVCLDDENVCLPPKMGQFRQSLNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTA3</accession>
    <name>A0ABM1VTA3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118477686</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118477686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825645.1">
        <property type="nucleotide sequence ID" value="XM_035969752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477686"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825645.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29369" checksum="79D85FC9179CE17A" modified="2025-10-08" version="1">MGRKEKKKKKKSSYSCDDAEQQTPCSIPMVEKKNSFASLDPRPNCTVVTLPARPSQALLPQKQSPESLDECAHPVVSGTGAVATCFFLIGLLMFLVAFGSHDWLGLEKGLTISLWRRCVRNYDLNVWGCKPWKTVPEFVRAAQGFCVVGMLTYALSVIILIAYVTVQFLQRIRGVLIALCLLIFTAGCMTLMALVVMGIKGNDYLKNLKLDEREVIRYLGRSVDVLGGFYIGWSFIVAVISAFITLASFMFCMIEFVHVSDVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VU96</accession>
    <name>A0ABM1VU96_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825988.1">
        <property type="nucleotide sequence ID" value="XM_035970095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477784"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825988.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="24391" checksum="A0D39169D310B1B1" modified="2025-10-08" version="1">MVYMPPVTIAPIKEAKKEMFEEMKAPSHAYPSNDLSHMFTNGDISANRMFSTGGSSMVMPSSDPFVHQPSVTSARLTSSDRGLGPGIAAEFSPYGGMYSLDSAYYHYYQSLQDSSNGNYFMHSDGGAADYVNPNAVMPVAPYASRSFSGSSRRLDRPADLACYSVINPGDVYNNNSSNNNNNNSSSTSCGSSSNNSSSSNNNHISSIGNSSTSTTYSSHLSNYKCADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUP4</accession>
    <name>A0ABM1VUP4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor subfamily 2 group E member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101860140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826136.1">
        <property type="nucleotide sequence ID" value="XM_035970243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860140"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07163">
        <property type="entry name" value="NR_DBD_TLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="67"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="215"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035826136.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50156" checksum="85A1C2A17E1DA535" modified="2025-10-08" version="1">MGIEPTFSACAFEVSSRYTADTDRRSSGPFLQTSRPPDLQASTAPATLLIFPPIPHDIKKFCDRLLDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHKNRAYTCKAQGPLKGRCPVDKTHRNQCRACRLNKCFEADMNKEAVQHERGPRKPKPKPGELPGPLLVDTRGQNSQDHPIDLSVTTPCRLIPLQYHQDIAMATPPVFPDSHMLMLSGYMNRFNDLMRIQVCLVFRLPIIHGPSAFTAPLAPPLATSFHHDILQEVMARLLFTVVTWVKHIPAFITLTPGDQTMLMASAWKELFLLGVVQWGLPVDHLSQMTQRDDASTSAVDLEECETLTDLINRLREMSLDPTEMTCVKAVALFKPDVASLSDRRQVQSIQDQAQLMLNKHIQLSYPRQMIRFGRLLMLLSKMQTISAGTVERLFFRGLLATSSIEKLIGNILHGEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVW8</accession>
    <name>A0ABM1VVW8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012242</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826560.1">
        <property type="nucleotide sequence ID" value="XM_035970667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012242"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826560.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="58326" checksum="317E6A60A8575A57" modified="2025-10-08" version="1">MGNDISTAYPSESDVPCSVLQDELASLAQGEYCELEISSENEDLKTCRLPFAFRRCLKNPGHKDFVPIKELRQEHLPRGCSSVATLKWLKSWAHSVVRLSVRYVSKDRPKNFALPSSKGTKRLAHGTGVAFPQQSDAAHPSTTQEPRTLLKIVTAAHVVFDMDEVKHTTVEFFFDDDSDRSGVVRGKGVDLYYSLPEEDICVFFCELDKPGELPAVLEKLDQTYYAPDIFEDVSFCISHPHGCAKRVSFGGLNELKATHFEPKPPYGSGIVVDVCGTALFHFDEKKFFYYFILDVEMKRLVNLLPKLCGFTSKVLIDLETKGLVTSPSEEELKEMRDKLSENIGILTGEQSNLNSDFDQISDDEDSSCYKDGGKGEPDNDSHKEEEKEEEEEGEDDCECPEWAALSEEEKLKRVKELFPCELDDYDDEFLNAFSDRFHKLMSELGQILTEINRSESRASETGEQHAFAHSIPTCQGSSGAPIMSLSCVDGKHKMALAPHSRHPRLQPLAKSAFGFTWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWW1</accession>
    <name>A0ABM1VWW1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Metalloendopeptidase</fullName>
            <ecNumber evidence="14">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101854104</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_035826903.1">
        <property type="nucleotide sequence ID" value="XM_035971010.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854104"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0420">Kringle</keyword>
    <keyword evidence="4 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0768">Sushi</keyword>
    <keyword evidence="7 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="20">
        <location>
            <begin position="94"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="19">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="595"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="17">
        <location>
            <begin position="715"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="18">
        <location>
            <begin position="831"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="16">
        <location>
            <begin position="897"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="19">
        <location>
            <begin position="1019"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="19">
        <location>
            <begin position="1058"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="732"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1019"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
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    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    <sequence length="1096" mass="122682" checksum="59AA605836C4F8D5" modified="2025-10-08" version="1">MQDDVRFEEDPEFALIMAWDAREKEREQIHGLSHGEEELEPDHNTDVEEDYINAKKASIHSKLNDKLEEMSEAARKQRNIGDGRPEGGHRMRRNMVESLQSRLWTKGIVPYVIEGAVEGVVNASIDRAMKVMSSLSCLSFVPWKKYSNGSTTNDLLNLGHDGYLFFLIKGGYSGCWSHIGNRNVSTGQEVACCGGMVCVHEISHALGVHHEHQNPGNEGWIRVNIKSVQDLYKVHLSPVYDTSLYKEGYDVTSLMHYGTSFFGIGGDPTITFLMPEMTPKTNIYYIKKHLNMVYDCAAVQCPSFAGACSNEGYVVFEKGQCRCQCPYGLDPLSGCNDVISKGISSFKFPSGSFALPRTTSGCLEDFTEGSLTHYPEVESCADSQQYCSYWAKIGECQRNPNYMNQNCKLSCDVCDKTGSWSSTPSTLSGSVTRQKATHDFCVNDGAASDPNTAWPIGSYCIYRKGGECPDGFNQGFVQFADVSNSTHGSFNSGDLPDGTFTAHGTRLEFCCRDDGFLHMPIDLPSQNEFALFQKFMGCQEINGMHVYPEYSVFNNLNSGQAEISGDTPVLEYHKLYQQYIIRTCVYRPVNKLADCGRMVNIDSDNDVFFQPNFSGQDAECTWVFKAQENDRLRLTFPVAGVTGVDVNCEDEVEIRLARLGQPGLIHCGAGLHKDFTSVDNVMALTFRTRHGSNSTLSFIVSLIDDETHCYNTQDKGRSYSGKVNITRNFVPCLDWKSVTHCPHHAFSQGDALDNLEGNYCRNPGNGLRPWCYTEAVGCVRDYCEVCLMEHPQDSLPDCAQLAKTADFCETEPDAHSLCPLSCNSPRDVSVVRCPAPEDLTASSIITTPRLDSYRVGDVVTYSCDRNPSTVDRMCLSTGQWSPLNHACEECPNGWELSNGNCYKHFPVPLKHSEARATCAMYNALLSSAKSPAENTFVANMRPYVKEIWLGLSDIATEGSFVWDDGTPLVWSKWSSDDPNNLNKNEDCVFMRRNEWWVDVPCDNYLRPFVCKRPREHDPCHDLSRHCGWWANNGECQRSPGYMNYHCKWSCNVCPVAVCEDLLPSCSDLLTFDQDACTQYPDFMKRNCRLACNLCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXS0</accession>
    <name>A0ABM1VXS0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitotriosidase-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827213.1">
        <property type="nucleotide sequence ID" value="XM_035971320.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477181"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827213.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38882" checksum="AFB5F9B1B773297E" modified="2025-10-08" version="1">MSVENRHKLAQVRAYMRVAADKQHPLHKAIEAIKGNCLKRGASWMAEAENTIKEVCRLEDIKRDNYKLVTSLKNDDPDLSVFLGVGGPSDISLDFSSLVNSTEMMEEFASNAARYLRDSSLGRYGGHSGTAARSPRNRKYHAVIPNTSKDWEGEWLRRGERVLSRSFDEESSSTGLPVLRLALAISGDRDIIDTAYDINALQQSVNFVLVKAYDFYTSEFPLLGHHAAIYPSENDQGFGEDKNVDFAIQYLLYLGVPSTKLIMGLPSHGRSFKFLNESEKYFGALHGGNGVPGPYSQIPGILTYYETCDLLNKGWTSSFHEEHQVPFAFSSEEIVTYDDVGSMTAKVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZ78</accession>
    <name>A0ABM1VZ78_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012808</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827721.1">
        <property type="nucleotide sequence ID" value="XM_035971828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012808"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1572"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1613"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1702"/>
            <end position="1712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827721.1"/>
        </source>
    </evidence>
    <sequence length="1870" mass="202334" checksum="A90C5C3B1B075DD2" modified="2025-10-08" version="1">MFVESTAISAGQSVRVDVVTTCPVISNSQTEDYPQVTSSLQRVSVKDAVSFWSNQNPRSAEKLSFVDVLRSSRSDSAAGVRSTGDQQSGGEACPSARRAVFKREGDAVRLFLVEEEESVVSVSESCEARTSDYNTRSPVNSNTSFSDFSRGGISTSREGQWRPAAGNLTSSSSSSLGSTGVKSQNKSGGKGSNTSKSRKFPKLLGGKKPQGKEAKSPELGRKSIGGVKSPELGRKPINRWDRIHVPLGRSETVLPPPEAQTAVPCLSASVLSDLSDTLTSAPSPGDPRLAPDVTRVPQDGEGLEASARVNGSVNKPDSRPAIKGILVYRGPHTHTHGAPARHGHKVNSVQFLDDTVLPDSATTPVTSSSAPWSGVDEQFSGPDVKREVIDRRKYFIDPSEAKRSGHFLNRSHDGVLHTNNTLGTSLDGVLHTNHNNTLVVSPNTRVTPDTESQLSRVNPSHARFDYPDGRVNPSHSRFDRSDGRVNQSQLPVQSSITEGFSQSARVSPPPLSPPLAPLPSAHLASPTSSADARGQFEPHDNIGRSTWADRQAKYNGQPHDNFSDLTTDLNQLTESRVSSAGLRPSFEQTLQSNGPSGPHSDSSAGRDTSVVRPGRASDYLGELENISSDLSISATSGVQSWRGQTKSDVPHWQSDGDLTGDETLDYRHHVREQCQKTLVWNSLPVTSDVSQAWLSLRQDNGTTDVHTLDLDPSSRVQHSSGENRQPPRAGDRPGKITPRQKFEILHNRGPARVTGNLRASQEGTTHRPTHEDTHEETEPACHRTSAEIQHTSHHGLPSETQHTSQHLLPSVARLSAAHPGSCPAHKESPRAKFERDRAARTHGKSSTSTAPADGSQLSPGGETDTGLSGGRNFGAEISGEEDSRTSSLTRSQKVKDSPSSHPNPTCVQLTSQQHVPEVPPRACAGARVSSLPGVVRGSEVKKMSPDSVSSSGYESEQNSCVLHPSSGHVSSALTSDLGTSTVQQLRLRFGHSDKGQGQNKLNNSRRGEVGNTSVLCGISRVDQTSLSGHSSTPQRDLNTRNCSLERQTTVVTSHSSTRRHSAGDVIDDVDHVSSDVNNNIRSGKAERRGRQLSTQQPPAVRNNGQHTQGLVQKLTNQQSVKWSLAQLSGLEKHLSVSRVNYSPEEEEREVRDKRDVREVRERKELRNEREVREQRELRELREPRLPGEARPFSESRPISFDDSAMLASKGLRIYEAGGEYIAMKSPVKSPLRSTMSAPHFRWEGATYLVVPTVLEAFSPTGGESPGSNLSPGADHFVGGHHHPGELRTHRSVSDSGAGWGNREDLAADFINSATNNSNNNSVNLKGSQARASLSSERDITNVMPGRGGTDSSSGDLYLPMSENRSNLTSRAMSVDVLYADPPPSPRSLTSPLSPHSHLSPHSHSLPPGGSAPTTTTTTSVRGGFHPSTTKNPADYVQWRTCSGWVGTTDMRARGSRDGRNSRGYVEWDTIWTTAAPWRGGDQGEDEHVYDVIAEDSSSQQSLEVVGLNPSAVGAGESSNKEVTPVSIDTPPALPERTYINRLKNNKLNKNKNNSNSYTNGSPCQQHRLDPSADQTSVNNTLSPHHHSHCKKHRQHRQHHHHHHHHHHNHGKQLNKQQQQQQQQQQQPSSHSSPSQTVPSSSTSSSAPSNHKAPPSSSSSTPSNQKTPPTSSSSAPNKQKAPPTSSSSAPSKHKAPPSPNSPTDINSDPGSQNYAQVSKLKGYKFSNLLTTTDSPLPHQPDKGAIYSENYWHLAPVTSEERVTSWQTGDVLDYIDGLHDAMAAKRRENIYILLNNKKTRAKFSESLEIESRLLSKGLITSTGSRQNSVESAEVPVSKTINVENASSPKDPGLDVGVTKKKKALAPVSSTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZL3</accession>
    <name>A0ABM1VZL3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">O-phosphoseryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5 18">2.9.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 18">Selenocysteine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 18">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sep-tRNA:Sec-tRNA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">LOC101856918</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 18">Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H2O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:25041"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="Rhea" id="RHEA-COMP:9947"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78551"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the SepSecS family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.2" evidence="5 18"/>
    <dbReference type="RefSeq" id="XP_035827856.1">
        <property type="nucleotide sequence ID" value="XM_035971963.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827857.1">
        <property type="nucleotide sequence ID" value="XM_035971964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856918"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019872">
        <property type="entry name" value="Sec-tRNA_Se_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008829">
        <property type="entry name" value="SepSecS/SepCysS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03531">
        <property type="entry name" value="selenium_SpcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944:SF2">
        <property type="entry name" value="O-PHOSPHOSERYL-TRNA(SEC) SELENIUM TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944">
        <property type="entry name" value="SOLUBLE LIVER ANTIGEN/LIVER PANCREAS ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05889">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017689">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12 18" id="KW-0711">Selenium</keyword>
    <keyword evidence="8 18 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035827856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035827857.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="52447" checksum="C69A3AD4801949B2" modified="2025-10-08" version="1">MNQEVLDLCCKLVPENYVLQGAQARNTHEHKIKHLLQHRKIPEDGWDDQTIELFLQELAVMDSNNFPGNCGVGEREARIASQLVAKRHYRLGHGIGRSGDITAVQPKAAGSSVLMKLTNSLVLDAIKLSGIQSTSSCFVVPMATGMALVLCMLTLKQRRPKAKYVLWPRIDQKSCFKSIVTAGFEPVIIENCLEGDELRTDVATIKQKIEDLGADNVLCVMTTTSCFTPRVPDRLEEVGKLCKQQEVPHVINNAYGVQSSKCTHLIQQAARVGRVDAFVQSTDKNFMVPVGGAIIAGFDKKFIEEIGKSYPGRASATPSLDLLITLLSLGSSGYKKLLDERKQMFSYLSSSLSECAARHGERTLQTKNNPISLGITLSLEDDPTGVKATQIGSMLFTRFVSGTRVVAPGKDNRVSGYHFKNFGAHYDNYPCAYLTAAGAIGMTKSDVDLFITRLDKVLSKYKTTPSEEVPAGTEEKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZM1</accession>
    <name>A0ABM1VZM1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin reductase-like selenoprotein T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827864.1">
        <property type="nucleotide sequence ID" value="XM_035971971.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863928"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019389">
        <property type="entry name" value="Selenoprotein_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544">
        <property type="entry name" value="SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544:SF0">
        <property type="entry name" value="THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045708668" evidence="3">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827864.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22297" checksum="50D66E717D45E990" modified="2025-10-08" version="1">MADFGQLPFYALCVGLLFLTYRDFTSSQESYSVQKDIKAPKLSNFAGPTLKFMFCYTUGYRKVFEQYAQALHERFPALTIVGDHYPPPVVRSSLAQALGIIKFILIGLVVTGYNPFPSLNLQTPSIYTWATENKLYACLMLFFISNAIEGQLISTGAFEISFNDVPIWSKLETGRIPSPSEMFQMIENNLRYVQSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZV6</accession>
    <name>A0ABM1VZV6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478447</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827949.1">
        <property type="nucleotide sequence ID" value="XM_035972056.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478447"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055475">
        <property type="entry name" value="DUF7047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23088">
        <property type="entry name" value="DUF7047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7047" evidence="1">
        <location>
            <begin position="420"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827949.1"/>
        </source>
    </evidence>
    <sequence length="731" mass="81945" checksum="23EF5317D0933B43" modified="2025-10-08" version="1">MADDDDDDNPRPLSISDVCCLLLSAASQTTEQAQCSGAGRFCLSLLTCTVDGFNHPEETGSGVHNQKPRSDPSACGNMSEALGPKSLLMPLSMVRAETCNFRNGISVWVLRAPKFQSAVVIAKAASTLVGRSNVQFGGGVACASIEPEKRSDTVDADLIVRDRDFEASFDGRIWTVKYHWIEGKAPVLKNKVSRCNHEMSTEKVTSFEQEVEKWINEGILMPWDEEVDEGIIPLMAVDQVNKNKVRPVLDFRELNEAVECHTGDDLIDVCDDVLRQWRQVEGDTEIVDLKAAYLQLHVSRELWKYQLVRFTGKSYCLTRLGFGLNCAPRIMTKVLKTVLEQRDDIRFSTSSYYIDDILVSVSQVSSEDVISHLRRYGLVAKPAEKLEGGTALGLKLFRGPAGRLWFGRSGELPRVNRRLTKRELFSLCGKLTAHYPIAGWLRLACSYVKRHSGGEKWDSYICDRAQVMVEEIVARVGKDDPVRGEWGVEHATDGTVWCDASYLCEGVNLEIDGVVAEDAAWMGKPDDYHHINVAELDAVLKGVNLGVKWGLKDMFIMTDSVTVGRWIDLTLSEERRVKTAGAAEILVKRRLAVLKEMVEELGLTIRVQIIGSKGNKADAMTRVTKEWKEWAKVDRLGCGAVGVSAKELHDQHHFGVERSWYLARQVDPRWNVRPFFRAAYRPGGNGIEERNHRTIKAIAERGNMSPVDAVFYYNCSPRYRQEETPVLKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0U6</accession>
    <name>A0ABM1W0U6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101846459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828289.1">
        <property type="nucleotide sequence ID" value="XM_035972396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846459"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828289.1"/>
        </source>
    </evidence>
    <sequence length="1358" mass="150781" checksum="7F550F0FB1E5B1C5" modified="2025-10-08" version="1">MASSTTVARKSSHKKHGLSKKKSGKTMKSGKLNYNFSDESDEEIKAFPKEQVKVFKKSKTPEDKTPVFKKALLNSEESVLASDSLRRKSELPTVCEDFGLPVTESTRISTSPTNSRRSDCIPVLEEQENEVPNDCRQSKNQKFIKSPGNNCQKKPFQNGVLQDLASDNLRRTSELPSVCEDFGLPITESTRISISPTYSRVAGRVDQNKEQQNKVSTNKCQNSRKQNVEKSRVSNGPEKLFQDEILQAVKQEYFELVHSLPGTNVYNSFVEPDDTNSSSLPISACHGQQSLEWDHLPDTTMNQSKFGSKKCLLGGIRERTVPKNDDSKLRKKHRVSSINPLMHGGSTLMNIKLEDVKDESVHSFLGKETQGLSRDSYVEVQDVSAQVNLSSVLENTSSEAEVESCGNEISCSDGRLSQPADSFVEVQDVSVEANFTFGGSNEVGREGLERPAEENESTDITGSVSTELSKSLVSDIQSCELSVEHGPLSPNNKHHKSHPINENSGSMKQFHEQFHEHHSLPDSVDGRIDSPSVEVPSSSCHNGDNKSSQKLNNNKEENGNVDLQVRERDTVYTLESGLPGSAGKAKEHTGADVPSDTSDYYSCHTTNSNQSDFDTKSSLNSDKTSLREASSCRTTYSGVQDVFSPSSTHVKNQEWSRQDDQASPVKESDNMSEKSVTLSPCSDDGRSEQGNTLYTTARDNIFVSSETFQPKGDSSRWRICESLNSDASGDESSMKENGSEIIVPATDSEDDDYYSDEQSIKVIASSFVEDNDGDLALGEIESEGELRKENSLCGLVTYNDSSPQERKTSVLTNKGDGGEMDLGDGDSLKESTSNLKERLDSTSVSEEVDGSEHDDEDSRVGDISGRGVVVQPEVKDLAERQRMDSSDDDSDFENFLEKMKTQCDIKKQKQEDLRSLDDFVVSDAETEGSDDVDSGTDGDDEEDEMLLAKADRKTVGRHLRGGKSLVLKSVDLDEESNEASARQDGKQKISTEYKIKSQRDKGLNGVERSDASYDSVAKTPRRLLSSTSSMGSVVDDRLLSDDDDDFKPQKTNFRTPVHAPPQATKPFHGHFKTPAKPRLKTALPEHPMTAPRLSVKSALGVSDDSSFLESLSSDLPDYKRHPEALRFLRHFKSMTVKAELTTKLFTIFNSKVFEKKLPADLPIEWNSRYLKTAGTFSVRGTKDNLVGKISLSAKVCDTPERVRDTLAHELCHAAVRLINGVRESHGPFWKSWARKINKMFPFMPVISRCHDYTIKTKYTYQCVNCRYRIGRHSKSLDTDNKVCGHCQGNFEVYLTKDLESSIERSGNSTPVTPRTPNKFALFVKECYSEVKHRQSGISHGDVMKILSKEFAEKNKISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1Y8</accession>
    <name>A0ABM1W1Y8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828681.1">
        <property type="nucleotide sequence ID" value="XM_035972788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854984"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828681.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28039" checksum="5448F163C6D19D7A" modified="2025-10-08" version="1">MAVSSLAEVLNQAGNEGRFQVLSLLAITLPRVPIHWSLTMMSYGGYTPDWCCVPSHLNVNDECGVVVANAYQGPGTSNYSTAPSVPSLLSQCLNDSTCPRKQFVSEDDASTVVTEWDLVCDLEWVVPVISSVQMGGVAVGALACGYASDLWGRRRVHFSMLLLHTLLNVIAGFSVSWQMFAVLRFFLGVSIGGYTVVHVPYVLEFQSPRWRAIPAAVPFSPLGASLLPLGAWLLPDWRWMHFICAILNAPFLLTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W373</accession>
    <name>A0ABM1W373_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Aprataxin and PNK-like factor isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC101847231</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111544.1">
        <property type="nucleotide sequence ID" value="XM_005111487.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012945310.1">
        <property type="nucleotide sequence ID" value="XM_013089856.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829116.1">
        <property type="nucleotide sequence ID" value="XM_035973223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847231"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039253">
        <property type="entry name" value="APLF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315:SF2">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PBZ-type" evidence="3">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012945310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829116.1"/>
        </source>
    </evidence>
    <sequence length="688" mass="77316" checksum="6557EEE805FB29DF" modified="2025-10-08" version="1">MPGITLQEVGGDLVINVPDDKIVIGRGQFLQVSDKRVSRSHALLEITDGKLYITPTHTNPCFLRSQPTKEQKILTRDVKQALVHGDEFGLLPDQFFYKVSYPQINGKSSDDVKEEIKESEKSESPANAAVSNGDSRDESGKDRQESNENTEKPKEKSAAEPDQTEREQKPQEKEKDKEEESEEEAKPASKVLHLEGKGDMAMPLEKKRVLPDWMLKVAGSTSPVKAKPAAKRPVATAVSKREPGTKLTTYADDDYDDEDEDEEEKEVYKPRKRAKVVVNSDDEFDENFSDDDYVPEKTSSRGGRGGRRKRNVSDSEEEDDFSDDDDDDYSPQRKKARTPKKATPKRGKGKKGGAKGKKTPARSPRKTPQRGSSRKKKNSDDDDDEDVSLPRGAYDDDDDDDDVGSGRRPQRAARQKRGSYVDDPMIEEALSDFASDDEDINEDKDSDFQVEGEDDSGSDWEKKQKQAPRVSKSRAPPRAATKRGAGKKKKPRRPSRARNDSDDDDEDDLEDDEPYVPRPSKRRGGGKLSRDSDESDDDKKKKRRREPCQYGKKCYRKNPVHFRTFCHPGDSSYDEEDKDSSPSGKESTRKEKESRASPEKPSRPQRSTAGTRLVTHGVDDDDLPDTYDYNDSFIDDDATQQTDNSGGEDDSDYDAEEDVRGLAKDAKKFVKNKKLNKPVGKVIQPDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W386</accession>
    <name>A0ABM1W386_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Plasminogen receptor (KT)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101857612</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829128.1">
        <property type="nucleotide sequence ID" value="XM_035973235.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829129.1">
        <property type="nucleotide sequence ID" value="XM_035973236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857612"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019319">
        <property type="entry name" value="Plg-R(KT)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411:SF6">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10166">
        <property type="entry name" value="DUF2368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829129.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17908" checksum="548028D1693E8518" modified="2025-10-08" version="1">MGSFLGKTMDENLKKNQEFMLKAQQLQMERQLAMQNEMRERQMAMMIARSRDFFWYWMTFNTLATVGLTAGALRTRRWGLLAPLVPLGIVTTYQWDLAYGPKIERMREMADRILDEEAGLLDLPHGMPTFASVESARLKQKSDEPYKPGHDIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBL2</accession>
    <name>A0ABM0JBL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Cyclin-D-binding Myb-like transcription factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC101864663</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005089919.1">
        <property type="nucleotide sequence ID" value="XM_005089862.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089920.1">
        <property type="nucleotide sequence ID" value="XM_005089863.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089921.1">
        <property type="nucleotide sequence ID" value="XM_005089864.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864663"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046775">
        <property type="entry name" value="DMTF1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20588">
        <property type="entry name" value="DMTF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="378"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="378"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="449"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
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            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005089921.1"/>
        </source>
    </evidence>
    <sequence length="773" mass="84954" checksum="719E8F2FB8712D7D" modified="2025-10-08" version="1">MMEDGPSTSSFESTSLVIEETEEAGQDVVEEVKTADSSMLPVITEQVNMPDGEFVQLAHDGDEEKMPVEFKSEPTEISEIGGLDHFVTVTEVDSEPTVETSELNENTEMGTVMKTEVISSESADSSVPESIQQAVPQQFIILTRTAEGGAEPVEIQGMPSKYIRFEGADGQTYVFAVADDSSENSDSVKALPTQQIVPAKNVKVSRKRPASVSSPVTAAPATSPTSSRVKSTHNANTDGINQAWFTTRDDKNALHKEGHQWKQGQWTKEEVDVLETNINNYCKEHNIKDPAEVIFEMSKDERKDFYRTIALGIHRPLFSVYRRVTRMYDRKNHRGKYSTNEMKHLRVLRAKHGNDWAAIGVALGRSASSVKDKCRLMKDNCKSGKWYPEEEARLADAVYKLTGVKPSESITSGLSWASVAEHVGTRSEKQCRTKWLNYLNWKQQGGADWTRDDDQLLIEKVSNMNVNNDSEIDWVALSQDWKSVRSPQWLRGKWWALKRHIADYNKLSYPALLEQMKQVIYWNLKPKAGTRTIKGESQSEFFKNCFPVSITSGVDGSSSLALSYCPSEEEGGFQAFEVLQQWTPQVIGAVAQAGNAADGTAQGILSGEGHIIVHTLAPGLGENIQLNGQQQVIISSAGIHGEGEEGVEGQEMTIQVAADGLVQTDQGLHTLSSSEHLDSEIPNTFESGSEEIVAVSEFHGQPVTGEQDIMSHDVFETVTSEAGGDLGMGVASPTHTSSLMTSLKDPILMSSSDVECEKSQSAELTDEASGLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDB0</accession>
    <name>A0ABM0JDB0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC101846553</name>
        <name evidence="6" type="synonym">MED18</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091072.1">
        <property type="nucleotide sequence ID" value="XM_005091015.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944483.1">
        <property type="nucleotide sequence ID" value="XM_013089029.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944488.1">
        <property type="nucleotide sequence ID" value="XM_013089034.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846553"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005091072.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012944483.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012944488.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24273" checksum="E6E5860D70EBF3C2" modified="2025-10-08" version="1">MEAAVLAPSLKSIAPQQEYLLQGSILDAHRDVLLHRLRGLCDNAENSPESFNDYEAVYMLRNSSTTQQSQFVLFRVRHALDRPDAPAHIRYLGQAEVGDRGRHTLVRACLDVACSPNVRDFLMEMGFRLDHDYVAQGFFFHKGRMKVTVYKIFKLQQPGKTDQSNLEPLGSSHLVELSVVAPLGQEQIGDDMKNFAEQLKPLVSLEKVDHRRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDF6</accession>
    <name>A0ABM0JDF6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Probable JmjC domain-containing histone demethylation protein 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101861260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the JHDM2 histone demethylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091148.2">
        <property type="nucleotide sequence ID" value="XM_005091091.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861260"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054294">
        <property type="entry name" value="DUF7030"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054503">
        <property type="entry name" value="KDM3AB_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054504">
        <property type="entry name" value="PWWP_KDM3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22989">
        <property type="entry name" value="DUF7030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22988">
        <property type="entry name" value="PWWP_KDM3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22987">
        <property type="entry name" value="Tudor_KDM3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="15">
        <location>
            <begin position="2570"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="256"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <end position="684"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="698"/>
            <end position="719"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <end position="813"/>
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    </feature>
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            <begin position="1000"/>
            <end position="1076"/>
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    </feature>
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            <begin position="1156"/>
            <end position="1175"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="1257"/>
            <end position="1414"/>
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    </feature>
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            <begin position="1430"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1610"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="2262"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="2359"/>
            <end position="2378"/>
        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
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        </location>
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            <begin position="414"/>
            <end position="438"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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        <location>
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            <end position="1368"/>
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        <location>
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            <end position="1549"/>
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            <end position="1674"/>
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            <begin position="1686"/>
            <end position="1699"/>
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        <location>
            <begin position="1700"/>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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            <end position="1807"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="14">
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            <end position="1818"/>
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            <end position="1935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1947"/>
            <end position="1969"/>
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        <location>
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            <end position="1979"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
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            <end position="2333"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005091148.2"/>
        </source>
    </evidence>
    <sequence length="2815" mass="306403" checksum="D0C0F6F53CBFDC61" modified="2025-10-08" version="1">MSSKCRDELVGKRFLSVKAEGRLKVGKISEWEWRSGFIRAVSTRDSSNADFTALVEFDDTGWKSREYIKVHEVFQEFLVEYSLAWVPRNEPNYPPHTVAPWPALCYKPVVDKAELFQQGKRPVEFLSDRSLGFVDKHEITVYKEGDENSAPVASACPEVRKWVKTWTDYQDGQKILLTTPTVLLGYRVEVYRTEGTTQWYTAVIKSYNHATKNLTLTDDTVLEEHNEDPTLIQMHLIGDGVVDSILNGVDVGVAQRRRPRSTVTKQVNKEPLVTSQPSRVLSQSTPSSSPSPSNSQSRGGATTPAASRVTGSRSSRTAAAAAAAAVSITAATESVPSPSAGASSPTADTAGHKGASPTKNQKPAAAKRRPEPAAKSSRSKAPPPAGKKLKKSESEENLDLNPPVCKQTCNVLVKRIEEEPQRSSVTKEKVPRLREKARQSRKPPPPSSEKKLEEQNTEPTATGKAEDPQSPDTPPVCEEVSSKESVSQSETSGAAEVKSGEPEVAPPESVKVEVSGEKLSASPAPASEASVVSVAAAAAACEDGSKPEATVSSSSPVTPTISAPGPVVSKAGDGPVSVLSPSSCPPGHSQSARGSKHDHQSHTPSKLTTAGSVKPKIADRFLGTGREDKKCVGVSEASSNSVSVVHPEQGNEDMNFKKQILRARRNISPSPNTQTGSVSEGIDVNRSLTEQLAKRTKTFEQFSVNGDGKPPGSEPPVLIDRVKSSPCYSAYHLNESSPSLSKADFISERHSAFTCVQSSVARSNTTTPATEDRADSRASDGQLPPHITEDKRPGSRLDDIRSSRSSPGSSPLIVDRYEAVNPYRDPELMRKNPVQSNVPNILTAQHKMNQSSFPSVPPAVPGASTPSQTAAAAAAAAAFSGVPGVPPQLPARSLLSSLPSTLAYTSNPQLPPSMSPHLTLPHGYSLETMAAVRAQQQHLAAIHQQLMNYPTATFEAIWQRKLPTAPLAQPWAQKSQESLLAGDLAAMHREQMQLHIEQERRERERLEQERRERDRLEQERREKERKEMIERERLEKEKAEREKAERERQERERQERERQERERQEKERQEWEHKQNQERILKESVDTVAAVDQHFAESLTRLATQHGLAPGILPSISRGTGRGFMAKSEGQHSLPPHSLAYQEAKMMKREVDIPDDKRFVSKGGGPAEKSGGTFPGYPYNSGGGYPPSHKPVFNLYGYPSAHSTISSEQLKKQLIPESQPIKEEMVDKKMPYSALPSHAASPHHAAAGYLPKDLKPHNSVIVKRDMKSEIKMETPVAAHSHHNSPSSSSPRPQHPRPAHTPEHRPERPLSSSTSPASGIPPHLLHHSSSSPAGPPPPSHSTAFRAVEAHASRSQSPYKPAASQSQQSMPLPLDYHKASGPSKVKAGEPHPAASHPGYSTSGPAVPPPPPVSASSAALAYSYSLIQQGLVPNPIYSQGGAPHPSEHNSTAHRMPVPMAGMPQGGPKPQVSPPGMKRKPTASSKDPSLYNRKKLKGQAEAPGQAMSIPVTTPEILTNPSPYTTTSSSSVFSKPGSTSMSSASPSPSLSASFSSMNSGFMDNFKSFVENTVHIAFLQDEKKAQEKAERERVNNSAALAAGPVSTKFEPNLLERKSDCVPGGQPPAVVTSQMAATSAPSEVPPTSLNAESSYNSRIMDTINRVANNQVDTDSDTLSASSPPPQIKPSDTSSPLNRSGNSSGSSHPHHMKKAWLQRHDEDKKSETPVAPPPAAPAPVTQEEQQRPVTQAARDSISCVENSGATGEGGLSSLSSSPANVVVTLPNGNISDLNHRNDESTSSASEAEMQNSTKNAGSKKRVKSRKSGGSSAGAGAAKKAKAETEPESVAAASPSSAVSSNSNSSSSRKKTPASAKRGKTEKDVKAKEDSQQSKREDQALNSSKQSRDNSPQPSKLPERNTKAGSNATTTAASTAPIVSSPSPHSDRSNPSPTLSETNPTSTASSTSSSSSPTTSNSRLQNSSGANSKENKEKKKPRRSKEAASKDSSSFNKPLVKQTVATLKKTMVPFIQDGPCSEITPKLTKCRECKMTPVQRSKKQPNIFCRFYAFRRLKYSSRGIVTIDGFSELSDADPDDIEPWLPRYPVEEPDLDVENSKFIISKVGDKFCELVEQEKEAKSWAVKIAWKRAVQGVREMCDVCDTTLFNMHWVCQKCGFVVCLDCYKVRMKEGKKPAGEDKWLTCSSNRQAHEASKMMLTQIIPSDALWELGRLIHDIRTKWSIPSNCPCGGSNGKLLPKNGITQQILSVVNSRKLPNGVGSEELSGKSAKSKKQQDSGNPLKNLGNYNPDTSSSPLSILAEVASMEPDSNREKPGDQGKGKLDKTAVPGDEFLEESEKKSSCTSLRELLTKTAGKPKMSNEKKGKKGSGTNTLVHIIQSAVEKKCLDGGAPFKFMHYTPRLGGWKRELPIMVHSLTETSVLYPDIPHSWLCDGRLLRLHDAHHKGNLQIFQEQWKRGQPVLVSLANKQMNLNLWKPDVFSREFGDIENEVVNCRTGNVIIGHTMSDFWDGFEVLGNRPVDDKQEPMLLKLKDWPPGDDFSELLPTRFQDLMKALPLPEYTHRNGKLNLASRLPDFSVRPDLGPKMYNAYGSSHFPKEGTTNLHLDISDAVNVMVYVGIPGDGPGGRKAQEDAAVKAIDDAGCDSITKRRVREVHEIPGALWHIYDAHDADKIRDFLNKVAKERGESIEKDHDAIHDQSWYLDKELCDRLLKEYGVQGYTIVQCLGDAIFIPAGAPHQVRNLHSCIKVAEDFVSPEHLNHCFRLTQEFRQLSETHSNHEDKLQVKNIVYHAVKDAIAVLREHDPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEQ7</accession>
    <name>A0ABM0JEQ7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101864510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_005092044.2">
        <property type="nucleotide sequence ID" value="XM_005091987.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864510"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005092044.2"/>
        </source>
    </evidence>
    <sequence length="576" mass="66117" checksum="BB17B21868D9C2BD" modified="2025-10-08" version="1">MPIFNEFLRRNSMAPNTKRVCVVGAGAAGLCAVKECLHQGLQPVGYEMDDDLGGVWRRAEEGEPVLKPMMYDNLVTNTTKWTMSYSDFPPLPQDTPIYTRKTLLAYYERYADHFNLRQYIVFNTRIMKIKRAPSYERTGQWLVHIALVDREGNPVEGQNMQTELFDCVIVCNGYFRSPRYPTNLPGRDTFPGFQEHSMTYRNNEKYRGKNVLVVGNKFSAIDIANDVANVASQTYLAVGSGTWIIPRLGVEGTIMDRAVSRKGLYSAPSIQHAFNEGLMAEANARLDHEATGVRSDVLPFNGPCSLQDSIQVKILSGQVIVYGYVTELNKREAVFDDGQRISDLDAVVYCTGYDSDFSFLDENVRPATHSEDGGVEMYKFTFPMTARHNTLAFVGHYGSDSAMLPPMELQCRLATRVMSGKYNLPAAPLLKKDVEYWNKISWSRKKSKRNPVVPLVHFSEEMAQVLGVYPHFWTLFFKDPRLAYRTWAGPWFPASYRLLGPDSTWEEARRTCHQMYEEDLSMVCHRKVKPLAREKVRRLSKYIWRGFYFLLVPCLLIWCKKRHPDFWFRLFIKTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGP5</accession>
    <name>A0ABM0JGP5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101852158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005093290.1">
        <property type="nucleotide sequence ID" value="XM_005093233.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852158"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005093290.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25641" checksum="56F36E2229DAF8D6" modified="2025-10-08" version="1">MNNKTLLKQGAEARLFKADFYGRPCIVKERFKKNYRHPTLDNTLTAQRLKSEVRANLRCRMAGILTPTVYMVNFENSSIYMELVDDAITVREHIAGVQEQDRSTANDVLKPLAVKIGQTLSKMHENNIIHGDLTTSNMLLKGEPSDVKLLLIDFGLSSFEASAEDKGVDLYVLERAFLSSHPNTQQLFDCILKSYRESTKNKKSCAEIISKLDEVRLRGRKRTMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH54</accession>
    <name>A0ABM0JH54_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box only protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093563.2">
        <property type="nucleotide sequence ID" value="XM_005093506.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855085"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46731">
        <property type="entry name" value="F-BOX ONLY PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46731:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005093563.2"/>
        </source>
    </evidence>
    <sequence length="519" mass="59267" checksum="A5F111E7231D396D" modified="2025-10-08" version="1">MAASTNAQQQHRTKLTEYLHSQAKPVHLESSVKRDSDRRAQRQSSSSKGLRNSQRTKPSLPNNKSQNISGHLRLPSIPKLPGNGRPRKATIESLPNEILSMIFWKLKIGDLIVASQVCRRWNFVACDNLLWKQYYAKFAGPVEKEKEASMPVHQLDSGCWKYLCLKRCKVKRDQIYLKKWKKPDSYTGLKQRPELSLGKVGVRFDLSFTDAQGVEHPMNQSDIFWMSMSCTIRWYDLVFPDFKDIHGLKIHACSPLMFYGPSKPAKDGIIQRSLLLELKGSLRNKMSGLKPLTSDNHIELYQLSSGFILGKYLAGGDIAFIATTFHYQNFVSRCLCGSADRSWAPPERVAFEDDIDSQYGLHGYTCILLLRNMRQKILECKFTDLYTRRESVANGFATFVPVKKDDKLTHCACLKDINFPWKTALFKGIMQNVCILDMTLLEESGEPFWTVSSLVEIQNSSETNQFDFDPNAYQSINYEDPTGKVHFEIGQLDDGLQYLCEAKISLSVPAINKYFRTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIL3</accession>
    <name>A0ABM0JIL3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859627</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094475.1">
        <property type="nucleotide sequence ID" value="XM_005094418.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859627"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094475.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="38861" checksum="5425813940BE0715" modified="2025-10-08" version="1">MSAPGAAMTHTSAEATSNSYMGKMWRYRNISYKLGIIGLVVSTGFFFLGFVSQRWLEARIYHDSDLSLTDVMLGSHEDWGYGVSDSYETISWGFFSGSFGNDICDSGCSVGLTVTRVLVCICFLSHILGYVVAAVENFRVVDVRTYHTHRLELAVLITGLLAGGSMVSFMYLFVPQLDHLVRLKYGWSTTVMWLSGTILFISCVFIVCGNRKPTVGVVVTQAGAVHMAHYTTTPSQVTVFQSGPAPQPQYPPMSQPQYQPVSQPQGPKFQPQYPPAQAPYPAPASQPLLPAHTAQYPLPNQPMGAPPAYSPAPAYPIGPTSPPVMMGYQPVPQAEGYAQASAPPPEPADTLPEKRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJC9</accession>
    <name>A0ABM0JJC9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phospholipase A2</fullName>
            <ecNumber evidence="2 7">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101853921</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal C2 domain associates with lipid membranes upon calcium binding.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="2 7"/>
    <dbReference type="RefSeq" id="XP_005094979.2">
        <property type="nucleotide sequence ID" value="XM_005094922.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853921"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="148"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="770"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="912"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="842"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="918"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="956"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005094979.2"/>
        </source>
    </evidence>
    <sequence length="1027" mass="117553" checksum="C6E51D4D53FAD9A6" modified="2025-10-08" version="1">MSNFRKKLPRSEPAFDPFQVFEVSHKTCVILHIKVVRGRKITKGWAQDLVDTPDPYIILNMTNSPHHWRKTSVKDNDINPVWEETFDFWLDPDQEHTLEMSLMDANYTADEHLASRSLSLTPLPVGQQIKKTIQFNETSEVDFEIWGEVKDQPSDLRFSLTLCKEEKNFLEVRKRKICKMMKEYYGFAAPRNYREVPVIGIIGSGGGFRAMTAFSGVFSALSEIGILDMATYVGGLSGSAWYLSQLYSHPEWPIISPKEQREEIQHNIDSNFMWLFKSHGLTFAKEVWKKRSRGEPVSFTDLFGHLVGNTLLKNRLDVKLSDQRVTVNEGLCPLPLYTCLHVKKCVSAMIFHEWMEFSPYEVGLPKYGTFMKSEEFACKFFMGNIVRRFPEPPLHFLQGIWGSAFCIQFKRLLQDDKNVDSTELMRREREELAEELEKDMQEYDAGDSESSDEEPMNEKGTHGEKTTGGLQRKRSKSTKLKQKTYWERLLARMMESSWFQTIELRAAQVFNFMRGLSLNNVFPFSPFTQTQEEEDENNKATFGSIFDLHPTDIKKLYVVDSGLTFNSPFPVMLRPQREVDIILSFDFSARPSDDTPPFKELLLAAKWAELNKVPFPPIDPTVVEREGLKECYVFKHPWDPNCPIVLHFCLININFKREIRPGLARRTQEELDFGNFSVFDDPARPYSTFKFTYTHQEFQRLSQLMEYNTLLCRDIIYDNIKVCIKRRRRFSIRRPCKKNDIARLSLNSRVKAEKLLEYINMVEAVNREAQKEDKDHIDGGAVKSARPSSSPVFFPEEGGRGGGGREGDDHDQVEIRNPKLQRSTVSLRANMRNRNKRLDLPNMDEVDEGVEEQDESSSDSSSSRHHPPANGKKTLSRSRPVSASMKASFDMASDKDDKHKIPAMIENLRIARKDTINDENGNTQNGSSSSERAKSPNLTQTTDNQAGSPHHAALPAESNGESSNSSNGKSNNNSGEAANSSNGRHERARNSFPDIVVMARKASADQTEHDVNPLEKWIDAAERVTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJQ4</accession>
    <name>A0ABM0JJQ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101861943</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095267.2">
        <property type="nucleotide sequence ID" value="XM_005095210.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861943"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046413584" evidence="1">
        <location>
            <begin position="25"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="192"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="536"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="678"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005095267.2"/>
        </source>
    </evidence>
    <sequence length="739" mass="80414" checksum="62F91C0C1F309108" modified="2025-10-08" version="1">MPSIRCIHVTLLVIIVTLTPACWGQQDTIDLTLVPRTHGQAVVDVAVSAIREKCIFADDFLFLRRLAYVKSKDGEDPNTYRNGFYGGIWQVSQADFQATQTANFLKGFPSKLPAAFGIDWSRVHWSDLQKPLYSGLAALFIILSKAGNMMPVSVTAQASLYSQSMGGDYTAYVNGVQELDRFYATCKAENLDIAFILDSSGSLAPSDFNLSKGFANGVVNSFNVAPDTVKVAVITFSSAVKEEFNFNRYTTTSSVGNAIMAISQLTGGTATDLALDYATNQLFTSASGSRPNAAKVAVIITDGVSRNFTLTSQAAAALKAKHVVVFAFGIGLGLYKPELSAMASAPECTHVKVLTQHSELVSVLSEMRRRSCDAATIIPTPSNATFKCGSPQTVKILPGDETTVRIQPSDGQIRVFGSFDITQPNEAKNFFDGVATAIRPLVLYLKATTAPLYLTLGAMSASADQCRGTVDVQTLVGNHLPKRGADTWCVVNRTLIECSCRLFLEKYVYREYAIVHGDVAYLSYPNPCKDDNVGSEDLCKSGSKGFHKYPFSIYHFVYCTGRHTLIEVDCPKGSYYLEEAGDCVLSTYIDRNNPCTACNLDNWYLGKLNHTIPWNRTQYVNCIYPGTCTVKSCGRYYIFDEIVQFCVPSGDGGAPPTTIGPTTTSTTTIPTTTRRTIAFTCESGPSAVNYYPYTFDPAQYIHCEPDGTAYLETCPAGTLWNQPTLSCMDPNKADGDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJS8</accession>
    <name>A0ABM0JJS8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Beta-1,4-mannosyltransferase egh</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7 8" type="primary">LOC101853452</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095315.1">
        <property type="nucleotide sequence ID" value="XM_005095258.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095317.1">
        <property type="nucleotide sequence ID" value="XM_005095260.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095319.1">
        <property type="nucleotide sequence ID" value="XM_005095262.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095320.1">
        <property type="nucleotide sequence ID" value="XM_005095263.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824839.1">
        <property type="nucleotide sequence ID" value="XM_035968946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853452"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="325"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005095317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005095319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005095320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035824839.1"/>
        </source>
    </evidence>
    <sequence length="603" mass="68305" checksum="54C5827A89799D9E" modified="2025-10-08" version="1">MTKFGELLGRNPDSSPSEERPIRQVLLIAIFFLLWHSERIHRQWRRFLDNCGLRLNNYLRRDPIGILWRSLSQAAVSVTTSLMQLISKRPVLVCWPRQLQNFFLLHWLVFAFSRTRHLLVGCISRVQGANWQYCLVQLAMTIVSAPAVRRLKHAMSVIALFGLIRLVGIIRGGVTGNDFNAIERYGLLVTLFIYFLQCLVFVPLPFFIFNFLGVVLLNVFTTKPKLKSCPSLSPFLCFRVVTRGLYPDLVNENVRHNIKICNNIGLQKYVFEVVTDIPINLEKQAQSREVVVPTEYKTSSGSLFKARALQYALEPEVDNLQAGDWIVHLDEETLLTEESVIGIINFAGAADYSFGQGVITYGHGQVVNWITTLADSVRVGIDYGCLRFSLGVLHKPIFSWKGSFIVADAEAEKDISFDHGPEASIAEDCFFACKAFSKGYSFGIVEGEMLEKSTFTLYDFIHQRHRWMHGILLTALSKKIPLRYKVGPVLMSLAGCTMPFNMLLFPISMIWPMPPSPVMYHIYTFVVGIIIYLFVLGTLQTFSIKQHGLIKCCLLVIATVLCGIIASVLENISSLRVYWIPKSSTNGFYVVNKQVQSECMKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK06</accession>
    <name>A0ABM0JK06_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC101856959</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
            <location evidence="5">Centromere</location>
            <location evidence="5">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095500.1">
        <property type="nucleotide sequence ID" value="XM_005095443.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856959"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008115">
        <property type="entry name" value="Septin7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01742">
        <property type="entry name" value="SEPTIN7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="19" id="KW-0137">Centromere</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15 20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="22">
        <location>
            <begin position="271"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="589"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="594"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_005095500.1"/>
        </source>
    </evidence>
    <sequence length="657" mass="73191" checksum="41918D6C9B0CCEF4" modified="2025-10-08" version="1">MSEHAGSPPPRGTAPPLPDKPPSVAERTRLLRSSFRKEDVDKPKVPEKPDNRTILASLAGQRSGGGGSPSPATLTSSVEGSSHSQLHQQQSGGGGAVTTSTTPPSHGLANGQSGSNPSLSAPTPSSGGGGHVISQKPPVPEKNASVALSAGGTAAHGDSNRDSESRLAGNLPPVVNTEAINAAKRDAFFRAGGDGPTTKFDPSARYGGGGGGGHDRERLLKKEETASHMSHNYEAEKERERKYGAETRKELEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSQEYPGPSHRIQKTVKVDTTQVTLKENGVQLRLTIVDTPGFGDAVDNSNCWAPVTDFIDSKYEEYLNAESRVNRSLSSDTRVHSCLYFIAPTGHGLKPLDVEFMKRLHDKVNIIPLIAKADTLTPDECREFKKTILNEIAQHKIRIYEFPDCEDEEEMKIQKRLRDRVPFAVVGSNRVIEVGGKRVRGRQYPWGIVEVENLEHNDFIALRNMVIRTHMQDLKDVTNNVHYENFRYNKLAPSTAEGNKVKPGSLTKDPLSQMAEERQEHNAKMKKMEAEMEQVFEMKVKEKRQKLKDSEADLQKRSEQMKKGLEQQQRELEDKWKDFEREKANWEEQWGERRRSLENQKDKKDKKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKK2</accession>
    <name>A0ABM0JKK2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger BED domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005095893.1">
        <property type="nucleotide sequence ID" value="XM_005095836.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848879"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1070">
        <property type="entry name" value="Zinc finger, BED domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005095893.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28969" checksum="3A1B1ACC5A90123F" modified="2025-10-08" version="1">MAQQHFQPSALDSNLATLAQASQAERPKTLVQQSFKTCIQKKMAYAVDSPRKHALDNLVAQFVVLDMQPFTVVEDRGFHTLMNAMDPRYSLPSRRELTRTLIPNLYREEYANLQKELNDAEFITLTTDDWTSWSTKGYMAVTAHFVDSQMQLKSKIIEIRRITSSQTADRIAEELRGIMSAWDITTKVFAIVTDNAANMIAAIKKLPVYHVPCFAHTLNIVVQDSLKNLRTLSSAREKVRAKVSHFNVSIPIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLJ9</accession>
    <name>A0ABM0JLJ9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101863097</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005096549.2">
        <property type="nucleotide sequence ID" value="XM_005096492.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863097"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005096549.2"/>
        </source>
    </evidence>
    <sequence length="607" mass="67508" checksum="7D26B34EBE8C5A98" modified="2025-10-08" version="1">MTSSFFVMKDTTFYLKLFYHENIKIYKDVNNKLGDSRRELAVTKVVNMEDKWNNLVVFAVTSYLVTKYILTRGMLWENIFLAAVFLTECFLLLILTRQNDLAVRQVKNYRPRCSSGVIFVVLVPLALLGTSGALGISNSSQDHETMFEMVWLSLSLSIVLVTKYFSEARVLCGLLPCFLILGFALPWIFSTPRQAVLMGIFNVIVWRGMDLIPSALPKSFTFGELAVVLQLIVSWACRLVSGVSEVYEIDEDDLKLMWFINTVLISVSTATLIVCLSGSYSSLVATSAVYVCHAGISLVFLHSQIREQPLLWLIGYIFKSCPRVMLLVIFILMLAFALIWTTVQGLQSQVQLRQSKPCDSDTPQMNSKTDKSTRRNGNDLLREVDEPSQESSRTIKGLDSNMEARRNNLIETRKIFHLFILLVYVPGLLLDPTFLLLSSGCVFGVFIILEASRALQVPLIGKLLDDVQRSFVDERDQGVVFLTHIYLLAGLSLPLWISPNVLTADLAPLELYSGVLALGIGDTIACIAGRAFGRIRWPGTKKTMEGTASSVLAQLAFVAVTSSSGLLTVESYTSVTVGIVLSGLVEAFTDQIDNLILPLVLYPFLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLL5</accession>
    <name>A0ABM0JLL5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Adenosine kinase</fullName>
            <shortName evidence="9">AK</shortName>
            <ecNumber evidence="3 9">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101847332</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="3 9"/>
    <dbReference type="RefSeq" id="XP_005096570.1">
        <property type="nucleotide sequence ID" value="XM_005096513.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847332"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="45"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005096570.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="37526" checksum="982149385BB28F1A" modified="2025-10-08" version="1">MASSSGVREGVLLGMGNPLLDISITGNQDLLSRYGLEPNNAVLATPEQHELFHEVVEKFSPSYIAGGATQNSVRVAQWLLQVPGATTFMGGVGNDRFRHILEENARCVGVNVCYQVYPDDKTGVCAAIITGEDRSLITELGAAERFCLDFLQKQENWALVEKARYFYIGGFLLSNSSDVVTAVAKHCSAAKKTLVMNLHATFLCQYFADPGLNLMPHVDVLFGNGDEYTEFARQMNMDMGDMAALALKVAALPKANSDLPRIVIITQGKAPTIVATEGRVEEIHVQPVDTSLIKDTNGCGDAFVGGFLSQLVQGKPLSECLRCGSYAAKIVIQHFGCTYPDHPDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JND7</accession>
    <name>A0ABM0JND7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101845920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097752.1">
        <property type="nucleotide sequence ID" value="XM_005097695.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845920"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21268">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21268:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005097752.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11278" checksum="9DBAEFDD063D0653" modified="2025-10-08" version="1">MPTLPIIYTPFTKLQAGWGTRQGSTCGEFEMDFVRCASRVGMNKAKFECLKEIEDFHECLWRSKQTQRTDIMEAERKRQKRPYIEPLGKDIPGKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPB9</accession>
    <name>A0ABM0JPB9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC101854082</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101854082</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005098383.2">
        <property type="nucleotide sequence ID" value="XM_005098326.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854082"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF75">
        <property type="entry name" value="RELAXIN FAMILY PEPTIDE RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005098383.2"/>
        </source>
    </evidence>
    <sequence length="379" mass="42201" checksum="4D76F70837EA388C" modified="2025-10-08" version="1">MNFSVSLQPLAETGGRLVSDSDFQIASYLFRVVINPVSLTAGFIGNILNIFVFVKIGVRDSMTASFLALSVTDLAYTSVSIVTTALNEVGFSRLHWPFPVIPFMLSGAISWYKFLFYDVTVYITTYISVARCCCVTMPLKFKDTFTVRRTVVILAIIAVGNTALRVPVLVSYGLAWRTSPFSNSSMIFIWYADHWSSVQALHDLGSQTILSNACLFIVLICMVILIFKLVQASRFRRSMQITPGHGRECVENSPSVPPPSPVPAHRNGMKSRDNNIRSTTPTILNARELQIVKAVVLVAGLLLVSVLYSSVQALARRLVPQFDNDGRYRWLFAISNDVRSSLSYVNAGANPFIYLRFNAKYRAVVTGWIRRGSPKVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPU5</accession>
    <name>A0ABM0JPU5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101849288</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098712.2">
        <property type="nucleotide sequence ID" value="XM_005098655.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849288"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098712.2"/>
        </source>
    </evidence>
    <sequence length="579" mass="65324" checksum="4F565D6D9E97A855" modified="2025-10-08" version="1">MASYGRKMLEAALSKNAQPESSRPYSTRSVRPPTAKVDCQDKVKEWLHLSFCCPEEGVLEEMDCGSSSHSEYEPFTSGSESESGEAFPASEKAIPEEEDVPESVVSQEQSEIFPMLQGIRDLPSVGPDRQQSDDVEPLECPPENDALEVTAPSQSQLRKAFAKVKIAGDPKSGSKRNYRKPDYCVFCKGMYVSKISAHYLSVHSKEAKVKDIVSLPIGSKERKRLMILLQNAGNHEHNCEVLRNGCGEITVSRRPTTQETSRPELYLPCTECKAWVFEKSLSLHSKTCPAGKNSDKNFLRNSRMLLSPFLQLDSDEGEIEDIISKMKETSKNPGLRQICMHDVLIREFCRGLVHKLGPLEEQRRKDKDNIRTKVRAVGRLVVRLNEKSNQDLDLSAFLKPTHFRLIVETVRDMGLESPNLSLTLGHYIKQIVQLKQSLALQGEDDEARKDADNFSLLIGAHWNNYVSAVALRRMTLNKAVELPKTTDMVSLKNFLDQEIKKSLSLAKLSPQEWTDTAEVVMVRILLFNKRRVSEVEQLKVSDIRQIQTDSDNEEMLAQMGITERTLAKRMSVVERLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPZ9</accession>
    <name>A0ABM0JPZ9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101856735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005098831.1">
        <property type="nucleotide sequence ID" value="XM_005098774.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856735"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044977952" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005098831.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="63474" checksum="9DEBC4C87A945DD5" modified="2025-10-08" version="1">MAAIWLLQVLFTSALGASCLHRGQRAADDGFLMVNTSYGTLRGKVDSTPSVPVAKFLGIPYAKPPTGPLRFKAPVSPDSWDGVRDALTFGDECLQKLSPNFPFRAGDMPPKRSEDCLSLNVYSPTQRNVQDLLPVMVWIHGGGYYYGAGSWYDVTDLATKGVVLVTINYRLNIFGFLSTEDDTMPGNYGMLDQIAALKWIKDNIASFGGDPNLVTIIGQSAGSASASLLTLSPLAKGLFKRAIMESGVSLTTWAFIYPGNRLSHRMASRLVGQAAQCGDLDNSTTFFSCLQKVDANKLLNISLDLANILEPRQKVFAPRVETTFGFMPEFPATLLSRGQINHVDTLRGFNSDDMGIYDPRFLKNPPIPVTAEVAKHVIVRQMTQFTKLDQGKLLKVFQSKFLTNTSSSDVLQREALNAITTYTYVGPTIMELNYVVRSVTDKKHYLYQFNHRPSFSKLPQWMSAVHGQEIFYLFDVQQKRFTDTGNGPPDADDILVSQQIMERWTNFAKTGNPTSTVPTGGATWSQYSSATPNYLLINSDSESRLWAKPYVVDLSRKVLETFGGISPAPVDPIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ07</accession>
    <name>A0ABM0JQ07_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101859639</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098844.1">
        <property type="nucleotide sequence ID" value="XM_005098787.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859639"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF3">
        <property type="entry name" value="RING-CH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="223"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="325"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005098844.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49592" checksum="86333A2690C6371B" modified="2025-10-08" version="1">MPASSSAGSASASRKKKEDVAEKVREIKQRQQNWLKQREQTKHSDELGAKSKVQQNGSQVKLVRPQKVPSGKKTQQNLPASSSNISSNKTTSDVKDKFKLWRTARAQRQPSKDDGDFNDCTSIRSGAESELERLISPELETVRQPVAEENFDDLANQIAERVKGDLGLEQNGLHLSPIPSAAYHTDGESSNDHTWNSSRCKTFTREVPTFNHLGTSGLTSHTCTVCKKLMLSSSHIPMMVIPCGHTLCKSCSEGRSYCPSCDCPVVSLTVNIMLQQVIQEYHAHPKASSSHNNDTQDEITVDIVSPGGRNYSPGKYVEDNRRNRMASYKKQLVSLQTRHEVLSNEHDSLSEKREKVNKSLHHEQTQVQNIRKQEEEVSRSISELQERLGALQEHRQQYEVKVSELQDESSEVDGKVHLLSSTLASLNREIEKVKLLAEGEADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQW9</accession>
    <name>A0ABM0JQW9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mitoferrin-2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101860818</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099446.1">
        <property type="nucleotide sequence ID" value="XM_005099389.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860818"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF20">
        <property type="entry name" value="MITOFERRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="110"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="201"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005099446.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35476" checksum="C27EB0693231EBB0" modified="2025-10-08" version="1">MEEDDNPYETLDPSSSMATHMLAGAAAGIMEHTVMYPVDCVKTRMQCLVPDPKADYRSVADALRKIVRHEGVRNTVRGFSAMAIGAGPAHALYFACYEKFKHVLSGGKQGNHFAHGCAGCAATLLHDAVMNPADVVKQRMQMYGSPYQSTFLCFRDILRTEGAVAFYRSYTTQLSMNIPFQATQFIMYEIMQDYLNHDRNYDPSSHIVAGAVAGAVAAGITMPLDVCKTLLNTQEHCARTHLTYISGMASAFRTVYEFCGISGFFRGLTARVIYQMPSTAISWSVYEFFKYIISQQRKQPDDRYLSSVHIAAATASPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRC1</accession>
    <name>A0ABM0JRC1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thrombospondin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099723.2">
        <property type="nucleotide sequence ID" value="XM_005099666.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847877"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046335757" evidence="4">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005099723.2"/>
        </source>
    </evidence>
    <sequence length="231" mass="25746" checksum="E0F75826ABF6AA25" modified="2025-10-08" version="1">MWLQVRTLAVVSLVLLVERSAGQRSKGQWGEWSRITPCSVTCGSGTQKKVRVWIPGPGEPARKEPYTSSHMFTCRPDKYPHCPTDGHWSEWWYWSDCTRMCGGGTRHRERECVGVTYNGKECDGEPRSEEKCNREPCPPLPRHFDMRQCVDTQNYTCASGKMCVPSKERCDGDVHCHDGSDEQNCPRAVPGPGRVRYGLSMGRNGVAYVQGSAAVVMASVFTITAAVSLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSF0</accession>
    <name>A0ABM0JSF0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101858864</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100449.1">
        <property type="nucleotide sequence ID" value="XM_005100392.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858864"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005100449.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="63940" checksum="F7A055636FB60D4E" modified="2025-10-08" version="1">MSSLAFVTHPSVRIKGTENSYTPTQCLDELCPVKAPHLHCPFCVKSDAYQDPVILKAHYRVKHVDKGIDFAGLKILRCCDQCDIIGIIKGEKRFKGAHWHCYRCRNGFNRRDEAIKHYKTHFRNPQTTFQIQITQDLNSPPIIRTPSEDRTGTTQDSFASIENPVQEIIHPALTETLSLSETNVMTTDTGTNGKLQKVKVKHEPLDKDLSSGDHEDQQTIMIIQGDQLESALASHIINSGELSVLNKANLDPSISWEIRFRMEEEEKNMYKAKAQEYKVQVELLQQQVSELQSQVAQQSELKLQDFIDSLSAGDIHKQALGVQLAKFMEQMQSSQNSENSSESLPAAEHLHSNTSLVELTNSAASLQHLESNATMTQLSGIPEGYQVITTTPEGHVIVGKAPSPSLTPEDSISVIADDSNIGDNSISNITPSSVPETPSVVNPQKQPEQEVLIEGDVLSESMNAPPSQPLMGEGEVHSTDLTVLSEIATSEDSLLHAVASDEERVSLNTNVTVVAPVDSGQSGQEAYMMDIVDGNRILIKGTVDGEPVQTVMGHEVTQVTSNQKAVSEETAEPEAKRIRVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSS4</accession>
    <name>A0ABM0JSS4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">17-beta-hydroxysteroid dehydrogenase 14 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101848050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100663.2">
        <property type="nucleotide sequence ID" value="XM_005100606.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848050"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100663.2"/>
        </source>
    </evidence>
    <sequence length="273" mass="29415" checksum="046F5D9E8C7A0425" modified="2025-10-08" version="1">MASAMLAANSQRYQGKVTIVTGGSAGIGFGVVSVFVQHGAKVVFCDLKSKEDEGKAKAVELNAKGPGECIFFCCDMTVESQIKDLIGFTVSQYGQIDCVVNNAGAHPPHKPIDDFSAEDLENLHRLNVTGYYLMSKYSLPHLRKTQGNIINNCSLVAQISQREAVPYVTTKGAVLSMTKALALDEAENNVRVNSFSPGNVLTPMWEQAAIASGNYDEAIEIGRNEQPMGRYGTIEECGLLCLFLATDATFCTGININITGGAELGYGRKTRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTB6</accession>
    <name>A0ABM0JTB6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Ankyrin repeat domain-containing protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101846145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100995.1">
        <property type="nucleotide sequence ID" value="XM_005100938.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826313.1">
        <property type="nucleotide sequence ID" value="XM_035970420.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846145"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="556"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005100995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826313.1"/>
        </source>
    </evidence>
    <sequence length="610" mass="67132" checksum="17817E8A725509E5" modified="2025-10-08" version="1">MDDIIKQDDYRELQTQLALHKDGSTQWNNLESLMFSCCGHGAANCVAILLELGVDKDCMDEQRMTPLMHAVKSGSVEVAKLLITWGCQINALGGVEGHSALHLAAVNGYLELCEMLVQAGANVNVKNEKEDTPLIVASVFGHLPVVKHLLNCHASINCRGYHECSALHEATEHGHYELCSYLIAAKAGLEDEDTFGNTPLICAAEKGHVNLVLLYLAQGADVNRVSHSGTTALHYAAKEGWTSCCKVLLHHGAEIDAQDIRRFTPLMMAALEGHENVLKLMLDAKCNVNMAAYNRRTALHYAAERGYSSCCRLLIHSGAWVEGLDADLCSPVMLAAWKGNVETTRLLLDYGSTLNRWSRLGLSILHLAAESGSTECCELLLEQGMDINIRGCENIMPVISAIRCHRMSAIRFFISKGCAMGKKTEDTHTVLNEAIFRDIDFDVIEKMLARGASPNTVDANSTLPLWHAVDSCNFPVIKLLLQCNSEYSVKTQSVLVPCSPCSPISHAIHRENPTLIQWLVAAYSEDVARLLRGTECQYSSPSGSSHLLSLVRDLVKQPQSLLRQCRRAIRKQLGCGYVVNQKVCKLKLPTLLHNYMLFSDLDPPSDLDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTF6</accession>
    <name>A0ABM0JTF6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101864156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101070.1">
        <property type="nucleotide sequence ID" value="XM_005101013.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864156"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14605">
        <property type="entry name" value="Nup35_RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="679"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="973"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1271"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1175"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1316"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005101070.1"/>
        </source>
    </evidence>
    <sequence length="1342" mass="147866" checksum="90F48AAC6FD82E5B" modified="2025-10-08" version="1">MILDQVEALKVWLTNKLSPICDAEPIALAKYVCALLKKNKPEQDLKDICIDQLDVFLQLKTKPFVDELFEALHSKAYIPPESETNKPRPASVAASKNDKSPAQGGEKDKVDGPRKKSTEQISSSTDGKDTSSVVTTQASSTPSTVTAASGTKDTALFPHLAKDSTKEPSKDSRDAGPRSGSKEGRDKDRDRDVDSSRDRRDSWRDEKKQNDIRDARDIIRERGENRDKGDTREVREPRDREVRDRDRDRDFRRRRTRSRSFSPRRRDYDDRRRRYDERPRYSPDRRWGRRRSWSRSPRRNRSPLDRGPRARSRSPRLRSRSPRLDRYRSFRSRSRSRSPRPARSWSRPPSANRFRSRSPSNIRQPDSRGSTPTQDNDYSTLISSSTNDLPAVTSTVGLRPVGEDGRMVPVVDDARRPPPSVTVGGKARCQDFEEKGYCVLGDVCPYDHGSDPVVVEDVSIPGTLPVSTASGASAPPGGPGFVPPDLRVPPPGHLGMRINIRGAPPPHVEPYMPEAPGLQGPPRPPFLRGPVPDLRHPPPGMILNRPPPPDQFFPQRREVVLNNRLEPALEEDLLDTLASEKEPSRIVIPAKRPYSAIDNDPSSVHLGPPPPRMAHVNQHHHMFAGPPPPMVQKPPMLQQPLPVPLGPPPMKRGFDFNRLGNRGGFRPQGPRQPFKTGNLTLEVRKIPAEMNNIAKLNEHFGKFGTLTNIQVKYQGDTGAALISFSNNGEATAAYRSPEPVFNNRFIKLFWHNPERAAEFDMEKEVGGAGGAKEARDVLMQSTTRTGGRVGDGIDHPSLMLPVRPTIPPAHKLQLDNTKPKAEPASLTAAGDMATPTSAPAEKSIVYTSSVGNLKKTVFNPSAAVPSPTSPTAAAAKGPAPFISPTAVKTADYVSRMEAIKRAEEEKKVATVKQAELDQKRQELLAKQIQHQKVLLDALDKKKATMSETEKKSMLQTLRTISDAIDKVKYGTGTKKPATSAHQAPKPAQFKYVSQEQNRKEQLDRELDVLSKQKRGEDVSTFRAAPAPYGRGRGWAGGRGGWGVRGRGRGVGPVVGRTYLDNRPKTLEVKGFELHELEEVTAHFQKFGEIDKVDPKEEVPSAFFTFSTRQAAEMAVSQGAKFNQKTLVVRWNQVTPKIDRTESTQSSEVDEDLSITLGSLDDESLLGMSGDEKSRTGTPTLSIGSQQEAVPQDADLDTGLDSLAGDSRAVIEENAGTVAAEVGMGKEKSSTTVSYMRSMSDDLLLGDEHFKASYTDDEEDEEDHITVTLSNTTTPGTAMPLYAGGNTGGVGGREDERDVTELGGGEEGEDVFGAVGGEEEDEEDLANLEDTALDYTEDAGSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTN1</accession>
    <name>A0ABM0JTN1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101863195</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101863195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101231.1">
        <property type="nucleotide sequence ID" value="XM_005101174.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863195"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="11"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="630"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="892"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1032"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="918"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1058"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005101231.1"/>
        </source>
    </evidence>
    <sequence length="1068" mass="117020" checksum="43B94B6DF1FFAC29" modified="2025-10-08" version="1">MTSHRIGVNLRVSGNCDQGARKYMEDNHVIKFLKKDTDDYEFAYFGIFDGHGGPEASAFCRDNLLNEITKYDGFWTDDDEQVLSAIRKGFLDTHNAMWNVLDTWPKTVTGLPSTAGSTATVAIIKQGKLYTGHVGDSGLVLGENDAYATDQFPVQAICVTKEHKPDDPDERLRIEDAGGEVINKSGVPRVVWSRPKTNHKGPIRRSTQIDQIPFLAVARSLGDLWSYDYYTETYVVSPDPDVAVLRLDPTKHRCLILASDGLWNMLTPEETVNMVMDLETQFEQRIINDPNVAVSFWSNPAERLVARALNKWRSKALKADNTSCVVVLVDPLGPSKLTLLKRKRQELLSGGEITPSQINKFSSLPTTSQIKTLATTKTPAETDAMGKHHNRNANCSLSDSHLRITDDSMIQGLDEQDPQGGSTVTKRSYGGQRASYNPGNESVNDSIQFIPEDKPWNLRHSLRKSESGNMSHNASSLRHETSMMKKMHPSSHPPVSRMDTSHGPERFRRGDDSVFTRLVDSKVTSGIPGDREILKDLKRGKASHKYDSSFSAHKNVMSRLIVDEHMGGFDEDVEIEKDSDSEDDEDSIPQPPPSTPCSSEEKAVGGGESDGENSLHSSADVTDLAFSLASDESLESPETSVEERPRTPLSAPAKLSSSRSRRHQISRSAKRKLVVRPGKKVNILKQAAGTKSRSTAASSPLFKVPLNPQKSTGVSSPLTRTSLSLKSSQKVTSKNASTCTSGSRITAEGSSKFQSPPKQVLNMSKSMNEVTPKNKKDAVSSVSCTGLTPDMSLLLTEKRAVGHPAGSVKDISTHYYPILTSNKLDSDCSSTLRSKDDNFMVVDDPDPTTMPSVNPSEPLKQLNKTGPIRKSGSKRWGNFLRASKLGLDNIFHHGSKKGSDNKRTSVSTGKLETELQRAAKVSSTSAKNSSMSTSRLGDLSLVHLPDVTVSHLADVTVDASTLDDGDLTTLSALSAEDSLLSAAVLGRDPAGHHSMLEEGPAGKATKHRKGFLQKTRFTLSRARKAAKKAFFPENHRLFNHKSAGKKRKSDEFLPSPSLKKRRHVEADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUD5</accession>
    <name>A0ABM0JUD5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 17 member 9 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005101701.3">
        <property type="nucleotide sequence ID" value="XM_005101644.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854263"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF279">
        <property type="entry name" value="VOLTAGE-GATED PURINE NUCLEOTIDE UNIPORTER SLC17A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="38"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005101701.3"/>
        </source>
    </evidence>
    <sequence length="453" mass="50357" checksum="784A47FFE9D437D7" modified="2025-10-08" version="1">MAERVVNVDVYDKECKVLLKDKRNSSGKFWTRSEKKQWVVGLMLGTSMLYAARTIMPLCIVSTSQELGWDKTESGTVLSSFFWGYTMTQFLGGYLSDRIGGDIVLPIAACMWSLITFWTPQLAYLSTDKHISLYIVVLSRVSLGICQGFHYPGMTSIISRKVNEQERSLTYSMVASGSHIGTLLTGSVGSILMDRYGWQFPFYFIGLCGLTWMLLMRYMLIARQRNKSVVVSLADAPLPDLATSKDKPETRSSVPWILLFTKPAFWSLLVGHFCENNAFYILLSWMPTYFHENFPTAKGWVFNVVPWVVTIPSSIGSGWLADKMISSGYSVTFVRKFMESVALLGTAFFLFIISYTSSYTSCLICLALAVACCGFHNSGILVNPQDIAPKHAGSVFGIMNMAGAIPGFVGVYIAGHILETTKSWNAVFGQTSVVCVFGWIVYVIFGTGRRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWE8</accession>
    <name>A0ABM0JWE8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101859498</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101859498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005103112.1">
        <property type="nucleotide sequence ID" value="XM_005103055.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859498"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005103112.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25262" checksum="ED91EFE047C57D6F" modified="2025-10-08" version="1">MERCLCIIAPLHVHRIFTQKKTAICLAATLFLVLLSLLPIFAYSSLAPIFDPGKNKTLIGIVYNDNEDAIEQFVMVTGVIVTAGSVLFVYVFSVILVYALIQRRRKWESSKNKATSQTGAARSQGNTPKQSKDIQVAKMVLLIAAVFLITFMPNGAMFLAIELVHEFFLDRAYHNVHVVCVSFMQVLQGINSSINIVLYIKMSSKFRRIFKALFLSLKQTEPILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ10</accession>
    <name>A0ABM0JZ10_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101853251 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104882.1">
        <property type="nucleotide sequence ID" value="XM_005104825.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853251"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="823"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="958"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1116"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
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        <location>
            <begin position="864"/>
            <end position="891"/>
        </location>
    </feature>
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        <location>
            <begin position="958"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1012"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1116"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005104882.1"/>
        </source>
    </evidence>
    <sequence length="1319" mass="144550" checksum="7107B61CAF37CAAD" modified="2025-10-08" version="1">MENIMLDTPKKNIKLVDFGLSNTFAKDELMKTHCGSPEYAAPELFTAGEKYGLEIDVWSLGVVMYAMLVGKLPFTTPYTDQYRRQKLVQQMEKGLVEVHNQEMMHLSVDCQDLLHKVIEPSPSIRLPLLDMEIHSWLTENGKKPFVPFQSFPRDKNMKSQSCLLQDSISSADDDEAIEELAVALNMKKEVVDQKVAENKSDEMSAMFNMILDRKRQQQGVFDVDHTLKNEKKEQRAKRSKSAHARSGDKKHVTPPALLLPSDDMNMESAPHSGNEQDHETKFSSFDFLALCSTPTWLGPERRKSRRRSRSPMPSPHLQQHGTQGLSVRNQMKRDYMERQAIEMEREMIREEKAAAAALLSPNSAGQAGAQSQQQQNANEHTPVAASLSVPGTDPPAHSQLAFRRSSSFKLSRRRAKSCGPSHKRKSSFQRSGSVDHSAQKVDISSAKELASSLATTKEGSSAPVITGEIFGQTAEAKTGKTKRTSSLRRKLSVDTTVFANKNLLGVPSFDSHGKNHLTVPSEESPIGINLLSVPSVCSDSTQHLKVPEVEIGFQNSLSVQSPGTPNSPSEDSTSSLNGGKANSIPRPGKLILKECYPPKDNNRSKSNSHIIPVKPLISGANGPLTSVEVHYADCSNPNSSTDLLQPTSNSSLKADSLEVPRASAEGLSDFSDSFYLSQSELKGNDRLSSKQMLDSQAQKQDSFHPKLSSESLQPIASSQHTKNLMPNSNHLTISSCMEDGAIAMQIEDKSSSLCAFNENRVLLGAECPPFRCDPSGNEEVSDLQNHFDGLMMSSDCMEESDDHVDSMTELISDSFRHTILANAKPSASPGHNSIGVGASPKYGHQNSAPSPEEERALSKNSSRKGSGSIASFSRSSRSGSGRKSGSGKVKSPTTPNWMVLKTPLARIESFHSDDFECLADSDIDDRPCSSDSPMSVTTPTVPCFAYKLHMMKKKQTKLKNNNANNSGPLSKADHASSKMNRNSTEKKHASTGSGSTRVDATIMEPLLSSGSETEHQDEGQDRLGAPGKSKIHPMVPDDKDLELLSKSDTKCLPYTNAITRQPNQIKNSVNKCHKITPDPDQSGKKKTFVKNLAWKKSFAQFLKRKRYHSPIATTTQPQQQLPLGHQPQQQQQQQQQQPLVHQVQQHQHIQHQPAGNNNNNELLAPDPQPVSRNGMSVLVQQPAKLADASTGAEDPLLGPHEGENCKIHTTTFTSAPVESTMTELIELQSSPKPHCSPSPVAGRVFDFTLASDSPKIKSSCLLGWGSCRDCGRGEVSEEEDIECFSSHDPAVVNLSLKPLGETNVQENTSFTQTYSFSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZN7</accession>
    <name>A0ABM0JZN7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">5-hydroxytryptamine receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101851213</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005105301.1">
        <property type="nucleotide sequence ID" value="XM_005105244.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851213"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15065">
        <property type="entry name" value="7tmA_Ap5-HTB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="53"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005105301.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="51616" checksum="145694A2FFCBFA17" modified="2025-10-08" version="1">MESLTTLTHEVPHPENVVWAPPAYDEQHHLFFSHGPVLIGIVGSLIITVAMVGNVLVCLAIFTEPILSHSRSNFFIVSLAVADLLLALLVMTFALVNDLYGYWLFGETVCFIWMSADVMCETASIFSICAISYDRLKQVQKPLHYEEFMTTTRALLIIACLWICSFVGSFVPIFLEWHERSVEEIKANFKGSGSDKDRVKKKAAEAQTFSPTSNQSSGAVQKLNTKPECLFDVHFTCSVIYSFICFYIPCTIMLTNYFRLFLIARKHRHRINSIKPQVNGGVQQPRSQRTSFNRKCGVRGSKAARTLTIITGTFLACWLPFFIINPIAAIDEHLIPLEYFMVTIWLGYFNSCVNPIIYGTSNSKFRAAFKRLLGCRSVRGNVRGFSPRRSIYRAFSWIQPSRLDFTPSRRCSRTVSCSFHSDTREVDKNSDGGNSVKAEPSKSEVIITEQESSYNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K061</accession>
    <name>A0ABM0K061_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101851819</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101851819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005105655.1">
        <property type="nucleotide sequence ID" value="XM_005105598.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851819"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005105655.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20705" checksum="D14BB9093D212BDC" modified="2025-10-08" version="1">MTCLRSYLDASKWAKIALTLLMVNTSMAWNSFVSATWGDGYTTGPVFVGYGLWRRCGNSETAPNCVNLLGWNLQWYRTVQAFAIMAFVCVNVCYLLMILLVFLNRCKGSKAISLWICVLSFFSALCYLVAVTVFAASFDDDFTVTGASSTSLAFGWIMTIIVALVQVLVGVFMILEARRMGAKVMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0P5</accession>
    <name>A0ABM0K0P5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor 3B subunit 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106000.1">
        <property type="nucleotide sequence ID" value="XM_005105943.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851821"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="828"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106000.1"/>
        </source>
    </evidence>
    <sequence length="1120" mass="122545" checksum="C60B25A5DC4F2C0E" modified="2025-10-08" version="1">MDGGPDNPGSRRDDDHPPWQQMSMQRDQGEGGMQGQQDISEDLMMKVRQHQQLLDMEKKREAQQKLMEQQQLAMLEAQRNEQQRILPPGSGQSLAPAGLPTTPSIRSSGVSMVSAPLRPPGMGNQPPQGSMPNQQQQMMQGGPPPLMGQQNPQGGPPGSQGGPPPPPHILQGGPQHMGQGGPPRPLQQMGDRPPMQQGGPQMPQGGPPMSQGGPMMSQGGPPRQQGGPQMSQGGPQMSQGGPPMQQGGPPMQQGGPPRQMQQMGDRPPMAQGGPQMSQGGPQRPMQQMGDRPPMSSQGGPHMPPGGPQMSQGGPPMSQGGPLMQQGGPPQMSQGGPPQMSQGGPRGMQQGGPPHMQQGGPPQMPQGGPRGMQQGGPPMSQSGPHGPQGGPPGGPPMSQGGRPMPHGGPPMSQQHSDRPHPHPPPLMSQNMRPPGPNKDGMGPPPLGPPSDGGPRPRMARTPYNGPSIPPNVVPKPGGPPPSQGPKEMRLPQALEKMLEFKSLRESEIGAELDGEKEDEDEQGSDDEKRGTNENDKDEVNEEDENEDEEVGTISKDQSKETKNKRKKKKKKKARRNRFEQQKKPKKKDKKSKASDVVVEYIQEQPELDPTDPNYHTFARIFEAFKITEPEKPKEVKVEEAEEVKPKEEPPMKVKGLLDDDDDDDDDLMANDDDGPKISKKKLKKLTRLTVAQLKQLVTRPDVVEMHDVTARDPRLLVHLKATRNSVPVPRHWCYKRKYLQGKRGIEKTPFELPDFIKATGIEEMRAALQEKEDQKTLKSKMREKVRPKMGKIDIDYQKLHDAFFRFQTKPKMTVHGDLYYEAKEFETKLREKKPGNLSDDLKMALGMPVGSNSEKVPPPWLIAMQRYGPPPSYPNLKVAGLNAPIPEGCMFGYHAGGWGKPPVDEHGKPLYGDVFGTQNADYKAEVEEDEIDRTVWGELESESESEEESEEEEEEDEKDETGLITPAEGLMTPGGISSVPVGMETPDQIELRKRRIEDAMDQGGDTPALYQVLPEKKAAPVGGAMMGSAHVYDMTGVNAPKKPGDKVSTEAVEVSLNPEELDLDTAAMQAKYEQTVREQQSQLEKEDLSDMVAAHAAKQRKRKKAQQDTGKGAKKYKDFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0R5</accession>
    <name>A0ABM0K0R5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101862672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106042.1">
        <property type="nucleotide sequence ID" value="XM_005105985.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012942241.1">
        <property type="nucleotide sequence ID" value="XM_013086787.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862672"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005106042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012942241.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="57726" checksum="D00975ABFDC392FA" modified="2025-10-08" version="1">MSTENGTSAQASRIGAYKNKGRDIEDLRRRRAETSVELRKQKKEETLLKRRNVEILDDEPTSPLQEHNKPAIMPLNEIVTSIKSTDHYVVFNATQSVRKLLSKERNPPIDRVIEAGLVEALVNFLYSNDKPDLQFEAAWALTNIASGTSIQTQAVVRAGAVPHFIRLLTSQSMNLVEQCIWALGNIAGDGAELRDLVTSSGIVEPLISLLDMSAPPAFLRNLTWTFSNLCRNKNPPPKMKAIKSVLPALSALIQHADKEVLADGCWAFSYITDGANIQIQEIVDRPGVLQRLVELLGCVDAAVVTPALRTVGNIVTGTDEQTQAVIDTNVLKMLPSLLQHPKASIKKEACWMLSNITAGSVEQIQAVLDHELMPLLANVLATGDFKSQKEAVWAVTNLTSGGSVVQISKVVENGALQPMCDLLCCKDSKLLLVILDGIRNILEAADKCEQLEPMTLMLEEIGGLDKVEMLQNHENKQIYTKAHGIIDEFFATEDEDSELAPQSDANSSQFQFHTDVQTHSEFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0S8</accession>
    <name>A0ABM0K0S8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Negative elongation factor E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101847988</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM NELF-E family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106068.1">
        <property type="nucleotide sequence ID" value="XM_005106011.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847988"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12305">
        <property type="entry name" value="RRM_NELFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033102">
        <property type="entry name" value="NELFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034637">
        <property type="entry name" value="NELFE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="15" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="163"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005106068.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30797" checksum="DC011AD6FB245906" modified="2025-10-08" version="1">MLIHFPNALTEEEETLKQAFAKLKKKKKMVQAMKAAAHNQEKEAVHNKSASKPAASSSIDSADKATEQAKKLVQSGAIKVASLKEKSGFKRSKTLERKKDSEKPAAGMGFQPFMSFTGEEEEDKPPSSKRIKGLNETFVSAGYGNRSYDRPEREHRDPPKKGNTIYVHGVGITEDMLKKSFSNFGKIVNISMETERNKAFITFEKMEAADQAIAEVNGSMVNNTQLRVQMARHQPSFDSLGDASSTASWASIAASNSQKGTTHKDKRGMVQYDHDDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1Q0</accession>
    <name>A0ABM0K1Q0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106680.2">
        <property type="nucleotide sequence ID" value="XM_005106623.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850904"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106680.2"/>
        </source>
    </evidence>
    <sequence length="206" mass="22792" checksum="21024E7919387AFE" modified="2025-10-08" version="1">MADASLKLIYFKGKGRAEMARLLLAAAGKQYEDARLSQDEWKEQFKQRSPFGGAPCLEVNGKMYGQSMAVSTFLAKEFGFYGSSNTDGLVIDGVLQSIQDIMQIAVKFMFEKDEGKKQELATAFKDTETPRFFGYYEALLKENGTGYFVGSKLSLADIAVYDLFTGMMAPRLGSVDSFPLLKALVDKVGADQKIKAYMASRPDTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K280</accession>
    <name>A0ABM0K280_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LIM domain kinase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005107011.1">
        <property type="nucleotide sequence ID" value="XM_005106954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845951"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF550">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005107011.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22053" checksum="A2089C16D0FFB6BA" modified="2025-10-08" version="1">MDAIEQHDTFFNSFNLVRGPCLGSGALGEVVLASAKHNSSLKVAVKIVSFETEECESDFLFEVGFLRDLRHPRILKMIAFAMDDHYGFMLSTYFQNGTLRDTMSSDPPMEKPRILRHILDVASALQYIHGLHIFHQDLDMYSLGVSMWMLVYRQRSEGIKGLLAFSDHCKDVKEPYRRILRQLLRKDPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2M8</accession>
    <name>A0ABM0K2M8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gamma-glutamylcyclotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101845195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107342.1">
        <property type="nucleotide sequence ID" value="XM_005107285.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845195"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="TROPONIN C-AKIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="38"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107342.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22004" checksum="E169B08FB890670C" modified="2025-10-08" version="1">MTTRPESDASAGESSANLTENPTPDHALDPNTHPHLAFVYGTLKTTEPNHRHMFAKGAAGSQLVGRARTVEKFPLIVATPYNVPFLLLKEGTGNQITGELYRVNDETLAYLDWFEDHPAWYLRTKCQVTLLDEVKAEPVECWIYGLPKFKKSLLDLPFLEVYHDNLREEHERFRHVDDRAIDQIKQTLCDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3B6</accession>
    <name>A0ABM0K3B6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WAG22 antigen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107795.2">
        <property type="nucleotide sequence ID" value="XM_005107738.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851147"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="974"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107795.2"/>
        </source>
    </evidence>
    <sequence length="1243" mass="120106" checksum="54701F9B5424EBB4" modified="2025-10-08" version="1">MAAAIIDKARGLSVISRTPDNEDQPLQRDIEYSHFIGTNIGNIPPAAEKPYTYLSNQPLYPTDQEQYTGPSRFDNSHTVNEKTESKNTEPSSPVQRQNSPVHWQAKNEVSRHRRDTARSPISAVAGVFRNSFRQPRGGADSAIGEWNVNNPDKRFLVREGGFRSASSPASSSSPASSSSSSSSQFGDWWDNDAWGKGSEGDTSAWFLQPSQKTPSVDSGTASVSGDSGTSAWGQGEPSISLPVSSSSSSSSSSSSSSSSSNPWGASSGTSSSSSQLGSFSYSLWKNVSAQQLTQGSSGGTAQMATFGGSSSAGNGNVNSGGFSTNGFTGQGQGGGGGGGGGSSSSFVQPQGGDVTNGFLQGGGSSSSLNGMFSFGMSGFDGSSGTNANSGGMTSASGAAGNGAEGFSGSGAQGFANVGAANGAGGMDNGQQGNSVPGIGQGSNSFSGTSGAAGSSGSSFGGQMGSGGGGGGMFGMAPGFGGSQGNTGDNAAGLFFKFEQAQNSLGSKSGAGFGEAQGVGGAASAGVASNAGNQGGTGGGGSFPMQGSGSSSGGSSSPWGSSSSGGGAGSNAMGQAASMMTSNVQFQFNGGLSENNDAWKFSGMTNPGFSSPGFGGSQNTDGRGAGGGMGGMGGMGGMGGTGGSGFGNTDGGMFSFSGSPGFGGSQGSVGGGTGFGGQQGMGGGGGGGGLSGFNMGGGSSNGGGVDMGMGVASNLGGGASNGGVNMGVASSMGGGASNGGVNMGVASSVANGGGASNAGGSLLGQEALMNFTRVVSLQEMLDAETSGYTDASSTGSVGSPFSIPQFLSGSGQSNPMENSPAMAGGPSGVNSGPSSNSGNIFTNGGAPISGISLGGGGQVSVPSSGALFNFGSGNGDPSNTGGGNPGGGQGAGYPGTGSPMSQSQNGGGPGGGGTGGPGGGGGGPASGGNGFPGTGSPFNQPQNGGGPAGGGGGGSGGGGGVMGSPFMSAMNAGQPSFSGSSGSPFGSSSSGSPFSGGGGAGNPFTQNMNSFDPFSSGNSLTGDSSNFGNSQSNQFMPQFNPNFGSSSSSGDGSGTFSMFDPGTGFDPFSTGSSDQSRGSSNFFGNFDPSSFSGFGGERSSDDGSSFFSPMFSWGKSGRAGGGAFSLALTRLVNDLSSVSYSGTGVANESSNTPENGTLNAIDVPSSLLNLSPLSSVVDDKFISDVVTNYCARYLITSKKRMNQEYYDDDDEGELAGLSRRGVVSEDDDDFAEVRSMTYNVWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K443</accession>
    <name>A0ABM0K443_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101853493 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108311.1">
        <property type="nucleotide sequence ID" value="XM_005108254.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853493"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="601"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="674"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="709"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005108311.1"/>
        </source>
    </evidence>
    <sequence length="810" mass="89288" checksum="582F1A160CF97E80" modified="2025-10-08" version="1">MLVPNEGRHIAFLERRGGGEQTRLLMARKGLLHFSGRTQYGYTDCETMLRRDRNPVFGIDSPVLCMELDDDYAYPSINQRKQVVAMELPGKYRNQSVHTSLVEKEPKGVAEQCSMSVKHEKKPVLQTVCENVPLRYTSVSPPSHDRPACPKSQSLCLTKSTGSLGLGSSEPNKSPVIYHSPSSDEIGQDDHRIPCSSANVPVVRIEDTDGSVDIRAKENTGDACVETGSSCVFIPGDDPCQNVLNSETLFSHFNKEQDCGRAKDSGCTKIHVELTRAKSCLAIAEEEENKKENKVCFASLDTLVTVCQDGSQGENNKNASYDPASKRRGARYWGKLRSMFKVVKPSSSMPNLSGGLSRSTGDMTSPFSQDSKTQTDSSSESLSENTDQNRIKKELSQTKTLLSSNKQDNIYKKKNKREDISTTPVDTILEEDKKTDDDGEEEEDDNFGEDAVYLDSRAVSKPLPIKVKEPTYSLVSSPSELDETTINFTRIPSFRGRLVHIKLERHFSTHSLNSADVEDSQNIKDATDIQPLNSGEAIVTDMLSNKMVLYNAEGSPKITFAVESGSEPWATCLTPDGAMAVTLKRQGCVALWATSGEPMIEFGQATLSAPTGIRCDSQGRYIVSDEKANGVFVFNKKGKYITKLSLGDISSIHSTKLPSSSFPPTAGPLKSFPHFNQPRYICITHSGNYVIADSANHCVRIFDSAGSYTGQFGGYGRRDGQMKFPYGVASDQAGNIYVADHYNNRVSLFTDKGVFIEHLLTSEKDGITRPKGLAVMNSLLYLTYGDLRSNKISVYSLSKIHERQIVNNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K467</accession>
    <name>A0ABM0K467_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Ras-related protein Rab-5C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101861540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108344.1">
        <property type="nucleotide sequence ID" value="XM_005108287.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108345.1">
        <property type="nucleotide sequence ID" value="XM_005108288.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861540"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005108344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005108345.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="22783" checksum="A19DB0424AE0C04C" modified="2025-10-08" version="1">MSSGRRNTGPRNGSVGGGRVQQTKLVLLGDQGVGKSSIALRFVRGQFPEHSEATVGAAFLTQTVQAQGQSIKFDIWDTAGQERYHSLAPMYYRGAQAAIVVYDINNANTFSRAVSWVKELRQQASSNIIIVLAGNKLDLATEHRAVQTDDARAFAEDNGLIFAEASAKTGLAINEMFMMIAHKIAGKPQGPQGRGQVVSLSDEGREGGGGCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K742</accession>
    <name>A0ABM0K742_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101864487</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110315.2">
        <property type="nucleotide sequence ID" value="XM_005110258.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864487"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045352168" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110315.2"/>
        </source>
    </evidence>
    <sequence length="1484" mass="164700" checksum="A37DEE6A5EF107F8" modified="2025-10-08" version="1">MSTMMAPFGFSVLAFAIYVCSSGRIDAANEHILKDLKPPAQIAKDFLANYKAKTALHTSELPARYKNILLESDDSASAFTGTGTGGNLGTGQHDTNAVESQQTNENINLNGCSSRMCHNLRYLRKYKELDEKIAEKFEVGGDQNVFSLVWHLYKFGQPKGGKNPWQNSLHLDVHLPVGTSMSSIRGAVLVLGSCGQALAVGLKAEGNTVVLLMFDADDAFRCEQRLREEKLTNVFVAVPGPGEFLESAVSLVLSQSAVNYNACLLNGLSELTEGLLPHEVEESMAKLLTVSRRLIVHFDVSNDRVEFFKAAWENPKGLLQKVCALSGVRLCSFNLSSGVGLDWNDSTFVVGGQECVNGSSKSLPCPGPDGSVPFNSLLNYNLTAESKLSLFSSLLGATVSIDDPALLMVKGGEIKRSSQSANRQSKFISEDFVQKPLRHDSRLKQSGIPLTSKSEAPHVDKGGQVSAGNDQPAYGQSLGKKEIAALVGKLIDQHKINSMEDQWNREEPASVDVSKTLLSRLQLVPEAGPAQPESRRSFDIIDGRPLEEQKSLTKAYSDLGERSVVKNVLKNPQEGEIYPKVSKKFVNGGTLSSNEPPRATGSAESSQDIRKLLKKRAKKNDNGRVEKIQPDIVIHNNEKPDAIINKDMKPVLMKPQLKKEADNSKAGMRKLLDFDPLHIAQPFDIAKQFKWKFSGESPAVGDGQDSVPLWKRSRNHFLSLDSTPQPTVLPSSTGSSNNTEKKYKEKLFQALWSMVRPLITRKLKRGADLAAFVSGQCYMSMLSTKLSLLNPSASVLALDADRRSKCHKKYSGLLESSGAKNNFLVRKVLDPDITFDMSHRPQVFDVQVIGPEVFSWLLHLGTEFPEFLGRILTLSRVTVIEVPSWDTGRKSLSLFPIDGLELMNDFKTLVDLSLSSVGAGAVSKVKELTNSQWKVLKETRVFAVHLESFSRNVYMSCVNSQSSLTRLDIWPSSITYRSGSETKSLSVRGLCLQILLSLDSEKSFRTRLFQSYLRVKLHPDMCPAQLHWRDGALRHLSDTDTDSESETLTMLIKKEIHEKRYSFMDYNSNNSSVGRSLAVGSPNSTFLLARPTHLQASHLSDVLNADGLTNCLSLRLPVTASYTNNIMKSPDIFRYQYFDFLQLLFATGSTAGSVAGYEDDVEFQVKVGEILASSVTSFITLPSPEILSLAATTFFPGTFLDNPELISDNVPAFQLADKVLLMQTPRADVDIKVHSSFLRHQKVPGSTGARFPWSVGVVRVMDLKLEVDHHFNFELDHHARKYTQFCHRDNVRSQPHVYLRRHEDDYKINYGNVNAISLIALLRMGLLPADKAKFYNSFVELPLYEDMAPWNIVYRGGHLEYIDQDTKDKTFDKLVPLAYQVMLVLVNYRRTVEDFRHCGDSASMLVDIPGIASCVRSQFGGPCNDSRYPVPCGDKSCRSTYIECLQVMQRKVKNKDTAKSVEQSSHVRKASSEVWGFGNNGMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7Z6</accession>
    <name>A0ABM0K7Z6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101864183</name>
        <name evidence="9" type="synonym">inx</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110953.1">
        <property type="nucleotide sequence ID" value="XM_005110896.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864183"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005110953.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47176" checksum="165B8B5CA62AB74F" modified="2025-10-08" version="1">MSLFRKSQSEDGVDRYTRLWSVLLLLTLALVTWLLPFSPTISSLATRPSEQPLNRLEPPTYHAKCWVPNEFTGSYADFANRICASFANSAYRGEKNVSLYRLTEDSGPINIPTMERFTPKLMTTSNLESRSHRQMTSQDSSLGPDTYLFLAVTVPLALFLFAVCLKLPLILFRLMSGFGSINVDRTLDTARGGLTLDTGSRRQLNFDLSRAATEAAKTSRGVALSYLMFKLLLCVVTLVELVVLGSLLMPQLTQLKDRNDNPGLVYGTSTQTSPDLHGKAYEFENDMLLICEFEIRQLQNVVTFDLQCLFSYDEGATAGHSRVGAETQQLAGDVLNGYHALLTAVLAYLVILLVVNVLSLITWTSKLVFGIFRSSLLQGSSSLSLDLSFLLLMSQENNGPLVTQELAGHLTSVTGLDRVMDKRTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8Z0</accession>
    <name>A0ABM0K8Z0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Zinc finger protein 532</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101845813</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111698.1">
        <property type="nucleotide sequence ID" value="XM_005111641.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005111700.1">
        <property type="nucleotide sequence ID" value="XM_005111643.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845813"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045914">
        <property type="entry name" value="Zn532-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47222:SF5">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER PROTEIN 532-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47222">
        <property type="entry name" value="ZINC FINGER PROTEIN 532-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1207"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1532"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1670"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1754"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1613"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1613"/>
            <end position="1623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005111700.1"/>
        </source>
    </evidence>
    <sequence length="1788" mass="195061" checksum="4FFC002D34DCD79E" modified="2025-10-08" version="1">MSALSSGSADNGEVQNLLVDPETTDLDACTDGEPELIKTGKDTSGSDSEPLVIDLQQNALFGDGELRQHEATEAHKTSSDLAEGDPVISRSEGDSYNSISVAGNIPDVHSVLSSQVSDLSKVQNSSKEKCDDHDGPLSVHVTAVGPVTAVAESLKELVSSDGNVDLSLSNNSSDTASKRESENSYSHEASVIPSQKDIELSIITKDRETYQSDASEKNSLVQVSSKPMETLPSKDGDLMVEDIEPGEDDEADEADDDVLHIDLTSRCEDNARPLEDNECTSSDIGYRNKILRPTTQCQVDESEQTMEKLSVDGSSLPKSFPAGSNVAGQSVSLSEAPADVSAVPSMRTVTVSLSPTTGTTRSSDTQQIPAGHGQLQHQEVNYSDNSDQLPSSTSPEVFGHFLSSGNPSVSDQTPGSLNQLREPVSPNSLVQGDSVSSLRSRVVDQVLGQTTSSHDTGVKDQTTSSHDTGVRGQVTSHDTGVKDQTTSSHDTGVKDQTVSAHDTGVKDQTTSSHDTGVKGQITSSHDTGVKGQITSSHDSGSSDNSVSSTISRFCLSTVPYISPVANSVPQTVDQPLVSSTDPEEFQPVIVSVRGNCDLGQVESSLSRVPAAEESTALNIGTGTSANAMVVVSNKVRLMAAQMKGNPHVFPEILPKTSDSNDGVLMPFSQQKSLTSLLTLAQKTVNDACVKGSQPVSSAMTLSGVPTPTPPTTSTLVQMIPVPSLSVTKTTSAQVSSTQKTSSTTFRNVLRPVQQSSGLTSVMKVSTDRSTSKKFPHTSNLLASAATTTSQFSCIFLQDPRSVQVKNLAVLIPQKSPSLTSSVLLNKSALPPVMASTATSVSVSSAPLIGATNTHSATSTSTESLVNETPRSLLNKVVTRTLNNFGVERADVLNSDILKVSPAPAEEGDSRNFVCSVCKDKFYSKVGLEYHLHRNIFLMEYFCIYCQKMLYFYNKCRFWMHINAESATPIQRVHNEITHLKVKPQNCYSASMIEDSDPVLMKMLSLEETEKVCRGCNENFPDLASLQDHLIQNPLQKALPCALCQMKLPTPCALKAHTKIHTLTLSSVLDFSCPECGVDDLKALCDNEKTCRPVFDHLDKCSHFNRVTTITCKCNAVFFDEISIKYHFLTKHMQTLYRCSYCAIAFLNDFPKLVSHCQSIHKIALYETQPVLFCSFCNVACKTYLEVGQHLSQHYKVWRATGPQYSRWKCFICQQCFVSKEELKKHADSDHTHKAKRCTLCFSLFSNRQNLVDHIVLKKCKRTLPVKLNLCVDLLDTLSDDIVATKMTELVSEIKSMLARKKNPFSATTPNSTTNNARTVTNTNVVLRKHQAAQPENRFQLRVAFSDTQGLSKAIAGGRKRKIAPKRVNQDSEVDVEPHQCHACKIVIRGAENFSSHLTRHALIGKHISLDVTRCVICKRLVTNAALSAHIQKHQEKGVKICSKCQRRDFKTMKEALDHGNTFCGYTFVNGIGEVVDPGCESTTVSQGEGQTSEGDDNNDIAMGDAVETDVAEGDGNNCESMEDPPPAQVVLFPCLLCGMTFVNKTDHDEHVSRMHDGTRIVYYCMACKKRGKMKMFKKRQVVVKHIAVKHRLTGAAAINKLIKQVEQNVTSGKELVASSSNSDKTTDAPPPKRLRIEAQGDFLCGKCAFSCSDSEEFSKHISSHNAKQEPQCPECGLCFTVASAMNKHLFAVHKIKEIDEYLKEKGLIESEEEEEEEMDTQPVQVYPLPCVSINDNESSAAKRKTRQVVEKNPLECNVCYKVFDSEATLKTHMRNHGMAFIRSRRHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9U6</accession>
    <name>A0ABM0K9U6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxisomal membrane protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101845742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112377.1">
        <property type="nucleotide sequence ID" value="XM_005112320.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845742"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005112377.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22446" checksum="2F7348A3BBEAD82B" modified="2025-10-08" version="1">MGTPDERKKQDSALSRALAEYVRLLQDRPVITKAITNGVVSGFGNLLSQVLAPDVSTGGRMNWRSVFAYSSFGFLVNGPLIHHFYVYLEKIMPKNRPNAGIKRVLFDRFIFAPPFLLLFLYYVSIVEGAGQEGAVKKIKEQYWMILKLNWTVWSVVQYININFVPLKFRTLFGNLCALVWMVFISVKRRQMALKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBC0</accession>
    <name>A0ABM0KBC0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DCC-interacting protein 13-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113492.2">
        <property type="nucleotide sequence ID" value="XM_005113435.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856782"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047181">
        <property type="entry name" value="DP13A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415">
        <property type="entry name" value="ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415:SF2">
        <property type="entry name" value="BETA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113492.2"/>
        </source>
    </evidence>
    <sequence length="303" mass="34806" checksum="F2FEDC88D9196829" modified="2025-10-08" version="1">MTAQNELCAATQSLAQHLRSYEVQKFPLESEDSVLTSTLKQFSTYLDDISSVQQVLAQQFSETMMYPLNKFLQADIEEISTMNQMFQSATNDHEQSLAKYMKQPMKKDDKSRVEVNEELQGNRKKFHQTTLHYYSALNALQYKRKCFLLEPVMGYLHAQRACFQMGQDIVLRSDLEDFLGDIGSSVQSVHSDLAKETQRTVELIDSIEKQSQHMYHAEPPVDMPFIPPNTNLTQKAGYLFCRGKQVLLSTKWDRMYFFTQGGNLMSQTKEEFAGSLVMDLNEEGVVVESCVADDRRHTFQLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUQ9</accession>
    <name>A0ABM0ZUQ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011070</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934855.1">
        <property type="nucleotide sequence ID" value="XM_013079401.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011070"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF67">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012934855.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44689" checksum="5EBCE7E90BC7B0B0" modified="2025-10-08" version="1">MGCRPISSRLITIRLRAVPFNITIIQAYAPTSNYDEQAVKGFYDQIQEVIDQTPKKDIIVVQGDWNAKVGKDAYKNWKGTCGQYCNSESNERGLRLQEFASYNNLVLTNTLGQHKASRRWTWHSPSGEHHDQIDYIMVKKRFQSSVKIGKTRTFPGADVGSDHDLVMMTFRLHLKRVKKQGNTRMKFDLEKLKDPDVAEAFQAMIGGKCAPLTVIDAGNNNDTDMDTWINTFNTAMTETASPILGKHRRVNKPWVTTDILNLCDKWRKLKEKKKQPGGAKEYRANYCTISLISHPIKVMLKIMLNRLKPQAEKIIAEEQAGFRAGRSTTEQIFNLRILCERVSGGNANGDDGSTSLNSLVSQRFKSTIVTSGAYHLWFFHCDWEINATYNNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUR4</accession>
    <name>A0ABM0ZUR4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase DDB_G0268948</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106011073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934863.1">
        <property type="nucleotide sequence ID" value="XM_013079409.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011073"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="52"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012934863.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34618" checksum="D8F5DD4A0C32848D" modified="2025-10-08" version="1">METVTPDNSQFYSFKDTSDLYIKYRPTYPERLYEKVIKFCQESETCTWELAVDVACGSGQSTLPLAKLFKQVIAVDSSEKQISQAPRHMCNISFRCGSAYNLKFISSGSVDLVTVATAFHWLDPERFFEEADRILKPGGSLILYSFGTDSFTHHEADRYIQYLNISSKYVAKYHPATEKLINRYRDVTLPYPGWRRRLSANGTLGVCGLSGFDPDGDCGLMSANGGAGNGCSDEMTPQSLRNRSVCVAVNFGAAIRRQLFTDAKWDKGPPEAGDQSFGSFLRPLHYCNDEARTAEEKVSRLIEGIEYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVV8</accession>
    <name>A0ABM0ZVV8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protocadherin Fat 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935617.2">
        <property type="nucleotide sequence ID" value="XM_013080163.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845992"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012935617.2"/>
        </source>
    </evidence>
    <sequence length="306" mass="33027" checksum="83115EED09A52B92" modified="2025-10-08" version="1">MQDIEHSVSEALSVNSVLMTVTADDLDANLDINITYSLVSLNDQFAIDAVTGDLTLIKELDYDAMGSDKTLKVIVYAEDGGPGMKLTATATLTLTVQDSDDNGPAFVYEGCFKHNDVCAWPKYTTGLTLKKDVPIAVFPVPNKVKSHVEIEAFDRDLGMGSEIEFSIASTIPPGNEHKFRVETNRLAVGNKYRASVIPLSDFTVHEGFEIFLKAEEKTVEKKQEISMIFFMGDAGGSPGAQGQGSGNGNGDDDSYSDSEIALIVIVAILATLVLCMGIALLFCWRRSCHSKGTDIQMGMTNNGFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW12</accession>
    <name>A0ABM0ZW12_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935703.1">
        <property type="nucleotide sequence ID" value="XM_013080249.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860008"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22104">
        <property type="entry name" value="F-box_FBXO33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF3">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935703.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="51628" checksum="639A44AC475393A2" modified="2025-10-08" version="1">MAAGGDWASLPSVVLEEIFSMLLPKDRINASSSCRRWREYLFLPQFWTVISFNLNYRGRLRTKFLSSKCAKFAKEATVEFNSTRGSQVWDCSRLLELLSRNRHLECISLRPSNCYFDGGSESLQSFLESLQLLIKRNKRLLHLSLGCTEILLHNSQELFNLLVKYHAPYLQSLHLATVKEDTSSYDVPYIGIDNFAAFANLRALSIDYDFVTPKFLAVLAHRDRGAPPLHSLCLHIHRVNQRQPTDSMWKEVLSANLNMELTLNLVHSVDGLQALLDVLKPSMPLTHYRQYFCGDVNVASLNMMSSLYYSTLSSLTIVEAINHQPINYTVNDTEDPFVMLAWRCTRLQSLKLIGMSLDQKDLVAIARLRSGLQQLTVPSCCVFWNEEDEDYYDEDDALVDLEYKISESLGRPWQPLSEFLIPPAVFYHDADADSAYMPELLKDQEWQRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWN2</accession>
    <name>A0ABM0ZWN2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106011343</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106011343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936043.1">
        <property type="nucleotide sequence ID" value="XM_013080589.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011343"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047197000" evidence="2">
        <location>
            <begin position="27"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012936043.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27489" checksum="CA77FABDD7758208" modified="2025-10-08" version="1">MFILALDMRLILLLLYVTSFASFSAAMLDVNHSELRYVADHLTAQKCSLLLKALKQKQFQLQEQNPAIEFEPKPCMTRLTRWAEHEGRNMTFDFLALRLREIGMKRLSSRLSKRVLHKTSEELHRYFLDDPFREMLPTKSVMIPVATSAQLMPAPDEEDTHDHLFAVVVVMATICLTLFASACACILCPRASHFLCLRACPSVCSASCQVLTEGCQRAWHGTVSGAGRYMLVVPRGAENEGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX47</accession>
    <name>A0ABM0ZX47_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuropeptide SIFamide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101846805</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936328.1">
        <property type="nucleotide sequence ID" value="XM_013080874.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846805"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012936328.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36066" checksum="BD254049FFE01D7A" modified="2025-10-08" version="1">MQSGWQFGAFMCKALPYLQAVAVCASVNTLVVIAVDRYLAICHVMRQRNTKNMARVVLVVIWLVAFALMTPWALYFKMEMYVSQVQKIDMCVEVFPEVWQKKAFFLGVIFLMCYALPLAFIIACYFMIGYRVWHRDAPGITSSMGVIEKSKVRVVKMLVVVVVLFTVSWMPLYIIRLIILFADISESSPQSAIIHNIVFPFAQWLGTSNCCMNPLVYCLFSQKIRRRIRAMLCCSKPELRSLYSNRSMYSNALQHSTNTRDSTVRQEHTGSGYSNGHAGYGHHYGGGNLYHHRSARSDTEFIRLHRNSNVRSTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYW7</accession>
    <name>A0ABM0ZYW7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine-rich adhesin for platelets</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101849922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937396.1">
        <property type="nucleotide sequence ID" value="XM_013081942.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849922"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046416442" evidence="3">
        <location>
            <begin position="29"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="42"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="216"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="414"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="861"/>
            <end position="891"/>
        </location>
    </feature>
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        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="913"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="1064"/>
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    </feature>
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        <location>
            <begin position="1072"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1144"/>
        </location>
    </feature>
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        <location>
            <begin position="1145"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012937396.1"/>
        </source>
    </evidence>
    <sequence length="1310" mass="136942" checksum="59351E4C3BE70632" modified="2025-10-08" version="1">MTFSSGHIMSLCLLAGLCLLVSLSSLEAAQDSLCTTDFKGTPSCNFDSSCCTFKSVSSSPNGSRWVRSTDGPISHDWQRPGKTKIGSYVYLNASSDNSSAILIGQLDSSIQSVCVELHFATSQPSSFDVRVYNTMSPNDVTESTLLYEFQNLSSVGQWKTLNVPPRCVLQHSYIAFESSGASQDGTVALDYIKITRSSLNCPNSDSQCSNVTRGTPSCNFDRTMCSWSQLSVTGNGPKWTSGGGAMSVQGPISHDWQPAGSNKRGSYVFTDLSNVTTPVTSTLLLASQLGADISAVCIEFHYASTGQLQHRLRVYDSQSTSEVTKATLLYEINDISTGGRWMTAQIFSRCVQKNSFVVFEVTNVTQESSVALDYIKITRSSKACSTFIPTSTAASPTSPTPTFGRCSNNTRGTPSCSFDHNLCSWTTSLTAAGAGPKWARGGGADQVKGPIPHDWQPEELNKTGSYVFADVPQNTSSRRFTSLLTSQLAADIRAVCVDFHYATSGTLNHTIGVYVSKSPSDVTGATRLYEVKDVNTGGHWISAHISSQRVDENSYLSFQVSGVSHESTVALDYIAVTRSTSTRGRSSSPSPNPPTEVTSPQQATTSPKSAETDVTSRKLFSSTPLFTSTSTSSEFSHSTWFSQDTTTPENPALSSGSAVTPVSTYKTSSTIPDTTVPRKSQSPLTRIPTSPNPSPRAHSTTVSPTRDFSGLSTEILQSSSSSSSKPTPFASRVTPTSAPHSPSTQHATRALTSSESGVPSSTVSSESSVPNSTVSTGGSIPSSTVSSESSVPSSTTSITETRSEPSLRTTIIPATTPASTEPVPAFLSTTTTTFSPNSGTSPSVSSPDSSVTFTTNFDTLPSPVTSPSTATTSQKSGTSSSTVNSSTQKSGTSPSTVNSSTQKSGTSPSTVNSSTQKSGTSSSTASPTQKTGASSSTATSQKTGTSPPTVTSTQKSGTSSTVTSTQKFETSSSTATSPSAATSTSTSKSDTSLPVTISQSTTTFTSRSSTSPSVSSSYSTVTSSPRPETSSSSQTTSRKTPSSTKHPSSTPSTGSATETSSTDVTTEEHRNSTPSSETSSHKNPVTTSVQLTSSTQSNTPLTTETSSATSSKATKATGIASSPNTSPVSQTSPTTSPTETSGSTHAATSPSFHPSTQTPSSRASLTSVTPSYVTSTPDIHHFSSSNTQNTRSTSRTSEKRWLTTPATQSESPQTSVSTPGTIKYSSPIAEQNSEDPLKPGAKAAIIVCASLVCVALIAVAGVVAYKNGKRRKQLVGLYISDAELISRTDDLGEDNTRPVNGVLSIKNTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZE7</accession>
    <name>A0ABM0ZZE7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sarcoplasmic calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937683.1">
        <property type="nucleotide sequence ID" value="XM_013082229.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851496"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012937683.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25311" checksum="11ECD97F7644369A" modified="2025-10-08" version="1">MDEQRSLEENTAFSSFVEGKIKWWFDLIDVDNDGYISKDDFLIIAIRFVKEHGMEEEKAVMLKRQLVKAWERALLKPQLFSEDDQNPEMREDVPLIIKVGEELEAGHHIPKDDFSRAFGQLINYNSLLARNILETLVNVFFDMFDKDDDGFISPQELEVFMRCLGTDQAEMAQLALSCLDTDRDGKLSREEYVGGWCEFLLSQQLDHQFITAFAPHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0E4</accession>
    <name>A0ABM1A0E4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Latent-transforming growth factor beta-binding protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938275.1">
        <property type="nucleotide sequence ID" value="XM_013082821.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861044"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.20.10">
        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051586">
        <property type="entry name" value="PKC-binding_NELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042:SF5">
        <property type="entry name" value="EGF-LIKE CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042">
        <property type="entry name" value="NEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="558"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012938275.1"/>
        </source>
    </evidence>
    <sequence length="720" mass="79103" checksum="E964E677380EC5F1" modified="2025-10-08" version="1">MEMCVQDQCDGELRFCEYLTSQPFECDDMGALLSIINDKNCGEYCGENMQFTYSVISKQPTCSEPDLVPVGGEDEFDDYEFGCVCKQGFVMSGNYMCVREDECGCTMEDGEYRQRDSVWRSEDCSKIYTCTGPGENGIVEEDSPCGENTECLDTEEGPACMCEEGFFGNPIMPEGCEEGKKDDDGSKICYTYVNLDGSTEQKCNCTMGYVSSCNDCEDIDECKLGLHECDLSKENCVNIPGGYDCECADGFKETDNGCVDIDECKEQRPCGDNTGCTNKPGSYKCECCAGYKMDDGECVRDTEGFPDIPDDAQCCLQCNIPAICKDVESEPVPICYTKPDGEKQTFEDGKVLFQTLCLNGEEFVPSNAQKGQKCPEEVEPTEPPTPPPTTEAPAATTAGQAPPSSCDVDVLKSTLPPPPPQLSSGPVCGPSNGPDPQTYDSYYEMAQAVCQSSGSPRNMPTLSPIAAEPGPCEEEPEVTEPVVTIPVIPIPAPPLDPEFNPWRPFGDCKFRDAEKGCGPGVKVRTRSVKERTDGQETRDPFPYEIRQEASCFEKCDDPEPQDQCPEEDFCEGNTYDPVCGSIDNGMLETFDNLCELERIACVADKPFNVQYNGKCKEDDEEPAKRMCADGPVPGTVHYHHSSLVETCTGPSVEIFTCGELLCEGGSDTCCKPIAVERKEVDIMCYNTSPEQEFSRTFKHIHYSAQKCQCQENTQDDFGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0P2</accession>
    <name>A0ABM1A0P2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101863985</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938442.1">
        <property type="nucleotide sequence ID" value="XM_013082988.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863985"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037688">
        <property type="entry name" value="ZBBX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28634">
        <property type="entry name" value="ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28634:SF1">
        <property type="entry name" value="ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1230"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="968"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1277"/>
            <end position="1294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938442.1"/>
        </source>
    </evidence>
    <sequence length="1294" mass="141845" checksum="1D96DF89EF6788DB" modified="2025-10-08" version="1">MSGFNVSARKEDMSMRLRAQNLRNARDQTKRLEDDNRKMEDRLRELKTAMTREKEERERQGGGFWGRGQTNTGSLTNYATEVLHNKAEKPPKEGKKKKVKVLQDQPIEVPKRSSQPGTMKYIAQRKLTSGSTPRDKLKGPRCGQCEDRTATLSCMQCSEIYCPGCFAAFHLKGALKQHRSVPISASGPRVCMSPSPSSAAPSPRGGQASGAIVSHTMSSDNGSEASGPSPSHSSPRDSVNSLLQGNYDESQSAASFQAALMAWRQGEEPSDSSPEQRSPRKPIASPIKSPVVAVDESTGTVEESKALEIKFTHTLSYAERLMLKKHRRTELAEMHTPRLEGQGQAGMPELSLRSDRHERKLSGRASGRPGSSGLFATGRSVNAGRSEKDMTVSRQDTMIDDEERVDFHALFDAVVASESPDQKARTISSQSCVSVTEMPSDTVTTSDVPRLKPSATYVVEEVSPFESWRTQHKNKMGPASSSTFVIDGPQKSRSDDASQRKKINTITELYTVDDDVVDGSATPSRPTHSPVSGSDGRHSNFSHPEPDSDFSIGSRHVQNKSQAEQRKDPSLGQETVDVFGENEKPLKTPRAKSAKSRPTSSLSRANKSRPGSRAQSRAGSRMEVEGLLTKTPSEALKRIVQMEPAAEYSYRSPMEDFFLVGVEGEQPKPVENRVLTPSNARKPTSRPVSRAGAKSATLEKATVKVSYKLYQMAPRSWRPDSSLGETVPVDQVRLDAPEDEEITLSYSYSRQLDGHAVDVRTDSSLSRVDMPSDDLGLNAVGVFGDELFTDLAAGTPTPRAVSALRSRLSMDRGDSATPVARDSPVPSSRLSARQKSLARRSKDTATPTNQSVFPEERVPTPPSSSHGARIGSATPVRDRLRRKSDMRRNNESTDEGRDSVTPTPVATREGHRILPSRPGSQHFRKEKFGNLTDSASHREHSQIQADSGSSRHSPRGAKSNVGRELSGLSRQGTADSFKSSQQRPVSRHTSDVSVTRRPISSTHFPSSAQARTSQQQSQDQRPNSSTGGADQLRRTQPTALSYSRDDHPDTVVADLMMSRVREDNWMSGSDDGSELDNKLQDSSSYADNDIKAQPSSSSSLQRKLQSPAISGTKERQHWKVDSSHWETEVRPFSGVSMDSRTGGSPSPSRVNSAREVKGHDRSMSSLSRASGRESRAVVMEGEDLSCYDDMGVKDEQNMEDKQALDQLEWELASDTGRLTADGQVSRMSVLDNDDDVVSSSSSRSSTRSLQMGMDKELDISAKIQEDEKLAQADVDDKEAVHDQMVDEDDVRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1H1</accession>
    <name>A0ABM1A1H1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Corticotropin-releasing factor receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101855025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012938918.2">
        <property type="nucleotide sequence ID" value="XM_013083464.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855025"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF15">
        <property type="entry name" value="DIURETIC HORMONE 44 RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="85"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012938918.2"/>
        </source>
    </evidence>
    <sequence length="420" mass="47888" checksum="FE0065371AD79DD2" modified="2025-10-08" version="1">MKNNNASRDLSMDVLPELFDPVKAMEEMRVFCTAYFAENPPYKANVSKACLENGTWGPANYNACMVSEPMNNILDYLDPKDLMGVRIIYNIGYTSTTITLFIALFILLYFRSLRCLRNIIHCHFIVAFIFKNIFWLVLHNGLARVLISGPPKWVCKVFVFGYNYFHTTTFFWMFVEGLYLFTIIVWAFSTQKIRIWHYVIIGWIIPMVCVLAWAVVKANLEDLVCWLPLPYVERVPAYDFVLYAPTIVVLVCNVMFIMVIVYVLVTKLRASNSMEIRQSRKAVRAAVVLLPLLGITFVFFLSPHQEEGVIGIVFKYINAILSSFQGMFVAIFYCFLNGEVRLLLRKKINALQESRTFTRYTKSSLFGSPRRSSCYAMTVTTTNGKAGGVKRASDGSARSKGSRAGEQETEASASMMENML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3C0</accession>
    <name>A0ABM1A3C0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012233</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939981.1">
        <property type="nucleotide sequence ID" value="XM_013084527.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012233"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012939981.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23372" checksum="C29044AEDE158EDA" modified="2025-10-08" version="1">MKDPHRAAQVLASDSLDTYAKKFEEAMSGQGVSRKECLTHDTKKALVQTMRGLSAVTKHLLSSGFQYVLLREIQSDRIEGEFSVYRQSTGANAFMTAGDVISACKKRLARHPVSFLESIDVIADDSPSTSDKHLCCGPLVAADGEAIESSFSDVTLTANEESCCAYVAGWLERKCIDDITFSDDEPFVSTEVKNFLEEVSRGSLKTPICLRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4V7</accession>
    <name>A0ABM1A4V7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adipocyte plasma membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101856199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940879.2">
        <property type="nucleotide sequence ID" value="XM_013085425.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856199"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012940879.2"/>
        </source>
    </evidence>
    <sequence length="226" mass="24704" checksum="6E10CC9C4AC0618F" modified="2025-10-08" version="1">MKLPPPPALSGTLATNNVLYEAERVHDGQIAAPHSYVPLGDSLFAVTKTGLVINVAPCRPVLLADLKPRGCRSPKECGHPVSMRLNADKHLIVVDAYRGLFDVDPVTGFDPGNRQVKEILVGLAYPSGLELTTDGQALLVSERRTMQQLKMMYHKRGMAVELDDRGRVRSSVHDPTGLKVSEVMEVKETDGMVYIGSRDQDAIIRFPLPKSYGTDLSVTSTLQEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5D6</accession>
    <name>A0ABM1A5D6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transgelin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941147.1">
        <property type="nucleotide sequence ID" value="XM_013085693.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012525"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941147.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15651" checksum="F507C99D6DCEBAE5" modified="2025-10-08" version="1">MASLRASKSGSARDQQAKVESSFDPEEATKCLAWIREVTGEPIPVESVVDNKHKVSEFFYRTLKDGLLLCNLINRVVPEDMQISFRSQTFKKSNNEAFESARERARIELFVYKCQEFGVPEALPFQPDSLYEKTNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A667</accession>
    <name>A0ABM1A667_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101858430</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941585.1">
        <property type="nucleotide sequence ID" value="XM_013086131.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858430"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941585.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23503" checksum="220D25F18AA09003" modified="2025-10-08" version="1">MMDPDGEGWDSDAFDAIDSVARANDVADDIAGSAFLPEVRSSPCPIYSRNQQQLGVSLHQQLQHQRSDARNDLLYSTNCHGGQTTHRTHSRGSPRSASSHVNMESAVQMERDLTFQRDVQAGKAQKYARPILPKEMTSHDFVKSWLQHGSEPKPQVASHFPDIITKKEANAVTAEKKPPRKNAAKKPTVQSTSPQQHVSKRRRSKDPQVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6X1</accession>
    <name>A0ABM1A6X1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alanine--tRNA ligase, cytoplasmic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942014.1">
        <property type="nucleotide sequence ID" value="XM_013086560.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850429"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942014.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="47385" checksum="2E53853B431A9768" modified="2025-10-08" version="1">MRNHTATHLLNTALTSVSPSSQQQGSNVTPYKFSFDFLSLGAFGSEQVSQVEESVREMIQKSCSVSRHIMSLQEATSLPNVTMLQNEEYPEQVSLIRIQSPDGSEVLSSELCGGTHVTDTVDLQEFCILQSGTKAQNVKRITAVTGSPARQAHLTGQGLASLCQLLQLLVDNDEQAAGQLTETSMKIQEVLVSVSKWRQELESLLQLDHSDRSGARDMWTQTLDDLEKTEKVLSSLYPQLIPAQITSPDKPLLMKEIVSTINKCRQLDLVPKTQRDRAAECTHSLTHKVTEVVNTRNSRILQRLIDQRLSQSDSVHEQVVCVEHELDLSARQMVKLLSQRSDNMPILCVGQEVSGRSRTVVLCLPLSHWQPLGKEEISKIVPQKGSQKSSVGKAAKTTKRAEVYTFSVSADTPTHVLSGMLHAVLKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A703</accession>
    <name>A0ABM1A703_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101854064</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942079.2">
        <property type="nucleotide sequence ID" value="XM_013086625.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854064"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046297565" evidence="4">
        <location>
            <begin position="24"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="158"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="772"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012942079.2"/>
        </source>
    </evidence>
    <sequence length="920" mass="104733" checksum="611683A5F77E8BFE" modified="2025-10-08" version="1">MMSVPYLALCMACLASVFWDARCQDAYSGNFSIENCNWGRQHVLDFAGKKVNVSIAGFAGHNLSANVTCTTNIYARNDYIHLKVSRFSLLGCSKCTPSSERLTISHAGFRTSDSITWCGETYAEELYFKGTVILEYNTGLHGEGDGFDIEVSRVTRPCVEEQTLTVTDKPRLLYSPLYPNKYPNLLNCRYKLLGLGQNLRIRSLSFDVEWKDRCLYDYLRINQVRYCGIQSIDVLETSNFNSARVHFHTDRNIGLTGYVLEYFHEHQYPVVCDGNTSLKLIELPSNESSLLIEVKINRTTKSNCTLEIDAGSDDKVLEIRTPSRQNSIDCNNVFIHTYNHSSWQFTGCPRPVSYLRTSRRTFRFMVTTTGIRREGSTGDYDVFSLHVTPLGKDILPPLLSAENTTSFVWIDKEMMRNSSQYVTHITKPSGWKCIKVQTLRFDMGQLQEYGSGSSRQSPNLMPVSDWLTVHNGRNSSYFDLTMGCGSSKSTDSQIYSKGTDVVTVSVNMRMEPKTGFWFSFQATDECTWPVIQLNGNRGKLHPRYNWKLKNLFCTWEIRKSSNSYYSTEAVKIKANNNFSMISSNRFRVFEVGRNDIKKIADVNQGSSRNMWVHVEGSARVEVEIVSAPANIPPPNIFDFEYVLFYSSPKQCGPYELKALTSPQLAYTPNYPNFYLRKTKCTWIITKDPSAKGSLLLIKFPVIICHTLTNQKVYTSSVSGSNHNWHLESTACFNGYSNKKPKSQEYRAEALKIEFESDYPYPSFNFTYGIGGCVNTLINLTDYGMSYTLHNVLPPWTQIRRDCLFRVITEPSHVIRVSFDKLSLNQDNTHYCGDNFFTVTDKCDNGNSLGKSCGAIKEKTSVTSLGNVIVIRLHTEISTSMDIVYNFTLTAVPRDPCTQRRFVYARDRRQKMDYYPSDSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A710</accession>
    <name>A0ABM1A710_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012759</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942091.2">
        <property type="nucleotide sequence ID" value="XM_013086637.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012942091.2"/>
        </source>
    </evidence>
    <sequence length="380" mass="43536" checksum="A4A20B1101B7CCA8" modified="2025-10-08" version="1">MQQQQGEDDDHGLSNLGTRQILNWSPSDISMEALSRALGEKLLVAKKNISKEVRFKPTCQTPEQIAGSNCSKDGCLRTELPENFRDRVKQLVGNPKFQLSPQYKEAMAEMASQIEGRYEIILLTAASSNHFFESQALMKNLHTYVFPRLRNFTLIFYDIGLSEEEHLQMKKYCQCQVVKFPFHLFPEFVRNLKCYSWKPLMIKAHIPQSKLVVWMDASVRFRPDPQLLPRLLQQAQDRGVQMGGSGADSPYRTDVAMYHFFGDEPCAYLGLSQAKATFGVFHREPFVDKAVLEPWCACAVKKNCICPSDRHGCAESKAAVLSFRNRSGPLRLGLCHRYDQSAISTILHKLYQGYFRFVLIDILKFIQILRKTTENYFPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A772</accession>
    <name>A0ABM1A772_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012783</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942182.1">
        <property type="nucleotide sequence ID" value="XM_013086728.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012783"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942182.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12122" checksum="B42C797A28193462" modified="2025-10-08" version="1">MYIGMGVYMFEKKDLLMKEIQNTEQELQSVEQRVEKTKNEIKHLNNRLEKLDRELVSGRSQFGVERTLAVCCCAMDRDEEEANGYLGKVREELETVHLALKNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8F8</accession>
    <name>A0ABM1A8F8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ficolin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942826.1">
        <property type="nucleotide sequence ID" value="XM_013087372.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012949"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942826.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20852" checksum="CFA88BE64D303BFB" modified="2025-10-08" version="1">CDTETDGGGWLVIQRRASAAVDFFRGWDDYKNGFGDLDGNFWFGLEKVHQLTNQGQYELRFDFEYEGTNYYATYSSFSLDGEPDNYKIRMSGFSGNLRDRINYHNGQPFTTKDRDNDERSGDNCAVERHGAWWYYSWSTVNLNGEWASTRYAKGLFWADVTGYGESVSFSEMKIRERAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8H8</accession>
    <name>A0ABM1A8H8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chymotrypsinogen A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101845422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942859.1">
        <property type="nucleotide sequence ID" value="XM_013087405.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845422"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045664793" evidence="3">
        <location>
            <begin position="27"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="97"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012942859.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="39982" checksum="990AFF57B26792E6" modified="2025-10-08" version="1">MSWSEHSSGLLGTLSLLLITIGCVRAQHQSQCSRFNQGGFCIPVKDACPSGYEEKSHFSNYIGCSFQLGKKCCAVNTLGVQSRQVCGKGSLNLSPKILNGDLTGDCDWPFIVSIRALNAGSASLTYDTSSHACAGVLIDTQWVLTSPFCVLSAGQSISEAPNRILVVAGEYNVSGIDIDPLTGAQQEQLINIDAAYFHPDYPYRSQASLVRVLQTAKAVNSNGTALLHLSRPITGSCSGIVCLPTEEEAANDCASYDQCVMLGWGFNKADFTGIDDNLLLGNIQLTSKTACDVLTTKLGLTGIRPAGSICQSPRSTNTDSCQGDEGGPILCSNGVNWVVRGVIPFNLCNNGRFNFYVTEVASSLDWIKRITRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8Z4</accession>
    <name>A0ABM1A8Z4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable serine/threonine-protein kinase CCRP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943106.1">
        <property type="nucleotide sequence ID" value="XM_013087652.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846765"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012943106.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="54005" checksum="B7683093BCDA1D43" modified="2025-10-08" version="1">MSATFRLGRPLFETHTVNVSEALGFKEDRLLAGGATAQVFLATDVNHPEKKKALKKFIFLENGDPVDKPRKWFYFVNEVAMLQDLLHPNIIAMERAASCPESLVIVLEFHPVDLFDALPRVSDEEATRYFTQVTEALSYLHSRRVVHGDVKLENVLVSKDGVAKLCDFGHAQVVPENTDSLKEWGSCAAYHGPEFKRGHPVKDAFKLESFCVGVLLWALVFRKKPQKNTDYLKLLDSDKSVSPAYRQYVQRLLCADPTERSSVCQILQILNTNGHPELRVRQNVSAQALVTAPITYNSTGEEVACLYFGNSPIEQRPSSSFCHPFNEFSYQHAGYDQQFVHPSHSGNLQYFPRETPTQYYYMNQSSGLATFHTASTCFDSSAYQTETTALYPQYEDVSSSHYHQSPLDLQRAQWPVVTDTNQRTVQQPAPSSLGHSQFLTHHQNCYQPDSTACFQYVVPSSFPEYFHPATFQQYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9B8</accession>
    <name>A0ABM1A9B8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein O-mannosyl-transferase TMTC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943293.1">
        <property type="nucleotide sequence ID" value="XM_013087839.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013076"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052384">
        <property type="entry name" value="TMTC_O-mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943293.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26456" checksum="31459153254AEED5" modified="2025-10-08" version="1">MKNAAVSLRRLKRYPEAEQLLKQALSVHGDSSDYYNQLGLLYAEMGQTLDSLFAFRRSLALAPNNTLTHLRYLKALSEARQHEEVSRGLRDLLQRASNDVDVLRFAFVHAQQRDDLDGALHYAQEAVAQAEFLRHPDLAAFYHDLANIYRQKQDMEKAMEIFLLSVEQDPSYSQAYINIGALHHLQQNFEEAERYYLKALSLEPDNELCAANLQKLRKVWKKSSDSLAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9C9</accession>
    <name>A0ABM1A9C9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tectonin beta-propeller repeat-containing protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TECPR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943321.2">
        <property type="nucleotide sequence ID" value="XM_013087867.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857598"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF1">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06462">
        <property type="entry name" value="Hyd_WA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19193">
        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="4">
        <location>
            <begin position="82"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="5">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="4">
        <location>
            <begin position="1697"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="5">
        <location>
            <begin position="1769"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1314"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2021"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="890"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="969"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1314"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1344"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1367"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2033"/>
            <end position="2043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012943321.2"/>
        </source>
    </evidence>
    <sequence length="2043" mass="222588" checksum="F071B6E5956C8BD2" modified="2025-10-08" version="1">MITKFIGYQNSRMNRMPVSKLWLLNHDGTAFTLGSSQRRFAQLDNTWDDSVPVKRVSASHWCAWSIGHDHRVYIYVLASDVPIRVPETTYENQRWTPFHGFSGKGLIPTDRPGWSCERGHEYRPKENVRLPSAHWAWEGEWFIDDNLRGEVVGYEGWQYSFDFPGVYTPEKHWNSCVRKRKWIRFRRFSSMEVWARISDMEVVENTECFMDLSVGGFLLPSQPAGFLSVWAITNNGNVYVRTSVNHENPEGSLWQMLEIGDHMGLINVSVGSSNLVWGVTWDGHALVRNNVTKDNVYGTGWTVVEYPDEDTRLMQVSVGKHAVWAISRDGQVWFRNGTFGDDMFWSRQSAVGTSWVKMVGEMSQLSVSSNDQVFAICNNLKEVYFRTGVTRSNLTGKTWQKVELHEDLSVLARHGLLSEGSVCFCGDKNAVCELHERRPRFSSVTTSCSSISSATVAEEDSSEASGSYSPQHFTGGIHHAVIPPAWDAMRVPSMMEELPQEGSNNDDDVNEGWQLEKGGADDDQMQDGDVFAPAAVAAIESSVAESFASETSVSDTLMASTDTLTGTSVPSTITAVGDTSDVYGVVSPSASQASTISLGRSVHSDEARETFSSPPHKAAELSSTSPSASGVGDDGVISSQGGESVSYSPESEKSASSDSNKAGKEHSSLAWTSLSGNGVTDAALQSDDSVQGGVTVQGNSASHSGGLVAANKDVHDLQERSANEVSETHAPEHLSEPATKSSLPVGDLHSHQSSHSDHSVSVTAETHGAHMDPSGDPIESAVSRKTVTNGGDGQVPSHEGSVGLLSQLSENETKKSTESGVAGTKDGQRLVEENSRVSKLSSEETPLSGEEGASKSSPPACKVREPGEISPEKSDRSPKSVISKLLGQMHSKSSGNAGLKTLQTGSEKGASYSSVSQHSKDSEDSIPSASQSVVGDKEHDSVAHSPKLRRSKEKRVKISDENSIVFKCQNKKKSKKKKALHDSVTEYERGGTDSDVDKSVDATSLGSNDTSSIDDSSRYDEPTSPVPESNFPATSSDKGPGHSIETPLVTADQRELEESHVMTQSLSDDRVDSAPLSLNDHTAASVICEPTRVVADMSLVAPTAEKSVEVTRNIRGEGTPDVGEMSMASSHDAKAFSASVDVQKAPVSLEPNPESQKSISFSEEKSIHFVVQRQEESQDENFSSLPPVIVGNNTELSESNVEMTIDKAFHSLEVYMNEHNHKQEADGHSPSSEGGEGDGQGSRPPLTKQGSFENEQSRRSAEFAGSRLGSLNSSMASDEIIDFVTDLISDEEFSAEAEEKTGNSLENENCAATDTQGATQNGSGSSERGNTSASSDAGTMRQMSTASSAFSGSGSTDRGSVIDVFSPTETLSSQPLPSDDSTIPAVEPQPARKISRYRKSPTPSYEPSGPVIPLAAMTEAQPRLCWRWLDATSCVIDDPLNVPWLTTSRLETGNQVAARKKISRHLRDGILRQIVKRNEREAYTFKNIEQAINKTTWVKKAAMHMFRYDRKSSWVVCSVELEQGIGNLTEGCLTVHYQLKGKQKHTQLSLSEMTCVKTSSDPDLQSAFTVYTSMTNLIHQPLMLRANSEMEAAEWIGYLSTANASAWNLNQPIAAGAVWSCTFTGDIFVSPARSEEQKPFDLCWGQHGGHMSVVETGPSGVTWGLGFDRMAYYYNKGYGGAISSGQGALSDNTVPVTDSHRVFVYENQKWFPVVGWCNKGVFSNNFHWVTETGRSVASVDAVKLPSSKWHWISDWMVDFSTPGSVDRHGWQFCNNINGPFHAHQNIRDNFRRRRWVRRCRLTVVGPWQTAGSLELVDVSIQVDPLMTSSDPVIMWAVGANGDVLCRNGVTASNPLGKSWIHVATALDKPFKSISVGGRYRVWGIASDGSAWYRAGVTPHNPAGKRWLQVVPPPPGNFVLHQLSVGATAVWAVDTGDNLWRRENITSTFPEGTGWELVASRVKRVNVGPTDQVWIVADAYFSKMKHGPGVIYNRVGISPSKPSGTDWEVVIGSGWAHVSVRGVTRQKQQSGDPSSKKDENWEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9L8</accession>
    <name>A0ABM1A9L8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein neuralized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106013117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943457.1">
        <property type="nucleotide sequence ID" value="XM_013088003.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013117"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858">
        <property type="entry name" value="OS05G0521000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943457.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="26686" checksum="D836EA7953CDEED9" modified="2025-10-08" version="1">MTLVPLPSRGDRPVLKDCVSHLIPLISSPGGESSMTFDLLLDVLNNLRFSDSGGQANEPQANEPQANIGGQSSEMSSAPSLPHLPPLGEVSPNEPANARSATVIGDIDEDSASDKCDGDENSASPSDTATTTTSTKTATATTAATTTSEEAGETRVSNAAGEDSQDQGQDQGQPPASVDSAAPARDGPEEQARLVEREHRYLVHRTTCIICQERTISCIFMPCGHVVACEDCAENASTCPICNREIVATANVYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9W1</accession>
    <name>A0ABM1A9W1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101852651</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943616.1">
        <property type="nucleotide sequence ID" value="XM_013088162.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852651"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046691788" evidence="3">
        <location>
            <begin position="21"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012943616.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="50990" checksum="4A03CE5F9FC60EF4" modified="2025-10-08" version="1">MSLVGAVIVVLLLMQGLVIPSQCDLDCYESHYWRRKHSFEQVMKEPIEEGRIVNRTCDLNRQSCIRWFAWHSHRQFILQCYIKEINNSSCGVVNSTFSSFSIRSDEKTGSSTLSFTANRQLKAVQCDYETKFGILTYSRPENLTCSSPEYTNNSNTVSVTCVTSDLFPTDPRCVLYRQTDGGSRVQTSLPPIYGSDTTGSVSGPSCTFTIQASELGAGTHRLSVNMYPQFDGSGVAYGKISTVSPDVTFYDSERNGYIMVTIELAIVTPLATFLLGILTSLALYCFVVKTEFFHKKWKPPKSRKPQENSEKTRAPLKYPVNIEKPPHNTVTGNRKKISATAGQQKEKQHVNMGSDFVMTLQDMTPQAEVGERHYSNVSVTSSASKAKKKGQSPRQGQNSKVGFYDVIPAQTRHLSASNVYQDVEPESNYSNVGCADGQSASAPDDGDTEEIYTNGSVCGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9Y6</accession>
    <name>A0ABM1A9Y6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vesicular glutamate transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943660.2">
        <property type="nucleotide sequence ID" value="XM_013088206.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854900"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943660.2"/>
        </source>
    </evidence>
    <sequence length="505" mass="56357" checksum="B5DF0EBE03C295DC" modified="2025-10-08" version="1">MKTSLYRKTCCTANSMLVSRWAKGFAETSPAETDLHDQARCGPPTSASAVQHKKRVDEIIQANRPIRLKEYLKGKPHADDYEIKEDVRRWFRGKPHEFFADGMRQLIRRWRICIDEEGNYVEKVTCLMLVMPTLYKLGSAPLVFALRVVHGVVDATVQPSLVFLVVAWAFKYERSRLMSLALLGSVLGPSLGNAVSGITICFVSWDFAFYLFGAAGLTWAAFWCLTIYSLPSECPHLEERELCHYDPDQIKVQSGSHEVARHIPWKRILLSKSVWAIWLGTFNKCWVNSVLTTLQPQFFNDVYGLRAADIGLFLSAQPLLNSVFVMLGATLADKLMYGNILSATGTRKLLQALGGYLEGFFMIAVAFSPDWRYSYAFFLSAYAFGGLSFNGYKVNRVDLSSQYANIVAGLSLTGSSGGAGSTLLASLILEDRSFSSWRIVAIVTGALSFACSTAYLFMASGERQDWDMERPPNKSAKDKSEDITTDVDDKFSEKDSLLDDSDDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA67</accession>
    <name>A0ABM1AA67_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943784.1">
        <property type="nucleotide sequence ID" value="XM_013088330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013217"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943784.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="42695" checksum="4938C55640DC9D8D" modified="2025-10-08" version="1">MASLTQQTSMVSLENTLAQVLRTLQDVQTRVKKAELLEDRMERLESGLGEMLARTVPFPRGAQGGGLPCCDPPCTQQLEDIQQTMSTHLTAITSRLDVLTSNIHQLTAVTEKNKTKTEELANSLLDTKTTNKQVATEVSRSVNIVAYIHNKITDNINKLSTTTSSKLTELSSKTNRQTDTLVDIQDNSLSKDELTEKLNKLSESADQQLSLLGSINNTFVGGAGVGGRDSGSGGSVSGQGATGGQVVGVPGLCGPAGNSHTHVLCVEDYSQWVGSGKIRCSDVWRVGVGRPEVRGVVEFGEDMTMVVCLNDRQCGCSVGSGDGGETCVRVTVTAVSQEGTGRDWELGSEEGEINGWSGEWEGWWEVTDLIFYDELERRGLVRGDRLTLRFDFCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB56</accession>
    <name>A0ABM1AB56_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC101854909</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6 7 8 9 10 11" type="primary">LOC101854909</name>
    </gene>
    <organism evidence="2 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089049.1">
        <property type="nucleotide sequence ID" value="XM_005088992.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089050.1">
        <property type="nucleotide sequence ID" value="XM_005088993.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089051.1">
        <property type="nucleotide sequence ID" value="XM_005088994.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089052.1">
        <property type="nucleotide sequence ID" value="XM_005088995.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089053.1">
        <property type="nucleotide sequence ID" value="XM_005088996.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089054.1">
        <property type="nucleotide sequence ID" value="XM_005088997.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089055.1">
        <property type="nucleotide sequence ID" value="XM_005088998.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944345.1">
        <property type="nucleotide sequence ID" value="XM_013088891.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944373.1">
        <property type="nucleotide sequence ID" value="XM_013088919.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854909"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF2">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="1">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005089050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005089051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005089052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005089053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012944345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012944373.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41638" checksum="5950895EAEBE3E2C" modified="2025-10-08" version="1">MRVLAWRRPRLFSGHCWRVVRLVLLLSMLFVLLVVPVRNAVLSFFLPGMWLEHSTLFLIKVALDFQHFPVEDAPLGHSPIRLQVDESEIQLKYLPRAPSFQEFYQQVSHLEQRARSSSAAQRELDTLLMFEPVMNPKERATALFTMDVFIRACKAANLTFFLISGSMMGVMRHHGMIPWDDDFDVAMNGSDWRKVRDVLSNIEGFELFAPAKVQWKFFLSSLPKGNRPFKWPNIDIFFFNEDEEFVWSQTWGGKYSLCNKKSDVFPLVVRKFELWSVPVPRRIGALLTAEFGDFHSECSTPAYSHKINVEVDSDMQKMVKCDKLHKVFPFVFHKAGSSSKTVLEIKMVGGHPISNATFPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABT6</accession>
    <name>A0ABM1ABT6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Decaprenyl-diphosphate synthase subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101854678</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110593.1">
        <property type="nucleotide sequence ID" value="XM_005110536.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005110594.1">
        <property type="nucleotide sequence ID" value="XM_005110537.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944702.1">
        <property type="nucleotide sequence ID" value="XM_013089248.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854678"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012944702.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="47708" checksum="2C80AEAE3FECA0B3" modified="2025-10-08" version="1">MSKTVLSVCDKCVRNLTRVNNSSVHHARTLSAGVKLSTKHRRRLATSQAPPVFSLASHQLSNPGQDNAAVWRSCQSRGYRFSWLNGDTGVSKAVSEAEKIVGYPTSFLSLRCLFSDELSTVALHIRKLVGTKHPLLKTARGLVFDGKHNLQMRGLLVMLISKAAGPNPDAEYAEQEMVSGVYPNQRSLAEITEVIHTANLIHKGVVNLRDVLPEDGPLSDLEFGNKMAVLSGDYLLASACTGLAKLENPTVLEKIAQSIGDMMTAEFTNFSDASGRPEMPDHCKGLSDWLSQTYLSIGSLVAKSCQSAMILAGHSATFQSMAFAYGENMAYAQQLCSDLLPFLRRDELSSLSLTSAPLYMYKEQATAEQFSRLQQLLEAGPDNYEKVVNLVTGSGVVQQCKDLCGQYRDKAIASLGCYADSEAKEALINMVTVVSDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACA8</accession>
    <name>A0ABM1ACA8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013536</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944974.1">
        <property type="nucleotide sequence ID" value="XM_013089520.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013536"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045983393" evidence="1">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944974.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15232" checksum="337FB93C981E447A" modified="2025-10-08" version="1">MRRDNLAVLSVAVLCLAVCARLVNATSDPAANACESVCWDENALADQCESENGCDVNVMSSSAYRTCARPCWAEVSACQLMCRARFERVLERCWPRCEEDTSENCVWNCFTNIVLSVKEKIRRRNNGTLVSPREDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD79</accession>
    <name>A0ABM1AD79_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho GTPase-activating protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945465.1">
        <property type="nucleotide sequence ID" value="XM_013090011.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862083"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057323">
        <property type="entry name" value="RHG40/28/18_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25442">
        <property type="entry name" value="Ubiquitin_RHG40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="323"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945465.1"/>
        </source>
    </evidence>
    <sequence length="690" mass="76706" checksum="EA174D2516341E43" modified="2025-10-08" version="1">MAASPSRELEEYWNEFHTIEQQHADTHSDEDELSKTPDEGEMEAAWLARAGYGFVVNKFQDGKDLSDGELDTLTHSLTRAQAEAVRKRINVLSTTMRRKNRVHKVHVKDIFPTQLHGHQHHNQHHHSGGGGDGGGGGGGGSDASGLMIRDAPSSPSPVHRQSSVGSGGKSGSEPWSSGLSQNKGGYSMSGGSSEITEDVEAGVETLGIHPRSGSRTQKEGDKFSNLPSVSDIEISLDFHLEETERPSSPLSTLPDPHRVDLPAFEPKPDPLGVTLIGDLAECDMDKIKSLAHIELTALFDHYSIVYSRPKRKKKMKDQGIFGVPLDLLVERDQKRSPGTDIPLVFQAMVNFLEKEGLTTEGILRVSGADTRAKQLRQDLEEKFYQGLFAWGDAGPHDVAVVFKQFLRELPVPLLSYDYLDAFPQVSSIPKTLEQLKALNLLILLLTDEHRNTLKVLLRFLRDIISHSNRNKMGLNNVSMVMAPNLFLATPLGKGEKADLELELKKAAGTSNIVKMLVHYQDILWTIPTTFIAQIRHQYTTEAHRKSKERLLSRLPWKKDKDRSDIYKKPPPSPDQPEVQDGVIRVQAPHLTKSSALIQLEPATTAADVVAKFKGGDGVLHRDDSTIGEMEETNGHTFRNPNNAQYAHDCDYLYEVGGNIAERCLDPRTKMMDLYHVNPLADWVIRKKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADX7</accession>
    <name>A0ABM1ADX7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101861557</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="RefSeq" id="XP_012945846.1">
        <property type="nucleotide sequence ID" value="XM_013090392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861557"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09539">
        <property type="entry name" value="SAM_TNK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049587">
        <property type="entry name" value="TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22931">
        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="164"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="431"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="702"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1424"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1508"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1732"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1795"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1838"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1947"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2028"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="982"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1049"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1314"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1335"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1617"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1732"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1772"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1805"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2028"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2038"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2075"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2116"/>
            <end position="2128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2149"/>
            <end position="2160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2189"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="2217"/>
            <end position="2227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2235"/>
            <end position="2244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2291"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="2302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012945846.1"/>
        </source>
    </evidence>
    <sequence length="2302" mass="250150" checksum="E003297530D1ED53" modified="2025-10-08" version="1">MAQSIGRSSSFGPDMGRRIMNQVRQMRSMSFRRSGSESVSAPSSPVAMRDLEEFLCEAELGEYYPALLSRLKVSTVEHLKYVQEEDLEDIGMSRPEMRRLKKFYRKEYPQGTFNKLRKAILRSSEGSNRTLSPSPPQQRSPRPVSGAAPYIRPPARQLIPADALSLNKVLGEGDFGVVQQAVWTTDSGEKVQVAVKRVSRERVNTDSQSLLKEAAIMQELDHEHVVRMYGVVMDTEENIMMVTELAPMRSLLECLKDPSLRVDLPLPRLCDYAQQVCDGMAYLENRRLVHRDLAARNILVFSKNQVKISDLGLSRLLGAGQDYYQSKFSVSLKLPIAWCAPECINFLKFTSASDVWAFGVMLWEFFTYGFQPWAGLNGQQVLEAISPPSEQRLEQPDLCTQDYYSLMKECWTNQPQDRPTFASMMLRLPQLRPTQVKALKDYPSPTVEKGYIYYKTGDVIVVIDKTPSTSSPPGLVWRGVLSSGKSGLFDPTNVVPFVEPKFSPINAKTNSLARKESGRKSSRKIRADMISRPQNDLRHTGHIGYDGAVFGDVSFIGDNYDKLPVKVEGGGASRGSSMTSISRCHDNPDHNGHIMPSNSTDSLDKPTSNNGYGQSWISRESLNSQSTFHSELQGRQSPSYLDVEDDSLFADFKMPDLGSSFDFGPSFMDEVLKALDEKEKQVTSPEATPTGAPAYSFAEEELKGRGGTSFPPRPAPRGELKSTSSSSSSSAPPLPSQPPRVETHKEKKQAKVKPMSASDERMVDTALARAKELTSHMIGDARQSPPVSPSSHDRSGFFDEDSPGIISKLKNSIRRSTSPKSERKRTFSEELENKADLDADMTPEAQQAYNMLVVRGSVKEGPSSPTVSSTSSSSSHHHVSDFVSSLEADSSKQQDWRGYGSRTRNFPEPEATPSPEPDLIRDSKRGGSPPKISAPFNVSSSSAQAGAGSGCGPPPPIPSSRPLISAPQLQPKPVGVSQPKPASQPAPVPAPRPVKQPEPPGKKSEIPVPRPRPEIQRVEPTVRHQMPESPEIPAKSEKRIDTHIPVPASRKEDSKEREREELKRTIEIVRVEDSNSYLRGDDSLEKVSTSFDRTSARSSQRSSLDRSDNTSENAESERAEWEHSEYSSDSSKPGRDSDSRANTSLSSVERRDSFNKKQTSLFEEDFSEPSPQEIMSKLRERRLNRHLDHQRALSGDGEASSSASAAGSSASSRPRPTAREPQGIPGRTASVDQDDGRADQEEEEVDTNPLRMLRGGAIPIRTAGRGSAGTGNHRGNRGATAAALRVPRLYFSSSHLSRTKPEGGQEQLTVGPEASSTHVLTAQGSPPRGHSSTPGGQSSTCVSSSSGRGSMSERVKVKGEESTAEFTRELERLTHTLMEGDLGEVASLVLADTPLDRGQGAQGELRKFSASGCQMDLSQVLPPTHAHTHPHHLPTTYYHNEQNRPAPAVPRSYGRDGKVESVVSPPLTPSWSQSGGGEILESVFAPQAPTWSRSGGGDRIDSIIVEGQIAPSQQSPVGDNRDVPPRLPPRRSQSVSEDPEKEINSHVSRRMLRRSNSLEGSDSPPALPPRDPQPAACRTPLNARPRERKHPLPPTTPQSPQPHTLPSSPWAEKRSAKLTSHSMMTRSLDSQMHPATPAHPSSQLSPPVCESKWSSVDLPPTYDMSVSSESHVVGETVADTEPTHMLLDPHMSHLSHQPLAVSLPPATDFTLPGEEPTHVSLSSITHNKHSWSAAFTSPSPLSPPSFTSTQQPPPLSHSSRMSPGKSFHRSLSHTYGQGGTTSSSFGVSLAFPQCPSLAESQSPPADLPPAPPTPSYRDKLGLDPPRTKVVRSISYTAEGVQPPNRPEELSLSHTTSNMRKRQKNCEEVETLLKVFPNEVSVEECTVALESSQWDVSKATKYLQLKQLLSLELADVHRCKQALLASGWHVHRAADLLLQQNNTLASTTTTTTSYTPTALRTTTTSSSSSPSSSLLCSSSVVEPVAVSASSNVLSPVSASLSSSSSSSSSSSTALRPSAESAVPVSASVSSSATAVTSPRQVSPTAVTSHAGTFPTKQPSPCPDAGVLDPRRPASDSPLQADTSDDVFTSQSDQSFSSATEEAPPSVTSFSVSRDSGRSSSGGLLDDASAPSSSRGVSFKPDIEKLEFEDTTWTSMPPNTTRAGHVTDREGTRSAGPFRTEAPWSARDAKSTSSSPWQPYSSEAPEAVDDFRKVKLRPSPRPSPRPAPAPGDLRSSKFMSRSTESIFTDVKLKPVAQREGFKSSDISKNAASVKSKSRSSDLSQIMNKFSVHTPASSTSARSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEH1</accession>
    <name>A0ABM1AEH1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transcriptional repressor protein YY1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101856314</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YY transcription factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946137.1">
        <property type="nucleotide sequence ID" value="XM_013090683.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856314"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017114">
        <property type="entry name" value="YY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037113">
        <property type="entry name" value="TF_Yin_yang"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012946137.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="42854" checksum="E4ACFF9BFBE01E7B" modified="2025-10-08" version="1">MASVIGSEVEIQEVEVEAIPVEMPIETVETSDEVSVQPMIALQPLPETAGEEIVLQTREEVVGDPNLVYADTIPVPAPEIEISAEEVIPMKKGKGGKRKGKSRNVVQTSNLGVSDLGLGDSSVKKWEQKQVQIKTLEGEFSVTMWASEDQSKLDEESVAGDSDADFTEYMTGKKLPPGGIPGLDLSDPKQLAEFASWDRIKPRKPTDDVPRTVPCPHKGCNKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKVDRSSKTMLVFSDQGSVDGDQCLSDDGLLVFDSRGQSAYQIPGTQAGQALAYVTIPPESPGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF70</accession>
    <name>A0ABM1AF70_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sperm flagellar protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106014042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946508.1">
        <property type="nucleotide sequence ID" value="XM_013091054.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014042"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF9">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946508.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33032" checksum="0C39974AB60E3C3A" modified="2025-10-08" version="1">MAQYVFARRGYNGITRVDMEDYFDDVELESLYQWVDRVPLSRPKKNIGKDFSDGVLVAEIIKHYFPRLVDIHNYTPAAAFKQKMENWYLLNRRVLRRIELDLSDDVIRALSNCKQRVVEKVLMMLRVQIDKFIEKSNRLRLKTLQIQNALGIKDAMDTDLDAMSTASPKPVTGQELVPYNNKAKSPRLSMSLPNVMPHSHPTRSTYASTRSVLTVAPATDNISKVMFEEKELECLAKDETIQILNAKLKRMEQLLHLKEVRIEDLESRLHHVQAIKMAQFTDMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFE3</accession>
    <name>A0ABM1AFE3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106014102</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106014102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946604.1">
        <property type="nucleotide sequence ID" value="XM_013091150.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014102"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012946604.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17143" checksum="15B80DAC1A61A6A3" modified="2025-10-08" version="1">MPCETYSLTAVYPNSTAFNAFISHSTPDVRHKEALLAVRLNTTRLLHSRLAWRPDMWAELTSGLEGKATRAGIRAAENWALLNAAVADEFAAKYGAVSSSVKEELSPLIDMLERELNRMAYRMNDMSRDLSAIYQRNDFYAQDMGVVYTTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFI2</accession>
    <name>A0ABM1AFI2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual specificity mitogen-activated protein kinase kinase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101855850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946652.1">
        <property type="nucleotide sequence ID" value="XM_013091198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855850"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012946652.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8663" checksum="314A493BEE0D5940" modified="2025-10-08" version="1">MKIIVEEPQLKLSDEQFSPQLVDFVNKCLNKMPALRLSGQHLLSHPFLQSQPGFDPSVISQMVMSRQRPAHETMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG30</accession>
    <name>A0ABM1AG30_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946952.1">
        <property type="nucleotide sequence ID" value="XM_013091498.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860235"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="106"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012946952.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="60964" checksum="6DCC422227F9EE62" modified="2025-10-08" version="1">MEKPPSDENAQTLSPPPGEPPKQQEQQQQEQQQSLLTPAAAAAAVNLHADGANGDGGCDASGCGGGDLVKRRKSASGVADGVSGIGWTRRRCSRCGVAVTSCPHVLRAPTVIAMVGLPARGKTYISKKLTRYLNWIGVSTKVFNVGEYRRAKTNMYRNHEFFRADNQEAQELRSRVAMLAMEDAAKFLEEGGGEVAVVDATNTTRRRRDILVDIFTVQRNFKLFFVESICEEPAIIEANILEVKVCSPDYDGMDKNTALEDFLKRIEHYKDEYQSLDYKHDKDISFIQIFNQGERFIVNKLAGHLQSRVVYYLMNIHVLPRTIYLTRHGESQMNLQGRIGGNSDLSDQGEIYAKELADFVKKENIPNLKVWTSELKRTVQTARHIDAPKEHWKALNEINAGICEGLTYEEIQAQFPQDFADRDQDKYHYRYPSGESYQDLVARLEPVILELERQENVMVICHQAVLRCLLAYFQDKSAHNLPYLKVPLHTVIKLTPVAYGCRIEFVSLNIPAVNTHRDRPENVTRNRSSCEALVTVPEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VP05</accession>
    <name>A0ABM1VP05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger CCCH domain-containing protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824147.1">
        <property type="nucleotide sequence ID" value="XM_035968254.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852658"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039062">
        <property type="entry name" value="SPAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031478">
        <property type="entry name" value="SPATA1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14421">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14421:SF3">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15743">
        <property type="entry name" value="SPATA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 1 C-terminal" evidence="3">
        <location>
            <begin position="560"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="654"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035824147.1"/>
        </source>
    </evidence>
    <sequence length="750" mass="88483" checksum="9D2E2C311FF9920A" modified="2025-10-08" version="1">MYTKGRDVGGGGGRPNDVEKLHLHRDDSTMTQLCDLHVYKVPTQLWRESLNNILNNVVTETVSVGIIRVPLDLRLAHIRDELAEQLQLDDVRDYVFLRSVGRSLTRLRGKQEYQLKAKHFIPPVAYAPELYILEATAEFRDAMAMSERMSQSPPLSRRTSPSHRGYYRNGYGDSDTERGHKPPHPRTSPPPHKYPALPQIAPDTAHLHPSDDNARNDPYGQRPSTQAPHDPYHRQHDHKHDPYNNNTQQQQQQQQHPYADPYGSNINTDTYRKSHADGDPHQYSRKNIAYSDEDLANEAFGRPPPLQDYLSDKTGAPRDGQPDTQTATQSYHASDPMPRPLGERSPSPRSKASPTRSAEKGRERRHDDDSGVAGLTPEEEYNRRNREEYDSVMSKNRDMQRRLESERFGLDDETEAERRRRLDDVESGNEADRRRWDADQEERKRQADIDRRKQEEEEEERRRREEREKREEEERKAREEENERFRKDEEEERRRREEEEENRRQREERDRREEEERQRNRYEDTNRFGSPAPDASSDQVRDTESARQRRRDERNQLLKDLEDAKLSRQDQEKEREELVKKAKSMQHKTTNRRNEARDMWKKKYFEEKKKTAPLEESSSRLRQDLEALHRRLMNTLEGPKEKNLKIVDNKPSRKSNYVIQCTRLQHEIEDLQRRVENARMKLTAEMKLRNQAQGELRALRAELTQKKTTLTSSRQQAPPILVHHKEPFGGKENEPPVYMSHRINASLNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRE9</accession>
    <name>A0ABM1VRE9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger homeobox protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824991.1">
        <property type="nucleotide sequence ID" value="XM_035969098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861434"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051968">
        <property type="entry name" value="ZnFinger_Homeobox_TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24056">
        <property type="entry name" value="zf-C2H2_ZFHX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="829"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1201"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="870"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035824991.1"/>
        </source>
    </evidence>
    <sequence length="1357" mass="149308" checksum="B148E55B85A31A3C" modified="2025-10-08" version="1">MSATVDLSPLKMETPSPHPSPHRGTPLRSSSLGSPREEDAMAPTSSPAGTFSSSIMEFGRVDPSPVYSTSGSDSVMRNGFRPVMDSEMSGEPMSVDDDSPPPSPSPSAKAGPESVETDRPLTPPATFPATSNSYLYGNAPEPDDASRDVSSPSYRSPSLPDTRRAQHSPLESEEFPRSPSPDVREVERPAESMSSDCIQSKPDDSDDVIDCCDDDSSAKPTSEVEPSRRGSGDNGDVSDKEEEDQIECAECSVVFSNLQRYMDHTCYRSHPAAPVPPSPADLTTTVSGRAERHPVKTPPISSPYDFRDEPKSDTRCFYGNMVYNPDGSVYVMEAGRSSSDGDIEMARLNIPLSADSILVKRHQSVLSVDRSIPQLTTAVFFPTNGPSSVLSACLDNPDSSTDPHNVSQSSLSFKVFCLQSVPAERLLHHLASHPRRRFPARSVLMCFICKLFYELPKTFLKHAMLEHSILFNDSEKTLIDLPSTSAIIHAVGKMKEPMVSVLQPCVRHESQRIVDRTESGPYSFVSSRDVVHPTLSVNLNYMPPGIEDKDSLNHIGMSSFDSERRASSDRVSSYKHSPLSLSQREELSSIQRSSTPLNMKGNNFLKENYYRPSPPVPSPGDKPPTGHFLLPPHSIAMDNPSALALRSSPSQRVSSSPAASTTSGPPDPSFLTSAPSSLSHLVTASSLASSVRVLPSSAPANLPPLLTLPSSAQTSLPPPLGLTLPNFLGGTCDEHPQGKAQGVECPKCDMILSSSQSLGGHMTMTHSRNSCKTLKCPKCNWHYKYQETLEIHMKEKHPDSDAQCVYCLTNQAHPRLARGESYSCGYKPYRCEVCNYSTTTKGNLSIHMQSDKHINNMQDLANGSAELKMTAQQPTTAQSLPPSAPPPIPPTNVPPSSYSQEDQQYKKLKQKQSFRCDVCSYETSVARNLRIHMTSEKHTHNMLVMSQSISHLHQDMTLHQMSQMNQLLALNQQDHAARFAAMGAHIPGNLFYEQAAMLMSAAASNVPPPPHPPHHPPPPHSAPGFEIPMNLTKENGFDDGCGGPSNNKDASKMFQCAVCNKYSSDSMENVHNHIQYDRTKNGNPDAHVTFSNGTYHCNLCSYKTHLKANFQLHCKTDKHLQKLQLINHIQEGGLENEWRLTYPGSPMQICCNACSFYANSTHKMQLHASTIQHESCAQLFRHLQLLDRATPPAGPGRQRFYQCTLCPANVRTKQRLVLHSRSPQHVRKEQLMLQGQVSIFDVYVIKEMTDGDNVDFEEEGKFVSLSMSLSLQITDETASCVLQNRSEISLETMGELFQVRLCDTDLEKDNCSVVDLRDVQSLLQNIGSNVWRRLSNMRTGSGDSEEMSHSLTKAVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRX4</accession>
    <name>A0ABM1VRX4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101853080</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101853080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096678.1">
        <property type="nucleotide sequence ID" value="XM_005096621.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825166.1">
        <property type="nucleotide sequence ID" value="XM_035969273.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853080"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="1">
        <location>
            <begin position="60"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005096678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825166.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19363" checksum="405390FC043FB7FD" modified="2025-10-08" version="1">MTPNKLILNWRPWKFSVASSSWFRLGVPSTGKRWQRPRLLSPSMSYKVNYLIDEGVLVGKGSNTVISLLHHFFETHGLGESAVSLHCDNCSGKNKNGFVLAYLRRRVLRGLHTEITLNFMIAGHTKFSPDLCFGLLKRKFQQAEVHCLEGMCRVVEESSSVNVPQLVETED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VV91</accession>
    <name>A0ABM1VV91_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endo-1,4-beta-xylanase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826333.1">
        <property type="nucleotide sequence ID" value="XM_035970440.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860256"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.690">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041254">
        <property type="entry name" value="PCSK9_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041051">
        <property type="entry name" value="PCSK9_C3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF1">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18459">
        <property type="entry name" value="PCSK9_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18463">
        <property type="entry name" value="PCSK9_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="7">
        <location>
            <begin position="272"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035826333.1"/>
        </source>
    </evidence>
    <sequence length="824" mass="90680" checksum="540806D9F1578743" modified="2025-10-08" version="1">MGKTEEGQFYRKIQILNLPVFAAIFVLVLSNGVVTRAAVELLKNPGFENGVTFWSHIGFSMVTTTEQVHGGRVAVKCTGRTQSWMGPAQDIQISRGKHYVFTSYIKLINDLPGRMFQKAVVKISFTLKDGSKDYFPICSRTFLTKDDGWTMVGGDFIPPNYEWTQASLYLEGLLPGTDYYFDDASLTELPSNPNWEQEANARIENLRKSNLNVNVSLSSGFRPEDVTVEINHLKPLFAWGSVAGPDEFLSSDYAQFQQLYYYMFNWATIQDYKWRFNRGNRTNPDYRVAVAATDVLNRNGIKVRGHCMFWAVPFNNPEWVKGLAAPEFKTTVDDRIAYMTAQTKNKLAHWDVNNELLHGYFYEEHSGNPLYSEHMFREIHAADPNPTLFLNEYNVVKSGEMTQSYLSQIQKFKAANVGLGGVGVQSHLNDYEEPNPDSINYRLDVVAKGGLPIFVTELTLGAHDPNDKADCPGRLCQQLNESGKRFLKLTKETWSTHVNRSLASGTSFNLRAFQGDYEAVVWYKGKPIKRTTFSLGTQDKTVSISVSGNGDAIQLPKKIDPFTMNVQINPQTTRANLRTLGQASSTSQNSQLTCTTRRSPASGVGVGKTTQVTCQGDEVLTGCSSWLKDSDWHRDGEEILMSGGKQACRAMNGYGSAAGVEAVARCCSAQGLRCEYRTAGPSGTGMDDKVEVPCQGQAYALGCSTFTYTTHSDGTIFTNTSCMGQNDNLRSGVNSYAACCQSPNLQCRTVTSGTSGKKISDQVGVTCPKGYVMTGCNVFAQYAKAAGAFINTNAAGTDTCVAVNGAEKFGPETGVQAQATCCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWR0</accession>
    <name>A0ABM1VWR0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Gonadotropin-releasing hormone receptor isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14 15 16 17 18" type="primary">LOC101850580</name>
    </gene>
    <organism evidence="10 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940604.1">
        <property type="nucleotide sequence ID" value="XM_013085150.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012940605.1">
        <property type="nucleotide sequence ID" value="XM_013085151.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826848.1">
        <property type="nucleotide sequence ID" value="XM_035970955.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826849.1">
        <property type="nucleotide sequence ID" value="XM_035970956.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826850.1">
        <property type="nucleotide sequence ID" value="XM_035970957.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826851.1">
        <property type="nucleotide sequence ID" value="XM_035970958.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826852.1">
        <property type="nucleotide sequence ID" value="XM_035970959.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826853.1">
        <property type="nucleotide sequence ID" value="XM_035970960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850580"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF59">
        <property type="entry name" value="ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="126"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012940604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012940605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035826848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035826849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035826850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035826851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035826852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035826853.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="62594" checksum="E2C9F6F0C60864C2" modified="2025-10-08" version="1">MDGTDSDGSILQRANQAFLASSSGPLQLPIPYNFSAQNSSVHRKRHDVYSPRSAHHDFILASDNISSLLLNTTAPNMISNNSSFEFQFLNTTHPSNVTFENAPTFTTTSLIKTIVFGIMFGISFVGNMATIVQMRRLRRRKSTINTLIVNLALADLLVTFFCIAGEAAWTVTVQWLAGNVMCKFVKYMQVFALYLSTYITVAISLDRCVAILDPMRRNGAAQRVRTMIVFAWIFSALFSIPQPIVFNVLRGPFKEVFYQCVTFGSYDSAWQLQMYAIASLMLMFVLPLAVMGTAYGLIFTTISRKSKEHSVMDSIQMPARKTWVTRWVNYKRYLCMAFCSKPISRRSSIMSNYSEDHAARGPVRSYLLRKAKRKSLIMSFVIVLAFMVCWTPYYIIFICITFLDKVIDPVIFNYFSFIGLSNSMLNPMIYGAFQLCKVQFYNPSSWRRNVWRGTSPKLQSSNPNRRSDFPPGTPASSSISRDSRNRLLGQGQGCHCQTCHYEAKEQKVCIPALDRKAQASKTSTKSSERCGKFTHKHFTNGEVKHCLCFHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXM7</accession>
    <name>A0ABM1VXM7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein MON2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827170.1">
        <property type="nucleotide sequence ID" value="XM_035971277.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851518"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34199:SF4">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34199">
        <property type="entry name" value="NUMOD3 MOTIF FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HDS" evidence="2">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="3">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="3">
        <location>
            <begin position="151"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827170.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="53821" checksum="62EBCFB39EE681A9" modified="2025-10-08" version="1">MCSWGAEAVTSLVKAALAYKYETPLHENLKLQSAILAPLRALSSIAYNDIRQKQLESVSHVLQNNGDSLLHGWPLVLEVIGAVIQEHGEKLIQMAFQCLQLVVTDFLPIIRAAYCQVVVQVAAKFGLQQQELNVSLTAIGLLVSQWWYFLSLLESVLFPLLENVQKFSSSASTIRDKESTGNILIHHSRDTAEKQWAETRVLTLAGVARTFNAKRKMLQGLGDFPRAWSLLLEHIELSALCQNAEVSLAALKSFQEILQIGRATKGSEDGESTGPSLIEPPSSEVMNRTGDAAGAATGKKANNELCSKGPISDSADHDIPLWSAAWKVWLNIGTEVTKPPSSQNEERPTGGAPSPRVYLPSQNFLTALIQTFPPLFEHIKSRFVAADLHKLSAVLKGTLCVPVQSDASPFIVPSYTEATVTPLQEASLAAMEALIKAVQSGPDNMQATFPDIFQQLLTFISFGVHAPKFGDLEAKTFGVVRGPQVRMIDCDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYL5</accession>
    <name>A0ABM1VYL5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Proton myo-inositol cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101860595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827508.1">
        <property type="nucleotide sequence ID" value="XM_035971615.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860595"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035827508.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="81115" checksum="47139DE372E36898" modified="2025-10-08" version="1">MSTASSSSRSQNSFARPTKLTGDSDDEKTDLRLKLDSLNMRVQTPTYIYVLTFFAALGGFLFGYDTGVISGAMILLRNSFSLSSVWQELIVSVTIGAAAIFALIGGFLNDRLGRRPVIMGASLLFTLGSVMMAVAKDKFALLAGRIVVGAGIGLTSTTIPMYLAECSPSYARGSLVSTNIAMVAFGQFMANVVDGIFGSDPKNGWRYMLGLGALPSTVQFLGFLFMPESPRWLISVGREEKARRVLQSMRGALDIDEEYENIKQSCTELQQEEQNRESWHWFRDPPRPQFHFSTFYVDSLRQTTRPCSVSQRRRLQCEALKSLGEIEWSFVGPHFDDSISETFMSPEKQRYKLLSCSLNILVSFMFRALVYTNIITTSLIHPHPSRKQSRSIPSTSPPISVRQDTILIYKKTQLKTVVSTPRYYSATIIRMSGVKSDEAAIWLSAVTAAVNFLFTLVGLYLVERIGRRPLALGSLMGAIISLAWLAVGFHLSALNTPPIDLIEHGTDAYRCSRYRSCNDCRRDLDCGYCYVDQPDFVTNSSCLPTSYDNPWTATVGRCNSSTLQGGLTWAYDYCPTPYSWMPMVGLVLYLISFAPGMGPMPWTINSEIYPLWARSTGNAASTFTNWAFNLAVSMSFISLTESLTRYGTFWLYACLAFAGAIFLAIILPETKGRTLEEVEGLFARSFFSRSWFANSADPIQPLNPQSIQYVHIRGLNRDGRESELDSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZC4</accession>
    <name>A0ABM1VZC4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101860682</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101860682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827767.1">
        <property type="nucleotide sequence ID" value="XM_035971874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860682"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035827767.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="72545" checksum="07D7484C111F7E68" modified="2025-10-08" version="1">MNSPEAFHMEMIKLLGTPPKLSSGALLVKCATEDGVTKLLDTTTFGGIPCKYESYQKFNRSKGVVRSHELKGCSMKEIVEHCEFDLTVLTTGTIYPGNSVRLQIKYSYAERVRESFTARIKTVKGQNREWSCQILKEFEEQLEIKSAGDIEYYARTFSFTFPIAEAYYVDVQSSTSHASTYVHVMEPLISDSCFLNSRIMSPSTNLHANMVDRGQEILLKMEPYSETGPCAGVKLRWRFYRIDPLFTSETCEGPTLIRRFVMSMYMGQRTFIPANVYLNQKTVLLPANAMPPSNMMITVQWTFAKYQLYSYFSRTIVKFRALTNSAQVIRMSGFPIVDTLQWPTGADIQLDYSESENTDFTPESCSRLPNQLTFHIFMSISFPSQGYLSTELQQFSKTGKLVLPGSMLRQVNQTFTLKLKIISPTSEVVMRINVINLPQIPKIILRCYLNCGSVAASSAAIIFVAFCSDCSRPEHTFTTWTVYDENGETLGVYSSQYAVLQNLPPKSLWVLNVTLTTESGVAHTAIVSKHVTTDKLEASCTVAAPTLLSVNSLYSIWSFKPIESKNLTASQHPYVYQVATFDTDNRLSIPLIRSFFESFPTVPLETRRRGERSLIWVTMCSAYGACNDARAGSSFYLSVSIVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1A6</accession>
    <name>A0ABM1W1A6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase ULK4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101848322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828449.1">
        <property type="nucleotide sequence ID" value="XM_035972556.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848322"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14010">
        <property type="entry name" value="STKc_ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056981">
        <property type="entry name" value="HEAT_ULK4_RUNKEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045906">
        <property type="entry name" value="ULK4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46240">
        <property type="entry name" value="SER/THR PROTEIN KINASE ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46240:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23606">
        <property type="entry name" value="HEAT_ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828449.1"/>
        </source>
    </evidence>
    <sequence length="1319" mass="146211" checksum="3CD98AAE0A9E9923" modified="2025-10-08" version="1">MENFVLYEELGKGDNSVIYKGRRKGTINFVAIHCIDKCKRPEVTNTVRMTHDIEHSNVVKFHEWYETSNHLWLVVELCNGGSLETLLTQDGNLPESSIRSFGVELVIGLHYIHSLSILFHDLRPSKILLDTEGILKYADFSLAKVEGENLEELFLKFAEAGDQWSSQTAEEVMKYNKCTGAVMYMSPELIQGGDANVLSDLWSLGCVFYHMFAGHPPFLAESEEHIKERILTKDFPVPKVKDVDPHGSCDQFVPENAGCSSRLSAKPSPEFMSLLQGLLNKDPQHRMGWPDLVSHSFWKGELNHLAKDFSSTLPEVHASSTTITASSVFDHGGGSALGKVKGVDLRRSMERPVAQLDTVDGSRPGTGMGDYLRPKTAPGMESGGSLFTLSARPHTAVPPDERLTSPHMATQAPLTTREAIGYTTDGEASLQDTGTETKRLIFHDSDFVVTQIVDNPKIQKVAVCKYDSKTLPVPPFTLDKLSGLSEKEILKHAKAITDNISQVEKGPPSQKRIQLLHYVSCVASCRLLSTALTQNGIIGAMTKLIRESSHLDIRVKFSRALALVAHFTEKIDTSVNLSESMSTLSEMLRENMKNTRLKQGLLPALGEVIALVAAQEQRLQESVEAWAVPSIAYTTIIRGIREGALGAEDDQVLNHMAAKIIETVTATRSTHAQKFVTQEVCQSLWYLFKHSAVDSVRCTAISALCRLTWHNAAMFQNLLDSGGLTPVMQALTGGVSRVQQAVITMLGLFMVTVGYTNRLFQDKDFRSKIMRCFESPSSVIRGKAFVLIHEMVHNNNELLLSCCQARLVMYIERDSRRQTPRTPKSKPVEAQEYLNQCLELLVSGVVHRLPSVMDEILDCLDQVGGRKHPSTVQAKQLKTSLPLLPIFNHLVTSQVFRPYIVSRDFLSQYVKLLEHVVKIETGETNIEAASEKAKASISVAEFVGSSLSVLEGISQHPPLLIEHNVVVMETVLPQLAALVACQNVDTKAQALHLFGEIASVFLTQDQFGITDTRVNTTQLHAIISEKLLPQFEPILLDLDPLPSYALKLLLALLEHNPAFIKQMEAQGLVVVIFQVLMDHQNNPLGRVMQGVVAVVSCLVSHKETDMRELYDQGLIDHLTNMFFEVWNSVCEGEEGGRDVKTAVTMLFTLLDTLSAILRYVSEVVRKALQVKNKGGEGSQKEAEFGEQLLMMNKSLTDLNSLLTQLLCYEDAEIQDLSIKCLSLLVQLFGGESREAMAPDNMEYYSKALRTTEAKKQKVLLRVIKRLLTTDSRHLESMKKHGDKLAKTIQSLADTASSHADVALTTVAAEILRMTGHISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W258</accession>
    <name>A0ABM1W258_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC101864102</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101864102</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828751.1">
        <property type="nucleotide sequence ID" value="XM_035972858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864102"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035828751.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="42376" checksum="4C45F15D51854D1E" modified="2025-10-08" version="1">MYTFICTVRARRATAIYTLMWISGWASCGRVLQFKIYCFVFGWLGSALVVWSAGIIVIMTSCRYLSLAKPLYYRAHVKPRRVTYAAVGTLVFCLAFFIFPFTGLTSPFVVYDQNNVCATDFAPGSGGVGQRIFIGAIGVIGSLTVLHVVVCNISIARTLRQRNEVRVASSVTAITEPRSTSLVLGRRRIFGRVTLVVSFVYALCYAPFVVSFACFGFQGGDDGGSDEKGSGLANAAVAIVVMVGVVLRLLVDTVNNLPHQNNLIHSVTMSLLFLSPLLNPIIYGIFNKQFRKAFFGLFHLRVKFSPNSRTRSGTADPRVHNRHSSTRGGANRGTSNRGEMCNRKSSANQLAAEQSFARGGGRSLCTVTVTTTIMDNYSEYSPTTVNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2B2</accession>
    <name>A0ABM1W2B2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium-dependent phosphate transport protein 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101848002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828805.1">
        <property type="nucleotide sequence ID" value="XM_035972912.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848002"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01013">
        <property type="entry name" value="2a58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037997">
        <property type="entry name" value="Na_Pi_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="646"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035828805.1"/>
        </source>
    </evidence>
    <sequence length="713" mass="77959" checksum="9759314413A7C8BF" modified="2025-10-08" version="1">MKFFQRTKFRPEPMGSSVLMTFFAQHFTHMFFKTDYKKGHGVTWSGHGVPNGHDAATNDMENGDVSKGKLEEQDGDTDSVAFGDMTPSQKCHSVTKVLVKVALFLCCLYIFICSLGLLESSFQLLGGKTAGTAFSSGILSNPLAGLMIGVIATVLVQSSSTSSSIVVTMVASGIIPIKKAVPIIMGVNIGTSVTNTLVSLVQASNREHFRRAFAGATVHDMFNWLCVIVLLPLEIAVGYLYWLSGLIVDSMVLEGNNEKPPDMLKAITNGFIDAIVQIHKDRINEAAASSNGTEVGHVLKRWCVKKTISINQTSLHPDDVFVDCYSLPPDSPLNQTCELALADPLTDGRNVSLTVQWTSVKEINFTQEVERCDSLFSQTDLSDAAAGGILLVISLGLLLGALLLIVKLLNSMLSGSVCKVIQKTINSDFPGPFAYFTGYVALLVGCGMTIIVQSSSVFTSTLTPMVGLGIVSVERMYPMTLGSNIGTTVTAILAAVSQSGEKLRLALQISLCHLFFNISGLILFYPIPFMRLPIGMAKVLGKVTSKHRWFAIVYLVFMFIIFPGSVFALSYAGWIYLGAVGGPILLIFLFIVLVNALQKKKPRLLPTKLQNWNFLPVWCHSLKPIERLIERVFRCKYCQTLQQASKEDNDDESGTDEIDSIEDKTHVPDFSQSQDDQQTENSFKDNQYRNGVITSDKENLGVVNNGFKSDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2M7</accession>
    <name>A0ABM1W2M7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 13">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101855064</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 13"/>
    <dbReference type="RefSeq" id="XP_035828920.1">
        <property type="nucleotide sequence ID" value="XM_035973027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855064"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="309"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035828920.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="68264" checksum="BAFAC60497E291EC" modified="2025-10-08" version="1">MLKMKRRKRVRESGSDESDQSAENESDSERRTRVTRSAASTTATGGSPLKESPPVKRRRIIREPVQLESDSEDAAECGASKGGVKGKSSYKGKVKLSGKRSTQAKAKAPVLSNGECNEDEDSEDGQSLVGYAERRVIPKTNYDETSAHCPLPGCDSKGHLSGRHESHRTLTSCPLFHNTTAEECKRRFENRLKHVEERKKVVAELKDRRGLRHQVLSEAQKEKHDRIIKARSKKPEITDELKEKHRKHKEEYGNTRQPLVTGLTSDYDYELFKEAQSRACELLKGLGMYSFSLCQQEHQLTQHFAKSDLQEYRIKKLEIGRFEINTWYSSPYPEEYARLPKIYLCEFCLKYMRTATILRRHMAKCLWRHPPGDEIYRKGAISFFEVDGKKNKVYCQNLCLLAKLFLDHKTLYFDVEPFLFYVMTENDSCGCHIVGYFSKEKNSFLNYNVSCILTLPQYMRQGFGKMLIDFSYLLSKKEDKVGSPERPLSDLGLLSYRSYWKDVLLEYLHKYKGQEICIKDVSQETAINANDIVSTLQALGMLKYWKGKHLVLKKQELIDEFLEKKASRSPDLANKVIDPTCLKWIPQGKRGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2Y4</accession>
    <name>A0ABM1W2Y4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478826</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829027.1">
        <property type="nucleotide sequence ID" value="XM_035973134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478826"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829027.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34950" checksum="7B6BD76BD493A68F" modified="2025-10-08" version="1">MNRDLSRGQCDCELLGRIQSTTRCPSSVSLVITDSRWRPNVVCNRISFAIKMIFEHVKTYFQPSKLTKAYSKMKGQAAKTFNSDCPEYAQKRIWDQSEPETPSLPIYANNRDLEQTQPVVESQKRNSATSSGKWCSHNVSFPNQSEEINRRGDGAGQGNKSKCCYCAWVFAALVLCILFQQCQIASLKETQTEFLQLLREMEARMAEPAEAGNSLQSAVFQGSSKRGFLDYLKSTYHDERRRPSRQTIEDTAGTGALLNHKKTRRSIPSLPSGQDSTGHTVVKLYKNDPYLRVMGMVRNIVNNANEVSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3W4</accession>
    <name>A0ABM1W3W4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP synthase subunit C lysine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANT/ATPSC lysine N-methyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829357.1">
        <property type="nucleotide sequence ID" value="XM_035973464.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859457"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610:SF9">
        <property type="entry name" value="FI06469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035829357.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27230" checksum="9E97E0B1AE7B3E58" modified="2025-10-08" version="1">MNVAKSSPPPPDPLTSTRLSSPGATVEECDICAELSAAGKHSQPPKLSRRGAVMLGVSGAFVAGVTAVMAPFVLPGLRRFALPYIPASSEQVSNVLRALRGRTGSLIDIGSGDGRITIAAAERGFQASGVELNRWLVWYSRWVAWRQNVHSETNFFRRDLWKTDLSCYKNVVIFGVETMMPDLEEKMTQELVPGTAVVACRFPLPSWQPSMTLGEGVDTVWLYRTPAPRLDDACTPSYAESQDKEDVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3Z2</accession>
    <name>A0ABM1W3Z2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 13 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106013802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829385.1">
        <property type="nucleotide sequence ID" value="XM_035973492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013802"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035829385.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33112" checksum="19835BAF0A7D8262" modified="2025-10-08" version="1">MTTNPKMTNLSPEDIFADVDGCDPRSNGRCRRDNDNDKNNDNSRDNSNDNYNAGSRGPEEADTEYQRLCKGLSLCVAYAANTGGIATLTGTPPNLVLSGQADSFAEVMTLILFVCLVLLWLSRQPEFVSGWGDLFREDYVSDSTCAVLIGCLLFVVPAERPRVFCWRVTAVTSPGEGQPASYRPLLSWKVAQDKLPWGIMLLLGGGFAVAKACTKSKLSDWLGDQLATFDSLDPWLLNLVICVIVAMATEVTSNTATATLLMPVTFQLARRLQVNPLYLMTSTALATSFAFMMPVATPPNAIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3Z8</accession>
    <name>A0ABM1W3Z8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101862317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101862317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035829391.1">
        <property type="nucleotide sequence ID" value="XM_035973498.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862317"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035829391.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23533" checksum="59C6CF51AFDE89E8" modified="2025-10-08" version="1">MKIKFIFTTRRTSCALILIYVLIIVCDVPKYTVILLVWKHSPVDNSTTLGLEFTRRKERVFSAMFFLNNFLPSTAFVVTSVCTVVLVATLNKVSKWRQSSAGIAKNEPGNNVMSSKDRRVSVMMVLVSAVFIVCYLPGLVLFTWMSLDQDVRMEGRKSHIFLFMTGVWTTMTAINASANIFIYFTMSTNFRRVFFQMIVRRQISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4A0</accession>
    <name>A0ABM1W4A0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101847932</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005112992.2">
        <property type="nucleotide sequence ID" value="XM_005112935.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829493.1">
        <property type="nucleotide sequence ID" value="XM_035973600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847932"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF3">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="699"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005112992.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035829493.1"/>
        </source>
    </evidence>
    <sequence length="1064" mass="121834" checksum="45F2B14E1C7315C8" modified="2025-10-08" version="1">MFSKVGSDKNKFLEQAKAARLERAQDRNREEAAVKLQAGIRGFLTRQRVKRTFREEVDSFLQIPPPDTEYKPTLKPAIETFHVVKKLHFVHDVHSEGDQKRFEFMCRYILASMDTDSLKNCYVAVSFNKNLTLLWIAQLKTVLWTCCQYFYSLRPENHKDLRTIMVFLRMLVTFTAHNNWVAFKDKEALHPGFTKLCDNVMGDLNSRGLYTALEALLRKGLCRSKPAFNKASLTAIITISLRPLLSANFSNNLLSIFLLHILSVPAVVYYINTIAQDCVATLVTHRVFKRCLDLLTIEQSTRIIFNSLEGNYALCLMANLVQLGYVEMEGLVENTVDFMTVMIRLLENCNKYVQNKKSNLTHWHPVLGWFSQKTDQSLHESMPLVVRQLQLLWSDRMIRLMFAVLLEYTETSPVPDSQSVSSKKNNILKKALIKASSNKLSSSQRIKLDSGIAFSTCLPCSLYRHAVTTLTQLSMDILGGLAYNNVLLPILWRFLCDLGPHCGLKTFIDLLSQAPGSTIHPVFSLLSLFCETASHMITTLDVIEMLEQQKVFKVADYVKMGEFLNLFVFRVIWGGLISIEQAPTSNVFTSALNLLMILHERDSRRSFAPTNHWLIREVKPSHFMDELEKEKKTAKFLMQRVPHIIPFNERVIIFRKNVLRDKENLRLLESAHTSVQSTLITVHRIRIVEDGYRQLAQLPSRALKGVIRVRFINMMGLEEAGIDQDGVFKEFLEETIKRVFDPHLNLFKVTSEQKLYPSSTSYLQESHLALFEFIGKMLAKAVYEGIVVDVPFAPFFLTQILGHLQSATYSSLDELPSLDMELAKSLSYIKHYDGDVSDLELTYSCDEDILGQVVTHELVPGGKAIQVTDENKIRYVHLMAHFHMYRQIREQTLAFVRGFESVVTPEWLGMFSAPELQKLISGDSESLDMEDLRHHTRYHGGYHNNHKVINWLWDVVDNDLNLEEKGLFLKFVTSCSKPPLMGFAHMEPPFSIRCVEVSDDQDTGDTVGSVLKGFFNIKKKDSVWLLPTSSTCFNLLKLPNYPKKSILRDKLRYAIHSNSGFENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBD9</accession>
    <name>A0ABM0JBD9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">T-cell acute lymphocytic leukemia protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089768.1">
        <property type="nucleotide sequence ID" value="XM_005089711.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852219"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19708">
        <property type="entry name" value="bHLH_TS_dHLH3B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF15">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005089768.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9799" checksum="ACA0B42548805613" modified="2025-10-08" version="1">MSASRSPSSGGTGSRKLVRRVFTNTRERWRQQNVNGAFCELRKLVPTHPPDKKLSKNEILRLAIRYIDLLNNVLDFQQKEEADDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCA4</accession>
    <name>A0ABM0JCA4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trithorax group protein osa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090377.3">
        <property type="nucleotide sequence ID" value="XM_005090320.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848014"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048945">
        <property type="entry name" value="RASSF8/10_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF6">
        <property type="entry name" value="GH01133P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21712">
        <property type="entry name" value="RASSF8-10_RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090377.3"/>
        </source>
    </evidence>
    <sequence length="1152" mass="126161" checksum="D9E8F699EB2A4B3B" modified="2025-10-08" version="1">MELKVWVEGIQRVVCGANYNTTCQDVVLALAHAMGRTGRFTLVEKWRDSERPLTPQECPLRALHHWGEYAAEVRFYLVQAETEKTLTVPAPQMSSSNAHHGGGGGGGGGGGKRAALIQQQQQQQQQQQQHQMRGGGGGGGGGWDRRGGGYEPPGVGSGGDGNSRLVPNNVNSSRQRHYSHGQALSESIKRSSTFSGGHQGSYATLPANLSSSSQHRKHHHHQQQQHQKPPPTGPQSSSYSSSKFRQPALGPLPNGDLSPRSSSNSSSPRSSGASPRVNPAGHSSRAMTGDVREIHPANMPGARPVYPDQIRDREPHRPHQSASRYAHTQPHSGGPHDPGQIPAYPSASHPSQHPPQSYIADPAQPPPYSSLHQPSQPRAPPQSSSSSSLHQRYPPSSQHQPVPSSSHSSAPGPSPHPVPAPRHHMHASPTAAEYENLPAPARNKPSSQQHQQQKQQPPPQYERRNRTQGPSPQWPTAQRLDHQRHPGHVDKNQLHIPTSSHQNDYVYKKNPAHGHNMPSDAQGYPTHNSNFDGTREFPDRYRDEIARGSYAYSDQFGFDRSQMSRSRPVEVSRKVLPRSKSAERPAPVPQQSRGVPQMSSAKGRQAELAESQQLSKSLPSAGFTQLKRSDTGGKLNFVESALMKQQRSSSDSSKSGSGAHVRQHSADGHVRLQNLDSQNWQQQISDSKSGDDSPGTAGLEVSGGSAVLPGVRPSSSNAHGHQYSTAEISKAQPPSSFLSISPSRHNSAFTEVSPRTSRQGSASSPRDDPVAYNLDIQNLDQYTSASSGVSGLLSLPEDGHSRQASLEVEEYDLDQNFPDVFQRENQAGMGGRAHVRPPHSNMPQEYHLDSGNVDSRELHLQQEYLQLVRQVKMQQERIKTQEAQINATNIEIADLEEKEAGQNGNSPSLEVLTSDLSDLERQEAEGQQELEDLERVEWVNVLDGERKREVDLNLQMKKLNEKVGEMDSQLTQLKEEEDKKSKEVEKEKEHVQNEEKKHQEKEKLTALECKKAKGELESLNASVEKKEGQLRKIEEDVSDAENSLKSQESRLSDLEVELRHENMKDFQAHPVLKEPPPVSVADAVQETTAVSSPASVTQSANDGEAILKILEGRLSPRLSPGTADGNGSYNITSAQQTYKSALAAQNPNGVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCL7</accession>
    <name>A0ABM0JCL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein yellow</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101862988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090608.1">
        <property type="nucleotide sequence ID" value="XM_005090551.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862988"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047511863" evidence="4">
        <location>
            <begin position="23"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005090608.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47229" checksum="A2AC0EC44E3E565C" modified="2025-10-08" version="1">MNWTGQLLSLVCLALAYTKVDSRPRLDALMVHEWTSVDIEWPSDAVKQEYIKNGSFVAEKNIITGIKVYKNQIYVTIPRWRTLTGIPVTLATVVQSDVRSKLRPYPDWTSQTVGDCQSLQNVQSMEIDPNSGLMYVLDTGRIGILSDAVKPENLCPAKIVVLDLNTNKQVASYDMPADVVSRDNNFMNDIVLDYVDGQVRYAYITDVLEEVIHVFDFLTGAAWNVKDADSMKAEANGEDFINNGVNYTFTVGVDGIAMSPDFDYVYYCPLAGYKLYQVPTSSLRNGSAQGVRPVGKKVSQSGGVIYSDKSFYYGALADNAVYSWDAQKDARDQNVDIGHVKLTTEMLVAKNNQTMQWQDTFAVDECGWLWFVSNRLQLFITDTMDFSGREINMRIWKVFINETSYLQGARERTAILPIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCR2</accession>
    <name>A0ABM0JCR2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-hexosaminidase</fullName>
            <ecNumber evidence="6">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101863320</name>
        <name evidence="13" type="synonym">LOC101863082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005090699.2">
        <property type="nucleotide sequence ID" value="XM_005090642.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005092391.2">
        <property type="nucleotide sequence ID" value="XM_005092334.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863082"/>
    <dbReference type="GeneID" id="101863320"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021067" description="Beta-hexosaminidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="10">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="182"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005090699.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005092391.2"/>
        </source>
    </evidence>
    <sequence length="537" mass="60822" checksum="BD63727B9CC50684" modified="2025-10-08" version="1">MLSMRCVLLAFICSTSSYALPRTQSGDVNPYRNSGKTKGQPWPMPLSYKPTPTVIPVNDIDFQFVNLGVHCELLTDAYKRYADIIFGSRSRRSLKFKPDRDVAGDSTVSVLQVNAISGCHGGLSIDSDESYTLSISPGKALLTSNETWGAIKGLETFSQLIYQTSSGQYVVNATEVNDRPRFKHRGLLLDTSRHYLRKEYILQNLDAMAQNKFNVFHWHIVDDQSFPYFSQKFPDLSGKGAYNPETHVYTPADITDIVNYAWRRGIRVMVEFDTPGHTLSWGYGQAGLLTKCYKGGKFTGEYGPIDPTLNTTFPFLSQFFAEVAQVFPDHYIFLGGDEVGYDCWQSNPGITAFMKKMGFGDDYTKLEQYYMQKVLDIVSGLKKGYMVWQEVVDLAKVAEDTIVNVWRDKWQDEMARVTGMGYKTLLSNCWYLNYISYGPDWSTYYKCDPQDFPGTAQQKSLVLGGTTTMWGEYVDDTNLISRFWPRAAAVGERLWSDASVTDVGEAQLRIAEHRCRMVKRGFNAEELIGPGYCDVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD53</accession>
    <name>A0ABM0JD53_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 22 member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090964.1">
        <property type="nucleotide sequence ID" value="XM_005090907.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860713"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="113"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005090964.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="61979" checksum="3827405CCCFF352E" modified="2025-10-08" version="1">MSSLKDMRKLKGDEMDLEGLVDHVGSCGKFQVLLVCATFGTLLHIAGGMMFMVFGSYNPGWDCLGEDNTSLSWPTALPTGHPTGQPTGQTTDLPLANTSSQPANWELSSETSLTANASVTESASGAGNGSCDIISRCSAVAFVEGSSTVVTEWGLICDKAWVPSVIISVQMVGVFVGSVLSGAVGDRLGRKVSLYGHISLHTLVHLVIIFSTSWEMYAALNFFIGVAVGGMISTAYVYPVEFVSQWWRGMLGTLPAWNVSSALFSAIVLWLRDWKLVHAVICGVSALTLLPVFWTPESMRWLTVSGSLVRAHAVAKKIAKCNGREVPSVEMMRSVSEQERKKNAHVDTYSYLDLFRGKTLCIFSIKMGIVWLCMSITYFTISFGIKSLSGDFYLNFLLFSLTELPGLLMVAPTTNKLGRRRAGAIHFLTSASACLIVVLMIFFAPNSSSTDLAINILALVAKMVITGAWMVATIFTMEIYPTVVRSLGVGYVNSASRIGAIISPYIVTDSPDLLWLPFLINVVVLVICTLLMLSMPETLGSPLPDTMVHTPVTKRQLLLVEPDTDKRVGAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG46</accession>
    <name>A0ABM0JG46_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lengsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamate-ammonia ligase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101845608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Dodecamer. Interacts with BFSP2 and VIM.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092911.1">
        <property type="nucleotide sequence ID" value="XM_005092854.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845608"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407:SF1">
        <property type="entry name" value="LENGSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="132"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005092911.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50352" checksum="CD40CEE2616E9E47" modified="2025-10-08" version="1">MPLPNKDIKKTDSGNLKPNEKILAPWDGFDYVYIVVYNIHGQALGKFVHVSAMEEIMELGQSVYAGVCFSTIHGVTVVNPNIVKRYKFGSKYMKPDLSTLVPNATPVCRGNNIGHVICDLLHWDGSLDVSSPRTCALLQLDKLLKLGLTLKSGIEFKFTIKGLKSKADMERESRFAATREIGVYQELFLEFMDEMKNMGVIITSVQTDAGPSGFEFTCAPCDGILTADNTSRLRNALEVYLKRKGFEISYLTNFTLESVPVTQHYNFSLWKSDGTNAMAPVDGEKSADYLSDIGRHFLNGLCHHGPALAAFGLPTVHCYRLSRFKACPSYFNYGWNDKTKCVRLRGKEDNTMCEYRLASPQANPYLVFPSIVAAGIDGIIRKLEMPDPVLPVPGDLPSALSALKKDSVIMEAMGEELVNAFVYIKTTHEIEPLMAGETASDEEMLKREMEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGE6</accession>
    <name>A0ABM0JGE6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101854553</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093122.2">
        <property type="nucleotide sequence ID" value="XM_005093065.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854553"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047003230" evidence="2">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005093122.2"/>
        </source>
    </evidence>
    <sequence length="138" mass="14536" checksum="DC00FF65DE52BC11" modified="2025-10-08" version="1">MSSILSLLVLAAVVGCIRADSFCEYTASWDDKTHYEWCAYGCCTEYADVTDDPCCGIYTYPGFIAGVVIGSIVLVVAVVVALLCRRRRLLATTVTYGQSGGPSVISTTATSQQMGIGGGGYGNPGFMASNSSNTVVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHI6</accession>
    <name>A0ABM0JHI6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Uncharacterized protein LOC101862711</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101862711</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093781.1">
        <property type="nucleotide sequence ID" value="XM_005093724.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093782.1">
        <property type="nucleotide sequence ID" value="XM_005093725.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862711"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08698">
        <property type="entry name" value="TGF_beta_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF309">
        <property type="entry name" value="INHIBIN BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021083" evidence="8">
        <location>
            <begin position="41"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="379"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005093781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093782.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="67094" checksum="9560B27B0AA3AC4F" modified="2025-10-08" version="1">MYGPGIRMDRVNFVRTLSSCSTVGLILVLLSTTVPPTVDCNGTISSAMLNQTIREKIRAQRLLEQIKHKLNTSTPSDISVISGIPRRLHSRPQHQSSSTKFNLNNANILYPGTDAQTRYNQSWPLVNPKPPTKTVLRPAMPWNSIIPAVGVDRNILAFSLKNETVSGTRMVTKIYLWLYVWKRERKKKMTSSSRPITSSASSSGPSARDMAAKRRGARNKRQKKGKMIKIRVFLSDENGKRGQRIAQLKKKVHKSKWETLGLPVSLVKSIESSSRGNKLWLKVECKRCTRRTQLVFPTTSDSKKCRRNKRKKRKGRTRKSSKDKKSMRRLRKKCASEVADSKMFPFIVLEEKPMSANSRPKRDVEKENAPVFPFRPRFRGKREKERFGSQPEKNTRAEMQAHIVNQEQTCCREQKVFIEFSDLNLDDVIVAPSGFTLTTCTGSCFGDVTSTSTNNVHSLCSGKHPQNEMLSNTASDGQMVTSFPAQHKTLSADDNSTNTSHTSQKIRQHVRNFLETEDPNVRRGPHSFLSIVASRKRRRLKLKEPPPQCGPVERQSLVIVHFTQDNNLVQSELPNFLISKCGCKGNLLPNKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHW5</accession>
    <name>A0ABM0JHW5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Iodothyronine deiodinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iodothyronine deiodinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094017.1">
        <property type="nucleotide sequence ID" value="XM_005093960.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857630"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000643">
        <property type="entry name" value="Iodothyronine_deiodinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781">
        <property type="entry name" value="IODOTHYRONINE DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781:SF22">
        <property type="entry name" value="TYPE I IODOTHYRONINE DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00837">
        <property type="entry name" value="T4_deiodinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="1" id="KW-0893">Thyroid hormones biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094017.1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10335" checksum="7E217697064C9986" modified="2025-10-08" version="1">MEAHASDGFWPNEAHSIKAHTALEDRLESAKTLDDIGISGRLLVDSMEDLASHLYGAVPERLFIVERGVVTYVGALGPVGYDLDEVEERLKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHY7</accession>
    <name>A0ABM0JHY7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein disulfide-isomerase A5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101863732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094049.1">
        <property type="nucleotide sequence ID" value="XM_005093992.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863732"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02997">
        <property type="entry name" value="PDI_a_PDIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046374">
        <property type="entry name" value="PDI_a_PDIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF2">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045901071" evidence="3">
        <location>
            <begin position="29"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="138"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="259"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="386"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="532"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="660"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005094049.1"/>
        </source>
    </evidence>
    <sequence length="800" mass="90249" checksum="CF12D3FDDCEEA716" modified="2025-10-08" version="1">MAAPMEKTILVFISIFVLLLMVPYYSHAQNKKNHKSLIIRVEDFKEFKKLLRTKTNLLVICAESEKATAKVMKLFDEVAQEMKGKATLAYVNCGEDKKFCKKLKFSPTAYDLRHYKDGEFNKEYDRKLAVKSMVNFLLDPTGDLPWEEDPTANDVVHISSEEGFNKLLKKTKNPILVMFYAPWCGFCKRLKPDYSGAATELKNKYTLVGVDVDKPPMMSLRMQYNITGFPTLIYFEKGKVKYKYGGENNKAGIVSWMKDPQPPKEPEKEAEWADEKSEVVHLTDSSFEEFVKQNPSVLVMFYAPWCGHCKKMKPGYTEAAQQLKDEGITGILAAVDATKEKKIAQDNGVKGFPTVRYFKDGEYAFEVNERDKDKIIEFMKDPKEPPPPPPPEPKWEEVESEVVHLTDDSFKGFLKKKKHCLIMFYAPWCGHCKKAKPEFMSAAEKFKEDTKVAFAAVDCTSQTGSCSSNDVTGYPTFKYFNYGKNSQKYMGGRNENDFVAFMNDPLNPAPTPAPPAVQSMDEQWRDFAGYESLALLSASNFELVVAESSQLLVMFYAPWCGHCKKMKPAYAEAAAIVEREGLGTLGAVDVTVDGDLGSQYNVKGFPTLKFFKNGQVTDYNSGRSQELLVKFMRSQASVASEKVEDEEDAAEALDMAPKQRGIEEPRPSAFVPSRSVQGLVQANFSQYLNDKQAALVMFYDPDCQYCNQAKPHFMKVAKTLQNKQRGFGSVDCTQEKGLCELEKVTGYPTFKLYVGGKFLSRFAETPNAQTMIRFVENAPVAVEPTPDEKPSGSRRSKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIM8</accession>
    <name>A0ABM0JIM8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101847943</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094508.1">
        <property type="nucleotide sequence ID" value="XM_005094451.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847943"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005094508.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40811" checksum="C44345DA78F43AA7" modified="2025-10-08" version="1">MAVSKVSIPGGMFESQEQEDEVQRSICNRQDEAERRQIREGYRNFMDDLTEKKNELIDPTDGNDLLSQKLSAVDNMFQKVKMTREGALDSASLVTLADYGKMKAQALKTDFITFNPADFCEKVKLTVAGDAESAVRGDLTPAQWTSLGQTVQSFFKRAPVLQFMCGSFERGEVIPRVARTKEREKVQDNSVIKATKPTQLSSLEETDRGELTTAQVDHLLNTLWSIYESQDHTPICFFEFVTNPHSFGQTVENIFYASFLIRDGLAKVTLDDDSLPVIEPIQKEDIENERSETAERHQVVLSITHEEWKEIVETFKIEEPLIKPCDILKDRQQLANIPEQRTVTSAKSKGKGKGKKSVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIX1</accession>
    <name>A0ABM0JIX1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fermitin family homolog 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094708.2">
        <property type="nucleotide sequence ID" value="XM_005094651.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853377"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17095">
        <property type="entry name" value="FERM_F0_kindlins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17096">
        <property type="entry name" value="FERM_F1_kindlins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037843">
        <property type="entry name" value="Kindlin/fermitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040790">
        <property type="entry name" value="Kindlin_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160:SF13">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18124">
        <property type="entry name" value="Kindlin_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 4.1" evidence="3">
        <location>
            <begin position="89"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="399"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094708.2"/>
        </source>
    </evidence>
    <sequence length="712" mass="81264" checksum="93BE91264E969CBD" modified="2025-10-08" version="1">MAYVADGTRVDGSWELNILVTDLQVERTLRVMGDLHIGGVMVKLVQELDIALDWSDHALWWPEKNKWLLRARSTLDQYNVQADARLQFTPMHKNLKVQLPDLQVLELRVDFSIKCFATVVQTCKELGMRHPEELSFLRKWDRDDLKKVAKEVHKRKKRGDPDQNGPLTANGTHHNSSGSLDGGKLSPYPSRSPIGPSPTSTLVRSANSPHNLSTSISGYSTFNGTLSPGSMHSLSFEGFMESTLANSPPVPAKEAFQYLYRPRNFQEKARINCAWLDSSTSLMEQGIRENDFIMLKFKFYNFYDLNPKYDAIRINQVYEQAKWALIAEEIDCTEEEMMVFAALQFQVQLQSGLPQPDLDQSQGTNNHSEDDEIDAALKDLQESLEGSAVSSHGDITHIPELCDYLRFLKPRKLTLKSYKRYYSTFKDTFISFYRSKEEAAGPPVMARIDVRGCEAQPDVNLSARKYGIKLFVPEPEGMSEICLRFDMEEQYCKWMAACKLASKGKTMADSSYEAEVQALQSFLGMQHPVVSPGSNTTSFSTTPNQADIQPEDYVASRFFKKIKSKSLIQRIMEAHSSVQEMNLMEAKLAYIKAWQSLPEYGITYFRIKMSNGKKEELMGIAQNRIIRMDLNSGDSLKTWRYSTLQSWHVNWEVENVILDFEQDKVTFASMECSCKTLHEFIGGYIFLSMRSSEKNQSLNEEMFHKLTGGWHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ06</accession>
    <name>A0ABM0JJ06_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clusterin-associated protein 1 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Clusterin-associated protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101847322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLUAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094767.1">
        <property type="nucleotide sequence ID" value="XM_005094710.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012935932.1">
        <property type="nucleotide sequence ID" value="XM_013080478.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847322"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019366">
        <property type="entry name" value="Clusterin-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547">
        <property type="entry name" value="CLUSTERIN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547:SF0">
        <property type="entry name" value="CLUSTERIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10234">
        <property type="entry name" value="Cluap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005094767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012935932.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47847" checksum="B215CD472A09C417" modified="2025-10-08" version="1">MSFKDLRNFTEMMRALGFPRLISMENFRTPNFKLVYECLKWLMKRYDPNADVHPDIDTEQDRVIFIKTVAEFMATKAHIKLNTKKLYGADGYAVKEMLKITSMLYSATKTNVAGSLEAGAGDASSVSFDVSSRINELKEARRLASEITVKGAQLYDLLGKEVDLREQRTMVVARALEINEVEHGLQASIEAVQNEIQKTVTMLDNVASDEANLEAKIEKRKSELERNNKRLQTLQSVRPAYMDEYERLEEDLQKLYDSYMIKFRNLAFLETQLEEQNRVEADKLEETEQQLKVMAEKIRTEERKHQQISPEDDDDKNIIDDDDENDSDDMGAPNRMSNRVRPEAAGQQRGGNRVTGTMNPDISEDSGSEGSGDSDIDLDDDDDDDDDDDDIQGMGQGMGQGIPQPRGRNQPPQDDLDDSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK44</accession>
    <name>A0ABM0JK44_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101853229</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neurochondrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095573.1">
        <property type="nucleotide sequence ID" value="XM_005095516.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853229"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095573.1"/>
        </source>
    </evidence>
    <sequence length="951" mass="105212" checksum="3C76613A90F899FC" modified="2025-10-08" version="1">MYAAHAEQKRKESSQIVLEDCMSILQSAKSDNDKFMAVVEIAECVHSNSFTDADRVKILQAMGCDFLARLIRTTSVPSGCPGDLYKSMALSVLSVVSVEPSMAVLPEMKEILPEVNGVISSSMNERKSDDKSRDSLQIQMCEDCIDFISHFAQHEKGIDLLTQGGTVPLLLDLVESPVCQKKVSVLSSLSSVVKSRGDGVFLGKSEKFHSIMSLAVDSLVQTNDLREKSSYAKIITSLLSGMSLMEADESVAWVVKITQCVKKLMVLKLNPEQSEILLLLACALVSAVGAGVLRADVTGDSTLLRTVVARLSVETYMLLDGISLENAMERYPTMDKVYKLICDVVQFVAENDEDSADTDSIIAVYRKLVDISQTLMEFLFSVANQEVELPRNHVVVLLSVRTLAAMLTEITEDPTPQLLELLPFFNLLCQNVDYSDDVKMEVKNATQAALANIKMMGMNVINEVLEEVEEEEEEERDGGKEEAEKTRAEAMVSSGEKKSSSRTASEKKSKCENSGDASHSGGSAFDSLDVKDGFKQLSLSHSSEKQENSESVNVKPTTDHSHHLLNGDVECDVNDDPGHNSGDGSQKETSGQRKKKRSQQVVNVELDAECLEKFNVYRETLRAAKLKPALLNQRQLSFIGKAKKKRGSEENSEVSPHWHPNADDVLGFLLPTYAFLLEHEEVLQIMVKCDAFQTVVNFIEKSLSQFLESKSTVFPESTTRNALGVLEQVYSNAPATAARLDCFQNLFEISVLSVPNLVGLSHPPALVCLKLIEVTLVAYRLQMRGQKRNSSLSRLKHSQSRFFRAVVEYLASFYAIRQSRRQQALVLQIVRESRDMWPLIEDAWCGTVAGLCTLIRDVEDLQDAFVKSLMIPEFLTFLAESDGDADLHSYPEGIQRLMESLLSLVESAAEGSDILCEMLLHHHGRKVASKFGLQKLARCLQSKVSAGSKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKA8</accession>
    <name>A0ABM0JKA8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Proton-coupled zinc antiporter SLC30A5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 30 member 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Zinc transporter 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 26" type="primary">LOC101846419</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterodimer with SLC30A6/ZNT6; form a functional zinc ion transmembrane transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">COPII-coated vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Secretory vesicle membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095708.1">
        <property type="nucleotide sequence ID" value="XM_005095651.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095709.1">
        <property type="nucleotide sequence ID" value="XM_005095652.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846419"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF1">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0050">Antiport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="23">
        <location>
            <begin position="412"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="539"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="539"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_005095708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_005095709.1"/>
        </source>
    </evidence>
    <sequence length="787" mass="85869" checksum="CC1F56D0FB1118CA" modified="2025-10-08" version="1">MVQRFSNGLPSRSIHPPSGLTVYIVLLVISKFLKAVGLYIAYDLLKVIPVVVFLFFLKAGTSVPLVLLQKPFTNGPRLSKHQWFRIWRHALFGSGISYLWMFGLTQCGPLRSIVLFENTDIVILAGASALFSSNGGGGPSKARGAIFFLVGVLALLVFDHDEKLNVLGDQDGETIHHHTIFHHFFKHGIDFLGWSDHKGGVLLLFFTLCLNCGYNSAAKKLSVEVGGAKRLHSLSTVVSTAFLWPWACFIFFTMETEVQSWFSVFFPLTLVILFVGVFDFYIDGLATSHLQPLKAAFLAPLAIFSAAIFLSLTWTHPYVTRVTTMHKLNDIVTEDHVLSAGVIFSVSAFLLATRMLMARDRAAKGSFIGYNPAGLPLYSISSEALQKTSQSVLSVLRNGLRQILDDGDSRKIFYFLCINLGFTFVELLYGVWTNSLGLISDGFHMLFDCSALVMGLYASIMVRWKATRIFSYGYDRVEVLSGFINGLFLVVISFFVFSEAFGRLFEPPEVKTEKLLTVSVLGLLVNLVGIFAFQGHGHSHGGGHGHSHGGGHGHSHGGGHGHSHGGGHSHGGGHGHSHGGGHGHSHGTSSSEPASSSGGSHSHAHHNTNMEGVFLHVVADTMGSVGVIISTLLIEHFGWNIADPICSLFIAALIFLSVIPLLRETAVILLLRSPQQIESSLSSALDKILTIEGVLSYREPHYWSHTASKVHGMVHLQVWPQAQEQRIIAQATSIFKEAGVSNMTVQVEKQSYFFHLSGLGASPVNIAQFAQQPHLRSVDDPLSVKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKN8</accession>
    <name>A0ABM0JKN8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADP-sugar pyrophosphatase isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101864609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095948.1">
        <property type="nucleotide sequence ID" value="XM_005095891.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864609"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047393756" evidence="3">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="115"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005095948.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="28995" checksum="605212844308291B" modified="2025-10-08" version="1">MQRNLWTLSLLIGSKHWLPVFLIQKCFWSHQILTKLRLKHRVSLFGNSLCCPGSERRTTMASKNSAPTKGKSEHISTKEVARGKWVVLNNVTYKDPTGKERSWEAIGRTTKCKGEADAVGVIAAFNDPSRKCRCVILVRQYRPPLKAYTIEFPAGLIDAGETAAQAAVREMKEETGYSVSVSKVLPASALDGGVGETTMKIVICDLDVEAEGNKNPAAVGGGADEFVDVLIQPLPSLLEKLNEYSEAGDVVDSRVYAWAVGRQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKS7</accession>
    <name>A0ABM0JKS7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Uncharacterized protein LOC101846067</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101846067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005096037.1">
        <property type="nucleotide sequence ID" value="XM_005095980.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936613.1">
        <property type="nucleotide sequence ID" value="XM_013081159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846067"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="ARCHAEMETZINCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910:SF1">
        <property type="entry name" value="ARCHAEMETZINCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005096037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012936613.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="50177" checksum="95364751D50E2E02" modified="2025-10-08" version="1">MGALHSTVTGEEQDFRPRNESTVGANGQSNTRGHYVFQMPKRTHETTRKDFEYLIGKLEHLPASTQKLFSLGKLYLRAGLCQDVRGDGDQTVRPVEEQTVPGITHTYRLGLEAEGASGDETSQISTQVEENSLSRHERYSSDSTRPNESDLGLFTPFVMSTPLYHMQTFTRWKVAYSLNNLYPFCYRKRRTTIYIQPLEDFPDFFSSYRVQVGKLTLDFFQLLQSFVQIYFSGFESLVLSPVSLSSMDGQVRSREHEVTSQKQYCVNDLHPLMQQLLPPDGLSVVGILWTDIYPEGYNFVLGEASATHRSAVISFGRFETKGYDLATHQDISEVNGALLWKLFKTLSHETCHLLGLDHCQFFHCAMNESGSVSEAMEQPLFLCPVCLRKLQQASQFDLLERYQQLRQFLSAVFAQHDDSDRLRLSLDWLNSCIHYMTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKV5</accession>
    <name>A0ABM0JKV5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101858482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005096092.1">
        <property type="nucleotide sequence ID" value="XM_005096035.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858482"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF126">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005096092.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32435" checksum="1AD381265B57AC00" modified="2025-10-08" version="1">MSGGNYTVGRLTPLPSEPIWLCPLGFVNDAFFSIRDPRVRQFPMMSWVTPNCIVICAYLAIVYFGPKLMAPYKGFSLKWPLVIYNFFMVGVSFYILFEHVHTAYLSNYTLLCQPVDFSTNPLAMRMARAVWLYFFTRYVEFVDTAKNTIKRGLTYNAAINCFIHVVMYTYYGLSALGPSVQKYLWWKVHLTKLQLLQFVCMLILMSCNTTCNDPNFPQFLNYIGILYCSTILGLFLNFYIQTYFLKKPQKKASSVQSNGTLANNGSSGTHKSESNGIKKHHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMM1</accession>
    <name>A0ABM0JMM1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Forkhead box protein A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005097243.2">
        <property type="nucleotide sequence ID" value="XM_005097186.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848042"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20041">
        <property type="entry name" value="FH_dFKH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047388">
        <property type="entry name" value="FH-like_dFKH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013638">
        <property type="entry name" value="Fork-head_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF380">
        <property type="entry name" value="PROTEIN FORK HEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08430">
        <property type="entry name" value="Forkhead_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="146"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="146"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005097243.2"/>
        </source>
    </evidence>
    <sequence length="528" mass="57900" checksum="BE76EDE713E100F9" modified="2025-10-08" version="1">MLTSKPPHYDPVASGIGSGIASGGYATSGMNTMGPSMSPMPSAMSAIGGGMSYSPQAMGGMAAMGSMGSMGAMGGMGSMSAMGGYGSMSAMNTMGGMNGMSAMGGMSSMNGMNRPLDANLMSMDRNGALNRPRTDKNYRRAYTHAKPPYSYISLITMAIQQSQNKMCTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKVPRTPDRPGKGSYWALHPDSGNMFENGCYLRRQKRFKCPKKEMIRQSSHRSQDDDGSLNPDDSMHSGDEHSPMSSPIPGVPSQHGPSQPPPRTSPRPHDHHQQQSQHPHAQQQQQQQHAQQQQQQQQQQQQQQQQQQQQQQSQSSGGGSIQPKTEVMNNSSPHPQELAHPPPAQSLPPQVSCHTPLSSQPSLPSYHHNSPAAELSNVRSLNAQDYGSQLTSQSLGLHYPAGHYAPHPHHHHHHHQQAGLHQLGPNHSFNHPFSINNLMSESKLDMKSMYDMGYGAYAQMSPLTMGKDPSPPVMAAHHDAGGYYKAYQSTVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN03</accession>
    <name>A0ABM0JN03_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101847035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101847035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097498.1">
        <property type="nucleotide sequence ID" value="XM_005097441.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937443.1">
        <property type="nucleotide sequence ID" value="XM_013081989.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847035"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005097498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937443.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22873" checksum="992DD4C7F093002F" modified="2025-10-08" version="1">MAIPLNAVQTDVDRLIDLFLSPDFNPETIDLSSYGTDEGFGYEAEAGEEVADGELEGGDWRHDEFFLKRCGRTLSKLGDEFQRSRPAAQAGPATSSPIDQMKEALEKAVQASETEGSNTQPSKETKERAWAIFKGVMENAVSDTVFKDAYQELGAFLMAIRGVRLMGEGVRDLARDLSLRYIRDRQLDQSIQRMGGMEALMAHELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNV8</accession>
    <name>A0ABM0JNV8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Guanyl-specific ribonuclease pgl-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101861438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098076.1">
        <property type="nucleotide sequence ID" value="XM_005098019.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098077.1">
        <property type="nucleotide sequence ID" value="XM_005098020.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861438"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098077.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="38365" checksum="6F01F25AF2C80F78" modified="2025-10-08" version="1">MIPRNTLTKLTYVDTASSNLIDVSNSAVGTRRACKPQSFTLRRKFRAQHGTESDQERDPQTMPQRFNRPNTKPREQSQLAQGAPQKEHFDQKSHLDYGRMRRSQSTDRCQSVTAGEGPMSSDNVSTQPPLPGFRPVENEGGDNNMADTDRNQSGQANADDSEGGSPEGRLTDEDGEAEEECCYNFPDSLLSTGSVGWFIVCIILLTMVVSIAVTITDKSLCFYPLPVYLKGWGGGTGAGAGDSEIAGDGCGGYGDDNRAGCFGDSGDAKRTDGYGGNGDDDGYSGSAGGRQGLGGSADGYNYKDRGGSTGGYRGHGRSAGGAGNGGPFGYDYDTRPDKTHGWRSQRPWQTRKAPKCRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQR8</accession>
    <name>A0ABM0JQR8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 4E type 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101856101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099335.1">
        <property type="nucleotide sequence ID" value="XM_005099278.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856101"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005099335.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25873" checksum="59C181411AEDFA8E" modified="2025-10-08" version="1">MAAASVDKQIEGHGEPCRKEDFIDSADRMSEAIAKETKDIPLEPLNTPWTFWIDRSVRGTTAREYESSLTKIYTVDTVQGFWSVYNHIPEPDKLSIRFSYHLMRNNRRPVWEDEENSDGGNWTFKCKKNDTDDVWKHLLLAAIGEQLSDCMADDDDVIGISVSIRDRDDLILIWNKEARLKESSTIVQKVRELLPHVTFNTVFYKAFNMHDAFEGKKGYHNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRB2</accession>
    <name>A0ABM0JRB2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-alpha-acetyltransferase 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101845550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099712.1">
        <property type="nucleotide sequence ID" value="XM_005099655.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845550"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="254"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005099712.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="43846" checksum="23432835FDDA0163" modified="2025-10-08" version="1">MTDKVPVPIASSAASVSQCSTCCSSTTPSRPVAAFVVPTSVPNPPSVSKGSTIQSPLNIQCSIVKSNDEETSCSDCVLENGSSAAPHHPGLDPVLVRSEQDSGDGTTDSEGGLGPTDGSTNSNSCCEISDKAKCSERLNGLTHATHIIGDNGISKHLLNECSSSDNVDNTQEGRSHSCSQSQNYESINVLDRESKDVEVSCDKGVKATVGLSTEETSACVNRDEVDDLLGQLEKTSLDGDQHTVSSNSIINGITYIVYGSERQMPDIMRLITKDLSEPYSIYTYRYFIHNWPKLCFLAVADNKCVGAIVCKLDLHKKMVRRGYIAMLAVDSEYRRRQIGSTLVTKAIQAMIRDDCDEVVLETEITNQGALHLYENLGFVRDKRLFRYYLNGVDALRLKLWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRL7</accession>
    <name>A0ABM0JRL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 234 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099930.1">
        <property type="nucleotide sequence ID" value="XM_005099873.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858497"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005099930.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15625" checksum="D6E4D56E46CBE6E6" modified="2025-10-08" version="1">MMSGLASAAWLTTVAFLWGATNPLLKRNSKGVEKIQKNGKISQFIAEFKFLFLNWKYLLSFLLNQSGSVVYYITLASADLTLAVPITNSLTFIFTALSSQVLGEKNLNWETLCGMVLVVAGVLLCVLSKTELEEQTSHTAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JT49</accession>
    <name>A0ABM0JT49_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IQ domain-containing protein K isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100888.1">
        <property type="nucleotide sequence ID" value="XM_005100831.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860822"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22969">
        <property type="entry name" value="DD_IQCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043408">
        <property type="entry name" value="IQCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34927">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34927:SF1">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100888.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33849" checksum="A5254A49182E7E5D" modified="2025-10-08" version="1">MSVITKVPEPNLWEEICKEFTHQKPPFTPDDDAASVTTDYSDYDPSRHNPVFYGKMFAPVRTDEDATGEFDAADSHPSCVGFTFTEKPPKAASPPPPLPPNKNTCTPTEYLNHYVFPWLLPALEAMLKQAKLEKCFEEEPLTDEDKRRRTKFNACDFITEHLYRHNPNSKSDGRADIELWDIPFVKEWLKDHPRPPLPMSLIWTDEEAALIIQSFWRGYLVRRDPEVQELRCWQREWREENRGIQHRVSEFWEKQMPDGDQPTPNASEQQIDQLKPEEPSVVIKSPVPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTJ9</accession>
    <name>A0ABM0JTJ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein brambleberry</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101846432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101161.1">
        <property type="nucleotide sequence ID" value="XM_005101104.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846432"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040346">
        <property type="entry name" value="GEX1/Brambleberry"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538:SF1">
        <property type="entry name" value="PROTEIN BRAMBLEBERRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538">
        <property type="entry name" value="PROTEIN GAMETE EXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045826170" evidence="4">
        <location>
            <begin position="25"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005101161.1"/>
        </source>
    </evidence>
    <sequence length="630" mass="69941" checksum="EFE43A298738B8C1" modified="2025-10-08" version="1">MNLKHHCVHAFLLFTIIFCQPSSSVFEWLFGAGEGGEKAAGTLGGENRTPIRFEVLSSDEKFLDFAQTLTDLSPLDACYNIVIYSLKTKCGELSEEELGKLSVQLLNCQSEVEDRTVFPCTASMSLADCTKSMDGTTWNSYQIVGNRARAMCYATQQVQFRRLTEQTVNRLLGATSEQVKSLNELKDGQDQLHSLTAETVRKLYESQQDLLSTQHSLRDAHQDIFNHIASNVKEIMQEKALIASGNRELASMTENIREKLELTAEQIKQRESSEHKKHERILKDLKDIQDNTEASVRKLDNNLQRLLGKYEELDSQYGGLAENLSKMNGTITYLMASVTYMQKHLDDRINWISQLLDGADDKLSAMSCCLLHIAYFFLLAVTATFLQVSLPVRLAMMVVIVGNVAAELNYDHSLDFAGLTVFLCTLYFGFKLVVYSGRRFDRTRRYFSHSQGGTPQRGSATGSPLSSDEMRTLLDLLQRFSRGVSGHLNASYAPTANGTALRDTSIGPSRHNVGPSRHDDRHSDGHSDSGDEPVTPPATYASFLNSSSRLLDASRTELPTPPRRTVLDPLITGRGSRSSSRASTPVPRDSRSSTPSVSSRCLSNTVAGTQCRMPAAGGSDFCRRHSQSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV51</accession>
    <name>A0ABM0JV51_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101860028</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102241.1">
        <property type="nucleotide sequence ID" value="XM_005102184.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860028"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102241.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11688" checksum="6F6143A48E9B002F" modified="2025-10-08" version="1">MSENGTGRPLISVLKSRPEDEDPQKPRQRKEEKVRFNDEVSYAPSVGGSAENTRSFFSIRENSSEPFQSKLRRDSFGNVNEQMQLENKRRWCCRCGCLCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV55</accession>
    <name>A0ABM0JV55_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101861297</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102246.1">
        <property type="nucleotide sequence ID" value="XM_005102189.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861297"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="12"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005102246.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="37408" checksum="AD6C406C1CA74BF9" modified="2025-10-08" version="1">MADINLTAMLYKTDDLRMEDLPVPKPGPGQVQLSMQEVGICGSDVHYWTHGRIGDFIVKAPMVLGHEASGIVSELGQGVTSLKVGDRVAIEPGVPCRMCNYCKTGRYNLCLDMKFCATPPYHGNLARYYVHDADFCFKLPDHVSLEEGALLEPLSVGVHATNRAGVGLGSTVLICGAGPIGLVNILTAKAKGASVVCVTDIDESRLQKAKELGADYTVKVTSRDAQQTAQLVEEAMGEKPDITIECSGAPSSLQTAIYATKSGGVVVLVGLGQEHVEMPVVNAGVREVDIRGIFRYVNCYPTALAMVASGKVNVKPLITHKFKLEESIKAFEAAKRGEGIKIMITCTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVV2</accession>
    <name>A0ABM0JVV2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Gametogenetin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101864311</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102714.1">
        <property type="nucleotide sequence ID" value="XM_005102657.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005102716.1">
        <property type="nucleotide sequence ID" value="XM_005102659.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826777.1">
        <property type="nucleotide sequence ID" value="XM_035970884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864311"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026073">
        <property type="entry name" value="GGNBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13601">
        <property type="entry name" value="GAMETOGENETIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13601:SF2">
        <property type="entry name" value="GAMETOGENETIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005102716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826777.1"/>
        </source>
    </evidence>
    <sequence length="608" mass="69268" checksum="1B691288C10B38E0" modified="2025-10-08" version="1">MARLVSVCESDEEFEFQRRQVPLEVDNLKMVVQFSDKCVDCEKLCGVKQKDLEIFINKFNSLSKDEVAIALLVSGKDIMSLLSHMVPCVGCRKSVERLFVQLQKSQHPALEPLVITPRGEMSVRHEYLFDPRSLFSLFHVHGSKLHSVVESIPKSKKNKRCNLHSLETHKSKTLGCWLEAWDALSDSCREKVLVVDMNRLLTSVESYLEKHKFCTECKSKVLLAYSILVGDHDSSVEKGYCAALYENLRCCAKERHVHVLNDTEFIAHLLEKAEPEFLGGKRDRHAKTLDIAQEEVLTCLGIHIFERLHHIWQKLRSEEQTWLILFYIGVDALRKSYQVALEEKQGASNLELLCEELEEKEKRQEEKKELKRLKRRQKKAKAQTQICNSVNNNSCSNGVGLEEIPCKCLSVDNDNAEKNNNFHQHLRGNRESCGDANFNSLTLSFQSCDLSLKNCQGCLDGGSSSSRQNRRDRWTDEDSCESCSMQGSNEGSEEGECSGSFTDSVDSCDCDMLRNSPKRTRGQQGSFGCNGSQCNKYPFQAGEQPSLQDLLEELCWDDGGDEDQGISEEEILAFKAKQGEVESKRQKLRQNLRQRFAEFHLSRHVNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXN1</accession>
    <name>A0ABM0JXN1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101858652</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101858652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005103952.1">
        <property type="nucleotide sequence ID" value="XM_005103895.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858652"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="53"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005103952.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41663" checksum="D2F47D22CFD1E5FF" modified="2025-10-08" version="1">MSCGDGATVRNLTEGTTKCPGKSGFMNDDVTYTVRFYLDFVVQMSIVIFGISSNIVNIVIFVKTGLEDSVTISFLALAISDLGFSVFFLLMRIFGILSNVYKLGPTVSMGTISYLLFWYMNLFFDISVLVTTFTAVEKCCCVAIPLLFKNVFTRFRTVITLVVIYLAVLVTYIPTFSSHGLKLKFDPVRNHSRYVYANRSYTMLVFDIYTVFNRMVIPFVSQVAVLFCMVVLTIKLQVATKKRREMTSEQSCEVNESNDRKNKEKVLGKGKNRLSRKEWRVVQAVNLVAGIFVASNLPEIVISFCALYYPEFSDFGRYKNLYRVVTSLQDLITVTSAAVNIFVYLGYNSKYRQEFLRSIGPTEIDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYY0</accession>
    <name>A0ABM0JYY0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransferase 1C4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104814.2">
        <property type="nucleotide sequence ID" value="XM_005104757.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857894"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="93"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005104814.2"/>
        </source>
    </evidence>
    <sequence length="192" mass="21785" checksum="6AE05E7FB2F73EC9" modified="2025-10-08" version="1">MPVFRISINVKYVHVFLGTTWMQEITWLLMNDGNISAAKQTPVYMRSPFLEFKDMTLNEVGLDIASQMASPRVIKSHLPLKLMPSLLHKSGPKDPLAEIKQLAQFLGKTNLDDVTLSSIANHCSFQEMKSNPMTNHLDVYSIDSSVSPLLRKGTVGDWKSQFTVQQDEDFDKVYSHKMAGFDIPFLYDLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2Y4</accession>
    <name>A0ABM0K2Y4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-methionine-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101854198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005107542.1">
        <property type="nucleotide sequence ID" value="XM_005107485.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854198"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050162">
        <property type="entry name" value="MsrA_MetSO_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799:SF2">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047124171" description="peptide-methionine (S)-S-oxide reductase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="9">
        <location>
            <begin position="75"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005107542.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27465" checksum="948F495A8DDDA01A" modified="2025-10-08" version="1">MTSWMSRIARLLVISNILRTQSSGFWSMGEMASKTAMVSKDDALPGRSEKLKVSPKHTVLGTTTVPPFPENVENAMFGLGCFWGAERKFWNQKGVFSTQVGYSGGFTTNPTYKEVCTGQTGHNEVVRVQFDPKKISYVDLLQVFWENHNPTQGYRQGNDVGTQYRSAIYTYGADQQSQAEESKGNFQQALTKEGFGAITTEIQPAGEFYYAEDYHQQYLDKNKDGYCGLGGIGVACPRGLVKAKQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K386</accession>
    <name>A0ABM0K386_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107737.1">
        <property type="nucleotide sequence ID" value="XM_005107680.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857826"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005107737.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13647" checksum="DB8ABD09DCED0663" modified="2025-10-08" version="1">MGRIFLQHIGGSRLFTCGSCNVALTNRAELISTRFTGATGRAFLFNRVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNAKLGWIYEFATEDNQRYKEGRVILERALVHEVDGMDEQVVNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3G8</accession>
    <name>A0ABM0K3G8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger MYND domain-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107885.1">
        <property type="nucleotide sequence ID" value="XM_005107828.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853582"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053248">
        <property type="entry name" value="Zinc_finger_MYND_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005107885.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41904" checksum="6D70AC0CC17AF6DB" modified="2025-10-08" version="1">MDINPLANPKGVKLLCELCQIPAFLQCKFCNVTYYCSLEHQKADWIGIHEKICDRLAFLRQPVPFLASREDRERRQKEVQVKKIELIEMTRTLAQKMLFEGKHEEAVPAAMQSLRYSIEVYGVSTIELVPSYLILGEASVGLGKLTQAEEYLAKADWTVLKTPDCSRAIQSKLYRNLGLLYAAKGDFPEALNNFADDIYHASEEFGTDDIRTAGGYFHMGNVFFRQGKMDVADSLYRQVINIWYSHLADVLKSNTPSEEELAQSRTRILGPVKGMFEEMGSGLDEAQEAEAVQILNSIHDIREHQTTRLPQDLAQACHALAMLYFVLGDIKKAKEYGRKAIVASDQVKDDDFSQSLVEFMKLCERQGTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3P3</accession>
    <name>A0ABM0K3P3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Synaptic vesicle 2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101847141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108026.1">
        <property type="nucleotide sequence ID" value="XM_005107969.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847141"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="98"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108026.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="60045" checksum="9CBF29C6CB083277" modified="2025-10-08" version="1">MAAAMFTRLTRLGKGDDYEDLDGGDDNVEMDITDMYRSLGKNPPSGPAKAEAGKEDGNKLKQRSVDSGPPATTDGAGETFTVQEAIDQIGFGKFQVKLSVLTGFAWMADAMEMMILAILSPALHCEWRLEGWQEAFITTVVFCGMMFSSSLWGSICDKYGRKTELILCSLITCYFGLLSSFAPSFIWMLILRGLVGFGIGGAPQAVTLYAEFLPTKSRATCVTLVETFWAIGACFEVLLALVVMPTLGWPYLLAFSAMPLLFFAIFCVWLPESARYDMTRGCYDKALETLERIARENGKPMPLGRLVDPAGPGVKRGQIKDLFIPELRLTTVLLWIIWLVCAFSYYGIVLLTTALFENPDGCHGTDVKFNPNPSCFLECKTLTTADYKDLTWTTFAEFPGLFITAYLLNKIGRKLTMAVEFVIFTIFVMLVNICTTRALLTFFLFVARAFISGAFQGAYVYTPEVYPTSMRALGLGTCSGMARVGAIVTPFVAQVLLKESAYTAISIYGIMCLIATVASFCLPIETKGLDMKDMGSEVAKPKKTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3X7</accession>
    <name>A0ABM0K3X7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Krueppel-like factor 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101864330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108180.1">
        <property type="nucleotide sequence ID" value="XM_005108123.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864330"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF164">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="576"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005108180.1"/>
        </source>
    </evidence>
    <sequence length="672" mass="73150" checksum="42E5F33B79BEA8CA" modified="2025-10-08" version="1">MKSSVPCHGVERDVAESLLFMANVLPDREENNKGNQIPPAPPLRKQSTLEQLLKGKNPSNYNFVMGSGAAFQSQSVPVIVPRPSPSSKSATASAASPTKLEVDVSPKSASSSTSKSSSQKIFRGHKRRFEEMCAENNITSISTFSRPKSPHRASCSASTSVSGDKALDLSISLAEKASSFTYNQETFQHYYPLDQMRPLTPTTPLSHFGHSCSCESCTLDAHRPLTPYFADELPRCLTPLDPGSSHDAGQSPLHSSYLQDDDELSNSQPPPKFFIPPPPSLQSGDQNSQSCTSPSDGPSSGSDSPSQPGGSHLEFALKSDYISVNSQESRRSTDSKFISFKNYGDTFDQEKVSETHKPEPQNAAHPPAKVTMTMPLPLHPSVQSSSRDNSVNLRCALEYSNDSTPLHGNYSDSVSDGCSNCSNCSCTPSISSTPGLSPSSTPGPNHSTKYPLFHSQQKLSTASPPNLVQQPHTQFEKKNASSVPVMILPSDKMTVPLLQISNRGADAAPPIVQVFVMNQVTQPSSASSIGSALSTFSMVAKSANFHPIAPAPVSVATGESRSDDVSLSDLHRRRSHKCHVPDCGKTYFKSSHLKAHIRTHTGEKPFVCDWEGCNRSFARSDERSRHHRTHTGEKRFICDICKRRFMRSDHLAKHLRRHNNGKKSSAWMSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5U5</accession>
    <name>A0ABM0K5U5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial potassium channel-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109423.1">
        <property type="nucleotide sequence ID" value="XM_005109366.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855144"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037660">
        <property type="entry name" value="CCDC51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624:SF1">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109423.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="46525" checksum="D38188655627284F" modified="2025-10-08" version="1">MAAPLRPTGVLCLLSRIHNVKVNSRLNVQNFPQHFYSHFSPLAIYKSKAGCVSLTLPNGSSRRGKYVLSRQKSTESSTNRTHIPEKVGPTQDGTVVTSSINGDLNNGRLGHFMQMYEDFVGLTEVKHAQDKVVKAEQQFLQVQEDRRTMQQEITTVQAEVRTLGAELEKTNRTDSKYIDLVKKEHEILLVEKDMTNRIKALDKAERDFFSLLSAAVRESHEKERARAEKTKYWSIIGSVIGAIIGIVGSTVNNHRRMTQMRAILTESGESTAEYKAMTDKLLQTISQNSTSESFHFLQNTESSGVNVQKQGFEPDSFVVSSQLMEKQREEILHSIDKQSAAVISQLDKIHRLVGVQRAQQGETNVVYVGPEIQTMLESTRESLGERMKQNTLASTAAISGVLSIGVLALVYVIRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5X3</accession>
    <name>A0ABM0K5X3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101849411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005109481.1">
        <property type="nucleotide sequence ID" value="XM_005109424.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849411"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="45"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005109481.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="52015" checksum="E4F82BD7A25E9E41" modified="2025-10-08" version="1">MAGESESSNTAPHVQTKQPHLSKQDLTTLDIKTLTPLTPDVISRQATINIGTIGHVAHGKSTMVKAISGVQTVRFKNELERNITIKLGYANAKIYQCDNDACPRPDSYRSCGSAKEDSFVCDKPGCTGRFRLKRHVSFVDCPGHDILMATMLNGAAVMDAALLMIAGNETCPQPQTSEHLAAVEIMKLKHILILQNKIDLVKESQAKEQHEQILAFVKGTVAEGAPVVPVSAQLKYNIDVICEYIIKRIPVPVRDFLSQPRLIVIRSFDVNKPGCEVDDILGGVAGGSILRGVLRVNQKIEVRPGVVSRDQDGKLICRPILSKIVSLYAELNDLQYAVPGGLIGVGTKMDPTLCRGDRLVGQVLGAVDALPDIFSELEISFFLLRRLLGVKTEGDKKGAKVQKLSKNEVLMVNIGSLSTGGRVLAVKADLAKIGLTSPVCTETGEKIALSRRVEKHWRLIGWGQIRRGVKITPESQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K669</accession>
    <name>A0ABM0K669_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101851448</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005109661.1">
        <property type="nucleotide sequence ID" value="XM_005109604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851448"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="53"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005109661.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34057" checksum="0F13B7A60C422EDB" modified="2025-10-08" version="1">MTTDMSTLTTDLTPDLTSTTDSQDSILTPHQYNAIKWSLVALQVLVCLFGLVTNIVNIIVFGKMGVAESAVSLTLFSLAVADLGFLVTYFIFLLITVALAFELDLIYHQSLSISVWSFLYKISTAITVYLSLQKMFCVAIPFTFKNVFTLRRTVEVLMLTTVIIAGFYVPMFASYYIGEFKDPLNNTTRRALAQSPSYRGYRDIQEIAMEYVLPFSAQIIVIICLVVLVTKLSRASNFRRRNATTKTTDEDSANSGASGLSGKELQAVQAVVLVSAMFVTCNLPPMCSTLAMMVEPEYYQFGSYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K732</accession>
    <name>A0ABM0K732_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005110284.1">
        <property type="nucleotide sequence ID" value="XM_005110227.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857684"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005110284.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52353" checksum="A669128376F8CF58" modified="2025-10-08" version="1">MPGYIAVDKHRFNLEGLQLLVYNSSSENVQEKAMTRLRDIYWKNEPHDLEYLTQCMLIYTDKVLRDNEFFEAARRINPSLIVLDNLPYWRTLSVLAYRLGVPFAYLGTAYIPAMDRIPISFGALPTMIKEYTDHMDFWQRLTSTVLNSPVLFFHIFSHADAVQRYAPEMAFINQFELELKAEVTLVEQDHILDYPQPTLPNVIRIGGTAVCKAKELKEPYKSFVESSDQDIVVVSFGSYVLNIPEQISTKMMNAFLRLKLKVVWRVNVTSANPQQVMTSLWIPQNDLLGHAKVKVFVSHCGKNGQYEALYHAVPMLCLPLFGDQPYNAVRSSSRGYGLTSDVRAMSEDDLVTMINELYYNASYSNNIQKASQIFKDIYGLPKERAAFWLDHVIKYGGSHMRYAGQDLQGYQFYCLDVLAAIALIILCALFVLYFVLKIFVKLLKSVFKAASHKSKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7Z0</accession>
    <name>A0ABM0K7Z0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101861007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005110944.1">
        <property type="nucleotide sequence ID" value="XM_005110887.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861007"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20342">
        <property type="entry name" value="BRcat_RBR_RNF217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20350">
        <property type="entry name" value="Rcat_RBR_RNF217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047551">
        <property type="entry name" value="BRcat_RBR_RNF217"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047552">
        <property type="entry name" value="Rcat_RBR_RNF217"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="576"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="338"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="763"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1031"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="838"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="854"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="878"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005110944.1"/>
        </source>
    </evidence>
    <sequence length="1076" mass="118900" checksum="421784EA13BB375A" modified="2025-10-08" version="1">MHVVDQHTNMAEFIESDQLSKAKEVHIVSSNLESQGKQKCPCSMAEVVSLSKMSLDDEYRVVDSGKLPWTRDDSNDSLAPTTTASLGTIKKRNRAERLDQSQCTSSTDSSGSSTYLDEGDCRLASKSDNIDDLPDNPKEFNFCQVEIMDTNNTKYVPTTSNSEGRIATPLPVRIFSLESPNKGTSKESKSTPSHSESGRHTRDHPTQKEGHEYFSFKSAMLSYGPPWDEVSLSSSDSEDVGWRREVEDDLMVGDRILSGEGYDEIMGSVYSFPSSGAVAQFDQAYDMLLSLMMDDGTLGNLGPDSADHVEVPGASNEDVRRTRGTQPTAPLYPHHPTRYMECEICLSKSNFWSRFCCHFKVCNECVDTYITLKVQEAVVHIECPNDKCRGYIHRNEIRDRLSDELKHKFDKFLVDANKDPCKKTCPACSSVHTIDPDALTTKKKRKNGLKVQCSECHLQWCFLCQAPFHTGVTCKQYRKGDEMVRKWAKEVKHGKFNAQRCPKCKTFIQKTDGCDHMKCTQCSTDFCYRCGDRYIRIKFIGNHFSRFSLFGCKYRLMPKKPVLRRLIRGTNFAARMVAGVVLAGLGLAAGIGLLGASVFILPGYGIFRLHRHRKIAKKRKHVERRMHYMILEMERERALKEGDVALNSQGNTSTGNEESEVENPDPQQVQVIVHRAVSVTEEAGEEPSGDCELYANRFTAEGTEVMVEPSAGEGGEEEGEENFLYVADIKEVSNKGGYSTVVANIVSKVGQVVEDACARSKMADVEKTKVPGGDAQVVGKGEERDGKGEERDGKDGKSGKLEEEEEKVESSSGQTESTGLSSQTDTQVGVEMSQGMTDCDKVSHCDKVSRRDSSVPSEETQPSANSKNLDVTIIVQDDVNKGNTDDSKSSKLDSRGSSMEALHGCFGNIFSKRSQNMLTAEGDAAPKSFEPGLQTKFLHRKSATWEKIRNSKVESVLNFPHFEKVVDGKAVLVHRSPSAVSAMTTSKDFSSLALSEKDCGSTDHSLDSIKGCRGDAGLDCPKENSGIVGAETNPSVGCGEEERDTSGKTTVQEADHAGYLNVDKFHISQYSVVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8E0</accession>
    <name>A0ABM0K8E0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC101853507</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Preautophagosomal structure membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111229.1">
        <property type="nucleotide sequence ID" value="XM_005111172.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853507"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="19">
        <location>
            <begin position="37"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_005111229.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="27906" checksum="E20FB397BB424A66" modified="2025-10-08" version="1">MLCVINTPLRTIFQILVVAGIFLVGVVRTFDECEKLTPCSCKYAGGEIIDLSPLSGNPRWSDQYDTQKENKYSYNPCKGFSEGTCTDVSICQNTGDSYYECGTQESAVFLTNPQTGELSVIYESTDTFNTTRTSQVYLQCAEEDAPDSFVAAGETAPGSGLYLFTLSSPHCCAKKDSDDSSDLSIGTLITIGVGILVIVYVVVGIIIQKFMLHKSGKEVLPNYDTWSRLPRLIKDGIMYTVRCGKTGSDYENLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8H7</accession>
    <name>A0ABM0K8H7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859827</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111331.2">
        <property type="nucleotide sequence ID" value="XM_005111274.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859827"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046726084" evidence="2">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111331.2"/>
        </source>
    </evidence>
    <sequence length="118" mass="12482" checksum="473D6CF3E4F8A3BE" modified="2025-10-08" version="1">MYRLFELVLFVLFQSAKEKRDATTSTTLPGELFQSKSEQGGGAVGGYVSDRASAPSGQTVSIATQTGEVTVKESGLAGGMAAGLPLTPSLAMYHGSWPMENGRWMLSICRGEFSGQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8Q8</accession>
    <name>A0ABM0K8Q8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myosin-2 heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101857690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111503.1">
        <property type="nucleotide sequence ID" value="XM_005111446.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857690"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF16">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="957"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="780"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="393"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1044"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005111503.1"/>
        </source>
    </evidence>
    <sequence length="1318" mass="145881" checksum="A0466CEB77C6C3CB" modified="2025-10-08" version="1">MATKDKIKKKKGNPPVAKASDKSEDQDDKSETGSVGKRTLIEVAEKPVNDEEGQKVEESPENVAEENKKDSGREKVRSETPSPPPFEEKSSNKTLDSVASPKYGKRRRSPVPFTQNKVEPIASGSKDMSNPGSLVSLQSAASVKEAWTDNEEDKKRPGSSSSRRSLLSNKVDKKSQSRKPSSTDVTSIRPTTAEQNAYIPYLYARNCIVQITDDMKAMKHNHIRIVHDIEAHYRSLEGESQTQFMAFVVQYREKFSGKMNTFRNTLEQFRQETQAKELKWNEEVASLNEKNTKLLQEKNEALFMSKEEVEKIDAEKVALAAQVTALAGGVGAAEYAKLQTENKELREEISKLQASPGSKESTVHVETEKAVPVLGAVPVPVGGRSSEEDDEARRQWTEQILRLQEDVTELKLENAKLAAINESLQQQVQQSSQLTERYAALENQYKALALVALEAPDSKMKEQLSKTSEDENMMKEEQQRLQSEISAWEAKFEKKNGREPTEDDKPDSVKELYIQHQEASTMVTSLEQQKETLTKLNSGVVPPAPESVTTGAEVAQPEVMTVEVKVPDPEVVTALEASQQEVSDLRSQLAELSALGGAAAVGAAASDDVVDKSEMDAANAALLQERAAHDNTKAELENVQKQLDTLNETLITEKAQVEAKMEEYKRILEAKVAAREEEISSLKQRKEELEEERLKDVPLDTAKEIKNLQNKISVLENEKSSVSVAQAGVQAQLSELTAKLRVSEEALDAQKAKQSQLEERLKVARKEKDEAVRDLTKLLSRKEPGRVTRQKSQVGEGPQGRGDVAGLKRENQELNAKIRQLEREAIVGGAAIVGGSASDKNVQKRHEKILKELEKRYDMERAKNSKLNENLKIKEDEASSLQKDLNKADVQVAKLSAELAALGIAAKEGVQAAGKVKALESENKKLLDENKTLTENFNSERVLRKKYYNMVEDMKGKIRVYCRARPLSSTESGRGNVSVLKSADEYTLSVASQRGLKEFQYDHVFMEDSSQESVFEDTNNLIQSAVDGYNVCIFAYGQTGSGKTFTMIGDSSKKFPGIAPRAFERIFELAEENKSKFSMSVTVYMMELYNDKLIDLFAKAGTSDDERMEIKKDKKGLVFVHGAIVKPASDAKELNTLFEQGSVNRHTASTKMNAESSRSHLILSIVLESTNKTTGTVMKGKLSLVDLAGSERVGKTGATAEQLKEAMSINKSLSALGDVISALSSEQSFIPYRNNKLTMLMQDSLGGNAKTLMFVNISPADYNVDETVISLTYASRVKLITNDASKNADNKEIARLKAVISKLKRGEAVAGEEEEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA26</accession>
    <name>A0ABM0KA26_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101848165</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101848165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112544.1">
        <property type="nucleotide sequence ID" value="XM_005112487.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848165"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF229">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="550"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005112544.1"/>
        </source>
    </evidence>
    <sequence length="961" mass="105056" checksum="99102EDC157B16BA" modified="2025-10-08" version="1">MSGQVDSQKDRSVDGKTDRTLDQKDMTVDGQTDTTLDQKDMTVDGQTDTTLDQKDTTPDQKDTTVDDQEDMTVAELAQSGAVRCSWCQDTFERPVMLPCLHTFCQLCVIDHILILAEGETNERMEKAQSLREAGSETDITDSQSPESDTRVSQAPETDIGDSKAPETDIGDSQAPETDIGESQSPETDIGDSQAPETDIGESQAPETDIGDSQAPETDIGESQSPETDIRDTQAPETDTGDSQSKDTDVRNSSSKETDMGNSPSPDTDPPNTLSVNPPYVTISVPCYLCQKTITLSSLVPLNDLETLLDRKRGGALKEKNTAVETPPERGGDDRPRTLAEELMMVIEERSKNKKDGQESEELDLEDSLERAARAASEFRAALASIQDLVKDSVSPGKNGGHSRTNGRHCSFLEKTNSWPASKSIRKALVTMVVEECLPVNHFMNSVSHLNHLKSDTPKHCDYCCLEKDSGSESETESEDDGDGDGDGDGDGDSAPRREVPAYGRCLECGDNICAACMKAHRKTRVTSSHKVAPFTSICQGLYDYDIRQTQKRVPCDLHPGSDLSHFCTNCNRPVCQVCRCDKTHQSHNLDSLSDAHGAVSRELLLFVRGFEQRVIMTRDIRENLEKRKAEAKRKLQICRDGVIKWTDYLKNLIQMTSLMPNPVKPPLRVTQINARCPSDTIDPYPTGISVGPVITAVVDRENAAVKLFDATGKYLRSFRGSGNNTLVKPFDAAWLPNGALAVTDPGAGAVRVFDWTGHYITDFKGEIRHPRGIALDMKRWEVVVVDSHLRRLSVHCADTCEQLLTLRPMSGERTGGVVEHASREQLVDPCYVDVTPTGNYVVADAVAPHVKLICRPPGSVSGQQGTVPEEEQLLLAQAVDYGAREEETLRPGGVCVDKFGQILLVDTLNGRVHRALPDGRLVGVVVGVVDGLSHPLCLGLDRHGHVFVAQAGGHIVVLEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA49</accession>
    <name>A0ABM0KA49_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 37 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101863479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005112604.1">
        <property type="nucleotide sequence ID" value="XM_005112547.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863479"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005112604.1"/>
        </source>
    </evidence>
    <sequence length="752" mass="83720" checksum="3B5CFFB3C054B9FC" modified="2025-10-08" version="1">MDEPTDLSVGAVGLADGVHTKHEIDSPMSAGSVSEQTVEDSPNMKEEETYKSRSSPGVEGQQLSRNDGINHGALVMQMKPGIDGHDFETEIRLHQVSNEWVPSSKGSNKGAKNDQKTYKFTSDNDSGNSYFSLCQNVTGTMNTDSKNINGDCGQGKTQTLTDSSGELIQIVKTEPLSDCEDEVQPEVENFVKQEVSDLESPDFSEIGKTERQEVGDAEDQMCVDPTSGEDHISQAGKHQPQVSNSNSSCKNQSSNPVTPAAASSSSTLSAHPALLSLLERRVTSSGPAWNQDHNLSGVNDALTGGLKPAQEKLVQKRRDDILSCTLETKQTAHQRKVNNVLRDVAASGDVRAAVKSLDLQQPSAAENKQFMWSKSLIDTCHLYLIRSSAMKATAASDESEKDGREAVPKDVSDDNSSNGVVEDTYKVVKCCMSGRCHVENPAECSGKKESDSNCGGSGLNLSLPAVKEKPFTCDFCGKRFSCSGNLKSHRRTHTGEKPYPCDICDLRFARSTDLVRHRRTHLTEKPHKCDVCGECFAKVQELQRHYRRHTGEKPYKCDMCDFSCRKNKDLVLHRRKHTGEKPYKCEVCDVKFARRSYLVVHQRRHTGEKPFICDICDVGFAHKNTLQNHRRLHFGEKPYKCEICDAGFAQKSGLVCHKRKHTGEKPYICEMCNVGFAHKKNLQNHRQLHLGERPFKCEVCGEGFTNRSILQSHSRTHSLERPFLCDICGVGYKWKNTLKIHKMKHLKEKQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUB3</accession>
    <name>A0ABM0ZUB3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934624.1">
        <property type="nucleotide sequence ID" value="XM_013079170.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858920"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19344">
        <property type="entry name" value="Wnt_Wnt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF70">
        <property type="entry name" value="PROTEIN WNT-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012934624.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40750" checksum="6877E92CD462DABF" modified="2025-10-08" version="1">MARKRGRMTRTGWFVLVLSIHWILLLQCCCVASWMYLGVASLAGSVHDDTCSEVPGLVREQLEVCKDNPESLLCISEGARRGILECQSQFRFERWNCSTEKNYTVFGPLLRKGTKETAFVYAVLSAGVVHSVTQACSVGNLTDCSCDMSRYGEADVEGWKWGGCSDNVNYGLWFSETFVDAPESATQTGRNIRSLMNLHNNAVGRKTVEKLMSRQCRCHGVSGSCAVKTCWRGLPAFKDIGQYLKNCYERSVRLAGRSKRRLRRKEKARRREPITNEELVHLSRSPNYCRNNPKRGILGTTGRRCNRTANGAESCDLLCCGRGYNTQVVRHVERCRCKFHWCCYVECKTCETLVDIHTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUI5</accession>
    <name>A0ABM0ZUI5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable serine/threonine-protein kinase yakA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934738.1">
        <property type="nucleotide sequence ID" value="XM_013079284.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846487"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012934738.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43390" checksum="9B3F307FF0A0F942" modified="2025-10-08" version="1">MAHLMPEAGSDLREKGDVFRNQLVLPNPNTDKSGHPGERFRWTDAGEAQVNFENQLQQQQQQQNYWQIQQQQQQQLYHNQQQQKQQQQALQHQQQQNKCQHSNQPQRFAKGSSTRPAHLARCSLIPRQPETTNTLQAVSISGDPVVDPYYQLDPAMSGQAPPSPEHAHNYCYDAEGEEQSPTCCTTTTDKLRRSNPATPRPQKNQEQVTKPRRVVTCGYRPVYHHNGKQEAKRRTCPWKGQVDYCYPELDFGSCPMPQAKRRRCYSEAELAGTGWGYCPPCVDDPRELIRPRDPRTPDSARPSGAPYFNHSEKCCPHTEAPLAIKGGFNFCDWLATVKDREAPEEFENSCFPSLCVWCAPVYVDCCPHYDDPAAYTIAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVC8</accession>
    <name>A0ABM0ZVC8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peritrophin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106011157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935252.1">
        <property type="nucleotide sequence ID" value="XM_013079798.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011157"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047160422" evidence="6">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012935252.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="26713" checksum="391FD0CBFD079905" modified="2025-10-08" version="1">MNAMLFVAALVLGLACAAPSREKRQIQNCVDPFRNVPSPCQNNPTNQVYFPHPTDNSKFLQCDVYDRMYIIQCPVGEVFDATLTACRPRTATVTTAPFRPPIYTAAPITQAPATNNPCTATAISRGQVYFAIATDKNKFIECDLAGNPNVLACPTGLFWEQGLLSCVYPLNAGGAAPLNPVSTLTGSVTNPCNAQAINSGHFFFPHPNPAKFIQCDLWGQVFEVDCPAGLLWNAYQETCYSPSPISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVW8</accession>
    <name>A0ABM0ZVW8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extensin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935628.1">
        <property type="nucleotide sequence ID" value="XM_013080174.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852837"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935628.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="22908" checksum="C8238063B2C3A4FA" modified="2025-10-08" version="1">MTIGESMCCCILVANAVSGGDTTSAVFVMVLPISDHAPPACVIPEASACVSPGPSAYVSSAPSAYVSPAPSAYVSSAPSAYVSPGPSAYVSSAPSTYVSTAPSAYVSTAPSAYVSTAPSAYVSTAPSAYVSSAPSASSESPTSALRNTLQKFALICNQVDATTLQGYFKRVENGSPGEPLFDRWKIYYTELTTPRPAEPVFQTPQDPLRAPIPETRKSLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXA3</accession>
    <name>A0ABM0ZXA3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">R-spondin-2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101847482</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the R-spondin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936411.1">
        <property type="nucleotide sequence ID" value="XM_013080957.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847482"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051514">
        <property type="entry name" value="R-spondin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043601">
        <property type="entry name" value="Rspo_Fu-CRD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987">
        <property type="entry name" value="NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987:SF7">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15913">
        <property type="entry name" value="Furin-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046686318" evidence="11">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="R-spondin Fu-CRD" evidence="12">
        <location>
            <begin position="40"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012936411.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33997" checksum="51EB18B893D5D569" modified="2025-10-08" version="1">MLWLTFLVYHLILCEYLFRAVKASGRVKRTIIGRYPVCPRGCTACSRVNGCVTCEARLFMFLYRQNMREIGICTPSCPVGYYGVRHQYYSKCYKCHIDHCHSCFSRHFCTLCEEPYLASEGQCIEECPRGLYYANFTRECKEKVDCLPGAWSPWSVCTRNGQTCGYKWGVQTRTRQILQDASPNGAQCPEVTGTQRCRLQQRHCDGECNRRKRHRRKNKRKGRRRKWPRRRGGRRGGRRGRRRGTRRRDSRLYSHRKRKVRLRRLCRGRACQRKRKCRTRRIRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXD1</accession>
    <name>A0ABM0ZXD1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gigasin-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936449.2">
        <property type="nucleotide sequence ID" value="XM_013080995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852011"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="3"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936449.2"/>
        </source>
    </evidence>
    <sequence length="354" mass="40206" checksum="7B7426B9EE28C190" modified="2025-10-08" version="1">PALTLSVVKDGRVVLSQGYGHTSVDKKIRVTTRTKFGIGSLTKAFTATLISKWVHEQDNIDFDTPIKEFYPAFRVVDEIRTQGATFRDLLSHRLSVDDYFKSLMMGIPDQYSRAELMARMAYFPASRSFREKFVYNNYAFALAAHVLEKMSGDRKWEEMLRDTLLKPLRMTGTGYVTERRDFSDFALPCAERNGSMVDANPELMYTVSPLGPAGSVYSNADDMAKWMQFVLTEGLTSTGHRLVNRDVIRATFEPSNLAFSRATWATKPNVAYSHVPLSYDMGWVTAIYRGYKLIYHTGGFISYSARLWLFPDLQAGVFLCVNGPVYNKHALLESIMYYTADLLLGERPWLNQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXU8</accession>
    <name>A0ABM0ZXU8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allatotropin-like peptide isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ATRP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936732.1">
        <property type="nucleotide sequence ID" value="XM_013081278.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100533460"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936732.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20464" checksum="03BB53FC77E04215" modified="2025-10-08" version="1">MGSRYRFLLSKRSPTRLKLENTRSTPVTTRSTYTPRQTSTRPRPAKSLVLTMLSAPSIAHTGVALLVLMCLCPFSQSTEASLSRAKRGFRLNSASRVAHGYGKRGYASSSGAVPYPELARDVLDNLRAEEEEKELEWSIMSVDELASLLQSHPKLARALVKKFVDINGDNLVTAEELFRPPTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY69</accession>
    <name>A0ABM0ZY69_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nose resistant to fluoxetine protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101854944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936942.1">
        <property type="nucleotide sequence ID" value="XM_013081488.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854944"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046096647" evidence="3">
        <location>
            <begin position="24"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="126"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012936942.1"/>
        </source>
    </evidence>
    <sequence length="873" mass="99286" checksum="496C2CC69F643DE8" modified="2025-10-08" version="1">MKTIAGILLAFLAVQTVVQDVQCQAIFEKQLVQLKRLREQAETHRATFRAWKTKYDSLDISRKDFLKGAKERISTELRRIEEDNAKSLPTEQNAYSVLRFNTEDAQRHKKTENDRLSNSTLHSSGLRQCFRDSKALLTEAAKFTSWALEMLDSNGRPGPGFFEYRTMWPGSFDECVAVRAEYEQRPKKLRTFRGRYCNAFGDIIIPGLLALPSDVWGLCLPDSCNSTEAFILVYSLLKQFNISEYRLRLIDCHEPIEMPAKTIAVISLVLLLVALVTVATAVDLLLIQWPKWKTQEQSETHTQENGHNNIVYENGSHELTTILGVNSDISEYKPGLPVRLLLTFSAWTNGEMICATSQHKDALGCLNGIRVISMSWVILGHSIFFMLISTDNILSAVMTFMDRWTFQAIINATFCVDSFFVLSGLLVSYPTLSVMKSTEGKISWFSFYFHRYLRLTPAYMLCLAVYVTTLPFWMDGPFYPRRGINNNFCETTWWKNLLYIQNFFHDDTMCFSWSWYLSADMCFYVLSPLMIAPLHFRPVIGFIIIGLFFLATTVTPFVLTMLHYFGPGVGDVAGHVEEGDRVYDLYFAPYCRMGPYLEGILLGYVLNRTKWPIRISRVANITGWCVATATALAVLYGLFEYGNGKDIDLVLSAFYNGLSRSAWGLCVAWVIFSCVSGKGGLINSFLSMPVWIPLGRLTYTVFLIHPILTMTWAFARRTPYYLDDLSIIMVYLACLLAAYSVGFIVSLVFEAPFMGLEKILKKEKFPLYIESAVHFEDKDSTKGCYRRRDGDDDPRWPCESTKVQAKAVQRHTIGRFLEKVKDVSCDPGLIDSSVFSEDLTGCFSHCCIEGVDPRVHVCIIIVTSINDSDNELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY80</accession>
    <name>A0ABM0ZY80_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101863258</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101863258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936962.1">
        <property type="nucleotide sequence ID" value="XM_013081508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863258"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012936962.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16724" checksum="9DAD3ECA5A135DFD" modified="2025-10-08" version="1">MFEVLSGGDNCLNIDDARARIPPEGMPSSVLPNLLIQTLVELCEANPSLYETNQDCAQVVDTCLAYFPENEGCKLYVRECGARKYTECVQNLTFDLCKNTNDRAEVNLESLRISNQMRDGCKAYSPRVACQTLERFKMLFRNWFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ08</accession>
    <name>A0ABM0ZZ08_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101864687</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012937454.1">
        <property type="nucleotide sequence ID" value="XM_013082000.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864687"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20341">
        <property type="entry name" value="BRcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16628">
        <property type="entry name" value="RING-HC_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031128">
        <property type="entry name" value="RNF14_RING-HC_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="11">
        <location>
            <begin position="35"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="283"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012937454.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="65213" checksum="EE8213F76F428ACD" modified="2025-10-08" version="1">MAEGCTEENSRGAGSVLDVAQPRLAEGEDLEDQVNELIALKAIYENEDIEICEHENSQRDLPGGIFNIPIFPPQPFNVKITKDLAGIKRLAFWRLGRHAEAVRGRGRRERQLLKTDEIYEKAREKMESNRGGGSVSGDESEKAAPEEPKLYPVKRLPPVTLTFAFPHDYPTTSPPQFTLSCCWLDKNSLTKLCEKLDSIWEQYQGTPVVMNWVCFLQEELVEHLGLTSPYDLGRVLTHVFTHPAKSSYPEHYPPPLKKKPFDQRGIQTFSNIDEVLPKVLDFNLITCEVCFEEQAGEKFLRLVSCSDHTLCKSCMGGWFEEQIKEGAVSDLTCPGYKCDKSVLPTEVASVVSPELYQRYDRLLLKNAFDAMRDVSHCPRPFCQFPVVMDDNLGLCPKCKHAFCGRCQNTYHGHTPCKLKADMFSTICKEYETSNASRKQELEVRYGKQVIQRALEETRSERWLESNSKQCPNCSTFIQKTLGCNQMKCTKCGLHFCWLCSQAISRSNPYGHYSQPGKCSEKLFEGVDMEQEEQYWLAIEAQIAEEEAARAQEDEEGKFDDAEEVDEWGVPLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZX4</accession>
    <name>A0ABM0ZZX4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mpv17-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106011775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937993.1">
        <property type="nucleotide sequence ID" value="XM_013082539.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011775"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF8">
        <property type="entry name" value="MPV17-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012937993.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31645" checksum="B2C05F746EB1BAFF" modified="2025-10-08" version="1">MATVVVPVLLAVAKAIDWAFTEYLLISNIVSASLLLGLGDSLVQLRDILWRKWAAWRFDFTRTWRAMTVGFVLGVFNHYWYALLDYALTGRSLTTVMKKIVCDQAIAGPFFSSAFLIGMCLLEGKSAGEVYAEWRNKFLHIYKVDWMFWPAAQFVNFYLIPHRFRVFYVNFATLLWNTFLTYIKHKDIGAVQPCGPRSRHSSPIQHRPCSRTKRGRKTQRSVARGRSKSALRRKGSRTRMSLRKRPVRRSRSVCPTRRSSGQSLSSDSSTGTYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0K1</accession>
    <name>A0ABM1A0K1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011851</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938383.1">
        <property type="nucleotide sequence ID" value="XM_013082929.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011851"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20237">
        <property type="entry name" value="PFM_LIN24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004991">
        <property type="entry name" value="Aerolysin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369">
        <property type="entry name" value="LIN-24 (TWENTY-FOUR) LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369:SF6">
        <property type="entry name" value="LIN-24 (TWENTY-FOUR) LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03318">
        <property type="entry name" value="ETX_MTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012938383.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29861" checksum="415F5BDCFAA5B2B5" modified="2025-10-08" version="1">MAPKVVDLDDVLTAWAWTAFLRTRSKDHNKLTFDDVKFEVVWDRVKFLAGKPEYSDQQKLEKPNSQVVFKSVYENKTDHFQEHTFQTERSTVSSCSTVVSKGYTKGIRLELKLGLPDDVMAATAGFGRDVSMETTDECTHEETITWTINSSIKVPPHHRTVAELVVKEQEYTASFKMSTRIRGHVVVVLTNLRDNNSFLKAIEGDFCDVMSSPTAEQYSKNFTVNGKTVTWDVSGTCEFRFGIEQHVQLSEFPLSEVVISGEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0R8</accession>
    <name>A0ABM1A0R8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Scavenger receptor cysteine-rich domain superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101845694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938480.1">
        <property type="nucleotide sequence ID" value="XM_013083026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845694"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="42"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938480.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="17921" checksum="6B56C89E4DDBB3E4" modified="2025-10-08" version="1">MESRIKLLAAQVDKRLTAHLQTVQTLVDSLATDHRKPSQGDLRLVTQWSSGPVSSGHAGYLQFFTGTTWGFICDDGFRPEAARVACRQLGYTHTTGSSGVITSSNHSSVDLEDWMRGYEIVLDDVTCDGGDGGLRLDSCSHALIGHHDCHVTEAVFISCSPANQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0U2</accession>
    <name>A0ABM1A0U2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Constitutive coactivator of PPAR-gamma-like protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the constitutive coactivator of PPAR-gamma family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938515.1">
        <property type="nucleotide sequence ID" value="XM_013083061.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856346"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18672">
        <property type="entry name" value="PIN_FAM120B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026784">
        <property type="entry name" value="Coact_PPARg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15976:SF16">
        <property type="entry name" value="ASTEROID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15976">
        <property type="entry name" value="CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012938515.1"/>
        </source>
    </evidence>
    <sequence length="903" mass="101581" checksum="4DFD439C35C8DF52" modified="2025-10-08" version="1">MGIKEFQEFLETECSSACVSVDLLKISRTFVPKRRPIARLGQVGTNGRFCVVVDAESCLDRLYGGYFSDWVCGGQWNRMTAFLANLVQACHSANMELVVFFNGALENQKINEWMSQQLTQRDKVRYVLRHIANKGTPPPKVWWNQPVFLKEALKMALRQLSVTIACSMDDHHQEVIRFCREHNLQGIIAQESIYTIFDPPRYFSSNNLKLTYKGSLETKEYIMDEIAKCMNLNPNRFCIFAALLGNHILTDEDLVQFRELMPNSDTGKPRRNREKLDVEMIKATCDYVRNLPAVDNLDVVGNDVFKLAKTNKTDLVERFKQSVQYFVNGTQDGYYKKGPHQRGRPPLPHQPGYGMPPGHHNAHSYQDARTQGNAMGDAQSKRSPGLPQPTSEILRVAIDRHQKGLMHPHIYQVLTQGEVKLPVILEDDTTRELPSYIDLYRPLRQTIYSVLLNLNKQKIVHEIQNKDKPNVPQPDFSAQVKEWVVRRGSGRPTYEVVTARPVEWKTPSVQRMWLGQQDGDKDRRLRAFLTIMMSDTSLMLNTNYVPQHLLVMCCVLRYMMQYGRILQRQELEAFLAMSVSPLLHDVQTMQDLKLPNILPRGSQLASLFMSGIETATVANDVCGAPIPWTMICPWLYLDGKLFHYKLLKANNNTPLIDMCDGQMEQVLRVERMRQAILENLRVDFAKPLLPGFYYPYPNMPYPGAPLPYAPAGASRGRGGPPGRQMGRGRGILGNYGRSPVEAQGGQLEIAGVVVGQWGPNTSNRRGRGGQMPPQVMSVGQRGRGLYNGRGGFLPGRGGLIRGRPVAPLYSGRGAYRPGYYGRGRGSPSKRPVRIVARPGRGRTVKAAPAKGRGVTVDVSSTMKSKTNEQDYDEVDEEVNGGYSGASEDEEEEETSNATVSVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0V0</accession>
    <name>A0ABM1A0V0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101863816</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_012938534.2">
        <property type="nucleotide sequence ID" value="XM_013083080.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863816"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012938534.2"/>
        </source>
    </evidence>
    <sequence length="440" mass="50800" checksum="333D599F616BCC47" modified="2025-10-08" version="1">MRCRAKRSLLVTFAFAFLITSGFIYINILQVGETIDIQLGIERDLKRSTNEVDPVPSPQPQLHTTTQHPLHTEVEERCHHMAAANGKMRPINRVASFPMSPVISRRRKLLYCPLAKAGSTFFTRYIMAVDRPGPMTSPYDIKIADAGRNGLTSLTDLTSQQEKTKFISESFKFLFTRDPYWRVFSAYVDKLYSPNPVYWRDWGVPAIRDSGLNSSEHKCGSGVPFGAFVHLVVTRLWRSDLHFVPMTTMCNICKVRYDFVGKLEKASSDIDNLSQKLNVSSSFLHENRYKTASTLDVIKDSTEDSLHSWRREVTECTSALDVGKVIWRRLQIRGIIQHDFHFPYSEEEMESISPDDFRSRCIKATETSTDRDKLKRQKLAAFKAAYSQVSLQDRQRLTEIYHDDFYLFGYDPKPAVIFEDNRNQTSVSYILNWRNDWVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1F0</accession>
    <name>A0ABM1A1F0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Histone deacetylase 11 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC101858343</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100021.1">
        <property type="nucleotide sequence ID" value="XM_005099964.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938882.1">
        <property type="nucleotide sequence ID" value="XM_013083428.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826077.1">
        <property type="nucleotide sequence ID" value="XM_035970184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858343"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09993">
        <property type="entry name" value="HDAC_classIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044150">
        <property type="entry name" value="HDAC_classIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035826077.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="64588" checksum="C188CA9BDD471D85" modified="2025-10-08" version="1">MAGASGKTPAPAMRCRQYEAEIKLTQWPIIYSSEYNIGFCGLEKLHPFDAGKWGRIFNFLKDAGMLRDDTIIEPMEASETELLLVHTKRYISSLRLTNIVEGINEWSMNVAGITEVPPVALLPNFVVQKKVLRPFRFQTSGTIMAGRLALDRGWAINIGGGFHHCSAERGGGFCAYADITLAIKFAFEKVESVAKVMIIDLDAHQGNGHERDFMNDQRVYILDVYNRGIYPHDGFAKRAIKRKVELGHFTDDETYLTLIRRHVDGALNEFEPDLVVYNAGTDILEGDPLGNLSITAQGVIERDQIVFQKCRTRGIPIFMVTSGGYQRETARIVADSILNLKNLGLISWTEAENAPLIEAPVSALPRSGSDGGLFARFKRSCLSRPSTSSSLNIAALVSPSEELVPPPTLDSVNMNAGTPSLHSIETNVGALTLNSDKTGTGLCLSKEKDFFEPGTSAQNDYMHSTKVKCANHDVNGLSSSEGHNVNEINSTVHDSVDKTNSSVHYDVRKTNSSVHQNVKERNDSVLNDKNETNVGVLVDVNETNSCLHNDVSVTEVTASFAETTSPITSVPAVSIHIDEQSDVTDLKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A258</accession>
    <name>A0ABM1A258_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012092</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939302.1">
        <property type="nucleotide sequence ID" value="XM_013083848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012092"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF67">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012939302.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44983" checksum="045537E685E5F6E0" modified="2025-10-08" version="1">MVTLRLKGRHTNTSIIQCYPLTNDSEDESKDYFYEQLERELTGIPRHDLIVVMGDLNAKVGEDNTNYWTTMGQLGTGTIHENGERLVDFCALNNLVIGGTLFPKSTIHKLTWNSPNGRNKHQIDHPMIGGMWRRSVQGVKLSDGNVRSAFRLELKNRFQALQDLEETTPNTDEVNTQGKHIVEAYTESSKTCFGVKEKNASKEWIQQGTWNTIEERRKIKKRQLAAKSIRLQEKYAEDCKEACQKVKRLVKKTHKREAMEKLATEAEETAAKGEQGNVYKITRIICGKYHGGTSGPIKDKAGKLLTIEKEQEARWTEHFREVLNQHPPEDTPDIQEATLDLDISSDPPQKHEIVKAVKSLKSRKSPGMDNLNTELFKVDSELTAAILQPLFKTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2U7</accession>
    <name>A0ABM1A2U7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tetratricopeptide repeat protein 21B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101853946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939707.1">
        <property type="nucleotide sequence ID" value="XM_013084253.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853946"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056836">
        <property type="entry name" value="ARM_TT21_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056834">
        <property type="entry name" value="ARM_TT21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056833">
        <property type="entry name" value="ARM_TT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25058">
        <property type="entry name" value="ARM_TT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25068">
        <property type="entry name" value="ARM_TT21_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25063">
        <property type="entry name" value="ARM_TT21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25062">
        <property type="entry name" value="ARM_TT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat" evidence="6">
        <location>
            <begin position="12"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="5">
        <location>
            <begin position="281"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="736"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fourth ARM" evidence="9">
        <location>
            <begin position="772"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="803"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="965"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="8">
        <location>
            <begin position="966"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B C-terminal ARM" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012939707.1"/>
        </source>
    </evidence>
    <sequence length="1330" mass="150280" checksum="5FA1288597152531" modified="2025-10-08" version="1">MAEADPVTVAKINYYCQTGYYGHMESAASEGLQRYGNDPVLKFFVAFAKVLQNRVQEGMRELDMLKDKRDVNLCSTMALMFAHKKSGSTDRDAIQELDMKLKEERKQAGELGLYFAGLFLFNSGKHDKAREYIDRMLKMAPQNADAALSPAATRTIGLTLKGWIELLSGREAKKAIKFFEEALADGSRNVSALFGKAKYFELRHNYSGALELINQVVVGQTNFLPAFVEKMKLQLALQDWDQTLEAAQRALDMDIHCLEAMEYQIVHTLCREGNYTEAASKIADVVTAMDRQETQSSQLYVHMAQVFSKLCGRNSLVLQQTHVLVERAVSLDHHSADIVNEMGCQLMMQGKVKEAMKCHRSAMQMDESSVSALTGIISCQLLLGHVDEAAQQLEFLNEIQQNIGRSAELAYLSAVLAKKKGRGPEKSMELLNEAIELHFAGLKGLPLGIEYFCKLNPDFLLQVIKDYLQFGPQVPVTSGQPISPVLKRCHQVLDPLTRAVPGLMEGLFLIAKVKFLAGDVNAAQSTLQHCLDQDATFSDAHILMAQIHLSQNNFKLANQSLEVGLSYNFQVRDHPLYHLILARILKKQGDSAEAVKTLQMAMALPGVKKIGSRSESGKKSRVEQISVNDRVSVFLELAEAHRQQNEQHEAAKVMQDAINEFQGTPEEVRILIANAELSLARGDIEMALGMLRNITADQPYFVEAREKMADIYLNHRKDKRLYASCYRELNDKHPSTHTCLLLGDAYMSVQEPEKAIEVYESALKKNPKDAALATKIGQALVKTHNYGKAINYYEASLKSGGQASLRYDLAELLLKLRQYDKAEKVLRQALEQDGQDLETLMEHTRYLLLLSQVYSRVDKLEDSQNTLQRAREMQAKVLKRVQVEQPDAVHDQKELAAKICSQLAEHATNQRDTETAIKFYKDALVYSENDSKRMLDLAGLYLMTEDLDGCQHQLMTLLKNDSDNDNATIMLADLMFRRNEYDSAMYHFQQLLQSKPDNYEALARLVDLMRRAGKLEEVPKFLETAQNASSRAPVEAGFCYCKGLYEWYSGNPTEALKHFNKARKDSDWGSNAIYNMIEICLNPDNETIGGEVFDTVEGEGGRMSSDKEKQDSELMAVRTAEKLIREAKPKPGDVRHTVLENMALIASKQKQNIERALNNFMEICSNEREHVGALYGIAAAYMVLKQTPRARNTLKRVAKSPWTIQDGEDLEKSWLLLADIYVQSGKYDMAQELLKRVLQYNKSCCKAYEYMGFICEKEQSYKDAAESYENAWKYGNKNNPVIGYKLAFNYMKARRFVDAIDICHHVLSSHPNYPKIRKDILEKARASIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A329</accession>
    <name>A0ABM1A329_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal acetylcholine receptor subunit alpha-7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939844.1">
        <property type="nucleotide sequence ID" value="XM_013084390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860583"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="61"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="270"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012939844.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="54585" checksum="788B44CB1E593FB2" modified="2025-10-08" version="1">MYSLLFRLCFFLNSKQEAYMRESIAAVQVARMCVALKLVFYIGLISPSSLILASTYNDSVRLYADILKPFDKRIQPVRNQSEPITVYFQMFLINILNIDEVTQRVDLNAWINFSWVDELRTWNPSDYDGISAIHPLPLDTWRPRTLVINSVAKRDVFGDDYSPLYILSDGRSQWLPGTIFSISCDIDIRYYPFDSQTCSMSIMTHDLATDIKLYPDPSTVMTGNFKRNGEWDLVSTRITASSPLFTDVAFSIVEINIVLKRKPVFFVVNILVPTMFISAISSIVFILPEDSGERASFAITVLLSLSVFLSTVSSQLPQNSENFPIIISYLFSLLVLNGTTVFAAVVHMQCRQKKKESTPDSARNDSHHDGPVVCARLKGHFQDGSVSPAWGSGEQQLAVNPGEVNVGQSFIKQDTEQRKTSLNSDDDVALTRETTTGHFKQVNDSHGNSIVMAYLKNSNVLLFVFINTAWLILTSYFLVELIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A456</accession>
    <name>A0ABM1A456_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plant intracellular Ras-group-related LRR protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940459.1">
        <property type="nucleotide sequence ID" value="XM_013085005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846010"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940459.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24505" checksum="E0EE5C50CE9634C9" modified="2025-10-08" version="1">MPGKEKDDKPPPAMGPGSKIKGLIDALRKHLIVTEDKKKRQLLIDFTSVGFKTLPVEIPKNEEVCDLATRFLLQFNKLKKLPGNISELRFLRYVDMRSNQMSSIPASFFKIETLEYLDCSCNTLKSLPGTIKTCQLLHTLDVHDNRLKALPKTINKCSALQLLYAKDNQIRKMNKTLYELGAEIDLSYNKLTDLPTAKIKSPALRRLDVSHNQIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4P6</accession>
    <name>A0ABM1A4P6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012412</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940788.1">
        <property type="nucleotide sequence ID" value="XM_013085334.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012412"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045827605" evidence="2">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940788.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13315" checksum="316CB6CBC8E572E4" modified="2025-10-08" version="1">MRWFRPSCILLLLCLYALAEGKARRDRSGSPHSRRDGGDDKDKHSPESHRSMSGMTKSSRNSHMSAVEKLPNVLWRGTELNLSPTSVVKDAQGDDKDKGIRRNRRVRRSAKKKSELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A534</accession>
    <name>A0ABM1A534_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940988.1">
        <property type="nucleotide sequence ID" value="XM_013085534.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012474"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="168"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940988.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40231" checksum="E2C61E92D2BC6C90" modified="2025-10-08" version="1">MTVADSLSRSPVVSTEPEEFGEEIEAHVATIQMSWDATDSTLDEIRNESQQDPAISAAIQYTRGVWPKFIQNVRSEARDPYAVSSELSEVHGLLVRGNRIVIPKAMRGEMLSRIHDGHLGVSKCRERAKSSIWWLGLSSEIREVVSRCNHCQQKRPAQPSEPLTPTTLPERPFQMVGADLCNYKGHDYLVLVDYFSRFLEVAYNPDTTSETVVYKLKNIFARFGIPELLVTDNGPQFVSDRFHKFAKGWGFKHTTSSPHFPQSNGGSERTVEEAKKALIQDDPFLALLIYRSTPVSPTGASPAELALGRRLRTTLPTLPSNLNQQVYERAKIAARDAKSKRKYKQVLTDVTEPRTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5R8</accession>
    <name>A0ABM1A5R8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone H1-delta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101848676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941360.1">
        <property type="nucleotide sequence ID" value="XM_013085906.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848676"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="8">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012941360.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="19498" checksum="C153290E7DCEE8FC" modified="2025-10-08" version="1">MSDAPAAAPAKATPKKKAPAKPKAPAAHPQYKVMVAAAISALKERGGSSRQAILKYIMANYKVGDNPTAINARLKTALKAGVKAGTLKQAKGTGAAGSFRLGEKKVEKKPAKKVAKKPKSPKKAAKPKKAAAKKPKSPKKAAAKKPAAKKAAAKPKKAKSPAKKAAKPKAAAKKPAAKKAAAKPKKAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6I9</accession>
    <name>A0ABM1A6I9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemagglutinin/amebocyte aggregation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941782.1">
        <property type="nucleotide sequence ID" value="XM_013086328.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858728"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040:SF1">
        <property type="entry name" value="DERMATOPONTIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040">
        <property type="entry name" value="DERMATOPONTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047514448" evidence="5">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012941782.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19773" checksum="8177304C1EFE2A7D" modified="2025-10-08" version="1">MFRYALLLAVCLVCFSQAYRRKYLYCSYCSNGRYVTSLINVQNRPKGDWSIGMRCGGNEAQHDCTFTSVRYEKDNSLHFLCPGNKVLNGFYLYSDNRYVLNRDYSFRCCNIKDKRPKNCNLTPWLNGCEEDLNYQVPEGRVITGLYSLAQNDTSSKTQDRRWRLQVCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A767</accession>
    <name>A0ABM1A767_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101847987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942174.1">
        <property type="nucleotide sequence ID" value="XM_013086720.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847987"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="725"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012942174.1"/>
        </source>
    </evidence>
    <sequence length="770" mass="86872" checksum="A54402CE74897241" modified="2025-10-08" version="1">MPCCGGSDENAVSSIEDDSNQKNYGEPKKFDPNFKGPMANRSCTDIICCFIFLVCVTGLVCCSIVGYARGDPIKLVYPTDSFGNICGEGDYEDKKYLLFFDLLKCAAMGAAVVTQGCPTPQICVSSCPTTYWSYVETVAKEVGAGNTILSSERSKMICKYTVDPQSSAKTVQQYIDDEDCAAYYVKTTAVINRCIPSIFLDITNWAADITYQDGATTYTITDADNSPVTGNELSDASYYMALFYEVKEFVELIYKDVLASWWMLFAGFGIAMFVCMVWIVLMRWLAGPMVWITIGLVFALLLFATYYSYDEYYTLKQLNATEEYGLSQAFALNFSYYLSLKKTWLAFGCTLATVTLILLLLFVFLVKRICIAIELIKEASRAIGNMFSTLFWPIIPFFLQIIFFVYWAASAIFVASMGDSEFYSNTTNTTTNNINYYLNRLPCTPDNSTVGSLCDFVKYGGDEYIIPMQLFMLFMMLWVINFIVALGQMTLAGAFGSYYWAWEKPKDVPAFPLAGAVYRSLRFHLGSLAFGAFIIAVVQFIRIMLEYIEYKLKDSENRVAKIILKILKCCFWCLEKFLKFLNKNAYIMIAIRGKNFCFSAKDAFMLIMRNIVRVVVLDKVTDFLIFLSKALVTGIVFVLSFFWFKGSVTYFDEYVSRPELNYYLTPVIILTLATYLLASAFFSVYSMAVDTLFLCFLEDLEMNDGSVQKPYFMSKGLMKVLGKKNDKMVDPKNSEPNGAKGKKASAKVTPDKKGRPLPEPEGKGKKGKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8G9</accession>
    <name>A0ABM1A8G9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101860687</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942847.1">
        <property type="nucleotide sequence ID" value="XM_013087393.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860687"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045389186" evidence="2">
        <location>
            <begin position="38"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="294"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="397"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942847.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="60734" checksum="BABAC9D8308DF8FE" modified="2025-10-08" version="1">MGETIIPNSPSRDHPAIRLLCVALLALTFNQVPQVKGQDPVILSNNNGNFTYYGNYTSTDVAAVEDVCGKNISWVDIGEQEFMGTPQSVPFKPAKINILNFPYPSSDPVTYSCPNGYDGCDSGGFKISSQENFEEEGQYNITVVLKDPRAKDFVGYYMTVENEEGVGEDRSPLFCPFRSYVAPINTSCFTQYNDGDDFLFVTCYTCYGLPYIECRANGTLFDFAPAPAKCKKKVVDTGALSEFKMESMYPSACAGIIKISALEGPEILLQIRPGKPVPEDVAPWKDFVTTITVPEVRFAKSCLKRSSYTKSGDVFQAQCLCYISEPRKGDYVQWFVDGEKVGELDESGFSTITVEMIVEYDKRKTFSCQGFGAVTQKLPDFVVPNIEVLNLPYDDAPVVSLVEGTCKKTTTPGEVSQCVCRLDQPGNPPGIPTWFNPVGIRLITGSDKADDSSSIDVSENESTQSKLVFITKAESADTRVFTCRAVTDSDTTAPSNIIKYSVKKINSPLYDSTSKTGIILYVLLVVVLVLIIVYTVATYFVCLKITVKDNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9X4</accession>
    <name>A0ABM1A9X4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MAGUK p55 subfamily member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943642.1">
        <property type="nucleotide sequence ID" value="XM_013088188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850753"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10832">
        <property type="entry name" value="PDZ_MPP6-MPP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11862">
        <property type="entry name" value="SH3_MPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="7">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="149"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="234"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="358"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012943642.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="64577" checksum="E43067906A7D5887" modified="2025-10-08" version="1">MPSQRRRDEPPTPVDAVDAMEELREFLADLEDIGASHDELDLLNEVLGDPEYQALAEIHDLLTSKLPSPRDDNASDTLHDTIDIVAAQASTFKKGRELLNILENPHFMSLIYSHDDVARKLYDDVFPEDLDLASPPPPVFEAVGEQHRYVTIRKNGKQPLGITVRLDEMNELVIARILQDSLADKQKLLHVGDIIKEVNGIAVFVPEDMMIVLKEAEESITFKIVPSSSDKLHSKPVFMKACFNYDPMADRLIPCKKAGLPFREGDILDVVDVTDENWWQAKLAEVPDAPVGLIPSRTLQEKRGAYVQPELTKTKTNLLCGLKTKRKKKIGYSSSETTEFDNCDIKVYEMVERSKKHRSSLVLVGASGVGKRSLKERIIREYPDRYGAAIPHTSKPKGAKEQDGRGYYFVDGEKMEADIKRNLFIDHGEFGGYLYGTHQSTIRDVIRSGRICVLDVSPRSLKFLQSPDFKPFVIFIAAPSVEALKVMYNEGKRVNNNARKADSRAELFLEEVFIRTVRDSQEMERQYKGMFDEMIVNDDFETTYRTVVKMMNEQLRQHKWIPVEWNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB04</accession>
    <name>A0ABM1AB04_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laccase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101851770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944262.1">
        <property type="nucleotide sequence ID" value="XM_013088808.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851770"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045941411" evidence="6">
        <location>
            <begin position="27"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="83"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="213"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="468"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012944262.1"/>
        </source>
    </evidence>
    <sequence length="703" mass="79358" checksum="A3CD08C6AD187582" modified="2025-10-08" version="1">MMTSSTYSWLTLGLLVLAWSTSTVLSQDHMYTLPDYKDHPCVRQCENKAPPRLCKYHWVLEVYYVLSKACFNCPFNQSDCSRPHCVPADGVSRGIRTANRMLPGPGIQVCEGDTVEVTVDNRMEASEGTSIHWHGILQNGTGHMDGVAMVTQCPVTSHSKFVYRFKAVNPGTHFWHAHAGFQRSDGLFGSLVVRRPPDLEPHLHLYDYDLPEHVLIVNDWMFDMTINRFAAHHHDGGQNKPDSMLINGQGRYEQFPGDNGTLHYTPRAEFKVKPNHKYRFRVISNGILNCPVQVSVDDHTMMIIASDGNSFQPFVADSFNIFAGERYDFVLYADKVSPLRNYWIRVRGMAACKVNYAHQTAILRYEGAPLEDPPESTTWQEAFRGGIKLNPWNSKGTDTLVEVSRMISTDPDDDTMTSEPDRKIYLAMDFNKIDNDRFNKPGLYPFSAVAKNKHLYSPQINHITSVLPSSPPLSQFDDVPEDAYCNAESVQTNCDLDFCSCVHRYQVSLGDLVELVVIDEGVTFNSNHPMHLHGYNFRVVAIEKLNTSTSLEEVKAMDARGEINRTTSRAPLKDTVTVPDGGYTIIRFRADNPGVWFFHCHIEFHSEIGMGLLFQVGTKDQMPKTPKNFPRCGNWKFSGYDDDEDDKDERDAQDDDDEKPNDKTPSCPNSGEAPSPVPVSRVFAFLTFVLIVVKHLGLDHAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABC3</accession>
    <name>A0ABM1ABC3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein MTO1 homolog, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101846611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944437.1">
        <property type="nucleotide sequence ID" value="XM_013088983.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846611"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="6">
        <location>
            <begin position="322"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012944437.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="46932" checksum="BB7914048FD0E8DD" modified="2025-10-08" version="1">MPFSFMNETVWIKPEDQLPCHMTRTTDQVAQVVRDTLHLNRHVQEEINGPRYCPSIESKILRFSQKTHQVWLEPEGLDSEVIYPQGMSCTMPEEHQLVMMRAIPGLENCRIVRPGYGVEYDFMDPRQLKPSLETRLVANLYFAGQINGTTGYEEAAAQGIMAGINAACQVQAKPPLVVSRTEGYIGVLIDDLTTHGTNEPYRMFTSRAEFRLSLRPDNADIRLTSKGYTVGCVSEERYQRMESMRQKLKENLELLADVKKPTNKWRTSLGLPATTDTNLMSAQSLLCNPLVSLSTLAQAWPSEFGHFLQADPHLLDRLDIEIKYSTDIASQLEEIAAVKREEQMTLPDDLDYFSLNISNDAKSKLAEARPASIAAASRIPGITPAAVAHLLYHVKATQRQGKQPSASFTTSVAKDTDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACH7</accession>
    <name>A0ABM1ACH7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine-protein kinase MARK2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101851085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945084.1">
        <property type="nucleotide sequence ID" value="XM_013089630.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851085"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF79">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="799"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="807"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012945084.1"/>
        </source>
    </evidence>
    <sequence length="923" mass="101191" checksum="2E792E966091E4C3" modified="2025-10-08" version="1">MTITDSMYQVEYLPGVVTQVRKDVIKSFSHSKRVGGYLLGRTLGVGSFAKVKEGLHLSTGEKVAVKVIDKKRAKTDNYVRKNLRREGRLLQLVRHPNVVALYEVMETDNSYYLVTELCRGGDLMDYITARKRLTEPEVTKFIRQIVSAVDYLHRLGIIHRDLKIENLLLDANKDIKLIDFGLSNFIKVSTSPEGTRAQEFCVTQCGSPAYAAPELLNHDKYGLQVDLWSIGVNMYAMLTGGLPFTVDPFNIKALYAKMKERQMNPVPDDLSRECRDLLRKFLTPDPARRVTIAEALAHPWLTQGNKSLPRAPCPNKMRTSDLEADILSHMSENLGYRMGEVIKFVTCNTPSPACATYHLYLLRLGKYKEELRASGQLPAAVACRSENSKITLHLQEMRSKGQRADVTGRGPTMTTPTPRPQARGSGSAHTDTPDCLPGGKGESEDLNDRKENRNPLLKTETLNSGGSPSQSSATTRPDSKAGHNSSALPLRHFQRRLLQEPFTKGNTSIGVTTTAVTSIGLTSIGLTSVGVTPRGVGSPRSGDHTERQTHRTVVDKGGEKGGDRGERGDRGDREQLRLVRLEDKLSLESSHRRAAAPRDRRGRGHYEVVGLPGSDLDSSKASVETSDRVRLKSYKELQQTPLHTPRYGGDNNNNNNNNNIDEEPVTSQNGGGSHTARGGHQHGPPSTHATRLLARRGVVRSMDGSILTPAATVGGSSQDNKTHNAHLAEVTHAHKQLNKKAQVQVQMQVQVVSPRGKGAGGVVVVPPKQYVPFRGVGDRQTPRGAGGDVPLQTGVGVGRAQHKAAPNNNSNNNNNNNNNTTTTESMSLHGKNMFANNNTSVIEEGMTPAKRPVSPHRPVAVRRRLAKRHRIGDITPPGSYVIQDVDQHVTTELIKGDHPVAEQEKTMVHTIPLPSISPTHSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE06</accession>
    <name>A0ABM1AE06_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106013787</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106013787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945886.1">
        <property type="nucleotide sequence ID" value="XM_013090432.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013787"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046809788" evidence="2">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="3">
        <location>
            <begin position="26"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945886.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="42264" checksum="A35BA8E27BCDA90C" modified="2025-10-08" version="1">MTTTQMFALLVCVGVACVLPRPAASHGRLYEPPGRSTMWRRGYDTEENYDDNQLFCGGFWHQFTRGYKCGVCGDPVDGPLDNEPGGKYATGQITRTYTEGQLIHTTVQVTANHLGYFEFRLCEANDPNLKVNQSCFDQNLLEIVESGGTRDYIGSARGDVNLTLRLPAHVTCSFCTIQWKYHTGNSWGTDPDGKQCIGCGPQEEFYGCSDVKIVASGGRDNQGGSSTGSPSTQGAGSTGNPNTQRTSSIGNPNTQGASSTGNPNTQGTSSTGNPNTQGTSSTRNPIPETSPTPQSSSSSPTGSSRSETTATGGGVTGGGAVQYLALDGTVAMDAWCQYNCPLDFCPDWLCYRAAGARNTPAPASGCRAIGPYANSQDMQDWCVNNCALDNCPPNMCACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEF9</accession>
    <name>A0ABM1AEF9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847168</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946116.1">
        <property type="nucleotide sequence ID" value="XM_013090662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847168"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946116.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="52594" checksum="80D423FF10419B48" modified="2025-10-08" version="1">MECSVGVVYPAATLFPTMTPPGTQIVDVCPGNDNKCSYKCVPSRGANHEFWCMAVNSVFGDMRGESPPVQVYVREPPKVAPKLTISGKDFSGATADNTVDVVDGEENSVVCQVDGGFPEVSPSDIYVQCDGVKVTDGKVVFTLDRNATYCTCRAQHPSGCYHLSTEVLVIAILKTEAKLQQSDDEMTIPVAVGAACAALVVCCVTAAIVFCLLKRKGCFLRKAKHEEEQSRSKKTQDNNGSREENQYEEIDVDKMSIPHIHLPALVGKFLPETTKPVCRQEENVYMDVDSDNLTSQDIPTPGLLGKSPSEKMKPVCREQESPYVDVDSVHMSSQQDIHTPVLTGRTMAEIMTPDATQTDGDGRHYNNVLLTSPMATAGQKGKEQPKRNQYVDMDIELIKAKNANTHILIGTTTGKTSTPDNPQAGYDDGRRYQNVSVMSPESAVGHTDQYVSFQPEAEYFNVDIDEDMDGHYSSPRNNSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFH3</accession>
    <name>A0ABM1AFH3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanylate cyclase soluble subunit beta-1</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Guanylate cyclase soluble subunit beta-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Soluble guanylate cyclase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101862997</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012946641.1">
        <property type="nucleotide sequence ID" value="XM_013091187.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862997"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF2">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="420"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012946641.1"/>
        </source>
    </evidence>
    <sequence length="620" mass="70551" checksum="826DDE4D072DFC89" modified="2025-10-08" version="1">MYGFVNYALELLVLRNFGEEAWKQIKAEAYLDMEGDFLVRQVYDDSVSYDLVAAACKVLNVDAATVLQLFGKMFFEYCVESGYDKILKVLGATTRDFLQNLDALHDHLSTIYPGMRAPSFRCTEREKDGATVLHYYSDRPGLEHIVIGIVKEVAQALHDSPVNVEIIQDKGDNCDHVQFAITEANQPDQSKKAELEEFDHTLSSEPKISPASFCRAFPFHMLFDRKLVIQQAGVSISRVIPKVTQHCRLTEMFDMIRPHMEFGFDLVLSHINTVFVLITKKGVLTVDDEEDAHSAMMDERQQMRLKGQMIYVPECDSILFLCSPSVMNLDDISRRGLYLSDIPLHDATRELVLLSEHWEAEYKLAQNLEVLTDQLQQTYRDLEDEKKKTDRLMYSILPPSVANELRHRRPVNATKHTNVTLLFSGIVGFSQYCARHSDTEGAMKIVELLNIVYTRFDEMLDPTKNPNIFKVETVGDKYMAVSGLPDQCDDHAKSIAKLALDLMDISRELKDPNGEQIMITIGIHSGDVVTGVIGKKMPRYCLFGNTVNLTSRTETTGEKGRINVSEYAYRFLQQPLNSDKSFKFQYRGEVVMKGKATPMKCYFLTRKVASPEKKSRTCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VNS7</accession>
    <name>A0ABM1VNS7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC118477223</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118477223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824069.1">
        <property type="nucleotide sequence ID" value="XM_035968176.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477223"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="52"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035824069.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42630" checksum="EDAC4A274EAD8B2B" modified="2025-10-08" version="1">MQQLSKVAMDQWNISRELTSVDSDPDPISADVKYLFDVIITCGLHTSLVVFGSVTNILNVIIFSRIGVMDSITISFVALSFTDFGVEFMNTAERVCMIFSLVLAADEREINVDLDALAYTLTWYAKISYDMSVFITVFIAVQKCCCVALPFHFSDVFTPIKSIVINVTIVCGFLVYHLPVMANQDLRWRFDPRTNSSRLVMWVTKERSILLSINDFGRNIYITASQVIVIICLLILVIKLRKSSAFRRTVASGDESTSKEESSKVKFSTRDLNVIKSVTYVAALFVACTIPSVALAYCRQFIPKFDFTGHANLFLVVFRVRNTFIYLCCAVNIFIYYRFNTKFREETKILFRPFLLRVRLRRDQKEAAKGDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VNW2</accession>
    <name>A0ABM1VNW2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Ribosomal L1 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6" type="primary">LOC101863326</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934714.1">
        <property type="nucleotide sequence ID" value="XM_013079260.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012934715.1">
        <property type="nucleotide sequence ID" value="XM_013079261.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012934717.1">
        <property type="nucleotide sequence ID" value="XM_013079263.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824104.1">
        <property type="nucleotide sequence ID" value="XM_035968211.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863326"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012934714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012934715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012934717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035824104.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36696" checksum="780D4828AC8243B5" modified="2025-10-08" version="1">MTSMELKERKVSTAVGTLVQLAKKLEKKSLVDEVNQVQMQICLKKIPPREKIVKLKLPHSLRHENMEVCLFVKDLDREDRDYEPTVRHFQEMLKKHGVSCVAEIIPLKSLKTEYKPYEAKRNLSNAYDVFLADARVVRLLPTYLGKHFYGKRKTPIQVNLQAKRLKEEIDAALDNSRCVISNRGASSLAIVANLEMGKAEVTDNVISSVGQLSQAVPGGWNNIKQLSVKTPLSTSIPIYLAAGGPQEVTIPKENADKEVVEAEEISTLLGAKVKVYPSGDVEVIKDRDSEGQPQKRGRFRKGKAVGKQSAKTAGAKAKSVKRKAKGRKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ05</accession>
    <name>A0ABM1VQ05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-xylulose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824497.1">
        <property type="nucleotide sequence ID" value="XM_035968604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861346"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051737">
        <property type="entry name" value="L-xylulose/Carbonyl_redctase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252:SF3">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824497.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13136" checksum="1FCF3ABB657EF8B4" modified="2025-10-08" version="1">MNRGSRGTQGNYNMPIEKAAEMEITFAGKRALVTGAGKGIGRDIAKKLTACGANTVALSRSQADLDSLKSEVPTIETCVVDLSDWTSARQTIESLGHFDLLVNNAGVSKVVPFTETSEQDFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQE6</accession>
    <name>A0ABM1VQE6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">F-box/LRR-repeat protein fbxl-1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101852838</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094358.1">
        <property type="nucleotide sequence ID" value="XM_005094301.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824637.1">
        <property type="nucleotide sequence ID" value="XM_035968744.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824638.1">
        <property type="nucleotide sequence ID" value="XM_035968745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852838"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF4">
        <property type="entry name" value="F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035824638.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="59479" checksum="0CE54A2E6FB328FB" modified="2025-10-08" version="1">MDSAFRTTIFDIAQDASQVATAHNENDGSFRASVTIEHVPPKLVLHMFSFLRLCELGKMAQVCRKWRSIAYDSRLWTKVSLRPEFSGLHVYAPEVLQALIGIRFGATLKYIEIPSDLITAPVLHELSNKCPALRYMTLDFSNAMQLHDFNDLNAFPCNLRSLCICLSEVIFLEGFMRRIYSCLSSLDVLHLIGTFELSSESEEDIYEVINISKIKAHTPNLRVVNLYGITFLDDSHIELLASNCIHIECLALNFCLRVKGASFKNLVQRCKKLKSLLLHHAGVEDDHMTSVPWEASSIHELDLTSTELSAHCLENILLRMPGFTYLALGYCEFFNDVILEKLMEKGKFNRLQALDISHTHALSENAIYQFIQMHGTNLKGLMLAGKPKLTENFWLNAIPCLKNVRICVLGTANGWFLKMQSRVHVDQIVEAFAQHCPKLERCEIQWDPDTIRFSDKSNKFIDHVRLRCPSLKSFTLSDGEYYEMVKSNFERADRVKVVRTCTNYTTSVVSLLNNYNDLLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR06</accession>
    <name>A0ABM1VR06_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101859091</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824848.1">
        <property type="nucleotide sequence ID" value="XM_035968955.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859091"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045665616" evidence="11">
        <location>
            <begin position="27"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="300"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035824848.1"/>
        </source>
    </evidence>
    <sequence length="581" mass="62004" checksum="F474F9A470264D8B" modified="2025-10-08" version="1">MFSNKPVGYAALLCLVFLLDNELARQVVLCACPAPCTCTPSSNGQVVVCGTGLSSFPSNLPSDTQSLSILPSAPGQTANIISTVSPSDFRSLLKLVRLRIRRAGLHTIQAATFSKLTKLLSLDLSSNQLRHISRTAFVGIPQLQLLDLTGNTGCKLDQDTFDDLQSLTVLRIGRIGLRTFGNKLSKLQNLQDLDLHGNNLFRLEAKFLASLSNLKHLDVTHNDLRGIEESLKPQFMALKSLKLDSNPWRCNCALSWVKYLPIKFLFPTHYGGGSVVCDEPKNVQSKDLINVPDSDLQCVPARVISCSSSFSVKESGAFTLSCTVEGDPFPDVTWVSPRGVNVSRIVMFGVQNTTSLIVQSSQFSEHHGTWKIIAESYKTEDTKTIQVDVITTTTSVTTTTTTTTTTTTTTRAPTASTGTVNSSLKPTVPHSGSVTPSQGPLPNSGQSTKNVGGRSTAATGNAGPSQGQLKQTTPHTGQGHKPTSRRPGSAAKQSRQPRPVASSKDSTVNIAIAVAAVVMSAVLCCIGVAVLCVAVARSREKARVGIQSDDRTGALGGGKLETVFILTTSENGSTNVQQWTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRJ3</accession>
    <name>A0ABM1VRJ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Substance-P receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC118477516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825035.1">
        <property type="nucleotide sequence ID" value="XM_035969142.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477516"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047160303" evidence="8">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035825035.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9855" checksum="29673C4A732CE7F4" modified="2025-10-08" version="1">MLFTLLITFMVCTLPFQVSTIYENYKDRQTKLPSWYQPVYFSAINLMYAHSTINPIVYGAMNQTFRKGFKHLMDRSVIFLLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUB5</accession>
    <name>A0ABM1VUB5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin-dependent kinase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101862276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826007.1">
        <property type="nucleotide sequence ID" value="XM_035970114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862276"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF189">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035826007.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="39854" checksum="A5F562589F005750" modified="2025-10-08" version="1">MAADSGKPTSKVDMREGKDKDQVGRLKKLRRRISASFGRLSISKEDTIQESDHEEDPHVFSSEVVSTNGYYPHKTRSAPDTPPTVNGSHQVSNGEHREAASTMGRTSTGAKQVVIPRNPAVVFFSRDLKPQNLLISEIGELKLADFGLARAKSIPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDIWGVGCIFTEMISGKATFPGTKDVHQQVQEGGESTAPGMKDIYDQLDKIFFFMGTPTEETWEGVSKYPNYDLSKVLKHRPHPFMLFVPGIVDLPHAESLAESLMQMPAHRRISAHAAMKHPFFQDLPPAIHKLGDTTSIFNIPGLQLQREDGNPSVAKRRHSSRRGIRTVLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUE8</accession>
    <name>A0ABM1VUE8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Voltage-dependent T-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826040.1">
        <property type="nucleotide sequence ID" value="XM_035970147.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864393"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005445">
        <property type="entry name" value="VDCC_T_a1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
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    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
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        <property type="entry name" value="TVDCCALPHA1"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
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    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="88"/>
            <end position="107"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="183"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="342"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="832"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="923"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="1013"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="1445"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="1580"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="1644"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUR1</accession>
    <name>A0ABM1VUR1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101860254</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="RefSeq" id="XP_035826153.1">
        <property type="nucleotide sequence ID" value="XM_035970260.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860254"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="168"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035826153.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47103" checksum="CF731AD73AB9662D" modified="2025-10-08" version="1">MCGDSQSFLMATEELYVKVQQTAADMATSIKEVDLSDKRLQEILSVAKDWAFCTGAITKSGTDEVEAEKALPAPYSLFPSVVPAPILEHVKSTMTHFNRLMHKVSMDHEFLEQSLKNVIQVDPFMLSLWNVYCKVRESGIKQLPDNNPVVRFADGLVKAWELYGNPRAVIIFVVSASELNVVDQRFLEIKVYDRNPNIRILRKTFLDIYNQGHLDDKSRLIMWEWDARLKCELSRAIKCPSVQLQLTGAKKIQQELTRPGALERFVSDPQVVNTIRDTFADQYSLDLNQEGDAAVKLALQSPEKFVLKPQREGGGNNLYNEDITNFFKEYNRSKERSAYILMQKIFPLQQKNYLVKPGVPLVLSDVVSELGVYGVYIGCADSEVVNVACGHMLKTKIHGTNEASICAGFAGFDIPLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVR0</accession>
    <name>A0ABM1VVR0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">39S ribosomal protein L48, mitochondrial isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826502.1">
        <property type="nucleotide sequence ID" value="XM_035970609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862661"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027487">
        <property type="entry name" value="Ribosomal_mL48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13473:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13473">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="3">
        <location>
            <begin position="86"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826502.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24903" checksum="B180392C1E49C007" modified="2025-10-08" version="1">MNVERMTVEGTSLWKPEKEGQMNSRSVCITWSMRNYLQKALLNQSSHKVGLQLERRLLSTPSKWHGLFEPSDLKLEPDIPEFKALHIRMRGYDFPILESYAKRVHSILDTMFELDTDAFPAPSKSTEVRTFHPRSTAVADKYQLNKYERTVMAEDVPTTTVPLIVQFLRKNCPEGVDVAVKEPDTDEEEFRFVPDYEVNDLLAEKAAIEAGKLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVS3</accession>
    <name>A0ABM1VVS3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101852553</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826515.1">
        <property type="nucleotide sequence ID" value="XM_035970622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852553"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF320">
        <property type="entry name" value="SODIUM-DEPENDENT NORADRENALINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 13" id="KW-0769">Symport</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035826515.1"/>
        </source>
    </evidence>
    <sequence length="725" mass="81583" checksum="5F7A7B49EF837ACA" modified="2025-10-08" version="1">MEINVDYVMDPADLWAERFRNKGINKEHDPEAGISMSSRPMDKAENPDKQMESPTDPSKKEQLGEKEVGVVLPMISGSGDSPGDKGGNDGDPDPPPAEKFEISDPPHPDRRDSSDLNLPPREHWDNRFQFLLSAIGYAVDLSNVWRFPFLCYKNGGGAFLIPYFTTLIFGAMPIFFMEMCLGQFHRNGPVAVWEKMSPMFKGIGMASCFMAYIVAFYYNIIIGWSFFYLFSSFTSKLPWTSCFNDFNSENCWQITWDINATVSEDNSSLVDDVMSSDLTGLMSSQLLSTQPPSTRPANRTYDVKTSISSTMEFFERGMLELNKSSGLEDLGEVRWQLALCTFLTFTVLYFCLWKGVKSTGKVVYVTATLPYVIMTILLVRGVLLPGAEEGIRYFITPKIESLRNPKVWIDAAVQIFFSVGSGFGTHIAYASYNKFHNNCKRDCIITVIVNSFTSLFSGFVIFSYLGYMSLKTHKHIKDVATEGPGLVFIVYPEAIATLPGSVGWSVIFFFMLLALGLDSAFGGLESPLTGLRDELSCLLKYRYFRECLTLVIISSAFIFSLPCLTQGGMYVFTILDTFAAGTSIVFVVLCEVVAVSWFYGMPQFCADVEKMTGESPSMFWRVCWKFICPLLLTVVVISSIASYQPLTYETSQGKYKYPYYANVVGWGVACSSMLLVPGYVIYKLIRTRGSCRQRLALGISPQWEHEDIERTGHVKRFQRTHWMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYG1</accession>
    <name>A0ABM1VYG1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118478280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827454.1">
        <property type="nucleotide sequence ID" value="XM_035971561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478280"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045710185" evidence="1">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="131"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827454.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="26712" checksum="BBBF9C4F0FBD6C81" modified="2025-10-08" version="1">MILGTLSLTLATKLLFMCTSASESVEGLIFQKEYCTTVADATTRLSFTTVSSRSGCAVMCIPPCVSFLVSEVSVGSVFQCALLSDTLDLPASTDCTDVAATVGVYIDLDCPVKSPWPECTSDCDAERVVGGTKYCLRNRYSRQTQPAARATCQAEGGDIAEAETLDDVAFLRQFVSVTERTWVGADDSKTLGTYVWFSGRGVSSALFCGTEPNQAFERCLTTNRYGDCLMDFKCEGVSYPFACALPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W092</accession>
    <name>A0ABM1W092_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">cGMP-dependent protein kinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828085.1">
        <property type="nucleotide sequence ID" value="XM_035972192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478490"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828085.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10669" checksum="9AE999FDC0305CEC" modified="2025-10-08" version="1">MGSLQEMERLLHSKDDKIKELQKLLEEKEEKITQLKSKLDKFQSVLPQTQTNFISGPRKRRAQGISAEPQALTCLQDFSKTEFRRYSKTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0Q1</accession>
    <name>A0ABM1W0Q1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="28">Neurogenic locus Notch protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC101861317</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOTCH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828244.1">
        <property type="nucleotide sequence ID" value="XM_035972351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861317"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="CDD" id="cd21706">
        <property type="entry name" value="JMTM_dNotch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008297">
        <property type="entry name" value="Notch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035993">
        <property type="entry name" value="Notch-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010660">
        <property type="entry name" value="Notch_NOD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011656">
        <property type="entry name" value="Notch_NODP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836:SF23">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836">
        <property type="entry name" value="SLIT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06816">
        <property type="entry name" value="NOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07684">
        <property type="entry name" value="NODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002279">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01452">
        <property type="entry name" value="LNOTCHREPEAT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01338">
        <property type="entry name" value="NOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01339">
        <property type="entry name" value="NODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90193">
        <property type="entry name" value="Notch domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50258">
        <property type="entry name" value="LNR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0010">Activator</keyword>
    <keyword evidence="14 22" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 23" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="179"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="334"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="410"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="448"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="486"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="523"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="564"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="603"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="641"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="679"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="717"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="755"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="802"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="841"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
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    <sequence length="2317" mass="251402" checksum="FFBFB434078EB0EE" modified="2025-10-08" version="1">MNSVGSYLCHCVNGWAGRHCEHNEDDCKRQPCYNGGTCHDRVGYFECECPKGKTGLRCHLEDACESSPCHAGASCETSPINGDPICTCKKGWRGQDCSLDVDECLETENSPCEHSGRCINTNGSYYCQCSVGFTGNFCERNINECIGEPCLNDGTCLDQTGKYSCLCMPGFTGINCETEIDECDTPQGNPCRNGGVCEDHINRFSCSCPAGFEGRTCEININECEVRPCLNGGSCLDNINSYICQCQKGYSGTNCEENKDDCQGVTCENGGHCIDGLDAYTCNCQQGYTGRHCEVRVNECNSNPCQNGGSCNDQINGYECKCLRGTSGPNCQHNYDDCRSNPCRNKATCIDGINEYTCNCKPGYTGTHCEQDIDDCDPNPCHNEGVCTDKVNDFHCTCPLGYNDKRCMSDVDECESNPCVNGGRCIDGYNRFDCVCPEGYTGYRCQSRINNCLSNPCQHGGSCHNNLNFYVCQCRPGFTGTNCEININECASNPCLHGNCVDLVNGYKCHCEQPYSGKNCDVKMDPCRPNPCRNQAQCVPQNNYQNLYKCNCPVGYTGNHCELDINECAVSNPCRNGGTCRNTQGSYVCLCKLGYEGRQCEVNQDDCEPSPCMNGGTCIDGVASYNCSCVSGFGGRHCQNDIDECASNPCTNGATCEDYVNSYTCTCRPGYSGMHCQVNDNDCTKSSCLHGGTCIDEENHYSCNCAPGYTGSNCQSRINPCDSNPCLSGASCFNQGGSFHCNCPFGFTGARCESFVDWCSDNPCSNGGQCLQMANDYRCECRSGWTGKFCDIRSITCKAAAALKKVLVSDLCENGGTCFDAGNTHTCECRHGYEGSYCEKEIDECASGPCQNGATCSDRIGKYTCQCAKGFQGLNCELDVDYCANQPCDNGGTCHDLVDNFHCSCPPGTEGLLCEINHNDCLINSCHNGGTCVDEVGGYQCVCPPGFVGKHCEGDVNECLSNPCDPDGAQDCVQLNNSFRCDCRPGWTGHRCSMRIRCDQDPCLNGGSCRDTIQGAVCSCLVGFGGEFCGVATSSCDPDPCLNGGVCGETATGFECMCGPGTDGVLCEIDLYDDCQVEVCLNDGVCIDKIGYYECNCPRNWNGVRCELFDKEFLGGIGRPVSPSKETVPAICKQYNCPEKADNGQCDEECNLMECNHDNTECSYGTMPWQNCSQMVNGLYCWQVFRDGKCNSECNSPACLYDGFDCQQPLGKCNPNYDTYCLMHYNNGHCDKGCNTAECDWDGLDCDEGNEALVSGTLFIIVLIEPEEFHKVKQEFVRQLGHLLRVGVRIKLDVRDNEEMIYPWSGEVADTDESIVSRTRRWVEGVLDGGHEAALSRHRRAVRNGTKVYLEIDNRACYKYENLDCFASTDEIAKFVGAALLNKDYDPVVAVHQIGTQDPSGPDLPGLESSNTQTFVLLMCVCAGILVLTIIVIMMVSRKRVRGITWFPEGFFSKSSDASKPARNRNGPEGEEMQDKLDKMDANDNHTSPPASNECYHEDDDEGLQIKRARIERQGKSCVDGMDTRQWTIKHLDAANVPHSSLLALTPPQGEDGMQAISDVNVRGPDGLTPLMLASIRGGGLGEDDDSNSGSGSAEGGDSDNNTSVDVISSLLMQGAAINAQTERTGETSLHLAARYARADAAKVLLDAGAEPNAEDSTGRTPLHTAVAADAQGVFQILLRNRSTNLNARMHCGGTPLILACRLAIEDTVEELISADADIEATDNNGRTALHWAAAVNNVHAVLVLLKNNANKDVQDAKEETPLFLASREGGYETVKVLLDHYANRDMTDHMDRLPRDIAFERRHHDIVELLDSYKVASPASVHLGGGVTSPNHHHHHAAMAGAAGYMHPGKQSKSKSRKSKNTAVKDTGSVSSPPNGMPGGLPATANGKSKSRKKKADGGDSKKSQQQQQQQQQQLQQQQQLPSSVSSQSQAMLHHSSSDSSPMSTISPGSYSIDSHHSPPGYETSPPRYENSGGLVLPPGVGGSDRGGSALGGRHHLEDFQVMAGHYSSPALMEHSSVDSMLSDWSLFKMQQQQQQQQQQQQQFQQKQQPQQQLAAGCAGGLANGHLGSASGNSPTHVVGPGGGATVLGSVNHGGPAPPMKVKNLPMSPTHIQALQQHAQQQRAAHGSPHHRGNDFPNSFHLDGSGSQLPPSAAAPPPPSVAQIYPLQHKMVQQQQQQQHHQQQQQSLQQQRAQQQHQHITDSPPQLHSTISSFRQDHLPTPSPDSPGQWSSSSPHSAHSDCCFPARCVERTIGAQYNKVGAQEYIAGLSTQEYKATSSTPKYTGVHSCWQYTTQEYIATGSTPKYTGVHSYWQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1Y7</accession>
    <name>A0ABM1W1Y7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycerophosphodiester phosphodiesterase domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101855218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828680.1">
        <property type="nucleotide sequence ID" value="XM_035972787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855218"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23344">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23344:SF50">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="55"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035828680.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="50639" checksum="B3A7C7B1A67E8938" modified="2025-10-08" version="1">MTSIFWLLCRQWFKLRTYAIKCVWLLLFVLLMLGLYLSPLAVDSPLIRSETPPKPNIVALGGAVQVAPENTLMAFQKALDMGVNKLHTTVQISADGVPFLFGDDTLERTTNAESLLPGNASLDPMRHTWVNLTSLDAGSWFLEADPWDTADSLKQQDKDLVSKQGLLSLEDFLQFLSSQPRPSDDMTVFLHYRPLDRHHQGFKDINVAGPHVTDRGAGFIINPVINASALDLKVFATPVTSDRLKGVQGLLETPLSSAVASLVSQSDVAMLELGDVSIEHIRELQRANVSVGVQEVNSEWLLSLLWCVGVEYVATHDIGVLLALGSPVWRMSKGGYLAMWISVDLFSVIVILVMFIVQRVQLYGTNFSPESISLNTGRARTSYRSRTMKEKLLREGGIIEAVDDMEGSNAGAQDADGGVINEPVYCMTSGHQAYSLTSLSAIRVEDGGHSGVVVQAASAAPQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W231</accession>
    <name>A0ABM1W231_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">AP-1 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC101864719</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110316.1">
        <property type="nucleotide sequence ID" value="XM_005110259.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005110317.1">
        <property type="nucleotide sequence ID" value="XM_005110260.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828724.1">
        <property type="nucleotide sequence ID" value="XM_035972831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864719"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="167"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005110317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035828724.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="48539" checksum="C2BE999BA3ABFA6F" modified="2025-10-08" version="1">MSASAVYILDVKGKVMISRNYRGDIDMSAIDKFMTLVMEKEEDSNLTPIIMHGEVAFMYIKYNNLYLVATSKKNANVTLVFTFLHKLVQIFVEYFKELEEESIRDNFVIIYELLDEVMDFGYPQTTDSKILQEYITQEGQKLEIAPRPPPAVTNAVSWRTEGVKYRKNEVFLDVIESVNLLVSANGNVLRSEIVGSVKMRVFLSGMPELRLGLNDKVLFESTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWVESVIERHAHSRVEYMIKAKSQFKRRSTANNVEIIIPVPNDADSPKFKTTVGSCKYVPEINCVVWTIKSFPGGKEYLMRAHFGLPSVMNEEIEGKPPINVKFEIPYFTVSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3T2</accession>
    <name>A0ABM1W3T2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase-like fidgetin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101855393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829325.1">
        <property type="nucleotide sequence ID" value="XM_035973432.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855393"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF72">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="4">
        <location>
            <begin position="143"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Spastin/Vps4 C-terminal" evidence="5">
        <location>
            <begin position="215"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829325.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31055" checksum="E9E1A71B2FCA0349" modified="2025-10-08" version="1">MAFHNDAITCYWYFLSLRETLSEGRKQSDVDIGLMLTNVHRCESIVEQLLLTEQDAVFSVCMFRHTFAFKPSCEREPPPMESEESTAQVRRSIISATISRPTALTFDQVVGLEAAKQALREAVITPLLFPHLFSGETNSWRRILLYGPPGTGKSRLAQALSAEVKATCYCVSSTDLMSSWVGETEKLIKELFQHARSQPGQSNISACKKASNDHWVPCDEDCPGALRAKAADLPTDKIRPRDVQMRDFLQSLSSHRATVCEGELTRLEEFTASYGQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3W9</accession>
    <name>A0ABM1W3W9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein MTSS 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829362.1">
        <property type="nucleotide sequence ID" value="XM_035973469.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860626"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030127">
        <property type="entry name" value="MTSS1/MTSS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708">
        <property type="entry name" value="ACTIN BUNDLING/MISSING IN METASTASIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708:SF4">
        <property type="entry name" value="FI21477P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="3">
        <location>
            <begin position="2"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="910"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="963"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829362.1"/>
        </source>
    </evidence>
    <sequence length="1133" mass="122197" checksum="E7AC333134274AA6" modified="2025-10-08" version="1">MEAHAHPEKDCGVLGSLFQTVVNDMRGSTPLWEDFTYKSMKLHSSLKTTVVAIGAFLEAFQKVADMATSSKGATREIGSALTRLCMRHRSIESHLKVLTSSILDNLVAPLQEKLEDWKKAVAQIDKDHAKEYKKAKQEIKKAASDTMRLQKKVRKGGGGHGKSEMQHKLDSAMAEVNSKYQHLEETEKNSLRSALIEERSRFCLFITCLKPFVDNEVKLLTEISHINEIMDSLCMQASEPSVLPASSEQVIVDLKGVDNSAWNFNQQNSPPSSPSSLGSRKSSMCSINSINSSSSGSSKSHSPSHTMHKRTTSQPLVGAIRLTSVSSQDSGFTSQDTLFLRPNTPQSLSLYQTSTTQERDEGDCDSTPTTPSDNTPSASSTWNNWPNLPGTPRTDPARPHTISSAYEKGHTRPALKPDMFEPPQEGVEMRPKTLRSQSQTSSGGRPSATISKLQPVLPPHCPKPKVKAVAPPMLPPGAQPIYANMAELSGKNGQSSDPSSPDDGEPTTPTTPASVSITQGEQLLKSPKGMMDLQTAIEQMDLCTASLNVEDEPIASDTSEEVTPRSSLDDPQVGGHAEAGEVSADDLVLVTKPKIQQNTSLELAKAIRELEASTAALTSAYDTDNYATTTGQTAAAANSTGPVCDTDSYTSKSSLPCSSGYGTMASTPAGSEDTIASGDCSMPPADSMSSEKYFTIPRSGEASLAYRAALASMRPASTAGIPVSGTNVSRRCSVNSQKPPPPVRRTASVTGSTPVHVQKLRNSPPRQLSADGVEDVYAMGGGEGMVEGPYAELQLIQQSIHGAGGTRPGPATPTKPTQRPPGMGNSHGPGAPVPPSTQEPVATATVIQSLNAKFASLNSQYQDGVEVAPEGVAGVVSPGGGPKGQKPAPPAVMQKPVRSGIPPPPSVIAAQQAHPRVQQQHPQQQQQQHYYHPHQQQQRPNDHLGGHPSAAGRGAHPQDPRRSAHGHPGHQQQHHHNQQPRQLQHGKSWHGHPQQQHRPHQQQLQQQLSHSGHYAEANAHLQHQHQQHHQHQQRQQHRVSGGEEDFPLPPTAEELQEMERIYSRPPPIGPSVQAPVGQRVQQKRQPAMHSQQQQQQQQQQQQQQQQAPQGNAVPASLLMELKRRVSVDDSSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4K6</accession>
    <name>A0ABM1W4K6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">CBP80/20-dependent translation initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC101853523</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113329.1">
        <property type="nucleotide sequence ID" value="XM_005113272.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005113330.1">
        <property type="nucleotide sequence ID" value="XM_005113273.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829599.1">
        <property type="nucleotide sequence ID" value="XM_035973706.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853523"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF16">
        <property type="entry name" value="CBP80_20-DEPENDENT TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="93"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005113329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005113330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035829599.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34092" checksum="702D2CA00C92BC46" modified="2025-10-08" version="1">MAGRGRARGRGRGLGDSEASAPGGLAARNSVDEDESTPEVTQNSNEGESKTASGGVGQPTLSLNDMKSIIEDPRTYSEQNDVKKFLMCARHFVKTEEDVKTLSSMLYNNCLSDSSLAKRGSEICDALTCIEVGSTKFRNCLLSLVQADYKARKELIASDPARFRGFLAFLCEIFGVMRTANNEVFKPLVNPIFDCFILPLGQEDQEEEEGGEGGGGGGGGDMEMLNDDVCELFAIQLQSVGKLLEENEEERMRQLMNRIRTCIIHSKSSPRVRCSLLEVLESYARGWESADSETTKFYCDMAVDMISGLVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-07-01" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>P31319</accession>
    <name>KAPR_APLCA</name>
    <protein>
        <recommendedName>
            <fullName>cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>N4 subunit of protein kinase A</fullName>
        </alternativeName>
    </protein>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Neuron" volume="8" first="387" last="397">
            <title>A regulatory subunit of the cAMP-dependent protein kinase down-regulated in aplysia sensory neurons during long-term sensitization.</title>
            <authorList>
                <person name="Bergold P.J."/>
                <person name="Beushausen S.A."/>
                <person name="Sacktor T.C."/>
                <person name="Cheley S."/>
                <person name="Bayley H."/>
                <person name="Schwartz J.H."/>
            </authorList>
            <dbReference type="PubMed" id="1310865"/>
            <dbReference type="DOI" id="10.1016/0896-6273(92)90304-V"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="subunit">
        <text>The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules.</text>
    </comment>
    <comment type="PTM">
        <text>The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain but is not phosphorylated. The physiological significance of phosphorylations by other kinases is unclear.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="X62382">
        <property type="protein sequence ID" value="CAA44246.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="JH0590">
        <property type="entry name" value="OKGAR1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191582.1">
        <property type="nucleotide sequence ID" value="NM_001204653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P31319"/>
    <dbReference type="SMR" id="P31319"/>
    <dbReference type="EnsemblMetazoa" id="NM_001204653.1">
        <property type="protein sequence ID" value="NP_001191582.1"/>
        <property type="gene ID" value="LOC100533363"/>
    </dbReference>
    <dbReference type="GeneID" id="100533363"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12097">
        <property type="entry name" value="DD_RI_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000013">
        <property type="entry name" value="cAMP-dependent protein kinase type I regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0114">cAMP</keyword>
    <keyword id="KW-0116">cAMP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000205393" description="cAMP-dependent protein kinase regulatory subunit">
        <location>
            <begin position="2"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dimerization and phosphorylation">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Pseudophosphorylation motif">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="134"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="252"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N-acetylalanine" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="378" mass="42737" checksum="4982603DF922CF71" modified="2007-01-23" version="2">MAANTDEEQSLKECEAYVQKHNIQQLLKECIVQLVVNKPESPLAFLRDHFDRLEKEQVAKEKSKSATPPSDEKEEDMSSTPPQMHPAMNKRMRRGAVSAEVYREEDAAQYVKKVVPKDYKTMAALSKAISKNVLFSHLDDNERSDIFDAMFPVHRHAGEVIIQQGDEGDNFYVIDQGEVDVYVNNVHVTSIGEGGSFGELALIYGTPRAATVKAKTDVKLWGIDRDSYRRILMGSTIRKRKIYEDFLSKVSILENLDKWERLTVADALEPVQFEDKEEIVRQGEPGEDFFIILEGSAAVLQRRSENEEPVEVGRLGPSDYFGEIALLLDRPRAATVVARGPLKCVKLDRARFERVLGPCSDILKRNISQYNSFVSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z085</accession>
    <name>Q7Z085_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">jnk</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2006" name="J. Neurosci." volume="26" first="6439" last="6449">
            <title>Synaptogenesis regulates axotomy-induced activation of c-Jun-activator protein-1 transcription.</title>
            <authorList>
                <person name="Sung Y.J."/>
                <person name="Wu F."/>
                <person name="Schacher S."/>
                <person name="Ambron R.T."/>
            </authorList>
            <dbReference type="PubMed" id="16775131"/>
            <dbReference type="DOI" id="10.1523/JNEUROSCI.1844-06.2006"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="11"/>
    <dbReference type="EMBL" id="AY263405">
        <property type="protein sequence ID" value="AAP42290.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191547.1">
        <property type="nucleotide sequence ID" value="NM_001204618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z085"/>
    <dbReference type="SMR" id="Q7Z085"/>
    <dbReference type="GeneID" id="100533320"/>
    <dbReference type="CTD" id="100533320"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07850">
        <property type="entry name" value="STKc_JNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000009">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000210">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="365"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAP42290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="NP_001191547.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46881" checksum="BD7B3DF859B84EC7" modified="2003-10-01" version="1">MNKLLSQFYTVEVGDSTFTILKRYQHLRPIGSGAQGIVCAACDMLTDTNVAIKKLSRPFQNVTHAKRAYREFVLMKLVNHKNIIGLLNAFTPQKSLDTFQDVYLVMELMDANLCQVIQMDLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTGFMMTPYVVTRYYRAPEVILGMGYKANVDIWSVGCIMAELIRATVMFPGTDHIDQWNKITEQLGTPSQDFMSRLQTTVRNYVENRPKHTGHSFEKLFPDVLFPPDSTEHQGLRAMVARDLLSKMLVIDPEKRISVDEALMHPYINVWYDEREVNGPAPGPYDHAVDEREHSVLEWKMFIYNEVMEYENREREKEKQSAMQNHNDGANNTMETGGAGAESNSTSRGAAATAATAQNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAN3</accession>
    <name>A0ABM0JAN3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101852367 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089302.1">
        <property type="nucleotide sequence ID" value="XM_005089245.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852367"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005089302.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="54327" checksum="1DF783CFBE86B4F4" modified="2025-10-08" version="1">MTHNSPASCMMGSRWGGVKVPAVSLILSIFCVMGAARQLHITRSLGNSDWCLNNAKKVLWISENTSAIITGKSSSSNRRRAKDCQFVFGLASRKENARLVLYFNFLFIHDCGVKLQINESQTGDFTTSKTNHEIYMSQCNTMSPKFLYARPKHYVLVRLTRADVYRENYNFHLNVSMAESLPSTGPALHVVVIVGFVLAVVVLTATCLLFKYMMRLSYRWREQRSEEAMTRAISLYNSQEHTADREPDLVYVEPGNRESQDDHHHSPRNHHTTGPEIAFVHSDGRIERFRTTDRVPSSHSVASVSRNSPRSNRVPRKNASSKFTRGGGSSMSPVMSKPSPKVSRESSSQLSQEPAAIPLLQANTAPTRRSTGDVSEIGLDGGCDMPPSYEEALDMPGPSQLDAALGEEEEDEGDSLFQLEAGADENSVLGCLRIDYVNIGTEPGGEREHVAQDPDGECARGGHDPTATSSLSEPDTSDSGQALVSLPSSRLKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC39</accession>
    <name>A0ABM0JC39_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia-and flagella-associated protein 96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101858321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFAP96 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090247.1">
        <property type="nucleotide sequence ID" value="XM_005090190.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858321"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029358">
        <property type="entry name" value="CFAP96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144:SF1">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15239">
        <property type="entry name" value="CFAP96-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005090247.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34343" checksum="CF3C0D548B94DA61" modified="2025-10-08" version="1">MGDKGGKSDMDRVGLFQEMTYVTIGDKYKPAGQSTFNDAAGKGKQMLPGGSKDKSARQDGYFSEKFNRVMDGEAYSDPVKLRRRYRMAEAKKNLSKAFLPTNGQKAMNGLGTFFGTIGGNVKAFSPVSKGGGSGKNPLKNVMTNPGKRGTGYGYVAVTLGKYPNSENMADPYDNDKQIYRKEVAQHKAQLKAGAFHLNMHPSDYFDGNPYRTDKPLPPLRKSADVTKKDVGPPFRPSNPGKVMGGMKAGTFEPYPLKSKDPYGIKDKRPVNVVNKSGRIFMPSQGPKTTPCKSIVNQNVVRSVNITNYRSVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCT2</accession>
    <name>A0ABM0JCT2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Uncharacterized protein LOC101851621</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10" type="primary">LOC101851621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090740.1">
        <property type="nucleotide sequence ID" value="XM_005090683.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090741.1">
        <property type="nucleotide sequence ID" value="XM_005090684.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827948.1">
        <property type="nucleotide sequence ID" value="XM_035972055.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827950.1">
        <property type="nucleotide sequence ID" value="XM_035972057.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827951.1">
        <property type="nucleotide sequence ID" value="XM_035972058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851621"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="984"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1076"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="918"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="715"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005090740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005090741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035827950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035827951.1"/>
        </source>
    </evidence>
    <sequence length="1199" mass="127461" checksum="3996BD7797A3C920" modified="2025-10-08" version="1">MENPTSPELLVVSSPRVLPTKADLSSEVKDGNVTDGSMSLMNKAPVLIVQHIEQPPEEMGNSSELKVPNGADGDSAVAKAESGGVEEETSPESDDSKKDVDTSKAVTFAEDVEIYDLTSKAAMPITVSLDTPVHLVDHAGLALIAAEVPLEELKKDTASEDLTDSLTAAELETDSSEAEGKSSIAEISDERQSTPATRPSVLSLFKSSSVDKTSEGGGSSLKASENDVATEESKHTSSTTSGSEDQQEEAKVNGEEPTAHKEFTVVSVDESELPASEPQDRTVRAEDTVPLTEVHPLSGKTNGQSHSTDSFLHDTIGPLDNPAFLKTLHYSVSQPFDEDEHFGLQSNLDLHSVTTLQNTTSDLDGGWAWVVLCAAFLAQTIIGGSVYASGVLISAIVEEIDPDLTKASWVGSVFVCAQCLTGPFVGAALKKFGARIIVSLAGVVFTLGFLGASFSTTVGQLILTHGLIAGVGAGFILNPVFVIVGQYFCRYRGLACGLLATGAGAGMLTGGAIVSLLVRTYGLSGAYMLWSGVVFHLTAIGMLFRPSPEERFRQIEHEIRVKSSLNRQGSQQELTSGHNSMMSGLNSLFGSVNHSMMSGMDKISHGRRSVVSRNTSKLSNGEIDMPLLKAVLHKEMSRSSYSVSTNRSHHRSHVTSPTQTTSTSSKHQQLAPGTVGHGESNQLLSVNTEMNGTPTPTSPMNAISNGHLHTATSINSSHALGSSNHHLSNNVNSNGSVQHLNNNINSNSSSQLPLHHSSSQFFSTSTLTPSVTASSRLPPPSPTSTHGASTSLLNKPPPHRGRLLSAGSQSQYTSMSHISRRLSLRDHSHTGEYDNESLSSTLISQLRPRDAIAPRYALGSRSISTMMGSVASFPTSLAIIKDDLSRFEAYSSTTSHRRSLTGFAIQVLDSLRLLRNRPFLIFLLSNFMWAFGESPIMIYLPSYAVSKGTDKMQASFLYTSMGIGSMIGRLLSGLVAGDKDVGPVLLFTGSLGVAGMFVALSPAITSTMMEQVVVSCLLGLYTGALVPLTSLITIDLLGIGELGIGFGFLLMSQGLGYLIGPPLAGMIVKELGFARSFLFAGFLLMGASLFSMIMALFLGKQEDELDDDDHSLDDLERALQRISDSESDNSDEENDDKGGCGEERDDLGKGSASNISRLEGSTHGVADFIVSHSEGGGAEKEEEPVPVEEERLEPIMEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDE8</accession>
    <name>A0ABM0JDE8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Rho-related BTB domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8" type="primary">LOC101857853</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091128.1">
        <property type="nucleotide sequence ID" value="XM_005091071.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091132.1">
        <property type="nucleotide sequence ID" value="XM_005091075.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828874.1">
        <property type="nucleotide sequence ID" value="XM_035972981.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828876.1">
        <property type="nucleotide sequence ID" value="XM_035972983.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857853"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18499">
        <property type="entry name" value="BACK_RHOBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="487"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005091128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005091132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035828874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828876.1"/>
        </source>
    </evidence>
    <sequence length="708" mass="81313" checksum="2709C789E3E4993C" modified="2025-10-08" version="1">MVNQSLTGFEEVIKCVIVGDSGVGKTCLSCAYACNAQYNLQKLVKTHQATVWATDHYQHDREILDRSWCDIDGCQVSIRLWDTFGYHDKDRRFAYRGADVIVLCFSVMSPVSLKNVHRIWHPEIRRFSPGIPIVLCGTQADLRYMCHDENYLSMEKGLLYRHISPEDLITPSVGREVARDISAPYYETSVLTHFGVQDVFINAARAALLERRKIKFWNTQLRRIQRPLLQPPMKMPIPTVPRIQIAKPLLKSDISALLTNKSECDVTFLVGHETIEAHRICLTVASTFFQDLFSLESLAKLPARRRRKNSHLRRQFPKRFSHTDSEFLLDSDQESLSTDTDYDSSVQGSAGDSYLANNSTSGSRLRLPLIIPYDHRAVELIEIRYEEDAVDPSHRCLQTYVRMCEEISARSFHVVIEYLYTGSLRPCEVNLAQVRKTADLLQLTDLVVVIDNVLSSQDFLNIEMDKQFHEKRIFKLRELALHKDFLSDITFEVDNGLVSAHKALLMGRCEMMYAMFSSDFIESASDVIPFPGITEETFQALQEYLYTGESPNMDSVDCLALIEVANRLCLQRLVNMVEARVVTQLAACEDTGELLTDALTLIQPAELYNASQLSHFCQHILCVNFQEVVQKYASLFHALPQDKQEAIEQKRWPPVWYLKELERYDRLTQSHSLHGTRHAVQDYNSRCGCLCFSRRRRHRLIDPVELPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE41</accession>
    <name>A0ABM0JE41_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit alpha-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101858603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091588.1">
        <property type="nucleotide sequence ID" value="XM_005091531.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858603"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005091588.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="42078" checksum="DD977375F0677B84" modified="2025-10-08" version="1">MADMVMSCCISEHEKTQRIRSREIDKKLNRDRLTFRRTVRVLLLGAGESGKSTFLKQMRIIHGQDFDDEAVREFRTVVYNNIVKGMRVLIDARQKLNIPWGDEACTKDATKVFNFNSNSKLDDTVFCDYVESLKTLWKDSGILTAFDRRREFQLGDSLKYFLDSLDRIGTVSYVPSRQDILLARKATKGIIEHQIMIKGVPFMFIDVGGQRSQRQKWFQCFEGITSILFLASASEFDQVLMEDRKTNRLMESCNIFETIINNRNFAAVSIILFLNKMDLLQEKVALVNISDYFPEYRGDPHSLDEVKHFLCQMFDQRRRERSKPLFHHFTTAIDTENIKHVFQDVKDTILHDNLRSLMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE63</accession>
    <name>A0ABM0JE63_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091640.1">
        <property type="nucleotide sequence ID" value="XM_005091583.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850135"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF4">
        <property type="entry name" value="SI:DKEY-5I3.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047202146" evidence="1">
        <location>
            <begin position="22"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091640.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38322" checksum="FC673EFC077342D2" modified="2025-10-08" version="1">MILRMLYIILRLRMMSTKSTAVMRLVPVRTLSSMAKEPKKLETKTSTFELSDRHQLHVAKSRESWQWKTDPTKVLVLFFPWLGSKEKHVQKYRDLYLSRGLDVLTVKSVVSDFLWPPKAQKFGKQTMEVLAEHCNNYEHFLLHTMSVGAYNMTVLRMLAAGENDPSGILRRCRGLIYDSIVGGSGKGGVVQGSDAAEVDKKPVHATNRMLHGIAVSASKNRVVQLTIKGVGKMYLFFTKKNTVAFYDKSLTVVRDEPLPVPTLMYASRNDPMVDAYVVEQLAHIWRTSKGVPVEVKLWDVSGHAQHLVKHTEEYVETLDKFLSDIFSESLPSLPGASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEK4</accession>
    <name>A0ABM0JEK4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="13">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101859765</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_005091940.1">
        <property type="nucleotide sequence ID" value="XM_005091883.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859765"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="982"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1041"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1142"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1231"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="350"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="657"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="1000"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="1320"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="936"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="936"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005091940.1"/>
        </source>
    </evidence>
    <sequence length="1559" mass="175418" checksum="430C444D90C20C2E" modified="2025-10-08" version="1">MFPDNDDFCHGIAFWNESLLLDNWYPEFTSCFQETALTFVPCGFLWLSSLVLLAYLKGHTKYVVLSWNWRSLSRVICALVLSVLALLHLTLGDEETEHEGMMASPAFYVSKAVWGVTFLYAIVLMGLCQRSGVTSPCIIFIFWIIAIVAHVVPVYTSILKKSYEEHLRSFTLVCCELAALVFGMAFLWIGDSDVVLTKPSITGTPCPSVSASYVSRLTYAWVFSMVYSGYKKPVTADCEFDLPPHMQCRNIYPGFIKSWTKELTRSRAVNRTQEKGSRHIYTNGATSLLGSVQKGDEVEHNEKTPLLSKMKIDGEKEEEVQAKWPQKKPSLYKVLFKVFYLSLFKSQMVGLMADMLQFVNPLLLKAMINFAENKESYPQWQGYVMAGSLFLVTLSISVMTNFRFYTAWNIGTQIKTVVTAAVYKKAMTMNAEGRRQFTVGTMVNLMAVDCPRFQDVSLQMYVIWSFPIQMSLAMYMIYDCLGLAFVACLGLLLLLIPINAKITTLTKRAQDKQITIKDTRIKLMNEILNGIRVLKLYAWERSFEDKIGDVRKLEVLQLKWAAIYQSLSVLCWLLSPVMVTLTAFIAYVVISGDSLTPTKAFVAMSVLNIIRQPMMALPQLVAAAVQCHVSMERIRNYLAGEDLEEPDPTVASPEYPLTMESGTFCWDRYLPPTLKNVNVRVGQGQLVAVVGAVGSGKSSLLSAFLGEMERLRGRAGVKGTVAYVPQQAWIQNLTLRDNILFEKPMNQAWYKKCIQACALGPDIELLPGGEMTEIGEKGINLSGGQKQRISLTRAVYQQSDVYLLDDPLSAVDAHVGKHIFDNVIGPQGVLKNKTRLLVSHGLHWLPRVDSIIVLDDGCVTETGSFDQLMDHDGPFAQFIRTYLLEHQGEEIDDPEELMVREKILDKVEAITSDDEQGQISLRRSVSVLSDTVKSNKTASTESLNKPNEASRSAAEVSGKRDQAGRQLIKEERQERGKVRLSVFIAILKAFGYLPASTIPFFLVVFIGFNVGTGIWLSKWTDDPYLRNETNVGTARYMDDTYYYLGLYIFFSLMQIVGNSAYILVLVIQFVNASRRMHNKMLKTILHQPMAFFDTTPLGRVLNRFSADVDQMDSAMSRLMRMVLQAFCNIIAILIVISYTAPIFLAVVIPMAFIYYLAQKFYMPSSRQFRRLESVTRSPIFSHFAESISGASSIRSYKVTERFSLDSQKRVDTNNFWFYITSSAMRWLRIRLEILGNCIVLFAGLFAVISDGISGSLVGLSITYALQVTGTLNVMIQNWTQLETRSVSAERILEYSELPYEPDWVVDSSRPPLDWPERGEIRFKHYSTRYRPGLDLVLNDLDFTVKPGEKVGVVGRTGAGKSSMSMALFRVIEAAAGRIVIDGVDISSIGLHDLRDRLTILPQDPVLFSSTLRFNLDPFDMHSDVEIWEALRHAHLVEYVMGLPAGLEHICEEGGQNLSVGQRQLVCLARALLRNSQVLVLDEATAAVDLETDALLQAAIRTALDNRTLITVAHRLQTIIDYDRILVLHEGRIKEYDTPKNLLDNKNSIFYGMAKESGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEM9</accession>
    <name>A0ABM0JEM9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101853525 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091997.1">
        <property type="nucleotide sequence ID" value="XM_005091940.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853525"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047396612" evidence="3">
        <location>
            <begin position="24"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005091997.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="58841" checksum="428DFB773DFD3DAB" modified="2025-10-08" version="1">MRLNQVSSFMCSLTALLFDYVLNTHIQEVSVQVDKSKKSCSKDTIMKDPSTVYYTSAAPRKEGSDCSFHFIKECSLKFSGDDHVMREAYKICFDLSNQTVDDCLSQVKFSKHMANGLEREIQGIYCGSGKLSLLYPRSVCLGSGENLTVAYMSTNFCNFRGFVKVYVKKIWPHTYDLREVAINCPEGWRNVRSTRGVVVSVVNKPNVKHPVLCKLHILPESDVQKYEKFCFIFSVAEFSMNSVQLFIEGSALEQFGFESVPELGTEYCIALAPSFDYISIEVSPGEDRYASPANVTNYQHSFMFKYRFIEKVKSTNVGSTKEEKDDGYSKNTLFVFFSAPVALLLILYLAFCTRKKRPRTLSNAGLAKDFPPGPYYTADPFDLHGRKLGSIRLQRAVELLENTTTAEIAIAQSSGMLPTPSPQDDELTQVTRVSAEVTPQTPVRASNSLQNEQNTMNKEDIPLASSLGAQSSLATSETLKDCTDRTEEQPSVDTNVVEDEKFPLTDSASCRPPPPGYNSLFSKHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEW8</accession>
    <name>A0ABM0JEW8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101845904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092140.1">
        <property type="nucleotide sequence ID" value="XM_005092083.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845904"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF7">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092140.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="33394" checksum="28CA6A03D3915150" modified="2025-10-08" version="1">MSLKKETPSDQQLHLAALQGNLDQLKKTLDSGRVHVDCKDKEGTTPLILAAANNNLSCVKELLEQGADPNARRLTGTCALFFAAQGGFIDVVKILLEHSANVDLASFDGGTPLFVACQCNHQDVVAELLAGGADVHAQMIDGATSLFITAQNGHADLLDFLIAKGADPNLKRKDLASPLWIAAQMGHTSAVRTLLNAGAQVDAVREDGATPLFKACHKGHLDTISELLKHKPELGVLKNGETVLHAAALFGHLKAVRILLRAGVNKEVKNKEGQTASDLATEAGYDFISSYITSFDKSKDELDGQSLDASVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFS5</accession>
    <name>A0ABM0JFS5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101854150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092693.1">
        <property type="nucleotide sequence ID" value="XM_005092636.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854150"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="7">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005092693.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15655" checksum="314B3317E00247E9" modified="2025-10-08" version="1">MDTQRSPHTKVFIQRDFSEGIPVKFQTRYPPELEGRVDRATYESTINTINEMFAEAESTGSRTYCESCFACLTAYLALMCMDTFYEKTLKKVRRYLEEQNQRIYMSRGVMIIDPAERGLRILEIDISSIDTPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH07</accession>
    <name>A0ABM0JH07_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101856498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005093482.1">
        <property type="nucleotide sequence ID" value="XM_005093425.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856498"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044963908" description="Carboxylic ester hydrolase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="40"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005093482.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="63755" checksum="4ED336D54BBBFBF4" modified="2025-10-08" version="1">MGRILVMECNSIFFLLCFFGHVMVSLSRVGPFASAGHLGEPQVSTSYGTVQGKTVQLDSSTYIDVFRGIPHAKPPIGHLRLKKPEPPLPWKGMKNVGRDNAMCVQNMHPVTGETEDCLYLDVYRPRLTNSSQSLPVMVWIHGGGFRHGSKNSFNGSILASHDVIVVIVNYRLGPLGFLSTEDDVIPGNFGMLDQISGLKWVQSNIAAFGGDPKSVTIFGESAGSASVSLLVLSPLASGLFARAIMQSGVSSTSRAVPPPGVLVSPKQIAMAAGSKLGCHQQPGVAFLSCLQRQSVQDLFNASIKAGYSDHSSSSFRPRVETVFGFMPEYPLNLISRGHFSHVDTLRGFNAQEQGKTVSDPENDGLTREEFRKACRTQLRDFPYLDIDKYVQLMEDVYLTNVTDPVEIRSKTIEMRSDFTFIGPIVRETQVSRKHNHESKYFLYQFNYRASFVKTPEWTGVLHAADNPFVFGLSSNLAGTWHRKTTAADEEMARVMTTMWTNFAKFSNPTPHGSTQLPLVHWNQFFNNRPSYLLIDSHLQNKKFDTAENVKMLNLYESTEKEYIHALAAGNTPIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKA1</accession>
    <name>A0ABM0JKA1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 316</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095688.1">
        <property type="nucleotide sequence ID" value="XM_005095631.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861353"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="889"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="918"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="946"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="974"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="828"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005095688.1"/>
        </source>
    </evidence>
    <sequence length="1064" mass="113170" checksum="8938C363548C86B4" modified="2025-10-08" version="1">MATLECNNTQDSYPTENGDSLPEEKSLSIDYSEDLWLANEDSSGPYAQQPNKVTSGDGVVVTNVPSSQPESMASYPNSVEAAHASEVLATSDGDGQSFQEGVPVVVEAGTVVVGGGESRPLEPAANFLNGGTVEQNGTDYNGGAGHESKEFVQLVPAGSFVEGAGGAAVVVGGGEGQDKTFTALMPAAGLGVNGEVPQGFSTMLAAGHPHMVFYGSGETLASDGGQAAVMSHEALTYAPQAAAVAGGDDDGGSSSVRYEQAAQMAEGEGEVVDSKDGIYVAVDNLSSENQSVAVSGNFTVLNPAMMSAAPPGVEGQTFANATSSGSGGAATYHNISTLPFVQNGTFSTQPGYSAAFDPAGTTIITTSNSSSHSNGVLVTHNNNNINNGVVVPSAEYVDGQQSSSSSYAAGGEGGSQVKMEELDPAAVDDDEGEEEEEDGSGAELGEGMEMSEFMCPVCNDPFPDQASLDEHVANHPPPKTFVCQTCGKGFATRRYLKYHRKNHCKRAGSYEGRGDLDETDPNGEVRRFTCNVCSRPFRVLKCMKVHKKKKHGILKEFTCHNCTVTFNSSQELISHPCKPQPARAVMDVATATTSAPVQASPPPLAFPGPRKKKKLRQAKPACDICGKVFADRISVDIHRVKHIEEELYPCDMCETCPEGSDNHHLAVYFRIKFFTDDNQHILEDQKAAVASTDPSRPEESTAGTTPSHTPGTPMQGSATPLSAPATPIYLPATPGGQGQGPGTPASVNVLNPADGRVEVVDGQLLDQYSQYGSHLAAGASGGDQVVNNYLLKQYVLPEGGEATATISAAAEQQQQQQQQQTVLIGHQPQGQPGLVVHQHHHHQQQQQHVYVGESSGGGGGGGAASAGNESLDGSIAGSAEKKKKRSKTHTCDICNKSFGDSAKLELHYKSNHLEDRPFQCDVCDKSFFTKWKLQRHMLSHLEQKPHSCPMCSKSFVERGKLDAHYRTHLGTKPFKCEHCHKAFTVKSQLTIHVRRIHSTDQPFACLECGKAFLWKSGLDKHMRKHTREKPYSCHCGQRYSNKSNLILHMSKVHNETHVDAQAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKI4</accession>
    <name>A0ABM0JKI4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101861574</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101861574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095863.1">
        <property type="nucleotide sequence ID" value="XM_005095806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861574"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005095863.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17956" checksum="B538056B4DDAF797" modified="2025-10-08" version="1">MSSKIENYADSDSEIRSVIRFLAAKNRKLNDTHSTHISEVYGEKAMGESMVRKWVRVFKQGRDNVLDEPRSGCPSLISDDLMNKVDIKVKEDERFTLSWLSSNFPEISRSLLLEIVTDHLGYRKVCSRWVPKQLTQAQQDQRAASALAFLTTRYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLX3</accession>
    <name>A0ABM0JLX3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101850557</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101850557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096753.2">
        <property type="nucleotide sequence ID" value="XM_005096696.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936990.1">
        <property type="nucleotide sequence ID" value="XM_013081536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850557"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005096753.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012936990.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14177" checksum="ACD51B4095C11B85" modified="2025-10-08" version="1">MVWVELPADLEFGCEAVGVACILDCASRFAGTELYRHGFSSPGPLADAEDNLKEDPSARAEDDLTQRIPRPDHQQEDPSAGAEDDLDNDAFDTTDGPDHQQEDPSAEAEDGPDNDAMDTTAGPSTGGPLCWSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMN4</accession>
    <name>A0ABM0JMN4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101853784 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097268.1">
        <property type="nucleotide sequence ID" value="XM_005097211.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853784"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047004636" evidence="3">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005097268.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17404" checksum="E59B5F42699EDE2F" modified="2025-10-08" version="1">MATVTIASLFILVFFVNYGEAILCHRCMSSMGGCGDSVVWRMYPWKDCGDSFCVKVIEKVPGEEPRYIRECERNLLKSTRHRLRMPVLRRHGYCVPARKNDPFNPLDSIDSRFTYCFCNDWNGCNTAVSNTVSKVMMFALGGLATFFAYRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNU1</accession>
    <name>A0ABM0JNU1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098045.1">
        <property type="nucleotide sequence ID" value="XM_005097988.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855252"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1496"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1818"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098045.1"/>
        </source>
    </evidence>
    <sequence length="2181" mass="237534" checksum="9D4867F4C157FD6D" modified="2025-10-08" version="1">MDNEEQILQMLEKKQDLFRRHKKSQKPKRCTNVTALHKLRCSDLDSRSVINNRHVQQFVTEQEFRSSPHLPAPPIKCGIDTTFQDNKQNDLKPSGGVAPTSTNSGRIIHGGGREKKDSKSAIVSVDPSSQDGKVNTRHSRTPLASKKELINRSSTVKTMSKVTVEEKSFLKDAELTQKQNSCVDNKVEIEDEERGFFFYSTPENPENKQATTSGKLPGPKGDNLDGEGESSEEDVIEATQVCSVKTKFASSVGRRQNHVDVSESGRRRGPRSLLTVSPPGSLSIKSSLSFGSAVDSLACSSTDQKSHHLITDSQFFQMLGVSDSEQGESYLDTMHCDKASNPIESNNSALVQFEKQTSDRTHAFGSQSNTNDFCQKTSFSVDSQNGQSRLMVDTQDVENRSSINSPSCSIESWLDENTSKVISKKCESTLDSLLDQNTSKVISQKCETKVDCNNDMISMSPIGCRNRLKTCTTDTQNDQSRSSFDSQDGEKSTIDFQNDQRKSAVCLQNPTSSETILSLKNASLSYIPLEQKLSPSSESSELMLKALSTNASSPQESLLYAYPTTVPDTEMPVSEMPYSNFTELDAIPYSQFELSEDFLSNEIPFQNFKGVKARKKSISLVKRRSPRIASQSYSGNNSAGIQSSNVSRATPKSTCTSQMSHRQAGSKAGTQGGSAWRTKKAQAIFAIFQVLIEEMKKIPSSEFELPDVYRSLQSNTDTGEKYLESQPEVVPSNVSLDNVPTSALEEGRSAALSHKTAEGNWKTYHPDEVKPSNYLLNFKNVDQTKVDLDDGMSVQCSGSSKSNNALVRATGSAAIRRGSVAGDPVDFTDCIPESEVDTIEDSEPTESSGLMHTGKSDVTYIVKYNATQTVVSDRHTKKYNSIRKEKSDSTLSVISDDTLITKFDKSELKPPGRSNLMETRQSDESDKGNCKVMGAKKSEVKSVSESDVTGTERFDQVLLKQSCTNGKSEFDGPLTVKSHVKRCENFEVTDSAQSYMAPRKKSSNSEKLLDNTTLSMKAYGKQKVICDQIVGPVRLAPEGNAEPTVILESPLAKSQKGVTNSHMVRSSSNMDVQKMMEGNDVVQKLPVSPLQSGEQNKKQTLEQDLGRNVKGDATRTSASLGDILLESELKEKFMCNPDSVLSQRRIDTPDFPSTPRRRKSKKLRHSLSLNRRLFSRSVVTASADHSPKDKVCSDNYPGVESEKEKTVEDVKYAGNSPGERDCVIVQHCSEEMGAKEKPCSDVSPKAKRRRRNMIENARPSTEEPDADDNVHLSSGENAKVLPPALTLCCENENVESSSTLINETEVMDTSGEGVRVGAANFNGFPFENIEVVNTTSVCSVRDKRDNADVRATYCSPVRVPESSVVRGVDHNFSLTSAADVVRQNTDNVMLNSEADDREHTDSCRVSTVRQNINNVNFPASDLNLIHDKVLVAAECDDIRNVASKQEDNAGCVSFTTGQGLCPSNCHLSPVASSPGVLSQSMCEIVSIGVPMTPSAVGHSVGSLPPSPQTPVTPIISSARRKPTPSVKSHQRFSFTSTPKTNIKQNSLSGLPLESPCSATDYSATLGVENRTINDRNELLCDAIEQGPASTTCSSASKVPQHKCLTETVSVHAPPTLASPTGTSVDNNDEVKPIHHHDGCASLTDRSPLGVAVRTCQVNTSVCEESYVSPGQTLACGSPVVTSCCHGQVKSILHEESYVSPGQPPKCASLGVDQRNNKSCEEKTAHHDESYVSPAQPPQCKTPRGTMISMAQSETPNFEESYVMCPGQPVMSSSSVVTPAGDSQEKMSQQCVMNKGRKLNATPSGLTYIWEEGSSGPRHGSFVFTPGRRKSRSGDRRGKSNKPSKTLKFSGCFQSCSQDAVVRLLCGEVILPDGQSQPYVVSVQATALTIWAQTDQEQWAAELDWALSQASHILSSCLLPAKDSVVVVTSGRLSGQPCSDVFVYHWTSETTSRFSLPLAEEYPELSEPSAVLLCPVSESSLHLGMTTMNQYAVRNVSITTPGHCLRETTVSRPCRGQLLDLVVISGESSAALLGLTADQRLLLWNATLGVELKRINVSSSLPCLTRLLAARSCEGVLILDVAWRSEEADWGSSVALNPMSGQMVTLKTYDTPDNMWKRLEELRSEMGFVTAVNDRGSVAIWSQVTGGLLGWVRSGQTTSVAVMGSSLVLGEIHGCLHLYTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPH0</accession>
    <name>A0ABM0JPH0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101858027</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005098486.1">
        <property type="nucleotide sequence ID" value="XM_005098429.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858027"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045006962" description="Metalloendopeptidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="11">
        <location>
            <begin position="94"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005098486.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53510" checksum="5037D86447A1CD6D" modified="2025-10-08" version="1">MNRHRWAFGFYGVLATFAFLKSGEAMTSDKQIVNSATHPSTFNFFHLMPGGDVELTVEYDVLLSLEEYRVLHGSGADSTGRLNKRKAARPMHPRGLFLRWKKCVVYYEIDPSLDAGTERIIREAMDEWEKYTCLVFKMNTSITHRIQFKDGDGCKSKIGMQKKPQPLLLARGCRTKGIIAHEIGHAIGFFHEHMRPDRDEFIHVNFDVIKDRFKPDFKKYSTNYIETHGTPYDYTSLMHYGNVIPGSILTLDPKFQDRIGQREGLSFQDIALANKMYNCSKMFCKDPDQCPKGGFKLSLSLKGKMKCQCWCDSGDLKDPLVLCSERTKVPPSPRPVIPSKPPPTVSKPCFDLRQDCAYLKEEGKCMSSMELMMDYCAKTCKFCGKGEGMCMDHEKSCPLAASAGLCIDPGFKHYIRVMCPGSCGLCEKPPNPCHIQQEMMGSDFALASRNRAGRAGYMPRVLALSMGLLGLALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQE4</accession>
    <name>A0ABM0JQE4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="26">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC101862272</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25 26">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="25">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 25 26">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="26"/>
    <dbReference type="RefSeq" id="XP_005099109.1">
        <property type="nucleotide sequence ID" value="XM_005099052.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862272"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="25" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 25 26" id="KW-0274">FAD</keyword>
    <keyword evidence="5 25 26" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 25 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="25 26 29" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 25" id="KW-0521">NADP</keyword>
    <keyword evidence="11 25 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_005099109.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="60686" checksum="F91481210BD7DB28" modified="2025-10-08" version="1">MAASAKKVAIIGAGASGITAIKCCLDEGLEPVCLERSEEVGGLWRYTDTPVEGQGCVMKSTVINTSKEMMAYSDYPIPEKCSNFMHNTEVFEYFKDYVEHFGLRKHIRFNTSVLSVKKTENFPVSGQWEVRSKDDKSGEEKTEVFDGVLVCSGHHADKYVPTFPGLSDFKGKVVHSHDYKVPDEFADKRVVIIGIGNSGGDIAVELSRRSKQVFLSTRRGTWILHRVAPQGKPLDMVALNRFVMFLIQTFPTLFGMILEYQLNQKIDHKLYSLRPSYGPAAQHPLVNDDMPNRIICGSIKIKTDIKRFTATGVEFVDGTSEEDIDAVILATGYSFGFPFIDKEVIDVQENRVQLFKYMYPPDLERPTLAVIGCFQPLGAIMPISEMQCRVATRVIKGEAFLPPKSEMWEDIRAKEAEMAKRYTKSRRHTIQVNYSPFMDELGEIIGCKPDLYQLFRHDPVLGFKVAFGPITPYQYRLKGPLAWKGARKAIMTQWDRVSAPLKTRPLPIPDSGTGNNRQLMMIGVLILLVFIFRYLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQV2</accession>
    <name>A0ABM0JQV2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] reductase FabG isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099415.1">
        <property type="nucleotide sequence ID" value="XM_005099358.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854087"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099415.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="27765" checksum="F2EC417F111ADB04" modified="2025-10-08" version="1">MAAAGLTRSLSGKVALITGASSGIGAATAVLFSKLGASLALTGRKEGNLAKTGEECAKNSEVKPLLITGDLGKEDDVQRVVDETIKHFGQLNILVNSAGIIELGSIENTSLDQYDKMFQCNVRSVYHLTMLCTPHLVASKGNIVNVSSVNGLRSFPGVLAYNMSKASIDQMTRCVALELAPKEVRCNGVNPGVIVTELQKRGGLSDEAYATFLERCKMTHALGRPGQPDEVARTIAFLASDEASFITGASLPVDGGRHAMCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRC4</accession>
    <name>A0ABM0JRC4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein kinase PknK-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099732.1">
        <property type="nucleotide sequence ID" value="XM_005099675.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850249"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099732.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31308" checksum="6D5E9D64462ED06A" modified="2025-10-08" version="1">MSSVEKIRVIKLHKGGDVFHYHRIHYLSVLHQGQRSKILLARSNKIPDRKFAIKQMPLVSDEDRDRFTREMYLMKLASDICGVVTLLSHPVFCGPIGYLIMPFYEKRDLLSQTGKLSHDSWMKVFVRMAVSLRSLHKKRIYHQDLRPQNIVLTDSDVAFISDFGSAYLLPEGCDKVDTWTAAPGFRGPEADQEGGQFCPFQLDTYSLAVSMWQVLSGLCPVKYKPLDHLDNIPPKYAVLLRNLLLQDLDRRWTLDKFLSEALELHPDLSCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRK4</accession>
    <name>A0ABM0JRK4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Marginal zone B- and B1-cell-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099898.1">
        <property type="nucleotide sequence ID" value="XM_005099841.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850958"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052682">
        <property type="entry name" value="MZB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15881">
        <property type="entry name" value="MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15881:SF2">
        <property type="entry name" value="MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3456" evidence="1">
        <location>
            <begin position="101"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099898.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24099" checksum="36EA646031DD268C" modified="2025-10-08" version="1">MAAYLLSQLVQARISIIVLLACSFNVVWSGENEKLREAMMNSARAQGIDPDNLKPGQMLMTPPDMSDEEEGSQFMPKIHRCDGCRAVAYQLEKNAFPSAERKKKKGQKLGDSEILDVTENLCNNGFHRQYGLKNVKGKNVLSGEGLESADEPGMMEAGGRWQARLQNLCKELIEEYEEDGIYEMYTERGEHKLELPLCSSYCKGADRKKLQDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRM8</accession>
    <name>A0ABM0JRM8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tonsoku-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101864527</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tonsoku family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099958.1">
        <property type="nucleotide sequence ID" value="XM_005099901.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864527"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="448"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="668"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="889"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1010"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="889"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="942"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1010"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1032"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1065"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005099958.1"/>
        </source>
    </evidence>
    <sequence length="1549" mass="172913" checksum="5A9CDD0A7B627D5D" modified="2025-10-08" version="1">MDDEDVKELNRYQKDKKKAEARGKLGNVAELCNCIGELYSKYGKYEEAIQEHEQERHLCQAIGDRIGEAVACRKIGECHCSLGAYAEALFLQKRHLTLARECQNHLEEQRAWATIGRTYLHQAESQDSVQSAGASKKAERAFAQALEVCEKVKDSLKLPEYMAMKCRLYMNLGVVFDARGESAQSGDVMKRAVLIAEKFKLDDELYMCQETLANMYQKGENYSLALRSLEVALRLSRKLRNKVGERESLVQKALIHVSTGDLLAAKHSLKQAHRLRIDSAVNEVKLIKVFKSVNKIQDACQDLETESDDRKLGKLHEVIADNFVELGLYNKAVEHYIHVLEWAHLMSSEERAAIYVSVAQTYADLRQFDNALYYYQRELEEWGDNQEQACRTYLNMADLEEKKGSKYGVTGKLYMSAFEAARKAKHRKLQIQSLEALIAVQKIHKQATHQQETEKKLAMVQRKKAQEDKSLNEEDSSMDEEEEEKEENKGDLSISDLTVSEDSDEGGPSFVESGRPKKSNIARKNEKGETPLHRACIAGNLKKVKTLISQGHPVNPRDYCGWLPLHEACNYGYRDIVEYLLDCGAWMNDRGDVDCEGLTPLMDAANCGNFDVVSLLVDRGANVLAKDDHGNTALDRLRSWHGATDDVLSAADTLEYQRVQALLLRKMGRSEQDSSGTPTSGFTAHSVNEEHNLSKKVHVGSKPTTSGMRTKPKSFRLPDLEDTDSSEEDVALLRSPPKKTLSRKKPVASTKRKNPIEDETVQMEDFSDDGDFIFPLSPAQDDPSTNPTEAYRSAICAIASSAPKRLEADFTQTDKKSDSSSNAQTKRTALLAEDEVGDDWLIEDLKAPKLKRKSTAVKEILTTTSTRATVAGYTKRRKVTDKASKFSELVRRRQKAKSDGREGRRRPSFVDSDEEGSLDGNSRSSDVVSSSGIPLEEEETLEPEHTEQYNIQDEKENYVWDSDDDILCEIDPVFDYSLSASQSDVSTLPEANRPSDITVTNEPSIRIPVSQHTSTENSSVRFTESHLVQKSSNRENSHIDRRHSFSSIRNEDGDTHASWKHNSERSCGQPRQDTLYTQRMSPAMAKEVTPERRSDPVARPVLRFKVQVEDKTLLIPLQASDSDKNISWLAREVGERYFSMYLQRPALALSTSDGILLCPVDPISSVVADNDHLKATVTLWERPQLEERYAKACQMFCTEANHSVSVRLHDCEASGQLSLSDLGLGQQQLQPVYRALEGQTTLTNLSLAGNRLGDAGLVPLTELLQDMPNLKSLNLETNGFSSKGLCTLSKALKNGCLQSLQHLNLSHNCLGDSAAEWLTNILRDLISLTDFSVAACSLSAKVFTPSFCDALRGRSLKRLIFAENQICDEGIALLLSNLHADSLLALDLSHTRSESTAELSEKLQTFIASDEKCSLTELNLSGCHLVANDVLFLNRLVAEVSSLQKLSISQNQQVTCSSLQKLLYLSAYRGSGMEELTARGCSITAPLSSEFLAAFKEKMRSARPLRKFVFTCRGLGKVEVESIHGMWTSVWGEEAVVKVLGPSVSLSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS23</accession>
    <name>A0ABM0JS23_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyltransferase</fullName>
            <ecNumber evidence="14">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101847661</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_005100228.1">
        <property type="nucleotide sequence ID" value="XM_005100171.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847661"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005100228.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38808" checksum="61CBA228F7F95065" modified="2025-10-08" version="1">MKVLGVEFAPLSIPTERRLQTVGALHYTFCFLFFGFGMLFFFIYLFLFTSYYFVPLAYLLWYYYDQSVSEQGGRRSNWVRSWSLFRYSAKYFPLELIKTQELHPSKNYIFACHPHGVMSQSHFVNFATEGTGFSNVFPGIRPYLCVLSGQFMFPVFRDYFLLSGAVEVSRKSIEWVLSKEGCGNAVAIMIGGAVEALEAHPGSCTLKIKSRKGFCRMALQHGASIVPVYAFGENDLYDQVPNPQGSRVRRFQNFLTHMLGFSPALFHGRGVFNYTFGLLPYRKPVHTVVGAPMDVPRVEEPSQEQVNQLHDDYCKALVDLFESHKLKYGVSEEQHLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSQ3</accession>
    <name>A0ABM0JSQ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B-cell CLL/lymphoma 7 protein family member B-B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCL7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100627.1">
        <property type="nucleotide sequence ID" value="XM_005100570.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859942"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006804">
        <property type="entry name" value="BCL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767">
        <property type="entry name" value="BCL7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767:SF9">
        <property type="entry name" value="BCL7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04714">
        <property type="entry name" value="BCL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100627.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26160" checksum="B61CDED35D7CAFB2" modified="2025-10-08" version="1">MLSRSGRAETRSRAKEDIKRVINAIDRVRKWEKKWVTIGDTSVTVLKWVPITAQENPGALRKVPGVKTKTYSKARVEKERELYTDSLSQAEADAQLRAGSPSNSNTNLSSASSPSSKTQHSNGDKHKSGVVRNSSGSVVYTEETTQQSVGSYCSENLNEDSNMSFPDQSENSPHNENTNEFSHDSNDVYPEMRVAMSMVREEESGKPDPPEESNDGGPPELEPESDEPLAKKQRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSS8</accession>
    <name>A0ABM0JSS8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-rich adhesin for platelets</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101848977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100667.1">
        <property type="nucleotide sequence ID" value="XM_005100610.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848977"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100667.1"/>
        </source>
    </evidence>
    <sequence length="1043" mass="110569" checksum="4BD85EF9A2116D05" modified="2025-10-08" version="1">MDPFGISEFDDLSSTPTDTTTTTKSALDEFDVIFGTGSVPSGGGGAAGSSASSEPPKLSETKGHNLLFSLDEGDSSTTSGAFPASSSSSADTAATAVDLFSGLDEARRAEDSVTTRDLFDDLLDFTPSSGPGTQAFGDGQGTNGFSATEVDLLSGLGNSTSDSVDVPPPQVTKGPPDLLDFFDDVSADLPEVSSFTTPSDNQTDETDGPVSVVKSSPEVSAETESFPDILVSTPSVDVNDGVMEGKTVEVSEEEKMDGKGEKEMVDGKENREIVQMETQAPYNPDQDMLDFSVVAIPDSSQLNFDLSKHKRLLSKKGSIARRKKPSRAAILAGNENSEENRFNDSTEPRPAKPPAEDKEEEKTAVVEPEPEPNKPEEAEPVIKKFAGGVKIPGLLEGLTKSRSFKRAERKHSPERNESSVPGFPAQAAMKPPSPVVPVTADNSVSGLASSCGSAPAPAPALAPTPAVRPKPVALPRVLPKTLPSKLLKDSKNVSTAKESTENTEANVALETDKKTVEVKNSSSLFQEMRSRKMEDSASVSAAPPSPDSKVAPPAVGAAAPKLARRGGPPPPLKPKPDGRVPPTIPSKPVLPSKPKRASLLGSPAVDSPPKETSQASEFPTKKPLPPLSKPNPPPPSSSSSSSSADAPVSRRDLLRTTGSFRVDLSKSNSEIPPKKELKPTGSFRSTLGKTSDTPTSSSSSYLARLKSESENRKKSDAEKANGEESKEKSENLKSGNSGISGSSLSSIDASDKSSEREKNDAMKDVEQTTKLRRKSSVSHVESPLEKDRSSSISSRKSSISGSAYAPIGFRSPLSGSDNESKSRGSSVSSSDATPFGTSATRVELRSRDNSFNSFEGQRSRDNSVNSTAHIELAGSTVSSSTTDSSVKQSPLSVEKSPQLTVISKEEENKKEKADDTNKQLRSSSISNTPTTGPTSITPTKTKLTSSANGRSNQNEAADKKPMFGVQLRKVDKKTPQGNNSPSQPKEEDESPVKWRQQLSNKRRSFVPDKEPEKPKSDSTPEWARASIARRKRLMDAGVIKSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTM6</accession>
    <name>A0ABM0JTM6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101859417</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the stanniocalcin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101218.2">
        <property type="nucleotide sequence ID" value="XM_005101161.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859417"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004978">
        <property type="entry name" value="Stanniocalcin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245:SF6">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245">
        <property type="entry name" value="STANNIOCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03298">
        <property type="entry name" value="Stanniocalcin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047475193" evidence="5">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101218.2"/>
        </source>
    </evidence>
    <sequence length="207" mass="23234" checksum="DA5969A392977001" modified="2025-10-08" version="1">MGVYHVVLLALTVASCRAFWLSRGNPTALAEGRAVEESCLALADEGSCEFYTCFENRLPCGRDWYMLRHGQYYCNKMQRLSSTFTDAGQAFLSDAQRCLTQALKPLYQRDNVDCHSLEHQAVAAITPCFIDNAFCSVFRDNTDQFARIYDVGDLFTRGAGKVWREIAALALRCTHEYIRDFSSETHSNVVSSVNGMVDALRDAVEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVF2</accession>
    <name>A0ABM0JVF2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 2U1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101847887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102461.1">
        <property type="nucleotide sequence ID" value="XM_005102404.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847887"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005102461.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="58353" checksum="7DB21CF63527E0BE" modified="2025-10-08" version="1">MVSAYALVFVALMTILLFVLMRKKKTNIPGPPFFQALRELSRSVKSNCLHLVAAKWADKYGDVVFVNAIIRNVVFINSTSLTRKLFSDSSTRDISNDRPSSYLGRVFMKGFKDVGTASYGKEFVQRRRLFHKALNFYGEGVHSFEELMTNTSKHLSERLAKYRGNTPLTTEINGYIGWVVGLLLKGKDITQDDIDSVQTYIETGNKLFLLENEFFLETIPSIAQVPGLWLNKLVNKLKKADMEMDARFLTSVRETFKKGEKTGIITDLLEQQKQLEKNGNFTDMSDEIVQGLVKNILFGANLTTAGTLNSLFLQLMVNPKLQERIYAEICEVIGSDPPSFDHKRLMPYTEAVILEALRYSTVTPFLLPHCTNEDINLEGHFIPKGTSIFPNSWYFHHREDLWDKPWDFNPDRFLDANGQLLPSEHPTRQNYLPFGTGRRACPGERFSKLRVFFIFVTLVQQFRFLPPVGEELPSLNPETWEANSVIAPPDYSCRLERRSAAETGIELMAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWX3</accession>
    <name>A0ABM0JWX3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="4">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101864541</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005103483.2">
        <property type="nucleotide sequence ID" value="XM_005103426.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864541"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005103483.2"/>
        </source>
    </evidence>
    <sequence length="245" mass="27932" checksum="0BD8474BEE3E203D" modified="2025-10-08" version="1">MTHIHIVSIFFRENILINENVLSTSYKFNVKKVVSCMSTCNFPVKITYPFDETMLHNGPPHDSNFGFSYAKRMIDVLNTAYSSQFGCTYTSVISANVFGPHDNFNLEEGHVLPGLMRRIHSAKENNTPLVVWGTGSPRRQFIYSLDLGRLFLWVLREYDEVVPIILSVGEEDEVSIKEAADMVVEAMDFKGEVVYDTSKSDGLFKKTASNAKLRKYLPDFEFTPIKQAIKETCDWYVANVETARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXN0</accession>
    <name>A0ABM0JXN0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase DDB_G0268948</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103951.1">
        <property type="nucleotide sequence ID" value="XM_005103894.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858429"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="99"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005103951.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20458" checksum="E742DC709F9680E3" modified="2025-10-08" version="1">MQRSAHRLFLAVGKKMWKSSRNTIFHHPRHFAVACSNIHTTSTQSSEDAGSTSTKFSNPYDVKEIIDHYPKHRPTYADDTYVKIREFCEENNAQFDLALDMACGSGQATVPLAGIYKQVVGVDGSALHVEKAPRDLNNITYHVADCNLPLNFIQSGTVDLITVASAIQWLHTDKYLRHISAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYQ5</accession>
    <name>A0ABM0JYQ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable calcium-binding protein CML34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104678.1">
        <property type="nucleotide sequence ID" value="XM_005104621.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847205"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104678.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17447" checksum="6E8578C6259400A1" modified="2025-10-08" version="1">MAGRNRKVPDHIVKIFDKYTANNVRVLSKAHALEMLKAEFGLEGDEAEVMFNTFDKDKNGKLSVWEFQMFCTCMGEHAQEIITKFKELDKDGSGQLDGEEAREGLKELKTGTGRLLSEKEVDFFIQTAGDGGVIDLGHFTNLLYRLKLYNAPAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYQ9</accession>
    <name>A0ABM0JYQ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Testis-specific serine/threonine-protein kinase 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104683.1">
        <property type="nucleotide sequence ID" value="XM_005104626.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848374"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005104683.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38912" checksum="C270F0C33C27E82C" modified="2025-10-08" version="1">MSTMMNLHPEVYETYSVSATEALGLKEDKKVAKGGSCQVVVATDVNDPGKRKALKKLMFLDDECDYRKKRFYFCNEIRFLQNVQHPNIIQVDKALACPGEFVIAMEYHPIDLYGAMPCLTDAEITKYFTQVVDALLYLHDRHIVHGDVKLENVLIDMQGNAKLCDFGMAQLIPNKSSKLWGGTRAYNGPEYTRGQPVEDVFQLESFSLGVFLCALSLYIYPLKGLDYLELLRGAESVPDIHRVCAERLLCPSPAERASISEIHQLLNDHRQSESRPQLDVIDESPAPVVSVPKRRKRSHVKEEYRNLHSRGKALKLKTKSCVDSRTSLTPMFLTPNSCKHFVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYY7</accession>
    <name>A0ABM0JYY7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Pyridoxal phosphate phosphatase PHOSPHO2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101859658</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104823.1">
        <property type="nucleotide sequence ID" value="XM_005104766.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104824.1">
        <property type="nucleotide sequence ID" value="XM_005104767.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859658"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005104823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005104824.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30037" checksum="D47534D37685E376" modified="2025-10-08" version="1">MAEENERSVVAQKVLMVFDFDHTLVDENSDLYVRKLAPNGELPEEISSLYQDDGWTNYMGEIFKYLHRNGSTPENILNCMSEISLTEGIQELLHFTRKSTSFEHIIISDSNSVFIDHILKKNQLSSLFRTFTNPARFEDNGCLIIEQYHTQDWCPLSTVNLCKGHILNEFISERQQHGVTYHHVIYVGDGFNDLCPGLALRPQDFLMPRVGFKLHKVIEKMAEKNKPVPRSKLEASVVPWSSGLDILQHLRNLPFVKTGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K017</accession>
    <name>A0ABM0K017_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101849867 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005105560.1">
        <property type="nucleotide sequence ID" value="XM_005105503.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849867"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF14">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105560.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="43299" checksum="AA90CF7D3D4D71EC" modified="2025-10-08" version="1">MSPPAKKAKKTFPGSSDKAHPDVFNINAMPEQPKELKPGQFSEEKVRQYFEKGYLIVPEFFKKEELDACRKDIEKLVEDLAQWLYKAGKIKGLYEEHGFLQRLAYLEKDFPGSNILLFKTQGHMRKSFQALWSNERLLNVVEQLIGPEIMGHPVWNLRTKTPQNEATTVPWHQDSAYLDNESYSVLQPAAWIPLLDANENNGCMEVVSGGHLTGKIARHTCCWGNTWYVELSEKDIEDSLEVTVAKDKVLCEVPYGGMLLINNLIPHRSLNNLSNDIRWSLDLRWQRPDKPVGFYGLKQGIMMRSKKNPIKEIDWNSFNSVDRHTKADEELKGKEDEDEFDTTIVGPWMKKWEMTHTNRHTARLTDETLASWHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K033</accession>
    <name>A0ABM0K033_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polycystic kidney disease protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101856526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105591.2">
        <property type="nucleotide sequence ID" value="XM_005105534.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856526"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01752">
        <property type="entry name" value="PLAT_polycystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042060">
        <property type="entry name" value="PLAT_polycystin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="961"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1111"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1155"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1242"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1497"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1544"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1594"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1634"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1666"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1696"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="11">
        <location>
            <begin position="796"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1753"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1817"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1079"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1753"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1843"/>
            <end position="1857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005105591.2"/>
        </source>
    </evidence>
    <sequence length="1857" mass="210789" checksum="BE0436664DB50B1C" modified="2025-10-08" version="1">MTRCFPFFFTGYESKQISIEASLFETFNSQQMRAECVLTRAGEWGKVASDLMVNNPPAPGTCTVSPFNRTITSEEAWTISVDSWSDEDGIDEYQFFIHTDEDTVDKQITSVKTEQGTLSIQVSLSEGPHYLNYKQTIIVKVRDMLGSIQEYDCGQVVVLPMPVEDIRALTQDVISNQKHELARMFSEGDQKTCSEKSTNIVSLLNSDKYASQTVASNQANSMYGQGDLTRTNYQTPIISQDPEEEFKMESERNDRAEVRESLIESISKLPTQSVISIQQVISFYAEATVYGDEISQDSQETVMEALENMTLFMTDPESVDKVPSEDLEVAMENGIAAIGGIMDAAGNNGYRGTLKELEEAEEDEEWFVYDSSLNALGGEDDMSSAGTFDEAMKIHTARIHKIRQAKTAERVRQRVIRTLDAQAKVFSRYSVPGQTLLMRSVKMKVIMEKTDVQRLIGKTLNPPGSTGGVTLPDNAFIGGDPEETVVASVTQSTNHPLKYSDKAKGISPSSNFISINLYDDNNSKMTVSGLVEPVKIVVPLDANMPKPSYIEMDPIISKWTNLMLLVANINRSQSAIHLDFKDIEGRQFLLVVKKGKPAKIAVDRADDECDAVYLVPSSLSSTDPDRYRFYLSNNQLGNFVGQLSIGMRELNTTEYDMDISAGCASLPRYENGSDYFQGNFSLRQYVTQCLAISDSANDWSTDGCEVSKETNDSNNVCLCNHLTTFAGGWVVVPNTIDWSYVFANADFLSNPTIYITVMLTAVLYITAAIYARYKDKKMTEQLGIAPLADNDPKDKYFYEVLVCTGMRRNAGTNSQVCFILSGEDDETDVRAFSDSKRKIFRRGQVDGFLMAVPRPLGYLNFMRVWHDNSGKGKFGSWYLNYIVVRDIQTDLKQVFISNKWYAVEEDDGQVDRVIPVAGREQLSDFSYQFGERSKKNLADGHLWFSVVARPPQSRFTCLQRVSCCLCLLYVTMLANAMFYRAPDEAEDSGNSLSFGPFSVSPEQISIGIISNLIVFPVNFLLIFLFRKSRPHHKRPSRIDRAIKEVHQQNKMASVNDVKPEVGSIFSVTKSPSMLRDPNRPASSSSSRPCSAMSTGKEELVGKKKKKFELPWYFTIIAWVVLWVVTLGAAAMVTFYGISFKDDICKKWISSMLVSFFMSVFITQPIKVFLFAMILSIIIKNPAEDKEDEEEDEEMPHMDQDNELLHGDMAAFGATRPRKIGYKPPDPMELEKHRKRRMNEIKMWAIIREVIIYSFFLWILMVISYRQLGASNFLYKDTMHRVFIENNETDIHFSLIRNTDEFWIWAKSGLVNGLRAGSYYNDYPPLKLRAYINDKVSRIIGYATMRQLRIKPALCEIPDKMETLVGQCNIQYDILKQEERDFKVGWELFNSTDTANDTRPEYMYTTAGDLNGYPYWGTLGMYSGGGYVVNLEGSKADLINIMDKLEREKWIDRYTRAVFVEFTVYNAQVNLFAISTILAEFHPSGGLVQSFRFEPAMLLPYMTSAMLFQLVCEVVYILFTLFFIIRELRAFIKQRLSYFKSFWNLVELGIIAMSIAAIVIFFYRLFVTNDLTEAFKETNGNGYVKFQYVGYWNEMFSYMIGFLCFFATIKFLKLLRFNKKISMLSATLKHSAKGLMHFGVIFVIVFMAFAQLFYLTYMHIDVDYSTFISSVVASILMMMGKFNIYSMIMTEPVLTQIFVLLYVITVTFIIVNMFISILNETFTVVREDINKQGNDYEVVDFMLQRFKKWTGLGASSANENENPDGQNNPEGQFMPGGGPNSSDHIQDFPDRIERLLQSISSVYMDNDNLGQLYQKKRLDSQNINKSMLRSGRSPSPAPGQQFRGRKDSSDVVARVHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0Y6</accession>
    <name>A0ABM0K0Y6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neuronal PAS domain-containing protein 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101857051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005106185.2">
        <property type="nucleotide sequence ID" value="XM_005106128.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857051"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19697">
        <property type="entry name" value="bHLH-PAS_NPAS4_PASD10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056192">
        <property type="entry name" value="bHLH_NPAS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF39">
        <property type="entry name" value="DYSFUSION, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23183">
        <property type="entry name" value="bHLH_NPAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="866"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="790"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005106185.2"/>
        </source>
    </evidence>
    <sequence length="952" mass="103541" checksum="8F7D320681E7E93F" modified="2025-10-08" version="1">MAPVEEVALLDFDRSNKGASKQRRDQINAEIATMRDLLPLPESSRQRLSQLQIMSLTCVYIRKCNVLQKLFRSKSQDSPLPESLDFFQALTGFLLVTTREGKLLYISENVTDFLGHSMVDMKTQGDSLYDIVDKRDQDTVQAQLMAAGQPDPCDPDDVSFFCRMNMSRTLKRQSGFGDVKVMHVRGHFIRVSEPGSPVDGQCVFMATCSPLITPELKENLVQNNTMVFKTVHQLDMTVMEVTKTAEFHLGRSSEELTKQSWYAMLHPEDIHEAKEKHVQLIRSNHEMGSMMTVRMLRGDGTPFWVNIVMHVRQASLSQSDEPLIVCVNQVIDGQEAYQIKVQSHMFSMYPSRAHELWSSQLSSVTSSPDMAMGHWVQQNGSASVPVPGYQASMPGCMTPHGRPSIYHVQCPPGMTMSQGNKSVVGLPSPTFNAASAMVQSDRLKAMLKRKIQGPQSASCRPNKMAKTSWSMDDCSRGQGYSDVNSRNVPLMEHYGQVPMAMCLEGQGQSMQVLQPSNYRMGVLTARKSPEVLACQAMVAPSLSKVGGHMSASEQVVPDVNVPDSFLTPDPSPISSPQPSSNVSIKTEVMDPEEAAAQNKNSTSILQALEKLAALTQDAKKTEKVAAVPSPPRASLTQSARPDTTSVSQRRKELPIFDAFEIETFFDTLDIPELKPKASAKMEIKTEIKQEFPTEKMCPGNIPNILALKEEQCTVPVYKASSSPQHGSPAAAAAATTGTGSESRFQSPFPFQSPCEMIVPGEMTGGHSSQAAVRSPVISSSPSPGSPSSDLHGSQGSMAGSPQSSVASPEGSFQDLLSCFSDDGLDLSPLQMDPRSNILDSSVSEDLLDDPAETSFLSAFYTNTSPDFDKSSNRGGQKLGSPGLPEELSPHSTSSLLAGEEEEAMGEGSDFTLAMALESLGSDDEACATSLKARDVLGMSDELKQLDLLLGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1D4</accession>
    <name>A0ABM0K1D4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Aspartate beta-hydroxylase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101859810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106461.1">
        <property type="nucleotide sequence ID" value="XM_005106404.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005106462.1">
        <property type="nucleotide sequence ID" value="XM_005106405.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859810"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051821">
        <property type="entry name" value="Asp/Asn_beta-hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332:SF5">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="5">
        <location>
            <begin position="203"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005106461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005106462.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42903" checksum="DE61A7B53BCFFA5F" modified="2025-10-08" version="1">MDTSILFMFTMAAVLMLCVVVLEMWLKGRRQSGILTYWYAGFGNLWRYFTWCKDSKEEENTFESHSFRVKDNRQDSTSLCTSPNCIRCSRNLEILSTALTRLSYYITKSPNTEVQGDQSAQNEYHSLVADIKKSLDYAKNREGKESVKSLIPDSVSEASDSSSVLKSMPVESSLRPLVLQLSGLREQEFWPHTEFSALIALRQAWKHIMLEFVHLYKSPFPETQRLWKTNATVDGTWEIAQLVDQGRTTKAAEFCPLTMDLLKQIPDFLSDCYFGDASFSIVHPGTSIATHCGSTNCRIRCHLGLQVPQDLCTLTVGDRNRCWEEGEIICFDDAYPHSVRHHGGVESGFRAVFMIDLWHPDVSPAQREMIRYAFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K279</accession>
    <name>A0ABM0K279_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium/calmodulin-dependent protein kinase type IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101845267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107008.1">
        <property type="nucleotide sequence ID" value="XM_005106951.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845267"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005107008.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21191" checksum="FD49F68C22D14755" modified="2025-10-08" version="1">MPVLKKQDFWIKQSTKEESFDSQYELGKELGRGATSSVYKCERKGLGQAWAVKVLSKNIEKKVLTADVGILLKLEHKNLIRLKEIFESKSRIFLVQELVTGGELFDRIVNVGTYSEAEASKAVQDIISGLMYLHSWGIVHRDLKPENLLYENLAEDSKLKISDFGLSSILSPEVDMTSVCGSPGYTGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2G2</accession>
    <name>A0ABM0K2G2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101863293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 4">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005107165.2">
        <property type="nucleotide sequence ID" value="XM_005107108.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827983.1">
        <property type="nucleotide sequence ID" value="XM_035972090.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863293"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021123" description="Beta-galactosidase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="7">
        <location>
            <begin position="41"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="8">
        <location>
            <begin position="406"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="9">
        <location>
            <begin position="547"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005107165.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035827983.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="74395" checksum="66E1B693E65BAB89" modified="2025-10-08" version="1">MAVSTFASIMNSSLFIIVCVFLLGAKVSCERTFEVGYQNDTFLKDGKPFRYVAGSFHYSRVHPYYWEDRFVKMRAAGLNAAQVYVPWNVHEKTPGVFTWDGASDLGRFLSLAQKNDLVVLLRLGPYICGEWEFGGLPAWLLNENPDMFFRTSDNSYMRFVSRWYEQLLEKIKPSLYINGGPVVMVQIENEYGSYFACDRAYTASLRDKVREILGNDVVIYTTDGAGDGYLKCGAVPGVYATVDFGTTLDPAASFKAQRDYEPHGPLVNSEFYTGWLDHWGYPHSTTDRTRVAKSLDLLLAYQANINMYMYIGGTNFGFYNGANSPPYQPVPTSYDYDAPITEAGDITEKFYAVRDIVSKYLPLPHIPIPANTTKTAYGVVPMSFVSTVQDALSVLCPEGPVRTAYPIPMERIKFYFGFILYRFILTKDYSSPTILYTRGIRDRAVVMVNAVPFGILKREFQMSVNITGSKGQAVDILVENQGRIGFSTNMNFNIKGIVENVTLGGELVSDWWMYPLHLENINGTTNIPRKLTHSVAPHSSDGTMTTPSIYVGEIDMPGSTEPQDSYLDPRPWGKGQAIINNFNLGRYWPKRGPQVTLYVPKPVFVNPPAVNRLYLFEVDSAPCFDSTGDDGCNVTFTDTAYIDGPNTPDTVSSKFESYKLTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4T4</accession>
    <name>A0ABM0K4T4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ homolog subfamily C member 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101856053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108749.1">
        <property type="nucleotide sequence ID" value="XM_005108692.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856053"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005108749.1"/>
        </source>
    </evidence>
    <sequence length="640" mass="74013" checksum="E522249E1C6042B8" modified="2025-10-08" version="1">MATKIRCHYEVLGVERDASADDLKKSYRKLALKFHPDKNPANVEEATAQFRTVQQAYEVLTDPQERAWYDKHREAILRGGLGGGDKYDDDSVDLFQYFNSTCYSGFGDDDEGFYAVYRQVFETLAEEDYVFMPDRKKDEEFPKFGDSSSDYDEVVGPFYAFWTSFCSNKSYVWVEKYDTREAPDRRCRRAMEGENKKLRDAAKKERNEEIRNLAAYVKKRDKRVQAYKKFIEERNAEIERKTKAKREEQLRDRQKRMENYQEASWSAMSELEKDLEQLEAHLDRHFGDGEEDVPGAPEDAELETEDVEEELYLDELYCVACNKAFKSDKAFSNHEKSKKHKEMVAILAEEVRMEEEAENGASDEEVEEEERKEEDVEELEEDQQGEQKSDSAETEKKGNGRSTEESNVGSLDPVLSDEEEEDDQRQRFSQKQKKKRRQKKLLEAEEDILTEKIAEVRLSEEELPSKKNKSKKARRRANKGTAKEEMGNQAREEDGPDSRCTKPALEQDRVLETAEGDGDEANVTEEKEECSAPKEDVKKEECAGEELTEAKDGEKEEELTEAKDGEKEEEQVSKENGEVNRRKNRKDTVKCNVCQKGFPSRNKLFEHIKQTGHAVRLEAPAAAPAVEEEKGKKGRKKNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4V6</accession>
    <name>A0ABM0K4V6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101849564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108804.1">
        <property type="nucleotide sequence ID" value="XM_005108747.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849564"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005108804.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="37508" checksum="809613F7B136B97A" modified="2025-10-08" version="1">MAGPRQTPLTCSGHTRPVVDLSFSDITPFGYFLISACKDGKPMLRQGDTGDWIGTFEGHKGAVWGATLNSDATRAATGAADFTAKVWDAEKGEELHSFSHKHIVKSVDFSSDSKYLLTGSNEKLLRIFDLEKPDAEPKQFAGHTSNIRAVHFNKECTRVLSASDDKTLRVWDVNNCQEIHCIEVPSSPGSLELTSDGTIFTITYGNFTAFYNAETFEKIKEIKAPAPVNTASLHPSKNFFVCGGEDFKMYKFDYFTGAEIESFKGHFGPVHCVRFSPDGELYASGSEDGTLRLWQTTVGTTYGLWKCVAPDIEAGDTSTSSSSSSVTTTTSTTTSSSATAVKVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K550</accession>
    <name>A0ABM0K550_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 1 regulatory subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21 22" type="primary">LOC101852209</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21 22" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Component of the PNUTS-PP1 complex (also named PTW/PP1 complex), composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA (or PPP1CB or PPP1CC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108983.1">
        <property type="nucleotide sequence ID" value="XM_005108926.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828434.1">
        <property type="nucleotide sequence ID" value="XM_035972541.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828435.1">
        <property type="nucleotide sequence ID" value="XM_035972542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852209"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="18">
        <location>
            <begin position="71"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="15">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="144"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="850"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005108983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035828434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035828435.1"/>
        </source>
    </evidence>
    <sequence length="994" mass="109570" checksum="32B499B0463371D6" modified="2025-10-08" version="1">MPPIDPQQLLKALGPLLTNSGGIKGAQEASRIASLMKDATKLVSRCIYLNILRVTDSPSALEKFIEVGGWDTMNTWLDFSRNDSNDALLGEILQAYLNLPVSVTLLKKNSAAKTIKQLSKAENEKIKTLSSQLVDAWTKTIRGQNNKEESDDKKKKKKHKEKEREKSDKDKENDKKEREEKDSEKHKRSDKESKEHHHRDKDRKDRDRHKDKDRDKERSRDKSKSSNENNKDSTKSSSSSSSDHPSSKSKDPSSSSKKISLPEEAKASSSTPSVSTPAGTVPSSKTDTGANKEEESRRRPKTVKQLNTRFRSTGLFDEDDEDEVEPVKKKLDKPPIKRAGLEMRGEDLIEKKPRLQLTMPTLTPASVDLGNMTPPEVQHGRIKIIPPPKRAPAHEIQESNVFMDALQQSSYTHGPLKKKKKLTSPSATTAPSSLLRGSHSLSPPSATSPPQATSPPEEETGPTSPPLLSPTAAMAQKLPSVPSFYRDTLEDMPEPTEEKEDNVEEEDDGPPVVEGMDTSEASPPQLDQSDADISMEQSEGLSNESKESSENSSDKAPVSEGEQRVKSTKPKKSVSWARESQLEEYFYFELDETERENVNRPKSFMEMKKEEMVLDKRAMESAKRLNNDFMVEVLPWKRPKLIDDVIEVVEPGCNSQEKVVQTERERAVLCALFFNKVPDTPNEPDPDMAGEENDMKVIPLEDENGSCTEYEHTYNFDDPSSLPYDPEFGGLPLQNQGPAMNQGHMGMNNNMGNNMNANMGGGGGGANMGYKMPPALSHLLNTLRQQAQETQDPLMQNLQGRLTHVLQSTNPQDSGMLMDRILNALEPFKNQIPGLSGLISSVTNNGMDPNMGGGSGQGPRGMMGPNQMGNPRPHGGLLGSHPPGFNMMGPGNMRPNMQGGPNMPGPNMQGGPSMPGGPMMGNGGGNMNPNFYNRGPRPNMGEMRMGGPPQWRGGGRGRPFGKRGHKNSVCQHFVKKGNCRYGDGCQFIHPGPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5S4</accession>
    <name>A0ABM0K5S4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 22 member 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005109387.1">
        <property type="nucleotide sequence ID" value="XM_005109330.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846772"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17331">
        <property type="entry name" value="MFS_SLC22A18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="73"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005109387.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="48744" checksum="1581B4467446B65A" modified="2025-10-08" version="1">MDDSTRLRSTAKEGSSQENDPTSQMSSESLPTQSDTKTYNDMSFSNNEDSKKESAEVSQAATVRIAGYSFNKIVLVAHVNIFLYSTCFWIQNAVFPYLSKRLGADPVIFGYLQTTFAVVQLAGSPLFGRFGDLFGSRVAMILAYLSAASSYFLLYLSSNMTLLFISRLPSVFMHAMQGGQMIVTDVCNPKERAAALGKLGLSYGIGMVVGPIAGGLVSKFFSLETGALLACFGSLLSVLLIVTFVPAQVKKVQKPGAGETVFSLNKIGQLLAAPGALFLMVIKLGTGIPIGIFQSMFTIITLEIFKLPPEQNSALMSYVGVMGMIVQGVGVSYAAKAFSEHTLLMGSAGILAISYLLLAYASSIFQMCIIFVPLITGLTFQNIVTTSALTHTVPDSDTGAMLGLSMAVNSLIRSISPTAGGYMLENLGFESFGWLGFFLSAAVTVVLFLRQQRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7S2</accession>
    <name>A0ABM0K7S2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862077</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110789.1">
        <property type="nucleotide sequence ID" value="XM_005110732.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862077"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110789.1"/>
        </source>
    </evidence>
    <sequence length="942" mass="103434" checksum="591D2FAA59329A52" modified="2025-10-08" version="1">MAMADNILGNSRNKRCLSQTFSSLKNGDFKYKSSPWEGLCYYCMDCLSREMPCGHFFCSKERLFRESPFIDLVYEESSRTECSSRDLLNGECLHDARRSGERICVECQNESVRVLVEWHSGERICRECKAETVRIQDENNSSSPADNLRSEVEDSNPRGVEQISPREGPSCSVGEDGRRATTKPSSRRAFQPWRHLPAGRGRGRGEEKQARGQCGESGHSSLCHYVDDGEGKLVRDFRTQVTATDIKPSREAQTGSSLRLEKRGESEVLPGVLNDPSTDCLLLTSSDLLKNMDAENAHLTSHDILKNMSTKCVPRLCPRMWKEKEERAESHRHGSKNMPKIEKVKARHTKTVADFPPRVVAPDICVRASAQTEASPRAEGSAALSGPASAGGVHGSESSQPDARVPCQTPSCVARGSAGEGNHCLHSPVRATDIQDSGRAQTCPSLVSTVDPFVPGERARRKMDVHRGSRSETWEDLEFRSDDEQRAKRSSPDKQKIQNPSPDKLKAESPLSDNRKVGCLPPPSPSKQTPDKESSPVLCRVDNCPASVIQTELSVAEELLSIGGPGVVDRAAEDGLGRGALFLAQTGARYNSSHAGTQVVVLDLGTCAHTQTEECSYLTLSPDTIKPKLLESVGHVSTQVLALNLGTCTHTQTAESAQGSHTKLNLDANEQKLYERVFPHTEVTSVTLNKRSDPQALAASPRKVNHSYVTQMGWPGVAILDNFSRSRLHFVNPESQQSARAAGVVDIFPKKQQQRLDDLTAPLADLNNYRQSQSRVEFLPAAKVSVNRVCQREKVADNSDGAGGRMKIMICAQKEIACDEEDNSNKGDEKEEEEEEKEGQAHGRERWDEKEEHSEVQPEELTLLLRDRFSDSLQDVGTAGVTQMSKGTERGGTGGGNPGNLGRRQHVPYRRKRIRNCGPSVSTQTQGTAGSASSREDTPPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA18</accession>
    <name>A0ABM0KA18_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101862850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_005112524.2">
        <property type="nucleotide sequence ID" value="XM_005112467.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862850"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005112524.2"/>
        </source>
    </evidence>
    <sequence length="132" mass="15244" checksum="61B1653294CEC8B2" modified="2025-10-08" version="1">MLKTYRFYLSLENSFCQDYVSEKLLLLYKQRNHTIPVVRGGFDYDRNLPPDTVINAAHFRSARELGVYLKELGSNPDRYAKVLKEVDKLTGLGHFIDWCDICEKINTVTASKKIPDIKAWSHEGKCHPPKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA71</accession>
    <name>A0ABM0KA71_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101853280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112645.1">
        <property type="nucleotide sequence ID" value="XM_005112588.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853280"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005112645.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="53736" checksum="07D61B710EC22D07" modified="2025-10-08" version="1">MGNTTTSPSTRTVGDSSDSDTNTTANINCATDAVKSDEPREDWSVLKADIARLNQGDREMEICFGDSPELDLGRHFKRCRKNPGHKDFISVKDVSLQHIPEPWRHPNVLRAVQLLSAFTVRLVVRYTSMKRPNEFGSPNLKGTKVMRLGSGFFDIGALERDRQNQPCPLKNCPLSSDPDHEVSPFFYIQTAAHVVFDDQEARHTTVEFFYDSEDDKQTSVVRCQGVTVAGGTLSDDHSQLKCFTHDLTLLTRLESLLDLAQPEPNILPKKSSLCLVISHPHGCSKHISFGVLLDLRELNQLTDNLILEGCQKIYEDRDYLKTIGLTDADIDRIRLLMDMNGGTTTFQAMKANGVEQTLNQFPNASELKECIDLLRASPANPGSGIAQFTESIMDYFKAHQDERAAAGFQELMNITKSVWGKNRGQMMWTIKYSAATCPGSSGAPVFVLDTRSATCRILGGPHSRCGRDGRNQSGLSTSMPFQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUR2</accession>
    <name>A0ABM0ZUR2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Melanoma-associated antigen D1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934861.1">
        <property type="nucleotide sequence ID" value="XM_013079407.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011072"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012934861.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15727" checksum="5024D7576DDDF5B2" modified="2025-10-08" version="1">MAWCRGLAWCRGLAWCHGLVSWPGVAAWCRGLVSWPGVVAWCRGLVSWPGVVAWCRGLAWCHGLVSWPGVVAWPGVMAWCRGLVSWPGVMAWCRGQVSWPGVVAWCRGLVSWPGVVARCRGLVSWPSGIMAWCRGQVSWPGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVK7</accession>
    <name>A0ABM0ZVK7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC101848808</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093891.1">
        <property type="nucleotide sequence ID" value="XM_005093834.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012935445.1">
        <property type="nucleotide sequence ID" value="XM_013079991.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848808"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19343">
        <property type="entry name" value="Wnt_Wnt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF102">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021883" description="Protein Wnt" evidence="10">
        <location>
            <begin position="26"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012935445.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39937" checksum="35489320538A09B9" modified="2025-10-08" version="1">MRPPNLCTVLRVLLVLLLCAERCVAVKWLALYRIKQRPWETTRNCTRSSGLAARQMKLCRDNLDLMSTVVHSAMVSMETCQQQFADRRWNCSSILRVPSLPMDLVRGTREQAYVYGISSSALVHSISRACSIGVTTKCSCGVLPNTTPTGNFKWGGCGDDLHFGLLFGEAFTDATLRNKKGKVKTSKKAMMNRHNFRVGRKVVADSLTQACKCHGVSGSCSIKTCWRALPSFDSIGALLKDRYALAVEVRRKRRKKMKVLIPIHKGRASFRDDELVYYEKSPDYCSPDSKTGSVGTRGRLCESSGWGPGNCDSMCCGRGYNNFTMEVTERCECKYIWCCYVKCKVCTKLLKLSQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWE1</accession>
    <name>A0ABM0ZWE1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-coumarate--CoA ligase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106011302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935910.1">
        <property type="nucleotide sequence ID" value="XM_013080456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011302"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012935910.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24577" checksum="BB99A7997CBB68F2" modified="2025-10-08" version="1">MVCGQPLRKKCFQEAFTISEKLLVAYGSTEVGGASGGILSEEQLDEVQDFFCGPVADYLSLQVVDKDEKECAVGKVGTVMVKGKTLFSGYFNQLEEKDPATTGQFSEDGWFDTNDNGYFDHKGSLYVIDRNNDVISYGACLVYPGWLEQKILAHPKVRDVCLVPKTVVKGKLCLRLIIKKLLQFMFVDSRMGSTFERISLAAVGVSLMPPSMKERALFWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWP1</accession>
    <name>A0ABM0ZWP1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Follistatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101845455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936059.1">
        <property type="nucleotide sequence ID" value="XM_013080605.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845455"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012936059.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31982" checksum="BDF390718C292325" modified="2025-10-08" version="1">MRDLYLSEQASVGYPAKRPLQKTQMSSKSVSTNMHRRSLRGVCTMHLLLLVFFASLCSSTVASKYNNFNQCATCDESRCPELHYCEGQPIKDHCGCCTICSSSRFQPHVVVVKPAGGNACEQVDCPKFKVCVENMQGVPLCTCPSEFVCRRNKKREVCGTDGKTYPSRCHMRIASCNQGVAVRKMYRGPCSPEDEEKEAAKYNRRLKKMKRRRRQRKRKANESAGEKGKKRRKHRRRRRRKSGSRNGKGKSRRRRHRGSHSNAASRTFEEAFAQYTWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX09</accession>
    <name>A0ABM0ZX09_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein Fe65 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936253.1">
        <property type="nucleotide sequence ID" value="XM_013080799.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847028"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01272">
        <property type="entry name" value="PTB1_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01271">
        <property type="entry name" value="PTB2_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="64"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="255"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012936253.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46328" checksum="E3C853BE28EF8B9D" modified="2025-10-08" version="1">MASDSGSSSSASIPSTPGSVGSSTERHLAEFEGHALQYAAKSLQSLSSRQASQKEGSSERCARFSVRSLGWVRIAEEDLTPERSSKAVNKCIVDLSLGRNDINDAVGRWGDGKDLMMELDHVSLRLVDPVDGVTLNSQPIHSIRVWGVGRDNGRERDFAYVARDRVTKLHMCHVFHCDTLARHIANTLRDICKKIMLERSLHQSAVARLSRPTDLPNLDKVNHPNGEKLSFQNLYNNARFPTPMEEPRKVMRCHYLGVQEVMRPTGRDILNEAIQYLYYRIPPEKWKFVNVAIAPSTITITEHGNPDGIIEECRVRFLSFMGIAVDNVKLCAFIMHTSQNKFLCHVFHSEPSAGPMCKTIEAACKLRYQKCLDAHPQTPKGGLQGKFSLKRSLSSSIKQSIQCVWGSVTQLASPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY51</accession>
    <name>A0ABM0ZY51_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytohesin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936913.1">
        <property type="nucleotide sequence ID" value="XM_013081459.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858484"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01252">
        <property type="entry name" value="PH_GRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF402">
        <property type="entry name" value="MIP16918P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="61"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="266"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012936913.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46362" checksum="D359E7927633412A" modified="2025-10-08" version="1">MEPTSVTSSGNNFNISDLTDDEQKLLKSIQEKKHLLLLEIQELKREIEEVTNELEGIDIGDENKPDPKAKQISIGRKKFNMDPKKGIEYLIEHGLLQNTAEDVARFLFQGEGLNKTAIGDYLGERNDFNVAVLKAFVNLHEFTDMILVQALRQFLWSFRLPGEAQKIDRMMECFAERYCSLNSGVFVNTDTCYVLSFAIIMLNTSLHNPSVKDKPTTERFIQMNRGINDGGNLPEELLTNLYDNIKKEPFKIPEDDGNDLMHTFFNPVKEGWLMKQGGRVKSWKRRWFILNDNCLYYFQYTTDKEPKGIIPLENIQVREVSNEKTKPNCFELFSAGSSEIIKACKVDSDGKVVEGRHNVYRMAAASVEEKDEWINSVRASINDNPFYDMLAARRKNATGSSGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY75</accession>
    <name>A0ABM0ZY75_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Short transient receptor potential channel 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101855636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012936952.2">
        <property type="nucleotide sequence ID" value="XM_013081498.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855636"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF79">
        <property type="entry name" value="SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="62"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012936952.2"/>
        </source>
    </evidence>
    <sequence length="539" mass="60625" checksum="E0DE0D0713BCDD5A" modified="2025-10-08" version="1">MNSFTHKLLLQCLPSFSGLDPVFTPLQCSRFTHIYVYICIPMMYYIQNLPSTSTQRSKCFHILLTSLLDRMFWSATDPINLLEGQFAMANILSFSRISYLLPANEILGPLQISLGRMLKDIAKFLALFTLVILAFMVGLHNLFWYYSERKGIELDLPGRPPSENVRAEESFGEVLATFRTVFWSLFGRGEPDAVELGTYNNKFTEDIGYIIYGGYNIVMVTVLLNMLIAMMTRSFTLIAEDSDREWKFARSLLYMDYIGNGGTLPAPLNIIGAPKALLRLIFCRCCCCGEEEEAEEPEEDEMQPGSRGTRRNLPLANGHDSPRSPLAKQPSLDGPSGSAHPNDDISPAEFHEANGRVNQSFEGTPTKSTPRRNPSTMVPMEAEEEKLTYQQTMQRIVQRYIFDIQREAEVTEDDFEEIKQDISSFRYDLINQLTTKAAVEDELKLSMGAIMQQLQTLREDVNPKAAAENQEKRQGKIFEKKSESQSKFKADLPGSSVIKEEPCAESSPAEDQGNPEDNEAPETPEEAEASETPTAPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYD4</accession>
    <name>A0ABM0ZYD4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011545</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937066.1">
        <property type="nucleotide sequence ID" value="XM_013081612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011545"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF1">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012937066.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16292" checksum="5FAB55CFA309A940" modified="2025-10-08" version="1">MKTMSWPFNAYMSVLSALYVGGFERVYVHGNIHPSGEWWDRLKDENVTFVEMDAVETVFQQGVASPAHNSDIIRTLVLLKHGGVYQDWDVIWTNPVPRALRRYPAVLSTDWPRYGDFPGAFNLGVLMAKPKAQFLRHFVDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYM9</accession>
    <name>A0ABM0ZYM9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Brefeldin A-inhibited guanine nucleotide-exchange protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937243.1">
        <property type="nucleotide sequence ID" value="XM_013081789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011600"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012937243.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="33273" checksum="3BF7880AD74D64A0" modified="2025-10-08" version="1">MGSYHSCVMVQGALQAAMVTMINKFVGGLIEKEDGLVEDGDDILADFKANSKSGSTENLIREVVQILTFLTDRLETVASSGHGKQALPVLLESVNTILEKVPVAIKHNPGFQELLWKRLCPCLIVLLGEPKAEKIANQKTGRPEVAKTGGSSTSSPHITHAAAKVIYNIAGELASLVGEIPALRPVLESLFHKMLMFPLPQNRHDALRVVKELMSEPQKVISLIGSSGAAGEKARGQTNLALIKLLVDSVQQCSHCADPGILYSSVCCVDSLLASLDRIRQGEAIPDSWLKQDKSSKSQGSLRRSMTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYV6</accession>
    <name>A0ABM0ZYV6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oral-facial-digital syndrome 1 protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937373.1">
        <property type="nucleotide sequence ID" value="XM_013081919.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850884"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055289">
        <property type="entry name" value="OFD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39063:SF1">
        <property type="entry name" value="OFD1 CENTRIOLE AND CENTRIOLAR SATELLITE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39063">
        <property type="entry name" value="ORAL-FACIAL-DIGITAL SYNDROME 1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16045">
        <property type="entry name" value="LisH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="851"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="888"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937373.1"/>
        </source>
    </evidence>
    <sequence length="1009" mass="116358" checksum="CCFD6ED58C5C386B" modified="2025-10-08" version="1">MANQNPEYLTAEELRNRLYHSLRNRGLVDSIKSQLRNSLVTELQQSVRGPLTLKDLKVPDGGTLLHRASNSLVANHLRACQYEYSLSVFLPECGLNQDKKFETQDLVKLLNISPHSRLYQRLSAQSQQDSKKGFLWQLLTEVSALHANSSSNVGCQTDLIKVGPITSLDEKLTDVDELFSSRREDFMRTGRAGAEERLLSFQRQLEDRYNTQLKLELARMRDAEIASIKTEEKENGRKALEQARRELERVYKDKHDVLVQRERNAMERLQQQTDLQDRETYAQRQSILEEIEAVRQREAEVKREAEVNKREKKVSEDRVKDKEGDLRRRELEINQKETAFEQRLQNEMAQFKLDQQARYIERIQNVEVREAKVKEEERIVSEDKSRLQLVKDELRDKTHRVNELETLLSESKYSEVNANKNNEYLNAKLRDMSDYKTLKEQVVMYKNELETLRTRLAEVLSMNERERGRQEELLRELRRPSPEALMLHRDLEKTKENLRQEQVVFEQQKQLLEARLKEELDRNKDLLQRFEEQTLQMREMNREIVDLRQNLHMTTRALNTEVYRKPADETDGAVLNESRSSGRNLAGSRHLVDFGDGDSNPKKSLRFEPDQKDVYHDVDFDLPSVSHSRAGGYLDDDVSSTDSADIIAQAKYRLKNLDREAHTLEKAYHDFHCRMTNINALPADPPPPRSTHATPQAGSQQERNMGSPRQSPIPFENPMSSTPYKRTRMAQDLNDSFAELGTQSHQQKKTSVPTQLDLSAVGDDPVIVESGDAERRVKMRSITVDDLDQRPGSPGIMVVAESVSSTDDTVKKVSERTHSQSGPPPGPVQRHVLLEPLVTVSSVPPPPVPEPAVASFVPTTTTPTVSSQPFSLDSAWKSQTEEEEKGDEEARRRQKEMEAELERQEERRREEEREEQRLNAEREKAEQEAQAAAAKEQEEEEKIDPVMKQYMAMVQQQKEKEKEVTKKAVHTWSRGHSEEKTPPQSDTEGLSAAAPDESEKDDDDDGFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZK2</accession>
    <name>A0ABM0ZZK2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/arginine-rich splicing factor RS2Z33-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106011726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937772.1">
        <property type="nucleotide sequence ID" value="XM_013082318.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011726"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012937772.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15860" checksum="94417C3B1D099405" modified="2025-10-08" version="1">MSNPLRCFKCQNFGHSQSRCRHAVVCRRCGKTGHPEKECKASPCSPILPRASTQPSVRSASSKSRKRKMVASFRRRERLSARQLRLRPQAGLFRRLSGWVTLSTSTSSADLAEPMVNRQRASPKSEKPPPRPGATLKTASWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0I7</accession>
    <name>A0ABM1A0I7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Delta-like protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938351.1">
        <property type="nucleotide sequence ID" value="XM_013082897.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853319"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="2"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938351.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14546" checksum="A54B73787D64BFAD" modified="2025-10-08" version="1">MCENNGSCVSSELMSGVVCECVPGFSGSHCELEDPATSTSVPRQGSVPRWFISDLDPTTLIILLAVLLGLGLFLLVAVSIARRYRRRKPSDFCFSLPRDLRGDMSRRDSETSSGHFYHGSTLGSDSYFHVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0M8</accession>
    <name>A0ABM1A0M8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101857720</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938422.1">
        <property type="nucleotide sequence ID" value="XM_013082968.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857720"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938422.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="85810" checksum="FB6D00DBCE6DBE44" modified="2025-10-08" version="1">MAETKLLPLELRQLVCCRLLSHNREVITLDDLEPTGRVVPLELGKLRRTTRRVAALLRQPEAGDFLTPKPKARFPANICYVCRALNPFTRTLRGVCHHLPPAPHPSFISEKDVRRDFHAKIASNIRHNSRADLESQGESRSRDEEDEGVASGDEVFDTSVLHAADADSPAHFSLPPVFSKAGPTRATPRTKRVVPMVSENTFVTSNCKPSFDDEDDGSDNDATNRTGSGDVNSRDARGTPEPSSRKFLTSRSRSSGEKVTRLPEVRRGCSLVGQVLEEDDVDEDDDGLEDEKEENFDDGDDGDDNEGKADVSHRHQVRRETLKTRRRPGQSSTSRGADERAMRDQPHDLEMTSRSDPGTNHHVTLESELTGASLHIDEDYVPMSVTIKKLTEADLHDRGFSRYQDYSDVLSDSLSGSLGVSRDTSLADSEEGGDSPSSFMARLREASWCECPQSDSDSGQCRECRGSGGHENWCVSAGSVCHGCRKPIKKVKGHAHMRRRRSTKSLEDPASRRSPDTMIATLKGNKSLHDQRGCSAKQKERKRKNKGRGGKKSREADDDDEMEQRVRFNDTVQQVSPDNRKRLPKTALDYENLRNYDHVRSPETSYYNKQSRGKKGEGDGWATMVERDLDEEEANRSKKVRERPKSLDDYRIPGVGVNVHRAAYILALQDARIRNSSKKNNNSKKKKRGGKKGGEATTDYPGTVFSYFPLLRKPVSESESTAQSSSSSTLGLRQAEGSKVKLKNAMKHIFGSVKMADYYPGGSRWRKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0Q5</accession>
    <name>A0ABM1A0Q5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011878</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938461.2">
        <property type="nucleotide sequence ID" value="XM_013083007.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011878"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012938461.2"/>
        </source>
    </evidence>
    <sequence length="133" mass="14850" checksum="075EA1B64250A9B9" modified="2025-10-08" version="1">MKVITPSHVHNLDLTRASRVLHESVRVISVEPGDEEEEEFRISEIDPDLHLLDGNFFENHSTGTILSIHKRPDGKYHVEGHLSHSIVIAPPGSGTRHKRSTGDHKGHFVYTTGAEDYDRDLSGGEAIINVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1T1</accession>
    <name>A0ABM1A1T1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA-specific adenosine deaminase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939084.1">
        <property type="nucleotide sequence ID" value="XM_013083630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858634"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012939084.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="20995" checksum="4DB94373CBD02919" modified="2025-10-08" version="1">MNAKEWMRKEDMTTALDCHLGWMRKALGFAQRALEAQEVPVGCIIIYDDKIIANGGNEVNKTKNATRHAEIIAIEEVRTYCAEKKLSSKDVFKSSILYVTVEPCIMCAGALRQIEIPLVVYGCRNERFGGCGSIIDVSCDKAITSNIGPTFDAISGVLADDAVSLLKNFYKGENVNAPDSKRKVKKEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1Z8</accession>
    <name>A0ABM1A1Z8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939201.2">
        <property type="nucleotide sequence ID" value="XM_013083747.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864628"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="213"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939201.2"/>
        </source>
    </evidence>
    <sequence length="358" mass="40569" checksum="6DFE6CAF54C850D5" modified="2025-10-08" version="1">MFRTSMAYREKMKVDTLLSDYEPPEVLKKYLTGGTCGYDKDGSPVRVELYGHLDMKGLMYSARKADMERVKLKQCEAHVRDWAVMSKKLNKRVDGLTVIFDMDGVSSKMLWRPGLQMYLHLVRVLEDNYPEMLKRMFVINAPRIFPILYKICRPLVSDDTKNKIHVLGSDYSSTLLKYIDAEELPAFLGGKKTDPDGNPRCSTLICQGGNVPEEYYLNEAESSEHMESTTVPRGDKFSVDVEVTKPGSVLRWEFKTDGYDIGFGVFRVEGKESVAVVPVERVNSHMVPEDGSYTCDVAATYSAVFDNSFSWARGKTIHYTLELVQPLDEGTASEIRRMLEEGVTLDTLHSDTILTTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2A7</accession>
    <name>A0ABM1A2A7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Glycoprotein hormone beta subunit isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11 12" type="primary">GPB5</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycoprotein hormones subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939383.1">
        <property type="nucleotide sequence ID" value="XM_013083929.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939384.1">
        <property type="nucleotide sequence ID" value="XM_013083930.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939385.1">
        <property type="nucleotide sequence ID" value="XM_013083931.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939386.1">
        <property type="nucleotide sequence ID" value="XM_013083932.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939387.1">
        <property type="nucleotide sequence ID" value="XM_013083933.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100533380"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00069">
        <property type="entry name" value="GHB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001545">
        <property type="entry name" value="Gonadotropin_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515:SF13">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glycoprotein hormone subunit beta" evidence="6">
        <location>
            <begin position="110"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012939384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012939385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012939386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012939387.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="20441" checksum="CB183652198BC2B1" modified="2025-10-08" version="1">MSLASWLADRRRLASSSSSSSSLSSSSSSSSSTSSSSSSSPTSPALSSSSSSLLPLQLPLLVVAMSCLLARPSSCHLVDPRTTLSCHVRSYQFRVTKPPVISEDGQILRCSGIVTVNSCWGRCDSSEIGDYLMPYRISHHPVCTYTGRVPRQVTLSGCEDYPDPTFEVFDAAGCECRLCDSDYTSCENLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2H4</accession>
    <name>A0ABM1A2H4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012130</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939511.1">
        <property type="nucleotide sequence ID" value="XM_013084057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012130"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012939511.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="66579" checksum="CF001B6A6A0FD212" modified="2025-10-08" version="1">MTSLLGSSFCQAMMMMTMKRERSAAILGLVFVCLTAVLPGSRGADVDVQAELQELRDMIRTLTKLTMVQQEFIEERIRSDGQSGIKQLRHDTEGTRTYYGSTHIDYSTAAIHDHSDYVRAVGMGETIAVMNGVEFRTRHNDYRLVRASTTSNDFLATEDLDFPPVPPEVTDKDSVQEQIAELREWFLAFHNQNDSHRNYHDYFRPVLCYMEGMWINDTDSEMTEPFPSDRHFLDASSWEDLMTKVRYMAYTGLKDNLENLAFLPRKIMSVSDDGHPHIAQWLYRILCHPIQGDLPTRYLRQREDWSYSYPRGRNQKSVLASRGARFQISEFEEDKFTDFSLLDELMQGIPGVDNTPSASLARGYAGDLYPGNSSGQEHTLQEGFYHRWYKFARKGAMGSAFAHVGFSDEPLFMAVTSQERVVPLAAESCNNNGRQCVSHSTRVTYAMPLEVIYLTPLLSWNPYNISYNETAGTSRQDSRDGSTDSLAFLGSDSETYYRTPVDFFSGGSVEADVADTVRATVKVLDSQNVVRDVTASGTRVILPAIEGQEIRLRYPVPPIHMEGSSVWKEVNVIKDYLTENGGDDDGDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4A0</accession>
    <name>A0ABM1A4A0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable cell cycle serine/threonine-protein kinase CDC5 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940546.1">
        <property type="nucleotide sequence ID" value="XM_013085092.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012351"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF613">
        <property type="entry name" value="NUCLEAR RECEPTOR-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940546.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26084" checksum="26A2B8B7AA3E03CE" modified="2025-10-08" version="1">MESFSVPLVKFISGDFWSSVKMRQVRVLCQKTITPVQVLEAAMEDDNSIRKAIKKIRLTDCQGRDSWLEIFHEISFMDYASHPHIMKMDWAVKCKDFVAICMPLCSRGSLHDARHRLNREQLERCFVQTACALRYLHNRWAVHGDVKPANVFLDESNNAILGDLGMSRLLAHGQNRVSSKNVLGTKGYLAPEIQSDITVDPFLVSNCRVFYLVSLFICVFDLLKFNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4D6</accession>
    <name>A0ABM1A4D6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012368</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940613.1">
        <property type="nucleotide sequence ID" value="XM_013085159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012368"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940613.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="48568" checksum="AB5F75DC77DB012E" modified="2025-10-08" version="1">MLRGLWKDKEIVKDWCRAEGVYLPKEQNAKEIGQFRPISIINVTCKIFMGILAKRTVAYLQSNGYVDETVQKAGLPGIPGCIEHAFTIWDTIQEAKKNKESLNVVWLDLANAYGSVPHKLLMKAMDFFYVPQEVQNIMREYYSNFQMRFSTANFTTEWHRLEIGIAAGCSISVIWFILVMEMLLRSAECEEEAKVRSPKKAFMDDVTLLTRDGDTMQSVLNRLDKLITWARMKFKAKKSRSLTINKGKQKQLKFTIAGEQMPTVKEQPVKSLGRWYSGTLSDRSQGVEIMKQAENGLKAIDQTKLPGKHKIWCLQFALYPRLAWPLTMYEVALSRVEMIERKCNSYIRKWLGLPRTINTSSLYRHRGALQLPLTSIVEIYKADQSGQMVARLLSATQADTGCALLCIEWMLMDMQYLIRVQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4X9</accession>
    <name>A0ABM1A4X9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101862961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_012940908.1">
        <property type="nucleotide sequence ID" value="XM_013085454.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862961"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF378">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012940908.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45067" checksum="821B4BB4227F3E6D" modified="2025-10-08" version="1">MLLTSRKSKTFLTPVICLAVLLAAGKVLFDVRLSDLQSSLTGSRPPPALAYSLSHADTKTVLSFLDRLRADLETSLKTSQGESESQGGPLPTSHTEPKRYVLQEVKKRSRSYDSVIRDKSSAGNIVVSARENSRNEISPKLSDEEGERSVAEVLAKPLVNKFYFKYISHPRDLCSKSKTETIFVIPSGPGNFQRREWVRSRDVSKYVKVAAHKAKMLFFVGRPNKENVTIQRQLEKEAKTYGDMALLDFEDTYKNILTKHLSMLNWTMAYCSSAMYVIRTDDDARVDAAKMVSAMWSIRRQTENFVVGVQHVGQKPIRYNKHRYYLSLEDFPDPTFPPYVLGGAIGYPMTTVHLLYQAALRLRPVWLDDVFITGICTRALNVPVISHSNFTFVHMKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A576</accession>
    <name>A0ABM1A576_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KHC1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941055.1">
        <property type="nucleotide sequence ID" value="XM_013085601.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100533211"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="8"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="929"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="427"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="606"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012941055.1"/>
        </source>
    </evidence>
    <sequence length="979" mass="110529" checksum="5503FAE7BE712920" modified="2025-10-08" version="1">MAGENECNIKVICRVRPLNQSEERTGSKFVLKFPSEESIGIGGKIFMYDKVLKPTVTQEYVYNVTAKPIVADVLGGYNGTIFAYGQTSSGKTHTMEGVMGNDHLQGIIPRIVQDIFNYIYGMDENLEFHIKVSYFEIYMDKIRDLLDVTKTNLSVHEDKNRVPYVKGCTERFVSSPEEVMEVIDEGKANRHVAVTNMNEHSSRSHSVFLIHVKQENVENEKKLHGKLYLVDLAGSEKVSKTGAEGSVLDEAKNINKSLSALGNVISALADGNKSHVPYRDSKLTRILQESLGGNARTTMVICCSPASYNDTETKSTLMFGQRAKTIKNVVTVNEELTAEEWKRRYEREKEKNNKMKLIILKLEAELQSWRNGKAVPVEEQVDVKTAAMESEPPSQGQTGQVANQTAMQSSFIGMVSGGVSAIPEAEKAQMEEEKMKLYQQLDDKDDEINNQGQLIEKLKEQMLEQEDLITNSRRDYENSQAEMGRIQADNESAKEEVKEVLQALEELAMNYDQKSQEVDNKNRDIEALNEEISQKTVKINTIQTELDSLRDTSTHQKKRVVEMMSSLLKDLGDIGSVIGGNAAENKPNSGASEKLEEEFTVARLYISKMKSEVKTLATRAANLETNQSENNKKLEDANTELSDCQLKIQQYEAKMATLSETIKDVESKRRKLEENVDSLTEEVARFKANETMHATVTQKAQETSDKLQSEIQMKEALEKQMQSHRDQHQKQLSNLREEISDKQTLIDELKETNQKLTLALDKMQTDYEKLKSEEAEKANKLSELTLQMDKREQAKEDLKGLEETVAKELQTLHNLRKLFVQDLQNRVKKAANKKEEEEDEEAGGNVAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATMDRVKSLETALKEAKEGAMRDRKRYQMEVDRIKEAVRQRNLARRGHAPQIAKPIRPGQHPGGPPAQSTGIRGGGTAIPANGPAAVKDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6I1</accession>
    <name>A0ABM1A6I1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hephaestin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941767.1">
        <property type="nucleotide sequence ID" value="XM_013086313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855511"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="181"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941767.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45495" checksum="E5F0D5DE9B50AFA6" modified="2025-10-08" version="1">MTDELEDHEGTVSIGGRTTNSLRFADDIDGLAEQERELVSLIDRLGKTSIAYRTEISAKKTRLMSKSNKNITVDIQNISSAMRGLNLPRTALSVAVFIFLLTNVAEGAITRKHFIASEEIDWQYTNGDMSNLLDLNDQSSAEAFLRTSRDRIGATYKKAIYEEYTDNTFTQKKKKPPSRGLVGPLLRAEIGDTVEITYFNNASREYSLHPHGLFYLKQHEGAIYLDGTSGRRKYDDIVFPGETVKLIWNVTESDAPGPDDPNCIPWVYHSHLNTVRDTSAGMMGVMITCRPGTLDSNGKRKDVEVEYPLLVKIWDENLSWYIDENAGRCLSPSACQKLKEDEDEGFIESNYMAAINGFMFGHLPDLSACVGRKVAFYLVGMGNEFDIHSLHFHGQNLHYQHTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7V2</accession>
    <name>A0ABM1A7V2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">B-cell lymphoma/leukemia 11A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101856554</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012942526.2">
        <property type="nucleotide sequence ID" value="XM_013087072.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856554"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012942526.2"/>
        </source>
    </evidence>
    <sequence length="753" mass="81375" checksum="5B1A25F3E1CCB33F" modified="2025-10-08" version="1">MKIYTSPGSSTSSSSTHSQSLPPAPSSLSPIDLVVASPRSAMDHHHRSAPSAGSAGSASPYPVHAHNPFTSPFRLPLDTRLPHPTSLSPFPRPPSFDLDLINDYRLRPQFLGRPATGLEPPAFHHSPFDRARTHMSPALESPYDYYSMRLKQLASSPVATVAAKAQFSSAQPPTPGVAATPTSTKPESPCVEPSAAGSPRGVNSASLSSPGLALPPKLKSCEFCGKSFRFQSNLVVHRRSHTGEKPFRCPMCPHACTQQSKLKRHMKTHSMKPDGSTSPSDAAAAEKADDDDDEDEEEEEEEEEMEDEEEMIEEEMNEEEREVLERMKASKAAEEGAEPGEIRHDAKRIKLEHNGETKVEPEEVEEEEEEQPSDLSMKPKASSKPVESLLSEVMKNSGLTSIQTYNEAFQAALAESQVNGKDKAAEERAGSVKSGLSHDGEDTPRSASPKSPHPAAAKREKDGDKESDKSNQKEHVFLGATDLLSKGLKRDAAGTPTSWPSSVDSLVSGGMDPVAASAAYSRLHHPWLYPDNPVRLFFPGYPPRFPPHARDLSLSAEGHNGLSLSPSVSTASSALKSSSDSPSIPALFKPGLSSPPSFPTHHARHGTSGSSSSSPTSNLLLPSNGGGTPRKENRRNDTCEYCGKVFKNCSNLTVHRRSHTGEKPYKCSLCSYACAQSSKLTRHMKTHGRLGKDVYTCKFCQMPFSVPSTLEKHMRKCVENRNARLLAADAGDLSSEASNGEVNRSTDSTTGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7V3</accession>
    <name>A0ABM1A7V3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852500</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942527.1">
        <property type="nucleotide sequence ID" value="XM_013087073.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852500"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046689094" evidence="1">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942527.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20804" checksum="6E8E8BD2268B70CA" modified="2025-10-08" version="1">MEFVACLAEVSFLLVLVSQSAFSEGSPQRHVSLRTNLIKRMDGIQSQLADVTSNLMDLDSDLEKALYECLDIRSDLCEAIKIEAGLKDMGSLGPYWMAGKRSRDPQVNKYAGLLQELRRKRAVLKRLMKVFHGADNVLRSERKRSCTLNLGFHCQTEEISNFADMYDFLSSPLSPGKKRSVRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A815</accession>
    <name>A0ABM1A815_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942608.1">
        <property type="nucleotide sequence ID" value="XM_013087154.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850905"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038884">
        <property type="entry name" value="CFAP61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056299">
        <property type="entry name" value="CFAP61_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032151">
        <property type="entry name" value="CFAP61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178:SF8">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23150">
        <property type="entry name" value="CFAP61_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16092">
        <property type="entry name" value="CFAP61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 61 N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP61 dimerisation" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942608.1"/>
        </source>
    </evidence>
    <sequence length="1263" mass="141697" checksum="5292AF98F2825FB2" modified="2025-10-08" version="1">MATPISQDGEAEVITARRTESLDAPHIIKLVEPWTEKLFGRVNIVNVIEKAVLAITLNNKNEEIMGHAAFLDFPNLPDIDSAKWEDWFNTKYAGGQVNSLNALFLHYFVAKKEYAMGCAQEIIRTAFNAVPDLHFLFLSVPVGQFPDPSLAQAFKPMEKREDGQSDSSVLFVCRRHDHVPVLHIRQAFVEDHDDLTPIFNRQSDMLHNTYGDYFLAELIEAQDADMHCLVAEVEKTSYGFMSISTDVNLDVLNQCFELVPFNGLRKPHPDDITQPPPTPPATPPTAPAEDEPEQESLGSKSASTAAIDEGATEGVNGEKSLGADAVAESSPKGSKHSSRAGSPAQEVKTDHRLSDAGSPSMVCELSDYEQNIKEAAETVEKSSPLSQPMTPKELVPPSQKRFVPTYHGAPNAFSIQLFCVAEQYEMRSCDFLVKAFSKFPDRDFCIVTVPHMVPEFPLIQNFVRVTPKCPSVLPQELYVFHRSGLLKNLRVRPACTSDLEAVEKLVTTIELKENILEDLKQFNAARRDIDGTEIQAYVAECLDQVVGVAVVRREEEIEYIRSHYNIEDFIYYNHHRREDHGHLHHFVLNPVFSHLTKHFFKEILRLAHKTCLHYPLYPPYTTKENLENHTLVSGLNALVPVRTRRQIVYPKEGLGINGPSERVLKEFPPYALNHVNRKLVLEPKVTVNARIVVVGASDVGLAYLETLVYCPHLRFNNITLISPHGLPGDLPPDQLRDQVLSNSHCFSQSDYAQMALRTWVNVVYGKMTAIDRTKKLVTVNGSAIVPYDHLVLCTGRQYQVPCPTGADVLNDTTNDQLPQSPHRRYQGPVPGNLFLVNDAYDGAVMLYRAESQLLKGNKKIVIYGHSMDAFTCLQALLKLGVCGSDLTLVEPPMADKVSCFNNPSVEGVVRARLSAAGVTMYGDSYLANWNDGEMEDGEDIATVAFTTSGAHLRLECQAFFCFFSKEVDKDAFTAINCACLVYDGRLVINASFHTNDVSVRAAGTLTKYQRKYHCEPWSHANFNSKEVGIALASEMLRLFDPTLEPQLEPPEEPLNLIPIYRSPNVRTAVLPGDLHYLDVSKPCLPTDLLVQMTQPDYGRELVTGQAGGGQDYFRLHVNHYKSVENITCLAKQPFPADNFLCLFGVHERTINNLLSRFDEGLVKDFYKYLMEPWALAIYHDRFADFRDEIRELLITSPKEGASTLEDLARQLVDEETGLTSEQRKELMLAYVSTGAKRAVETRLLNFMSYNHYHLPFYAKPGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A823</accession>
    <name>A0ABM1A823_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101853257</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942620.2">
        <property type="nucleotide sequence ID" value="XM_013087166.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853257"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047432909" evidence="1">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942620.2"/>
        </source>
    </evidence>
    <sequence length="148" mass="16933" checksum="F101C059B64700DA" modified="2025-10-08" version="1">MASTTLWILLFLLAVKAEQICVRWTLYKCERPWCEAGTFSKEKYGYLAMPKGHEEVTAFQEGLASLNLHFRCHRCAFLNLIKHGSQCVDGMSLSPIKESNCYTVLKTQNENRGGGKICKNNGQNQKVIPIECDDKKYFFCQTKGKKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A832</accession>
    <name>A0ABM1A832_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101857512</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942634.1">
        <property type="nucleotide sequence ID" value="XM_013087180.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857512"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942634.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21209" checksum="5B1B6D40F9C811B8" modified="2025-10-08" version="1">MCRPLESDRSSICTCTSSVPPAHTAVTAALSLLLSCVLMWILACTSHFWARDGLFSVGLFATCVDEQCFPTDKDKALWASITLSLVSLACIVLSTLKVFLMVCKVRSRFLLWGAMVSAFFGGIVMTAAIIQFKLGLDPEHMGSVGPSWYMALTCALLALASGVCLAYAVRHWDLGTPCNLTYAALLDENEVGEVGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A981</accession>
    <name>A0ABM1A981_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013061</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943235.1">
        <property type="nucleotide sequence ID" value="XM_013087781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013061"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943235.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62083" checksum="1CA11C4EBCCED739" modified="2025-10-08" version="1">MSASRSFRVLLFLIVWILLLVIITNTPKYLPLTFTSFLSVQSGHAGGGEEQKGLWLLSDPSKIVPDEKQDVEEDKSTTTKGSRRIQTSDESVSGLRIQAERDSRKSRDQPSHVTEINTKQLHSFDSESNTLRNDDIVSYKTSSPSSNDVPNKNDTPTVNDTPFRNHTEAQVLESKHASSNSGIPKTTGKVFDDKLDLPRYLLPSRINDISSDKNEDEKYFIYRCDDGLMRFCGGWADRLKGILTGFLIANLTGRTFKAELLSFSCHLEKFLVPNVFNWSLPHSFHTKLERHGKSGDTAYLNMVDKSDFYGRLHLINFTNMIGPAKFAYFKANLDYIDGFKKSKIYSKQLSWMKNLSRDVVYAKLYRALFKPSSALQSRLDLFLATARPPGHRLICAHIRMGRNPSLPNDSQLRQTPEDLPAVWKHLKNQSHRFKNSKIFLMSDSDDVIQLAKNQSFAEKLVFTQGNVVHVERSKMVNAEEKCEGLEKVIFDQQILMHCDVLMISKSGISRMAAYVRQKDDGLFCLVKKEVVKCETKALKELYKVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAL4</accession>
    <name>A0ABM1AAL4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate receptor-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944041.2">
        <property type="nucleotide sequence ID" value="XM_013088587.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854205"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06683">
        <property type="entry name" value="PDZ6_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043545">
        <property type="entry name" value="GRIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227:SF2">
        <property type="entry name" value="FI03335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="242"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="501"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="742"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012944041.2"/>
        </source>
    </evidence>
    <sequence length="885" mass="94114" checksum="16964C33605B6D57" modified="2025-10-08" version="1">MPGWRPNCLRGSIYKDVPPPDLGDGENPYPGQDICETKKGSLVVQLQKKEGCGLGLTFAGGVDKGQRPYVSNLRPGSIAHRCDALLVGDLIVSVNGIRVAGLSHDEIIKVLKNTGPDVSLEVEYEMPDPGLQGGPVQTKCQDVVLDRELNSFGLTLRGGMLVERMRPHPLTVVAIRPGGPAHRQGSIQIGDQVLAINGYKVNHLSVSETLGMLSQCQHTATLTVSYTVATMDILSQSEPPVLIEVDRPSGVDLGLSLCPGVYEGKQGMCVEYIEPMGIADRCGAMQMGDLILSIDGAAVDVMSVAEAGQLLKSGGENHVRLELVPVTHLENCANRQSLYHNSSSLAPSFSSHTLPSLGPAGGKLTGGMSSLWDTSSVGATPFGTLNMRKRNTFSRGPDRRAISCMSIASSSTSVLSATNQVCRTEATEVMLSPEHRSVGLTLKAGGLGEPPLVTYIEPRSAADRSSVTPSSGTYVVKLAKRSGVAGIKVRDEDNEGCVVYTVELHRHGGPLGITISGTDDPQDPIVISELTPHGLAERTGAIHVGDRLLAVCGVPTRHRALSDAIRLLQSAGDVVTLKIARLDHSLRNGETLPPAYSSLSALKPSTPIASVDSAMESWPGSGQHLEEDTGHVMVLAVPQNAEGKRKWANGGYDHRAENLPQSQNLKEWETNSVQSVLSSVPGQQTEEEEEEESGSGLEDSDGGSSHMEEWVKTLEKLDMGSGSEMLKQIGLSLRQRSVLSLERSVPTADRPSLLDLPSSTVQGSRSSKPAVSPKRSRSACRVNETPDPTRRENSSAGRNHRLSLVGNNNSNNNNNNSISNKSRGRGGVAAASPVNKTKTTEAGCGTVVPMIQDSGSRLTLVVCRNPLLRLTHNMREEMVGGGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC44</accession>
    <name>A0ABM1AC44_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC106013507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_012944882.1">
        <property type="nucleotide sequence ID" value="XM_013089428.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944883.1">
        <property type="nucleotide sequence ID" value="XM_013089429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013507"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012944882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012944883.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53890" checksum="D8C95EC5D7D38C00" modified="2025-10-08" version="1">MKAVRGLFRQVAITCLCLGDFARLLCLQAGKCKAKIVGLFALVCVIFAWKKLFEGPAQMGVYFPHAVVMRSSPASSAPRSSIFSMTAGGTMYLYSAIANDRYPLDGETNVIITGLSRDGLPSHCCVVLDNTTIYTSLPEEFETNRRARFSELPVVRDIAWYFLEEPSRAVQVTCAVPNTGHRATHATLSFSACSQDTSGYLPVQRPSAPEGSMAVCAKIAHGNGLDPEKVIEWFELQMLLGVSKVLMYDLGVTDPVKRVLNYYQRLGFLDLQPYELVGPPRNRSLSEKFKRMPQFSHDETLSVYDCRQRLMDYTFVLGHDLDELVIPRQDVTLPEFFKAHLETYQDAAGFEFDTEFFIYNWGASSPKEDLMVTRFQRCTLPHRECTKYVYLPRRVHSVETHNIFPRKLYKVYRLPKTEAILHHYRRCPDDVWPTCEPDTIIDDVMMRYKHKLLPRVQAVRRKTDTKTQWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD35</accession>
    <name>A0ABM1AD35_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein LOC101858755</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101858755</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111670.1">
        <property type="nucleotide sequence ID" value="XM_005111613.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012945404.1">
        <property type="nucleotide sequence ID" value="XM_013089950.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858755"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="129"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005111670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012945404.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="63851" checksum="E7C976A376D51864" modified="2025-10-08" version="1">MMTAIKQEAVTEDYESQFYPQYEGHSTSLSTTSSFFSPELSASQVKVEAEEDDTSQSSSGVPPPPVKEPKKRGRPKKVRDDSGCSPDGEKKTPEKKMKQDTATDSLGVKKKRDRFNGMPEEEVLQRLLPDRLAHNLDIIIIGINPGLFAAYVGHHYAGPGNHFWKCLYLSGLIPEPMNAYDDFKLLDFGIGFTNICARTTRGSSDLKRVEIKEGAEILKRKILEYKPKIAVFNGKGIYEVFSGNKNFHIGKQPDKLERSDTVFYVMPSSSARCAQLPRALDKVPFYLGLKKLRDYLRGDLATLDESEVVFPTGALEQKPKAEVKDEGKELDEDEGSRSSLVCSKDLTLEQIQMQAEYQEALIASAEGMDFPEDVWSQGQSSFGRRKSGVKNGDIDYQLPGSFSPFDSAFQSSAVGQALSKSAQSAQSAKELGSAGSMGVTIKQEFPFNADEYESVAVKGPTAQKVNLDASIPDPYQCHISSSPQYISLGELPSRSKSAKKNDSNKEKSGGGGGRIAASSPSSNGQCSSSSSSSSSGKGSMFQHSHLSQQHSFTKILQSPFSHPDAGLLNLKQPKISDKGVRNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADF3</accession>
    <name>A0ABM1ADF3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier organic anion transporter family member 1C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101849578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945564.1">
        <property type="nucleotide sequence ID" value="XM_013090110.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849578"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF142">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="778"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="628"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012945564.1"/>
        </source>
    </evidence>
    <sequence length="817" mass="91235" checksum="26E37FB2E15F8C09" modified="2025-10-08" version="1">MSSFSGELDRSRQEMADFQQERERQRREQLEEVRELGQRLGQVASELRRLLEHRRHLPVFSDDDDDDDEEDGDLGGGKPLLRSSQHLPIKPHSADHSRATERSATPGQTATSSDVRETAERNGTNPFEDRTPDGGGGQNQPLLCGLYGWRPHWLQPFANLYMFATLVGLSYFFTGMARLSLRGQLVSIERQFNIDSSRSGLFTSAALFGHTCSVLLVGHFARSTNIPLAIGIAGILSGVFTMMPSVLELASPYKLAPIDTYTTMNTDHPHRNEQYICKLSTTEDLSTAVSPASLLPNSSLAETLESDLERSNKQSNILAYYILLVSLFLQGLVNSFRYGALPFVYVDDNVLDKTRTGVFIAISYVLAELTEPVGDVVNSLLSSIPVDLSRTSMKQDDPRFISAWWLSFLVFGILTIIVSVPITFLPRYLLPRDIQQKSLENAMVTFAVGEKAKPCLPSSSDEILYSQLSEEEDSPNSDAVDMTLTESRPSRHQVKDLTCMQMIKDLPRSVYRIFSSPLFALLAIEITIIYVPLLGVRPFSIKYIMFEYNVSMARTNFARGMSSAITHILGTAISSYLSTRIKTRLGYLKLILFTSVITWMMTPFYIVFGCDNGPIYGLSGQFGMSVDNSTASTCHCDPSLNLLSCGTDGHTYLSPCYAGCTDSNGTVFFNCSGFNVHNSSSQAEPGVCDVGCERNFILYNILQASQTFIFSMNNMPRHLLALRILYPEDRAFGNAFMHFAPFLASIPAPLLFGKWIESMCVVWSSDHCSLYNRDSIRYLTGGVEIIVCGLTVVTYLAMVFVCRWLDKKEMLKLRREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADM7</accession>
    <name>A0ABM1ADM7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartyl/asparaginyl beta-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101851095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945668.1">
        <property type="nucleotide sequence ID" value="XM_013090214.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851095"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039038">
        <property type="entry name" value="ASPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366:SF29">
        <property type="entry name" value="ASPARTYL BETA-HYDROXYLASE, ISOFORM L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366">
        <property type="entry name" value="ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="784"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="5">
        <location>
            <begin position="923"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012945668.1"/>
        </source>
    </evidence>
    <sequence length="1089" mass="127402" checksum="6BC21786A51539C6" modified="2025-10-08" version="1">MAKNKKGAAKKDKPSPPSQGEKSAQNGAQQQQQQQQKKKLAVAGGGQSSKAPLAQKKLAVQHSGKARSSPEKGRKAAASSSSSSSSSCGWCWLFVVIVSVAVVVPSVMFSQEIQQLEAYQEYVQPQLLAFQEFAHPHVSAFQELVEPQVAALRKFVLEQMEAWSSESQPNVPTEEPTPEQQSRQKREDADEEENSSRSQQNEQPQQQQKDSSRDSENTIKKSKDTPKDDLASSDGEMPKVESINVRATSKTDKQENAQADEQKKAEEQQKLREEEEKKKKKEEEQRLREEEEKRKKEEQRLKEEEEKRIKEEQRLKEEAEKKKKEEQRLKEEEEKKKREEQRLKEEEEKRKKEEQRLKEEEEKRKKEEQRLKEEAEKKKKEEQRLKEEEEKKKREEQRLKEEEEQKKKKEEQRLKEEETKRKEEQRLKEEEEKRKKEQKLKEEEEKKKREEQRLKEEEERKRKEQKLREEEEKKKQEEQKLKEQEEEKKREEQRVKEAKKKEEEQRLKEEERKKKEQKLKEEEAKKAEELRLKAENEKKEREAEEKRLKEQQLKEAEKQKEASRLKEEEAAAKTAREQQQQQKEGGEKKEEPPKTENRKVAKQSPNQKDQQPEVPKEGAGAATGGNEAGGSNVEVEKKEGKGQKETPVDPPPLERSTYQLSSVTSDADLKIAAKLDSADTLMNDDKLEEAIRVYDDILRNNIASPRGHYGKALTLDKLGFKYMSNEYLEQAIEFLNRVLVLPDVPHDLIKLAGRKLADRQQFRGWGGKAMKTFKWLTQQYPEDLELLKEFGVSYMMIGQNDRARDVFRQVLEKDPNSGFAKVHLGFIIKTKDQDLEKAVALLKEGIESREKGTQDGRFFLHLGDSLLRLGREPEARKIYQEAEELGLFLSAWQRSLYNVESLTGRPWWTPEQTGYKKFFKMLEDNWETIRDEGLAQLDSKTGSFVPEDENLRDTGDWKQFTLYQQGRKKKENCDKAPKTCALIDQMPDAKGCKRGQVKFSVMSPGIHVWPHVGPTNCRLRSHLGLVVPEGPFLRVVNETRVWKEGKVMIFDDSFEHEVWHEGSELRLILIVDFWHPELTETQKRRLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADY7</accession>
    <name>A0ABM1ADY7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Testis-expressed protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101847395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945858.1">
        <property type="nucleotide sequence ID" value="XM_013090404.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847395"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042861">
        <property type="entry name" value="TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47083">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47083:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012945858.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16349" checksum="0C0BD3740DE4FDC6" modified="2025-10-08" version="1">MKVLLVHIRTGYNKLLVHNETTKTLSSEDVEREVIWFMKLSWNLALQSKDDAFCMKELFNLCSQFLSLCPLDAACYSRNQNCQLMSCAACLQLVRGSEDKNSTQNLLEEVLQHVEEYRMAERRANNSAWSQSISCSLCSCVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE11</accession>
    <name>A0ABM1AE11_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013792</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945897.1">
        <property type="nucleotide sequence ID" value="XM_013090443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013792"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21219">
        <property type="entry name" value="FI19613P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21219:SF3">
        <property type="entry name" value="FI19613P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945897.1"/>
        </source>
    </evidence>
    <sequence length="657" mass="71373" checksum="F88BCE772AB8514C" modified="2025-10-08" version="1">MVIQRVTSGLTKDVLYIGSAVPLETSEGLEAVQMPLRSRYPVENEEMLQGMMGTLEVLPEGIHLKFKDDNKLVILFPYSSLTLCAAVRCIKVTNTATNETVPRFVSLSSPEAGGANSNKPAIFTAIARRSKGRQILECHGFITMSPRDALDLVQWVSMYDRKAKHGNYATVGSSGMGQQQATYEAASAKGDMSFRTDTASTPGFPVQLAPGAPAKANVPQDFINEPPRQGYFYSTTSAQVKKYSLQKFSGGAGAGMGGAGASTMGGASTMMRGGGGGATMGGASAMGMTGPPGEEFPPGALHLPPGGGEQFESRRHGYAASTYSAPAYSAPRPRPPFMVPVRHYRPVPMVMRPMMMPPPPAPHPAMYSMARPRFFSPPPAVERAHPVPYVIAAPHHPPPGFYERPSRRGSGGSSSSDRSSSPDSPRMNGKTSKKNGSHAHHNHHHHHRHDDDSSESSSRPRTPTADYDSSKGGRVSRREQHYMRQGYTTRERHGSPTRSAHGKGFRGGPPRGYVLVPTPYNQYPPGHFPPGHYPPTMVRARSVPPHGERGSLNRKEKKSKKSKKDRKKKKKGSSKREEKEETAAYDGLSDGVTGYTSELGGGPNQPRDFRRTENQFQHERAFSKSLAEEIRKSTKGGQNEVNAYSYLGDQQNEGPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFJ0</accession>
    <name>A0ABM1AFJ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106014138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946662.1">
        <property type="nucleotide sequence ID" value="XM_013091208.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014138"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946662.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="24885" checksum="A6311E38CEAAE4FD" modified="2025-10-08" version="1">MIRGRKEGSNYATWFIGFDHDESFALPPFPELQPQSPRPPASGRQTPASAEVADVLSSPARTPSGPAASTQTPLSGPPATATSTSEAGTETDWPDTVEACTATEPASLRHPASGAGNGGSVNGSGVNGSGGVVRPHSTTDASTDTEVGRDIRVPATNRARHLTAETGVATDSSLSAPDSDNTLVANGRRVSSTSSSPSPSPTPPFAKSGLSVDASTCPAPEGEGSRLSTLSPVPFSPTPQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG10</accession>
    <name>A0ABM1AG10_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin conjugation factor E4 A</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC101860001</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005091941.1">
        <property type="nucleotide sequence ID" value="XM_005091884.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012946924.1">
        <property type="nucleotide sequence ID" value="XM_013091470.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860001"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16658">
        <property type="entry name" value="RING-Ubox_UBE4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF16">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="974"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005091941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012946924.1"/>
        </source>
    </evidence>
    <sequence length="1049" mass="120193" checksum="2C5A314DE1C1340C" modified="2025-10-08" version="1">MAKSLESNPFAALFGTLEQAKEFCDETSKTVQTNASAESISATQPTTVESDVSKEIDMLAENIFRISLRSDPKQRSTRVNYFPDIAEVYKESPFMDSSNIGHIVFEVLMLDRHADTFQLNHQIDSERESVLESDTLENTEVLTYLYCCHRRCLTRQEEYQKSNCEQISAFLNECKSVIVQNAATCLQQPGLFEYQDFMSQFIELCVEEDLPTHDPQNFPCRFLHEVCQVIESSEDQASLSQALIPVLREVKGRLMATEMSVVHRDATKYCRVLHFFTATRALATVFMSQNTPEATQNFHGRTYENTPIGAALSLSVLPRYDKGPFQFFSKPSVQTKKEVDMVENSVWQATQQLIGCIHKIFVDLMKVSPDMKHYTLRWLGLCIQGNAGRAKLWANNLPSGLFVSDAFAVNLTHLLLLFCRPFSQPDSWKLLKIQPSYTTATANGDKEMLRRSLHLLGLQKETCLVPSEDAEKGEEEDTFNFITECFFITQRTLQVFLQPVIGRLLSVNRDLHQIQRLYNDIIQQSQGNEEPVVNIKSRMEKAMTIYINRKAALTQPELLSLAFKFQVASASWLSLAATKKLPRAAVVTADTEVPKIEFPLPEEPTPVLTCIPEFVMENIISLINHIHRFEDGVLESEGDNLQYLMTLVLVFMSSPRRMKNPHLRAELAEMLASLMPLSERHPEKGLAPQHFRQQLFETHPHIMQLGEAIMHVFVSIEMTGENVAFEQKFNYRRPMYTILKYIWDIPAHQEKIKRLAKYAEENILCSDPPLFLRFINLLVNDATYLLDEALMFMGQIKEKQQERERGDWSRLPEAQRHQEEANLQQISRLAQYHNVMGSSTISTLRMITGQIQSIFCHATFVDRIASMLNYFLCRLVGPKQREFSVRDKENYDFKPQETVSNISSIYVNLQHSDLFCQAVFQDQRSYSSELFSQACQVLERIGESPQAIHDFIQLDDKIKAMQSVKVSEEQALADAPEEFLDPIMGTLMTDPVMLPASRNIVDRNVIARHVLSDQTDPFNRQPLSLDMVIPQSELKARIEAWVAERMKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQW7</accession>
    <name>A0ABM1VQW7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101851257</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101851257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824809.1">
        <property type="nucleotide sequence ID" value="XM_035968916.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851257"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="entry name" value="PGBD-like superfamily/PGBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF323">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046568235" evidence="9">
        <location>
            <begin position="25"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="10">
        <location>
            <begin position="283"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="7">
        <location>
            <begin position="399"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="7">
        <location>
            <begin position="451"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="7">
        <location>
            <begin position="513"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824809.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="65001" checksum="EABA172B20BC7C74" modified="2025-10-08" version="1">MRWRRRQLVGSVLALPLLAVLVLGEPFYQRRDHLDQTKYLKVTNENVVKDRTDAEFVLSKYGYLRCHVTRRRREATHPRHRAMTSHFSSFLSSLAMVEEGGEETCDESEVQKAIRNYQRTYNLPETGELDEETKSFMSTSRCGNKDSEKDKSAPLGDEEALNVLVTDSQTAARAHHHNNQHSPVMDDGEDNFSSTSNGHRLWRRSARRGATSQLYKLLAGDKPTSRPQSAHRRHLQEYVQRLKRDVTGKRRLLHKYTARERKKRSVHVWTPNSLPLGKYIGENGELFNKDVVRWRLLTTGFSTRIPVEDQRATIDLAFRMWSEVIPLKFVEDTSSDIHSVDIEIAFGKGSHQNCEHDFDGNGGEIAHSWNAGNMHFDDEENFKSIRSYRQTGVCKGSFNTAFDWVRRRPDNQFIYNTYFFRNNHYWMYENHANRTRYGDPLYIAREWDGVPDGLDGYVHVWLFNGADVMDDAYFFKGELYYKYDSENDKVVEGWPRRISEDFGPKPDETEGVPDNIDSVFFDTRDKNLYFFKGEDVYVYNPIAQDEDKGCCVRKSKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR48</accession>
    <name>A0ABM1VR48_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Annulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101864519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824890.1">
        <property type="nucleotide sequence ID" value="XM_035968997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864519"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF40">
        <property type="entry name" value="HEMOCYTE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="3">
        <location>
            <begin position="369"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035824890.1"/>
        </source>
    </evidence>
    <sequence length="789" mass="88586" checksum="BF8AFA32DDB8B839" modified="2025-10-08" version="1">MFDRAKSQGSEPIPSSPNRLKATSMPRNTVYSGGLYGGHNGRSRLTDFVRTFNSRFPDSLTRHFGTNRVYVYGGERGNNDSAERGASSPPPKPDPVKVLTVRHVDLTVPANTKAHRTDEYDICGSHQERPKLVVRRGQPFNIQVKFSKPYDSKTDYLRIAFEAGDKPSPAKGTEVEFLLSDEDKPKEWGAKILKQQSNSLLVTIFTPPTCYVGKWDLKLNVFKKENSHSSVDVYRYEHEDPIYILFNPWCKDDTVYLDDEKLLQEYVLNESGRIYSGNSRQITSKPWNFGQFESCMLDVAMYLLEISGIQWPVRGDPIKVIRKITAMINFDQGDNGVLVGSWSGNYEGGRSPLSWTGSVAILESYWDSKRPVRYGQCWVFSGLCTTIARALGIPTRSVTNFSSAHDMDGSITIDMIVDKHGEVDEERSDSMWNFHVWNESWMARPDLPAGFGGWQVVDSTPQELSDGTYCCGPVSVAAIRQGEVNMPYDGPFVFAEVNADRFKWFPDATGIMKIVKKETNVVGKCISTKMPNSDEREDITHQYKPKEGSAEERAVVLKANQLASTKENVYKTTAQDVDFEVVQEAANTWVGEDFKVSLNLTNKSDAERTVSGRLVVKTMFYTGVLADKIVSVPFENKILKKGNSTVPVIVKAQDYLEKLKDCCMLDVSVWALVRETNQCFITKDDCRLKKPHLIVNAQEEAVKGREFKVEVSFKNPMDTTLTDCKVTVDGIGKALHFPQGNVAAKSAFVAKLPITPAKVGQKEMIFCFSSKQLEDINASKRIFVRSRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRW5</accession>
    <name>A0ABM1VRW5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ileal sodium/bile acid cotransporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101854013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825157.1">
        <property type="nucleotide sequence ID" value="XM_035969264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854013"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035825157.1"/>
        </source>
    </evidence>
    <sequence length="606" mass="66701" checksum="5E99D6043AFCD82A" modified="2025-10-08" version="1">MMLLQTYSPEDGIAVPLNSNGSGQNHSHVDWSKNLIVLHEQTEVHMNMGERKVIPVLIIATCWSNDVSYVLTLKSSNPSVGYFTGGQNLSFTLSCDVKDDSDPFYELEMKGFDHGVFAAFTQDKDTILTDFKSQPNAVRSVRRVIKLMNVSLEADLLGRTWLTFSSNQTSRDPAGGLTTTDKVEQTANISNNGLQNGNSPDGQTVHQIPVVVFRNMRPIDIIFRVVLYTCVALTSIGMGCKTDLGIVKEVLKKPVAPVMGFIAQYVCMPLIAFTVSQVVPLDNPAVRLGIFACGVCPGGGASNIFCYLLNGDVSLSVTMTCISSVSALGEEREREREREREREREREYAVDHSSQSMIPLWMFTLGQRFNDDKISVNVPFLKILQTLALILIPIFFGFFLNLKFPKVAAKVKKLITPVAIVTVVFILTVGIYSNLYMFRLFRGGTVAAACLLPYAGYILGGVLALISCQTWSRVKTVSIETGIQNTSVAYLMLTFSLPAPDSDLAAVGSASSAFMTPLPLLVVSVVYILYNKWKRKHANDQAGGGSEGDDDDEASSPMTEMLSSKEDKQGKELSLSLSLSLSVCVCLSLPLEREREKEREREREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTA1</accession>
    <name>A0ABM1VTA1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC118477684</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118477684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825643.1">
        <property type="nucleotide sequence ID" value="XM_035969750.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477684"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="3">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035825643.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19415" checksum="5F1F9B3EAA6D4C3D" modified="2025-10-08" version="1">MAQAAEPVTSGNSTEVEGRELVLFLLGKTGHGKSSTGNTILARPAFEVHYSKPYGRESRFPRTGALESLLKYQKKGALGDCNNWRGITLLSVPSKILAKIIINRMSDGVDSCLRKEQAGFRKERRCTDQIFALRNIIEQCTEWQRQLYVNFSTVFIEKVFGTFYDLMESLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTD7</accession>
    <name>A0ABM1VTD7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101861698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825679.1">
        <property type="nucleotide sequence ID" value="XM_035969786.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861698"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF101">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035825679.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28349" checksum="7EBCF92AFE64E6A4" modified="2025-10-08" version="1">MMFTRVISRHPWGFFQRNILQQAHQTKRLKATGIEKPPTYDEALSILKTFMMKGPGAERTTELYDVTASKYDQYVEVVRARTHSELAKAVSAVLGNNFQAKIIDVCAGSGLSGLWIHRAGYRNIDGIDVSQGMLDVAREKGVYGDLICQRLGDLPLPFDDRTYDMASMGAAYGENHMPMEALPHIIRVVKPGGYIVNVFREEALRSSIYGEGLDPYMKQLEAEGLWKEERRELFNYLIHDVVGIVLVHKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VV96</accession>
    <name>A0ABM1VV96_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101853627</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826338.1">
        <property type="nucleotide sequence ID" value="XM_035970445.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853627"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029415">
        <property type="entry name" value="Lines_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032794">
        <property type="entry name" value="LINES_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024875">
        <property type="entry name" value="Protein_Lines"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16057:SF1">
        <property type="entry name" value="PROTEIN LINES HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16057">
        <property type="entry name" value="WINS1, 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14695">
        <property type="entry name" value="LINES_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14694">
        <property type="entry name" value="LINES_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Lines N-terminal" evidence="2">
        <location>
            <begin position="545"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Protein Lines C-terminal" evidence="3">
        <location>
            <begin position="837"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826338.1"/>
        </source>
    </evidence>
    <sequence length="887" mass="98517" checksum="0E043A47A7367C3D" modified="2025-10-08" version="1">MDSAAMNIFRAVCHQENPQLLITPHKFCSDLFLSMHNHVNDSEICSPHSQVLFSSELGLPPCKLMVAVSMTAAVFNYCEYHHINAEKLKLRLSSTSASEKTSSNKDNGGLHIESVDLAQSVYQAKGEAASCQSPTFDQDFHNTIGNGLSVTDWYGQTLLFLLERKIVFTLVTLLQSKCQVIAYVARKTLVTGTRNNFFEVADVLSALETDIIQRTAEESSEVIDLLVQLMSFKSSNSGSVQSLTCKWIVNCVLGIQINITLETSVCVSRRMIGLLQLWKCVLKYLSQCSSDFAISKTLCLLFEEKLLPLADHFFQLEKPSLGHLVCIQYLKVISSMLSLQAFIPVSVHQTALFFLESSPSLFSCGRNSGLFNKTDFVGSSIDASESGLETVSTLTKSFILVLFEASAVLLQGRKACEVSQLVVNSIQFLLHNVCHVATPVAGSALSLDWLPTMFGDQDDKWISALFCLLKIWRYGMRHGWQEGSGREKDLHLAVLQNSAGGEKDKAQEGCNSAKQQNECLTSTGDLHCMAQTGPFQFQEVDLLRQISPHKLFLQFASFIDHDHLVLADFLTSPETCFLAYFTAYLHDLEKDWLNFTITCQQEEDSECDKTVIKHKNSTASLSVCQSPLLAPLQFFNENSKDNKDKNLGLEVLKTDDEVCPSSQHCPRQENVSFRKRPNGDLNFYMNNVTGLCSKETTATALNTAAKKPNLSLVVYTDSDSSSCADDAGDSGEEDSDINSMCSDENPEGNSLFGNKDSDKHSFCSDDNTDRNSLCTDENSAANILSSLLKDTKQNSEGIVKEKMTTKSLNMLTSQPEESAIKEQELHTIPQDKNIDHVMGMLIRLRYHVQRLSLNNLFPYNATPILKLLTSCENCYENLTDSSGYKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVK2</accession>
    <name>A0ABM1VVK2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BSD domain-containing protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826444.1">
        <property type="nucleotide sequence ID" value="XM_035970551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852253"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="148"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826444.1"/>
        </source>
    </evidence>
    <sequence length="741" mass="78122" checksum="8EAB54D8A1FE905B" modified="2025-10-08" version="1">MADGGKEQSPADNSWESWLGGWMQTAKEKSTSALEFVKNDLAEFTCTMQKETEKVVEKTSSQLKDSLNRENTAQATSKVKAGLTSFLDNISKVLVIPPDEDDEYVPMKVAADGSGLYDRGKARLHALQLDAGTYIDPPRCPPEQFAMWQESFDLDVHKGQISELLVSKVEVRALYTKLVPGEVSHLEFWQRYFFRVHQLEVDEARKRALMLRADQARGDSLGWDDDDWSGGEEDDGNHSDWEKLARPPQSQAASPADAAIAAATLKATPTVVASVGPVPEEVVQPVETRDTSQVSLESPGDLAGSDCVEGREEPASDRLAGDNGTARPSTAESVRSEQQGVQEKELPAPESCPSAEDKEDSCSTSKNDSDALGVSESVATSQMATSDLWSLHIPQDRDTASAAPSPQRPSPLKDTDSGSSSSTTSSASTQRGERSPDVSVVQQEVVSVCAAAAGGDVSSAEVRVTAPVSADGAACGAADVLTSSVGPQGERSSAEPEVGSEVTPSASVVAAAVRHVGQTEEEKSPPATSAPSVQQPGPSSAENSTAPPKPADSPTVPPPKPTETPTAPPPKPTDTPTAPPPKPADTPTAPPPKPADTPTTKVAEDEKRHQLTDVDTGVPQSGEESGQKMESQVEPAAAGVSGKEGGSGAVSSIAAPLSDQDVAEQMAMKVKGDMVVVGDRGSPSSESSGTKACGHNLGLEDEWDQDFDLELTEEDLKAAEDIAKRLGDNINDDDDDWENWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVM0</accession>
    <name>A0ABM1VVM0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101857459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826462.1">
        <property type="nucleotide sequence ID" value="XM_035970569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857459"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045119972" evidence="1">
        <location>
            <begin position="22"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826462.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35051" checksum="B6EC18FDFB5E9ACB" modified="2025-10-08" version="1">MLPPSTPITLAFVFLVGTALAQYDSDIVNKCPQVSPEDPNPDPLYYSHPDDCTKYVSCAFGLPYVMECPNGTVFSDVITGCVHEEGPYNKCAKRPENKATCQAGSRNLIPHPDFCQRYYNCSDHSDKRMSYLGKFEEECDYPDLFDYVLLKCMSFKVAKCAEGTKVGVQPCDYVRNQCVSSHCEPCSFRAPSCLGKPDGLHENTIKLWTPFHVRCESNRSVEFLECPFQPPDSRFRMLFSPERKACIPLWEIPKEKSGLQPDCAEKEEGRFFATDESDRVFYDCPFSKVFFCDKEEVFSEESQKCVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWV0</accession>
    <name>A0ABM1VWV0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase BRE1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118478061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826892.1">
        <property type="nucleotide sequence ID" value="XM_035970999.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478061"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826892.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35048" checksum="1E7F8044F742ED1F" modified="2025-10-08" version="1">METAATSSTSSSLPSIPSTPSPPSAGPRPYLDLESISAARARGYSTEQISDAIITFFYLTCGQFPDSPLLLGLLKAGTDNHKTLCDKTQENLDIRSENQVIKSEVEVIKSEVKAKDTEIQAKDTEIQAKERELQRQRFERHWRELAMKTELEQALEEKDQLIVEKNHVIEENRQVIEEKDHVIEEKDHVIEEKDQALHTKDLQLSMLRQELQEMRERQRPQSAPLDRSDFDSEDRSEEPDVRENQNSSRNEDVNLVTCQMCLDAPMQVLLRPCNHLCCCALCVSKLDGRCPICRRFTTDMEKVYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYR7</accession>
    <name>A0ABM1VYR7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Myosin-VIIa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101849950</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827560.1">
        <property type="nucleotide sequence ID" value="XM_035971667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849950"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17092">
        <property type="entry name" value="FERM1_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17093">
        <property type="entry name" value="FERM2_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13198">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13199">
        <property type="entry name" value="FERM_C2_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01381">
        <property type="entry name" value="MYSc_Myo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057130">
        <property type="entry name" value="Myosin_VII_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041793">
        <property type="entry name" value="MyoVII_FERM_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041794">
        <property type="entry name" value="MyoVII_FERM_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036106">
        <property type="entry name" value="MYSc_Myo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21998">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24123">
        <property type="entry name" value="Myosin_VII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="17">
        <location>
            <begin position="63"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="16">
        <location>
            <begin position="1018"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="15">
        <location>
            <begin position="1270"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="1577"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="16">
        <location>
            <begin position="1718"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="15">
        <location>
            <begin position="1874"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="861"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035827560.1"/>
        </source>
    </evidence>
    <sequence length="2184" mass="251143" checksum="A7B66573C0B00A4B" modified="2025-10-08" version="1">MVILAKGDHVWIEPDKVTEFSVALGARVVTSDSGRIKLVDDDGREHWVDGSRALRHMHATSVDGVEDMIGLGDLNEAGILRNLFIRYRDHQIYTYTGSILVAVNPYEILPIYTAEQIQLYRDRKIGELPPHIFAIADNSYSSMKRYQHDQCVIISGESGAGKTESTKLILQFLAAVSGQHSWIEQQILEANPIMEAFGNAKTIRNDNSSRFGKYIDIHFNEKGVIEGAKIEQYLLEKSRIVSQMHDERNYHIFYCMLAGLSAEEKGRLEVQDPWKYEYLIQGGSIECEGRDDIKDFADIRSAMKVLMFNDSEMWEILKILAALLHLGNVKYNEIELDNIEATEIQDISYINKVARQLEVDAQDLIDALTTKTIFAKGESVTYTLNKGNALDVRDAFVKGIYGRMFVWIVEKINQAIYKPKAGGGHYRKSIGVLDIFGFENFDKNSFEQLCINYANENLQQFFVRHIFKLEQAEYNLEGISWQHIEFLDNQDALDLIAAKPMNIMALVDEESKFPKGTDESMLNKLHHHHGSNSNYLKPKAAVNQRFGLSHFAGVVFYDCRGFLEKNRDTFSIDLVHLIQASKSKFINLLFNTDISMGTDTRKKSPTLASQFKKSLEQLMTTLSSCQPFFVRCIKPNESKKPLQFDRELCCKQLRYSGMMETIRIRRAGYPIRHHFAEFVDRYRMLVDGIGPSHREDCHRASEKICTAVLKNTDYQLGKTKVFLKDAQDSYLESQRELTLTKKILVIQKMVRSWHFRRRFLKMRKCIVTVQSTLRAYEERKRFLVMKQGYMRLQAMIRSRILTARFNVIRGWALNVQRFCRGYLVRQWVQKRMLAVVQIQASVRTLLAQKKLRRLRIEYEMKMEAERIRKEEEAALKKKMNAKKAKEEADRHHVARLQAIEREVEEKEQIQRMEAQQKKTQAEDAERRLNDPVNDSKLEVDYDVVVDDLFNFANQSDGRNMEGHEPEHFKDLKVAPGQSNGYIDGDAMPRMIEEEEDLTEYKFSKFAAMYFQGNATHTNIRKALRQPLLQLSSEGDQLAALAVWIVILRFMSDLPEPRYHTSMSETKDSTPVMTKIYSTLGRKFNKKDLEEAMRMGEEMEKEATNVSYSRNTGKKSTRKKIVSLTLRKRSKITEDVTHRLQHGYEGGVSGGGNALLEDRPMSNLEKLHFIIGHGILRPELRDEIYCQICKQLTQNNSNSSHARGWILLCLCVCCFPPSERLRPYLLNFIRGGPPGYAPYCEDHLRRTFANGARNQPPSWLELQATKSKKPVILPITFMDSNSKTLFADSATTARELCQQLSDKIGLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPKEDPVATHLIFQQVVRGIKFGEYRCDKDEDLAMISAQQYFIEYGTDVEPARLQTLLSSYVPDSYLQKGNAVNWWMNSIINKLHSDYFRNKQIEPVKVKEDIVSYAKYKWPLLFSRFYEAYKFSGPSLPKNDVIIAVNWTGVYVVDDQEAVLLELSFPEITAVSSSRTGKMHGQSFTLATVKGDEYTFTSPNAEDIRDLVVTFLEGLKKRSKFVIAIQNYENLSDPSILSLKKGDLIILDLDNGETVMNSGWCAGQHVNTQKKGSFPAECVYVLPTITRPPPEILNLFMQSGSLNDQFQAEEDVPRESKSAVLHTLEQYSYDHFRAPPKRTLSGTLNRPRRKRNEELWRHAKEPIKQPLLKKLLGKEQPSADACQCFMSILKYMGDHPSRRSRVANEFTDQIFGSPINNEILRDEVYCQIMKQLTDNRHEVSLKHGWELMWLATGCFPPSTNLLKELMAFLRSRSRSNNLADDCLNRLQKCLRNGVRKYPPHQVEVEAIQHQTTQILHKVYFPDDSDQGFEVESSTRAKDFCQNIANSLGLKSAEGFSLFVKIVDKVISVPEGDFFFDFVRHLTDWIRKARSVRENAPPPSFTYQVFFMKKLWIKTVPGRDINADLIFHYHQELPKFLRGYHKCSREDAAQLAALIYRVSYDEDKSNLSKIPEFLNRLVPSDLMKSQSAEDWKRAIVAAYNRDAGKSPGDAKVAFLMIIHQWPTFGSAFFDVKQTTEPNYPENLLIAINKNGVNLIHPQTKELLATHMFSKISNWSSGNTYFHMTIGNLVKGSKLLCETSMGYKMDDLLTSYISLMLNNLNRQKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZR8</accession>
    <name>A0ABM1VZR8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipid phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827911.1">
        <property type="nucleotide sequence ID" value="XM_035972018.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857513"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF174">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="100"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035827911.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35468" checksum="72F26C0CF3614BAE" modified="2025-10-08" version="1">MSNLPLTKQVVVDVFIFLAVCLPLLVVMVWGEPVQSGFWCRDESVRYPYKPDTVNTSLLLVMSFGGPFLVMTVTETIRAALKTRLPRRFRGELLSLAKAYGAFLFGVAANCILTDTLKFSIGRPRPHFIDLCKPNFDKINCTSDDLGLDRFVLDYECTNTEVDHRLLREAKLSFPSGHASLSMFSALFTIFYLQLRMEIKFSHLLRPTLQLCLIILAVLCCVTRIIDHKHFPSDVVAGACLGTVVAWLSFYKIAHKLIPTIVPDKQPSKAALARATSVESEPQTPTPLLRPERLVLNQGNNYRSSCPVSKADFANNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1Z3</accession>
    <name>A0ABM1W1Z3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106013387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828686.1">
        <property type="nucleotide sequence ID" value="XM_035972793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013387"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035828686.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="55635" checksum="0E12387B1A9BFF56" modified="2025-10-08" version="1">MSEGAMCCVPARHRKKMWVRVLMDNLLIILIVIAVGAGVGMGIGLREVWTHEDVRKIWYLGFPGRLLLNMLKMLILPLVVSSLITGMASISNSASGKLGGAAVLYYMVTTLLAVIVGIILVMSIGPGENTGKLRRAGKSTKAEPLDSLLDLISQCFPDNLVTASFQRRVTEIETKTFLYDNDTRSVTVDSPYLVSKSGTNVLGIVVFSIALGCVINNLGPQGEPLKAFFDSLNSATMVLVKIVIWYTPIGILFLIAGKFVETEDIGKVLSDLGLYMATVLAGLAIHGFVVLPLLFLVATRKNPFKFALNMSKALFTAWGTASSSATLPITMDCLVNKNEVNINVVRFVAPVGATINMDGTALYEAVACIFIAQVNNYDLSAADIIIISLTATAAAIGAAGVPQAGLVTMVIVLTAVGLPTEDVTLILAIDWFLDRFRTAINVWGDSVGAGILNHVFRRLFREQEQNAIELMVDSPDFNSNNSVSKTNEKEEDDDRPPSYNGVTNQAFEDTPNTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W368</accession>
    <name>A0ABM1W368_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Titin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101846321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829111.1">
        <property type="nucleotide sequence ID" value="XM_035973218.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846321"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
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        </source>
    </evidence>
    <sequence length="1444" mass="158758" checksum="286F5914E152768E" modified="2025-10-08" version="1">MFAGSDVTLSLGTAGFRSWGLVYLTLTAVTAVSLNEHTTGPVSGRHTDGVNKLSSKVIGQGEVTPAGQGVREQKDKRFIESTAGDILYRRAGGGGHSSSGSNLGPVVTHAIAPPLGPGVGFQPQQQPHNDAGAGRGPSRTGQKFTKFNDSFPERWVEWREEQANKRFLEEAAAERQGGGQIDGQDGGLDGGQDGGEIVTQDGGEEKRFLESIAGHIIRREEGGDVPYGQDGGREKRFIESIAGHIIRRGEGGASGDEGASGGEGADRTQEKRYLDGIASSLIKRQDVLGSDVAIGSTGNSGPDKRYLDHLGSSLVKKSDGQDKRYLDHLGSSLVKKSDGQDKRYLDHLGSSLVKKWDEGDQEKRYLDHLGSSLVRKSDSQDKRYLDHLGSSLVKKSDGQEKRYLDHLGSSLVKKSDGIDQEKRYLDHLGSSLVKKSDTEEKRYLDHLGSSLVKKSDGQEKRYLDHLGSSLVKKSDGIDQEKRYLDHLGSSLVKKSDTEEKRYLDHLGSSLVKKSDTEEKRYLDHLGSSLVKKSDTEEKRYLDHLGSSLVKKSDSQEKRYLDHLGSSLVKKSDREEKRYLDHLGSSLVKKSESPELARFEQRMFTDYNNDLVAMEKDFLEKNRELQQSSPDVTSQGNKRYLDRIGSSLVKKEDDEDTEVDEDGVGLFIDLEKDEDENDLRQMAGTRAGNHKRYLDRVGSSLIKKQAQAQKRYLDGIASSLIKKEDRGQKRYLDGIASSLIKKEDRGQKRYLDGIASSLIKKEDRGQKRYLDGIASSLIKKEDGFVGDIPNGQEKRYLDGIASSLIKKNELKSEKRYLDGIASSLIKKDNVQEEKRYLDGIASSLIKKEVRPGQKRYLDGIASSLIKKDSTNENKRYLDGIASSLIKRQDSVSDEEKRYLDSIGSSLVRKSSSTTPYKRYLDQVGSSLVKKGASEMGPYEVIPEAVYVGEGISAGGEGPVYVTIDGQLPILAMSETDLPMASPRKRMYEVTDDVMTGSGHQQLVDDMAAAIHVSAKWAGLTGTPSRQTHPRIRRDTPDTPTSHSAHPLTSSPAHSLTSSPAHLRQKRFIESIAGNILYKRTRPELSALHQGALVSDVTSPGPAQREAMSEPGFVDSPAGPGDDQSGGGNTHIGDNQFVTSTTEFDPFPGTTHFSVSPAHFSVSPAYFLDSPTHHQTRPLFETFSPPEVMGQGHVFQKRYLDDVASSLLHKRYLDTVASSLFKRLSNLPARPVGLGSGVPIHKRFTTESHRPLKAGNNRHMSSIKRYIDSIASDLIYRKRPRTLDLHRLRAMSPFQMANGELLTRPRDLAGSRERYLENNRGRTGHVSTVWSGRPTAMDAVRASGVAPGRESSKAYLREALREYVRGVATEVLDRTKVLGQSLTDGGQRGEESEEQGAGSQGEGSVEGAGSPSGWTNEKPGWGNEAYYSGQEETRDFFDSLAGGILT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1986-07-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>P01360</accession>
    <accession>P11923</accession>
    <name>ELHA_APLCA</name>
    <protein>
        <recommendedName>
            <fullName>Atrial gland and califin peptides</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>ELH-18</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName>Atrial gland peptide A</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>Califin-A</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>Califin-A large subunit</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>Califin-A small subunit</fullName>
            </recommendedName>
        </component>
    </protein>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1985" name="J. Neurosci." volume="5" first="1872" last="1880">
            <title>Structure and expression of the egg-laying hormone gene family in Aplysia.</title>
            <authorList>
                <person name="Mahon A.C."/>
                <person name="Nambu J.R."/>
                <person name="Taussig R."/>
                <person name="Shyamala M."/>
                <person name="Roach A."/>
                <person name="Scheller R.H."/>
            </authorList>
            <dbReference type="PubMed" id="4020422"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1983" name="Cell" volume="32" first="7" last="22">
            <title>A single gene encodes multiple neuropeptides mediating a stereotyped behavior.</title>
            <authorList>
                <person name="Scheller R.H."/>
                <person name="Jackson J.F."/>
                <person name="McAllister L.B."/>
                <person name="Rothman B.S."/>
                <person name="Mayeri E."/>
                <person name="Axel R."/>
            </authorList>
            <dbReference type="PubMed" id="6687446"/>
            <dbReference type="DOI" id="10.1016/0092-8674(83)90492-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1980" name="Proc. Natl. Acad. Sci. U.S.A." volume="77" first="2328" last="2332">
            <title>Purification and primary structure of two neuroactive peptides that cause bag cell afterdischarge and egg-laying in Aplysia.</title>
            <authorList>
                <person name="Heller E."/>
                <person name="Kaczmarek L.K."/>
                <person name="Hunkapiller M.W."/>
                <person name="Hood L.E."/>
                <person name="Strumwasser F."/>
            </authorList>
            <dbReference type="PubMed" id="6929554"/>
            <dbReference type="DOI" id="10.1073/pnas.77.4.2328"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 36-69 (PEPTIDE A)</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1986" name="J. Biol. Chem." volume="261" first="1616" last="1623">
            <title>Isolation and primary structure of the califins, three biologically active egg-laying hormone-like peptides from the atrial gland of Aplysia californica.</title>
            <authorList>
                <person name="Rothman B.S."/>
                <person name="Hawke D.H."/>
                <person name="Brown R.O."/>
                <person name="Lee T.D."/>
                <person name="Dehghan A.A."/>
                <person name="Shively J.E."/>
                <person name="Mayeri E."/>
            </authorList>
            <dbReference type="PubMed" id="3753705"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 117-173 (CALIFIN A)</scope>
        <scope>AMIDATION AT LEU-152</scope>
        <source>
            <tissue>Atrial gland</tissue>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1988" name="J. Biol. Chem." volume="263" first="9223" last="9237">
            <title>Proteolytic processing of egg-laying hormone-related precursors in Aplysia. Identification of peptide regions critical for biological activity.</title>
            <authorList>
                <person name="Nagle G.T."/>
                <person name="Painter S.D."/>
                <person name="Blankenship J.E."/>
                <person name="Kurosky A."/>
            </authorList>
            <dbReference type="PubMed" id="3379066"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 22-34; 131-152 AND 156-173</scope>
        <scope>AMIDATION AT ILE-69</scope>
    </reference>
    <comment type="function">
        <text>The atrial gland peptide A and peptide B precursors are the source of the 2 peptides that, upon release from this reproductive system gland, initiate the egg-laying process by exciting the bag cell neurons. These neurons, clustered in neural connectives near the abdominal ganglion, in turn release other peptides that act directly on the ganglion and also, via the circulating hemolymph, on many other organs to control the physiological processes of egg-laying. One of these other peptides is the egg-laying hormone.</text>
    </comment>
    <comment type="function">
        <text>Injected in sexually mature animals califin A excites LB and LC cells of the abdominal ganglion and causes egg-laying.</text>
    </comment>
    <comment type="subunit">
        <text>Califin A consists of a 36-residue large subunit bound by a single disulfide bond to a 18-residue small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the molluscan ELH family.</text>
    </comment>
    <dbReference type="EMBL" id="M29350">
        <property type="protein sequence ID" value="AAA27750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="J01017">
        <property type="protein sequence ID" value="AAA27742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A01630">
        <property type="entry name" value="GOGAAA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P01360"/>
    <dbReference type="EnsemblMetazoa" id="XM_013089680.2">
        <property type="protein sequence ID" value="XP_012945134.1"/>
        <property type="gene ID" value="LOC101851903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003424">
        <property type="entry name" value="ELH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02323">
        <property type="entry name" value="ELH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0027">Amidation</keyword>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0527">Neuropeptide</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000001800">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001801" description="Atrial gland peptide A">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000001802">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000001803" description="Califin-A">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001804" description="Califin-A large subunit">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001805" description="Califin-A small subunit">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="modified residue" description="Isoleucine amide" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="disulfide bond">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AAA27750." evidence="4" ref="2">
        <original>CS</original>
        <variation>PQLKTISNLLD</variation>
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="3379066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="3753705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="3379066"/>
        </source>
    </evidence>
    <sequence length="173" mass="19283" checksum="E71D0A340427B0B6" modified="1990-08-01" version="2" precursor="true">MKANTMFIILCLSLSTLCVSSQSTSVHGKIFVPNRAVKLSSDGNYPFDLSKEDGAQPYFMTPRLRFYPIGKRAAGEMEQSEGQNPETKSHSWRKRSVLTPSLSSLGESLESGISKRISINQDLKAITDMLLTEQIQARRRCLDALRQRLLDLGKRDSDVSLFNGDLLPNGRCS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1988-04-01" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>P62145</accession>
    <accession>P07181</accession>
    <accession>Q9V3T4</accession>
    <name>CALM_APLCA</name>
    <protein>
        <recommendedName>
            <fullName>Calmodulin</fullName>
            <shortName>CaM</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CAM</name>
    </gene>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Mol. Biol." volume="216" first="545" last="553">
            <title>Structure and expression of the Aplysia californica calmodulin gene.</title>
            <authorList>
                <person name="Swanson M.E."/>
                <person name="Sturner S.F."/>
                <person name="Schwartz J.H."/>
            </authorList>
            <dbReference type="PubMed" id="2258931"/>
            <dbReference type="DOI" id="10.1016/0022-2836(90)90382-V"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <tissue>Ganglion</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2001-05" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning of calmodulin from the individual identified neuron, metacerebral cell of Aplysia californica.</title>
            <authorList>
                <person name="Sadreyev R.I."/>
                <person name="Panchin Y.V."/>
                <person name="Meleshkevich E.A."/>
                <person name="Matz M.V."/>
                <person name="Moroz L.L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="function">
        <text>Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.</text>
    </comment>
    <comment type="miscellaneous">
        <text>This protein has four functional calcium-binding sites.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="X56888">
        <property type="protein sequence ID" value="CAA40207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X64653">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X64655">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY036120">
        <property type="protein sequence ID" value="AAK61380.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="S13248">
        <property type="entry name" value="MCGAC"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191509.1">
        <property type="nucleotide sequence ID" value="NM_001204580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P62145"/>
    <dbReference type="BMRB" id="P62145"/>
    <dbReference type="SMR" id="P62145"/>
    <dbReference type="EnsemblMetazoa" id="NM_001204580.1">
        <property type="protein sequence ID" value="NP_001191509.1"/>
        <property type="gene ID" value="GeneID_100533274"/>
    </dbReference>
    <dbReference type="GeneID" id="100533274"/>
    <dbReference type="CTD" id="36329"/>
    <dbReference type="OMA" id="WATHRNL"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000198243" description="Calmodulin">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand 1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand 2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand 3" evidence="2">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand 4" evidence="2">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N-acetylalanine" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6,N6-trimethyllysine" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="149" mass="16811" checksum="6B44A8917FC7027B" modified="2007-01-23" version="2">MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q8T645</accession>
    <name>Q8T645_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100533258</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2002-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chen D.Y."/>
                <person name="Martin K.C."/>
                <person name="Barad M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2003" name="J. Neurosci." volume="23" first="9409" last="9417">
            <title>An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAs.</title>
            <authorList>
                <person name="Moccia R."/>
                <person name="Chen D."/>
                <person name="Lyles V."/>
                <person name="Kapuya E."/>
                <person name="E Y."/>
                <person name="Kalachikov S."/>
                <person name="Spahn C.M."/>
                <person name="Frank J."/>
                <person name="Kandel E.R."/>
                <person name="Barad M."/>
                <person name="Martin K.C."/>
            </authorList>
            <dbReference type="PubMed" id="14561869"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF486842">
        <property type="protein sequence ID" value="AAL99981.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191497.1">
        <property type="nucleotide sequence ID" value="NM_001204568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8T645"/>
    <dbReference type="GeneID" id="100533258"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAL99981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="NP_001191497.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11721" checksum="8009F4F3B1A399B7" modified="2002-06-01" version="1">MTKGTSSFGKRHNKTHTFCRRCGHRSFHIQKKMCARCGYPSPRQRHYNWSKKAQRRKTTGTGRMRHMKVVFRRFRNGFREGTVPKPRNKAAAPASSAVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAW9</accession>
    <name>A0ABM0JAW9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101852808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005089483.1">
        <property type="nucleotide sequence ID" value="XM_005089426.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852808"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="60"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089483.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27832" checksum="2E551914F03DDD17" modified="2025-10-08" version="1">MASVFGRNFATGVKLVQGITAQCFTASVSTSSRLQTLSLVKNSNNTQRYFSTGCRLLSSVRVQQPAPDFQGQAVVDGQFKEIKLSDFKGKYLVLFFYPLDFTFVCPTEIIAFSDSIDKFKAINAEVVGVSTDSHFSHLAWINTPRKQGGLGGLKYPLLADFCKSISRDYGVLLEDQGIALRGLFIIDPTGVVRQITINDLPVGRSVDETVRLIQAFQFVEQHGEVCPANWQPDSATIKPTPEASKDYFEKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDU1</accession>
    <name>A0ABM0JDU1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101854922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_005091340.3"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MITOFILIN"/>
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    </dbReference>
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        <property type="entry name" value="Mitofilin"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="389"/>
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        <location>
            <begin position="485"/>
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            <begin position="180"/>
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            <begin position="193"/>
            <end position="203"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00010877"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
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            <dbReference type="RefSeq" id="XP_005091397.1"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEJ3</accession>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Exo_endo_phos"/>
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    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="91"/>
            <end position="324"/>
        </location>
    </feature>
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            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091913.1"/>
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    </evidence>
    <sequence length="469" mass="53469" checksum="5BD45E817BD2300E" modified="2025-10-08" version="1">MPDRSTGRGQTKRDPPTLQVSEVQLRANNPDWYKAYVTETATKRHHISVCDGPSESLGTRMNAGSESRKEAVCRKMEDLNTAKTKVIIGLWNVRTMYETGELAQVTTEMRRYGLHILGISESHWTGSGRLRTATGETLIYFGREDSQKREGVAIILKKGLEKCLMEWKQVNSRMMTLRLKGKHSNTSILQCYAPTNDSEDESKDYFYEQLQRELTGIPRHDLIVVMGDLNAKVGEDNTNYERKMGQQGTGTRNENGERLVDFCALNNLVIGGTLFPHRTIHKLAWDSPNGRDKNQIDHLMIGGMWRRSLQDVKVKRGADVGSDHHLVTARIKLKLKKTFTKEATRTRFNVHKLSDGNVRSAFRLELKNRFQALQDLEETPPPIQMKSIPNGSILLRPTQKAVRHVLVSRKRMQTKNGYSKELGILLKNEEKSRKDSLQLNQYGYKRSTQRIARKTGQEGQKRNHGNVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEL6</accession>
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        <submittedName>
            <fullName evidence="4">Hornerin</fullName>
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        <name evidence="4" type="primary">LOC101864366</name>
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        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        </source>
    </evidence>
    <sequence length="1840" mass="201777" checksum="58FF908551AD0C88" modified="2025-10-08" version="1">MSTSENSSIGARHEDESMDQIMADIEDFFQDDSDQSAYVASLDLDTRAMTSGDTASILEQNACTIGKILEECESLTASTSNSEQTGIEESGSVNEATSSSEVPGTSGVQTADRFIETQRKHPVVLLTRLSAEIISASQKVSSKGKGKAGVATKAKGTPTKAQETKKGKVYGEDDALSDLSVSDASLTDFAEFANSDEHDKQKKSSDFDGSSDILYVLGSACSQEGEASSSSGKNQGQNSSVKTKAQGKTSARPEKHKRQTEGKVEPANRKRKLEPSNSKQKDQISSKSAKQTKHVPESGQTQKDSQTTGDSTPLASPKGVSEEKCKQSEVPVKLADAMKQESKNHEPALKYKLQLSPIFIEDLANESFRKFINLALDCAVDFSKEMSGQIGTVSLYFGDDQGIAGAIQRLCQLPVLEGRERMCGLITYHALQYSKWRREDKRWKPHFWGRLAFDFHPSEAEKLQQLVQQKERKSENSKQKIAIIHRIPCSMGRKMLSPLFPYSVGIKIPEQKALYNGPVEVVFESEAWMNAVLSCFRNLCFHAKKDMQHKFFLLIKNFEVPKESLSDKSEHDRRPEVRGRGFSPGSSSRPGFVGGRSASGDRSKDRRDGTGQRDRSGQRKQGQSVFRQGGLQRERSMERKGRFDRPHQTSFRTPEKMSETASIMASNLEGVRNIAAARELDVNNPDVLRILEMQLQLETLHNITRRQAMEANSLGISVPHVIAGRGLGQGAELDVARENALRQGDSMRFLRDQRGHQEEVRDREALRLREARQREESLAQGSVQRLEEARRWNEARNVEEAKRRDEMLRREEAERQRVLLQEDALRREREKRQQDLLMASARKDFRQDHHTPRQRFQGSDYRNQVEGSSRQDSSLRGNGLLPTPPASGVVPAGAGAASSTTKTSSPFLSSKAKHDYGSRQRSTPSSRWTPQRTEDSGRRSQSSDKKSGVSPGPRQGQKDRSSQSKDAGQNQDKPSPFKRRSRWEDVAEPGQRAGDPAQKRRKQSRWETQEDGRKSAETAGNPVPGGVDPTRNDQPLTFGRPPPAKSVEDAVRDDMERSLKASSASKGASLAVLNQTHRGHRASAAAEEVLLPVQFGKNAEKKTPFVLASEKNKNEKLMGNRRDSKGWNPNAVDLGEASRPKFHNVADGQQRDFHQAGMSRGRGGVLNRGGQGGSPLSRGAFSTGAQRGRGVGRGERKDSWSEQGSERSWQRDEFARKGGFGPQKEQQQRPDKGRGGRFSGRGGFGAESAFRPQQEEEIPERSQFGGGYEHEQDGRGREGRSFFGESGGVHSRHAPDESKNWERDRKAEHFDPHSFAVPESRHSARDGQVLGGRKVANLPGQLGSRGGGGQRGRGVGRIESQREFFPKEHTGYGQEEHWDYDSGVHPEHGADAYLDRGRDGGREGEVGWDEEKEVRGGFPHPRPAQGGVDYGKPFGGGDGSLRGRGGGRGVPEPGREGSGLRGRGGRGGFMGRGGQAQQDSGRFHEGRGGRLDRGRAGLSNVSRGGHFEQGGRESFSEGSGGGLSNRGRGGYSDRGRGGVSERGKGGLPERGRGGLSERGRGGVSERGRGVFSNRGRGAAPPHGQNVVEREWGRNVQSSDHRFQAPAGSHSEDYGYGGEDQPQYEEVEGEYGYREKRGPPHEQRGSFGHQGQNFGSGGSGAHHGQDYGYDETSSSDLHFHGQDEHRGAAAWHETPDRGRGRGSQPPGRGRGVAASRPPQAGAARGRGRGRPSLLQTPPAASSQEYGEKGYGGEGDFAQYGGYEGGSYGEPSQYEHSYEGEGQKVGEYGKPFVADPPAVHHLRGRGVRGRTRPARGRGGSFQAPYPQSQSQQHLPMDSDIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF32</accession>
    <name>A0ABM0JF32_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092251.1">
        <property type="nucleotide sequence ID" value="XM_005092194.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852385"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005092251.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16182" checksum="B2E1E508E34D625F" modified="2025-10-08" version="1">MAKYIEKISNALKIVKHNGGIVGTYLGLYRRDDFKWGTFVGEDKYGNKYYKNDYFFMGKSRWVEYPLSVGHDYDASQIPSEWHRWLQYIADEPPTQLPLPHRPWMADHTENFSGTSREYVPYSTTRPKVEAWVPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFH5</accession>
    <name>A0ABM0JFH5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Charged multivesicular body protein 6-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101847246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092492.1">
        <property type="nucleotide sequence ID" value="XM_005092435.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847246"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005092492.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23662" checksum="F2A68AC931EA632A" modified="2025-10-08" version="1">MGNLFGKKQKSSPSRVTEQDKAILQLKQQRDKLKQYQKKVQVQLDKDREVARALLKEGKKDKAKLMLRKKKFQESLLTKTDGQLDNIEQLVHDLEFAQVEQEVVKGLQVGNSSLKKMHELLSLEDVERIMDETQEGIEKQREIDDLLSGGLSDEDETDVLAELDEIIKQSEASEVLNLPDVPEDNIGEPRTREKERQKEGKQAVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGD5</accession>
    <name>A0ABM0JGD5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuropeptide Y receptor type 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101850148</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093103.1">
        <property type="nucleotide sequence ID" value="XM_005093046.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850148"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="65"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005093103.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45041" checksum="CE7FE7943AAA57A6" modified="2025-10-08" version="1">MAFDLNNITSMLEMLDVPVSYQNFSLEELLSVSKEYEADNRWFSRDEELVIIVLFSFLSVLGLLGNGLVFYIIARKGWKQSSRNWYILNLACSDILTCVMCKPLTVVRLILKNWVLGGALCKVVPSLQTMYVFVSTFTIVALAVDRYSSIIYNNHQTRFKRWVFVCLCFIWLVSLGVSVPMMVVHDIEHVKGFNGNVLYSLCLEKWQSETAITSYTVLMLLLQYLSPLIAIVVLHFLIGRFLRSRFQTTSPENISVRRKRRRHRKNILLLSSMAISFGVSWFPLHFINALATIDYSFFQGLDFPLIHAVCMMLAFSSVCLNPVIYGLLNTNFRRDLIKMCGGGHEQRFSVYTDFTRRSSPNPEQLGLISSTPIEMGISNTNLCRIRNGHSISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGV7</accession>
    <name>A0ABM0JGV7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tripartite motif-containing protein 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101856497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093393.1">
        <property type="nucleotide sequence ID" value="XM_005093336.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856497"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF299">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="146"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005093393.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="62787" checksum="5487014244416F78" modified="2025-10-08" version="1">MTSTDNNAGNSAMANDSRGGGTGGGGGGATVAISDGGRALIVDEAYFEEQFLRCQVCNERFDQSERMPKSLPCNHTFCLPCLTQIFDHAQPPNRRTLLWADETLDGALKCPTCRVEIFLARIKIKELPNDHRVVQMIDFLSQAVAKSHNVCSKHERQPLNFFCKKCLVPVCRDCTVLDHKETEGHNITDVSEALNDNSAQFTEIENNSRLTLEKMKARSDALANASKSLDILDRRLKSEIKETFIEYRLLLEKRQEALTSMVHQIVKDQKALINTRFVEVCEHGTQLQKLYDEFKASKNSNDIRKLFTINQEMKDHEAKFTEVASQEDTELFQSCEFEAQNDCAFLTDMSSLGEVRQKADPGLKEPVSAHQLVYLDMEEQRERQRRIDNQIGNYGDCDEAFVRGANIEAGGFDHHHYEDSDEAGEAGEADDPRGDIPHLEVSRLISRYMREVHLHEDMEGHEGATGSRNRRSYDATPRRGRRNRDTNSSQVSSSLAMQSPSDFLRAARAAEVGNGSSSSSSSGYPRPGSRSRSGASTNYRVVRHQNAMRQQGGHSPEDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH20</accession>
    <name>A0ABM0JH20_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101862335</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093507.2">
        <property type="nucleotide sequence ID" value="XM_005093450.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862335"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="211"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="893"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="927"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005093507.2"/>
        </source>
    </evidence>
    <sequence length="1064" mass="121921" checksum="E5016D980C812135" modified="2025-10-08" version="1">MSMRTRIRGMTAWVNLRLNPYNQLMSNVLMDLLSGTGMKYLIESITGRDIGKLDSMDGLSQQQLQTRVEWVVEELKQCDVLPHDVYVDPRMFAMRSADHVFDLLWRLISHDCWFLWERVEYLQHEDQDVITQVPFKWTPDPPPYKKKKNKAKKSLLTGFGASAVMDDLEDSSSPDMNWIKFPKSEFMKNFKKKKVDPGKFPSPDVCILEMVNTQLKKTSEGKNLYCYGLGDLVDSRVLCALVNSFVPNTFTTDLLLNDRWTINLALRSAEKMFYAETPFDSEDLVEADGMAVASYFTFFFMVAYKYRQCQIVVERIDWIGRLIRECNHELEKFPPIVSNMQELQRRKELKSQIERHKEEIEKMVRRFDVEYCRRWVDHVQETQLEVRNYIRECIRNRFDYVTIPRNITINDLCLSYVINLSLSNGSGFYLSDAREMLTEGRHLVLRHKDTGEFLDDFTSKNKPSIKQILGLPKTNAVEINPLHYPQYEFYYEAPSRNKHLKAGTVFLYQVFPGNTSNWQRMFIKAARENEIETVEKMITFFKNNPSFINSKEPKTGHTALHHAARHGHFDIVRLLLESGANVDAKNNFRCTPIYSAIEGLQRQVAHLFIEWGCNVHTKNAKKLTPFEVVKNDEFRQFLVGLYEHYSSIVPKIMKGDKELMEKVIRDHISGKKEFCCLRSRCINGSTLLHTASYYGYQDIIKDLLQLRVDINLQDYKGAAPLHRAKDHETMLILMDNGANISAEDAEGNTCLHVKCYGEIEKPSEMDCIELLLAREASPVKRNNRSLLPIHCCAMQGRVDAMKLLLDYDKGDSILKSLNNESDRNPPSLLHLALANDFLSCAEWMINKGFHFKDKEVDILLRRLLTEQIKVSDRALAVDFLLHNGADPNPIYPGGNSSLHYAASLSGSTDVLELLLSYEAEVDVLNNDGSSPLMFACQANNQYAACVLINNGANVRQKNIHGLTAFDHIIDFEEWIHSGYFSDEITARLKAYSLKHSRDLIRAITKRVKPMSGPRGDAPHSALTLASGSRRSSPANWSRSPISERSPLSITSPLTVLPAIGSSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH74</accession>
    <name>A0ABM0JH74_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101862336</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093594.2">
        <property type="nucleotide sequence ID" value="XM_005093537.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862336"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093594.2"/>
        </source>
    </evidence>
    <sequence length="608" mass="68198" checksum="43FAE8FCA1C8467E" modified="2025-10-08" version="1">MAEDRGQWGRQLEFILTMIGYAVGLGNVWRFPYLCFKNGGGAFLIPYLICLILLGIPMFALECAFGQYGGKGPLTVWTINPTFKGLGVSMVAASCIVFVYYDIIIAWSLRYLVASMTSTLPWIDCHDCSCLLYNKNVTEDELEVLRYNNSLGYPCLNISMDNSASSPSELYFNEEILNKSEGIGTAGDIQWELLVANFVAYLVIFLVLLKGIQSLGKVVYFTAVFPYILLTILLVRSAMLEGAYDGIVFYLTPKWDRLTDAAVWSDAAVQIFFSLSACMGGLIAMSSYNRFNNNIIRDAFMIPIINCLTSFYAGFVVFSTLGNMAKIKDLPVGNVTQGGPGLAFVVYPEAISSMPVSTLWAILFFFMICILGFSTQFSAAETIMTSILDEFPAFFKRRPRQVLFRVSVCMLAFLLGIPMITQGGFHLLNLVDEAVLGFPLLFIGLLEYVAIIHFYGYENFALDVKSMLGFSPFIYFRATWTVISPVLLTAVIVFKAYQMEDIAPAWSGLIYYLIVIFVLMWVPLWFFYYSCKRGLWEMMRPEKEWTSRRQLGNGGTGEAGLDENGLAIDKKPNGDFSDRGHDNQSFQKDTYTNEGDYTKNGIENATKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI85</accession>
    <name>A0ABM0JI85_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine palmitoyltransferase small subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101847092</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SPTSS family. SPTSSA subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094237.1">
        <property type="nucleotide sequence ID" value="XM_005094180.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847092"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051900">
        <property type="entry name" value="SPT_small_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47084">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47084:SF1">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005094237.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9640" checksum="B4E1A4897092B919" modified="2025-10-08" version="1">MVLQKAYDRFSYWYFSYTILSNVYFLEPVERWACNAMLVFFLALVLYTSYVYLPGHSVMMLHFFRYLFGMETESDVTVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJB1</accession>
    <name>A0ABM0JJB1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">DNA polymerase delta subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101848277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094952.1">
        <property type="nucleotide sequence ID" value="XM_005094895.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824740.1">
        <property type="nucleotide sequence ID" value="XM_035968847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848277"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824740.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12637" checksum="D9506CECD0506F2C" modified="2025-10-08" version="1">MNRKPIVQVNDAFPQRKRIAHQSRDQVKGSSSKSVAQIHSKAPKELEVLKQFDLTLEFGPCIGISRMERWQRAQNFGLNPPVEVRDIINQHSDDEIYTQCLWNDYSSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKC8</accession>
    <name>A0ABM0JKC8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101854404</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095744.1">
        <property type="nucleotide sequence ID" value="XM_005095687.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854404"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045116340" evidence="2">
        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095744.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21058" checksum="F72D1BA92B37783C" modified="2025-10-08" version="1">MSAQCVSLALVALTIVVTSPILCLVHKEALDNLVSQKCVDKVTRCIPSFLQRGEDQCNDVKNARFCLNSGDECDAEANQKLDYVSCVIDRAEDEMAGASEDCKRHFRTCFSLGESLRNAKGLSNEQVKGRLCGYVRERENCFTTKRRGFSCTQAEYSGLESALCASAGRAIALSALIFMCLAISFQFIFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLY4</accession>
    <name>A0ABM0JLY4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101856886</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096779.1">
        <property type="nucleotide sequence ID" value="XM_005096722.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856886"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047395328" evidence="1">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="62"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096779.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19527" checksum="303A485670B88431" modified="2025-10-08" version="1">MEKKSATLLFSLAAIFLTAVEVLSISPNGVQKMKIVDMKVGDKNVPIMDNKGHASNCGKVPFNMTWTPKVLKSSGEVKVHLEYTSPHDLSSGFVNASVFFYGDSEPFLGYSSGFTCDKVKEYFPCPVKKGDRVNKTEIISNIRAISSYLGEYVAVLKVQNQDRQEMVCVNLTVTVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMP1</accession>
    <name>A0ABM0JMP1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101857638 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097283.1">
        <property type="nucleotide sequence ID" value="XM_005097226.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857638"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005097283.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31110" checksum="981CCBC7E5A61CB5" modified="2025-10-08" version="1">MCLCCAEWRESSTFLRSDRGTIMRSLYSIGLRHQAGLGCERTRVHHQRTPQIMDRTWSHRGVSYRVCLVSLLVGIWPFLLGFGAPDWLWFKKSGMNGTEMDGTFGLWELCVDNQCSSNPVIGNEVVDDWFIVVVILQTLALPFYILALVLALLQNFTPRSWLQSMRLRRLRLLLHRDSETPEDLAFVAGFLGFVGIIVFMIMTSEEVSHGAYYSWGFAMSFTAASILVITGVIMCKTHSPALPSPTQPSEPRVVHTMAPAAAARAGDPREPWWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMY7</accession>
    <name>A0ABM0JMY7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuropeptides capa receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101858935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005097463.1">
        <property type="nucleotide sequence ID" value="XM_005097406.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858935"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="63"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005097463.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43093" checksum="685747040FBB67F6" modified="2025-10-08" version="1">MSETALAMTQATEHTQSIYKGINDTSPIKEKNAELLSDEVAHLVMQVLMFYATPTISVLGITGNVFSMIILLKHGLHKCSNILLFCLAVSDTTFLVAFNSVPKILNEVTGVPMAWAYSRQAAHASYVFYTFFHIVDYAAGLSSLAIPMLITMERLVAVYFPMKFSVIVTPFRTWSAVAIVYAYWLVVYIYSSFWFEFQYKYDPKLNISVGIIGRSDLYYEEVEVSKALDEVIRYLTLKIPPGFTLVGCILISVKIKLASVKRQKMTSAGAAKDAKSNRTSKMLLAVCAMYTVTCGILALPTYLPQYGYYTMTGDAPNNVGRIGYQVVNMVVCINGSCNFIVYVGMNKNFRDTWKSLFTRCRFKRKPAPQSQKGQAQKRFEYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNS5</accession>
    <name>A0ABM0JNS5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase I subunit RPA43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098009.1">
        <property type="nucleotide sequence ID" value="XM_005097952.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845770"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098009.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="37892" checksum="700A7721ACEEF5E4" modified="2025-10-08" version="1">MGTFVKNLRKHIFLHPKDKLSKNVAVKQTLLRDQKKYSDRLEGALLNVSDIKVIGDKHLIVDGYLSMMVIANFHVFCPQPGMELEGVVNKRSRSHLGCLVMEMFNASLSVPGGSGLDPAVGDICQFEVTEVVVDGEILFMRGILKSSRPGPASKPQEEAEENEAEVGVEGGPQEEEEVPSAPAAADIDDDMLQDPPQTENPPEAGQNKGQSSEKKRKRKSGRAEAKASPEKKGSKSLKSPERETPSSRLKSASEPGEAEEPTAHHIIVKTEPRGEEEEEEEAPSEDLAGNMIHRTPKSPQQSQGNESQDSGKKKRHRKSSTSETKLSPEKKVPKSPRSIKKEKPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPE6</accession>
    <name>A0ABM0JPE6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_005098438.1">
        <property type="nucleotide sequence ID" value="XM_005098381.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846651"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="8">
        <location>
            <begin position="34"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005098438.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54192" checksum="194E1FD166DD9DEB" modified="2025-10-08" version="1">MQSVRRSSSLIQQAKLLPRVSWARSVWTGQEGIQEDDPEIYSIIQKEKFRQANGLELIASENFASRAVLEALGSCLNNKYSEGYPGARYYGGNENIDVIERLCQSRALEAFRLDPARWGVNVQPYSGSPANFAAFTALLEPHDRIMGLDLPDGGHLTHGFMTDTKRVSATSKYFESMPYRLNPQTGRIDYDKLFETARLFRPRVIIAGTTAYSRLLDYKAFRQICDEVKAHMLADMAHISGLVAADVIPSPFEYADVVTSTTHKTLRGPRSGLIFYRKGVKSVDKKTGKEILYDYDKTVNGAVFPALQGGPHQHQVAGVAVALKQAMQPEYRVYQQQVLKNAKVMSQALVDRGYSVVSGGTDNHLVLIDLKPKGTDGARVERVLELCFITVNKNTCAGDKSAMIPGGLRLGAPALTTRGFKESDFEQVVALLDKGVQLTLEAQKTTKTLREFKAFVLEDDETQKKIAALKEEVQNFAKTFSMPGFDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPF7</accession>
    <name>A0ABM0JPF7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polycomb group protein ASXL2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101853554</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asx family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098467.1">
        <property type="nucleotide sequence ID" value="XM_005098410.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853554"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026905">
        <property type="entry name" value="ASX-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024811">
        <property type="entry name" value="ASX/ASX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578">
        <property type="entry name" value="ADDITIONAL SEX COMBS LIKE PROTEIN ASXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578:SF20">
        <property type="entry name" value="POLYCOMB PROTEIN ASX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13922">
        <property type="entry name" value="PHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEUBAD" evidence="11">
        <location>
            <begin position="155"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="331"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="425"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="566"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="656"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="721"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="918"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="441"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="984"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005098467.1"/>
        </source>
    </evidence>
    <sequence length="1192" mass="123832" checksum="79C00E03CCB6634D" modified="2025-10-08" version="1">MRDTYGCCLKILKFIMEMENQSLKDNSISASLVPSRRSVRQSMRNKKYKFDPSDFKPKPRASNLSTVTKTNGPTTLSIKTDDVFTMKSSDCSKTLKISNGPQHMSKTNSKRCFPTLFAKGGMKFSMRPRKRSSKRSKSVAAQIEQTKDGCIDMTPDSILCKTNLKGLLNYKTFNQLPSSYQYKLVTLLPQCDQIPVISPDDLRLSSTALNNEFFAKACGEWKDRLAEGEFTSDNQQRLKLEEEKEQSKMDAWKAKHFEPVWGHSKLLSDVPKATGPSPTQLGSHLEQFAAVPKASKPTTILKSNMRVSSMIQKRHLSRAIRASVESALPAAKKSMSNSARSEATPSAPAANHHVVSDRSSASPLPASASSASESSPNSTSSTASSNNSTLDSAIAASREALARQVEKLRSEDRTEILGVTPAKKRRVVGSAGGPSAVRLPQQTQAQARTLAQIRAQTQAAKNNNKNMNVLPPSSHSKPASASSSGSSQGITRTVTMTSTGIIIKTQGQTRTLAQIKAQTQAARANSVAASTPGGPPAQSNQAMRSLLASGPLCKVAPTQTRTLAQIKAQTQARAPIQPQVIKPPSSSNLLSSELSASSTSGLTPQQQHVPNILSSTNSKIRASADLQSSASDVNLKRSIQICQAEFKKSLTKSATVIGTGGTTSPGPNQTPPPPPSPLPPAASQTVTPPPPSQSPSASKLLFPQSSLISAQPAGQVSTLNVSNGRVSGVPSPQHHFIQPQSPAKSSSRSATPTTLVINRGRVSPATTAKFVSLPCSSVNSGTHAVDTGGSKIFLVSPANKESGGAVLLLNSNSNQTIGASVKPQHSLGGGGSGGSVGVVKSLGAASPSGLPSSNSLSSAISPSTSVAVASSQVPRRLLTQDALRAFLNAPPRAASAPPNNATNTKVETPTTAAIVRSASVGNSGGGLPPQSSAPSTPSPTAPTPPPHQTFTVSLGDLPQGITIQNFNNPGVIPPSSASSSSSAHTANNILIPNPNQIRVISRSSSSGSPSPIPASSSPSPGVSGTFSVHKVDLSSLSTAGTPTIPTSIPPLRFSPSPIVPVSNNASQSISGKKFGTARIIHVSGPGGKLLQTSAQLGSPLKVGNVVNIQPMVSSAVTQQATAIKSATVLGVQPSQAPCEHQAGLPSDQGSDSVGSGCACNHKAMVVCKKCGAFCHNDCIGPSRLCVTCLITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPK7</accession>
    <name>A0ABM0JPK7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Elongin-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098556.1">
        <property type="nucleotide sequence ID" value="XM_005098499.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855255"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01788">
        <property type="entry name" value="Ubl_ElonginB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098556.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13557" checksum="5F0980F81506BA25" modified="2025-10-08" version="1">MDVFLMIRRKKCTIFTDAKESTPMSDVKKIIDGILKVAPENQRLFKEDTPMSDDHKTLADYGYTSTVARAQAPATIGLVFRQDDGEWESLDIHPLSSPPELPDVMKPQDANQAHQQEANAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPS1</accession>
    <name>A0ABM0JPS1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 22 member 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101859570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005098669.1">
        <property type="nucleotide sequence ID" value="XM_005098612.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859570"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="101"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005098669.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="65793" checksum="E46979CC7A783EF1" modified="2025-10-08" version="1">MPPKVGNVDAAFETLGPLRRYNMVQYCVLCSSVWSAAMNMFSVVFTGQHNPFRCRRTPSIFNDSKFKDLTYWNISESDTKEKFDSTCNINVFNGGIGNTSLASNSSFTEKCSAFDVEYLYPKDMYFVSEFHLVCERKYLIGISQLTLTAGQGIAMLLFPYFTDRYGRRPVLLLCCALLCASSLGLACSVNYGMFVGFKFLIGFFLQGMEAATITAMMETLVTRHRAFLFAFIGCLNWSFSCLLLTPVAYLLRNQSWRILEFTIAAFSVKIIPISLLFDETLRWLAANGKDERIMEVLKRASRWNGVDVKRVIDAFYTSDTKDNDSDNKGVFVLNVSHSNTAKYSNVPLPNGITPRKDAPCDLFKDPMLRRHTLFSVVAWFFNSFTYFSLILMSSTLHGTIYANYSLNIVAEMPQAIFCYFYLDKIGRRRVFAFFSIIAGVSLTVVATMWELAPDQKIAITALSIIGKVGITGSFNVIYLYTPELFPTNLRNMGLGLAYLGARLGGMLSPFAELLMEKIVYAPGLVFGISSLAMSVMPFFLPETTKYQLPQSLAEMKLWKRPQGGAAPRRCVPGQTDHQKTEDTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ20</accession>
    <name>A0ABM0JQ20_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101845692 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098870.1">
        <property type="nucleotide sequence ID" value="XM_005098813.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845692"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098870.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17539" checksum="AF55A360F0D29ECE" modified="2025-10-08" version="1">MASFYPLKAVILWTMAKETKHFYMKFVHREGNEVHTCYVADYFGDVGVMEGPTPGRIQELETQDREKAAAIETTVNQIFKTNNINGTFERLVAREVWHKILEHAQAVKANMIVMGSRGMGKVRRTILGSVSDSVLHHAHIPVLICKHPDEQQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ41</accession>
    <name>A0ABM0JQ41_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101856344</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101856344</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098918.1">
        <property type="nucleotide sequence ID" value="XM_005098861.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098919.1">
        <property type="nucleotide sequence ID" value="XM_005098862.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856344"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098919.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21667" checksum="2AB98517A4E2667C" modified="2025-10-08" version="1">MSFNNTEQIGSTWSLDSGLPISRENSPCLQHSRHPQQPLIIEAGILPVGNHISDAVVATFEGEENRQSQHKWLIENGQRIGSVTVQALHLQTPDNGQRPLCNGHGLPISPPDPKFKIVVKNLAGKSFKPWVKSTDTVLHLKELANQQWGIDRDQQIHVQLVYGGHKLEDDKTLGYYDMRDTDGEVQLITRLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSA5</accession>
    <name>A0ABM0JSA5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101861444</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100372.1">
        <property type="nucleotide sequence ID" value="XM_005100315.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861444"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045905141" evidence="1">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100372.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11553" checksum="9B603B659F002329" modified="2025-10-08" version="1">MASVSTTQSLVVLAVVTLAVGTWANLLNEDLPAGTCVCSTADTALNKRPGFVHPAVMYLLHDKCLLTHGNKTEIWGDAWYTIEVDEVLWGAGKTLAKGAIRQGVCGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSW0</accession>
    <name>A0ABM0JSW0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cilia- and flagella-associated protein 77 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101860979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100719.1">
        <property type="nucleotide sequence ID" value="XM_005100662.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860979"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029147">
        <property type="entry name" value="CFAP77"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28617">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28617:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14825">
        <property type="entry name" value="CFAP77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005100719.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30388" checksum="F8E19ADAEDBABC6C" modified="2025-10-08" version="1">MATQMEGPFDFTATNVLGDQRNTMLYNELHLRDKVGSVKTRGFELPGKHFTYGLPNDRRDYTAAHALRGWTGTYLPKGGATKSKSATERDFMSLNRASIAAGLVKAPENSDYRATHDIRRLPFDQKEMAGKMRSRRLPPTMVFGIPSRPSTPIFDLLEHKYQDKWIKDRQHQLSAQRSAEIKKRAMSAPAASRGTGIIYETRASLLRTYQNPVEPAPLWQLPRFTKSAKPHIQTFRTNRAKSDAFGNLETDKIARQGDFGTGIYEPAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTJ4</accession>
    <name>A0ABM0JTJ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Seven transmembrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101864630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101153.1">
        <property type="nucleotide sequence ID" value="XM_005101096.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826360.1">
        <property type="nucleotide sequence ID" value="XM_035970467.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864630"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005101153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035826360.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="44844" checksum="4F940B905BC8869A" modified="2025-10-08" version="1">MFVSLYPVYTKQYFDDPCLPFNATNVTKCEDGVQWVWKVIGDCVVTPREQASAYLGLISMLTWMMVGIPQIIKNARNLEGLAGVSFFLLFQWTGGDTTNLIGSILTNQLKFQVYLAVYFVLSDVVLLMQYLMFYVRKRRRQERERREQLSIQGPQLILCFMGLFALSHTVLSLAWTSPDAALSHRATSGRLSRSLLSIEPDSQDVLVFSPEDNMEEISRGVLGQDGNVLSRQVPVDAMAAVHKGKNCSLGTGSANFWHDTTDIIGYVIGVISSIFYLGSRTAQIIKNVQKQSTEGLAVFTFALAVLGNLTYGGQILVRDLSLEFILEHFPWLVGSLGVIGLDVTLLAQFRYYSSRNRNNDEMRKALLTKDYIIKADEVAPVEVPPVEVPQPTDLRFSGDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUA6</accession>
    <name>A0ABM0JUA6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transforming growth factor beta regulator 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101863033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005101654.1">
        <property type="nucleotide sequence ID" value="XM_005101597.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863033"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040092">
        <property type="entry name" value="TBRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715:SF0">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00542">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005101654.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="48896" checksum="2CB9A5775F945B07" modified="2025-10-08" version="1">MAAPSSSTNQTSSAPKISAPSGSNTDTATASGTTAPSSMETKPSPKLLDQLMQKKYSTIPHGIPPSISGGSGSSPGQRVRSAAVNGQEQYANKLKKIRRAIKDTIFVNGAVCDEVLRTEEKLAKAKEERRFLLRKLLQYQSVTDTPTATVKTESQATPARQPKTPAGSLDPMASETSGKPSKGVKRKAAGASPVGAGISPSASLASLSRPGDAKKKAPQSAKEILDSLQVRPKKSKGVNRKVIPPLMLDSLGRPVFPMALGDVTLHSIGEIVPDRLSFHCPDSIYPVGYCITRVYASLHKLDTKCLYTCKISDNNDGPLFEIAAEDSSDIVFKATTPTECHSLLLRAVNKSRGEILPTEGRGLDFFGLSHPVIQNLVQSCPGARKCSRYKWVKFEINKAETNDNVAVGVTDPCVSYDALKMHMIAIGQSRPGQNLAAHVEQSTNLRSLLTKGSGQGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV89</accession>
    <name>A0ABM0JV89_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'(3')-deoxyribonucleotidase, cytosolic type isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101856819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102318.1">
        <property type="nucleotide sequence ID" value="XM_005102261.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856819"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.40">
        <property type="entry name" value="Deoxyribonucleotidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16504">
        <property type="entry name" value="5'(3')-DEOXYRIBONUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16504:SF4">
        <property type="entry name" value="5'(3')-DEOXYRIBONUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01145">
        <property type="entry name" value="C1.2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01126">
        <property type="entry name" value="C1.2:_Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005102318.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24539" checksum="FB2D5456479950E4" modified="2025-10-08" version="1">MAGKNSFRNHSERKLLVLVDMDQVLCDFEMRLLQEFQSRHPNDPFIPLEERRTFYARDQYAKIRADLADNIRDIYNSEGFFRDLPEIPGACDAMKELKEMEGVDVFICSSPLTSYEFCLKEKFQWIEEHLGQEWLDKIILTKDKTVANGHVLIDDRPNIKGAIRKPIWEHVVFTACHNVHSDIRGKRRLDNWTDGSWRDLILDLQMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYB8</accession>
    <name>A0ABM0JYB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fibrinolytic enzyme, isozyme C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005104435.1">
        <property type="nucleotide sequence ID" value="XM_005104378.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850585"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005104435.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29699" checksum="C73BCBA0EF43A43F" modified="2025-10-08" version="1">MSEKRIIKGNPAALYSHPYIASLQYYVRQWPSSGWKHICGGSLINRRWVLTAAHCVDGLVTSDMRIELGALNLYENPNQYEETIRVANYTKHPHYRATGSGIPNDIVLIYLTKDATLNKNIQLARLAPSGSSFAYTQCVLAGWGAIRTGSNPQDAETLKEVKITKIPNDRCDNLWAGQAITDSHICVHEADRHPGQAPSACMGDSGGPMMCGHGHDILAGVASWGEKTCSGTLPSVYTRVSAYLSWIRHRLVIRSHSEGRPYPSNIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYY3</accession>
    <name>A0ABM0JYY3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glucosylceramidase</fullName>
            <ecNumber evidence="3 6">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101858569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="3 6"/>
    <dbReference type="RefSeq" id="XP_005104817.1">
        <property type="nucleotide sequence ID" value="XM_005104760.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858569"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045704615" description="Glucosylceramidase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="8">
        <location>
            <begin position="103"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="9">
        <location>
            <begin position="454"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005104817.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58161" checksum="D7D8953C4185DF0F" modified="2025-10-08" version="1">MAANVYVMLLFISSVLFVCIQSFQATSDVKCSLRSVSFEHKVCVCNSSYCDTTPTVEPVPKGQYIVFTTSRNGLRLDKKVLKAVNVSKSAVFKIDTKTRRQKIIGFGGAFTDAAGINIASLPSDAQKKLISSYFAKDGIEYTVGRVPMASCDFSTHPYSYDDVAGDLTLSKFALAPEDLKYKIPFIQQAKTLSPNPIRMFASPWSAPAWMKTNDNMTGKGSLIGEPGGQYYKAWALYYVKFLQFYQQHNISFWGLTTQNEPIDGLQQNFPFQALGFTPETQRDFVKLDLGPALHTAGFGNVSLMMLDDQRLLILDWTKVVLSDPEASQYLSGVAVHWYSDFLVPSDVLTKTHTNFPDKFIFASEACEGSMPWQKHVELGSWERAASYTKDIITDLNNWVTGWTDWNIALDMTGGPNWVSNFVDSPIIVNAEKKEFYKQPMFYALGHFSKFLRPGSVWVKVESSESIPGIEITAFYRPDNSLAVVIHNLGIDTVELTLTDDGSAFYPVTSPGYSIQTVLWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ55</accession>
    <name>A0ABM0JZ55_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="9">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101851975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 9">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005104964.2">
        <property type="nucleotide sequence ID" value="XM_005104907.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851975"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="64"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005104964.2"/>
        </source>
    </evidence>
    <sequence length="243" mass="27779" checksum="8867E27D48F20D25" modified="2025-10-08" version="1">MADMGTETNVDPDEFNPQDWKAVSLTHVEYPKGDFLGLILAWFSLLPFMLIVSFVTLTLFRRDLHTIAFFAGIVMNEAINLAVKHTVREPRPLRGRQNLYTEYGMPSSHSQFMWFFATYFTLFLLIRLYKNSNIIDDLWKYACGAGGVICAFIVGWSRVYLKYHTVSQVVLGGALGSVMAGLWFALVQLLLTPLFPLIANSPVGELFMLRDSTLIPHVLWFEYTCSRSEARSRQRKMSSRKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZY4</accession>
    <name>A0ABM0JZY4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105493.1">
        <property type="nucleotide sequence ID" value="XM_005105436.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854890"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12264">
        <property type="entry name" value="RRM_AKAP17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056852">
        <property type="entry name" value="AK17A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484:SF4">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484">
        <property type="entry name" value="B-LYMPHOCYTE ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25015">
        <property type="entry name" value="RBD_AKAP-17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005105493.1"/>
        </source>
    </evidence>
    <sequence length="1434" mass="166241" checksum="DDBDAC018B5E1680" modified="2025-10-08" version="1">MANTTVCTDTSEAVDLFEPQNLFLKPIAKVNICVQLPQLKAAGKTISNWEVMEKLKHMVRPEVFLTLKIFKSTMEFIRLEGEIENKSKIHNIILKLDGKTIKLSGFTDILKVRAAEAKVNFPSRHDWDSYFRDAKNMNEMRPGERPDTIHLKDLPTRWFSYRRSDRDGEKELQPCESVVKRVFQSFGDIRCVDIPMLDPYRKEVCANLKKSSIQTFSFGQDLTFECFIQYMDYISFVKAMDSLRGMKLLYKGEDKALTAIVKVDFDKTKHLSEKNIRRRRIEREKLEKLEMERLERARREKEDEERKKEEERRKKEEEERERERRRQEKLQRKEDRRKEREEKRRQKKLEKKQKEEEERMQYKIALEERRLLIAQRKLESLRILSELFERIKAIRVKKYLEQKEKELEEERKQQVEEEKKRVLEEEMKKAEEKKQKKMKLQEQEQELRNKILKNFKAKEEQKQEMQREELRKKIAGTRKLKSAVIMKKAVAKAVKKRKNEPGSTDEESDDDEEEEEDDDSKDMGIKAKDTLKSSKRKSGNTGSPVSKRIFIRREPLKAGSQGTSSALGRQSSGSAVSSAEDFSDDEDEADEREEKGQRPPGSSVMERVLKANRMRAWREPGDPSADSPPREGLAVRGHRGRGRGRGVGPVRGKKVRGGAAAVGEVRSKVSTRSPEQGLARSSSGNRSRSFSRDMSRSGSREGNRSRSRERSGDQGRHSRENHRSRSGDGSSGDHRSRSRSCSRDREDREREMMRHRGPMPPMVPGPGGVMIPLPPHPMMFPPHFPMGFRPPFPGRGGRGPRGMRMRGGPGAMMGGRLPPPPPPPPGFRGGLHVFNKSYLRKYNNFLGMNNQIRDMSGRFAQPLQVELPPQRYKDGDRQDRRNRRRYPEKGRRRRRRRDSRDSSDDKSRSRSRDRSRSRSRSRTRDRSRSRSRDSRSRSRGRDRSRDRSRHRSRDRSRDRSRDRSRDGSRDRSRDRSRGGSRDRSRDRSRDKSRDRSKSRSRTRDKSRSKERSKDRSKSGSQSGNRSPERSEERRRREDRSRDRDKSEDKLESESKSKDASKNRSRSRDNPENRSASDSKGKSRSRDGSEESKRGWSRSDHRSRDGRRSKDRSEERRRERSRSKEKRSQERRRERSRSKEERSQERRSESSRSKEERRRERSKSKEERSRSKEERSQERRRERSRSKEEARRERSRSKEQRLPVQEKKRGKSSGEEDRSQVGGRGKQGADGGERSTSQGSGPSEKTRRDGSTSRGRGQGRDDSSSRRQQENEGGENDGRKNKSQDVVEGTPIGDRKKKSNAKGEGRQDRREDDESGPPKADQNCGDEDSNRGGGNSSSDRKKRKNGNGEGNGSKDVGGGGRSKREEEEKQRGASGKGSGEKKQSEKAAKAKSGSAHKSKSDGDGAERGLGGETVGSWDDMRNDANSEDRKESGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0K1</accession>
    <name>A0ABM0K0K1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-mRNA-processing factor 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101854192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105924.1">
        <property type="nucleotide sequence ID" value="XM_005105867.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854192"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="510"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="542"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005105924.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="65157" checksum="27584C170E86F524" modified="2025-10-08" version="1">MAALLSVQDYGDSDGSDDSGAGSSNELNAHLKPLPAESSSVSAKLALVAAPVVVSNEDTTGLRHIDGKTKELKYNPKFDELFAPHVGPVNPYKTQQAQAVRNSLSGFVEHAHFNHFQFDNQRKTFTSYGFAVDPSVDTGGGQPETIVGSSSAVEENQGRSVFENNPEQDKAKKRKRHKNCDASDVDGYLGPWAKYEDEETVSRPSEEEQKDLDEILAKRSKSGKQVDEKTVEEKTTLHIKDAYDYQGRSFLHPPQDVGVNLKSEEPPEKCFLPKKLIHTWSGHSKGIAAIRWFPKYAHLLLSAGMDCKIKIWEVYRDRRCVRTYVGHKQAVRDVCFNNSGTEFLSCGYDRYCKLWDTETGECKERFTSRKVPYCVKFHPEEDKQHLFVAGTSDKKIVCWDIRSGEIIQEYDRHLGPVNSITFIDQNRRFVSTSDDKSLRVWEWDVPVDFKYIADPSMHSMPAVTLSPNGKWLACQSMDNKICVFNALNRMKFIRKKTFTGHMVAGYACGIDFSPEMSYISCGDADGKVYIWDWRSTKLYSKFKAHDDVCIDVLWHPHETSKMATAGWDGVIKYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K157</accession>
    <name>A0ABM0K157_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101851143</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106331.1">
        <property type="nucleotide sequence ID" value="XM_005106274.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851143"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045901968" evidence="1">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106331.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="12913" checksum="0F49AAFD992DC12C" modified="2025-10-08" version="1">MLFAVLVLILSASIADSTSSALATPSHGVDIETSHNQIHAGLTNQLTINCTFTHEQGSNFSTILSLILSKTDSANDSTYREVASITAFSNDKVDEKNTMDAQVTGHHRVDAYSFIALEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1P3</accession>
    <name>A0ABM0K1P3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integumentary mucin C.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106667.1">
        <property type="nucleotide sequence ID" value="XM_005106610.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847991"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106667.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22631" checksum="C190F10D68A34867" modified="2025-10-08" version="1">MCATSDKFLTDCEMGVTAPLYAKSNFTQTMCEEVHKEYRESEECLQSLKDIVGFCISSSMRPDASQSLCTAMLNTQNCTLEVVKTCGINAKWVISKLLRSYFKPFEQWHGCPSTMQDVKTPSPTTPTTTTTTTTTTTTTTSTTESTTTKKATEEDKSETDSSETDGKASQSKDTGNASTSVTARGPFVLLFSWLASVYVPMKIFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1U2</accession>
    <name>A0ABM0K1U2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAG family molecular chaperone regulator 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106743.1">
        <property type="nucleotide sequence ID" value="XM_005106686.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845643"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037689">
        <property type="entry name" value="BAG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12334">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12334:SF6">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106743.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27187" checksum="AC40DDFA6C922E3C" modified="2025-10-08" version="1">MGDFSSPQPPQSTSFLMASNNCDDPTQDGDKKDNTFLYLSYIDEMEDRVQALRRNASSLAEERDSLLAILSDMKTDCLKETWTEDATQELHSSIDQLRARCQSVQINIRVIRTAEQQSSFTKVDSLVTGLEHQCALGDPEEQGYRKKAESFLNACVSDQVKPGLIDYKFQGMILGCKLEDQKEFRQRLECLVQGRCHMNFLDGMMQQFNIVSSLTSSDCDVISENNQGPNTEVPVESTVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2H2</accession>
    <name>A0ABM0K2H2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101849877</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107194.2">
        <property type="nucleotide sequence ID" value="XM_005107137.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849877"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="231"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005107194.2"/>
        </source>
    </evidence>
    <sequence length="766" mass="82733" checksum="1569A4163D9C750D" modified="2025-10-08" version="1">MANAIKMGYSPSPSTQYRNSRFYRKSCQCRHQASSTGSGKDPTPTVFYRATGSVQCVGLGLADTQSLTSRPGVTLNKGTGGSLENKEEEEIRELAVLGTQCQERTGTGFAEKPSAVSCDQPRFSGDNSSVSLTCETDRVYPQALCQFYWKLLAGGPVGRIDNTDVQYSHTAVRSSSVTYYRSTCNQTVPLSSLQAGDITFTVNMYPEFPGSDTTYGTTNVGSPVSITLSYPTVTITSCPVVVKSADNYKSGYIREGATFTCQCNLANSGNPTGAIVWLNSAGHTVSTRNLLRSDVAKSGESFTCRGSSPIRIGFNPLADETYSPNVAYGPTQVTVSLVDGQGESRTLCPSHTLSIPVVCQTPLVNISPKPRCSILVTKSGLTSYTEDFSADQGQVQSGQYTFSSDVPVTEAGDYVVTCTMYNSVFGDLTDSDSIELSVTDPVISHPVFTVNGKVRDEQIVPGDNVTVTCSDTGVIGEHIDLLCINNRVNINPDDEDKIEFLSVRTADNGTVCVCKWTSTLGCLLQGTKTLTVTISLSESELGGDDGDSEFPVTFVVIAALGVLCAVLAVIIAVLVIRRRRNKPNQDRNQTSPQQRRRTSQPEETRAHAEPVTSGRDVSRMDQSKNAYDEIDVEPVTAPDGQLQTTVTFSRSAQENQGHTTDSSSPYLFPDLVPPSTPRAPSHVQENPYLEIDEERMAAYLFEQPPSHPRTPAANNLYSVPRTGASPLPATSTSGEKDGYTRMDVPSAKEKTRATHQYMNVNTNKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K322</accession>
    <name>A0ABM0K322_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101848068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005107607.1">
        <property type="nucleotide sequence ID" value="XM_005107550.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848068"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="1 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005107607.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33522" checksum="9AC8B708B624EFA9" modified="2025-10-08" version="1">MSAAVRHFTYCRLSRWRKWHSQSLKVPSRSLSSGDHAELDEAHHTEDQETSENQPYDVLYPGHISTSFFQKSLLAFGSGIACLLNPARDDMICALGETTGPPALKYMQRKMLADPVGRQILEDKPLISTDTIDVPYLGSLPEGTFGKEYWHFLDKNGFSPDARRPVNFVDDTELMYVMLRYRQCHDLMHTLLGMPPNMLGEVAVKWFEAIQTGLPMCVTAALFGPVRLGPKHRQKYTNTYLPWAIRSAYNSKFLMNVYFERHWEQDLDELRKELNVEPAPIPLIKTGKNTVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K401</accession>
    <name>A0ABM0K401_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="4">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101853883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005108220.1">
        <property type="nucleotide sequence ID" value="XM_005108163.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853883"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="9">
        <location>
            <begin position="113"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="8">
        <location>
            <begin position="261"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108220.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47529" checksum="4CE9EB0DBCB4F0CA" modified="2025-10-08" version="1">MNFLHRVLLKAPSASCSHKLLLRTSARASSKSSQNDPPPARESQSDSASSSTSSSNIDAFSIMRGKFSPDFAKKAMLKKESLTSILRPKTSKIELTPDSGEEKTKPKRFLVGRDFLSLKHFGKDEIHQFLWTAKDLKTRIKDNGEVLQPLTGKTAALVFEKDDTASRLNAELGLARLGGQAAYFNASDLHLDGKENWKDSARLLAGAADLIIVGAGKQEVLEEVANESTVPVVTGMSDLLQPLQVLAYFVTLQEYFGYLRGLKIAWIGDGNSVLNSLLYGCARLGIDLNTATPVGYEPDTDVMLDAMKISGQTGASFLIGNDPLQAVYRADAIIADSWTKPGADDENIKKRIKDFAGFGVNRKMMKEAGGEWVFLHSLPRRPHEVTDDIYYGQESLVWRAAENRLWITMAVMLHLFQPYSPTTPKPKYVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4Q9</accession>
    <name>A0ABM0K4Q9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101847374</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005108711.1">
        <property type="nucleotide sequence ID" value="XM_005108654.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847374"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015371">
        <property type="entry name" value="Endonuclease-VIII_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF27">
        <property type="entry name" value="ENDONUCLEASE 8-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09292">
        <property type="entry name" value="Neil1-DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005108711.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54944" checksum="5691A78696C7AE65" modified="2025-10-08" version="1">MPEGPELYLSALFINRICENLSFSGKIRRNPVHKSADIVWDEPEYTIRAQSRGKELKLNLFAAPQDVTSNKAGKQLELKSTSIHFTFGMSGKFEFTPANELLKHSHLTFFTKNEPKMALSFVDYRRFGRWFQDSSWSADRGPCIIQEYDVFVKYIADNLHNVAFNKPICEVLLNQKFFNGIGNYLRAEILYRCEIPPFQQAKSVLKLQENGTEIKQEYKDTGVTIKKELEEMSVKQQNTSGQDTQKASKRKGQNGKCDESSDCKYLKVEKVEVEETKGMMNGDAAESFLATHFDSKAQQVLQLCHKVPLEVVELGSKKDSLSEMYSDESDSSYRNWLQCYYQPGMKNLADHNKRTIWFSGPPGPMVPKEQKSRKPKTKKSSSDSNAKKEKTRDDEDTGGAEKKEGRLTRRQLSSSSKLGKKSSKAQKVSAKKKEKSSETARQKAAKKSTVGAQSNSNLTLVENKKQKQSKDGSRITRSSLKGKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K548</accession>
    <name>A0ABM0K548_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hamartin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108980.1">
        <property type="nucleotide sequence ID" value="XM_005108923.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851611"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1276"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="901"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1281"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108980.1"/>
        </source>
    </evidence>
    <sequence length="1316" mass="144434" checksum="A2383FB3C6B84178" modified="2025-10-08" version="1">MASGGGGPLHMENIFQLLESSETVKDIRKIILENLNSTKETWLIHLLVDYYFRTQSTNVQEILAELREAQAKALIDKLHDGIKTSENRLPALQLVLYLVYRELPWCHQLVELPIFSHIIKCLRTEYDVPILMTAMMIVVILLPSVPVGIGPYLTQIFEVFERLSVFCIKKPANTPEVFVLHLQVSLYSLFHRLYGMYPCSFTGFISRVFAHKENLHVYQEVVMPMLERVRLHPKLVMGQKEVEVSANRWKNQETQDIIVACSKLSLDLIEGSWEDSQCPVFHSVQYVDKHRIMNEIFPTRALAEPQTIPAGGGQNEYSGVSQSSLYVPSYDTAAMGESPSVLIGLSTPPSSQRATPATSFLDAGTNTGTVGDTPEMTPRQHTPSQTEDGDKTPLSRSSSRGGIQQPKSGDGKRPVLATPKPVVSVPNTTPTTPGSNILASPLTPGGRGESTPFRSKGSAFASPLQSRSPAMRSLQFNAALEEKEEGPSCPVTVSVTKAEAAKLDSNSQSGSSTPGLERSVDSTGSQTEGKSRTASGDKMANVPMESLPHVISTLNTSDSVNVDQEVEEINEKDDQFHDGGSPSSSSSTTLASQAEVTAESVRQFMKKVNRIRFNSLTSNSSSSDLDTISVTSQVAYQSTRGRPRSCPPFKRLALHQPTPDGCAAGRKSKKFYSAVGSGLVVRGGPGGKFLRQKSAVEGVGAQEILASEDSLDDISSFGGSAKDTPRRSAPHHTEQDAAEEEVMPVLPASVNPVFQYILAPAKLAVCNKCHLQLMVTSSGSSQAANISAAAITDVTTTTTTTTTTTIKGNEVSLFSVVSPPELLDRHLKLGSDIHAKELTKIPLTSKETTNWTHFGGMPPADEVNILRGQILLMQNQLMYERHKRTNHAKRNRRLLRRIAHVATLEEQQKTLGEQVQLKEQEIQQLKVSIKLLQEDHRRLTQSSESDEYEKLVQFRTSLKENKDLKAERIVMKNLMLSQKEDYDKQQKKLENMQHKNLELEKQLEMCRERVANTQKLQDQVFQLQKEVLLMQELHQKCQEKLHQHSAASLHKGEHSCLTASLKADIAELRKENKKKSSLLEAYQTRNIELEEQLKAKDIAMVSVKKNFEAAKSSHEEQLKAVEERCQSMVHINQELESRLMELTCQLDQDKHRRMRQHVAIPQANKDGGGTSSATLTPVNKPIGDQGDSLSMATPHEGDGSRQGTLSDHLSHAGGKKLAVGKEEDSAGTKKGGGTSIVVAKDEVSVIGSTFTEASLGRKPPSRLSSISTRGSAELDLATDSGAASRSSYRVDSDASMQSISTQSLATGDSGCWPKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6A9</accession>
    <name>A0ABM0K6A9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PGAP2-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109734.2">
        <property type="nucleotide sequence ID" value="XM_005109677.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848080"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="44"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="216"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="450"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005109734.2"/>
        </source>
    </evidence>
    <sequence length="726" mass="81750" checksum="5B48813C0FE8ED5D" modified="2025-10-08" version="1">MANPVAPSTSVIDGQNSKQKFKKMPSYNFIEYMRLIVRDGTYGYVFWSIFQGLAPMIWFYPLNELEISGYEAFAVVWLSPVFCLIPGVLPTLQNKWVLTLLRLLTVCSLVSYQANTTFLRLAVLGGGAGISMLVLVATLWHPAKAVRYRTFWGLIVGYHAYLASRVWFTSFVPAWWDQYSNSIVLAAGLVSSLGYILEETPVVESPPTAEKSDGQCSWVTSGLGLGSLLYLTHWCFGEASLLARWTVKGYPNHGPEPLPWGSLVLLALLLGSLFRRRQSTPVFNAIAAAFCFYFLYFYQDPYLAFGAGCCLAYLTMALWPAVVDTATQSHPALTLTLASFVYIIQVLFWVWTVAYNFVPYGEYTREHTDWLIGAVSLGILFTTLMRPSSEESHTALYSTHTDSRVPSFGHYVKVLLLVFLAGQCGMLKRHLDYRPGHPSHKLDKVNAEPNVFSAAIWTFHFGYDNRGWPSMERAATLLNDTGADVITLLESDASKPFLGNNDLAGWLAEKLQMYVDFGPATKDHTWGNLILSKYPIVQSVHHLLPSPHGELAPAVTASINISGTVVDFVVTHMGNDRDTLDRKLQAQFLAEQLRTSRHPAIFLGYVTSSPGSPNYQHLIQKGEVKDIDPTDHDRWCEYIMYKRLIRLGYARISHGGLSDTEVQVGTFRIPEDPQNYMDNEKVTTSPDSQNIDKDIRYNHKFGKHHRGHGYFKNHGFHMNTPKYFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6G7</accession>
    <name>A0ABM0K6G7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101859278</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Radial spoke stalk protein that binds heme under oxidizing conditions. Required for the coordinated beating of multiple cilia maybe by functioning in a redox signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109870.1">
        <property type="nucleotide sequence ID" value="XM_005109813.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859278"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052320">
        <property type="entry name" value="Cytochrome_b5_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281:SF0">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="11">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005109870.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25422" checksum="6AE3232B645D1EF7" modified="2025-10-08" version="1">MVVVARPKYFTPNEVSVHNTTDDLWVSFLGKVYNLTPLCEKYKGDVLLKPIIQSAGKDISHWFNPKTKDIRTHTDPQTNCIIPYCPNGRFVHIAPPYPDSNWANDFGRPWWKDEAYLVGILSQKTRLIKIINTLTSQDQVIEVCSEEVMTEIRERYLKYNAHAASYTWKYDGKNLDMDKTLQENGINDEDEEFYQLSMNDDTYLQPIHLYFNDDLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K702</accession>
    <name>A0ABM0K702_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110217.1">
        <property type="nucleotide sequence ID" value="XM_005110160.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862148"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045274659" evidence="1">
        <location>
            <begin position="41"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110217.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19704" checksum="AF00368A77AD08B5" modified="2025-10-08" version="1">MCSVFGPAPRQGNTMRLSSVSSPLLVLLLALLGLVGRTSGWDSDDWEKLHFDVRDMLAVSTESPPTPQFHWKQRLLPKDDDSSDMSLPPNLLLPLKSILSGDATLETESSTPSDLEEKWNTLSLLGKKMTALTQEILKIGFLLLRDFLGIAAVDSPDMPASKCSGPGCVVEPTVAPTVEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7R0</accession>
    <name>A0ABM0K7R0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Steroid 17-alpha-hydroxylase/17,20 lyase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101856138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110763.1">
        <property type="nucleotide sequence ID" value="XM_005110706.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856138"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005110763.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48887" checksum="43EDB2EFFB8822F2" modified="2025-10-08" version="1">MGKIVFVNDSDLVRRLLCDPENRDITNDRPPTFGGKYFCYNYKNIITANFDTELVKRRKVFHTALKVYGDGANMLETLVLDMKSKLKNYEGNVPLKNELSDLILRVVGLLLKGKLLVDTDLEVITKFLDTANECFQIENDTVLQFFPLARFIPGLKIKRLVDDLYLYRKELIDSIFLKVKEAYLQGEKSGVISELLEQQKKLEEEGQFEILSDEVIITLIMDIVGASYLSTACSISGLFLYLIKDQKAQDRINGEIQKVIGNSTPGFLHRRHMPYTEAAILEILRILTLAPFLVPHFANADLTIDGYTIPKGSTLLLNSWYFHHRDDHWDQPWNFRPERFLDGSGQLVDPEHPQRRKLMVFGTGRRLCPGENFARSRLFLVLVTLLQHFRFLPPSGETLPSSHPKDWTLGTVFSPGNYQCRVELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8A9</accession>
    <name>A0ABM0K8A9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC101855988</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC101855988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111165.1">
        <property type="nucleotide sequence ID" value="XM_005111108.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005111166.1">
        <property type="nucleotide sequence ID" value="XM_005111109.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005111167.1">
        <property type="nucleotide sequence ID" value="XM_005111110.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005111168.1">
        <property type="nucleotide sequence ID" value="XM_005111111.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855988"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF15">
        <property type="entry name" value="SLL1173 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="140"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005111167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005111168.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37318" checksum="A488DEC4B3F07218" modified="2025-10-08" version="1">MIDLRRGRERTVLVLVAVVCVTWLTVRYMYQPKSMPVLQPLQNIKVQRMNAPQSTIRPGGLSNLHPSVNVVKSYPSGELPYNDCVPLPESPRAGVKICVYPSQNDIYVSKDLKEGRLFERHLIRQMADVLQSDPTLQFIDMGANIGIYTMFAAACGKTVLSVEMLPANIHQIQHSLAESGLSNQVTLVNNALFSDHRSLTANFISGNVGATHLNVSKTDFAKYGMREDNSHTVTVKTICIDDLIPLLKSKKVFIKIDIERAEAKALSCAHKFFDEVDVRVIQMEWMAKSKDEIISINQFMLEHGFKASKSGMKYIPENTNVATTGSNNVFFIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8X8</accession>
    <name>A0ABM0K8X8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Vesicle-trafficking protein SEC22b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">SEC22 vesicle-trafficking protein homolog B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC101855761</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus</location>
            <location evidence="16">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111656.2">
        <property type="nucleotide sequence ID" value="XM_005111599.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855761"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="22">
        <location>
            <begin position="80"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="23">
        <location>
            <begin position="210"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_005111656.2"/>
        </source>
    </evidence>
    <sequence length="291" mass="33378" checksum="62A454653DA5E7D8" modified="2025-10-08" version="1">MTRTCGYLREAALPRAKSSQQQSSRHDYRATSGFQQTRSPVERNRFSVGHESSDSTSDFVYGTSDFVDGTSDFVMVLLTMIARVADGLPLAASVQEDEQSGRSMMEYQTQAKQLFRKLSQDPNPPARCSLETGTYLFHYLIERSVCYLVLCDKAFSKRLAFTYLEDLQNEFSSQYGSRLDTVSRPYSFIEFDTYMQKARKSYMDSRARRNLSHINTELQDVQRIMVQNIDDVLTRGEMISVLDTKASNLSTQAQKYKKDAKYLNLRSSYAKIGAVVVVVVLFLLFLRYWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K943</accession>
    <name>A0ABM0K943_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrinogen C domain-containing protein 1-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111820.1">
        <property type="nucleotide sequence ID" value="XM_005111763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855689"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF348">
        <property type="entry name" value="TENASCIN-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005111820.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26251" checksum="6FD7A407C09ABEE0" modified="2025-10-08" version="1">MSVADVALDNDEIDSLPRACIDVAGGQARHVVTMYNGMEVLCDTETESGGWIVFQRRTSRNVSFYHNWASYKYGFGDLTGDFWLGLEKVHKLTANKRHEMRLDFITKNTSYYASYDRFRVLGNKENYTIFVSGYWGNAVDHMSGVSGQAFSANDRDNDLNKNVHCADQYHAGWWYTTSCNLVNPNGRWATHVNKADGLDWSGYSDPITFVEMKIRPVDNHEMCPLYFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K955</accession>
    <name>A0ABM0K955_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Autophagy-related protein 16-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101861631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ATG16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111845.1">
        <property type="nucleotide sequence ID" value="XM_005111788.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861631"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="6">
        <location>
            <begin position="11"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="341"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="510"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="77"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005111845.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="61092" checksum="A56058D987B7EC1C" modified="2025-10-08" version="1">MATTGEWKGNILFQLKRRNHKQSEPFQAIIQTNNRLQQQSSHLHSQNVHLQVEIERLKEENLSGQIRGEPGSGGHNTHALEQKLYKLQEELTELHKKRGENAQQIIDLNALLQEKERELQNKDNQLSDMLANNLSLKQEQKNLQQSMTELEATNQMLTDEHQALQMVFTALEEKHRKLNDDYREILDRWLKYKAQEADDINEQNKQFFKHRQEKLQKELQEAANDKVQIDLPDAEGFTPGVCLSVTIPTRAHNVFDAHSGEVYSVQWNNTGSLFATGGADRKINLWRNIGGSCETKGVLLGSNAGITSVEFSQDDSQIVGASNDFACRVWAIGTQRLQLTLTGHSGKVLSAKFLGDSKVVSGSYDRTLKVWDLNSRSCSKTIFAGSSCNDLVTLHGTSIISGHFDKRVRFWDTRGADTSINEILLEGRLTSLCLAPDRTQLLCCLKEIGLKVIDLRMNQVSHTLTADGFKVGCDWSRAVFSPDAQYAAGGSSDGSVYVWNLNKSRVERVLKEHSHTVVACAWNPSGTSLVSCEKGKKVVLWSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9U9</accession>
    <name>A0ABM0K9U9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101847238</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112383.1">
        <property type="nucleotide sequence ID" value="XM_005112326.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847238"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005112383.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24342" checksum="652E4573A24FF7A8" modified="2025-10-08" version="1">MMAGRTEFFVKMNRLILPELESQSAPVRFRPVFYDPHLVEERQLDVEDESDQSDVETEQGKGKHPLPHFFKDPLAGPSADLTKEDTKQDETDTNLKLGRNMRASSGLIGATRQKDIHELMNTRRQLLQQQKEQIELVSEEENSEQAASILVNNLLLKGFHISAPSDSSLPSPFRLPQKNEVSSEEELQASAERQKLIGAFHRELVRVHAKDTSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAM6</accession>
    <name>A0ABM0KAM6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112975.1">
        <property type="nucleotide sequence ID" value="XM_005112918.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863871"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005112975.1"/>
        </source>
    </evidence>
    <sequence length="1075" mass="117244" checksum="C80ADBC601914B8C" modified="2025-10-08" version="1">MGLVTYRKVTTEYEDNGFANPEKTVVQITFPVNTSLLQPTPAVYQNRDSNPNLNDPKQEHIRRGLHVSKAAEIRTPHPRVQIASHFERGGDDSSTFQNLEDLSPSRKAEKGSNSRNLVSYNNNLPRQHENIMTDTALRSPGILEVSRTENNRRQTSQLPHTNQQQASISREPSKSHGEGGKESSLPTPRQRSRLAISPSPTPPIRAVEEPSPTSGTPYSTSALFSHRYITMNLLSHKSTEPVLTTTTLSPSIVRPGLYNLSKQTNPTPFPASVRNESFSTLGISNQLSRNSSGTRADTSTFMSFLDSAVETLHGATSSTSANLARLEVRLPEVTSYQPRQAHGPLSETTVSNKEFVQSIPSATANKMAHSHVAIEELNRLTTAVTSITATKNNYKSIQNPQPNTNLTTDRTRDRKYSPPTNSLPVRETIHIQQPGIRQQHVNTVPSATNTGHAHLLETRPSDVTHNIRTVSLPGDLTLTLTPPSPSLDQQKLSVVNSVIQNILASTGEQELRYAHNHAQLAQRALEKVAPQLGPSPTSRIAAEFPAQGLNKQTRHGGYELSSVSTHDNTMRGSESPPRTSQSQTLYLNEKTGLSDTTNRNTDISSISRNPSSNPGRTALSGQKSNSRRDPQVHYEVVPPIVPENSGQNYQSSSAASSRQAGNTLGTQFRSQTGLSHTPQTDHWGHSQDSGGFNRDAFPQRPPPNTNVVAPFPQRLPPNSNTLSDPQRHPANLNTASLPQRPHQNTYAVLIPGGQSPNTKMDTFPQRSSPTINTAPFPQSQSSSSNKASAAWQGTSFSSNQEQPASYTASQSVQKAPPPTQGGLGNQNYQNPAPLPRNQPYAIQKPPLAPQNNQNNIPYSGLGQESFQNNRQSNNPSQREPPSSPHFPPPPLPHPQDTPHTTQPPFVDYWDFLSWQQSLSSQQRQNPPINSPDSLPPLTTPPPLCPPPEQMVCAPTRASARLVSFCQQRCDVTSGTCSSALCKCSCSGQSSKHDLHQLAKRTTASAPTFYDPIPGAIIESGDLMISGVDPDLLTTPPPVKVTTPAKMSEESFQKFLQHFARMSGKESQGTAEPDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAP0</accession>
    <name>A0ABM0KAP0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101850460</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005113003.1">
        <property type="nucleotide sequence ID" value="XM_005112946.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005113004.1">
        <property type="nucleotide sequence ID" value="XM_005112947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850460"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005113003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005113004.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="50125" checksum="81EE6B822A4BE0FE" modified="2025-10-08" version="1">MGKDKLHINIVVIGHVDSGKSTTTGHLIYKCGGIDERTIAKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFQTEKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKEGQTREHALLAYTLGVKQLIIGVNKMDSTSPAYSADRFNEIQKEVSSYIKKIGYNPKTVAFVPISGWNGDNMLEESPNMGWYKGWAVERKEGNASGKTLISALDAILPPSRPLDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPANVTTEVKSVEMHHESLPEAVPGDNVGFNVKNVSVKEIRRGNVAGDSKNDPPKGTKTFHAQVIILNHPGEIKNGYSPVLDCHTAHIACKFQEIKEKCDRRSGKKLEDMPKFVKSGDAAMVDLVPSKPMCVEAFQEYPPLGRFAVRDMKQTVAVGVIKSVEKADASTGKVTKAAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAP4</accession>
    <name>A0ABM0KAP4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101851556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005113008.1">
        <property type="nucleotide sequence ID" value="XM_005112951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851556"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005113008.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38576" checksum="8D92DAEF36A4B1E0" modified="2025-10-08" version="1">MTSPAMSRCAPTRHLHNVTFLVICCSAMTSFLLLLHVTQTGSPRHTDLLSDATYDDDTRGLNQHAGATRPRRERTPTSGVMPDISEVTTLHPSLREFLARPVINPHPFTYLLTPERTCEAGHVTFLFSVPSAPSNFQRRRKVRRSSLATFAKNPGNNASLLFFLGSPPGHSKRANNTRAQIYKEARNYQDMVLENFPDIYRNIRLKAVSMLKWTSTYCHTALYVIRTDDDVGVDVMNLVQAIRHVGRGRDNFILGHVVENSKLIRRESSKYFISREEYAEDTWPKFALGGVLGYPVKTVRLLYEASLRVKAVWLEDVYITALCGRAVNATLLSHPLFTFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAR7</accession>
    <name>A0ABM0KAR7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Adenosine receptor A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101863407</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113055.1">
        <property type="nucleotide sequence ID" value="XM_005112998.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863407"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001634">
        <property type="entry name" value="Adenosn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00424">
        <property type="entry name" value="ADENOSINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="22"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="405"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005113055.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="60061" checksum="8370AD75BF99AF33" modified="2025-10-08" version="1">MKTTDIVYISAEVIVGLISIVGNIIVVAAILKTARLHTVTNVFITNLAIADIVVGFLVAPCAALSSLGVDMTFYGCVLMNSLILMFTNVSILMLLGVAFERFFAIKKPFVYQRVLTVRRAVYANILIWVLGFLLGLVPMYGWNAGYYEHGPCFFTNVITMEYMVYFQFFGLVLAPLFLMLCVYMYILRIVRRHQRQTNTLQNMFRGQPGQDGHHKDNFHKDVRAAKLFALVILLFGIFWLPVNIFNCVTLFCSGCNFPIEALLAAIVMSHANSSINPFIYAASNSRIKNAILDLFGFKPSGQTEDSGGLGKGRQSSFSHATFHATQTASTHQQQQQQQQQPPVASSQPPFSPRGGKIFTVSKNLVTAGPTNAGVVVNDHFLPRPDSAPRGDHVTHTTVEHIHDTCATRGTPGQHTHNTHNGHKARDVTPPPPHPLPSHNNEPPAVPPAHTRHVTGHVNAAFTLDETCPPSPGGSSSHNNNNNNNSHPTTAAAATTATRAPVTFPVVPDIISARTRVTARSTWPRRQRTYRGPGTWLDHVTADHVTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAS4</accession>
    <name>A0ABM0KAS4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-related protein Rab-14</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101848263</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005113070.1">
        <property type="nucleotide sequence ID" value="XM_005113013.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848263"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04122">
        <property type="entry name" value="Rab14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030702">
        <property type="entry name" value="Rab14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005113070.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24013" checksum="D106C033CFAD762D" modified="2025-10-08" version="1">MAAGPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVASQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIFLIGNKCDLDAQRDVTYEEAKQFAEENGLMFLECSAKTGENVEDAFLDTAKKIYQNIQDGSLDLNAAESGVQHKPATPRNPITTDQPPNKENCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB90</accession>
    <name>A0ABM0KB90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101860628</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101860628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113433.2">
        <property type="nucleotide sequence ID" value="XM_005113376.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860628"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005113433.2"/>
        </source>
    </evidence>
    <sequence length="434" mass="49112" checksum="1C7C745CDB70A7F1" modified="2025-10-08" version="1">MDFADLCYSEQQKAKQQLKQFPGIEATCDKTTTAFLVSNCPAEASDEERRLCEETGDFFETFKIDSLPVQDLRTQFHFRNEHCWRCWNDFGSFEIWQMKIPMSSTRKADYDGTSNSMLSFMRDNRQEVMFSPQLPNTMPVCLEDHADLTMIASCPSCASSEMTRECVEGIYAPVKDVNDLRFYKNHFCLLCNNLKPEADIDKPICSDYYAVELTQRQAGSFFVFVKATSDQKFEFTQTVNRVGTYVWNKVACSATSGSCETVECSDRSIKENGICNPNVLPFTAKAEVCMLKKEVPFTGSCRPDAITQLPREVQMKVLDTFRNATETTLRKFVDPDFSFTVIRDAGAVVGPKAESLLFYVSGHCTELVDEDLFVSVKNHLASLQLELLTIMGICNETMSICPVFSLRNEIGPTVMDYRKSTCHRVLLGPCTNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZU76</accession>
    <name>A0ABM0ZU76_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101851016</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934553.1">
        <property type="nucleotide sequence ID" value="XM_013079099.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851016"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056483">
        <property type="entry name" value="Hisat_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403">
        <property type="entry name" value="LOC100145250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403:SF6">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24066">
        <property type="entry name" value="Hisat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012934553.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38601" checksum="8A9B008391CB5677" modified="2025-10-08" version="1">MRLLKNFSFRRARLSDYYAVTQKLRIVRNDWDYLPGVYNEFVASPGRMGFVALNGNSEIVGAHFGIIVDNGQTLCKRAARVKENLQGQGIFTRLSEVMDEEVRRHGMIKWEVKTCAWANAERVRNGYIQRANFKELYAMESYDMYLKVSDILPVRETSFSNIRPMTHQDLWNIFNDEGICEKFFPRGRVPSFWVPLRPVEDNLKHLINCRTHIFMSCKSHAKFDPDSKPLGTIKASDISMMSLLFCYTTESGFVYNTDLHGQDFSDLESHLKFHLHRLQNVGHESVRWTIMFDSSHKDVIEERIGHCLKEYGVSLTQKVKSKQDVYFEKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUH9</accession>
    <name>A0ABM0ZUH9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidylinositol-glycan biosynthesis class X protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101854851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934728.1">
        <property type="nucleotide sequence ID" value="XM_013079274.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854851"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044967801" description="Phosphatidylinositol-glycan biosynthesis class X protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012934728.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27457" checksum="9CB731DC0830A0AC" modified="2025-10-08" version="1">MFEIGRYVAIWTFMLLSALGSSSEVYLNRDGVTLSRQLVGSGFHREIKTTVTVSNGTRRALTDGKCRLLLLETLSPGVYADPFQLKSLEPFGGPKVAFSAEVDLEATADQSKPLEINIFIDIYSTDEKTPNEWTIGLPVHGRYHRPSLHKGASSVEVIILNPVLYSSCSFPGSSNPVLLAPCDASNNSKCKWNPILYQRKSPYLKMKIPIGREKDKALVIWITIVFSVTVPAILISKLLCPKVKNKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUN0</accession>
    <name>A0ABM0ZUN0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transmembrane protein 87A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101857527</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the LU7TM family. TMEM87 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934809.1">
        <property type="nucleotide sequence ID" value="XM_013079355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857527"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054101">
        <property type="entry name" value="TMEM87A/B_GOLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21901">
        <property type="entry name" value="TMEM87A-B_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046099082" evidence="11">
        <location>
            <begin position="26"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM87A/B GOLD" evidence="13">
        <location>
            <begin position="27"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="12">
        <location>
            <begin position="311"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012934809.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="72790" checksum="2B2DB006993D1A98" modified="2025-10-08" version="1">MAPMLFITSWACVFLLSCLVGFANARPERGKWINGINKDQLTLWYVKSLYSGSQISVEIQCQSDAEVRLNISWVLRRSPCAQEYIGLNSTIAKSYLQSPQFLTTAYKETEYLNATVGYISCHKSRHLYIHPFNYTKPTVTRLTSKKTSATKTDEASTKTSGTEATAAADVSAESGKDGSAAAQPGKDGSAAAQPGKDGSAPAAGSESKPLQEGGTGANRKRREADSSKVTSSTPKPVSSSPAKAKTGVDYFPDRNENDADRFLKVWKDGYYVLILEFSSADSEKPLPDKFHAEITVRMTKDDNYISAADWPLLIFYGMMGLVYIGYGIFWLFMLACNWRDLLRVQFWVGGVILLGMLEKAVFFAEYENINKEGQPVQGAIILAELVSCVKRGLARMLVIIVCLGFGIIKPRLGQTLHKVLIAGVVYIILASIEGCMRATKERPDQSTEWMFAAVPLAVTDAIICWWIFSALLQTTRTLRLRRNVVKLSLYRHFTNTLIFAILASIAYMIWFLTQHRFKDCITDWKELWVDEAFWHLLFSVILLIIMILWRPTANNQRYAFSPLLDAAEDDIDDDQVLSEAYEGMKMRTTKTQQRNGSPRGFEDTERKMEDDLKWVEENIPSSLADKLLPALDSDEEIMNQKFEVSKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW91</accession>
    <name>A0ABM0ZW91_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="3">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012935837.1">
        <property type="nucleotide sequence ID" value="XM_013080383.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860155"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF108">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012935837.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="48503" checksum="FB14E46D5CC1EE88" modified="2025-10-08" version="1">MSGRLRVVVATVAFGMGLDKADVRAVIHYSLARSFESYVQEIGRAGRDGSTSHCHVFLHPQNQDACELRRHTYSNSVDRVTLKKLLSAVFAPCKCVQLATGEWSTAQTAVGERGESTGPVCGGHERALPMDSTVQWLDIREEGIATLLSYLELCPESWVENLHPVYASCVLKCYGGPRQLQALAKKCPPVGVVIARQKLEGKTFSDCSQIEFMVVDICDLMGWDSGTVKRELKSLQWESGPNGFRKTGVLVEFSDLAFHFRSRGDLSDTEMDGVLDFLNGRAQRQERTELRQLDMLAEALNSVSHKNFWMCCDTADEERSNKLKKKLVDFFDTDGAEDAIGRGGDVEASSSQGARGEQRDEASLAQLRGDIRNFISIYGQEHSLTGRAIARILHGIASPCFPADVWGRVRRFWRAHLHTDFNIVLKEATNLIVAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYF6</accession>
    <name>A0ABM0ZYF6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zwei Ig domain protein zig-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101847487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937103.1">
        <property type="nucleotide sequence ID" value="XM_013081649.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847487"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046882792" evidence="5">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="38"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="184"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012937103.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31893" checksum="5979BC0702FC14FF" modified="2025-10-08" version="1">MVHAGKLAVLTLCLIYLPNVALAFFKKYGLQKRFGEIPGSRRSGQRSKLFFKGEPFEPVTVGAKHGSLVLECHVGGSPSPTVHWLKDGVRIPQGSHHTSHDDSAAYEDHNSFGGKTYLRLGSTKSRLYLDCLTEEDQGQYTCVAESPKVRKTQSTLVTVEKGDAMTLTDLEGCVGKNSHRKGAPARLYMWSTTRLEYQGAKVQLFCRAEGVPEPRITWYDPSGKPITEDEDRYRLAKNGDLILRDISWFENMGRYTCEADNGYGTDSADTFLYPTLREDDMELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZA2</accession>
    <name>A0ABM0ZZA2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serotriflin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937597.1">
        <property type="nucleotide sequence ID" value="XM_013082143.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864297"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045231674" evidence="1">
        <location>
            <begin position="30"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="66"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937597.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38016" checksum="C35908B824B77914" modified="2025-10-08" version="1">MILSHLTSAPKGYLIFSVILTLRVPDAVAAYCHPKFRQSVQIPAGHTHTACLDKSPVARSRVPTEAEKKEIVDLHNQLRARVQPPATNMLKLSWDDELAMLAQKWAEACDKEDGELHHDTYRSIPGRFSVGQNLMMGGKNFKGGINGWYIEHKDYTYGEKTGPAEFARALIGHYTQLAWARTYKIGCGAADCDGRSFFVCNYGPAGNIVPFKGPYETGRRCSKCKTCVDDGLCDCKHSECYGSSTLNTETCACECKKFDFLEAPDCHVNCTGSGKDARQCGRKKNFVEKKCTEGFVQAACPHQCRVCPYSDPSYKDDTAELTSPSMLMTWVLTTLTVAFLCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A086</accession>
    <name>A0ABM1A086_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Craniofacial development protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938185.1">
        <property type="nucleotide sequence ID" value="XM_013082731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011805"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012938185.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14429" checksum="F5D67D88A250E0EE" modified="2025-10-08" version="1">MSPRVTFDDESESDYSIALISYRPSQTGQPPVSKVLIRHGLGEDERRIHGVGFAVHNRILNRISTPHGISERITVMEIKTGKAHFISAYAPTLTTENEKKDQFFEELQDAINNVPKADQLFLMGDFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0K6</accession>
    <name>A0ABM1A0K6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein Rab-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938393.1">
        <property type="nucleotide sequence ID" value="XM_013082939.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011856"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012938393.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27029" checksum="3EB78A1454612369" modified="2025-10-08" version="1">MVVFLETCGTHKPAANRDESSRRDSLGQVLSQSDRGAPKVVNVTVVGEAGVGKTALIKRFRQEKFSGDYEPTIGVDRSQVSYYHPSPIVDTPVKFRFLDTSDVIVNPDLAVTLEDRMTGIYAHLSSFVVIVYDITKHRSFEAAEEWLRLMQGFVQPGARFILVGNKTDQESRREVHKTAGEVFALLNGMHFIETSAKDDKNVWELFLTFGSVPSHVVSGRTRYNLSETLDKGTPTWEDLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1B8</accession>
    <name>A0ABM1A1B8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC106011963</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106011963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938825.1">
        <property type="nucleotide sequence ID" value="XM_013083371.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011963"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012938825.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32699" checksum="E62E3CEBE45787CF" modified="2025-10-08" version="1">MDSVTVTLALLGICSLLYFLYGVLRAPTKFPEGPRGWRSYMAIWRATKEWKFHLLSNDWARRFGDVTGLRLLGGKNMIIINNPALAHQLYVTGPHSRDLVHRPSTFVGKYVFYDEKGAYFTHFDDIARQKYRLLEEVFDVSGGKGMLSEKALDEELGHLCQQLSDSAGKDAPLHQLITVSLKNLIHIVVLGERTKPEMDDDLLFSFDRNLNMLVSAEVRMALDMMPSLRHMPGMFRKLWRATQTSQRRAENLAFYSQIVCYLFVCLFVCLFVCLFVCLYSLGWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A204</accession>
    <name>A0ABM1A204_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monocarboxylate transporter 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939209.1">
        <property type="nucleotide sequence ID" value="XM_013083755.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850962"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF260">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939209.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27661" checksum="3A6B5AD8A9C9F8DB" modified="2025-10-08" version="1">MTERAQSSGQRDSLMGNQDADLSSDHHLLTKQEENSLEITREISEKEKNDKDGDDDDDDDGVPTDSGWSWVITFSTFTGFVLLAGYDFTMYFLFPDLVVRFDSRVSVMTSMFSIQSICMSVASVFAANVLMPRYSVRVITVGAGLTSALTTLLMSQAPNMGTFLALTALKGLCHGVLGVCPVTLLGFYFKRRRSLAQALANVGLCVGSMAFPSVVQALRSQYGVQGSLMILSSLELHYVAVYLLLRPVESYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2E8</accession>
    <name>A0ABM1A2E8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-1-inhibitor 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101856436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939450.1">
        <property type="nucleotide sequence ID" value="XM_013083996.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856436"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF146">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047000741" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1623"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="4">
        <location>
            <begin position="534"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="5">
        <location>
            <begin position="812"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="6">
        <location>
            <begin position="1502"/>
            <end position="1593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939450.1"/>
        </source>
    </evidence>
    <sequence length="1648" mass="189530" checksum="6953EF2A4E82717E" modified="2025-10-08" version="1">MLLKMWLLSLLGAALLLTLAASQNTGQEENCLMDSSSGCSYARAPQYLIIAPNRIRSNQVFHVFVSILKMEYGQDAVYVHVSIIKDNVEFANSALRFERPSSRILQLQMPASSQHGKYQLRVEGRLRESDSGNIWQNTTDIHYSSKRASLFLQMSRPLYRQGQMVHFRVVPILPNMMPKYGSMIIYVDDPTGIPVRRWQGVQTNAGGIVNLNFLLSDQPNYGVWHIRVDAFGHIYRRPFTVEEFWEPRFDVNVSVPAYVMETPTVKIHGVVLANQTSGRPCLGNASISAFFRPREEIWNATRGWEKPWRDGYNRREGVVFERPPYIPVRHVPVKDYYMYFAYEYRFIEYFEGRIDFTWSLDQLSKIAARGGETGKLLDSEIVFFVNVTDWYSGLNRTGWASTIMFNSKIKLEWVGEPIRTFKPQSIMKVQVAVTKYDGTPVRGGGTVTLTDVTTPAGSGISGPQTRVPVNGIAEFEYTLGQNTRSMVITARYSDQRQTYSGNSPVYLDESFVRGDTEPITMYATRYYSPTNSYISIMTSTDHPKVNEYMIFHVKTSYFVPRVYYQIVSQSNIITGDELEMTSKQKTFSIALSRDMVPTARIVVFFIRQPEEIVTDVLNFFVNGTGQNQVRLGINRGKDFSRDTIEFNAEADPGSYVAFSGMLLDLYSRGLSDGITENKLIDELMTYDNSANSSYRHLWRTSDTDYQYKFFHGPDYGIDANTSFISAGLLILTDARVPRLFNDEICRLQNTYPCFTGIGEDCYTDEHRCNKKVDGCPTDGADEWGCVYEEDRTVHKSPLDRVSRVMRFYDNSSWAWQEIFVKPDGRVDFRVDVPKYPLSWVINGLSISRTLGLGIMQNPVRYDAARYMYIQVEHPKHIIRGEQIGVRVTVFNYWYDDDYLEVLITMHQGPDSEFVIVGDMGYVTSYTPTTHKKDQQTIVFLEPGESKDIYMPIKPDINLVDGIMTFRVSATCFMEKDEYVGKMSVKPDGVVNYYHTPYLVDLIRYASIQMPQFDVVVPEQFRKPEVRYNLYVPQSPVATTSLFGDVVTPGFFQDYLNAENVLYRPYGGGEMITFNFAYNLLTLKFMKASQQLSNDQLKRSLAEMNVAFQRILGYMNHTEGSFKMFRDDSRPSLWLTAFVVKTLYNANYGEWERDLFIPRELINKILIYICSRQNETGAFDPEENDVTYDRKMASASYIKNDKLRSHPIPLTSYILIALFETEVSEDAAACVDSARRRAVSYLSSNFNDIKEVFHKAIATYALSLSQNRQPFFDLWKLKRNDSDFVYFADHTVYENPSDFLNNVRYLLPRQELMNDAYAVQSTAYALMAHISTNQPEKYEREMMMSWLNTMRNSIGGFTSTQDTILAMEALFMFTQVDAHRNVFDVVTTVEATSSPSWSKTMTLKKLDYVKLFKANLPSNKVFGFTVPVSQGTGRSVFQLTTTFNVEYPFLLKLPQRVDNDPFKDPIKFFDLIVEEQYFSGRNDSIMEMTNCVSWLFTEKSLTSGLAVLEVDIPTGYIVMNDTLRDYVQSGLVPNLRRAEFYGRKVVFYFDYLDESKTCVYFRADRWYPVANATIQHRVRVYDYYEPGMHNTTMYTTRNLFLMNICFVCGSYQCPYCPYFNAANIAQAGASIALFLLSVFIVQRLLLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2R0</accession>
    <name>A0ABM1A2R0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tropomodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106012162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012939656.1">
        <property type="nucleotide sequence ID" value="XM_013084202.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012162"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF6">
        <property type="entry name" value="TROPOMODULIN, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939656.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11207" checksum="92741EBBF54C3EE3" modified="2025-10-08" version="1">MTRFVSSSEQMEDVPEVDLDNLDDLLNALSTEELEELNGDFDPDNSLLPPSQRCKDQTSKMPSGPFSRQKLLSFLEEKAKHEKDWENTVPYSKETKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4Q2</accession>
    <name>A0ABM1A4Q2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-1,4-galactosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940795.2">
        <property type="nucleotide sequence ID" value="XM_013085341.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012414"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="2">
        <location>
            <begin position="123"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940795.2"/>
        </source>
    </evidence>
    <sequence length="271" mass="29643" checksum="18488517A2877536" modified="2025-10-08" version="1">MDRCSKFKVFNLLIVFCVVNFFIYRIYSSQDTSSSPTPSATRAVAASLHGNNTHSSNNGNQATGNAIGASSSTITTLSVGQHTSSQILATVSNVTGGSTNVTGKAPNSTSVGPGASSGQLPLCPLVPPNLNGPLATYSDAPEFAEIAKQNAGLRPGGRYSPPDCTSRHRVAIVIPYRNREHHLKVFLHNLHPMLRRQQLDYGIYVVDQALPGRFNRAMLMNIGYTEAMKRYNYQCAVFHDVDLIPENDRNIYSCPEQPRHLSAAIDKFKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5Q5</accession>
    <name>A0ABM1A5Q5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mucin-19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101846672</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941338.2">
        <property type="nucleotide sequence ID" value="XM_013085884.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846672"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06929">
        <property type="entry name" value="NR_LBD_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="579"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="1426"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="696"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="841"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="891"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1125"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1164"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1181"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1191"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1220"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1248"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1313"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1333"/>
            <end position="1360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012941338.2"/>
        </source>
    </evidence>
    <sequence length="1648" mass="171812" checksum="2F4E6C491CEA9CEB" modified="2025-10-08" version="1">MTGKTATGQGGRLSQKWVICTEMEESRSPTGGTQTPPGSNEWLREAGERAPRAAGDDQNMERAASRPPDSGGQARNNGSGWVTGSAGRHSPLDASSSSPGAAGRRGSTAGLEPPVAHSRAGRTSSSGSGDGVVVPAHSSSGRDRRQSSLASEEAAPSSSSSPTPYNTKPLHPSTPSSSSSSPSVSSPFVPISAAAAASSSSSSSPSPSLSSSSAAPPPPPSSSSPLHGPPQSSPLHFRDRRGSRLSSGSTSSIQEHRQDQAELHVAGSSKGSPGSSATPRRVSGEQLSALSPKEKSASATLSAFNSLHRAELQRQQQKQQQHQQLHTQLHSPSEVHAVSSKHASADVPLTSSASSSGTNESPTPPFHEAPPPQLRARLLDPPPPPVPRDSGGGASGLARIRDAALLRHLETGRSPGSIALGVEGQGRSIAVRAGSPIEPGRAGDSGLDQRLSWKLLNEPSEEGDAHAAVDKRIIPTHLQANSPRPLASSAGVIVTEAPVSRSHLERGGLPSAEYNTYTALEQAQWKSELSYSDVEEAGGRRESLDTPGDAVSNLPSTLAANTGVPSPGAPQQKLKNQSTLKCLVCGDKSSGVHYGVLACEGCKGFFRRALQNVGDPARKKCFYTKNCDINMQTRNRCQYCRLQKCLGLGMSRAAAKLGRRSRKMRDIIRHIEDTQTEQALHGLLSLNADNNAVVSEAKPGAHSPEEPPPSQQAPPPPPHASQLSPAPAVTSDPNPQISMAALSVLLKQRSAAGQLIGQPMVADHAHPHPAHHPAAALALAVKSELDLRTPSSAAAAAAAAAADAEMKSRIMSLMQQAAAERAIGGGAGGVAPEEEQPLMLKVQRSSPSSQPLGSPGIRYSTSASSAPAPAGLVMQHHRPSPGQITPAHSPPATSSGATGTRPLTLQPAHTSHAAPPLPGDLPSAIMAHLAAARGGQPLVYALPGSAGQVFIKTEDGRIEALGPVEALTQNPSAIIPSTLLPSGITASSSSSTTAPLCSPSSSSFLIPSSSSSSSSPSVVITAATAASLSSTYQPPSSTAGHNLVVGEVTGSPAYSDDQLAPPGLATAGNFPSVIVQHNSSLDLRKKVSAVEQFIRSPIKKRPYFPNEGPDDLSLSASTNHPSGDAAVETESATAAPSSSSSSSSAQNVAKRGSSEPKPKRRRTGNSSSATATSSRAEVAAPSTTTEQAAATSTTSNNNNSTNNGRRSSSGSNVGVYPADSLSSRDLSPPITTSHSHSLAQALHRKDTVTAAAVASSASGPSPHTSTASTLSSPPPRSPGPVSSSTLPGSRSGGGTTDPNSHHAFPHHSLNPPPHHHSHHHHHHHQQQQHHSHPSASPTITSTAASTTTNPHNNNNNNNNLPPAPQGLARTDGLIGLARPLGKEEIKLTVPYMVSRLNDSYNTTFTFLKTKLQEMRVKLVEYRSSMTMDSVIGKIISQHLKSGSQGTSTGEMCWHHFQMRLNRTIEDVVCFAKKIPGFAELDQDDQISLIKGGCFEVACVVCAPFIDADTNSIFLLGNSSIVLRDEMKCGFPLGEHFVELLFNLSNRLNAFSLRNSEKALFSALVLISPDRPGLKNREKVSKLQELLIQALQSEISASHSDEGGLFPRLLMSISSLRELGVEHRRMLESLKGQMSFPHDLYAETFDLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6Q7</accession>
    <name>A0ABM1A6Q7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radial spoke head 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941902.1">
        <property type="nucleotide sequence ID" value="XM_013086448.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012709"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941902.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38084" checksum="F89AE2E3BED23645" modified="2025-10-08" version="1">MSDIGSEEMEEEQGPYLGEYEGGRNERDERHGQGKATLPNGDTYEGLYENGKRHGNGVYRFKNGARYMGEYMKNKKHGQGLFIYPDGSKYEGSWVEDQRCGFGKYYYINGDSYEGEWQNHVRHGRGTYFYATTGSKYSGMWNSGKWEGHGELIHANHKYAGLFKENRPEGRGKYVFDIGCEQHGMYVPIEQDKEEKGEEEEPSANVVPKWNAGVVTALHVKTPEEEEEERMMEEAEKVKAQLEAEALAKEEAARKEQEEKEAAEAAAAAAAAEAAAQAEAAAAEAAAAAAAAEAAANEEQTAQEGEEGTTEGGAGEEGGGEEGGEGAGGEGETQEAAAEETEEQTPGEGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8M4</accession>
    <name>A0ABM1A8M4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942933.1">
        <property type="nucleotide sequence ID" value="XM_013087479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012978"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="308"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942933.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="58485" checksum="1AB38CDF3D8A0FB6" modified="2025-10-08" version="1">MSVQTLQRKKFSPSPKVYNPPAKHKPKYGSSSNIQPKKLCTNCGGSPHPFLQCLARNQTCNYCKKLHHFKKVCRKLRYNKTHEITMGDDSTEEEEEEEEEQYGSSCAFETIKLNKCDSEAFATVKVVLPEWGKATLKAKIDTGSQGNALPLRLYRKMFPSKVDKEGTPTDLTLSEVKLTGYGEHLLRQLGTCSIECSYKDNTECTIFYVTEDKGSAIFGLPTLQALGMISLNYCIEKKCKSRTEHIRNKEDLISKYPETFKGMGKFEGRYHIHTSKDVPPVIHPQRKVPIQIKAKIKEELKEKRENRIIEKIQEGQPTQWVNSLVYRTKPNGSLRLCLDPKDLNKAILREHYTTPTLEEILPSLSLSDAQYFSILDAKCGYWNVEFDEESSYLTTFNSPEGRFRFLRMPFGLRMSQDIFQKKMDQTFEGCQGVIGITDDIVVFGKTEQEHDQNLQEMIRRCVETGLKLNPEKCCIKQNQIKFYGVIVTQDGLKPDSLKSRSHKKHEGSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8T2</accession>
    <name>A0ABM1A8T2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106013005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943026.1">
        <property type="nucleotide sequence ID" value="XM_013087572.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013005"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012943026.1"/>
        </source>
    </evidence>
    <sequence length="679" mass="76595" checksum="469AD1B38A5BB557" modified="2025-10-08" version="1">MSLHRGATTQGRKKVQVSFVIRDEVERCHRSGVNALQFDPYLQRLYSAGRDSIIRIWNTRANKDPYILSMEHHTDWVNDIVLCCGGRTLISASSDTTVKVWNAYKGFCMSTLRTHKDYVKALAYSKDKEQVASAGLDRQIFLWDVNTLTALTATNNTITTSSLTGSKDSIYSLAMNQAGSVIVSGSTEKVLRVWDTRMCQKLMKLKGHADNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCVATFRVHDEGVWALQANEAFSVVFSGGRDRRVWATDIRVPDSSELICEEKNPILKLELVEGPQPNIWVSTTDSTIKNWPVRVPSGRSSGDYDNDRWRAAPAFSQPYMTIRGDLSIRQYHVLNDKRHILTKDTDNNVVLWDVLTARKVEEYGKADFEEIVKTHFKMVYVPNWFSVDLKTGLLTIHLDESDCFAAWMSTRDLGLELLPDAPETKTNIGTTLLQALLDQWPRCRPDDGQDPDQEKPPVPSHFTVPGHTPVIFSEVGGRTLFRLLARDAGGETEQMLLKETVPSWVLEVIVFKELPKFNKLPFFLQPHPSTGIKPVKKDRLSASDMINVRKVMEHVYEKVLGQGSDAGSQAANSNSHEKEAEKEEEPVVAAEERVELLCNDQVLDPNMDLRTVRHFIWKQTGDLTLHYRPLSKKDYPSFSKYSAMTSGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAD0</accession>
    <name>A0ABM1AAD0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101864096</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943905.1">
        <property type="nucleotide sequence ID" value="XM_013088451.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864096"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943905.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="24633" checksum="CF9A5B7B8D4D395E" modified="2025-10-08" version="1">MQLPCPGKHSTFGVLLLTTLSFYIYASLNGWTNVVFSRNNRLGFSKNVTGVYLQGSAPTRKGNLTNGHQASSSPTSSPLGRSTPTPESSPTPSLPQDVASSFHRVPGENIWVYSVFYEPFKAELGGPGVRGIGLAPVKNEASVYCHVTFVDGSRTIVRSNIVRSRDSHGLRFSAVHLECRVPANTRPKHVAFARAQNGTVGEQFPVLYPGTERVREFTVCYATLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABA2</accession>
    <name>A0ABM1ABA2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101849653</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101849653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944405.1">
        <property type="nucleotide sequence ID" value="XM_013088951.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849653"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="116"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="242"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="995"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="715"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="759"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="914"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012944405.1"/>
        </source>
    </evidence>
    <sequence length="1083" mass="119333" checksum="92F2B1C085C42CDE" modified="2025-10-08" version="1">MSSSKEYVQHFNQLTLQLLSDKERGELHKGLRNYQRTSDLPRLARTVRRLLDTPEKQKLLAYIRAPMSSLEKCHFDRLFGESGPNSVVMSTISSSRPGFLGPITTPPGSTSALERPVTIHGSRGGSMGFSIRGGSEFGLGIYVSMVKPGSPADIADLKVGDHILLANGVDFNCVANSGAVKVLSSSALLNLVVVRTGKVPEWKVARERVLWYDVASCRVVATPPASETSSTSSAPHVLVERKVVINVSQDSDFIGLNIRGGREYGVGIYVSRVDAGGLASKVGLSAGDQIINSNGVDFTSINHTDAVDELRSSTHLIITIRSLGKYPVYKELCAEYTWSDGTSHTTRQLDAIGGGPPSTFSGGSIARRHTQRTRARESSIDLTPFAHTSHNNNNNGNTNQGYVSADDDNIEEIEELDDGLEVQRTAICYPGDKDIMYRRSYEDSWKELDNITDADDHHTETQMANSWSVDNKDSLGHFRHGSDHSEHAVDYTTFLQQSALREQQRQEIQQQQQQQHQQQQQQHQQQQQQHQQQQHQQQQLRSSIISHGYIESVNNNEPVIETFIEDGEDIPVIETVIEEAVTDFSASSPVFTTTSSAGRSPTPSRSSSQSRENGTSEHVYSEVAVTSVQRTRTNSHSGESSPTAAIQPIYATVNKKRGSTGSVRSVGSGKTRRAPEAPSGAKVVVSNGVTENNLDEISTELRRLQTRQSTLGFREISRVAGSDTSSSSQASSEKGDDSFDKGSKSGTWTSLKNKLKGSLRIKGSNKNRSSIPSADAYARSNSNSSNNSTPSGSLRQKGVFERSFGSQLLNAHSSDRYNLMGVLEDHARRTLKDDECTAVLRHVHNYHENKDLNRLVELLLIILDKSDKRLLLVDVRGVIAPSHVEKFDNLVAHCNLQGYDNAFKRISAQEQFKVRTAEKPERSTKPQPMRARNGELPVGTKGNNHGFYEVNPEEPSFQTFSAEDFKRRPSHLEVVILEKQGNTRGIPKNLDGCELVYISKHKNYLGLQIKGGRNNTEDQAIRIHTVVKGGAASDDRALQPGKEITHVDGKSLLGLSCDEAESILQLSFSIKTPVNMELRLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABV9</accession>
    <name>A0ABM1ABV9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944739.1">
        <property type="nucleotide sequence ID" value="XM_013089285.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852805"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="32"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="153"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012944739.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34022" checksum="FF79FFC55F93D2B8" modified="2025-10-08" version="1">MDKKVLLVIVAVIAILVLAISLVASSLEKLSSKEVGLQYDTIQKDLEDKVYTEGLHLGPVGFEFIVFPNIYTTMKFTGLECLNSDGVRIELDVTYQYRVQMQHLKEVVLTFKDFDDYETVLRSVGTASLHESCSYFNTTQFQANRGEFQDKLAEILTERYSVLKSDVEDLQVNNIKRPSEYESAIRSKERAKENIAVAKEERPRLVTEANTTLREAVSEAVIITDKAESDARIRKNLARAEAEAIIELYNKEAEAYEAIMGSGGLQFSPEGFISYMGVRVIADAKNPVYIGMKSPAKASYIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABX3</accession>
    <name>A0ABM1ABX3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101859981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101859981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944762.1">
        <property type="nucleotide sequence ID" value="XM_013089308.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859981"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF9">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012944762.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23549" checksum="FE67F178C00DA864" modified="2025-10-08" version="1">MEHENNRAAEKEDEMMELADQRRTESEALNELTKQSQAKSRWVGWRQKFKDKEYRRKLLRTLWLTMALFSWGISDGQIGPTVLDLQIITSTGVKEGAAFIMARRFGYMAGALMRAWISRKLAGFSLGSAFLIGEASYGLLPNVTAALQLGCNSELMGQWGEQGRSLMQLMHFGYAVAVEDTFTAYLMTFLVKEYREVTKAFAAYVTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADB8</accession>
    <name>A0ABM1ADB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anthocyanidin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945514.1">
        <property type="nucleotide sequence ID" value="XM_013090060.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846177"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945514.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39046" checksum="455DE27A44A2EDD8" modified="2025-10-08" version="1">MGDELVLVTGASGYLGTQVVKTLQEAGYRVRGTVRSVKNEAKVKPLYELCPGAKHKLELVEADLMKPDSWTGAVSGCTYVHHVASPFPLTNPRSEDELVKPAVEGTLSVLRACVAAGTVKRVVLTSSLIAIAERGGNTTPFDESTWADPNAPNTSFYGKSKIHAERAAWDFVKDLQENEKFELAVVNPVLIAGPQLQGTPGSSTEVISRLLTRGMPAIPRFNFSIIDVRDCALAHLKCMTVPEAAGNRHILSSGSMWYNEIAEVLDKEFRSQGYNVPTTVLPGFLVSVVGFFDKAVKIAKDFASKETLLDTGRMRNVLGIKPIPIEQTLIDMGYSLIENGFVPKTDKYRGPQQSNPPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADL7</accession>
    <name>A0ABM1ADL7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101847923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945656.1">
        <property type="nucleotide sequence ID" value="XM_013090202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847923"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012945656.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58609" checksum="6C0AEB7564A3F89D" modified="2025-10-08" version="1">MGAEDETLERGNWGGKLDFLLSAVGYAVGLGNVWRFPYLAYRNGGASFLFPYIIMLFIAGLPLFFIELAIGQFASEGPITVWKVAPLFTGELFKKDCVMNKTIAETYNDYDMNLGFSDQYNKWMDSFWNAYPSSTGQFSNLTWQQIQTFWGFQACEYEYNTPSQEFFEFYVLRQQNSEDIGDLGDISLKLILTLFLAWLLIFGCLMKGIKTSGKVVYFTATFPYVILIVLLIRGVTLEGYEDGIDFYVIPEWDKLTDAKIWGDAATQIFYSLGIGFGGLLTMSSYNKFHNNCPGLAFIAYPDGISRLPASSLWAFLFFFMILTLGMDSQGGIRVLTLMNDYSGSYNLMVVALFEIICLCYVYGLNNFRSDIEMMLGFKPMYYWIVTWMFLTPVAIIFIIVVSAIQYETSGYGDETFAPWAEGIGWLMVAVPILAILIVGVIQFCRYGYPACIQPTSTWGPSQPEDRTGRYAAINAAFEDDNGTALPYVVDSKNGPPPTLNNDNKGYEYDNSAAPYVTQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE31</accession>
    <name>A0ABM1AE31_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852747</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945930.1">
        <property type="nucleotide sequence ID" value="XM_013090476.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852747"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945930.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22431" checksum="BB66EE503EB06A47" modified="2025-10-08" version="1">MSQRYTPNTRGSASTLSRESDSNPLRHPGRFTSCQAPLVTADDRRKPQLLTSVLHEEKLKETTHRLTLPTECSSARHHARRQVVESKDVNRYLWQKLWPFPKQISTNLYTKTGSLKHVGTAGPPSIPAAYQTGLSANTFCSGGPASKPVLQEVYHRPSHRSAGWRTFQNQWQAHHTFDATQVVTKKPGGLKHYSIHSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AED5</accession>
    <name>A0ABM1AED5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC101863480</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cell membrane</location>
            <topology evidence="1 17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946074.1">
        <property type="nucleotide sequence ID" value="XM_013090620.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863480"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040622">
        <property type="entry name" value="EGF_integrin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012896">
        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036349">
        <property type="entry name" value="Integrin_bsu_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18372">
        <property type="entry name" value="I-EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002512">
        <property type="entry name" value="Integrin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01242">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69687">
        <property type="entry name" value="Integrin beta tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17 24" id="KW-0401">Integrin</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045979437" description="Integrin beta" evidence="19">
        <location>
            <begin position="20"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="20">
        <location>
            <begin position="26"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit tail" evidence="22">
        <location>
            <begin position="629"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit cytoplasmic" evidence="21">
        <location>
            <begin position="732"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM01242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_012946074.1"/>
        </source>
    </evidence>
    <sequence length="785" mass="86636" checksum="88D0EF94F952E35F" modified="2025-10-08" version="1">MKEILLFVALLFVFERASSAICGGTNCVECVSSGYNCAWCIQKNFTAPRCQSRRLLEAAGCDEGLIEDPQVTLSLLENNPVQDSTTTDQAAVQVQPQEVELKTRPGLEQTVPMTFRAANNYPVDLYFLFDISLSMKVQIENLAKLASDIGQAIGEISSNYRMGYGVFQDKRAMPFTDTSPIRLLNPCEGSNARTCAPPFEFKHILNMTKDLELFKRTVRATNITGNLDHPEGSGDAIVQAVTCKREIGWREIGRKLLIFASNDRFHLAGDGRLGGIVMPNDGRCHLDAHGEYTEELVQDYPSVGQLADIALKNEVHIIFAVTDDQTDAYRLLSERIPESIVELLEQPDGPSNRNIRDIVERKYRDMVSEVKIVSDKVEGVEINVRAKSSICEKQGTNVCKGLQIGTEIKFDVDVKVTECPATEDDRFKTVVLYPASLKSDQVLLEIEILCDCSCESKQDTWEENSEICTGGNGTLKCGQCDCNPGRFGQLCECDASDIGATGSEGCIEPGSNSTEACSGNGVCECKQCICEQGFSGPYCECDDTDCDVFRREICGGPSRGRCQCGGCICESDYEGVVCECPTSNQTCIDDKGVLCSDKGECVCGQCRKCQKGYIGSFCETCILCGDDVCDIMKYRECAACELEGDGADRKCADDCPQRKVVKTLNSEEVNFCSVKQSDGCFLSYQITLSGSEVVILVQKTRTCSEPVDIVPIVGWVVGGVLLVGILSLIFWKVLTSMFDHLEYSRFQEDLQKCRWAQQDNPFYRGATTTYQNPMLDRSEPRDHPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AER9</accession>
    <name>A0ABM1AER9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-arrestin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106013938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946289.1">
        <property type="nucleotide sequence ID" value="XM_013090835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013938"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012946289.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20453" checksum="3AF14ACC32C898D2" modified="2025-10-08" version="1">MAGMSGQNGPMDSSADDAQKKQGTRVFKKSSPNGKITTYLGKRDFIDHLSHIDPIDGVILVDPEYLKDRKVFAHILAAFRYGREDLDVLGLTFRKDLYLSSMQVYPPLKDSKEAKPLTRLQERLIKKLGPNAYPFFFELPPNSPASVTLQPAPGDTGKPCGVDYELKTFVADNIDEKPHKRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AES0</accession>
    <name>A0ABM1AES0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106013939</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106013939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946290.1">
        <property type="nucleotide sequence ID" value="XM_013090836.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013939"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038949">
        <property type="entry name" value="TEKTL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35081">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35081:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012946290.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35301" checksum="4A236D210B8DD117" modified="2025-10-08" version="1">MATIVKAPPATIGPECWRNRTLRGLKLGQTVVENSDRNCDIGRSTDTLPHIRDVLATLSNDEIRKYMREVRVVVAKLRESLLETNEEIKALTRGKEALERSLEHTRKDIQLNKDSKQVRVTRPPTEKEKDGADDLLEAEYAHLLNCKKTLELQLRSVQQHLQCLESIRKRTFASLQERSRVLDLLCHALSSVLRPEKDVLSLKPNRSQVEGRVSMVDPGRMGAGRADPLGPYTPEVDTLLGDATDARNQSAYLRRELRAVIDRVDKLKQAAHKSVNEGLTQKVAETVTLKVKVVEVCGSEVLEVCGSKVGGGCGSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEZ5</accession>
    <name>A0ABM1AEZ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946402.1">
        <property type="nucleotide sequence ID" value="XM_013090948.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852145"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946402.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="55005" checksum="B5718F976DF4D0B9" modified="2025-10-08" version="1">MLYPTASEDPGEELLTWEPQDDLEFDDDFQLTKRTKSIITDLVASKPTKGKLKFTKHGVPCDDSDSDLEDFHHILDQSDLQLKLADQSLKKKRKDPMGTGLHPDPAKYKEIIDTCVTNIQCLQSICQHLSTEDVMQEDVTRVQDLMTQWQKLEALASDRFDQSSQLSKVRDQLSIMSRCVKGAEDCLALDRFGSVDELKETIRQLKQKRQTLDLQQEQISELEKHLKGLSLTYPSLYVDKYAQELAALGKLTAVTSHKLKESVGQLENNWSVWLEYIEGQRELDAFLASDRERVYSLLCQRERGLRLTKKDVLKELETLQSNVSVCESKLSVLQEMRARLLRTSDDSAQRVFMASLGDLRNQLHVMSERCREVYRDMDDEDELPASHQSDLGDLAISAATLHEAFRNPHDVGSSLSKRLAASPLEEASTGMSRSSASWLRSLPVQVVTLVLVAGLVCALDPDILERLANFSLTVTPELHYVDGPPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG04</accession>
    <name>A0ABM1AG04_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450 7A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101851104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946916.1">
        <property type="nucleotide sequence ID" value="XM_013091462.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851104"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF4">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012946916.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="59266" checksum="6BA365A6B8586A83" modified="2025-10-08" version="1">MLLPEIINVLIPASICTPRKQLDVGSLRVSLLATELLIREDAYHLLPIETAALQLGLTEDLRPGEPTIVPGHFFWGNAKQFGSNALAFLQDAKEKYGDVVTIRMLDKYWTIMLDVSSYEAFNNERNFSFSPVKAMINTNVFSYTLQQHEKVIAKISNHLNGVALYSAFEEFVKSLTRVVSETEEHVKTTNTLDGQTPQLLDKDSVMTMKKTDEKLTGVKGFKDVLQDDWCEEGLQKVVAKVFFNSQFYSFIGRPEPGSKSNVNPDYFFDVYNEFHDYFYHLFAGLPIQIFPTAGKARDKLHASLDIPEILRRPDSSEYIKKATEFILANGQTESDCRNHILSLFHVMFNNLGAGFWCLYLLMHDKAARKSVLKELEDAVETKRVEGHDGGSVAEFTVEDINKLSYLGELYTYHLRMSTFKYDRFMNNPDFYKDGKKLRQSTFGFGTLCPAQKMSMLQLKWFTMVMVNNFKMELVDGDTAELDVTKYGNEVIPPTNDVRIRMKPKEGAVRLENINARVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPM7</accession>
    <name>A0ABM1VPM7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MOXD1 homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824369.1">
        <property type="nucleotide sequence ID" value="XM_035968476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860240"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824369.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34932" checksum="876ABD3A52F8D040" modified="2025-10-08" version="1">MTDYRDSSGLRLYYRPALPQVQDLRFTISHLSSGESRVEQVGTCPGTCTFGLISKPAYVISVYNHMHYLGRAMKVELFRNGKMISELSNDEFYSYDSPVEYDHKPPVQILPGDEIKTTCVFNSLSSDRWVYYGDGTNDEMCYGFLTIYPRDAVPFTTSCVSFGPASTCEMFGPQKQPINGCDWNAFTDESHPETARLWQDLEKNCNLDGFCRPECRKITDELKKHPCMQGEVADLVNFRLARNHEGSKFLGRVHSCPTMDQNPGDVNCSSHCSDVCPGNVRDNAPGSAAMFWLVTLSFVLVQTINVFSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRH1</accession>
    <name>A0ABM1VRH1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide-binding protein G(O) subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825013.1">
        <property type="nucleotide sequence ID" value="XM_035969120.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857635"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF231">
        <property type="entry name" value="GUANINE NUCLEOTIDE BINDING PROTEIN (G PROTEIN) ALPHA V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035825013.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41715" checksum="7BE6DD87635E5A94" modified="2025-10-08" version="1">MGLCFSLDQEEQKAKSRSDAIDHRLRKWAKDDENVINILLLGAAEGGKSTLVKQMKIIHHDGFSYEELMSFRPAVLENLLSSMKFVLSGMGLLRINLEKSNNKAYAHTILSCQCSYDEEFLMLSHIYEALRHLWRDRGVRSAVARGYEYELNDSAIYYFENMERICSIKYTPTPTDVLRARVRTTGVIETWFKVEDVMIKMYDVGGQRSERRKWIQCFDNVKCVLFVVAISAYDMCLIEDPSVNRLEESLKLFSQICNNRFFINSTMILFLNKLDLFQDKVRYSKRHLRYFFPDFPGPDKDVDAGARYIQHLFMMQVTSPSKVVYPHFTTATDTTNIQVVFQVLMDSILRDNLKSTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTC7</accession>
    <name>A0ABM1VTC7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine hydroxymethyltransferase</fullName>
            <ecNumber evidence="4">2.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine hydroxymethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Serine methylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101851498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035825669.1">
        <property type="nucleotide sequence ID" value="XM_035969776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851498"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="8">
        <location>
            <begin position="40"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="8">
        <location>
            <begin position="234"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035825669.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45210" checksum="FD8D3F01904E26ED" modified="2025-10-08" version="1">MLTRNTMQCVKRSNKCLIQRMKSLPRVTWARSVWTGRESIEEEDPEVFSLISKEKIRQSSGLELIASENFTTRSVLEVISSCLHNKMAEGYPGNRYYGGTQYVDELESLCQQRALKAFKLDPAQWGVNVQPYSGSPANFAAFTALLEPNDRLMGLDLPDGGHLTHGFMTDTRKVSATAKYFQCMPYKINPQNGLIDYDQLLEHARLFRPKLIIAGTTAYSRLLDYRAFRQCECVVCPQAMQPEYRAYQQQVLKNAKVMSQALVDRGYFVVSGGTDNHLVLIDLRPKGTDGARVERVLELCYITVNKNTCAGDRSAVVPGGLRLGAPALTTRGFRESDFVRAVELVDRGVGITLDAHRRTKTLNEFKTFVLEDSEIQQKIATLKEEVQTFAKTFSMPGFTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTZ2</accession>
    <name>A0ABM1VTZ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Zinc finger protein 271</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101857801</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099257.1">
        <property type="nucleotide sequence ID" value="XM_005099200.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825884.1">
        <property type="nucleotide sequence ID" value="XM_035969991.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857801"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="680"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005099257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035825884.1"/>
        </source>
    </evidence>
    <sequence length="710" mass="80977" checksum="5C7B1114B84419C4" modified="2025-10-08" version="1">MGSKQRRLKSWKLKLRSKMKKLREAQMAHKAAAKFSKTLQPEPPPPPPPPSGVGQPHLEMLTVSQLQDQTANFGNNDGLVRSQPALEIENSTIEKHIQDPNTKATPFADTSNFVFEKFDRSGCVIVTTDSGQPMTVVFEKNIHIQVLFDPVKMAAISVSDPSSALLAFTPKGEQQLTEVEEMSSVIIENAISGLERDVISENDLLHIQRGEVASSDQMDKEKSKNPPRRKRKQSKVVEEDECYCHYCDLPLRNRSKYVSHLQKKHPNRRDSKKLIKEFSKVKNVEDSDSSDSVSESIEDLSKVDETEMLECGQCEVSFRTQSGFDRHRKWHLREKNGGEIPVVDKQNLIEQEESVVDDNNQGLVDETEMLKCGQCEVSFRTQSGFDRHRKWHLREENGGEISVVDRQNLVENEEPIGDDMNEELSESSEEGHSTKAIILQAAPAKFACSFCEEKFPSLLTRKKHIQLKHPDELKCKYCGIIFVSLSACETHCKTHGPFCFVCKQLFSTWGNLNIHWRDKHLDSVDAEGNKIFEECPKCILVFADKKKFVKHLKYHERYEQRDKYVCHVCAKVIQSGSAFQTHVRSHNTDKGITDRIPCDQCGKMFADEHALNNHHAKLHRAKPYKCKVCSKAFALSFHLKRHQYQHIAGRPHQCSLCQKCFSQGHNLAVHMRTHTKERPFSCVHCSQRFSHKCSLQGHVASKHNSDTLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VU09</accession>
    <name>A0ABM1VU09_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118477763</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825901.1">
        <property type="nucleotide sequence ID" value="XM_035970008.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477763"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="71"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825901.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18967" checksum="840FB2A151D93A1D" modified="2025-10-08" version="1">MPPRQKLNEFDRTRAIAWLQYGVGVREVPRILQLSHLTIIRLRQWFAVTGRLLERRRKGRPKKTTVREDLYIQHQATQKRTSSSSVFRRRLRAATYTTVSSQTIRNCIHDVNLRARRPVRKPTLTQNQRANRQIWCTAHQRLTNAQWTEVLFTDESRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VV80</accession>
    <name>A0ABM1VV80_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118477875</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826322.1">
        <property type="nucleotide sequence ID" value="XM_035970429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477875"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Agglutinin HPA-like"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <property type="entry name" value="ZGC:101858"/>
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        <property type="entry name" value="adh_short"/>
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        <property type="entry name" value="DHBDHDRGNASE"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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        <source>
            <dbReference type="RefSeq" id="XP_035826636.1"/>
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    <sequence length="151" mass="16730" checksum="706458B5970A618E" modified="2025-10-08" version="1">MSEGWPETGPGSSSGLGQATAVLFAQRSCSVVLSGTNEKRLQETLEKCQKAGLKRDQILTVAGDITTHKTREEIVTRTFGKFKRIDILVNNAGALYTGFIKDLEEKDIDTTFNLNFKVPVLLSKLVFPYLKETKGTVCPMERSLSLRPFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZ69</accession>
    <name>A0ABM1VZ69_APLCA</name>
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        <recommendedName>
            <fullName evidence="2 7">Phospholipase A2</fullName>
            <ecNumber evidence="2 7">3.1.1.4</ecNumber>
        </recommendedName>
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        <name evidence="12" type="primary">LOC101850745</name>
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        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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    <comment type="domain">
        <text evidence="7">The N-terminal C2 domain associates with lipid membranes upon calcium binding.</text>
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    </dbReference>
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        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FabD/lysophospholipase-like"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PLA2C"/>
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    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="547"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1873"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2148"/>
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    </feature>
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        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="83"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
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            <begin position="144"/>
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    </feature>
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        <location>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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        <location>
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        <location>
            <begin position="1782"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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        </location>
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        <location>
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        <location>
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        <location>
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            <end position="2096"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362102"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
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    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
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            <dbReference type="Proteomes" id="UP000694888"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="2219" mass="246707" checksum="BF56D0E939EED055" modified="2025-10-08" version="1">MENGGEGSGYVSSRPTPPTTTAEQNNGESLFSFSGFPTSISSLTASLHTPPSSSSSSSSSLLSSTTPSTQHARSLLTGLSSSAHHKGQRHPPTAAHHHHHRPHRLRKVPAPTQSVKSMAHTLRRLASSRSFPSSYPRTKLSVTQEEDEEDESREREENEEEEKMEEEEEEEVDEGKEENGNESCRNENETGGLRDEKMSTLQNCDVTSHKWTQGSDGEGEGSRNQRTDSDPNDPYCANIPIPTTTTTTTTTTCGSTAVDNQIACRSNPVSAHNTHEMYTNPIPELSDPVSNFLQRSTSDVNANIREPIASNVQEPRTSPNFNESSTFNFHDQAQASNFHELGTSNFREPMTSNFHEPETSYVHDEPMTSDFHEQVTSNLHDEAATSNFGEPAETTTVTAPKPPPPHNVQPLLSTVLRKQHQQGRRRSSAFDKTDSLGFQVDGQSSPPGRGSLEIGEGEEKEEGRDSCDGGGGDGENRFFWADGSGDDDKAKCDSGVISSVPRNDAGGQVENTREVKSVDMVPDTEVRFDGNYSFRFPDTSRDVLDLQRGSGERSWSPSPRIGKNSTANSHEDDDVFAAAPRPSTSDDITTSLVNARGIDTTIADDDKSKTARIQSPDHDSNNKGRDSYDISTTHNSNNDMSTSGNGENPGGGGGGGQFVFQKPFPVPESAAPKTTTTTATTTPGSGRSAPPPPLFRRQLSKRKSETNIPDLLANVKDADRKALRSDEPGDYDLDDDEEDDEEEFHSLGSVCHTPTSPKAPRMETYDPYQYFEVQHTPCLILTVRVLRARNVTLGFRDYYDTPDPYINLVMRSSPEGRKSTTVKEDEPNPEWDESFTFFVNFTQANVLEISLMEYNLLWYHQVVGTVHFDLIHINQMDVFQYETFVFNDVTEVDIEFKLEFDRYPTLRYSLCLSDAEKQFIERRKAKAMEGVCNLIGEEDGPVNINEVPTVAVLGSGGGFRAMTAYSGVVKALKESGVLDCVTYACGLSGSSWLLSTLYSHPKWPNVDMAEFQEEMKQNIDKRLLRFFTPATMYKYTSYLVKKRREKQPVSFTDIFGRMVGETLLSGRMNATLTDQRETIKDGDIPMPLYTCVHVKKDVPARQFQEWVEFSPYEIGMPKYGTFMDSELFGSKFFMGKLVKKFDEQPLHFLQGIWGSAFCILFKRLLEDNRRLDPAEMMRREMGEQMLREEIGQELDEARGESSSDCSDDEIDFDSQSSIDSDAGATTGEENFRKESSVESTSSLDSQNSQDFNRVSNERRSSSQSLPTVEESNPNAQDKNGLVFNNPANDDEEEGKSGNESDMEDDEDEEDDELFKSCRFENRKGSVEMRKIEKMKQGSEELESQAPGNKLLDVVAENNDESEDAKKSVRWGACPTRGNVSKEKREAFRRASSSMRKSRSGSKSYWQQYLKSMVESKWELFSTRRGRAAVIHNFMRGLSLQQTYPLSPFTPVEKRVKEGDEFDGIFEMHPTSVKHLYMVDAGLTFNSPYPLVLRPQRQVDVILSFDFSARPSDQHQPFKELLLAEKWARLNRLPFPPIDASVFDREGMKELYIFRHPTDPHCPVVLHFVLINKDFRHYKKPGVPRETKEEFDFADFDIFDNPKAPYSTFNFTYSHENFERLSKLTEFNTLLHIEEIKQVIRDVVRLKREGPPRIPIQSKDIKLLHMKSVQEYRKLKKFISRMESRSSISTPFGTPGVQASPSTNPFFSDLKQDKLSRSSTCSSEQRHWPDRLSESHNSGLNSHRSSRNRGRRSPLSSTSSCDSVFGTPPQDQVPTFGAPGQPHNLQRQSSRGVPSNVDSSHVTGQKNSNSRQMPLFGSSAAETGILSNSCPQSSVMRDVTDSRSHPENGRHEAVPVVTATTTPAQNFDMLDSGTSLVLDDQSPFSCPSSLSPSTPHAIPSPNEAPKSPAGSSPKLKMPPLLPPPNVAQTLSSSSGSSKSFTPTSTPSTAQNTPKPKSKKELPPNPFFVNAHFMRSAYNSSSSSEGGDSEDKGKNYRLTTGSSYRRSKPSPLANGLPSHSSANTERSESNTSASSSENNHITRGSPAGLSTFHSRNLESHPELVYESSPSQTESVEGTNTQTSVTSQEPSTASPTSDDFSLAPEAFKLDGTPVTDRAQAKMFYEEAKKKRALFRRQSTVSSLNSISLEDRCQSQEVGEQDIQRASSGDSVTEIRPVASDGHHLFQDAFHSCDEGAPTSVTKEDVISMEISNLSQFQAVGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZN1</accession>
    <name>A0ABM1VZN1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Photoreceptor-specific nuclear receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106012891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827874.1">
        <property type="nucleotide sequence ID" value="XM_035971981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012891"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="126"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035827874.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21008" checksum="482CFA1859D3FA83" modified="2025-10-08" version="1">MTAVATNMFQEQNEKLDVRGFEHHGMAPYPLTPSSQSVFTPQPIDMHCPSRGRTGSRTPSPRRSPRGDSPVTVSVTKSPSPNTSCTSLTTEVCAVGSPAGSDVSLSPSPGGGPIKKNTPGMWAAGGLLCVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGLCTVDKAHRNQCQACRLKKCIQMGMNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W014</accession>
    <name>A0ABM1W014_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GATA zinc finger domain-containing protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828007.1">
        <property type="nucleotide sequence ID" value="XM_035972114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855520"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47246">
        <property type="entry name" value="MUCIN-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47246:SF1">
        <property type="entry name" value="MUCIN-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047357436" evidence="4">
        <location>
            <begin position="22"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="956"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="515"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="664"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="802"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="895"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="959"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828007.1"/>
        </source>
    </evidence>
    <sequence length="1186" mass="128622" checksum="F23394B57307D46C" modified="2025-10-08" version="1">MKLAWTLLLVTQAWIFTGSHSFSHVQRTDANLLEEAPNDGTAVDKIVRSKDTNHHPDYRLQDNSNVQNAEAHRQREAGQASQTGAEADPKEPKRVQPSGDFQSLLFLMWTKNATSSQPTTNVADSELFSKVQPPDEGFREEVEEKMPYVRKLAKKYTHGNSLLSGSNVGNNGLLEDGIETDSTLLYLTEDVEKNVALSDGRFRDKQKKEVNRGKGKTKITNQQRRRRSATSKFTGLVVGSSKNGKLDESVKTLLSTLYQKVWELQSDVTQQFQAAGGKDGGVKYASILGLFPSYVKDNFHGCEEETSFRADKTYSVPDVNALGTLMVLHCLAEAAVYGKAGVPDVGKMSRAVEALEEFHTRNLEKGNTIMTMWPEKLRKDESGWVIYPENLAQAPVKGGTTLNKLQTLVKKSESCTTAKTGLKKIKECKLCADHYNTSLADAVYDVSTPPDLMTSFSNLALGSLFRAKFKGGDGKDQSVFRAELETWGHTNSDFGLLLKKLKEMAIIFPVKSSETTTKNPTTTTSTTTTTTTTTTTTTTTTTPTTTPTTTPTTTPTTTPTTTPTTTTTTTTATPAPTTSPTTSQTTTKTTTTPSPSPPTKATTAPSLSPPTKATTAASAPPPPPPTTTAPPPAPAPTTTTTLTAEDRDSNSKNASTNEQNESTNSMGNKNSNISSSKNNNNNNNNKNNKNKNSNISSSKNNNNNNNNKNNKNKNSKNKDNGNSNGTIREKSKPPSNQDEESSTVKDGKSHGSINDKSEASNPEKHPTHENKTHAQEKAKKNKTNSGVKATVKTPDIKLTDGNNSNNNNNNNNNNNNNNNKINGSDTSVEVARSNREAVTVTVSSEVKREGKEGIGGNQKTNTIDTGSSKPPAKQHTGEGKRNAGSVNAGKSKGNTNDEKKDKSKVSSDSGDHDSKRDNKRAGSKAGNDKATDATVIGSKNKNIEVKIKVNNNITVNKGKSNEASKGDKNKNEKDSEKKKQNKNNNAATTPTTNNSVNKENHSTTTNKSSSNNNNNNNNNNNNNNKTSPKNVPITKENTGRKKKKSHMMPAPSTTVTKKPFEGHRNQILDSVSYFGLRKYLDTAQTSDNGDVILVPLLISDSPKAGFEPGDLRHNGQASRRYNSVDLTTMATTLHALVVSSMTGLVDIGEDVELQVCILYVRVLMFVCTQENSPQPRELTNPDFCQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W053</accession>
    <name>A0ABM1W053_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101856290</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828046.1">
        <property type="nucleotide sequence ID" value="XM_035972153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856290"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828046.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33588" checksum="08B9E84829BE9E34" modified="2025-10-08" version="1">MSGWASLSGYLFLKPGGGGLSILKARKRLWCILEESQGKLLYYKSEEDARSKPPLGYVELRGAAITLDMDNHNQFVIIVDSKEILLTAENHESMMIWMMALQARRDQFALGEKSRTSSTSTDNDLDPDPSQLDVGGPRERSSSDLTVVRDNYTGQLTVDRFRHRPLEATKSLQGQQLASLALLGRSPEWRRNQLKKMGDTIDNGHPSLKNSPMNFLQPQTRQMSLSMEMAEIVQRTQPPASSTAARAAATNAGAAILNWSSSNSNSSNSNSMDTGEELYTTDNGHRIVVRSASARGSPDLRKGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0Y8</accession>
    <name>A0ABM1W0Y8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Tau-tubulin kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC101850365</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108547.3">
        <property type="nucleotide sequence ID" value="XM_005108490.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828331.1">
        <property type="nucleotide sequence ID" value="XM_035972438.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828332.1">
        <property type="nucleotide sequence ID" value="XM_035972439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850365"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="678"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005108547.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035828331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035828332.1"/>
        </source>
    </evidence>
    <sequence length="888" mass="97064" checksum="CC63360881EED048" modified="2025-10-08" version="1">MTTTAEDLLQVNQVVKDRFKVVKKIGGGGFGEIYEATDLISRELVALKLESARQVKQVLKMEVAVLKKLQGRDHVCRFIGCGRNERYNYVVMSLQGKNLAELRRSQTRGCFSLSTTLRLASQILRAIEAIHDVGFLHRDIKPSNFAMGRQPNHRHVYMLDFGLARQYTTASGEVRQPRSAAGFRGTVRYASINAHKNKEMGRHDDLWSLFYMVVEFVSGQLPWRKIKDKEQVGIMKDKYDHVNLLKNLPSEFRAFLEHIQTLDYFDQPDYNMLSNLLNQCMRRKSVRDSDPYDWEKSNADTSITITNTSALHALKQTNVHNVGPITPGHGATEVLDENLSYQDGEEPLKRPELIPLNEVDNRYVEEGVVVLSRPDADTPPAKYEQDTKAKEKSKDTEKGKPQERSEHAHKKGPHPEVATPKENGTRSGTSTAPKPHSTGSTRGGPPGGASVDAASTQAVSKVGDKEVVPSPGDRLPPPGPSVGHGLPSSAYQGAGGSVAGGRGRVLRLHEVAETSGLELTASDKVGGVTGPPPGAMEAGEPSNENENMRMESGPDLASRAAITFALMQTDDKTHTQCDEAGEENATRAAPFTMASQWGAFGSSDEGSDASDVDGGGDKGRKSARGRRQATMNTLADEDDHQLDSMARNSLVLMEDRDGHETMRASLVFEEDSTELIKLIQSAASGGRGEEAPDDGLETPGRHSEHRHPHSHHHTHSQDKSYSSPRKMPEKLAKDIDNRIGSPLRNSSSGSPSKFVFKNRDSVDEKRRSKVVALGKPPIHASTKREKSFDGATGLASELGRQAGSTNSLSSNRDRESSLPSSKPKSILKDKNASMSERNSNGDNRFLGEASAPSVEPTSADGRVIVTMKDEPNLGTPREQSPRRPPGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1G5</accession>
    <name>A0ABM1W1G5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101846692</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101846692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828508.1">
        <property type="nucleotide sequence ID" value="XM_035972615.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846692"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035828508.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20876" checksum="CACA04009D7F757E" modified="2025-10-08" version="1">MAHRLPAAGILTEPSDSFRNYQVWPAPEKKCKRKEEPNPRCTLRPKFVCTTRCEERTFRPPPPLTQPGLLCFEESMKSHCHGERSGEHHDQVHYTQHGNHHRRRHHSEHHGRGCHAHRCHHPDLVCFPVPRIRIVKGRNTREKRRLYRSCVEIRDTTTSALHTKHDPPTSCESGLEQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4Y7</accession>
    <name>A0ABM1W4Y7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Coiled-coil domain-containing protein 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6 7" type="primary">LOC101855166</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091737.1">
        <property type="nucleotide sequence ID" value="XM_005091680.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091741.1">
        <property type="nucleotide sequence ID" value="XM_005091684.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829730.1">
        <property type="nucleotide sequence ID" value="XM_035973837.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829731.1">
        <property type="nucleotide sequence ID" value="XM_035973838.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829732.1">
        <property type="nucleotide sequence ID" value="XM_035973839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855166"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829732.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="8731" checksum="04CDB5FDABF2C097" modified="2025-10-08" version="1">MPKRKATKAPANDAATNDEGETAASPAKAQKKVATPKPAEKKGRGRPPLSAEEKAKRAEAKKQSAGRGRGRPKGSTKKSPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-10-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q06AD3</accession>
    <name>Q06AD3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Pheromone isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Pheromone precursor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative pheromone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4 5 6" type="primary">Alb-1</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2008" name="Peptides" volume="29" first="152" last="161">
            <title>Characterization of Aplysia Alb-1, a candidate water-borne protein pheromone released during egg laying.</title>
            <authorList>
                <person name="Cummins S.F."/>
                <person name="Degnan B.M."/>
                <person name="Nagle G.T."/>
            </authorList>
            <dbReference type="PubMed" id="18190999"/>
            <dbReference type="DOI" id="10.1016/j.peptides.2007.07.031"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="2">Albumen gland</tissue>
        </source>
    </reference>
    <reference evidence="4 5 6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="DQ924535">
        <property type="protein sequence ID" value="ABI96181.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191460.1">
        <property type="nucleotide sequence ID" value="NM_001204531.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939688.1">
        <property type="nucleotide sequence ID" value="XM_013084234.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939689.1">
        <property type="nucleotide sequence ID" value="XM_013084235.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q06AD3"/>
    <dbReference type="GeneID" id="100533214"/>
    <dbReference type="CTD" id="100533214"/>
    <dbReference type="OrthoDB" id="6147660at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1 4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004165092" evidence="1 4">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABI96181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="NP_001191460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012939689.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13225" checksum="35BDF9620813D033" modified="2006-10-31" version="1">MRAIVTLFLLLVVVALTPGSRADDGDGDDSNSHGILCRSACDVAQDKTGEATQLIKYMCRCLGWEKFSTTAFPTTITPRRVKPVTTDLPSSPPEATTNICDYLCSVQLGGDACQCSNPSLPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA20</accession>
    <name>A0ABM0JA20_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101861244</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005088897.1">
        <property type="nucleotide sequence ID" value="XM_005088840.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861244"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06894">
        <property type="entry name" value="PX_SNX3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005088897.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18665" checksum="9FAB18EBC1398824" modified="2025-10-08" version="1">MTTPTATARISSKKQTLEDAYSPPANFLEIDVSDPQTHGVAKKRYTDYEVRMKTNLPVFKLKESSVRRRYSDFEWLRNELERDSKIVVPPLPGKALKRQLPFRGDDGIFEDEFIEDRRKGLEQFINKVAGHPLAQNEKCLHMFLQEPVIDKNYVPGKIRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAD8</accession>
    <name>A0ABM0JAD8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101849014</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005089113.1">
        <property type="nucleotide sequence ID" value="XM_005089056.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849014"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="45"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="235"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="506"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005089113.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="64355" checksum="2454DF12D1362022" modified="2025-10-08" version="1">MASTSVEDEDEHTVQFHEMGVDDRILEAISKLGWSQPTPIQEKAIPLALQGKDILARARTGSGKTAAYAIAVIQKLLHIKQTAAQQATRAIILTPSKELCNQAFRNILELTVGCSRDIRCTDISPQVPLASQRSVLIEKPDILVATPSRLLAHVRAGNVDVKESLEMLVVDEADLVFSFGYEGDIKELLDNFPKIYQAFMMSATLDDDVKSLKKMVLHNAVVLRLEESQLPEASQLNQYHIKCEEKDKFALVAALLKLNLVRGKTMFFVNSVNKCYQLKLFLEQFGIRACILNSELPVNSRCHIVNQFNDGLYDYIIASDETTTEGLPAPVESRQKQKSKRFRKQDKEYGVSRGIDFYNVSNVLNFDFPKTSDSYIHRVGRTARADNQGTALSFVSIKDAEKLKKVEEALSGDNSDDAENVFKPYNFKMEEIEGFRYRAKDALQAVTRTAIQEARLKDVRQEIFNSDKLRSYFDDNPQDLQALRHDKPLHTVKGSKELKHVPQYIVPQSLRSQSGGSRRRNRDGHSGQHKQSRPAYQTEKKFMKRKADPLKSFEFAGLADKKKKKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDA4</accession>
    <name>A0ABM0JDA4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamine amidotransferase-like class 1 domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ferry endosomal RAB5 effector complex subunit 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Parkinson disease 7 domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005091062.1">
        <property type="nucleotide sequence ID" value="XM_005091005.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864196"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF18">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE-LIKE CLASS 1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045194810" description="Glutamine amidotransferase-like class 1 domain-containing protein 1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005091062.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25196" checksum="31B20A3EB122D264" modified="2025-10-08" version="1">MATSRGSCLVVISSAVEGVSAASFMQACTLINQTFAIQLASPGGRQAEYVNQDDSNRRWFNEFRSKASSTPIGLETVDVNRYSAMLIPACPGAIHDLAGNKDLSQILVHFIKEKKPICAIGQGVAGLCPARREDGKSWYLEDFCLTSPSLFEVGHLPEFLTMPIILEDFIKDHGGKYTATEPDGVHVVIDRFLITGQNTQSTVTAVQNLILMCSQKQSRPGSLSRYPSQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE42</accession>
    <name>A0ABM0JE42_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM and LDL-receptor class A domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091598.2">
        <property type="nucleotide sequence ID" value="XM_005091541.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860949"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046450963" evidence="1">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091598.2"/>
        </source>
    </evidence>
    <sequence length="190" mass="20628" checksum="310F58CD83BBBC81" modified="2025-10-08" version="1">MNVLLTAWAILVVYFMSHSVNAENRIGCNFEVDLCGWTQNTDDDYDWRRNSGPTPSFSTGPSGDHTLGSASGAYIYTEASFGIAGETAKLTSDRVTLSSGDGCFQLWYNMYGAGIGALNVYLMPSDGPLKSLVSLEGEQGRDWRMLSVNISSTDFRIVLEGVRGKSFMGDIAVDDVRLTDRPCGDPQLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE97</accession>
    <name>A0ABM0JE97_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty acid-binding protein, liver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091721.1">
        <property type="nucleotide sequence ID" value="XM_005091664.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851787"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005091721.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16266" checksum="9953648101758855" modified="2025-10-08" version="1">MVDKLFGYWKLEKNENFDKYMVENKVNMVLRKVGNTITSYEEISREDDQWTINITSTFKSTKLVFKLGEPFEEKTMDGRTMKSTFSIEGDTLVCLQDPIKDGDIPSRFVREVNEDGKMVLTCIAIPTNVVAKRYFQPCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEB9</accession>
    <name>A0ABM0JEB9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101863721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005091771.1">
        <property type="nucleotide sequence ID" value="XM_005091714.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863721"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="171"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005091771.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41603" checksum="7D47C19B858206F7" modified="2025-10-08" version="1">MATGPDSDDDKRLKFGNRLLTDPQNVFQHNAWDNVVWDEEQEAAAKKITEKQLECLAQPEKKEEYESKADEFWNTFYSQHQNRFFKDRHWLFTEFPELYGRKDCDDNNDSNDSLCKPQDGENTSGSNTTVSSPQQSSGELDESCLSTAVDKKCSLVDGATAPCDDYPVNFLEVGCGVGNTVFPLLNTNKNPNLMVYCCDFSSTAIQILKEHPDHDQKRCCAFVLDITEENPEVPFPTESLDIIIMIFVLSAVCPEKMQAAVNRLASYLKPGGTILFRDYGRYDMAQLRFKQGRCLSENFYVRGDGTRVYFFTQGELRNMFLKAGLLEKENLVDRRLQVNRGRQLKMYRVWIQCKYIKPVNPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG43</accession>
    <name>A0ABM0JG43_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101844984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092908.1">
        <property type="nucleotide sequence ID" value="XM_005092851.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101844984"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="140" mass="14938" checksum="F98238EEC3A9ABE9" modified="2025-10-08" version="1">MPRGRGFGGGRGFGRSPSPPRRSQRPTPPPPRRPPPPRRPAPYTPPRGGGAGIGGVIAGSFIGSALGSVLGNAISSRMFQGRDPDTGQYVDDGPDRNPCSRELDVFLACARYADDVSYCQKAADALKECADKNKDYFQDM</sequence>
</entry>
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    <accession>A0ABM0JH80</accession>
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        <submittedName>
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            <begin position="1125"/>
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        </source>
    </evidence>
    <sequence length="3039" mass="327485" checksum="2E28A7CE1FB09F6E" modified="2025-10-08" version="1">MECDGEDPSSLLSLRETLLPPDTSSSSSSQVLGHGQLHNWTASIGQSVDISGQFSPVSPADGFSNGQNHGEGAMRFYGYHRASAQDGSRNGELSVQGQFPVQNRAVNNGNLSNSLGGFVSSSSHTTTNSCSTLYYTEPDFRPDGDLYSNKDGSRHNSVNGGSDPCSHRVAISQTSMRPPVSHVSQPFSQTLEYTLNAEMPDPNKAGSRSVDLDQSFFDSRMKAGDFPKEMENMYDASTSKQSSKAMAGQDSSLTFDRRQMDISNFDTDFDFATPSRDYGTSAGRVDLSSLHRGAQQLAYHQSMASMDSSSHVTIPQKYSNTVPMSDSNQQYTGVSLPVDSSSPQQPSDELKRVHMAYPSFSFGDNSDFESLRLAEAVQKKPSLSQHFGSISSDLDPVFHATPADVSSHHKYKFDMGKTATSDEFRETVRNPRSSVKETDETGRDAGKWNGRPRAHRKMARLLGGGGLKMRHGAVEVASTSVGAALHAGVEEGGYETMKDQHALRTEVQGKVAYHGGENQRDVTNNSRTFLTMEEELELRASEHEQRRLTSRSRADDADRQFALPKESGLLSSHGLTLDPVSFSMPVMHKDSSLLTDHQFLSGPQLDLDLQHSLTTSSQRELDMNQQLALQVHKDFDMDAGHAAAGPDDLSFDSPMDPAHTGEAELAFSDMNIGGHGQQDLPLEAYFGTGVDRDITFSRKIQTQLIRDIGCMTGSADNDFNFEEYMNSQPQRDLSQPYFDRTDIPQDMTLYQKSPSEKMTVLPDTSSIFKEREKNDGSDLNSMKQMREVSELQKELTKTSAKESMKGIRTPRDLTRALESLQENEKEEARLKEQQQQQQQQHQQREQLESQQQLHQQQHPQQPVSSLVSSPKKTFQTKHQLESMALADQHFLGSTSGFMDEAPVPGLLDSPSLSLSNQHNSAPENPPMMSHYQAFPFLPPPPGEIEMDPSIGGGNKRETSIGHSVNSELDNHILKRLALSSVSHDTASGPPSLPFPSHSASMESVLLETDSTATVDSDVSFQLPVMSGFHNEQTTSETMTDKFIPPGNTATDTTRPRQEMAPMIEFAVRQLLTSDRMHTLTAGSDHRSDNMSTMTQSGLSMAKRESEILSSSRQNLYSMMKQEQFCDAVLSTPNISIKVHQVVLCSLSQELTALLHTMRPPEPSQGSSPSVMLVVNCDSIKSSSLSTFLSLVYVGHGPLTHTNVLDVYVLASSLRMPSVQKLCRDVMTHMRISSSQVKKPQLVVSTPVLKKRDKSCSTDATAAAGGKVYEERAVNTGRWDWSMDASTQTDRSTSEAGERGQEEWVMLKKTKQKTVSPSKSRVLGVKVGVSSDNNPASSQTALKVGKKGCLSPKQTCTSDALMESVSVSGSGAGEILQLSSSATVCPSGKGKDSCVGIESKSDSNSRLEESRIPCVRDRKPNVDDVIVERSTTSSSSSRADGERKKSCFVSSPSVEPKTARTTVEIAEAAAAAKLSAHSYGTRWARGGNRNFVSYAALASGLDRKKVSTGQREKPSSLSKKKEFIKSAARNEMAVCGSELSTPVRSGSGHSKIENVQNLEVLNSAEGKDPVSIQFGKSVGVTEVTKVPDVMMKHPDSAMVRQSAKRSFKKSIVHRSCSEEVLKDSIGKDNLQTKSVTAENARESVGDLKSIRSSSFGIPDRSNVSDSEIWEGGSNSVSHLLESIVNNMGSEDADLQKVIRDLDSELRTSPSSASGPPASASTLSVSSPLRSLQPPEVSPPPSKIKITSQSSTPQGFRKRLIQQMNSEKSGASSSMASSQQPLSQSIVNNAVLTTSSESNLLPVTFDSLIAASCDSGVSSACGVTSSGLSVNVSSVRDALMTSCMSVTSGQAPAKNFEAATTAPSGLQTLNVSSVGFGRNPGTEENSRQLVPATSSMDVSPLSDPLSAATGLRTSNKSPVSGKSAASADGSDRDLASREEDSHTFHHKIFKRNRRTKVKKSLLAEDVGLGNVKVKVKKLHLLEIDGGLGLSKVRQRKHTGSDTEGGSSSGRSKQKKSLSSEVGGFLSKVRPPPKKRAKMELEFLRASGRPSSDERLECDGSNKNVVADQLPGADVHNPMEKCEKLGRDSPGDNLGVPKASDSLQSCSVDPCIDSSLRSVVTKDPNLENEASEAERNTASLTAGKNTSSSVKGKHVSAVGGSGASNVRGKNTPAVGGNHLTSVRGKNNSTFGGNSAPNVEESDSVLDENESVCVLNKSSDPLSVQSDSVEEEASARFKQKDTLAEESFGSSSKKAERERMDGVVSAKGKKSAPSGQVRERSAVTVGTVKSSWLKGASTRAVPRKSFSKPMKRPTIAEKSKAKESTVMKKQKSKENSSKSRKVESVVLPSSADVRNISVETELTLLLEQRSKSDKPQRNHFICKLCQAVVKSARRTIKHVLNHGTEPDCVLEQVTIGQGKDVSQSCELCGYHSTVGRAYYLHYHRYFKHGMPLPPGWSSNRCDICDKECHTKFMLKEHQRTHQSQESGFTCPHCGQAFQNRNSFNNHIFHKHSKDRKHQCKVCEKSFKTWTQLKVHFRSHTGNRPFSCPECDYSSTTQGNMKNHLKGKHSFDDDRVNVIIKKLNQENKDLDPAGLAVAMQALVEKMKTDPSLKYPNQKRKSDGGKSGLKKSAASGKSGRSRFEGSRIQRLLTQPLSTLQPPTLVLPSVLKNEGVACSEKSSVRSGQVKSEKSTSVVPINTSTVAMPPVMSQETVSTTTAATATALLPAKSLLLPLSQSKPLPPPSVLCTVQTAAATVGVGGQESDSLLSCSVIPVQILPAPNLDSSSMMEIPCTVPHQTVSFGTAADMLASSVAVMNHHPHHLPTVHWLQTDGSPLTSVSAVTLPQEPITILNTGQGHSLLTGVDQVDSRVEINGSTASLVVLPGPAIAESSGAIAAVNSQLSSLFPTNPTACQPMIFPVTSDLCTVPTSVVSAVSSLPHHHMVQVDFVGGSGDGPDISELGGELDIGSGQEGSVAEQPADSTDVSPPEEVKLAGSADLLGVVTTDQSDDCDGTVAMCGEQPGSYANSHDAEFLTQVIVSSGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH84</accession>
    <name>A0ABM0JH84_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aerolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101846799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aerolysin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093610.1">
        <property type="nucleotide sequence ID" value="XM_005093553.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846799"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20219">
        <property type="entry name" value="PFM_physalysin-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.412.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055267">
        <property type="entry name" value="Aerolysin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053280">
        <property type="entry name" value="Aerolysin-like_pore-former"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34007">
        <property type="entry name" value="AEROLYSIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34007:SF1">
        <property type="entry name" value="AEROLYSIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01117">
        <property type="entry name" value="Aerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00999">
        <property type="entry name" value="Aerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047354510" evidence="4">
        <location>
            <begin position="22"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Aerolysin-like C-terminal" evidence="5">
        <location>
            <begin position="189"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005093610.1"/>
        </source>
    </evidence>
    <sequence length="592" mass="66277" checksum="A94F1B99263356CA" modified="2025-10-08" version="1">MAVIARCACLMFLLFASSVHGGCRRDNWWGSFDREGLSKCSNTGNEYVKGFYRNDRRNPDQIYLLEEAVCCTAPSPYRGDHTQIFYANWWGSFDLNNNWNNCPAGYFLQGFYRTNGHRLGNIEEGRCMKPASHPYHYGHCYDKDIAASFDNKGVSECDNDYFVTGLYRGGCDQLLCIEKMKCCKMAPRPDTINSLSKAKIRVMDKTMSDIATLAHYLGYGWCASCRAPYVGEDFRRQGDTWHADTRGPCSGYMNNQRLSMNYGHWKFSIKSMTFGTPVLQSLQPETMDTGVVDNGFPYDATHVITRSTDVTRSVTHTVTSDWRRSQELGVTFGYTPGLVGGVSASADYRFAYETSSSTSDSSGQSQTESFRVEESVTVPAYNAANFTLTISKTRRTLPYTAKILIHFSTELRGFLRWGGGPGGRLTNYHYQHTGSGSRPTVNYRFGDASVPFYEAVKEQSDSIQRPWLWANMKQRYGSAQNLINSLAREGRYEFTLTGKFDEVAGKDIRIEWGDMYPMPGRHRRSARAHAAVSASVSGTAPHNVVIHDAEVEVKKVVATEKPGDPPSEFPPPPVVALDPDSVIDLPKDIPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH87</accession>
    <name>A0ABM0JH87_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Probable tubulin polyglutamylase TTLL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC101847804</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093614.1">
        <property type="nucleotide sequence ID" value="XM_005093557.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093615.1">
        <property type="nucleotide sequence ID" value="XM_005093558.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847804"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005093614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005093615.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="48576" checksum="E78FB7FC642ED404" modified="2025-10-08" version="1">MSRIKFATDFDKSVLLNNFENRGWIQVGAEDDWNFYWAGVHNIRNVFSVDSGFRLQDDQVINHFPNHVELTRKDLMVKNIKRYRKDLEKEGNPLAEKDESGRFAHLDFIPQTFMLPADYNLFVEEFRKNPNTTWIMKPCGKARGIGIFLVNKLSQLKKWSRDGKGNSFTPPTAKETYVISKYIDNPLLIGGKKFDLRLYVLVTSFRPLKVYMYRLGFCRFCTVKYNASLNELDNMFVHLTNVSIQKQGDDYNAIHGGKWTVQNLRLFLESTRGKDVSDKLFDDINWLTVHSLKAVAGVISNDRHCFECYGYDIIIDDNLKPWLIEVNASPSLSATTSSDRIMKYRLISDVVNIVIPPGDIPDVRWNKVPDKENYGHFDLLYDEELANADQAGQDLRAKAGLPNPALRGGIREQRKGSQATWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHD1</accession>
    <name>A0ABM0JHD1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved regulator of innate immunity protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAM33 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093692.1">
        <property type="nucleotide sequence ID" value="XM_005093635.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863882"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005093692.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="31459" checksum="CA87896F8EF68B01" modified="2025-10-08" version="1">MAKAVKSALAAITKIVPGNSARLSCIPKQSGISARYLLGTSALSSPNTVATPRAHSTLSTLRSRHTKGTSCSFAHKQPIAFYSTEVDKEISSFLDKEIQFETSRSSDDLPKVSGFEVTTEGGDITLTKSKGSEKVIVRLSVNGAVDSVIAESAPEKQDEPPQMVCRPPFEVEISKGDGTVLALQCVFPSADEPFEDAEQYSKGDQEADRIEDQFEIQEVALHSGEWKDTTFSVSAATMDAELFDLLMDMLDERGVNDEFISQLVEYCTAYENKQYIGFLKGLKTFAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHN9</accession>
    <name>A0ABM0JHN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein YwbO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101847642</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093886.1">
        <property type="nucleotide sequence ID" value="XM_005093829.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093887.1">
        <property type="nucleotide sequence ID" value="XM_005093830.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847642"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="13"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005093886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005093887.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23792" checksum="E7342CCC3451E365" modified="2025-10-08" version="1">MGDAVGQKPEVKVDIVSDVMCPWCWVGKRKLESAMNDLASKYSFKVRWEPFLLRPDHPLEGVPKKKPIGGDMNDPGTVHLKRAGEGVGIDFTYKAPIYPNTVQSHVLLEFAAHKDGGEKQNEVAEILFKRYFTDGDSLTKSQLLEIAAEVGFDTAEVEKFLDDPSNSASIRRQAQNWSQNGVHGVPYFIINGKPAFSGAQDPNTFKKVIEKLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI92</accession>
    <name>A0ABM0JI92_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="5">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094246.1">
        <property type="nucleotide sequence ID" value="XM_005094189.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848875"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0385">Hypusine</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="6">
        <location>
            <begin position="84"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005094246.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16845" checksum="F32D651958B7EA21" modified="2025-10-08" version="1">MSDHEETFEGADAGASATIPMQCSSLRKNGHVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGLDLFTNKKYEDICPSTHNMSVPVVNRQDYQAVGVEDGYLQLMDDGGDITEDLKVPDNDLGKEISEKVEKGENIMVTVLKAMGEEMAVGIKNAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJT9</accession>
    <name>A0ABM0JJT9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TAR DNA-binding protein 43 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857099</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005095334.1">
        <property type="nucleotide sequence ID" value="XM_005095277.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857099"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12321">
        <property type="entry name" value="RRM1_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12322">
        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="106"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="232"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005095334.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="48230" checksum="622997CF1D0E3A4B" modified="2025-10-08" version="1">MAQYIQVVEDESDESIEIPSENDGTLLLTTLSAQFPGACGLKYRNPDTGAFRGIRLLDGVLHPPDGLWGNFQYLAVFPKVENKRKGEDGFDNPAAKTKRLDQQKCSDLIVLGLPWKSTEDDLQKYFSQFGELLLVQVKRDIKTGQSKGFGFIRFTAYESQVKCCAQRHMIDGRWCDVTIPNSKQSSSGHARGGGAGYDFSPYTHGSQGSYQFGAGYDEDGYAQEGNNQMMNRKVFIGRVTEDISADDLRGYFCKFGEVVDVFIPKPYRAFAFVTFADAETAQNLCGEDHIIKGASVHVSSAAPKSFDKGAERKGFGQAGYGQGGWNQRQGGPGPVGGKVANGAEGGMANNLGMNLLNSAMLAAAQAMLQNQGGWGGMNQGPSQGGTGGNMGGGDHQAPPPMALPSNQGGFGQSMGGGSGGGGGGSGGNWWGSEGSTTSGGHYGGWGGSHGGRGSGGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKE4</accession>
    <name>A0ABM0JKE4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101863336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095779.1">
        <property type="nucleotide sequence ID" value="XM_005095722.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863336"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005095779.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22822" checksum="B5176444444641D1" modified="2025-10-08" version="1">MSAARPRSSSRIVLPTMPSKISETQTVDIFKDERDGKLREVGNQAVWSLSSCKPGFGVDQLRDESNDTYWQSDGPQPHTVSIQFRRKTTVQDVCLYADYKADESYTPNRLSIRAGNHANDLTEIEQVELSEPTGWVCIPLKDSVDKPIRTFMIQIAVLSNHQNGRDTHIRRIKIRSPINYGDVPYPNTNKSALKNLVYTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JL77</accession>
    <name>A0ABM0JL77_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101850796</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096322.1">
        <property type="nucleotide sequence ID" value="XM_005096265.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850796"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045428482" evidence="2">
        <location>
            <begin position="19"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096322.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="31992" checksum="2E0ACCE6772F735B" modified="2025-10-08" version="1">MFRLLCSVLLLVVAPCMGHFWGGIHGGLLGGPFDGPFGGPFGSWPFPPPGLFSPGFPTTPQPIQVPQPQPQPQPQPNAGCPRVASACTGRAARISNSLVGDLIQNTIKNTDQNGDGTVTVAEQIQDAINSYDTKTTDGCVTREEWLAARRDLGFSDELSAALIDNYATPSCSGFLVGSLVSSPSESVDFYTNVQFQTLIDLCEGQQDLYNTSCNCAQLPASCRDNRFSGLASCSAYLPKITSRKECVFGNAPATPTTQGAPTGTAPGSTNLTNLQQICSQARAAGSRNPFLLRICATLPRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ14</accession>
    <name>A0ABM0JQ14_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cholinesterase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098856.1">
        <property type="nucleotide sequence ID" value="XM_005098799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862414"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="13"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098856.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16873" checksum="F3FBB5A27B8F660D" modified="2025-10-08" version="1">MVMELAKVVSYVPEKKHYLYQFNYRPSFSKAPQWMSALHGIEMLFLFDVRQQMFTDKGNGPPNAEDILVSQQIMERWTNFAKTGNPTSTVPNGGATWNQYRSTTPHYLQINSASQEKVLSPNEIINYYRQILDTLQGPSSTPIVPIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ84</accession>
    <name>A0ABM0JQ84_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854413</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098991.1">
        <property type="nucleotide sequence ID" value="XM_005098934.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854413"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098991.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="56903" checksum="6B7484B42828C888" modified="2025-10-08" version="1">MNKTGISVHYYNEGLFERIKESFMNFVEPSSFKLYISKYSKDVLNKFDEGEIDAEIKCRGVYNGAVMLLNKLTKYRGWFECAMNVLRDPDMKLANAAEEMETIKMNYDAELERSGLFLNSTGVQTPSPPVQYPTGEVGSDFSLLSANSSSASFENDADPDVLQGDCPVVPPYGNKEEFNNVTFTLKAPPTDDVPAAEKADGDENQSPRSEPPKRSKKLASDGPKRMSKTQDSAQPESSGDQKRQADPLTEGEARGQGQGNLNVTGDLPAKEVSEVQEKHILSSEAENLEGAVGGADPETADHEYMDITYSTEDLYTDTEPPAKLNKPPVEHAPPVPFHLSKLPAHLTKKVSEDEIEKKLKEVVARDLQRLRIDQHHGSAFDFTLEETEAALRNVRGWHKQIQEKDIWLRLSPFRQESGRYILWFWPRRKRPALCITHNGKVKTYTFHKTPEKGSSSKLVSYYMYKSQHKSKSLKDLVEYHLENGFVDENDKTLEDKTVRLSSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR14</accession>
    <name>A0ABM0JR14_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099511.2">
        <property type="nucleotide sequence ID" value="XM_005099454.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855793"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005099511.2"/>
        </source>
    </evidence>
    <sequence length="106" mass="12488" checksum="E71FF6DBBF28CD6C" modified="2025-10-08" version="1">MVNVPKSRRTFCKAKKCKKHTTHKVTQYKAGKASLYAQGKRRYDRKQSGYGGQSKPVFRKKAKTTRKIVLRMECTECKYRKQLPIKRCKHFELGGDKKRKGQMIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRS9</accession>
    <name>A0ABM0JRS9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase Mdm2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101847824</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM2/MDM4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100063.2">
        <property type="nucleotide sequence ID" value="XM_005100006.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847824"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10566">
        <property type="entry name" value="MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16646">
        <property type="entry name" value="mRING-HC-C2H2C4_MDM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016495">
        <property type="entry name" value="p53_neg-reg_MDM_2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858">
        <property type="entry name" value="OS05G0521000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006748">
        <property type="entry name" value="p53_MDM_2/4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DM2" evidence="11">
        <location>
            <begin position="78"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="622"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="565"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="241"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005100063.2"/>
        </source>
    </evidence>
    <sequence length="675" mass="71827" checksum="10C19B1502CFCC6E" modified="2025-10-08" version="1">METGRAPIPEGSAQPLIDGGSPSVSRIQVQSPLSTTVTVAAAHTSSLPSSCGSSDTVPTTTPTTQYVLEEKTTTVRVPMLRPRPALLKVLQLAGGIGETYTLKEIIGLVQEYIQERKLYDENNPHMVYCGADLLGEALRVQQFSVMEALGLFHRNCSLEPDSCIRIRRQLVTRAVTVPASDASSSGTALFSTAGLPASANTSLSSSLSSTSASGCSSVLSQLPTSGASNIPTEQVSCTPESSGSLSSSLPSSGSQASSQKSASSPQSVSSSTTVLTGATSPSVVVKQSELDAHLHTKEGDQVVTSTDSSSDGDENKRKDRKRKSDENQVPSGSVPRRRSTSVSVKCDEIDGGSGPWQCEVMVETSAAGSALRPQDDTVVVEYESDAFSVEYEVESSSEHEQQPPSQDAQGSGTSRDRGCSESDVSSSTSGTAILVVCKESDVEYLADYSDSDFGSDAELSDADKWFCKHCSIKNPPFQRNCAGCWSVRPDWLPVKGKVTRCEEKTDESCASASCDAVLSQESGLGSSKSTMEADQDNDLKSAVSNVATPVKDSVVSPVKKRKYSSCLETSDSQEDKKRPLSRPKLEGKEAGSRKSESSTDEHVKAKGKKKASSSLPNPADPCVVCLSRSKSASIIHGKTGHQVCCYRCAKRLKEQRKACPICRRPIQKVVRNYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSY5</accession>
    <name>A0ABM0JSY5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase tankyrase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100780.1">
        <property type="nucleotide sequence ID" value="XM_005100723.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855571"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005100780.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="61987" checksum="B2B8E72C2B573F03" modified="2025-10-08" version="1">MGQAGSKQEMFWEACGFGRAHLVQKFIEHGIDVNWVSSIHACSPIHVASQGKPDVVKLLIGASCDLTVQDSRGNTAVHHAAMKGHAEIIQMLADAGADLNAQEKNGWSPLHCAAYFAHLKAVEVLLKNKCDTGVLNKDGRSALVETARSKNHEDERVLGQITQKLIAAGCDVDLKCADLGEANFTALMFAAYHNHVEVADALIKGACDLNCVSLYTKWTALHWAADCGNEEMVYLLLDAGADPTCTGMRGETAADRAKDEELKEFLENSMKLFNEMEQVETASLSSAHSINAQASLDTAKALENLSTHAKNRDILSAPMPTIPALGIASRSDPTVRYTRRDVDEVAKTVNVVFPWRSYSKQASPSPDKDGLTGEGEERRKMFPSQDDKTNRFMDTLAQRINYMTSKIASMSVDEDADNEKKSSSEGTPTNDERAAGENSEDSGLSTRDGSRVASEVATPDNDGASKLNLDEPNLRPKSPKSPKSRDSAASAGSSKLSSPSKNGDMLDEKADACIIEESHRGFSILKALQERHRRSMCLDEAVVPSSPTAPSVVPLSSPGTTGEAAPAASPEIMSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUL6</accession>
    <name>A0ABM0JUL6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101853100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101872.1">
        <property type="nucleotide sequence ID" value="XM_005101815.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853100"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101872.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="53097" checksum="884ED29EFC11A7C8" modified="2025-10-08" version="1">MNNLGSDLNASIRADNMEGMGEPFLGFELLLFRRFQHHPALWYEWRERLWKRADPGAETLESACLTDDSALLSLESLEELGVGDIHQDLWYLSVMLHGRPKHLLEMVKQEIEREKCKRFPKAGETLLMRYLKLHQFTVLSLDSMFKFGDDNRLPREIFRCPNVKYLSLKYNGLEHLPCDIGRMASLEYLALTNNKLSVWSLPYSLTFLTRLQTLLLDNNLLDALPGFLTKLPCLKTVHRHGNHNYFKSTFMWYHTDVNLRIIAVPCEAQAHKKQESLQFWAAQSIIGSKSNFFESASVAPVLKDYIAEIYNLFNICHHCDKAQLTSANGYKVITFKNPYLGNTCVPFQHWACSLECARAVEIPARKEQISAARQLDQQYEDYIKECMRKFTSCRSPRHFLSFGSRESTEPRRASWRAGDVMEGQRKEVSRRRRRRDREKNKIVPPSDSSRTNCGCVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV21</accession>
    <name>A0ABM0JV21_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101846081</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102184.1">
        <property type="nucleotide sequence ID" value="XM_005102127.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846081"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046175080" evidence="3">
        <location>
            <begin position="25"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005102184.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="46288" checksum="0BB532D36602E221" modified="2025-10-08" version="1">MATNAVALFFLVILLSVAEHETATENVCAKWSQIATQLTGSGRTQTCTSPPAPNCTRLDCSGSIRFSHFMFSRHGQGPIAVDYCFGMQLNSCNSPISIDFYLVLPHWNIDHDIRISEDKNVAIPGFTIPLGTLGNVSPELDFKFEKQDDGNVTLSVKSKAKLNAYGTTMYVDQLERTLVDEETIPVLPCAHTIPDASSSPPKSFKERVCHQGEPPAAGAEASTLLPPATTVAPVKPPASKTLNQSCSLTSPCSQGEICDPASNETCQCQLEWKLMDDVCVTTSHHGSPCSHRDQCGYHEICTQQGSKGTVCSCEPGSGYDAVQQMCMRGETGTPEKNSSSSHPDVPAPAPHSGSGSGSEPGSQPAEAKTSPSKLPLIIGGSVGGVIVLALIVVANVYLFRRYRQRRHRREPGGGLLGDSDAPLLGADDDTDLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVD7</accession>
    <name>A0ABM0JVD7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101858791</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102417.1">
        <property type="nucleotide sequence ID" value="XM_005102360.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858791"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032707">
        <property type="entry name" value="MYCBPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421:SF1">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14646">
        <property type="entry name" value="MYCBPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102417.1"/>
        </source>
    </evidence>
    <sequence length="1048" mass="118187" checksum="15B215F4AA30F09E" modified="2025-10-08" version="1">MGSKQTSRDSTAKPGKKGKKAVTEELEPVPEPEPEPEPVITDPYAELRYVPQPPRPQCTYAPKMQDVFVLKRKCLPSISKDKDNTMIKQEASENETKSDAAPREKNKSSKRRISRPRHRDIVSCETMRPIEEIVWTSLSDQAMAPPLLSPWVFPGELPVTPPPLEILHKDNQQAPCFLDKLHSSLFKEQGGLELHDKAQEERLRIENYVISKTGRSRGKLLLRRSQLLPKSETDGLEKSQTTMERMETPDVFPVEAFFKVPIEKSNGLTYTLTKRERGYNVITDWLGCPEVTDEVLKELGTITRSLDPSSAQAKSQKGENGTEDGRNDEKKKNRFVPDIATLGVEGKQYNMAQSEIRALEGRTEAKGDGSGDIIPSEIHVHDGKIAGEVFASEGCKPNVMKAAAPRLSQVSLIFGNHKLFYSTDPERAKKKWVIEIGCSAEVGENAISSVFMQNTGTTVIHFNWVKISHDDPFELHRYDMEHFVFDYWGGTILSGEIFRVPFMYRSIGTGYFSEDWRLLTKPLLENGADIILRMWGVTRQYDPCFLARDRIDEDLQSRMTWNIVDNRLHKIMDYLPLKDSMLKDTRFPLNHRGPDLFHFNNPHLYYNTASVFRLGKLHEMLQLRKSKRQRLRGPPAEEDMTKLDSGEDSDTFISNSSATLPRPEVLKEPGEGEGEDMEASIQEVIEEYNSDLSLTHVTGTQSEIIEHATQVIRRRIDPDIPALKHVPESVSSTNSEAEGDGDEDPQASEKPTRKIPKAPINLVNPDFDVNNMREDILQDDESCEIQEALFSVMATEVDKLYFRNFDAKEDWKRTVCFTLLVQAVDNFSDFAVSLQRACCTAEAISKRQQEEAEAEEARLAAMAAESNESFISETVTEDVATKPKAQTKAEAAPKPATGKEAPATSRQSDVPEGDAEIDPDGEMGEAETPAPTDCLSIQPRHALDPVRFQDQYYGRLQSCMYHLLDDAFGKMDVLFATEKKEPISLRYSETGFTKIRDIPMPVDTDKILRAPLPPPWVKVAQMMDSTVAAIRQHREEVEEADHQADGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWQ7</accession>
    <name>A0ABM0JWQ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBL-interacting serine/threonine-protein kinase 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103337.2">
        <property type="nucleotide sequence ID" value="XM_005103280.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852707"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005103337.2"/>
        </source>
    </evidence>
    <sequence length="272" mass="31190" checksum="46A5D9EC93CEAB77" modified="2025-10-08" version="1">MSSVEQIRVIQLPKEVDVFHYNRMQYSSVLHQGQRSKIILARSEIIPDKKFAVKQMPLLSDEDRDRFSREMWLMKLASDIRGVVTLLPRPVFCGPTGYLIMPFYDKRDLLSRTGKLSDDNWMKVFVRAAVSLRSLHKKNIYHQNLRPENILLSTRHVAFISDFGAACLLSEGCDKVDTWTAAPGFRGPEADKEDGQLCPFQLDTYSLAVSMWQVLSGLCPVKNKPLDHLDNIPPQYAALLRNLLLPDPDMRWTLDKFLTEALELHPDLSCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXG7</accession>
    <name>A0ABM0JXG7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyroglutamylated RF-amide peptide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005103843.1">
        <property type="nucleotide sequence ID" value="XM_005103786.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852865"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="57"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005103843.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40396" checksum="5633B280806F2A10" modified="2025-10-08" version="1">MANKSQFAPEWVFKMGADTQVFENSEPNELVSREFRDVCEQSLQVFILFINVFGVFTNGINIRVFIRQGIASDTTTIGLSALALSDLLGCFFMIPASLCYVIKFLDYTDYRNCVALTSMPCHYPHVMFSRITCWLTVYISVERTLCVMMPLKVRFLLRPKVARNVVSFVFFFFVVFHIPFAANTRIVLEFDPAFNQSMAVNRETKSGQLFFYINSLLGTTILSTVAMLIVAVTTSVMLYKLKTTQKWRKSVSSVSTKSASSSSKEHEVFQTVTMVTAIYLVCLVGGHTPGFATLFFPGVSLSGLNKNLFLVMYTFKFFFDAVNSSVNFIFYIRISSRFKAAFNSIYNHNPRDMGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXI5</accession>
    <name>A0ABM0JXI5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101859802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005103873.1">
        <property type="nucleotide sequence ID" value="XM_005103816.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859802"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07852">
        <property type="entry name" value="STKc_MAPK15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005103873.1"/>
        </source>
    </evidence>
    <sequence length="571" mass="64005" checksum="B403D7AA93B72720" modified="2025-10-08" version="1">MSSEIEPHITKKYEIKKRLGKGAYGIVWKAIDRRSGEVVAVKKIFDAFRNQTDAQRTFREIMFLQEFGDHPNVIKLHNVIKAENDKDIYLVFEFMETDLHNVIKRGNILKDVHKRYIMYQLFKSTKYLHSGNVIHRDLKPSNILLDSECVVKLCDFGLARSLTQISMDEAGDPNLTEYVATRWYRAPEILLASHRYTKGVDMWSLGCILGEMLLGKPLFPGSSTLNQIERIMGSIPPPSRSDIDSLKSSYGASVLEKAASAAGRHRKSFDDLLPDSPADGTDLMKKLLHFNPDKRITADEALRHPFVQRFHNPAGEISLNFDVVPPLSDDIQLTVDEYRSKLYEMIIQKKAERRRRRREEARSAAMQQQQEEEYRQEEMVHEQPPKENMHSSPKRPSPKPVHKYGSLGEHPPQHHSSFSAFGRTASNDHPPPGPQRQKALSRQRSCENIQSSQATNGKGRQTSAPAAMRGQGRPVSGVHRAQSNPTITRVDERGGNGGGNGLMVASSRMVPGQRPTSAHNPRSKPAYGRKQFSNAMNNPSSGAPKAVFGSYSQAYGTISSSSLAALQGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYG9</accession>
    <name>A0ABM0JYG9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DET1- and DDB1-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101846372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104504.1">
        <property type="nucleotide sequence ID" value="XM_005104447.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846372"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033575">
        <property type="entry name" value="DDA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018276">
        <property type="entry name" value="DDA1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31879">
        <property type="entry name" value="DET1- AND DDB1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31879:SF2">
        <property type="entry name" value="DET1- AND DDB1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10172">
        <property type="entry name" value="DDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DET1- and DDB1-associated protein 1" evidence="5">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005104504.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11091" checksum="DB912D1EC90ACF18" modified="2025-10-08" version="1">MGDFLEGLPSYNESNFTRFHADSSHRSSKPTVYISTKDYPSEQVITTEKTSILLRYLHQQWDKKNTSKKRDSQKANLSEAATEGGSSSKVARVNSTDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYW1</accession>
    <name>A0ABM0JYW1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable glutathione S-transferase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104780.1">
        <property type="nucleotide sequence ID" value="XM_005104723.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850271"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104780.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23088" checksum="EA47D9B80F05E59C" modified="2025-10-08" version="1">MAGQTKLYFFDARARGEISRLVLAAGGKPWEDVRVAGGEEWQKKTKPTTPFGTVPVLDIGGKQYGQSLAIASYLAKQYGLYGSSPLEELVIDEVQQLREDLFRNEAAHFNEKDEKVKAEKAKVLKEETYPRYLGYFTKILKDNGNVFVVGKKVSLADLVILESTTTLIQNVPGLLDKYPELKAHRERTSQVPGVKEYLAKRPTQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ07</accession>
    <name>A0ABM0JZ07_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vesicle transport protein GOT1B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104868.1">
        <property type="nucleotide sequence ID" value="XM_005104811.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850427"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005104868.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15503" checksum="CA48835CB16D0C98" modified="2025-10-08" version="1">MMQITDFQKIGVGLAGFGIAFLFLGMLLFFDKGLLAIGNILFICGLAFVIGLERTFRFFFQQHKLKATGFFVGGMFIVLIGWPMIGMLVELYGFFLLFSGFFPVAVNFLRRVPVVGTILNLPGIRSIADKVGESNSMDGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZQ0</accession>
    <name>A0ABM0JZQ0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105331.1">
        <property type="nucleotide sequence ID" value="XM_005105274.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857587"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033290">
        <property type="entry name" value="CCDC39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24161">
        <property type="entry name" value="CCDC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="870"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="237"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="461"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="667"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="750"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="870"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="914"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005105331.1"/>
        </source>
    </evidence>
    <sequence length="930" mass="108350" checksum="FDEB60EAF52977F0" modified="2025-10-08" version="1">MSNMSNAVLAEIEWDEGLSMPVASAENKQLENEVQQKQTRIVASQNDLAETEDRINAMLEHLKNVRQELQHTQGLVTAREKESETEDHLLKIAQREEGRLKQEITRLKKEMDELKEKKNAFENTIFKQTQKLEELKSQMNWDQQALEAWLEESARKDEDAMTIQKYTRHDESKIKELSLRMEKLMEEALQKKHQLDSEMTSTLTSQIELDKIAEDFRKAHTERETLLSQWENTIEQMQRRDREMDILASQLAKAKQEVRRHNEMIREKQTFLENEQENNAEQEKKISLAERTSARLRNDLQEAELQRSQFEDELGTLKRTVDRTAIDLETTRSTVSMLRKEAQDKTNKLQQAKDLREALTEKLKVAVEATLSSEERAARMDELLNSEEKRQEECRTELKLLGEALFRKEKEKQEAKTDEKQTEAAINGAHNAIKNLNSKITKLDTDALKQQEILYSQDFTLQQLERRCIRMQGEHNTEEKAQLEAKVNQLQGDLDAKNQTHTLLTLQLKRLQDDLRRENRELEETHQEKADLTVKIDELNLYNENSEAELKRIIKSKQNLMVDENLLKLEIKKLRELLNSRADDVMSLEKRKLQLDTAMKERHQEIKIHKEMLTAQVKATDEERQQISAELHERISKIDKLKKRFEILMVSMAPPEGEEEKSQAYYVIKAAQEKEELQREGDDLDARIRKAEKEIRALENTLKLMNGRNEQYRKSFNKITDSSDEMDEKRQLDEQMRAVMDKYKYKRRQIRELQDDLHTMSSTLDNLTRDEDAYVGMIDEKKNKILQLNKEIEDQRTKLERVAKQNVRYSRELRSARKVKEELPEERDFQVRELREFNKTAMKMIGEATMHYPDMMEAVSMYFAQSNLPAPSASSVPGSARGSTRSSARGSPASSIKSGGSATPVNVGFDVGGSPRSSVSSARSQASSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1G6</accession>
    <name>A0ABM0K1G6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101857356</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106534.2">
        <property type="nucleotide sequence ID" value="XM_005106477.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857356"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005106534.2"/>
        </source>
    </evidence>
    <sequence length="483" mass="54241" checksum="D52F0F006769A771" modified="2025-10-08" version="1">MVLLRLKVTHQEYYTRTTLCQLYLCIPPPRDYFRLSVPNYQEWFQESVVFWLHMFRAECNTRVHRALEIDRDVNMTTLRRSFLSIEVLCLAIIFIPSHAEVIHKFATIDYEWPNATALAQSLANGDFASKTGVVSHSDVKGIPPGLTTVVKCADGKSVLRPYPNWDAQKIGDCSALQLPMSMAINPNTGYLYVIDIGRVGISSPNPTNLCPAKLIVYDTVLGGSTILSYEFPDSVVSRTTNYLNDIVLDYVNPKGACGVKYAYMTDTMTRSLVVYDFSHKSWVYKDPVSMGTDNDQDITIHGIIYPVDVGVGGIAMSPHFQLPLLLFCRIQEVVSRQVHTWVLRTPGNDFVSTTRLVGSKKSQGGGMVFGHKGLFFGALEYDAVYKRDMEADVISQGVSEGEAVMETQDPAAQNWQTMQWTDALSLDNESNLYFTTNRLQKFVTNKMDFDGGDGANFRIFKYNVHDKSYLFPAVPERPESIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K259</accession>
    <name>A0ABM0K259_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101856920</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101856920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106972.1">
        <property type="nucleotide sequence ID" value="XM_005106915.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856920"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005106972.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25927" checksum="D1E362734430326B" modified="2025-10-08" version="1">MNSHAPHHQSAGSGRRPHDCRIAMKFHPVDVTKIPVCPASKQSSTKPPFCGCPNDLETKCWKCCMPGVIETRLLRQPVECVKPRCNYSIPSIPCYDPPRHVADRCDPLCFEWTVDEPGPNDSYGLNGLNWYDWQMERRFSNTPLLESKTFGYKPAHPGFNIKPPLANTPIYVCTRPIECYARSENPCKTSPFATDINYFRDWRCCEMKPPQPWKPPYAHWATRVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2D2</accession>
    <name>A0ABM0K2D2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myosin heavy chain kinase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101849235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107107.1">
        <property type="nucleotide sequence ID" value="XM_005107050.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849235"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042280">
        <property type="entry name" value="SLC3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673:SF1">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Solute carrier family 3 member 2 N-terminal" evidence="4">
        <location>
            <begin position="119"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="205"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107107.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28878" checksum="A370E8D100903997" modified="2025-10-08" version="1">METSGISIISAKTLPSETAAVAYNNPAFDDDNGNTDAKNGITTATTAPSNTSTTTNNNNSSNNSSNNNSNNAPRMSSSDKGPRLYDDISHSKRGSSSVDFTMPEKKPRDRLKSLTTADGPYRGMGKEELLRYSSKPLWRNLRYVCMSIVLTGWLALLITVVALVLTYPQCREAQDREWWQKAVIYRVYVRSFLDAEGSDGIGDINGMHITVDFIPNHTSDQHPWFISSQANPDGRHNEFRSYYVWAEGGGPLKDTPINNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2K9</accession>
    <name>A0ABM0K2K9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glutamate receptor ionotropic, delta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101853815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005107292.2">
        <property type="nucleotide sequence ID" value="XM_005107235.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853815"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="35"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005107292.2"/>
        </source>
    </evidence>
    <sequence length="380" mass="43105" checksum="5A904F433012A947" modified="2025-10-08" version="1">MYAAIGIVSPLTVRKRKSNYVIGVLSEVEHGAQVLAASLVHQAQWTTPAIATRRIFLAFWWIFCIALAATYRGNLTAFLLVYKDVVPFNTLQELANQNVYKWGVIGSTVVEGLLYTSQREDFRKLGDGLKKFKAIDPEVVSLDSEVHRRKINRGQYAYISDMVPMEIWVAEDCDLRFLKETVMPLPFVVGLHNNSVYVQTFNGILLEIEQAGLYQMWKKKWWPSGGQCITGTQHGTKVVSLLQSQSAFYVLLIGLVTSILLLLLETCWNRKCAALDLDNSSQKNNSDNSQGESNPDDLYEKKTDLDTLSSTLKLKGSKPTQSHGGFDWTKDAKWSNYVTQFLTEDVATFSRREWPTADMWDTERADERSYEGWRTLDTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3E8</accession>
    <name>A0ABM0K3E8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101845269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107851.1">
        <property type="nucleotide sequence ID" value="XM_005107794.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845269"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005107851.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24634" checksum="75F8114752A9334F" modified="2025-10-08" version="1">MGNFLFKKADPMRILIQGLDAAGKTSILYRLKIGEVVTTIPTIGFNVETVSVKGVDITCWDVGGRDKIRPLYRHYYANTTGFVFVVDSADHERLDFAFDEFIRFCLQEEETKGTVVMVLANKQDLPEALTCEELEKKFRKKCPTTPDHKVLFRPTSVMSGEGLFEAFEDFVSEIKANREDPCASKAKEEQKSIEGKQGTSLKLFIKSPLSFVKSLLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3L9</accession>
    <name>A0ABM0K3L9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101854440</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005107974.1">
        <property type="nucleotide sequence ID" value="XM_005107917.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854440"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005107974.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25430" checksum="EF00F7FEB5861F9B" modified="2025-10-08" version="1">MAGTPRVTCWSISGAILIAFSTVFVIFASAFPYWQERELTREAGFPHVGLWEICFREDGEPAPPWANDALTKRYYGCNYVFDRELRTILHWIYPGWFIGVTFLVTLGLLLQPVAFIIDILFFVRVCSAHLEHVLVGVAFLLTTINGFTTAIAIIIFGIKSDTDQYWIPDPKSSHLSYSFAVCAFVPVLSWLAGMCHGVEFLRLKSIRDRNARAKVYARGEFGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4Z3</accession>
    <name>A0ABM0K4Z3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101849004</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101849004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP1R35 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108887.1">
        <property type="nucleotide sequence ID" value="XM_005108830.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849004"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033590">
        <property type="entry name" value="PPP1R35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029135">
        <property type="entry name" value="PPP1R35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28625">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28625:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15503">
        <property type="entry name" value="PPP1R35_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein phosphatase 1 regulatory subunit 35 C-terminal" evidence="6">
        <location>
            <begin position="467"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005108887.1"/>
        </source>
    </evidence>
    <sequence length="620" mass="68549" checksum="98041F883A019C39" modified="2025-10-08" version="1">MRTSTSAPFYNGGVNKSLRSQRLNVLADSMMPSPTVQGAVSEYEHLSYKYSRFGPERDSIWNEDEKGDFIPLKPPKHSLQSSSSSVPSMTTDRNFNNPNTNLASSSLKSYIPADDETLSAKGVPSPLAWSPGMLAGPSIFLTPEKSLGQDWSSKSSKENILEPHDTNQIPVPMAWSPGMNVKLNPSLFVTPEKPLPKYLSVVKDNFALDSAEIKENLEDQTSDLKTKGKHSVRFDLPSASSGDETSDSVDFANMKSPITLKGRELSSSSNFESPSSGSPQWKPLSPPKSYDPNAYSDESVLEDSLALHGPQTYKSSEMSLPSLLTFASTSKTASLTISPSDGDSGISIEPGTLQKEGKSLSNRKTNRKTIIKTKPSADSCTRKSIINSQSDLPGNFVVLDNLKTRKKKKQAGPQFLKSALSQYDKNPPKPFIIRESKNKHVEAEYSYPFDGGKDVGDSEFEHAFARPEFNSTLRVRSELDDLCEQEVDVQAAVLDTLAKSELKRTEMNEKASLYTNHSSDQFHNLVDLDTSVETLCERIVRMRTSKATGKKKASLYGKKPIQSDRAPDLMEFFSPELQRETPDLSLPGVSYVTSKLLTSPHDIAFDLYRHNRLWNGINDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5B6</accession>
    <name>A0ABM0K5B6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMP reductase</fullName>
            <shortName evidence="8">GMPR</shortName>
            <ecNumber evidence="8">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="8">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101863380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 8 9">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 9">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005109108.1">
        <property type="nucleotide sequence ID" value="XM_005109051.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863380"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003470">
        <property type="entry name" value="PRK05096.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="1 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="314"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005109108.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38146" checksum="714DA010C585C333" modified="2025-10-08" version="1">MPHIDNDIKLDFKDVLVRPKRSTLRSRSDVDLTRSFIFRNSKQTYTGIPVIAANMDTVGTFEMAKQLAKHLMFTTIHKHYSVDDWKEFAKENKSTLEHVAASSGISSGDLEKLSAILEAVPEIKYICVDVANGYSEHFVQFVRDVRKKYPSHTIMAGNVVTGEMVEELLLSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVIECADAAHGLDGHIISDGGCTCPGDVAKAFGAGADYVMLGGMLAGHSESGGETIEKNGKKFKIFYGMSSATAMKKHAGGVAEYRASEGKTVTIPYRGDVEHTIQDILGGVRSTCTYVGASKLKELSRRTTFIRVTQQLNEVFTPNTTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6C2</accession>
    <name>A0ABM0K6C2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multiple epidermal growth factor-like domains protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109765.1">
        <property type="nucleotide sequence ID" value="XM_005109708.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855058"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046612203" evidence="2">
        <location>
            <begin position="24"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="32"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109765.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="60354" checksum="508C72C067BD559F" modified="2025-10-08" version="1">MRILSQTLTVLLVATMVSVCVRAIPCDSPGTTRDKCHHFYGFPRVQGQYSDILATCRKYGGKLAMLETEEKSSAFDTLFSSKTIMKEGSLVFLGAKVWDNWRTFRWEEGPALTHTFSPWQTDEPSTQPGKDCVLTRRPRKWLAATCSVHPAMKLLAACQFCMTHAECSELCLCPDLGTANCTTALGCPARCLRVKKVDSCDYSPCPDKRWGPMCELQCNCAGPPCPIDTGICPGGCDPGWRGASCNQTACPLGMYGAHCDKPCFCRAGQQCNASNGDCLLGCFPGAGGNDCTLSPCDPGRYGPTCESYCNCYNSTTACAQVGGECLSREGCADGWVGPSCRLTRCNTGRFGPGCESYCVCHLGEQCDVNTGVCPGGKCRGGWERESCNVSNCHVGTFGKYCRKVSSLVKVNSLVKVSNLVKVSSLVKVSSLVKVSSLVKVGSLVKVGSLVKVSSLVKVSSLVKVSSLVKVSSLVKVSSLVKTHLPRATSSAAPLTRHIYHEPQVQRLHSPDTFTTSHKFSGSTHQVHHDSENFSTLKHFTFAPRQRVNPHSLIHNNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7V9</accession>
    <name>A0ABM0K7V9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein cornichon homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101846697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110882.1">
        <property type="nucleotide sequence ID" value="XM_005110825.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846697"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110882.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16794" checksum="828BB117249E28AA" modified="2025-10-08" version="1">MAFTFAAFCYILALILTAVLIFFVIFHIIAFDELKTDYKNPIDQCNSLNPLVIPEYAIHIFFTFLFLLAFQLGTVLFNMPLIIYHIRRYMNRPVMSGMGLYDPTSIMNADELGRAQKEGWVKLGFYLISFFYYLYSMIYVLVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8Q0</accession>
    <name>A0ABM0K8Q0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gastrula zinc finger protein XlCGF26.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111489.1">
        <property type="nucleotide sequence ID" value="XM_005111432.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854541"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005111489.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="58141" checksum="13180E704CDB5B80" modified="2025-10-08" version="1">MSEEGPAASTLTLLQIKLEPEWNSALEDVNMGASSHLNTPAVENNSNLQAVEESSSQGSISQNCEEGMADMSSDDERIIKLEPPDSDDEESTDELLKTTVEATSAIERKSNGDFIRIIGDRKSCAKQIECDECGKMLSGRDSYRQHKAIHKGERPYGCGVCSKTFITKKQITKHMRTHSGERPYTCTECGYSFSDRSCCVRHMRRAHCREAGKFLCSQCLKIFHSEQEIIKHRAEHEFQKRNKRFDCQYCTKYFKQRSQLMAHEKIHTQVKEFNCSVCFKAFLTKDRLVKHSRTHLLDKPFQCGECSKGFSTKRGLLDHMAHHSGEKPFSCTVCNRGFIRKSHLENHMSVHSETKPFKCDRCFKCFAQQTYLITHSKVHESCKHFHCSMCSKRFRTNSALKLHQTMHNETWEYSCDDCGRKFANLKYLNRHRVRHDESKGYKCLDCGKTKWSKAELMEHMRAHTGERPFQCPVCGNCFAYAWSRKMHIKKFHSDVKTEPKEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8X3</accession>
    <name>A0ABM0K8X3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA processing protein 1 homolog A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101852891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111644.3">
        <property type="nucleotide sequence ID" value="XM_005111587.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852891"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="759"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005111644.3"/>
        </source>
    </evidence>
    <sequence length="851" mass="91803" checksum="24E40911C609D339" modified="2025-10-08" version="1">MLPFPTIINIVEKMEGSAEVHFAQKLASNEKKIRDRAMKRLQKYLSLKSSHGVGLSDDDFLKIWKGLFYCMWMQDKPLIQEELSKRITGLLGSFPNIEDALRFVKIFLATHAREWNGIDKLRLDKFLMMIRDMLHRTFCLLSQAGWPVPACLSFSRSLSETVMQPEESRLPDGLRLHIADIFVEELRKVSLSEMTTPKLVTLLQPFIVYIVFSRKAELVQRVMSCVICEAISTLRPSEEGDKDGEVKTADPSSQEEQDMEVDTAEQKEDEDVTFQLDVSLLLQWMFRLAQKNEVKAKNRAAVYNLVKQHPEVLLKVNSSEQGEDDDFSHIFPDFGQAFGASALTSPGAGGEQKKRKRRRKRKKQSSGVVEDGAGGEVPEGEVSAEVPKAETEENVKGPHKKKKGGKDLSGVSQANVGGLGAQTEGKKKHKNGLQVSDGGDSAKSDSVVVVTPSVQKKKKRKLSSDGEVKGVSAGGDSPSGNSDPFLGQKLKKRKLSSNAGADNIKKSEESSGTTDVISSDGSLGVKKKVKGKKSPKKVTAEESVSVESSSSSLSNTNTNARPKGSRLKVEAVELVHYPQAPTTPLSAGQSGRGLTSPVKVESLHSKSPSDIISASNVVGDGMSRLESSVSSSSSATSPTSPSRNAQEKSPPSTPNAKLSKPKKDTSGSKEDMETSPGLSRSSATSSWTVVETALATPCALVKKAVAMVAPASDPGPAVEHKLMSDPPGLAMTPGAKKKVVFDLRKNKANKFQDYLKSLATQGAPPYEPSKSPSQSILKPLSASPAPSEDGSLEVSSDLGLPGGGKKSRAQRRDSVPAGQRSANKKGKKQTAAYRSRSPSPAVTRRKARAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8Y3</accession>
    <name>A0ABM0K8Y3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101858534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005111668.1">
        <property type="nucleotide sequence ID" value="XM_005111611.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858534"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044965885" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="155"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005111668.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="60698" checksum="9FA426E0D77F38BD" modified="2025-10-08" version="1">MDFLFPVREMLVQAALLMLVLSPRYCHEQEQGMSNSLSSQLINEFKNEYHPQHIHISFGAFPTDVVIMWSTKEDVRGYVEYMVEPNDLKRALGIKVNASEHGEHALKFIHRAELQDLMPDTTYTYRVVSEGTESGSASEELKFKVPHNDPKGKHTFMVVADMGLRANKQLHFVCQEVVNGEYEAVFHIGDIAYNLHTSSGIVGDQFMEHVEIFATKVPYMTTPGDHEKELQGPSPYYEYRYRFSMPNAPWPMRVDSLWYSLDIGQTHFVSINTETFLYSSPLRDTQFMWLKEDLIKANKNRKSVPWLIVMGHQPLYCSQSVMEVDCAKENSVLRGLLEDLFYEQGVDLYLSGHKHSYERTLPMYGGRAFQTDYVNPMAPVYIVNGAMGYEYMVDEIRSKHFWLPFAQTDGKKELFARLNVLDGTRLIWSARAAESNEEVDTIQIVQRNHSSFGNAGPDAFRKIEYLQKSNQNKLNNLPPEPFIIIDSPPSTATQYRTFILYVVVFALALILFMFLRNPRMRRILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA48</accession>
    <name>A0ABM0KA48_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein kinase Aurora-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112602.1">
        <property type="nucleotide sequence ID" value="XM_005112545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862989"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112602.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40715" checksum="13875AD8CE8B41F3" modified="2025-10-08" version="1">MPVLKEAKYRVLNKDALEILDMEQMELLADRGNWEVIVAARVRQPKVKRVLKKFLLFEDDDDTSRMWKRSSFEHELSFLQSLEHHNIVRVLAAFQCPSYLGFAMGYHPTDLSHGLLDVTYSEAESYTSQLTDVMCYLHGQRIIHGDLKLGNVLLDRAGRVKLCDFGHSQVIPEDSDKPDGWGGTDGYKPPELYHSQVHNAFKMDNYSLGILLWALFFGTAPRNNIDYLKEVDNCSFLKPQHKHCLQRLLSLSPTHRAYIWEIARILKDEDTSERYVSKGSVCSLSSESSSESAQANQSSPDSGSSVTERPESAAVSIQFLAIPPPHPHATSCYLLPQTAYPESGDVPTSLAPTWPPLHQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUR5</accession>
    <name>A0ABM0ZUR5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934866.2">
        <property type="nucleotide sequence ID" value="XM_013079412.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854070"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="177"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012934866.2"/>
        </source>
    </evidence>
    <sequence length="400" mass="43930" checksum="4811A9D2DBFF1BBE" modified="2025-10-08" version="1">MEALFETACRKIDEEAEELRSLSHLIWSNPELNFEEKDSHNVITDFLEKRGFRVQRNYVLETAFSAEWVNCGKLSWELPHIMVLCEYDALPEIGHACGHNLITELGVAAGMGVKAAMEENQGLVGKLTILGTPAEEGGGGKAYLIEAGAFKGVHAALMAHPAPFNIDDPTTLAVKFVEVTYHGKAAHSSVSPWQGINALDAAVHAYTGISHLRQQIRPSGRVHGIITKGGTKSNIVPDLCKMEYTIREDTLANLDLLCDKVVGCLQAAALATGCTVEVEWEAKPYADMRNNETLVSVYQRHIERLEPGRQAHKGEKEAFKGSTDMGNVSHEVPSIHPFYYVGNELNHTNEFTALAGSEGAQLFTLNQGKAMSMTCIEMMMDKTLLQRAASDFQSTKARQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUY4</accession>
    <name>A0ABM0ZUY4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934974.1">
        <property type="nucleotide sequence ID" value="XM_013079520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011105"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047515360" evidence="1">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012934974.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17053" checksum="1BDBF1EB2DA0FB6C" modified="2025-10-08" version="1">MMIGLSSILIVACVCLTAMADSPPECTERLNSVAKLKDLYCDAHVVFTGTPLSAMSGVSTTPEGGQIETSLTDFSVKGVYKGEEEYNVQVMRSYHNQEDQCSAEAFPAPRGVSEIFLVFGTGASGRYDVQACGHRFLWSCVSKKVQKALRRRIRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV37</accession>
    <name>A0ABM0ZV37_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101852673</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935074.1">
        <property type="nucleotide sequence ID" value="XM_013079620.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852673"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045782181" evidence="1">
        <location>
            <begin position="29"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935074.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="48771" checksum="89282FCF2C111EEA" modified="2025-10-08" version="1">MLHTALGRRSLLLFFLCVVLALLECLRGEVFSSVSKVRALIQHEAQLLKHLERVVEISEKLQEEPDRLLNLRRSLKCLKERHDSHKAVPCLGENPVFAFSYIRRLVRDWALVTSTGNKSSDNSVLTDNLRRMREAISRWHRWPTEADVYGAGLSLLRLSSIYKLFPHSHPPKRVQEEACPHHAISDYFQSLPNRQYNLINYDWNFSSPLLYHSELKGLSRFGWLRKLPLGVCGAKHNNNPTIERRDNKCKPSNNWLEVDDFVAVAQSAVNNSLHKEALSWISLAQKSWEVGSGSDLFEQSSSIKDLRRKVEQALNKQKDDSQSHLFKEYERLCRESLSQKQTPVTYSGGPTLTCTWRHVWPWVRYKMELMHVTPPIYRFYDVISDSEIRHLIHLSEDRLLPSQLPDYKSTRNRKSHVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVG9</accession>
    <name>A0ABM0ZVG9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">thioredoxin-disulfide reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101848733</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012935347.1">
        <property type="nucleotide sequence ID" value="XM_013079893.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848733"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006338">
        <property type="entry name" value="Thioredoxin/glutathione_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01438">
        <property type="entry name" value="TGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF8">
        <property type="entry name" value="THIOREDOXIN-DISULFIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 14" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="16">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="213"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="570"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012935347.1"/>
        </source>
    </evidence>
    <sequence length="697" mass="75305" checksum="A2E91FCE44333160" modified="2025-10-08" version="1">MVIGNQIRLLRRHLLLQISVLDAVGPSSRKVSFGRPAPTNTGSSSPTRTSSQNPRALSTAAAAVSPHKPKLSLGSGLSYLSGGAQAGPSKSPRKFHSTSAMPPIGDDVKPEVQQLIASNAVVVFSKTTCPFCTKAKDLLKSLSVKFEAVEVDKTEKGPKYQTALLELSGQKTVPNIFIHGQHIGGCDDLMSAHCSGQLTEMIQNKAALVKYDYDLAVIGGGSGGLAAAKEAAALGKKVTLFDFVKPSPPGTTWGLGGTCVNVGCIPKKLMHRASILGEDLHDAREFGWEVPEKVNHNWQKMREAVQDHIGSMNWGYRVQLRDKKVSYVNAYAQLVDPHTIKATKKNKQEVTVTFDKAIIATGERPRYPDIPGAKEYCITSDDLFSLPYCPGKTLCVGASYVSLECAGFLAGVGLDTTVMVRSILLRGFDQQCAEMIGSYMSKHNVKFVRGAVPTKIEQIEEGSPGRYRVTARTTDGQEIVEEYNTILLAIGRDPCTKGIGLENAGVQLHDKTQRVLVDETEATNVPSVYAIGDIGEGRPELTPVAIQAGKLLSQRLFKNANGSLVDYRNIATTVFTPLEYGCIGYSEEAAIEQFGEENIEVYHSYFMPLEWTVPHKEENTCYAKLICNIADNERVIGFHVLGPNAGEITQGYAVAMRKGATKEDFDATIGIHPTCSETLTTLSVTKRSGASAEVTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXQ6</accession>
    <name>A0ABM0ZXQ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Formin-like protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936653.1">
        <property type="nucleotide sequence ID" value="XM_013081199.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863426"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047356764" evidence="3">
        <location>
            <begin position="26"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012936653.1"/>
        </source>
    </evidence>
    <sequence length="768" mass="84500" checksum="9AAECFEC2E484939" modified="2025-10-08" version="1">MDKNTRTFWTFLVVCLLSCIPGVSADETRTALIAAGIVVGVLLIIAIVIGALYCSRQLNRNEEKTLPKGYPNGTLSNGVYRGDDPRMVYSPHEDGRNNSASPRAKSYTQHAAAPRQRPPVVFYTIRADPRVPQVPPDAIPIAPPHPYRGPPPVGRPVMFLDFFNGGSRMPNGQPGQLMYPNGGTMLYYANGGPMIQEVESSGSKSSHRHRKSERKHKSRSKSRSRSRDPHDKRHSSRRQTHSDPEDLTVRPFEGDVILTTRQDDDIKKYSRATERRSTRRSDDNNNNPLQLYFDNGGLDLGPQDDFNNANSNDNNNNNDDNIDKVYSEVVGDGFVRAEQKFVSEGGRYSVTQVQTSSVEFGSPPTSTINHTILQEKEQTIGFDDEDGDSIPDPTPRIDYSRQTSEVGGFSYPEPSRVVISDGLSRSISPSPLHYMGSAEPTPRPDYLTGDTQFPATTEPVDGGIDDIIALGNVTVETTEVKEVVEEQEFISHHRQDPTLDRPPTPPFDGGESPRDSVYPPRGDPIVHHAHAEIVTSSFSDVTARIPTPPPDMTMEEILPNQDDAERRLSQLVGRPSPPPSPPLDNFGGRTASWRPPTPPPGRIIPNPDINIDDILKLGNQPLSTPQPSEPFAESNKRSPHGSQGRESGLPFMAELRKRQQSIDDGDLPFAASEPAPPQPSTSRGVGLDSDPNYIYRRVIVNEDRKDSYGYRQSTVQFAQAPPEIIPFGEDPDSPTTPRDYSGGPAFSAASPPPPPPPPPPPLPPNMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ45</accession>
    <name>A0ABM0ZZ45_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Macrophage mannose receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937504.2">
        <property type="nucleotide sequence ID" value="XM_013082050.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856422"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="66"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937504.2"/>
        </source>
    </evidence>
    <sequence length="242" mass="27642" checksum="6ACBFFDE8BBD3230" modified="2025-10-08" version="1">MTNQPNDAYGSERCVRIGSGSLWGDQHCQDKRGYVCKKRPGDYTVPPMTPASTKGGCPLGFHSLPSLSKCFTIGGLKPSQRVNYTDAMSVCNLLNYKSRLASIHNPVEQKFITVLLANSGSRSPSWIGFNDRRFEDQFVWVDNSRVDYTAWGYKQPDENKNDKRWIARRDCVDMDMGVQNSGRWNDRRCSNKYSFVCETAKGEEKTQTISTHPYSHIYTCTHIYANTLMQTNLINFVQEVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ56</accession>
    <name>A0ABM0ZZ56_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106011661</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106011661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937519.1">
        <property type="nucleotide sequence ID" value="XM_013082065.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011661"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045081007" evidence="2">
        <location>
            <begin position="27"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012937519.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24057" checksum="ECCD47CFD59EE535" modified="2025-10-08" version="1">MAGRKLQTAVLQLFLLVGIQFLAVHGYVSITEELRNVVLGEGERAKFVCKVDVHHLDEKRLQVIWKANGQFLKPEESGRMVFKNEGTRFALIVRNVKTKDTGIYTCIAKVGLETAMSSAHLQIKSKSRLISFTVSKIDSFVFYSIVGFLSALHIKCTKTSRLYIAFSSPYFQIACKSFFRGFIFFYSLCVLFFLVGSLYTRMCIFLMIRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZE6</accession>
    <name>A0ABM0ZZE6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calmodulin, striated muscle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106011701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the troponin C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937682.1">
        <property type="nucleotide sequence ID" value="XM_013082228.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011701"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF46">
        <property type="entry name" value="TROPONIN C-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012937682.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16228" checksum="F0A1BEE903FDB77D" modified="2025-10-08" version="1">MSEEYKAKCKSFFDEADADGTGCVSRLELCKVAQRCGCNNTVDEISDWFDQIDKNDDDKLTFDEYWSALNKRDPADVTESQLRATFQDFDSDNSGYIGLEEVRTILEGAGEDPSLADQVLDAVDTNDDGKINAEEFLRAWKQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0K5</accession>
    <name>A0ABM1A0K5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938392.1">
        <property type="nucleotide sequence ID" value="XM_013082938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011855"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="63"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012938392.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41657" checksum="0FF9CD81495A15B2" modified="2025-10-08" version="1">MRGEMLSRIHDGHLVVSKCRERAKSSIWWPGLSSEIREVVSRCDHCQRKRPAQPSEPLAPTALSERPFQMVGADLCNYKGHDYLVLVDYFSRYLEVAYMPDTTSETVVYKLKNIFAWFGIPELLVTDNGPQFVSDRFHKFAKGWGFKHTTSSPHFPQSNGGSERAVEEAKKALSQDDPFLALLIYRSTPVSPTGASPAELALGRRLRTTLPILPSNLNQQVYDRAKIAARDAESKHKYKQAFDRRHGAQNLPELNPGQLVLQKLENDKEWRGPAVVKERCAPRSYIIQSGDRAYRRNRKHLKPYVDPPSMPSSPVATPEPTPMSVPLPPPPAAQPVEPDVTPPSPQPAAAPASPAPITTRSGRVVRRPARNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1L3</accession>
    <name>A0ABM1A1L3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012005</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938982.1">
        <property type="nucleotide sequence ID" value="XM_013083528.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012005"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938982.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="24641" checksum="B04D123C59E97E6D" modified="2025-10-08" version="1">EDDDENDDCSDEKKNNNNTKDSNRDEQIDVVTESGDVTRSSSDRRGDNSSSKHHEPEVSHCRLSPELPRGPAYIASDHAHVDLDSGKPKIWSVTDFLSSAHHPAKDGPPGAFSKLDTLKSVSDLSPTGLTASDASRANALLGRSVGSSATSNGLSPLSSPAHHLSAYQSTLGYGVGAYPYALSSYGGAKLLRPSMSAAAAVSRFSPFPSVRPMGMDSPYIPRRDIGLTREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2J7</accession>
    <name>A0ABM1A2J7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012138</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939560.1">
        <property type="nucleotide sequence ID" value="XM_013084106.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012138"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939560.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29024" checksum="C439B10C88221ECF" modified="2025-10-08" version="1">MVKEKTEPKPKMARVVGFKDTMGRLGTVVVMLITTINMTILTVRYYSENHYWEAVVHTGLLVLLHIPVIFILSLGVISAAVQKTRKFVVARRKKKKVGDVEKGESASVEEEETLEIVLVEEVAEDTLKGGEVNKDDQLILSDELLEAPLDTSCAEASSLTECRSEENTDKGNTHSEESTDWCGPAEEKTVENLCLVKKEGQKETKSIKESDLVLVTELVEESKSTLGNLGKRSVKQIALGDKGESDLDKSDSFRLDNLTKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2V2</accession>
    <name>A0ABM1A2V2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101861739</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939714.1">
        <property type="nucleotide sequence ID" value="XM_013084260.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861739"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047472394" evidence="1">
        <location>
            <begin position="30"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939714.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="69227" checksum="6B2BA24CD5EF385A" modified="2025-10-08" version="1">MVPGFVMYTMTLCVLSLVLIFALICNIDAHVRFVCPKPATSKSDVEFNRAFPITDTSSDGSVADDATRAAAAVFDDSLSVSGEDLCGVSGGLDNAPVTDVRPGMLTVQFEETKFLTDAPFRLALLQRSSVTEQHDNDTDVLSTWQSCLLLDHIPHNAHAVVSQKCAENANSELAGTCTESSYHLTIKVPDVDCEDCILLLQQVRVPTGGQVCELNAQHNNSLQCSVYHSCARVSLRATAFGQGRDLSYCSNYLDNLPGDWPYRPQDIYKTEDGATLRMDLVHTTLHLHVPQDSKLGQLERVEVRDNSTVLWNSTVDSGQRAPDAVSVTWTGLTGAQMDALRGGQLILNVVGAKESQAADILFSKQHFPTGSMSSLHDWYTLGGWLHAPVLRGVTDDHPELATTVDDPVVVAPVGPCGTSARFFMAILESVHMTAHGIVGLSIQGTRAYISAVLHVEREIVKSLVFKGPDLVDIPDLVLEVPDNFDGTLQVVRDISEQLPFLDSVGFLKSVEVNSDREHAVLEGDLEEGLFTELRDESGKVGGLGAFQHTQGKWLRAQLVVVDSAPQIQLAQMVGPQGVLLDFSRDTVHCSATACCIDTYVQELTSDMLLYQSVGWIHFLLSTQASNMTGLIIKEAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3N6</accession>
    <name>A0ABM1A3N6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864697</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940182.1">
        <property type="nucleotide sequence ID" value="XM_013084728.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864697"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="DYNEIN HEAVY CHAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="1">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940182.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13909" checksum="A9F63D9EE77DA604" modified="2025-10-08" version="1">MPTIPPPGDLRELKSLASPPKAVMQVFSALLALLGHKKSDAEDWKFAKKQLASVGDQKINSQMAKFDPKPLTPAKVKYVQEKIAALSAESVRKVSAAATSYYVWVKETVSSLPSELTAEQPTEQAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3Q6</accession>
    <name>A0ABM1A3Q6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette sub-family G member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940212.1">
        <property type="nucleotide sequence ID" value="XM_013084758.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858645"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF113">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="572"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="695"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="114"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012940212.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="79728" checksum="A56D4E4F2CD6020D" modified="2025-10-08" version="1">MDEDKEKLLPKGETSFTENLNQKLYGSFAVRIPDTIDEDVGSLRSREFSNSVSASASVGVSGALSTEAGSFSTAVGAPAFPQGRQNGGLPDLGDSGQESPFLATNEESFRPPALNVVGLSYEVKERPGQWWNGSCFRKPRKLQILRNLCMTFRSGELTALVGNSGSGKTSLLDIISGRAQGQVSGVVSYKHETCTRDVMKQRSSYVLQADRLLPTLTVRETLTYMAYLKLPGHWNADQIDEKVQSVILDMGLRDVADSRIGGAVIRGVSGGEKRRITIGVQLLKNPEILLLDEPTSGLDAFTARHLVSSLADLAHRGKLVLMSIHQPRSDIFGLLDKIAILTVGRVAFSGRPSQMVPYFSKIGYPCPREQNPCDVYIDVTSVDRRTPAREKETFAAAQKICNAFSNSDLQANIIKEITSGLNHHYNESLEFDGKSGTSSPSWGRIFRNLLIRMNVHLQRDRGSFIGRLAHLPFFVPFILIFVGRLGTNEGSIQDRLGVVYQAVQTPPYMGLLHAVAMFPPLRDVFYRECSDGLYSTTTFLSAYFFHVLPYNIGASALFSILIYWIVGLNEDVWVFFQFFIMCIILMQFGEIMAIAFLGIFRDSQLANNTTSLVLAASGLLASGLLRSIENMPDILQWAGYIAVHKYATEVIVVNEFKGLVFDCESSVPGEPCQTTGQDFIDQVYPGAENRLDRNWGLVCSYFVAILILAVMLFKARGIPILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3R6</accession>
    <name>A0ABM1A3R6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101863755</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940227.1">
        <property type="nucleotide sequence ID" value="XM_013084773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863755"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940227.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="64714" checksum="1CE08E0BFAFC587B" modified="2025-10-08" version="1">MQLILMAMPRGDPDRDSDGNNDHNYNNCSAGTAHSNNTQHQHRGDSSAQDFTLIDHASSNDNDTRSGFIINNNNIHNHSSNRNSGSSSRSDSRGRSSELPSQTTAPGHASTTCLVTPVGVSVVDADNLVLRSNPVLFHDGGRPSIYDQRSRPLLHPLYTTLGSSGGESSTQQTHGNETALTTATETYDAVFTRGGVLTLDPQGVAGGSDSLVVSCGVDTSGVNEIITQSASSRPAEAICSIVDENMNFFSRHPIDPTQVEISAPCHIDNDWRSTPAETVAVGQSFRQREAFLEGGSGHEVTMLSHHGHIRQQHSVLSHHITPSYPERTLLLPLDCESLIASRRALLSGEVNVVPLETNRLPIWTPLARRDNAPVVPTCLALLQPNASVSQSSTTATVASDPSVMFTPIREEQPDVKTSSTEESPSSEKFTDFVHHPRHHACDAALPRRKDSLVECHASMLEEYLSDGPDDGVELLYSQGARPLLDSPHFYNGLSSAYDDAGAHASSAAANSAEFSLPPQWRADSVQAQASVDEEVAMVTYGHVEEEEEMMTVEFDHDDVGLDADVSSRPANPVANILDSGGREHFVPVLTDVFHTASRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3V5</accession>
    <name>A0ABM1A3V5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101855351</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101855351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940294.1">
        <property type="nucleotide sequence ID" value="XM_013084840.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855351"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012940294.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40266" checksum="6E1F26618DA2CCE8" modified="2025-10-08" version="1">MANNSTTAIEIVTKSDTFVAAAVFVSNEASYYIEVTLDLVLVTILAFVGIGTNIIDIVVFGRQGFRDSVNISLSAIATMDLIKCVTGAAARMNGILGLFSTALAVTWKNICTPTLLYLQIFVGYVSYVMAAYVAVERCLCVSMPFKVKSLITPKLTFCMMVMITVVVMGSFSVVFFIYRIDWVYSDKYGQTIAIYGYSDFYDRHNFGVMWYYNLIGVINPILSFTVMVVCTVIIFYHLRKASKFRQQSQQGGQESGKGGSGDQGMSSRDRQVIKMLLVVIIIYIINFVPRISMYVAKLFVKEYYFLKRYHNIFMLSTYTLFVIDFLNASMNLFIYLTMSSNFRATFFSLFIARKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A420</accession>
    <name>A0ABM1A420_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012326</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940389.2">
        <property type="nucleotide sequence ID" value="XM_013084935.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012326"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="1">
        <location>
            <begin position="38"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940389.2"/>
        </source>
    </evidence>
    <sequence length="163" mass="18393" checksum="9B138F8561F2F2C3" modified="2025-10-08" version="1">MIGPSSAQAPRHVRQTGNVTGLKLYQGVPVDTPCAWAEFTVVYRGFYPLAEDGRVDRIHDSIENVITDSGRRKEVVKIETTETGVEVRRLSDNELLLNHSYTEVSACGRRTDMLLYFGYIAGETTCNMAKDFKCYVFESEEASEAKIILCSIAQGFERTHWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A474</accession>
    <name>A0ABM1A474_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein DDB_G0271670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940494.1">
        <property type="nucleotide sequence ID" value="XM_013085040.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847827"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045789532" evidence="2">
        <location>
            <begin position="25"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940494.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="58827" checksum="E336FFE6C1123EE2" modified="2025-10-08" version="1">MYSLNALVAIVTIPLLTLQQQAEGMVLPTSAGSRTDDVIVHSSPRTKDGPPYPASAITSHTGAPAYRRGTGDPHNTRVEKTLTFASTNHRGDGDSSDPPPSGVGGASNSSPPPSSMGGASNSNPPPSSMGGASNSSPPPSNVGGASNSNLPPSSNGGASNSSPPPSNVGGASNSNPPTSSVSGALNANPPTSGVGGASRSQATPPPRLSPLLWRSSPRVAPPLRQVPRAPSVLTFTVPGAVEGVAAAADDDTADDTADDTDNDTDETSAASNSASVPSSSYPSLSSSSLSLSVSSLSPHQSQTPRLSSTFVKESLVSSPPPESSSLFSLSQTSQPDAATRSQRSPREPRSTTATPSSPTTQSAPATTTTTTATASSSSLEQSTSSTSANLTTSQPTHLSSTFPPSRPPIKALTRVKRQSSSLQTSQTLAPSTAPTPSPRTTTSSSATSATSSATPPTTSAAATSAATSSAATSSPISSSATSSPTSSATSSSPSPSRTSADDSSNPVPTYLSHPASTPQPVPTAKSSPTHPRASANQDQAMTSSVTTTTTTAATAACPEPRALFTFACHRLGGSSVMAAVASRSGTFYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A481</accession>
    <name>A0ABM1A481_APLCA</name>
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        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101851058</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101851058</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102827.1">
        <property type="nucleotide sequence ID" value="XM_005102770.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012940514.1">
        <property type="nucleotide sequence ID" value="XM_013085060.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851058"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940514.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36384" checksum="F708FE24E5E47707" modified="2025-10-08" version="1">MAGNFSNGTDRHAWLDAVDWRAMEIIGFFFYGIYIALGTFLNLGFLAAILTSSEMRSTFRNKMVCGILLGNLSDSAIVMPLYIIVHVLHPLMGRSACILWDMSNLLAYVQDFVGNWSVCIAIASLVACTYEWDPSLKMSPLAFKIGRIALLLFPWLLPSIYIPAVSYGSVKDNRYYCISHSLRGNVFFKVVDSVVPLVSSAILLCLIAIARRRRGLAGGVMKTELIGEGSPQQDSVRPYVGVVAIAMVCDSLFTLLILVYRQITDIRASIILGFVSHLLRDARVVAIPSGLLLFPDIKDRVQHWRPWRKQAAGIDLTINYTRSQDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4S9</accession>
    <name>A0ABM1A4S9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Density-regulated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101849709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940837.1">
        <property type="nucleotide sequence ID" value="XM_013085383.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849709"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="110"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012940837.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21496" checksum="7DB9D4A8DE724D0D" modified="2025-10-08" version="1">MAEVAPPKAFLEYSGPVKGVKYPLQVLYCGDCGVPVEYCENYPNYEKCKAWLEKNMPSEFEKLKVDKGEGEEGSAESSKDLAEGEEKKKRQTRGGKAMMKTKKKVEPQGIKMWTQTRGKKKKVTIVVGLASYEIDLKDASKFFAGRFSCGSSVSGDDEIVIQGDVKDDLFDILPEKWKIIDEDDIDDCGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4V6</accession>
    <name>A0ABM1A4V6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trithorax group protein osa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940878.1">
        <property type="nucleotide sequence ID" value="XM_013085424.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012438"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1029"/>
        </location>
    </feature>
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        <location>
            <begin position="1039"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940878.1"/>
        </source>
    </evidence>
    <sequence length="1413" mass="152318" checksum="2678DEF7750BC159" modified="2025-10-08" version="1">MSSWCPQVLRSRCRVSEDKVEAMRLSLQRRYQAQNRPQTSQGTASLPPPTHRRESYAPPPRPVSPSRGMSSPPAAGYIGSNMPQNYNAANLGHAPQAQRGPALPSPQQARAPSGYPNGQQNGFQSRQQIRHPSYRPPPPTRYSAGTPYTQSGPSHTHPSLIRPSQSQTPPGSFQQTPPIPSYPANRGLNRAPPMRYQNLNFRSQTRPGASMNQGRQQPPTGRRTPTLKNGEFPFGIDPFSSGPPVDVPVIQQAYSDRVLAPKTPAPAGAPSKKTSDPPQSLAFKKLKFTLSRLKDVIHGDSEPAKSPEIAKTKPPTSQQRQTQIKQVEQPRKPAPQSTASSSAAQSSESSAAAIKDALSGFLGRVSQGTASGQDGQSGQGGSARGGFMAFIVQPTTTAMPTSSERPTFHPASPEQPPLSIDSAPYATLDLGPLNLGLSEMMQNQVPGGLMEQTDQSINTPAGLSRDPGSTTSNLVPTNTNSNPLSTGSSPQGNQNSPSNSPNQASSAPANSAQPQSAVVRTAQNSFANQLIPGPSPPNPQAPQQSAVPTGPKSPHPVTHNQPAGDSQVPVQKTVAITTTQEVNNKEPSSDIQKLQMFHPGDQGGRNNFQNEAQTKDFSSLGGSDKNVIKPSPGIASPSGQLGAQGSQNIQPQPQPQPQPQPQPQAQAPFVHTHVPKDQPQSPPAGVNGQNSQTQPHTGRTVVPNTQYFSGGNLNNQQQQQQQQQQRQQPPPPMTPSLQTFRPPPPYPNPSLGNTNAHNNQSPPHGHSAQTFVPTAHVQPIPGTMNNENSQPPVPPAAKRQTFSPMPQTSNTQMAAQPSRSFDTFPATATATEQSVPGNPGDPQPSFSGAAAIHPKQAQAVHQLDVGTMSDQPKLLDEIVNEGVPRVTSNPKNRTGVTSDFPSPLQSSPVRSTNPGNFQTQQQTEAPRESSIPNPNSRVNPMSPVQPATTQGDFKGFIQIYKGPGEYVLIPLSPSSLLQVLQNEAKKATYPTQVTQNVNTPVHPSFVTSQPGQTSPPNAPAGQQEQAQEVGQGGQPGKGQWSQPESPQQGISSLPPSPQFHNSQPAVSSSGQYQQPPYKQMWQPTQTQTRQPTQHPPAPSRQDQLVTTAQGSHQTSQNVPTQHSQEPRENQPNFPQLFTQNPQQQLPVQASSQHQQQTPQPGQQQNAQQRHSEQEYVHQPQKQEQQQQYDINPMSPQTGPVYNQQTPPRQHSPHPSQGSMTPVQQQHQQWNPLPPAGVQPLQQQQIGQMWPSTQQQSPPQQQLWQLQQQQQQQQQQQHQTGENPPPQGSVQGQGNAVGFQSLPQPSMTPQDLVRLTQTVPRWSTTSAAHPHTDPTRPQPRVTQQPPQNHAHSVAAANNPQSLAYVTQWQASTSHTYTPAPPSPQSFAQSLLDESPNKETAAHDSFAQQVPQDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A535</accession>
    <name>A0ABM1A535_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein K02A2.6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940989.1">
        <property type="nucleotide sequence ID" value="XM_013085535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012475"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940989.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29721" checksum="C89707FE7632AEF8" modified="2025-10-08" version="1">MPFSSYKMKEFATSWNFEIKTSSPRYPQSNGQSERFVNIVKTMFRKCTEEGSDPNLALLGYRNTPITGLPYSPAQLLMGRKLNDLVPTDPKMLKPQLPVDAPYLLQQRKIEQKKHYDRHTKSRPDHHVGDSVRVHTGRSNNWEKGVVTSMSQAPRSYYVTTEDGTTWRRNSRVINKSKHTPVINEPSSFDEDEHQSEQQPQGRQTNNQSTTSQVEFPNSQPRVELPCASYNNTTHYNRPAYTIRCGREVKMPKRYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5G2</accession>
    <name>A0ABM1A5G2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862598</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941196.1">
        <property type="nucleotide sequence ID" value="XM_013085742.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862598"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941196.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16320" checksum="B559DBF7D650D38C" modified="2025-10-08" version="1">MTKEKERTVGRGRKKEKKKEEEEEKRMMRGQRNNNSYLIDGCGQLCSNCPPMTGDQAEQLLCYGAVGKDPLLRARVEQALLEVTADKVIKNYLTSVRYGLRDVMDQLLEAIRGKFSVVCQTQEFLTLPLGIVKQPENDWILTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A633</accession>
    <name>A0ABM1A633_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein argonaute-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941544.1">
        <property type="nucleotide sequence ID" value="XM_013086090.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863122"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045077714" evidence="2">
        <location>
            <begin position="20"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941544.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="63331" checksum="D0F62287D47B488C" modified="2025-10-08" version="1">MTSQLAVLASIFLTSLALGHPPPAPWPRSPITPATQWLHSPQHAFMPDSYTATLRDTRQPPLTPAKLNEILKFLSLQQPSHPQPQMVELLTRLATAPGSNPSSATSSYFSHTSGGSHSSQGQGQGQGQGHGQGHGQGQGQGQGQSLSYVETLLQSIYEQYQQQQQQQQQQQQQQQQQQQQQQNSSGQQQHNGHSHGYQQHGSQQQQQNSSGYTQQQGNGYTQQQENGYIQQQGNGYTQQQENGYTQQQGNGYTQQQGNGYTQQQGNGYTQQQGNGYTQQQGNGYTQQQENGYTQQQGNGYTQQQENGYTQQNSGYTQQQGNGYTQQQGNGYTPQQENGYTPQQENGYTQQQENGYTQQQENGYTQLQGNGYTQQQENGYTQQQGNGYTQQQENGYTQQGSGYQQQQNSYQQHSGSSEEQGESGVREEQMAGYLEEQEEEHGHLEGQKEEEEEVRGGGYYGGYEESEESDESDDVAHSKDDRDDDSYDDDSDDSSESKDDDRKGAVCPMFQPHPTDPQLYLQYNGHRWAPRLCPYGFAYDPNTCVCSVRLFGPTTTTSAPAPVTTTPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6H4</accession>
    <name>A0ABM1A6H4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neutral cholesterol ester hydrolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101864246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941750.1">
        <property type="nucleotide sequence ID" value="XM_013086296.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864246"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="130"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="302"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012941750.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48194" checksum="C1847F928AF7CA37" modified="2025-10-08" version="1">MGSLKSKLKALVMVAGVVVALLAVVYRVYLVMHRAVPADLAEVEKIRWLDEMGRIARYGSQLLQYFGIEPGIEPLKLFINTAFSILVSPLPWQRVRYRDVRVSQDVYAGVPVSTYTPVHPQSDTDGYPTIIYFHGGGWTWLSVGVYDGPLKHLANYTKFKVIAVEYRKSPQHPFPAAYEDSLAVTRYVINNARDLNICKDLIVVAGDGAGGNLAAAVANEMASLIRLQVLINPALQMLNFATPSYQEHVDNAIPGITSTEKTVSSWMRYAHVHADVKPAMLDNLHVSLRHYSFLSNFVDSRRRLPAYLNVTDKHTIHNSACREEVSSVLDQYVLDSRFNPMFAPDVRNVADAYIITAQYDVLRDEGLMYGHRLQENGVDVELQHYKNGFHGFFLFAGGGWIEFAESQRAMEDLVSYLHTEVLDLPLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6N6</accession>
    <name>A0ABM1A6N6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Persulfide dioxygenase ETHE1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941863.1">
        <property type="nucleotide sequence ID" value="XM_013086409.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849313"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="112"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012941863.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="36931" checksum="AE3A255DF26D949F" modified="2025-10-08" version="1">MALPSTGLSAFARLLAQSPAHCCKRRTLFGLNVKINKAGGAWKQRCCSYSILLSRASVCCSTQKGNMSVSHQNSQSKIDGKKSMCPNSTRSTHTGIPGDDFLFRQLLEYKSYTYTYLLADTHSMEAILIDPVIDTVDRDVRLVKDLGLKLIAAANTHVHADHITGTGELKKRVPGCLSYIAEVSGAQADVKVKEHDIIKFGRFQLEARSTPGHTDGCMTYVWHEKGMVFTGDALLIRGCGRTDFQQGSASTLYDSVHQKILSLPEHYCVFPAHDYTGQTMSTVGEEKQFNPRLSKPKSEFVEIMTKLNLPYPKQIDVALPANLVCGVFDVPTGPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A768</accession>
    <name>A0ABM1A768_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Microfibril-associated glycoprotein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101848229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012942175.1">
        <property type="nucleotide sequence ID" value="XM_013086721.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848229"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046647771" evidence="7">
        <location>
            <begin position="27"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="8">
        <location>
            <begin position="119"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012942175.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41955" checksum="3E39D97615C2C0B4" modified="2025-10-08" version="1">MGPISSPSLFPLLLLLTCLLAQPAHPWYTYHHYPQDRPVYTGSTCEGPGYRDLPVSVQNEHQCLVLEQLQTRVRSDLDLRRKQFTDIGARLKNLESKLSYTLKRLHRRNRDKTGVFPGLKDIPISRDCNELKNAGIQYSGIYPIQIPSGAIVNVFCDMETEGGGWTVVQQRANGLVNFTRKWDDYTFGFGNVNNEYWLGNENLHSMTTETRYSLRVDMWDWDDRFAYAQYNIFHVGPETTGYRLTVEGYREESTAGDSLKHHSGMGFSTIDRDNDNWSGSCARADRSGWWFNKCSFCSPNGEFQRGGYGSKFGDGKRTGITWYEWSKRPGYSLMRVQMKIKSYAAVIAHEEIEKTPNDGEDSVIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7N9</accession>
    <name>A0ABM1A7N9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Microphthalmia-associated transcription factor isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101853879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MiT/TFE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942440.1">
        <property type="nucleotide sequence ID" value="XM_013086986.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853879"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11397">
        <property type="entry name" value="bHLHzip_MITF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031867">
        <property type="entry name" value="MiT/TFE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15951">
        <property type="entry name" value="MITF_TFEB_C_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="316"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012942440.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="54574" checksum="EC673B373D542B91" modified="2025-10-08" version="1">MESDSDTVDTQTDHSSCPSSPGPTTPPPPRQPTTAASLPMDTVILVAKSRDGSKSSVVFRSLLRNRKAPGRVEKIRIIKSPVTEIKNASLPMRANLKQQLQRQQLLEQEKREQEAHVLGKSNGLHVTGSNSITVPRVVESAEVPVNVLQVKTQLQHPTKYHVRQSQKRQVQHFLNEHQGSHLPIQSLPANVVSVSAPEQQQYHVQSSSSAPDPDLPSPLMGAAADFIPSSFDLLGDLQSVDTLELGSLLGDSDLVEIQPSLGASSSGSLLTGYEGVDPEGSNQAPASCPTPVFRHQDLSHNGIMSVQDELWRKERIKKDNHNMIERRRRFNINDRIKELGGLLPRSIDPESRQNKGNILKASVDYIKSLQDDQRKLSAITEQKKKTESDLRKVLITLNQMSSVIQSHGLQSPHLDTNDLLTVKKLSMEFLTPSAPSPPLTTIMNTAPTSTQTTYSLTNMDDLMMDEMSPVSGDPMLLSAPVTPEGDDHSLDFSHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A961</accession>
    <name>A0ABM1A961_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhodopsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106013048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943205.1">
        <property type="nucleotide sequence ID" value="XM_013087751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013048"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="49"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943205.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38495" checksum="53126F6A4D1BEFC0" modified="2025-10-08" version="1">MASGNYSHTLPTMFEQDKDPFIDDDVLNVLIIVFYVVAIGLMCFFGVIFNAVNVFVFFKQGFKDTVNITLFSLAVSDMGSLATLFWSTVCFNPLFAQAVLPVISIDLMHITSGWPHTFFSRISSWITAFVTFERCLCIALPLKVKTIITPRRTIYVIVSIYIGVAACVAPAFYSIRLGPKHVSEVNMTMIGIVYTSDGVFIEGISLLISAFSQLVSFISVIVCTVILVQNLLIKSRWRQSSSSTAKQESLSNRDMKVVRMVLSIAVIFIACLSPTVANIFAIMSIPEYSFYGEYQSIYLILWAISFLLVATNSAVNIFVYYYMSSKFKEILDETLNRMRGKCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9F6</accession>
    <name>A0ABM1A9F6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101855595</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101855595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943366.1">
        <property type="nucleotide sequence ID" value="XM_013087912.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855595"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="310"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="730"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="909"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012943366.1"/>
        </source>
    </evidence>
    <sequence length="948" mass="106980" checksum="84FE102D7F513170" modified="2025-10-08" version="1">SEYLNMVEQCMNFACELMDLCRGTQEVEAVLSESDEGTQRDPLARLKMAIRYDEKKFVAHPNCQQHMTSIWYGSEMGFLQSLNGFMQFIYLILFLPAIPFMCLVYIIAPGSKFGAVMRCPVTKFITHTTSHMCFLILLAAATFRITESNVAITHTDDVNHPRYVHLTYEEKIQSLLKETLRPASTLITHVQICIVFWVLGLLWIECKQIYSSGARSYIMDYYNAMDFAVLSMYLSSYVLRFFTEYKVSEADLFFNGTHRANALLYQGNLTDFELFVAEVKDARHSPKNYFMEASRFQWEEYDPEIVSDVLFAIANVISFARTTQLMPAFEVLGPLQISLGRMIGDITRFMVLFTLGIFHSHQFFLGHSLALWAVGGLKQTFFSLFWSMFGQVSIGDIIINHPKTNGVRQCMTMDGDRTRIYCADGPFTKDEKNDTDNSALPLYMPENPQMENSTSLVETVGMYLFGIYHVVIIIVLINMLIAMMSHSFEDIQTDCDVEWKFARTKLWLNYMDDGSTLPVPFNMIPTPKSFLYGWTAVKDALGPGNNVVDYSKHKRQTFLKVMVNFSRFTYSLYLEVDLSYLAQRMTGTGYLKVDLSYLAQRMTGTGYLEVDLSYLAQRMTGTGYLEVDLSYLAQRMTGTGYLEVDISYLAQRMTGTGYLEVDLSYLAQRMTGTGYLEVSSQAVGLTCNDPPLLTSLALTLSHTCARPYLDIIDPQFKEGHGNIRAEEVEIWEPQDGPPPPVPETPSRIPYATPPIPEEEDDPKSSFNKSYKRKGGSRGHGRRTSSANVPIATTLAIPQLDAIQRSQKLLDMRLQQLQANHKETNRLQDDVEFIRRLMAENQKALCNVVQALANIQGEIVNLVQCLKPQPKTTRPPTNALVGSPSGPLTVVNAHPLSPVPAGGTAVLVERMPPDTCRIDRDRGGSGGRRDNNRDSRKRSGGVEEDESNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9H5</accession>
    <name>A0ABM1A9H5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipid phosphatase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106013109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943391.1">
        <property type="nucleotide sequence ID" value="XM_013087937.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013109"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF174">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="114"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012943391.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="30572" checksum="3673911A70CB60F5" modified="2025-10-08" version="1">MIAQRSVCSVFGLEAVVNSVINVVTFAAGVAALSAVHYLVPVHQRGFYCNDESIQFPYKTDTVSSASLFASTLGTAVVVITLSVMLQKCRPERTGEKTGSLSETGAIRTILHQIFVLLFGLVMTLLMTEIFKVSAGRLRPCFLSVCNVDADSYNCSVGYVTDYTCTQTNQALLTDSRKSFLSGHASVAFYNLVFTILYLQHQITEFPRCILPKTLLQVLCLSLASYICVSRVTDNKHHPTDVIAGAGLGVLLAVVADNVLTTMPALRRNRGEGNLQEVKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9R7</accession>
    <name>A0ABM1A9R7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-coupled folate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106011006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943545.1">
        <property type="nucleotide sequence ID" value="XM_013088091.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011006"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012943545.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43404" checksum="77684A657E5EDEE0" modified="2025-10-08" version="1">MTSQMLLELDLTKYGLGIIANLVMGALSAVVSRRVVMLVPLFGYLIRCVIIFLVVFLALDVNWLFAGYAVDGIMGSVNGIYFATYLYTSEITSRDKSRTLALAILESVKGAVTAAVYVVTGQLIQHTGYNWPAILSAACTLLAVVLAFALPPRPPRPSPTAVTKSSPLLPTPVEGYWDKMKTPFKQGRQKGLTALVTLACLAFFLDRISDFMVAKVRTLYVMNQPFCWSSSQIGWFDSGTQMACYLFTMVSVCLFARYLSGGVSVAIPAVLSAAGGHCVYAFATDDIELYAAPVLGMSSSLSSCLLRGETSRALGPQAQGPWFAVIAVIESLSFTLGTPALAVYRASLGFFRGLVFLIAAGLLLCEIFLLLAFQLKWRKFISRKGQTIVVPSATEDPDPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB80</accession>
    <name>A0ABM1AB80_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101856988</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944376.2">
        <property type="nucleotide sequence ID" value="XM_013088922.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856988"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052884">
        <property type="entry name" value="VID_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35261">
        <property type="entry name" value="ORGANELLAR PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35261:SF3">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="2">
        <location>
            <begin position="68"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1430"/>
            <end position="1444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944376.2"/>
        </source>
    </evidence>
    <sequence length="1546" mass="168111" checksum="AFEA1A7A712B0DD0" modified="2025-10-08" version="1">MGLSRKLGAVTQKPVVPETNSVPYQWSNQAYTVQEILAKFKLPSVVQCTAESCVVLWADFQFDLRQPLLLHSRRTVRKLHARSIRPAPDGTAEEFGPALAIPEDYEGWFAASPKGVTQVTRHLRVQSVASSSCRKFLVTTKLPAFSPCSMPDGTPGYVPHDVMPGEVLRRVCVLADSQNSQDTARVVKEQGACLECVDEREEAVLLPLNRRAIMYEVAEMYPGDGKGAFQIGAVTKAGNSCLPRLVTVVHGEPPVLDYAFTGVLRLYSVYTEETLLAGTLDDPKSICLELATDSLTKFRLGLNEAAIKKTCEYNNAQQICESFGPKFVSGIKVSFSLTPEYPDLDDVDLSFYENSSDAQEVNANNEFEIAWGSVKKAKLLTSSSASNDDVDGSPPSLSSSSAVVDDSRDDPSLAPPLSDSTTVVLQEVGVSADAGGRDQGWSEREEAWPDVTRHTDDTETETTRDLFPLQSVPASGPGVTTHDLTLRPPDELEAMSESRVTDNPLFYYFQRNPDTRPPPPSLPGEERDSDRGHLLDLSADNTRTDITRTDTQSDSPPTHPTLLPTRDSPHQPAVSELPTLPTHKRDHVSKREPIALARMFEPPPSAGRVEETTGGDIHDCGSNLVVGADIRVDKPESISYSEELCKSNSESDPTLVFTTAATTTTIINNNNNNNNNNSSNNNSNNNNNNNNNSNNTLPSGQPNVPARSEPTDHVTTPTDHPPFPPPPAWYTNPAGHAQTPAVFSQPAMIASLSSLSSLENVGVNDTPPRRRRGEKEEQREQDEEDYAEVEEVLAGFELDTVALTPAREYAESSDVGSDVGSDVGSDVDNDVEGYVSEESPGAGHGQHDDDDVYVVSWDKDAVTDPDIAGKTRADEHTVTPGLVTSEGRNDVHLGVASTSWAGDEETGDDNDDDLDNLFSFVQEHEDEEEEEEEEEEEEEEEEEEEEEEIIHPPETHYITFPSSEATEPPLASHRNLLQPTTTSPDIDPASDDVSTQPPVVMETDKSSAQAVERLTSLIDEVTTLVNTSSGRILDARRLDTSFERQSRDTSPSATGATTPATTPTGATYNVARTDTVASSVDAPSDPSLHKPSTHPSSLTSPTHPSPLTSLTYPSTLTQPTHPSPLTPPTHTDQTFTIIDPHSPQHPPTARHITLSTPHSKNPNSSPDNSPTNNPDPDLDRDRDHDRDRDADPDPDLDPDTTMTVDLSVSSISHPPINLPPDFPHTEVKKKKSTPWNRKKKLPGLAGVYTGPADSSFGGLRRSQGQKDLASIGQLPTSGADVTLHKFQSDSNLSSVIKYERPVQNRFGSSRINHHPHHHPHGHGHQKACAQSLSHNSSSNSSNININNNNSSSNSNNNRNITTTPPDSSYAQHNRPEDLHNLPTASRDDDVTLKATPPQQPASSSSYSRSTPHGSVLSSVQNFERLHSNISTSSSSSSISSSTRDSFSRTRPPPSRRDLDLGARPSSHRGAEVKVVHMADVHTPSAVAAAERDSRITPTESEEEEVVRIEEQFVLSKTGRLRAGKGGARRSVLVGLMSGEENEENFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB93</accession>
    <name>A0ABM1AB93_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101845807</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944393.1">
        <property type="nucleotide sequence ID" value="XM_013088939.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845807"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="7">
        <location>
            <begin position="231"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012944393.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44238" checksum="E59FCFEDA30F4E4C" modified="2025-10-08" version="1">MSKYMNDVDSKEPFIEKNHLSSGPSNAPMGDNHGNGSTTPANNISGSNNTNSSSSNGNNNSNYHYGGGAPPNNSNSMKQTSQQLDYSHLERTIARLRTYLFAMFGVGVAGFIILIIVVTVLYVNLNYDLVHHRHKPKVGEQAYEIMQKEELCVPCDDFRLGPSPEEERELKKFRLKEGPEGVSCCVDTPVELMLLLKMFVERRFRQEVAKGTISQWPRASSVVSGGSEGKPAAHLMITTQDLSDVKEEHGRQFIIGRWNYDADLAFTYRTTYRSGRIVIPEDGYYFVYSQISFMETFDLHTAEGYGSRHSSDVPSLSHYLFRYNILYHNGGEEKLAQNSITKCWGQSKTFGEYVSNLGAVFYLRNSDEIFVKVSNITMVSTDPKMSHFGLFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC34</accession>
    <name>A0ABM1AC34_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein sel-1 homolog 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944869.1">
        <property type="nucleotide sequence ID" value="XM_013089415.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858368"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042756">
        <property type="entry name" value="Sel-1L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44444:SF6">
        <property type="entry name" value="LAMININ G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44444">
        <property type="entry name" value="PROTEIN SEL-1 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944869.1"/>
        </source>
    </evidence>
    <sequence length="1137" mass="130106" checksum="DBD5DCABAEB2C20B" modified="2025-10-08" version="1">MTGRNYIYNMTSFASVVLAAVLYSRIVTASQEVILDADFGHLERDHQETHTSNVRITKAPSVLKQLRKVTVEYYCEEDSVIVLDLSVMLQDADAFSVAFSKAWICQGQHGEGAPRLKSIHLRLPRPLAYRPDYFNKEAWRVTGAAKIRAWLVNFDTWLNTEPGGGDLYASARCRDFQSVKVLPPYSRPHESPPCAVWYWSHAQRSPRLSDTDHCPLEQELVTFLNYPAVFNGNAYGIVRQLFPHHDPGLEAGRVHTVWAPQLTIEMWVYFLEFCPLSYMSPTGTCGLLLHIDRQGLLLSPSLLVHENGNIQVDILGKGGHISRLTIGKATKNVWTRILFTLNSRTWSVHVNHGKDLEEGFWTVYTYDEDVFVDDTYGLWNLGGLDWQVGSFIGYMGRAIFHRRRVLESYQIPRPDPFHPMFELHLTSREEKCQNFLVWMDSAVSVYQRYQKYLLRQRANICPNEGYRLFEMFLPVSGPELRICPMRHPRGLRHHRPVKRLLRKAVQRHSLSWNFLDGEMEAYSRRERSEGREVLLNISQGLISNATDLVSDKGLAVSTRAVQLLKQAACLGSDDAMFSLAVLLNNGVGAAVDEIQSLAFFMLGTLNRHILSIMALGHRHVMGIDGAPVDRDAAFMYYKQVADQSRRDKEEHKDSEIATESIRLIDEARIDAQTSEVGDLFLWLKHQAQNGVATAQSELGLMMYHGAQGLQRNLQNAMQVFREGAEMGNVDAMFNYGIMEYRGIGVRPNRTRGRKMVEKAAKLKNPHAMTALGWMALEIDHNMTQALNMFRKAKFMGHMDSGYYLGHMYHYGMVPQHPVDLDKALEEYLWSGNRGQIDAGTLYAFLVSRGTPKYPRDIYFGTEWARFIGEKNSFLAKPLREALNAFRDGNHALALYLYLLLADTGLEVASFNLAYLCEQNRDGVTSYLSKECQWRHYNMTTQREFHQVDAYSYIKMGDYYWYGCRGRRDLGQAALHYSYAALKGDPHALFNLAYMVEEGAPVVSAVWNSLQIPVEAQQTNVSLLLELYARCRESLRSEAFIPCSLAWFRVWCRDVWEQYHVYMKVTSVCGAVVVCMSVIFLCAHFLQQRRLRRDEESQREAEREEEDRMRAEEERERHGDGESAAAVPQHAVGPFEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACF8</accession>
    <name>A0ABM1ACF8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">RNA-binding protein 24-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101845137</name>
        <name evidence="5" type="synonym">LOC101862344</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097477.2">
        <property type="nucleotide sequence ID" value="XM_005097420.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012945053.1">
        <property type="nucleotide sequence ID" value="XM_013089599.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845137"/>
    <dbReference type="GeneID" id="101862344"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12384">
        <property type="entry name" value="RRM_RBM24_RBM38_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005097477.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012945053.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="25992" checksum="CC876A05EC32CFA0" modified="2025-10-08" version="1">MAVTTPTMLSITGQKDTQFTKIFVGGLPYHTTDQSLREYFDKFGDIEEAVVITDRQTGKSRGYGFVTMADKMAAERACKEPNPIIDGRKANVNLAYLGAKPRQNGLASVLPYAIKSIPGLIPGQYGYPAQYVYPASYLAAASATSPGVLTTMPATSPLSPTPTGTPTQYALDYASAYSAATAAQFAASGYEAYSPYTTAGTTAAAAGYGAVAGVPAGYTYAMPQQLAASTTHFAQFQPQQIQERLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADD9</accession>
    <name>A0ABM1ADD9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101859613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945541.1">
        <property type="nucleotide sequence ID" value="XM_013090087.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859613"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="375"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1292"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1292"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1328"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012945541.1"/>
        </source>
    </evidence>
    <sequence length="1378" mass="155216" checksum="8DAB8BCC68E3A8CF" modified="2025-10-08" version="1">MAGITVTEDNRKDEVQKKDPQSKDSGTDSTKECLTNGHAEEKIILDGKAEQNCCVGEKGQCTMEKKEDKEGETKENEEEKDKEVLLIQDTGFNVVIVAPGIEPFDLPVSSMELVQEIHQVLMDREDTCHRTCFSLQLDGTTMDNFSELKAIEGLKEGSVIKVIEEPYTVREARIHVRHVRDLMKSVDPADAYNGVDCASLSFLNTITLGDILDKKRSKPDSVDCTPPEAIIPNSKDRPLLPLHPGIKDLKGSRCLKVLTYSGWNPPPGNRRMHGDLLYLYVVTLEDKRYHVTSCARGFYLNQSTEDEFNPKPSQPKYLSHSLIDLLNQISPAFKRTFSLLLKKRGQKHPFERVPTPYQVYAWMAPQPDHQVDYIRAEDAFSTRLGYEEHIPGQTRDWNEEIQTTRELPKTNLPERLIRERAIFKVHSDFVAAATRGAMAVIDGNVMAINPGEDAKMQMFIWNNIFFSLGFDVKDHYKDFGGDAAAFAAPSNDLQGVKAYFNMDPDGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQSVVYGSVDFGKTVVSSEKYRELLQKTAAALKIRPHKVLNSKEETIELYSSIECKGIVGNDQRHYILDLLRTFPPDANYLPVEGEELAEFMKNHGYPKNHRHKLPCLRQELIEAFIESRYLAFVKHAALHFQTLQKQPKKTEEKAALTNGHGCDENKNKIDEDEVTEEAKKLVETMTGSQDAVSRKTVEDDTREIVRKAAEASGSMSETEFSITFNPDVFQPHVRHAEPESEMFQKEKDLVKKASQHIVASQIPLLINDCLDHTSSPVDGITLSESMHARGINMRYLGKVAEMLAKYPTLSYVYTIAVSELICRSAKHLFNHYMQGVDMMNTAAAISHFFNCFLGSYPTPHPQVTADESKAAKRKSKRKNKHSVVFSIENTEWSSETPKSLWKKIIDEADEYYSYVLECDGIDGAMEQYGCQRVALLRSICLKCGVQMQLKEYSLENKGRPCFSEDDIVNVYPIVKHISPRATDAFHFFSSGQNKIQQGLLREGYELISEALNLLNNVYGAMHPEIAACLRLLARLNYIMGEFAEAMSYQQRAVLMSERVLGVDHPNTITEYAHLALYCFANNQVTSALRLMYRARYLAIVCHGENHPEVALIDSNIGLILQAVEEYDFSLRYLEHALQLNIRYFGSESLKTAMTYHLVARTHSCRGDFRSALQSEKEAYTIYKSKLGEAHERTKESSECLAHLTKQAVVVQKKMNEIYKGEVNSTLPPIQIQPPSLAGVLETLNIINGIVFVQISPDDLEKFKQEMSKRQSVEQGQEDKPAIDGSPEADKDKGDGDKAPAESVATTAVKETTKVEQTTKATVEVPSKPVENVNQNKKDDSAVLVEGIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPP8</accession>
    <name>A0ABM1VPP8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nesprin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101849911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824390.1">
        <property type="nucleotide sequence ID" value="XM_035968497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849911"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21243">
        <property type="entry name" value="CH_SYNE1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047291">
        <property type="entry name" value="CH_SYNE1_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057057">
        <property type="entry name" value="Spectrin_SYNE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF1">
        <property type="entry name" value="NESPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25034">
        <property type="entry name" value="Spectrin_SYNE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="36"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="162"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="716"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1245"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1774"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2427"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2536"/>
            <end position="2563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2784"/>
            <end position="2811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="3062"/>
            <end position="3132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="3327"/>
            <end position="3405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824390.1"/>
        </source>
    </evidence>
    <sequence length="3473" mass="401672" checksum="620B8762285FAAC0" modified="2025-10-08" version="1">MSSRFSGLLGNAQVSDRSQEKAFIDRVHLLKDEQERVQKKTFTNWMNTYLCKRSPPIKVENLFEEVKDGVVLLSLLEVLSGEKLPMEKGPRLRRPHHLANISSALNFLEKKKIKLVNINATSIADGKPSIVLGLVWTIILYFQIEETINAVPDGDGTKKKSTLPKQSLLDWAESVLSKKYGLDIKDFGKSWKDGVAFNAMIHNIRPDLVDMDQIRRQQARINLEHAFSTAESELGIPRLLDPEDVDVEKPDEKSIMTYVAQFLKAYPDAGGASGIPSLNIDTAEKEMKAYNSLMNWLNSDAAEVLATSQEPIQDRDSEFLDYLGFKTELDRREPLYLKIGEKVLSGRALKITRGDWEKLDIRWQEVDEQVHLWLLKLDSSLPGKLGKLGEWLYHAEKLLRKKEEGMENPDDMAALYAELAREHREFFKDLESWKQFYAQIKRAGRYEGMMLQGRQIEHLSKRLETVTMLSTVRQNRLDYTHMRYKLLAFLVVAEAKLNQWTAKYGPQEAVEELLVDYVDFVERQRMLESFDKTFAETKKVSETYKMGGADKMESSQIDHFLEEILGRWKKVTVEVKSVRSMMEETINTWKRYAACVDVLTVWLTEGEQVMRLSVEEKEEYFKDLAQYEEKHKILNESANFLIDVSSDPVAAEIKETLLLLNRRFKDLTEGFQSFRQNEVIGKARAEYETGVATLESWLGETSDILSQQVRCVHAELKAYLLELDNYNNQVQEIENNFKITTKTAQSLVKDSTQESVNEMLQTLNVQKEAIVKLRKEIPERIKYLKAVLPNVESLETGILDLQRWLEEGEQLLGSHKLDGTADETEARLERHKAFFTETTYQKSILESKNKVFQKISGTKSKLKNVDFSPAEDLMNSANDKFQNVVTSAKEWERRLEGLARLWRSLLQKQQGLEEWLDNAQTILDDTDDDPDSLIRKHRAFFDRVDKRMMSDYESTANEILQQLEAGDRKQLSQTLAHLKERWDHVMHHAPIKLLKLEFAVPEDKFEAAIGKAEEALQQQQEQIKRNQNVKEALIKHRQMFQEGGFAASCEQLLEQMKGLSQGLLKLSRDERSLEQRYKNHQDRWDKLRLIVEDTHLQLKQLPERWRDYHQKMEGFDNWLQFVEKLMKEMGQEDLTGEEYRDMLAKFQFWKEMRNMGKYQEDAKWLEQALEELIKDAPDADARRERERLKGVLERFRGIRPHMDSAMDKSGILSKGYEYRDNVGKKKSWLDEAQRLAMEHPNIDSLEDARAYLHEHETLLNKLDAEKASIQAEIEAGKRLQRDRNAPAFIEQSVSELDRKWKDTNELAKAKHEKLKQQVKDWESYEGEKSKLLTYLKKAETELERPVETVNQENAQKDFNSKKELQSTLNKLKGSLSEMTKLNSLLAEGASRERQGPLKSEMTDIDKKLENISHRLNAKLVDLESTIAKWSEYYKRLNSFCDWLNEKETKLNEIYENKQDSPETQLQKAEGISSQVYENHVTLENLEKDARGLTQNFRSRETAALKSKLTSVRRQWESLCARAKDRSTALSGNVAHWQKYQTLQEQLLPWIMKAEKYCATDLPKCASLEEARELYDLHQAFLQECEEYLPLFDQMSTEAGYLLDQPNMHRDLEAIQKRWGSILTNSEDRSHKVDKTFGAWSAYANELDNFQETLEKIHGRLATEPNVNTSDIQVLEHELALAKALQEEARSHQPQLNALQRQFEQVQHHASPEGLGVVKSKQDAIKTNWNEINEAVAERQKVLGAALQHRRDFYNRMQDTEKWVKKMQRKLDSGNEIYSDELPDTQAKLKAMKEECQSQEALFQGLQQEFKELVSVCSPDEAAVLSERFDKMMQGYTRVEDLIGNREELCGKWVAYSDAQREVQTKLKALQAKLASPDITEEEVAQCMREIEALRKSMQPWTQDADTLDDLMSTAQMMIKDRATQRTLHFSSELQALENLCDQAGASARQKEEQLGELTQLSTEFLQRKDGLAQNLIEVQEKIMAARASKPDLQGMKDLVREIEDVRDDMYTNNPEYEQLRELGRQIMHTDPTKAAVIQAQLGQVNAAWEEIQGLLTERHQQYSGVANMWQQYYDAKQGVMKILEDVDPVVSQDLAFMNQGDVKKSLDQHKNAEFELHANQTQLDHMNNKGVQLLEDLRNIPDFDLSGMESDLDEVNLKWETANSVIDHHKEDLEAQLVCWEQVQSGEEEVRTWVNAMVNKLDDSLKHFDDAVSVESRLNKFKDEAPYFEEVMTEVEQKLKDLKELNKGQDIPTLTDAQQDIKAQFEKASNLANQLDSMMSSFSDEQQGLQKSMSDETEWMNQLKEALTKCDDVTGSTEELIQRFDTCKNLQQELASHQRQITAIQDRTSSLQKKYPSSETASLAKDGVVVTKKYEALVQRGERVQDALLGQLESQCAEAQQQQLRWLNAAKEKVSWCGDIAGDRYSIEAKLATIKDLEASLQDGEAKRHEATNRLDAIKGVLPKAKQSELEANRKSMEKEWQNLVKQLQQTQSKLETSMEQWQQYDHRYEALSQWLKDTETKMRAESALKPDLPSKKEQLELFKSLEQAVQSHRNEFENMRDTAQQISHTSGDSRTASYAGQLVNRYQTLASAIKEQLERCHQNIEDHEQYVDRHKAMQDWLTMATQELQQCSDLVGDEDSLNTKLSIVKDLVAQKEQGASCFNSALEAGEKLYPNTSNEGREGIRRELRSLRDSWEGFNDSLSDTQRQLDSSRMQWQSFDENFEQLQKWVAEVEAQMDSDPELKATLQEKKALLQHYKTRCQDIMSHQTMVDSISDKGTALSSAQVQNKLKQLNNKYNHLCNAAENCVRKAEEYVDEHQSYQDVSQLCRDWLTATRDKVAVCAEVGGDKQALQNRLDRLQDIMATMGDGETKLRQAHQQGERIMPHTSPPGQSNLRRELDSLTADWDALVTRMDETQQGLAQAIQALDLYDGSCESLNRWLRETESQFKDSELKSTLREKQAQVDMFKSLQQDISSKQDQFTDLQNMAAQVQSTDTRLANYSTQLGTRYETLKSLAKDVIRKWEEYVEEHQTFQQSHGQCMDAVDTLRRRLQVCADLAGDKQDVEDRMIKLQELMAERDEKANVIHQTIESGERLYPSTASDGRDHIRQDIRNLRENWEALRDEMSDVQRKLDVNLNQWSSYDENFEGFQKWLLDMEVKLKEDAQLQATLPEKKAQLQNHKVLHQDILSREHIIENLAEKAQALTHSTPSAKSNDICRQVNKFVGELQGKYSGICDASKSILDRLDSSMRDHQQYQDASQDFTDWLNSARERLEACADRSGDKLSLQGKRERLKEFAANIHEGERKLQLTRQYGATTSQNTSPQGRDVLQRELEHLEREWKDYLNLMQHAEASLEQTMGMWGDFESKFEQFAEWLKNMENKVKGHELKNTLKEKQVQVEKFKKQREEILSHQPEIDRFTDDAQNLMHTSSDVRLSTQVSQLTNKYQGILSLVKVKHSSFLFVMSYEQEASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQM5</accession>
    <name>A0ABM1VQM5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine-rich and transmembrane domain-containing protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824717.1">
        <property type="nucleotide sequence ID" value="XM_035968824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847864"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824717.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17147" checksum="D6F97203D4DA3DE6" modified="2025-10-08" version="1">MLGPMRGYSAKNACDKMSVHPTPGAPPPPYPGDSAYPPAPPAGYYGGPPPQAYGGPAQPGYGPPPPPAGYGPPPPQGYGPPPPQGYGPPPPQGYGYGYGQGQAAPYPQQPYPQQPYQGGPYQQQPAQQVVYVDDRRKNNDRDNSAETCCIIGLCSALLCCCLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQR5</accession>
    <name>A0ABM1VQR5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101847325</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101847325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824757.1">
        <property type="nucleotide sequence ID" value="XM_035968864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847325"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01472">
        <property type="entry name" value="vWA_collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047200002" evidence="3">
        <location>
            <begin position="21"/>
            <end position="3773"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="205"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="451"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="775"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="890"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="1189"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="2356"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="2440"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="2541"/>
            <end position="2607"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="2759"/>
            <end position="2826"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="2861"/>
            <end position="2927"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="3184"/>
            <end position="3249"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="3320"/>
            <end position="3354"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="3625"/>
            <end position="3696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1850"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1952"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2126"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2611"/>
            <end position="2638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2933"/>
            <end position="2957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1972"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2611"/>
            <end position="2623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2624"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2945"/>
            <end position="2957"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="3320"/>
            <end position="3354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035824757.1"/>
        </source>
    </evidence>
    <sequence length="3773" mass="408217" checksum="BFA220E4F779E2CA" modified="2025-10-08" version="1">MDRQLLLACLTTLLLGLNHAQNTRDADVTVEANNARRDHIGLISVGVGPNVNTGELQAIADDPDKDHMFNPQDYSALAGLSKKIIDAACTVQTTAPSRTTAQPDLSFDIIEHLSSGAVLLECLPEFCIVYPVKSLLLVYKDDVGFFVVFHCFLSYLSCYISALNDLYSVATLLISQTTKAHTKEGITFNFFSCQSFPPACTGYADVVFVVDSSDGVGQADYQKELDLVKNTVNKMNIGDRGMHVGMVTYGTSSKTVFNLKDNPTAAALNNAIGNAPFVGGTEGMLGALQTAKNQMFTPAAGVRDKTSRIVVLVSGGRSNNAALTKLRVSTEYLVLRTLFEVTAPLFIALYFIENYAICFIDSIRKCQEYYFQADELRANDIDVYSVGIGAGVDINEMNGIASDPDTRYVYTADNFDSAQALADVLGPKICNEIPEDPKFLPPPTGCLQKADVMFLLDSSSSIGQNNFQKLEDFLKNTVKDLDIGPDKVRVGMMQYSSYPSLEFPLNMHGSRYDVLKAIDQVKYMGGGANTADALRYMRQLGFSQNSGARADVPRVAVVITDGSSPNRFVPSADVTVEANNARRDHIGLISVGVGPNVNTGELQAIADDPDKDHMFNPQDYSALAGLSKKIIDAACTEASKPLLHQGPQLSLLSIYRSVYLSIPSSSSGGTLPPDPCKDKISTCANYGSDLCTGTYKTWAKVNCERYCGICSPLYTVAPPTCNDVINDCVSYGIASCSGSYRPYMEKNCKRFCGYCGIDTQSLGFCNTTQTNVADGSCAYKGQTYSTGEKWSDGCDYECVCEDGKTGKYRCYNKCPIYHNLPADCTLVKDPSSCCLQPQCNFDQTVGTTQGANKGSRNGIGKSPKPDILLFRFYQKLHDTSSRISSEDWGYTCVYGGKNYYQDQQWQDGCNAQCVCVDAKTGRHECHDLCPTYTRLPSYCRLEKKTGACCPTPVCEFQNQQGTFTGLGTISSNGIGQTPATLPPCVNKLNNCPLYGKPACTQYAQWAFDNCRDFCGLCGTGPAPGPNDKCLYQGSQYSQGQSWFVGSDKQCTCENAVSGYYRCTTLLVKCSLRPTQRSVLKMKPQLSRRCPTYTNLPPTCTVKTVPGQACDVITCPSGTFISSSNNLATLGNGGNIQKDPASGYVPPTLPSGAAVPPGTGGSPDNAPKLSELGLQLLYFNPHLFALKSTDGCLYNGQLYVKGQRWNDGCSKSCECLDGATGRTKCRQRCPDYAQVPAGCTMISDPDDTCCHKPKCSDPNVVPVPHFKPYTTTNTPVAPPPNNDRFVGTGDLFGPHGGKYTVVQTGTPIPTPGVGVFSTGGIGHCEYKGKQYLQGEIWEDGCDYNCVCDDASFGHYTCTQKCVIYTNIPFPYCRLIEDPGNKCCKIPSCVWTAPYERITDYLVVNPTTPAMVASSLPPTPAFAFCVYKGKSYDQNQVWYDGCDFKCTCEEPSTNKYRCETRCPDFPNVAPNCKFVADTKDPSCCTVPECPTPSPLPGVSPDPTPTGVPGVITGGVDPPGTSSGNNKGFCEYQGKQYKQDEKWDNGCEFSCVCEDAVTGKYKCTEKCKRYTNLAPGCYLVDDFANPCCQIPRCDASPNTQPTISPNQNPGSTRTPGNKGKDRLFGLYQWGSLSLSLSLVSPAFCVYNGVQYTWGQQWVDGCDKKCQCDNADTGSYSCTERSVLWYQCFTYDNLPPECKLVTDPKDSCCLVPECGTPAPVATPAPPTLPGGSVAPGTQGPNPTPVGTPVPTPTAVVGKITGVPVTVPPTPGPDGKTVAPPTLTYCEYKGTRYNQGQKWNDGCQFQCECVNALVGKYECTEKCPRYVNLSPLCRLVRDPSNPCCEVPDCQPNPNSPGPTLAPGSTRVPTTASGPTPPPKDVCVYKSQTYTQGQKWFDGCDYSCECENANQGLYRCDNRCPSYDAVPKGCHFEDDPSDPLCCKVIRCDIPTSLNNQTGTGLIPTPPPAIKEGGYATPAPTPTDPNAPPPLPGQPTPSPVPPGVCVYKGRQYQQGRRWQDGCDYNCECLDGTGRYKCTEIQGVCVYNGVPFTQGQKWNDGCDLQCICENATTGFYRCNQRCPKYTGLPKSCSLIPDPNDPTCCEIPQCLPTPGPNQPVTPGPTQTFPTLPTGSVTGNAPVPPPTTSQPGQTTVKPPQGCMYKNTRYAQGQQWQDGCQYNCVCDDGITGKYTCTQRRDKLLYGFCEYKGQQYQTGNKWIDGCDFNCECLDQIAGVYSCSQRCSPYPNIPSYCILVQDPKDQCCEVPYCPGAATLSPNPNQSITPPINPSLTTKPTATPYPTLFPALATTLKPPPGGVPTKDVCVYMGKSYTQGQRWDVGCDKVCVCEDGKTGGYSCTDRKAPPPACVYKGSRYQKGQTWQDGCQFECVCLDDMSGQYKCTDKCPRYPNLPVICQLVYDPQNPCCKKAECPTPGPDGLIPTPAGTPVPDVCVYNGVPYRQGQIWKVGCDKICVCEDAKARTINCDDRCPTFQAVPAGCQLTTDPQDNCCQVLDCPVPPAGQPITPLPPKFVTGKNVPAQNPTPFTGGTSDVCIYQGKVYKQSEKWQDGCTFTCVCTDSTQGKYMCTDRCPTYPKLPPQCTMVQDPNDPCCKKPFCARTPAPPPGSTPPPGQPTSPGTPTNGPTPIAKPPDMCEYNGRLYKQSQQWYDGCNKVCKCENANMNFYRCEDRCAVYSKIPSGCSLVPDPKDPTCCEVPDCPVQIGASPTAGFVPTPANPTPGSVTGIGKIPTPGNTPKPSPGQPTPPALPKNGCFYNNTVYKQGDKWTVGCKLSCVCSDGVTGKYECNELCPPVPSNLPPVCRALQDPQNPCCPRVYCDSLNPTPVFPTPPVNPSDDPQVYTPGPTTSFTGQSGYCVYQGVYYRQGQTWQDGCSKVCKCENVTTGYYSCKERCPTFDNLPPQCKLIANPNDPCCVVPDCNTFPTPAPTGPNGQTLSPPSGPTPPPVFTPTPAPPGIITGTGNGPAGMCVYNGKSYGQYQAWNDGCDYKCECIDAQRGQFKCTDRCNKYYGPIPQQCYKVPDPSDSCCQDLKCDMKVTLTPRPQNVPSTTALVIVQDKCVYTNGKQYGQGSIWSDGCAGTCRCIDATVNNYACNSRCPVYSSLPKECTLTPDPNDQCCMQPTCTGNFKPIIGGSGPTMSPTLDPSQTNVFPIGTHTTLTGSELPPPPGPGNTITGQRVGCVYSGVVHRQGDRWNDGCDYVCSCVDESQGIYRCTSKCPQLPPMPSYCSKVTIPGQCCEAVSCNLPGKGYYSPVPELTPDLIPTPGPVPTPGQTTPMTYVVGIPPGSTTGTSLPGNGSPVPSGTDVTGLRADDSCKDVAPNCPDYGINACSGVYKPWAEKNCQAYCKLCPTKPKDQCFDLLDSCSNMGPLYCSGVYQTWAQKNCNKTCNLCNPIIINVQTNGFSGNTTGDNQVSGGNNTIGRYSQYGWATLLKGVTNAPGDLWGLWTSKNTSNEKNPVAMELSNRLKEHYKPDLSNYWNDCKFDMIKLSLMTNGKEDGYIIFDSKGTDKLSWFDSSRIINSTFSDLSSSSNFDAFTSSGDPNTGRHFVITQSTRSCDIKGWLIMSTRQDCFFERGVQPGFHYSANGKVGQFGKDTLRSDIMVISGYGGKCFNGTIGQHKRVCPYGGKEYNTGDEWQDGCEKKCKCIDANFGYYKCDPLCPPINNLPPGARIVKKNGTCCGEIVQDNTAGCYYQGNFYAQNEKWEDACDYNCECVDASQGFYQCSAKCFTFQNLPSMCKLLSPPPGKCCPTVSCPPGIVINYPDGYVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSB1</accession>
    <name>A0ABM1VSB1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">AT-rich interactive domain-containing protein 1B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101854323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825303.1">
        <property type="nucleotide sequence ID" value="XM_035969410.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825304.1">
        <property type="nucleotide sequence ID" value="XM_035969411.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854323"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16865">
        <property type="entry name" value="ARID_ARID1A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021906">
        <property type="entry name" value="BAF250/Osa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033388">
        <property type="entry name" value="BAF250_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656">
        <property type="entry name" value="BRG-1 ASSOCIATED FACTOR 250 BAF250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656:SF5">
        <property type="entry name" value="TRITHORAX GROUP PROTEIN OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12031">
        <property type="entry name" value="BAF250_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT67</accession>
    <name>A0ABM1VT67_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101856893</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825609.1">
        <property type="nucleotide sequence ID" value="XM_035969716.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="17"/>
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            <begin position="18"/>
            <end position="530"/>
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            <begin position="351"/>
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            <begin position="369"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825609.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="59158" checksum="EF3CC71B1BC189B5" modified="2025-10-08" version="1">MTVGVVVLPYIIPMLLGRTFDMFTSQVGVDIFPQKSIENPIVIERSFVHSDFRVIRNDSEARHFLGVTDDLSLRVKAGVLHIAATGDYLKDVQTRENYVEILVKSQDKWEGEGLFYQESPSVYWENVPYSAYVGPRSPGFSTFDGQVDHRPGEVKVRQEYHSFEDKLKRMVYAAEEKMGNDLGIRIKYYSTVTAPYVPQDIDSFLKLLEDFPAQAEKLNGGRGVPLKVELVPLHELSARMIALRPNKYLEKTLEDMDDKFSDLLVTHAAIRSISEKTKPKDYKENCEVHDYGSDIHGKLDVFKDVIRRLDTASPSALFETKRALQAYEQKEEPDDKWGYYKKLKHIKEDVEHTEELTGGAHSKNKVSSKSHAEQNGQQLHVVPVSGSSRGATSHSNGGGSNLMSSNFTPLDHFGYLAEMSMANGVCASLNKFSGSFLTLRRNCTISGVTCSRMCWALQEHVTPPLGNGAPGPRVTRQGGECVGVVVAELHVSQDVAVGARTINLGRNACDRAHCYHEYCCCRMGGRIGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VU66</accession>
    <name>A0ABM1VU66_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC101851953 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC101851953</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_013083178.2"/>
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    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AT15442P-RELATED"/>
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    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="363"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
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        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
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            <begin position="24"/>
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        <location>
            <begin position="651"/>
            <end position="696"/>
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        <location>
            <begin position="32"/>
            <end position="45"/>
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        <location>
            <begin position="53"/>
            <end position="66"/>
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            <begin position="73"/>
            <end position="97"/>
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            <begin position="136"/>
            <end position="150"/>
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            <begin position="152"/>
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    </feature>
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            <begin position="679"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Proteomes" id="UP000694888"/>
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            <dbReference type="RefSeq" id="XP_012938633.1"/>
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    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035825958.1"/>
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    </evidence>
    <sequence length="775" mass="84213" checksum="CC7EA64CB74834CB" modified="2025-10-08" version="1">MARVLFIVCVPASEEEKIEKPGIFAKDVGGGDEDKAVLKAVENDMKPVGNNADESKTKKEKGDSNKETTAVAVDKESDGVTLTKKHEDAPEENKDADSANESSSGVDEQGFHFGNAPKKNAGIESKEESNPVSTEHTSEEGLKGTEKGDTSDSADVDEDTTTGDGEKQPVYERFISEHWTLLEKVKTALEVLRVTSVQWHLAEDNTYVAMFITGDGERCEEVLDKLAKLDVGVIPRSSVSVFPASISAAEEEEVDTIQKMIEREDKLAEKVTEFKKSIKSRLVVAQVVDSVKGDALFTFDYLMLLVLASLVSVMGLLESSSVVLVASMLISPLMGPILAGVFGTVISNEQLRNLGCKSEIKGLVLCILVGFLTGFIPAVLELGGLSWRSSDSWPTFEMSSRGSLRSLPVGVLIAIPSGAGVALSILGGKVGSLVGVAISASLLPPAVNAGLLWANAIVVSISPPLTVHRGQMRLVPTNSTANATSATLVPVGGSGCRELVNNDYINQYSCDMGVENLILGVVSLLLTVLNILCIIIMGILVLKIKEVTAPSTQTSQGPEKDFFGKDLKVARQSYQTAKGQTSVIMGKKILEEYQKIKLQVGCEHEESEDKAELFKIMEDMEESPVVQALREQLPGKWNRWDRLSRPSSFFHDPEDDNDHHDRPYHTINLGRSGASPTHNDVELQEKPRGSRSAEPRVNNVEETNYFTIHRYIPASDLLRSRTSQESGRFTQKLIIPKASRFQVAKVKVRDSMSKLDAIEETVPLLETKSGTSVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUM9</accession>
    <name>A0ABM1VUM9_APLCA</name>
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        <submittedName>
            <fullName evidence="3">Trithorax group protein osa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826121.1">
        <property type="nucleotide sequence ID" value="XM_035970228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477837"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826121.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="40001" checksum="99E9D3FFF243F844" modified="2025-10-08" version="1">MTWSPRNKPGEQDDDDDDDDNSKEKTENANNSDDDSENGKTNREEQHSTDRDPSRPSEITEPSTSATSMHAGRMYDPGPEPPHPPHSHLQGPAHSSDLSMPRRPQSFGNPHMASSGTPPSFLNMPAPSQVQGYSGPSSGAVTSQNGAMVPPHMEGPASGSLKRPDSLCSNSNDSGLSDVNCTYSEQTLDGLRPKIWSLAHVATSEPGYMNHAVTPSGNSSSSSSNSNVNNSLSRNLSSHPRGLIGGPMPTGGMGQGHMPPSMLAGSMGLTDNTHLSSVPPPPSSSTPSSMPPLSGHMSHQWGSIFGSHGLGGAPLGGAGGGAGGKSPCGPGPLFPPQSIPPGMGPGMPNGPPNTMATLHSSSPSPSAYNQNMSSPASYYPNQKMTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VV34</accession>
    <name>A0ABM1VV34_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ficolin-1-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826276.1">
        <property type="nucleotide sequence ID" value="XM_035970383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857651"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826276.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14817" checksum="A32EFF5057B3F9EB" modified="2025-10-08" version="1">MDGEFWLGLRNIHELMAGKTHTLRLKMKSGGSSYSKLYSTFGVGAGPDYKLSTGRNGEANGLWVNDGSAFSTKDHGPKKNCPSTRGGGWWFSGSNCGYTNLNGQARQANYLGMYWYPIRNSHYLTETEMAFRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW90</accession>
    <name>A0ABM1VW90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101845013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101845013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826682.1">
        <property type="nucleotide sequence ID" value="XM_035970789.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF107">
        <property type="entry name" value="DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="4">
        <location>
            <begin position="1184"/>
            <end position="1499"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="254"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="336"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="923"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="800"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035826682.1"/>
        </source>
    </evidence>
    <sequence length="1504" mass="164367" checksum="E987D1CFBB1A4801" modified="2025-10-08" version="1">MRSSTHYVDDTSTRLSVRCSKHRVDKTSSSQLSSTHGVDHNNTQLSSAHGVDRNSSWLSTTHCVDNTTNSTQLSSTHRVDDTISTRLSNSNTHYYVDETIISPAGDNPKTRYDERKSRRPRPAPRTSALYGNATTNVIAAKPAARSTTATTTAASSRDNRDSEEGDNGRRAAAGPFTSEAEQRNKCIDSVYIIGKPPTSERPDSNHHRRSRRVSGPLSDENTASSDWTVASSDWADSGNGGGCGGDGGARRKVRQSGSSGIFGLYCARVLRETQNQDQVVPRGRTLTRHRPGAEHRSVVQGSGQTVTPHRANTEHSSGAVESVEVRIGETGICSQNPEPHLRHHPHHHHLQNHSTSQTAVVDSAKDRHGETVTRHRCAEHPTTVSDSVDDGHGERVTCCPNHEHHQNDRVSLTGVGYVGAENRSGGTLTRHPSTAHRTTVVRSGGDRRSEIVACSQNHSNFQIALDDSVEDWNGEAVTCNPVLVSSTSQTSLQVREAGRNGLTVERGLGGREEGRGEGREEKLGGSEEGREPALCHSSERPDYSCAPCMCSVRPTNHRAGMTGRDQSEADIASFHVSPPPCITAAVADPASSTRKKKKKKKKKNDGFPESPQPAPFCFPSSGRDSAGDEPIAPDSSRLSAHQHTMPHGVSNGVPETITSENSDIPAAHRRGWNPSHAAVQDTASASSDAACASQQPADHSSSLSVVEGQAVAENDVKQRKKRRRRTKRTLVDTSQGAVCCCSPGGGGGGGGGGGVLLPSTSSPCQGCWSPSGASPPPQQHQQQQQQQQQQHHEPDSGLDSSSQSSIHSAGSSIHSAGSSPLPPLDYHHHHYQQLQQQQQQTDSRSSSAERLRICSSPNFVYDPDVVNEMPFYFTEPPLEDFPSPREMVLPDWVLHDSLSGEERGEGEDGEEEDEGELWGDWPEEEEEEEGEDHDASVAELEVRDTECDAVSSRVGRVEQSSEDGLDKLVGRTSAAGGVMCLPVLGEAESGLAVTSRADEVTEDLDGVSDIATCLTSSSDGNTDESEIDYDAYLPAHVLMHVKRDLVSVLMEYGQTREVKVTFQDMERSGPHHASRFHTAAIVDTETFPIGSGSSKKNAKKAAAAHALKIMYERGRRNLEMCNEMAHKKLRTMTQEEVGSHAHRVVLVSRHVLDTAEETQFINYSKDKIAATFVLEYHGKMRVVGMGTGNRCILYQHMTLDGQRVIHSHAEIMARRAFLRYLYKQLLTYSGSRSHPIFTRSETGKLKVRDKIQVHLYISRPPCGDAAAFPTISNFPNKMRAIRKQGQLRTIIDDGEGAIPTDFPVPAGANGKERLRIMTCSDKICRWNVLVVQGALLSHFLDPIYINSLVIGSHTGDQRGHVPRAVSGRLKCGRLHEVIQRPFRINSPDIHYPHDDLADNYNITKSKQYCITWSYGDADAEILDAITGLTNMESLEEVVPSRVSKVCLFSLFREVCQRYGRSDLAALDYLRAKKSANTFQRMKSFVGQHLAAMGFGQWYSLQETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWU6</accession>
    <name>A0ABM1VWU6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 20A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826888.1">
        <property type="nucleotide sequence ID" value="XM_035970995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478059"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052666">
        <property type="entry name" value="CYP450_20A1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24280">
        <property type="entry name" value="CYTOCHROME P450 20A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24280:SF4">
        <property type="entry name" value="CYTOCHROME P450 20A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826888.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26964" checksum="8F740C0BC5164B18" modified="2025-10-08" version="1">MERQLTDSVPPDKNDTRQKSFQEALQYLHTMVKKVVEQRQQNKVQDQQLLIDVILQSTTDEDVLTSDVISYMVGAFHTTAYLLTWAMYFLATHPDVQNKLHSEIVQVLGQKDVITDSNYGQLRYPFIITPVIHAFGVVLQDEKLWPLPQKFDPGRFSAEHSKSQRTYAFSPFGFAGKRICPAYKFAYNESTVLIATLIRKFEVSMWGDQVVKPVFGFVTRPQEEIWLKVSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX19</accession>
    <name>A0ABM1VX19_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division control protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826961.1">
        <property type="nucleotide sequence ID" value="XM_035971068.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854349"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="56"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826961.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42793" checksum="E456348FFE009D1E" modified="2025-10-08" version="1">MVSLLIMQRRFRNLSIQKVAFALVIIVVAFNEFLVYSFQTFRWTRISKDRAPTEEMVVLFASDPQLIGVQDELGFPIGSIARWDSDRYLQKTFSRAYAHTQPDVIVFLGDIMDEGSKATEAEYQSYLQRFHSIFPETKITKTVIIPGDNDIGGEGRDFRTPFKVDRFEKHFENLTGVVKHGFIDFMKLDIRLNVDKVLETKRLISNLAPKLKEPLRIIINHETVMSKMKGTIYPILRMAQPNILFTGHWHVSEMFECGTCLSENEDIDHWPYNLRGLKNIKDFIEVDLTNLIGVNEILVPTCSYRMGEPNMGYGVAHIERSGRLRYTVLWLPARYTLLYIYVVALVIVSVLLLVSFVTAPRSKVRPPSSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXD8</accession>
    <name>A0ABM1VXD8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">EEF1A lysine and N-terminal methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11 12" type="primary">LOC101857267</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103862.1">
        <property type="nucleotide sequence ID" value="XM_005103805.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827078.1">
        <property type="nucleotide sequence ID" value="XM_035971185.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827079.1">
        <property type="nucleotide sequence ID" value="XM_035971186.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827080.1">
        <property type="nucleotide sequence ID" value="XM_035971187.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827081.1">
        <property type="nucleotide sequence ID" value="XM_035971188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857267"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF78">
        <property type="entry name" value="EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005103862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035827078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035827079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035827080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035827081.1"/>
        </source>
    </evidence>
    <sequence length="683" mass="77110" checksum="D91E6713D6E68FF8" modified="2025-10-08" version="1">MDLLPTSHTEFSQPDYWDRFFKKRGKIPFEWYGEYPQLSHVIHKYITPSNLVLVVGCGNSALSENMYDNGLQNLVNIDISDVVIRQMTDRHKVKRPKMTFEKVDVTQMAYTDMHFNAVLDKGTLDALLVSEEKDVIENIHRMFAEVCRCLKLGGRYVIISLLQDHVQRTLLRYFTELSWPIRIHRIHMEAEGGGQDSLSMPVFAVVITKLKSIPGMPQIVEVCRYEDRVDRLEDVKYLSEIVRDMQYYHIVRQQLAGKMSSDQQITLELHTPDSNMPRYSLTVVDSPDKMENKFAIFIVPQGRETEWLFSTDKGRLHLTASAGFQRLVVVGLGRGHEYDNLEAIKAELSLKVMELAPPKCPPRAQVPFLSIGEDIGRRFPVARGRSTVSGEYLVEDVELNGGQLYRRLIFLDNKNIIQSEARLKQPRKKKKRRQKGSTDVPSEGPPDKLRVDKGYLPSDYLIAFVGGLAFLPKLDSQISCLLVGLGGGGLPCFLHDAWTTMSIEAVELDPSVVEVARDFFDLVPDDSDRLRVTVADGLDVVRTLASQGEKRDVIIIDVDSKDNSVGLSCPPLAFVEKDFLEAIGSLLSPEGIFLLNLASRDEELGKSVLDRIALTFTSCGSLKLEEDVNTIVYAAHCTSSSPAWQRENLDAAWREMDAKIRKVWPDTNVELQDMMSGLTLPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W030</accession>
    <name>A0ABM1W030_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Amiloride-sensitive sodium channel subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101855760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828023.1">
        <property type="nucleotide sequence ID" value="XM_035972130.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855760"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035828023.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18493" checksum="776AB36D213C7D01" modified="2025-10-08" version="1">MSGKFHVDGPRSRKKRQVRNPADKSSIDIDWSALLQNSTFNKWDSLDSDINVTSKYYDSVDDELEAYLTYAYITAPMDPAVVEMAGHKKKDFIASCKFGGFQCSPRNFTYFHSHRYGNCYTFNHKDSDKVLFSKFSGPDLGTVIVISLFIASKPYRPLSFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2R2</accession>
    <name>A0ABM1W2R2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Ras-related protein Rab-9B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC101864345</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111036.1">
        <property type="nucleotide sequence ID" value="XM_005110979.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005111037.1">
        <property type="nucleotide sequence ID" value="XM_005110980.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828955.1">
        <property type="nucleotide sequence ID" value="XM_035973062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864345"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF1">
        <property type="entry name" value="RE17845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005111036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005111037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828955.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22987" checksum="73ED86CA88E65FA8" modified="2025-10-08" version="1">MSGRSKLLKVVLLGDGGVGKSSLMNRFVSNKFDAQSFHTIGVEFLNKDVVVDGENYTMQIWDTAGQERFKSLRTPFYRGADICMLTFAVDDRKSFENLPMWKREFLYYADIQEGTPFPFLVLGNKVDVPSRDVGEEAARSWCARNGNLPYFETSAKDSTNVDMAFKSAVGRLREMEDQMDEKPMHSANAVDLSKKAKSSNSGCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3E4</accession>
    <name>A0ABM1W3E4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829187.1">
        <property type="nucleotide sequence ID" value="XM_035973294.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478888"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829187.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="36536" checksum="723FF8FEE012D477" modified="2025-10-08" version="1">MVQEVDGIVHARRIKIRRDGKEICTNTWILTFNTPTPPTKLDIAYLELEVRPYIPKPMRCFNCQRFGHTLLRCRRGAACPRCGKEGHSGETCSADPWCPNCRQGGHSASSTECPKWCQEKAILTHRAQYGGTFAQARATLYPKGSTPKNTTKTYSEVLKTVPGSVNPTRKVLQTNRKQNTCKKHSSLETEEDMESTSSTPISPSLHPPSPHTPSSSPPSQPSSSSSPSSSSSPSFSSSPPSSSPTTSSPSSSSHKSPHPTPSLLQPPSHHPSSNKAPPPTPRTRSPSSTHIQDSGPPPPPHSPSKKAAVHHDRCKTKQRQRSPTTQKKCIEPVPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4P8</accession>
    <name>A0ABM1W4P8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B(0,+)-type amino acid transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106014116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035829641.1">
        <property type="nucleotide sequence ID" value="XM_035973748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014116"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829641.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35620" checksum="B1B2450A199ECE2D" modified="2025-10-08" version="1">MVAAVNCHSVALATRVQNFFTVAKLLAVLVIVVGGFYMMAKGHTEHIREGFDDTSRNPSTIALAFYDGLWAYDGWNNLNYATEELKNPYVNLPRAIMLGIPLVTVCYLLTNLSYLAVMSKEEIMLSHAVAVTWGDRMLGVMSWLIPVFVVASTFGSSNGCLFSSGRLTFSAGRDGHFPQFLSFLQIDRNTPMPAVYFTMAVSMCLIIPGDLSTLIDFFSFASWLFYGLTTTALLILRVTEPNMERPYKVPLPVPILVLVASIYLVVAPIIQNPGVQFVYAVIFILVGLVVYVPVVYLGVQLDFMVTVTKWLQKLMKIAPVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I1SKJ0</accession>
    <name>I1SKJ0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101854106</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2007-08" db="EMBL/GenBank/DDBJ databases">
            <title>Characterization of histones in Aplysia californica.</title>
            <authorList>
                <person name="Kohn A.B."/>
                <person name="Moroz L.L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="EU104712">
        <property type="protein sequence ID" value="ABW86953.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001267767.1">
        <property type="nucleotide sequence ID" value="NM_001280838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SKJ0"/>
    <dbReference type="SMR" id="I1SKJ0"/>
    <dbReference type="GeneID" id="101854106"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABW86953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="NP_001267767.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13407" checksum="04575D8E34905EE9" modified="2012-07-11" version="1">MPGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGSQKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA38</accession>
    <name>A0ABM0JA38_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cyclin-dependent kinase 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101847916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005088929.1">
        <property type="nucleotide sequence ID" value="XM_005088872.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847916"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07864">
        <property type="entry name" value="STKc_CDK12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="532"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="884"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1111"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1133"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005088929.1"/>
        </source>
    </evidence>
    <sequence length="1212" mass="135440" checksum="AFDE29AC41DEC15E" modified="2025-10-08" version="1">MPKSRKRNADPYDDEYDARAYSHLVPQGHGSSQQSHGSSYSNSKKRGKKKKSHRKRSKDRDDRPSVQKPLVDYDDISSDSDIVDLSPSANPSSSKTASSAVAGTSRSSSHSHSRSSNNHSSQGQSSGKRPVSPATAIRLYRDHRSRSKSRGRDDSPRSRTQQSRSKGSKKQKRSRYHSPDYNNGSSHQKDAKYNPPPKSHQATDQPKAYADLPKAYSAGYSSKEFGDRRNRSPSPYYKNDKRKRNSRSPSNRKSKNTSSGRGPASPSRYSKKQNRSPSPNRSHNRLSPSSSRISSYSSSKNRVSSRETFQFATSLASELIKKRKARENKNLNIAQDVCSVDSKTDSPDLEVISRSPTPVKNVHSVPKTDSSFRSDLPSSGPQTPQPPSRGNDSRHEDVVIQLENKPSETPPQKVVNERREGKPNGLESDQRHRNSQMSTLPQLPLPDLGPEDEMDLEQSPYNEIKKEKEPSRPRGIRDLPMPPVVDDPEPEEVELPPPKKEEAPKFRRPKLCHRRRYSDEQGDWSERCVDVFHILQIIGEGTYGQVYKAKDIALETLVALKKVRLENEKEGFPITAVREIKILRQLQHPNIVNLKEIVTDKQDALDFKKDRGSFYLVFEYMDHDLMGLLESGMVTLHEEHIASFMKQLLQGLQYCHRKHFLHRDIKCSNILLNNRGQIKLGDLGLARYYHAEDKDRLYTNKVITLWYRPPELLLGEERYGPAIDIWSLGCILGELFLKEPIFKAKEEYAQLDRISMTCGTPCPANWPEVIKLPLFHSLKPKKVHRRRLREEFSFMPKLALDLMDHMLELDPSRRCTADQGLTCPWLRDIDPNSIPPPNLPKDQDCHELWCKNRKKEMREQQQYKDEPPSKTSYQAWGAKPFPVAKPLPNAVPPDPKASSAVPKSNVAGDQKDLGKTSHTVPDIGNAKGDTKGPQNQLSKLIGILQTQQSITTDQIANSLGINVGPQTSMLLSNLKEQLMIAMSSVKKNPGMEKGDVLPSFASSIAAVQNVLSNSTASALSLDAHMQSKDYHEARSVGHSSISTSQFEERDGSLASEFAQATDSNADKHAGVKAALANLLSQQGIGVKIGGSKFDSSTSSKSNSPPGSQYSAQPMFTEQGSDNSSALNKQFDNSSFGSSSSRPPYPPGYYGDRSQGPGLKAFPEDSVPKQSQGASYYPYRERPGNAPGVPPQTRDPYDREYTGSGSFESRLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBQ3</accession>
    <name>A0ABM0JBQ3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="2">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089993.1">
        <property type="nucleotide sequence ID" value="XM_005089936.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860298"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="5">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="4">
        <location>
            <begin position="198"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005089993.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33624" checksum="39F8BCE1F4D81CF8" modified="2025-10-08" version="1">MSRVHLELCELLLKEYYGEQVAQVGTFLLKNIGSTLNSITQRTSLETKQVKSILCALVQQNIVRFRPLKPGITGYEASPDSVLWRLRFPSYIHCAKMLYGDAAELLVEELLLQGQSHLDTAVMKTTKKLNDSIVSSGASLPEISHNVIKEKVVTLVKARLIRRCEGVKKDENEKVVSLESHTDPNALFALPTAEDFRPATGSKRPQDAGPQGPAKRIKLESGAAVGTSDQEVPGTSSGPGYWCVNFHQFHHHFRDQAIIAAVSRNIDQRASEVMRTMLRLSETRTDPTFSESVHLSFTEVSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBY6</accession>
    <name>A0ABM0JBY6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Collagen alpha-1(I) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090149.2">
        <property type="nucleotide sequence ID" value="XM_005090092.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855841"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0176">Collagen</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005090149.2"/>
        </source>
    </evidence>
    <sequence length="656" mass="67125" checksum="D2D6B04C3AFCD1F1" modified="2025-10-08" version="1">MLGRTRKERWNLLQVRDPRGQPQFGVLLDGKRKTVELYFLNLSGRLERLVFNKKSRRLFNRDWHKLHFSVTRDNIEMYIDCKPITSQPLPPRRQIDLNGDILLGTKDDDGTTVPFELQWMLLDCDPSKPERETCDELPPKSARTTRRPRPTRRPRVDEQDPGGTSEGEGEDTGTGTSGGDPDGDNIGLGIDLSIDNGGDDQKEKTCEVTCPRGPPGFNGTQGPPGRAGSPGRPGRAGVPGESGREGAPGIPGRVGERGLPGRSGLPGQKGEPGLDGTPGPRGDNGFQGEPGPVGPEGRRGRDGVKGEPGERGLIGPPGPSGAASATVKGEPGDPGLQGLRGPPGDIGRTGLPGPRGPSGDDGKPGQKGESGSRGLRGFPGLSGPTGSRGGTGPQGPPGPPGIPGRGEESDNRIDQIVPGPPGPVGPPGPTGLLGPKGNNGDRGKRGYKGSKGDRGDPGAPGKQGQQGNTGSEGQRGRTGSAGEKGEQGSPGIVGPRGPQGPNGIPGLRGIKGETGGKGGRGERGYPGPPGPAGAVTSTNVGNSVTDNGTVTLLQGSPGPRGPPGSKGNSGPVGPAGMIGIPGADGTKNDFRGKVAPELPDVAGASLAEKWEQLFNWGASQLEVGKVPGKMRTCDRSAQHLLPQGPSGGNTLVSVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDN1</accession>
    <name>A0ABM0JDN1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Uncharacterized protein LOC101849348</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12 13" type="primary">LOC101849348</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091273.1">
        <property type="nucleotide sequence ID" value="XM_005091216.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091274.1">
        <property type="nucleotide sequence ID" value="XM_005091217.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091275.1">
        <property type="nucleotide sequence ID" value="XM_005091218.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091276.1">
        <property type="nucleotide sequence ID" value="XM_005091219.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091277.1">
        <property type="nucleotide sequence ID" value="XM_005091220.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849348"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF11">
        <property type="entry name" value="ALPHA-TYPE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005091273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005091274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005091275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005091276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005091277.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35879" checksum="C2734141ECA1D28B" modified="2025-10-08" version="1">MSLRVLHFQNETNASCPDLCGQGYKASFHNHSSAKGPRKKIYHGHLEGKGPRKGEHAAVKVFRDAAGTESKCDAEISKHKMARKIAKRFNKFVPDDHYQIKFTLPLKSTVDHLGVGFYLTPHKSRHVDKKEWVLIEENLLKQGEFQVFIRKTGERLGKDPTSLDAFLHYSYHESQGHHVMCGLQGVQTEKGYLLTTPCIHSVDSSFGSATDKGPKGIVEAFKFHKCNNLCYCFLRPDTAELETLGVKSSVSTDEERRTEEGETDEDAEDDGLIQFSYNTSMDAVEEKKDSVPEEDSLSEGNKKREDNAEMIEREGPQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE46</accession>
    <name>A0ABM0JE46_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101863876</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101863876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091610.1">
        <property type="nucleotide sequence ID" value="XM_005091553.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863876"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046215110" evidence="4">
        <location>
            <begin position="28"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="973"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1316"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005091610.1"/>
        </source>
    </evidence>
    <sequence length="1335" mass="143938" checksum="718E6AEBA76E5A7A" modified="2025-10-08" version="1">MATDCGTYCRSIAVLLLTIILFAKSSGEKRPKSSKKCPPGRFGPSCLSKCPNQCPTSCGEDGKCVDCLESGLKLPDCLSPCNKGFFGRNCKHRCTPACKDSDCSVKTGNCLECRAPGLALPKCSSLCPKGTYGAQCSRRCPLTCEDTCDPLDGHCTDCSHGVGAKCAVNCADRREAAICKLYCPSNCVGWCNSTDGQCNVCASGLKPPFCNETCDEGYYGRSCQKKCPVRCKNGTCDPVNGVCVGCLAGYVGKRCNGQCIAGLYGELCSLSCPETCVDKMCHFRNGSCLLCLPGYTGPLCDQFCPGGSFGPGCNLQCPENCGGVCDPMSGWCWKCKPGYRGPFCNATCDEGSFGEQCTNRCSEFCVREKCHHLSGACLQCGPRRTGTFCNEITSEPKANQFKMAVFIFLGLLSPVGLASLSMAVYKYKIKKVRDTINHRNRNLVTASVAKDRGAKPSPGLSGAHKDPKTSPKFPLNQEVNYKDAVFRNRALQFPKYFPKSPVYSNASKKIDIQREHSSARCTPINNEPVTSAGLGPLGANTSEPYTSSLENLRSAEGSRFSPSSHQTLEHRQELSCAVHRHKLDGISRRQWSAQSKNVESGRAITQTNDTKTYQLDTSSSYEFFTILKASYKEKNHTCQGEASGLATESTSNVSVRQNDPQTSGILSLSPISLSGNTSSQLEHSENKLVFSYSTSQKVDISSKPKVPSPHTITATSHTLISKVQGATSRSDTLESLDSNLDVQSACFVEDKYSMPSFSKGGEPAKGTSKDAGQTSSSLSGQTDPTESLVTSESKRDLYPVAYSPESSYANQRIISESELKNRRQHATSGALGADAKDSEQKNTTVADVLHQRPSKPHYIDPEAIPLHSVPSSEIVPNLTGEIEILQRHVSTLISPGPIQRTLNTEYAHLNGAAHGEIIRYNESSLVTNRGRDLDPGPATQARNPFGRKPLSRPASGPNLRTVSRLEMGVFSQSSPLGANTSDPFTSSLENVGSADGSRFSPVRQMLEHGQELSHEEQHDQQDRTTYRGVTSDTSARPHKRATKDKQKNNGHASELTFTEQTTKSLSKFAGASRSHTDERPRVGPPVPGRKMSFSSKFKSEKDIQNSVERTSSTAFSRPQTPAKMYVVHKCSPPRSIEDLSHIKRDRMSPSKRSLQNNHGSPSKQFSAANTSPFKRVSIPPSPKMQMPVGSSSATVSDTHPTLVSAKTSERDIIVSGTSFRSTDQLTHSPTSTIPATSTSHQPTPRSNSNIRNAEVAAATFCKGGTAKVLRCPTTRQLSPMYPSQTKSPDVAAPKPLPTPPPGGRKSLHRVGRAADASTSHGSTSTNTDNSGLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEF1</accession>
    <name>A0ABM0JEF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101854067</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101854067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091819.1">
        <property type="nucleotide sequence ID" value="XM_005091762.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854067"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005091819.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25543" checksum="C9B66FCF1E9BDA2D" modified="2025-10-08" version="1">MSFPARKIRTVNTTSRSTLKPTVRDFSDQVIGNYTIDDDTLCVSTVARAQSEISTYRRPHSTVTYTSLETAAQSHIPATFDTPRSSTFGPAEVHRRHVVKSARLRSRLSGNKQMKRLDSRNSVLSNGWQDTNPGFFATYPSGSCRDLVSSRPFERSVSSEFIGHQHPRVRPSTTGRYFDSSNGLWTSSTARMSYQNRPHTAGAWAGPGLRIQKMTLNVKDSPWVHGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEG0</accession>
    <name>A0ABM0JEG0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101863080</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101863080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091866.1">
        <property type="nucleotide sequence ID" value="XM_005091809.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863080"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005091866.1"/>
        </source>
    </evidence>
    <sequence length="691" mass="79349" checksum="D83FD8C11C21AE0E" modified="2025-10-08" version="1">MSSLQILCCQAISFEIGKFPESILEDLNQPCLCLLVQHLCLIDLLKLSPFLKARDIPTEAVVNNVQRLQFKHVDAYPIKDATCPHLLNLFPRDSWDWALSRLLYRRLIVRMVEERSQCYKEGTVPSASELWNGIPDKHTDVFELFCPPSLTICPRVKEKILERWSQRMEQSLQIAAENIYYIIVDLSVCQLLMDCAYKHVLEKFCKSLKALSLLIKSSLEIVDFVRKMKERATHLERICIFAIKDEDMEYFDSILSVCSGVRNFYSTAEGQKMMKSVDALLSPTNEMKDCHRQDEDSTTESEEVDKPDFDLMDDAVLFSTPNQPSDDDSSSGMCKADFKVTNLVTKRLYVSVLSHHLDHWLALRELHLGVPELQPKITASVCSLIQRPQFKSFTLSSTDFKVNEIEEILVAVALYRKSSPMEKLMFVSVVTKWENVEDINLQDQLPGENDEAIDAFLAQYESQRLSKFSEFRGTNLLEWYSCSLGLRTECLIRQYLTKDRALTRVCFSNSLTRRFLTITLKTVTSLRMPLNQVIIEDWRVLSTEDCQILVGFLRSVSSTLESLNLSNCVLMRGYYSISDVWDALCECKKLKCLDLSANRLGDDLLPLVPKLMCQTDLRELSVRRNNMSNATTVRFLKNFSSLALPRGRMLDILDLRGNQFSEEDRRKNPGLLQDVAKYILLSSSQIEFMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JER5</accession>
    <name>A0ABM0JER5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101847244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101847244</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092055.1">
        <property type="nucleotide sequence ID" value="XM_005091998.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847244"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045821338" evidence="7">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="210"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005092055.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30373" checksum="E135B48C24F34F09" modified="2025-10-08" version="1">MHLFVYVAVLLACLSMVVAQRNYGNNYGRNQQGQQQGQFSYQESNPPRQNRPAQNYNTDDTFGADPGCRDPWTTEWTRDPNDCTQVHFCVQGKKYWTINCNDTRVWSNVGHACVEPMSQWDDCNQVMTTPALNDPRCAPDPNGMNPDPSNCAQFLACVNMTVVATMDCPTNTLFSTRNSTCELSFLVASECRERSIPGHVVVTTASPIVDKPCAGFSNADVSDPTNCARFYKCNYGRVVARIKCPNSSAFNAEKRKCDWRANVDCQDRPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JES3</accession>
    <name>A0ABM0JES3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 177 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092070.1">
        <property type="nucleotide sequence ID" value="XM_005092013.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850141"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029090">
        <property type="entry name" value="DUF4659"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33663">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33663:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15558">
        <property type="entry name" value="DUF4659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="416"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005092070.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="71445" checksum="7EF5719FAF652EE8" modified="2025-10-08" version="1">MEPELGLHIDLYNLEDVKFEGSKYVLTSPRSLEACSRLDVKPIELLYKPLSEFQEELLPQDIPLRTIYTLYDESEEIRQKKLRLCREERKRILESELKKESTLSRDIKLSTLPSEDALAKQKKQKSALSPTKAVGFRSSYASRILKKSADRESTKLHRELVSKKEKNPPRARSTIRTRPQSADRRRPQRCAPSVTKGSRVRVRSGSAPNARLPVRDQKILKLMKDRRDEERKDLQASTEARRLWEDQKKREEALRTIAENKRRQLLAEENRIRDRRKFEEKERIIQAEEEERELKRLAVKDSQLNAEIALMNQLRMKELQLSDKIQKETAKAEIHELNLKAKEKEDEEIRQLLLAKQITDVNSATERKDVRLHQESLKKFLDNRQERELHEKRKHFIENQERQNQAVMQSSMASRLNQAESNLSVVLEQRNKQLEEQRRAEQEKLHRARKAHRRMEAEMDAWRHGLLEHKKMMESRASEVVNKSLELKSWQVKKDRMNRQTEQKRNISKIHKEVERWRSDLEKSLCERDRKVEDLLEEKERTISETRAMAQISQTMRDDIKERYVSDTFDKKALEAQLYANLYSSHRSRSPSLKNRSSIKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGA2</accession>
    <name>A0ABM0JGA2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093032.1">
        <property type="nucleotide sequence ID" value="XM_005092975.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854004"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF478">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005093032.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31091" checksum="5494C93A96F5610E" modified="2025-10-08" version="1">MDKLSLDKILRQPEASLDKMGKQKTSFSIVKYIFFGFNIFLWLLGCGVLAVAIWLWGTRGTSVSVIPTYSFLSASSLCIIASVIILVIGFMGCCGAFLENQCLLIGYFVLVLLVFALEITAGTLGFVMKDRVHKIIHSEMTGGIRYDYRTEVQIETADHNNTLVDRDSKGWSTMLDLVQKDLGCCGVDNHTDWYYVQAWPNEQRVPESCCIRPTKDCGIGGSDLWYDRGCIEEVEYWFTRNMYVLGVTGVTVGSVQILAMVAAIAQFCYIRSKRFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGN1</accession>
    <name>A0ABM0JGN1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline-rich protein 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093273.1">
        <property type="nucleotide sequence ID" value="XM_005093216.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848730"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058599">
        <property type="entry name" value="PHAT_Smg/ZCCHC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042344">
        <property type="entry name" value="ZCCHC14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16195">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16195:SF16">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26034">
        <property type="entry name" value="PHAT_SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="1142"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="846"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="892"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="928"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005093273.1"/>
        </source>
    </evidence>
    <sequence length="1178" mass="126363" checksum="56555FC554ECF1C9" modified="2025-10-08" version="1">MVRKEDLCDWFKNLQAPKRLDYMCGLLHMCLPLELRFVGSVLEDLAKKDFHFLRDKEIKANSPQDLSSNESSSLADSNLRGKFLIALALMNSANVQCADIIYSILKTAESHFESLAGSILLDKKAAEEIELILTMAVHHPAFKMRQKLYLGDIQKLVQRRIYELHGSHEERELLLPPHGSLPGHVPVYPSQTSPVPQQSERVLLKSLEIKGIREEPKSRKDGPEFQIQTVWSNGEIMEVYMKFKQLQDLHQKLLYKFPEEKKQHKSIPVFPGKQSFRNEADKEKINSLNSYFRELVKAPSHILNCDVLLEPLRRGSLVQPTSNPPQSCIIMPRSFYEENGWIPQYTVPPYARLPLCSNPSSPGQLTSPSQVSSCAESPANSRTSSPALAPHHASGVCRTNLTSPGARAKGPHIPLAGGSPNVADSELGSNVELSLSQLLRLLGLEKYFDCLRSYSFKQILSMSKDDFAAAGLPADAQDKLRSKLDQYNQSQLDNGHIDTTSGSSSAEISPSFPYSVVPIHRMPFIASPQYGHTYVQFAHSQQPSQASLLASPNSHTTGEESSSANSEVSSPPASPSQINLAAQSVDLPQVPPIMTLAAAQVSPGSDGAPLAMMAPPAAVAASSISPSDVKLLRSKNSNPPDSSGSEEDMVSGYDQSDSSVGRSRGLGRPQQSFSQTGMSGTGNPSLVVDEGKVVVLPISMSGPSSHIHSALVSVEASNEHTPPPNVAIPVVCASSQISTSAAAAAALVNGYMSDPPPPLIPQGPVMPRSILNARPFKSAQPTHTAPGMHKNVVNMPNFDHMGHLPQAVGKGPGVLPSGMHSIPHHSFMAPPVVSTATSNQGLVLGPGSHQSNNNNVLPQPPPQHPPHMSGLASECAPASSFHSYPLIMRPPNLPGSLPPQRSILTSVASSSSAMTSSQCHSAGPPLSHSPSPVAATTSNDQVPTYLQGSDMSDPRCMDRASTGTPPSQTPPHLVSKPTVTASTSGTNTPSPPLNQPLGAVVPPQKQHSANCLNCDPAVSSGSGGHPVYFHHQLGHYWYHGVMPAHNHPSNGLVTAMPPFFPQPQASQPFPNGMNPELYMAAAARFPAQLAQGQLPPFLYGNSYPTHNQVMPQSNLQTNAPPPVNASLGHGPPNNGATNKIACYNCGNTGHKVAECKESTMENMSKTYRLNFKPKSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHF2</accession>
    <name>A0ABM0JHF2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="11">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101850544</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for normal Golgi function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Golgi apparatus membrane</location>
            <topology evidence="2 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093725.1">
        <property type="nucleotide sequence ID" value="XM_005093668.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850544"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="43"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="188"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005093725.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="71336" checksum="1D6C773532FE6D47" modified="2025-10-08" version="1">MADKDGAEPVTASTNNPLSRKLNKILETRLDNDKDMLEALKALSTFFTENSLRSRRNLRSDIEKRSLAINEEFLTAFQAVKEQLDSVYSDVQAMNECCLDMTSRLKAAKAKTHHLISQTTSLHHESQRLQVKEQVANAFLDKFQLKQDEMKSLRGSKDGTLHVDFFKALARVKQIHSDCKFLLRTNHQTAGLEIMESMALHQESAYERLYRWTQNQCRLVTQDTPDVSPMLCQAVEALQDRPVLLKYSLDEFGKARRSSVVRGFIDALTRGGPGGTPRPIELHSHDPLRYVGDMLAWLHQASASEKEYLQSLLKGCTASNIQMDEVLGNITEGVCTPFKVRVEQVLVSEQDPVTLYKLDNLLKFYHHTIGQIVNTEAALLSTVAEIQDLSHRMFFNSLTGHANRLLDKVELPPSDLGPTSSLTQTLQLLRDVLACHDASVVPIDDKKQDYKQILACVIDPLLQMCSMSASRLSAIDMAAYMVNCIHLMNTTLALYEFTDTRLEMLNAQTDAHVDTLISEQASYILNRVGLAQMYGAIQQHQTGQGPLSSLPGLDELAIKSAVNKFDSYLAQPDSLTLPQCSLILGVTVRETAKKRSVELVCEAYKQIFNAILDPENGYKDGKSIVPRTPDQVTHLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHG1</accession>
    <name>A0ABM0JHG1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101855239</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="14"/>
    <dbReference type="RefSeq" id="XP_005093745.2">
        <property type="nucleotide sequence ID" value="XM_005093688.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855239"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="712"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="16">
        <location>
            <begin position="550"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Plasma membrane calcium transporting P-type ATPase C-terminal" evidence="17">
        <location>
            <begin position="770"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="822"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005093745.2"/>
        </source>
    </evidence>
    <sequence length="855" mass="94603" checksum="769A4A9002FB5794" modified="2025-10-08" version="1">MVEGADEAKAKSGGSRKEKSVLQSKLTRLAIQIGYAGTAIAVLTVIILIVQFCIREFVIKGKSWTADDTTRNIEMFVKYFIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMHDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYIGQQHNRNIPNFSNFNKFLGQLILESISINSGYTSRIEPGENEGELPKQLGNKTECALLGFIQAMGESYDQVREKYTEESLFKVYTFNSDRKSMSTVIKVDGSEDRYRFFCKGASEVVVKKCDYILDSEGKAVRFNLQAQEKVVHETIEPMASEGLRTICMAYKDFVSGTTEMNESSIDGVDWDDEAKIMTGLTCVAIVGIEDPVRDEVPEAIRKCQGAGIMVRMVTGDNVNTARSIASKCGILRPGEEGLVLEGKEFNRRVRDHTGEVNQEYMDKIWPDLRVLARSSPQDKYVLVKGIIDSKSESTRQVVAVTGDGTNDGPALKKADVGFAMGISGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVLAAFFGACIINDSPLKAIQMLWVNLIMDTLASLALATELPTDELLKRKPYGRSKPLVSRTMAKNILLHSVYQLTVIGVLLFKGPDILGIDDGIQDVENVHAPPTAHFTMIFNSFVMMTLFNEINARKIHNQHNISEGLLRNPIFIGIWVGTIIAQALIIQFGGIAFHTTSLNASQWLWCLFLGVGTLLWGQLVTMVPDHYMPSLRWCKRSKKDEDEDEEDGDHVADDPVSGRGQILWVRGLTRLQQQIRVINAFRMSVDTRYDNRSLTSMQSYHSVQNIRAARRPHFQSSTEMSEPPGATGLISSATAPGRVAETTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKD0</accession>
    <name>A0ABM0JKD0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase omega</fullName>
            <shortName evidence="5">GSTO</shortName>
            <ecNumber evidence="5">1.20.4.2</ecNumber>
            <ecNumber evidence="5">1.8.5.1</ecNumber>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Monomethylarsonic acid reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101855415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:15969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:33409"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.20.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.2" evidence="5"/>
    <dbReference type="EC" id="1.8.5.1" evidence="5"/>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005095748.1">
        <property type="nucleotide sequence ID" value="XM_005095691.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855415"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="89"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005095748.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27223" checksum="4A3428AF0E65FA88" modified="2025-10-08" version="1">MSSLSKVQLYCAWFCPFAQRAWIALNEKQVDYEYIETDPYNKTPEFLSVCPRGLVPSVVHNGKPIYESIVLVEYIDEVWKKEVNLLPDDPYDRAMAKIWVDFISKKIVPVFYAILQKQDKAGQETAKEAFMKNLETLTGAMSKQGPYFFGANFGFVDIMLVPYTFRLRLLAHYRGLEVPTNGVFERLQTWMKAAHSRESVKSTLPEWERLVAVYQRYADNTAKTEVAEAIRAGTALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKQ7</accession>
    <name>A0ABM0JKQ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC101858550</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101858550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096005.1">
        <property type="nucleotide sequence ID" value="XM_005095948.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858550"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="46"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="237"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005096005.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44107" checksum="BFAEA6098987BDE8" modified="2025-10-08" version="1">MPPNVSDWWEGGGGHARGFLDAALVQWFELVVTVGFTQVLCVVGVGSNLLNFVVFWRQGFAESVNVSLCALAFSDLCGLLTLQVANVCAYPWLDREWGVPVVPRELMYLAGGWPHLCFARISSWIMAYVTLERCLCIVVPLHVKRLVTPGVTLTVVVVIHVALVGSILSEYATLYLDWVWQPASNASLLRLVSRPTRAGVEGVAHLVSFLTQFLAFVAVVVFTLVLLVKLRETREKRDKMTRGRAATREGNRRDKAGDNSSGASAAPTASDKHVSVPQADNSGHGSGGGGGGGGGGGSGGKRERKTEKMVVLLSCVFIACFTPSTVAFLFVMLYHEFSVYGRYRNTWLLVWSGCFALEALNANVNLPLYYHMSSRFQNTLRKMFPRLLARSTPPEKQMFKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLD2</accession>
    <name>A0ABM0JLD2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable receptor-like protein kinase At5g20050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096430.1">
        <property type="nucleotide sequence ID" value="XM_005096373.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856728"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005096430.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33449" checksum="4E743C81BDBD0B7B" modified="2025-10-08" version="1">MLGSRAQILKETFLDSMFYLLGMNLKAMRNVVGAVTLLRMKHARKCSSNITDLETITYNNFSTTRQISSMATLTFPDVTVIRDGDFLNNFNLKFVRVLAKKKNSLVLEASMKNDDSIRKAIKKIPYLDSKGRHRGLEDSTEELTIMHNVQHPHLMKMDWVVTDLWMDCVSRSNGTKWNGFSYKPPVPFDISTTSAVYTGTRVKPDNIFQDASGNAILGDFGCSQILPDGENTVSRWRGTLGYHGPEFFLGYKFDPFLMDAYALGATLWSLVFRLKPADLDLLDVVRNSSLPEMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMG6</accession>
    <name>A0ABM0JMG6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Brefeldin A-inhibited guanine nucleotide-exchange protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097140.2">
        <property type="nucleotide sequence ID" value="XM_005097083.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864061"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097140.2"/>
        </source>
    </evidence>
    <sequence length="194" mass="21725" checksum="16C7899EE1A894BD" modified="2025-10-08" version="1">MSSQSHNMEDVLRQLSRDIITPKFASIKQTANEALELLQNEEKIKTIEAWELREICLQPLQLALESRAKKLGHTALAGIQVMFKDERFRSSIETNEEDKWLPSQVLTVLAITPNLAEDLQVEVIKLLLNMTVTASWCTSANTIIKISQKKSITTHRLHGQLPQLRDGAGGSAGCYGHHDQQVRGRPHREGGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMI8</accession>
    <name>A0ABM0JMI8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low density lipoprotein receptor adapter protein 1-A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097173.1">
        <property type="nucleotide sequence ID" value="XM_005097116.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851346"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13159">
        <property type="entry name" value="PTB_LDLRAP-mammal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF74">
        <property type="entry name" value="PTB DOMAIN-CONTAINING ADAPTER PROTEIN CED-6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="40"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097173.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35049" checksum="999A785F94347841" modified="2025-10-08" version="1">MDALFRAVRKSPNVFHKDQGKSKRSKIPEGWGENKEPVEDGVTFYLKYIGSTLVEEIESDETYGDGISAKAVHNVIALAKSAGNKLKKTALTVSPRGISMVDMMTNQVMFDISIYRISFCTADKTHDKVFAYIARNTTNETMECYAFLCPKTKIAQAVTLTVSQAFSIAQDRWIEKKKFKKSLRDKTRKDGIHKKSSQSQSSPQSSSVINSSQPLLISSPPPGSNSTGTVLSSPSKQQVERADSRKNWESFDDNDSDDIDDMFSQLAENRSKQLPTFGTDLKEDELDDGVEKYMGGSACYEAFARTKSVEDLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQM0</accession>
    <name>A0ABM0JQM0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101855494</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005099249.1">
        <property type="nucleotide sequence ID" value="XM_005099192.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855494"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF286">
        <property type="entry name" value="GH22266P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="752"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="680"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005099249.1"/>
        </source>
    </evidence>
    <sequence length="867" mass="94959" checksum="AF0DF30BFA72CDA3" modified="2025-10-08" version="1">MDKRRPPQSAQQSCNNNDNKNNDPVSKANDDNDKNDDDDGYDSTTVSADAKKIPKRNDRNSSNSSNSSNGYSDGANTRNQQEGGYGWVIVIASFFNAFIIDGTGSCFGLLFPYIVEKYESSAFVASFAGSLFVALMIMGTVSAELVRRFGFRSVSMLGGVLSCVAFVASVFSPNIIVFILTYGLMAGCSCGLVFVPSIVIVNGYFHEKRGLANGIITSGSGAGLLCLAPFINFLLERYHLEGTVLILAGILLNMCVFSSLYRPPSLGTSHKTGEQGGRKDGCWSEQRELQSHSKEGSNRWFGDEGVESWETDFADICEISLTASNESLPYAQSKTSVDGSKYDDRPAQESSIHEKKPKSALQYLQYRLFAKSRSDHASLFPHLQFGSQKKLERTGKGTERVQWKSAHQLQGDDHLQPSSNPQVSDRLHRSAHNLPTWTTDKEHDSAPRGKQQYLLSTNHGTSEHSHHHSHRPHSQSHLLPPDHGSNLYLAGSISTLKSLHNKHLHSLHASQSSALHVDHHHHSSSRIPKDNCDDEQPSDLLVLGNSTTENSLHLPPKLKTSHNYIHNTHSPFQSVSNVSAKDHSIGALPNGKPNESVLQEHLLNNSDKHAPQNKSQQIMPPILILSPTGHQGSNSYLNIPSYHKSTENVDIIETCPAFPDVDESLPFSGYTTRQLLSMPAFHIFCFGASLIQFGYPIAGTFLADYAYQYGLSSSHTAILMVLLGSSNIFGRLLAGSLANLGLDPLRLNNMSLVLGGLACLLSPLYTQFWSLCVLASLFGFFLGFFPPLQPLILVEYFGLDSLVSAFGFLTTIKGLANIVGAPIAGRIYDASGNYAYSFVFAGACFLTSALVHWLMTLARPQLSIRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQR7</accession>
    <name>A0ABM0JQR7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099334.1">
        <property type="nucleotide sequence ID" value="XM_005099277.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855873"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099334.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21367" checksum="A28D214B2393BB89" modified="2025-10-08" version="1">MFGLVKSLVKGLQKPEYELDQQAENPVNYEVRKYKATKWVCTTVKSISRKDATSEGFGRLFKYIQGNNEEKATVEMTAPVTTTIVPGEGPNCESTFTVAFYLPSEHQVNPPKPSSPDVFFEDRPEQTIYVRSFGGFANDEKWIAEGLALTEAIGDESKFESSYYFTAGYDPPFKLIGRTNEVWFVKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQY2</accession>
    <name>A0ABM0JQY2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Golgi reassembly-stacking protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101864228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GORASP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099461.1">
        <property type="nucleotide sequence ID" value="XM_005099404.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864228"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="111"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005099461.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="42835" checksum="9AC8615107410F7A" modified="2025-10-08" version="1">MGGSASTEVPGGGTEGYHVLRVQDGSPGHKAGLEAFFDFIVAIGNTRLNQDNDTLKELLKANIEKPLKVTVYSSKTQNVRDISLIPSHNWGGQGLLGVSIRFCSFEGANENVWHILEVQPNSPADLAGLKSDSDFVIGADSVLHESEDLFTLIESHEGKALKLYVYNTDSDSCREVTITPNGGWGGQGSLGCNIGYGYLHRIPKRQFPSGKGQVLNNAVIPTAPPPSPPRDGFSEVPLSSSPPQVSSITPGVAQMSINAGSPTIPVIPPQSATSQIPGTDLPPPAALPNLTNLPGLTTPISLPGLPPVSLPPLTASGPLGPLPPLTAGMPQLPMSLPAPAPLPAFPSPLPAGFTAPVPGAVPAVSAGVVPPTLPAAPPAAVAGNGPSALGQIDVSAMAAAAVTNNASASSSPPPPPVAGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR67</accession>
    <name>A0ABM0JR67_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101860102</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099614.1">
        <property type="nucleotide sequence ID" value="XM_005099557.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860102"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005099614.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14588" checksum="F29A82D2BA614E14" modified="2025-10-08" version="1">MAAEKKEFRLSEVKAHNDAKSTYLVIHNKVYDVTRFLEEHPGGEEVLLEQAGGDSTEAFEDVGHSTDARDLMKDYYVGEVHPDDRSTKSYATNTGPTSYDSASSSSSWTGWLLPVGVALAAAFAYRYISSQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRG9</accession>
    <name>A0ABM0JRG9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clumping factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099830.1">
        <property type="nucleotide sequence ID" value="XM_005099773.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854575"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF328">
        <property type="entry name" value="TISSUE FACTOR PATHWAY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005099830.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="36901" checksum="AB522ED1160BB3E2" modified="2025-10-08" version="1">MCRAFTIQYVYDVSSGQCIEMTYGGCGASENSFTTLQECQQTCEKPCNKPQVAGPCRANLPHYYFDRGTLSCQLFDYGGCEGNGNNFETSEECEAHCGGIRDRILSLDPSRGKAFKDSVTKCGTGGGSKDGCTEDVHSNSKGTDGETKDVDVKSGDSDSKSEDSDSKSKDNDNKSGDSDSKSDDSDSKSEDSDGKSEDSDSKSGDSDSKSEDSDSKSKDNDSKSGDSDSKSDDSDSKSEDNDSKSSEDKDGNGKDRGGDIKNGDLAGNGGAKNGNREQETTQTPETTQVPTARGQPNQPGNNGEEPDVAFGNLMKYRPKKLFDSFNFAAHILFRPNKKPKQNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSE3</accession>
    <name>A0ABM0JSE3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM184A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101856434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100439.2">
        <property type="nucleotide sequence ID" value="XM_005100382.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856434"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039478">
        <property type="entry name" value="FAM184A/B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15665">
        <property type="entry name" value="FAM184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein FAM184A/B N-terminal" evidence="4">
        <location>
            <begin position="48"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="56"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="776"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="867"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="957"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005100439.2"/>
        </source>
    </evidence>
    <sequence length="1098" mass="126827" checksum="AE7206E18E934944" modified="2025-10-08" version="1">MASGAKMSYNHFQSGKFGGLPQASQKDAEVTQDMHLKMSKKIAQLTKVIYALNTKNDENETVLQALREQHEEEIQQILADTKQKVAVYKDRLDEESDHQATIEALQTRIAEHQSQQAAIEEQFSQYKINIREKQEKEREDYAAKLFDMSHEVLKAKKDFEDHIDKFNSWKERINAQHSTAVAELGSKHQREMEDLRSFQRNQDDTWLNQCAQIEEKFKDQIESLKSQIEAMEAEKVSLNEEYTAKLEKAKAFYEKELEALRLNQTQEHSVEVEGLKKEIDRLKGDFGANDKELRVQIDRLVRQLADTEDSLEASRKEQQILQAELAGRNSSSSELAKQLEDLREQLASQSSKLHSTETELAGSKQHVADLADELSKKSTLLGELEAHNMQKESIISSLRDELEKLRQQLTRVDAERTSLLSQQQSSSSEQKSQLQSLRQALEDMTVEKETQKQRFEKQIKSLQDELEKTEKSLKEEMALKLSEMEKSHVEARESDRKCAAEVLTATKQELKENHEKEMSQAKSDYEALQQEFEQVKADLKSRLAAAEEELRRMEQMIKQSEEGLGSASGQLKSMKEAAEHLRTELEKTRSELKFSKTTAASLQSELDKAKLMYEGKMTEMDMRLKTKVEEVSQEMEAKWKETMKSESSKLRQELTSQMENEKRAALSQLSQLKDQEIAAVRAGLDSQMEHLRRQIQELQTSLEQSKSLGDEQKAKWEHQLEREQSRLSKEMLEAANDYAVKIAAMEKMHAGELERLEAQKDQEKLDQEKTLHTKHLEELQGQMAAHRAALDNASQLEKRQRQEALDELKGRHAQEMEELRSQLELQKQLDIDTIKKNHAAEISAARMELDRAVEISRQKDRDHQMQMEELRTEIGHREQHIKNLQEQLRALQAEINRLKQEIDSKLMEIKQVHKQASQQLRVQEDKLTKQQQQALDNMSADHLREQQEMLGQFTAAQEMLKDKISALQIELHEAQTRYEQRESRPDDLELIESLRCEVSERETRIKDLIDEKRFYQLELVNRETNFNKVFNSSPNVGVLNPFSKPKKKGEKGPSLTMGAAGSGSHQRLDPLPGSPLHDGKLNPTKPLPQPNFTKKFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUB8</accession>
    <name>A0ABM0JUB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC101848210 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101848210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101675.1">
        <property type="nucleotide sequence ID" value="XM_005101618.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101676.1">
        <property type="nucleotide sequence ID" value="XM_005101619.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848210"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021113" evidence="1">
        <location>
            <begin position="29"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="135"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101676.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23488" checksum="7A6F76B1D9E70F14" modified="2025-10-08" version="1">MTSHTADRTVFYIAVLFAFSFFLTVCKGQDRCQGLENELRRLPGEVKTSCIVEYQRCERGLWRNARCEAGVIDFSLKYCTPFNTSCPATARLAELRAQGTIERKKREAFTEMYISKAETRASRYKRQTTVDCAYSYTCPSDLTMLTIYPDWTQCEKYIVCLAGELIRTTCKPDYNYYNPSRLSCEEYASRTNICVWRGRTLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUG6</accession>
    <name>A0ABM0JUG6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005101773.1">
        <property type="nucleotide sequence ID" value="XM_005101716.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850574"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101773.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20657" checksum="FD1BA0512578A897" modified="2025-10-08" version="1">MGVFQYFSYGSNLLRERILISNPTAKFRCVGRLNNYALQFDTPRFPGKPRWHGAPATIEEKDGSYVMGCVWEINEAHTSNLDAQEALYHPIFVDVDLETGENVKCRSYQMNNDRTGDTLPSPFYIKVMIDGAKQNNMPAEYINFLENVPTNGIKEPPPVYLTVMDMIEKFRKSAKENGTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV57</accession>
    <name>A0ABM0JV57_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead box protein B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101861899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005102249.1">
        <property type="nucleotide sequence ID" value="XM_005102192.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861899"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF387">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005102249.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="49627" checksum="77FC4BC53FA0BAD4" modified="2025-10-08" version="1">MIMNMEGGHSGEQYLPARGQHGSPACMLTSTPVGVAPPGMYGAMSGHHAGMELQSLGYPNTPAKVNDSTGTLGSVSPRSDDSNPNNEETSSEALSGDIKKHVLGGGGGAGSCLDGGDTSEEGMSEEQAKMYSGTSTLSQQARRFADVKPPYSYIALITMAIESSHSGMMTLNEIYSFIMNRFPYFKENQQRWQNSIRHNLSLNDCFVKIARAPGRPGKGNYWALHPACGDMFGNGSFLRRAKRFKLTRPKSENSSHIQHVNSYSHFNMYGPHTGGYKPYPSFNPLAFGSLSHGLSQAQQYALQHKPQDAWGSAPSYASYYNNSGMAPTQGLATPPPPLGASSTTGSSFQSSGLSSHHLGSSSLASSHLTGSAHLGSSPHIGTSLPSLGGASLGGSYSSSHFSAPTLGASGFSSSTLTAPPPHLGSSYHLPVSMAPQVPSPGPSSNGLPSSYPALSQNPYNCSQYAPQPPLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVV8</accession>
    <name>A0ABM0JVV8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101848444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:75539"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes glycerol monoesters of long-chain fatty acids.</text>
            <dbReference type="EC" id="3.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005102729.1">
        <property type="nucleotide sequence ID" value="XM_005102672.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848444"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="83"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005102729.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39596" checksum="9623915BF3115CE4" modified="2025-10-08" version="1">MDLVDLVYPELTLMNPAALTVVTVTAMMSLYVYFMQPSMILQAYFRVAVRWSGMKIRCTKLLPDGFRFFYGEKGQKTKGQMSVVFLHGFTADHFMWAPIVQNIPSSIHVIAVDLPGHGFTMDPLDNDDIGFRAQVTRIKQFLDLIDLTEPVHLVGISMGGALAGLFAAEFPDLVGALSLTCPSMKTPEESHMIKSNKERVLQAGELTIENCPMLPQTSRQVQEMLNISHYFSVSYPSQILKGVAELRKRKNDFYLRLVREIISEPSQVMLESSLSKISSPTQVIWGQEDWIVDVSGVDVLRKHLPNCRRVNIMPKCGHAVNLDQPAQFAQIVLDFWRDQQSRMLPEGKKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZA9</accession>
    <name>A0ABM0JZA9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable RNA-binding protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005105065.1">
        <property type="nucleotide sequence ID" value="XM_005105008.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857507"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12318">
        <property type="entry name" value="RRM5_RBM19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12571">
        <property type="entry name" value="RRM6_RBM19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034423">
        <property type="entry name" value="RBM19_RRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034421">
        <property type="entry name" value="RBM19_RRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="430"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="569"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="671"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005105065.1"/>
        </source>
    </evidence>
    <sequence length="785" mass="87795" checksum="7BA9F70B4AA8C558" modified="2025-10-08" version="1">MSSRIIIKSLPRDITRDKLVSHVQKICPGVEVTDCNLKYTRDGVFRKFAFVGFNSSQDATTTCRKLNGTFITTTKIQTDMAADVGDGSIKAWSKYSARAKMKELAEGGKKKNNDAEADGETEMTKPQDVEEKEEAKPGRTGFVIKMKGFSGFYSEKTVKEFFKPIKPLKIRIPRNAQKKPMGVAFVEFSTEKDLEQAMGRNKNFINGKKIFLKKSAEEVVEKKASAPPVWEVKAKESEAQVESIGESGRLFVRNLWFGMTEEELEKVFGKFGPLAEVVLPVDPLTKKVKGFAHVVFVFPEHALKAYTELDYTSLHGRLMHILPGRENSSEDVSNEQSSYKKKKDLQQKANSSNSHNWNALFLGANAVADAMAKKYNTDKSRILDSDAKGSVGVRMALGETQIVAETRDFLLSHGVALDSFGQAAGERSKTVILVKNLPTGVTSDELREIFSRHGSVARVVMPPTGITAVVEYLEPSEARQGFLKLNFSKFRSIPLYLEWAPMGVFSTPAPSPVTKVEKKEEKEEDMDAKEGDEDDKDDNNNDGDDGGNDDGQMKTEQDESTEPEPEEGSTIFVKNLNFATTDEQLRQHFCDVGTVQSATVAKKKDPKKPGELLSMGYGFVQFMKKAEAMEALKMLQNSDLEGHKLELKLSTRPASQVRGRQKQVATKQTSSKILVRNIPFEANKKEIEELFKVFGELKFVRLPKKLRGTGPHRGFAFVDFLTKEDAKRAFNALCHSTHLYGRRLVLEWAEAEESLDELRRKTAQHFSDDGPKKKVSKSSIMKDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K223</accession>
    <name>A0ABM0K223_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101845421 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106921.1">
        <property type="nucleotide sequence ID" value="XM_005106864.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845421"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.290.30">
        <property type="entry name" value="Regulatory factor X-associated C-terminal binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038308">
        <property type="entry name" value="RFXAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029316">
        <property type="entry name" value="RFXAP_RFXANK-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15289">
        <property type="entry name" value="RFXA_RFXANK_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulatory factor X-associated protein RFXANK-binding" evidence="2">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106921.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16002" checksum="6C6CEA8B24F3F73F" modified="2025-10-08" version="1">MEEEEKENQAQYSSQLASGRANVEQHSDMENETDLSYLEHESAEFSSSEEEEDRDEGSEPVSLNVTPELLADILHQKQMKILQTPEVMHFLQEHQTMLARNGSQCQSTASHGQNRPLVKDAGLSSALANFSTDSSTQHSLPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2H0</accession>
    <name>A0ABM0K2H0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101848465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 10">Cytoplasmic vesicle</location>
            <location evidence="9 10">COPI-coated vesicle membrane</location>
            <topology evidence="9 10">Peripheral membrane protein</topology>
            <orientation evidence="9 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 10">Golgi apparatus membrane</location>
            <topology evidence="9 10">Peripheral membrane protein</topology>
            <orientation evidence="9 10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107188.1">
        <property type="nucleotide sequence ID" value="XM_005107131.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848465"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="273"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="155"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005107188.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="56677" checksum="C641A0B30592288D" modified="2025-10-08" version="1">MVLLAAAVCNRTGKAIISRQFVEMTRSRIEGLLAAFPKLMGTGKQHTFVETESVRYVYQPLEKLYVLLITTKASNILEDLETLRLFAKVLPEYCRNMEESDIVDQAFSLIFAFDEIVALGYRENVNLAQIRTFTEMDSHEEKVFQALRLTQEKEAKDQMKKKAKEITQRNREMVKSGRNPGFNSGGGFGGSSYRSERSPVIDSGSSVDTPKPSYNKPSKPVPSGPSRALKLGSKKKDVDTFVGQLQSEGEKVADSSKSLSTPAAKTSTPATNQEAVHLVVEEKISLTAGRDGGLQNLEVHGILRLRINEEKAGLIQIAVNNNDDKGIQLQTHPNVDKKAFAQSSIVSLKNPERPFPVGQDIGVLKWRFQTQDEALMPLSINCWPNDNGEVNIEYELEQDNMELEDVLINIPCPSGVGAPVINECDGEHHFDSHKKVLQWRLPFIDASNKSGTMEFTINGHPEDFFPVTVSFVSKRSYCDIAASSVQIQDSGEPVKFSSEVVFVVDKYEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3X6</accession>
    <name>A0ABM0K3X6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Voltage-dependent calcium channel subunit alpha-2/delta-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101864093</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108179.1">
        <property type="nucleotide sequence ID" value="XM_005108122.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864093"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF43">
        <property type="entry name" value="VWA N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22673">
        <property type="entry name" value="MCP-like_PDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046493919" evidence="15">
        <location>
            <begin position="19"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="16">
        <location>
            <begin position="245"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005108179.1"/>
        </source>
    </evidence>
    <sequence length="1162" mass="132186" checksum="4164E23A159C97C1" modified="2025-10-08" version="1">MYLLPLAVFSCSLSATWSYPGEEQHEIGTLAGDVQNWAMLIQNYIIQLANDGIKRDFTQSFLDQANYISEKKDGGDLVQLVKDTLGDYFEKKKRAAQRLAGKVREVYDEYYDKNVSTKAETLNDLPPDTYYDSDIPDKLPKDLVFSPYFRQNVSTLNSTIKIADEVPRDDPHVIDVVLLTQKLEDTFIQNANEDPLLRWQYFGSTTGVTRLYPGREWSTNFAGFYDDYDPRVRPWYIQATSGPKDVIIILDCSLSMKGEKFSIAKAVAKTVINTLTKQDYVNVICARNSHWNEVGKWHYYDTRVLSCQEERMVKATNAHRKDLIEKIEKLVAGGTTELEKGYDLAFDLLRRAPRTGCQSIIVFATDGKDTDGEDVRCGPGYYTRSGYVPGPICKYNFTSVYNVPMEKNKYLAPNARIFSYLIVEDAEMFPGTLACDHNGSMLKLLTGENLITQMYNYFEFLSAIAATENALWTAPYLDSWGLGLMITHAVPVTSAKTGKYIGVVGIDATLDEIENFLTKHQWGSVYSFLINSNADVIFHPKLKPSTTLLEDPIYIPISGLEQDKDGNPSEFSEIEEEMLHGETGMKILNKARDGKTRTYYYGSILDKDYSFAFSLASEDMEFRRSQEPRDRTSIDESYYNLLKMYNSALLRERLPGVYEKIDVRESEERYPELRITYKYSTIFLAPQSHCDPIKYMYNDSLEEKTLDAHFWINGYSEDQGCESRDQKFNKGVRADVLITQPIEKIWRDRKFESIDQVKWTNVGLRSGVFRTYPGHRSTRGYDPTKRPWYKRTSSAPHKTSVSTPYMDSAGVGKINTISQAVFEGMTPKTDEECMNFTRGNFMGGCKCDVDDDCYIKKCYLSKGPGPNSDHRRCATERVEAVTGLDILYDDFQKKSLESMQASDYKKSCGQVYTCPNGEPGCETRCYLFDTAAFLVMDPDFLVANALDESRYQSVTLGRKEGEIMKHLVYHHKFFTRKESIDFQGSCRISPKEPKLTLEGQPQKPEDTDDYYKNRGPIPKFHSDFGCIQDVVSFRANDEALGRSGMITGNVSGPCMSGFYYVTALPQTNLYLLVIEDWLAYKQSLFYNFHCKITQSVVNSGAYRIINGTCAHKDTSESTLRDQGKCPKLNDVPLKCRYNTGTRLTATAHIAVLTGTVMWVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K584</accession>
    <name>A0ABM0K584_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Electron transfer flavoprotein regulatory factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101849006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109047.1">
        <property type="nucleotide sequence ID" value="XM_005108990.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828455.1">
        <property type="nucleotide sequence ID" value="XM_035972562.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849006"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828455.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="10222" checksum="F8DCCCD2B6FAB180" modified="2025-10-08" version="1">MSQPALRYQVKLLYKTLLHLGKEYPRGADYFRTRLHAAFMRNKDVTEEAEVKALVAKGEYVVKELEALYMLRKYRTLKKRYYDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K638</accession>
    <name>A0ABM0K638_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epimerase family protein SDR39U1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109612.1">
        <property type="nucleotide sequence ID" value="XM_005109555.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859133"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05242">
        <property type="entry name" value="SDR_a8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092:SF0">
        <property type="entry name" value="EPIMERASE FAMILY PROTEIN SDR39U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092">
        <property type="entry name" value="SUGAR NUCLEOTIDE EPIMERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="2">
        <location>
            <begin position="246"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109612.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32146" checksum="1B86A2E23C6DE4A7" modified="2025-10-08" version="1">MSIIVGGGTGFIGRHFAKLGASKGYKVISVSRNAGPNRITWQDVSRSGLPEDCIAVVSMSGEPILQPFKKWTPDFKERIRASRVDKTRLLSAAIAQSSKPPKVFVSLSGVSYYKPHPNKEYTEESLVEPYDYLSELTRDWERAAALPDTVSTRSVIVRTGVVLGKDGGMVQNLKTPFYLGAGGPIGSGKQWLPWIHVDDMVGIILFSVENDNVKGVLNGTAPGVVASGEFTKSFASAMWRPHLFPMPAFVVNNMFGSEAGIVMLEGQKVTPKRALELGYKFKYPDVTSACKELVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6N9</accession>
    <name>A0ABM0K6N9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110004.2">
        <property type="nucleotide sequence ID" value="XM_005109947.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852126"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="180"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110004.2"/>
        </source>
    </evidence>
    <sequence length="382" mass="41971" checksum="66A27B262C903D9C" modified="2025-10-08" version="1">MSSLQYEGCNNFRMRLVLATLSGKSVKINQMRPEEDDPGLKDFEISFIRLLDKVTNGTKTVINETGTQIIYRPGLLLGGGIDHDCHVARPIGYYLEMLMCLAPFTKEPLRAVLRGVTCDKDDPSVDLLKLSVFPVLKRFLGTDEGLELKISKRGAAPDGGGEVLFCCPCRQKLRPVKFLQPGKIKRIRGVAWSVRVSPAFVNRLVDSTRSVLNKFLTDVYIYTDHMKGNQSGKSPGFGLTLVAETTEGAFLAAEEVSNARKSGEGPSIPEDIGKKAAVSLLQEIHRGGCVGSMAQSLAALMMVLGQQDVSKVQMGELTPYTIQFLRHIRDFFQVTFSIKKDQKPVAPSTDDEEEPQELRVGADKLILTCVGVGYSNVSKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6Q4</accession>
    <name>A0ABM0K6Q4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">enoyl-CoA hydratase</fullName>
            <ecNumber evidence="5">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101856538</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
            <dbReference type="ChEBI" id="CHEBI:62616"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:31188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:31160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:31165"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005110023.1">
        <property type="nucleotide sequence ID" value="XM_005109966.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856538"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012803">
        <property type="entry name" value="Fa_ox_alpha_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050136">
        <property type="entry name" value="FA_oxidation_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02441">
        <property type="entry name" value="fa_ox_alpha_mit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612:SF3">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="15">
        <location>
            <begin position="360"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="541"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005110023.1"/>
        </source>
    </evidence>
    <sequence length="759" mass="82179" checksum="CBF7413620D6E076" modified="2025-10-08" version="1">MASMRLIGMANGLRSTFGLSKNCRLFSSSHVMSGKYVNLEVADDVGVVRFDSPDSKVNTLSQAMQSEFYDCIQQINRDEKIKAAVLISKKPGCFIAGADIGMIDACKTEEESVKLAQAGQEAFQAMEDSKKPFVAAIMGTALGGGLETTLACHYRIAMNNKKTSLGLPEVLLGLLPGAGGTQRLPRLVSVPNALDMMLTGKMIKANKAKRMGLVDMTVEPLGPGVADPEQNSLAFLEQVAVQTARDLAAGRLKRTPRKKGMSDKIMDKLLGYDFGKNFVFNKAKGQVMKMTGGLYPAPLKILEVVRTGLDKGLKEGYVAEREGFGKLAMTPESKALIGLFNGQTACKKNSFGKPQKKATTVGILGAGLMGAGIAQVSVDKGMKTLLKDMSLQGLARGQDQVQKGFDLSVKKKKISSFERDMIISNLDPTVTYDGFKDCDMVIEAVFEDIDLKHRVIKEVEEQISPDCIFASNTSALPISQIAAASKRPEKVIGMHYFSPVDKMQLLEIITTDKTSKDTTASAVDVGLRQGKVVITVKDGPGFYTTRILAPMVSELLRVLQEGNGPKKLDKLTKGFGFPVGGATLADEVGLDVAAHVAEDLGKAFGERFQGGNPEVLKEMVAAGFMGRKSGKGVYVYEKGSKSREENAEALTILEKYKLTAPEGFTDEDIQYRLVSRFVNEAILCLQEGILANPLEGDIGAVFGLGFPPFLGGPFRYIDLHGAKPLVDRMLKYRDVYGIAFEPCQLLKDHANDPSKKFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7S6</accession>
    <name>A0ABM0K7S6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101845584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005110803.1">
        <property type="nucleotide sequence ID" value="XM_005110746.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005110805.1">
        <property type="nucleotide sequence ID" value="XM_005110748.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845584"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="669"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005110803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110805.1"/>
        </source>
    </evidence>
    <sequence length="896" mass="99131" checksum="8313AEE604EB47AE" modified="2025-10-08" version="1">MQWQPAPGKQLLAPFGHQVAGQSSMLWYDSSTVCKPLIAREHFVYRTLPPALAEFTPEYRGEIEVQLQEDNGYIQLYGVSVTSQDEHGSPPCPCFTDPEDDAECKGHCCPDATPPGRPADSSSPSEGDGHDKDRSCVIRVLSSGSYEVCPSTEEMFYTKTSSPQHPSTQSLNPWSLKNHKRLLDKMRKSEHSHNRVRFILLKNVVAGFDHPCILDLKIGSRLHADDASNKKVASQSRKCRETTSSSLGVRLCGMQVYQTSSGIYKNYDKFHGRTLTDASFKAMLYEFLHNGQRFRSELLRPIIRRLSQLISCLGDLSSYRFYASSLLIIYDGNVNDNDTFCDSVENSQGLNNVNNHDVIRSSSHGMNAKNKSQSTHDGKDFSSISDFNLNLEESSENQFSVSESRKHEWSHDGISFSHYDTLKSHNNTSPPRVNISPSQDAQISLSGLPPKVRCPENGSKMSALSSGFYKCALSNSSSPSESSQKTLCSSRSCRNSSAQTHTHEHPLPSTQKAADIHSHSSAAQEERHQKLSDLTHKGSGVVTTEPSQTGVNPESQSYNLSSSLVESCTYVVNSGDDHASRGKKRSDICCTDQINNRSSWEGNRGHVVTKSDSPSELHGASPGIASHSTNSGWSQRKPSEKLAAHYDDGAPRLTPKHIQSCVQHPNKTLRTGQHTKMPSQRDTPSSPNGCSPSVCPKQGSRVSPSEETHQNLHTQPEAEGDAAFLPRHTHTFYPGDVQNSNTKVPTRVNDSQSSRVQDAFRRGESCLIPTTANNGVDCDVVHEQNLVSPSSPVRTPIHNVNTHDTKITYTANLPSDNEKLMDKKGKLKECDKECDKDEERFSSSGSVLMDVRMIDFAHTTHRGFVQDKCKHTGPDRDYVNGLKNLVRLFLELEAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8F0</accession>
    <name>A0ABM0K8F0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/potassium-transporting ATPase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101862151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111261.1">
        <property type="nucleotide sequence ID" value="XM_005111204.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862151"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005111261.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33742" checksum="40CE89A84CA184AB" modified="2025-10-08" version="1">MEKPTLKQRLDSFAKFLWNGETKQLLGRGGRSWAEIGLFYLVYYACLAGFFAATIAVFYQTIDSHHPKLQGDSSLLKGNPGMGFKPMPDIDTTLVRSTRNPELKKHIKAMTKSITDVLEDYEIDTLDNTDCGGIDETRPNAKTSCRFNYTALTKNCNAGNNFGMDDNQPCVLLKLNKIYGWSPQVWDSSEIDKVPKEIRSSYTPDRIWVYCHGENPADEDNIGHGQIEYYPMQGFPLAFYPYQKQQDYRSPLVFVQFRNVTRNLGLMVECKAFAKNIEVDQTDKQGSVHFELLNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8Z9</accession>
    <name>A0ABM0K8Z9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Adenosine receptor A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101852373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005111723.1">
        <property type="nucleotide sequence ID" value="XM_005111666.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852373"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="18"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005111723.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34948" checksum="36E46B580EBD621C" modified="2025-10-08" version="1">MVKVVVISCLLSLFGVASNLINIVVFAKQGFQDSMNISLMGLAVSDLCSLLPTIWLSLCANPLFYNSELPFDPRNMVNVTGAVPHIIFFKIATFITAFITFERCLCIVVPLKVKTIITPGRTKTIIISIYIGMSVLVIPYCLGNRLEWVFDFNKNATVLITTFTAERDMLETITFLTQGVFATTFSFVFVICCTIVLIVKLKSKTKWRKATVAKSDRASGGVGVKDQKVVKMVTLIAVIFIVCAVPSTLLFLYMVIDPSFRIGGVYGNVFLVLWSSSYLTETVNSSVNIFVYLKMSSKYRAVFLKTFWNKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9D2</accession>
    <name>A0ABM0K9D2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Angiomotin-like 2a isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the angiomotin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112006.1">
        <property type="nucleotide sequence ID" value="XM_005111949.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860544"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009114">
        <property type="entry name" value="Angiomotin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051747">
        <property type="entry name" value="Angiomotin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024646">
        <property type="entry name" value="Angiomotin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826">
        <property type="entry name" value="ANGIOMOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826:SF14">
        <property type="entry name" value="ANGIOMOTIN_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12240">
        <property type="entry name" value="Angiomotin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01807">
        <property type="entry name" value="ANGIOMOTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Angiomotin C-terminal" evidence="8">
        <location>
            <begin position="596"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="534"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="722"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005112006.1"/>
        </source>
    </evidence>
    <sequence length="869" mass="93852" checksum="FD12161E0C2D2F41" modified="2025-10-08" version="1">MGIEQLQESIYEHSREGLLTGGRWLDMQNYRDPPPYPGHSKQVFTNQPGFRQSFSGSETSTDVSLSSTENLATSQRQEPQGEETQTSLYSHLDLGADGSSYSILARLGMPPGAIDSAGKFSSAGRGSASTTMSYMNPSSPYGPDRSQQLQMSTSVVGKSKLGPSMASPSPLGSQGHLTVPQWQVHHRAAGGGGGGYMHLQSSNEGGESGIGEFTSSSSSSSASRSAKEFSSSSSSSASTVTLLSGGSGGEYPSYVTSSARTGLVASSAGGLPGGAGVGGVVISSSLSSSSSSLSTHHQYLSPRVPPVSTYHHPHPYVNTHWTMGSGDSSSSQTPPLSYLGNLPPPPEYPGAVGGMPGDVTAADKSTDIRTCRSYEMMDKVNTQQCHPDLRLCASSPGIYVHDTKFSSPDRSTNTSADDNDQASIAAKASQMVEMLTEENRALREELAISSVKVARLQKLEMEIHKVHDSHTGLIKSSQKREALWQAMKRKLEERIQVLEGHGGPGKSDSGKSHHSSSSSDSEFRAKLAEKDALISKLLSQNQELSLAKDQMEGENAQLNLSVAEQRAHVDIYENALLNAQSKVLTLEEERGKKQSYLDKVEQLQGALASLQAASEKQEKKSQEMRGRLEKELEMYKAQEKSGVSKRAETGRDDGKSVGMLRKMLDEKDARIMQLETEIAELEQKYVKEATLRQLNMDETPQAPKEVRLAALEKSSSDMGKLIDEAKTEKLKHMEELHQSQRKVAELEAKVKQLQTQVVEKEAMVKVFQRSPLALARSSSLHALCHSPLHSPRPSLIASHAWQGSSPSGDLGVAGGCREFATIRHMKTGSASAIELGRKMSMEEDLLTKVQNLNSESKSDSEDEVKLWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA64</accession>
    <name>A0ABM0KA64_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 167</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005112629.1">
        <property type="nucleotide sequence ID" value="XM_005112572.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849587"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028194">
        <property type="entry name" value="CC167"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31759">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31759:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15188">
        <property type="entry name" value="CCDC-167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005112629.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13813" checksum="91852A7A35333187" modified="2025-10-08" version="1">MKCVWEIDCHPNFRHCCFGQNWKIEQLETEISKSESRLDDIERLGRLADMTDEEWSRLKVEKTQLEHQLVTNRKKLKKLRWENWKTMIVSVIILGAGYLTFTLLYNTPSAEVAQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAM7</accession>
    <name>A0ABM0KAM7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Turripeptide Lol9.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101864437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112976.1">
        <property type="nucleotide sequence ID" value="XM_005112919.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864437"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005112976.1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10060" checksum="DB563707D508E99C" modified="2025-10-08" version="1">PCQGHTCEAPKLCQVGPAPARKPECRCSYVCPTEINLVCGTDGRTYSNQCLLRKQACKSRADIRVLYNGKCSPGFSFIKGTVQDEYNNANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAS7</accession>
    <name>A0ABM0KAS7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC101849429</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101849429</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113074.1">
        <property type="nucleotide sequence ID" value="XM_005113017.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005113075.1">
        <property type="nucleotide sequence ID" value="XM_005113018.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849429"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="110"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="709"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005113074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005113075.1"/>
        </source>
    </evidence>
    <sequence length="1309" mass="148133" checksum="00DE9D749F967860" modified="2025-10-08" version="1">MQIKAPPNFQPEDARARQTYAPPVHARYRKFDLYRNVQQFYYIDNHAIQVAQTEHDNFTDLIYHLVYSQNLQADLDKVRVIFRWMTSKNMYTINFREGAKPNSPEEVLLSFKNKQGTYARIFETLCRFAGVHSIVLTGYAKGLDYRPGDKFKGNEYNHSWNAVLLDNNWYLVDSHWATRYLVSEKNMPENLVYEYDDFYFLTDPEQLIYSHWAHKNEWQLLNTPVTLQDFENLPLVKSYFFKCGMFFVSHHNGVVDAKKGRLALTLGFCKPTNFTYKITFADTGEEVYQGQKLKNYALQHQGQNQTTTFVFRAPRAGQYYFTIFGQLLTGELGVKNIFTASAEYKLVVDTPSSDAAPLPSCSDSSWGPGVAVDQLGIVATPADGIVTTDDGRVELEFAKTKPAYVLCKLRKNGMKDEELEKYITEQDEGDVVKVTAQLPARGEYGIEVYGNDPAKDGDTYTHICQYYVHYAPPAEQQSAFYQESPERRGLTSGQQPVKQAGKYNAGSAGLNNAGGVNYDDEDLPPPPPELLQQQYLYGTVPDSRQQAVQSNLAYPQGQAFTSYAPGVGETEGQKPQQAEITHIPASTKPLEVEKRSVGQEGIAAPASFQLQPVKSDQGSAPTPAPAGQQQKPTLEAIDRNVLQSVDDHAIQVSKSEHNNFRDLVWDLIYSKNITNELEKVRVIFRWLATKNLKEMNFDTVDKGSPEEVLMGLKTGTTTYAMVFDTMCNYAGLHSKIISGYAKGADYRPGQKFVPGTNQHSWNAVYIYGTWCLIDAHWAARRIIGKQASTEDFHYQLDEYFFLPDPHQLIYTHFPDEPQWQLLERSVTLQEFEAMPHMKPQFFKYGLEFVTHRTGVIHSRGELHIRLRYPSDKIAVAFNFTIQFEDGNEEYGGVKLNRYGLQESSGRIASFSLRLPVQGSYILYIYAKEDTPENKDNVYAQVCEYKIEQEVVPSPAPQPYPPCSYLNWGAGSAFYRYNLSTYQQTATLNTREGKVELQVKIPCNMQFMAKLKANDFADPELEGYVLHRIVGNTAYFNVSCPGRGEYGLEIYANNPDKEGSTLYHVAQYLILCQEDVKVERLPTLPHGYLGKQQRFDEFGLSCVSHVDPVVHLDVNTVTVALKQSEPMRVTANLIAVDSDEEFPDFVFSNCLDSQITFIVNLPSAGYFKLQIYAMPLSDPSQQLPGVFNYLLNCRAVTQAVFPFPKQYAQWKEGCFMYEPGVIPTNRGPHAQQVQLGRLPGQVNFRVSIPRAEAVAVVADQNWTHLERLQGFEWAGVVDVNGLYGNGVKITLNANFGGDKTSYSTLLEYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAX0</accession>
    <name>A0ABM0KAX0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Arginine-glutamic acid dipeptide repeats protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101856711</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113187.2">
        <property type="nucleotide sequence ID" value="XM_005113130.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856711"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859">
        <property type="entry name" value="ATROPHIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859:SF11">
        <property type="entry name" value="GRUNGE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="9">
        <location>
            <begin position="214"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="10">
        <location>
            <begin position="352"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="461"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005113187.2"/>
        </source>
    </evidence>
    <sequence length="506" mass="56184" checksum="17F8FAE45626821E" modified="2025-10-08" version="1">MDPDASGGRRGNSPAPKHSSLNSGSSSNSNNSSMNSAANTITTNNAVASSAVSGSSSNSPITTTTTSNNSTTNGGTISIHNHNINHHNNNNNNDDDNGNASSDMNEVDFDKADTPTNAHHRTHNNSASRGDPEQSAGSYSPKSEKSGKSSAKKKATSKSSLKMAVDKKKLEKFVGEGEQLLPVPRARRRLKGSDLGYMVKRGESVVRYIDKDGIVYNPNDTAYLQNREKGKPYFVCAIQRFNLTKRDTLMVGVKWFFRLSEVPGSVYHHLTLDRELHRKNGEDIICDSSIQQRELFSSEATDTLPITSLRGKCEVVQYSDLRAACSFVPSPDHFFYILAYRPDNRRLATTQGEIRVGPSHQARLPECKPGTSPAEMPERCESREEIRWRPNRVVDGDLLMYLRAARSIAAFAGMCGGSAEDRCEAEAMDETTVNALDTLHKHNYDTSKSLQALVKGPSVMYIEKKWNEEDIKRFAKGLRHLGKNFFKIRKEHLPHKDTSELVEFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBC9</accession>
    <name>A0ABM0KBC9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Circadian locomoter output cycles protein kaput-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101859999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113503.2">
        <property type="nucleotide sequence ID" value="XM_005113446.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859999"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047230">
        <property type="entry name" value="CLOCK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055">
        <property type="entry name" value="CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055:SF3">
        <property type="entry name" value="CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005113503.2"/>
        </source>
    </evidence>
    <sequence length="164" mass="18765" checksum="C7BACB5CC34343E0" modified="2025-10-08" version="1">MSFTCHLKRGTIDPGEPITYEYVRVCGTSQVIGDSDEDAMVNDNSDFIGIDLPEQSLCFCCTVRLQTSHIIREMSTVDEATNEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHPDDLEIVSKCHEQCKRFSYFFLLPSPPHLPLEASQSEMYCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW01</accession>
    <name>A0ABM0ZW01_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein lingerer isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101845532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935680.1">
        <property type="nucleotide sequence ID" value="XM_013080226.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845532"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14277">
        <property type="entry name" value="UBA_UBP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022166">
        <property type="entry name" value="UBAP2/Lig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12478">
        <property type="entry name" value="UBAP2-Lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1061"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1164"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1285"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1320"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1371"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
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        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
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            <begin position="487"/>
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        </location>
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        <location>
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            <end position="667"/>
        </location>
    </feature>
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        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
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        <location>
            <begin position="738"/>
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        </location>
    </feature>
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        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="836"/>
            <end position="849"/>
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        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
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        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
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        <location>
            <begin position="889"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="921"/>
            <end position="955"/>
        </location>
    </feature>
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        <location>
            <begin position="964"/>
            <end position="992"/>
        </location>
    </feature>
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        <location>
            <begin position="993"/>
            <end position="1006"/>
        </location>
    </feature>
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        <location>
            <begin position="1061"/>
            <end position="1095"/>
        </location>
    </feature>
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        <location>
            <begin position="1198"/>
            <end position="1213"/>
        </location>
    </feature>
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        <location>
            <begin position="1371"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1390"/>
            <end position="1404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012935680.1"/>
        </source>
    </evidence>
    <sequence length="1416" mass="151539" checksum="89173A4D6E8017F8" modified="2025-10-08" version="1">MSQIHAAQHMHAKMVADQQEIIELAMKDSSDPLQASRTHAASHPGRGFPTPTLLQPQQQQQQLYLQQQQQQQQQQQQTLSKNEGQSNKIQPTQDQIRLAQMMSTNQTDANPDTVKELMAMTGKSEDVVVIALHDAEHDADRAVMMLLEGGEEQQGEWREQGGKRKKKAASQKDGSNHLGDDHYDSRNKDRGDRDDRDRDGGSDRQDLPPRRGRRNGGPPPRLARGRGRERGNFGDRDNNRDRNNAEDWDNDRGDDKRDRSGGDRGRSRGRGGFGGRRTGGGGRGGRFNNSGDRDNRSYNRVPRFEKMNNSQPLDGPEIDTWTNETAETNTSKDTDWDNWNESWVNEEDQWTGTLEETKVFTPSQMKIAEPDPVISEPPSSLGQRLDVGSLFSESAKFSKAPDYSKPSGDAYINQFKQAATESIKNTIGIGSSSRTPQSMSSMAMPQQSATNSLGLSSLTQSSSQVQDGVTSVLSSLSQQQGQQVASMSQTMSQLSQFSQSQMGMGSGQQSQVSGMAPQPAQLPGLGGQQQASRDQAPPSQSRIPSVVQQQQQQQQQQNLAQSGLNNNLQQRPKPQRSKLPPPSKIPSTAVEMPGHIPRNPQFDLQFGIDFGSESNSTFAFGTGSGESTTAANTYSSTSNGSSSVISNHLNQAHVSNSSSDTNSMVSSIMASPSAGSAKVPSNMEPQPSARPPAVFHNSVYNSSSPKTESQNIEREQNKISGPESMPFPSAQLERKSSPMMSTQRPGQTSQNLNTGSLPPSKNDTSSNNIGNNYSASNGYASSYQGHQKASSISQTQAYTHTTNSQPPQGSSFPGQFPASQSAYPSSAQTQFPAPPSANQFPPTGQPPQFNNTQTQYTSNQNQFGSGGSTGQHPSMPHGNHQSQYSSNTQNAYSSAGQSQYSGYQNNAPFPSHPPSQSNFASSSQTGGPSSSLYPTSTQSSGSSYTSQSNTYQSPSAGSYHSRDNQTGAAVSTQSSSGVAFPATGQTSSLKPATSQTNSSYNSQNFNASPAPLQPSSLANKLGESLSKMTMKDTTTALDGHQSTQFEHSSTSSTTTVSTALSLPSSTSTASLSTGTTTISSTSTATSITSTSRIASMPSTSKAPPNLPPGVPLMGQYIMGQSTMPPFYSMQPPLYGYDDVQLLQQRMPLQAGSYYDMSAFPAPAGSTLPTGRDQQPPIPSVPFSGTSADTSKMPRVDAQSPNSAAQPQNPHSTAQPSLINFHYGYYYPSMFPAGAAGLQYPMFPIPPVTNAAAHAGTTATTQFQKSYPSHVYTTKGYDELNQAQDFSKTGYGSSPSAGKTSGTRMSTRAATTEMAPNAYKSHTQGFDKQGFHGGTPPPFNLPLATATQAGPMGAPTTPYGAPFLPVMAAHQAHSQMMHHPMQQDSSSSSSRGLNQNTSQGKTGASKSYGGAPPYWNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWF1</accession>
    <name>A0ABM0ZWF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011308</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118477667</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011308</name>
        <name evidence="4" type="synonym">LOC118477667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935925.1">
        <property type="nucleotide sequence ID" value="XM_013080471.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825591.1">
        <property type="nucleotide sequence ID" value="XM_035969698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011308"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021884" evidence="1">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825591.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17497" checksum="3A3265C3951B3A02" modified="2025-10-08" version="1">MAAISVQYLCFFPTFALLVSPLLANAVSYAQGGLRSQVETPDRLLAVLLLAPDKKGDSTSWHVDGARILPYDDYSRPESMNMALSDDLPATILPDGHQDIDVRTYGKRGYYHPSRMEMFKRSTLNELIRRLMAMRGHHYSDGRATMMRFGAGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWF7</accession>
    <name>A0ABM0ZWF7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase RNF216</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101856330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935931.1">
        <property type="nucleotide sequence ID" value="XM_013080477.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856330"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="182"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012935931.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="57446" checksum="63763E1B189743A0" modified="2025-10-08" version="1">MDDQGETKAEPYRGAPKLPYSRWDCRRQLLVDFDTLYARDIDDVITFVGPNYSSAYKALNNVMKTVRERRAAPVLKGKYNFRNRRKSEIFHPVPVVIENDLGVSTVLHFTPMVTSRRVNKQRRDTAIPEGLRPEVERMRKLFSVGTSDRNTVCDRETTRRPPNQKSATPATKADMEEPPNDSLIECACCFGDCEFEKMAQCSEGHLVCINCLQSYTREAVFGAGKIDLHCTAADCTAFYPISELRRCLPNQTLKKYEEKALDDNLRQAAIENLVKCPHCDYAAELSPRIKVLECANDACLQATCRDCKTNWVEHKGLSCDEIEQKDETALRKKYEEKMTEAKVRTCSKCFAQFTKDKGCNKMICRCGMSMCYICRKSKITYKHFCQHVRNPGEGCKTCNNCSLWTNPEEDDERAIAELQKEGQEKKKTLGYNEKIVIGMPDEKTVNDLLGETEVKSIPVDLDNTVPERRQILNEREAPPQNLLHQCIKNLLHFTTRVLPSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWI4</accession>
    <name>A0ABM0ZWI4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Prostamide/prostaglandin F synthase</fullName>
            <ecNumber evidence="13">1.11.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxiredoxin-like 2B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101851859</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>prostaglandin H2 + [thioredoxin]-dithiol = prostaglandin F2alpha + [thioredoxin]-disulfide</text>
            <dbReference type="Rhea" id="RHEA:28214"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57404"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="EC" id="1.11.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostamide F2alpha + [thioredoxin]-disulfide = prostamide H2 + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:26373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:53081"/>
            <dbReference type="ChEBI" id="CHEBI:53082"/>
            <dbReference type="EC" id="1.11.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peroxiredoxin-like PRXL2 family. Prostamide/prostaglandin F synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.20" evidence="13"/>
    <dbReference type="RefSeq" id="XP_012935966.1">
        <property type="nucleotide sequence ID" value="XM_013080512.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851859"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF29">
        <property type="entry name" value="PROSTAMIDE_PROSTAGLANDIN F SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012935966.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27224" checksum="0D8E5F391933E5DE" modified="2025-10-08" version="1">MGSELQEWLTIAVWLLCKVVFWPFLALVNYLEPLEAPTTTMEPSKIAKNQVKNVSTGEMVPIESFWKDSRVVLIFLRRFGXQLCRVGAQQISQLKPRFDANNVKFVGIGLEELGVEDFVKGEFFKGDLYIDQKKDCYKKLGFRRLNVFSLIPSMFGKKTRDTLAKGKEENVSGNFQGDGWQNGGAFVIDQGGKALLTYKQENPGEHVDPNDVLKALGIEGSVEVEAAPAVDCDNGACALPKKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A073</accession>
    <name>A0ABM1A073_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011799</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938168.2">
        <property type="nucleotide sequence ID" value="XM_013082714.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011799"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012938168.2"/>
        </source>
    </evidence>
    <sequence length="3241" mass="362224" checksum="E0CC3874F816B01C" modified="2025-10-08" version="1">MIATLKSMLKVNTPTKQMLSMQGSADYREDKSLKMDGTLDVYRLLKKPANMKLALVKNAKKRGVRYDIDVILKSSVASGKLDSFTFIKDSGLLSTKTVLGYTIPRVAKNKITFGGKFNDRSTKAYKKYTIKSNLDIAKNPEYNLDLNVDLDHKKKHSEAEVELKYGPNPKDKTKRLFWSTSLNRKLATWKNAILTFKMNALAPAKIQSTFNAPTCSLSSTQGVDVSLVHKHQHTPKMIDSNVVLNYGGKGKDLSAELIVRDKSSKLSKINGKAVVAWPGSAYTLTTGVDQKSAKQYTHTLNLRSNSGMKHTITTLYKTPKGKAHQFSTKFLLSGMKPVTVSGSTKLDPRNFEVSGEVQRGKEIYGLKTNAMITKAPSAKVEVELFYPTRRMTLLMDGGKQNSKFNGRMEAAWDADGDKSQKVVVDGSGYMKSTKKSMSVGGSLIFNSPFKNYEDIMTAFKYGNDDSQHDLSGKFSWAGKGNQVISSLTVKRPVSLSNLLITTETKTPFKGFRVISVDIDHSLYPTLKTTMKGRWDKENGKLSIEGQNLGDWYNRNIKGTVSLKSTLKNAEDVTFHLAHADSAGRLVSNAALIHNGKSYGYDVNMDHNRNGWQIRNTGDLLLTMPTAKVKSTWKHRSSEKDIKSTMTSEWGKNRLLVDVDASHDLQNAGVMNADFKMQSPWRSLRNIDLALSHKHGNGLIMNNAAYKHDGKIRASSSVKGNFRPSEFDFKFGIVSPFTEDIDGKMNSKFSSYPMTAAAELSWAPRSKAVMEGSLNIASWDNANVDVKVVTPFREYRNIVLKASNKNERGEIVSHMNLDYGVRKNIDMESRMACNDMKKMLRLKMRTPFREMQTLDTGLTLTGMMTRFDGSADFEMVPVIGKLQGSVNWQYADDGLKGNLRVSTPFPEYPYIELSTSSQMKGRSRQSSVSAEYYPRQTYRLDSSYTLEMPYAFEATLSTPFPEYDNLGVAFQHNQSPSSVMSHGEVRYQPDKKIEGDVNMDWTSVIEGTVILKTPFYGYESNKVLLRHQGDMDAFSSHGEVNVAGKSVSADASFNSGYATTGTFTFNSPIPGLESVELSMNKKGNSNNMRGGATFRLNGDRSQANFNHRMSASTLKSTVSVNTPYSDNFKLSVDHNGDINSFTNKMSLNYGRRYDIDTIFAFDHRQPDVSGNGMIKYKLAGPRNVARATFRRTGELEDMSFSGTASYNRRDVSLNGSWKLLGGIEGTVRIATPFNKFRNIGATLSHTGDVYNFRTESNLNYMDNQNINGKMEMSSDGLRRIRFNTEMATPFREIQSAKLSVEHDYDEYTMALTGGAKLTTTIGRFGQGSVSYTKSGDLENFSIQVKGKYANDEAAVSVTKRGSMSDMTMSTSASLNGQAISMDGALKTLGGFDGTVQLKTPFRDYRNVGMKLTHRGEINDFNAQASLDYMDNKNVNCQIEFAADGIRAIRLSSEMNSPRELLGTSKMTFNHEYDTYRRSIATRGEMSSAIGGFGDGNFRFSKTGDLSDLNMEGKAVHNGADMVYAKITNSFQLRALKTIINFKSAMTPSLEFTVDHNGDYLNSNTKATGMLGSDNMMSVESTLTNRGDVFDSQGTLIYRTTQFGASRGSLNVHKEGEIDNFSVTVTGDLNGDKSTVISTFKIKDEITGSVSVKTPIRGYQNVGMSFKHSGNTERFHSSGDITLRDGNRYSAKLDFYMYLLRRIETTLEVRTPIQGYEFTKYEYRHESGPDSFVYYQTLEYGNSQKITYEMKATMSPNPDLSITLKTPFYRYEDMMASASLVNNWPTASVSGKVNAGNGNIFVVNGAMDVRSDMSGSLTIATPVRGFSDIGLSFQHSGELRNFNSEGRITYMDNKDISGKFGFKLNSVRVIAELKTPFSGYELTRYEYTEKNNRRQASSTSILMYGANQVIKSTTEVVYYPNSEVKVNVQTPFRSYEDMSVIYLLDTTGPRYRLESNVNLGVGRTLTLNGGFDSSDDVTGYIDLKTPLNGYRNIGMNFRHIGNTQRFNFEGKMTYADSKDISGKLNFYRYMWRRVTASAELSTPFSGLETTKAEVKYEDRSTSMSASSSLQYGNGQTLESNVKLTYSPNYDLLVIINTPFYEIRNVRAMATADLNAPSYAVTSGLTYGYNKAFNANGKLNLFSANKLDGSLEVKTPIAGFEFTKVDYEHKIDSSSVDGSASLTYENGRKLVSAELQSTIYPSFDASVTLKTPIYGYSSIQGSAAYDSSYNKYETSSSLKIEGRTQYTMSSGLDYSVEPMRVFTKVSTPYSDFRDVELVLTHEGQLTNFKTTGFLASPLTDNVNAQASLDYQSPYDMSVSASMKSSMAGMDDLKFEMKNSDASGEKKMNAIAGWTDGHQIQTDVVFRHQDGWYEDLTTADISMSTPFTAVRSLSVQTEKTTKSEGYEGKLAVNMNGAQLLDMSGEYINSDKREATVTFTQPWAMQYTASGFSQYGKMEADLMANWNRDELNSNVRVVAVMNDKSDSYLTDRSMDISVEHASRKMGVSNTQTLSDAKLTSTGKFYWDSGDEDQVSYDLTMADSSRRSKAISEASLKLGLPSRTLEWAGSVSDSPAAKTADATFNWDAGRDDTKQVGLKAKMTRGKSLRGDVTLSMPSIKKEIRVDGELMLKNGRIILDSKTDVSYSSDARKTLTLTSKVQDISDYYSNFNYSVELGLSHPYTNIDVKMNSHLGSSDERMTAGLDTSYLTASRQTKNLAMLAEINKIKKQISLQMFSPMNNIQFVGDVVSSSPSKLRLLNRMDGVETFRSDLTLDSDKQMAEISAVMGSDTYSLTALYPNSTAFRAFISHTTPDVRHKEALLAVRLNTTRLLHSRLAWRPDLWAGLTSGLEGKATRAGIRAAENWALLNAAVADEFAAKYGAVSSSVKEELSPLIDMLERELNRMAYRMNDVSRELRAIYQRNDFYAQDMGAVYTTMQREFDSMTIKYRRTYMELIRTLRQAVDDMMAFPARERYSEFVASGVAYMAKNIYSSLSYLEEYSAEAVKVLTEYKEKTQKFAKSVANTVYNATYVDYISNRVKNVDISPYITSFEMPEEYSNAIAGARSSAISGLKTLWERPEIDGVRSELNSVYQKGAWTYKYWNVEENLKTNIERMAKLLHEIVEDELKELSDHHRKLFKNPITVWAPEQGEIQAEIPLPFDLKRLDEMPDMSPLVNKAEKFAQEVAVYLPDQTTWENMKQSVSDIWPEAAGEVEEKEDTDEVRLTKYPPSRRFRMKKGGKKLRKYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A075</accession>
    <name>A0ABM1A075_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011802</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938171.1">
        <property type="nucleotide sequence ID" value="XM_013082717.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011802"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938171.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21764" checksum="73396F16C50FA648" modified="2025-10-08" version="1">MPMGYANRFNLVHMYVEMTYNSFQGFILALLFCFLNEEVHSEIKRIWWRRRTRRRDSVATRSFVLSSFKRGSYHNNRTAINNVNHQHTTPNQQQPLNSSAHLSRSDSADVKQEAWSGRLKNNVLRLLRRGRSSERERGGTIRNSTSPFNLKDDCRMELSRIENNDDIDAPMRLEDSERNEDPTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0V2</accession>
    <name>A0ABM1A0V2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multidrug resistance-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101864068</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012938536.2">
        <property type="nucleotide sequence ID" value="XM_013083082.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864068"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18592">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18599">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF447">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1004"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1110"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="196"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="549"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="872"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1205"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="517"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="783"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012938536.2"/>
        </source>
    </evidence>
    <sequence length="1448" mass="159658" checksum="9D471026BD564CDD" modified="2025-10-08" version="1">MDATKDFTEATAAAADDDSPLTGNDNERMEGVREEGVREEGVREEGDREEGEGVKEEDLEEAHGMTSADRTASESFLNVSGEDPEFRPRTRKPGVSRYKHGLRTLLPVRCEKSPPGYLPVDSTGCVNYMTFGWMTSLMWSVFRHGVGPDVKNLRLTSSKFSIHSIQGHWQEELSTKNVSEASFGRAIYRAFRTRLFIGTFISLVYAFLSLANPIFVIRYFLEYLSGPEVTVESGIIYAILLGLIILLRGLTGGIFWMLNYEAAARIKYGTLSLLYSKVIRLKSLRDKTVGDIVNIISNDGQRIWDGIILGPFIIGGPMILIMTCVYSIVFLGPWALLGWFIIIGFYPFAIVCAKFSQKYRERCIAVTDRRVGLMTELLTCIRLIKMCAWETAFSDKIADIRQEERSILERSVLVQSISMGSSMMVPIFASCLTFIGYVSTGHNLTAAQAFTFVSLLNTMQVSLATVPFAMKAVSEMIVTTHRIKEILIMEEMNAAEVLPLDESSAVEIENASFSWSSGRARKDMGNGIQDKPKHKKKGKKQPEQEAETLNSGSEGENGRIYTGPTLSNITFTLKKGQLVGVCGQVGSGKSSLINAILGRMEVTSGFVGVVSQVAYVSQQSWIMNDTVRGNILFEKAYDEDRYKQVLEACALPPDIATLPSGDLTEVGERGATLSGGQKQRISLARAAYSDCELILLDDPMSAVDVQVGQHIFQHYIQGLLKGRTVVLVTHQLQYLESCDEILVMKDGGLAEHGSHPQLLSNKGEYANLLSLFGDFRSSSKESLSHITDRGENGGTPNEENNNGSGGVVAHGSGPEVADQENGLNHADETIKATAEAKEQGKLIAEEEMESGSLEAWVVHQYILSMGGYPVVLFVFFCFCLPVVSVSLAGWYLSYWLEQGGGSVNITIGNMTRPSLRVVDNPDKHHYMLIYTMFIPILISTMFLRSFSLVKATLRASSQLHDKGFSGILHCPMSFFHSTPVGRIINRFSADLDEIDVRLPMNVEIFLNNVLQVIAALCMIAFVAPWFLLAAVPLGALFFFLMSMFHTCVRELKGLDNVTRSPVLSHAATSVQGMSTIQTYRRTVHFEKCHRDLLNTNCVAVFLFYSANRWLAIRLDIVSAAVAFATGLLVLLTFDQLNPALAGLALSYSVQMSGLFQFTARLAVETEARFTSVQRILKYCNITQEEPSLAVVSGQSLTSWPKSGGIVFDGVQLRYRSDLPLALQNVSFKVEAQEKVGIVGRSGAGKTSLSAALFRLVELDGGRIFVDNVDISTVNLKELRSNLSVIPQDPVLFSGTIRYNLDPFQQRSDADIWQALGKCHMALMVKGLEHQLDTAVLENGDNFSLGERQLFCLARALLRNCKILVLDEATAAVDSETDSLIQTTLRESFSQCTMLIIAHRLNTVLSCDKIVVMDNGKVQESGSPSDLLSNASSQFRTMLQASEVPFKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1F5</accession>
    <name>A0ABM1A1F5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101848048</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101848048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938893.1">
        <property type="nucleotide sequence ID" value="XM_013083439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848048"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045349601" evidence="1">
        <location>
            <begin position="17"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938893.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="41999" checksum="047C4B3FD418220A" modified="2025-10-08" version="1">MWSLVTTWLFVAAVTAYSDLRATPCMSDYLINKIPENRSVWSGEIQMVMECSRGYDLPLNAPPEGVFRCSPDRLPWKPSFIPDCNKEHVPRFLNLVLGLPMSVDRCEKVVSGRRSAPVSTNLGFLSNADDISSLCDDSGVLGGSCLVRNVTGFCSGPPRRASQDTDFWAQELGLGSSFLLIVLRTAYNTRVSLHKYMTAKDKVAKALRAKVGQQGGQTSDNIESLLKAECPKGSLGVERTESDKKIVCRGCSLGHRLDPRLKQCVPCPGGLYQDEPLSENCKVCPALFGMLNETLWAEIKIKVRGGVFSMTYCPSLEKREDGSVSLVMPRKKIGVLGEGNEESLSSLLEGSRTHGSGSSQLSLVSPVLVGSVVGVTLAALLTATAVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A341</accession>
    <name>A0ABM1A341_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Paired box protein Pax-3-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101846149</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939856.1">
        <property type="nucleotide sequence ID" value="XM_013084402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846149"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF52">
        <property type="entry name" value="PAIRED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="261"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="263"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012939856.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="63899" checksum="9B29EE459FCA88ED" modified="2025-10-08" version="1">MDKLQQLSNFPQSTHLARSALLDISHPVYPPTGSDVSRQPVLETRECLQRMWTRLCDPLTIRCSTIGGSKPKVATPSVVAKIEQLKADNPTMFAWEIRDRLLADGVCGQSNVPSVSSINRILRNRAAERAANEYAKLATQVLHPLYNTYWPGYPSVPGLPPQVRAATAQLSVPAQIKLATPAIMASTPNLKTSSAVCPPLQQSAVYADCFHLPLTSNTSVTSSSSDGEEERDGADTVSNDSKPVSASPVVSPDVIDREGLQKLRRNRTTFSSGQLEILEQEFSRTHYPGVATREALAGRTGLSEARVQVWFSNRRAKWRRHQRLKLLQSSAPYMFQFPPLHATGGGVCAEVPGHKAVSPPPALSHDEPRMCSFPRKPQSCPDNEATSNYQLKRARYREEEEPLYFTGLKQQQVPCPESPPIKPHNVGGINITEIGLQHDTMTTQNNLNFVNTKLCGVARISDSTDKPLDLYTNRISFESETDNKRSPEHTLMTSPAGVATSLLYQQCSPDVITTITTATTLSVAAATTTATKIQTSPKPPSFAISQHFAFQTTGSPQSSAKADGDRRCLITSHVINVEDNGVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4E3</accession>
    <name>A0ABM1A4E3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Caspase-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940622.1">
        <property type="nucleotide sequence ID" value="XM_013085168.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857194"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="10">
        <location>
            <begin position="257"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="9">
        <location>
            <begin position="424"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012940622.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="56920" checksum="442F3E9FAE643F41" modified="2025-10-08" version="1">MGDGLTYSRLIAGVLNQHQIEIAKTVDYEELRPYLVQRNVFTTLDLQVAEAKKPYFYTIIHLCEKAKTLDRKGFEDFIDAIAEDHYWLADKIRADYDEKLSASKVNQVKTSCPPGSTSSGMRLPGLSALQQKAPPHSRSQSANLAARAHDTQAMKPALVSVPRGGGGGSLTSSPQSRPPVSGSALEVCKEFKGASPRDPDMCLQDPEAERLVRASASSPRSHHSMGGISPVQRGGNNKYAEKRRKNPNSVYAMDSHPRGFVLIINNEKFDTLPERHWSESDRTKLFHMFKFLGFQVSLEENCNTAKMKELLQLFARFDRLKTASTMAVVILTHGGSNDLLFGTDGKVVHGTPIADTYITKFDLIQAFKPESCPSMNGKPKLFIIQACRGVEDDRPASAQHLSWPSQITTDGADTPSANSVGAAAVPHRAAASDMCFVHSSTIGYKAYRQKNVGSPFVDTLTKMVTDWARDLKFQDIIQEVQKSMAQQPLPYDNYTLPELSTHLMQKWYLNPPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A596</accession>
    <name>A0ABM1A596_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101847748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941089.1">
        <property type="nucleotide sequence ID" value="XM_013085635.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847748"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="10">
        <location>
            <begin position="68"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012941089.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16551" checksum="9BBD5888C62664A2" modified="2025-10-08" version="1">MSDTQRVLPPTAPPSYTESQFSPAPSVPTHQLAQAQTPSEAPPPYTPPTNPPYAEASSGYQRFEPVVVNQVEVLSIVRLGPDPCQVKCPSCQQQGLTNISYRAGVLTFLTAVLCFLFCIVCTFLPFCVSDLQDVAHYCPYCGYHIGTYTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A609</accession>
    <name>A0ABM1A609_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941515.1">
        <property type="nucleotide sequence ID" value="XM_013086061.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861831"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="73"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="658"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012941515.1"/>
        </source>
    </evidence>
    <sequence length="869" mass="94039" checksum="6CB7C91F43469745" modified="2025-10-08" version="1">MPVAERSRLLSGGSLEYDDNLHKNSIVEHKSNMETSLERYRNGKEKVPVCCSYRMGVIICCTCSMTVTFATQASMSSAMVCMLEDTDPGTYNLTDTGNTSHSINNYTLPGEDDPWKFDWDKTTQGWVLSALFMGYYISQLPSGVASARFGPKRVVVIGLILVSIFQVLAVPAARLGLGWLYADRAITGLIDGFLYAPTFALVGQWTPRYETSLLFGIVGMGMELGNMFSYGASTVSCEIDIQGGWPFVFYIMAAFGLLTSVMFVVLVSDSPFNNKFISKKEVSYIANTVPKMDDNDDTALIRIPVKEILKSMPVWAIVVSQIGSDWLYYMLISVGPMYLKDVIKLSDFEVNLLSGLPFMATIPAIYLAGYVCDKLVVNKVLTNTQVRKINDAVCKLIPAGVLLAFCFLPEGSTAAAAVLNTIAATALSFSYVSWMANPVDLAPAYTGFIVGVCEVGAVWVAIVVPIFFDSITINKERSEWQLAYYITVGLQFFSLFFYCVFASGELQPWALHTYKHKYEQLPGNNNDEDEDKNKQKMLGFSEPGTSYSGHSGSLDSVGEEKKKARKNDDLMATLAASLVETLPDVEADGLRDPSSQPRSRSNTQQAVVIMYSAPADDDVKLESGNNHPVDYKTSPSSGERQQSVSLLDEILQADKEGGVTPTTTVFSPSPESGHERQGQGQYNHIPFSPSGQAKFNNTNGDGHLITEAGHNVGGLNSDPTQQKLSSPSVATMQIHTSEAIGKRSDIDDVSPVSSVSSSSLPESATNHKGKGKGGKGKKSKGGKSSRSESSSSGGSFSGSNSSLNDKGRENESEAPTIRRRRAASEGKVDDSASPTVLVKPENVANGDGIHSQNSSSIMTPVNDSLATKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6V9</accession>
    <name>A0ABM1A6V9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein cycle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941990.2">
        <property type="nucleotide sequence ID" value="XM_013086536.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012735"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="50"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941990.2"/>
        </source>
    </evidence>
    <sequence length="115" mass="12899" checksum="80B19D45CCB07080" modified="2025-10-08" version="1">MERKRKKSTASLDAFDSDDEDDPQGRLSGQSSSCMDTADMDGRLPSLSPMTRQNHSEIEKRRRDKMNTYISELSALIPMCSAMNRKLDKLTVLRMAVQHINSLKGSSKVCSDVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7T4</accession>
    <name>A0ABM1A7T4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012942500.1">
        <property type="nucleotide sequence ID" value="XM_013087046.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861534"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="14"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942500.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16362" checksum="9BECCDE7E1B68B5D" modified="2025-10-08" version="1">MTSRGEAGPRRWLVLAMSFVNLLVNGSLNYHVGVLNLALLDNYHADPLLTSWLMSLYVSLFALGGPVSSVIIDMFSCRVCVFMAGVLGLVGMAGSYLVTDPAVLFLTLTIAGIGQSLSFVGGSLVLSFYFPDMMTIANGVYFCGAGLGTFIHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8N1</accession>
    <name>A0ABM1A8N1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TBC1 domain family member 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942942.2">
        <property type="nucleotide sequence ID" value="XM_013087488.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856533"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="216"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942942.2"/>
        </source>
    </evidence>
    <sequence length="591" mass="67771" checksum="10249C57302C717C" modified="2025-10-08" version="1">MQKDEIIEDLDEKLGSRSSGHDGYDSKKRVSALSKEHQERVRVLQNQNRFLNEEVRRLAKLRGQEHDKMRTLDGRIRGLEGDIEVWKLEYISLIQSSIRFTGSDTMDDAELSLFGGDRHKIRIMSLLEEARRINPSLPTYEHLASGEVHVDCYGFKHQFVDDGLLLHYLCQELSQHFLSQASSHEKHQKNWMIYLKNHAKGVAVNKKDLKSLVRGGIPDQHRKMMWRVFVMAQVEEIVSDKGAHYYRSLCNAVPDSPLAARYRKQISLDLMRTMPSNVKFSTPGSKGIMDLQDVLLAFCLHNPAVGYCQGMNFLVAMALLFMDAQDAFWTLVAVTERYHSPSYFDHNLLGAQADQSVLHDLMAEKLPVLTTHLDAIDIEISTVTLNWFLALFFDAVPFQTLLRIWDVFLLEGPKVLFRFSLAVLHLHSKEIVQKADTISVMRHLKACARISYDADGLVHVAFRTLKPFPRRHDIVSKQTFYLNALKEKYRWRDLQRLALQERENAFQSLDGDPESPRGFECCAVTRPGEAWVVYGSPPLSRICIVDCHEQTMTDTEIVFETRVLSIAAVPGEMVLLGTLDWCVYAYSQNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8R1</accession>
    <name>A0ABM1A8R1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Probable G-protein coupled receptor CG31760</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101852748</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942993.1">
        <property type="nucleotide sequence ID" value="XM_013087539.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852748"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15293">
        <property type="entry name" value="7tmC_GPR158-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12913">
        <property type="entry name" value="PDC1_MCP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF26">
        <property type="entry name" value="SMOG, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22673">
        <property type="entry name" value="MCP-like_PDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047121159" evidence="19">
        <location>
            <begin position="31"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="20">
        <location>
            <begin position="381"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="724"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_012942993.1"/>
        </source>
    </evidence>
    <sequence length="736" mass="81498" checksum="DC5E9250060CA266" modified="2025-10-08" version="1">MKSLTSHVIAMFGLGVWCFFCCGFLPLAQAQVTESSYAGASALDRIKAAKQALDYVRTIERTHNCTGGTEETLTLNFDHDRWMSYSDPAIRTANYLSKILAIDGDLSALGDDKFYALVRNNVHGGSLIFGSAIALEPDVIAGRTKFCPYAFRDNGSVRAFDIAINYDYQQDSTEWYHAVRISNLSNISVAVDRITIDDQDKVNGTIYLTQPVAAYPDGHWTYPYYDCGGGDIWMTTYSAPIMAQNSEAKVIFRGVATIDIELTNLDINQCDLDENEDSQALDVFRGTHNCQPTTQCVPLKEGFRSGAYLCQCKEGYYFPNTTASEKAFRGSDIDYFFETQNSIVRSQFGFVATQFQCLRCARGCDSCVDSRPCLYQINIAVQALVIFLVSAMILGCIVVSIITFTYRKELVIKTASPIFLQLMCLGAILMCSSVFVLYGEVTSLACTIRIWPYHLGFGVMYGALLLKTWRISVIFKQGGTMKRVNLPDKALLQRLVPLVALVVVYLGVWSAIHPPLAETVKTSKELKFFVCSMSWWSYAMFGVQALLLLVGVYLCFTVRKAPAHFNESKFITWATYNAIILGSFILMLTQFVGMSVGPDVVFVLHMAQQQVFVTITMALIFAPKFWALYRGSSNAEGRVYSNHVVTITGRVKPSLAPSSSRFSESTAVTTRQVAVQCNPDDFLLIAQEDDNSLKVPSASSSSNYMSKYSAKVSPACSEAESLRETNGTRPTSVSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8R3</accession>
    <name>A0ABM1A8R3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myosin-IIIa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942995.1">
        <property type="nucleotide sequence ID" value="XM_013087541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853642"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052838">
        <property type="entry name" value="Myosin-XVI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47335">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XVI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47335:SF1">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XVI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 5" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="5">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="719"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="811"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="827"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="898"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="928"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="951"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="979"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012942995.1"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115584" checksum="F594C3EB67F85F31" modified="2025-10-08" version="1">MLQPAIKGVLSLYIFEHFILQVNPLLEAFGNASTVLNSNSSRFAKYLTLALSPSGKVLGGQISEFLLEKSRVVSQGQGERNFHIFYWMLAGVTPEERNQCRLENSNFRYQKSQTSNLEPLVTPGVKAKFWEVKESLKYIGFSSEDVTCVLTVLSAILHMGNLHFRSRPGKEEQACLDDLKVLQIVCSLLRISEEDFHSALLEDVMIARGEQTHRPLTPDQSREAVDALSRALYSRLFSWLVNGLNQMVQAPPDSESASLSVSVLDVFGFENLAQNGFEQMCINVANERLQSFYNQRVFEAEMRDCMSEGVPYPDVVLPSADQAVLNLFMAKNCGIFDLLDEESKFPKATDESLAAKLHSVAGKSQQSVYKSPRYGGPTFTVVHYADVITYDLVGLLKINRDVLRPALTFVMRGSASLVVKELFQSQMTHTGSLSPSKRQRVSRHIKGAKSPFDFFKKLKMSKKDLQKKKDAKKKEAAQKRTGTTLTHHFKNSLSELMSKIQSSSCHFVRCLKSNRQQVAMTTDRNFLQAQLFYTGVNETVRIRQLGYPLRATFSQFLKLYPTLTSLSSGRPGHELVLDPVRTAHDLIQKYGVKGFQVGQTKIFLRQNEVLHLDVLEQTSLRKVILAQSAVRRFLAREKLEERKMLRQHYSSSLAQLCESVDQFQRQTDQTLAYLTGLDRDRQEQEMIRRPDQDEHAPLRGSAEYVQLLDMVLDEYSTPCTSAVTSPRQDPDDSDELDSVFLPTDNTTTPHPDLAGRLSLLPPPPPPPDTTTSSPSEDKHYDASADSYYHGADDKEVAAGTSSDGCYYSIASAFPDLRPSPHPPTDYDFVRREEEEEGKTSEEAMDPSRQFPPSPREMYNMQRGGHPMPLNGHMRSASPSRARAPPTLPERRPDTQLGNRNSTSSRTSASSDGTPPSSPGYVTHDQLHHQYHHQHHHQQQHHPHQAQHHQHIQQLQQQLQQQQQQQHHHQVPSHGVPAAHHPHHHHHHPHLPQHHQASVPAGGPHIYGLLHNPAAGPTVTFPHPPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8V3</accession>
    <name>A0ABM1A8V3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 15 member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101853668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943053.1">
        <property type="nucleotide sequence ID" value="XM_013087599.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853668"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012943053.1"/>
        </source>
    </evidence>
    <sequence length="691" mass="76217" checksum="4AADBED2DE9B7648" modified="2025-10-08" version="1">MSVSVFDTPMSSWYWKQKGECVTKERVIGINLRYMAEDGVFKKVSDSTKTMEGSGDTDSQGAAHEGSKPPLTVASNGPCQTDGMDTEFTISSSLKRRTLTAALVILFAQFMERTAFYGVVSNMILFCTSNLGFDTVNATTVSLVFLGFVYLFPVLGGWVSDSYTGRFYAVLVSGFVMCLGLLFALVAAVDFSDWFDHDLSEAGKRATFFVGLGLVALGSGGFRPNISPLGAEQVKHLGDSAVDTFFSWLYWVIALGSTLAYTGVAYLEQNISFVWSFLGLFCVLFLTQIIFLASRSLFNRTKPEGSVLRVFFSVLKQAFFTNRGNHWENSSQESEPPGHLDGARMSHGGSHDNVTVDGVWSVLKMIPICALIIMFWAIYSQMQTSYFVQAERMDVRVGGVLIPAAILGSFNNFVMVIMVPVLDRIVYPFMNRIGFPLKPLRRVGLGLLLATASVLVAAVVEIYRKEYMRAPGGSHVQVLANQNFTASSMSVFVQTPQFLLIGVGEVFLGTAILEMGYTQAPKSMQGILTGIFYFSGTGNFVSLGILRLVEWGTAEDPWWGNEINDIKMENLMFLLSGIMFINFLIFTAVAWRYTYSDVTKSPTSEAESDPGKTSTADQYMMYSDIATDAKPPALDSLPNIDLSRKNDNVVSNRYLWKEEDNHLSSEPFRAGLCSLETTENGMPGTKNNVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A950</accession>
    <name>A0ABM1A950_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013041</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943192.2">
        <property type="nucleotide sequence ID" value="XM_013087738.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013041"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF195">
        <property type="entry name" value="ENDOTHELIN-CONVERTING ENZYME-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943192.2"/>
        </source>
    </evidence>
    <sequence length="315" mass="36708" checksum="4F718F8069F07CE0" modified="2025-10-08" version="1">MYTSNQEKLETIMEKPVQRMTDWASERKLKQFFQACNDLYTREQLRGKPFLEKIVANVGGWDGIGTFNESTWDMNWALKKVQTDFWVDALYAPRIGVSWQDSSRRDIQLTPAGTGKWMYWSWYTHPYAEYMRQDYKKFIRRVGSLLQRDANLASMTDEEKGRRLDQFVNDTFTIEYNVASIARQSQFSYNHYLEANKVSLADLNTETNNVINWVDQLSYMFNAAGVNANTRVVLLQRDYYRNITGMITSLPDEDRKRMMSNYFIWRMAEIYVQVSSKRQCTTAGALTPPPSALWVLSLGNTYTTLSMSGANITIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9M6</accession>
    <name>A0ABM1A9M6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101854119</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101854119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943469.1">
        <property type="nucleotide sequence ID" value="XM_013088015.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854119"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012943469.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37473" checksum="40AAC6BE28CFAD43" modified="2025-10-08" version="1">MPLSSIVHITLLLKKSKTITLPRVSEVFTDNKSSVKEKNPRMKPLPRLLWTLQTVLLILQASYGQNLTPKEVIAIATKLTTPFMERKLAAESFTTRATDRLMDGLNDVTALLDSTHAELTGTVKDAAAQAKMARKGMERVVFDVTNIEEHLNQLHSTCPAGPYYLNLEKLEAMKQHASENSSDKMDILSLFRGESIRVVKPELGEEGKEVNEAEAEEKERKEMADLLQPTPDVTELVDSLLKKYGYEATVSLRDFLTVCRTIARGVERQRLAALQDRLTKAGKASRFVTDSTRHVRGLQSVTSDLRSLVGRAEVVLGSLPQVVKKVTGVSACVSAVGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9W6</accession>
    <name>A0ABM1A9W6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106013168</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106013168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943628.1">
        <property type="nucleotide sequence ID" value="XM_013088174.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013168"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012943628.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24328" checksum="4D5E3E433E8CA6CA" modified="2025-10-08" version="1">MIPRHRAKPAKRGRQLVVLEKSENPRLSQLVLSNPVNQAAHWSQESYLLRDLHKQYPLPQVVRCSSRLVQGEEQALPVNVHVPMLLCDGRSVRKLLAKHVDNDTTSQSLVETDDSIVIPGDYDGNFLRLHARTTQDKSVACSLHDVANSQIPAFVNFSSITSYTNLSPNYQDGDLGKLSGSTNNLGSEFSSSHVSSRAIKINDRSGQERQNVGICEVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA91</accession>
    <name>A0ABM1AA91_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Perlucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943835.2">
        <property type="nucleotide sequence ID" value="XM_013088381.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850205"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046764709" evidence="2">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="35"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012943835.2"/>
        </source>
    </evidence>
    <sequence length="172" mass="19107" checksum="7FFB0FB084FAAF9D" modified="2025-10-08" version="1">MSRRHNMFRFVVAAILLVFASAERKTTCPPGYDKVDNFCFKLLSEKLSLFEATTACDVIDGKVVEVTSQDEQTRVSQYLSKVAGTSPSDMHVWLGATDLQVEGTFLYMSHSNEQAIASFSNWAPSHPSKDADSNCVSLSYTAGWAWEDVPCTYHIPVLCYVHLELEQDGIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAN9</accession>
    <name>A0ABM1AAN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101850038 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944080.1">
        <property type="nucleotide sequence ID" value="XM_013088626.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850038"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18376">
        <property type="entry name" value="BTB_POZ_FIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="342"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944080.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="50644" checksum="2521CB49C476ABEF" modified="2025-10-08" version="1">MSAATVTISIMPVRHHGSINANWISIMNMPNQGARQVFLYDHGRPHWSQGGPLFYDRRVPPPPPPQMGNFPNPQIQGPSPQWLRGPFIGGPGPGPGPNQQQFDGFGIIPWGNQGNHNYNRGVLYVIFSRHNNRHHHNRNGGAPRNNRLLALNARGNNHRQQHNNNDHEVRYLCFKCGDYLQNSPESGVHLCDAGGPHLEQRQSHQLHNNNGGELQQQQHEDLQARLKAFMEEAKVAVSSDVKLSQEDIHKVCLERAEKFLSLYNQLQNEQLSIQEQQEKLEAQRKELEKRDGELAALQTQLEDDRSKLLKECKKEREEIARKWQELKDEISRMEEMHTMQKGRIRLDVGGSVFTTSRLTLTKDADSMLAAMFSGRHHVTQEEDGTVFIDRDGTHFRYILNYLRDGGVNPDGLPRDRQVLRELRNEAVYFQLNGLVQTIEKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABZ5</accession>
    <name>A0ABM1ABZ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flocculation protein FLO11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944802.1">
        <property type="nucleotide sequence ID" value="XM_013089348.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013478"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944802.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43584" checksum="40A58657FCE9F3AA" modified="2025-10-08" version="1">METSGALKLLQKLLEAEEDNEDVTENDCEEYNNAVSSVPSSLDPKTIIASLISRANSVLSNGESEHADSSMSDDDGDDPDYVPTTNTSLLTENDSFTVTENGSPSVKTNQNALVTRSPASRPSRSQDTDTSDTTGPAPRPGRSQDNDTTGPAPRPGTSQDNDTTDPAPRPGTSQDNDTTGPAPRPGTSQDNDTIGPAPRPGTSQDNDTTGPASRPGTNQDNDTTGPAPRPGTNQDNDTTGPAQTNPKKRQRNPYQWKKNVRKSKIAKGEAYTTKTGKAMPARKTGQNCKCRLKCFQRIGEDHQDKILQSFNDIGNKQWQEIYLHGCIDMHAPKRKRSRNGERENGKDSKCFTCEYSVTPNGVKLQVCMASIHSPPWHWQDSSEKDKKANNYGSPQGHAWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC06</accession>
    <name>A0ABM1AC06_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101862907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944825.1">
        <property type="nucleotide sequence ID" value="XM_013089371.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862907"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012944825.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13184" checksum="0C60D2AD8BDBD3A3" modified="2025-10-08" version="1">MGAKKADPKASGKGGKTSAKPKKEGSGGKAKKKKWSKGKVRDKLNNLILFDKATYDKLYKEVPSYKLITPSVVSERLKVRGSLAKQALRELHGKGLIRLVSKHSSQMIYTRATKGDKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE12</accession>
    <name>A0ABM1AE12_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ras-related protein Rab-27A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101864042</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945898.2">
        <property type="nucleotide sequence ID" value="XM_013090444.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864042"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04127">
        <property type="entry name" value="Rab27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041837">
        <property type="entry name" value="Rab27a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012945898.2"/>
        </source>
    </evidence>
    <sequence length="241" mass="26552" checksum="8C6DAE703751C437" modified="2025-10-08" version="1">MGEVGERICSPGPGGGNGPADYDYLIKFLALGDSGVGKTSLLYQYTDHSFNGKFISTVGIDFREKRVVHRVPGSDGSIGRSHRVHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEDSLLNTRNWLTQLQTHAYCENPDVVLCGNKSDLEDHRRVSEDRARDMAEKFGLPYFETSAATGQNVSKAVDCLLDMVMSRMEQCVDQSQLPDVDNGQPRNRASLTQRPGGSQSAGGEGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEG2</accession>
    <name>A0ABM1AEG2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101851240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101851240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PDGF/VEGF growth factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946121.1">
        <property type="nucleotide sequence ID" value="XM_013090667.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851240"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004153">
        <property type="entry name" value="CXCXC_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11633:SF1">
        <property type="entry name" value="LD28763P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11633">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03128">
        <property type="entry name" value="CXCXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00141">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0339">Growth factor</keyword>
    <keyword evidence="6" id="KW-0497">Mitogen</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046492125" evidence="9">
        <location>
            <begin position="23"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="10">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012946121.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43035" checksum="2D577884BA6C2893" modified="2025-10-08" version="1">MFMRSLFSYICIIALLLLKVQAESKNKAESNNDDHYEDSGEKEYPIKLVKRQASDYPSSLRADFNATLRNAALMQLQGVESIEDLISRGIVMNNGRPLTAEDLSASYDNATGKMVIAGGGELAEADECSPREKNVEVNLGPIYANIVVFPRCLRVLRCGGCCNVPALVCRPRYEERKIYNLLQLEPISRSGHLALEARGTYPVEVVRHMSCSCECTLTTASCGPRKRLNRNQCRCECRRMARRRRCHVPKVFNPETCRCECASRRRNCCRNRRTCALRFNENSCRCELDTGSRPASSPFFPSPAPQSSANNQAGSSNSSQTARPVTSPTATMTLSTIPPAQSSSPTGLCNCPGWLQPRITETGQCTCTPSGDTRRRGRPLHARPRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFS1</accession>
    <name>A0ABM1AFS1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946782.1">
        <property type="nucleotide sequence ID" value="XM_013091328.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846628"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012946782.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11660" checksum="3105E8622818543C" modified="2025-10-08" version="1">MMSLSLSNASAREWFSKTRESVRPWAEFVHTKRFGVPKSIAPVPKRIVKNIDTFQGNYLFVFMGLVVFCILTSPLLLVALAACFGACYLISVKNQDKKITVMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ28</accession>
    <name>A0ABM1VQ28_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035824520.1">
        <property type="nucleotide sequence ID" value="XM_035968627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860727"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF278">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044984520" description="Carbonic anhydrase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="279"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035824520.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="63035" checksum="E12B7C26D5DD5C74" modified="2025-10-08" version="1">MILSVFCTLCLLVGSTRAASGWSYSGSTGPAFWKDVSATCDAQRQSPINLYEGDAVQNPFTPFTFTNYDATSGFNATLKNNGYGVKVDYSGATELTMQGGGFTDTFKVAQFHFHWGRTSVQGSEHLISSQAFPMELHIVHYNSKYSDLGEALKHADGVAVLGFMYEVSASDNANYADLVNNLSNVQSQGSKIDLAGFALNTLLQNSFSNFFRYDGSLTTPDCQEVVTWTVFKDSIKISESQMEKFRNVMDGNGNAIVDNFRPPMPLNQRVVQSSFTTGITWGYASNVANAGSASKWSEYYGHCVDDAGSKQSPIDIDPTTVYLDKSINTFTMSGYDSAQGVNMQLKNNGHTVQVDITAGDIRMSGGGLPGEFKAAQFHFHWGSDSTKGSEHLIDSAAYPMEVHIVHHHIQYPTLTDAVAQSDGLAVLGTMFEISKEDNPALDPIISKLTDISDPKTSTSMDTVRLDTFLPADITEFYRYSGSLTTPGCYESVTWTVFRKSIPISEAQLAKFRALLSADKNAAGTYTKMVNNYRPTMNRNNRRIVATFLIGYGERVTYSAVSLTFCMLLAAVQRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ83</accession>
    <name>A0ABM1VQ83_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477371</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824575.1">
        <property type="nucleotide sequence ID" value="XM_035968682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477371"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035824575.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24680" checksum="020EF5B924F42E69" modified="2025-10-08" version="1">MLRDSVIQGSLIRNVLTLTVGWDPYSASSRTVVSNYVVIPEPKITVRALTPLTQPIMGIFKTHVIHESSRQFLQAKVECLTPYENVSNEVMLTVQLMEVSLTNTEGISEETRELLEDWKGALTSTLGSYQNNKAILQLPRIPLDSARHDNMTVTSTFRVRVEDYSDLKDGAMYEVKLATSFRDVILWAGLIPVTLDAPDVRMPDLWVSMSQAALCSYDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQW1</accession>
    <name>A0ABM1VQW1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-coumarate--CoA ligase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118477436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824803.1">
        <property type="nucleotide sequence ID" value="XM_035968910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477436"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="91"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035824803.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18699" checksum="12C45587B7ABB870" modified="2025-10-08" version="1">MRSLVLRSLARISRQQFCEGNHAPASFTGSLHGNFHGVSNPTAAGSQNYGCREYSSGSTPIQIVSPDNIVRSPLPDVELPERTVHEEIFRSCDLNKDLIAVEEFLTGKSITYGELKERAIRVASALSGLGYSKGDVVLCYSINNIETAILTLACSCLGVWFSPANGTFTPGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR09</accession>
    <name>A0ABM1VR09_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118477447</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824851.1">
        <property type="nucleotide sequence ID" value="XM_035968958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477447"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824851.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19928" checksum="24CADF60C87DAFA0" modified="2025-10-08" version="1">MSKNTVKESRSETATGNLSGFSGSSSDVQHQERVDEITQANRRIKARDVREMLGISVGSSQCIIQDVLGYRKVCARWVPHMLSPELRLYRSQVSDELLARYNDEGDAFLSCIVTGDETWLKEYLKGKCYADGDEVQKMCVAGSVENHMNFSPTACDNLFDVGGSALTKKATMLKSKGTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRW8</accession>
    <name>A0ABM1VRW8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Toll-like receptor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101847817</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825160.1">
        <property type="nucleotide sequence ID" value="XM_035969267.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847817"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="801"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035825160.1"/>
        </source>
    </evidence>
    <sequence length="943" mass="106218" checksum="2D2815AE5B864CBC" modified="2025-10-08" version="1">MAQGKHCSRRDCTESSLLQSCRLFCLLDTFAPAINGDVSRDDNGYVSRDVTGYVPRNVYGDMSRYVNGDESHDVNGDVLHDVNGDVSRDEQSHSSCVVFQEPEGAVVDCRSEALKEVPTHEIPQSAVKLYLDDNSIEALHDNCFGPLPHLKVLTISRNKLKLISGCAFCGLAGLEVLNLEKNQLDLNASMWENEPFRGLSQLTTLNLLDNESGFCQCEFHSRLLSGLHSLDILSLDTFNGNLTFGELFANMTSLDHLILSGGVSTLVNNSFQSLQSLGLKALSLNHLHKLHTTELDAFQHLPSLQSLTILDNDQGVEGTLRSLHPFRNRSMKTLYFNKIHISTFEKGRAKCSDSVVDAFKVEFLSQICVERFSLMNSGVTTVESNALRGSLWRKCVKFLDLTGNPLIGDRVSFLQVMGLKALRVFKISVTDRTTLKRSDNNSNKRSKEFRGSLKEGLRSYKPNSDKRLPVRAVHDPTTPMSLPSRFVPTDEMEGTVVRLRIPKTLIIFQVENVFHDGSSDTIFKRIIFYGGENLREMYFSGNDFFDFSGFIKGLRNVHVFDISFNDCSKMSRTIFQPFPKMKYLKMKGSKLDSMFMSRHSEQLFQPLTYLKYLDLSDNQLNHLAGGTFRDNSQLQTINLANNRFTAIPLDLTVLPNLTDLDLSGNSISQLDQKDMQSVEQHASMFMEFSLHLSGNILVCTCSSIQFLAWLQNTKVNLDRPMTYSCLTEDGTLTTTADFADIRALWRKCHGRPALLLSIILLCLMSLGFVITILCLKLKTQLKSFIYRIFVQNFVLHGPADYRHGVFIGYADADTRLACFTLRDFIQSRLGLSTYVMDINLLPASDMAESIVDAVSSSWRVVLIVTSDFLDRELWSYFTMTTAAYTVIPSNPGLIVVLLEETVHHRLPASLLRVLEEDSILSIPPSRRLSHEHMHRLRDLLQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSL6</accession>
    <name>A0ABM1VSL6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-gliadin MM1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825408.1">
        <property type="nucleotide sequence ID" value="XM_035969515.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011632"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047357433" evidence="2">
        <location>
            <begin position="23"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825408.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23251" checksum="4A1C822DA0E9D3C6" modified="2025-10-08" version="1">MDRRCLYVILMLEGLAISAVTGANSEADENAVDSPNYYYDTPDPVYLPSEKLYNQPQAPTVIYLPQPSPYTASQTPVNTNVIPQPRSYFAQKQTYYQNPKPASTYLQQITQLQQQQQRKQQQQQQQQQQRQQQLQQLQNVNTNAASLCGANACAVGTVCRVVQLCTMCSPLAVCIRPGTLPAEVGEPRQENVRRDTLQGYTWWPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUT3</accession>
    <name>A0ABM1VUT3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Xylan 1,4-beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101862734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826175.1">
        <property type="nucleotide sequence ID" value="XM_035970282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862734"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF42">
        <property type="entry name" value="FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="4">
        <location>
            <begin position="615"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035826175.1"/>
        </source>
    </evidence>
    <sequence length="706" mass="78465" checksum="95267719CD1E8C6F" modified="2025-10-08" version="1">MEGQKITFRVKFQAFQVVFLSQVVKLQCKFTHSLLASLDSTDVILSVANATGQEVRAKHNDFVKRGIFATHTGASCFSPVINIMRDPRWGRNQETYGEDPYLTGVLVQYFVKGLQGPGTKYIMTSAGCKHFDAYAGPEDIPVTRFVFDAQVSDTDWRMTFLPAFKKCVEAGTYSIMCSYNSVNGVPACANKQLLTDILRTEWNFKGYVVSDQGAVESVIWAHKYRNNSIDTVAACVNAGTNLELSSNLPVPIYMSMLDAIAQGKLTEELVRERVKPLFYTRMRLGEFDPEEDNPYAQLSMDQIESAEHQQVALTAAMKSFVLLKNEGGILPLKKGDFSKVAIIGPMANNTRQIFGGYSPKQDPSFTQTPLDGLRSLYPDIKYAQVCNDGTPCTKYDKVVVPSIVDDTELVIVALGTGPQVAGEARDMVDVELPGYQKASFFKTKYVIRHSSEMFSNPGTHVLLVELVNLDVTLSLKLGGSAKIILLLFSAGPLNITLADESYRVPAIMECFFPAQATGQALYNVLTNTGPDSSPAGRLPSTWPLYSSQIPPMVNYSMEGRTYRYFKGDPLYPFGYGLSYTQFLYADMTYFKNVKAGNDLDLQLAVTNVGPIDGEEVVQCYISWVNESLPVPQLQLAYFTRVFIPSQQTRMLSITISGESMAFWRDGQWIVELGDMYLYCGGQQPNQKRRAPSNVLSDSFTIISRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVR4</accession>
    <name>A0ABM1VVR4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101848441</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101848441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826506.1">
        <property type="nucleotide sequence ID" value="XM_035970613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848441"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047360613" evidence="1">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826506.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21637" checksum="A3E79944DFB7434A" modified="2025-10-08" version="1">MQFLALCLLVAPVAYTLAAPDPTTICLPEKSTMRVFGLIRKIQANVSSDFSQNKIAEVTELERRVLDLNTNYSYAIDPTGACTRQRLPVPGIITRCLPPSTVFLGTVFEGFVNKVSLNGWLIPVNQDINVTLLTYTEPGQSDSYFVLRRDDTSWGQRISFVSNPVASIADTSVFNVPAVCPDKPLEVRLNVFKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW35</accession>
    <name>A0ABM1VW35_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclosome subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101850733</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826627.1">
        <property type="nucleotide sequence ID" value="XM_035970734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850733"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28672">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28672:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046767741" description="Anaphase-promoting complex subunit 13" evidence="13">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035826627.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10148" checksum="CB506EA89A1FC99F" modified="2025-10-08" version="1">MCLQLALLILICAIMDSEYQRDGRLMDMIDEKWRADQLPMEDIEVPVTARPEPEQDNGPSTDAQHEHEHKWLDLALSSLNSMPPTSTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWU7</accession>
    <name>A0ABM1VWU7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">ATP-binding cassette sub-family G member 4 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC101862516</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103124.1">
        <property type="nucleotide sequence ID" value="XM_005103067.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005103125.1">
        <property type="nucleotide sequence ID" value="XM_005103068.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826889.1">
        <property type="nucleotide sequence ID" value="XM_035970996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862516"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF78">
        <property type="entry name" value="ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="49"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005103124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005103125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035826889.1"/>
        </source>
    </evidence>
    <sequence length="719" mass="80637" checksum="29267DE8E902BAAD" modified="2025-10-08" version="1">MAELLSVQVQIPTHIGQFLKPETKKLLPENGQREKSGGFHLRQHKPLDMKFTNVSYTVKDNHGSSKANKTILKNISGRFMSGELTAIMGPSGAGKSSLMNILAGYRTKNVTGSIVVRNRERDLRSFRKMSCYIMQDDELLPHLTVEEAMMCSANLKLAESTEIQHKQERVDEILEILGLQEAKKTRTLNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSVSCFQCVSLLKKLAEEGRTIICTVHQPSAKLFEMFDHLYLMVEGQCIYRGPVRSMLPYFESQGLVCPNYHNPADYVMEVASGEYGDEHVRRLIGAVASGSCEPCQAEFDRKHSSSERSQTPSVHSCEDDSTSNLSVVHSVKMAAPASSSASGTGTGTSAETTSLNLQERYDNRSMANGHPPPSPSSQKTNGMCFPLYKQKEQGDSAEDLPADQECHTFNTSCLTQFRVLFMRTFMSIVRDATLTRLRLISHLIVGILIGLLYLGIGNEASKAFNNAGLLFFGMMFLMFTALMPTVLTFPVEMSVFVREHLNYWYSLKAYYMAKTMADMPFQIIFSLVYGSIVYWMTSQPNDFMRFVMFLTLSTQTSLVAQSVGLLIGAATSTQVAVFLGPVTAIPIMLFSGFFVNLETIPNYLQWISYISYVRYSFEGALQAIYGLDRGDLDCDENHCIFRQGEDVLRLMDVEDAKFHVDFIILCAFFVVLRLGCYFVLRWRVKSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXY9</accession>
    <name>A0ABM1VXY9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (cytosine(38)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.204</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA (cytosine-5)-methyltransferase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.204" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035827282.1">
        <property type="nucleotide sequence ID" value="XM_035971389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860835"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035827282.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="60617" checksum="BBDF8037282DD5EF" modified="2025-10-08" version="1">MATMVSTMQPKCLRVLELYSGIGGMHYALKESGADFEVVMAVDINTSANSIYKHNFPDTDLHSFGIEKLTLKRLENMNIDAILMSPPCQPFTRVGKKRDCDDVRTKSFLHLLQLLRQLKRKPNYLLLENVKGFEVSLTHAQLMSCLDDCGYHYQQFLLTPLQFGIPNCRLRYYLIARLDQPFSFPMEKEIMTTLPRVGSPVGVSSAPVTSSESNSCSPTQELQGSSGVSVGVDATVSSQQSQVNDHDNGNNNSEQTHRVGDSGDDAPSSSQTVGDRVCQEVCGSNIDSGTSEVCSAKVSRLEVEKDSSDRSQGQGNNWDQTYHTATSSCDRSNNTKIDGAVETGPGDNISTRLCAQDCDSVSDIEALKQAGRNMRYCEEEDPLIGAHSRPLSQFMEQGGEEDFSQYLVPDRELHMFVVMDVVFPVLKKSTCFTKRYSHYIEGAGSVVQMTTNVQDVAAACEFKAKAVKMKNRSEWGTKELQILRNLKLRYFTPREVANLLCFPPEFDFPAGFSPLQLYRVLGNSLNVHVVARLFALMTRTVSAQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYA9</accession>
    <name>A0ABM1VYA9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho GTPase-activating protein 45 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101848906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827402.1">
        <property type="nucleotide sequence ID" value="XM_035971509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848906"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057028">
        <property type="entry name" value="RHG29_45_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24235">
        <property type="entry name" value="RHG29_45_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-BAR" evidence="7">
        <location>
            <begin position="245"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="673"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="963"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1191"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="963"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="998"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1191"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1236"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1284"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1337"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1362"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1408"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1434"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1514"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1550"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1596"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1634"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1650"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1674"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1747"/>
            <end position="1790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035827402.1"/>
        </source>
    </evidence>
    <sequence length="1802" mass="193246" checksum="1CEFF5E9419F64AC" modified="2025-10-08" version="1">MSSKGRQIAKSIGKSIKRKFEADFFQFPFGLEEQQRDLIFLPAPPFNTSPHGSPPLSVRKLMQQKMQSLPSPKKSSSLGTIATGDQQNPGMIDHDEIIALTHDVKKFSDSLAKLKLLFTEGIDPEEDVRVVIHEGLGEVLSVLNPVMQHYQDLQSPDIFTAARNLITMIKDHDYEGEMSAVDVQGFCEAIDQLALAFSSSVSEYLMGDMGPQMVMDLKTKSMNNIAVAEGDEHMDDHDADMISSEELDSILVSLDTGLTIALQRAKVWSKYLLDIVTYIEKKAQLEIDYAKNLSRVAHSVQNSLKKEGFLPLQSVYCTALSQDVEFASNLQATQAVLHSHKFVEPLSSRRMEHDKVYKSVKDVWHREYRRMSDSVTNLRKAQALYHSRQQDHERARDLALKADGEKVEKRRKAEEETLHKAAEAETTYKACVAEANYRQQELFKVKKEQLARIREQIQLCDQVIQSATVEYFQLYHTVISPIPVQYQTLSDSSKSYEPGSQYAEYIRRLPLGSRHVQPEVFVFEPYVHGQKASPEGIRKESFHSNGSMADPLHSPEGSPTTSPRRDKYRIPVKAWGQQPHGTGTSDTDSNSCSSKSHESSPSGSPHRASRRHLISSQSLDELTEEEILAASAQNGQEKRSQMKRTMTLGGEENLDIPGLLMHHRGRRNTTFGVDFQEQVDTFQTTVPPIVSKCLMEIERRGVMIKGIYRVSGVKSRVEQLCQKFDIDPEAVDLTDIPPNIISNVLKLYLRQLPEPLLTFRLYSDFIHTAKENMSGQLLGDNLVAHLKTLVAKLPSSNLRTCAVLMHHLQRVAAHADLNHMSASNLGIVFGPTLLRPLEGSASLASLVDTPHQTRAIDLLITNAHVIFGPSEDFQVAPSQTPIEQLNQALDGVLMPGQHLADHAQMQKQKQKSPDVSSQAESQAAVVVSEPAVPSAASSATQPCASEYLLPGSVSQELQDCQNLSVNVPGTSGTSTAQPATEESSSTPQSEPYLKKPTVTKSASSPLVSHRTYPSQMMTSSASVPGASDSSGTDMASALSSAASGMAASLLRSSSSFTSSQLSSTLGYHSLTTSASTGSFSSQDLETRGMSKSPVPMTEEVAKLSVETKPSGEEGNTECSAGEKQKLEELARKKAHSHQLENIKYLTKAPSVEETGDNFYPKINLVSSGGLPVTHSLPCMPKMNVVPADAVVDSSSPSHTETTTAVTAEQEPVPVSTTDQPVQNVPEAPPPPPPPSSSSSSSSAAPNAAATGKPSAVLRQPMVDNRGFSSRKSVLEEMPIPTVSKPMSPTSDGSETGGAEEGPVPAVTLPASPTIKRREMPSRIPTSPTIPRHGMGAKRGDKGDKRADQFKLEQRKLVMAIKSDAKITGPEDDKKSESDQVLVTGAVSPRASTSSSPKVKRKSGLFDDALSGGCALSASSHMVPQEPKPTPQSAEEVKPKTESPQEVEMKMECEEKLETPKESCAAQQGMFSPEVKKSTTKASGSPVSSRSSASSHTSVGQSKTGARSKSDTSKSDGQSSPRQKTSTISEGGVRPGVGRGRALAMPSTVFTKKSSPASSPGKGSPKVGSGSTPSSTRPLSSPAACSLTKRTAADQNSSPSSTRASTSSSAKQSGEGSSPSATPKSGSPLAKKLSGRSTDSPAAFSTRSTLKSSGSGPKTGSPPKGDVAARVERFSSSSTSQSSSSSLSSRQRKPSGEGVSASSSRTPTKPVLRKTSSGSSGGAVGSSGSPRRIHERCQQEKPSPSQTTGKSSASSAGKTSSSRPAQLSSSTTTATTATSSSSPVTTPTSTTGKLSQDRTPRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZR0</accession>
    <name>A0ABM1VZR0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118478424</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118478424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827903.1">
        <property type="nucleotide sequence ID" value="XM_035972010.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478424"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005049">
        <property type="entry name" value="STL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362:SF0">
        <property type="entry name" value="EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362">
        <property type="entry name" value="GLYCOSYLTRANSFERASE STELLO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03385">
        <property type="entry name" value="STELLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035827903.1"/>
        </source>
    </evidence>
    <sequence length="633" mass="72699" checksum="2A41BB9318EA8468" modified="2025-10-08" version="1">MLQSFYLNQTSSGLTYAGLSLFNPYKHFGQSTLWPRGFPLAAVGSPQEAVYRLSDDWDTPLIQQGVVNGDPDMDAIFRLTRKRTTTPLDVHFDPKAPPVFLPEGVFSPFNSQNTLFHYSAMWALLLPTTTTFRMCDIWRGYWAQRLLWEIGGHLGFFPPNAYQTRNSHSYMADAEDEKDMYFDTDRLLDFLTSWKCPHELSFFQCVHKLSSDMAKDSFWAEEDVEITRLWLEDLIKSGYPEPSRVNVTSAFSQLSPVEQKIVKKMSRAIPRHNTQAAEENQPSELDLKWAVTTRRGSYVYFVAVEQEPPSVLTSPERQQDREGRVSRHLSQVAALCTAIPAFTTRTDLINSHKTSAFHDVLLIVTFNWPFYENVRYIEIMHRNLFPNIVYCGVQAEKFARDTKDIGRELSFIEAPIVYGHRGYRCTINAIQMAYNVTGYLAVGDDVILNTWKFRDLDKQKLWMTKPSIFSCQTGTNWYWWDRPGGKTELTNAMASLRSKSETAATATGEPDIRAFFSQLQTNTGPNNGCLHGLSDVYFIPRHLSSRVTFYLKHFAAHNIMLELAVPMTLQGMQSRENIIILPSTNLWLQNRLNPWIHYSPDIYLLHPVKFSNLTNLAPLCSLHLTQLLLRSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W065</accession>
    <name>A0ABM1W065_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgin subfamily A member 6-like protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828058.1">
        <property type="nucleotide sequence ID" value="XM_035972165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478478"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031650">
        <property type="entry name" value="CCDC73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28660">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28660:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828058.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41575" checksum="48418821C378668C" modified="2025-10-08" version="1">MSLRVIFFPVRAPSSFVCFNMAEQSEVSSPPEDVTEVTDNATVHSDSQTEEPKEESVCEEGKATSCGVTEEVDTSRPVQQTEQLKKTTLFTPADLFRFRQLLVSTTEKLRRLETAEEKNESRIQELVVSNHTLNREKEDLLQQLKLKEQEYEQRLEDLRHECEDRLHRADVDKTSSEVKKKVTKEMQNRMKEELKQMQVKAYQQDKQISELQSQLASHHNSSDVALAHWTQMDVRLKELGGQYLKAAESLARLERGVDFARQVAKGLSYQVRHQQCEMRERTGQLVSVREEVIALRAQVTSRPVESFQVEEMRAQVEGMSRRVEQLEREREELTKELSRQTQRAQEALSSSQRAHEQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0B3</accession>
    <name>A0ABM1W0B3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101857596</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828106.1">
        <property type="nucleotide sequence ID" value="XM_035972213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857596"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828106.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39374" checksum="9DCB281CE5A8DCEA" modified="2025-10-08" version="1">MCGRQVIYNKAKEAKQSKLTKQQTLSTSEELRLSWRQGKPQRKHVKKAGISSWKRSKWFYVISGNCVLRYRKKRLKVSLLKDTFEPSYRKWWTVILRCFIQNQTGNEPKKWDRTGLVTEVLDPNQYVVKIDGSGPVTRRNRHRPRRAHKKLAEDSIPQPTKEEKRKQQCAAYRARIRADPLKHAEYKDKNAARKRLARKKATPEDKPVEREKARLRQAAFIKQHQKAKTAATSDGNVQVGRPLETRADARKTEERRAKNHLAQQKRRANMSSQKKRRERERNRAYLQRKRDVPLPKTPPAQESAPSTGTTSEGKGCRDLRRQCAGGKASRDPGRRQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W338</accession>
    <name>A0ABM1W338_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Low-density lipoprotein receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101845891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829081.1">
        <property type="nucleotide sequence ID" value="XM_035973188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845891"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046453680" evidence="10">
        <location>
            <begin position="23"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035829081.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29429" checksum="3AD25609BD903E14" modified="2025-10-08" version="1">MANSKVAIWALVLLSVANFVRPECQKGQIRCQRTNKCVWKRNLCDLKNDCGQWEDEMNCGFNSTRCSAGELECPDRMCIPLSWRCNGARDCADGSDEAGCDQCLPHQFRCTDGSCLNTDFQCDNERDCSDGSDEDGCIRVICRPDQFECANGLMCVPLYWVCDITPHCSDASDEKGCKACTKEHFMCSNGRKCIDPSQKCDRNKDCDDGSDEIGCFVSVPVTEEVTTTAPGNRGWRVVSSSSAVVVIALSSVVAGPMLLRVPAAPVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3I9</accession>
    <name>A0ABM1W3I9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Voltage-dependent calcium channel type D subunit alpha-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC106010959</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035829232.1">
        <property type="nucleotide sequence ID" value="XM_035973339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106010959"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="544"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="15">
        <location>
            <begin position="936"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="54"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1081"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1475"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1081"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1118"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1131"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1154"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1197"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1315"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1352"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1475"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1487"/>
            <end position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035829232.1"/>
        </source>
    </evidence>
    <sequence length="1532" mass="173439" checksum="23518006CAB2DDEE" modified="2025-10-08" version="1">MYDGIRAYGGVQFPGILVCLYFVVLFICGNYILLNLFLAIAVDNLADAQSLTEIEEEKEEEKERTRSLRRSKSRSPNKEQEGNEEEGLDVNGNDNNENGEKDSNHLSRQPSSRSRRSYRKEGSPGEHHVRLDLSPEHTSPGEYRNSHKIPLRDEEENNEETDEEGTEGTEDEEGEEEEDEDDEEAPSSARPRRMSELHISSRVKPIPPFSSLFVFSPTNKFRVICHKICNHSYFGNVVLACILISSAMLAAEDPLRSESQRNQILNKFDYFFTSVFTIEIIIKIITYGLLLHKGSFCRSLFNMLDLVVVAVSLISFPLDNEAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVALKTIYNIILVTLILNFMFAVMGVQLFKGKFFSCTDESKLTEEECKGEFITYMGGDYNAPQVEPREWIKNDFNFDDVMNGMLTLFVVSTFEGWPGLLYKSIDAHTEGMGPIQNYQPGVAIFYFIFIIVIAFFMMNIFVGFVIVTFQNEGEQEYKNCELDKNQRKCIEFALKVKPVRRYIPKARWQYKIWWFVTSQAFECGIFILIMINTIALAMKYYGQSTSYSDALDYLNVIFTGVFTVEFILKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIIYAEVNPGKAFISSNFFRLFRVMRLIKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGRIKLDYETQIQPNNHFQTFAHAVLVLFRSATGEAWQDIMLACSGKDDVLCDPSADPAAGYKANSTGPPPSCGNDFAYFYFITFYFLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFVRHWSEYDPEAKGRIKHLDVVTLLRKISPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTSLKIKTEGNIDTANEELRAVIKRIWKRTSTKLLDQVVPPAGDDDVTVGKFYATFLIQDYFRRFKKRKEQMVKIQKGQEHTNALQAGLRAVHDLGPEIRRAISGNLDEEEMLDKDVEEPMHRRNHTLFGSVMNAMAGVRPILPFLNRTQSLRGASKGHQAPNLGPIIAVSTAATEMLGMNGNIGSVSSCNHLNQDSNHSPSAPQTLTATQDDTPRRPSKTSESPVKVEPDEPSFHDAEEPEEEEEEEEEEDEEFVEDEGEEVGRKGEERREPEREDREDKERAMERSEREKKEAERGCGEGTELDSVVSPSLSPSRRAGDSNPVHPAIPNNPGASPNTKKHGIYVYRDVPQEDSDFEREQTPPTPPPRRLSRKGASFKLGCIGKQGSDENPLMRRPGQPLRVPHNNQGMAPATVPDRVVSYPPEPQVSPPSPPPAARTHLSPGGRLVNFLRSLGRRRERGGDSWEEPRLQHRHSDSSALPDLSGHLHRAPDRGPLLIPNAVQQQQQQLQQQQLQQQLQQQLVPRSLQHRRSSAETLVAKVLQDEGLNRYVDPQCLQREIAEATNMTPEEMNLAAREIIRRSRNLEPGYHPKDSGTGGGGGGGMGSEPPPRYSRSPPGQHELQERGRPASSDSLDRNPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W480</accession>
    <name>A0ABM1W480_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LOW QUALITY PROTEIN: WD repeat-containing protein 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101849428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035829473.1">
        <property type="nucleotide sequence ID" value="XM_035973580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849428"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF5">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829473.1"/>
        </source>
    </evidence>
    <sequence length="948" mass="106288" checksum="C01F054B62486245" modified="2025-10-08" version="1">MADAGAEPAAPEAEAQQEVKEATQKEEKEEDTAQVAAEPDAEAKPEAEKPAEKKAEKKPPPKGGKKGGKGKPAEAAPVEPSSSEEAPPEEDPNALPENVFPLFMTSSSQEIYHCKCDEDVTEENPFKFIPKSDILEDMKLRAAVCDFHPFKQQILDYPGEDVLIMYDADFKHGQNFIIALTEEAKEALLKTSEEEGEGEEGQEGEEEEDTTVYLYVPPEPKDWVSQGSEKEISEQTVTETRRKAKVSVKRVRQEFGAPIQFGNRNVADVKDGAMDCPSFDDKNFDLNRIELDKGVQAILDQVDQGTQTTWKYPRNANTQTYPREFSEHEQEQFVNSAECKKFVLDAAQDFHQALQQNEIMNVFHIDWIHLGDGDDLFGSKADNHLKEYQSFTDLQFSKDKIITCIQWHPTIKGVVATSVAEKLSFDERIDQAAKVIMTPSLILIWSFADPIHPQLILEAPDDIMSFAYNHSDPNIIAGGCYNGQIVLWDISAHADRLKQQRGSNRNKKRTVLPGFEDPNALKTPIVRYCAVSSIENSHKAPVTDIQWVPEHMQVSKMGVPQENSTQQCSQLMSCATDNCVLFWDTKPPKIHQLHDDKGPKQPMGVPDTFKYLDLSWKPHLRVHLSKSEPGGDHAPTKFSIQERQGDKSALASGTDYKENDPTATMQGGFHKPSSGKERTLNSVKTYIYVGTEDGEVVYVDWMPQKDQDSGKIQTPKPAYYHSLHDGPIVSMNRSPFFKDILLSVGGWTLAIWKEGVSSGPILYSAASPVRMSCGIWSPTRPGVFFIAKVDGCIDVWDLLDRTHEPTLTQSVSPTSITQIYPFQVTQKQQLIAVGDNAGTLHILEIPWSLRQPTPTETNGVANYIEREVKRRGFVVERWNFREREKRELEAEAKKKAGGMAAAMAAPTEEELEIRAKQEYQTYLDAAYLDAEHNFLRELGIIQDDDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4B8</accession>
    <name>A0ABM1W4B8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADPH oxidase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829511.1">
        <property type="nucleotide sequence ID" value="XM_035973618.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861261"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045198">
        <property type="entry name" value="CNBL1-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056">
        <property type="entry name" value="CALCINEURIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056:SF110">
        <property type="entry name" value="CALMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829511.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14758" checksum="8BB6175ABA8D09C6" modified="2025-10-08" version="1">MDKESKTLLEKIQTHFLKFSEAGGTLSKQTFLQALGDRKDSFFADRFFQYIDRNQDGVVDMRELTQGAAVLLGGSDMDKIGFLLSLYDMDGSGEISREELRRVLTACVLESNMHFSDTHLDYLTNALFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4B9</accession>
    <name>A0ABM1W4B9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101861488</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101861488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829512.1">
        <property type="nucleotide sequence ID" value="XM_035973619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861488"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035829512.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14671" checksum="BB7850153F1AD1AE" modified="2025-10-08" version="1">MMACLATASSNQLLFDDLRLSFADEDDALGVTFIENVTVTAFVVPEDEDDALGVTFIENVTVTAFVVPEDEDDALGVTFIENVTVTAFVVPEDEDDALGVTFIENVTVTAFVVPEGWRFSAEYPRVPTAAYPTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4F5</accession>
    <name>A0ABM1W4F5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Growth arrest-specific protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101849989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829548.1">
        <property type="nucleotide sequence ID" value="XM_035973655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849989"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21204">
        <property type="entry name" value="CH_GAS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF13">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035829548.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36606" checksum="5DDDD0991AF4898F" modified="2025-10-08" version="1">MPLPPHKNLSTLSGEPPSPRPPPAISNNVANGPRAEPLDLENTPETQVEENAEQVDHISQRLSELQEELFVSLKEDIAEWIVKTLGDVDISAENFIQDLDNGVILCRLSLAIEKKAKAMHQQGSLTEPLPSYKLHCNKNARSATWFARDNTTNFLGWCRAYGMIDETLFDSEDLGGSSTKTESPPPAARQSAPPPPPTPTPPASRKDSVVSTRSSTVSTLDSEVNRVSHKCKCQEYVNKLSEGVYDVFGKRVFIRLLKGRHLMVRVGGGWDTFENYLLHHDPVQVFEFHNTGGPHGPTAHSYAVNKSDFGPGSFNGYLVIRSKYKSKNFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4R0</accession>
    <name>A0ABM1W4R0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101854929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_035829653.1">
        <property type="nucleotide sequence ID" value="XM_035973760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854929"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035829653.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13948" checksum="EBCF9CFB8FC33212" modified="2025-10-08" version="1">GFGTFHSLLNSWIHFMMYMYYGLSAMGPAFQKYLWWKKYMTTMQITQFASVIIHASQLLFMECDYPIFFVYMIGFYSFIFFVMFGNFYVQSYLKPKAAPSKQLHSANGSVADHNKAKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4T6</accession>
    <name>A0ABM1W4T6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metalloendopeptidase</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_035829679.1">
        <property type="nucleotide sequence ID" value="XM_035973786.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846266"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
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            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1419"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1924"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2175"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2213"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2382"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2515"/>
            <end position="2527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2767"/>
            <end position="2778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="2823"/>
            <end position="2845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="3198"/>
            <end position="3212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="3230"/>
            <end position="3244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="3827"/>
            <end position="3839"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="4932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035829750.1"/>
        </source>
    </evidence>
    <sequence length="4983" mass="546217" checksum="C5A6C41E3C84CC61" modified="2025-10-08" version="1">[encoded data, 4983 characters]</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1986-07-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>P01364</accession>
    <name>AGN3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName>Abdominal ganglion neuropeptide R3-14</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName>Histidine-rich basic peptide</fullName>
                <shortName>HRBP</shortName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>Peptide I</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>Peptide II</fullName>
            </recommendedName>
        </component>
    </protein>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1983" name="Cell" volume="35" first="47" last="56">
            <title>Gene isolation with cDNA probes from identified Aplysia neurons: neuropeptide modulators of cardiovascular physiology.</title>
            <authorList>
                <person name="Nambu J.R."/>
                <person name="Taussig R."/>
                <person name="Mahon A.C."/>
                <person name="Scheller R.H."/>
            </authorList>
            <dbReference type="PubMed" id="6194901"/>
            <dbReference type="DOI" id="10.1016/0092-8674(83)90206-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1984" name="Science" volume="225" first="1300" last="1308">
            <title>Neuropeptides: mediators of behavior in Aplysia.</title>
            <authorList>
                <person name="Scheller R.H."/>
                <person name="Kaldany R.-R."/>
                <person name="Kreiner T."/>
                <person name="Mahon A.C."/>
                <person name="Nambu J.R."/>
                <person name="Schaefer M."/>
                <person name="Taussig R."/>
            </authorList>
            <dbReference type="PubMed" id="6474178"/>
            <dbReference type="DOI" id="10.1126/science.6474178"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1989" name="Peptides" volume="10" first="849" last="857">
            <title>Aplysia californica neurons R3-R14: primary structure of the myoactive histidine-rich basic peptide and peptide I.</title>
            <authorList>
                <person name="Nagle G.T."/>
                <person name="Knock S.L."/>
                <person name="Painter S.D."/>
                <person name="Blankenship J.E."/>
                <person name="Fritz R.R."/>
                <person name="Kurosky A."/>
            </authorList>
            <dbReference type="PubMed" id="2573895"/>
            <dbReference type="DOI" id="10.1016/0196-9781(89)90124-1"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 24-54 AND 66-108</scope>
        <scope>PYROGLUTAMATE FORMATION AT GLN-66</scope>
        <source>
            <tissue>Abdominal ganglion</tissue>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1987" name="J. Neurosci." volume="7" first="854" last="863">
            <title>Proteolytic processing of the Aplysia egg-laying hormone and R3-14 neuropeptide precursors.</title>
            <authorList>
                <person name="Newcomb R."/>
                <person name="Scheller R.H."/>
            </authorList>
            <dbReference type="PubMed" id="3549995"/>
        </citation>
        <scope>PROTEOLYTIC PROCESSING</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="J. Neurochem." volume="72" first="676" last="681">
            <title>Formation of N-pyroglutamyl peptides from N-Glu and N-Gln precursors in Aplysia neurons.</title>
            <authorList>
                <person name="Garden R.W."/>
                <person name="Moroz T.P."/>
                <person name="Gleeson J.M."/>
                <person name="Floyd P.D."/>
                <person name="Li L."/>
                <person name="Rubakhin S.S."/>
                <person name="Sweedler J.V."/>
            </authorList>
            <dbReference type="PubMed" id="9930740"/>
            <dbReference type="DOI" id="10.1046/j.1471-4159.1999.0720676.x"/>
        </citation>
        <scope>PYROGLUTAMATE FORMATION AT GLU-24 AND GLU-52</scope>
    </reference>
    <comment type="function">
        <text>HRBP is a myoactive peptide that excites Aplysia heart and enhances gut motility in vitro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text>Neurons R3-R14. A cluster of 12 giant neurons located on the right side of the abdominal ganglion.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">The partial formation of pyroglutamate from N-terminal glutamic acid in peptides isolated from single cells is detected by mass spectrometry (PubMed:9930740). There are indications this modification depends on a heat sensitive factor.</text>
    </comment>
    <dbReference type="EMBL" id="K01223">
        <property type="protein sequence ID" value="AAA27759.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="K02184">
        <property type="protein sequence ID" value="AAA27763.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M64342">
        <property type="protein sequence ID" value="AAA27760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M64343">
        <property type="protein sequence ID" value="AAA27761.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="A01635">
        <property type="entry name" value="NLGAAA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191478.1">
        <property type="nucleotide sequence ID" value="NM_001204549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P01364"/>
    <dbReference type="EnsemblMetazoa" id="NM_001204549.1">
        <property type="protein sequence ID" value="NP_001191478.1"/>
        <property type="gene ID" value="LOC100533236"/>
    </dbReference>
    <dbReference type="GeneID" id="100533236"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0527">Neuropeptide</keyword>
    <keyword id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001782" description="Peptide I" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001783" description="Peptide II">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001784" description="Histidine-rich basic peptide" evidence="1">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyrrolidone carboxylic acid (Glu); partial" evidence="2">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyrrolidone carboxylic acid (Glu); partial" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyrrolidone carboxylic acid" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="2573895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9930740"/>
        </source>
    </evidence>
    <sequence length="108" mass="12207" checksum="621C72C17BCC1373" modified="1986-07-21" version="1" precursor="true">MQVLHLCLAVSIAVALLSQAAWSEEVFDDTDVGDELTNALESVLTDFKDKREAEEPSAFMTRLRRQVAQMHVWRAVNHDRNHGTGSGRHGRFLIRNRYRYGGGHLSDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-12-01" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>P29233</accession>
    <name>SENA_APLCA</name>
    <protein>
        <recommendedName>
            <fullName>Sensorin-A</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName>Peptide B</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>Sensorin-A</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name type="primary">PSC1</name>
    </gene>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="Science" volume="252" first="856" last="859">
            <title>Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening.</title>
            <authorList>
                <person name="Brunet J.-F."/>
                <person name="Shapiro E."/>
                <person name="Foster S.A."/>
                <person name="Kandel E.R."/>
                <person name="Iino Y."/>
            </authorList>
            <dbReference type="PubMed" id="1840700"/>
            <dbReference type="DOI" id="10.1126/science.1840700"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>PROTEIN SEQUENCE OF 33-54</scope>
        <scope>AMIDATION AT PHE-54</scope>
        <source>
            <tissue>Pleural sensory cell</tissue>
        </source>
    </reference>
    <comment type="function">
        <text>May function as an inhibitory cotransmitter acting in conjunction with the fast excitatory transmitter released by sensory neurons. The peptide selectively inhibits certain postsynaptic cells probably by means of sensorin A release.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
        <text>Throughout the neuronal cells (cell body, axon and presynaptic terminals).</text>
    </comment>
    <comment type="tissue specificity">
        <text>Seems to be specific to the mechanosensory neurons of the central nervous system.</text>
    </comment>
    <dbReference type="EMBL" id="X56770">
        <property type="protein sequence ID" value="CAA40089.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="S23653">
        <property type="entry name" value="S23653"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191583.1">
        <property type="nucleotide sequence ID" value="NM_001204654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P29233"/>
    <dbReference type="SMR" id="P29233"/>
    <dbReference type="EnsemblMetazoa" id="NM_001204654.1">
        <property type="protein sequence ID" value="NP_001191583.1"/>
        <property type="gene ID" value="GeneID_100533364"/>
    </dbReference>
    <dbReference type="GeneID" id="100533364"/>
    <dbReference type="CTD" id="100533364"/>
    <dbReference type="OrthoDB" id="6133866at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0027">Amidation</keyword>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001927" description="Peptide B">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001928" description="Sensorin-A">
        <location>
            <begin position="46"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000001929">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phenylalanine amide" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="1840700"/>
        </source>
    </evidence>
    <sequence length="113" mass="12711" checksum="74350F5154B49E1A" modified="1992-12-01" version="1" precursor="true">MPSRAATSPLNVQMMVVLCIVCLALQAVAANATRSKNNVPRRFPRARYRVGYMFGKRSSSETYSTNLINLLSRQLVSQEELRAILEKQPILLDEVVKILDRNDDGYITVADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YXV6</accession>
    <name>Q7YXV6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate [NMDA] receptor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="34" type="primary">LOC100533321</name>
    </gene>
    <organism evidence="32">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="32 34" key="1">
        <citation type="journal article" date="2006" name="Biol. Bull." volume="210" first="255" last="270">
            <title>Molecular characterization of NMDA-like receptors in Aplysia and Lymnaea: relevance to memory mechanisms.</title>
            <authorList>
                <person name="Ha T.J."/>
                <person name="Kohn A.B."/>
                <person name="Bobkova Y.V."/>
                <person name="Moroz L.L."/>
            </authorList>
            <dbReference type="PubMed" id="16801499"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="32 34" key="2">
        <citation type="journal article" date="2006" name="Cell" volume="127" first="1453" last="1467">
            <title>Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Edwards J.R."/>
                <person name="Puthanveettil S.V."/>
                <person name="Kohn A.B."/>
                <person name="Ha T."/>
                <person name="Heyland A."/>
                <person name="Knudsen B."/>
                <person name="Sahni A."/>
                <person name="Yu F."/>
                <person name="Liu L."/>
                <person name="Jezzini S."/>
                <person name="Lovell P."/>
                <person name="Iannucculli W."/>
                <person name="Chen M."/>
                <person name="Nguyen T."/>
                <person name="Sheng H."/>
                <person name="Shaw R."/>
                <person name="Kalachikov S."/>
                <person name="Panchin Y.V."/>
                <person name="Farmerie W."/>
                <person name="Russo J.J."/>
                <person name="Ju J."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="17190607"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.09.052"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Song W.-J."/>
                <person name="Kurnit D.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="34" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a heteromeric NMDA channel with Nmdar2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AY163562">
        <property type="protein sequence ID" value="AAO62106.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191411.1">
        <property type="nucleotide sequence ID" value="NM_001204482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7YXV6"/>
    <dbReference type="SMR" id="Q7YXV6"/>
    <dbReference type="TCDB" id="1.A.10.1.22">
        <property type="family name" value="the glutamate-gated ion channel (gic) family of neurotransmitter receptors"/>
    </dbReference>
    <dbReference type="GeneID" id="100533321"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017146">
        <property type="term" value="C:NMDA selective glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035235">
        <property type="term" value="P:ionotropic glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06379">
        <property type="entry name" value="PBP1_iGluR_NMDA_NR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13719">
        <property type="entry name" value="PBP2_iGluR_NMDA_Nr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000010">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018882">
        <property type="entry name" value="CaM-bd_C0_NMDA_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049872">
        <property type="entry name" value="NMDA1-like_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049873">
        <property type="entry name" value="NMDA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10562">
        <property type="entry name" value="CaM_bdg_C0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="19" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="16 32 34" id="KW-0675">Receptor</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 29 34" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="29 34">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004295005" description="Glutamate [NMDA] receptor subunit 1" evidence="29 34">
        <location>
            <begin position="25"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="30">
        <location>
            <begin position="397"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="31">
        <location>
            <begin position="429"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="862"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="924"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="872"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="949"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="720"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="25">
        <location>
            <position position="651"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="25">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="732"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00024675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="AAO62106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="RefSeq" id="NP_001191411.1"/>
        </source>
    </evidence>
    <sequence length="964" mass="107494" checksum="55152BFCC6D96498" modified="2003-10-01" version="1">MHKAGIKMLLLAATYLACCVYAQASEQVITVGASLSSEKMEFEFKQAVNALNRRHLKSRILFNSTTILMDSNPIRSALDICDKLLAQHVYTVVASHPNSTDHSPISVSYTCGYYNIPVVGISARDSAFSDVNVHKMFLRTVPPFAHQADVWLELLVNLTWHKVIFVYSADEEGRSVLSRFQTLAEEHNIRIEPSVKYAPGEKNYTSVLAPILKHTSRVILLSASTEDAEVIYRDADVLGMTGEGWAWIVSEQAFDAYNIPVGFLGVHLVNGTNEVNHIKDAVQVIGHAFWSLLDTENISNPPTECKDIDSWTDGEKVYNELIKTQLNGETGQVSFNSEGDRLNPMYDIMNINGNRRSMSVGLYGHQEKVLGLRMMGRNITWPGNTQEKPKGEKISRNLTIVTLKEKPFVEVLPMPKDGVCRPVAPAVHAFLCKNASQDNCCMGYCMDMLARIAEKVKFNFTIHLSKDGLFGSFEKHNGSDKKYWNGMMGELMTKEADLIVAPLTINPERANDIDFTKPFKYQGLNILVRKTQKDSSLASFLQSFQDTLWILVGLSVHVVALVLYLLDRFSPFGRFKLAKSDDTEEDALNLSSAMWFSWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLDRPEALISGIDDPRLRNPNKKFKYATVKGSATEMYFKRQVELSTMYRNMDKQKKYYTAEDAIEDIRIGELQAFIWDSPRLEYEAASDCDLTTAGDLFGRSGLGIGLPKNSPWTHEVSMAVLDMHESGFMEQLDNRWILVDSKSSCPESNSAPATLGLTNMAGVFMMVAGGIVAGVLLIFIEIAYKRHRGLKEKELELARNAADRWRGNIEKRRTLRQTLQKQREEQMRTNSISKQPASNTSLPMAPNANTAVASAPSLDSNNTNTITPSYRRLSLLEATTKSDCLPPPPPSDYRPPGYVPARSGRTVTWHNPSHNPDNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAN6</accession>
    <name>A0ABM0JAN6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase</fullName>
            <ecNumber evidence="3">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101853043</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005089304.1">
        <property type="nucleotide sequence ID" value="XM_005089247.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089305.1">
        <property type="nucleotide sequence ID" value="XM_005089248.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853043"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021062" description="Amine oxidase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="63"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="226"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089305.1"/>
        </source>
    </evidence>
    <sequence length="556" mass="62370" checksum="ADBF301A15B755A2" modified="2025-10-08" version="1">MRRKIFVLAVLLVAEFCAADRGRKKEKTSEKSSVKTDSEKEDDGIKKAYPLLHKEVVVVGAGIAGLAAARRISKDRSNFTVTVYEAQKNRYGGRVWTDKLTNMKAKGVEVDLGSSAFNVISKNNPLLELAEDFELKTSSIEGLQFIIPWEGKVYSGSDIQDITKEAGQILNQALNESKSWKFEPSVREAVDKVLHDDFSSESTGSHLVKCLPSYVIKDYSTRHYRPELLDMGYEKVLLDGTGELLDRLVSGSSEEPPLHLQLNKAVRQIKFDNSKGKVIIRFRDGSQRQTDVVVVAVPLSIIASQDIMFEPDLPKNYQVAVSEMGVLTSNKLILEFESAFWPSDFGVFLRAVQEDQDRGYMQSWINIHRLVGLPVLTTFVMGDSAIGFEKMTDDDIKQSALDVLIEMFGKDTVSKGGDVVRLQRSQWVTEEFSKGSHTYSKVGTTPELWETLSEPLCPGVYFVGEHTSLGEHGTLHGAYNSGIRAGDQILSRYCEKKMEEEERRREEARRKEAERKKKENGGGANASEERATKEVSLEDDDDVVTEEESDERKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCQ3</accession>
    <name>A0ABM0JCQ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vam6/Vps39-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090680.1">
        <property type="nucleotide sequence ID" value="XM_005090623.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859617"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="15"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="562"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005090680.1"/>
        </source>
    </evidence>
    <sequence length="878" mass="100920" checksum="8FEBE10D7E741998" modified="2025-10-08" version="1">MHDAYEAAPVFEKLPLHIESIACFESTLLVGTRQGVLLQYKVTKNGNNKLDVQLERSNKSFAKKPITQLAAVPELFILISLSDNVISVHDLTSLTLITCVSKTKGATLFAIDVKKRQTANGDFQPSLRIGVASKRKIQLFKWERKDFYEILNDLSLYDFPHALSWCRDSLCVGFKRDYYIINSTTGNLKELFPVGANQPDPIVTRLHDHRLALGRDHMSILINADGDPTQKEPILWSEIPTAMEHCPPYLIAILPKYVEVRTIDPKLKIQDLTLPKARLICQGDGSIYVASPNNVWRLAPVPYSIQIRQLLQGKEFELALKLAELSKEPESEKEKRIRNIKNLYAFELFCQRRFEESLTLFAKLGTDPSHVIGLYPNLLPQDFRNKLEYPAKVPDLTDTECEKGYLGLIEYLTQKRNELLKDIDKEMSTTAIVEGNKTINSRKQLSQIIDTTLLKCYLQTNDALVAPLLRLKDNNCHVEESERVLKRKEKFSELIILYERKGLHQKALNVLMKQAARPDSPLKGHERTVQYLQHLGSEHLHLIFEYAEWVLKQYPEDGLKIFTEDLPEIETLPRDKVLDKLESINSDLASQYLEHIILDCHDQKEEFHNRLVDLYRDRVQKLRDEYVHSLPEGHPPRKEGEEPNELGVMRKKLISFLQNSQYYIPERLLTRFPTDGFFEERAILLGRLGRHEQALNIYIHVLKDTKLAEDYCAKNYARDKEGNKDVYYLLLKMFLAPPESHQAVGGAVGGATGTVLGRNKVDVALKLLEDHARQIDTAKALELLPSDTKLRDILTFLENVMESQAVRRRSNQILKSMLYAENLQVTDQLIRRQSVKVNVTDEDICRSCRKRIGQSVFCRYPNGHLVHYSCYTKDAQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD15</accession>
    <name>A0ABM0JD15_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Failed axon connections homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090892.3">
        <property type="nucleotide sequence ID" value="XM_005090835.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864356"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="137"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090892.3"/>
        </source>
    </evidence>
    <sequence length="302" mass="34642" checksum="89A4F8BCE2859B9D" modified="2025-10-08" version="1">MFGVKDFELIMSDIRESPWTWLVAGGATLTSLYLLHSKVKARSSKKASKSKTVPPGTVILHQFQRGPFAPSFSPFPIKLETYLRLAKIPYVTETNENMSKKGKMPWMEYNGEEVADSHICITYLNQKLGIDLNKNLDPVQRATARAIQSLCEDHLYWALVCLRWLWDPERKLVKMFVKSPIVLWLVVRNLGNQAWGQGMSRHSRPEVKSFVLEDLQALTDFLGDKKFMMGDEITEVDCCVFGFLCQLIYHQKDEFFDGLVEARFPSLVQYKDRVKTLVWPDWDDISAGKETPLSGTLLEGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDS2</accession>
    <name>A0ABM0JDS2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuropeptides capa receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101847632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005091362.2">
        <property type="nucleotide sequence ID" value="XM_005091305.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847632"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005091362.2"/>
        </source>
    </evidence>
    <sequence length="353" mass="39290" checksum="C42E5ACE55FA0330" modified="2025-10-08" version="1">MNLTTSMFLSSTNISLVRLTATDTSHEQSRGLVSAEVRHSFIVTCLVVIGQIVCLFGIGANIASIIIFKKHGFDDTVNISLFALAISDLGALVAQQWFNICVNPWFENSDIPFSSMEIQNLTAGYPRRYFTKTAGWITAFVTFERCLCIAKPLKVKSLITRRVAIAVTIGIYIIIIPSILPGYLTSYFDWKFYPTKNRTLLGLMFTADGKEVMGSSLFVTDALVPLLSFGCVVVCTLIIAVKLKEKDKWREKVSSEANTPGQMSRKNRKVVVMICVISGIFIFCTSPISALLVARSVEPELTVIGRYANLTWLLASLGMLTETVNSSINAVVYYNMSTKYRDTFRDLLRCRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE76</accession>
    <name>A0ABM0JE76_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Toll-like receptor 4 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101861183</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091677.1">
        <property type="nucleotide sequence ID" value="XM_005091620.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861183"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="908"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005091677.1"/>
        </source>
    </evidence>
    <sequence length="1052" mass="115620" checksum="32B2CC88F74648EB" modified="2025-10-08" version="1">MTNVFTDSRTRILAAKMTGDLQHPSITYQHLDKTGSRLTSGTMYRLLLFCAAWTACDVTLTAAAASPNSQTPSPSSSQCVGADCRGQVLLSSPSSSSLSLRSSLSSSSSLPSSTSSLSFSSSSSLSFSPSSSSSSSLSSSSSLSLSPSSSSSSSFSSSSSLSLPPSSSSAPSPCIVFTDPEGDEVADCRGQGLTRVPTTDLPHTTVKLHLDNNLIASLPDCTFSSVPNLKVLTISKNRLERVSPCAFCGIESLERLNLGGNRLNLSAPMWGKRPFRNLGQLRDLTLANNNNGDLEGDYHKNLLGGLESLQFLSLDTFYGCLRFGNIFGNMTSLDRLSLSGGLSVIKNNTFRSLQTLGLTSLSLTSADNLHTTELDAFNHLSDLHSFSIQNTNQGLKKTLRSLYPFRNRSLKTLYLRAIGTSQFERGAVKCSDGIVDSYKVEFLSQICVESFSLIRSGVYAVQGDTITGPVWRKCLRSLDLSSNPLIGDRITLLQFVRFKALKVLDLSNRKQTSSYSNPRDEYLEARENLPSSSSIHRMRSGSVRSRSIGGIKTRHERSVHNGVYDTGDVISFDSDRHGDVQTALPFKLAVGGSLSNRISGHGYSAISIRFPKSLEIVNIQSFGSSMGSLSSDVNVVGGGNIRELYLGDNSYTDFTGAVRGFTRLEICDISYNNCSNMSPSFFDTAPTISHLKIRGAMLDSEFMSTQSERLFRPLRNLTVLDLSDNNLSLLSENVFRNNSILRALVLEKNRFKSLPFVVSSLPNLEHINLRSNSISQLNEKEMQAFDEQLMRSPEFSVDLTGNIMVCGCSSIRFLYWLQNTKINLDKPVNYSCITEDGTLKTVGDISNLKSLRRQCQGKYFLLISIILFCFLSLGFVITISYAKLQTRIKSFLYRTFISGFNMHTPSDYRIGVFIGYADADTRLACFTLRDFIQSELSLSTYVRDINTLPSSDIAESIVDAVNSSWRIVLIVTHDFLNNDLWSYFTMKTAVYMVSPSNPGLIVVLTEESVRHRLPVSLLRALEEESIVCMPPTHHLDQGHRRTLARLLLPSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEJ0</accession>
    <name>A0ABM0JEJ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter AVT3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005091906.3">
        <property type="nucleotide sequence ID" value="XM_005091849.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852002"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF703">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005091906.3"/>
        </source>
    </evidence>
    <sequence length="180" mass="19688" checksum="41805ABA7FF37681" modified="2025-10-08" version="1">MYFPVAVTGALVYGKTVQANLLLSISPGPLLYMVQILITCHLVCSFVICLNPVAQQLEELLKLKKTFSWHRIVSRSLMVAFVLFVAETIPKFGTLLSLIGGSTITMMAFVCPPLFYLKLCSMKGHWPQIVVPLHQKVLLLEILIVGSVVGLMSTFSSVQSMASPDSFTVPCYINMTAACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG00</accession>
    <name>A0ABM0JG00_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endonuclease G, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092828.1">
        <property type="nucleotide sequence ID" value="XM_005092771.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846197"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="3">
        <location>
            <begin position="79"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092828.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36456" checksum="A5731EC67023E2AE" modified="2025-10-08" version="1">MFRNFSYAACALAVGIKNHADGPKDLTLPAANMLSLEKCLPSVSAHHHHHHGCEPMYVGDRIKKTVGFPQLTACCKPLRYKDFIISYDTKNRIPNWVYEHLQYNKFFKDDPCDKRVNVCPYNDDAAALGIEKPKFHPDCRIHGYHRADVKDYCDTDYELGLMADPANYPFDSEACAETQVMTNVVPIVPGFSCGPWFDLQCYIREKLVRENKSVYVCSGPLFLPCDNEGKACMKYDVLGEGEVSVPSHFFKVIIIESHDGNLELESYMMPNVTPEEGAEVNLDDYLTPLCQIEHASGLIFFPEKKVCFTSNNKRRGARLHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGQ7</accession>
    <name>A0ABM0JGQ7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101855238</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005093305.1">
        <property type="nucleotide sequence ID" value="XM_005093248.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855238"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1127"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="10">
        <location>
            <begin position="493"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="649"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1161"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1165"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093305.1"/>
        </source>
    </evidence>
    <sequence length="1199" mass="135912" checksum="D8B9B68623863392" modified="2025-10-08" version="1">MTGRRELSPLLPRRPEEYRPSSSTLVSPFCSSLLSRSSRSALSSSLSSPTPWRAVMLLSLVSLSLFLVPASAVEDLRLNAGNVKRRDVISNININNVNNVNNDGGVAQVRRRNNGVPQIPKRPAEDVVKPAKKVLAPAIQRAQENQAELNRQLEEHERQVAQQQAEMAGREKRRQERQRQLDIQRADNLRQELEQKQRDKERQELSRQRERQREKEREQQWLEDMKKKAEDQMKLQQQQELAVKELKARKELEGAGLPGGNKLRSGEVPALKNAGPMLNEEEKSPQQDVRKQFDAEGLLSKKDLGRDSVRNVAGAGLETRDRQKNAGVDLPAGNNGENVANQAQAEPPNPVQHDNPAANQDALKVVARVPEPGEKLPGSDNEIPRSERDAGDQINNNAELPNLPQQVPNVLSNNDNSQVNNNDNDNMGGGGNNNQNQQYQNMNDDSNRRDRDQPQIGGLHLSWDWEDFSIMFSNYGNAEMKVRRAPHPTTGEPWPMPQYYSKKDKKVYKVSKDLRFVPTGVKCDILDEAIVRHLQRVLRGAVEDMYDNLQHAEGTFVDDPSLKYDSEEYVKAPTISRVEIKVRKACEKYPTLDSDESYDLVVKKKKTYIWANEVWGAMRGLETLGQLVWKGTDGLLYIKETVISDYPRFPHRGLHIDTSRHFLFKEIILDIIESMEMNKLNVFHWHIVDDQSFPYESKVYPELSRKGAFHPTYVYSLEDIAEIIEYARVRGVRVMPEFDTPGHTYAWGLSRPELLTQCYSGSTPVKGYLGPIDPSKNSTYRFLQTLFQEIMGVFKDQYLHLGGDEVPLGCWQSNPEVMAFATELSKKSSGRSQQQAGSSFYNSNFGWNNVWSEDVKMVYEYYVNRLIKILNDLGHKRKKGVRYIMWQEVMNNNLQLPNDTIIQVWMGDMADVMRATSMGYQVLYSTCWYLDHVEYGTKWPKYYNCDPVDQSYGYHIDEKKVLGGEIAFWSEYFSNENLIPLMWPRASAAAERLWSSKDVKNLDKAAERLSEHRCRMIKRGVNAGEISGPGYCLHPPPRRRVLNDTLGCKGGNCSRTHNFVQIEDIELHVSQRGGSLADCGHVFSRANNNVMVMLALALVVVLALLALSRSSSRLHRLRLCRNRSILIVFVIVLLVYFLCYTTIWIRAFEFSGSFHKTLQEDSPGGESGGKGGGGVGDMSHDTGAGGGGGGVKYSKAHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGY6</accession>
    <name>A0ABM0JGY6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Platelet-activating factor receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101850403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005093456.1">
        <property type="nucleotide sequence ID" value="XM_005093399.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850403"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005093456.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38916" checksum="BFFFDFAD3297B631" modified="2025-10-08" version="1">MNNSSNTTSLLQEAQASGLLNERVCSILLFLNWSVLCAIIAVFGIVANIINIIVFIKMGVRGTAVNLSLLCLSVADLGSLLLLAWISLASNPLFTSLDLPFIPLNVAYVTGGWPRLCFVRTSGGITAFVTLERCLCIKTPLRVHRIFTPKRTAICLAAIFFLMLLSALPAFAYIDLAPIFDPEKNKTLIGTVYNDKENTIKPVVTVAGFVVTTGSFLCVSVFSAVLIHALIQRRQKWECSKNVYTLQTGAARSSRSMPTQNKDMQVAKMILLIAAVFITCFVPHGAIFLIMELVEEFNTGKAYHNLFTVCISFIHIFEGVSFAINILLYIKLSSKFRHTIRALFLPLKQTSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHQ7</accession>
    <name>A0ABM0JHQ7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101855409</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005093919.1">
        <property type="nucleotide sequence ID" value="XM_005093862.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855409"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005093919.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12679" checksum="2BC5D3DCB78C6E51" modified="2025-10-08" version="1">MPILSISTNLKRDQIPGDFLPEATKFVSAQLGKPENFILVQVNPDQLMSFQGSSEPCANISLGCIGVVSAEKNRELAPIISEFIEQKLGIKKDRFFICVTDVGRSWCIWNGSTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI59</accession>
    <name>A0ABM0JI59_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rabenosyn-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094166.1">
        <property type="nucleotide sequence ID" value="XM_005094109.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850072"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="176"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005094166.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="61648" checksum="7312A997EE079F67" modified="2025-10-08" version="1">MNGFFKQGSGNLKRLEAGGGEQAVTMSADIIEGFLCPICMKDLGTVSQLQGHFEEEHSSEDKAVFQSLKGFFDKAKKRILGDKLETELTPGGEPAKREELGGLSGYDPSWWEEQELGAIRSHTDTFKSVRDARVDHFVVETNKLLIRLDKLLSPEAPADPKKRKAFERAVVQWIPDNEVSACLSCGRSFGLLTRRHHCRLCGRIMCDRCSEFMASSYAHKLVNPGHNFSGEGFLKRSSSNTSINSLVSQDGESHMRVCKTCRKLLERRDVMTEQRNTKPAIVQIYDKMKMCISDAEQILPDYLPMVDSLSQGETVHNFRQALIMRTKLVKLYEAVDQLSKKIMLLPVPSDTNSRQLHLQKSIRIYASNFMQENLMGLQALPTEEEYNKLREARAAEIQRKIAAERQAAMDAQERERRERLARDSQSGNALSAEEGPQFGHRRVGSSGGSEQSKRKLIANKILNSAGSKSHTRSDSEGGVGTDKGWKPVEESTRAQKVSDPMLQQMEIIKGYIKQARQAQRMDEVVMLEQNLKELTAEYTRQKQQESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI76</accession>
    <name>A0ABM0JI76_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Testis-specific serine/threonine-protein kinase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094209.2">
        <property type="nucleotide sequence ID" value="XM_005094152.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860487"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094209.2"/>
        </source>
    </evidence>
    <sequence length="352" mass="40367" checksum="0DCCF666C2D14C48" modified="2025-10-08" version="1">MMRDVSSLRQTHLRFFRKSAESVLTDYFSIELQKEVGSGYAGTVYRGLKTRGSNREEVVAVKHIRKSKVKGHLIDNEVRLLRMAQGNHVVHYRSAFECLDSYLLVTELCGQGDLHSLLHYLDSSEVMARDFMRGVAEGLEGLHEKLIAHCDIKMKNILISDKNVPKIADFGFAMLMNHSEEKTSICHGTKDYWAPEMFLPSPNFNPFKADVYALGVTFLGVCEKRPIKRKDDDINRIVRHIEDPRKKALFEGLLDPSPKSRSELDVMKRNRWMTEGGRTERISVDRLKPAQVDPTHPVHLQQPARRGRPPVLREPKPTVRSTDGREQDTEAVHHRQLTTPAGRRVRPPTRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK31</accession>
    <name>A0ABM0JK31_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dye-decolorizing peroxidase YfeX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101849758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005095556.1">
        <property type="nucleotide sequence ID" value="XM_005095499.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849758"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF0">
        <property type="entry name" value="DYP-TYPE PEROXIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="6">
        <location>
            <begin position="264"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005095556.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47034" checksum="11E5B8513365A280" modified="2025-10-08" version="1">MSVFSKARFLAPLLAGTKRQALSSGLKVNSSKTFGVGSGVCCMGIVCAGALYLKNQNEESSKSSFWPQGKLNSILKFAVPTVYGKGTREEFLTAPATPPIGKTVKNTSLCHDPCAAKKKPRKSCQVSQCNITSEAKCYSLFLWISINPSANPCCVARVAADIESAIDSVTEPCEDPSQEVVAGVGFGPNFYSQVMGKTCKNFYYSARKGANGELPSSSGDVFLHAKCNNKGKLFDLCKNYICSFPEGSICEFEDVYGFDYQNGRDLSGFLDNRTNRCDEEGLKDVAIECETGGSYALAQKWVHDFCIIRPENKPALEKYIGRDMDCGKELKCKGPSSHVARMTGTTEQNATPQYEIVRQSQNYGSLANDAGMFFLAFASDPAAFEFMLDQMVGAGCDNCCDDVMKISKNVKGTYWYFPSLRELCALVNSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKW9</accession>
    <name>A0ABM0JKW9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 25 member 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101864451</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096117.1">
        <property type="nucleotide sequence ID" value="XM_005096060.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864451"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="210"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005096117.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34410" checksum="48832B1BB70C5075" modified="2025-10-08" version="1">MSNGHGAMEFVLGGLATCGAGFFTNPLEVVKTRMQLQGELKALGQYAVHYRNALHAFITIARSDGLLALQSGLVPAIYYQFFMNGSRLGTFQLQVNWGLTKDKNGNHSFLRSVPAGAFAGCVGAVIGSPFYLIKTQLQAQANHEIAVGHQHPHESMSHGLKTIYKSQGFLGLWRGVSGAVVRVTVGSASQLSTFSAAKNFIEGTKVFAPNSWVTTFAASMVGGLAVTCFMTPFDVISTRLYNQPVCGAGKGTMYTGVADCFLKILRSEGVWGFYKGWGPSYLRLGPHTTISLVLWDQIRKLYVRWQTPVPGDVAMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKZ5</accession>
    <name>A0ABM0JKZ5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101854492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096160.1">
        <property type="nucleotide sequence ID" value="XM_005096103.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854492"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005096160.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32213" checksum="618B62EECC303A40" modified="2025-10-08" version="1">MPRYAQLVIGPAGSGKSTYCSRLVKHCEDLKRSVQVVNLDPAAEYFDYPVMADLRDLIQIDDAMEDTSLNFGPNGGLIFCMEYLAQNFDWLQEQLDEQEDDYILFDCPGQIELYTHIPVMRQLVERLQAWDFRVCVVFLLDAQFLVDAAKFVSGSLTALSTMVNLEVPHVNVITKMDLLSKSARKHIDRYLEPELSTLLMDEFEETNVGPKFKSLNKAMAQLLDDFSLVHFLPLDYNDEGNITDLLVHIDSTIQYGEDLEPREMRDPVDAEGQNEDVDSGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMY9</accession>
    <name>A0ABM0JMY9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDB1- and CUL4-associated factor 6 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097466.1">
        <property type="nucleotide sequence ID" value="XM_005097409.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860015"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF39">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="431"/>
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            <begin position="445"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="722"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="840"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="917"/>
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            <begin position="1120"/>
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            <begin position="278"/>
            <end position="298"/>
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        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
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            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="392"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="482"/>
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        </location>
    </feature>
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        <location>
            <begin position="534"/>
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        <location>
            <begin position="753"/>
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            <begin position="854"/>
            <end position="870"/>
        </location>
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            <begin position="935"/>
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    </feature>
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            <begin position="1134"/>
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    </feature>
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            <begin position="1161"/>
            <end position="1176"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1205"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1236"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1281"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005097466.1"/>
        </source>
    </evidence>
    <sequence length="1491" mass="159643" checksum="2FC7962AC17EBCAE" modified="2025-10-08" version="1">MFGTIKNREHRSCPPRRLYDVTTGSLHFLQRLKLEKKLCVHDGCVNTIAWNDKGTLILSGSDDQHLAITDPFSAKTLVKFRSGHRSNIFSAKFLPGSLDREVVSCSGSGEIFFTDVDREDTYQANRFDCHFGTTYKLLVVPNEASTFLSCGDDGTVRFFDLRTKTSCSKFNCEDDVVIHLRTAITAIAADPIIPFQLAVAASDGIVRLYDRRMLKTTDAGGANESLICTMACPTTRREKRHYRITSLNYRPGSHDLLVNYSSENIYLFNTYQTGCQQTYSTQQPGPSGVTSKPVSQSRDLGGCASPGTSRASAEGAVGAVGGSPSDNGSDSENLFKPIKRLRLRGDWSDTGPDARPESEEPALTNTIMQRMSDLLTRMLNSRSDRGPREGGEGEEGEGEEETEESGQPGDSQTEARSENETEGPETSASADAAAVLRSVIFSSPSAAAARQSLGQERGAVARYTVPSEGLGLPDISSRDLDSGNSSELTAPSGTEATSYHTAVTSHVEVFKAPYRGGLSNTQSDRQGETVTGEHGVEEKDGEKEDGKKVVVSVAGMTGRDDSDAILASARLTVEQPDEFVCAENNSESGQVGQMVTPAQDVVSSVDEVMDKGRVDSGARGGSGSLCPADGKKVRNTDSGGKSTQGQDMAGSVVSETVADSIVSETVSCGQSLTDCGVNLSAFGGSHATSREDVHCVMRLTGNKSDISGAGHSGSSVHVSVSETLVENDGNSFDVDTDERRSRSSNIAPFDIGSGNSDSISEKQMSSGLCGMKPSSGRPAGCCDSGELTPARRDGDEQPAHAQRLVADDSAGGTSALAGVESARVSKNFTATADGEVVTTVKLPPVENSFVPGRGQERLADRRLEETRGDKPGTSSHKSAPTPSDSPSPSQSSNKAVDSLSGLSLSWSDSTVAVAEPMHSTYEGNAHPRSLDDVSNLPSRLSSGMALSTVHAEVSPSPPAPQQVSERQDSRPFDDVDDNISSLTVNVRISESSVEQSSSLSTDIPSQHSCVVASPDTGQAAVCDRSEITHFGATQWTDTESTHAKTTACSGSENAQTRTVNVAQSVPSSESQVCKVCGVELVPGVRSLSAPSLCAECAKLKQGVKEGLEKTERESLWGVGHGAVGAGQRNSLGRISEEDSDRSLEQEVLGGRKKDGKGKGVGKSSAKAAHQAGKTAAEFSPYNSGRMRFSAKEQGMFGSGCTTSSRQEEISSKDTDDSTRGPSRSLFSPSPPTDSKPMIDAHPDRKDLQDPTPGFRASTSGSDRHRRVGHSLPPTGDFQLDGNDEEDDDDNDGDDPQPELSNNKRKMSSDSDRMSRAAQKIQEVYRKKREAREMAKVMEVPQAKVLMKYSGHRNCRTMIKEANFYGDHFVMSGSDCGRILAWERETGRMVMYMDADRHVVNCIQPNQFYPVLASSGIDYDVKIWMPMEEDAQFDSDKAEMIVRRNELMLEETRDTVTVPAAFMLRVLASLSQIRTGRNSGRGQPSQDSASQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN49</accession>
    <name>A0ABM0JN49_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 271</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005097580.1">
        <property type="nucleotide sequence ID" value="XM_005097523.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864688"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="609"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="833"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
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            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005097580.1"/>
        </source>
    </evidence>
    <sequence length="974" mass="110146" checksum="DC11698E20639EE6" modified="2025-10-08" version="1">MDSSFTDMDESACIETWQSFYGTFQTSKAYISHTPDGSEVSLINAGTSLLYDTGGSYASELFQKCGLFGGDVIKLNYLLWKLEEVCLPKIAVMYERFRRAESSMKAEPIEASDTTTRAHTLINFDGKEVYKGPAALMSGEAGTVLPHNLAKTDENRQHATTSSSVVCDTPEGKGHGVGESVGYVDKTEENSLTGSAGGSKREGGGITHREKLVPDRRPKGGGKRNVQKKVTRVLQERQPESEIVKVKSEVGKTDQRDGEGLGIRRSSRQVRVSSKFSDAKQVTKWIKNVLKPEVLSSATTGNGDSNTPAQESTAPPMMCSVCRETFQCSDEFLVHWGNHLDKADSGEKKPFMCDMCGEEFETFPDVVSHYTALHPGGDKSYACGICGNHFHLKKDLEEHVETSGHELNGQHNDHSRRESGPGDSDEKVLTNRTQKAKGPFVCSLCGKHLSTERNLELHSRLHNNERDFKCGHCQKAFISEQSLKAHLDIHTGEKKFSCEICGKKFRQKSGLKYHMKLHDPETMPFKCDLCPKSFIEKRCLDSHMAKHNGQKSFFCDVCGKGFYGEKGLSNHMKLHDESSRFRCEVCEKSFVSNKHLELHQTVHTGERPHICDVCGKSFRLQGGLVAHLKIHNPEEQMRCTLCSKTFIEKRSLENHMLVHQGIKPYKCSVCQKGFLREQTLASHMNLHTRENCHKCEVCDKLFITKWGLIKHASIHTGEKPFVCNTCGKGFRIKKGLTEHLKLHNKDLQFKCSLCPKSFVEKRGLEYHMRAHRGEKNHVCEVCGERFVNKNSLKVHYRRHTGEKPYKCSFCPKTFSQQGTLTAHERYHKGEKPFVCDVCGDGFYTRSHMTIHRRKHTNERPYKCDHCEYASTTKSMLKTHMLRHTTSKPYKCTFCSAAFKRLHHLETHLLKHTDEEQLIQCSFCEATFASASRLERHMRTHEIVVVTAAPGQVIFEPKLEDEDVPHEVAYDIVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNB6</accession>
    <name>A0ABM0JNB6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Serine-rich adhesin for platelets</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101856803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097714.1">
        <property type="nucleotide sequence ID" value="XM_005097657.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005097715.1">
        <property type="nucleotide sequence ID" value="XM_005097658.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937581.1">
        <property type="nucleotide sequence ID" value="XM_013082127.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856803"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1389"/>
            <end position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005097714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012937581.1"/>
        </source>
    </evidence>
    <sequence length="1405" mass="147196" checksum="4C5CCE718459CB14" modified="2025-10-08" version="1">MADVASSMSASSPPGGSSGLSLLSDSPDLAIISPGVKEAMDRIFPKSASQLLQQRPSQDGGDGPISSSDVGMGSAESSLFCGLEPSAFGGLTKKGDGIRADPGSVPSESSPAIPQTEPQVTPKTADNGSIQSSEKRPISKLRITKADLEIISSLHSDFDELSNKSYSENSQGKSKENSTNDCYSNDSDSEDMCRPFASVAKAKKKDKKHKKKKRRKEDLNRSDVLNSVITIDSEEEFHKGKRKTRNDINLSEKNLSQRVVIRAFEEDSITSVKEATKRNSTSSRKLSQSLDASPVVQVSSEENSSSMQDLSVSQQSSQNSFPSNWSVSATTSVKDIALASDDVSNISFSSSKENVHSQVRSGIKLPKVRKPFYDVKSDKKRIRNTFPPCCVVLTHLGNISQTCSVEQWSLMDSPTPLSVRLKSLRTLCARGGIKCKHRKKQLKGAAYGNFHDVNNYTGQSEEEFETARGGRSLRKRNQNISYAEPSEFADDLMESGSSRRKSKIKDRSTDRENDSQSESDSSQKKGDSSQNKSESSQKKRKLDPSNMNGEDEKKEQNNKEQKKLVAGKAQHVERKGADGKTQVYVYPSSKLLEKQSKEKSKGRKSDAGTEKSKTLASSHRSLAPVPRSSNVSVLVNSTSQSLQPIQSSVLSPMPLGLSGGLMPLASRPIAPSMFPSSVASTPVVASSTFPMPISTAAAGKPQYCMMKMDGKDVLVQLLPSGMIGPAYSGMQSMVLPGGKRFLLTTPPPSMVAAAGQPRVIGQTILRRAPAPVGVTPIGQPHVVSVASSSGTRFVATSAPMNAAAALADSSGVRSSIPILSSPQLGRITGISVGQAFSLASGSLMATTSFSTAPIPVISSSSSAVVTAASLRDVTSVTSALSSVRPSSAVTSMAAPSSTTVVHSARTPAPSTTRAPVTSSQAVPTSMRSLRVFVPGCSATGTPGHFTTLASVGSGSPLTRLSASSDLLPQRKRSAEKELTAEQKAAKRRKLEKKYPLPPGVVIKTENPDTPSTPTSLKNSSNTNMRSLLRQNVLRQNIVFSTARSGAGGNIQSIRIITPAFASALTNRPVRPGSNIMYRAANVGGRQTVLVPITVGSSGTTSTTGSVMLGLSSSVLSSSTFSSTSTSSTAASQAAITASSIIATSSPSISTLVSNTAITTASSTTATTCTTVVSSAMGAVSTSPPILRRNRGSNSSPLPPVLVPEAAVSSENGRSDSTITSTSSSSCVNDATSEDPAHSDGPSDHVTTPSSGLASTSSRPDTDVSVSCVTGTAAEAPSRATGSTTSNCLTSLPENSVEAGSPSVSLRSGSPAASMGILQSSQAALASLRLLVKAQEANGLKGERMDKLRTLLLQKEELLKSLQKSVLGVEHSGDSSSNAVSSSVDSVVSQDLNGHNGTENDPFVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNC4</accession>
    <name>A0ABM0JNC4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0489 protein C5orf22 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0489 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097725.1">
        <property type="nucleotide sequence ID" value="XM_005097668.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859568"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024131">
        <property type="entry name" value="UPF0489"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225">
        <property type="entry name" value="MISEXPRESSION SUPPRESSOR OF RAS 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225:SF3">
        <property type="entry name" value="UPF0489 PROTEIN C5ORF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12640">
        <property type="entry name" value="UPF0489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005097725.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="63555" checksum="F14D781CD7D969F2" modified="2025-10-08" version="1">MKMLLVRRWQRWLRWMFTLLLVFLFWITARLVLFEVFNSPSDQVSNEKRLHSLWSPNPADEMWLPRVKTHRSDETPLVVVEEHYEVLKYWFQAAQFDFIPKSKNMLIHIDGHVDGAVPFNVDSIPWFRFPRSPQEVHNMMQRNDMFIISAVLTGFIDHVIWIWPDWDKESHEGPETDHMIIDFQMGYTKPLALCACWKVRSSEGGTVRQGMKQEDSLDWECRRHNDSEVDIEIGPLMKRSDCQIQGQGVLETLSESKAVTVLKAMEEHDRLGGLILDIDEDYFGCWSDMIPFSEAGIVQEKVDMISELVSDFLCAFSPRQEQDADHYYTAIINLIISLKLKSCDVDRPPGEKRCLKDVDISNYLIENVPNILEFLFSHKKQHVLCAQEEKLNGLRLQSLLAVLTNFSVDQLKSLSKVGICFSTSPSSIHFPVSGILHVCHGDNTPEKTEVTFSLPENKDVIAQTKTLKKILSSIFRKPDVISVCRSIRDGYTPKEYFRMIESAVLTSVSAVYRSVSLKSVHFDGNLLGGALGWPERKQSWNSKLTSFLKFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPG6</accession>
    <name>A0ABM0JPG6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sorting nexin-27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101856895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005098481.1">
        <property type="nucleotide sequence ID" value="XM_005098424.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856895"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13338">
        <property type="entry name" value="FERM-like_C_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01777">
        <property type="entry name" value="FERM_F1_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23070">
        <property type="entry name" value="PDZ_SNX27-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06886">
        <property type="entry name" value="PX_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037827">
        <property type="entry name" value="SNX27_FERM-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037833">
        <property type="entry name" value="SNX27_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037835">
        <property type="entry name" value="SNX27_RA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="116"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="9">
        <location>
            <begin position="255"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005098481.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="57467" checksum="1660DFED6D2C45CF" modified="2025-10-08" version="1">MADSDEDRIPSPSENGGEVNSPRIVTITKTSTGFGFNVRGQITEGGVLRSINGVLYAPLQHVSAVLEGGAAQKAGIRKGDRILEVNGMNVEGATHKQVVDYIRSGGDSLTLTVISVPEQVAEKLEPSDDSSGPSYIDYSERRSLPISIPDCNFMEQYGDKHVVFNIYMAGRHLCSRRYREFDSLHNSLKREFPDFNFPRLPGKKLFQLSEQQLDQRRRGLEQYLEKVCAVRVIGESEMMQEFLAAGDLDEEDSNSQVELKVLLPDKSLCVVTICRSDDTDAVYKAVVAKLHIEEAAEYFYLFESVEHNFERKMLPQELPHNIYIQNYSTATATCILLKKWLFTPSKEMTLTSDPTLLKFLFWQAVDDVNKGIIKTGDKLYELKALKESENALEYLKMVRHLEGHSEVMFPHCACDSRRDGHVAAVIGLTAFKLQACKEDGTTESQVIEFNWKDVKSYGVDDEGMSFNFEYNRQGKKPRLVKIFTPYFYYMNDCFDRIYDELQWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR59</accession>
    <name>A0ABM0JR59_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">28S ribosomal protein S17, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4 5" type="primary">LOC101858033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099603.1">
        <property type="nucleotide sequence ID" value="XM_005099546.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099606.1">
        <property type="nucleotide sequence ID" value="XM_005099549.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825977.1">
        <property type="nucleotide sequence ID" value="XM_035970084.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825978.1">
        <property type="nucleotide sequence ID" value="XM_035970085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858033"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039193">
        <property type="entry name" value="Ribosomal_uS17m_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24088">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24088:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005099603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035825978.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14271" checksum="E01AC685E22A2CFC" modified="2025-10-08" version="1">MASRLMLLGQVVSREVLKPKVVNVRVVEQVFDKHINMFFAEPTDFKAAEGDVKVTLGDLVRIDKLPEKLTVEVEYKVADVVFPIGRVVDPITGRKCRGTRFIDDKAREEEAKRVARTEAWKNYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRP2</accession>
    <name>A0ABM0JRP2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101850483</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005099986.1">
        <property type="nucleotide sequence ID" value="XM_005099929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850483"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF7">
        <property type="entry name" value="PROTEIN CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="12"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005099986.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25255" checksum="06306D9DF9D26D30" modified="2025-10-08" version="1">MRIKGNAIKNVALSTILWSRAVYGVYISVFSFNTLLQYSENSSDVISGNPSSATLVVLVTWAFYITDTLAIFVVGTIFNVMNMSMLIHHLIIFFCSSLMLLHDKGHYFMAVFLAVEVILPFLAIAFTIQKSKVASTSFGRVFEFMFLHGMHMRHGLEIHLWYMTFKYRDRVIAEWPVDLLVSWIILLAIMTFYLGPLWMFGFGKRFYSDIKRVNARKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRS7</accession>
    <name>A0ABM0JRS7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Cathepsin B-like cysteine proteinase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC101847348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100061.1">
        <property type="nucleotide sequence ID" value="XM_005100004.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938906.1">
        <property type="nucleotide sequence ID" value="XM_013083452.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847348"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021109" evidence="7">
        <location>
            <begin position="17"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005100061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012938906.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="36804" checksum="4EF1FE535648A044" modified="2025-10-08" version="1">MHQLFPLCLLVVASVASPATYQMSALGDDMIFYINHVSNTTWKAGRNFHPNELERVKSLLGIDMESNRAYNRIHLKYKEIEVSDDLPKEFDPRKKWPKCQSLSEVRDQSTCGSCWAFGSVEAMTDRICIAGGGAVHLSAEDVNSCCESCGFGCQGGYPTAAWAYYVQSGVVTGGQYGSKQGCLPYSLAHCDHHVKGKYQPCGPVVPTPKCTKQCEAGYSKSYDEDKHFGESSYGVKGVDQIAQDLVSNGPVTALFYVYEDFLSYKSGVYKHTTGKYLGAHAVKILGYGVENGQDYWLVTNSWNEDWGDKGFFKIAKGSDECAIEDMIVTGNPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRW1</accession>
    <name>A0ABM0JRW1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101859414</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005100112.1">
        <property type="nucleotide sequence ID" value="XM_005100055.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005100113.1">
        <property type="nucleotide sequence ID" value="XM_005100056.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859414"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14296">
        <property type="entry name" value="UBA1_scUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF29">
        <property type="entry name" value="AMINOACYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="4">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005100112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005100113.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="22261" checksum="15685B4412C339A8" modified="2025-10-08" version="1">MSSGNAGSDNPGSGAGQLLFQPNEEAVAQIMSLGFSRNAAIRALFYTGNQTADQAADWLLENNDKNLDTPLETDLQGTSDSSDEDEFLTTDTFKMVFVVNMELQMGVGKVAAQVAHAALSLFRSMMEDEVKAEMIMAWGHLGETKVVVRGDSTTQLEMLAVQAAGLQVDHYLVQDAGLTQVTPGSKTVLAVFGKVDDVNRVTGSLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSX9</accession>
    <name>A0ABM0JSX9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Zwei Ig domain protein zig-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8 9 10 11 12 13 14" type="primary">LOC101849621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100752.1">
        <property type="nucleotide sequence ID" value="XM_005100695.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939286.1">
        <property type="nucleotide sequence ID" value="XM_013083832.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826244.1">
        <property type="nucleotide sequence ID" value="XM_035970351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826245.1">
        <property type="nucleotide sequence ID" value="XM_035970352.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826246.1">
        <property type="nucleotide sequence ID" value="XM_035970353.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826247.1">
        <property type="nucleotide sequence ID" value="XM_035970354.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826248.1">
        <property type="nucleotide sequence ID" value="XM_035970355.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826249.1">
        <property type="nucleotide sequence ID" value="XM_035970356.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826250.1">
        <property type="nucleotide sequence ID" value="XM_035970357.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826251.1">
        <property type="nucleotide sequence ID" value="XM_035970358.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849621"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021112" evidence="2">
        <location>
            <begin position="38"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="71"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="184"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012939286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035826246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035826247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035826248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035826249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035826250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035826251.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37046" checksum="C723D60E39DD285A" modified="2025-10-08" version="1">MKLAGPGAPLTSLCSLTTVTSFLAVLVNIAMVGTTSGQHHHDIRHSRHYLKHPPHRFHDFDYEDATVVLKPEFLNTESNISVRIGDSATLPCAVRNLGTKEVVWRLYPKNAEPLVLTVGTFTWVRGNDIQVEYKMEEGFITRWDLVMRNVQMEDEGTYECQVTDKVPIRTHVHLTVKPMPASNPSVVLTGEEFVDSNERIKLVCNATGGDKIPEDIDWFKDGTKLDSTKSRDPKIVLTKYMSIEDVALISELTIEHAGFSDSGNYICRSSDRKIDSLKVTVLVAPNNPNVKRGTGAQVEEQKDDNGGVSMTSSGVIALLLSSVVATVISRTLPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JT90</accession>
    <name>A0ABM0JT90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">rRNA-processing protein FCF1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101856582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100953.1">
        <property type="nucleotide sequence ID" value="XM_005100896.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856582"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005100953.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22835" checksum="0F7E49B8C31DB5E9" modified="2025-10-08" version="1">MGKDKRTKKFAQVKRLLSLKDSRLKAKDRVKKRKRKANPENISVRELPQSSSAMYFSYNTQLGPPFHIIVDTNFINFSIKNKLDVVTSMMDCLYAKCIPYITDCVMAELEKLGRKYRVALKIAKDSRFQHLTCLHKGTYADDCIVRRVTENKCYIVATNDKDLKKRIRKIPGVPIMYIAQHRYSIERLPDAYGAPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTC5</accession>
    <name>A0ABM0JTC5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101851047</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101015.1">
        <property type="nucleotide sequence ID" value="XM_005100958.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851047"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101015.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21266" checksum="D3B832284D517629" modified="2025-10-08" version="1">MAFQSRQSIVNLPLILLLVYLCPFIAGDNAFYKEMPKELRCSGCELTVKVLDQMLIRDTGNTESRVMKALEKVCEEHRFSISEYKPQRIVKVCEFIKKKHGDELKRELVKYFSQSKRSTYLEFVQHFCLDVTRLCAGISHKIKPHEDKEDAILHFDSESHGFTVMPGRNFKMPRPIAEGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTN0</accession>
    <name>A0ABM0JTN0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101862806</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101230.2">
        <property type="nucleotide sequence ID" value="XM_005101173.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862806"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101230.2"/>
        </source>
    </evidence>
    <sequence length="200" mass="22159" checksum="A5150ECF76FA7C65" modified="2025-10-08" version="1">MEPTKVKSTPVESIQEELQEEAMTEEKIADVEEKPKKKTKKQFVSSGIQQGGAVAARAGDFFARLGALMVLVVATINTCLAVVTNFVDEVYWAAGLYLGLLLFIHLPVLIFMLVMMLKARVAGVINRVRPRKKTEPIMVKESPVIVNSEGVDNASKQGKKKSDESKKDKKKTDDTRLRNIENNKTKKVGQINKAFDVGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUF6</accession>
    <name>A0ABM0JUF6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101845857</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101752.1">
        <property type="nucleotide sequence ID" value="XM_005101695.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845857"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046961447" evidence="1">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101752.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20274" checksum="27CABEE80CA98F1B" modified="2025-10-08" version="1">MQFLALFLLVAPVAYTVAAPDPSTICLPEKSTARVFGLIQKFQANVSIDFSQNKVAAVTELGTRVSDLNTNYTYLIDATGACTREPLPIFGYITRCLPPSSVFLGEVFEGFVNKVTLNGWLIPVNKDFNVTLLTYTEPGQTDSYFVLRRDDTPQGQRIGFVSNPVASIADTTVFNVPAVCPDKPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUF8</accession>
    <name>A0ABM0JUF8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">LIM domain-binding protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9" type="primary">LOC101846513</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the LDB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101755.1">
        <property type="nucleotide sequence ID" value="XM_005101698.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101756.1">
        <property type="nucleotide sequence ID" value="XM_005101699.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101757.1">
        <property type="nucleotide sequence ID" value="XM_005101700.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939915.1">
        <property type="nucleotide sequence ID" value="XM_013084461.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846513"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041363">
        <property type="entry name" value="LID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17916">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51957">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIM interaction" evidence="4">
        <location>
            <begin position="380"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005101755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005101757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012939915.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="51463" checksum="95FD461188378CFD" modified="2025-10-08" version="1">MNPNLNMPTGPGPGPGVSMPGGPPMPSGPMPPGPMPSGPMPPGAMPSGPMPSGPMPGPGPSPIPGGPGPMPPGVMPGGPPMPGQDPFYSSPFSTFYRRPTPYMGQPDYRIYELNKRLQHRTEDSDNLWWDSFTTEFFEDDASLTLTFCLEDGPKRYTIGRTLIPRYFRSIFEGEVTDLHYILKYPKESFHNTTITLDCDHALMVTQHGKPMFTNQVITEGRLILEFTFDDLMRIRSWHFAIRQHRELIPRSVIAMQQDPTMVEQLSKNITRMGLTNYTLNFLRLCVILEPMQELMSRHKAYGLNPRDCLKTTLFQKWQRMVAPPGKESARPPSKRRKRKGSQSTNAGSGNINNRDAPPSGKQKRSPGPQGFNLGSTVPGDVMVVGEPTLMGGEFGDEDERLITRLENSQFEPTNNEDNNADKFHNSPAVQQSPWGGDKNTPQPSTATTTPTTNTPLTEAEIKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVL8</accession>
    <name>A0ABM0JVL8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101855960</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101855960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005102584.2">
        <property type="nucleotide sequence ID" value="XM_005102527.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855960"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005102584.2"/>
        </source>
    </evidence>
    <sequence length="260" mass="29620" checksum="7BCEE824FCFEAE34" modified="2025-10-08" version="1">MEKPLFRVDNAKSQMSVCKTCCKVIAFRALRIGVTDYNEGRLNDLTCSPGWNHVDCFYRRSSYLWWMKHLVRNYPTHLVGYNALSNENKSRIKKHMVELEGRDITRPRCSDPEYFYSDSEEDEDFTPAPTKQRKMNEITAQKDNKKTKKSAIPGAASALESEDGPSAKRKNSKKQKMGHIDSNKDGGTHWTPQKELRPTASKDDTLEKKPEAKNNNNTVPGDEDINVQVAYISGDIYARVKTPLSYNGHFVSLISYQAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWD7</accession>
    <name>A0ABM0JWD7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tumor suppressor candidate 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101853475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103086.2">
        <property type="nucleotide sequence ID" value="XM_005103029.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853475"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046848529" evidence="10">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005103086.2"/>
        </source>
    </evidence>
    <sequence length="338" mass="38724" checksum="E00CF14F46617EFE" modified="2025-10-08" version="1">MYFRWQIKMAAYIQLVLLWGFIALLTASVLAETKKKEESLGDKVHQLMEWNNKKSIIRLNGDKFKQYVRTAPRNYSVVVMLTALQPQRGCSVCRQANDEYQILANSWRYSQHYSNKLFFTLVDYDEGSDIFQSMKLNTAPVFMHFPSKGKPKKGDTLDIHRVGFAAEQLAKWVGERTDVQIRVFRPPNYSGTVALALLFATIGGLLYFKRNNLEFLYNKTSWGIIALAVIFAMTSGQMWNHIRGPPVMHRNPNTGQMHYIHGSSQGQFIMETYIVMLLNTAVVVGFIMLNEAQSMKGDPSKKRILSLVGLGCVTIFFSLLLSVFRSKYQGYPYSFLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWG2</accession>
    <name>A0ABM0JWG2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103138.1">
        <property type="nucleotide sequence ID" value="XM_005103081.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846083"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005103138.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42888" checksum="4A57042A5EE3311F" modified="2025-10-08" version="1">MTNTNYVHSDNTEPIVIDNGSGMCKAGFAGDDAPRCVFPAITGRPKYQTVMAGMGSKDCYVGDEAQARRGMLCMHYPVEHGIVTNWDDMERIWHHTFYNELRVAPEENPVLLTEAPLNPKANREMMTQIMFETFNAPAFYVGVQAVLSLYASGRTTGVVMDSGDGVTHFVPIYEGYALPHAIKRVDLAGRDLTHYLRKILNERGYSFTTTSEMEIVRDMKEKLCYVAMDFDQEMSAAAKSSSVEKSYELPDGTVVTIGNERFRCPEVLFQPSYTGRESAGVHELLYNSVMSCDIDIRRELLHSTILSGGTTMYPGLADRMQKELEDLVPPSNKVKVIAPPERKYSVWIGGSIMASLSTFQQMWISRQEYDECGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWR7</accession>
    <name>A0ABM0JWR7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC101857424</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6" type="primary">LOC101857424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103359.1">
        <property type="nucleotide sequence ID" value="XM_005103302.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826946.1">
        <property type="nucleotide sequence ID" value="XM_035971053.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826947.1">
        <property type="nucleotide sequence ID" value="XM_035971054.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826948.1">
        <property type="nucleotide sequence ID" value="XM_035971055.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857424"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035826948.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="18431" checksum="5DAC777D6F14ADBD" modified="2025-10-08" version="1">MSLPPQSTSLGKVGLSISAIGLLIFIVGFACPYWLTTTIEIPVLGANHINVGLFKACNTFTGCESSNEPKDWQYATAGLEVLGLCLSLATVSGAILYVCVLNTTWVAKLKWSFIATGMLAGSAVIGGCVVFVLNRDNVSDLTAGIEYDIGWSFALGAVGGILQILSAGLFIVDCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWY6</accession>
    <name>A0ABM0JWY6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101852493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103515.1">
        <property type="nucleotide sequence ID" value="XM_005103458.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852493"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005103515.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40110" checksum="EFD83C6205444776" modified="2025-10-08" version="1">MMPELAFNIDHGYLEGLLRGFKGGILKQSDYLNLVQCETLDDLKLHLQSTDYGNFLANEPSPLTVSVIDDKLREKLVVEVEHMRNHALQPLSGFLDYIKYSYMIDNVILLITGTLHGRPIHELLPKCHPLGTFDQLAAINLANTSIMLYNAVLVDTPLAPYIKDCISAEDLDEMNVEIIRNTLYKSYLEDFYNFCKKQGGATAEVMCEALAFDADRRAFIITINSFGTELSKEDRMKLYPRCGNLYPSGLKLLGDCDDFDQVRAVAEYYPQYKELFDNSGSNPGDKTLEDKFFEYEVKLMKKAFMQQFQFGVFYAYIRLKEQEIRNIIWIAECVAQRHRAKIDSYIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYJ4</accession>
    <name>A0ABM0JYJ4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101857045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005104552.1">
        <property type="nucleotide sequence ID" value="XM_005104495.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857045"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005104552.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21799" checksum="71854F6822B3233F" modified="2025-10-08" version="1">MVQAWYMEITNETDFRQPNKTNPPRHVTLEELYEKTGMECISIDANSWQTNQEYANLKVERGVTSEDVVELSRVKLDNFEERMKRFFVEHIHTDPEIRYVEAGSGYFDVRDRDEKWIRIWIQQNDLIILPAGIYHRFTLDTINDHIKLQRLFLGNPAWEAINRPEADAHHVRKQYAMKMAPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ63</accession>
    <name>A0ABM0JZ63_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101855039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104978.1">
        <property type="nucleotide sequence ID" value="XM_005104921.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855039"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054716">
        <property type="entry name" value="Sol_Rieske_ferrdox_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF19">
        <property type="entry name" value="SI:CH211-212D10.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22543">
        <property type="entry name" value="Rieske_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005104978.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13659" checksum="FF1030875E7CF4E5" modified="2025-10-08" version="1">MAKSPQNLDSDLQWHLIGGVEELKQKVCRKVYMQGGQGLALFYVAPDKFFLTNSTCPHARGPLEQGDIEDIGGSFKVVCPLHYYSFDLVTGQSATGLTLRTYKTEVREDGLYGLTPFPVSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZF6</accession>
    <name>A0ABM0JZF6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="10">2.4.1.132</ecNumber>
            <ecNumber evidence="10">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101859036</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8 10">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9 10">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="10"/>
    <dbReference type="EC" id="2.4.1.257" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005105163.1">
        <property type="nucleotide sequence ID" value="XM_005105106.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859036"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="11">
        <location>
            <begin position="210"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005105163.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44883" checksum="E5441DBDDCB10CDC" modified="2025-10-08" version="1">MGRIVFLHPDLGIGGAERAVIDAALALKSRGHQVEFVTAHHDPSHCFPETKDNTFTVTTAGDWLPRSVLGKCYALCAYIRMIYAAVYLVFFSGIKYDAIFCDQISACLPFLKLASAKVLFYCHFPDMLLTQRQSMLKSLYRGPIDYVEEKTTGMADCILVNSKFTAKVFHDTFSSLRHIQPQVLYPIPDFSAFDKAVDPPSDDLIPSGVKTVFLSINRYDRKKNLPLAIKAFGKLLKEHPDANTHLIMAGGYDDRVTENVELHKELVLMAKELGLESSVTFLRSFSDSQKRTLLKYSSCLLYTPENEHFGIVPIEAMYMKCPVIAMNSGGPLETVAHESTGFLCPNDSDLVADAMYKFIDTPDLSKSFGEAGKKRIETMFSFIQFTDKLDSVINELLTGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0S4</accession>
    <name>A0ABM0K0S4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Selenoprotein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101845024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the selenoprotein M/F family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106052.2">
        <property type="nucleotide sequence ID" value="XM_005105995.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845024"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.50">
        <property type="entry name" value="Sep15/SelM thioredoxin-like domain, active-site redox motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038219">
        <property type="entry name" value="Sep15/SelM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039992">
        <property type="entry name" value="Sep15_SelM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014912">
        <property type="entry name" value="Sep15_SelM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077:SF6">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08806">
        <property type="entry name" value="Sep15_SelM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0711">Selenium</keyword>
    <keyword evidence="5 10" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046922397" description="Selenoprotein F" evidence="7">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein F/M" evidence="8">
        <location>
            <begin position="80"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005106052.2"/>
        </source>
    </evidence>
    <sequence length="153" mass="17512" checksum="9741F429F7DDE808" modified="2025-10-08" version="1">MADWIQLVSFLLMFMVYVGDCSLDFVRECSLKGFTNNLMCSTCLKMDDFNLGAIKLDCLECCQKDKEEEAGITKYPFAELAVCGUKLGRFPQVQAFVKSDRVKQFPGLTVRYVRGADPVIKLLDKNHEVVETLGIDKWNTDSVEEFFQEHLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1B9</accession>
    <name>A0ABM0K1B9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein Rab-1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106429.2">
        <property type="nucleotide sequence ID" value="XM_005106372.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853026"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106429.2"/>
        </source>
    </evidence>
    <sequence length="220" mass="24428" checksum="742082D7221F539A" modified="2025-10-08" version="1">MSKVNNDSQLLEPDFLLKLVLVGNTGVGKTCLLLRYTDNMFSETFITTIGVDFKIKTLDVEGGTAKLQLWDTAGQDRFKSIVSSFYRGADGLIVVYDLTDLDSYEALPRWLSEAERYGSPNCVRMMVGNKVDMTAKRVVERQTAQAFADRLGMEYLETSAKNASNVQEAFTKLAHSILEKKRASGLLVSRDARKDGEIIGLTKEPSQTSWCWGGESCSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2D0</accession>
    <name>A0ABM0K2D0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MKI67 FHA domain-interacting nucleolar phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005107105.1">
        <property type="nucleotide sequence ID" value="XM_005107048.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848773"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005107105.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30475" checksum="0DF73FE93F5A3961" modified="2025-10-08" version="1">MAPTTPKKKTEVVTDEDRQPGVIYIGHVPHGFYEEELKKYFSQFGKVLQIKLSRSKKSGKSKGYAFVKFQYTAVAKTVADTCHNYLFFDKLLKCEYKKPEDLHKDTFFSYDWRPNIKPKRLHNTAKSEVKVQRSAKRSSRRQADKLKKLKELGIDLQLDDVLSMPVTNVTAPPKSEGSGSTPAAAGKAGRKVTPSPGASVARTNKTPKTTVSSNGTAVSTPPPRTLKRKRPGSGAVAVAKSRETKAAPKKALSGTEKTGVKMGKNTPKRSKVKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2P7</accession>
    <name>A0ABM0K2P7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/threonine-protein kinase tousled-like 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101851218</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107370.1">
        <property type="nucleotide sequence ID" value="XM_005107313.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851218"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13990">
        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="423"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="218"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005107370.1"/>
        </source>
    </evidence>
    <sequence length="761" mass="85574" checksum="69AF09394588C4F0" modified="2025-10-08" version="1">MSCGSGGPPSWTAAGSHSSQSPHLVRHSASREGVMENIHVDRRKQELLEARLLGGRFQPLVMPQPAAEQQQENSNVSSSGSVDKEVGEGQMATPDKGKAAGDKKRKRKAPVVENPVAAKRAETNGKKINEYFKQNQSPSRTGQPQNASGAKSPSPQAFGNIVPHSPSNSSNSVADIFSLPNRTSLTLSIGINACSKCVQTDFSMAHLQAMESQSMSDMEQKDTRIDELIRQNDELKRQCTAQNKLLEKHKENLQKCLEVNKSLLIEKSTLEKKTTRQKCMENRLRLGQFVTQRQGAQFVENWVDGWAFQDLMKQQERITADKDDIDKQRRLLIKRKPPTALGKNAKHDNFLKPGEKYLTLAEFYEQDEILKLRAAALKKEDADLQLEMEKLERERNLHIRELKRIHNEDNSRFKDHPILNERYLLLCLLGKGGFSEVHKGFDLKEQRYVACKIHQLNREWKEDKKANYIKHALREYNIHKTLDHPRIVKLFDVFEIDNNSFCTVLEYQKGNDLDFYLKQNKSIPEKEARSIISQTVSALRYLNEIKPPVIHYDLKPGNILLGSGSVSGEIKITDFGLSKVMDETNFQPEIGMDLTSQGAGTYWYLPPECFVVGKTPPKISSKVDVWSVGVIFYQCLYGKKPFGHNLSQAAILEENTILKATEVDFASKPPVTQEAKNFIRRCLQYKKELRPDVMQLAADDYLKPAQLKSKTAADGSLHTSMGSHLGSGGSVMLVTNAQGSAITNSLSASQNPSFSFADKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3H9</accession>
    <name>A0ABM0K3H9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101859041</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005107910.1">
        <property type="nucleotide sequence ID" value="XM_005107853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859041"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005107910.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43556" checksum="2BC8ACA09380A1B1" modified="2025-10-08" version="1">MATRPDPNVDISHFEVIFSARTAAPFSGDNPEIAGSSSSQGLSSFEKRQKFEKRNAERLQRVQEICQSKESPTYIRPVYFLSDPDRQLLQCHVAKVGCSFWTSVFRFLHLKAKGQLGGYRSPLDIPRFEVHHAKDHPEELYPRRVLAAEGPESKSVRNPYSRLWSVYLDKIVTLSLCTPTISFTEFLRNVGISYNNNRHYMPVTMMCNPCIFKPDYIGFQETFSDDAFHILQAVGLDHVAPKINQSVYQEHEIRSLTEYAYSIPDYWFDRQTNICQNKSTEMAMNLWRVFQFNGHIRSDLPFPRDLEEYTPASVTKMILDVIQKFPISKKEAKEQKLKYMTTAYKEVPADVIEGVQKKYKYDFLMFGYDANVDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4N5</accession>
    <name>A0ABM0K4N5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101860200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108676.2">
        <property type="nucleotide sequence ID" value="XM_005108619.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860200"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042838">
        <property type="entry name" value="KIAA1958"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="5">
        <location>
            <begin position="378"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="672"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="799"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005108676.2"/>
        </source>
    </evidence>
    <sequence length="1010" mass="109879" checksum="044F5DC641D7C72E" modified="2025-10-08" version="1">MNMEQTNVSTSRLNEECNPESPPSERNSVNIDASDGDVSAATATSTAVHEDEISSTNAKGLVSEGTPMPVVQSSLNEISSSEKTKTTGDLDTADQNKRGGSPETTIPFYVGNGPVFPARHNRELQPVSSNTSADSGSHPESSETDVHDIDNATRKVLLSYIDTAEEGINMKKENSNETRAEPSSQSQDPVVENNVNNDTATDCETKEGPSASNTETENESLAPLSASFFNCQYQTPSWIDDPLIGVPPCAMENKNTHRKTGADMRILTAYMRSLNEMRLPEAIPPSELDKYLSSFFLVVRKADGSEYEPCSLRAMLASIERYLRFKNYPLSLTRDSAFSNMRNVLKLKQQTLRSIGKGQKAPSDISPSSLAREGKIAHLFKSQEMGPYTPSSVVFTLCFYFCMYLRIRKSTENKKLLWGDIILCKDESGREFLTFSSQMLRRSQSSSKGNSRQRTYRVWADPSCPEKDPVTIYKFYAQKRPASMNTNFAPFYLGINVLYPTQGQLWYRPAAMGINKLNEMVRQIREITGIRNTTEFNSEPKLSDKPGTEVNGGTQDGQSPSNESADRQDSESEIKTEVLDEIEEDDGSSMTAMDFSQEQQEHPLNFNQSSHAVPPPSRQTLAALGNMAQAVYSDGESNDSFSHQSFPAKTNGDIGADSRNDREFEHEIDLTKMNSPDSPLNCSTKDRSSYTAETAGRQNSSDAIGVEEAKLHLMNIMRRLEPADIIQFNSWLKGVKFSSDPFSGQVVCQEGEDTKDSVTVKTSSSNIGSLGANIILNISLSPQALQGEGPITVTAQTSIPPEQQQRNNSSSIGSLNGSSSSSSSGKGNPLNNSSRHGTTSAASASKNPLPTFPHNATAPTEQLVSSDKPLDLVTSPVSRAGKAASSSSSSSSSSSSQQQQGKMSRPHSGSNGIFPAMSGSSSSRGDSPLAKRLRLSAEQAEAYTSASIMASLSSANFLNERLRFQLMQAGLHMGDYNVDPHASAGLMDLANSEALQSQLLQHYGIKSEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6G3</accession>
    <name>A0ABM0K6G3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109861.1">
        <property type="nucleotide sequence ID" value="XM_005109804.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857606"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="6">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="4">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="5">
        <location>
            <begin position="287"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005109861.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="42222" checksum="010AD3379C542BCE" modified="2025-10-08" version="1">MSTTIRSAEDLVKDACAAFEKRFGEKPSVAAKAPGRVNLIGEHTDYNAGFVFPMALPMVTVIVGRPTASGTCRVETLAAADDPLYTEFPSKKLEPGKPKWCNYVKGVAAQMPGNIPSFDAVVTTSVPLGGGVSSSASLEVATHTFLEQMGGAGENDTEVDKILRCQKAEHEFAGMPCGIMDQFISVKGKAGHAVLIDCRSQEGRLVPMSDPSVVVLVTNSNVKHELTGSEYPTRRRQCEEAAKLFGKESLRDASEADLEAKKSEMNEEMFRRVRHVITEIKRTDEAATALENGDYKTFGNLMVASHNSLRDDYEVSCKELDQLVEFAMELQSEGVFGSRMTGGGFGGCTVTLLKASAVDKVIEHVAAKYSASGNKATFFVCPPSDGATKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6S6</accession>
    <name>A0ABM0K6S6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein canopy homolog 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101848785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110075.1">
        <property type="nucleotide sequence ID" value="XM_005110018.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848785"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042415">
        <property type="entry name" value="CNPY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341">
        <property type="entry name" value="MIR-INTERACTING SAPOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341:SF2">
        <property type="entry name" value="PROTEIN SEELE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045468269" evidence="3">
        <location>
            <begin position="26"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="4">
        <location>
            <begin position="31"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005110075.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25050" checksum="AE5A76D90D8FA8C3" modified="2025-10-08" version="1">MMLGDSAMYLLSFLLLLTFVDVSQCGKNEKYCGVCRALISEANWAVSQVDPKKSIQVGSFRVDPKGDLTVKEKKYARSDSHLEEIFEDICEKLRQYGELTNEDGSKSIVRTSGFWGQRLETTGLNLDREAGKMLKYKCDDFLENHEEEMISLLQRENIPDYEKIICGEETKVCSMEDLASPMITLPEAVDEVNSDNDGEAEEEEEEEEEDDDEEAEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6U2</accession>
    <name>A0ABM0K6U2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855982</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110104.1">
        <property type="nucleotide sequence ID" value="XM_005110047.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855982"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110104.1"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117359" checksum="3626388F6E705EA7" modified="2025-10-08" version="1">MNFFKSLFLQDEHFVLTRKKERIVRLQEWPFSSFAAKFVSEHLADEKKRKKKKKEEKVSTKAEGRSMMEFMYCIPDLEVFIDKTIKKCLLEYDLDSKDTEALLDDLEKTWPDSPNQKARPLDKTALKDCNDNTTTTKYDKGRGLTGHVTTTAGATGGGGGDDFSHDVKTEGWSLKTQIKQENLVTVGDVGGKTVGQEVDDDVKPPERKYSRLSSQSDVISGPPADAGQDFDGGVCRVSERQERGSSSSPELGDGKNLSSRHPKLKSRLQQRYFEGKQDVGKGVPDNNSHSNSNSTANGDSEQEGSEVDHMKSGNLDLLARAANLHTTASEQRKLLEERSRGAHGVRRLHSDSEGKEEFEGVEEDELVAGLPPPDMPVLIRQDALMSPVGVVDSSLITDDGRDLRAHHHDSNSNQSVNLSHKNSARESSPPNHYRNGDNRGEIFANSFPHFMPSGKASARNVVAHPTRKMGLLEEELLKTDSNLEQRARVLLQHYQNGYHAARESVVREMSLSESEDIANGAVLSARGEGENGKPKRAPISAQELIKIRAAENLLRQHYQNNNSSNNSSGINGYSSSNGHHHHEQHNSEPRRHQNESGHRVNGRGSPSPPGSIRHHLGSHPHKQQQQQQLQQQQQQQQRHPQHHMAIHQNQQSRVLQQHGESGLLSSRREGGSQRSHIGQHRDIYNHHHHPTRFGPTRSQPISSQSSRIASIIAEELQKEDSDCDHDRGTCKNVPFIHRIMSEETASARPAVYRGRRRSRTSSATQGNMPASQLRQSRSPLSPPAAVATYATNNTIVERVARNYLNEGQIESLLRSQITSQAEPGQVKSHHQHNHHRHHHHHHHQPNGHHHDDHHQQHREPSTNANVPSFLTHAHSAKVLVPSHLRHQNGLTPNVRDVIPDDEQPEDLSLKSRKRKLNEIEETDAQILRSSYFLGSNPDSPVSEPSSRGYFSSPTSPLTSVASSPTLLIGSPHSRKSASPSNSDRECDYTTTSDLPRSVLKASGHWEKRGHVHGLDLAHTVAIDNKILAEKRRLEALARWSNTRDNEMDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K710</accession>
    <name>A0ABM0K710_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101847224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005110237.1">
        <property type="nucleotide sequence ID" value="XM_005110180.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847224"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01790">
        <property type="entry name" value="Ubl_HERP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005110237.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="51866" checksum="24719F535D304479" modified="2025-10-08" version="1">MDLPGDIPVTLVIKAPSQRMDDQVVDCVLSWTVRKLKEHLETVYPSRPKYNEQRLIYSGRLLQDQLTLKDILRQYDSSSTSNRYTLHLVCSSSNDSSLTAKSSDNVKTSVKNPVPSVPSPQPETVSSTTSPVAPTDVPTSIPPTETGTDGLRYRGTPEASGNTQPNFAAYPGMYTYLGFHPGAYNPYMSAASAFSPATAGAEGYTYNPEQYMAMMQQMYSQYMMQYMQYYQNVYSPDQASALAANAFMQQGYPSPWLQQPQQPQPAAPAGAQAPNAAGDGAANNRGAGAGRQNVRMNAQGGMEEDEDEDGEPRDWLHHTYFIMRFLTFMGILFFYSNLSRFLVVFSGSFAIYFLQKLRKYMQRRDREQQQQQQQQQQQQQQQEEPPQEEQQEDAVNVQAENNGNGGEGDQSAPAQNTEEPGQAPANGQVEEEEGGRVSRMFLFACNTVQAFFTSLLPTPPELLDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K729</accession>
    <name>A0ABM0K729_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855983</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110276.1">
        <property type="nucleotide sequence ID" value="XM_005110219.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855983"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047354515" evidence="1">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110276.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18004" checksum="F2212BFD879A5ABA" modified="2025-10-08" version="1">MGASAILFGGLLLTVLTLLVVDGRQMCWSCQFVFGGRGEECAEAPGNWTEGNPRTRCEGYCVTLATFIADTGELKYFYRGCVVDKAKRKQGCVRVGTTDDCYFICGDGDHYCNDKSLPTSPYVEEGSDGNGASGIFIFGLTHTVHLFLAVLATHSLIKLCYSRSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8M6</accession>
    <name>A0ABM0K8M6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein vnd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005111423.1">
        <property type="nucleotide sequence ID" value="XM_005111366.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860859"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF82">
        <property type="entry name" value="HOMEOBOX PROTEIN VND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005111423.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33139" checksum="E6E3068E47151CC2" modified="2025-10-08" version="1">MSVADDSMWGVGDLGSVPPPSSHPHTTSTTSGSPHSHDPHSDNASQHESRHSNAATPIKDCYDDDDNDDEDDDSKSDSGTPNDKSGKDTGDSHSDTNTGDPPKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASIIRLTPVQVKIWFQNHRYKLKRSRQEKGLADLNPLPSPRRVAVPVLVKDGIPCQRPSMNASLKSAEHQHAHLSMQTGMANMGMSMNPSGLNHMGSMNGYGNMAPGTAQAISSTLANSMSMNMNMSCSYNNSISHLNVPSVNNMNVLPGYSHPLLQPQTRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K992</accession>
    <name>A0ABM0K992_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Corrinoid adenosyltransferase isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111913.1">
        <property type="nucleotide sequence ID" value="XM_005111856.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858757"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="5">
        <location>
            <begin position="37"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005111913.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26014" checksum="2C0348E5F82613DE" modified="2025-10-08" version="1">MSFTRIPMLGLFCARIGTRHLQGVCALTSPVRYYNKIYTKTGDKGTSVTFTGVRKPKDNAVFKALGTTDELSSAIGLAAEFCSEAGHPMEDRLQIIQCVLQDVGSNIATPLSSARNAHLQKVKFNHKFIHEMESWIDEMTEELPPLKNFILPSGGKSACSLHLARSICRRAERSMAPLVRDEEIDPETLKFVNRLSDFLFTAARYAAMKEGKEEKIYRRIGELPSQDDKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9V0</accession>
    <name>A0ABM0K9V0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005112388.2">
        <property type="nucleotide sequence ID" value="XM_005112331.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848714"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005112388.2"/>
        </source>
    </evidence>
    <sequence length="389" mass="45271" checksum="4623A70B89C234FC" modified="2025-10-08" version="1">MADGMDQQTLALQIQEQEEREERQHFARVINSFKYYKLHCLKRLQMSKVSYLQLNDQQKSRIPSYMDNLDTIQTCVIHNYEVIKLMLQDCQYMFLNKDECITDADFERVKKTDCAPPTAEEMNKVKTTLKQIVRDWSEDGRAEREACYQPVMHAVLTRLGLSPHRSRKPSEVKILVPGAGLGRLVFEFARLGYSCQGNEWSMHMLLASNFILNRCQERQSMVIYPWVNQFTNNLATKDQTRRSMFPDISPLQISSDADFTMVAGDFTKIYTEPNTWNAIVTVFFLDTAHNIIEYLEIIYNILIPGGYLVNLGPLLYHWEGMQKEMSVELSYEELRKVMLDIGFEIEKEEMNVRCSYTQNPLSLMQNFYNCVMFVARKPIPRGAHHDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAH9</accession>
    <name>A0ABM0KAH9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Trace amine-associated receptor 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005112867.1">
        <property type="nucleotide sequence ID" value="XM_005112810.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857087"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF424">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005112867.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31841" checksum="5B0712298738CE43" modified="2025-10-08" version="1">MLVLKTPSIRTQGNALVASLAFTDVIMGVVYVIYSCLILTSTPSGDWHFFSDRFLVVFGSSLTDVSAVHMALIALDRYIFFVHPFVYMKRINKKLTTFVISGAWMFGVSLTGVNYIVYIAKEDIYATCNFSHTPLSYLYNVTFLIYLAVNVVAFVCYFRIARLIQQHRRIIAANREMVRSRILLTTSDPSAHSQDTSNISENHMKRLRILITTFSVFFVCKMTSLSVFGVEQYLTILPDVLVFIVLFFIPISSTVNFLLFTLMDKHFRRALTKMASCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBH4</accession>
    <name>A0ABM0KBH4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113572.2">
        <property type="nucleotide sequence ID" value="XM_005113515.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859151"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113572.2"/>
        </source>
    </evidence>
    <sequence length="145" mass="16901" checksum="AAF5BE0A1755CF37" modified="2025-10-08" version="1">WVKFARGNRYSAAEHMERYKEECQRIFDLQNRVLASTETLSTDEESTSGEDSDFEEMGKNIESMLSNKKTSTQLSREKEEAERRELQRMLKGEIADKDKKSKTSNSKEDDMMVDFSFPFLSIRRQLSLASHPRPVGRCGRLFFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUW7</accession>
    <name>A0ABM0ZUW7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934952.1">
        <property type="nucleotide sequence ID" value="XM_013079498.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011100"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012934952.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="17353" checksum="651154DCD4D502DA" modified="2025-10-08" version="1">MTSDPGRVLTTVFWLDIMNGQRVLASVLADVKLGASLHRLLVVKPCDLGVIFVNLAGESDVIVFRSGGVGEGNGEVCLHLLDSEWSSALFALNPHCVLSAGVEWGVLESECVGLPVHLSDDQVAQGQLLTVLEPGGREVRLGDLALEGHGLALLAGLGLKGYCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVB9</accession>
    <name>A0ABM0ZVB9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011150</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935239.1">
        <property type="nucleotide sequence ID" value="XM_013079785.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011150"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935239.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12456" checksum="C9F3DC2BBB2AB090" modified="2025-10-08" version="1">MVQVLWPIAVVLAGTAWSAGIYIAYKIKKGKKINPKVPLVCMASGIIAGVLAILVFTMYRSGVYRKHSGYSLHFCVYFVNSCCCLWISSSIMIRNAARCTIGLTGQVISTCNTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVR4</accession>
    <name>A0ABM0ZVR4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neuroligin 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935541.1">
        <property type="nucleotide sequence ID" value="XM_013080087.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857011"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="2"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935541.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="52713" checksum="17D2D4837C26FED0" modified="2025-10-08" version="1">MEFGNECWQRIRNTSVLSRSEDCLYLNVFTTVPKASSSPQPVMVWIHGGGYTAGAASQYDVISLSTKGVVVVSINYRLNVFGFLSTEDDVMPGNYGMLDQIAALKWVRKNIAGFGGDPNLITIFGERAGSGSVSLLTLSPLAKGLFQRAIMESGVSISPWGIQHAGNRVSARTMSRLIGAAVECSDLDDSSKLLSCLQGVDANRLFRVYDRVNRAVDAGMTMCPRVETTFGFLPDLPITLLSRGQFNDVNTIRGFNSDERSSVAVPFSAAPARSAEQIVDKTIHAWLKQFSELDQATLFELVKSEYITDTSSEKNMLNGALNAQNDIVFVASTLTEINKVTQTASNGPKHYLYEYSHESSFSPNPQWNSATHGGEVAFVLDVQRGQPYSAGIIPTSEDILVSQQMIEMWTNFAKTGNPTSSVPIGGAMWSPYSPETPNYLFITSQTKQKMWQRPRVVDFYWAVLQKLDGSAPSAPADSIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW00</accession>
    <name>A0ABM0ZW00_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 3A41-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101859773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935676.1">
        <property type="nucleotide sequence ID" value="XM_013080222.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859773"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012935676.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42089" checksum="77D0AF4EA1BD7602" modified="2025-10-08" version="1">MYPHIVRNTQLLLEHLKEKHERNEPVELRDLLSAYTMDMIASTGFGVEINSLKEGEDEFTKAGKGIKEGKGRFFFLAMFLNFLRPVFKFLGITLMPKDATEFFTRFIDKALESRKHEKDGASGRSDFIQIMLDAEHEDHTEHGNRAVNEEQENGHKTETKKVLSYSDIQGQAFIFLLAGYDTVATVLSFTMFLICMNPDCLKKAQKEVDKVLEGKFPDYDSVQSLPYIEMCMNEAMRMYPPGYILDRICDKDIEIQGIKIPAGMNVSVPVCAIHHDADLWPEPEKFDPERFTPENKAGRHPYAFLPFGQGPRNCIGMRLALLEVKVALAAMLQTLTPVPCEKTVYPFTKDRFQIKAVEGLWIKFESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX40</accession>
    <name>A0ABM0ZX40_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936317.1">
        <property type="nucleotide sequence ID" value="XM_013080863.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847480"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049407">
        <property type="entry name" value="Usp38-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF908">
        <property type="entry name" value="DEUBIQUITINATING APOPTOTIC INHIBITOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21246">
        <property type="entry name" value="Usp38-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="488"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="829"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012936317.1"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120459" checksum="586F9FE4E6ADE45A" modified="2025-10-08" version="1">MSTWLKRNTSKKYVLPQEQESMDRILEGLLESQQPEQVKSAIIARICEQGAQPTHPPATVRGVFLVSYKWILHGSTNLEVASGFKLLQQWGCHHLTQFTAFFTTHLVSQTLVPGQANDANVPLLIREGFRVMNTAGAHMFHEHAQAVQSGVTRFVRGAGERVAVRNLTLLLSEFPECMPTSEAEVSAFCLDIVRHLSVGVPPQDGKEILRFIRQTDEVSQYLSMVWRLHPATLLSDCLAEIFRVISTPRDDATAAALENSEPAICLASLVKHVPIELANRVVKEAVMDSQVSETSLATAVDQMVEWLKWPTAQNVDLWIARFLTELAAGRRFTLLVHITQANVEQVAENMAYPQLRSASFCILSQMLLSFQHSPEPFHKALDKIPGVLASLRVEEPLRRDHWLPKISQLLHCLMYQHSGFPDIYEPVLDLIKDQPVPSQEEMKTLLKQKQWSSQVSGSSADQLDSLSSVVSSSLVSTVHQEKLEVGKTGLENLGNTCYMNSVLQALYMCDRFRQGILSKPPTGSENLLVKLQHVFAMQSQSLRPCTAPRNFLLSSRPPWFTPGHQQDCSEFLKYLLDQLHEDEKTAASGCRTIAKSPSSNSLSSNGTLKLSNGKSSKKGEVTLTSVKLKSEDNSAGDLSLKSTMSLIEKTFRGQVQTTLKCLACKQESQRVERFADIPLAFPNSSKSSDVPQKILAGGSGTPAPATATTPENSSQSGAPPSSSSTSSEVDGAESDGPEGSFTLNDLLSFYLKPEKLVGDNQYHCNGCGKLQDGERRIHIVESPQYLILTLLRFSYDTKLQTRTKIFEDVQYPRTLALPVHEVTPPPSPSSSTSSKDSFSSSSSNSKKQHSRGNSSVTSNNVITNNNNYNNNNVDEHKPQSSSRLEQILKQLAPKTDDEETSVHHCDLYGLCAVVVHSGTSSECGHYYCYARHSSAQQTDLKVLEKVNVDLNTLDLLPDKWYNFNDSRVSHSSFTSFSNVTKKFSKDTAYVLIYHKLTADGQDQSLSSDPPLRSDLRDAVVKDNEKYLKEQELEARAKEEQQRRRSASVGSASLHKWRDDDDDPPGGPPGFGGAFGGGGGGFDSMGPHFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXI1</accession>
    <name>A0ABM0ZXI1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Kelch-like protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8" type="primary">LOC101846420</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095882.1">
        <property type="nucleotide sequence ID" value="XM_005095825.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095883.1">
        <property type="nucleotide sequence ID" value="XM_005095826.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936539.1">
        <property type="nucleotide sequence ID" value="XM_013081085.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936540.1">
        <property type="nucleotide sequence ID" value="XM_013081086.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846420"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005095882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005095883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012936539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012936540.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="66965" checksum="43702E55FA64CEC6" modified="2025-10-08" version="1">MESASSWLQQYYNAMSCGFERLYASGAHSDTTIIVGEKTFQCHRVVLCAISPYFDAMFSSGMRESVSGVVKIEGTESVVFEAILEYIYKGLDTVTDENAEAILKAACLLQMECLQKRCEEFICKTLSIANCFERWRLALWHCSQHLKQQAWKFIMSNFVKISQQDYFVSLEKDELISIIKEDDLNCPSEEFVIETVLKWVQHDLEARGQLLGDIFPYLRLPLTKPQFLIDILRKYAFVKEHTECHMYIDHAKNFQLLPAHRHDSSSPVTSYRTTSPFEDILVVISGGESPRPPYVRSKNVLAFGFNSRKWYRLAALPYDPGIEFATCVHSNDIFVTGGGLFKACFLRYRSKKDKWSQCRAKLKSGRRRHAMAACGNKIYVIGGYNSELEQGTKVQSSIEEFELGCSEWNEVGNLITPVSSISATATKDKILVFGGETNDRTDTPSIQCFDTQTHTTSIIAQLPLACKLTRATVCNNCTYIILYNGKIVQFDHRNDNVKVMGHIQNFDCVHYGLVHRRGCLLLLGGQRIIPGPTPVRALVDTMLLYDVRNQRVIMLNDRIPSPRLVDSCAKITIEKKFLVTEYVDPPPTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ01</accession>
    <name>A0ABM0ZZ01_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101847720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012937445.1">
        <property type="nucleotide sequence ID" value="XM_013081991.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847720"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="8">
        <location>
            <begin position="107"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="325"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012937445.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46311" checksum="6FDE6B76EE1D3A97" modified="2025-10-08" version="1">MEEAQKSEDELLGLGTLESDVLQIAGGEIKGVELVATDENLEDIEAELLLLSSPAPGQEKPKPGTSLKSALEVIDDDELEILDDSGSDVMETDDLSEDSNGFIDGKISIFCCQGCLFVWNAEDAQMLREECRVVGKLSGCLPRAPRQNNHLGLPLQLMPEEARLLVDIDAAVVVEEVETSSKVQKAREKAFKTVREENFKIQQQLYKECRKEEVQHRMSDIIAGKKAKKRKLQKEASEKESAGAGAEEEGSERTHPGQSNERTQAGGSDNVEENTEEDNLTADDIVNSETSIKHSLVQIFTENPWKRSLQPASSWNFPTTDKDILRYAVFKDLWKKGYYLTSGAKFGGDFLVYPGDPARFHSHYIAVCMEQHQEIPVLDVISMGRLASNVRKTTILCSITRRNKVVYTSLQWTGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ96</accession>
    <name>A0ABM0ZZ96_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011682</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937589.1">
        <property type="nucleotide sequence ID" value="XM_013082135.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011682"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012937589.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30385" checksum="43CAE70C12093156" modified="2025-10-08" version="1">MGQRKLGSGQLTMTSQRHLLKEKQLFRAHVELLQRLLHSDWHYLPSYKKNAIFLTSHVHPVVKVTSHNPAPSRCGQSSPFSLIHPPVFRPTTDKKLRKHHSAPRLELRPLSSVTPSPAPLRDTSSAHFSLNTPRSVHWHPVAIQKSTKSEQLLHSRSHGARYHCELLGPASCKLCTRSLTELHVPPGNTRSLTELHAPPGNARSLIELLVPPGNTRSLTELHVAPGDAATGPLGCPDGVASPWHKCPLCTAQEEQISRNTAMSQTAKPPVTSAVSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZC1</accession>
    <name>A0ABM0ZZC1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol dehydrogenase 7 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937637.1">
        <property type="nucleotide sequence ID" value="XM_013082183.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850716"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF50">
        <property type="entry name" value="GH26015P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937637.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37176" checksum="A9597274162D77F2" modified="2025-10-08" version="1">MKRRIPTGKMCASLLSFETILSVLVLLAALFVLQYIYRGFKISGFSDRYVLVTGCDTGFGYRTAKKLDGMGFNVFAACLTKEKMEELTAACSPRLTAVAMNVTDDSSIVEALSVVKSHLPKGQGLWALVNNAGIVGPPGITTWLTKADYEVTMKVNFYGLVMVTKTFLPLLRQGQGRVINTASTVGRFALPPCPYTMSKFCVEAFTDVLRRELRPLGVTVHTVEPGGYKTNITDYNLAMTAMEKSFNQAPEDVKQFYGHRYVEKLSKLASVLVYLVACPRLYEVVDTYIHAICARYPKTRYVVGLNGTFFFRPLWTMPTWLSDFLMGMGYPLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2T3</accession>
    <name>A0ABM1A2T3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101856551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_012939687.1">
        <property type="nucleotide sequence ID" value="XM_013084233.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856551"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012939687.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28613" checksum="1DBC9A568EAFCA99" modified="2025-10-08" version="1">MAEHDNFITKAIKGYDYVLENGDPRVDGWFLMSSPMPSFIICMAYFIFVLMSPTFMKNRKPVKMKPVLIFYNFSMVALSGYMFYEFLMAGWLTGYSLGCQPVDYSNSPKAKRMARVSWLFFMSKFIELLDTVFFIMRKKFNQVSFLHVFHHGILPVSWWFGVKLVPGGFGTFHSMINSWIHFMMYMYYGLSALGPAFQKYLWWKKYMTTLQLVSTCTPMCDIPIHNISIHNKQIHSIPIHTYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A332</accession>
    <name>A0ABM1A332_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101845704</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939847.1">
        <property type="nucleotide sequence ID" value="XM_013084393.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845704"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046883023" evidence="2">
        <location>
            <begin position="31"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939847.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30402" checksum="11450FB96F5AB105" modified="2025-10-08" version="1">MYPVTWSIFVRRTWISLGILLSVVLTAVHGACPGDVSTSAHSCFTSYSFHFENMRSSPEKLCCGVDVETLRAFCHSYVKAISCLSTLRRACPPDTHHLIDSVLVNLDGAQEGLHDLCADDSIIESYAMYQTCFRSTGYSSERCFQVHMNESNQHIKFLSNVNTKRKDKFCSGMRNVVECVQNTVRGRCGEGAAKLAAILVKPMVRQSTDCDYSVINAKQTTSRPSHGNPAYISDEHGGRQTEVQDGGNTGSDARAPFAYVILAASLVAMVLGSLQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A361</accession>
    <name>A0ABM1A361_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATPase protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17 18" type="primary">LOC101851960</name>
    </gene>
    <organism evidence="15 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101691.1">
        <property type="nucleotide sequence ID" value="XM_005101634.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101692.1">
        <property type="nucleotide sequence ID" value="XM_005101635.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939878.1">
        <property type="nucleotide sequence ID" value="XM_013084424.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851960"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="14">
        <location>
            <begin position="88"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005101691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005101692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012939878.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="15812" checksum="6383FC4859A6620D" modified="2025-10-08" version="1">MYACAKFAQPSARCLSVLTRSALRPLGSAVVVKQEPQAVSGASLATYSGISALNLTSKATSVSSLISQIRNFQTSAVQRDIDQAAKYIGAGAATVGVAGSGAGIGSVFGSLVIGYARNPSLKGQLFSFAILGFALSEAMGLFCLMMAFLLLFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4L9</accession>
    <name>A0ABM1A4L9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuroblastoma-amplified sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101864470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940751.1">
        <property type="nucleotide sequence ID" value="XM_013085297.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864470"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054751">
        <property type="entry name" value="NBAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029145">
        <property type="entry name" value="NBAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22913">
        <property type="entry name" value="NBAS_11th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15492">
        <property type="entry name" value="Nbas_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Neuroblastoma-amplified sequence N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Sec39" evidence="5">
        <location>
            <begin position="623"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="NBAS subunit of NRZ tethering complex C-terminal" evidence="7">
        <location>
            <begin position="1872"/>
            <end position="1996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012940751.1"/>
        </source>
    </evidence>
    <sequence length="2247" mass="253289" checksum="C05A59E075270C71" modified="2025-10-08" version="1">MSIIWFRSQRDGLENLYGKGSIPQEPYPQWRCVVWVDDETMVACSRSSGAVDVFDIVGSLLFTIPGTSGETATPDLSDAVAALIFTDFSPPDDKWSQELLIINHHGSMSSYFVDRDNGFLLRYTFALASQYPRGISSVSYCPRHKILLVGGSGVAEESSETAGARGEGITAWRLLSDTPFCKLITDYEEEKEKAKTKTSFLSLMRVTSIFQRRHAQVDGIYRLCLSPCGTTLVAVHFSGKLSLWQVPSLRLVREFLLEDQPDWDEISPDFIGNPSKSKRMKDLVPHKQLIDVNFWSETLLILARCTGAVSVVSPEELRNRLGKSPEWFEPSPQVTQAQNGGFLGLECEVRFPKKRIGLLTEGEEEEEEDSEDEDVSLVAQGTLMTKQVLFYLTDSERFQPPKKKPRYVTKLHRIVQLKSTTPEELYTRKIEAEEYGEALALAQAYNLDCDRVYQRQWRKADVSLASIQDYLSKISKRAWVLHECLERVPENIDAMKELMEYGLRGTDLPALIAVGNGEDGGRFILCDPDEGLYEEIYDEFDPESHRRREEKRKELRDALLEQVHFSNLNLEQKELCRARLKFLQYLDRLRTYECILGGEVAAADRYNASFYAAFRSRSIYEIVAEYAQDNDWRAVETLMTFHSADLAPHRLAILSNFPETADPGDYKSLLPEIGDDGEVVSWETDQWRDEDWAQDPACRKAVDLGSEDEAAFLYTDFDGKYRTENLTTSVVQEWYLERAVEIERRSRLVDLAIELVKLGIERDVENLSELLDELITMEMMVYDCGVDGSLTFARLKEMADYDRLELFMSQSSEEMCAKNLRRWTVPYLLRCEQREPGAYDRLLRDFILTRARNDLSSVLKIFEESKASVSAPVIRTATELMSLVLDTLYSCERDDQLHVATEIFKCLPAHHSDGSSESPESLRLHKQADQLEYHLSAAKIFEENNMKMTLAYIKSAENDPEESRSLMVKLTRLAGKRSLPLTEMEWHKLHDSVMLLQNKVFRCVSRNVCHEIFVESLMCSSRQDTIRLAGTMLERSCTETKASRSQRGTSLDKVTYSRAVELTLSAAREYFDSSANLNDPCMDLARSCLNLILDAPQPIQAELDLIASLALLEEFGVAILPLQVRLSTNRLELVKKAVSSKPTSYKQTQRLLRLGQLLGIEDKDNSEGMIGQLCAEAAVAALDYEFAYQCCERLINLCHSPAWSVCVKLAELEGFRNIDAKAKLLSFALTYCDRDMIPPVLQARCLLETQILYEQVNRAVNDTREGSSEYSESRESPFSARAAIQQTQEILSSTRRTTSAVLSTVTDGRWWQSAVTSLKQPARRTRGRAGGLSDKDDGNLAFRKQGCHPFYASIIEDCYEDVRSADYSCVWEDVEGEGGVGVGEDALSSNILRTAKLEEMLTQGATRQSAAEALLELAKQTMPRDAGLGIAYLLATPKEFPVDSCFDEFPSTDISLQLAVYYYALRVYSALQPFTPAHVYALYRQTPAKIIARVLDYVNSSDLDPEWPLEVGELVEKMKNYQGMLEDYNQACTLQRLGKGVDVIRFAEDSQYKRETIFGLAMSVEEEVFGIALSLAQRYDLPLWDVYMCHLEFLFSDSGLSIDALQTRVNKLDILSTLREQRSEFTERMMSRVYPTLAGDDLRSLAYFFGLLDGVQETLLCGLAASEHATLVKKLKSVCPAIDYKRLMDADTPPVDVLQPCLTAANINSLAKLASQIPDKRGGVLHPSSLYSKWAGRVFWADADGKPLPDTMAAWVHRYEAIGEWIQKLRPEDLVSLIDSLVFTVQGRKTLDVPTRDEITKRALKFSRQSGSGKKKKQEDTGVMTWEECGLELNSRLSHLKSLTNDTVQSFAQAEDPVFSSYAERYDLSKGNQEEVELLLVQMILDGQAVELVDDILQIAPPSSLRTRTIVQQAVNHIAAALRGEKVTSEVTVRTSWLEVLQLVVENVREHQDNGGDLVQAEDVMSLLRSFCSDAAIEVPPRLDVLRVLEKSFDLSETDRVLLTLYRTDALVSSTWPDINMSEDKIISEEARLELFSTILAKCDNRRFFVSLSKILILWPAFSCPFSSTEEVPWVRVFSAIVERLGEEAGQVINYIVGKECSEFPLNGQCAGEMFELLLKSRQTVEGVKLALRSPDKQLTERALQALDTQSQGVDDCELLQLILHKNLAARVVTMPVYSPLVQHILQSQGDSDVPEVATPTQVARQLSEAGHRAEAGSLLLQARSSHSALQTFSSALASVGYWLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5V5</accession>
    <name>A0ABM1A5V5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Platelet binding protein GspB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941418.1">
        <property type="nucleotide sequence ID" value="XM_013085964.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852201"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="910"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="958"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941418.1"/>
        </source>
    </evidence>
    <sequence length="1200" mass="123910" checksum="4F33F9D9F471AD4D" modified="2025-10-08" version="1">MAAVKEYSGDPALEEEDIRGDGKKKKFKPLSAVRKLFGKKRKKEESVVAVKAQSTTALHSEYVEEEDDDGGFKTHQKPLSLSGTRSISEDSVFSPEAREANISVFPKSAVSEESLPKSAFQSELFSKLSKRRSQYSDDDHDDGLPRSPVPPVTTADVIMGGSLKPTPSGKKSSNRDSDQSLISVDSSENEEEDLFTAKWKASVPSRKSNSESSLSQAKMDSLDFTGIEKTEVLKSSALKDRMSIKPKGRKATRQSRKKKESASPLSLPSLNEESPTRSRPEEIPSLKPSGSPVTKDAVKPTALKSDDKSQVSAFGQSPASSSGSTKAKVSSITVASSPATSPSTAAPPSSGLSSSPPKGVTAASSNSSTKLSGSQRFSGVYSPTSAGASGPGQTPQASSQTTANSSSSSSSSNNIPSVSLSEKKSDVSSASDRGAEVTSGRPPVGTSGQKQQQQQDDAKCAVDIKARMSNFQAFGGSSKSSASESPSLKVSDTNSNVTLSPKEDYKLKRQNRSKTLPGTTEDQQQASPRVQRASSHRVQGSPAKIEISQKEPVVTISENSTTSAASIVSTSTASATSGLKTSTSSSVRKLDSSRYSSVDSGSSASSEPSWISMVRKKKEESEAEVEDAKNKTVDSVKQDSAKAAASSAAKAGGNASTPKSVFSSSSYLEKKRGSVDTTSVKAKEANEQSVKKTDNPSYDGSAKRPSVDAGSTKRPSIDIGSTRRESIEINISELSSVKALSSTFGSSSRGENTNRVGSQKDNTNTAGSTSDKAKMFSSSAGSISGNNWSSSVSEDNEKKASESSGVKPSGVGHFRGGSVKTSPTKSIEGRSAFPNRGGSVKVSSTFSQLSEPPRTGGANTSASSTSKLEQKTDTSGTTSSSSSASSSAPHSSQHATQSNSSTSYHAQAVTSSSSSSSSSATTPASTSSSKSGLGTSTGTKTQTNTASNSAKPPSGVQTSASSSSTSANPPSSSQFGVKSSFASSSPSVKPVNFSGVKSLSSSSSPASGNVPSSASVSSSSNPVAASVSSSVTPSKSSSSSSSSSSTTPSARASSVRSHSSFVSSPASRPQLSTTSPSLSSRSSGITKSPSMKATSTGAPEKQEEKTTNTAKVPAWRANLQKKNEMKIEIIENSSSSSSSSSQSKSENLKKNNDNSRVAETAKKTDSPATGSALLQSDKASNRSSKVLDMVKNFQNLQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6T8</accession>
    <name>A0ABM1A6T8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-1,4-N-acetylgalactosaminyltransferase bre-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101848307</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941952.1">
        <property type="nucleotide sequence ID" value="XM_013086498.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848307"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="11">
        <location>
            <begin position="67"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012941952.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23784" checksum="A384282318A1BE39" modified="2025-10-08" version="1">MLRRQQLDYGIYVVDQALPGRFNRAMLMNIGYTEAMKRYNYQCAVFHDVDLIPENDRNIYSCPEQPRHLSAAIDKFKYRLPYVKIFGGASALKKEHFELINGFSNRYFGWGGEDDDMSERITSKGLTISRYPMEIARYKMIKHVGEKHNEQNPERFTLLRNVKQRMSKDGLTTLKYHLQQVDEMPTHTRLQVLINEAEVRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7E0</accession>
    <name>A0ABM1A7E0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitogen-activated protein kinase-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101857668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942281.1">
        <property type="nucleotide sequence ID" value="XM_013086827.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857668"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055292">
        <property type="entry name" value="MABP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012942281.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14304" checksum="2AD18D85AB1EB794" modified="2025-10-08" version="1">MDSVRPQRKVLRSPSVKRKSKVLPVNQRVHLERVLGVTVSSNAGLSCDSNNGTIAYPAGCVVVLFNPRRNKQSHIFNASKKTITALAISSDGKLLATGETGHQPAVRVWDVVEKTQLAEFRGHKFGINCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7I5</accession>
    <name>A0ABM1A7I5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Endoribonuclease Dicer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC101848232</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942349.1">
        <property type="nucleotide sequence ID" value="XM_013086895.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848232"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15903">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10843">
        <property type="entry name" value="DSRM_DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044441">
        <property type="entry name" value="DICER_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048513">
        <property type="entry name" value="Dicer_PBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048512">
        <property type="entry name" value="Dicer_platform"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20932">
        <property type="entry name" value="Dicer_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20930">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20931">
        <property type="entry name" value="Dicer_platform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="456"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="22">
        <location>
            <begin position="676"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="20">
        <location>
            <begin position="944"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="19">
        <location>
            <begin position="1955"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="19">
        <location>
            <begin position="2237"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="18">
        <location>
            <begin position="2431"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="402"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1146"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1640"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1735"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1816"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2177"/>
            <end position="2202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1148"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1172"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1183"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1204"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1232"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1641"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1753"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1776"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1789"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1830"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2179"/>
            <end position="2196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_012942349.1"/>
        </source>
    </evidence>
    <sequence length="2503" mass="278222" checksum="A989EF6B7B3CAF2A" modified="2025-10-08" version="1">MQASNEARKGSRYHRLDDIPTNTFTPRTYQIQLLDSALRRNTILCLGCASSKAFLALMVAKELASFTRIPLTSGGKRTIYLTDSEDEVINLCQTLPNHTDLVVGQSPRCDVDLSESNNQTCQAAADLWREAMEINSILVCHGPVFRDALRHAFVKPTDVHLLIFDDCHRSVEVDNHCYADIVSEVKILPDEVQPHILGLTASIAGTECSNPGKLKETVHRMENTMNAYAETSMLILSERYGCRPKESIVKCKGEDDESQVLLQELLEDILEEHYIFFTNCRIAVDEQTDHRNPTEIPIQVLSECLNILNILGSWCTSSIAEYFVMQLDKIIKCEKNDIHKKFLRCVTTTLRLLTRKFEMNFHPDYDVDELLEYTTPKVQELVKVLRHYKPEVDFIIISNDEESENGDDFSDMSDDDDADSNLSGSEDADENSESQNKSSLSSKPMHIAVKRTADGGHERIVTYSEEEEKNLCGIVFVENRFIAFGLNKVIEEVCSWDENLCFVKSCHITGQGLRNGSGKMKGNKSYKRQEEALRKFRTQECNLVIATQELEEGIDIPKCNLVVRFDPPCDYKSYALSKGRARARDAMYVILLNQENFETFNANVGIFKEIEQVLLGDKRVSGTKKSMPELVYREDYGHDGDTDDEEDDVIEDEDLLLPYRTLPGLQNSPQVTLQGAIALINRYCAKLPSDAFTHLTPQCRVEKQAGDTPVFVAFLRLPINSLVKEELKGPPMKSKKLAKMAVALKMCEILHGKGELDENLVPVGKEMFSYEEEEEWVEEEDPAGQARPGTTKRKQYYVKKVADALAQCRPVEGEPCYLYLLNLRLTGPITDEQNTRGRVIYAPEDTTQTLGLLLSKKIPQMPSFPVYTRSGEVTSSVDMLTSDLILSEEEISQLLKFHHFVFSDVLHLIKDPMEFDPLKADFGCIIVPLNGSQDLTIEWSFVEKVIHFMQMEKKGSFNKQKKKESFTFDVEDFKDAVVMPSYRNIDQPQHFYVAEIRQDLNPLSSFPSPELYKTFQDYYSTKYGLVITNTEQPLLDVDHTSARLNLLTPRYMNQKGVALPTSSAETKRARRENLQQKQILVPELCDVHVFPASLWRKTVCLPAILYRTNSLLLAEELRRKIARETGVGVENLPLGFQFPQLDFGFETNPEKLKGPDSNDGEKNDESCVDQKVSVDGDSKEAGDDTYVETPPDDAAEVTSGSENEDVKGAVESGHDESDLGRDVKNVKEKVDSSASSDSDSGIVSSGSDSNIVSLDHGSQTLESEANHKSLNMINKEKSSLCVETAEKKLSDISCNEIKNVKREEIVNQDVKSNCIPVASRYINSAQCNIYSPEGKQPTVCCSSVDVKTEGSTNSCNNFDSTSSVINEYTTLSTLPHSQSNHQNSTSSSKCHSSIECPPDLGELPGHIASNEPCFISQNVPGSIGAIIDATNTSLPCSSPSLSSVSLPVTSSNLLSKTSQNSTNDSTTVVKMVSPVPVDEDRESSHVALSLPAEIAEGGDPDLPNCNHQSDHKVHLRNHKVQAGQSSKEHVNTEGKPLAAVPCPSSSQALLGCETSDCVVSALPSTSLVAADAQSALASADHGELCPPGINRCDMVHASSPHHSCLLHSDDKDHPSQPHHAGLLSEEVTDCHVLLGEKNAENNHPSQADASITTVPSSTQDHIPAAKIERKAQGTSQDGAGVLAGDGNLKSTGVPLSPRVHEADPAIVMNTLGQELSDLDIDLVCPQASTSETFQEQPCGWASAEWKEPPSKQGCHQGSQPDAKARQTQKNLEEDEKYSRKNEKDFSSVDPATQSDDVLGSQANDSDVIKFSFDAKAPSSKDTDYKMFSPHSHQGSNDKGNSHSSESSPPNTKTLDETNKGTNCSAFKLTASKVGAGTNGVKEFHIGVWNSNKNSKVLASKDKHNEAQPLREDCLLPPRKPSVWIPVANYCANGLLSVSLDADRDLKTFVGPSPCLILQALTMSNANDFFSLERLETIGDSFLKYAITVYLYCSYPGIHEGTLSYLRSKQVCNYNLYRLGRKKHVAEGMVSTKFEPYENWLPPAFVINEDRRRGPVPKVVIVTPGLKQNNSVRNCCVDEASCAGGKVSGSARPDETAQFEKELQWIEQSQEAEQREDLEGAGPAVLTPYSLQRHHGLPDKSVADCVEALIGCYLTTCGRKAALMFMSWLGLKVLPKKKRGSSEKGDADLKKSGEGRQGKTSWQQISEQEFDELRCPPSPMFSRSPENMVQLNHLLEGFEELEEKICYKFQDRSYLLQAFTHASYHYNTITDCYQRVEFLGDAILDYVITRHLYEDSQKYSPGILTDLRSALVNNNIFAALAVKWGFHKYFKAISPSLFSVIDKFVKRQKEKNEDDIDIDEEFRQLEDGEVEEGAEEEEDEEEVEMEIPKALGDIFESVAGAIYLDSGMSLDAVWRVYYRMMKPHIDKYLKSIPKSPVRELLETEPETAKFERPERTLNGRVRVTVNVVGKGVFSGVGRNYRIAKSAAAKKALRSIRTMTQNLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A846</accession>
    <name>A0ABM1A846_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase DDB_G0268948 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942650.1">
        <property type="nucleotide sequence ID" value="XM_013087196.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847210"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="57"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012942650.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30485" checksum="65C5DDC7A4A5B910" modified="2025-10-08" version="1">MSSTSTSGSTPGKSSNPYDVEEIINHYREHRPTYAQEVFETIQAFCEENKAEFDLALDIACGSGQATVPLAGIYKQAIGVDASASHVAKAPRHLSNITYKVADCNFPLNFIESGTVDLVSVASAVHWLDLNNFYAETDRMLKPGGVMAVFCGGFPSYEDQEVLSIYKKILATTGETHPEQMKVANDNMESFRLPYPNSKRFLPINRHLEATAEQSIQMSLTIHSFQDYVQKHPEYMEEVRQMFREWNKGDESKTYKFAVPTYLLTSQKPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A987</accession>
    <name>A0ABM1A987_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943246.2">
        <property type="nucleotide sequence ID" value="XM_013087792.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846767"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08253">
        <property type="entry name" value="zeta_crystallin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="13"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943246.2"/>
        </source>
    </evidence>
    <sequence length="285" mass="30484" checksum="C1FEACFCD0C566F9" modified="2025-10-08" version="1">MSTMRAIQVSQFGGPEQLKLETVSVPVPKEGEVLIRVMAVGVNPFETHVRAGEFGPRNMPFTPGSDAAGFVEKVGTGVTEFKAGDRVYTTGTLSGSYAEFAIAIPQYMSHLSDRLSYAQGASIGIPYHTAYKALHLRAQAKPGETVLIHGGSGAVGIASIQAAKAFGLRVIATAGTKGGQDLVRQHGADAVFCHRGKGYMDKIKEYTENKGVDIILEMLADVNLHNDLDLLAVRARVVIIGCRGNIEINPRLTMLKETSIIGMGLMTGSDVSMLRVRKRGGREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9D2</accession>
    <name>A0ABM1A9D2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943330.1">
        <property type="nucleotide sequence ID" value="XM_013087876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013091"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943330.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16577" checksum="41239A91479C899D" modified="2025-10-08" version="1">MDDKTFGHSIAITVYLANIYGFYGETNLDRLSLDEVNHAANDLFRLAWAAIQTSDNDEKKQMVDSLADKVPSYLQYFEDTLEASNTDFFLGSNITVSDICVYDILWRLQVRGLASVENFPKVDYLMSLVEQRLANVNFKRGEPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAP4</accession>
    <name>A0ABM1AAP4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monocarboxylate transporter 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944085.1">
        <property type="nucleotide sequence ID" value="XM_013088631.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851300"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF251">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944085.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="63828" checksum="02FCC13E78D6E7E3" modified="2025-10-08" version="1">MPPAGKDRDGSEVRTPLQSDNGHLKVPGSQNGVSRSRPQAASSEPPRQVQPDGGWGWVVCLTSLACNGTVFGIINTFGILYVVMREEYGKDDPNVSFKTAWVGSVATGITFLMCMISSIVSDRVGIRPTAVVGGVLAFAGMMSSAFVEELMLLYLTYGVLLGFGFAFAYAPSLVILGHYFKKRMGLVNGIVTFGSSVFTIGFSLGLPRLLDQVGLRYTLVFLAGMIVLLVPYALTWKPVFTRENLGVSQAAMSTLSVEMIQSQCADCCRFTRKYLNVKIWRNKGYVVWALSNGISLFGYFVPFVHLVKHVQDEFPDDDGNILVMCLAITSGVSRIVFGKVADFQWVNRIRMQQLAFFVLGVCTLCIPFSASFGGLIAITLIMGICDGLFICLLGPIAFDIVGERGASQALGFLFGIFSIPMTAGPPIAGLLYDHLGSYDIAFHVAGCPPILGALLMFFIPKTKANVPAVTSIQEFAAVSCHDIYHSKLEFEAEIEPPKVSAVTPEVITIDDVSDLAQLTGVTSLDTDEDLSRSTLPADGAASPVDTPSSEIRETAIVEEAGAAYSDRDIVAENGKETDPMVPPAKVYSGDIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABK0</accession>
    <name>A0ABM1ABK0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013415</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944555.1">
        <property type="nucleotide sequence ID" value="XM_013089101.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013415"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045507583" evidence="1">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944555.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16146" checksum="5CEBCBBC40C19561" modified="2025-10-08" version="1">MMSSHAFLLSLVAAAALCLLLPGVISVPLSGGEEEIVTVQLVHHSYLGDRSKRSAESDMPDDMTVRFDLKGDNVELRMKRSSLLPAVTLSGLQLDGDIRGAAVYTDATRGSSMVVKRSVDNYKLTGSFVHNGKDWNLEPLHRHRRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACQ5</accession>
    <name>A0ABM1ACQ5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101851087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945187.1">
        <property type="nucleotide sequence ID" value="XM_013089733.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851087"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012945187.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14050" checksum="C5A7328B615DB841" modified="2025-10-08" version="1">MANAWQAYVDHMLSSGIQMGGIYGQDGNVWAASPLMKATPQEVAAIVSGLRSQSFEQGVHIGGQKYTVIRFQSDSVTAKCRTAPQEDQKYLLHACLGKTCVLIGGICGPAERDCTKKVEDLRDYLAGNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD38</accession>
    <name>A0ABM1AD38_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101861170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945407.1">
        <property type="nucleotide sequence ID" value="XM_013089953.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861170"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945407.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21689" checksum="3C53460367792251" modified="2025-10-08" version="1">MSDTTDSPSGQPEAVEECAPNAGATPLPVEGEEQTIQETEESTDRTTEREETGETEAPPSSELPPPGHTAPHPDPPVTAESKDSDQPQEISPSGGGNYDNAGYRPAGPETSGQQNVPLTINQLAIVASAQNKLPVSKVKGIVLRVGRHTESSLQKSGKWYKNENYVDKNTYSWKNMPLFEEYQRHLWTPAGTVRDSYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE21</accession>
    <name>A0ABM1AE21_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Islet cell autoantigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945914.1">
        <property type="nucleotide sequence ID" value="XM_013090460.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848865"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024114">
        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006723">
        <property type="entry name" value="Islet_autoAg_Ica1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164:SF4">
        <property type="entry name" value="GH23156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04629">
        <property type="entry name" value="ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="2">
        <location>
            <begin position="51"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945914.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44174" checksum="9CB654E9A41E683F" modified="2025-10-08" version="1">MSTYGYSGSNYDRFVENTNTSTLHKMKETYWTTKQAVIKKLGKKEDEHVVASDAQLDAKLEVFKAIQKSSMDLLRVIEKYQDRLCVVSQEENTMGRLLKAHSNKDKTRAGKMMAAVGKSESNSAQERLALHNPLRRLYQEVETFRYRAVSDTLVTINRMESARTEYRGALLWMKNVSEELDPDMYKQLEKFRKVQSQVRKTKSRFDKLKLDVMQKVDLLAASRCNMFSHVLANYQTMLLHYWEKTSRTMSAVAESFKGYQYYEFNMLRELTETSKKLAQETSSPERAEKDTDDYDDSLISVEEDEGARDARESKAFDESLLSGLRLDGTQKQNGTKPAGDSDFGPFTDFTSDDTLMKDDDDDFDFTGKILEAAAKNKEVQKPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPU2</accession>
    <name>A0ABM1VPU2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101852676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824434.1">
        <property type="nucleotide sequence ID" value="XM_035968541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852676"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824434.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="33355" checksum="5254672647333A19" modified="2025-10-08" version="1">MTQYNSSTDSARGWLAAAEHAGGPRIVAMDKRQTQHQEAYYLFFVASLGMALNLLVMAMIFVRRPLRRMTSAFLAHAAFLNLIKAAFCIPFGLNLLSGADGTDENQPQDCNLQVSLVLVYQAFCFIAWTQALVEPIILIFFDRNINLLSRFMYCDREGYTASQIAYLMSQARREDAATSAHGGSIEMVMGDAAGGAPGDAGVNAMPLLNLSRDSGETHAFAPLGACRHCSPAHSSPGETTPLRPSSRSRSHGSPQTSSTTELRAAGAHLDPLTFGDNSFEMEFTPLRVACDPIAHKEEELGEEDVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ13</accession>
    <name>A0ABM1VQ13_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protocadherin alpha-11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC118477143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824505.1">
        <property type="nucleotide sequence ID" value="XM_035968612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477143"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035824505.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17685" checksum="E8E3CD1E0B7F239C" modified="2025-10-08" version="1">MTLDITVTDVNDHDPEWTQFIPAVSVRENEKVGTSVVDLRATDMDEGLNGEIEYSIALGTNGTSLFDVKKFDDRAELRVAMSLIGSSGSQLVTVVATDKGSPRRSASVDVMVTVVDMNLHRPVFIHPDESVYNVTSRFLPKVTVPEVTVQVYWSLEITPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ18</accession>
    <name>A0ABM1VQ18_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Melanoma-associated antigen E1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824510.1">
        <property type="nucleotide sequence ID" value="XM_035968617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851716"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824510.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="27887" checksum="3ECC74B2C6E023C2" modified="2025-10-08" version="1">MKLGFTSNSYPSEDPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPSTTEGPYYTSDSPYTSDSPYTSDSPYTSDSPYTSDSPYYTSDSPYTSDSPYTSDSPYTSDSPYYTSDSPYTSDSPYYISDSTYTTGSPYYTSDSPYTSDSPYTSGSPYYTSDSPYTSGSPYNTEYPFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ84</accession>
    <name>A0ABM1VQ84_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101854484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101854484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824576.1">
        <property type="nucleotide sequence ID" value="XM_035968683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854484"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1712"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1749"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1772"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1816"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1857"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1906"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1931"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="1546"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="1712"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="744"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1451"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1979"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="656"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1456"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1981"/>
            <end position="1999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035824576.1"/>
        </source>
    </evidence>
    <sequence length="2028" mass="223571" checksum="742D2BBA6D489C99" modified="2025-10-08" version="1">MDVSVSNDLTLKQRQELSRLRDKGWRGYYKNWKLAVVPETQLAPSDSPATTHRHMGNAGRPAQAHGTTTARTQGGWTLAERPSSDFQSPERRVCVRLQAMETSWPHARRSCLADKGFLVKTDVQMNVGGVRLDHYIKGHGIGSVWTGMHTNYGSLVWDGLKPKLVKAYTGESRLYGVRKRGWKLDLGQLVEEEEEGEEGEDNSEEEDACAVLVLGGTSESGEIGSEEPLSRRHKRSPVQVPPSSSVSSTGPSGQSGHRVDNEDMPLNREPTREMRMESLQNFLSNQGFQEKYVESIGDSNNQQVEVKSQGHIIQSGVTTVSTTTTDQSQLEDDDYHQVTKRSVRPPVSTTSVPTSPSTTRPPVTSPPTSLPRHADASATLGDRRTSLVTSSTARPETTTGIDDLLGQLLHASLAASGPDPTMPGGGTGGIGGGEKGGGLISGGNRVIGGSNKPFAASQARTVQTADYLRSLLDHATVTIAPATSVTPAGAEVTPTQPPADANDILAQLLASGVQQQDTTETPRTIFSANPRARSFFHGLRNGSVTNENSIDKTSRGPVGNSDTTTTTTSTISAGTTATEASNTASLSRSTGPTVWASSTNRLSHRPQENANSIMVRGRGKNAHAKKSEVSFDNTTLDMSRESSSSSADTSAEKNSNETSSDGNSTMPGGLFNSSVTTEDPLDNSQEVTDPLASGESTTSSPLDSVDPISSLLGGNSSLDAGSQEETGSTTTIANLLESVDLDIYGPVKNDSSPAYGGLGVSNNTRSTEDSAEMMDRSNVTDSTENAVDDENLDIRDMLTSSRSRHLNNSDSHQVTSHEQPEGEDSWGQNSQESGLDLGDDGIMWAGLGDPEMTNTMSLEQCQEGHSSVCMTEAVEELTLVGHCDRKWLGHRLLDRCYRAISTPMSELGARQTCLRYGGTLAAADTDFFGNVTDLVLMQTATERRGFARRIWIDTTLNLHVPVDHQCSALQAGRIQRLPCTRRMPFFCQKEAHVPGEFFEDISEEEHTGIFVKNMTSFHPRTLWCPLRMSSFDDIIVWYKDGRPIREREEDEDTAFTNTNNPLPNRLDVDLSILERTGSGDVRIPKPAMLQGEYWCQVWRREPFRRVVSHKILVKFTDVITVHGSIITAPTDPEAAAMFNLMGHLSGLLTVLDHDLATISKSLTHKLRAHMPIVLDVISFVRRTNSQTGQTEFVTYICTATGDLPARMRGDLVDLYVSTLYNVLKAREPELRQSWNLRLPLDEAVNISMADMCPQSRLTDPSTGLTATFPSSVVNKMALSTDSCHGMFVGTAVCKGDFRSGAFWTRVRVTGRCDVRDQMTSDGEDRDDDSREDSGELKIGDVFDVGDGFVLGKLPNPALLELDEVEVEDDNVEEVTQRLAEILDLSDDLSDSDIETVAEVVDRIVAVNRPPVEVSRQLVRTVDRVLSAPEEELRRAEERSAAPSRSLVSSLYPLHRQPNNGPQSQPHSSERDSELTSQRRLLCFKTLIADLEKFGEKAQMTARDPHVRFVTPNVAMDLWDLDDPQHVVIGMGATHTPSWSEPLSEPRILEIKDKQWAEENLPRFDVAIQLPESLVRNSIRYSDESLRLTMFIFRKSDLFVPPQDRDTKRERAVVNSAVISASLGGRKIRGLEEKVRLVFKPFKDMPGREERTRCVFWDNTRAGHARWSGEGCEYNGTLHGRDVCLCEHLTNFAILLDFYGDDRPISAEHSTSLTVLTLVGISLSIFGLSVTVITFLAFKKLRAGRAQQTLFNMAIALLCFQCTFVMGVRQVAVWQLCLAVSVLLHYFCLVSFAWMLIEAVLQYLTFVKVLGTYIPRYTLKTVLPAWGIPILPVAAVLVTDYELYLGRREYCWMDVKPFYYAFALPVGIIMVFNLVMFAVILLSLVTRPKGLRSNHGNHKARETNIKAAFTIFILLGLTWLFGYLAVEDARIPFQYAFTVLTSLQGFLIFVLMVVRRKQVRDHWQAMCCFKSSDKKGKQHKLSAQSSNYTSSNQSVSSSRATPSYINHTYNGDAMVLQPPNLRRQTSITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ86</accession>
    <name>A0ABM1VQ86_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477373</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824578.1">
        <property type="nucleotide sequence ID" value="XM_035968685.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477373"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035824578.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12927" checksum="2A9F08519308E727" modified="2025-10-08" version="1">MWKCRKQKNHFLQISRIRSKDISCDAHQKRKVSGTGFSCYKTISAENSKYKEISPSVSVITGLDEASNYYYGIGNTGRTYVISYDNTVTWYTIPDDEYYNAISSNTFLSATFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQF4</accession>
    <name>A0ABM1VQF4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ADP-ribosylation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101860729</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824646.1">
        <property type="nucleotide sequence ID" value="XM_035968753.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860729"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824646.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41483" checksum="5F777493D9774130" modified="2025-10-08" version="1">MGSFVSIFKKMLGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVGEAREELSRMLNEDELRDAKVLVFANKQDLPNAMNAAEVTDKLGLHNLRSRVWYIQATCATSGDGLYEGLDWLSNNLRKNELIKMGNMFASLFKGLFGRSEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVIDSNDRERVGEAREELMRMLNEDELRDAILLVFANKQDLPNAMNAAEITDKLGLHSLRSRQWFIQATCATSGDGLYEGLDWLSNTLKKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR11</accession>
    <name>A0ABM1VR11_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Opioid-binding protein/cell adhesion molecule homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824853.1">
        <property type="nucleotide sequence ID" value="XM_035968960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850858"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046883162" evidence="6">
        <location>
            <begin position="27"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="234"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035824853.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52218" checksum="F35574DB754BF0FC" modified="2025-10-08" version="1">MDFDMKLVCVEISVLVFLCLLDISQLMTLEPSFDSPMANVTVKEMATAILPCSVKFLGRHEVVWTDQWSTLLTYEDRRIIDDERLSVERPFTKDWNLHIRNVKYKDQGLYNCQINTNPVKIKTVNLKVQVPAKILNNQSNEILVAREGDTITLMCNVSGIPMPTVTWFRLTTNEKGEEKKSEFCPGTNKVGISGEVLIIHNISRHCGDTYECNAFNGVPPPVNKLMKVSVEFPPEIELPNKRMGQDIGKETILECIITANPQAIGIWRKDGTEMKTLSGKFRVELYREEEYSVTLSLRIMYIEQEDYGHYTCEASNKLGMDSGSMELYDYSDYRRPRTTTPPPTRAPLPRTTPYPPRHNPYQQPHNTYVFTPRPNLEKGDRVRFEHNRPKYRPNHRPAAIDQQPEDGRSVSSNTESGASALDPAQWLRVLLLATVPVVLSRNVFIPGYCHILHCNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSI4</accession>
    <name>A0ABM1VSI4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477594</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825376.1">
        <property type="nucleotide sequence ID" value="XM_035969483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477594"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035825376.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="62958" checksum="BAF397419D969B54" modified="2025-10-08" version="1">MGMTNMPKFNADAIWTIEPNTLCNKSKVFQLLGNLTERRLRQGDMLNCSEMTTGLAQLKEVSEGCSWEIKSVVSILMGTAKMNYFSACTPGSCNVKYAQMCLDHAEETMPDNFRSLNNADRRMACQNLKHSLACVTNHTRSCSGDIYSSVSRRFESIKARFMNNNCTAFFPRPTDCKPRSGPQPRPQPVNDIQQLKKKATESFFSSRISRERCRKYATNFTGIALFNGTRSNVTLYRRTVASLECDFEAPSARALPLLCLTGNCSGENCTSADLKQCLPGQVCGFLCRSDSKGKCLNYIERGCQNVSYCDKPKRTGQVRGCCVSNLCECSCSPSAFRATTKAIIENADPAKCKSTIDQDAALNPIRQCSLAERRSLESIAPSCVKTKLHEIGLAYTNEEVCTQRKCPSQTELKNMCLPVTGFSCTRDILECLAFNSLGCQDRERVVFYLLTGDQLEECDANLINSVFPAFQSTPSLKPTASQCLLRMFNKSEPICEALNETRYCIAEHINDLYAPRVVSFLDHLILAIDCSALSDNCQVTSKFGPTLFMTLAQLFQRNQFDVAPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUM3</accession>
    <name>A0ABM1VUM3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101846143 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826115.1">
        <property type="nucleotide sequence ID" value="XM_035970222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846143"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF13">
        <property type="entry name" value="BASIC IMMUNOGLOBULIN-LIKE VARIABLE MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="676"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="912"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1333"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1441"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="699"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="923"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826115.1"/>
        </source>
    </evidence>
    <sequence length="1488" mass="163070" checksum="729E61CD754CFF6F" modified="2025-10-08" version="1">MGNKLHTTKPYIVDEYLSEDSDSDDDWLSAPEWSSRRTSAANQSGESDDDSDKSKDGKSKKDEPPSRQVSVDSRVVSSLVSEVELLLSYLDKNDYEGAQRAARNLKECGGGGGGGVSRGQIEEELSPLLPAAKISSPKRLLAQERNHNMDNGNGEESQPLLTTDETMNRDLGASDGPSIEEQRQALAQLDDELNAFEEMEVQVSQGLPTSPTATAPPAPRRRSSSGSGIPRLVRSSSSCSEDSDSGMTDRRSGMRNHRRSPSPGNAGQTSGIPRFGGSRPLARMVPKLAEADGNSSQTKSGLNNAMSDSNYRGRRSPSPGNRQLQMKANISPKTSSTPPAARLGQGAGLDAEISGLDDSKDPETAAWEVNISDFTGRAKKNKKRSGIPSVWTKSVGKEVSSVQSRGDISPSSSSSQLSMVQASQTFTVLSASQSESIEAIGECRDPTLRKVLDLRRWHCMSRPQYKTSCGISSVVSCWNFLFSTMGQGSLKPLTQEVAMKILGFHSPFEEIKFGPFTGNLTLMRWFRRLNSHFGVTGRCYYMFKPRGRNKTVGVTSEMALEKLKEGLKDPNTTFVYHCHNHYFCPIGYEETPVFCVDAYSGFLNPEAIESWILIGETSRKYPAIHCKLWDEISTDLHCESPNFINIRQSWKGVMQRNTSKKPGGNLHCIMTFQRSTGISTSPSQNKSSIPRSSRLPVRPGSSSSLDGGSLSPVDGEGGRPAWRDLDSFYEEEQGDYVETLDSEVSDDEVSMWGTWNSGVGIRGRGVDRRRETKGQSADRSKGVKEVCEDCNEEIQEPAVESKRKMFGQSVDSRGKIVGQTVDSRGKTSGQAVDSRRKLWGQTADSKGKTVEPALNKKITDSKGRTWGQTLLSKGRTLGQAMVNKGKELEQAVQSKGKLIGQATERKAKVWGRYRESKVEAKEQTANSKVGTKGQTVNSKGGIKGQSGNAKLPRGEESIPKNIPSKENLKETDMDNGANSKEETIEQEADGNTKGKEEKKELAVDIQKDERAEIVNSRVKIWIQDVDSQVEIEEPTVDSQVEVKFEEPNSRIETGEQIVSQEVEIREPAVEYQIEIEKSPVNSHIEVTELALINKVEVAEPILTPEIKIRESVMCSQEEKREPAVNSQIPIRILAVDSHEERKEPTVYRQVEVKQPSVYSQIEVREEVREPTVTQEVKIREPALCSPTEIREQAVKSQIPIRIPTLDSQAQIGESVISSPLEIAEHTADSPMAAKNHLTGNSHIEIRENISDGEVAVDSHVEIKEDADEGTSPDKSVRKHIEFWEQMEGKKSAPSSSADLQRGISDRTDVEMAEEGKGIDIDKSNVEDVGEERGVGHLVGDIEDEDCDSDGTANGEESESFVSEREVTGDLSAVVGPDDDLDVVKGVDDVADEKKDSEDEGCDAVVVRGEIDENVGRFENYSNEDTVSVEVGKAHNMGFTVGEDGNVLTEEGEKSDVPVCDEGVYGDVGEATSDRLGATETAGETIEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUS7</accession>
    <name>A0ABM1VUS7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 6-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101855499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826169.1">
        <property type="nucleotide sequence ID" value="XM_035970276.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855499"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="49"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826169.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="58170" checksum="CC775E5835C16C87" modified="2025-10-08" version="1">MLWYIPPHKCATLANETEVLNDYGLVNDTSASFHYQKCSIDLWTNVTGRLEQVAAMRCLNGMDYGGQQHISFVTEWNFVCENRTGFTEFVQTVMMIGQGVGAVLSTSVADRVGRKPVFILCNLCMFLVGLGGVFSPNIYVFLAVRFFTGFFQQGTGLAGFTLLMELTVPEHRRYVGVLGGTNWNISMVMLALTAYLMRDASWRSMQLVTALMALNALIYPFLLVESPRWLIANKKYDQALAVLKRACRMNGKDFSKVQKLFNRKIRSVENGLSQSSEQQPDSEKYNVLDILRHKSLLKSSLVIWLTWITCSITYYALVLASSSLAGNRHLNFFLMALVDFPGDLLIILVLDRIGRRFLAMFSLGITGSGLLTASLLMAYGVSGLERTLTTVFSLVGKFGIGVCFSCLFIFTPELFPTNLRSAGLGMCSSVSRFGGMMAPYSRVLADVVLWGPGAIFSGMCFLSGLLFINLPETKGRSLPATIHELKRWNSGKGEQKTQKPLARDMEIEITPTEPSINGEKELIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVW5</accession>
    <name>A0ABM1VVW5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33 34" type="primary">LOC101852420</name>
    </gene>
    <organism evidence="32 34">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O</text>
            <dbReference type="Rhea" id="RHEA:38379"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:38380"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38219"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38220"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38163"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:38164"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38435"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:38436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:37915"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:37916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-O-(9Z-octadecenyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:55340"/>
            <dbReference type="ChEBI" id="CHEBI:34116"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:197429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:55341"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:55344"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:138735"/>
            <dbReference type="ChEBI" id="CHEBI:197429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:55345"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38307"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:75729"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38308"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:55296"/>
            <dbReference type="ChEBI" id="CHEBI:45479"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:138722"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38439"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:38440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:37911"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:37912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38071"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:38072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:11488"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:63410"/>
            <dbReference type="EC" id="2.3.1.76"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:11489"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:38175"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:38176"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:10869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hexadecan-1-ol + hexadecanoyl-CoA = hexadecyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:38167"/>
            <dbReference type="ChEBI" id="CHEBI:16125"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75584"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:38168"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA</text>
            <dbReference type="Rhea" id="RHEA:38211"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75586"/>
            <dbReference type="ChEBI" id="CHEBI:75608"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:38212"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:38171"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75586"/>
            <dbReference type="ChEBI" id="CHEBI:75587"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:38172"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homodimer or homotetramer; both forms have similar enzymatic activities.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 29">Endoplasmic reticulum membrane</location>
            <topology evidence="8 29">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 29">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940032.1">
        <property type="nucleotide sequence ID" value="XM_013084578.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826557.1">
        <property type="nucleotide sequence ID" value="XM_035970664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852420"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027251">
        <property type="entry name" value="Diacylglycerol_acylTrfase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500231">
        <property type="entry name" value="Oat_dag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 29" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13 29" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 29 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 29" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 31" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00001349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00001764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="RefSeq" id="XP_012940032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="RefSeq" id="XP_035826557.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="73453" checksum="37679B419DD1DB0A" modified="2025-10-08" version="1">MKGSALISSTEYMISKEEPKPTLMAFEARKLMRDNSVGSTDSFDSDGQFCTEARCIMDGKKGYESLGRSVCSDGQIADSDDSGENTTSGFSSQQETRSANTVSRHIKGEFVKTVSSLGSRKKVFQHQRQQNYKLNESSKTSVLQKMCKLCGGEMQEEVTDTEVEEDSKPGIFTNSCQVLKRSLSNVMPDWIMEPEYMVHPKPRVNKNIVHSHADSLFSTSSGFTNYYGILNLCLILLVLANARLFLENIIKYGILFNLSFTEWFFKEPYNWPNLILTSSIAVYPAIALLTEKALSKGYISEKFGAAIYAVDLLTLLVLPAAVIYYLHPIIVFSISTLGIVTICFLKLASYAHTNSWCRKHHAANKLKRRRSVDSGPDGATAVNSSGSGPQVYPNNLNVNDMVYFLFAPTLCYELNFPRSARIRKRFLARRLLEMLFLSWLMVALVQQWIVPAVNNARQPLAEMEIFKMLERLLKLSIPNHFIWLIFFYWMFHSSLNVVAELLRFGDRVFYRDWWNAETVSEFWQNWNIPVHRWATRHVYKPLLKKGVSKLAASTIVFLLSAFFHEYLVSIPLRMFKIWAFTGMLMQVPIAYITAKYIRGKWGNIIMWLSLIVGQPVAILAYFHDYFIVRSLPFANGTMPNYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWM6</accession>
    <name>A0ABM1VWM6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Low affinity vacuolar monovalent cation/H(+) antiporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC118477112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005102823.2">
        <property type="nucleotide sequence ID" value="XM_005102766.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826818.1">
        <property type="nucleotide sequence ID" value="XM_035970925.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477112"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="12">
        <location>
            <begin position="132"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="369"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="598"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035826818.1"/>
        </source>
    </evidence>
    <sequence length="754" mass="83678" checksum="767835BE69B99D35" modified="2025-10-08" version="1">MAASNHNQVVSWDNAIEMENDEAVGPPPPISPQRKNVSETYNFSSPSRSGTTRHRTSMLFETEAETSNEFNVVEKAENEVEAKKIYNNYRFGLRKWKSHVSSRSIDSRSEIVQSLFSDISSYTPVRVSTFRISNILYFLLVGWWLALLYSVIGVVMCFSVLGFKHGKMCFRLARYFLWPFGKFVYQSVFIKPSMIREESETDGLGAVPACDHSEVTPVLPGRREGENDLLFAWSLSFCRTKNHPGTYLWFLVGLPVLWVVHAVLFAVSWFFVVTIPIAKINIKTMTRVLFMPADEVRVGDSGVGLKEGGLRRNKIIMYTHQAFNVYYYKYTVDGVNVIVANLLLFVILSIAIGYADSKNELTSPIMKCILSILSILPVTYYIGMAITSISAVSNFAVGAFLNATFGSMVEVLLFIMMLKKGRDDNETCFVELVKSTLTGSILCCILLVPGLSMVIGGLKFRRQNFNPKSANISSSLLFVAVIGVFAPTIFSKIYGNLECDSCEPHSEVNGTIKNGTGFLCSGCRTVTVGPDNNQSLYKAHVEPLVYTCSLILPIAYIIGLIFSMKTHTAEIFDDFENRQRDEGAGSHGGRAQWSRVKSTFILLLCATAIALSSDLISANIPPLLNASGISEYFIGVTLLSIVSMLAEIVNGIQFSLQNNVNLAIEIGSAAAIQVCMVQLPIIVLANLIYPMGFNAVFSDIHLWAIVFAVIVINYIFQDGKSDYFQGSIVVFIYILLMAMYFFTVTPEQAVCKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZS5</accession>
    <name>A0ABM1VZS5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101864477</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827918.1">
        <property type="nucleotide sequence ID" value="XM_035972025.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864477"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827918.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40562" checksum="E40E267C467989F4" modified="2025-10-08" version="1">MDEAKETHPGSEQSPVAAVIEPKKSTAFSIRDLLGLKSHHQQQQQQHRQHQSYHRSQNGNENNGQKDGESTLDVQRDENSSSDSSSSRISVDSNGNNVILVEDKHYRPFEHDSIGTRHGDHESIGEGVCDIINEKCRDACGNSKTSHLEELKVCVKSPETATPEVSGSNISAGIFSPVGISELKPARARTPGDVRDTVDSRPAREQHRLSLMSMGVRSSQGVMGVSDHSLENDPRWRGARMDAIHGQHSGQQMINFNIFSTGHGNRDLFGCADSADKSGVESPVFEHLHLPGQGKKKKKKRRHRYGIITLTICTFVYLFIPVFICLVDCEALVEPLLRLVNYSPVLHNRTRLSVVRVSSLSPRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZU7</accession>
    <name>A0ABM1VZU7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118478439</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827940.1">
        <property type="nucleotide sequence ID" value="XM_035972047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478439"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46670">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46670:SF3">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045666811" evidence="1">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="153"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827940.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49234" checksum="10BDB012639D98DA" modified="2025-10-08" version="1">MELVILTLALLNYFGHVYSFVVNSRSYHHVRVFPVLHPCALNQTGKTTKYTKDQLLNVNNPSLSVPSNVLTSLAQLGVRNSCVCQSKVVKSDKRGTRGGTRKQRKIMVCQGIPRDTVSKNRTTTTVNKKNLIQIDTRNVFQHNCPNLRIGCINTQSCCNKTNIVRDVIEEMNIDLLCITETWLRTEGDESIIADLLPPGFELKSFSRGSRGGGIAFIHRRGLPVKFICGGPSYRTFQSATAFIRSEQLTFRVTCIYRPPPNKKNKFTSKEFFIEFQDLLFQLEQAASPFYIIGDFNFHFDVPSVPDTKRLVSILDDHNLQQLIKEPTHRSGHILDLLITNTADQHVLKHQVLDKAISDHSLLIANINISKPKHVRRSILSRNTRTIDTQALRDDVSKTLTSLSSLDADTFHDTLKAAIDQHAPMVKRNISSRPFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W007</accession>
    <name>A0ABM1W007_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Outer dynein arm-docking complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Tetratricopeptide repeat protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC118478462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828000.1">
        <property type="nucleotide sequence ID" value="XM_035972107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478462"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040111">
        <property type="entry name" value="ODAD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040:SF2">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828000.1"/>
        </source>
    </evidence>
    <sequence length="693" mass="77832" checksum="144342D03B684465" modified="2025-10-08" version="1">MLSTVLEDGLKFLYDRVLFWAQNDNMPPAPPPPQKAQPNKRQVVFRTGRASQDGGSQAETEDDSADDQGQTNDAIDAVSIVNDPDPDVTRKQVIVRQRRADEIQKKESMVVVLKRKSKRHVPRIKEDAIEEEAPDASTINFNFQSLSGSGPETPTANTVRPSKGSVSFAMDQPETETESEMAPDDLDEAMRDRERKERYERKMERRRRREEAAERAEREREKDDDDRMERETGDPLKEYFTKVMDSLEKLNESGDFKGLRTKAEAFLLTMERYDNSVTPNKMAYVGKAHSYLGNAQMGLRNYDFALMHYDKDLEIGQRYNLPESVSRALGNIGRLHIFTKKYPTALKYLALKSKLPNSEAERAWLYHEIASCFLQLHHFQFARDAAIKSLQAATDGNDSLYQLQSSVLLGAIQVKLENFEKAYGSFEQAMDYAKLRGDKKAQQAITEALQEVNQRLAKQAREQVVKSDGGSGVDNEEEAKKTETKTSEDPATSAGTDIKVDHPNTSSMRKEHNKETKTEKIDQNQTHEQSSAKEPKTESGGVQKSDFPAGVKISSQTNIENPLFAVIQENSVVEDETEGPGLEPTPVDGETDQLEDGSAVKDEEVSEENVDQDEQVTLPGAREVSSDVLKVTYQERVITTESLAKSIAKDRGVREDLRLSLGSLKDVVMESVQKEANQGGPQGERIDTRGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1U4</accession>
    <name>A0ABM1W1U4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerophosphocholine phosphodiesterase GPCPD1 homolog 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828637.1">
        <property type="nucleotide sequence ID" value="XM_035972744.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854830"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="326"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828637.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="70380" checksum="E00B56C331543C58" modified="2025-10-08" version="1">MAQVEVVFNVDVETQKGHTVCLVGDDPALGAWDPLRGVCMQKNFSGQNWKRWVCSLHLAKNQVYQFRYYVCKDQRDLVPKQNGELNGFKQNHHVERPISVLKWETNVKPRTFSTEGVGETLELPVANFGKYDGVCHIGKGWLINQCEVQIRLHSNPIYMYKAKHREQSYSVKCVAMDYAKTQLASFEEDTDSMDGPPPCAASEVLVTNLSEDDCVPKEQGPAGMLYGENDYIVFRTQIPNPQNVGFQLDFFVFEPHRSPKFVGTSYLLPHKKIESQCVVKLPVIGTNHKPIGEVSLEMLLVTPLPILNLTMEQSFQTHWKWKQAKALDIGHRGMGASYSRVSMLKENTIASFAAAGKHGADFVEFDVLLSKDKKAVIYHDFVVNVAYTNKKSQKAKTELFEIPVKNLTLAQLQSMKLFVAGDNSVEINDEECPLEETEPFPTLEQCLLEVDANTGFNIEIKYPLVDINGVWEMENYLDVNETVNVILEDVFKCAGTRKIVFSSFDPDICILLQLKQNKYPVMLLHQGQTKVYVQYRDYRASTFSKGISFALSEHLLGVALHCEVLLQDLALIERVLDRNLVLFVWGDDNNNPHMIRRLRDLKIDGIICDRIDCHKPEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2D1</accession>
    <name>A0ABM1W2D1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metalloreductase STEAP4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828824.1">
        <property type="nucleotide sequence ID" value="XM_035972931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478761"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051267">
        <property type="entry name" value="STEAP_metalloreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239">
        <property type="entry name" value="DUDULIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239:SF0">
        <property type="entry name" value="F420-DEPENDENT NADP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828824.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="45404" checksum="18DA7ED7A831024B" modified="2025-10-08" version="1">MEVDMDGSARLVPVASDHSGPKQVVMDMARQLGFKPYDAGGLVAAQGVEERVTQLFPEWRLPVAITVVILCLWSVYVAYVYFIGRTVYSWEQIFVKVLNKPVAMTAITVFALTYLPGCLAGFLQLHRGTKHSRFPHWLDAWMRMRKQLGLVAFALACVHVFISAMTLSPTYYHSWFHHVDVTLHRNLTSDVVRLTLPAKSWMTWKGELSCLTGLITLVTFTILALTSIPSVGESLNWSEWRFVQSGLGTFGLLMCVGHTLVMGVPSWLSRNFRILSLLQSVTFTSTLLAVVVLLLKLVLATPCLRGPLRRIRHGWERGSPPISDEESGSNGVTSRDVMSSASTTRTSDLMTSRPYRNGGKHNAGSCCQENGIAMGDVGGGGRGGSDGNENGGYSNSCIEMNEQNVGKGGNTPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W332</accession>
    <name>A0ABM1W332_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transmembrane protein 267</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101861329</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005111425.1">
        <property type="nucleotide sequence ID" value="XM_005111368.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829075.1">
        <property type="nucleotide sequence ID" value="XM_035973182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861329"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026572">
        <property type="entry name" value="TMEM267"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13628">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13628:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005111425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035829075.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25915" checksum="195E04311417E642" modified="2025-10-08" version="1">MILSLLQDSSFITTMRQTILSLLQPAFPSPFVTVAMCCAIVAVCGLGDHLLVKTYSIKQSSRLLRALIDNSSHALIGGLSWAVVEGPALFTGSRAWLHCVLCTAIASAVDVDHFLASGTFRLEKALKLRGRPPFHNTGLLVLAVIVCWGLRGWHRSFSLLALMLLVGGLSHQLRDGHRRGLWVLPHGSSPPLSAGVYRGLIVLLALCARLLYCRGWGMAMEDVGGREKYYHRPTEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3V3</accession>
    <name>A0ABM1W3V3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myotubularin-related protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101854381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829346.1">
        <property type="nucleotide sequence ID" value="XM_035973453.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854381"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13208">
        <property type="entry name" value="PH-GRAM_MTMR5_MTMR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14534">
        <property type="entry name" value="PTP-MTMR5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF109">
        <property type="entry name" value="SET DOMAIN BINDING FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="6"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="1131"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1334"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1334"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829346.1"/>
        </source>
    </evidence>
    <sequence length="1813" mass="202269" checksum="82380E174B32981E" modified="2025-10-08" version="1">MSRLADYFVLVGYDHEKDRSGTSCGKILQRFPEKDWDDCPFMQGLPLFCQPVGWALYNQRQQPSFYVAVLTDMDGERHYCAVFTFHEMVAMTPCKPDDEEDEQEGSIIHHSSMFAPKSIALISRHDYIEAFRNCLGIIYTVHLENLTVKIETLVGNILGCVQVPPAGGPQVRFSIGAGDRQALQPALSASLPVSHISVAILFEQLGVNNTLTVFAAALTDHKILFYSESCSRLSDACRALTVLYYPLKYTYVFIPVLPTSLLEVLNSPTPFIAGVHAKLKDDIADLSKRSEMLDVIIVDLDGGSVRIPECVTIPPITDSILTSAKKALTMILNPDLVCADYAYAPSPKKLASHVHRDKELRSVFIRMFAEMFSGYRSSLAIVRIHPTPFITFHKAHFLGQRGMVEEEFLGRVIDSMAFSSFVAERGPPYRVCDIFDEVSATIQEQLQEEHNNPVRMMENIKELAHHLYLNECPSQQPYVPKVPKPTEGAYARIHQPAFPTLDGKMIQDIIDEGLYTNNTKKLNSVRTQNVRMVPMSSSIGAWSLQKTLENNARRLEVLKSCVNFIFDNKIPDARIIFPAVLRALKSGIARLALTQELGEHVRSNRAMLEHQQFDLVVKLLNCALMNDSSLDENGVAAAVLPLATAFCRKLCTGVIQFAFTCIQEHAVWGSLQFWEQAFYQDVQIQIRQLYLPLYEEHVLMKRSTDSASIESPNGSENGKSSTLVKPRQIGALEITAEQLRIWPTMSDEQQREMINNEESTVYSQAIHYAYRMVYLRVPLDASRSMKNIAIDENSSTVTPSVAESDSLDAESGFDETEQTDVAAVVTKFVSRFVDKVCNDGGVTQEHVRALHQMIPGVVAMHIETLEAVNRESKRLPPVQKPKIITPSLLPGEEVVMGKLRVYLLPDGREEGTGGNMGGPCLLPAEGAVFLTTYRIIFKGTPCDPFASEQAILRSFPVSSLTKEKKINVQMYLSHLDQGLQEGLQLRSNVFQLLRIAFDEEVTSDDIEAFRKLVNKVRNPATVYSTFAFTGYAVHASTQMQKNKEKNASLRQFAKRTLLKTARKAGLKKHNRNKPKYSITSPPTSRRSGNSSPHSTDSESECAGSVHNDDLSVIDENELIPSYSSDPKNVERLMERHAYQDYQRLGLGSVAMSGQRGGRSEPFRVSTVNSTFQLCRSYPGLLVVPQSVSDESIRKFSRCHRQARFPVITWRHPRTRALLLRASGFHSRGLMGMLKHNAAPSTSSGEASSSIEQEKYFMLLVAATPSSHRSSNNALVNSASDSLTSLDSLMMIGVGGESLNIMPTTPEPLRHTASSGGSGAGGVVSGGGGVVGGGSGAGAVGGGRGEALDKRVSAPPGPASATKAKTASVGRVGSMRERSPNLNIRSRTSRDPSHGNLVDNSIKSLHHVALYVLGEKAQMKGIKMESFPKCDFIPVDFYEVRQVKASFKKLMRACVPSSPPSHPEHSFHKAVEDSEWLLQLQSVLQLAGAIVDLLDLQGSSVMVCLEDGWDITTQVMSVAQVMMDPYYRTMEGFKTLIEKEWLGFGHRFSHRNNQTAATQTSGFAPIFLQFLDIVHQIHNQFPLSFEFSQYFLCYLAYHCSSNRFRTFMLDSELERVEAGWLLEERRPSLGSDSRSEDSTDHHAKLHLPGLTDHRQGMSDHRHVPCGASLWAHIDKQSKLSPAFFNVAYAVEEQEPILRPYSNVSNLKIWDFYVTEDLSRGTPYDIDIEETDGLREELEAEAMGVTRRQTLNACYHNIERVQPNCFWSKIEELHRIECDMGIKPSPWRAVWDRLECPGREQFHRQVSLNTKLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W483</accession>
    <name>A0ABM1W483_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101850695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829476.1">
        <property type="nucleotide sequence ID" value="XM_035973583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850695"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="738"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035829476.1"/>
        </source>
    </evidence>
    <sequence length="899" mass="98384" checksum="508D9BE1E2414FD4" modified="2025-10-08" version="1">MGALKFLDVINKCKDGGSSLEGTEIRNTIVLTFAFQAVFTAFNALQNLHSSLHDEESLGMLCLSAIYGTAVISSVLAPTLIGIVGAKAVLVASFSAHCIYILANFYPSFYTMIPTAVLLGTFHGPAWTSQSLYLSACAFSFSKSSSTSPYTVLSRFNVFFFAVFATTQILGNLVSSIVIRDGVGNRSEMVIFKYCGSDDCPANENATQIEDPEDWVVDITLGFFLACALLGLFLVVFLLKPLPTSDWSQKVKATSSATSCFNVLISTNMTLLVPFIMFTSMEHAILLGAFTRSYIACPIGIHMVGYVMAAYGATTPVFLIIFTQVARVTGRFVLILLALSIHLVLLVILFQWVPTIEDEVAIFVIPMVWGVAESILQAQANALIAMLFPSQKEPAFANFHAWRNVGYTITFMNVGYLCVSTKLIVAMSCLVIGALLYALVEVKTKIQEKASLKETPPVEVEMVQDIAGHVTLRKISTVSSSLSVHDRLSFDRIELADIINEAKGGWRRDGDSFTLELNKVMSKEHLMESKVTTWYHTRPALTDVLNTVVTPRDVAIQRSQSDGHLHSAPYRLGVHAKHRRGDKKNNARATSLDSSKRPKSWAKHGEPVSPGITSIPEDVFEEENEVSGRGRGGQEVKFVIGGFGGSHETEDADHHGGSSTNVSSNGHVGPGGQGEGHTNATHNNFRLSSDSSAHSETTNSPPPNFTLFVEAPEEDQNVDGSHDNQAFEDDVDKTITLEIVNPETKSKGSGAKTKHKPEPLVLLNQLKLNKSKNKLSPTTKTANGGFGDPDRDLKRSPLHSLKFGKSKTKHKSSSDLKGLKRERHKGSLPLSRSHVDFSQHNANNSNYHDYDNDSDGFVDDDEVQDENDNGYYGNIMVYSPKKKKCPVPKMESEDVNCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q962P1</accession>
    <name>Q962P1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100533265</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2006" name="Cell" volume="127" first="1453" last="1467">
            <title>Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Edwards J.R."/>
                <person name="Puthanveettil S.V."/>
                <person name="Kohn A.B."/>
                <person name="Ha T."/>
                <person name="Heyland A."/>
                <person name="Knudsen B."/>
                <person name="Sahni A."/>
                <person name="Yu F."/>
                <person name="Liu L."/>
                <person name="Jezzini S."/>
                <person name="Lovell P."/>
                <person name="Iannucculli W."/>
                <person name="Chen M."/>
                <person name="Nguyen T."/>
                <person name="Sheng H."/>
                <person name="Shaw R."/>
                <person name="Kalachikov S."/>
                <person name="Panchin Y.V."/>
                <person name="Farmerie W."/>
                <person name="Russo J.J."/>
                <person name="Ju J."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="17190607"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.09.052"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2015-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Shamseldin A."/>
                <person name="Moawad H."/>
                <person name="Abd El-Rahim W.M."/>
                <person name="Sadowsky M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="AF402096">
        <property type="protein sequence ID" value="AAK94482.3"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191502.1">
        <property type="nucleotide sequence ID" value="NM_001204573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q962P1"/>
    <dbReference type="GeneID" id="100533265"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051378">
        <property type="term" value="F:serotonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11497">
        <property type="entry name" value="SLC6sbd_SERT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF279">
        <property type="entry name" value="SODIUM-DEPENDENT SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAK94482.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="NP_001191502.1"/>
        </source>
    </evidence>
    <sequence length="631" mass="70559" checksum="BDF3800CD25BD8E7" modified="2008-11-04" version="2">MTPGPELPLMDGTPTKLIDKPASKPEPERESWGKKIDFLLSVIGFAVDLGNVWRFPYVCYKNGGGAFLIPYLIMLIFGGLPLFYMELALGQFQRCGCFTVWKRLCPMLKGIGMAICIIATLVSWYYNTIVAWAVYFLFSSFTNSPPWLSCNNTWNTPNCTTFSDRILPYTEKCETEVLSYNHTMLNTTAMMNDTEAGVSIHLVNATQYKRAVCRLVKEVDTSGNFYATAASTEFFERNVLELQHADGISSVGGVKTTLALCLFGVFFIVYFALWKGIKSSGKAVWITATLPYVVLLILLCKGCTLPGAGDGIVYYLSPQWEKLLNLEIWIAAAAQIFFSLGPGFGVLLALSSYNKFHNNCYRDALITSATNCLTSFLAGFVVFTVLGYMAHVQHRTVETVARQDVGLIFVVYPEAVATLEGTSFWAVIFFFMLIMLGLDTTFGGLEAIITGILDEWTFLRRHRELFVAGLMLWCFLGGLVTTTYGGIYVIQLMDTYGAPISILLIVFLEAVAVSWIYGVDRFSHDIETMLGTAPGPFWRVSWTYISPLFLLVLFILSLMTSPPPQYGDYVYPYWSLAVGWLIVCITLVSIPIFIVISFFNSKGTFKERIYQMITPTEVPSHVPKRDAPVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAK9</accession>
    <name>A0ABM0JAK9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Wings apart-like protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101863784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089258.1">
        <property type="nucleotide sequence ID" value="XM_005089201.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012935148.1">
        <property type="nucleotide sequence ID" value="XM_013079694.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863784"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="3">
        <location>
            <begin position="710"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005089258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012935148.1"/>
        </source>
    </evidence>
    <sequence length="1282" mass="141654" checksum="A7EEC418488D5E57" modified="2025-10-08" version="1">MSEEEPPHPRFKGRTYSRTRQSVASRAFDEAMDSKTVPVKAAMSVTKWGNANYIPLRGSADGASEVKKMKLESKGEDPFSFETEDKRKSPTKKDSAPPPDIRQTTRLPASRIVVKGEGNANFEKNAEERETTKAPAFRTYSRTTPKKPVIMDQFVEVGKTTVTASGEQVFLPSTLSPKKEMKNKEEDDDDDIFPVQFKRDPLKTYSGEVVTPVDKPDSPPPRKSSYKRKGGPRGRKPLTVTDPDLIEEYKRNYAAQQLKGKPDTSTGGLNNSMVVSKKEVANEDQGTTLVVVCKPKAQLEKGEVQTKYFTKNAKSTKGIVVPVAPDSASSQETVVSGENGNGEASESSTPNSDAVPTRSSARLKATPSVAAHVEGSPSTPGSTSSLTSSSSPVSPVKRGTRGRTSDADWGSAQSGTTTSAASSDNNSQGDGSSGKTGKRYRIFKSRAPAPAPVVEDELKPPVFKDELEESPLPSSDQAVESESSEQVASENNEKIEEEPFEEESMDTGEAEEKSPSFTPEDSSQCADSGEIGAGDVEDDSSNVKPINPAAARESLAARLRNMEKGNESDSTEPDNVSECSENFQSQESPSNSQSTAEENSQKEASNVGAVRRFFKSKKSSSSGSDLQRKIFSGSPQKSPAKATYNARSWNNDSERDGEKEGPVPKGSKRNNKTDDDDIVLVKNLNKSQLKREVHWPETKFDEAYTSLRVSKTHKELYTVVHNVKQTHEVQELGETQDFMDDVDYLLDSLQDTKSTSIRCLSCLKLAGKCIMPAFRMHIRAHGTVTKIFSLLHDACTDPSLALSTSAMMFMLSRDRLNMDLDQESLNLMLRLNEVDAADKSSVDASSLRELEKTKQRVQELLAQLQQETNAREIDLGFVSTGNLAMESLLSLTSRRAGEWFKEELRSVGGLDHIVDSVAACEKSLPENMSKDIYKVLPILRKLDRCLRVLENISLQNEDNQNYLISYKQASLLSSCSRTLRLCQRHMGEYKVLENPEEDKAVKDLPGYTILTCMLAVLRVLLNITHERKLGNFKESEETSLMEAIVRCLTGTQWCIPVEQRFDLSILCLGLLINLVENQVANRKKMMEMTTQVKYTEKAQAKTMHVFNAVVQLFVQREEAAREMEEDTEGAPDTSTAESPNKSGEWKESDSGIQWITSNLKKAKEEQEKEKEKEKQSESKIVEEEGNQSILEDDEETFTKALHKAGKHMENSIVASYAGLLLGTTIMDNKEYADKLKELIPNSDLGPMIKILKKFLNFMSLTTAFGSTDVNGITRVIDVLESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCD7</accession>
    <name>A0ABM0JCD7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101845375 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101845375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090451.1">
        <property type="nucleotide sequence ID" value="XM_005090394.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090452.1">
        <property type="nucleotide sequence ID" value="XM_005090395.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845375"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068:SF14">
        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090452.1"/>
        </source>
    </evidence>
    <sequence length="805" mass="89414" checksum="11C77C6F085B821A" modified="2025-10-08" version="1">MPDGNSRYRRPGSSRSSSSSSGRSPTRRARSNNRPVSRYSRANSPNQSLNHSPDNLDTTLLLRPVRRSSFSRTASVVSRPLLPTCKKPCGAPGSGSPTPSPKSAGCTPCRPSVRRCCRKPRTPPRSSSLSDPSRKCLLCKPRKPCYLCSPCKPLKLCNPCDPSYPCKPFDTCWPSNPCRPSKLCDPCRPSKPCNPCRPSKLCDPCRPSSPCNPCRPTSPCDPCWPSKFCDPCSPCRPRRRIPRKRFDPCNPCDPCKPWRPRDPCDPCDPSKPWKKPCSPCDPCQPGRPCDPCNPSKDSPSISKQEIKSGKIICDKFRSVCYPCDVPTKCRPRRCRTSCANPCDPCDPCRRCKPRCKSTPCKVCKWDPCTCTVTCSEKPTCQVTAACPPCGTKDTGPSRALTKAATRVGKCLDRFTPHMCPWEADVTVSGTVRGHCTSTAAEVANRLTGCFKSSGKRYTKDSYKCISSCDTQPQKFRLCALDDGSYMNFSRNNIPTSSNGGPLASDHVGKRTSKVPSPSPLRLELPKAKAGDFAAKEISDRNTEQGNIDLHVKPAPVCQKTKEGRKEKIIYDSTDSTDESDGVSDAEDRDEGARYDKGVDSGIDNVLKDKDQALWRPSQYNGCTAYLQRKRGDSTNNKHREKFLMKCNSDSNVVAPTKRSPLLSRYKTPHSSEIISPSKNMKKSKDRVFFSPSCRRGREKSNNEQCSLSRESRVKNRQRDWSPAKKYPERNPDGRCSQNVELSPPRLSCNSRSQDSSSNFRATKTGAFVHVRTRNGDSTERSRSKAIRLSVSPCSYKLRTYVPLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF23</accession>
    <name>A0ABM0JF23_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092231.3">
        <property type="nucleotide sequence ID" value="XM_005092174.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847314"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005092231.3"/>
        </source>
    </evidence>
    <sequence length="143" mass="15622" checksum="8E341780B48A2B5D" modified="2025-10-08" version="1">MADSFRIIPFRCVGYGCAVGEALRNRMCDDCVDTCYGACGVFMVAHVFFNGLSALMTGKGVVITIVDTCIFEFLASLVIPTFISYNTRRIVRKIVHNVRDTPVPVIKWGPTVAALLALAVSMKPVDGVVDLMLSATIRPLEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF40</accession>
    <name>A0ABM0JF40_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-like protein 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092261.1">
        <property type="nucleotide sequence ID" value="XM_005092204.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854624"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092261.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="68177" checksum="E41FABB4B1C16435" modified="2025-10-08" version="1">MAASNPQKEEEELDDMKLFDEIMIAPHKIKYINPRYKKVNAKMYDYKCDIKLSVGGSNFKAHREVLMQASDYFSAMFSHDMLEKEQDVIELLEMSPNGFTLLLDYFYHGHVTLNPDSIEDVLEAARFFQVDWVVEVCCDYLVHQLSIDNYQTVLQLADKYQLGDLRGDIFRFLGLNVMRLSEEKDFFLNFDRELLTKFLKEDVFVEADEEFVLELITNWVSAKPEERQEYLLPLVRLVRFPLMDADSLSGIHGDLLKWPEVADAVEEAKHYANDIAGQSLFRGPQFMSRGARPTVAMLIFTPDYCTVTYYDIDSGARCQEELAFSGEESQFEFSSIARVGNFLYRSGGYDERVCSSALVYRYNPRYRNWIQLASMAQPRVSHAMCASEDQIFVFGGIEHTVGDIGDEDKILSSAEVYNVRDNVWQDLPELPAGSYNQAASYSDGNVYISGGISADPFDSVPMCTLWRYDIQNRSWHNQRDMLYSRQRHSMTTVGNKLYVFGGYTAANAGPTEVFKDCFSNEVFDIETNQWTEIRPIPETFGHVMRTVGVWNGRFFLFGGGSLHSYYIDEDRMEYGDYVGLSVQKIAVLDVAFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHD4</accession>
    <name>A0ABM0JHD4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arginine/serine-rich coiled-coil protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093699.1">
        <property type="nucleotide sequence ID" value="XM_005093642.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845453"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22426">
        <property type="entry name" value="ARGININE_SERINE-RICH COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22426:SF2">
        <property type="entry name" value="ARGININE_SERINE-RICH COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="2">
        <location>
            <begin position="457"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005093699.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="61864" checksum="B6B39B608A29897F" modified="2025-10-08" version="1">MDLLSSYDDELSNTSNTEQVISKSRDRESSSTRVQSEWENFESAITSGNPSSARSSYPSSMSQEDSCASGGPQSESETMSVSSLNTKPVVSDNAKRSVEEDDEDESHLPPGVRRKNRCHTSSSEDEEEEKKKGSESSASDSESDASPRRDAAKNKVESENNSVKENSKSTEVSGSSKKARDSRSKSRSRSPSRRKRRRSSDRSRHSRSRSRDRGHRKDRKRKSHRSRSKDRRRSRDREHRRRREHKRSRSRSRDKRDRHKERRSRSRDRSRRERSRDHSRSRDRSRSRERSRRNRSRSSSPKNVIKFGDKVIKPGASFGRPPPSKPMTFKEKMRQQLIKAIEGGGDVSSALTNDDGTALCTQTAGTQQMPAAKKPPVPLMANLVTSTAGLSAMTVTPSEAAMQSMLAMQKEATAKTGVEIPKYYNPAAINPMKYAEQVQKRKLLWSKNKDKEVVSQWHATTLSSDHDDKSKEKFRKLMGIRQESGDKDGSESEKVIEEQQEQKQREIFDKLDKEYQYARMATHTHRGIGLGFGSASYQQPPTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHH4</accession>
    <name>A0ABM0JHH4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Polyribonucleotide nucleotidyltransferase isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101859084</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093761.1">
        <property type="nucleotide sequence ID" value="XM_005093704.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093762.1">
        <property type="nucleotide sequence ID" value="XM_005093705.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093763.1">
        <property type="nucleotide sequence ID" value="XM_005093706.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859084"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005093761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005093762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005093763.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19998" checksum="192CB659485FAC75" modified="2025-10-08" version="1">MADLAEIAAEVGIAVVDDVPGDGGDADTISAQDPGGCGGGVSSSTDDVSATVAWNSNLMPEVQELENLFSNRYNPDSDPGYVQNVSSSETASKPPAIKDFFCRRPRDDSRNWNRNRGGRGHYNHHQGGGDRRGRGEYYQNNQSHYGGRGGGGGNYPRDYGDYHQRNDGYRQRNYQRDRSPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHT7</accession>
    <name>A0ABM0JHT7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">WW domain binding protein VOPP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Vesicular, overexpressed in cancer, prosurvival protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC101847710</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endomembrane system</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Late endosome membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VOPP1/ECOP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093973.1">
        <property type="nucleotide sequence ID" value="XM_005093916.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847710"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026229">
        <property type="entry name" value="VOPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14971">
        <property type="entry name" value="VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14971:SF2">
        <property type="entry name" value="VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046175183" description="WW domain binding protein VOPP1" evidence="19">
        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="174"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_005093973.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29810" checksum="2AF423EDD7BD6AFE" modified="2025-10-08" version="1">MIWLGVTSFSLFVIEAFADYCGDELFCDSPYRCCETKRGCCYDSMLHHSKHFRLQIWNMWYFWFLIIFMMMSCFGGCGYYRRRRLALLTQSPSPPLRPTPRHVLSLQRHGRQRRANQESRNTAAYNYFAYNGPGVIPPETSGLPPAYAEVMSQPAMYPPNKVELPPYPGLVKPDGQMMYSPQGPQVDPISEPAPPPYSEFQYGPPPSEGAAAHIPTGVPAVGPEQMPPSTDHSCQPMPSPAQTSDASQVASVMNAEGSNNSNNNSTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI16</accession>
    <name>A0ABM0JI16_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 91</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101853534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005094090.1">
        <property type="nucleotide sequence ID" value="XM_005094033.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853534"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094090.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="65526" checksum="2077BEBDDB6DD631" modified="2025-10-08" version="1">MADISYSSIQMNINFEKNAVIRHVNLDVDGIAVKRGERRSKSRLSLRDVEHQDTSTSTSSGMNESEEKNRFLFLFDLKEKRPVVREESVEEPSFEWPCDVKAKGKGNVRSDVIENSCIEVKGEPIIAEEEIKVKLLNKEYHTDIDMVKTEPLFEHFTDFGGEVNPTGENFVKEEMGDLCVEPTFVEDHISQAGGLQLQISSVRSLSMEQSFYPDTDIVACSRQASIFSADPALLEYSVSNSGPVARTCWNHGESSGLRVVLGPTESENKRKTSNAMQCKAYRERNSDNLNYIERNKEKCKKYRQRVLTDEQLAARREASRLRTQKCREAKKLKKKPSLTSAPKLTRTHEEKPEMRETVEEQREGWKLQKEKQLASWTSQEWRHQQEKCRTYSRKRKQNLAQVDDAKSVPSSHHVSPTSCHIVDQANDMHRRQDESLSCQSGTEQRVSQENISSVRETPLLRNRKICSGKNPDKCCAVCGENNKCEVCCASLTRRDNLQNHERMHTGEKPYKCEVCGAMFARSGNLRKHQIKHSGEKPYNSEVCYASFSTKGRSTESQTNTHKRRTLHLKFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIB3</accession>
    <name>A0ABM0JIB3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Myocyte-specific enhancer factor 2A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC101858256</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005094287.1">
        <property type="nucleotide sequence ID" value="XM_005094230.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094288.1">
        <property type="nucleotide sequence ID" value="XM_005094231.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824613.1">
        <property type="nucleotide sequence ID" value="XM_035968720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858256"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005094287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005094288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035824613.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="42963" checksum="FDF3C74275ED6AB0" modified="2025-10-08" version="1">MGRKKIQIARINDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFTSNNKLYQYASSDMDKVLLKYTEYNDSVVSQTNKDIVDMLSKKENKGGDADGDEDDFPISPRTDENYRKIDAAFARAMNDGGMKTQQIQYQLPGQVPTSQYTATPASIASGGSVIVLQPPTGPIAHSVPSPSGSRVSPVQASTSVLSSGQVSHTVSATQPVPIALHHVGEVQQQTISVAGASTSSHPSGTPTSAKKHGLKVVIPERPPAVGQPRAQPGTALDTPNVSIATPNQGGPHGAIQAILSSASFSGDLLNSADIAGLSPLVYQLSSAGAGPGPLTAALQASGVTFTPGGSVTLSGTPTTISIPLQQQKGGLVKQEPGSPHKPEQIVAGSSVTPPPNQPSPAPPGGDDEPPSKAPRLDTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIQ6</accession>
    <name>A0ABM0JIQ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859919</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094560.1">
        <property type="nucleotide sequence ID" value="XM_005094503.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859919"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094560.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14369" checksum="82543B7C95488111" modified="2025-10-08" version="1">MNHNLSQSEVSQMTGNREKYQKFYKSFYKHRHFARRSNMFGRLIFFLVGVYAGVVANQRYQIPEAPMPTELWEKAKAMAEQYKKDNPDAAEGTSQAPQELSQIMDRLKELEKTYRKDPKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ25</accession>
    <name>A0ABM0JJ25_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase family 16 member A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094794.1">
        <property type="nucleotide sequence ID" value="XM_005094737.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852840"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="1">
        <location>
            <begin position="559"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094794.1"/>
        </source>
    </evidence>
    <sequence length="815" mass="86954" checksum="DA2CB544CF1D0B53" modified="2025-10-08" version="1">MAGSAGVGILASDELCYGSAAESESVARLWLDKHNKCFGQFVNGTWNKTEGRATVDVKKPTTGEKLATVLKANDEDIAFAADNSKQAFKSWSELSGHARAQHLYSIARNLQKHQSLLAVVEAVSSGQPTRETRGLSAPAAIRYFYHNAGWAGLMEEQMRGWKPYGVIAIVVPAWLPLVQMAGKVASALAMGNTVLVIPPASDPLSCLLLADICSQAGLPAGVLNVVTGADVMRVAAKDGLDKIVFAGSASEGKALRQMTAGSGKDLSLEMFGRSSVLVFEGADLDSAVEGIVEAAFFNSGQTFYTGSRLLIQETVYKAFVQKLKARIYKLTVGDNLDKNVDQGPLLDDQTFSCVASLVERAKAEGAEVVQACDLSTVRQNSFPPTLITNVQTSSEIYLKEVLGPIVVAVPFRTVKESVTIANHTPFGLAASVWTEDLTVALEVAALLQVSTVWVNGHHMYDAASGTGASKASGFGRTGGKEGLYEYVKPSWQNRLIFDGEVDKKFGSASSPNLLPGAQVASGGSSGDGPGVDKTYKLFYGGGQKRPDSGASRPVLNRGGTVVGYVPDGGRKDIRNAVEAAVKAVGSWSKKEGHGRAQIMYYLAENLESHKEEYAALLSTMTGQELSSSAQEVQQAVQRLFYWAAYCDKYGGDLQETPFSGFTVKRHESVGTIGIVCPDEAPLLSFISLMAPAISRGNPVIAVPSGKYPMAALGFQQILETSDVPAGVVNILTGDSDVLARALAEHHDISAVWYFGSEAGSRYMEFASAGNFKRTWVNYGVSRDFSSPEQGQGPEFLYQATASKCIWLPMGTIFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ27</accession>
    <name>A0ABM0JJ27_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101853301</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094796.2">
        <property type="nucleotide sequence ID" value="XM_005094739.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853301"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094796.2"/>
        </source>
    </evidence>
    <sequence length="350" mass="37821" checksum="DC79DB368C8467E0" modified="2025-10-08" version="1">MDGALFNSVFNRCVEKGNFIDSEVIEPGEVTSRGSRTRSVGESVVGLLRKKPSFDSCDVRKNVMNKSVHQGNPAADFIPRSSLYSVQEDIIESCEKRGGIGNDVGLVGEMSKHLDLDGLIDIGKAEHFVKQEVMEGPDIAEKGETYEYIMRDGKEGQSVNGNHASDSLCLLSQSEERKQLFLDVRSLCHVQQRVDPQTSAAAYESVRTDYVCVSQDPSSLTHTDSNVASSSAGWERDGQGNDSLSSQNSIPFDLNINMMVNETSATTSEGHKHFKEGPSPLPAYKLPGSSSGLGSGRSKRKSSIPCKSVAASSSSALEEGESVLDEMDCSVLKSVARPDTYQPDLGHIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJS3</accession>
    <name>A0ABM0JJS3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Heme transporter hrg1-A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101852614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095312.1">
        <property type="nucleotide sequence ID" value="XM_005095255.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852614"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026218">
        <property type="entry name" value="HRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31525">
        <property type="entry name" value="HEME TRANSPORTER HRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31525:SF1">
        <property type="entry name" value="HEME TRANSPORTER HRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16954">
        <property type="entry name" value="HRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02095">
        <property type="entry name" value="TRNSPORTRHRG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005095312.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18938" checksum="11AE86BE01C07CF6" modified="2025-10-08" version="1">MEDYIEVRQISSCAIKSRIVFSTIGVFVGLSICAVFGAHYHNYNVALWGLTSGIAAAVALGVTIAYIKHMWDSNPRRLKGFMLAGCFIQLAGVCGFVTYLVLAITNNQDLIVYGPGYYLTCVWCFMTWKWGFWLLIYSRSFLRSYGDADRMIQGEDVVGKHSFYQSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKD4</accession>
    <name>A0ABM0JKD4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor MYB120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095758.1">
        <property type="nucleotide sequence ID" value="XM_005095701.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858259"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095758.1"/>
        </source>
    </evidence>
    <sequence length="617" mass="67469" checksum="D2890099232DF407" modified="2025-10-08" version="1">MSSRPPSYEEAVLYPVEVRPDNSSQQQQQHHHHQHSGQRPEQQHRQQQPCQNPRDDHSHFSPLAPAVLNAIPPSIPHAGTASCPYTTPSSSSSPPDHSGQTFEHLEVTRRPPGLTSTLDTPSIVIHSAHSTPGEDFSTVDDMFPEQENNSQPQEPEPSGHNNTGIILDGHHTDDTARAFQCPNPHQTSVIGENGSLTSELQQTWATGGCSTTVPQLVENPQTSSDRLKDIPQQREDPIIPEPNATDASRVVSTNEVANANERVRAYKVNGNTPGLRYHNTANGANTTVVEVDNSILSDGRDRDETRIEMDEDISIPGANSSRKGNNSSCTQQQGAASVDTDVCDSLPSDKLLSESRTGVIIGAPSTGASGYDHQGYNNTQGPSARPKTNLGAGLGGGGGLIPSTHKMSRSYNDLSSRSKGGCRHDLIYMERVHGNSPACAVHSNSRETIPFHPNFHHLHHNHNYHQQQQQPHYKRSANNLGRSGRCEEDSDHYHNNPHQSQKQHLLPESRTFHGSRGMRSVSADDVRVRSGTDEYVWKDGKVQLKNGGISHGESVRYVWKDGHVEKITTDANNEDTQVEVLETSDGKACSKINPVFVCVFLIGVIAVVIILPVYYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKT3</accession>
    <name>A0ABM0JKT3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-succinylbenzoate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096051.1">
        <property type="nucleotide sequence ID" value="XM_005095994.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849198"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42814">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42814:SF3">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="229"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="416"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096051.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="64298" checksum="CF34F685D967A7F6" modified="2025-10-08" version="1">MGANVSLEKYPTVPERLRVLAQEVPDRELFIFHGPEGRKSLTAQEVYTLGGVFASRLRSYGFRKRDVIANMLPNCPERLISDVGIILAGCVTMNGQVIYKEGKDFFLNCRRSGCVGVIMICDDHSKPWDLLKDYLVDWPSSGLAQMTCEFAPNLCKAVLVSRQEKSTCQPFLQDLTYSDEPLLEAEVEADDILMIFATSGSTGNSKLIPRTHAQTFAIELIVDQLKQSQRIWRALVSEQCAYAMVHVPQIEHIVSSLHQMDTPPFKLKYLGLGGQPVRKHQFQKCFLLGHCVTMAYACSEAGYMACATIYPGDSVPDDFFCGKPSYFGTEVKVLDPQGKPVPVGQTGNIYVKGPGLFSGYLNIDKKTEQNAAVFTADGFLDLGDLGHYDHGGNLYVSGRTSDVIMHGTHLVYPDWIETKLLEHPRVATALVVPVSDPVYFHKICAYVQPTPGNDITEEELRKFNEGGKIKAELPVVPTGKPDRQAIRSLAEKMFGRTQPGDEIDKFTLKCGDRTVSLSQKEQFVGKLMTKVNKLEQFLLLAPPQLSKITVSASQQSSVWLGEPRTPMFFIDYNDKKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLR6</accession>
    <name>A0ABM0JLR6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101848287</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101848287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096657.2">
        <property type="nucleotide sequence ID" value="XM_005096600.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848287"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045667827" evidence="9">
        <location>
            <begin position="25"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005096657.2"/>
        </source>
    </evidence>
    <sequence length="634" mass="68789" checksum="617750EFF311CE7D" modified="2025-10-08" version="1">MLSLQKVLFHTCWLLFCVFGLANSAQDASSTNLGFSSLNSNSSSEPGEGPPLVLSVVSNMGRPHVLLFTLEVNVEFKATYSVFCSSPEDVYIVQAKSAKPSIAEFLGNTMFNVSCELSRAYFENSPDVAEKMINSTLEASETENNEPVNFPEQVSYNTSTSVATITGTAIFKLKTNNIGRTFVMFFAFRKDGPIFQNSTRSPKKMEAQNTGNVASPSLPPNVVGKGVIIVMQLPRAIDKIFRTLLYIVIVTATIGMGMNVEIDIVKTVMKKPVAPIIGMFCQYICMPLIAYTVAKTIPQDNAAVSLGIFACGVVPGGGASNFLTYLLNGDVSLSVTMTGLSSIASLGMIPLWMLTLGETFEDENISLHIPFINIAETLSLVLLPLFVGLLLKIKCPRITAVVVKILKPALFIVVAFVLSVGIYANMHIFKMIKPMVVIAACALPYVGFLLGAVSALIFRQSWARVKTIAIETGIQNMAIAFIMLYLAIPPPDNQLASVAPAASSIMTQIPPLITVIIYTIYNRYKNKNKPPSDGDDKADDDCTICENGVEKNDVKSEINGVKSEKNGVMKVKDNDKAKEEGKGSSSSMAQTFLEKLMGREHVKSPADEALNQEIVVKTPEEEKLMKKNVDSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLR9</accession>
    <name>A0ABM0JLR9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101848964</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096660.1">
        <property type="nucleotide sequence ID" value="XM_005096603.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848964"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048839">
        <property type="entry name" value="SPATA2_PUB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15326:SF2">
        <property type="entry name" value="PROTEIN TAMOZHENNIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15326">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 2/TAMOZHENNIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21388">
        <property type="entry name" value="SPATA2_PUB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="599"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005096660.1"/>
        </source>
    </evidence>
    <sequence length="667" mass="73943" checksum="DD16FCF026EDAED1" modified="2025-10-08" version="1">MEALRQARNLYIKSHDYETSLSDVDKPQLKSDIQRFIAISLKESALQNIFANPCMLNVLNTALRDRAANNTDLAPVVKAFESLERYILLLVEQPWKPEYKKLKMYGGFYKTRIKSVLLYPEEIFFTAGYIATNDDVMVHKRQMDKASLLLLAFDCKIASVECKTIADHYSKVKNIGQSLGFVVSERLGDAGIREENLLGRGKAPVPEMDLSWQKEMRTAAPALPKRDPIHHTRSHQQRAFESAYATGLEAGLDGVELSHKQGSRFNGMRPYQDFGHLEQVKSPLPASESVQDSFPCIDTALEERIPELPQGTCDEHMRESLKFVSQEEGPRHPPSTSSHTSQGFKSNDWKWFRELQNNGHVPRNTTAPVPEGPQLYGQIGTSNPLSVNTYPPAVTNYKPSMYPNDDASLDEGFQTDLGGSSRFLQPSLQGSFSQVAAPVQQVPHGYQVPHAVDATYGLKGIPPQPQGSFGPTIYTPPVLDADSAMLSYASKQARAPPPIPSRALKPMLQTRPMRADNMLENASVTAASLQAADLSRKVYGTLSAPTLPNMRPPVPVQTSDTEPITRRDRFGAGGKSNSLKYGDEKTSAVYKVAQSRAARSMDMTLIQWKCTKCSNVNMASDAVCSVCTHSRLSTTKKSCPRCTFDNSVESTHCGLCHQELEDQYTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMR8</accession>
    <name>A0ABM0JMR8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="2">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101851122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005097343.1">
        <property type="nucleotide sequence ID" value="XM_005097286.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851122"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="7">
        <location>
            <begin position="232"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005097343.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="43096" checksum="D71CD2097DA28FA2" modified="2025-10-08" version="1">MSGEQRIIRVGTRKSQLALIQTNSVIQMLKALDPTLKFETLPMTTTGDRILDSALSKIGEKSLFTKELENALLKNQVDFVVHSLKDLPTILPEHLVIGCVCKRDNPFDAVVMHPKHTGKTLKDLPPGSVIGTSSLRRAAQVQRLYPQYKIENIRGNLNTRFQKLAEQDIYDAIILAVAGLERMGWHHCISQILSPEECMFAVSQGAMAVECRQGDEATLALLNKIHDHTTTICCVAERAYLKQLEGGCSVPVSTFTEINEDNQLHIRGGVFSIDGKESVEHTVNTHLDFPPVDIPDGPSFVGLHCQTPSKKNQYTSAWAAGVQLAEEMIKNGADSILAVAKAATKHQIMEEHERMKLEKQLKQQQQLQQQLSGSEAGASSSSAHSSQMSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN96</accession>
    <name>A0ABM0JN96_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein dimmed</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097679.1">
        <property type="nucleotide sequence ID" value="XM_005097622.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848746"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19725">
        <property type="entry name" value="bHLH_TS_OLIG2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF164">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="197"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097679.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="52908" checksum="584211B576C2E27F" modified="2025-10-08" version="1">MATEADTSGGETVVSSNSLRHKEHHNNHHRHHPYLYRPHLQQQQQQHQQHQHQHHHHHLQQQHQHVSSMAAHLHNSEATNFLFSHHHGSGGRLSSNTKNFDDDDADDDDDDENNDNKLISVDDFEDSSDIEDDRQSHNSFSPAPSDSTVNSSSCTRSLRQHDDSNNSNNNNNKNSSSKLRKKGGLASKCVDDQELQQLRLKINSRERKRMHDLNSALDGLREVMPYAHGPSVRKLSKIATLLLAKNYILMLNSSLEEMKKLVSDIYHTHAPPRTPVLPTASSAALPPPPPPPPPSQQQQQQLSSAGSIAAAAVAAAAAAAAASATSSPSVSSNGGSNPTVTSSSSAGMSLGSPSRTPTTPVSEHIPPLALSLHHPGLPASTLPTHSSVSPIIPLAVPALRAPLHGLTPHDLGALTSSFIAAKSEIPGAHSVHSPTHHHAHAERFHSLSRWPVPCACAQCLTGGSSPLQLGLHFGRFPHPLLTSSASLTRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNQ8</accession>
    <name>A0ABM0JNQ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen alpha-1(XIV) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097975.1">
        <property type="nucleotide sequence ID" value="XM_005097918.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856890"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01472">
        <property type="entry name" value="vWA_collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045429789" evidence="1">
        <location>
            <begin position="20"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="29"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="231"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097975.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="46495" checksum="5CF6543F9482C911" modified="2025-10-08" version="1">MLKVGLVLCFLAALGGAQGSNISCSQPADIAFLLHDSRNISAEDFKEMITFVKELVAQFDISLTSTRIAVIKFSHGTDVEFTFGVYNTLSEVERGLDAIQQRKWDETKLNSGIHTSRFILRANGRRDVPHILIAITSGLSDNRAETVRQANLTRGDGVEIFIIGVGSLDQVQLEEIASEPFSDHLFNVTEYSELSSLGGILSEKTCPDTGLTDIPSDQVAAQEACYQMPAEVVFVLDISSSIFMHDFQKQLAFVSSLIRIFDIGENETRVAAISFSTNATVEFHLDEFYDQKDVRDHVEMIRYTGGGTNTGDALKLVNDSVLISERGVRSNVSHVVIVVTDGRSENSTETKAQANVLKDSGVLMFAIGVGPYVDDQELEAIASEPSENFIFTIADYDTLTSIKNTLALRVCDVGIPGNQTEIDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP18</accession>
    <name>A0ABM0JP18_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12 13" type="primary">LOC101845999</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098185.1">
        <property type="nucleotide sequence ID" value="XM_005098128.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098186.1">
        <property type="nucleotide sequence ID" value="XM_005098129.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098187.1">
        <property type="nucleotide sequence ID" value="XM_005098130.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098188.1">
        <property type="nucleotide sequence ID" value="XM_005098131.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098189.1">
        <property type="nucleotide sequence ID" value="XM_005098132.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845999"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005098185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005098186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005098187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005098188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005098189.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19808" checksum="54AC2526AEF07F2A" modified="2025-10-08" version="1">MGKVISKLLGSKEMRILMLGLDAAGKTTLLYKLKLGQSVTTIPTVGFNVETVTYKSVKFNVWDVGGQDKIRPLWRHYFTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILVFANKQDLPDAMKPAEVQEKLGLTRIRDRNWYVQPSCATSGDGLLEGLTWLTSNHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP51</accession>
    <name>A0ABM0JP51_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101861812</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101861812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005098251.2">
        <property type="nucleotide sequence ID" value="XM_005098194.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861812"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF180">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="740"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005098251.2"/>
        </source>
    </evidence>
    <sequence length="909" mass="100721" checksum="8C388F0AA399B387" modified="2025-10-08" version="1">MAINKKRPVKSKVSPATQNSPYVHRDVRPRRVSEDVGGSDRVSIGRWVALFAVVLAVTGCLVSPDVRRVLVRLQKTGLGEIFADAHDPSVRISSNEKREAKEEEVVGWLDPEPPENLLDDIEDDGGWHEDQVDEDELTMDDFEDGVIEPEDTEDLMEDEIVEKERRDAERQEKEYKLKAAGNSASDGKGRSSKVAEEKSVKSPKTTSESGDPPLVRGRPGRDKNAPPPIILRPGDTHIKLDASQIKFVDSPVETKDKKQPKSQDSAHTAKKSKSSVKSVNTKPPGKSPGSGKAEAPEKPEHNSKSSAKQTKEKTAIKSPSETKQGNKATTKQAKEKTAIKSPSETKQGNKATTKQAKEKTAIKSPSETKQGNKATTKQAKEKAKSEIPERPGGNKNGPPPIVLKPGDNTILDTSQIKFVDSPEKEKPMKSKASKVSAKKSTPSSKSANKKSAAESPGKNKDETPKTAANVPSSSEERAKEKVEANSSENSREKQKQTNVDKSEAKTIPKTSKSKSDGVGTAKEHKPIILNGENDKIVIDPSTLKQVNPEVIEPSKSKTKTSDKSTSMKKDSAKVSAKKQGDGKIKEDTDSNNGVKEKVNKFRAKYQKTITPKKVFIDGRRIPPTELLHQKASNSSVKVYLFNDFLSDRECDGLIKAHDSHVKALDKQPLICFDSIKTLRSHLKEVKKSSVKVTPNDFTAGTICLNSTFSAKMQMWMKSNWSYSTAFYPGESQFSTRLAARIEQAMGLSEDNGGKFQITSYPVGKAYKEHTDCILGGTEKRDRMASVLMYLNDVEDGGETSFPDLGIWVKPRKGRALLWNNMNPEGFCEPHSKHVAKVVKKGSKYILIRWYYYKSFYALGKRQPAPNLPARDEAQPMVRCDEYEMGSCRWYDEWNHDVTLEYQKNQMKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQE0</accession>
    <name>A0ABM0JQE0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA-binding domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101861208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099103.1">
        <property type="nucleotide sequence ID" value="XM_005099046.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861208"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="6">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005099103.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29231" checksum="C961E3B906091132" modified="2025-10-08" version="1">MEEESGLEFDDLEEVFGSATEYVRRVSGKLESDKLLYFYARFKQAKEGKCNTAKPSFFDFQGKAKWDAWHKLGDMDKNQAMMEYISLLTNIDQEWRSKLSSQLNEQGDTDGGQTRGQTLGVSVSVMANTDSELSPDEKDIFDWCKEGNVEKVRELLTFGAEAVNGLDEEGLCLLHWASDRGFTNMVELLLSLDADINRQDMDQQTALHYAVSCDHADVAQLLMNHGINESLQDVEGNTAMDVASDDMKLLLRSLIEARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQI9</accession>
    <name>A0ABM0JQI9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diamine acetyltransferase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101863514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099202.1">
        <property type="nucleotide sequence ID" value="XM_005099145.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863514"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005099202.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19925" checksum="CC2B4478A251813F" modified="2025-10-08" version="1">MAQSSFLLRQAKPEDCDEIMRLIVELADFGKMAHLVHITADTLRKDMFAEKSLCSSIVAELAGSEPRQLIGYSLFFPIYSTLDGMSMYLEDIYVTPSQRGQGLGKKMLLHVTKAAFDLNCQRLHLAVLNWNKFAKDFYIRCGLIDVTETEDWHLMRMKRKEIENFVKDPKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR41</accession>
    <name>A0ABM0JR41_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846505</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099554.1">
        <property type="nucleotide sequence ID" value="XM_005099497.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846505"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487:SF1">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099554.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39238" checksum="4F88A4BFB8E7C005" modified="2025-10-08" version="1">MAYQTSSWPLWRKFIQNFKNGESNFHVSTKPLMVTFLHPGLRISSFDNYGKVDISDLLTLTVDVQNYAFYSELMPGGGTVFSWPTITQGRLLFVQSAEFSMTRAMQNQMLPKWPLQARLCLGRVGTSSVSVCVELLSPETGQLLLSHVKQLVTVDKVSRKPVPLPEPFRDKYRHEGVLQKPFSLERFAKPGNTFIYQLKVAWSDTDWYQHTNYASYARFATNALHQALVSGATQLPREKSSSESNTRTSFSSTGRSTGTSSDISGSPSPQSNELSSSVFQGISEDVVKNGLKTFRIVYFQECKEGETIDVHLWQQAGEMNVVRCHVNRGDQLLAQMTLEYFPTASDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS13</accession>
    <name>A0ABM0JS13_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101862041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100205.2">
        <property type="nucleotide sequence ID" value="XM_005100148.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862041"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="11">
        <location>
            <begin position="30"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="555"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1767"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1771"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1783"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1806"/>
            <end position="1817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005100205.2"/>
        </source>
    </evidence>
    <sequence length="1848" mass="204909" checksum="078A771D9AA1537C" modified="2025-10-08" version="1">MAGPTADSFGNRQLWQVISGTGCLRPQEYIERELNKNKEKLLQGFSFYKKQSTPQGEALKKERKLKATHREFVIRLSQLLGLDELQSHDLFCSFLFTEFRGSQKELTNILTHERHSQTLLLKVVDFYYGERLYILRSLRHILHCWFEGEHAYKDVFAKFLNELLEKSLLGEKLIDQFDAACNAPLPTKELNGPLMGRAQVNAWAMQNLKEQAELLELLVIYYKDFEMDVTTLLKLCVRFKKHGFGWGQDYKHLIDIHMEKLVLRIGFLEILVLLEGLDIMNALTAKEENNLSDHVILCDSANLEKLDKAVSMIGSEPVHSPILLGCAILLYINAEVEQCKEASGAGGESGGTAAKALSRAHIMGNLALQLGVFNVLLDLLETEPFSGKSDLASTAHYCVYSCLSALLAFFQEDSLGNTEIIYKITWKLLKWEFIANMMWEKSGSEGLAMLYDSARNWFPLDFVCFTQLNISLARAGGHSAQQVKKCMHQLGQYTELLDNNRSSDLQTTEEKGVFVLRRNKQPFQNSDFAIERSSKGRVMNPSTVRRDLSSLGHIIQWETTYNGWQMLMGEIQELLSQVSHGAGMVQTEQLIKVTMVMELIKEVMTSDPSSVTEFSEIFSLGYQLILRFAVLSPAPIELLSHTIHCLARAVPLFHTQVSHHLKQTGLLPFLTENIDDFSEVLSGDGVNQGLYGCLLATTECPQGTYLVTLSVLDLVSQLVVSFSKEGREREHTASVLYILREVFPRFHKWRYVDITQRKLIGQKCLQLFHNIFNFVNLQEKPQETGKGKKKAPSLQESCVFSLLFSEAGRSLLDIVTTGVDNIQQTLAQQCSLMEGAGMDLMELVEMSLSLLNRLLLLKPLRLGASPVEQALSSQPAGRQLQHPVATVAQYIYHRHSHRLPALATLLLKRLAMVSPMSILACLGSDAEPIRDMFLTRLQAVSEDVQLKVGILELLSVCVESQPGLIEIFLSVQHQQADAKDLKLGRSSCLPVLLELMSTSKQCTYECPPELLCASLDLVHALWHGMRETPMTVLRNTESFWPSVVAPLTSDLPAVQEDDDLSVQAFKLQTKLAAFSLRIIAMEVYAVSSSKFNDNFKKSMQSAFTSGRLMYWSKAVKEGMEKAGQAQGSTQVTYELTVADHPALNLLLAWKNFLIATSRFKVKEVQPLDRDCGDILHDLLCGVQAQFSSEQLTPVKVKLASISSALYFTLTKLWGKELLDRQLSETAGSPRTISGPAVAVRRLTQVLRESLADSSRLLPSVHIGLLGALTAILQHCGTKLDDLQTLIKSLLPVVCSVFLQSSWQLPGLIETAEVTGEVKETTDTEGTTQPLDSLGSHVKVQIVSCCLLVEILHVSPDLPASLRLIQENGIVSCVLTTMEAFFKARKGVSYIYSSLLLLTKIADTEAGANMLCVSNLTSHLCLALTSCYSGEDAFKPRNLLSKAFVSGSVSGGAGKGGGPDTISWHRLYCLSLDLFSSLLRSLGHGFLQHALDLVGVHQDRLLLALEMARVNLSQPVLAEAESSCNLLLQLCAFQRQWRFYLPEVMAKLLGALMAMLQTYVALLIRPRYLSHILEHKNLSGTGRAEMLVQPSSFLQHQTSMDDVEQPTSQLVEAEHSMLRLVGKALACLKHFTPSLPEIMLDQSLDVTEWDRVLGIGFGTPALESASEGVTFGTLLYCVTVCVRHLAKGEGGKLSPHRSSPDDPTRHQVPRPVIHFALENSLDILMSQACRYLRDPNLVPRDRQFLKRELGTELNSFLSSLHRQLRRGGGVERSTSLTPPNTGFSLSATSSAAAGLSSPAVGTPPVGSASTGHGSLTPQLNRSVSVTSFTGANDPAYIQLVQAFVQKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSE8</accession>
    <name>A0ABM0JSE8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 92</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100446.1">
        <property type="nucleotide sequence ID" value="XM_005100389.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858187"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040370">
        <property type="entry name" value="CCDC74A/CCDC74B/CCDC92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039496">
        <property type="entry name" value="CCDC92/74_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882:SF1">
        <property type="entry name" value="CCDC92 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14916">
        <property type="entry name" value="CCDC92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC92/74 N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100446.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="40243" checksum="1B184DEF5BE96C35" modified="2025-10-08" version="1">MSSESAMHQRNLESSILFMQQEHASILKGLHEEIALLQKRCTDLTFQLTMNGLTIDEPGTIDTQMQQVQQELESSRTKIQTLEKELSERDKRVERLEAEARTQRKRWLDESRAQSQTMNSLRAELEAKANNIAYLTTELHRLKQKGKAEQANDPSDNGKGTGYSANVQMGHSMGQGAMSQPGYLHRDSTLSAKNSLHPHHHMPTPPSKEKTLDPASASSRIRRSGHNRSVLSGGVSGKSLAPSHPSSADALLGRQHNPLRMSSGRSSGSESPDITPFLPPPKEEIVQVVGVKQAPILPPIPASSTSAVNVGSLSHPVLVHQVVSSTSQHRQKAKPSKTEASIVTLAVENAAVPEAARTVAHESRSSEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JT11</accession>
    <name>A0ABM0JT11_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prefoldin subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100817.1">
        <property type="nucleotide sequence ID" value="XM_005100760.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863907"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100817.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14547" checksum="9074D464BD19978B" modified="2025-10-08" version="1">MAATRQVIDPELSNAFAELSLKKAQSENQIRISNSQIENLTRKIQHSHLVEQEVKNLPSDVRLYKAVGRMFLLRSQDELKGELKEKQGSFAEKIKSLESSKEYLQRNIEECKNNVRELVMSKQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTJ0</accession>
    <name>A0ABM0JTJ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM204A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101135.1">
        <property type="nucleotide sequence ID" value="XM_005101078.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859792"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037690">
        <property type="entry name" value="FAM204A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14386">
        <property type="entry name" value="PROTEIN FAM204A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14386:SF2">
        <property type="entry name" value="PROTEIN FAM204A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101135.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23582" checksum="480B42F86673DFC7" modified="2025-10-08" version="1">MASSNSSLEKPKNVSSRLWEKFKSLEKRTDEVTKRSTEKRIKHLQKQVMDTVTQEFTSPEDKDILRKHDVKFGPPVETVAGKKRKTETNHEFTGTKEATATSSCDLLDYMNVNQHLHQTDHSRPPPPTALETKIDAAIKSGNLKEAEELSDRLAGREAGEKIVAAIDAKNFLEDKKVQDQMQKAKRKRKLNWGFEPKHRWETKGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTY4</accession>
    <name>A0ABM0JTY4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.17</ecNumber>
            <ecNumber evidence="9">6.1.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glutamate--tRNA(Gln) ligase EARS2, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101846219</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Gln) + L-glutamate + ATP = L-glutamyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:64612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:64613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Glx) + L-glutamate + ATP = L-glutamyl-tRNA(Glx) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9713"/>
            <dbReference type="Rhea" id="RHEA-COMP:9716"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:18398"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="2"/>
    <dbReference type="EC" id="6.1.1.24" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005101419.1">
        <property type="nucleotide sequence ID" value="XM_005101362.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846219"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 16 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="17">
        <location>
            <begin position="43"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="18">
        <location>
            <begin position="407"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005101419.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="61556" checksum="D7023AE214C539A6" modified="2025-10-08" version="1">MAAPLVVYQRLAFRFIGPETYRRKYRNLIFASVIQNCASSSGVRVRFAPSPTGFLHLGGLRTALYNYLFARSQNGSFVLRIEDTDRSRAVPGAVEKLQETLRWAEIEPDEGPAGGVYGPYIQSERLHIYHSNVKTLLRNGWAYPCFCTARRLELMKKEAARRGEPSKYDNRCRSLSQEKVQELMSKGTPYVIRLKLEPTPDPWDDMIKGPTSHNIADIEGDPILLKSDGFPTYHFANVVDDHFMGITHVLRGAEWLSSTPKHILLYKAFGWTPPKFGHLPLIVNPDGSKLSKRQDDVHVEHFRSAGYFPQAVLNYITSIGGGFGQRTQTMDLEEMCRTFNVEDVRRNAGRLDPSWLAVANRNILQERLDSNIPQVRTQLVQAVRDLVMETFGDRMCPGLLRDQILGEEYILGVVRWSLIDDRTTVLKDLVSPELSYLWVTPNPSTFDQLAEMGVEVASVLSLCLAWVKQREDFGMEALGVELKTFMKENKIKAKSFFPVIRMALTGLQQGAPLAEMISVIGRDSVILRLSTALSRLTSDRPSTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV28</accession>
    <name>A0ABM0JV28_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Craniofacial development protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101848366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102194.1">
        <property type="nucleotide sequence ID" value="XM_005102137.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848366"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF67">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102194.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28191" checksum="5D824E613186CAF1" modified="2025-10-08" version="1">MTQNKISIMGITDIRKKGTGTKEIHSNVVLIWSGVRKEQRAEHGVGFIIHPDNAKEILNTDFISERLIKISIREGKKTTSYIQVYAPCNDSYSDEEKDSFFEQLSDLISSIPDEEDLYVVGDFNGRVGERKTPWTKYLGPHSDNRTPSNHVLELCGEHDLFITNTFQHRASQMYTWYRWNNIKVSSQIDFILARSRMQITITDSRAIPNAGLDTDHRPIATTLTTKKERKPKKRQQERPNMHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVY9</accession>
    <name>A0ABM0JVY9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat-containing protein 53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102786.1">
        <property type="nucleotide sequence ID" value="XM_005102729.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860907"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042453">
        <property type="entry name" value="WDR53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="235"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102786.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="37494" checksum="8F588DF00B64E4EB" modified="2025-10-08" version="1">MATTKLTGGHTSSVLCVGTQRQSGQIVSGAEDGDLCLWSREGQVVTKVTRPDSECTSAIFSKDNPNIVYAAFGQEVLLLDITRAQEPIFVFQSNQEEVNQLALDSKEQFLAACDDSGEIKVYGLQDRKVFKTLRHKHTNICSAVSFRPGKQWEIVSGGLDCRLVHWDFSKPKCLNQFNMQELYATPGDSPHMINPPFVHHIASSPSGSTFACALENGQLPLLNASHKNLQPKHALFAHTQGVSQVQFLNEDNIVSAGNDSCIVHWDLSKAALYQPDAVVTNGDSHGATANPEEEKNLAITELCKVRSFSHPCKVNWMALSVTEAEQKLFVADQTPDISVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWB7</accession>
    <name>A0ABM0JWB7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101845481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101845481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103051.1">
        <property type="nucleotide sequence ID" value="XM_005102994.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845481"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045900628" evidence="2">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005103051.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12004" checksum="5BA796D9F264A0A0" modified="2025-10-08" version="1">MKTYMSVVLLAMSLVVIGAQVPEEAERGRLCFLCERVVQRLEQLLQESSPAQIDSGLDRLCDFAPGPLRPKCENLVQQRGSLLVQLLQHIPKDRLCVLICRSNNAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWG5</accession>
    <name>A0ABM0JWG5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lanosterol 14-alpha demethylase</fullName>
            <ecNumber evidence="7">1.14.14.154</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC101847052</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>24,25-dihydrolanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:45960"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:28113"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:78904"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:45961"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxy-24,25-dihydrolanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75079"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28113"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:87057"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:75080"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>32-hydroxy-24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxo-24,25-dihydrolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75087"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:87057"/>
            <dbReference type="ChEBI" id="CHEBI:87060"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:75088"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>32-oxo-24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75083"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:78904"/>
            <dbReference type="ChEBI" id="CHEBI:87060"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:75084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 21">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="7"/>
    <dbReference type="RefSeq" id="XP_005103142.1">
        <property type="nucleotide sequence ID" value="XM_005103085.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847052"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 21" id="KW-0349">Heme</keyword>
    <keyword evidence="4 21" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_005103142.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="55948" checksum="821D02A0EAB0E461" modified="2025-10-08" version="1">MFADAAFESIQESLGLADLSSGTVALVTTTLVLSAALAYKTLTGERVEGKIPPHIPSTIPFLGQAVSFGSSPIEFLLAAYEKYGPVFSFTMVGKTFTYLVGSESAALMFNSKNENLNAEDVYSRLVTPVFGKGVAYDVPNHIFLEQKKMLKTGLNIAHFREHVHIIEQETFDYFKRWGAKGTNDLFTALSELIILTASHCLHGKEIRSRLNEHVAQLYSDLDGGFTHLAWLLPGWLPFPSFRKRDRANLELKRIFGEAIQERRADPSPDDDMLQTLIDSTYKSGRGLTDDEISGMLLGLLMAGQHTSSTTSSWLGFFIAKDKELQKRLIEEQRLVCGEGLEPVDYDKLKEMQLLDRCLKETLRLRPPIMTMMRMCRTPQNLMGYTIPPGHQVCVSPTTNHRLPDTWKDFDKFMPDRFLDPEVANSEKFAYIPFGAGRHRCIGESFAYVQIKTIWSILIRKYEFDLVDGYFPTVNVSTMIHTPTNPVIQYKLRSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWJ8</accession>
    <name>A0ABM0JWJ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101860427</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103201.1">
        <property type="nucleotide sequence ID" value="XM_005103144.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860427"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103201.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37867" checksum="9233386FC2D9EB1D" modified="2025-10-08" version="1">MEADKAPRPCDPEKTLGRSFRFPILMSVDSKNHIHFRRNVAKNRKTWALMECGDGPGERCRHVICKGGGHVLNGRCIFERHFFFGVNTPFHMPANKRRVYNQARENMETPFNTRFIEFMKCALPYKWQPAEIHEFKRYEEGEETFPKTELVKAREIKNFERFIVKGVFPQTVSGYTHLFQEAVAFYLEYFDYASGYPELRYNSYSSNVKTPPPELESNFMDTNCSNSYNKNFSCSNGELPETTGFVQEGRNCSSTINLLQWSKTPSSCILYNTGLIAISYAQQIELRSVHSSATDFTFCVSGETSIASHEIFYFVFVFVLLAVKTCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWL4</accession>
    <name>A0ABM0JWL4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plant intracellular Ras-group-related LRR protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103230.2">
        <property type="nucleotide sequence ID" value="XM_005103173.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847511"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005103230.2"/>
        </source>
    </evidence>
    <sequence length="319" mass="36188" checksum="AFB128FF2EF053A3" modified="2025-10-08" version="1">MNKTLYELGAEIDLSYNKLTDLPTAKIKSPALRRLDVSHNQIAVIPDNIDKVYTLVYLNLSYNELEVIPRELGFLKYLHELDISHNRLTALPEEMCTQAYSLVILNASDNALTVLPVDIGKMKVMEDLNVGNNQIEMLPEEITDLKYLKKFDISGNKLTTVDVLSSLKAIEELRVAKNSITALPEDLHRLKQLITFDFSDNYIKAIPSTLNRIISLKDIVAANNKIDAIQDSLGKHQLLRTLDLTGNRTVSPTEQNWTPDNLDLNPLGFHHWGCLKYKIRGENLGKNPRLERNHHGEHKKREFSRAVANEAGVCSEQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXT4</accession>
    <name>A0ABM0JXT4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High mobility group protein B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104049.1">
        <property type="nucleotide sequence ID" value="XM_005103992.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861455"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21978">
        <property type="entry name" value="HMG-box_HMGB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF32">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="97"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="97"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005104049.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22580" checksum="31BA6DB81FD4A187" modified="2025-10-08" version="1">MGKKDDSKPRGRMSSYAFFVQTCREEHKKKHPNDTVVFTEFTKKCAEKWKEMTPKEKKRFEDMAERDKARYEREMSSYVPAGGQSKKRKRTKDPNAPKRALSAFFFFCAEERPAVRAAHPGIGVADVAKELGKKWEVCPNKPKFEELAIADKARYEREMQVYRGGGGASALPRASPKKAKTEDDDEDDDDDDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXY5</accession>
    <name>A0ABM0JXY5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101848372</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104170.1">
        <property type="nucleotide sequence ID" value="XM_005104113.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848372"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="37"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="313"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104170.1"/>
        </source>
    </evidence>
    <sequence length="892" mass="101370" checksum="D9A290573F3C3BD6" modified="2025-10-08" version="1">MSQVTDQLIDVISKPRARRTDAEIETAISWLRRRAQILNNVGKKELVEIVKNCSYETATRDDVIIQQGDYGDTMYIILRGVCLVYIDASLTGEEDPFQASSPPPQLPKDPAAAAGGAANGSPEPRKARSIDRSKYGKFIMRYESGKSFGEAALLCDDKSRNATVLADEDCDLLVLDQALFDKALRAEQELEYAEVCHFVENHPYFRHMSPKFKRLLELSLRKDTFPFDSVMTQQGMPVTSLIFILKGQANMYLEPHAYQKQYSHLWPFEAGVDLYSHEFEWLRESRRNNILRKYEDPAVWPTKSEHLVVKRTEGYAAAEKRVQDRTLCLCSIRGGEVIGDLEVVTKLSTYMFTVTSTSPTTAFVLDLKNLERLVGRRNQVTMEVMKETATEKLEMRAHSHYGKDVSFLSYLLYKIREERLPSAKKLPPIKSTKQLPPKEIQIQHLLEKFKSGEAQLVEPYVHGSLIYKEQMQEKARIRNNIRKRSPHSISGLLREARRKMNRRQPRSRREIVDSLKEMMESDLVEYSTDLPKDKPKATKKKPENPPAPSLTPARKMSNPSPREGAMSTERKGSLTKDPPKTVRFSNDTDKSSPRNINQMLTAPSNDSRGKPVSKPDSRRTSLLPAITETRETSALNGKVDGTRNGEKGMNSSFKSPRASDGDTSRLVSEAEEGPSSATSSKREYQRKEVSADSRSPTRLPPLAKPELKKPSPSSKWDMALRFVNERVNTELTKQLLSSNSGFDDYETSDVSLALLEKRIKSFFTEKVMSQTSTTMTTPRTSNTRRQSKDGDNQDLHLPPLRRFHVDLQDADVNIPKPGGKVWIRKRLCRFANSSIKVKDHEHVRYHMVPELPQFEDVKKARVVMHRILTASLSPEGMTKTTRNSISDVNTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0D9</accession>
    <name>A0ABM0K0D9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101864475</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101864475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aerolysin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105797.1">
        <property type="nucleotide sequence ID" value="XM_005105740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864475"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.412.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055267">
        <property type="entry name" value="Aerolysin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053280">
        <property type="entry name" value="Aerolysin-like_pore-former"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34007">
        <property type="entry name" value="AEROLYSIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34007:SF1">
        <property type="entry name" value="AEROLYSIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01117">
        <property type="entry name" value="Aerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aerolysin-like C-terminal" evidence="3">
        <location>
            <begin position="198"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105797.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="54375" checksum="22FC50FFC07885BB" modified="2025-10-08" version="1">MVVPLFPQSQRVFPLNDQRKTTVGGAELAPTMTNIPRAAFYFVFLHLFSIVHGGCKKADWYLGFDKIGSCKCSNPANDYIKGFERSPRGSPDEIFRIEYAFCCTAPNPYEKDHGQAYRADWKSSFEKNYTWNTCQTGFFLQGLYRTGKPELLENIESGWCAKPSSHPHHYGQCYVQDISDSFNDAGRQNKSNGRHKYDVSRLADYLGYGWYHDVSDTSVGEDFHRVGDTWSFDSGNRRLIMSFENWKLTLKSISYGEPVLQDLPPTIIGTGVVRNTLTAPIQHSVQRINEVARSVTHIPTSEWKNPEELNVKIRYIPEGLPASSGYDFTYETSSSTEDYHALNWTLTQYKTRRIVPYNATILIHFSTALKGFPRLRDLKGKEISPRFTSYSFGDGSEPFYKALKEQSEKQQGPWLWAEMRAQYGSSQAVINSLTSEERYDFTLTGKFEDVYSKKVEISWEQIFPEPERQSSLVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0F0</accession>
    <name>A0ABM0K0F0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101850589</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105824.3">
        <property type="nucleotide sequence ID" value="XM_005105767.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850589"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="364"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005105824.3"/>
        </source>
    </evidence>
    <sequence length="476" mass="52598" checksum="61B8D8A15F473D2E" modified="2025-10-08" version="1">MAPISEKEDRMGNLDGENNSEDADNLWADILTDVQSGSASKLPTTRSVLVLGDNESGKTTLIAKLQGLEEPKKGSGLEYYYIDVKDEYRDEQSRLNVWVLDGDPHHTGLLKYALKEDNFSDTLVMLVVSMAQPWSLLETLNKWAEVLSDHVDKLRIPAEKMQEYEQSLVRVYQGYTEPGDGPIATQGPPRGEVNPLHPPAASSEEEATLPLGELTLSRNLGIPIVVVVTKSDAISMLEKELDFKDEHLDFIQQHIRKFCLKYGAAMFYTSVKDERNCDLLYRYLVHRIYGFPFTSPALVVDKDSVFVPSGWDNEKKISILYEGLSSMKPEDAFEQVISKPPTRKVVQRDAEVSAEDEQVFLMKQQSQLAKQPAPGTSPAEQAAPRQQRPAVQRTPERSPAPANANTPTRGRDPATTEGMLANFFNSLLSSKAPGTPVGNKAAVTRDAAAELERMTRGKKNAPEATASPSTPKGPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1L1</accession>
    <name>A0ABM0K1L1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-seryl-tRNA(Sec) kinase isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106614.2">
        <property type="nucleotide sequence ID" value="XM_005106557.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855972"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052648">
        <property type="entry name" value="Ser-tRNA(Sec)_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873:SF0">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106614.2"/>
        </source>
    </evidence>
    <sequence length="369" mass="42853" checksum="DE7B8CE0564BC86D" modified="2025-10-08" version="1">MATPIVKVNKKLHTEQQNLGRKTNLCICVFCGIPGSGKSSLARVLCQNDSSRVHFHVEYDKVIPPFELDSRRNVKERRFFEIESECPQHNGDTDFSLWKMQRSQVTLLIEEFLNHVINLEDRPFSKPKEISEKMWTAFMEMVPAELDSLLRSGHELVLLIDDNMYLHSMRHEYFKMARKFSAGFCEIFMESDVSEALRRNKTRSVEHVPEETIIKMAAKLEPPDRHKFSWEDHILVAHACSQFEIEPVVQLIEKSIADPVQRLSESDEEEKATSRYECSVSTLHQIDLILRKCVTDLMVTSRNRQLPANELKELGKKASKVKEKIIQEFKRNNQEFLAAISEFNIQDAAKDSQSNLSKFMYELFHSELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2B5</accession>
    <name>A0ABM0K2B5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860686</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107072.2">
        <property type="nucleotide sequence ID" value="XM_005107015.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860686"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045821277" evidence="2">
        <location>
            <begin position="24"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107072.2"/>
        </source>
    </evidence>
    <sequence length="488" mass="54551" checksum="635B9FACBE1B2F9B" modified="2025-10-08" version="1">MSRHFSNMMFVISVLLLVSAVFSAPVEKAAQTSAAEVSKRSVAPQDEASHPDEDLQDLLSLVNKQASQQNTMVHKEKVTHFENNNGDLVKVDKEEEKVVDTNSGDVIADVKQEVKQQQASGSQQEPETVVETKIDIPSQDVHETFVQDDADGTAGDVDIRNAEDALPSNEDDSMEAELTPADMAEYLYATQQFEPFYAALDRLVNQSKMTVGEASSYAKAVAVEYERLQLQQLEDRLIFEEGPFGQLSSAADSYPPPEAAPYSVEDSYPPAEYQRPMGGYLRPEEEQMYLWQAEPRSYSPPPMDTADIDPYEFLAALWTEAYGKGNEEARDIVRMLYDRVSQDSNPDDMAQIRDILMETVDASVHDTPFNFDPEIMGLDELPPQQEGYQIPSLPEELLNTQLEDIPTAQKKNVIVEEADQQEDGEGEEEEVAEKNSPAQEVEESEAQASEDNSEEKEGKTEVKEETNVVGEAKEEKEAKTEIQETEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3M3</accession>
    <name>A0ABM0K3M3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101857979</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107986.2">
        <property type="nucleotide sequence ID" value="XM_005107929.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857979"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005107986.2"/>
        </source>
    </evidence>
    <sequence length="509" mass="55948" checksum="680A8C31CB332350" modified="2025-10-08" version="1">MSANLSPRHISRLFTIACVFSHLSPRYSLSLADGVTGPHKIIPQHYALAGEDVSFPCDVTGNVSSWIWTGPHLQAPPLVSSSTNQTSSSRVTYQRECVVSSNNISSPCLVLNIRHIRHGDAGVYNCQQKDSNLDLVTQGQRLVVVDPLPPPRQCHVLEVPQNTTVFVLCTTRTPLRHDIHYQLKAVPPPNAPETPLTTVKLLTSTTPDPIFSPTTFVTPLNPRNPLIRVTPDPPLTLTTPVTPKFFVTQTTTLTLVTPRHLWTTQGERLTTFLAQNDRPVFRLRKENLRGMLSNSDQTLYLVVCACHARLARASRCSSVILWDSRSWRFHDSDEQEGITLAVKVGIALSVCIGVLLAFGLCTLWAKCKSKGTQQVISGPTYHTGSESEGLTTSSRTTYTQPGGDGGERGHCYGGVVTSQMTLGGEAGMAAAGGHRDRKSSVVRREEEDVERGNVWRSTRAEEDVKRKTSKMSTGDQLCRVKCHLCRAAALFLRSRDVHTKANTTMTTMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4T9</accession>
    <name>A0ABM0K4T9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adenosine receptor A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101857831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108756.1">
        <property type="nucleotide sequence ID" value="XM_005108699.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857831"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="50"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005108756.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42986" checksum="EBFB6C190D47DC39" modified="2025-10-08" version="1">METDEDLSTQKLSSVIMALDPISTSYERPEAIIRIFLCVLVFYVPVIIVTNVLVIVTVYLVRKLHTPDNYVIAGLASADCLVGIWSLPLYILSDIPQTMPLIRSKRWTCAMRYIAFTVSQDSSLSILTLMCVDRFTSINWPFWYQMHVTNKAMLVAISVIYTAHTTKALVVYGLLMRFDETIEPLHNRCTVLNNAPHFYILQFCTAELGLQLSVSFCLCAQVSLTALREVRKLKREFHVLGISGTFRSKSYRSRMTNVKITVSLMFIFIILWLPTAFGGVMSKLVSRRVANIYRISTRLPRLANSFLNAVVYAFSKDTYRKAYWYLLTTPPYRWARLEEMMRSSEAFSSNMLASKLRKTTMDLASTSQRIVVGTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4Z6</accession>
    <name>A0ABM0K4Z6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protein vav</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101849884</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108891.2">
        <property type="nucleotide sequence ID" value="XM_005108834.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849884"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20810">
        <property type="entry name" value="C1_VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01223">
        <property type="entry name" value="PH_Vav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037832">
        <property type="entry name" value="PH_Vav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DH" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="78"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="263"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="376"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="480"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005108891.2"/>
        </source>
    </evidence>
    <sequence length="545" mass="62046" checksum="6BB1A6EAE20C3CAB" modified="2025-10-08" version="1">MQRVLKYHLLLKELIKTTDKSNHEREGLEQALEAMLDLSLYVNELKRDHEGLQVIEEIQNSINDLKMPANTSLKDYGRFQKDGELKVLSHMDTRPRNRHIFLFDRVMLMCKAKIVDKLFWGDTYSFKDAILLGEYKIDDSPVGADKKPEKGAQRGWSYPFLMVKQDKSNAFSFFAKTGDQRDKWKDSVALALDNSNPAAGRNFIMHTFDKPRECDVCGKLLRGMFYQGYLCADSQKAVHKECIGKPFQTSPPRRPPRTDKPQHVVTKARAEKGYRGNPSPPSRLKPPLYFAKDDVLEVLVKTDENWWKGRFRGEEGHFPASYVTERKGNLQRKDSYLHTANGAFAPPQSPGTGQMESSLGHRGSLANIANLNAFPWYSGEMERATAQKVLDPLPDGTFLIRVTKNPTRQGELSLSIKYANAVRHIKVNRGEGGFYLAAHRFFTTVQELVDFYQANELADSFPEVCTTLKYPYKKVATNARVHCFAVAIYDYAATSTSQVTLQVGDRVKVLSKTGEDKGWWKGENLRTNRIGYFPLAYVEEEDEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5H7</accession>
    <name>A0ABM0K5H7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CD209 antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101864181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109205.1">
        <property type="nucleotide sequence ID" value="XM_005109148.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864181"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="465"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005109205.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="66725" checksum="24D9EEF20AD5BAFE" modified="2025-10-08" version="1">MEMHNRSDETAENANCSNEDYRSDQLLGEKSKFFINKYKKLYILKWVCVIVAALLVSAAAVVVIVCTLRAEKAFSDMDAKLTEYITQCRVGEGKSGQRVVDTSRAKAERIVQNLELTTVRPDSVTPLNSEPENTLRSSQETTRLAGDGADFVKDFLLNFTDGINDRFVGVVRNLSSLERSTKKMHASLREVIVSVDDSKASVGERLSRLDTRIEEMGAALNVSSTMNSELKNVSMSVFDAVKKVKDSLDENKNTSTAQFFNLTDAVSKLVLVSNASSQAQSNKLSELFSGVSMLTNQTFVSSSKLQGVLDSVDTWIVELQTSLLNESASIKEEFRSEVLEKVRDSEKHSATVLLQSVDGLNETREKLQREYEQTVLSINLTISQLSESVLDWKDRDTTETDLDALVLSVLDQASTNISDGLLSLQQKFENMEETVSKVEEEITTQREVNLCSYRNGCELKSRASKKFQCYKVFQRIRLTWADARKKCLSLGGYLAEIHDHVSLEYVKRVVTIGSSRLWIGASDDGKEGTWTWVTSNKHLAVEDWHRNQPDNHKNSEHCMEINKGLAGKYWNDLPCHLKIGYICQKDGDDCEGWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6E5</accession>
    <name>A0ABM0K6E5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diamine acetyltransferase 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101849250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109827.2">
        <property type="nucleotide sequence ID" value="XM_005109770.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849250"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="60"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005109827.2"/>
        </source>
    </evidence>
    <sequence length="214" mass="24690" checksum="0A52BD8463AB0F58" modified="2025-10-08" version="1">MLIMIYLVLSVKPERADLILFSSLNYPSSSRNGVFTFALLNTIMANNPSATMLNAVKKSSDFFRYNSELAEFEKMADQVHITTDTLRKDMFAEKPLCSSIVAELAGSEPRQLIGYSLFYPIYSTWDGVSMYLEDLYVTPSQRGQGLGKKIWQHVTKAALDLNCQRLHLAVLNWNTFAKDFYLRCGLIDLTETEDWHLMRMRRKEMENFVKDLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6N1</accession>
    <name>A0ABM0K6N1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fas-binding factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109995.2">
        <property type="nucleotide sequence ID" value="XM_005109938.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850369"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033561">
        <property type="entry name" value="FBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049390">
        <property type="entry name" value="FBF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33689">
        <property type="entry name" value="FAS-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33689:SF1">
        <property type="entry name" value="FAS-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21007">
        <property type="entry name" value="FBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fas-binding factor 1 C-terminal" evidence="3">
        <location>
            <begin position="839"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="749"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="872"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109995.2"/>
        </source>
    </evidence>
    <sequence length="1390" mass="154024" checksum="0C32A784DB7FB0A1" modified="2025-10-08" version="1">MDSLSGKKKSRKDSDGLDDLLGDLLAEDTPSKKRSTPTTPTRQRSGSGKGGKPGGKDENFYSSLAAMADSDGGSDISEADVNQVAHSIGGLDDMDADLFGGSLTKKNNNSRSGLPTTPRKNSRKSPRSPTRSETPTSPPGSARGSLKKKPVKPPSPAPSPVSSNAMSLPQTHPEFKPGTAPGKMTDMSSASENLKPNQPISQRPETAPKVKKKYDFGDFDPDDPLAGVLSSDGDDDISERDRPRSSTKRPAAAPLAQSKPAENALKSDSRQDSPRRRNNLMERPPTRSGSNAGDGASARNGLSGAGDAGVKKSQGNVFSDSDGDLLDGMGLDEEKPAGNNRRAEVTYKAKPGGDSEDLRPARSVFDSLLGKGTGSAAQLLEPKEKKQFVLDTKYTSSNAGSGDIKGTDEDDFHFGSYQPSAATGSRPSSRRSVRFQDDDDIFGLDTRPSPRAKSPGSRPKPPPDMDWLETEASKPPAQTSAASPVKPSGQASSVASKPPTPNKADSASKPPESPRKTANKDSLAPSTPVSNTAPSPRAWLGLEDSDSDGEEMFKPKRSAARVATLPQSPVVSASPSPRIPPKKLGKKEPASPKVSTPTGNNNNDDDDDWLARARSRRQQMLSKDENKDKSSKSASGGEGGEDLTGREPDLQGQSMRMDLSSLIGDSPKLGGSNQISSDLFSTPQGRAPGPPAWESPGSAISQTAGGDKLSASLTPQWQAGGLDPRMASSGTTFGQNQPIAGGSAVGQSIVQLQQQQQQQQLAQQQQQQQFLQQLQQQQKSELLQQQQQLEQMLQNIRSQHASMSQVTAPSISVPSYSQITASIELPDSLQEAHARLRKLELEKHYMESMLDGMRKRFEEEMVAVETSYKNRMQIIEDSNRKKEARLREENEALMEQHVGRVRQLEQEKSEVSSGHYRKLEEVERDRAQDLEKLREQHRLAVQTLKREHEEALDRLASAKNQEITMVANANDTSRSLTAVVEQIQNNARDLGELHLKVESWNRQGLDEREISLRSKDEQLRMLQERLTRQEEDNDRERKRLEDLIARMETQLRDQTRSLEEERWKLKQDQSRAEAQQRALEEERRLWLEQQARERITVERARENYLEEQRTAMGQISEERRLLVEERTKFQAEQKTVREKLHHDSMKRSQAEADYEVLIRTISEEKAQHSSRMQELQREEDRLATEKSKVEREKNILDQEREKLADQAHQIRQQSAQIDHMTEAASRTRMEGDQAMEEAMHINSQIERRETEVMKQQSAVKLMEERISQEKLRLAKEKKEVENLKNSSLCVNCRSPVNGPAVYPPFQQNGYHTPQLMNSVGMSPVQSVRLSSSLQQPVGNPLDNIASSIANDRAVRMWKINAIKDKEFLEEESLYLETLRHTPYHSTASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K935</accession>
    <name>A0ABM0K935_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="5">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC101853749</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005111811.2">
        <property type="nucleotide sequence ID" value="XM_005111754.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853749"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23532">
        <property type="entry name" value="TFP_LU_ECD_BMPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF68">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="21">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="232"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_005111811.2"/>
        </source>
    </evidence>
    <sequence length="531" mass="60094" checksum="D3F1A31037F42C66" modified="2025-10-08" version="1">MTTLVWGLRTLKMADLRIMGSKIYTLWGTLLILLYFCYSGTEAVRCHCHPCYNSDTNGTCETLPGGACYASKSLTPLTDWEDLETRTWGCLAPEGGTLLQCQPSAVPHREVSACCKNEDLCNLNLNLTFSEEDFLPGVVHPSDPEKRAENVTQIVLLISVTVFLLILIVAITIVYLRFKRQEFRRKQLLVDSEHETFVPVGQTLHSLIDESQSSGSGSGLPLIVQRTIAKQITLVRSIGKGRFGEVWKAKWRGENVAVKIFFTTEEQSWFRETELYQTVLLRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLRLHALDTSEMLYLAHSAACGISHLHVEIFGTRGKPAIAHRDVKSKNILVRKNGTCCIADLGLAVKYVSENNEVDLASNTRCGTKRYMAPEVLEETLNKNHFDSYKQADMYAFGLVLWEIARRCVIRGFVQEAELPYYEYVGQDPGIEDMRKIVSVEKLRPTIPAVWEEQEYLKVMGRLMCECWHPSPAARLTCLRIKKTLSKMIETIESAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K961</accession>
    <name>A0ABM0K961_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Uncharacterized protein LOC101863557</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC101863557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the milton family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111853.1">
        <property type="nucleotide sequence ID" value="XM_005111796.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829203.1">
        <property type="nucleotide sequence ID" value="XM_035973310.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863557"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006933">
        <property type="entry name" value="HAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051946">
        <property type="entry name" value="Intracell_Traff-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022154">
        <property type="entry name" value="TRAK1/2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751:SF12">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN MILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04849">
        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12448">
        <property type="entry name" value="Milton"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01424">
        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01423">
        <property type="entry name" value="Milton"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAP1 N-terminal" evidence="8">
        <location>
            <begin position="176"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking kinesin-binding protein C-terminal" evidence="7">
        <location>
            <begin position="949"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1255"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="692"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="784"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1090"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1260"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005111853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035829203.1"/>
        </source>
    </evidence>
    <sequence length="1486" mass="160719" checksum="9D5B25CA78E0EF17" modified="2025-10-08" version="1">MPRSVRQSHSGPVLNVPNTDEDVSNNNVLSSYHQQHDIMALGGNSTSDAMHVDSDVHGSLLDNSNFLDNSGLHLVSPLIDNEEGSEGGLHPHPWDKSANPLKNLLGRSPSSRDFRTQCSSDDPAFQDFAANIHKSSSSHNFLERSGQVGHLSLHAELEQAERQVGESSAGSSRCLREQLSMPDRKEVFRDASESLSTPESGSAKETTVLGHFKTKSVSNLLAHAHATAKHSVEAVVRKASSHADLRRAAFSSGRPCLSVEVPGVVSSAGQHPAPSGFDIMKKSSSSIDLGSIHFDNLEPVSVSDLYRRRQVNSPHGDATDITDAAGVRTPKNHLNTDSGNVAPNSSSPCGKLLYVSGLARSESSLPQLSNLNDYWSDTSSSCTTPRAHTPGTSPQWLTPSTTPMPSPRHSAFSCPGSPNPTYNINQTPDASPSQSPRRSFDNGTSSADHGSVLSFHFDNRGSSSRERRISETTEMTDSDADSSTTLPHCMSSDSSDASMEAQAETEDFGIPGSNSSDAGDYVNYGAGENLSDASVSGVGGPPCYAHDNENVECDGGEGCEDREFDCSEGGVIPGVLDYHQELADSQEEADSSPFPQDASYAHDSDVMSGAESEFASDSQPRSRATSVSFASLFKQCRVERDSHPVDLHMHGGSTQDGEDEELSEATEMVVTDVWDFLCAERVSQMTKTYNDIEAVTRLLEEKERDLELAARIGQTLLSKNKDLSSRTETLEEQLVNANDKVSQLRHDLSMKDELLRIYNEDLELENNGHTTPTNDSKGLSLPNVDFLQKKVHTLEDENLNLRLESAQLKADTDSYEEKEKKLVEDCIQQIAELNQQVESLAEELHAKAEENGHQKEEITGFLSQITDLQKKMRKLTLENMDLHEKLTASTESQRRLTKELGSMQDKYDELFEMLEEAQDELRVLRGRHKIRASGKHHHSAYAVPTDSLASELETSLKQELSQSNRRAQSWKIFETAKAAKRAAAKAAEKEVMSSVRMSVMAVPSSTRGDSDTMSQGLSAYPSDVESFASDGYSGDMDSLYGSNPELGRPGIPGSNDLESALKRLAIRRANELNEKDFQEEEEERRRQQQVMNMSGATSPNNITSPGSTYSYMSSNTGTPSGGQGGYKMSDKLQIVKPMEGSMTLRHWQHLATPHLGGIFEPREGVQMKGERKLELQEEVYSLSDFEEDDPRDVHTRKEQDSGLVYTFTDSTVPTMGPYRGLGSLFDNSRASSTTSLINASFTTDELPVQASTPKPVYKEQNNQQQQHQQASVQTVNSQGTSMSLGLASLLQGRENTGVGRAILRATSAGQKAAVAMEMSASPVIATQSVASGSVRNQSGFLMSQSLSNLSSSAPSSKSRNLPGSKSFEQVLQEPQEKVKVTVAVGEESKQASMFTPGMTGQGFLQQLKNKGYSLYGLWGGGGKGEGASSDPAAEGASGVDSKGLAAVEGNPAVTKPSAESVFANGSGGGGVGVLGALTNFRRNGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9P1</accession>
    <name>A0ABM0K9P1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sorting nexin-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101861705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112274.2">
        <property type="nucleotide sequence ID" value="XM_005112217.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861705"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052467">
        <property type="entry name" value="Sorting_nexin_PX-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15813:SF9">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15813">
        <property type="entry name" value="SORTING NEXIN-22 AND 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005112274.2"/>
        </source>
    </evidence>
    <sequence length="163" mass="19017" checksum="1B6493A8661D24ED" modified="2025-10-08" version="1">MVLRVNIPSFRKVKEDDEMYTVFLVDVWLSGHHQVIEKRYSEFEELHKQLKKIMKTPEFPPKKVLKWNTKVLEQRRVGLDAFFQGVLEHEPTPSIVHTFLETDALDASMDFENEEEQKTTHQPVVTLDADVFLRNLKTNCLPNIIEEGVKMGLYSTPSPNFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9Q8</accession>
    <name>A0ABM0K9Q8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynein heavy chain 10, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112302.2">
        <property type="nucleotide sequence ID" value="XM_005112245.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848630"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="3">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="2">
        <location>
            <begin position="143"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005112302.2"/>
        </source>
    </evidence>
    <sequence length="277" mass="32063" checksum="ECD2B7403405A8E6" modified="2025-10-08" version="1">MMLYAQIVKELPPTPSKFHYIFNLRDLSRIYNGMCLTTPDKFQKPDQFLRLWRNECMRVISDRLITTQDKTLIQDILKSLLKENFKDCDLESITRDPSLFGDFRMALDEEEPRIYEDLQDYEATKALFQEILEDYNENNQPPMRLVLFDDALEHLTRVHRVLRMDRGNSLLVGVGGSGKQSLCHLASYTAGCTVFQIMLSRGYNESSFRDDLKVLYNKLGMENKQMVFLFTDQHVAEEGFLELINNMLTTGMVPALYADDEKEGIIGSCGVLDELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA52</accession>
    <name>A0ABM0KA52_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101845821</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112613.1">
        <property type="nucleotide sequence ID" value="XM_005112556.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845821"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005112613.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="20303" checksum="9C40230705FB879D" modified="2025-10-08" version="1">MKISVTEWTLFFISWILCFTGGAILRPYRQNVLARAKMRPTTFGPRDPRRFKMQSLATIGFQPTPRRCCHIGERVAKKKKICDITVLAVVRKYERDKYSPVVSNRSAKHFKRSRLSKLSEKVSKCSAVYPNHFVKCCKYKKEFYNHLRKCHTKPRRQRRRCKKNVRRRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBF4</accession>
    <name>A0ABM0KBF4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101850536</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113541.1">
        <property type="nucleotide sequence ID" value="XM_005113484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850536"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="41"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005113541.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22180" checksum="59014ABAC09E3F41" modified="2025-10-08" version="1">MSNSSNHQISFEQPNSSHGIYFIRHIVNFLSLAVAMAGVAGNVINIVVFTCQGFKSSINIAFLALSVSDLVTLVVLIFYIFVAWFEDTTSLPILPRHTWHLVGWLLYALAFNNCSIAVYISVERCLSVALPLKVKAIITRKVTVFSVVLIGSASAVIVLPALTAFELKRMTSDDNATDVAIIVLDNFTHRTVTYFAHFVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUW3</accession>
    <name>A0ABM0ZUW3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polycystic kidney disease protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC106011096</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934947.1">
        <property type="nucleotide sequence ID" value="XM_013079493.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011096"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="880"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="11">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012934947.1"/>
        </source>
    </evidence>
    <sequence length="1089" mass="124752" checksum="5C0A62F76EFF87AA" modified="2025-10-08" version="1">MRRNAGTNSRVFFILSGEEDETEVRMLSDTKRPILKRGMTNGFLMAVPESLGRINYMRVWHDNSGNGKFRSWFLNYIVVKDLQAETKQVFIANRWFAVEEDDGQVDRIIPLAGKEQLEDFSYQFKERSKKDLVDGHLWFSVIARPPGSRFSCVERVACCLCLLFMTMLANAMFYNVDTGDTSSASSSFNFGPFSMSPSQISIGFISTLIVFPVNFLLVFLFRKSRPRTIPESRIVLGRPVSGHRPGTAKLSQVKPEISCVSSPRLESSAGRSSPGSDSNSSLNKTRDNERLVKGSHPSASQGPPSPPDGTGEQGAVKKKLQLPWWCRPLAWVILVVTTAVAVAIVTFYGISFQDSTCKKWITSLIISFFTSVFITQPIKVILTAVFLSLIVKNPGEEDDEDVDERNTVNTDDDFLHPGGDAFAAARPKTIGYKPPNPKELERVRSKRIKEVKMWAVVREILFYCIFLWVLLVVSYRNRSAAHFHYKDTMVRTFIKSRDTDINFEKIQNTDEFWEWAKTGLINGLLAGSYYNNYPPLRLRAYINDKASRILGHAVMRQHRILPGGCQVPSYFKTMIPQCNTLYSLANQEDRNFEVGWERSPASKENPSNRSEYEWTSAETLNGYPYWGLLGVYSGGGYVAHLNGSKAAVLETVSRLEREKWVDRYTRTVFVEFTVYNPQVNLFSVNTFLAEFHSTNGVVPSYRFEPAMLLPYMNDAMVFQIVCEIAFVVFIVAFSFREVSKFLKHGRKYFTKFWNWVEIVIIAMSVAAIVIYFYRLHETNKLTKQFKASQGNDYIKFQYVGYWNEIFAYLIGIVVCFATIKFLRLLRFNRRVSMLSSTLRHSARNLFHFSIIFWIVFLAFCQLFFLTYMTVDEKYSSFIESLVASVLMMMGKFNIYVMILAEPVLTQIFVLLYVVSVTFIIVNMFISILNDTFTTVRNDLTKQNNEYEILEFMMSRFKKWTGLGVTPSTLNPRTTMGVQGYLNDDMNSDLEVEESEGPGSEKQRYLRDINRRMSLHMQHFPGRIDKLLQSLSALYRDNEDGSAGLPQPWTKHPYMAPSAPSDRRSRMPPLPRSDSGMSHRRVSLVKVDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUY2</accession>
    <name>A0ABM0ZUY2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine-rich cell wall structural protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934969.2">
        <property type="nucleotide sequence ID" value="XM_013079515.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849437"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012934969.2"/>
        </source>
    </evidence>
    <sequence length="158" mass="14213" checksum="EE84C8880331A826" modified="2025-10-08" version="1">MSGGMSGGMSGGMSGGMSGTGAPALSGGMSGGMSGGMSGGMSGGMSGDQDITDLKRVLSSYLKKRGDGPTGGTPHSGGMSGGSGGMSGGAGGMSGGSGGMSGGAGGMSGGAGGMSGGAGGMSGGSGGMSGGPSPQGGDEMSRLIRNLRLVLKNAKRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV67</accession>
    <name>A0ABM0ZV67_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein ABHD15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935130.1">
        <property type="nucleotide sequence ID" value="XM_013079676.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860959"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF93">
        <property type="entry name" value="SERINE AMINOPEPTIDASE S33 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012935130.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="59404" checksum="4434BCF954D4B4DF" modified="2025-10-08" version="1">MPLEVTYFFSVLPFPLFVALLGSVLLSVGVFLKNIFNMAPTELPGLYYRESPLNAHVLAKCKLKERQFSPCPWLGHRHVQTLLPAILPKPDVTFEREYLQMRDKGVVALDWVVCPQAKPKKRRATVLLVLPALTDGALSVTGICHTASGRGMRVVVFNRRGHGGSVLTTPRLQSFGDPSDLRQVVKYIRQRLPKAPVAAVAYGTGCGLLMSYLGEFGSSALLTVGACISPCYDVPLRFSSAISNLYDLVLLVRLKTLLFRHAKALSTVLEVDKAVSAWNFSDLDLSLFCPLYGYQDVEQFWEMNNPIRDVDDIEVPLLCINSLDDPTCQCADIPFDLFKCYPNFLLAVTSKGGHCGFLEGFPPKSWADSLCLDYAEAVVEFTAKSTQQQQQQQQKEQQQLQVKVNESSAAALMAEDAPLSPHSGRGPASPTSRKRSSSTAGQPAEPTDPVVQPSPTKRIPTGGSSSANATEPAPSSSIHIGGPDICTESFKSYRVRGNIRSSSESDTTDELSSGDESLSDPSSETSSNHSPCGEYMDLSVDRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVG1</accession>
    <name>A0ABM0ZVG1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC101854071</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101854071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935328.2">
        <property type="nucleotide sequence ID" value="XM_013079874.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854071"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009454">
        <property type="entry name" value="Lipid_transpt_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06448">
        <property type="entry name" value="DUF1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0758">Storage protein</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045982687" evidence="10">
        <location>
            <begin position="18"/>
            <end position="4332"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012935328.2"/>
        </source>
    </evidence>
    <sequence length="4332" mass="479534" checksum="715517F54A160A07" modified="2025-10-08" version="1">[encoded data, 4332 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVV9</accession>
    <name>A0ABM0ZVV9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935618.1">
        <property type="nucleotide sequence ID" value="XM_013080164.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011240"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047511824" evidence="1">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935618.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15253" checksum="49A2FBBAAB6F0302" modified="2025-10-08" version="1">MKTQLMTALCALLATCSLGQNVCDPMDSGPFLGTLPALDFTVMEPIGTDTLSQDCSTDAKFRSPLRLVGGPNQFTLTVENFPFINPFDYFSLVNCGGTHYLQLKQAIDRDGPTSSLEDDLSFMSATLACTPTGGTKVVSSSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWF9</accession>
    <name>A0ABM0ZWF9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox protein PKNOX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935934.1">
        <property type="nucleotide sequence ID" value="XM_013080480.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854704"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="187"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012935934.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28958" checksum="5C9D8D7935A2F374" modified="2025-10-08" version="1">MDEGNSAYRSHPLFPLLRDLVIAEMNFDNPRFHYQQLLSLLPNDFEKLLQNFLHRNPPSGHYQSNQAVESVIMDSLRLAHSNLVDKIRHRQELEKMKANSSASLRSMEEFCQKFDHSVTGPMQGRPGVPNGVGPMGMAHHHPMAGYHEGGYIQTGMGHMGQFRLKDGPDLLGETTLTSASPQANKTESKKHPSLPKEAVAMMMEWLRNHKDNPYPNDDEKAMLIKQTGLSINQINYWFTNARRRILPKWAQCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWK5</accession>
    <name>A0ABM0ZWK5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935999.1">
        <property type="nucleotide sequence ID" value="XM_013080545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858701"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012935999.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35345" checksum="E14532E0C8C81978" modified="2025-10-08" version="1">MSQEQMTLRGTLQGHGGWVTQIATNPQYPDTILSASRDKSLILWKLTRDETNYGVPFKSLHGHGHFVSDVVLSSDGQFALSSSWDKTLRLWDLVEGKTTRRFVGHEKDVLSVAFSADNRQIVSASRDKSIKLWNTLGVCKYTVQEDTHKEWVSCVRFSPNASNPIIVSCGWDRVVKVWNLTNCKLKTNHYGHTQFLNCVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDAINAMCFSPNRYWLCAATGPSIKIWDLEGKVIVDELKPDVMAAGAGREPPQCLSLAWSSDGQTLFAGYSDKLIRVWQVSMAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWY3</accession>
    <name>A0ABM0ZWY3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101847574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936207.1">
        <property type="nucleotide sequence ID" value="XM_013080753.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847574"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012936207.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="55575" checksum="BE07D87B1D748327" modified="2025-10-08" version="1">MSEGAMCCVPARHRQKMWVRVLMDNLLIILIVIAVGAGVGMGIGLREVWTHEDVRKIWYLGFPGRLLLNMLKMLILPLVVSSLITGMASISNSASGKLGGAAVLYYMVTTLLAVIVGIILVMSIGPGENTGKLRRAGKSTKAEPLDSLLDLISQCFPDNLVTASFQRRVTEIETKTFLYDNDTRSVTVDSPYLVSKSGTNVLGIVVFSIALGCVINNLGPQGEPLKAFFDSLNSATMVLVKIVIWYTPIGILFLIAGKFVETEDIGKVLSDLGLYMATVLAGLAIHGFVVLPLLFLVATRKNPFKFALNMSKALFTAWGTASSSATLPITMDCLVNKNEVNINVVRFVAPVGATINMDGTALYEAVACIFIAQVNNYDLSAADIIIISLTATAAAIGAAGVPQAGLVTMVIVLTAVGLPTEDVTLILAIDWFLDRFRTAINVWGDSVGAGILNHVFRRLFREQEQNAIELMVDSPDFNSNNSVSKTNEKEEDDDRPPSYNGVTNQAFEDTPNTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXZ8</accession>
    <name>A0ABM0ZXZ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamate receptor ionotropic, kainate 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106011477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012936808.1">
        <property type="nucleotide sequence ID" value="XM_013081354.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011477"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046098595" evidence="5">
        <location>
            <begin position="25"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="45"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012936808.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35760" checksum="888BA796B76FCA06" modified="2025-10-08" version="1">MTSTHWKRLSTLVIGLALVHCARCLPELLKIGGLFGDGDEDPSIENAFRYAVYRINHNRKLLADTKLTYDIQSLPINDGFAASKKVCYQIEQNTIAVFGPRATNLAGFVTSLCASLQVPHIEIRSDALDSLYTPAHALTVNLYPGMEQLGRAYTDVITYYGWTEVLVIYGVRHGLNRVHKVLRGDFRTRAEILVRFVEPDTMRAVLKEAKEKKWRRMLVDLPVDDTTIFMKMALQEGMIDPYHHYIITNLDVESIDMEDFRHNYVNLTGFRLVDPGDPQVRKIIHDMEIYEMQTDLSLLNTTGYLSIPVNGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYA3</accession>
    <name>A0ABM0ZYA3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium channel subfamily T member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101851798</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012937020.1">
        <property type="nucleotide sequence ID" value="XM_013081566.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851798"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="14">
        <location>
            <begin position="327"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1009"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1140"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1011"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1161"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1225"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1244"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012937020.1"/>
        </source>
    </evidence>
    <sequence length="1261" mass="142716" checksum="5C9D0759AD1EFF71" modified="2025-10-08" version="1">MTDDDDIGDGDCDGIDFKWMRNDSDSESEEEDWTEREGTLPKFPTRELSLRARLRRILLRNPTTRINISVVYISLKVLLCCLYVVRVCLDDVKQYACHGGPCNGTVEEDTDEGFTSTNINWHVLLWVNRPLPLWVVQILLSAITFFKSTLLVLITMKGNVFLKLTSRDYVLEVLCSLPMVVSVSLWTPQFLNCWLALISLKRLLNDFHLARQRFQTMSVTLYQQSWFLIATLGCLIFTTICGIQHIQRGSHKKPLNMFEAVYFVIVTLSTVGYGDISPDIWLGQLFMLFMICVAFSFIPRQLEEIGSTWSQRKKMGGDFRRKASAKSKHVVVIGTEFTTESVMNFLNEFFEHPKLEFYTVILMSSEELDDNMQFILKDPKWANRVLYIRGSALKDIDLKRCRIHEAEACFFLINKSSDEVEKADQHTVLRSWAVKDFAPHCAQYIQLYKASNKIHVKFAEHVVSEDEFKFALLANNCLYPGLSTLVTLLLHTSRGHEGSWAPETWQQIYGLHSGNEIYHIQLHRSIFFREYEGKKFTYASLDAHQKYGVNLIAVLDTTAVDAQLQLNPGSDYVMRGTDYCFYMSLTREEYMKAIPKALEATKSASEVRNKNIAIIVKEMNKLMEAHEADQEEIDEESVFSTITSNIGSNLGKSLKLGLEALPLLEKENARFSSTDSGGGNMSERVESFDRVQGATNYPSKIVQQMIDFDQESFTIGPPPSTLNLGTRRTLCHLHKDSRSLCCLEWGKPCEHCQYKVASDKRWDHQLVILSVRRSCPGLYNFIIPLRSKYLSLLSLSPIILMFQEVPSRFFLETIAHFPLVFWMQGTVNNLDDLLTAGVNKAMHLVISHMEAGPGGEENLHDAATIVTVQKISRLFPHVNIITEVNEASNMRFMHFKAKDSYMLKIRKLEKRLKERAVTNLPYMFRLPFAAGQVFSSGMLDRLLYQTFVKGYLISFVRLLLGIDAEKNSGHLSSVRIRRATLSQFPTYGDLYQGLCSTTGEIPIAIFRTDKQSSSSEGELPTESNGNNNIKPEKLSGLRDSLRHGFHLPHSHLHSQRQGLRSSRMSVGAGFFERDKHSNQHLEEMVQARMESLQLADDDEPYVISKPPKALSYVIVNPTPKRKLRNGDMVYVIQPSSMQAVPNKLNRSGRSPAKSFRSRHISVNVSGVGTSKSSSTPTSTPSPRDNPAPKSYDEKSQQPSPVELHGSLAGFREGSPAAPNGTTVVDFEKEDSVVEMRPRCKSESSAKQANSSDSNGGKPVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYT9</accession>
    <name>A0ABM0ZYT9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101846811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012937340.1">
        <property type="nucleotide sequence ID" value="XM_013081886.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846811"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012937340.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="32083" checksum="80873AD306A12279" modified="2025-10-08" version="1">MANVGRIFSSFARSVVLQSCRADGNVPRIACQRLYSSAEYENIKVEKRGEKQNVLLIQLNRPKALNALCDALISDVSAALDIAEADKDIGAIVITGSDRAFAAGADIKDMQQFDSFAEVFNSNFLESWDRVARSKKPVLAAVNGFALGGGCELAMMCDIIYAGEKAQFGQPEIALGTIPGAGGTQRLTRAVGKSKAMEMVLTGNRISAAEAEKAGLVSKVVPVDQLVDETVKTAEKIASYSKTIVAMCKEAVNAGFNMPLNEGLSLEKRYFHATFSTNDRKEGMTAFVEKRAADFKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYZ7</accession>
    <name>A0ABM0ZYZ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell death abnormality protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101846348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937436.2">
        <property type="nucleotide sequence ID" value="XM_013081982.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846348"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012937436.2"/>
        </source>
    </evidence>
    <sequence length="515" mass="55598" checksum="4F0D4BA2B8EF1B10" modified="2025-10-08" version="1">MPSTELQFNETCRPDDECAENLQCDNETGTCLCLPSLYYNGSSCVEKGQYRDSCDPNTADQCAQGLECSVMDSFCECPFSDYYNGSRCVLKIQFNETCTENAVCTENLQCDDLTSKCLCNSSLYYNDSLCVERIGYNQGCTTVDSCAEDLKCIDFFCKCQHTQYYSGSNKCLPKKGYDEQCTWGSPGSENQCAGKLTCDVNSWCKCSSGQYHTGSNQCAPKISYNGTCQLGPENQCAGQLTCDANSRCKCSSGQYHSGFDQCTPKTGYDGQCTSVSQGSENQCAGQLTCVNFACKCFSGLYHTGSNQCAPKSDYDGYCTSGSPESENPCDGQLTCVTSRCKCSSGLYHTGGNQCALKISYNEQCTSGSPGSENQCAGDLSCVNFACKCSDMEYHYGNDRCATKKGYDEQCSSVSQVSENQCAGQLTCDANSRCKCSSGLYHTGSNQCAPKIGYDGQCRFVYENPCAGQLTCDVTSRCKCFSGQYHSGNNLCAPRLAHGAGCANLEDPCQSGLSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0B7</accession>
    <name>A0ABM1A0B7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 and PX domain-containing protein 2A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938230.1">
        <property type="nucleotide sequence ID" value="XM_013082776.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859409"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF26">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="168"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="241"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="390"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="880"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="710"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="780"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="842"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012938230.1"/>
        </source>
    </evidence>
    <sequence length="936" mass="100925" checksum="F474728399EE6224" modified="2025-10-08" version="1">MGRKISEIEVLDAEKRRAPSKHYVYVILVTWADGSSLTVFRRYSRFFDLQTKLLDLFPVEGGIIDPQKRVIPFLPGKIFFGRSHVKDVAMKRMKDISEYCKSLIKLPSHISECEDVLEFFEVEPEDLDPPSANPEDGKRKLSLSLSLNSLSKSKSSKEKKAEKISKPKRLARYVAVAEYTVQASGEIALQPGMTVEVLEKSDSGWWFVNSEDEQGWAPSTYLEPESDTEDKSEEVMRAKPGSEEKYLCIEDFTAAGADEISLEKGAVVEVVEKSMDGWWLVSYQGRVAYAPGTYLKKATNAQSKNLADQARLSGVQIISSLQDVSNLLNKEETKASNSQSPSNNQASSDVVKKPVASAVVKQRSLERGGSLNPPPRQNSITKIASPTSQSKSNIYVTIEAFEDTVGDGLSFKQGEKVYVKEKTTSGWWFVALGQEEGWVPSSYLESCTDDLRSSSVYELASSDEHGDPAEQSDDSDDSDKDYDADEDWYVTPDSDLGRESQAGPIVIPTTSPDLRGKRPLPPIPPEEDQEEENKPAAQPKRFAARPLPPPPAPPVESESKADTPALPPSVPTVKPSLPAVKPNVPKAPYNTVAKATSGKPKPQLPDPASQAKPGGGGSGGGDLASVLKSKFEARARAAASSDEELEENKKSSPSVPTTKPTPSAGKVFPPALPSKPSDLRKSPRESSPQSSRPNIGSNKGFSKPPPPAKSKPTSAAASNSSATVDKPSVPLVPLKPVGKPELGKPEQSGNGTSNQDKNQGVSKEKPNVKAMTGLFNKPANPKPSPAGKPQPAVKPKPGVAVKPSIASKPSGQSSKPNGQWNKPSGQAQVNNLANSLSSKLNFGQSPASDVNQNNPKLKPKPEVAEKLPSSAPPSAPKPSSQGQVCVAVYDFTAENSGEISFCEGDELEILDEQDDWSLVRFYDDEGWAPTGYLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0P4</accession>
    <name>A0ABM1A0P4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101864462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938444.1">
        <property type="nucleotide sequence ID" value="XM_013082990.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864462"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF176">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045004611" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="19"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="618"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012938444.1"/>
        </source>
    </evidence>
    <sequence length="657" mass="75135" checksum="352B14290119662D" modified="2025-10-08" version="1">MFALAAILLVSSIGGLNAFYLPGLASVTYCSEEKENNNCQKSLKVYVNRLNTVENIVPYEYHHFDFCVPDKDVANSPTENLGQVVFGERIRPSMYSMSFNKDVMCKTVCNRTYTPGDKVSQDKLSFLKRGIDLNYQHHWILDNMPITWCYKVESGDTYCSTGFPIGCYVTKFGNRKDTCITQPSMTKMDTYYLYNHVDIFVEYHPLSDEDWSASHVGTGGRIVSAKLIPRSINHPDQGSDSCNKGGVLGFTGGKLDEKLIIRYTYSVKWKENTKIKWTSRWDYILESMPHTNIQWFSIMNSLVIVVFLSGMVAMIMLRTLHKDIARYNQIDSLEDAQEEFGWKLVHGDVFRPPRKGMFLAVLVGNGCQLFFMTLITLVFACLGFLSPANRGALMTCALVLYVCLGTPAGYISSRIYKTFGGEKWKSNVILTAFFCPGLVFGIFFLLNLVLWAKQSSGAIPFTTLLALLALWFGISVPLTFIGAYFGFRKRPIEHPVRTNQIPRQIPDQSLYTRPLPGIVMGGVLPFGCIFIQLFFILNSIWSHQTYYMFGFLFLVFIILIITCSEATVLLCYFHLCAEDYHWWWRSFLTSGFTAIYFFFYCIHYFFTKLEMSGFTNTFLYFGYTAMIVFLFFLLTGSIGFFACFWFVSKIYSVVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1P4</accession>
    <name>A0ABM1A1P4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101854261</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101854261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939032.1">
        <property type="nucleotide sequence ID" value="XM_013083578.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854261"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012939032.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25257" checksum="957EDEF6FCFE1D07" modified="2025-10-08" version="1">MTFCAGTVSEKKAPELPKSVVVYYQICNDTQGFVDCVLKLRTTEEPLPPGVEIRPELKYFPLAFPLTTTTSIFCNELIPQPAHLTSRMILCLNRMNESNEVCSVLAAKKNLTMIRQQIIHVAASGLVNQTYNMSCDAIAPMRKCQMDSLLECDEDIWPMRTFELGLLGSWCLERHEEEYPVPPRGHCQLSHCSNTSASTSSHSCWLLWTLTPPLLMQTSLSWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1S7</accession>
    <name>A0ABM1A1S7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012021</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939078.1">
        <property type="nucleotide sequence ID" value="XM_013083624.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012021"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939078.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31304" checksum="AB0455B0C66790CD" modified="2025-10-08" version="1">MANAGGISVTDSAVYKVIRTHRNSHSRKAHQGQSRHSFCDNEGTRWAFLQRLLAIEEAHDQKKKMAAYSIEQTWREDKSRFRKQDSVESPLPPIDPGSRWIHDQVLDDDSPEDCDGTEHHDDLTYKLPSLETTNRELEPHRAHSSSDNYDTQFPRIQTDKGLTGSVSNASSMLQISVKAQSFSELSPQVDELDRGSSARLKRKRPLRLPPILLPKVYTIAQRPLQCREFLTPTKIRGPITDSEWEELKDCRYIRHALPRFSLQVSSSNVSSFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A263</accession>
    <name>A0ABM1A263_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multiple PDZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939309.1">
        <property type="nucleotide sequence ID" value="XM_013083855.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862466"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06673">
        <property type="entry name" value="PDZ10_MUPP1-PDZ8_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06674">
        <property type="entry name" value="PDZ11_MUPP1-PDZ9_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06676">
        <property type="entry name" value="PDZ13_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06670">
        <property type="entry name" value="PDZ6_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06671">
        <property type="entry name" value="PDZ7_MUPP1-PD6_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06672">
        <property type="entry name" value="PDZ8_MUPP1-PDZ7_PATJ-PDZ2_INAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="147"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="322"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="505"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="689"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="827"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="923"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939309.1"/>
        </source>
    </evidence>
    <sequence length="1257" mass="132060" checksum="28781C7FC0AD6B80" modified="2025-10-08" version="1">MTDSFGATSTPRDPAHPVSATPHLSSFKVVTNSAAPLLSYEEATRGMTEPETEAPAPPPREESVAVDRQANLSHAPIAKPDSADSDSDQRHARSGIMHRKHSSSSSPDPLTASDLRSPPGSPRPHSPGRSSLASPELGRLPSGLEKTIHVKKVNQHLGLTVEAVDKAVNGCQIKSIASASAVEQDGRLQPGDLVVYINNESLRRITSAQARAILRRSSLQGSDVTITYIAASAAASGRPPAAPAETQQSPILQKLVHSLKLEQTEVPLSETAPSEPQAPPPDAAGEDSAPPPADGKGGAGQKTLQTDGSPAVGNQAWGPPRPVELVREPGKSLGISIVGGRVDMFNVSQEHCNAGIFIKHVLADSPAGRNGTLKKGDRILEVNGSDVRNATHDEAVEVIRNSSSPITFVVQSLSYSSCPGDLDSSQLKTVQSFEETAQQQSLAQTVTVSLASPSLGSSTPQQSFEQGDGKGAEESFSDSEEEDEYGYTRRRISRKYSELPGVVQLVDLDRGSAGMGLGLAGNKDRSKMSVFVAGIQPDSPAARDGRIQVGDELLEVNGMNLSGRSHLNASTVIKGVNTPVVKLVTHRREDFLDHMAIKPLRYGGSSQFDAQSVPPVSPRPDSEPTSSSSSRRESRDAIPNSSTNSTATATAATAATSSPTAGAATAAAPTANANDASSLGLSNADTVQVIVLQKLGSQGLGFGIQEDTKNDRHGIYVKSITQGGIADKDNQLEVGDEILEVGEKSLSGLHYDKAIDILRAAQGSVRLKVRKVNQGTVPGSASVANSGSSQNKMQLLNTLGESTTDPGDAENDGDPRTCPIVLGKRTYIEIEKGKTGLGLSIVGGSDTLLGAIIIHEVYEDGAAARDGRLWAGDQILEVNEEDLTEATHNRALQVLRQTPPIVKMAVYRDESQVREEDILDVFSVDLVKRPGKGLGLSIVGKKNDVGIYISDIVKGGVAEADGRLMQGDQILAVNSEDMRSSTQEYAAAVLKTLMGKVNLTVGRLKAGSKASSRKNSNHGTSLKKSDSSVSNKSKGRHSKNASEDASHLRIVDLEQDVSGSFGLSIAGGVNSPIGDAPVIIASMNPTGPAAISQKLRVGDKILSVNGVSTDGWSHDQVVSSLRASKKITLHVMQGEAVSISGQRSRQVSGDMSDMTLKDVNIEMDDDGQPPQFKTIMLNKGPEGLGFSIVGGHGSPHGDLPIYVKTVFNKGAAADEGSLSRGDQILSVNGQSLEGYTHEEAVNILKNAQGIVTLGILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3I1</accession>
    <name>A0ABM1A3I1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COMM domain-containing protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940086.1">
        <property type="nucleotide sequence ID" value="XM_013084632.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850575"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037360">
        <property type="entry name" value="COMMD9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048676">
        <property type="entry name" value="COMMD9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15663">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15663:SF4">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20923">
        <property type="entry name" value="COMMD9_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="122"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940086.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22267" checksum="793D4F68800EBCFB" modified="2025-10-08" version="1">MRVDYNSLNNLLKVPSKQELVSLCQNAFLYRKESPAQWPDSLIQSTSDMLGLSVAETQQCLLTLSHLIKAALFQGSTDPQEVITLFPDNFHKNLRDLLTKIIRDKMDSWRADAVNSQVSLPRLVDMDWRVDMMTSSDSVARMSVPTCILNLQIQPPAAHLDERPLAEKVTVELSEETLHTALDGLGKIRDQLASVAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3L2</accession>
    <name>A0ABM1A3L2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Muscle, skeletal receptor tyrosine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101849550</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940145.1">
        <property type="nucleotide sequence ID" value="XM_013084691.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849550"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF317">
        <property type="entry name" value="MUSCLE, SKELETAL RECEPTOR TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="96"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012940145.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="51960" checksum="99E2B693078589AD" modified="2025-10-08" version="1">MDDYSTYSGNIEEEEEEEVDMFIWYIVIAAGTVMVIIVIITVVSVWRCRHSHYTATPQDDLDIDVENLPINSAYHQMKSNRLNPKLESLEFPRNDIVFIRDIGQGAFGRVFQARIVCSNGNSHLTGGKLSGSKHSLSCGKNCKHNPRHVFSSKGDLRHVDVSAAVRGCDSQLLAETKCKSSSCDNVLGEESKCGEGGQLIAIKMLKEDASETVQSDFEREASLMVEFDHPNIVRLLGVCTVGKPMCLLFEYMSKGDLNEFLRLCSPDQCLLRSDACSNPSLEEVGSIDAVDQLHMARQVAAGMVYLADRGYVHRDLATRNCLVGSGLTVKISDFGLARSVHSMDYYHGSDKDAIPIRWMPPEAILYNKFSSQSDVWSFGVLLWEVFTFAVQPYYGMTHEEVVNHIRAGHVLAPPKNGPSAIYNLMKSCWHRKPNSRPSFVSLQKSLNMMWEEMSKQRTKNVVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3T5</accession>
    <name>A0ABM1A3T5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940255.1">
        <property type="nucleotide sequence ID" value="XM_013084801.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012296"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940255.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13882" checksum="0BEBB3EA2BC67057" modified="2025-10-08" version="1">MCFTGSTCFSYVFSLFSFLSQDNTEPFSTRFLLSDNVYAKAVVPPTEKVCLWLGANVMLEYEIEEADEVLAKNLDAAKKSLSQVEDDLLFIRDQMTTLEVNMARVYNWDVKRRQAEKEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3W6</accession>
    <name>A0ABM1A3W6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase 1 regulatory subunit 12B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101859180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940307.2">
        <property type="nucleotide sequence ID" value="XM_013084853.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859180"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF188">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="763"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="814"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012940307.2"/>
        </source>
    </evidence>
    <sequence length="928" mass="101422" checksum="DD6A1CDC196A9F55" modified="2025-10-08" version="1">MNHHASFGILLHKGRKGSVSQSEDQEEFNSSDLPPAHQAAADGYIDTLTEVVQKDPSLLEQYSLDGLTPLGQAVLCQQLDAVKRLIKLGANIDAQDNVGRTCLSIAAYQGWHQGVMCLLRNGAKQSICDKSGRYPLHAATYHSDMSTLSLLLNGLTSKEINLADHELMTAVHWAAFHDRPEHLLILVQKGGDILSRDVDGKLPLHWAAQNNSFQCAHRLTSLTEGLATVNDLDFSGKSPAHYAAASGASNILKILSRCEGCNLEIEDPDERTPLHWAAAMGHGKAVETLLNLGVDPFPMDVDGGTPLEYALQAGNKECVKAMEDCIGTPEVKLRTESKENSKIKQMRPEHRYHFRKPKSTEDAQSVEVPDIEVQPPTTVTKSNSNRTVKTVPDMVPRMYSASSTDTDAYDFQPPVTVRDLRYEDEHHSSEDEVKNDKTPEKKPSETRPTHSKERRDSHDKKQESAIASLIGSSFMAGARAPILHPSPKASAFPLENLRIEEDEYVPTSAAPDGTEANKWARSVKVGINSGDKSGRQNSDMKVMTSTNTPDLQRVSVQSFRSIPPIPSNPEGAVSPRGSGRNIPNPKLKGARFTPLPGISTEGKSQLSPLVQASEGCTPTSEPVSYRDPSGSLAPLKAAPLRVKASPGPDTTHVQNDHIPPPLDFMTENVSETRVLTKQWRESLLKLHNRGEVPKQVNSWAGGTASTGNKTTTKPSRSKDQKGSKLPEGQQAAPSNLMKHSRIPSTLVHGGDVANDLSALALTDGSKTRGRKATKGKTKSRSKKTRTQLHVEENNGSCSVELPYAYDKYLREDDEHAPLSPTPLQSNPATYRAGGLRSSRKPVTDTQNSLRSSRKPTTDVQSSLMTRANYRHPSVRANDTVNVQEQMQSQNSHKTPQVSSHTKPVSIVASGKPQHMTRPKPQVRVQMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4Z0</accession>
    <name>A0ABM1A4Z0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101854351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940929.1">
        <property type="nucleotide sequence ID" value="XM_013085475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854351"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01116">
        <property type="entry name" value="P_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="703"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="284"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012940929.1"/>
        </source>
    </evidence>
    <sequence length="778" mass="86208" checksum="9BFC0257FB07BD13" modified="2025-10-08" version="1">MTSPRPSSAMDFRRQSTARESETGGVGLRLNPNRARTPRSTSVVSYLSESEPQSPSSPNETNLDQVQLNSHDSEKTPLIGKESSNSKVESGMSGFSHTVSQEISGVDKSSDSLTGLRDIFHLEPSKRNRKLFHTIKVSILIAITVMCCGVIMVCEEEEPLQKVTLLPAGETLFLLSENRDASRPNLRLQVSGPFYSHLEVNVTGPVVTFDMSPNYSHNVTINMTALAVGDIESFTEEFECLSGSVCNLTARSDVQIPLSWNHKWLSWQLDNEVIYAFLVLGFVYIMIIFELVHRTLAALLGALAALAVLSALNQRPSLEVIISWIDMDTLTLLFGMMIIVAIFSETGFFDYSALQAYKLAKGKIWPLVTLLCVFSAVVSAFLDNVTTILLMAPVTIRLCEVLNLEPRRILIAEVLFSNIGGTATAIGDPPNVIIVGALGSQGITFTTFTMHVAPGIVLICFVGYGLLRLYYRNMDELKNKDPPDISEMKQEISMWRLTASRLQTVTREETLMKALFLQKAVEMEHVMYKTLHRMRREEQHDMIQTLRKLERQYYIKDFPLLLKSGFVLCVVVVFLFIYSFVEQIHLDIGWIAVLGALWLLVLADNDDMEGILHRVEWSTLLFFAALFVLMEALSELGMIKTIGDGIADMVKSVDSSDRLVLAVVAILWISAIASSFIDNIPYTTAMVPVLQQLSENPDLDLPLLPLVVALAFGACLGGNGTLIGASCNVVCAGIAEQHGYGFSFVEFFKVGFPMMLVTTAAATVYILLCHVAMDWNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5B8</accession>
    <name>A0ABM1A5B8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012516</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941122.2">
        <property type="nucleotide sequence ID" value="XM_013085668.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012516"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054446">
        <property type="entry name" value="CIMIP3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35444">
        <property type="entry name" value="RIKEN CDNA 1700001C19 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35444:SF1">
        <property type="entry name" value="RIKEN CDNA 1700001C19 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22581">
        <property type="entry name" value="CIMIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941122.2"/>
        </source>
    </evidence>
    <sequence length="127" mass="14429" checksum="F952F8A319C7AC6B" modified="2025-10-08" version="1">MTTEVSQPISFNLNSSHLTWERLESLRLRRLGIPNRYSRHCNIVYNSQAAAMNAAERQRNQSATAGSLDKGGSKPPKRATNNSLAPFYTHEKRTCGYFFSRETDNRKRNFGIPPSDLVAWRSSNPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5X7</accession>
    <name>A0ABM1A5X7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012597</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941455.1">
        <property type="nucleotide sequence ID" value="XM_013086001.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012597"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012941455.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15748" checksum="A9A98833842CD43C" modified="2025-10-08" version="1">MECEELVCRHLQVQEFNLKIPELEEEMFDLQRQIDHALSYGPYMSGMQRSASAMNIASLPDETDAMSINIRIANKLYDRYMRAYDNLDHLKPYSPGQRALHKHIKQAMYDFYLKRRDQLKSTLRRRDSCNSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5Z1</accession>
    <name>A0ABM1A5Z1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101853478</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941487.1">
        <property type="nucleotide sequence ID" value="XM_013086033.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853478"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF83">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="75"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="316"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="920"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="933"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012941487.1"/>
        </source>
    </evidence>
    <sequence length="966" mass="110803" checksum="C263A0CC59BFD820" modified="2025-10-08" version="1">MAHKYSTGVAVDDKTSGNEDARIELKKFSKANGVEDEAITANAVVVDEDGDADGQMADKTMDKPKDDDVYKRNLFFKDGTRRIDFILSWSTEVTKKSAQAIQARKIFEENLQKEGLQLEYDLSGKETQFVKVHAPFEVLRRYADILKMRMPMKESIAEQHIKDRFSDWEGGPIDMTPLPSFGAKVWEHTIRLFRRILVPFQYDETMLPPLRRSYTCPYSANREYLFEIPKNKDELFSHATRSWVVDYILRRKPFSVSTDNFAYGVNKMIKDQIYTAAFPLHEGHWKTGSAENPRKILFDHWAHWRNCLKFQPLGHVRLYFGEKIALYFAWLGFYTTMLVPATIVGLAVLIYGLAVMGTNLASKELCESDDIIMCPLCDNHCPYWRLSDACSHARASRVFDNGATVFFAIFMSLWGTLFLEFWKRKEATIQYKWDLTTFVSEEEPPRPEYLSKLENWHTMKINPVTGLKEPHLPFWRRRFPIFLCSYSIMLLLAAVAISAVIGVIAYRVSMLAALNLIPNEVGNVNSTVVTTTAGLIYENASLVTTVTAALINLAIIIVLNLVYGYLAFWLTDWECLRTQTDYDNSITIKLFALQFVNYFASIFYIAFFKGQFVGRPGKYRTIFGGRQEECEAGGCLIELCIQLAIIMVGKQLVQNNFIEIVLPKVIKFIKRKLSKETREQKLGRTPWQKDSLLDPAQSMSLFYEYLEMVLQFGFLTIFCAAFPLAPLFALLNNIIEIRVDASKFITQLRRPVGDKAATIGIWFSVLYGISRIAILTNAFIIALTSETIPRLVYQLRYSDDGSLAGYVNFTMAHFNVSDFDDAHRPTDRSLGDVGMCRYKDFRNPPWEDKDYRRSSHFWHILAARLAFVCVFENVVVVVTSLIAWLIPDVPSVLKEQIRREAYITNEIVLKTELRRAHGEEVTEDMVSSLTTEETERYSPRLSEDMEVTHRRPGATASDPSDPRTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A672</accession>
    <name>A0ABM1A672_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein LOC101864474 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101864474</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941591.1">
        <property type="nucleotide sequence ID" value="XM_013086137.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864474"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15440">
        <property type="entry name" value="7tmB2_latrophilin-like_invertebrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048072">
        <property type="entry name" value="7tmB2_latrophilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1206"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1243"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1267"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1310"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1350"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1418"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1447"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="137"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="15">
        <location>
            <begin position="1011"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="17">
        <location>
            <begin position="1206"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="492"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="567"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1074"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1545"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1691"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1754"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1836"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1551"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1754"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1777"/>
            <end position="1798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_012941591.1"/>
        </source>
    </evidence>
    <sequence length="1891" mass="208165" checksum="819FC854432FC9D0" modified="2025-10-08" version="1">MNISEKPRFVNGMPDSAGNIEVIQSSLKASLGGRDRDRLDEDVAAASKRVLLHNIEFLPASAPYSIQRDTLRAKYIPLNSAPTQSRPWGDGSTPQHQAMTSSAHSDKNGDSLPSPRVVLYPEEKVKMEWSRMTRIGAGLVNMGNTCFFNSTLQCLTYTAPLVNYCFTNDHREKCKKKDFCMMCEVQDHIRTSLDCGGRSIKPHSMLQKLRCIAKHMKWGRQEDAHEFLRFLVDHLQQSCLHGETKLDRFSKETTVINQIFGGYLRSQVTCLRCQGKSNTFDPFMDLSLDIKGVNTVEDALLKYVKPETLDNDNAYKCPKCKNKVRAQKRFTIQKAPNVLTLQLNRFDFNRHLSGKINRFIRYPEKVNLRNFMSQKQGEPVLYHLYGVVVHSGHSSDHGHYYSYVKSPSKTWYCMNDSSVHQVNANTVFNSDAYVLFYARINRNISAAHSGPNNVHAKNSSPVKVPFSSVMIQNHLKQEKTQMVNGIHGKATSELGTPIKRQQPAGSSLSSSSVANGPKIVPHGTSPSALPGAHNKISFPILTPQQKKQLHLQQQKDDGKRIVLQIKHGNSTTMEKSPDGKSKVVNGGGSNKPAAQLKSSGLVPYNDDSDSEQENNSAGGNSVRLNKSPHHRTTDVASTSSSASGGSYIQASGDHHHHHNYASVRSIPLPSDSGDGHKSGISSTHKTSVSSDMQNLSQTKDGSRSPHVHQMHSQNGIKQSPRSSDTHRWKGSSSPSSSSQHSWVSKKVNAQGNTATTTTTSTTTSSTTTTRAPLTRSPPHVAGDGDDDDDDDHSSPWPTPSIEINDKHGTPPQRRPVLTYCKETVRDDMRWPRTRFGHVARRNCSGGQTGVAKWQCLSTGWFKFGPDLSDCVSVWLDAQLKSVESETPVNEAAAELSESVKSRPMTSGDLKLAATKMLPTLGKGLQRDMGVIPPMLRKRRMKKFKKDVMNTGSHLLSEDNQESWQGLSRQDRVWSATSLLLSMEDTGFQSAAVMDLGASEVTVDENIVMEVSVLDTGTSQRDVVFPSSSSLAHTPWSTSSDSITLTRDSVREAGGTGRLNVVFSIYRNMNELIQPEDNKLPSMPSDPDFNSGTIRDSEKDGKRRQPSVIVNTNIISASVHGRRPGMRLADPVRFTLHHLQPNNEAVPACSFWDVDQSAKSGRWSQDGCRMLDTNLTHTTCECDHLTNFAVLMDISGTELSRDAELGLIWVTYIGCALSIICLLLAWITFTVFKNLQCDRNTIHKNLVLTLMLAELVFLAGIAQVEHKILCSIIAGVLHFLFLSAFAWMCLEGVQLYVMLVEVFEQERSRLPWYYLFGYGTPVIIVAVSAGVNYQGYGTDKHCWLSTENHFIWSFVGPVLVVMLVNIVMLGIAIYIMCRHSNMSATMKERSKVTKFSVSDSLGSVETFAPPRLRFPDLPAWVKGAVVLMVLLGVTWLVGLLFLNKHMVVMAYLFTILNSLQGLFIFLFHCIMNEKVQKEYRKVARRTSWLPDCIRINYGGYNGGATTSPNASSGSGNFLSRLFGQGRKQSAASTNSSARPFLQKDAHLRSDGENSSSRDNSTAPSSLNGYVYNPQMYSNGHSKAPLLMNNNGGVKGSNNGQLLTPCYETLDGVAGDLSEYLECSVVNSEFVSEYCQDNMQVSQERRRYSTGSEDSEMMSSQLPVPHVMDHDNLSNLSVASSTRKPASFAMTSDLGDHADLDDPNYEEPLPGDGQLDLLQYIIPAKKRNGEEEDSGCDTTQDRRTRVCVGENRHLSPAAAAASEGKSSSLNKLTKPAGLSLSSIPETTDPSSPQHSSTPNLQFVPGYVAPLPHATSSPITNGPPDMSLFPSAVAAACPVVSSPDSDKSSLPNLAVDPLTVEVTDNGSHDSDHKKRHSSGADLQFSPFKFSSSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6I8</accession>
    <name>A0ABM1A6I8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Advillin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101854815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941780.2">
        <property type="nucleotide sequence ID" value="XM_013086326.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854815"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF51">
        <property type="entry name" value="PROTEIN FLIGHTLESS-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="4">
        <location>
            <begin position="864"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012941780.2"/>
        </source>
    </evidence>
    <sequence length="947" mass="106842" checksum="B0AED2C2155A86F9" modified="2025-10-08" version="1">MRGRRLIDVSQLEAPGDGQSSHSWSTVTTPFRNTQTSVKVSARSLCSSRRTSGHNSRITSARSSATSAALSTVTSPSSYLTSTLNSRATSAVSRGSSSACRNGKMKRGCTAPAALLQAQRDILAEFSTSRPGLNVWCIENQRPQPVCVSDHGFFHQGNVYVVINVEDNGTVFLHTWQGRLSQKVDRDVAAFCAEELDRNSEGAALMSFEFEGKESSSFLGHFQDGVIICEGKTKQFLGRASKYQKRLYVIRGRKVAVASCTEPSSSAVAPDVALLLDGYPRIYVWIGDRVDYVSRVKAINLAKKIRTWQRDGKGHIVVIDKDEKSLSESFLKKLQICGSSESQQEDQTSPEEDQVRAVQLFRVNGDRVMYDMPLAAKQPLKQKLLTSTDCFLLDSGPSLPLYIWVGARAEPDDRRRALFRARIFAQHHGYPGTTHLCRVAEGEEPMDFRKMFAEWRDRTAGERQLVRSYSVANIGRVLFSKSDRRTVAKLSELWSDDHFLTGNGNTEMWQVNGGVVPVSQNPEGLFYNNSCYLLKHTETVGNQNVTVLYTWMGQKSNPEDQEKVQQLAADMDAALDHETAIVRVLDGKEPKHFLNTLRRSMIVFDLSLLSGRSSSGGSGSCTDPDVWMYCVREVAAETMRVTQVPPTSTSLNSSAAFIVITDNSSYVWYGKNASALEREYSKSMLAYLCPTKSHDYDIIVEGKEPTSMWMVIRYDGVYPKEFPKPNLERRSPRLVLCRPLKGSWVFEDVPYFCQEDLCETDIFILDTHDQIHLWCGSAVADRDHSLYSPVIQAYIDRDPSLRQSEDLKVWVVNQGHEPSTFYKFFRSWEEHGYGGEISYSAARKRVRQENAMIDSDCQMLDLSHLHTTKVSYKDLVKEENLPNDTHINHKEFHLSDKEFTRVLRMPRAQFYRLPFWKQRQILKSAHLADPQTDGPSTPRSLVTSQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7C7</accession>
    <name>A0ABM1A7C7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylcholine receptor subunit beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942261.2">
        <property type="nucleotide sequence ID" value="XM_013086807.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854114"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942261.2"/>
        </source>
    </evidence>
    <sequence length="182" mass="20354" checksum="AA7ED46B4CFF18FE" modified="2025-10-08" version="1">MSQSFPGLSLICGDKDVSASSQTESAPTIVSSGIIPQTTLTFHQAADIKGQQFGVTGWWSMRWTDTRLSWDKSNYTGIPVLQLDDDKLWTPTLVVDNSVNDLSAIDEDTIPVRVNDKGVVTWNPPGLLLVTCEMDITYFPFEVGGFCELHVECTPKNVFLLKIVLWHCYRSSFSCRLRLSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7L2</accession>
    <name>A0ABM1A7L2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101856529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942396.1">
        <property type="nucleotide sequence ID" value="XM_013086942.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856529"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF11">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012942396.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="60284" checksum="78F4F5992CC884BE" modified="2025-10-08" version="1">MATCGSVTQPQGAPPPNFGNMDYLGATQNATYTTGPRQCTQFTPLPSIGNMQRSYKAYDTYPAPTPMRQSLTTLPWRPSTYYQSAKVNPCTAIGRSMPDPSSARTQLTELDSLKVPPVFAAARNALYTRFTHNDWLASNQGNYLASDRVRGGAERLRFDTTRLAKEYDDKTKRTQSDVNKRLGERLGDINFWRTELIHELDSMITETNALNEAKRILEKNLAESENPLHISQECLYNREKRQSIDLVHDLPEKDLIREVDLIKRCQEKMRNTIDRANVQLGLNRAAQHELERDSGDKFIAENLDNTSHMLRNSSRGIAYHDGVHRIDNTISVPETWAKYSNDNIQRSQAERAASKNMRNEIECVINTCNNEMWQMWNTVNTALSNRIQETTDARNKIQTHLNRTLQEIFDMEKNVELLKKSIHDKEAPMQVAQTRLDTRLRRPNVEQCRDAVHTRLVEEVGEITDTVDHLQHRLREAENALQALLRTKGALEQDLTIKNNTLFIDREKCMAMRKTFPMSPRLVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A895</accession>
    <name>A0ABM1A895_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM91A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101859663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942725.1">
        <property type="nucleotide sequence ID" value="XM_013087271.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859663"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="4">
        <location>
            <begin position="389"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012942725.1"/>
        </source>
    </evidence>
    <sequence length="910" mass="100055" checksum="7BC3B5C49402589A" modified="2025-10-08" version="1">MSAESLAENHIRQNHSWQKLPANVKQSFNSQREYEKAVVTFSIKNQLRYKGNLVKTVRKDEPRYYEELLQYSREHLMLYPYHLSDIMVKGLRVTPFSYYSNMMQDIMGQEKSYDSLPNFTAADCLRLLGIGRNQYIDLMNQCRSSKKFFRKRPVKELLPGQPIEGVTIDPWWIVQVGFVTEDDIRLCNDAEKKVIDMVIDTGPQVSGELSKEVVHSLYRKGLIYLEVPMLDDDCISVPPLEGFVMNRVLGDYFETLLYKIFVSIDEHTSVAELANVLQIDLSLVKNAVSMYCRLGFAKKKSVDFDLSDLHPSWNEQDSPTAGPSKSSPKVNEERQLLIDFSSSVSLEASDMNKSTSSTGLGGAVSGSAADAAIAAGLESNLDLGTQASVKRIAFLFDSTLTAFLMMGNLSPGLKSHAVTMFEVGKLSDESMDSFLSELEKVGSDAEGEARRYFDHALTLRDTVRFLRHNRELTEEIEGAAVPSGQGIDLLRCESLLGLDPETRSRVLNKNYSLLVSMAPLSKEIRPVSSSAPQHIGPAIPEVSSVWFKLFIYHLTGCGPPSLLLMKGTKLHRLPRVFKQYDRLLVTTWGHDPGVIASSNILLTLNDALTHSAVFVQGHGVHAEGLAVHVPFPFDKTQGTFSEGHHQCHVVMSRLSETLDLTHTCGYVTLLNPHKEEVHEDDLEGEPLVPGTAMISDPSVPSSGADESASAAAAMATSAQSDTTASGSATEMSDSDLALLPHNGIKDKHSAEVLTSELDSLEAAGAGGGGDGGAGKAGLHLDVKSQELKDSAASSSLSSSSRSAEPLKEEEWLLLDLCFGLPLFDTALNRQVCGRITKLGLFKQESLQELTSSSRLLSLKLLEFIMGWQVARVVSEVDSHGVPQNRDEHCSIFPSQNILFDGTRVQVWKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACK3</accession>
    <name>A0ABM1ACK3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat and KH domain-containing protein mask</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101861402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945114.1">
        <property type="nucleotide sequence ID" value="XM_013089660.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861402"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF5">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="56"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="172"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1393"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="842"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="896"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1273"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1309"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1322"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1442"/>
            <end position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012945114.1"/>
        </source>
    </evidence>
    <sequence length="1451" mass="155736" checksum="C87F8191C31E210E" modified="2025-10-08" version="1">MSVSAAAQIMRQADTVKNTMTESGKSLSELWVTRQKLEDLYKRLLLVDLEYALDKKVEQELWNHAFKNQISILQTQSKDRQNPKKIEAHASLLLFLETASGFYLQFLQTICSTFKLDLPFRRRSAAFGVMRENIMNYKKIVTPKKSSCLYICCHCLVHLGDIARYRGEMWQAQTYYRHAANLSPNNGQPYNQLAILEASKGDKLSTVFYYVRSLAVRHPFPVAATNLEKFYSKLIKDTRSDFDGPNLTMTDIIVAFLQFHALLHMSTGLDRASYLKTRITSALGSHIRSQSVSAAHLTGMVAISVFALHRARCDDASDTGEPARKPGLSSEEERCVQIHLSFAAKLLETLLQHTPKEDNKARDYLTLPAIKVMFDWLSVNRDVLQGREFNNSSIWQDFCKLLNIIQWLLNDTNKASDLPKYEDTPLPEDADLRCFQPLEPSYSSYNFNKALNEELSAACERDLRCQRLVAHGRWIAQDLPKLKLVLYQPTKSVRTQFSTQKVPQNIEGQQATPPKASQRPTVAMQTIMKKRTEPEKGSTSPLSVISEEGKSAQGDSLPAKTSSEQILASQQGQGQKGGSSGGGGGRQAGVINLHHKSSINQKPNLPPRLSAKAGNAQTSSLSPRLQKKGLTRGGGGGHSTGSSGRGGGGGGGQVNKVDTDGRPDTAPAGAATATIPTFKSQEPYPSLSADNYPALVNQRTQASLIPSENLSQNSSSGGVSGIGVGGLSAGLNWGGFGLGRDNNIGGGGSGGALHQSTSPMLSIPGGGGGSPSLDTCSNSSRSPQPSPNLASSFASLELPVRNVDMGLSTTPTGVDQTTLNFPATTPSADFLSAIRSASQFVQQQQQQQQQHQQQQQQQQQGYQMLPPDMQPPAGPPQQQFPPHAHYSQQHRMLTAQQKQQMQQQQQQQQQQQMARNPQGYFQGTAMMPDQSAGLFKQPQPQPQSKNMLAPSGGVNPAGSVGSSGPMLRSGSAGGGGGVMTSGNLHPVGGLAMPPPPPPQQPTPRGMSQMMPSEAGGTSGPGMSYQANRGGDSSSSSSAGRSFMGGPAPVGFIPPASLVPPSSGESAYLTTAMAGGPVGTGRAVTGGPHQPPSMAVPGYRGMQHAQHAQHAQHTQHAQHSHQQQKQPQPQLMQQGNPPTPKSAGLLYQNIPLRGGANSGTSQTVGAGGGPGSASASGPNNQPPSASAMNSLFLAANLATNGRNPGQGPGLNQGPQSQNSAAFAQFLGSQQQQQQHGYLAGKSAAGPDPRLSSSFQGHAAGTPKPDKGLGLDSGLNPQLVKTQKPPQHQQQAQQHHLTQQQQQQQQQQLHTPHHQLHHQHHQHQQQQQQQQQQHRPHHHQHQQQHASSHQSLIHTVMDPPFLQASGEYTLFSNTNSSPAWPTSLVKTTPAALMKTAGHADGSSGPANMPVGQVIPSTTHSFASGNLQGMWSNTGPSPLERLLEQQRSQRQGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADS7</accession>
    <name>A0ABM1ADS7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bone morphogenetic protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101845741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945756.1">
        <property type="nucleotide sequence ID" value="XM_013090302.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845741"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13765">
        <property type="entry name" value="TGF_beta_ADMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF308">
        <property type="entry name" value="BMP-LIKE PROTEIN UNC-129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="8">
        <location>
            <begin position="369"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012945756.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="55280" checksum="3F209BC5EDE67E95" modified="2025-10-08" version="1">MKTRQVTSVKALVCLGSPWGHVSPVLVLVVISLALQPHQTWAAPGRSFPSMPFLPSSPSSSSPLSSIAVSASTHSSSSNRSVHHHHKGDSPPPPDALSRLSKVFGISRIPRRTFHRSPPQYMQELYASITDTGGLSKTSGPYNSNVIRSFPDKDSIHRLHFHYNTSYLESSEKILQAEFHLFKMRPGPAQSREPRPPHVILVKVYQVLDIRDMTSSRNLRLLDARRVSAHAHGWYVFNVTNAVLSWHFGKANNFGLLVTAETASGVHVNGSHVRFAQRNEHHDSKQPILVIFTDDGQPRHATYISPEDEDYQEIKADILRREQQKQHRQSSSFREAIRMLNERERRNRSRHSSRSKRSANNKNRGGNGRRKRTFDVYRYRHNRRSCSRYEMFVDFEEIGWSGWIISPNSYNAYHCLGECPFPLGQSQKPTNHATVQSIVHALGVGKDVGTPCCVPNKLYSISLLYFDDNENVILKQYDDMVVASCGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEC1</accession>
    <name>A0ABM1AEC1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Parapinopsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106013842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946057.2">
        <property type="nucleotide sequence ID" value="XM_013090603.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013842"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012946057.2"/>
        </source>
    </evidence>
    <sequence length="162" mass="18659" checksum="AF94325291CF3802" modified="2025-10-08" version="1">WEYPNKSFVTASFIGCLALPAFTMCYSYSRILFVALKTRHKRMKWKPRTKESRMWEKKEMRLLKMTVLMCISFMLCWTPYAVVAMIKSYSSHVTLTPLLSALPALAAKTSHVLDPVIYCAMNRNFNRFIPDALRKKRETDLELTTMSIPLKNVAHGATSSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPI9</accession>
    <name>A0ABM1VPI9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101860796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_035824331.1">
        <property type="nucleotide sequence ID" value="XM_035968438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860796"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035824331.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56809" checksum="858B86EEE6A87DFE" modified="2025-10-08" version="1">MLGKRSLKNCSLQLTCFILILLNVYLVLFSKQSQCPNVVERLRRNVVKAQKTGDNNETTKTHSSLTMNTSSQPEDISEMTPSQHPGPFHQIGDSDIWIYSAFYEPVKQGVDAPMIRALGVAMRNLSGLALSCHVTYEDRSVTTVSGRLRAALDHHHKSYSASFLYCPVTGTRKPSFVAFSLNKHETPGHEFQVMFPASKRERTFTVCYSVIYGNYDRYSMLLQSITYNRMMGAEHFFLYNQTMGPRADAVVRHFQDLGIMTVLSMPEFPANEAWYHSQIMAINDCIYRNRNISQFVAVVDPDEFIMPVQHHSWGEVLKAVTDREIKEKRGENVGVFAFEHSMFCNNRLNNTEWATFKKNFQLSDEEGKFIERNDITTLLELRRSNLVRFPVRSKCIYRPEVTRQPGIHYVRSLWSGYRNVVVNSSLGIIGHYKNRKGDCFLDHKIIWFYKKYLKALKSSYANVQAYLLNRSISTTNFQIYSNPEAKQRPITKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQK6</accession>
    <name>A0ABM1VQK6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118477403</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118477403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824698.1">
        <property type="nucleotide sequence ID" value="XM_035968805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477403"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824698.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="24988" checksum="5C9015AB5FB45E5E" modified="2025-10-08" version="1">MSANLKQLCKTLQKPKVQKWMTYIGLFLINLPGGVAIYYGNLLTYTASYLRLRVSEDVTHYIPVMITVWALLFSVALIFSKKVSSRCGTPLTMLLGIVTYDFSTLLGLWTVQHSVLAQTFTQGVMSGTGLVWCIRNIWLSEKCQIISPDNQTMASFADVKQIYKEEKNCILKTTPLTQAAVNPSRLQLQNVQHACTSPPSTVYMSYKPPVQTATSQASSDPSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQT2</accession>
    <name>A0ABM1VQT2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824774.1">
        <property type="nucleotide sequence ID" value="XM_035968881.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859232"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="33"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824774.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21560" checksum="EE45F237B7539511" modified="2025-10-08" version="1">MADAEKTREANSNSGINSNSGQSKRPSRDGWRLVIIAVDDEIVGRNALEWYHDNIHRPDNLVHVCHVPNFRDKVEPNMDPVAILRLMKNVNNFAEGLKYIYEGLLCELQINGKFIRIGGNTPWSALIEYCKRQKGSLMVVASRTRCPNTSATDLTTADLIMGSMTRDLLVHCPVPVLVARPPEQPKPRATGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VST1</accession>
    <name>A0ABM1VST1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Leucine-rich repeat-containing G-protein coupled receptor 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC118477628</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825473.1">
        <property type="nucleotide sequence ID" value="XM_035969580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477628"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051432">
        <property type="entry name" value="KCNMA1_auxiliary"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473">
        <property type="entry name" value="GH08155P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473:SF23">
        <property type="entry name" value="GH08155P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045389933" evidence="14">
        <location>
            <begin position="23"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035825473.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30388" checksum="3DCB0D2865D24880" modified="2025-10-08" version="1">MSSTSRIFSLILVAFTCSQSLAFEHAPRTGESPCDVTDDDVRGGDYVNCTVRGLTSLEPTWFPENATTLSLDHNILHNLASGCFSHLSELQVLTISDSRVTTIHEDALRGLGKLKELNLENNNIYTRRLSRTLFSHVPNLENLYLKGNTWENEGTLESPSSSAVPFSDLSHLTSLAWWLSWSGVWLHTTWVRLDMSGNYSCIDDRGQDRWTVDLVTTKALWRRCVGKTALLVSLSLALSLIVGFLAVYVWRRFRTAVWAFFLNILAPGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVV5</accession>
    <name>A0ABM1VVV5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864467</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826547.1">
        <property type="nucleotide sequence ID" value="XM_035970654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864467"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028:SF9">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826547.1"/>
        </source>
    </evidence>
    <sequence length="2453" mass="281307" checksum="909888953DFCF5F5" modified="2025-10-08" version="1">MEVNEKRAVGRKIIRSKRGDGRAHVVAQWEKVQDDFVSDNEKQKKTVKVIKRQPRNETDQRNAVSKEDNSSMQRAKSSLGFEHASDKSTKDNPHQQKSLSSRANLQSLKKNGVLLGEGLPTRGCSSAVGFSEKSSRYRGSVPTETNSGGFDEKKDELDLTEKLKAFRSLINPKAKFKAHDFSNEQLKRARSFSEGIEDMGGHVKFCAESVASRNPRAMTSPRELNEFQLTYERDREMSRRKNRSSLLDFSPENRNDGESRDIGDRVAVIARNYKATEESDAKAVNYRSILKTTERNDDDDTALDGKMAARSSKTDLRHTDGQTSPSYRPELRRVIKRPPSERRHHRGGSSDPDRRIGGSPSDVMGSEGNPEVIQYTTHFPRSASHVDRDVVDLDANWDRFEHRRSHSTTFPRNSVDPEEVRMTQNDRRSVEPSSYGGHFSRLAGRYFERSQSATPTTGRIVSDTGTSSALTRGALHETRSTPIRDASLKAHLNILGASLESLSSKLNSGSETDTRSLRSESLLSLSVQGGRYDDVMLSGARAQRRQGASGYGTRLHSGSDETTHPTGRARSVGASPVISASSKFERGNNNADESDRFRGAYKTGTALGTRESSPAKNSESSSVSPYPVSSDVTIPSMQLARASDSVSSVSGESPRVNSARSRQTNVQDYEGDNTLSNCSELDTSASDVNVQPSRRDRSRGDGITIQEVSNSSLVSSIDEQDKGDMKKTAKYLARYSGAASERKSSTSLSGDGAHGQRTSAGSRSEEKLARVNGANDRDISDESDSTLCDQSSRDIHGKVSTERKSGTERYSVGAGMHSERQESVRVISRKIPLSSSPVKAVHPSSRRQDHQKVHENLATSSHRKTNSSFTDRKPPLSEPTNRRSGDDSPYANDPHRRRDRKILVNRNKDLKSESSNSPPPSQHLATGSSSRPDAKQRTPERSKSALGLLMTKTGSLTSSPLPSKGSLAQFKAKLRPHSSMDSLHHHHQSPGTGSSLRNGTVSRSKRGRGSEDSSPAHSTKGGELLIDKVKKLHQEIESRLHSKENAAHNASNYDVGESSGEHSEEETSVKSEVSTVLSERRAHSRHSKSVTTKKSFQNSAQTEKEDPSRFSTSTPVKKAPVANSNLATVPHSQSTSSLEMKHSEGLRTSNPSLAHNLRHIIDARNRLTPDLNAMRKKYRTAKHDDSDAESLSECEDSDEELRKRRIQRPGSVGPSLEHRVNNDNNNNNNNKNNKKDIVSRILGKMASEMGGKNPSLYSSSSSSLAFSEHNGSHNGSHNGTSKWMSLANGVSVSGRASPAESLLGHLDNPGMVRLLQMLYKADPETRQLIMVKVQFFKAWQHFAVASRERRLKKESQFLAADTFCRQRLLVYHYITWYQRARHSRNSRQAQALFTRHMLTKGFNALRWSVSRSQHQTEKLQDKVHSMQLKFSFIKWRVRAESQRAERKHSAFRRWRQYAAETQKVRHMREVRHSNLLADAMRTWKKRYSRHYKQNLAFSHFRLGMLRHSLSTWREFIALSKEKKDKYSSAVRKHNHTLLSTTFFTMVLTYKKSRKARAYFRHQRLYEVFWAWRDASKICRTERQADMTLSRDHWQTHKLRSTFSAWRDRLMVCRAEKQANFKVCRNAFILWLQAWKKNVVHREMVETTLTRNKLRRALITWRQNVVQLRRQQRLAVGLIENCHLRQTLRTWRQYTAARVVLKKKASVHRATYQRKTLCSCFLLWMESCRQKMAEHQAWQFWSECCARKMAARWRQNCHKQILSRLLNDTQPQRESRLLHAMFTHWLASFERRNQEKEEAESMRGRLEWSRLQRNFEFWKNATQKALIIKPMVQRRERESMSSCFAQWQQFIAQKSQWKLGLQTCHKKNLQKAFSSWRKQYKAVQVEKLIKKQISNGLLLCYLEEWRFLILRKRKSRDFRSSQLLRNSFTYWSQRAVAQLRQRERMEEEEEMSFEMKHKYFWMWLENARGQGSETGQVLEGFLQQQERARVAKAFCMWRRHMHSTLIARAYQKSHSQRLLRTLLLAWQEAKSNAETDAIQKFSERIGLSEASGSDVRQDTQNSSLLYLQDGGADGMWELDFTLEDNDSGRFNNSFNSSLSLASSARRQMLAELFGESEGSGYLEGDTDRQALLCGGLQAAMDEHQARCARLKDTVQAAITRLQNWPTCVAFQQWLEFTARQKELKSLALAASHLHTTTEMRLAFREWCRGCDATRKAARHWSQQMLGKCMEAIRLYKDHQRYKKLLSALAHRHATMVAFHKCFPVWLRKTRDQRQEKNILHLWSSRTVRELELLPLETELTASLGQRSLSVCFSLWSVRYQTVARLRAVYHRSLLSWVWTAWRNWATERHELMSKSQSFLKRRREKLVFSFWLDRLHQSREVEKKYHLAWSNYQLLILREWSVWAKMNQKLRSSQTLFMQQMSVRNLGTSFSRWRSLTLKMQALHSTHRTKVMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWP1</accession>
    <name>A0ABM1VWP1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUAK family SNF1-like kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826833.1">
        <property type="nucleotide sequence ID" value="XM_035970940.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850423"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826833.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32767" checksum="3B79843BD70D7900" modified="2025-10-08" version="1">MESSSVPLVKFISGDFWSSVKMRQVRVLCQKTITPVQVLEAAMEDDNSIRKAIKKIRLTDCQGRDSWLEIFHEISFMDYASHPHIMKMDWAVKCKDFVAICMPLCSRGSLHDARHRLNREQLERCFVQTACALRYLHNRWAVHGDVKPANVFLDESNNAILGDLGMSRLLAHGQNRVSSKNVLGTKGYLAPEIQTDITVDPFLSDAYALGATLWFLVFKRKPRDGEDLLHAVKSDRTLMPLLGFFRFVLYRLVQNNPRLRLSVCHLLEFLRERFQQFRVIIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX40</accession>
    <name>A0ABM1VX40_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14" type="primary">LOC101857582</name>
        <name evidence="10" type="synonym">LOC101850097</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005102644.2">
        <property type="nucleotide sequence ID" value="XM_005102587.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005103537.2">
        <property type="nucleotide sequence ID" value="XM_005103480.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826979.1">
        <property type="nucleotide sequence ID" value="XM_035971086.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826981.1">
        <property type="nucleotide sequence ID" value="XM_035971088.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826982.1">
        <property type="nucleotide sequence ID" value="XM_035971089.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850097"/>
    <dbReference type="GeneID" id="101857582"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005102644.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005103537.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035826979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035826981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035826982.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="57034" checksum="A5E64CAE38CBB13A" modified="2025-10-08" version="1">MVAIEGRKRAMRLNLSNLVGCVMMVVTALVILNVVVILQSPRAEPDFFSQSQQSPDRDVSVFQPKAWGEDTRRPATAHNVTADLPRIKVKVISTQVCPGLSVEFSTSADGTFQRVDGYRALLYSAHLDEEEGVVRVVLLRLRTNPKGGLLCQGWYPGREGEPLEVVEGGIMDLPESHGRSFTTSLLTCPLAAKRDGSRLVAVSVVVKKCDVAPNLLFLSEVSNSTLRDFTVCVTPLNFRYSRAYELVEMIELNKVLGAQKIVFYNFSTGYNVDKALQYYTLRGDVEILPWHLPLRTDTWPPTKNPPEIHYFGQMAALNDCLYRYRASSRYIVFQDLDEFIVPKTYANWSEMVSVRQAKQPKVSAFQFRCVFFRKEWPKLAEDFEGNDVALRYNSVVLRHTLRETKILAHNVRSKFIVIPKKTKVVGIHTLWKHTGVIDKVPDSDALLHHYRSWESPNDQQPKLDDRTLVDKFGPRLVKKLAKSWEALSDIPLDVDLKSYGTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX94</accession>
    <name>A0ABM1VX94_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC106012477</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106012477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827037.1">
        <property type="nucleotide sequence ID" value="XM_035971144.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012477"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF44">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827037.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15542" checksum="CABF52BC47BA6454" modified="2025-10-08" version="1">MRQADIPEMRVQDAYLNSYRAYTGPQDGAMGVPLGSLSRPTRGYAPPPPSSTMTSESSFLQFRPSSFRILTIVSAFLCFCPVGIAALVYSCRAQWAKKHGNFGKAALLGKSARDLAVASIVLGTSMALVILLIGILLFVPGVTQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZM3</accession>
    <name>A0ABM1VZM3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1-deoxyxylulose-5-phosphate synthase YajO-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118478411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827866.1">
        <property type="nucleotide sequence ID" value="XM_035971973.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478411"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827866.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15560" checksum="40A148D30CD839C8" modified="2025-10-08" version="1">MSAIPEEKKVLYPFLGRSGIRVSNLCLGTMTFGEHQMYDNLEFRSLQQQYNLACRESELEAFQVCKAEGMAVMPWSPLKGHFSRSVPQIALRWLLQKDVVTSVIIGARTLQQLDDNMAAANGWSLSKEEVGSEHLQGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1R3</accession>
    <name>A0ABM1W1R3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC101861240 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101861240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828606.1">
        <property type="nucleotide sequence ID" value="XM_035972713.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828607.1">
        <property type="nucleotide sequence ID" value="XM_035972714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861240"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08521">
        <property type="entry name" value="C2A_SLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04020">
        <property type="entry name" value="C2B_SLP_1-2-3-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15747">
        <property type="entry name" value="FYVE_Slp3_4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043567">
        <property type="entry name" value="SYTL1-5_C2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716:SF2">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RabBD" evidence="6">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="1428"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="1589"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="557"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="618"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="809"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="926"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="1080"/>
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        </location>
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        </location>
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            <end position="1280"/>
        </location>
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        </location>
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        <location>
            <begin position="1585"/>
            <end position="1606"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="232"/>
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        <location>
            <begin position="266"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="291"/>
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            <begin position="322"/>
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        <location>
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        </location>
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        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
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        <location>
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    </feature>
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            <begin position="774"/>
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        <location>
            <begin position="947"/>
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    </feature>
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        <location>
            <begin position="1005"/>
            <end position="1017"/>
        </location>
    </feature>
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        <location>
            <begin position="1036"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1164"/>
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    </feature>
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        <location>
            <begin position="1333"/>
            <end position="1362"/>
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    </feature>
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        <location>
            <begin position="1587"/>
            <end position="1598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035828607.1"/>
        </source>
    </evidence>
    <sequence length="1755" mass="195320" checksum="19480B3FEC13B65D" modified="2025-10-08" version="1">MPVDRRKNKAVEKTEWIPPIHNYTIDLTLLTESEEAMLNDVIERDLAISKSVDSRVSKLKKEIQAIRVAGALSPGDDQNAICARCKYKFWSYVCPWADHGKRCYSCKFKVCKKCRFLQSNGLFLCSLCLKQRQEKWLTGEWFNPGIVGGLVGSDLLQASIRDKEYYAGLHSSRKNRNDQEEKKPEKSTPSPWKSLLTKIEIENHGSMTPVAQEDLAGGEDKEDKDKKDGKEKKKSSKKTAGKSKDDKKKKKKKKKKKKKRKKKVQGVKEKKKDGKKKEKGEKGKGKKRKDKNASHKDDNENKNEYFEEANGSHPDKEVHSSGRLRGRSGHRRRKAKHRHRDRSDSDDQNYVARAHALDYSSVPTVAALEKTNHFRCEGEGDHHVNQLPSLFCGAGEKLSFVKKQQQKVFSRSKCSKALQLPVNHCADSKSRVTGENVLLPSSLVSICKEDTMPICNGSDGADDAYKQMWLQDKKQKEAAPPKKLTAEDTDCHTNRSRSRKLSCREHDSLTRNVDMNKPCNIKDISRSPGERERELDYKSVQMRDHVFEGKPCLKSSSLKASGDFDERHHSRGADTPLSSEKYQGKNQIMASREQKAINTSTVSSLLTLLPSDMNYNFQPAARREKTPQRQPGSHGGKKRRRLPAVHPDNAGEKSVDRESTTKMAKQKAMDEKTKLVSAQRRSSYSHALENQKVSVILPPGNDNWTDLHAPVAESQSSLNVDSDEEKIDSSEPEVDSLTSSFRSGSSVATANLDTSSADTKSMSGISVHSEERNSGQQPSYSDEGNRVNSINQVEHPNSLSSIHRQQMLDSSHHGNGVVCDPAEPKSSADSFEEVYNSNVSRLMEMMTGAPLEASSLEADTTGPGSKHKRELPRTPKNGKSKELLLQKSLSLSEEVAASEELLKSERDSEKGFNDDDRLSFNALAESSSKYEAQSAGKEKYEKRSLPVVTSSTSQLNHKQPVPVKSSLPVQPRSEHGEGDQCDLDIQEIKDQVLPVSPQHQQVKGQMEEMIERTDHGEAGSSKVKPAPKYTLPQQVKEQKEELSRTSEHAVPDSLKVSLCRSGSSVSDSLSIITEVSEPCGEAECLPDQQDSDSDDTLYEGSLDSLSDEDEYYCKDFKAPSDGDILADMTSQSLGHGSDSEKELESSVASRETTESGRDINSVEELFRLTEDEQHNRNSDILSSHKSDKTDIKSKLSTKSVTFAVDECDESLSDSSRVDVEEMLEDDEEGGEGGAEINCPSVGIDLGIPQHGQEKPTLLSLAGGESYSQPQSLPVASVDLDGSAPFQRGHIGVGGDGVTTNTNSALTGGQQPQNQISLSDLGPSSEESTRDSDSGVTSSHTSRTNTPEQRQSLAPQHAKSQPSRLPLPSISVTNSGEERDGEEDDDIDELFSQHHPNMLGSRSSLADSRESIYSVYSNAGEVNYGRIPVTGDIKLHLSYDYKAKVMGVHIKACRDLAPVDTKHNRSDPYVKTYLLPDKTRGSKRKTKIKKHTLNPTFDEVLKYPISKTELESRSLWITVWHNDRFGRNDFLGEVTIPMDYYRFEENSPTWYTLQERVAPEDTSLMTYKGDLFISLKYVTADMMEASNKKKSGSSRKSKAKDKDSKSQAGLGEVHALIREAQNLTAMRAAAGSNSFCKGYLLPDERHSSKQKTPVIKKTTNPKWSHTLVFEGVDQDQLHLHGLELTIWDQEKLSSNDFLGGVRLNLGEGSYQGKVVDWMDAHSEEAEVWRSMINHPNEWIDAQLPLRASMGKQNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2Y7</accession>
    <name>A0ABM1W2Y7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prickle planar cell polarity protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101864492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829030.1">
        <property type="nucleotide sequence ID" value="XM_035973137.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864492"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09827">
        <property type="entry name" value="PET_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033723">
        <property type="entry name" value="PET_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF20">
        <property type="entry name" value="PROTEIN ESPINAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PET" evidence="3">
        <location>
            <begin position="114"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829030.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27329" checksum="B9C3D3F6E673761F" modified="2025-10-08" version="1">MATGGGSPCPEVAPEGAKRKVTHRNNPLLSDDPTIRDYTSAVNANNGPRVGDKGQGLTDTSRGCSKCGQCPGLSVHYWRKICRHCKCPPEVHDMSVGGDEAGGGASRGAGRASRDPKRNSTSDDDSGCPLEEFAWVPPGLQPEQVHLYFSCLPEERVPYLNSVGEKNRIRQLLQQLPPHDNEVRYCHALSEEERHELRMFSAQRKRDALGRGSVRIMGQDAADAACYQCEQSVSSGDLGVLASRMEPPACW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4F7</accession>
    <name>A0ABM1W4F7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118479059</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118479059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829550.1">
        <property type="nucleotide sequence ID" value="XM_035973657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118479059"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829550.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="28967" checksum="37913FC31CAE62DC" modified="2025-10-08" version="1">MDYVTGWMLDAFNMSKTAARGLLSGLTTSDRLSARIAELEAELEAAKTNQGNAEVRSSSSGLGSLGMCRQHVCAACLKPSYTCVQLEGSSVDPEDYIGLFPESSSPCSARLLSSSKSNSGTHSHGPAVSEVSSFVSEKAKGKEYAPPDMLAVGGTLLPEITVEALRSVKLKRTGGPDLRSRINENGNLSAKVKPLAPSNQPVVTLAALQRVSLRKTSHVVKSHGDCVEDDLSRKENENSGDGTMVDIRKVLKRTTLQRSPGGTPMTSKRTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I819</accession>
    <name>Q8I819_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC100533297 precursor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100533297</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="25614" last="25622">
            <title>Characterization of Aplysia enticin and temptin, two novel water-borne protein pheromones that act in concert with attractin to stimulate mate attraction.</title>
            <authorList>
                <person name="Cummins S.F."/>
                <person name="Nichols A.E."/>
                <person name="Amare A."/>
                <person name="Hummon A.B."/>
                <person name="Sweedler J.V."/>
                <person name="Nagle G.T."/>
            </authorList>
            <dbReference type="PubMed" id="15054104"/>
            <dbReference type="DOI" id="10.1074/jbc.M313585200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="7">Albumen gland</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AY162289">
        <property type="protein sequence ID" value="AAN83921.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191525.1">
        <property type="nucleotide sequence ID" value="NM_001204596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I819"/>
    <dbReference type="SMR" id="Q8I819"/>
    <dbReference type="GeneID" id="100533297"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24003">
        <property type="entry name" value="ASKHA_NBD_GDA1_CD39_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6 9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004308460" evidence="6 9">
        <location>
            <begin position="17"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="186"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAN83921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="NP_001191525.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47633" checksum="ED76E6FD28F04735" modified="2003-03-01" version="1">MLYLAVALLVVVSVGGLSLPQQHVEYGVMFDAGSTGTRVRIYSYTWDNSVPLGIKNMVQVSSMKVRPGLSSLLNNVSGIQNYLQPLMDMASSSVPKAQQAETPILFMATAGMRFEPQDESEKVLDEVRRLFRHPSFNPFNYTQPNVQVLSGEEEGVYAWVALNYILGYFDSIKPVNETAGIMEMGGGSTQIAFIPEDQPYEGEYSVILAKRKFDLYVHSYLNYGTNGIQRQVAEELVRIQEPDNPCVLKGDSKSFLLQKGSYVQMNGTGEPNFCELLLWPLIEPEYGIECEPKPCAIKNQYMPELPSIPFYALQGFAYAAKDLGVLGEESSLDLRKMLENGTEYCRQTLQEAIAAGASLEYASQNCLISLYTPLLLEGVYNVREVNQLKAPLDINGRRIEWAMGALIVDISEMKTGIYSAVSPRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAD0</accession>
    <name>A0ABM0JAD0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polycomb group RING finger protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005089103.1">
        <property type="nucleotide sequence ID" value="XM_005089046.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846928"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17081">
        <property type="entry name" value="RAWUL_PCGF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF29">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089103.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28089" checksum="AB25B2590077F659" modified="2025-10-08" version="1">MDETIKICIQDINPHVVCSLCRGYFIDATTITECLHTFCKSCIVKYLMSCKHCPQCKLKVHETHPLFLLRPDRTLQDIVYKLIPNLFENEELRREEFNKSRGMAVDKKPGTRAEEPVTPKLSSVINNPDGHLYKNDEQICLCLERYRSQRIMHRGKVLALRPLDRKFLRCSIRVLVSHLKAMLYKKLLIPPEVQVEVICDREVLSDEVSMKQIFLMNWFGKETPMVLFYRFRETPGNSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAP4</accession>
    <name>A0ABM0JAP4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">USP6 N-terminal-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089324.2">
        <property type="nucleotide sequence ID" value="XM_005089267.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857074"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF19">
        <property type="entry name" value="USP6 N-TERMINAL-LIKE PROTEIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="101"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005089324.2"/>
        </source>
    </evidence>
    <sequence length="859" mass="97434" checksum="2733C5690AC842B8" modified="2025-10-08" version="1">MSDYEEIKRASKERADIVAKYDLGREEGAQIDPWEDPAFEVYHVTDRYGFIHDSALPKNVDAAEEKAKQVENERTTKWLKMVKSWDKYYPGEKLTRRVYKGIPDCLRGEVWSKLLNIPKVKAEQENIYEKMRNRARTKSTSIRQIDLDVNRTYRNHIMFRERYGVKQQALFHVLAAYSVYNTEVGYCQGMSEIAALLLMYLNEEEAFWGLSQLFISPKHTMHGFFMHGFPKLLRFQEHHDTVLKKFLPKIRRHMERHEMYPTLYTIKWFLQCFLDRTPFHLTLRLWDVHMLEGDLVLVAMAYCIIKVHKRRIMKMQMDELLTFFQSSLEKDFVYDDDTVIEQLQICIEELKKAKMASPPKAKVNENPTLPFGLEIQPSVEQLIGKKSEETVDEHFRKNAPRTGGKAAYLRRKNTGGSISGANNLLSTPELSRSRGDSRSLHSRLSQYSIDDKSSYYDTATNSRISLADFSARTSAPSSRTSFGESSEMGSMSAIHAHGFTSPIDLDDVGVDMATPTTPTNPPLPAQDYAPSNSPPPVMSQSYEMARPSSHSQAHQQTAVIRSSASYELPPQANVISRLEHSPRQVVSSYEHTPQPRPPPARDSQRTNSAVLASRDGGTRWSGLSHDHHQRMRNTRSYEMDSGSSFPPPPPPPPPPPAEEVEMHTPRQSASFEQDQQRTSRTSSSSPYEQAVSRQSPSPGHSFSPMILHASTAVEDRPPSAVTGEDNDSTKSPGSVASDYDNINGMYEDSQEDARSPSFIRGDGVTVIPVSKSDGFVSSTQDSEIIILNGHDGAMTAQMKMTRTEGDIQRVLQQDRTDSRHVDFHNGYQIEQQNSYQMSEATTSQTRTMYSRVVEKTAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAW3</accession>
    <name>A0ABM0JAW3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pituitary tumor-transforming gene 1 protein-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089476.1">
        <property type="nucleotide sequence ID" value="XM_005089419.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851457"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052304">
        <property type="entry name" value="PTTG1IP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15191:SF3">
        <property type="entry name" value="PITUITARY TUMOR-TRANSFORMING GENE PROTEIN-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15191">
        <property type="entry name" value="PROTEIN CBG20567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045156945" evidence="3">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005089476.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23772" checksum="91E369BA3ADBB12A" modified="2025-10-08" version="1">MEMKSVKVSAYLCGLMLALFVAQALGAGSSTSASSTLSSTPAPSTEMSTTKKSSAAPATTATTTPSATTLSPKDQCKQYNGSCDKCVSDAKCMYCYTDDSCQLYPAGDVLPPSTMCALDEARWGVCWLNFEALIISVSVIGGVIILTIVVCCIYCCCCRGKNKKKFEREDARYEQQKMERKTKQDERRSERKSRLDEIRRKYGLVKDEAPYQRFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JB30</accession>
    <name>A0ABM0JB30_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">E3 ubiquitin-protein ligase TRIM56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101848790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089573.1">
        <property type="nucleotide sequence ID" value="XM_005089516.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825054.1">
        <property type="nucleotide sequence ID" value="XM_035969161.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848790"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF299">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825054.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50343" checksum="80A8DDB6A84BA069" modified="2025-10-08" version="1">MDSEKIERLRERLLQCAVCMDEYKDPRILPCHHTLCFECIESVVQSSSASGRFFRCPQCRSDVCVPRGGVGDMPINFYIISLQDELGAKGYAGNCDICERDWLVSQFRCIDCDLDICRFCIHAHRLETHTEPPKILRIEAKANTFQFASNRVCREHADEILQMFCCTCHEAICVTCSCGDHKRHNVVPITVKLQESKTYLQAELDRLTTEKRSAVKVAELIQKTKEEVVEVSNRSMLALDAAAHRACAAIMNRKSELNKQILHSEKGQVNSIADAMNDFKLYTQRLDRGLAFLSDLQDNDICLEVVDTYKDFSNKMESMRKTFASNHVRLQHNIFTASDHTNTIKLPGGLSDHFIFYGKLGHMSWKSFCLSIDPRSLTVTKRLRGVSRLSESVIVKRFAQCIFAFIVCQFILFIWDTTGAYDLINSQFCALLLVLSNMLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBS7</accession>
    <name>A0ABM0JBS7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein LOC101848158 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC101848158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090026.1">
        <property type="nucleotide sequence ID" value="XM_005089969.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090027.1">
        <property type="nucleotide sequence ID" value="XM_005089970.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848158"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005090026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090027.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53801" checksum="FAEA60CA5E082767" modified="2025-10-08" version="1">MGNTESRASGVPMSVLHAEIAALNQGESCEMEILPSTNKDDCDGEFECLALQRFNRCPKKSEHNQFVPILELRLEHLPISVRCPTVLKLIKDVAVITVRLIISYTSNDRPKRFRCGGGFRVGSGYVDRKGSVNQWRGSHVGTTFIIQTAAHVVFNNREAEKTTVEFFYEDDYDRSSVVRAKGVSVLLVNEKKDYCQLICQVENLHMGAKVMQRLSKDEDYSSDNSPMPSRIDLAFCISHPHGTAKKVSLGTTKLVKVKKPVFKSAVLKALLYGCCHMSGFDEKKVMYFYFTEIIKLEIGDFFSPTFVSEFALHKTAVLTRLQSKGLICRPTDTEQELIQREFDEQLLIYKVLMEAQFRRTYGSQTLSSADKEAKKIVILKEIVGNLESKLNAPDSVMEIHKNMFEEIMLVITEVMYGQQIPVNSCTTVESATYSVPTCSGSSGAQVNALVLNSSGFKFLSATHSFGGANLENRSGFGSFLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDH9</accession>
    <name>A0ABM0JDH9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LYR motif-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101851173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091192.1">
        <property type="nucleotide sequence ID" value="XM_005091135.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851173"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="7">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005091192.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9724" checksum="994DB51D52EC46B6" modified="2025-10-08" version="1">MSQLTLKQFMLRSEVLKLYRDLLRITFKVENPSYRKQLQEWIRSDFEMNRHHTEEEVIKMMVSRGKLSLREVEQAVLLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDU5</accession>
    <name>A0ABM0JDU5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101855998</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005091402.1">
        <property type="nucleotide sequence ID" value="XM_005091345.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855998"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005091402.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41151" checksum="B6776AA456DAFABD" modified="2025-10-08" version="1">MGASITRTDFEWSYTEEPHASRRKEMLAKYPEMKKLMGSDPRFKYIVTAMVILQLLVCYAMKDQSWITVLAFAYIFGGTINHSLTLAIHEIAHNLAFGHGRPLTNRFFGFFVNLPIGVPMSISFKKYHLDHHRYQGDEEKDVDIPSYMETKLFTRTLYKFVWVCLQPWFYSIRPFFINPKPLGALEAFNIVLQFAFDYLLWYNWGIKALAYLVVGSFMATSLHPMAGHFISEHYMFVKGYETYSYYGPLNWLTWNVGYHNEHHDFPSIPGSRLPQVREIAPEYYDNLPCHHSWVKVIWDFILDPEIGPYSRVKRPSDKKMNGNGATHKENGFSSTKENGGTHQNGVKAANGKCHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE13</accession>
    <name>A0ABM0JE13_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101850134 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091549.1">
        <property type="nucleotide sequence ID" value="XM_005091492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850134"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091549.1"/>
        </source>
    </evidence>
    <sequence length="910" mass="98836" checksum="4F9D1CA759D68638" modified="2025-10-08" version="1">MQLLRTNRLRLSDLNVPEGVSSIGQSRTGERHTGRVGRSEFAKFKPRLPTAVEVEENVDTAAGVGESSWDLSWFDSAELSASLEDCLEIPAPDAFEYSEGQSEVERSTENCNDMVSHPSAPASLATPVLSKAEPLIDSLNYSQPSEVEFPQSVIEEAPATNVEREKSDTSKQFLGIDFKKASLTCSDEMMVPQAQDKRVVNEDRQSLKDFDPVRDECDNQLEPPANVEIEFEKSSASTRITHLDVPEELMCSENLVAVKDLRSVRGGTLPEISEDDVSNEVPTIKTGVDFEHWGRDSEFSSVIENKVGEGDSEEDLENYFEAHVNAERPAGHKDSGYEKGGEMVGLVGGTVEEVMESGLSGIGEDEVKEKETGEESPTKSVAVAEDEVEVFVLAEDNKDSVCFEESLHGTGWDTAQSSAGHQVSSEREDQECPVESGRDLRPPFENQIGLSQATSCGDPEQSSLDSGIDVKVALNVEAPSSQESNDVDVNIRVCVEAPADEHQEHCFGMLKIETGLSDHVEQQSSSGGDELMLKSSSFIAAFEEEVKAIFSRHDEPDGHEIEESGSEASADDSGLKCDRVLNTMFEHDVAVDGNEMSFSKSSSVPAVAPLHINFENSADLSLPVGMPGHCAAEQREVMSAKKSEEAYFKCSDVITGDQMRLPDGDGDLLCNAVEQLETTEEEEEDSVLSSRKNSLQIYTSGDPKVVANKKFTIKVSALDPKVETSDSQQPQATPLRDASFSSASQTDVEDAFEQPKGQEEFGTDGPSQLGTSGEMAVVASCSFQEGHNKRTTFTSNIQLGSGTAGIAFDIAVQKTSTPQGSDSNAELGNSSDFSWNFQRNLQCKRGIPPMGSSSVSQSESSGHLAFRRAHEVTLSDLYACAVSFLDVFFWICIGIGLLIYECCMNSSRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE25</accession>
    <name>A0ABM0JE25_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091563.1">
        <property type="nucleotide sequence ID" value="XM_005091506.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852985"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF19">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="532"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="606"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="701"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="620"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005091563.1"/>
        </source>
    </evidence>
    <sequence length="730" mass="81852" checksum="4B53B5C9D142CBC6" modified="2025-10-08" version="1">MTAAVTTPASTAVERQLKTLCLREFPCGLGAWREPGPDAQQYRPTRRGRLRVKPLQHQQKSDTDSLDSIKTHAQKEKSESLQELVSSHFSPWHLDYSWSEEAKKLREIAVKSPWLIDQNFVLNYFKTLRIVDKNVSEVDHDLLMLKNLEELTLSANFITNVNSKNLPPSLRVLELCANQISDVSGLCVRPPLLHHLGIGHNKISFIGDYITGDFWPNLLSLDLSHNDLCDLMDIVRKMTTLPRLRNLILQGNPLSLIPGYRGYTIDSLRRLSVMDDIHISADEKHHFKGLSRRREFILDEARVQISVSYIKGLPCPEEIKNPEGQPEFPVVERTYFVQFMFPEEPEVRPAEDDGAVDDMADLTALEMEAAAAAGEHQDDPSEHSPTRIGSSNKSAVETPAPLERNVQINSRPEVKSVAPPASYSVASFPRANPNPDPEVLPGSEVEGISLDFVDESQVGEGEDGQTARQEEAEPTPRIKLAPVNTEPQPWGEELELNWMADLTRDDLLGLRDFFKQGMDFSVVEQVVLGYPAEPDTSSEKTDGKDGKDKKKAEVTPKGKNSAKDKKKKKEPEIELVKSPATYTTIATFHITLDQFLEGEFEYHNIFTKGDVPPPSTIRSIDPEDKKVEKKDSKDKKKPDKAADKKKDQNANAKKSPRGKEADKKGAKGKHAEEAEEEDLPPPPLELEVSVKLHHWVTAMDSVREEEEKNRALQEAKGKGPQSRKESLKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE93</accession>
    <name>A0ABM0JE93_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101848721</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091709.1">
        <property type="nucleotide sequence ID" value="XM_005091652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848721"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091709.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="33713" checksum="7B879BE43A247AF8" modified="2025-10-08" version="1">MGVEGLLCQVYGPDVSVAWREFLLSMVLLVIGLLMLAFCIAAQKMEEAAGTNLTIPFSSQQQNQKHVYNYKLEPTEQLSQVLSNRRKPERFGLGPVGDLSISPFTIDPRNILKRPVSGLSSDLDLDITKHIQKSQPTTAAATSPQVRKEPDTLNAPPPSPTIPKLTTTQADEENANTSIGLDLATAAYGLIPPAPSLNTSFIRGNYSSLELASSVWLCALVEVASAVPESVVLNITLSTLVLLFLLYATQINIPSVVTTLLILAMKRYIVDHVVRPYRSIHLPSEVDSDISINSLSDDTESFVTVAGKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEJ5</accession>
    <name>A0ABM0JEJ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101857544 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091929.1">
        <property type="nucleotide sequence ID" value="XM_005091872.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857544"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091929.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="40700" checksum="65B8C76C1C87D7BB" modified="2025-10-08" version="1">MLCWRRRCLRTVAVLLLVLFLTGFFFTSYHVFYTLELLPWNPPVSQWCKNEEISPALWQPVEKEMTIVTMFIDLGVFKKGDQPLSYHSPYKYRRWMRTFGKIANHVVAFIEKDEDVEYFREIRSCLPPRLTKVIKVNREELPSFKHLSRIAEIYADPSYPKHYPNTVSAEYTCAMHAKYDALEKASTDDTFKNPYIAWVDVGLFRNLDGTKYRPFKLIPPQTFDKTAVGFSYVWPQRSESSVHTIMRQNLVWLAGGLVLAKREVMLKFTQDYQAAVEELLHRGLSNTDQEVIASMYSPEMLKEDYIKVQTFRCDQGQMGLFGPDARYLCLGYLCRHEWQKREMGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JER0</accession>
    <name>A0ABM0JER0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101845903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092049.1">
        <property type="nucleotide sequence ID" value="XM_005091992.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845903"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028001">
        <property type="entry name" value="SAXO5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34828">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34828:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15373">
        <property type="entry name" value="SAXO5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092049.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="55504" checksum="ED8F6E9BFDAACEBB" modified="2025-10-08" version="1">MAQKTQANAAVPRKQDFNRGHLGSNNFSIGHDFSVTKSTLQSVFKKDFPEHGTYGRADLAKPPRLGDVMHIDDRFNERASETVKAFEYQSIPKPVLLDVANKLSHTNFKMDSDTSKINSFHTTHNHFFKPKMGDTFSPLQQIQTTQVSSVPQGDREKAEKPISDYKYKFTGIDTTKNRVERARCMHDDGPPTIKGDNRLGHFTSVSRTQFQGDWAPKVPILPVPPSYNVPVGDPDKEKTKWSVMQSSYDDYTDALKSHTPFDTQGVSSKLRKTNYKERDGHGVWDSYETTMTSAFPAKTVDLSRSSPSKHRNESDFPPGDREAIRDKERMSLTTSRFYHGSPALGLHNRIVSGANRRTQSNVWFGDPDLDKRYYSTSTKEVFQPKRVPYSYDRQSHYIPSSIPIDYCRNSMTYEATTSTDFPDPRQERMVPNAKALESLQSSHIKPPQKHMTFNTTHQDEFVPKPLQNFVYDSGRLQRSSVPLGTMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFP8</accession>
    <name>A0ABM0JFP8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane protein GPR180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101854550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005092610.1">
        <property type="nucleotide sequence ID" value="XM_005092553.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854550"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053880">
        <property type="entry name" value="GPR180-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF29">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21870">
        <property type="entry name" value="GP180_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180-like N-terminal" evidence="8">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180/TMEM145 transmembrane" evidence="7">
        <location>
            <begin position="190"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005092610.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51303" checksum="41D0C7CAB774F9BE" modified="2025-10-08" version="1">MAKTLRPMNNGAALWSGGSIKRLVYVAATLFLWIPSLHCKTVSGVFNTYVAQAGRGQYVTSFAFHGDAVLTFTVNSTGTEANLHLFVSEDWKDAAGDTNCHRRLAKAKELISINETSGSRPVSHYVYPRIWHIVYSDVYTCDTNRPVSPVEKPNFIHYTLQLFNPDSIGNPTEHFGDQETGLLKFYQLLTVIYFAVACVVAPQLYQTLSKGGPMQLVIQLLTFSMSLQAVGVLIFVVHFYRYSHDGVGSPYLELSSEFLDMLSQFAVLFMLLSLSLGWSLASAHSVCRYSHLRDMSRKPAARVVAVLGLVQGLMFMWEQSQDVNRRMYHAQRSYAGISLVLLRILLAAMFAVKLKELIRSERSSLKRQFYSSFTKLCMMWFLCYPFIIVLSWMFSEYLRYKLITMGVLVCQSVAGVLLYRLFLSRSLYWEVSALSSTLPLRFDPRFGMKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGE5</accession>
    <name>A0ABM0JGE5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor-like protein 8A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093121.1">
        <property type="nucleotide sequence ID" value="XM_005093064.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854151"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005093121.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21448" checksum="BE44F514CF21C3CF" modified="2025-10-08" version="1">MLSFFQRILDWFKSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKISKGNVTIKLWDIGGQPRFRSMWERYCRGVNAIVYMVDAADHDKLEASRNELHNLLDKPQLQGIPVLVLGNKRDLQGALDERELIERMNLSAIQDREICCYSISCKEKENIDITLQWLIQHSKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHR2</accession>
    <name>A0ABM0JHR2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC101856790</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101856790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005093925.1">
        <property type="nucleotide sequence ID" value="XM_005093868.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856790"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="852"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="967"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1170"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1261"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="969"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1191"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1268"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1296"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005093925.1"/>
        </source>
    </evidence>
    <sequence length="1593" mass="173271" checksum="5EE700F6B4B55FF2" modified="2025-10-08" version="1">MMSLSEEESQSVHENNFESDTETEERNKDVKASQESSCEDHVQTLGISDQSAASKQAKKSEKAPKPKVKIKTLTIDGQLVYFCKICDKIFTRRKDKLNHELAHSGESVLTCTECGKEYLHESSLASHMRTHSADQLHMCELCPKMFAQSHHLKTHILSHSEPNDFTCKTCYVEFATAVELNHHIRTEIKLEISYYWCKMCKVYCCRNHGLQCDKNLHAYQCSACNELFFTNKKLRIHMKKFAHHSVQKPKFIEPLKEHELYRGKCVDGNKKSSVQGDKENVTRKQIVYGNSNLNKRFASDDLENELPPKRFKLSPRKLCVEVDNSSTSMQESAPEMKIEFKSEIRSPVKQRKGKPYCKRCNKSFKDTHDLDRHKVQIHEEKQSAASCEICGMEFASKDELAKHSTKHSGERMHACPMCGKEFLHLIHLTKHLRSHTGDFPYKCSTCKKAFRLKIQLIQHVRLHVAQDTNACDKCTAKFTSKQELQEHMVQAHGEPDCFKCHLCSKTFSFRYKLINHLRLHTNVKCFQCYICHKSFATKHYLQRHLQIHIKQGMEVDVKNIIVDQDSKTELDHSHDQQERCVGDTWSTAEGQRVLEKHCAGVKRGEEVLPKSQPENSDSKCISENFESRSTFVSESASNSRNYDLNCTHIKTEPVDRDSSSEHSVCSSLTRHSDKSDPFRFSSDGSTSFKTTMAKERIRIRRRWKKMHLARKAKALQNVEKAALELKKETVFSEVKIEDENENGDEAADYPPTDMVVELNGVCSEVDNVLTLYVDVTEKKPPLLPMKQDASVIAALESPEKVSASNKLNDDVAFSNALVLDIDISDSDLDALKCGYKSFSSLDKSISVSVASSNTTSTSELQGKSVDSSKSEATPSQFLSESLPQDTLCFPTDLGKKEVNAVREKTHSNRKNEKPQVPSVVVPTVAGTLKSGAASKDNYSSQAKTGKTGHDVEVSCIPASAQKMVSRSATSSKLLSPGKTSLPLPSSSKSVSGSAQSNPERSGIIYPATPAPTPLSQMQAMICMNLGNIQHSTKSLTSSRQSVVTTAADTASKTLQLVPSSSVSLASHLLTPPVSSGLQVPRTPALSTPSASSVLSNFHSPHKLSVSSCTSMVRGQHATQFTTCPLSIAPKTFNFSAHSSMAPLTSQFSTHECSVAPQFTSQSAPLAPVVQQLSGPPSLPPLLPGPPAAPHTQHQTVPTPASSYIPTSSLSSLHIPVPSSHSSGSAFHGVGIAPSHSFSVPMQTLPPAPIFTSLGSSNMDSLGGVTLNPPQLLSGPGPSLAGVPSSLGPPSGLPSLQQAASGNVDSNPFTLAPPATIDTNNPVLRNMNMMDLVSPSGGSNSFNVAVPGPTPDLMRSSFNTLRQGPAGILEPQSSVLQPGHLLNVSSRNLGGVNIGSQGLSSFSSASNIHQLPGAFNPVPGGYMHNSLLSTGQGMSGDPLSNARNMPNILPDPSLNFLNSVQNASLGFPVAHPVGPTANSAFPFGQLGAATFAPTPAPAPTINFGGLTIPSVDTRMPSINSGILDPSVFSMGASRHPLPGPPTLGMLDVQRFAAPGLHFDVPRVVDTNFVASQLGLAGAVNPTFLPTNMTNFPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIX0</accession>
    <name>A0ABM0JIX0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101852990</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005094707.1">
        <property type="nucleotide sequence ID" value="XM_005094650.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852990"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CAP-Gly" evidence="16">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="16">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="533"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005094707.1"/>
        </source>
    </evidence>
    <sequence length="915" mass="103605" checksum="AFED86231C276DF0" modified="2025-10-08" version="1">MSEVGHDCCFILLETKYGRKKDLHRPSSKDKIEVLPGTLLILINRAVEKGMVDLLLETFDTDKSIQVNCYPGEVEDISSAVVDLLRPIPTCHERLEVFRDTEWIQDGQRLRVGDWVFVKLKGVQEELKGILRYKGSEFPDSKGILFGVQLEEAKGNCDGMYRKKRFFKTEQDCAVFIPLHKIRRQRDDWHKNARLRATEDSNKRSRDDSSNYGLKIGERVVWMSDIGAEKGVVKWIGTLPGESDDSNVTVGVEFDNPVGTGTGKYNDHRLFYTQPKHASLIPLMGLMKEEEFENGSSNAEPVIQELNSSPAFISQQQKLLDEIGGRSRPERPPKNCYLENHSVMKSYDMPNYSGDKLNTSGARSADVARSYPISHSQEAACMNPYERSRLQDDLAATSSSGSKSSSSGFSREADPDLDVGSMVEVAMKTPHYGVIRWISEPNPNGKRTAGLEMEEEVNGATDGTFKLVRYFTCAPKKALFVPLYKCSKDKRFATERKISSDFGGKPTPDVPGDVAPPDLTTEAEFRQICGKHHGIQGHHNSCYLDATLFCMFYFTTVFDFIFNRQPRPGDLPQYPEVQRVLKDGIVNPLRKFNYVRADKVLKLRSLLDKLATVEGMMSEEKDPEEFLSALLTDIMKADPLLHLSSGEHTYFYQLFMEKDDKLLLPTTQKLVELSFLQGNVKLKKVPSCLMIQMPRFGKDYKMFHRIVPSLQLDITDILENFPRDCIVCGSLATNECKDCYQVHGPGLNTTAFCDNCVRRSHQHASRRNHEPQKIPGAANFLPVYERMKEEALMKASRNGEANNGDVAISLPREVMELFAVICIQTSHYVSFVKCGTGPGARWVFFDSMADRMGEQSGYNIPEVVHVPDMSNWLDERNLSLLLQKADDKDLPEHLRRILCDGYMCMYQSPNVMMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ47</accession>
    <name>A0ABM0JJ47_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094831.2">
        <property type="nucleotide sequence ID" value="XM_005094774.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860798"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094831.2"/>
        </source>
    </evidence>
    <sequence length="592" mass="68479" checksum="3802F7057A69853B" modified="2025-10-08" version="1">MPNRPKKEKTATKTTGSAKATGKETSDNGDNEAKKKAQQPNTAETHPPPTAISKMKYPGPPHIKRDKRQNSSRFNVSKNRELQKLPLLKDATPAEREELFIQKIRQCCVLFDFVQDPLSDLKWKEVKRAALNEMVEYVTQNRGVITEAIYPEVIHMFSGNLFRTLPPSSNPSGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNTAKRYIDQKFVLQLLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRKHINNIFYSFVYETERHNGIAELLEILGSIINGFALPLKEEHKTFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDPSLTEQVIMGLLKFWPKVHSPKEVMFLNELEEILDVIEPAEFTKVMEPLFKQLAKCVSSPHFQVAERALYYWNNEYILSLISDNVGTVLPLMFPALYKTQQHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKVERQKEKEKHRQRDDAWNKINNLAQDNPQYKSVMRSPVGSGSPGSSLSPAPNSTEEDGDLMVTMEKLEAEAKDAKNSIIQKKKKEKPLLRRKSELPHDMSMIKALESHKRSDEFLITSSEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJT8</accession>
    <name>A0ABM0JJT8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein NATD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101856878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NATD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095333.1">
        <property type="nucleotide sequence ID" value="XM_005095276.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856878"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435:SF9">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005095333.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25684" checksum="9FD05184EBD5D7FF" modified="2025-10-08" version="1">MNKVFQTLCKQQLNAIRLVTKFNAATLNDLRNYSWCCRNGNVVACENWLKIRGKKEKERKVLQSRLVARFTVPVSSVTGPFAFHIDSRSLCLGRPQQDKRLQDSGVVTEEWNLSENMAGYIVGHDKSNKMFYITLQAKPENGETALAKLEYDYVRPNLVDLYHTEVPPEFQGQGIAKILAQTAFDHFCEQEIRFRPTCTYLQKYLRTNPVPRYMDFMDKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJV6</accession>
    <name>A0ABM0JJV6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional repressor NF-X1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095362.1">
        <property type="nucleotide sequence ID" value="XM_005095305.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863660"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047354735" evidence="2">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095362.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17507" checksum="CFE52801E7E207DC" modified="2025-10-08" version="1">MYKFAVLAFALCVAIVYSQTSCSTDQDCHPSPCHDAHVASCNSDTKQCECDGGNNHQDNHNNNDHHNNHNNHNNHEPAVGKRATSCSADHDCHPPVCGNSHHGVCQNGQCDCDAAHGHQQSHFHIRAHSANCTSDDECVTLCGKDHAKCHHDNMCHCDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKX0</accession>
    <name>A0ABM0JKX0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101864681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096118.1">
        <property type="nucleotide sequence ID" value="XM_005096061.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864681"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17602">
        <property type="entry name" value="RIBOSOME BIOGENESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17602:SF4">
        <property type="entry name" value="RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005096118.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38421" checksum="C2C807DF6C6DBC33" modified="2025-10-08" version="1">MAATQSVVDSILSTTDDSKFKTIQVDSAELIELDEGNLLAVNENKVDTKEFRKRTEEILLSSTRDATQCLFNSLWQLPVEQVEGAYVVKLPEPKTWLPREKPVPKKKPLTKWQEYAKSKGILNKKKSRMVWDELSQEYKPRWGYKRANDDTQEWAIEVPDNADPMEDQFAKRKNAKKERVAKNELQRLRNIARSQKSKVPGVGLTPTEKPSKDQLSKALAVAHKSTASIGKFTDRLPKEKPSRFTGKKRKFEPSIGNLKSEKEKQLNLIETNAKKLPKIDMAKATNRALRQEEQTASREKQSRKTPKKAKGKKALGLGKKASGGRTGGGNKKTRGKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMQ9</accession>
    <name>A0ABM0JMQ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101863262</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101863262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097310.1">
        <property type="nucleotide sequence ID" value="XM_005097253.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863262"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332">
        <property type="entry name" value="PROTEIN CBG11604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047000562" evidence="4">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005097310.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="17894" checksum="B936FC552F952A99" modified="2025-10-08" version="1">MTSLDLPGPAVTAVLGLVCALMAVAEAIDCYKCTSINGKNEGCEDKFDTGISTVELIARNCVYGFFKGTHCIKLKGEKEDGTRITVRDCSDGDWGSHCGDIRYVYGNQEQKIYGCLEACDQDGCNSAISLRPSFVVVTLLVSISIVLLTRLQSPSLLSERGAHSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNZ4</accession>
    <name>A0ABM0JNZ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger MYND domain-containing protein 15 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098126.1">
        <property type="nucleotide sequence ID" value="XM_005098069.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852691"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042989">
        <property type="entry name" value="ZMY15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47085">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47085:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="2">
        <location>
            <begin position="479"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098126.1"/>
        </source>
    </evidence>
    <sequence length="706" mass="80119" checksum="25EC07E1D0F259C0" modified="2025-10-08" version="1">MNEENSSRPSSGQLCSAKNTDGDGTDCGSDEHGSGSVVATCEPLRGNANECPAAVVLVTENDKQSSKADESSLRNKPDEDCMVDGRSNCEKNDNPFDVDEPHMPCNCNLKPNYVCHLSDDPNEEGEQQTLEQKMSTLTDRTATALAPDPMDMTVLKALEAAGCVKKMALLRQKCKDQKQQWQQVRELPVQDALWIIGEYENVCYEEHRDDHVLRVMAVFEVHGNTKHLLGTSIGWSKIMNFKTQLLQLLCCACLEPLVKAPRRPRFLRIKASPQSRGLNLNLKGVGIHVFSPLVTDSAIANAQNHISDKMWFRSCHGCGRRGTSEMFTSCPDCDAVLFCDAYCRDYSDHSKWCPYFKVYMETEETLGEFPLAFTNETTQRLYNVFKNRDFLMRHNIYNKGIWRRECKLLMVSLMAFGFGELDWPSVEPYGLSKEDAILKHPPQRSIPSLSRPLTDWACYYDYRGFDHDSPVAGVLHYALTLYRIIVHQLPLNYPAVFNKMKQEMFLCVHVIGAAKEADMWHSFLECARLLRPISLHICFIGNEISPDAHDSFKGEENLCVRCFSGLYHELQRYPMFPEGHIAVCFNAGLGAYGTYKKTVQHLMSTGMPSFCTDYCLASYEQSRKTVRVQRMAVLSEPMLNPFRSPFRMVFTDTDLPRYSNAILFNLLPYSATTAPMVFVPRSFCKNHSKQECTSEVYKLSLLPDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRS1</accession>
    <name>A0ABM0JRS1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Prostaglandin reductase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 8" type="primary">LOC101845245</name>
        <name evidence="4 7" type="synonym">LOC101845003</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100049.1">
        <property type="nucleotide sequence ID" value="XM_005099992.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005100050.1">
        <property type="nucleotide sequence ID" value="XM_005099993.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005100051.1">
        <property type="nucleotide sequence ID" value="XM_005099994.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938898.1">
        <property type="nucleotide sequence ID" value="XM_013083444.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826082.1">
        <property type="nucleotide sequence ID" value="XM_035970189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845003"/>
    <dbReference type="GeneID" id="101845245"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08250">
        <property type="entry name" value="Mgc45594_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="18"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005100051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012938898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826082.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="36665" checksum="9CC32CD20B773481" modified="2025-10-08" version="1">MALPATAKQVTITKLGTNFREVTEIRDVPVPKPQAGQVLVKNKFVGINASDINLSSGRYDPTMKPPFPAGLEGIGPIVAVGEGVTNLKIGQAVAFLQFGTFAEYVIVPADKAVPVPSTDPGLLSIVLSGLTASISLEQKGNLKAGETVLVTAAAGGTGQFAVQIAKLAGCHVIGTCSSPEKVDFLKSIGCDRVINYKKENFEEVIKKEYSNKLDVVYECVGKEMFDVSLQNLAIEGRLIVIGAISGYENAEGTNASEMISKLPVGMACLRKSASVLGFFLPHYVKKFPLHIATLAKQYAEGKIKVNLDKGENVANGPFKGLEKTVDAVEHMFSRKNIGKVIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS82</accession>
    <name>A0ABM0JS82_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101851196</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="RefSeq" id="XP_005100330.1">
        <property type="nucleotide sequence ID" value="XM_005100273.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851196"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 14 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="248"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1543"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1550"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1576"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1613"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1955"/>
            <end position="1965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005100330.1"/>
        </source>
    </evidence>
    <sequence length="1977" mass="217772" checksum="60A5044C4613A8DC" modified="2025-10-08" version="1">MTVAAGYTGDSNAPLRDVKKVQFGILSPEETRRMSVTDNGGIKYPETMEGGRPKLGGLMDPRQGVIDRQSRCQTCAGNMTECPGHFGHIELAKPVFHVAFLTKTIKILRCVCFFCSKLLMDPTHPKMKDILIKSKSYPQKRLAHVYNLCKGRKICEGGDEMDRKKDENLMNEENPEENAHKSHGGCGRYQPSIKRNGLELIAEWKHINEESQERKITVSAERVLEVFKRITDEECIVLGMDPKWARPDWMIVTVFPVPPLPVRPAVVMFGSARNQDDLTHKLSDIVKANNQLRRNEQNGAAAHIILEDTKMLQYHCATLVDNEMPGLPKAVQKSGRPLKSVKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLRVDQVGVPRTIAQNMTFPELVTPFNIDRMQSLVQRGANQYPGAKYIVRDNGERIDLRFHPKASDIYLQYGYKVERHMVDDDVVVFNRQPTLHKMSMMCHRVKVLPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETKAEIFNLAAVPRMIITPQANRPVMGIVQDTLCAVRKMTKRDVFITRAQMMNLLMFLPTWDGRVPQPAILKPQPLWTGKQLFSLIIPGRVNCIRTHSTHPDSEDNGPYKWISPGDTRVLVEDAELVSGIVCKKTLGTSAGSLVHIVFLEMGYEIAGEFYGNIQTVINNWLLLEGHSIGIGDTIADQQTYQDIQDTIRNAKNDVIEVIEKAHNDELEPTPGNTLRQTFENQVNKILNAARDKTGSKAQQSLSEFNNFKAMVVSGSKGSKINISQVIACVGQQNVEGKRIPFGFKYRTLPHFIKDDYGPESRGFVENSYLAGLTPSEFYFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVKYDGTVRNQVEQLVQLRYGEDGLDACWVEFQALPTLKPADETFKRKFRFDATNERAMRKCLQEDVIKDLMGDASLMAELEQEWEQLQEDRVGIRQVFPTGDSRIVLPCNMNRILWNAQKIFRINKRKPSDLHPLKVIEGVRELCSKLIIVVGDDPISHQANENATLLMKALIRSTLCTKRVAEEHCLTAEAFEWVLGEIETKFQQAMAHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKEIINISKKPKTPSLTVYLLGQAARDAEKCKDVLCRLEHTTLRRVTANTAIYYDPDPMNTVIAEDQEWVSIYYEMPDFDASRISPWLLRIELDRKRMTDKKLTMEQISEKIQTGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKYQDEDEVVDKMEDDVFLRCIEANLLSDMSLQGLEAIAKVYMHLPTTDDKKRIQITDDGEFKSITEWILETDGTSLTKVLSERDVDPVRTYTNDIIEVFDTLGIEAVRKAIEREMNHVISFDGSYVNYRHLALMCDIMTSKGHLMAITRHGINRQETGALARCSFEETVDILMEAASHAEIDPMKGVSENIMLGQLAKVGTGCFDLLLDAEKCKYGMEIPTNLGPGMLGGAGTGMFFGSGGSPTSSMSPLMTPWGQVGTPGYASAWSPGVGSGMTPGGAGFSPSGASEAGLSPGGYSPWSPQPGSPGSPSSPYIPSPRGIQSPSYSPASPSYMPSSPAVPTPQSPSYSPTSPSYSPSSPGYSPASPKYSPASPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPASPGYSPTSPSYSPSSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPSYSPSSPSYSPASPNYSPSSPSYSPASPKYSPSSPSYSPTSPSYSPSSPQYSPSSPKYSPASPQYSPSSPQYSPASPSYSPSSPKYSPTSPRYSPASPDYSPSSPQYSPTSPSYSPSSPNYSPASPSYSPSSPQYSPTGATSSPVSPSYSPSSPAYSPNTPHYSPTSPHYGTDLEDEDDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSM1</accession>
    <name>A0ABM0JSM1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosylation factor-like protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100564.1">
        <property type="nucleotide sequence ID" value="XM_005100507.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845334"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04157">
        <property type="entry name" value="Arl6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041839">
        <property type="entry name" value="Arl6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005100564.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21717" checksum="2DCE39B0BA94DD8D" modified="2025-10-08" version="1">MGFFDSLAQWLGVRKKEVNVMVLGLDNSGKTTVINHFKPPETKNHDIVPTVGFNVEKFKSKSLAFTAFDMSGQGRYRNLWEQYYKECDGIIFVIDSSDKLRMVVAKDELDLLLQHSELKNRRIPVLFFANKMDVRDAVTSVKCSHLMGLENLSDKPWHICASNALTGEGLHEGVDWLTDQLKEVLERKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSV5</accession>
    <name>A0ABM0JSV5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100704.1">
        <property type="nucleotide sequence ID" value="XM_005100647.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857256"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005100704.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16104" checksum="96C9939FA9AA76F7" modified="2025-10-08" version="1">MAPRRGKPQQQEQVVLGPQAKEGENVFGVAHIYASFNDTFVHVTDLSGKETIARVTGGMKVKADRDEASPYAAMLAAQDVAERCKTLGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSW5</accession>
    <name>A0ABM0JSW5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100731.1">
        <property type="nucleotide sequence ID" value="XM_005100674.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864304"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403">
        <property type="entry name" value="LOC100145250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403:SF6">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100731.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17713" checksum="C4FEAC85147C324B" modified="2025-10-08" version="1">MCEEIQIRTARHEDYDDIMEIGDVYGGRDYLPSMFHMFLDDPNIYAIVAEVDCKPVGFYLLHVLDGGESAVKRGGRVNTSFRKRGIFHLMTESLNQKLLSIEPPVKRLSFSTTNFVDRAAGEFTDEGYVEVLRKDFNIDHRHTSWRGAFTEDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUN0</accession>
    <name>A0ABM0JUN0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC101858871</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101899.1">
        <property type="nucleotide sequence ID" value="XM_005101842.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826535.1">
        <property type="nucleotide sequence ID" value="XM_035970642.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826536.1">
        <property type="nucleotide sequence ID" value="XM_035970643.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858871"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22932">
        <property type="entry name" value="HFD_TAF6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF22">
        <property type="entry name" value="TAF6-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="10">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="596"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="488"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="745"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005101899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035826535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035826536.1"/>
        </source>
    </evidence>
    <sequence length="871" mass="99044" checksum="F5FFBD35B440D21A" modified="2025-10-08" version="1">MEEKTYAVFTAESVNAMAEKAGMSPVPHEAAAALGEDASYRMRQVIMLATQYMKHSKRRRLSVDDFNRAAKELGVMPVCGHGSQEPAPFRLVKDQDVYCVDDPEVSLCDIALGTSVPKNIGLPSIKAHWLAVEGTIKIWSGGSSASQGKGNREMSPTHLNYYNCMTKALLSQKAEAKKKALLDLKRNPNIVPMLPYLVNFVISGIKNMSHDMGHLTTMLNTIRALLHNRSLYLMHKPYLATMVQGVEFCVLEPLAASISSSNDQWVLRDYAARLLAEIVNRWNSPQNHLRYNTIKCLREALYDTSKPFYSHYGAVMAFIALGHKAVEDVVVPYLATYWPHLKAAMEDRAREKIVNRCDSHKVYGALRLAAEKILRRHVSLFKDLATARKERREVAEVLDIDENETALAPDSVESTNATVTATKKSPQKSVFELYKELYEYFGDSLAHCLPVVETHEVFRPMPREERVELGDANTGKSGEELLDNLMEQIYLEEKLEQERKERELVEQKEREKRERQRLAREAILRKKKEEEEKVKRQKREEDEQRRLLELDQQKRLREEEERRRKEWEEQIKELNKNRSKPEWQQEIELRRIQLEEEMQYSRKMEAKKRQEGRVRTDEEHKVKKPKLEEDMGKDDDEDQAGRSRAGLRRRKPVNYTEKDEDISDLFEDKPLAMPRQIPRLNPALPPHSDISDFSDEDMKKATSSPAEGLAVSKVIDPSKGLLKLKIKRASTHSSTPPHPMSATPQHTPSSYHSPSMQSPMYSPLSGSHSTPPPPPSSSMHHRSKSSSGSEKESKHKKGSGGGWRQSRGGSAGFQDISDPEEIFYEKPLGSLPPQLYSPGAESSGSDSNPHRKALKLKLKLTPKESASEGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV08</accession>
    <name>A0ABM0JV08_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859946</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102156.1">
        <property type="nucleotide sequence ID" value="XM_005102099.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859946"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1280"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1380"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1601"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1776"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1310"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1380"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1650"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1667"/>
            <end position="1684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005102156.1"/>
        </source>
    </evidence>
    <sequence length="1841" mass="199267" checksum="16273A1C6420CA33" modified="2025-10-08" version="1">MENFHHAHMGYARTEQSGPDDLQRFLVTSQHATHGVFRYPAQKEAHINAGSQHKMQTPPIHNFPSAAPPLYPNPQSASLQKQQQQQLYNGQDQFARLCPVSSARQTASAYGQNSSYGQSFAYQSCTPPSPVSQESMWMSAAQRSPQLSPAMSVVQQPLNAHPSICSTQSSSVPYSPSVQAPPPMAHMHYPQTNNYVPSQGTSYLHDGQFPQTQQPAPQVSHQNMLSPHQSNPISQLAHQSLTSNILTQNAYQTAKSAYDRHVSSVTLKETAHIPSAVQPDPQQSFINTYLGQFSSAQTAVTMSQQHRIPDPVSARSQVSSAHPQRSTVGGLPVSSSVPVPTGAAYSRPAKQNLKARQGHPSSRGAPAAPAAPSLNIAARLLHPVNAATQFAMWDQSTRKQPQPQPQPQPQPPAAHSQMPQTVHRAAHANNQRVQSIPQRSSAREMENFVRTRQQPHERTNAERAAGPRLAVQSARGRGRALGGVARGRGAPLGRGRGTVNSAPTENVMPLQWYRQPDLNLSSEYQSDIEAMRGSTASDARQRNTQLAQQIPKPTSSGTTSQPSTSTSAAPVIQGDAQSSSHTRMSKAASLAAIEIKQEMVESMSRTKTGTDRDCVRKDCAASHHKDTSSGSSSSNQSISLASRQPVAPQRNAAQSNAPGDPSCLQNGKQPMVHPSIVKQERHEQETESRLAHVSGPVPSAQGSSSSSSSSSAPRGGGNAAPSDRSRDVPPQVRGGNATVAPAGSVNSFNSPPPSAFGPEQGAAGNRMNVPPMPGPRSVHTGPPADVKPGVNAREKVFSMWRAGQVVGRAPVRGKARVKATTVRPPIGKEGREANDLPGAPQVRDGPVERRQNNNERNPHVAAAQGQSSVNSMKNLDTSSSACLPAGSQTSRFVPPPSLTAGDTQNAPAANSVSERPACEPNKSKKAYFYATLHGHKLLCLQSGDRPFVLVCQFQFQCFTDIGVGSVTNCIDRALRIKKRLLDHPEKNKILLYLKNNGYLQGPGAENFVYTISVDDARRVYHCMYNIRNCSSDSCLMELTSVPVDFNAVLPAMKKREMLKKIKKEKAEDKSYGRLSSLSQQRNLKSYTPAPHAKLNKSNGSLSNRTNAESDTDTTAQNDSTVEYGNRDQANSLETASGTAGDKNLITWSGQEAKVGRLLNTVVGQVRSYQDKGENFLVVDDVSRILGKEEFYKVVDIENITLYSCCDEIHSFLNGISLLFPPISSVKNCLVKEKDIGTEASGDVRPPELNGSSDSERKRVLCKEEVSDDFCSTPKQAKLSETAEQNCGDAPSNNNSFTDIEMGSSFVGSEGNVSAASVRTSPRGSDCEMDSSGEGRLHIVFDKSPPSSERSNDKEICSPVKTMADRVILSSLASEQNWNSLPTFTSESLPSSTSESLPQDSSGRELAKASSKERLSRDEMNSVSLLSGAKSPDASFPNLPTAHENLERTESISVRDNFLFDKDDGTPVNRYSDVSEHAASEPHSPDVVLVSAHFESNSGVMLPKLEPAEEDTRPQNKEKDGDVQIEPSVFKAHGLKLRNMLQETQRTLASLVSGEGKGSDTVAHCPVTQSLSSFTESSSINSVSESSSMSVSQAQENVPDNFLSPWQVAPSPRKGDAASSSAKNTKQTKEIVAVQESPSHFLQRSDEKRFSSPPRSSEVQESQSSHSTPRSVPSCSQSALPQTQNKSREETDLGGNRNLVLVDGFRVEVVMKKEIEDSGSQCTSEMMSTSAMAATPDVLPALSANAPSERRSQDDINVKTTEGCCEWRSQRAILEENNKLKLQVRSLTETLKQLQSEFSKSKEEVKSLQHVKTYYEDVINDITSSFKNGDEETPIFINDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV65</accession>
    <name>A0ABM0JV65_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Fatty acid desaturase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC101845629</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102265.1">
        <property type="nucleotide sequence ID" value="XM_005102208.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005102266.1">
        <property type="nucleotide sequence ID" value="XM_005102209.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005102267.1">
        <property type="nucleotide sequence ID" value="XM_005102210.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845629"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF13">
        <property type="entry name" value="FATTY ACID DESATURASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="105"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005102265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005102266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005102267.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42630" checksum="D4A81AF37D6AEE06" modified="2025-10-08" version="1">MTQQPVTTCQPPAENGTHPVSRINGKKSPPSLSVKEVDEKTGVVTDFVDLQKLPEFQILNQRVSAVVQSSSWWERYGVDMFILLGAVAGLYLSYFCLASSDGIVFAAGIILLGLCHTLISVKSGHNAVHGSLCSSPFLNKYLGYFCSDFVGSFSSDAGYDIHIKCHHPHTNIIGLGDSSTFRAPFVPNFLYMFVTPLLSPFLIPLVSVREMYTKSAVKIVRHVIVAYGGFAFHLYLLTTVSQLTIWSALLVCFLSRNILSIPYIHVNIFQHIGLPMYSQQYRPKKVYQMTTGVLNLPRNFVLDYCFGHGIISCHVEHHLFPKLSDNMCLKVKSVVENFCKEYDLPYHYDTYINRTKAFLFDYQRLMVNAPPVTKFVGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVX7</accession>
    <name>A0ABM0JVX7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101857731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102772.1">
        <property type="nucleotide sequence ID" value="XM_005102715.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857731"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005102772.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11053" checksum="8070EC6873FA9768" modified="2025-10-08" version="1">MVCDKCQKKLGKVITPDPWKAGARNTTEGGGRKIGENKALSSRKNRFNPYSSSFEKCRICKTTVHQPGSHYCQGCAYKKGICAMCGKKVLETANYRQSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXZ1</accession>
    <name>A0ABM0JXZ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Enoyl-CoA delta isomerase 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005104180.1">
        <property type="nucleotide sequence ID" value="XM_005104123.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850899"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00435">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="5">
        <location>
            <begin position="240"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005104180.1"/>
        </source>
    </evidence>
    <sequence length="592" mass="66623" checksum="C8A390B242F0CA48" modified="2025-10-08" version="1">MSSKTAKYREKMKREDPEKWAAYREKQRKDAKERRDAKKLKWETQPHTKDMVAEKKREQENARLRWRRLQERRRGEGSGVLKIEQSSPTHNGCPEKRPKEMTEEERRAHRGELRRQSRARQTPQKKRWAKVKNAEYQRKYNERQRELKGLHAARPSSRPAPSPPPLSPTSGSPLPSISPGLPFPSTSPCLPLPPTPSLLSHGPSRLFDALDLWRISWNVGVKQLSGRCFHASAVCARPAHDAKFEGAKERLNTLSEAPGNDVKLKMYALFKQATKGKNTTPKPGMMDIVGKAKWSAWSELGDMSQDDAQLAYISIVDELLGAEAESAAAAEDAGPGVQYEGLKIIREGKIFKIQLNRPKKYNALTHDMYRGIAAALAEAAEDKACSVAVLTGAGDYYCSGNDLSNFTNVTPDQIPKMAKDARYILIDFVRAFIDFPKPLISLVNGPAVGISVTTLGLCDAVYCSDKATFQTPFSNLGQSPEACSSYTFPKIMGPAKANELLIFNKKINAQEAFDRNLVSEVIPHDKFQEETAKRIEQYSKFPPQSMRLSKVLNRSSELETLRRVNEAEAELLEERWQSQECMNAIMAFFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYJ2</accession>
    <name>A0ABM0JYJ2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101855438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104545.1">
        <property type="nucleotide sequence ID" value="XM_005104488.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855438"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="65"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="491"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="644"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005104545.1"/>
        </source>
    </evidence>
    <sequence length="692" mass="80202" checksum="4E11CBEFFCF418EB" modified="2025-10-08" version="1">MSSKAVAKSVQFASNLPQLQNLMKRDPQSYKDEFLKQWQYFHTLMQAFQLQPTKYNEKLDEMISFVAQVSHCYKEEVGDLPEQLGDILRNHSTVLDRTIRMTLIKALIMLRNKNLISATQILQLFFKLLRCEDKLLRKTIYQYIVSDIKNINAKHKNAKLNSALQNYMFSMLQENSAITVKTALDIMTELYRRNIWNDAKTVNVITTACFSKITKVMVAALKFFLGKDETEEKEESDSDDEEPKKKTKELSLGHRVAKKTKKRKKKLDRALEAVKKHKKKKTSVEAFNFSALHLIYDPQGFCEKLFRQVEKTTERFEVKLMMVDLISRLIGIHKLIVLNFYPFMKRFLQPHQREVTRLLLYLAQGSHEVVPPEAIEEVLKTVANNFIAERNSSEVMAVGLNAVREICVRCPLAMSEDLLQDLVQYKSHRDKAVMMAARSLIQLFRKTNPHLLHRKDRGRPTEAQTELKVLQYGEHDATSFVPGAEVIPETEEKEQTKNQDQDGWESCSDEDDDSDGEWVDVYHSSDEEQDKDKEISPEALEEKRKLAEEISTTRIMTDEDFKAISHNQISKDITTAKSQTGSRKRKRPEAFGETDKELPKLGDIEMVHKKKLHDKESRLATVVAGREGREKFAHGPQKMNPFASTSNKEKAKKKAFTMVKHKIRRKKVKRSFKEKQVALRNSLLKRHKNARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ38</accession>
    <name>A0ABM0JZ38_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104937.1">
        <property type="nucleotide sequence ID" value="XM_005104880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845185"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104937.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="27388" checksum="4FD4A059F654ECE2" modified="2025-10-08" version="1">MANCTVASPRSSRLPVAASTGRGSSGIPSPQISRTGLGRSSASHDKKTLHSVIAVSPKNSRVGGGGGGVGGGGIGGGGRNRTTGSAAAGNKGTHSASSTPTLSRRVPPPSTLPAADNSKKREGNKTIESSPPPTKFIPSPSTASSPSSSSLSNITVTSVCPPTTTTSSSEPGKPRGTGSSEPEKTRGTGSSEPGKPRGAGSSEPDKTRGTGLPASASTGSRSAVGESSNKPPGVTNGVNSQLSDGRNRVTISGLTRPSGVVSHECGGTGYSHSGGPLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZF2</accession>
    <name>A0ABM0JZF2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101856678</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105152.1">
        <property type="nucleotide sequence ID" value="XM_005105095.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856678"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF13">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="3">
        <location>
            <begin position="613"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105152.1"/>
        </source>
    </evidence>
    <sequence length="730" mass="82621" checksum="90C25265332579F3" modified="2025-10-08" version="1">MDVIHRKNPRRWALMVFALFGIYVFVKLLPKPEWICNDSQIADHSPVVNFALEPYLQRLFFEQTSTAKPVENYYIDTDSNYVISMFPLYKGLKHVPVPEREETHNDVKDDPEVHVHVFFLRNLNFTNFGRTWSNEVPHFTKPPNDDDQGSPRAKRSYRPRPRKSPRSRIGDSNLLNFPKSGDTGANSGNDPKFRSKGAYSGNDPKFRSKGANSGNDPKFRSKGANSVKDPEFGKDTDSVNGPKFRGRGTNLGNDRPSAYNGVNTQNGRNRNRDIPQVQKQREDLPDCVPLRVPPDTPPTRICVHSPRVDNMISNGIRDTGEWEGEHVANMREFFQKHPHSQLVDLGCNVGVFSMSAASLGLPVLAVDILPANLALLRLSMAFNDATGDGYDLENRSLLDYIREHPEREEHKGNESLLANSSGVYRDSSSGVYRDRQTDHNITAKPRDSARIFNENRRPKYSELITTLHNAVYNRRRKMVVYFPDHLNLGGTEVHELTPVPPKPSKQSGQNAILRKIRSVTEDVALSPSLSGAGRHKRTVDRGGRGGFKQSQKEKLSGKHLRPDRYNKKAGSLKISSSWLKLKDTQSAVVKANPSPHADVVSGSNIEEKVKVRTDAATREKNSRTGFVVDAVCLDDLIPYLRHGRAVFLKMDVEGSESKILRCASRFFMEVDVRVILMEMIFHKHTPEGKQMVLYLQQHYMLPSADVSGKNLLDPDHLLYWPPNVYWLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0M2</accession>
    <name>A0ABM0K0M2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101861385</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105954.2">
        <property type="nucleotide sequence ID" value="XM_005105897.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861385"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1619"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1699"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1869"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1956"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2181"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1360"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1619"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1699"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1883"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1896"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2193"/>
            <end position="2212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105954.2"/>
        </source>
    </evidence>
    <sequence length="2342" mass="262391" checksum="0D9EE72C2C41112F" modified="2025-10-08" version="1">MDLDDDSYVDSYFYNSHQHSSSILGAVFEGLRNAQLRFYNQALSLASVVDTIVLNSIEAVKGSGPSFDFEAARLKPQAHSAAFSGMPFVGVICSGNGCKAVLVSLVTFVFTLGIFSVATYVYLKQRNRAAQMFLMKVQNGRQPVQDSHPSQTKAASDTCTEKHPEVQDAEEVSLIATDAKPLPNQGQRSAIRLGIEGDTGEKNSEKLSRNVSFCHELENAKPAMNKGVAPKVAKKTGKQLKTKMKLFTEKIPATKRRIYATKSTPSVTQPFKVISAPSKPTPCNRSKLGAARSKTQMFSRLSPSPKTRFRGGGFSRTSVPDLDSHVSSNVSSRSQSAPRCRPHVRQPARVSRDLSVSQKAFSSTTLPGSFRIDMLAKSLKAQQKSLAPDKSTTKRSPVKPSQQTIKLKESKSKICMQRRRDHKVKKSPGSASLERKQSLTSHVQRKKLARKPNLDRISNANVGKIRRPFRLNTKNVVSSSKSSNNTLIKSRDLGETMISQTKKGKHGECRLQQQTETKKSNNQYYPTSQKAGASNISALFSSRKTNGEDYLLPNCLVRPVATREKTGNEGKNFPGNFRIRKTETPELKSLTGEGAFTSYSKTEHFDLNGSFCPATGEFYKSVNKEAVRTNTFHKLTMAEEDCKGKLGVIGVTSEMHCETPKHAQANHMTASGQDKPQQLATEMADINVNSWLGFWPEQGRGDKSTRDFLTESTGGKHTCFPNQETSNRCSKCNLFLKTKDNWSLSPTILTHKSDMRVTRKELKRQYGNIKDGPGHISLQPWPARKMTHQCRHPVYPSRSKEGQDQQPTPANIFSHVCEAQLSTREFESHLDNGQSNTDTLFDRHSNSVKHTDTTASSGDTEKDTHRAVYHTLCFGSDGYPRVVPRETRSHEQKCCFTYDNKIRDYPYIIKGTTTKHKSRKENLNFSLRSCPNSHKAKSHPNSLSRHRVKMCRSGCRQSIRGTRKRGLELSEDDVLNVLESDLARPRRLLKAKRVKEEKERESQGQQPKPHPLGHSISLQYMLHELHDLAHTKHATPRSSKDFYGYFRRCEKPETWPWYPTSNESFTTAKRYQDKPETGSRAHRYHHRCHRLRSHRHEPYKMDTASSSSSSAYAHSQRKLNKNNCSPCKEKRFVVLPHMGRAPASEPDFSLEIDMNENPGYDCRHVVASGVSEVGSEMYHDPYGDSSAGSRPARLADRERITKLLWPHGKNCQPDSGQQGEEVKVKEQERCHFRLPYDWRSVSHIRARRGSRQNNDSLRSNHRFKGNALCLARKATFSPETTEHRRNQQKRYIKNRLPKGNNKIWDIRDQKETGFNHIQRYKIHSIQTDSIRNVPTDVDKNPSTSARSTKTENISQNVEASSKSKSSISKHVGVQTSPTLNSTKIEIKAAKNMKTRSLLPKLICNKLHRPMKPRPFLRRQRSSIPRRVSVVRLEEKEVISDSRKESMLSLPRSPEHSGKALNSGAIDFMKPAYDKYTTEFETSKKNTDNESEELTFVNKPVMTGKVIGTKTEMDINGSLQMPPENLKTSEVVMNSADHTRKSFPESIQRSKEQSNADNDVKDCSNHMLPHPGKDKETVLANKSHQKNVKIPKDVQEGTGLCSLVEEEDSTLLNRTYSIRNTSPTTYSRPNATPKKISESNTFHPLSGLQNICLIRPMWQNADVTELDRRVRRALRLREELQQCKMNKQNTSTAQIITQISECKNSDTSESPATEDLRPSDTDEIPSCQLDATSSFHQFSSSNIARRENCSLSPTNASTLQNEVIGFEKTQPQREIIENVTDSVEQGGHYSIDGNFTSGIESFNNTDVVAQFIGNKSMEHQKAHDFFVQEQAGDDKAEMSGEGAVNDDFPVDGLDELSRRVGRSGSFHYILHQPVTQRPERPSSAHISSKPSNSGHCGLKRLGHKQKNSPPTKISKVDNAATPGGSRLVGQLVKSLPHVPLLSFVEWFIETSDPRNFIDSGKSSSSSNPGNDRDRTTSPKAGITRSQDTSPTKVPFQRPREKDKNLEELLSVSYKTAPNLHSKHIATPFLKPQPTGLNSFESFRYEKNRDIDSSHLSVTPTTPTNVKIIGEPTDRKCNKDALRIGQYTPEKQPPKSKARKIRHIMNPNVDDIIRPIRSHRQRRYTVTKSLFPPSSLQGSETPSYETVPKMSLEPAAKCQMNKENGEVSNGFDSKKAICTGNSEEPRVAHTPLPNEASSNQNWAPKSSPLANGTAQHPDGIAKILTSFEPTEHMTESLNAVQLTEQNIVGTFSSPGKSLEDRPAVPAMQLFLGSQLYQPTESAECKETADKCAPGIRQILMKLRNVKDTGDSATVAQPDRMRITLRKSSDVTGIIAKFQGTGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0S2</accession>
    <name>A0ABM0K0S2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuropeptides B/W receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101863926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005106049.1">
        <property type="nucleotide sequence ID" value="XM_005105992.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863926"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="84"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005106049.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="48680" checksum="0A8B7727FCA6AD86" modified="2025-10-08" version="1">MASMLSDRIPVLNIATNMSTTTSLQQQQQPSLAQLDLFDPTNASATMSCGGQNVSDHYKEFYMMAQFITGLIVYPILCIIGITGNVLALVVLNHRDMRTSTNVYLSSLAVSDTFKLLNDAMYVIIVAISQSDQDLSEKFMSSLYPVAHYVFNMSVCVTSWLTVSVAVERYISVCYASRAKQLCTIPRARFVCTFVFIFMSILAIPSGLRYEMITIQDHTLNTTCVEIVPTTLGNNEAFMKPWSWIQNSLRGIIPVFILVYLNVRIINELRKERVKGKKFSARNRITLMLIVIVFMFLVCITPDAIMSTFFGKGYVEEDHLVKGIREITDSLLAVNSAFSFFLYCTMSVVFRTTFVKIFWPFPRKPGDGEAIQLTCTNASSTAAKKQQQQKQQQQQLQQNTTTTADHVGLVNSSQVVRANGCSHAAEDGAGKEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1A2</accession>
    <name>A0ABM0K1A2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Frizzled-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101846026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106398.1">
        <property type="nucleotide sequence ID" value="XM_005106341.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846026"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FZ" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005106398.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14031" checksum="CB5A0886D93606EE" modified="2025-10-08" version="1">MDHSCSKNTRLLACSMYLPKCTRRGPPIGPCKRTCMTARRKCARPLNRMLGLTWGDKFSCRTLPNRRCLKPVRDRRCRYQHPNCVSNSPLNVCANLTFTWGTLPNMYHQCHLDVRTSNIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1F4</accession>
    <name>A0ABM0K1F4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Barrier-to-autointegration factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005106507.1">
        <property type="nucleotide sequence ID" value="XM_005106450.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850506"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051387">
        <property type="entry name" value="BAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004122">
        <property type="entry name" value="BAF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507">
        <property type="entry name" value="BARRIER TO AUTOINTEGRATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507:SF6">
        <property type="entry name" value="BARRIER-TO-AUTOINTEGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02961">
        <property type="entry name" value="SAM_BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01023">
        <property type="entry name" value="BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106507.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10281" checksum="154A045998C2F12B" modified="2025-10-08" version="1">MSSTSKKHQNFVTEPMGEKMVTELAGIGDVLGGRLSDRSYDKAYTVLGQYLLFKKSEELFKDWLIEICGANKKQANDCYQCLKEWCDSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1X0</accession>
    <name>A0ABM0K1X0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6 7 8" type="primary">LOC101859038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106808.1">
        <property type="nucleotide sequence ID" value="XM_005106751.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827884.1">
        <property type="nucleotide sequence ID" value="XM_035971991.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827885.1">
        <property type="nucleotide sequence ID" value="XM_035971992.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827886.1">
        <property type="nucleotide sequence ID" value="XM_035971993.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827887.1">
        <property type="nucleotide sequence ID" value="XM_035971994.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827888.1">
        <property type="nucleotide sequence ID" value="XM_035971995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859038"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035827886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827888.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="36802" checksum="AB3C932C329D37C5" modified="2025-10-08" version="1">MDEQNCVVAPNPERTPIFSFARLRRCATMDDHEKQKYEASEKKTSSSSMSSLHNTLTSILNSKSNNSATGVGSPPHGTGSFYPYSASAPLSGLASPERTKPGMAELAQSKLASKHTEYKSYSRARHSSSSSSSSSFSSSPKSTPTSTPTNTASPKVFPPHPLSKTPRSALTFNANVKEKPVFRRYLSLIVFPSSLKQIPFTVPTSPHGPANRTGFRKAEHRSLDEPSTSGRSEPTSPTGKRPSVEIPGAYALGSIDPSLYKVADEDDHYDIPADHIGRVWFATEYERETEKLLVTLIKAKNLPSRTQGVDNACDPFVRYVWRFMFTFCRTQESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K338</accession>
    <name>A0ABM0K338_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hillarin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107641.1">
        <property type="nucleotide sequence ID" value="XM_005107584.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856462"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="120"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107641.1"/>
        </source>
    </evidence>
    <sequence length="832" mass="93978" checksum="7F7A7E44E0B93C41" modified="2025-10-08" version="1">MGCGSSKGDGGGGAKNDNPPIDGIDVPDLDPKYPAPKPPENTKDDIFKPADFTAIDNKAKQMARTNASSYDAVSRALTANCTTDLQKARAIFVWLFHQNIHGSFYSGVTDPHTPRGYMKLIKTGKGSYATFFALLCREANIPCNVIRGVSKGDNYEVGQQNVKGMDGAWNAVYLAGSWRFVHPLWAYYKEKQAYEFGQPPPAGTKRVSINEFYWLTDPMKMICFHNPKAEPWQLLKSKWDQKKFLDSPQFTEDYFKSGLMLPRKYNAIIYSDNGICIIDLDHQAFEDLRVDATVIKDVNQSQGENTSPDLNMGDYVTVASSSTRKSAIIRFPEKGRYNADVYGGKLTSETQRPLKIVEFRLECSESAREPVPFPLNPRDGFGILPAANQMGISDPNPDSGLVLVKQGQQKTFSFTTTQRLEAEATLVHYHNTDSRDFHSYISTRTTEDTLTVDVIVPDEKLLEFGLEIAARPEGGGRSFVTVANYLLVDENWKKRTAVVSPTRGASKSELERIRQALITATGKTDIAKLENAVEEFERNSMPDLGDLTRARQRLVELHLANLKKTTRDRKLEDLERAIDAAKKSHVADQLVDTKEMADAEAARRQLKRLKLYMHKVMELNKATISEIHSYQRPRPLVQKVMQATFRLLGEPNKKIQDWSHIQNSMRRLGRNSMISRMRRRDIVDIKEPQVNDAERYLGETNKILVRMCSAGAGTFYVWSNNMISEHQGKGTLDPTNIWGRTSKEDPYSRKSKGGSVQNSPRKEKLVESWNFKDSTPRGQHYHNDPGRYSPHNEENTNIKSRRNEGWGSNTQPSGKQQDTVSDDWDPNRRSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K377</accession>
    <name>A0ABM0K377_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101854980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005107724.1">
        <property type="nucleotide sequence ID" value="XM_005107667.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854980"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005107724.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35377" checksum="AB2510C8FC09C76C" modified="2025-10-08" version="1">MPKERAQKKSRIHQQVAQVQRQGISFRTEIGQHILKNPMIVTSMVEKAALRPTDVVLEVGPGTGNMTVRLLEKVKKVVACEVDPRMVAEIHKRVQGTPEAPKLQVMVGDVLKTELPFFDVCVANLPYQISSPFTFKLLLHRPFFRSAVLMFQREFAQRLVAQPGDKLYCRLSVNTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPRNPPPPINFKEWDGLIRICFSRKNKTIGASFKFSKVLEILEKNYRVSCSVRNIPVPEDFNVKDRVVELLQKGGFEEKRARSMSIDDFIELLNLFNEAGFHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3C4</accession>
    <name>A0ABM0K3C4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-Fucosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005107806.1">
        <property type="nucleotide sequence ID" value="XM_005107749.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853817"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005107806.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="42124" checksum="FD4AB5318D8A9CD3" modified="2025-10-08" version="1">MCRHGFRRLRTQKLAVLKVFFCILVLCYLLWTYWRNVVLFVRFVSQPEYRECVHRRRNYELEGRTDPLYVTLAIHGRLGNWMYGYASLIGIARANGYTPYLSPSHPLNTYFVLSNKRDEPAECLRVVYDDRPCAYNPEFMNLPNGNVSIEGYIQSWKYFKLVEHEVRKEFQLSGDFKTRVLKQFSKLVEVYIREGRTIISIHVRRGDVLKPEARKLGFCHAPKSYFDKAMKHMLDKFPHSAFLVMSDDIPWCQENLNPPKVEGKPVPIVFSPGYSMGTDFGMLTVCNHSIVSVGTFGWWGAWLANGHVVYYKDFPLPGTKIDYETVKEDFFPEHWVAISSCVTVTISHSLMCLLLVFAFRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3F9</accession>
    <name>A0ABM0K3F9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101849239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005107868.2">
        <property type="nucleotide sequence ID" value="XM_005107811.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849239"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF286">
        <property type="entry name" value="GH22266P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="424"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107868.2"/>
        </source>
    </evidence>
    <sequence length="608" mass="64051" checksum="CC88532534A3AC54" modified="2025-10-08" version="1">MASAEVGVAPDGGWGWAVAVGGFFVSFFLDGLEYSYGVLLPHLRAEFKADMSLLTFTGGLLTGVCLGMGPITAVLVVKFGCRPVAFAGGLLASLSLIVATRVPTIELFIVFYGGFTGVGIGLIYLPSITTINRYFHKKRGVVVGVATSGSGLGLLVLAILIDLLISEYGWRGCYLIIAAVYLHLCVCASLMRPLGGSHVKTADGEEEVGCSDSGGVSEGEECLVVGETRVCPDGWGDVTVGKTCPSEQCDLGTGQGQGSNYNVPVLTSTQTPHIEQTLLGKDQNDKNLLLEGSKYPRGFSGSSNKDGVNDPLPSTNHHQQMAQQILQHHSHHHKPHTHHGSLQDTSNNELLNNLPSDLLHIPPECISVSSLSIASLRSRSLQSLRAKSLNTSCTHSHLSVDQKVVVAPDVTARVSPLSLLRLAGFDLFCVGAFLIQVAASIPAMFTPSYTLSLGLDQTSAATVVSVLGIANTVGRLVAGFLAYLKVGSVRIYNTGTFLAGLACYFLPACTTYPTLLTFAVCHGFFLGAFPPLQSVILVEQLGLSLLPASLGIVCLCKSVASVVGPTLAGALFEAVGTYSVPFYFAGGILTLSTVLHCVMSFCPRPQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4P3</accession>
    <name>A0ABM0K4P3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein ALP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101862451</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108687.1">
        <property type="nucleotide sequence ID" value="XM_005108630.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862451"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="170"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108687.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45313" checksum="747D8CC0A880642E" modified="2025-10-08" version="1">MDSSSDEDIGIALALYVLSSEKRKRRFRAHPINQERERRGVMAKLYPQLCDDEDKFYNYARMSRASFEELLIAVQDDIRKQDTNFQQAISPRERLLLTLRFLATGESARSLHYQFRMGDSTVRKVVYDTCERLWEKLLDKEMPHPTETTLKEEANAFENMWQFPHCLGAVDGKHINIEIPPNSGSAFLNYNKKDFSIVLQGVADAKANFLAVDVGESGNHSDGGIFKHSSFGRALLQQQLPLPQPDAVMGEVLPYVFVADEAYPLHPNIMRPFPARGLDDRRRYFNYRLSRARRVVECAFGIMAQRWGVLKTTMRVNPDKARKIILACCILHNFVRRQQDESVDSAAEEASTDENPFQQQRSITERSMSSTGRPPQEAMEVREKFANLFVTGLAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4S9</accession>
    <name>A0ABM0K4S9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichoplein keratin filament-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC101853732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCHP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108740.1">
        <property type="nucleotide sequence ID" value="XM_005108683.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943691.1">
        <property type="nucleotide sequence ID" value="XM_013088237.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853732"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF2">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 11" id="KW-0416">Keratin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="8">
        <location>
            <begin position="145"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="79"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="379"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005108740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012943691.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="61023" checksum="30E10F60C5519D4A" modified="2025-10-08" version="1">MALPTMSGYWSSRKNMYEQAIVRHRNHEDDFRSQWQNTAKYFKTSDVRAAKQQAWSSTDAFQNKCTDAYQASVDKDVKASNLKRRRDKLANLIKEESKSYEAELRGLSKPNFERLEEMRTKADGLKSAREEKRQKLAEEKLYEHWRQNNAELRKAESQLLQEHVVGNWGDQKQEKEERLESVRRENLEFDREMERERLAAVEMERQKEEERLREEKSVKEVLKEQMMEFKAREVEAAEWKKEQEKLLQQRWELERIEENQRMREEERKRKDLGRALLRQHKAQMMRKSRVIQEELEQDRKLLESLIERESEHVALQSARKEKARADAQWMKQVLDEQLRVEKAREAELDMLYQDEAARMWQKRESEWERERQARQRLMAEVLESRQEQIGEKLEELRHQQEESLQRREELVREMEIAQQMTRREEEEKEQDKMMTRAELEEQIYSKREEAARLQRQLDLELKEENREEQDYEDLLKQETQRMRIHGYTPRDFGRRQAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4Y9</accession>
    <name>A0ABM0K4Y9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13 14" type="primary">LOC101845577</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005108873.1">
        <property type="nucleotide sequence ID" value="XM_005108816.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108874.1">
        <property type="nucleotide sequence ID" value="XM_005108817.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943772.1">
        <property type="nucleotide sequence ID" value="XM_013088318.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943775.1">
        <property type="nucleotide sequence ID" value="XM_013088321.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828411.1">
        <property type="nucleotide sequence ID" value="XM_035972518.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845577"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14515">
        <property type="entry name" value="DUSP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020405">
        <property type="entry name" value="Atypical_DUSP_subfamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682">
        <property type="entry name" value="AGAP008228-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01909">
        <property type="entry name" value="ADSPHPHTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="260"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="329"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005108873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012943772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012943775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035828411.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46090" checksum="FDDB0C73E9F41306" modified="2025-10-08" version="1">MMSIFDEDRPCSVQELQDILTAPSHGMAMMPSTAFDEVYEGIFIGEGDSAKRIGCMKRLRVTHVLNAALGKTAFHVNTNHVMYQRSNIQFLGIPATDMMNYDLSQHFQQAAEFIEAGLSCHGKVFVHCVQGVSRSATLVLAYLMIKRHMTAQDATRLVRSEREIFPNPGFLQQLCDLHEKLKRDGHFQHGWINRRNPGGAEESVARCRSPGVVDSKSAHCLESETPGRQEEDCHWGVCTVEDLEEILTEPSGGFMMLPNEPYHQIDEFIYIGSRAFAMRITELKKLGVTHILNAAQGKGCSTDASMYEPEGLQFLGVQATDASGFDISQYFTCAADYIASAVAHRGKVFVHCVEGVSRSATLVLAYYMIKQRKPVREAVCLVRSQREICPNSSFLQQLCDLDQQLSTTHPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5T1</accession>
    <name>A0ABM0K5T1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101849966</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109400.2">
        <property type="nucleotide sequence ID" value="XM_005109343.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849966"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF306">
        <property type="entry name" value="RE01051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005109400.2"/>
        </source>
    </evidence>
    <sequence length="191" mass="20622" checksum="0DEBEBA684FC026F" modified="2025-10-08" version="1">MALTACTFSVGANLISVYMASKARREGLSRPQTATLSTVQGATDLASRLSMGFIADLGFLPKSVMVSISMGVLAIACQFAHYFTDHSSMMVLACLQGLFGGARHNLQSVILIDYLGVERLAKALSVSMVVMTLTIALSHLIIGGLEEATGEFDAPFYYISAMLTVSSLVFLTEPLFRRLDQRKQMERVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K646</accession>
    <name>A0ABM0K646_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109628.1">
        <property type="nucleotide sequence ID" value="XM_005109571.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863059"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01012">
        <property type="entry name" value="YcaC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF17">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109628.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22012" checksum="8894F09BD0E1F6E8" modified="2025-10-08" version="1">MANKRLGDIDVSQTVVFVCDIQERFRNAISFFPQIAEISNRLTEATRILDIPLVVTEQYPKGLGSTVPEVNISNAVGVYPKTKFSMVLPEVEEKMKTLCGGNVKHVILCGIETHVCIQQTVIDLLKRDIEVHVVADAVSSRAQTDRLFALERFRHMGATVTTSEAILLQLVGDKDHPKFKEVQGLIKASAPDTGLINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6I8</accession>
    <name>A0ABM0K6I8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">D-ribitol-5-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101847535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109902.1">
        <property type="nucleotide sequence ID" value="XM_005109845.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005109903.1">
        <property type="nucleotide sequence ID" value="XM_005109846.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847535"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43015">
        <property type="entry name" value="D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43015:SF1">
        <property type="entry name" value="D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005109903.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="55948" checksum="2E34B06D573EF7CC" modified="2025-10-08" version="1">MEVTLTRAMVDVVIPAAGSSQRMNLPTAKQFLKVMGKHILAYTVESFHRVLWVRRIVVVAAADQVVFTRELLQSYGFTKVRVCAGNTTRHRSIHCGVKALQEDCAESDVVVIHDGARPFVPEEVLLKVTEAARVHGASGVTRPLVSTVIRGDVDLKLVESLDRRLYRNSEMPQAFQYGVIAAAYEKCSEDDLEHGTECLLLAMNYSHCHAKLVEGSEELWKVTYQKDIYSLESTIKERQTVVSILGQSSLREKVHSDLCMRLHQRNLCVVEQGDPANTFVVLVEPDEPFTNRVNLCSQIETCYAALPESAVKLGVFVLLLTHAKPQTASPGNLCASKKNATVIEGSGEENLLSSSDTVDEEPHHITIPTKTETYKCKDFSGNNITSERTSEHTRTSSNISTNVSLSCCRPPSFCGELTDQGLSTSNSTHDGESEKHNSFSLSLDCRQKGNQNLPQMIQQRLKKKGNNGCTVLQIVYSSSTETLGKLLDELIWQRGSYLDGQTLSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9F0</accession>
    <name>A0ABM0K9F0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101849580 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101849580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112048.1">
        <property type="nucleotide sequence ID" value="XM_005111991.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849580"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005112048.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54668" checksum="95C4FC07037EF7DD" modified="2025-10-08" version="1">MGNTESRDSDKPSVLPSVLQAEIASLNQGDSCELEILPIASKDVNEEEFEHFSLDRFSRCPKKSEHDHFIPVCEVGVEHLPVSARCSGILKLIKHVSKITVRLTICYTAEDRPKQFRCGGIKCGSYLRCGTGHVDTEHGSVNEVADYTAGMNFVIRTAAHVVFNDKEAEKTTIDFFYDNDSDRSHVIRAKGVRVLRVNTVRDFCEFLCKVENKHDGAKVMERLSKTETEYYNSSWPSPLNLAICVSHPHGTAQKVSFGTIKSSEEETSDQDTEILKILVHRCSVLKIDVKKVFFFYFSEVIIAAYCLRMLASLRPHRKATLLSHLESKGLILRPTEEEMQLIKREYLQERFRRMAQMEDIFSQRYGSQNISPEYKKALVLEILDEIVCEYASTLSVPDGFLDRYKTTFKEIGSKNVEIMFGKQFQENDSSFVQSLTYSVPTCPGSSGAPVWAIVFCNPGQKLFMVSHSKGGGSLGNRGGFGVSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA24</accession>
    <name>A0ABM0KA24_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polycomb protein EED</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112534.2">
        <property type="nucleotide sequence ID" value="XM_005112477.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845596"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005112534.2"/>
        </source>
    </evidence>
    <sequence length="414" mass="46721" checksum="0949BDBF2E77437D" modified="2025-10-08" version="1">MLADVSGDEMDDVSSTASTKEEESSRSDTPTLTGRGRAAMKLKRQLKKCRLQFKCTNYLKEDHGQPLFGIQINQSMKETEPVLFATVGHNRVTVYECHDGGKVKLLQSYADPCTEENFYCCAWSFDDTTGQPILAVGGVRGIIRIISPTMGQCIKQFVGHGNAVNELKFKPKDNNILLSVSKDHDLRLWNVKTGVCAVILGGVEGHRDEALSADFNLSGTKIVSCGMDHSLKIWNLEKEEIKKALAESHVNNAAKTDCPFPTESCNFPDFSTRDIHRNYVDCVRWLGNLVLSKSCENCIVCWRPGGHHESTKLKAEEKEKESVWVLHRFEYRECEIWYMRFSLDYNQQIMALGNQVGHIFVWDLDVDDPTQTKFAKLAHHKSTAAVRQTALSKDGNILLAVSDDGSIWRWDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBF1</accession>
    <name>A0ABM0KBF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rac GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113537.2">
        <property type="nucleotide sequence ID" value="XM_005113480.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849431"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113537.2"/>
        </source>
    </evidence>
    <sequence length="149" mass="17300" checksum="DEDECA7DF1ED6A3A" modified="2025-10-08" version="1">MTLGKNKGESAKSLVAPYDELMRKAKVLQSGCEAEFKIFTVNQDENRVKWLNSEQKNESMEDKLKRLEAQAATLETQLKHARLQAEYELQRRKTAEKEKDDMDRQIGVIRELLVDKNSKSIIHENDRERLAAFTSNQRLSTQNDMSNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV72</accession>
    <name>A0ABM0ZV72_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935146.1">
        <property type="nucleotide sequence ID" value="XM_013079692.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849188"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012935146.1"/>
        </source>
    </evidence>
    <sequence length="798" mass="91231" checksum="487313E20E4F8FBF" modified="2025-10-08" version="1">MPSTPQLSPQEEQEKLLEEALGVVKTQAFQMKRCLDKGRLMDGLKHASTMLGELRTSLLSPKSYYECYMAISDELRHLEMYLVDEFQKGRKVADLYELVQYAGNIVPRLYLLITVGTVYIKSNELSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTKNVLPDSHEDQSVEGMGESGTVMDSVDFIQLNFAEMNKLWVRMQHQGHSRDKERRENERRELRILVGTNLVRLSQLECIDVERFKQNVLPGVLEQVVNCKDAIAQEYLMECIIQVFPDEFHLQSLNSFLRACAELHPNVNVKNIIIALIDRLASFAQSEEGSGIPPEIQLFDIFSQQISQVIQNRPDMPPEDIVSLQVALINLALKCYPDKVDYVDKVLETTEDIFNRLNLDHVEHGSPVSKELMRLMKIPVDTYNNILTVLQLQHYGPLFEYFDYKGRQLMSCHIINNALESETPIPAQENVESILNIVNCLVQDQNDQPDEPEDPEDFAEEQGLMGRFIHLLFSDDPNQQFLILNTARKHFGAGGDKRIKYTLPPIVFAAFRLAFRYKQLEQEDEHWEKKCQKIFQFCHQTIGALIKAEQAEIPLRLFLQGALVAGQIGFENSETVAYEFLTQAFSIYEEEISDSKAQLSAITLVIGTLEQMSCFGEENQEPLLTQCALAASKLLKKPDQCRGVSVSAHLFWSGKSQAKGGELNDAKRVSDCLKKGVKIANQCMDSSAQVQLFVEVLNHYIYFYEKGCEQISVQVLNQLISKIRELLPNLESNEETEQINKHFKNTLEHLQHKLDNQETAGQYEGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV97</accession>
    <name>A0ABM0ZV97_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore coat protein SP60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935185.1">
        <property type="nucleotide sequence ID" value="XM_013079731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855408"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAP" evidence="1">
        <location>
            <begin position="282"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935185.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38055" checksum="3070301D73EEEBA9" modified="2025-10-08" version="1">MQMTMKFKKMCIAGSEEIHVNFSPTACDNLFDVGGSASTKKATMLESKGKVCEVVYPPCGPPIDCSALRKQDPGAKCPEVQCEPIRTCIEQKPVISCATVRCATETTCQMVAPPCVGGELCEPSRPECIPICTKKCRQGFKCESSQPPCPAPVACLDSESLSCTTPTCPYFQRCTDLRPKTCDKLQCSGGKECQMITDTCGRRRLCRKKPKAECVPVCNKKCGRNRECKLTSRCPLDGSKCKHTQKCKRKPGICPKCRPGKECALRQPRCARGRKCKARFVCVRSRGKCPRPPTKKPGKNSYICKRERRRSHQCVNDSHCRTNQKCCTSKCGRKICMRPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVY2</accession>
    <name>A0ABM0ZVY2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Craniofacial development protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935645.1">
        <property type="nucleotide sequence ID" value="XM_013080191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011243"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF67">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012935645.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28449" checksum="4F76C181D7FB4F77" modified="2025-10-08" version="1">MTQNKISILGITDIRKKGTGAKEIHSNFVLIWSGVRKEQRAEHGVGFIVHPDKAKGILNTDFISERLIKISIREGKKTINYIQVYAPCNDSYSDEEKDSFFEQLSDLISNIPDEEDLYVMGDFNGRLGERRTPWTKHLGPHSDHRTPCNYNGNNVLELCAEHDLFITNTFFQHRASQIYTWYRWNLIMVSSQIDFILTRTRMWITITDSRAIPNAGLDTDHRPIITTLTTKKEGKPKKHIKDSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXH9</accession>
    <name>A0ABM0ZXH9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Prostaglandin E2 receptor EP4 subtype</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101847253</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936535.1">
        <property type="nucleotide sequence ID" value="XM_013081081.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847253"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14981">
        <property type="entry name" value="7tmA_Prostanoid_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF16">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01788">
        <property type="entry name" value="PROSTANOIDR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="58"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012936535.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="52099" checksum="397902F1A35F0EAA" modified="2025-10-08" version="1">MLVMDETTLSTLNHVITTDDGNMSQATAAIASVFQMNQALRNQTVLVSSLMFASGVVGNVLALVLMATSPIEQRRTTFYKLMAGLSVTDLFGTCATSPVVISIYATGKLMKEVGALCNYFSFMMIFAGFATMLVVCAMAIERYICVCHPYTYHCKLPKSYARYSLCVSWVFAAFMASLPLMGFGRNAVQFPPTWCYLDLLSKHTEDIVYNYLFGIISLLAILLTFLCNCVAIVSVLSLRRRQRELGASQNGGVRRPRSLVQRCAEMHMVVMLMGVTIVFTSCFGPLMIFTLICQTGLQHRINIPMTYLLIVRIASFNPILDPWVYILVRRELRWKIIGIFRYILGMSRPTSNIYYPNQDCESPIAPTRRPEPEVELSFWKFCLRCLCDPPAQRYSSSLARPSITWATQTNRSPSYIRRLPSSDSLLSGGPGGIMITQPSPSEELLLERLSNSNKKQNGSANGVHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXZ9</accession>
    <name>A0ABM0ZXZ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease K12H4.7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101856256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936810.1">
        <property type="nucleotide sequence ID" value="XM_013081356.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856256"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF5">
        <property type="entry name" value="RE36938P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045509844" evidence="6">
        <location>
            <begin position="21"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012936810.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="52965" checksum="2E11D50E9455A703" modified="2025-10-08" version="1">MKISLSFGLLLLALFASGDAAVPIVSGFLPPPEGTGASPAPDQWFEQPLDHFDGANPRTWKQRYFTSSAHYTKGGPLFVFIGGEGGMSPIWLDEGAWVEYAKTYKAFLVAIEHRYYGKSRPTEDMSTENLQFLSSEQALADLANLLTMLRKQMGGPKVIVFGGSYAGALAAWFRYKYPHIAHGSVASSGPVLAKVDFLEYFEVVDASLRTYDGRGACNDAISKATQEVQAMTETKAGRDKLFLLFKLCDRLNMSIPEDISSFYESLSGPFAGAVQYNSGPPGKTNIDKLCSIMTDSRKGSYVERLAEVVKPDPCLDYKYSKYIKMMRDAEWGPSAGVGMRQWIYQTCTEFGYYQTSESSHQPFGHQFSLPYFIQQCTDIYGSQFIKTLVSRDIVRSNEDYAGLGPKMSRVVFPNGSIDPWHALGVLKDIGPDAKAIFINGTSHCENMGSPSPNDSPQLKQARAEIRSSIGQWLEADTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYJ9</accession>
    <name>A0ABM0ZYJ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101848348</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101848348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012937195.1">
        <property type="nucleotide sequence ID" value="XM_013081741.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848348"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.100">
        <property type="entry name" value="Glycine betaine-binding periplasmic protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF489">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046686000" evidence="9">
        <location>
            <begin position="45"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="871"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1135"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="940"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="972"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012937195.1"/>
        </source>
    </evidence>
    <sequence length="1410" mass="158027" checksum="DD6C6ABCA8E56F1D" modified="2025-10-08" version="1">MSSASGRPDGGVARGLALAHLLWLSLLLPLLLLLLLSTSAPTTAAAASYTAEEDLCPVGVTGERRSQERYFYYEERRLPIVLEDSDRISHRVTNRILKILLQNVAGYKNVEIAYCPSYEKQNITASLDRVSGRMASRHCQPPKVNTGSVAETMVNMEAWMTAGFNKAPWLDTGQLLDAGPLGPQGRLGWFVPMSVVDRFWTNGHRHIVDHWKTFTVPNLARRFSWWGRPELTAVDADFRQRAYRSPKCQENAQGQRKKCATLFAAYRDSGILESQIENLDLWVDIVWLEDHFDKFIKDQLGANEPILFFNWHPNTLIASGQFTRISFPETHRDHKDVPEDCDFPVNQLTKVLWGPIKTGAPEAYHIISHMTFTDLEYDHIIANASETDSYVQQLACHWVQHNRAKWEKWLPLGLTEKPKLHLAGLFPLTGNSWSQPGLVLGAKLAVELVNLDPNTLPNHTLELLVADTECQYDTAISRFISMVLEPEPPIVGILGTGCSDPAERIASLSKHFHMLMVSYGAEAQDLSDRQKYPYFFRTVPPVQHYTYVYPDLFKELGWDVVGALAEGGQEFPGYHLTLQDRLHHHGISLIVRRKFLNTTGTPGVREILQEFKMQNVRVIIADVFSNVAREIMCEAYKLQMTAHDGYVWFLPSWYPEDWVDVEYYNSEPNHQEAYAQRENVPCTSAQVEYAAQGHFVLSKAFTAPADTEVAGGISVNDYRTLYARRCGEQNVEESKFASFVYDAVWVYANGLHNLLERHPGALESLHTKSTADIFRAEISSLSFSGVSGWIKFHGSDRNSDLVILQVFSNETRQIGQFVPSSDPDNKAGLLHMDTSLIKWLSPRGNSQNGVEQGGEECPIESFRAQLGVSCIMASIMVIGMAFVGFIVIVIVFLILIKHRCDVKMRKLRAAHERIKELGLLNEEYSHILTVDDWEIPLKNVVVNRELGEGAFGTVMGGEMYKEGEGWVAVAVKTLKLHRTMQEKLDFFSEVDMMKGLSHQNIVQLWGVCTRKEPMYAVMEFLLHGDLKTYLLSRRSLVGQGVKEAEDVKAANLTQMAVDVALGLGYLHSLKFVHRDLACRNCLVHANKTVKIGDFGMTRHVSSTDYYRFSRRGMLPVRWTAPEALKDGIYSAKSDIWSFGVLVFEIVTFGSFPYQGLSNKEVLDYVSSGNQLILPDKCPADLKSFIHWCMSTDPGYRPDLDDIVSYLKFSPSFLTPCLDAPTTSVVHEDTDSLEMPLPDKSLGHSYAGGVEQDPAPSKHEKLGKKKTFSVLGLPSLSKSAKSSVNRRSPRSSRSSSVCTDTLHSASVCGLYSSMIGGNNLDEASGSADNVFRSRSCDFVNESELKEFDSDRGSRGDGSAIVCDGEQSISQQHSFGSDHKYLSSILSREREEESSGYLSQESKQICQTVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0P6</accession>
    <name>A0ABM1A0P6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101849697</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101849697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012938448.1">
        <property type="nucleotide sequence ID" value="XM_013082994.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849697"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012938448.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="24840" checksum="9935C800AC03FE62" modified="2025-10-08" version="1">MGEGSPSSLFKLIVVLTLASAGVYTVGMASPYWLSAEFRIPMPPPANLKVESHMGLFTNCKTIHYPKSANEDCGGDGARDWQYIAAGFAICGLFLGVVAFVDGVLVMCVRKFMGNKKIQIVQTVLNFLTAGCMTVSLILYSLNRRFVVDPRLPTFYVDFDFKWAFIVSAVAAFLFIGLFALNIIDLLLSSSSGVDVSNDDKESQEVNYTKTLNGGNVTVLGQRQRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0T5</accession>
    <name>A0ABM1A0T5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WASH complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101860655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WASH1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938504.1">
        <property type="nucleotide sequence ID" value="XM_013083050.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860655"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028290">
        <property type="entry name" value="WASH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021854">
        <property type="entry name" value="WASH1_WAHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331">
        <property type="entry name" value="CXYORF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331:SF1">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11945">
        <property type="entry name" value="WASH_WAHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH1 WAHD" evidence="4">
        <location>
            <begin position="6"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012938504.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="48427" checksum="A122D97C3A691F26" modified="2025-10-08" version="1">MVVMGIQGFNVPTIPPDLRREETIHHIADALEYLDKVANEVFARIGKRVTENKAHLQKINDRVNVAAARVDKLKGSNKATKVFACAKYPAEDRLQPFSAVFTDTDGLREIKHHHFKVQEKHPAVDEQVLREKLQFYNVHLSIRARKDQSQQGEGLGGLPSDVPSVSSLLLFNTTENPYKKYVMLDPLGVVTKTRAAIEEEEAGMAEAPSTIIHNEEMFRAAAENFLYMPELGTVPEIAVPELLPNLPGVADDLAFSADQGPSIAPSVMGSNMPDLPAVGPEPDAVPAGPTSAGGPADASGPPPPPPSGPPPPPPPPGPPPPPPANVPTEVATPGGGRQSLLDSIVQAGGAAGAGLKSAKDRKHTQKKKKQEEKDQGQAAPSGGGGGGGDLMSDLFSKLTMRRRGISGTPKGGEKSDAGGGGGSGAGSGGGGSAMDKISSMIPAPPKNNAPPPPADDDDDGDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2P8</accession>
    <name>A0ABM1A2P8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012153</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939639.1">
        <property type="nucleotide sequence ID" value="XM_013084185.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012153"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="381"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939639.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="63121" checksum="6AA78F61A42D351A" modified="2025-10-08" version="1">MRRYGLHILGISESHWTGSGRLRTATGETLIYSGREDNQHRERVVIILKRGLEKCLMEWKPINSRMMTLRLKGKHTNTSIIQCYVPTNDSEDESKDYFYEQLQRELTGIPRHDLIVVMGDLNAKVGEDNTNFERMMGQHDTELKNRFQALQDLEETTPNTDEVNTQWKHIVEAFTESSKTCLGVKEKNANKEWIQQGTWNTIEERREIKKRQLAAKSIRLQEKYAEDYKEACQKVKRLFRKDKIEAMEKLATEAEEAAAKGEQGNVYKITRIICGKYHSGMSGPIKDKAGKLLTIEKEQEARWTEHFREVLNQPPPEDTPDIQEATLDLDISSDPPQKHEIVKAVKSMKTRKSPGMDNLNAELFKVDPELTATILQPLFKTIWEGEQILEDRSTGVIVKVPKKGALRDCNNWRGITLLSVSSKILAKIIINRMSDAVDSCLRKEQAGFRKERRCTDQIFALRDIIEQCMEWQRQLYVNFVDFEKAFDSVHRESLWYILRSYGIPCKIVEVIKSFCQNFKCVVGNSTTAFEVKTGVRQGCNMSAILFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3X7</accession>
    <name>A0ABM1A3X7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012303</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940326.1">
        <property type="nucleotide sequence ID" value="XM_013084872.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012303"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940326.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="67689" checksum="796F3FDF459F31B7" modified="2025-10-08" version="1">MTHSDEELMSLMESPTVSAIMEEVAPSMSGHHTTHRENTSIFSSVSAQVDGAASWRQRTPGGAVAADSCDTRDRACNYGFSRCQTSSPQCLTTPSKPSSSCWAHPGGNLAEIDDDCRPDTAEFRMNEMVAFPTMSAVNLNSLSGKVDPDDAKTHSSDSASCCMSTSGKSRRSAIAQSVQRAPVISHTSDDCRNWTEFSPHSNVIVATKPVEDNSNFHETAPHSTHCLLPMSPKPWTDGPNWKETIAPSGPKPWTDGPNWKETIAPSGPKPWKDGPNWKETIAPSGPKPWKDGPNWKETIGPSVPKPPTDWSHWGTSKAGSVSSTPLTYSSCWSKPITAQTKNIMPTSLKSVDEDWTDKNEETVVQIQNTAVTPKSVHHQDNAFNQDESAPNVEEESISWSPKDAILSSPSTDDGFSQSSHRYGKVLAWAKSSQGANGHLSSSLHKSSCSSQQACLSLSSGEVAGGPSSLLQVLEEQQPQACLSVSPDETPGTSSLPQTPSKTNVMTTTQEQTADCSSSFVPPAANTMTLLLSGSTQRRDLRTFPDTHTTTTTTSPGLFPPTEVPALSRRCLWRQEGQEEERELCVSTSTPALKSASTSRNFLSQLFAAGDSSRNSSHQLMGNVFDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4T0</accession>
    <name>A0ABM1A4T0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box/LRR-repeat protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940838.1">
        <property type="nucleotide sequence ID" value="XM_013085384.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852492"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="570"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012940838.1"/>
        </source>
    </evidence>
    <sequence length="609" mass="68997" checksum="063657D9C0079539" modified="2025-10-08" version="1">MLRDVFSQFGRVLFAKIVFDHATKQPKGFGFVEFEKSVAARKALSANPESLQVFDRMLRVRPVVHNRQRGKSNSESSSGKDSNTAQKANPCDLDGHDERLPMTCGTQGAPFDILSDDELVLILTYLGFIDRIRVERVCSRWQTCALRAAKTERHLTLYKEFRTFGAFSENIFHKIMSRCSQNLKSLDISQVSSRFGNRSLSIIGQCCSNIEQLDMSGVAADNHGLEELANGCKNLKSLTINRCYPVGEKGVANLFRKCQKLEKFVCMENQIINGKFLKYAQPSMKTLCLGDCHKLTDEGVMNIVQRCPNLQDLELDHCSRLSLETLNAVVKSLHHLRVFSMGANPPDISKDPAPHTVHHLVNPNLLISLNVQNTGLEDRDFSLVCRRCVNIVDLDISCNKLTDKSVTQISNLKHLEVLNACHLQNITDESLLDTVNRGNLRKLLLQGSKTISDRIMLEAAMKCPQLEEIDVAGNPFVTYESLECFHKAAEMRKGRKILCYFTMKTIPSSSSMDNRKGIRFIDYYRPKYSAKISWRCWSDQEAFDLSEHNMELLEARSYWPMSFNKVDATAYRDPDSDTDSSDFESTGGEDDDEFLLNDDPLEAERFEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A557</accession>
    <name>A0ABM1A557_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin deacetylase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941026.1">
        <property type="nucleotide sequence ID" value="XM_013085572.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845116"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF3">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="107"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941026.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44212" checksum="671C8B19E540F54F" modified="2025-10-08" version="1">MKSLVYVHKRGNAPCLLTALLLVAAGAFLTLFSLGFNTARHSEHTQRRTQTDDLTSYYASHKAYSGGDEVRKNLVAECTEETCRPPACVCARTSHPGSFPLREVPMMVMLSFDDHVNNLNFHHVQSLLDRRWKNPNKCPATFTFFSCDVATNYSYVRKLHTLGHEIGSHSVTHRFPIQWWTNASIQELTTEFSGQRDKLVQEAGVPHEAVKGIRVPFLMASKDRVAKMIQRSGFKYDSSLAAGSELVRGDPPWWPFTLDYPPRHLRIQGRYPGVWEVPLNLYDCFNGKGGYFMLDQCPMRNNTHEILGYLWRHFAYHYRSRAPMGLFMHVNWFNLNSASHEALTTFLDQLSIMPEVWLLSVSQVIQWIEQPTPISELKRFKPWGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5L6</accession>
    <name>A0ABM1A5L6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101861377</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101861377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941278.1">
        <property type="nucleotide sequence ID" value="XM_013085824.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861377"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06350">
        <property type="entry name" value="PBP1_GPCR_family_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047160975" evidence="9">
        <location>
            <begin position="26"/>
            <end position="2895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2595"/>
            <end position="2618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2630"/>
            <end position="2651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2663"/>
            <end position="2684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2705"/>
            <end position="2727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2756"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2789"/>
            <end position="2812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2818"/>
            <end position="2836"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="2598"/>
            <end position="2842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2876"/>
            <end position="2895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2876"/>
            <end position="2886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012941278.1"/>
        </source>
    </evidence>
    <sequence length="2895" mass="320163" checksum="D4427B75F0CF4230" modified="2025-10-08" version="1">MAFFGANIKVVALLSLALLPVISLGQTLSTQTCSTDGSAVVQQGATAWIIGIISLNEEGSSGYGCGSPGDGSMHSYEAMRLVLELLNKKNGTLGTTRLTDSYVPGIKLGMKVKNYCSNEKSAVAAVSEYFPQLSGDGESCTRDVDNLTLGIIGGSTSDVAMALSEEAAPFHIPVISYEATAPQLTVPGKYTNFMRTISPDGPLIEVIVQLMKKMNWEFVAIVYDSGTYGRSAYSELHARLKDADICLTAGIMIDDSDETTASDTLSQVLNTGTTGVVFFGSPAYARALVERGDNRLPDSGRLQWLFADLNLEMTFPASSVYQHGIIAVTAASRFIVEFEDHWMRINERRVNSLQALENPWFRPWFEERNACSFNPLTTGLRDCATIYGTMTADEIEDMKRRAFQQDQYAEAAVMAVYTYAYALREAQMDKCPGVSGFCPALVAMERQEFFNDYLKKVNLRFKTTERIPTLGTYDVAPYYSPKRLRFNANGDLAEASYFIWNYNDIESGNRQSDFKFRRAGSYVDGTLILNNVAMYSEDRKTRLSSLPPSPCPSAGCGTCLGLPADLKYYYTPGDVVISGTFSLHKMGSTPISCGGRISVNQYQYMEAMIYAVNQINNDPSILPNLKLGGLGFDDCSSSALSQSFLAQVQRGNIVIKSSGGEELDPRTVEAYTAAYSSPLTLPLAEAMNMLMRPMVGYRAGSSELDDDRRYPYYIRALPGIYEEIKAMILLLKQWNWMYVQLVTSDMHYSQNAEKVFRELSAKEGICVVASHNIGTDVDGAERMLMGLQANKAVSPTISLLDSHDNQRFLAILANNTAIRRDLAILATTSWGTSEMIVDGFEDVANRVISLSLRHSTLGNFRNYLSGLQVQTYTSNPWFSEWYMAVHSCTLGVPSDGVPICDMSQPITAGGSKFRLMYEVESVINAVKAIADGLDKTLRSYCGTGYKNVCNDFINAADKGKVFLDTIKAVSFPIENMLAPNTFQFSGKSAVVPFEVYSYKAGRYVKVRDVDPWAQSIVGSAVIQLYNGDAPLQASSSCPAPCLECLYMFNYMKYWYVPGDVVIGAIFDVHYAGSGPFMCGAVRKWNGALYTEVFNFALSRINSGAASVKLDNFKLGGLAVDGCSNPIRSTAIVNRVLMGMDIRSAASGEMFDSNSLVSWMTYDSQTTIDTARLLQALNMPVVSPGATALALNDKKEFYTFFRTIPSDSLVVKGMADFINAMGWKYVLVLNSPDETNREAKDLFKKHLEGFGICVVASYEFQTDGSNEVIIRGIDEADTQIVAVFSEPDRYIESFITEKSNTLTSTPLTYIANRRWGRFTEQFINTATDVSLVNSVFFDLDSPTIAEFTNYLNGRDALTTDNNPWFQEIYEEVMGCNLPGSFIPGRGNCDTTNSRRFNPITSGRNWEQDIWTLSTMNAVYAIAKATNNVKVSVCGPGVALCPGFFTQDDVHSKIMDELDRENFTDIAGMAFKFFEREADRGYKMYRYRPNIAPQEEGVLTRTTALSLSNSLALKELYASLRSQCPGDCLTCKTSATDLQDFTLISGDIYIVGLFDIHNEGYSPYTCGEINGKHGLQLLEAFNFAIEYVNNHTGMFSDILQGVRIGGVGLDMCKSPTRAANLVANIHSGDVTLSKDGETVYPRRIDAYVATMDTESSIRVADVLTQLAVPQISYGATGMDLLNRNKYKYFLRSVPADDKLARAIVSYLKKFSYTNIQVVYSFDEIGEPGLEEFEKVAFVNKICVGRKHLVGESGMVSEQEARAVVNRISNTRNPEDEVVVLWMKNPLPILEAVNNNDEVARHFLFVVTDKWGADPDFLKMSSLQTLLRFKNLVTFDVETADIPAFDMYLEHKTPDNYRSNPWFQEYFEHLQGCSWGAAAGGAVKPCDPSSTIPRADEYVQDPYVLYVINAVFSVALGLDDALKAKCKVPGVCDQYRNSGERRQRLMTGIEKVMYTDDTHQPFFYTEDGQSDRGYHIYNVTSASATTGTEFSYMNVGSYNDSHFLKLDITYDSQFSAYCDSNLETPDPSDDCSCPFKPVVPSRYMKKDEGGRGLTLVYVGDIHQRDPNHALGCGPINTGVDLQRLLAFFFAIDRINNNADFTLLDSIKLNGLALDSCTHGLRLGQDVYNVLSGNQLCDTDEGGQLVAPSSIIGFVVDKDKNTLPISSMLAQQKITTISPTATLSVLNNRYQYPYFLRVRNDNDKLAEVILSIGRRVGWDYMSAIYTDNIQHRSAAASLLAASKDRGVCMADAAGLAEDATLEDAKQVLEKVAKQVGARGVVLFVDPPHLTLLLQASREAGLSGAFTWVVPSDWAHSGENIAGLEDEVSGSITIETRTAILEEFTDYVRSLTYNNRQGIPDDWFMNIYQAIHQCSLIDVEIPHIRRYPGVCTKGEVITRDMIAQDPSVLHVIISVFSAALGLNNIPQCLRSSLDIAACLQLQERRNELIYDGISGVNFQVLPDLLGQDSFQFSFDSNSNGQMGYIIKNYRAVLDSEKSRYNGSSYAAFPIGGYSSNGLSLDLSLYGGGRSLESGAVPASICALGSTCTCQLPGGQQWDYSPAPILDPSNVQVGGTYRDPETGEAVTVTGIPQTSDRFNKAWGIILAILAAIGAVISFGLFVFLLIMYPIRGGTSILGFILAFGIVLLYLMVFPFIAHADERICGLRRFSLGVVYALVYSALLVKLVDCWRVRGKGESYNVKYSKLGRPAGLFMVTIFLVLVQVMINAEWLILRPPDVVRVFYEEQFWPRCSTHDFYDESLVLSLVYVMVLIVLSLVLSLLTFTSTTNHRESRWILGITVISIPCWVIWCSVATLGAYSVRDPAVAVGLLVNATVMLLLVPVRKLYLLHKYNALIEEEEERESQYAASHKDNDYNSVYGRQYDNHPRLHDTSSNHGSSRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5P0</accession>
    <name>A0ABM1A5P0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase 34-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941314.1">
        <property type="nucleotide sequence ID" value="XM_013085860.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012553"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012941314.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14305" checksum="D2BEA6E73479BD4F" modified="2025-10-08" version="1">MACEYSTAFMRQLAGHQNLQWAFKNVLPYPHQYLEATEELMCMMKMMADRKPEHCAEEAAAVENFRKTILTVCTTGLDPRVMWQTLCSIYKVLVETPEDHLSLLYQNGLSVLSQVSLCFNGLSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5X0</accession>
    <name>A0ABM1A5X0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Gastric triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10" type="primary">LOC101849146</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941443.1">
        <property type="nucleotide sequence ID" value="XM_013085989.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941444.1">
        <property type="nucleotide sequence ID" value="XM_013085990.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941445.1">
        <property type="nucleotide sequence ID" value="XM_013085991.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941447.1">
        <property type="nucleotide sequence ID" value="XM_013085993.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941448.1">
        <property type="nucleotide sequence ID" value="XM_013085994.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849146"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021901" evidence="3">
        <location>
            <begin position="29"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="149"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012941443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012941444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012941445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012941447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012941448.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53231" checksum="186C34F19A3194A5" modified="2025-10-08" version="1">MARFSCKPWSLLINFMIFLCCLTVNVSADDLGHFLRSESGDKITFSSEKVLSLLKRFGKSEGDYSLFRQHESWQENVRDSSRLGGHVFRKNKLDPDARKNMTELILSQGYISEKYTVQTEDGFLLDVHRIPSGRGEIPISSDGSGRSKPVVFLQHGLLSSSCDWVMNFANGSLGFILADAGYDVWMGNSRGNTLSRKHVKLRPGNPKFWDWSFDEMAKYDLTAFIDFVLNKTNQSSLSYVGHSQGTTMAFALFSQRPDMQKKVNIFVTLAPVTLISNTVSLVQYLAEIPDEILFAMLGRRDFLPSDLLVRTLVDLLCHDEATRWVCYNILFILAGPDLTNLNQTRLEVYMNHSPAGASVKDIVHFAQIYREKKFLMYDFGSPSENMKHYNQTSPPEYVVTNITVPVLAFTGTDDWLSDPEDASALLNSLPDVISWVVLDGWNHLDFVWGENAAQLCYHPIVQWLHKFSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A614</accession>
    <name>A0ABM1A614_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864083</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941521.1">
        <property type="nucleotide sequence ID" value="XM_013086067.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864083"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941521.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20367" checksum="2A508637CE7B5EF6" modified="2025-10-08" version="1">MTLLHKRLCWRSSIAALVLGLCVYVTSYSTDAWVLWSNQISDFQDGLFRTCSRLKEPGTGWHCHTIQNSTDYWSISIGLLSCGLLLLLLGLSLSLLAAHKSKRVFSCWAGVLLVLAVIIGTAGGANFVGRSSEDLASTRIGWSAILFFVSPALLTTGAILQLLSSKPSSVNDESSVLLYSASVRLDTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6G3</accession>
    <name>A0ABM1A6G3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101847059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941731.1">
        <property type="nucleotide sequence ID" value="XM_013086277.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847059"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012941731.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="16981" checksum="806851EC1AF46926" modified="2025-10-08" version="1">MSCDGGVKTRTRECTKQPCDEPTSQEAACNEQDCPIDGGVGEWGDWSACSRSCGGGERIRYRFCDNPAPDHGGRDCDVELTETEECGQQPCPIDGGVEDWSEWSECSVSCGGGSQTRIRACNSPSPAHGGRTCSDPLNEDQDCNTQECEDDVCETEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6H0</accession>
    <name>A0ABM1A6H0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101860836</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941742.1">
        <property type="nucleotide sequence ID" value="XM_013086288.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860836"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045310186" evidence="3">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012941742.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45653" checksum="00F2F313B6DE9961" modified="2025-10-08" version="1">MLNMWMLSIASILGTAVAVSTVVRQMTWIEGSTTTFTCSGDNVNFDKIPDSEILSVQLVKYKGPGRLFRAVASPWTNMSRNYSQPWKFSVGQDGFIIKVTIYPVRCTDQGQYFCIVEYRQKLTFLNGTEIYRYRRQLDEMRTVIVRGSNAVALYNDVQLKTQRLTKAWRQWGGYLVQPEDRIRISCQVKGPETQNHTWEWTRLCIMHTSKGEEKILHYVKEPWKVHELVSNIVLAQSFKGNCAHYTFLSWIDASLPQRALKCWTRCKFLCDRPGCNDLEQRVALGSTENEPTVKVDKLYAIGVASGITLAIVACFLVVVVPIWVGCEFILQPCSPVFALFEEKREGDDTNAGWRLQRLVDIPEAEETVEEDEASTDVPSDLDGDVDVDVDGDADGDVDGDAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7Z6</accession>
    <name>A0ABM1A7Z6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Ferric-chelate reductase 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC101860119</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the insect defense protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942585.1">
        <property type="nucleotide sequence ID" value="XM_013087131.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860119"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF9">
        <property type="entry name" value="CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046961254" evidence="17">
        <location>
            <begin position="24"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="19">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="18">
        <location>
            <begin position="352"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_012942585.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="69203" checksum="78373AF5A39256E7" modified="2025-10-08" version="1">MEYTDRTLRILACVVQLLALAQGFSFGAPTGTCWTMYPKHSNIPRQSSPSPFTVTLSPQKYSPGELITVTIAAPDRRNFTGFQIGAHRQTENTEEIVGQFTDYPGDKVTVFTCFGGFKNMATHWNSKPTDSIALGWQAPPDNVGNVSFLATVVADYSTFWIDVTAELSPQDESLAVAAPFYPAIPLQTNITDIDLSSCGESKGCFLYPRHCSDTDCLAAVTYEYREDTKDVRMELYTDAADIFNYISVALSEDTLMGHYDETFTCVSNHGEMSVQQGYNPEYHNGRMFTRFISDTKIKHSDGRLHCSFTVPLLTEIYSVNQETPQFQYKTTPISLERAWYLQLAWGDAMPGSDVIAYHKEMPPVTDDPVDVRKVKVERGSAYHILVHVHVVVMVIAWVFLTGLLSVVSRHYKQWYPKKTWCGTKIWFQIHREMALLVVALTAVGLFCVFYHYGSEIRKFAVPHAYVGLAVTAGVGVQVLMGFLRPGGDHKLRPLYNWGHFALGHLTHITAAVTMFLAYDIEHINRDMRRFGYVTLSVWLVVQVLWYLVFEILSWRQKKAKSSDSYAIETVSKDLQIAEKDGNVHGDCRHSLLFTIYVVCLAAVCIAVSLSFNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8B3</accession>
    <name>A0ABM1A8B3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101847681 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847681 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101847681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942756.1">
        <property type="nucleotide sequence ID" value="XM_013087302.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012942757.1">
        <property type="nucleotide sequence ID" value="XM_013087303.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847681"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021910" evidence="1">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942757.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="24333" checksum="AFAC04CF80C6D977" modified="2025-10-08" version="1">MSPVSLLLLSLAFTGCSAFGGMGRFRNPMFGGMGKFGGQGQGFPGRFPGQGQGFPTGPATGRSTPSVCSGKGTLGQRFAVNIGINDADNDSFVSGPEMYNDFRNNYDTNKDGCVTLAEWEQRWVQGLLFSKAFADNRWAALQPSNNTACPVTYASFQNNTNMRMPLGGFISGNLQTLVDTCKSDNSLLISNCDCLQLLGACVNDATLSANSVCNTYVAQPVNATTTPVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8C8</accession>
    <name>A0ABM1A8C8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Epidermal retinol dehydrogenase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8 9 10 11 12 13 14 15" type="primary">LOC101853580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942779.1">
        <property type="nucleotide sequence ID" value="XM_013087325.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827969.1">
        <property type="nucleotide sequence ID" value="XM_035972076.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827970.1">
        <property type="nucleotide sequence ID" value="XM_035972077.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827971.1">
        <property type="nucleotide sequence ID" value="XM_035972078.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827972.1">
        <property type="nucleotide sequence ID" value="XM_035972079.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827973.1">
        <property type="nucleotide sequence ID" value="XM_035972080.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827974.1">
        <property type="nucleotide sequence ID" value="XM_035972081.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827975.1">
        <property type="nucleotide sequence ID" value="XM_035972082.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827976.1">
        <property type="nucleotide sequence ID" value="XM_035972083.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827977.1">
        <property type="nucleotide sequence ID" value="XM_035972084.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827978.1">
        <property type="nucleotide sequence ID" value="XM_035972085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853580"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035827969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035827972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035827973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035827974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035827975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035827976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035827977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035827978.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="34916" checksum="2EDACE073CC00333" modified="2025-10-08" version="1">MDMQIIFDGITAVRNIFAAFFLSWIRFFFSGYKKKSVTEEIVLITGAGSGMGQGMAMEFAKLGAVVVLWDVNNKGLEETVKMVKAVEGVCHTYICDVSDRAAVRETADKVRSEVGDVTMLVNSAGVVAGRRLLDLTDQQIEHTFGVNLMGPIWTTKEFLPSMLENNQGHIVNMASSCGLIGLSHLTDYSASKFGVVGFTQTLNYEIHFSGHDGVHTTLVCPSFVTTGMFQGCRMAFPLLIPELEQNATVQRIMHAILTNQSEVYIPRLVYFMNSLKTIIPVSAMLEVIRFFRADKFMHSFVGRGKDELSLPAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8Z8</accession>
    <name>A0ABM1A8Z8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101850750</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943111.1">
        <property type="nucleotide sequence ID" value="XM_013087657.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850750"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943111.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28208" checksum="CEC44570B7355967" modified="2025-10-08" version="1">MVQNSSVYPVHENMTSLDLAFVMISNVTSFLSVSGSLAIISCYVTMKEIRTTSRLLLVFLSVANIIQGLATLLQTGTYYRSVQFPPESSFLCQSAAGLMVLGHVCCALWTVAVTFYLFLCVAGHCITVANRILFLLHAFCWIMPRRSLSSLLAMGDNLQGLVNAVFFCLATRQIRRLMYNKLTRCCTWARANRIIGHDHWVRVPSIVRAVTHRRPRKHKDMDGSDLDISGISLDLPSPDGDLGTGEDDVIFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9E6</accession>
    <name>A0ABM1A9E6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013098</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943347.1">
        <property type="nucleotide sequence ID" value="XM_013087893.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013098"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045706315" evidence="1">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943347.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24890" checksum="4BF2EA8D89954424" modified="2025-10-08" version="1">MALLRCVLLTLALCIVDAARVCERLYKCSRPLEQYEFTAMGSDALINLSQERVLDDFCGQVPTLEQCVHRLTASCAHPSVRNEVDSTVEVSKYMCSLKGRSQLLSLGDSACALDNTLLTAMSARIQDCFLTFTTHLQRLMQHAAHRGTHPSPAQTCPHTVMLRECLSQQTEDTCGPEFKTFLLDVFNLSASRIFEPLGCTQQARHSKRLVTRALNLQEQLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAM3</accession>
    <name>A0ABM1AAM3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106013295</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106013295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944052.1">
        <property type="nucleotide sequence ID" value="XM_013088598.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013295"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012944052.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13576" checksum="D9CD6A9F6A1402CA" modified="2025-10-08" version="1">MESQGEFEVACSVLTRTRVKYTDGPAVPCPIFSEMKELTVSHFSNWLQEQSLLQEGRHQNHEEEEDMVLLLRFEDGQPEIMEERRTLEYYLDALNRASHIEIAPRHMMPVEVEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB63</accession>
    <name>A0ABM1AB63_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101863140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_012944355.1">
        <property type="nucleotide sequence ID" value="XM_013088901.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863140"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF27">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046457051" description="Angiotensin-converting enzyme" evidence="7">
        <location>
            <begin position="22"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="932"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012944355.1"/>
        </source>
    </evidence>
    <sequence length="1250" mass="144134" checksum="302D48446CDEC083" modified="2025-10-08" version="1">MDGLRFLVLSALVLSASVCHGASLNTNETEAQQFLDDYNAAAIDDYYISSEASWALDTNITEYNTQKMIEAEAKSANFSRKMAQEAAKFDVSKMSEDIQRQFRFLKDVGTAAQTNITKSARLTNVSAQLESIYAKAKVCLSSDNCVSLEPDLTRIMAKSRNYTELTTVWKKWRDVSGKVMPQLYSEYVDLNNDAVKLLGYEDAGVYWKYAYDTPTFENDTKRLYEEIRPLYQLLHAFAKKRLKEVFGAERFPSAGHIPAHLLGNMWAQEWNERIDILKPFKDKDSMDVTEELKRQNYSVDKMFRTSESFYKSLGLIGMPASFWNKSMLVRPDDGRDVVCHASAWDFYKDSDVRIKMCTDVTHEDLMTIHHEMGHIQYYLQYQNQSVLFRTGANPGFHEAVGDVMALSVGTPEHLRTIGLYKNQDNDEETDLNFLLNMALQKVAFLPFGYLIDQWRWSVFRGDTTPESYNEDWWSLRCKYQGVSPPVRRQDTDFDPGAKYHVASGTPYIRYFVSHILQFQFHKAACDAAGYKGPLHHCDTYNNKDAGTLFHNMLSMGASKPWQEAMEVMTGQRNMSAEPLMEYFKPLIDYLKKETTGENLEWTDDCPQEDYHEQMDQLDDVEDFLSNYNEGALTVYNQAMEAEWAKKTNGTEENEKEMVRRQVRKAKFRQRSYKQAAKFDDVKVTPDMRRQLNKIKDIGASALRNETKLERLQSIISDMGSIYSAAKPCLSNGECMLIEPGLTRTMTESHDYDLLLSAWKGWRDETGAKMVDLYREYVALKNEGVRELNFPNYGAYWRSWYDTDDPDYRFEDDVFQLLRQVQPLYEQLHAYVRRHLRTKFGDDKMPTTGHIPAHLLGNMWGQTWDTLYGELAPFKNKKPVDVTAEMIKKNYTVHTIFESAEGFFKSIGMLPMTDIFWNKSMTERPKDGRIVDCHGSAEDFYKKDDFRIKMCTEITQESFNTVHHEMGHIEYFMLYADKPLVYRDSANPGFHEAVGDLISLSAQTPEHLVKVGLLDPNYKADNETDLNFQMNMALQKIAFLPFGYLIDQWRWGVFSGEIPPEKYNEEWWNLRCRLQGIAPPVLRKSTDFDPGAKYHIPNDVPYIRYFVSFIIQFQFQKAACEAAGHTGPLHHCDIYQNAEAGRRIRSMLELGSSRPWPDALEQLTGSRRVDASALLEYFQPLHDYLRKENGNDYGWDPICPRSVQRKTSSCSACKKCPPGTAGIKPSITYQEVLILSLVSLIIGSYLCDSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACD0</accession>
    <name>A0ABM1ACD0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106013547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106013547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945012.1">
        <property type="nucleotide sequence ID" value="XM_013089558.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013547"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012945012.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16930" checksum="5806D7F80619FE20" modified="2025-10-08" version="1">MFGLGTDGSREHKSSRKLNRLLQIKKNLVESLTLLSKQSVASPQTRAVGVASPQTRAVGVSSVCAAEKKGVHLHPDGSISAMESFLHSLHHSHWGQGGALRSWDYQQTLPAQQQQHHHHQNYLVFFFPHHKITSTATTAVTTALSVIEDQVKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACS4</accession>
    <name>A0ABM1ACS4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polycomb protein EED</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101862540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945215.1">
        <property type="nucleotide sequence ID" value="XM_013089761.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862540"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="397"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012945215.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48806" checksum="7C77E2D6996906CA" modified="2025-10-08" version="1">MDNVEEATLSLSKRQRLIMLADVSGDEMDDVSSTASTKEEESSRSDTPTLTGRGRAAMKLKRQLKKCRLQFKCTNYLKEDHGQPLFGIQINQSMKETEPVLFATVGHNRVTVYECHDGGKVKLLQSYADPCTEENFYCCAWSFDDTTGQPILAVGGVRGIIRIISPTMGQCIKQFVGHGNAVNELKFKPKDNNILLSVSKDHDLRLWNVKTGVCAVILGGVEGHRDEALSADFNLSGTKIVSCGMDHSLKIWNLEKEEIKKALAESHVNNAAKTDCPFPTESCNFPDFSTRDIHRNYVDCVRWLGNLVLSKSCENCIVCWRPGGHHESTKLKAEEKEKESVWVLHRFEYRECEIWYMRFSLDYNQQIMALGNQVGHIFVWDLDVDDPTQTKFAKLAHHKSTAAVRQTALSKDGNILLAVSDDGSIWRWDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADV1</accession>
    <name>A0ABM1ADV1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain family 4 member D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945801.1">
        <property type="nucleotide sequence ID" value="XM_013090347.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013758"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047044609" evidence="1">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="50"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945801.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19513" checksum="8A374EE37526D8AA" modified="2025-10-08" version="1">MRLFVVIFCLLVASGSATQTLLGTVNATEFTFHQLKDLMYTQFTPLYWNYLLSTFYATSNDARLLCHSVDGEIIRLRNRRQMNVLVQELESLGAYDGQMIHIGGRRRSNAWNFDINPNENLYPFWHDQEPDGASRNENCVILQRRSGNFRQVDVPCSLKARYLCQRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE61</accession>
    <name>A0ABM1AE61_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013819</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945971.1">
        <property type="nucleotide sequence ID" value="XM_013090517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013819"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945971.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20461" checksum="E6F713C4A16178A1" modified="2025-10-08" version="1">MDYLLLKKIIGERNRRTQTENDPETEEDDEKERALGKFLGRLYEEMENTDDGNSDSRRKGTGIKQILEDYVLIWSCGDGTTRATHGVDFILHPDTAKNVLETEFISERIIKIRVRGEQKISNFTQAYAPCNDSCSEEQKEDFFEKMADTMGTVTDREELIVMGNFNGRVGKRRTHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFM5</accession>
    <name>A0ABM1AFM5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat serine/threonine-protein kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106014173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946704.1">
        <property type="nucleotide sequence ID" value="XM_013091250.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014173"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012946704.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="73706" checksum="DB58EB12FC22303E" modified="2025-10-08" version="1">MPDMIYVRSAEPRLALHVAVAHHHVATVESLLHRRYPSSNMLTFVDPDSTLTYEAGLEVNAQDSNGETALHIACRSGYADIARLLLEFSVRVEVDKTSVQRARSVRSKNFELEEGIVEEGEEGEGTEGNSEYASDSDDGTTDSSQSSPRKGHSRKFYRIVYPVSVSAVTSRGFTPLHLAIRNKHVAVVKEILDLRGPPSNIMKVNDRDYSVVLYAFEEGNTEILRLLLSHGMLDIDNKALSAAFFAHNAEAKWLLLTHKSSRDLNHSINKTEMRRLAYRLSHAVSDTLDRCSSLDPELRSKFPTTPVSIGWEGLGVLSAMDARCVSQACVLHNPALTAGVLPAISLCAVTKVDISRNSFEVFPAVLLELPSLVLLRASRNQIGEIPSEVNVLCVSLEEVHLNENKIRTLPRFLFQLPQLKFLDVSVNRVSEVPPEVWSAPSLVTLHLSGNSLSWLPTTSRDQLSWPPPQGSGGGAARPRRVSMGSLQRDHSGSVGSYDLDPLDVSVDGVEFTILSHQDVSSNSIVRVNKWGAGVTVEDRDPWKRSGQGCGLKQLWLNRNRFTQVPPCLACCAPTLEVLVLSDNPLTSACAVSDYPPSLVELDLSRTGLTSLDVWRSPGDAPHDMACFGPLSFSQTSRYSCVPLSTNNSPGNNYPRSNSTSNNLHHHHRSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VNT0</accession>
    <name>A0ABM1VNT0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824072.1">
        <property type="nucleotide sequence ID" value="XM_035968179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864287"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF58">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="21"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824072.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="55281" checksum="7DBF37CD10112060" modified="2025-10-08" version="1">MADNSTQSAQVMDITWDDATWILTSAFIIFTMQSGFGLLEAGNVSPKNEVNIMMKNVVDVVFGGLTYWMFGFGLSFGVDKGTNPFCGVGYFFVDIEDENMGVIYSTFVFQLSFATTATTIVSGAMAERTKLTAYTLFSFFNTVVYCFPAHWAWASSGFLSQLGSVDFAGSGVVHLVGGVSGLVATIMLKPRQGRFDDKAQPEMANPANAVVGMFMLWWGWLAFNCGSTFGISRGKWKLAAKTAVTTLLSSMSGGIAGTALSFIVHKGKYDIGYLVNSILGALVSITASCPLIHPWEAVLIGAIGGVLVIGVDHLLVKLKVDDPVSAVAVHGAGGLWGLISVGLFTTQDPVENITYGRNGLFHGGGWYLLGVQTLTILCEVTWAALITFILLFIIQKTMGLRVSPEDERLGADLVEHGIMQKTDGSQLAFTSQNTPVAPTVSQLIPNLHAMTGIKSTKLKSGITERKTSLFTVVRSLPENSEDAGSESTGSSSVGTALRSATSRESSEEDHTTTQALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPE4</accession>
    <name>A0ABM1VPE4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FMRFamide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101864656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824286.1">
        <property type="nucleotide sequence ID" value="XM_035968393.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864656"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="80"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035824286.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38442" checksum="9C654E47E3D43112" modified="2025-10-08" version="1">MSNCGDVNNVSDINNINSTATRGCYLEKPNSVVNESDIWPWRVGLYGIGGSCIACVGLVCNSIAVLVLANYGVLYPTPRIARTCASYTVVLITLERYIVVVWPLSAHRLCQKRVAIGCVVGVVVFALCYHIPLYMAYSCGDVWDEESDKWRYIMYRTSVGKSSWFNDVYVTYINLALHFLLPFLILLTFNSLMLWELWHHPGVRTGLNETDRQRRARREQRLTGMVVCMTVIFFLCELFPAVSLILTSGLNTFVECSQECNRSVHQAMAGSVGGSRFSAVADTIVMVNSAINFAIYCAAGKKFRAVFITVFCGRRRREQTADSSHCVNTGTAMTRLSRQSGHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQI6</accession>
    <name>A0ABM1VQI6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Mucin-5AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101852839</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935796.1">
        <property type="nucleotide sequence ID" value="XM_013080342.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824678.1">
        <property type="nucleotide sequence ID" value="XM_035968785.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852839"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824678.1"/>
        </source>
    </evidence>
    <sequence length="645" mass="66614" checksum="287E7B22C5F5E9C8" modified="2025-10-08" version="1">MVSPRCPTPFSEASAAPNRFMPIHSSGVMNTSLAPHDSYIQPIRPVVTLASVARQRGTQQTLYRQSSAHPSSVTAPSGLESTTDSAMSHVVATTSAPGTLRSLHESQAPSVVGATDGSVASSGGITCRSLPQQESPALVLSLSGNIGSMSGRGLQTVWGKEQTVATSGASSNLPRTSSVSSQPAVANVVGAATPSQSASAVARGQGEGRGVMKDVELPGEILPSYEEAVMLLTGHELEAFKKHREQGGTGGPHSLSMALDNTTQASGRSQSSTGGQSWSQTTPQPPQPSTTTTATSTSTTTVAPATRPAPRAPPQHNSPGTLPDPGRCPFSRQLAMLSGRTQPPTPGQVGQTKVLERSPAPPAKADSCPSLKAMLRAPPFALSVNRTNPASQVPPTVGPAPTTQHQLAAQGARTGATRSTGQRLVGGKPRDKSSSQRDQSPLQVSVASSKLEPSSNASSRNSPLQSQSNRLTWSSSPRGSHPSLNPTQSFTVGKPTLSSQLSGQPQAVSARYNTPTTFSRQVVQPPTNKPHPTNKQRPTAGHTPRKASASDLPSANYAGTAPNVDLTKTSLAMGFAPPTTAAPPTTAAPPTTAAPPRQRAATDVGPAPANSQINTDDLQATLEVLKSLDSQYFLHNDEDSNSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQL7</accession>
    <name>A0ABM1VQL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calbindin-32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824709.1">
        <property type="nucleotide sequence ID" value="XM_035968816.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850945"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051001">
        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972:SF10">
        <property type="entry name" value="CALBINDIN-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="260"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035824709.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36369" checksum="0A7C8B6C43DCE9EA" modified="2025-10-08" version="1">MATSAEKSGATSQNFLRQFRDKKTRKFREISASSFMDVWNHYDSDGNGYIEGSELDQFLYELVTSVNTQDVGPEVVSQAALKEAKASILSAFDENKDGKIDIAELAQLLPMEENFLLLFRREHPLESSVEFMKTWRKYDEDHSGYIEADELKHFLKDLLKSFERTVSEEQLITYADTMLQLFDRNKDGKLQLSEMAKLLPVKENFLQRPIFKGAKQLTAEDISRVFNLYDRDGNKSIEDEELHGFLKDLMELVQEDYDADDIEEFKDILLRECDINHDGRIDKDELSMVLVSFAKASQGPEGEEGGEEAAAKDGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTE1</accession>
    <name>A0ABM1VTE1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cholesterol side-chain cleavage enzyme, mitochondrial</fullName>
            <ecNumber evidence="5">1.14.15.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">CYPXIA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Cholesterol desmolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Cytochrome P450 11A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Cytochrome P450(scc)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC101854797</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; C21-steroid hormone metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.6" evidence="5"/>
    <dbReference type="RefSeq" id="XP_035825683.1">
        <property type="nucleotide sequence ID" value="XM_035969790.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854797"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF3">
        <property type="entry name" value="CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8 25" id="KW-0349">Heme</keyword>
    <keyword evidence="13 25" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14 25" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="20" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="28">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00032666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00033274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00033394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_035825683.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39707" checksum="CB571153275CDF07" modified="2025-10-08" version="1">YLIRSQGEEWYKQRTVVSKKMLKLGEVSNFSTEMGEVSDDFVSRLGKIRDVNGEVPKLERELFKWAMESIGTFIFEERIGCLGDQPSSMAQSFIENMEGFFKTLQPLLYNLPFYKLWKTQLWQEFESYSDNIMEIGHHMVEKVRLYWVFAVIIYTSTATTWCLYLLAKHPEVQERLLSEINAAADKNGDVAADVLCRLPLVKGVVKETLRMYPITYSTSRNMTEDTEIGGYNVPAGTHVQANLYGMYHDPALFPEPESFRPERWLRENSGDMDPTVKAMSNLVWGHGARMCIGRRVAEQEMHITLSKIVQKFKLSYEHDDVEPVLNTMMTPDRPLRVKLTPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTK5</accession>
    <name>A0ABM1VTK5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477708</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825747.1">
        <property type="nucleotide sequence ID" value="XM_035969854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477708"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035825747.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25404" checksum="0E29C007A5F8ADDF" modified="2025-10-08" version="1">MRNVTEKCPGLECPKLIRTRLLRKYLATTIQLLDMTGDELKMVADHMGHSVAVHTDVYRLQSSLLEKTKVARALIALENGNLTKFAGRNLASMPVEELPLPTADREDEEEDDLEPLNVAEESGSEHTGEDAGQPGAAVETLEDVGTVDDRLSMSEKTKKPKGRKRWSLEEETSLCTQFKENIVTKTNPSGMQIRQAQEKCPFLKERSVAVIKTKINNIILGKCKLSVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUF5</accession>
    <name>A0ABM1VUF5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101855388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035826047.1">
        <property type="nucleotide sequence ID" value="XM_035970154.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855388"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF243">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="280"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035826047.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="34439" checksum="533DD0245E576FAF" modified="2025-10-08" version="1">MAEATVAPPCNTRFFCHECRSEVRPNIPAYTCSRCNSGFIEEMESGPAAQPQSSASATPTDPAVQFAEMLSNAFLDPLRNSGGPGTMWGTRHRYNTRQASQAPRNPTEDTEESEDDDMRGVAPSAVFHFTPGDLHQPGQQTFHGIINYMIQRLGSDLGGGPPFVHLHGNPGDYAWGTGGLDAIISQLFSQLEGSGAPPAQKEKIESLPTVTIDQSHIDATLQCAICMDDFELYQKVRKLPCDHMYHSECIVKWLEMHGTCPVCRKDLNGEDTSTNEVDFASVFPRNGDDGQGASSSSSSSSISMGPSGSSSSSMDDHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW08</accession>
    <name>A0ABM1VW08_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-cysteine desulfhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826600.1">
        <property type="nucleotide sequence ID" value="XM_035970707.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850732"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826600.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31008" checksum="434EE3469777AA7E" modified="2025-10-08" version="1">MPVEEMVQMCRKRNVLSFIDGAHALGSLEFNISAIDPDFYVSNAHKWLSCPKGAAFLYVKKSWQEMIRPAVISHGLGSGFSSEFIWSGLHDYSPMLSLHTVLDFWLAVGPQNIRTYMHKMAQEGASVLTKSWETRLAAPAEMFGSMVLVELPASIHSMFQTLDYSAAESIQNSLYHDYNIEQKDKMFLIASDVRVAVAHLVHQTYIPEETLSILIDAQCLCLKICSHRKTNRQDLPLPNQVSIISMCKQEEVTDVWTNPGEYSRFVNWNGPQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWN2</accession>
    <name>A0ABM1VWN2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0489 protein C5orf22 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0489 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826824.1">
        <property type="nucleotide sequence ID" value="XM_035970931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860425"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024131">
        <property type="entry name" value="UPF0489"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225">
        <property type="entry name" value="MISEXPRESSION SUPPRESSOR OF RAS 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225:SF3">
        <property type="entry name" value="UPF0489 PROTEIN C5ORF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12640">
        <property type="entry name" value="UPF0489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826824.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="46517" checksum="60D9DC8E91DA1DB5" modified="2025-10-08" version="1">MAQPRKCKKLPVCIVEPHNEVLPFIHRAIASRRLPFNNVPILHFDSHPDLLLPINLKADIVFQPQKLYESLSIENWLLPLAYAKHVNHVIWVKPPWAQQIQSSEQNFSIGKCSQSGNVRLSCKENYFLTDGLFQTVGKLTNTTDVKLTVVELLPEKWSQFDPGYCDTTNTSGGTIPIPSQTDWIPTLLDQLMDQPYILDIDLDFFSTANPFKDMLKPEEEQALTRLYHYSSPSDSTNDGILSFTKTRQKQLEKLERVFSSLESKWSDCEKVPSLKELEAMTLTELVGMNPININWCDENVQDLRLLTHAVILEGKSRDMTFTNLHDYGCTLDDTELPHHISTPEQLEVLHDEFSLLMERLPRPAIVTIARSSDDDYCPKNQVDQCQTKVLSVLEHLYGSLDITSEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWV6</accession>
    <name>A0ABM1VWV6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.22" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035826898.1">
        <property type="nucleotide sequence ID" value="XM_035971005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857263"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF68">
        <property type="entry name" value="HISTIDINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="593"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035826898.1"/>
        </source>
    </evidence>
    <sequence length="764" mass="84547" checksum="583E64772E1E26AA" modified="2025-10-08" version="1">MCLFIYSCIYFPGKEMVDYIADYFLDIRSRRVFPDVQPGYMQALVPDRAPEEPNKWEDIFADVERVIMPGVRQRLVDRSMLADAASCLEFTWASSPACTELETIVMDWLGKMLELPESFLHGEKGSRSLGGGCRSEKLWLHLDAAYAGSAFICPEFRSWMAGIEFSDSFAFNPSKWLMVHFDCSAMWVKDARALHRTFNVEPLYLQHENSGTSPSTPQHWQIALSRRFRALKLWFVLRSFGVSGLQRHIRRGVELAQMFENLVQADLRFEVTAPRWLGMVVFRLVSIQVNERTMIADVCHCQRYIALDDDGDDDHVSFRDWITITDMASKILIEAGEQADESIEENDEEDDDTSEAETTQMSTNSNKEEPPTLQRVPRKNAARSNGLTNGEAHLCRPRPLPHPLPHAKTASLRRKEFGISLLLSNVPMSPKVVNGSFAALYDDNDVGLEQLAGQLSVGGEFIRLSPRKRGKLSEKDRQRSLDCSFLAYRRDNPIKMKMMGSLDSKIDDILEMGSKVAGGGDDSDGETAEGRKEKDKEEDDRREGKGKVDEEGKEVDQAEEAESNEKSFSGKNVVGAKKGRVIEVPTVTKVKVKMSNGGLVKGEGTSLEGRVLEQERWDTGHRGQKGQKSQTGQEKNTGVKNNEIAKVASAGKNSPQKRDQKSNTASENQNSVGDHKMVLKASKSSELPTKSKNSVGGSNPDAGGTGGRYMMELSKAVCSKVKEALLTLPGSGGGNSTPAAMAGDGDGDVCCPYCGRELPSSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W035</accession>
    <name>A0ABM1W035_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101859812</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_035828028.1">
        <property type="nucleotide sequence ID" value="XM_035972135.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859812"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14002">
        <property type="entry name" value="STKc_STK36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983">
        <property type="entry name" value="PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1305"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1307"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035828028.1"/>
        </source>
    </evidence>
    <sequence length="1360" mass="151264" checksum="83C94065DC39977E" modified="2025-10-08" version="1">MDNYHVLEIIGEGSFGKVYKGRKKFTSQIVALKFIPKMGKSEKELKGLRREIDIMRGLKHTNIIELLDSFDTDKEVVVVTDCAEGELFQILEDDASLPEEQVRVIASQLVSALYYLHSHRILHRDMKPQNILLGKGGVIKLCDFGFARGMSTNTMVLTSIKGTPLYMSPELVEEKPYDHTADLWALGCILYELFAGTPPFYTNSIFQLVNMIIKDPVKWPKTMTPVFKDFLQGLLNKNPRHRLAWPHLLHHPFVAEMIKVNEEDLNLPSPFTQPLTASMLVLKEEQTKVKANPPGTSKILARARRKAMEEVEKKREKQNRLQAWDQADGPSGEEVKDKDLESSEASKPKLPEEVLEPTPRPDRISKDYKQEYPSIEVEGRTVLNKKKKKEEPSNNMENVKLDTEEVDSEDEWQKLIDVTDQEGDPDYTLRLLDDAETIGKLKLRLNSSSDQVRDCMLEGASRLRSVLRVITNIVTLKCDVRKIVAFCNALDLPDKLLSLLQDVLKATKVKQQPWAQQILNDLVITVNAYFASEISWADWSQAEGKDKQVVTHYTSAIHRFWSLVPGLVSEDIDEDLRLLEQTLLCVVYLSEASERGRIQEPNAYFSSVATDHLESLDALLTATQGDPAVLKRLTEIAEGNMEAATERLEQMTLHAISSLASLTYVSHEATGPKDGKQKIATYLAERIMKSSDGVGYEFLILLRHPLHCCSVLKVLYSCCQVSTDLCQFLHDRPEHVESLLGIIMGKVDLADMEVNTVVEMVLYTLGVIVIHNQAMPQPLAEAAAIMVGLFLDSTLASHTAAAALLFSQMVTCGVNAEVQPFDMLQASLAVFTDLDQVCARFLTHTHTYTHLICVRPPFEYGVLDGLLMLLCELLGGAESPVASLYIESGIWGAMWHRIAQGTQVLNPGTDMPIHDMETGMSSDGVRASHKFSAPDWGLISPQGLMASLQMAVAVFTKETYQCLPNLATSDSILMLTLVHFLHPRFLEEIHSHFHEEGDQLVEDIILAVTQMGCFPFAVDTTVELLAEVQHCLYMSKFLPRLLGSCVRYLRGATLETPMGLVARLVLGNVIFVEQFATTINECKAVGFLRSCVDSRSPLSVLCDAMSICSHLVRSSPEHLQLVTNVFKGPDNDFSLLVAFIKHPTAAVKSRTCSLLGNIMRHDAQMYPTLKRREQILDGLVMCLKDTDSNVRKCAAYAVGNASYHSGELYPRLRPALPLLLELLRDPITKTRANAASACGNLGMHSAVLCPDIRKNKLIAHLLETSCHDAHSVVQTNALLALRSLCTRDELKKDLMSLNAVDKLSALLSPQTPRNDPTTPRPYTGGSRPGTALSNRPSTAAVNGVATCANKLLRLLQTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0F4</accession>
    <name>A0ABM1W0F4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Urease accessory protein UreG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828147.1">
        <property type="nucleotide sequence ID" value="XM_035972254.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850201"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="67"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035828147.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29213" checksum="8082DD74D43DFB8F" modified="2025-10-08" version="1">MEDATANTFKFVKGGAVVPPPSELSHSHDHGNGHTHGHTHDVMENPGTFTDRDLPIYRSDWKQRAFTVGIGGPVGSGKTAMVLALCRHLRDKCGVCVVTNDIFTKEDWEFLVRNEALVEERIRAVETGGCPHAAIREDYSLNMAEVRELTQKFHPDIVIVESGGDNLAANFSRELADYIIYIIDVSGGDKIPRKGGPGVTQSDLLVVNKTDLAEAVGASLEVMSRDAKLMRQDGPTLFTQAKHGVGVAEVADHIMAACRRQSGQSRASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W151</accession>
    <name>A0ABM1W151_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-Fucosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101848385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035828394.1">
        <property type="nucleotide sequence ID" value="XM_035972501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848385"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828394.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44291" checksum="91A4BD3A08068BC3" modified="2025-10-08" version="1">MKILPPDNVRAETDGEVEVAQSSLDDCQICTVERDYESSLQVLDTKLDRVIYRKVAGLHKLQIKPVTLIELKWEETQSKTVPKHVNHSSDGQTQGPTADALKGNETRQKKEKEKESTGNCPLFVSTGLNGRLGNQMFEYAATVGVARSQGRIPALLTRTSDMQNAFQITHARTFNTSHGCDRWQVVSGVHFGIFEIRLTKLPEKNITMSGFRQSWKYFESAQDELRKEFRFKDNISADAKNLEAEIRRKFPNRTLVGVHARRGDFMTHRKLGYYTPAPSYYYKAFDRMIKEVAPKTSPLLFVVSSDDLKWCAANIKRPDVHVLSSASPQLHLAFLARTSHAVISAGTYSWWAGWLTGGKVIYFSGYPGNGTFLMNDFKAADYYPPHWIGIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W185</accession>
    <name>A0ABM1W185_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Run domain Beclin-1-interacting and cysteine-rich domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101849005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828428.1">
        <property type="nucleotide sequence ID" value="XM_035972535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849005"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17686">
        <property type="entry name" value="RUN_RUBCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052428">
        <property type="entry name" value="Autophagy_HostDef_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048569">
        <property type="entry name" value="RUBC_PIKBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971">
        <property type="entry name" value="PHOX (PX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971:SF1">
        <property type="entry name" value="RUBICON, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21054">
        <property type="entry name" value="RUBC_PIKBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="6">
        <location>
            <begin position="36"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="778"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="867"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1294"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="896"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1312"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828428.1"/>
        </source>
    </evidence>
    <sequence length="1327" mass="143901" checksum="2A80FDD5997BD2DE" modified="2025-10-08" version="1">MADSETDHESDCRDLLIKLKRTTEGLLAGQSMQGVWGTYGGLRRVCDDTEAILGHHVREDQASSASEGNYWAFVQGLKWLSPSHAPIIERLSRHTGRQRGQYAEVGRAWLQDSVQDHSLISQLDILLASPEHLHTFYYDDAFLRQEEYVAAMRICFRAIELNKPALLSDINPQLLRSDRLPGSHPRSSSLPLRQQSRADGKSSFVHHQHSFPCPGSEPTRYSMGNRLSTRLEVSYTGLEFSSTQSLAFDPALSGLFGPINQKSPSDPYFLTSALTAPPTSAGVFSSTGRDQDTAESVEQTEPSSSDGGLLHPNSTAVPPSSSSTSSCGALQPPSSSSASSSEMPQAGSNSSFEDVTNEAVKLLQQGSGQGGASDSHQPSVHSSEQNEPHEESSTLSAASAHSSFSEVGSDSLVSTSIVSELGQGAGFEQQPSEHVSTSRSNSLISVGIDAEALNHGLVNEPLTASKVSNLGPLSNGDGTSALGNDSQSEHTTNKVYFSHGQRASVPSVFPGISDTSAFQHDGSETKLAAVKSDPNLASRGDSRLSQRSKLSVPSAVGLSPLSMDTASDLYQTTSPAATPSPSPGALSDRSSLRSSGLVYIPPPLSRGTSLERGLSLQSDISSNSSGPGGSNTGSSTSKAAHPPPTTATRRMGHKRWVSDTSVIQLQSPGEARAVEAEPATRTTPTNGRGQRASESDTASVQPVGGHRSSGNRRTRASGLEPSGYSQSTLTRPAEGQSLMSYLTSQDFNTCANLEKENAHFHISEALIAAFESMRWNKAMKKQSSGRHSSSSSNSDEEIQELRQRIRIRKQEKLMEKGRPFPALSDGQTDTATSSQSVSSHVGSSADVSSLSGEYSSVVLCNDPCSHSSRLRSISRGEKKNDDRLIGEKNGVLPFTETLNSTVHTDSPSVDDTSESGDDDVDHGQIDLNMSSDAQGSLLALRSGGLSLSMASLYSELEIQKSNQQLERNSSLEDSVTPGSAESIAISLLRKFSEKHLPKASELKWLVSEHDAPQRLLPLPASIPVSPDDGEDSNGSRTNRTRLRGNLEWAPPRAQIIFSIHPTEKRAVVMQRQNYRCAGCGLRIDPAFMKRYRYCEYLGKYFCQCCHTSETSVIPGRVIERWDFSRCPVSRFSFTLLEKMWTEPLFHIDTIHPGLYKRVRSLENIRQGRTQLHHLHSLLAVCKRDVKLMKEAQKLPAHWISNHDVYSMDDFSQVKSGVMLTHIKSFVSSAIAHVDACPLCQGLGFICGMCNDPQVIFPFQLATVTRCTVCQSCYHKHCFIPGKCPKCIRMEARRQRQQEQLSPDSPESEDGHSTSTLTPETDVTVHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1X4</accession>
    <name>A0ABM1W1X4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101859978</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101859978</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828667.1">
        <property type="nucleotide sequence ID" value="XM_035972774.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859978"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06631">
        <property type="entry name" value="STKc_YSK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="2223"/>
            <end position="2485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="694"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1507"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1632"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1796"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1858"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1898"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1944"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="2253"/>
            <end position="2280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="813"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="901"/>
            <end position="915"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="925"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="962"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="979"/>
            <end position="991"/>
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        <location>
            <begin position="999"/>
            <end position="1035"/>
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    </feature>
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        <location>
            <begin position="1057"/>
            <end position="1071"/>
        </location>
    </feature>
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        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1167"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1216"/>
            <end position="1226"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1253"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1304"/>
            <end position="1323"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1324"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1362"/>
            <end position="1418"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1523"/>
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        </location>
    </feature>
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        <location>
            <begin position="1540"/>
            <end position="1551"/>
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            <begin position="1558"/>
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            <begin position="1571"/>
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            <begin position="1800"/>
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        </location>
    </feature>
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        <location>
            <begin position="1820"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1869"/>
            <end position="1883"/>
        </location>
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        <location>
            <begin position="1898"/>
            <end position="1909"/>
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            <begin position="1961"/>
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        </location>
    </feature>
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        <location>
            <begin position="1971"/>
            <end position="1980"/>
        </location>
    </feature>
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            <begin position="1994"/>
            <end position="2004"/>
        </location>
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            <begin position="2027"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="2251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035828667.1"/>
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    </evidence>
    <sequence length="2498" mass="270953" checksum="30C51CD8C2D12FD2" modified="2025-10-08" version="1">MRECPRGEVVAAKVKVTPVRTEVMNSGSSGGGGGGGGRPLASTSSTSITSTGQGQGSAGSGLGQGQGRGPPSASSRGNSAKYYDIASTILGGSGDVELVLLNAAKNGNYSKLEQLLEKRKEFHLDINCKDKRTGNTALMWAAKRGHSRTVEILLRHGADPTLCNYEAQTALELAFSPVKTVLLDWVENSTELTSRRLLQAAWQGNVAVVRAILDSRQISDVNCQNAEGLTPLMLVSRDVQLFERLSVQLNRHYSPVEVAAELMKANANIHVTDNDGRSSLHYASQSRAGVADRLVTTLITGGMDIELQDKRLFTPIHLASQLGNTDNVVALLDGGSEVNIKGFGGLTPLHMTAFNDHHKTAVTLLNRGADVQLVDDRGLTPLDLAKTRKMKVTLKEAWTEATKVQATEAGPETTTPNNKQTNDGPSKKKSAPPKKKPEVIFDDLVSSPAKTPAPTPKNGVKILSNVERCKQAERKILQEVEALKAAHPVLQRESTRMLGTTRSKILPQIGRSTSPEYSQSQGHDRESPRLSADSVLTSLEDARHQLMSRGRSMSDIKLGVGRQSMPLSSPWPADEGRLDEIRTPVSSRPRKRSKNRHRRSGSDPPMPNMADLAVSCDHFLPSPHQQRNSEVEGGTPKSSQKLSSTAPEPVTFITQSSSPLDSKGYKDFSRLDSPFELLRSRSIFKEEFILEESRPREMHSGSYPTSSSGSSLSSSSPRDQPSVPHSPGRSLKRDPSLSTLQELHASGAAKNSPVDKNQNFVVSKDSENCIPVIKEQSQRVRRKSENSALNSRTRVLRIGPSSALKHAAKGLSSDENSNVLQDGSGSTLGTPDQTSLMRKSQSLDNVSPRFSSPQTSYDEPLSQRFCLPQGSSRKKQPSASKDTSPKEPVSNENTSRENSLKKSVSNETSSQNAGSRSVLEKSKASVPNDNAQTLNAAKSSAQKPVAPFSGKIRVVQSTEMENWDKDFIFDTEPSEKTKQSSQASKISSGKSRAALALNKSVQNPQQGTPSQRSARKSSLTSKSYSGPLSQRSSGTAPAGESDKRPQTSCNDTGVARDQGREDASLTEREQTFSDMQSMPPQPGRPPLSAKPAFVTQVLESSQESTADNSQEDPVASNTAASIGRKDAGAYGKNTHSRPGGMVSSKSTPNLRPKESGSRGAMFVVTEESERKGSASKQRQEERAAIAKQKAKETAQLNSPSVREGLPENSKTESVKAKLSNKAAAAKEPVVNKGCESARVRSVNKAASLEKTILTHQTKNSALTSQQTKAKSPLENSANKVRSSQDSLIGRNNKSSMVTKVNPPSTSETSSSRTNASASKNKSSVQFSMSNRGYEQNKAGQAVKEAQPSLPASGTRQKEKSSVLPTQNKQSVSKSVDSTQQAQSQQKPKESSGSAPSKQQLKPNPNTAINPDPQSQSHQSKTEEKSVITTSPIDPNIILSPRKNEPLVKIKFLSHTTTPSSPQSIAETADVTSSTYHHNAQAISTPLIVNPFENFLQAHIKTVENSSKDAVVKMKKVPRGNTGGSNKTSKKSSINSSSNKRPTSGGSRQNSAGKKLGTRGKDSKSEKEARPKSCKRGRGISGKKKKQPETTATEISSEAQKPDVALISGIGWQLSTSCIDKSDVKVNDEIDLHSSDSEWSNEEDSRATDGPVTAGRSHDNLLNKHMLEAFKEKITLNSPRFLEMKRRQESQLDLKLPIVTDDGFPPMNLDMTQHSHNQAHARGETELHFGLEHIGESEDVLCDMTHVGSQHNNDIQREILMGKLTPIPEVSMLSKTAEAITEFDKTVKDSQLAELLGETSSRLDHHEREKEKKRSANKSRYIKEKSRSSGIEEKTVRNDAIHYEYTASGKTIRRTQSLKEGLNVQRPRRERTFSETKDDEKRDAAEEEIDEAIEEILSNTTSSMNSTLRSVTHKLKEQPHSGAMSLTDGDRSILLKLKSSSSPFHARSAELNSGVATDHQQDVGSNSSTSRADLEVGDRKQVSAAKQNSHDKSGAKSSAQNTVSSARAKESVAENSGKPPVSVRASRSKQPLQRSASLRASQESLAVEPVMLTEEEARQLAKVMNSFRHMELHASGHVAEGTGGSAKMSSRQGKGSLVAAAAGDYNLVPRPASTGAAASSKVKGKFHELKQSVVVSVAPREAGSSGQASKKAKDVSVDKQVVMKEEESLLECIADINVAPEVMAQAPSLQQMCEQLSVRRGSLAGSECTVDSVQSTPVEETIQWKKGNILGRGAFGTVWCGLTNEGQLIAVKQIELTTKDIPKAQHEYEKIQEEVELLKTLEHINIVGYLGTSLEESTVSIFMQFIPGGSIASILARFGALDESVFRRYTRQILEGVEYLHENDVIHRDIKGANVMLMPNGVIKLIDFGCAKRLCINLSISQTEILKSMKGTPFWMAPEVVNETGHGKKSDIWSIGCTVFEMATRKPPWADMNPMAAIFAIGSADRPVPSLPEKFSLEARDFISECLTRDQEKRPSASQLLDHLFITRRNSRRNSKTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1Y2</accession>
    <name>A0ABM1W1Y2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline-rich protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828675.1">
        <property type="nucleotide sequence ID" value="XM_035972782.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845202"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828675.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="36108" checksum="3B329EBF01A240F0" modified="2025-10-08" version="1">MTAQALIEHGNSLADISSSLQDASAAPQSSYVTSISRLLLVWLPSKGSQDDLQLGVLSFSHALALREAPTVDTRLDRVDNFPLHADRNDANARLETKTSEVSCVSHDYIITADPLLKTPALLGPSEAMNSVIFLTALCVAVATPALVKRQAPQNPPPPVNGANPAPQQPPFPFPPPPGNGTLPQFPPPPPNGTRPPFPLPPPPSGPFGPPPPPRGPYGIPPPPPGRFGPPSRGPLGPGQFPPPPFGQGRGQQGRFPPPPFGQGQGQQGRFPPPPFGQGQGQQGRFPQPPFGQGQGQQGRFPQQPFGQFGSQRQPNFNFPQPPQGGFQFPQGFPQNGFPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W212</accession>
    <name>A0ABM1W212_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cryptochrome-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101845146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828705.1">
        <property type="nucleotide sequence ID" value="XM_035972812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845146"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828705.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="59609" checksum="7F964B557EFD16C6" modified="2025-10-08" version="1">MGKHRAIHWFRKGLRLHDNPALLKACEQASELYPIFVLDPWFASSPQCHVGCNRWRFLLQALQDLDQSLQSLNLRLFVIRGQPEVEIEKLCQQWSITKLTYEADTEPYAVQRDAKVEARMEALGVEVIKCVSHTLFDVNLTVKNNGGCAPLTYQKFQSVLSKMGTPAKALLSPTLTDLEGCKTPVSSSHDQYYGVPTLEELGKSSSDCGPLLFPGGETEALDRMERHLKKINWICNFEKPKTSPNSLSPSTTVLSPYLKFGCLSPRLFYHRLQQVYSGKKHSQPPVSLHGQLLWREFFYTVGAVTPNFDRMKGNPVCRQIPWGSKPEHLEAWTEARTGYPFIDAVMTQLRLEGWIHHLARHAVACFLTRGDLWVSWEQGMKVFEELLLDADWSLNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPNGDYLRKYLPVLKKFPAKYIFEPWLAPSSVQQAAGCIVGKDYPRPIVDHDRARQENIKKMAAAYAAAKSSNEGSPVKTSGGGKKKLSTELDKQPNKKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A161R9N0</accession>
    <name>A0A161R9N0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Betsin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC101857558</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101857558</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>Identification of neuropeptides in Aplysia californica.</title>
            <authorList>
                <person name="Kohn A.B."/>
                <person name="Citarella M."/>
                <person name="Moroz L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="GU973878">
        <property type="protein sequence ID" value="ADX20592.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005096263.1">
        <property type="nucleotide sequence ID" value="XM_005096206.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005096264.1">
        <property type="nucleotide sequence ID" value="XM_005096207.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A161R9N0"/>
    <dbReference type="GeneID" id="101857558"/>
    <dbReference type="OrthoDB" id="6060727at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007825730" evidence="2">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADX20592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005096263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005096264.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16293" checksum="BEB21A1D184D4EC4" modified="2016-07-06" version="1">MEPQLLSVVILVLCACAASALPTNSRREDLSHLVTLLGKLKNIERARQNSEGSAQAHAQEAWEGPRVSSFPETEVTADVIPDEVSAAKGYLGQRPATGVVNKRQGAWSYDYGLGGGRFGKRSYGDYGIGGGRFGRDVDHVDLSDATENEITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JB91</accession>
    <name>A0ABM0JB91_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 74A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089685.1">
        <property type="nucleotide sequence ID" value="XM_005089628.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854681"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089685.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34828" checksum="E150103BBB03D697" modified="2025-10-08" version="1">MEGRKRVLITQAESEGSVSGSSPTQDTAFSDVQEGTRERSTRAGSGTHHSQFSHDSVYSEGRYLEPSERGYDTGDDTGDDTISIVDSRRRNESLYDDVLEEEEEEEEEEDENNDDNNSMEGWDVSQSDSSDDEDESVHELRDSDYDTDLDMNDDKYLHPEKYDHDTTGMAKYLKACKELGLQPIRYFMKHMQDEHLKLRYHGLGPSAMKALAAPLECNTAIEHMDLEGNWIMAEGTVHLCRVLRENVFLTELNLSENKIEDEGATTVCKLLIENRTIERLELAGNNISDHTGEILHELLTVNTILNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBJ8</accession>
    <name>A0ABM0JBJ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Limbic system-associated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089888.2">
        <property type="nucleotide sequence ID" value="XM_005089831.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857847"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047357922" evidence="5">
        <location>
            <begin position="48"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="52"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="158"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="259"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="373"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089888.2"/>
        </source>
    </evidence>
    <sequence length="469" mass="52364" checksum="DDA583EDFF5CF6FF" modified="2025-10-08" version="1">MEYLDVCSACASKFLSCGVRDVTQRALCLVFVLSILLHGQAVRSATAEDDEPQVTITHRINENKDAELICTVKDLGSRRIIWSKLSDPYPISIGTTRFMPNKRYRVEGKSREAVMLTIKRVTFQDAGEYQCRVSGLEYLAEIISLNIPSGSDSTRLVPTETEVMAEVGDTVLLPCHVENLNTRLVLWKDDRNEVVSLRKKIYNGDRRFDVVHGSRTEWSLQLRDVKPSDFGHYTCIVNSRPVLTRTVALKNSAPVEMAPVLKRDTNYRMKVEADPGETVTLTCNFRANPPATVTWYKREVVGGKNTNQKVGVGSSLTLQSVTTAQSGKYICISKNGIKPSGRGRTRLIVKVPPTTVPPTTVPTTFVPTGPSSPHLYHHGKVTKQRRGSNVEIQCTAIGQPRPQIHWRRHGHRVENDHKYRVSSKNSGRHTITSTLLIRSLSSRDFGEYECVGYNALGLSQIAMEVTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBR2</accession>
    <name>A0ABM0JBR2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein GDAP2 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101864112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDAP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090008.2">
        <property type="nucleotide sequence ID" value="XM_005089951.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864112"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02905">
        <property type="entry name" value="Macro_GDAP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035793">
        <property type="entry name" value="Macro_GDAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF72">
        <property type="entry name" value="GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="3">
        <location>
            <begin position="67"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="364"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005090008.2"/>
        </source>
    </evidence>
    <sequence length="531" mass="61419" checksum="85AD2E8599C15B1B" modified="2025-10-08" version="1">MTCYLPKWWNKSRQQNELYSSRKSRDLLSKMDSLGTRDEIVEPSTITRWNFTKLLEQPRENVGEEDGSPFPWRNDLNAKIALWSGNITKLNVNAITHATNEHMNDRNSLSDELYRQGGQALFKEVQEDLRVCKTGEAKLSKGHQLPARYVIHSVGPRYNVKYITAAESALFSCYRTILQICKETEIKVLGLGAIHTVRRNYPPEKGAHIAIRTVRRFLEKHPEAIDLIVFACTEENLEVYRKILPLYFPRNSSEEDEALDHLPSDIGNEDGEPVIKERQIRILDKPTFAALKATDEEFEQTIDLNKEFAQSMALDVGHHPFANMEEDPDKVKSRHMAQQNTAEAKKLEVRRRYDRLLQRAKSEDLTDVAAYHCLYRTGVDHFGRPIVVFVGKNYPAQTADPEKVLLYLIRVMDPVVETDFVLVYFHTLTSGANQPPMNYLKMVYSFLDHRYKKNLKQFYIVHPTWWSKLATWFFTTFTASDIKPKVHSLKGVQFLYSKMSPDQIDIPQFVHEHDIQVNGARYEVPDTPEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC91</accession>
    <name>A0ABM0JC91_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101844967</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090364.1">
        <property type="nucleotide sequence ID" value="XM_005090307.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101844967"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="949"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005090364.1"/>
        </source>
    </evidence>
    <sequence length="1105" mass="122876" checksum="54B8441D19FCF8C7" modified="2025-10-08" version="1">MPSSRKAAAQENKVQVTLSKFFSSAGPKKTKSGPVISTDQNDDFQVIDAKATKRKSPNDADDLIKTSSKKPRPQKSSTSSSGGQSSKKSSEELIEQSISPGSSQDANGLTESKKSSDTSSSKTISASEKLQKFNLEENEEKVCVSDKVVTSKNCPVIDFTPCGDVVPPEVILNSDSEEEDKSSSSSSKRTASSKKKSSASFLSQFAPNKNKKTGSVAVKYTPLEQQFVDIKAQYPDALLLVECGYKYRFFGEDAETAAKVLKIFCHLDHNFMTASIPVHRLFVHVRRLVSAGHKVGVVKQTETAHLKAAGDNKSGPFSRKLSALYTKSTLIGEDVDSASGESDLSSTLPESHYLMCIYEQPQETAIKTVHVGLMCVDPATGDMVFDCFQDSTTYTELETRISHLKPVEILLSTKVSDRMNQILTDISTFSATKDDRIRIEKLDNDEFLHSQAVAAVSTFYSNDHTGLQKALKLEKPVISCLSALISYLRDFKLDKILSETSNFRPFSVRSSYMHLSGQCLRNLEVFANSCDGSERGSLFWMLNHTRTKFGSRLLRRWIAQPLLDKDDIEARLDAVEEIRRGDIDGLKKLKDMMIKMPDVERGLCSIYHKKSSAVEFFSVAKALEKIWKELLEIHRSAASILQSSLLKSLLSEIPELLSDIGTYSSAISEKAARENDKKNLFVDDNQFPNVCSRKKDIQEVMKCLNDHRKEVRLALKQPGLNFVTVNQIEFLVEVKNTQMKEVPSNWTQISSTKVVSRFHTPFIVKQYRRLNELKEQLVVDVTEAWQEFLEQFSLNFTKYKRAVNKLATLDCLMSLAKTASQDSFCKPVIDADNVHIDVTQGRHPIIDALKGEQEQFVPNDTELKASDTRVMVISGPNMGGKSSYIRQVALITILAQVGSYVPAESAHIGIVDAIYTRMGAADEIFKGQSTFMLELQEASDIMTQVTDRSLVILDELGRGTSTHDGVAIAHATLHHFVTQCKCLLLFVTHFPMLSEFHDMFPGIVKNFHMAFLLNDEENEGQSSAVEAITFLYQLTEGAAKKSYGLNVARLAEVDSDIIQVAALKSKELEAAVNLKMNSRDSFMALWNVNVSGIKEVVEHCTESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD21</accession>
    <name>A0ABM0JD21_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor Dp-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101846401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090901.1">
        <property type="nucleotide sequence ID" value="XM_005090844.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846401"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="10">
        <location>
            <begin position="165"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="9">
        <location>
            <begin position="256"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005090901.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="54108" checksum="A5CF53B09F0636E8" modified="2025-10-08" version="1">MANSNTTLASLWVDDGTGSPRKFTPMTPSKASSSGASSGNGNHSKEDFMQFYKESGLDSLARDVGILDPTGEIKGFSAEQQATSKPIQLVAVPIAQSPSKMSPFKIEQPHLLPKPSLTTRQIMTSPARPQVIQVDATSPWSARKRASDFIDADYSAEKRGKKGDKGGKGLRHFSMKVCEKVQMKGVTSYNEVADELVAEFSDPLNMLSPSDAVMPYDQKNIRRRVYDALNVLMAMNIISKEKKEIRWIGLPTNSAQECQHLEIEKQKRIERIKHKTQQLQELILQQIAFKNLVQRNRDLEKSQGPPASNSAIQLPFIIVNTSKKTVIDCSISNDKCEYLFKFDNTFEIHDDIEVLKRMGMAFGLERGQCTPKDLQRASKMVPKSLEPYVIDMANNSKPFQSSAVRPIDPSSATAQQARYQQQSTSQSSSSNYVNVMDTMDAELVTALSRQSSSGSYDQNYRAATDTPSVYSEDEETDSDRSSPVEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDA0</accession>
    <name>A0ABM0JDA0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101862551</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005091055.1">
        <property type="nucleotide sequence ID" value="XM_005090998.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862551"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="58"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005091055.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42846" checksum="A6D636ACF2895382" modified="2025-10-08" version="1">MEFESSSENLTLSNIGWGIIEVEPVKKAKILNDEMAHICYIVIKSFLYDLFAGFGIVTNIFNLYIFTKLGFKDTVNVTLFGLTLSDLGSLLILFWMGICHNPLFTYSDVHFDTLSVTYLSGGWPKLYFTRVTSWITAFVALERCLCIALPLKVKTLLTPRRACYSVIAIFLVIGSTMPPVYMTTGLDWKWYPKRNKTLLGLVFTEGKQGVYNVVVAINLFFTVGSFFFVIACTLILVINLKLKTKWRESVAGPPGKQAAASSSRDKRVSTMVVFLSILFVVCLFPGTVLFLVMIFEPDFNKGEAYHNLFTTVWGVCHLFEAANSSLNIFVYVKMSSKYKQVFITKFWCLRSCVMDEAEETKKFSSHQDSTRISSVSNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE64</accession>
    <name>A0ABM0JE64_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase</fullName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101850391</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="RefSeq" id="XP_005091641.1">
        <property type="nucleotide sequence ID" value="XM_005091584.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850391"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="15">
        <location>
            <begin position="45"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="176"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005091641.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="65446" checksum="69DFDA5801AC26E7" modified="2025-10-08" version="1">MTSLKRKSDLPPSGQNKRLVNEAGTDGDNNINNNAEQSQSTTAEKPSGFLAKLMAFILPACIEKARLEIFKTQIVKNGGKIVTEFDSNSNSISHVIVDDKMDMERVMRIMKLDTPPHVPVVKSMWLSSCLKSKCFLSFQEYELAAKKVSPEVLGEEQRNTSPVSFNRDAKSNVCLGALENGPQTSDTAGKQHFGRAGFVAGPSHQASTTTGDSDSDYIASDDDNDEEQSQAAQTSSNFPLSSQKPMVPVDKWICAQSSKSPKPNLNKHITDKLEEMVKAYESTNDRWRAFGYQKAVQALRRHPKVISSWEEAMALPAIGKRLADKIWEIAESGELRKLQELKSSEEVRVLETFTNVWGAGPTTAQQWFQQGFRTIEDLKEKAHLTHQQKVGVRLYQDLLDRMPREEAAEIEKVVREAAESIQEGVVAQACGSYRRGKATCGDVDVLVTHPDGRSHKGLFSKLLAKLKDSGFLTDDLVSAEDAGNQKKYLGVCKLPGENTKHRRLDIIVVPYSEYGCALVYFTGSAHFNRSLRHLCKKSSMSLNEHALKSGVVRKGAEKIYEGTVIPTPTEKSVFEALNVPYRPPEERDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE68</accession>
    <name>A0ABM0JE68_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101853761</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091655.2">
        <property type="nucleotide sequence ID" value="XM_005091598.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853761"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055188">
        <property type="entry name" value="Choice_anch_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052956">
        <property type="entry name" value="Mesenchyme-surface_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928:SF1">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22494">
        <property type="entry name" value="choice_anch_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Choice-of-anchor I" evidence="1">
        <location>
            <begin position="126"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091655.2"/>
        </source>
    </evidence>
    <sequence length="471" mass="51714" checksum="FFCE106C7BC1A719" modified="2025-10-08" version="1">MGRDFLSVSFESKDLSERGHVHFYQLLTDPQEVLLRLKTVTTVEGFDPKSIAWNSYCNELVVASMGKVHTINGVFEDPRPAVDILIPSFGLNVDRRSIPFSEGAIKGAGVREVFTKCDSGSHTAVSTHVQDIEPVHVTVDENNVAYMLFQTNNAIGRMDLKDPFAPMTYHNLGMKSWEQMAMDTSYEDGGINQNPHVINSLYQPGHAVAFTFANKTWLATADGGRIKQYSVRSGSTTLCNFDESADGRSWKQAFTSMVTQNTAAELQANLTTVTSRMRFSRLKSIQDGYNPLQMGYDYLLTYGGRGWSLMDAVSMQRVYDSGDLLETFYTSTNVKDNQKAMYNNYYTSATHTQTQNADRTSPMFGPNPTAIATGNINGTQVVAVANGYVGGLYFFSITGNSTQGPDVAFEGFERRGSPGLTWTESYKLDTDAVGEPGITDLIWISDAGQNVVAAVSSIAGAVSFYSVDVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEI9</accession>
    <name>A0ABM0JEI9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101851788</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091905.1">
        <property type="nucleotide sequence ID" value="XM_005091848.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851788"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091905.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="53245" checksum="60537F096705A81F" modified="2025-10-08" version="1">MNCRQELYYSRITVFEMSYGVIGPSSSSGSKQKESGAQLLARLSPRPCLTAVDPLIFGTLSQPKTSTGVTRKVIELYGSEGVGKSQLALHLAARTCLPPQVKGLSLGGLGAKVVFIDTDFKFSAFQLAVFLERLVLSAVESQSQSPDVGELKKNAESVEHQGTPCKKMKLDLDCLNENVEGNKDCNVKEKCDKNVESHQSTVKSNSTDPKLALLSGNCSSLSDKTQKEDIKPSNSYDDRTLETDFNVSNPEKGLYPQSESVVAKTKDTWNQKTQAGNSDEAVNSRVVSLSTKEVDHLVQQSLSNVQVLRVSSSQQLLVTLHSLQDLLLSDTDVSLVIIDSISAFYWHDKSSEPANMSCTEQKMKPVVEVISKLSSEFYVTFLVTKSALIGSKRKRAEDDFYQGNNNMKGTSADKTQHGSYLTEPQCEHVEFLGKSWLELQPKRIVLSRRLNHQRQTEFVASSPLWSSDRTFAIINDHLRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFQ4</accession>
    <name>A0ABM0JFQ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pleckstrin homology-like domain family A member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101859155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005092630.1">
        <property type="nucleotide sequence ID" value="XM_005092573.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859155"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005092630.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34507" checksum="15672DB9670780D8" modified="2025-10-08" version="1">MEPANNFLSHSAGLSLYPAITSSSILPPSPGAQDSVAARSALAVSGQNGWGNYGNDGLVPHNSCSMSSYSNLQLGASFPMNSKAAAYNAFAGGDYLNNCRQMQISSLGSLNGMGRYHPGLYGEMYQAGHPPAYPNGGFYPDMGAGLPPLPGRDLNCSSAQSDSSSGDSLDFLTSEATTAESVQFCLRLTNVTCSNDSVKVWFQNRRMKRKKLTERAKTRIREDQENKDHEPGQPQAAQQTHHHPQQQQQQQQPPQPQHQPPPPPQHPHHHHNGHHATNGHHPHPHHHHHHHPPPQHHPHSSHVQPKQELPSQPVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFU6</accession>
    <name>A0ABM0JFU6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein 10 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101859551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005092720.1">
        <property type="nucleotide sequence ID" value="XM_005092663.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859551"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17389">
        <property type="entry name" value="MFS_MFSD10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005092720.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="52917" checksum="500CAF9E5F867F9D" modified="2025-10-08" version="1">MIHEKGSSRADIFSMMKTRSGKTLSENGEGVPLKTDNNNDKQMNRTFYIIFFSLILDLLAFTVILPLLPSLLEHYSHHDESGLYSAIKNSVSSFRNFVGAPDTARWNSVLFGGLIGSLFSMLQFLTSPIIGAASDVYGRRPLMLICLIGISFSYVLWALSQSFLLFVIARIFGGISKGNVSLCTAIVTDVSTPQKRGKGMALIGIAFSIGFVFGPTIGAAFSRLNREEGNSVFFVMPALFALVLSVADFAFMYLYLSETLPSNKRLKSKRFLSQAAEYINPLSLFRFSSVSKLSANESTAVQSIGSIYFIYLFIYSGLEFTLPFLMHNRFEYTSMQQGKMFFFIGTVMALVQGGYTRRVTSGKEAKTAMRGILILIPSFILMAFVTNTVLMYTALTLFSFASATVVPCMTTLISTYGGDDEKGTIMGIFRSLGALSRAVGPVLASTVYWCFGAHVCYIMGAVFLIIPLAQIAKQQHCSKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGY3</accession>
    <name>A0ABM0JGY3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Metastasis-associated protein MTA3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101846950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the metastasis-associated protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093440.1">
        <property type="nucleotide sequence ID" value="XM_005093383.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846950"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04709">
        <property type="entry name" value="BAH_MTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035170">
        <property type="entry name" value="MTA1_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF29">
        <property type="entry name" value="METASTASIS ASSOCIATED 1-LIKE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17226">
        <property type="entry name" value="MTA_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="9">
        <location>
            <begin position="4"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="10">
        <location>
            <begin position="205"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="323"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="619"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="757"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005093440.1"/>
        </source>
    </evidence>
    <sequence length="787" mass="88654" checksum="35BEE09B82A0F24A" modified="2025-10-08" version="1">MSANMYRVGDYVFFETSSTAPYQIRRIEELNKTQNGNVEAKVMCFYRRRDISNSLIILADKHHNALDEEGEEKREIDDELAPKPDGETNGGPLSPAKDPVEENGTENNSPTNGSTNNNNNHQAGVGAGGLGMEEIPEKLRHQLKHRELFLSRQVETLPATHIRGKCCVTLLNETESLLSYLNKDDTFFYSLVYDPQQKTLLADKGEIRVGSKYQAEMIPKLSEGEGDVRKSEDLEELVWDPLHGLSEKEIDQFQIIARSVGTFARALDCTSTVRQPSLHMSAAAASRDITIFHAMNTLHQHKYNIAKAIQSLVPSGGPVLCRDEMEEWSASEANLFEDAIEQYGKDFNGIRQDFLPWKSLKSIVEYYYMWKTTDRYVQQKRIKASEAESKLKQVYIPNYNKPNPAAITNKLNGADGQVSGRACESCYTAHSNQWYSWGPVHMQCRLCSNCWSYWKKYGGLKMPTRLDGERPAPNQRQERIAQMNSIRMQKCTFTGCGKVSQRQEFKLKAHLNRHMATSHGMPIQPGSPRPVMKTRAAFCLVTTELTRISRRLCRDLLRPRHATRCPFTPINTSLIKQECQLRLSERPSYQQPAKYRTPATLDPVVARLGIDIKQEKPSLLLKGPNYGGGDRSSTPKERPQENVKVGSGHPSIMKKRGYEQTNGVDSGPAAKRPNMGVIRQAGTAIKTPGVTRRGSVLNHNSVNGRSRFCGKSMRMQLVGWMDNPDDVYFVATAATRKIRKQLQMNDFKRLARNPWKTLNVKPPLPSGSLSGSNGHRPTVPQEVVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIA8</accession>
    <name>A0ABM0JIA8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotrophin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094277.1">
        <property type="nucleotide sequence ID" value="XM_005094220.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856501"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094277.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13064" checksum="585A776C7FB7F742" modified="2025-10-08" version="1">MSEDKDQALVWKVKNGELSGIQSAVEKEGVNVNKAITGRLPLHYAADYGQTEVINYLISKGALVNAPDKYGITPLLSAIFEGHTDCVKLLLEKGADKTGRSPDGATYIDCAEKDDIKALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIZ1</accession>
    <name>A0ABM0JIZ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Solute carrier family 15 member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101862404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094746.1">
        <property type="nucleotide sequence ID" value="XM_005094689.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824714.1">
        <property type="nucleotide sequence ID" value="XM_035968821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862404"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824714.1"/>
        </source>
    </evidence>
    <sequence length="577" mass="64447" checksum="70324D51A01462A3" modified="2025-10-08" version="1">MLEASESESEPLLKPKKWSTLTISDDEFAKDARQRTKVNVKYEPKLSTFSPQKLAIIMCVLLVEMCERMAYYGVIANLVLYCTSVLDYTSNTATTISLVFSGTVYFIPIIGGYIADAWSSRFNVIFGSGLIYFCGLFSLLSSSIEYSSVFDDPDNEMQTEGRRTFYILGLVLVAIGTGGIKANVGPFGAQQVQDLGADAVQIYFNWFYFFVNAGGLVAFTAIAYVQQNISFAWGFLIPILSMFLALILLNVARQKYIYKEGEGSVLGSVFRICGQGICRQSPFIDGKRRMFDSARREYGGGFDSFTVDGVIAILRMLPVFFFVIMFWAIYSQMQSTYFLQGERMDLSLGSVLIPVAFLNAFNTVAVLIIIPVLDRLVYPCFKRLGRPLSYLQRIGFGFLLSASSVFLAGGVEIERKKHLGFHQVVGKESFYAANVSVFIQAPQFFLVGAGEAFTSIAGYEFAYTQAPKTLQGAIMGVFLATNGLGSYLSTAILAIVEAVTKDDPWFPDDINKGKAEYVFFLFGGLMILFFLGYIPIARWYKYQEYLTDEEVKAKAKARGPDNEQLDQQEYEHSNTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJB8</accession>
    <name>A0ABM0JJB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101850874 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101850874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005094964.1">
        <property type="nucleotide sequence ID" value="XM_005094907.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850874"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005094964.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34588" checksum="D5341768B60B270B" modified="2025-10-08" version="1">MPAAQDKAMVEKLVEQVRSYPVLYDTSMQEHKDAQLLRYIWTCIAETMGDTSLDGEGWKKKWISLRDTYTRRKRELVKNGPTASAKKPWVFYDLLSFLDEYPCGKRTAESDFPPISFQKEESESCRLETVSDDERLSAVSVCSPTTRDEQQGFPRCSSITSPVGRKRPREAGSTNSVDFAIKELVDMKRSQCAAEKEEAERDPDGDEAFFKSCSRRMKKLTPQARSFLKLQISQLFFNAENPTLPPMSITPLMHTFQPTTATPTGSYTNVIHQHTNILPQHAASTSVPSISNTGDLIRDAMNRSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJT4</accession>
    <name>A0ABM0JJT4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101855937</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095329.1">
        <property type="nucleotide sequence ID" value="XM_005095272.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855937"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1810">
        <property type="entry name" value="RNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041948">
        <property type="entry name" value="Rnl1/2_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA ligase" evidence="2">
        <location>
            <begin position="140"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095329.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47593" checksum="CB2E5973A9980DF4" modified="2025-10-08" version="1">MEFVGMKSIEKKPSFREDKCTDWVATEKVHGSSYQFYTCDGNRVICGSRRNQLNDEGSFLKCNTAEFKKRYVECVKKVFQIISSDERWAEYREWGKKEDNDDDNAEENDEEEEAGDEEKGDEENSETADNPTKSDCESSELKNKSNNIELRIYGELYGGGGVKSKLMSVAIQKEIIYSDEYRFYVFGINVNRKWLSVLQLGDLCREVGFPYFAVPVTEPKATLEELKDWLKDTGFMNSRSSLTERTDDYKTKIEGVVMTPLTRPDFGLHAVKYLSTSFVDVHERKDKAPNYCTKARYNSVLSKLDIPERQQTDMVIEMFIADILKESGAKESSNNETKSWTKSVRMWLMQDGYLEPTNEFEVAMVEKVRQGKPSRKDTELASLKMSESKAQEKVVDDEEDDDDLMDGAMGLFGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLQ5</accession>
    <name>A0ABM0JLQ5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101862407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005096634.1">
        <property type="nucleotide sequence ID" value="XM_005096577.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862407"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005096634.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25681" checksum="03D041477BBB7145" modified="2025-10-08" version="1">MNGTRLLRSPGVNDAKDGTCRIVVLGTSAVGKTALTVRFLTKRFIGEYSPTLESVYRYCTSTAEDDDIRLDILDTAGQVCTEWKESYALWADCFMFVYSITDYASYEEAQRLRRLVEATRRSTSLCCVVVGNKNDLVYDRQVTARQGQELAVEMGCNFYEVSACDWNQISEVCDLFLELHALWRKTRLARDGRQRKSSSSAKFKQAIQKVISGKGSISRRSSSNGNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JME8</accession>
    <name>A0ABM0JME8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras suppressor protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101857483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097111.1">
        <property type="nucleotide sequence ID" value="XM_005097054.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857483"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="108"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005097111.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30357" checksum="97BCD82F14DB12F4" modified="2025-10-08" version="1">MASKLKKLVDDVKDSSNPELDLVDKGIVNILEIPGFVNLKNLTKVVLAHNKITSVPPSIANFLNLEIIILFNNAIEELPTTLSSMPKLKTLNVGMNRLSALPRGFGACPMLEVLDVTYNNLSEHSLPGNFFCLDTLRALYMGDNDFENLPPEFGRLKNLQILVLRDNDLVALPKEMGELIRLRELHIQGNRLTVLPPEMGNLDLIGTKQIFKADGNPWVTPIADQFQVGISHVFDYIRSDTYKFLYGRHMAAGAAPPPKTNDKSKKISRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN76</accession>
    <name>A0ABM0JN76_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Manganese-transporting ATPase 13A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101861122</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097645.1">
        <property type="nucleotide sequence ID" value="XM_005097588.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861122"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1018"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1101"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1139"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="15">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="254"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="839"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005097645.1"/>
        </source>
    </evidence>
    <sequence length="1171" mass="131389" checksum="AA8625CEA9212C5D" modified="2025-10-08" version="1">MAASLNEEIHRLAFYNLRPVLLHGYVFPFLFIYSIWAYIWTVLYGIEDYFEGGLIAFAAIGLLQILTALFCLWSVHVRCALTCGKVLDPFKAQWVKVVPTPNNGSTELVKLHHRKDDGDDPLWFYFQKAKYLYDDEERKQFVPVSFPIDQSIQFYMDWRGYQKEEEALAADKKYGKNNMVMDIPKFMELFRERATAPFFVFQVFCVGLWCLDEYWYYSVFTLFMLITFEATLVQQQLRNMAEIRKMGIQPYLIQVYRNRKWIKIMTDELLPGDIVSIVRSQDDKIVPCDMLLLRGPCIVDESMLTGESVPVMKEPVENVEQDHFLNMDQDGKLHVLYGGTKVVQHTSPSKTGAGLKAGDDGCIAYVLRHSFNTSQGKLLRTILYGVKRVTANNLETFFFIMFLLVFAIIAAAYVWIKGTEDPSRNRYKLFLECTLILTSVVPPELPIELSLAVNTSLLALTKLYVYCTEPFRIPFAGKIDICCFDKTGTLTSDNLVVEGITGLNGSEIVSPTDAPLETTQVLATCHSLVQLEAELVGDPLEKATLKFVDWTLTKGETVVPQKRKTHGLKIYHRFHFQSALKRMSVIVGHTPLGSTEINYMAAVKGAPETLKSMFKSLPSLYDEVYLKMARRGARVLALGYKGLGSLSHQQLREVSREQVEKDLDFAGFVIISCPLKSDSKAAMKEIVNASHHVAMITGDNPLTACHVAKELRMTRKESTLILTPPNKLADEWHWQSIDDKTVLKAKPSNLKKELLSGFDLCLTGEALSYLQAEDKKYFLLLLANTKVFARVAPKQKELIITALKSQGYITLMCGDGTNDVGALKHADVGVALLANAPERVPDRKKKEAVDGDAGSSVDRQPANAGPANHRAMQGRPMNRAAKMRAVNRGDNLQAQQKKLQALIKEMEEEEKAQVIRLGDASVASPFTSKLSTVMSVCNIIKQGRCTLVTTLQMFKILALNALILAYSQSVLYLDGIKFSDGQATMQGLLLAGCFLFISRSKPLRTLSKERPLPTIFNVYTVLTVFLQFCVHFSCLFFLVQEAKARMPKNEDGKFIDLEKEFEPSLLNSTVYIISMSLQVSTFAVNYKGEPFMERLRDNKPLLYSLAFSTGAVLVLASGAIPELSQQFELVELPIEFRNIVLGVVVGDIAAAFAIDRVVQFLLGGGRLKTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNR2</accession>
    <name>A0ABM0JNR2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NSFL1 cofactor p47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097991.1">
        <property type="nucleotide sequence ID" value="XM_005097934.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860808"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="179"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="286"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005097991.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="39799" checksum="8C0EF055FD7D4309" modified="2025-10-08" version="1">MADREEQVDQFVNVTGVDANRARFYLESAAWDLQLAMSSFFESGDGEEADAVSAQNDVSMVTDSARDVQETSTSNRFGTLRSVNVDSDSSDEEGQAYYAGGSDRSGQQVLGPPKKKDSHKLVESLFKSAKEHGAEEKNEGDRPSQSSRSTFVGAGYRLGETSDDTTVVPGAQKPAARKQEEKKLKLWKNGFSVDNGELRDYNDPQNKQFLDSISRGEVPQELVREARGGEINLDMEDHRAEDYVKPKVSVKAFTGAGHMLGSPAPNVINAEAASGGGQAAAVKVDEGKPTTNVQLRLADGKRLVLKLNHSHKVSDIRQHIISSNPQYAQSSFCLMTTFPNKELTDESQTIEGANLLNAVIVQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNU9</accession>
    <name>A0ABM0JNU9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098058.1">
        <property type="nucleotide sequence ID" value="XM_005098001.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857794"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098058.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18805" checksum="9C11D79A30C14BAA" modified="2025-10-08" version="1">MAESQKTLLEDTTTSAQRSEKSDSDASEPQVDLQDKTEDVRKNSGVSEKAHHGNLPSDVVELCRETFQKTAEYLQGELDGTIEDYKLLEKMNSVTMNKYSEMKHIALSISGALKDLNEKYQRLHPYLQQIDLVEESVTDLERAAYSLDQYSKRLEIKFKVLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNW4</accession>
    <name>A0ABM0JNW4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101863185</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101863185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098084.2">
        <property type="nucleotide sequence ID" value="XM_005098027.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863185"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005098084.2"/>
        </source>
    </evidence>
    <sequence length="134" mass="14473" checksum="94D50DD15393CF62" modified="2025-10-08" version="1">MMEDGNAFNFWVITKSGKSIAINEATKSCSETALIWYPRFCVPSTAQKVGSFAYGPVGQTFQTDAYKFQYGTSDYLVTVTSDCTLINLVHGVSSPLGGSLTSSILTNFRASVDESAFELPSYCKESFDSSVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP01</accession>
    <name>A0ABM0JP01_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098149.1">
        <property type="nucleotide sequence ID" value="XM_005098092.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857874"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="156"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005098149.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="64585" checksum="4E911A003D17B80A" modified="2025-10-08" version="1">MASQNGQDNVPDSWDDNPNGSSDPTSDLSSGLSSLNVNAPVFTPGQNVFAQPFVPTFDHTTPQHTTSSTDGEVQSQGFTPQPNPEETPPQELEKEAMETDGIDVSPVEEGNGDIANWDEGEDEEEDIEDEEEDEDDPEAVMPVKKPKVPGQPKVRKEHLNVVFIGHVDAGKSTIGGHLLYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNLEEREKGKTVEVGRAFFESEKKHYSVLDAPGHKSFVPNMICGASQADLAILVISARRGEFETGFERGGQTREHAMLVKTAGVKHLVVLINKMDDPTVEWEEARYNECKEKLLPYLKKCGFNPKTDVYFMPCSGLTGAFLTMVPDDSVCPWFTGPSLLEYLDVMPPISRASDAAVRLPVVDRYKDMGTIVLGKIESGIVTTNQKLLMMPNKAYIKVMTIVSDEEDSEDAMPGENVKLKISGVEEEDVSPGFVLCSPEDVCNTGRIFDAQIVILEYKSIISAGYSCVLHIHSCVEEVTIKALICLIDKKTGEKSQVRPRFIKPDQAGIARLEVNGGLICLETFKDFPQMGRFTLRDEGKTIAIGKVLKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP30</accession>
    <name>A0ABM0JP30_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysosomal aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101850245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098204.3">
        <property type="nucleotide sequence ID" value="XM_005098147.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850245"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046491364" evidence="3">
        <location>
            <begin position="19"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="74"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005098204.3"/>
        </source>
    </evidence>
    <sequence length="394" mass="42602" checksum="4502224CEA01FF73" modified="2025-10-08" version="1">MRSSLFLLVAAIVALTSADKVIKIPLYRMPSARQMMRAQGVDLWALQQKYQAINTVKLDSGSPEPLTNYLDAQYYGPITIGTPGQPFNVIFDTGSSNLWVPSKHCKITDIACLLHQKYNSDASSTYKKNGTSFAIRYGTGSLTGYLSTDTVTVAGLAVKDQTFAEAITQPGVTFIAAKFDGILGMGYSEISEDGVVPVFYNMVSQKLVAQPVFSFFLDRDPAASVGGELTLGGVDDSRYTGNFTWVNVTTKGYWQFQMDGVTVGNSTYCKGGCKAIADTGTSLLAGPTEEISQLNKQIGATPINPQEYIVDCSKIPSMPNVNFELGGATFSLTPKQYVLQVSQQGVTQCLSGFSGIDLPPPRGPLWILGDVFIGPYYTQFDMGNNRVGFAQSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPW7</accession>
    <name>A0ABM0JPW7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC101861728</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098760.1">
        <property type="nucleotide sequence ID" value="XM_005098703.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098761.1">
        <property type="nucleotide sequence ID" value="XM_005098704.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098762.1">
        <property type="nucleotide sequence ID" value="XM_005098705.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861728"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005098760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005098761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005098762.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17674" checksum="F2FDB7EEFCABB02F" modified="2025-10-08" version="1">MDGQVRSEDVYGEKIDRCLYNGLVKFVGGVGVGIVFSALLFKRKPWPVTLGAGLGLGMGVASCNYEFKYGLPLSRSPELASLKVGEEMTFSSVEEVRDMGEEMSNMGEGRPCAEESEYCDSSARYVQPPCRPSPRRVEYPPYRPAGGCHMQQQCPPCGRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQL3</accession>
    <name>A0ABM0JQL3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sphingosine kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099240.1">
        <property type="nucleotide sequence ID" value="XM_005099183.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853389"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF111">
        <property type="entry name" value="CERAMIDE KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="133"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099240.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="56151" checksum="0B0817F360D7B707" modified="2025-10-08" version="1">METEGAVGSIDAEEGKGASATASDDSGDVILSGSVQAGKKSLLLALTTNGVTVHEVQAGEKVKDSSLNLDLPWCEVITAETSGEGGKSKFSIHFMQYQKDRKLRHKSLTLTSQDIEPRKWADAIQTQCQQVSGRPKNLFVIINPIGGNGKGSQMYHKSVAPMFKLAGCQTTVVETEKSKHALEIGETRDFTGFDGIISVGGDGLYQEILQGYLVQLQKAAGVNLNDIDEEFVKPKIPFCLIPAGSSNGIVRYTNDNVRDAETSALRVIRGETHPTSIITIHEPGKFIGISGLAVGVGAMTDFMKRCDELRWMGKSRYGYGMLRMFVKKKRRFRMQMEYLLDGEPSPIVKTEGAQGDTESLEIKTGWHQHDIDDKPYVGATLSTFSVKDMPECTVIDPFSCSGDLMVDTGCSNMGIIKYALMFEGKKINGPIPNIEFIKGAVGVRFKVIQDPSETDENVSQARAREREMEHYLYVDGEVVQMEGLEVEARLKNDFVSMFGCIASQLRTPQNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQS1</accession>
    <name>A0ABM0JQS1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mucin-3A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099345.1">
        <property type="nucleotide sequence ID" value="XM_005099288.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858032"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047281658" evidence="3">
        <location>
            <begin position="36"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="840"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099345.1"/>
        </source>
    </evidence>
    <sequence length="901" mass="95485" checksum="C681D274CFA2F082" modified="2025-10-08" version="1">MIKPNLAMDFGTVSMRSRAATVIVVLSVCLTVSNAKVDNTTGTNGSGVNQTPPGNNSTGIGPTLATDVQVQSEIECARVCFMNKTYSDACCMVLFKHEQQQGLYCGLNIEWRDPDTITSKDVAVHVYQQENSTTDLQAPSCSTFIVLSENQTRTMSSPANVTSQPCRLLVSAQPGQRIKMSAQLLCNQGCTTEDVLFIDNVLGFETSSTHQLSQPIAVCLGSNSSQSEHAVLLSTNDGYFLWELWLGSGSAASYNITLSAESISDPPCSECTHWTSGVSTSEAGYPCNRESRFKPVPKHDNLTNVAAETTTSTSNLTSPTDEIGNSSLTTRNIVPTHTSELPSNTKPSVGTSIATHSGIPTFQASYHLATPTLQMPSHNSKTLVDQVSYGNWVASTNPISFEKSAVTSAIISFGGSIEYSEMVSYENSVISSGPMPSLNLTLNELVASDNLVKTSVSPKNLVTSSELVSSENLVTSSKLVSSENLVTTSVSSENLVTTSISSENLVTASVSSENLVTASVSSENLVTASVSSENLVTSSELVSLENLVTSSVSSENLVTSSILVSSENLVTSSELVPSENLVTPIELLSSENWVISTETSENMVSPTELAPSDNWMTTTGLHSSDNWMTTTELHSSDNWMTTTGLHPSDNWMTTTELHSSDNWMTTTELHSSDNWMTTTEPSSHENWVTSARLILSENSATHTMMFETGNLLTVIETLSPEYSVTFTTLPSSGSLIKPSETFSPGGVVTAFELLSSRADVEPISLGTASKPLASGTEQVSKNTISRVTSSRPPAPAVTIKASSTMVQSVGETSGPPETNVSTARPHPQGYSGGGGSSATVGAVAGGSVAAVVVAGAGTAGLLVLYRRWRQMGRVAPRKQTAEETDPEIEMPMSPSPKPTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQV9</accession>
    <name>A0ABM0JQV9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">UPF0047 protein YjbQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101857119</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099428.1">
        <property type="nucleotide sequence ID" value="XM_005099371.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099429.1">
        <property type="nucleotide sequence ID" value="XM_005099372.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857119"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099429.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16516" checksum="D371F77DB275CEE0" modified="2025-10-08" version="1">MASGGEGVTVWYQREVSLSPRRRGCHYISDEILKACSGEMSKIKVGVANIHIKHTSASIILNENFDPTVLTDMEMVLNKLAPENLNYKHTMEGPDDMPAHVKAALMGSSLSVPITNGKFNLGTWQGVWLCEHRDHGGARKLVVTMNGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSM3</accession>
    <name>A0ABM0JSM3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aminomethyltransferase</fullName>
            <ecNumber evidence="10">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101846290</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005100569.1">
        <property type="nucleotide sequence ID" value="XM_005100512.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846290"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF16">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="11">
        <location>
            <begin position="32"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="12">
        <location>
            <begin position="314"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005100569.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="43716" checksum="BC5518FAC8A36D19" modified="2025-10-08" version="1">MCITNRTLLQLYRNAFSRTFSSQVESLKRTCLYDFHLSQGAKMVPFAGWEMPVQYKSGISEEHLQVRKSVGIFDVSHMLQTRVDGNDRKSYMESLVVTDIEGLKDNQGTLTVFTNEQGGILDDLIVNNIDDGHLYVVSNAGCSDQDFALMKARESEFQAAGRDVKLSPIDNALIAVQGPEVISVLQPGVDFDLTTLPFMTTTSATVFGVKGCRVTRCGYTGEDGVEISIPKTDAESIVSSLLSSSHASVRLIGLGARDSLRLEAGLCLYGNDIDQTTSPIEASLTWLVSKTRRPKADFPGASIILDQIKAKPSRRRVGFISSGVPVRGGSKIYTEDGSEVIGETTSGCPSPSLKVNVSMGYVKTPFVKNGTKVKIQVRQKMLDAQVSKMPFVPSRYYIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSU4</accession>
    <name>A0ABM0JSU4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Neutral ceramidase</fullName>
            <ecNumber evidence="2 5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101854173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="2 5"/>
    <dbReference type="RefSeq" id="XP_005100690.1">
        <property type="nucleotide sequence ID" value="XM_005100633.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854173"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046963245" description="Neutral ceramidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="531"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005100690.1"/>
        </source>
    </evidence>
    <sequence length="696" mass="76104" checksum="210E2AC38CDB4F98" modified="2025-10-08" version="1">MATLVYISLGSLLLLGNVCFGSNYYVGVGIADVTGPAADINMMGYANPGQTSHGLHMRQMSRAFIFAVSPASPRVIFVNLDAAWAGGAVKRQVVQKLKKRFGNLYTDKNVCISGTHTHSGMGGYSQYLLFDITALGFNHQTFEALVDGIVVSIVKAHDSMQPADLYVNKGELLESNINRSPTAYLNNPEAERAKYTHNVDKDMVVLKIVSSSGVDIGMISWFAVHCTSMNNTNQMISSDNKGYAAQQFENMFNPGSAPGKGPFVAAFAQSNEGDVSPNTRGPHCLDTGKECDVPTSTCNDRNELCVAFGPGKDMFESTQIIGNNQFKKAVELYNSASFKLSGPVDFRHSFADMTIQNVSLSNGSKVQTCKPSMGYSFAAGTTDGPGAFDFKQGTTTSNPFWNFVRDLIEDPSPELVKCQEPKPILLPTGEITKPYLWQPQIVDTQLLRLGQFVIIAVPGEFSTMSGRRMRDAVSSILIQGGFPANTSTVIGGLCNEYADYITTYEEYQIQRYEGASTTYGPYTLAAYIQLYRQLASAMAKGTPSPDGPTPPNLLDVQLNFVPGVIFDLAPSGEEFGSVLQDANPSYRAGSQVTVRFQSANPRNNLRTNGTFLSVERKDESGRWIIAFSDSYWETRFHWIRTETFLGYSEALIIWDIPIGQKSGTYRIQHFGTSKTVTGTLTNFVGTTSEFQVVAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSX7</accession>
    <name>A0ABM0JSX7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 12">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101849218</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 12"/>
    <dbReference type="RefSeq" id="XP_005100750.1">
        <property type="nucleotide sequence ID" value="XM_005100693.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849218"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03073">
        <property type="entry name" value="PDI_b'_ERp72_ERp57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044976074" description="Protein disulfide-isomerase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="349"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005100750.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="55655" checksum="59FE9CE88A635047" modified="2025-10-08" version="1">MYSSVVLLGLLCFCGAFADDVLVFTDANFGDEIAKYETILVKFYAPWCGHCKRLAPEYERAATTLKKQDPPVALAKVDCTVETNVCSKHGVSGYPTLKVFKNGELAKDYSGPREADGIVKYMVREAGPVSKKLESADDARNFLNKASVGVIGFFESESSSLAKAFLKVADKLSDVRFAHTISKEVKEELKQTEDGIVLFRPKVLQSKFEDAEVRCEETSSEKIQSFIQGESLGLCGERTMSNAENFQKPLFVAYFNVDYVKNPKGTNYWRNRVMKVGKKIKDEGETVYFAISGLDEMSRELEECGIEDRNGDKPVVCAWNAKNQKFKMTEEFSMDSFEQFVRDVLAGKVEAYMKSEPIPEDNDTPGKVKVVVGKNFDEIVNNEDKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDEENVVIAKMDATANDVPPNYEVRGFPTIYFAPKGNKSTPKKYEGGREVDDFVKYLSKEATDGLKSVSKDSKKKKKDKNVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTN9</accession>
    <name>A0ABM0JTN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Microsomal glutathione S-transferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005101249.2">
        <property type="nucleotide sequence ID" value="XM_005101192.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847501"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF19">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101249.2"/>
        </source>
    </evidence>
    <sequence length="141" mass="16188" checksum="8FEA76581DC30FBF" modified="2025-10-08" version="1">MSSVSVQLSSDFGYVILTAAAGWVFLQYLAWNVIKARKKYDVQYPTLYSEKSKEFNCFQRAHQHTLEVYPQFLIFLVFGGLELPKLSSVFGILFFAGRYMYAQGYYRALPVDQNRPLLGYVGFFGVYLNSIYFALKLLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUI6</accession>
    <name>A0ABM0JUI6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101859577</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101815.1">
        <property type="nucleotide sequence ID" value="XM_005101758.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859577"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="12">
        <location>
            <begin position="377"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005101815.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54201" checksum="2F1D23A87F1861CF" modified="2025-10-08" version="1">MANTGDCCAIIMAAGSGSRMTDLTNQCPKALLPVGRFPMIWYPIRSLEKAGFSDIVIITRKSWEKQMHSILSDKSVPILARLEIVSIPDSEDLGTADSLRRVAPKVKTTALVVSCDLISDCDLTDFMSVHRKHNSSITVMLSQLPTSIVAETLVPGFKSKQKNAASEKISIGFESNNEDHILFWRSQIDMDSEYLSLSKRFLDRFPCTRIQSKWTDCHVYMINKFVIEYLINRSDINSLQGELLPQVVKKQMSTLVKDKSHEEADMTTTEEADMTSADADNKPEKRKDLIDYVAGCEFDLTREANFLSLTSSNFGASPDSPQKDLIRCYAYRQTAGFCVRANTIAAYFEACKQIPRLMLQFLDNKSKGTMPPVPESTSIKPKSQVGADCLLGENVEIGEKVSIKKSVIGRHCKIDDKVKITNSIIMDHVTILESSNISNCIICDSAKIGDKCELNSCIVGQKQSISTMSKHANEALSSVTQMMEVALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVF1</accession>
    <name>A0ABM0JVF1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101847437</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="RefSeq" id="XP_005102459.1">
        <property type="nucleotide sequence ID" value="XM_005102402.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847437"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16705">
        <property type="entry name" value="RING-HC_dBre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058642">
        <property type="entry name" value="BRE1A/B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26052">
        <property type="entry name" value="BRE1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="945"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="173"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="531"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="241"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="173"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="535"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005102459.1"/>
        </source>
    </evidence>
    <sequence length="998" mass="115230" checksum="70B525612DC4DBAC" modified="2025-10-08" version="1">MSKRPAEDSASSSGAPAAKKMAVPYDSLQLGKIYSLEELDLKVLVFQNKKLAERIEQRKKAETELRKRIEQLENRQRTDDAVLMIVNRYWNQLDEDVRVLLQRFDAETSDETETKNESSELTSFLTLLSTWDKQELEEKLGQRVEFSKRAIGKLLQAFDRMLQRNEKLHHAMEDKVEQEKESLLEETPKPEEESKEEEKKEEESEEKTSKPEEESSEEKKEEEATESVPEPSLKDVVKGELADLRQETKQLHNLVTQLHQRHHENTLQLSELQDKLTASETEIAELKNKVDDLEYMYEKSENKCDSTERRLQEVTEKLQFYQETTGNLPISGLKNVPGVPTGRLDEILSELEEHKELSANRLMELEKLSGDYQETLTEVEKLKMDLQHLPENVILETTEYKCLQSQFSVLYNESMQIRTQLEEIRNQMTINKNLHSRQIEQMEQYEVEGQKQLKMEVIQVEDSLTQTRKEYDMVRIEFEQAMAANDQNLTINREMRNLIQSLQNHNQQLKMESARYKRRLREAQVEIHKLKQELTANNPPSSSAPNSGSAATTTTATTASSSSTSTTASSASPPAGGDSKEGVVQVKEEPQSSPVKTEPAQGGVATTCPSTPVVKKEEGEIPTTPVKKEEEEEGECKDSRNGKNDQELIKDLRNQLKKSQDNVRELKLLLDTYKAAPKEQRDRIQLMSAEKKARQEVEELKGLMKRMQENERRERRKLADDDAMRKIKKMEDTINELQKNLANQKQREEALLNDLDVTGQAFEDMQEQNTRLLQQLREKDDANFKLMSERIKSNQIQKLLREEKDVLSQNVATLQSQVDAQNTVVRSLEEKERILQNNLAIVEKEQGLTQQAMEMHKRKAVESSQTAADLKLHLDKYQAQLKEAQVAVAEKTASLEQEVFKYKRMQEEVAKLNRKLERSKKIEMAGAADEVLLEEIKEYKEQLTCPSCKVNKKDAVLTKCFHVFCLECLRTRYETRQRKCPKCNAGFGANDFHRLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVN7</accession>
    <name>A0ABM0JVN7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterogeneous nuclear ribonucleoprotein A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101863683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102616.1">
        <property type="nucleotide sequence ID" value="XM_005102559.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863683"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF14">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="37"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="127"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005102616.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="32963" checksum="529581787ED72F49" modified="2025-10-08" version="1">MPGFQQRVMGGPMGYNRGPGRYGGGDGESEPDPEQFHKLFIGGLSFETTEASLKEYFSKWGEIKDCIVMRDPQSKRSRGFGFIKYKLKESVDDVQKDRPHKIDDRDVETKRAMPRDDPCLTSQQSVKKMFVGGLKEDTKEDMIRDVFAEFGEIELIELITDKGTGKTKGFCFVTFNDYDPVDKLVLKKRISLNNKMVELKKAFAKGEGDPRMGGGRVGMGGMGMPMGRGGRGDYGYGHGFPGGYGGYGPGYGGGYGPGWQGGYNDFPSYGHHHHQGNQRGYGGNNYGAGNNYGGGFNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVS9</accession>
    <name>A0ABM0JVS9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PiggyBac transposable element-derived protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102686.2">
        <property type="nucleotide sequence ID" value="XM_005102629.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858792"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="158"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005102686.2"/>
        </source>
    </evidence>
    <sequence length="626" mass="72236" checksum="4A0C17CDF391B5C5" modified="2025-10-08" version="1">MATLKSVQMEKQQLGQQAAQAVRKIERHSLHSMLREKKLSAQHKKVTNRLNILLKKAKSEISCLRRKLSFTAERVNNADKLSALRKTLASTKAAKTRAETEIAYLEERLKNPAKIDCHCHVPDIDVFMRCKKTTGYLILSSKLVRGINPDIDTRGMVPLDFFRLYFTDEIVEELCKNINDYGNQRCEARAATATERSVYKKWRKITPGELFKFFAVIIAMGITKKPSVSDYWNTDLSHMATPWFRQIFRRDRFQHIFHTMLHACELDAQGKAKIEPFVSSLLVQFQAAYYPTQELSLDEMVIGWKGRWAHKQYNATKPSKYHVKTFGLCESESGYVINLRIYFGAQTSFDPMTADAQQSVRVFETLLSPLVKGHHIYADRYYTSMQLLNHLREKQFYFTGTVNANRKGFPAELKTAKLAHREIQWYLHREKQLLCVLFRDKKAKKSCAAVSNSSSVATVTVKDVEKPSMINAYNFNMNGCDRVDQAVQTYGMYTRKSTKWWKKIFFWIFEVSQVNAHILHMKAEGRKTPLLKFKHDLISEMCSHTAALLLEDIEQQQPDDRGHIPSNNPVAGMKSNHFAVKSSLTRVCRHCNTPTNRKRTSFYCKGCPNQPFLHPTPCFEAYHLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW24</accession>
    <name>A0ABM0JW24_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101860668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102861.1">
        <property type="nucleotide sequence ID" value="XM_005102804.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860668"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1375"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1471"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1736"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1769"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1817"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1996"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2312"/>
            <end position="2341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2379"/>
            <end position="2414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2704"/>
            <end position="2794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2802"/>
            <end position="2821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2908"/>
            <end position="3057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1429"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1769"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1783"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1817"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2312"/>
            <end position="2322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2392"/>
            <end position="2402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2403"/>
            <end position="2414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2704"/>
            <end position="2723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2737"/>
            <end position="2747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2755"/>
            <end position="2772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2908"/>
            <end position="2936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2946"/>
            <end position="2964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2966"/>
            <end position="2981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3023"/>
            <end position="3035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102861.1"/>
        </source>
    </evidence>
    <sequence length="3057" mass="338410" checksum="8A68D7B0A11F3A1D" modified="2025-10-08" version="1">MSKDSILPSETQNDIGDIRSCRQLGEHYHDTNSERSSAESDPYPIWENSSFNEKMNRVKNSRAGLGQRTLPSNRGRKGGTGVAVSTASLATKEGRVTSKHKEQAHTATVPSLAAEQDSKHMQSLSNRLRESQKSFLTDSERREWYEKRGYTISANGLIVPRHQPVAKSENEESFIENYNEKEKASCDVLCSSPGGDKQRRKNCDCYLSSSDEGSGKGNFSDKDIPCIPNMKKFMNRRKRFIRSSPREQTTFKALGCPATNNEESGSSFLDNKDSGNRHLLISPDMFTRLYPARVALDFLSSDFHCGNELLDMECYGSYEDGENHVFEAATADEDIVDLHECGDVSGSNRYSQMGKSVNVDVQNDQVKSKKEIHSTTDDPKHEIKRTAAALSGQGDVINQANQAEGHESRYSGASLSDSSQSESSTEDEEEIPGDSDYVKEKTQEDTRHTGRLSPNSMVRTCYANLMCSMLRQNSVLLDNADMEVYRQSHSYECTEPDSEIDMVIPTEPKSIASSPSDNLQDMEPVIEVRLMKQKLTEPPSFSDKTQFETGVKIEKSTEEDSACSKQKMSRSVKTSDQEEFNVSSKDENKQEHRTGDKLPLVTKQYSNCHQTNQAGSTKVDKWGSNDSRVSGLIHGKDANEHDSMDATVQSLPSKSDEDVPGDLSLLITTESKDTENLGEVETDITTKIRVSPMGIGNSSGGGENRYSPLHSCRGQNSSNLEHRNNKPRVSNAKKENTKETPSRSTVKTPPKDMGSNVSKSSPSPRLPVYPMTISDHNLYCRQKHHYDYEVEVNSPLRQICKVSSNDSLNCSQIVTDSCQNPPKMSTEKPQEIHSRSNTTHLTADNSGRVSGETIKSDARLLREQQAITNGQIETSLALTQLYNKAASRAVTEILGSPPVPRPSIRQSPCTYHETSEVPLNCERRNNGQALTAEREHLEYSSDDNNSPTPIPLDDPPQYSTEHGQIIKSHNENNFRSCKESFEKELKNDRNGDCVQYKYESKDSENDSCSNGDNHNYSNCDRKSKNKYTDKTKSPHSCATPVWCDEKHEKETKEHRTHFDSNMGSIERKRVDVGESVNMPYIHGYKENIEEFNQQGDHTISSPHQSSCCLKKELIENSGSPAQERQLFSDQSLLRPNSDEQFLPLDTPLCTNQTVPDNTPNASKCGSACSLSESPDQRQQGTSDIAGVSPRESQSKSSEEGVAIGHLLELPSKQNQGKEEDSDHWDRIRAKFELFQERKNLQSYTNGGSFKTASRSLRQSINSRIETLNKMLVSTTRSERAGVVGNPRRTKQSTNMTKNLSSQSSSTSKIPYNSRQGSHHKGKDGFVLSSDAQGAQITEHVTEKDFTPNVPFDSCITVTKIPVRAKGRPSLQEAVQANAYSNKQQKDTSKKKYFSKGERQPLTCPEFQPRKRYSAEENTRTKFSSEESMNKSNNASGDSCTNNVRDTNLVPNDSFTQDIFLGSPRDLQLAVTSPKEDTGDTEGGASANNINQNSHKGDDVCVGLVKHGSSICSENDSPSIGTLQTDLKFECADICARCLETELHVSAMGVSPVLHCLFEQNANLKKSNLLVLNKTEGYPDGSCAPSHLFDVASTKMYNIQASTTSLTPEQILEVPVSVIKSEPPGGNYEHQRKEITSVLPRKLARFMDAKQPKQAGLCIMAKQTKNQDKMTIENTKTGARNLYENISGEFGFKKTSRKNYKTLVAEARAGIEQILSRNDSRSETSRAIKSDKTLPSQYSNISETTPRYGSDRSTQCVQTDYVKNKSAKYTTTAGQATTPTSRTSPQQLQQDSTSDSNKTPDETQYFKNLLTEKQVLQDENGNNSKGSGTSLAHSKCTGLRSHGNKSDLLSKAATPSPIGNGGQAEEKKIKPNKIRSLKETLKTAKNCRIPIRKFQSQSSTNPSTQCEYIQLNNIQSIVIASTVDRQNRRTRELAQISFKSCKMKNERLNNCLMTASNNINIVNTDGVLTLEISAQSDSVAAEGEGECASNRHKYKKTAVSGHHSPQTESKSKQHSKLPCVSFGKGSKVLSQGVASNTKIPRCQTAKKSRETMKKDIKECKKCESEAESGGREHYGAKEILHKTTVSSNKENTVSSDKIADQTKDNVKKIAYARQSVPITASAKLPCKQGLGRSPAKEKDALVGLVTSTAVKLPASEKGSRLETDCSTKTESLLARCELFSASTPSEGHRFSEAESLQEYVELEDCLVKYQRDPCESCFSQKEVYQSCESRISHSPVRVDDQTQQVEDNVNQKKIIIPVHASAGSEFPTCQNQADNCEVRVREESRKEDSQTERKPAVISVVSDNDISQDLANRHSVQSSQATQDEAFEPGTSTSTFSPGEELSRTDHLKFPIDQVVSVHTTANVCFESQTYNTSKISTDEFSGGSGLDETQEDIPSSLPNVTQVGSCGSVGSSSSSLPDQQFLDLIHKRAISKSNGELTDPESIHEDDDHRRILSNCRFGFVPSDAHKNHESKIPLKREKKTCLKSCLKSTYSLEEFPKHSQELDDDNVCLLNSTDKQPERHYMGECAKSTEEGTDYKKNETCLRNTLSGKAFKNFEKDGYSEIESMHDFGEHSNALENMENAESRVDDVMVAAPETNEENIMALKTNITVNSLGIKLCHRACDQDNNMTLPPTTGVVAECHSHFCPKMSAVSPNIPETLPDKRKPPTKLAEKFTLTSDESSDSFAVLEVHEDVKKTVNNDHVTTPVTQINDHSVIDQQPSASAVSERAATGVEHQKGNSPALSTQHNTNKRECIPSQSSNHSSMETPSSSNGLRDEKNPGATSPSTPKAVIYSSAEIPELGEKLFRRTPGPRRLTNNPQKGRLTMTLINRGASARHQTPTNSQKQGTLAGTKGRMITALPATESAEQQHSDCYAPESLKEESACMENGNISTEVRDRCYVEHNFKSISYSTSDDEGTNQILSSRSQNKVDTYTNSSDENKKISRDVASSESNHTRNSNIGSSPKTIYDETPTRKPPNEHDCINNSTHKVATTPAFAQDKTQNNRHKIGSKSRIPLVKVKDARLSTTKAENVNKTESLPPLSKRQNGLPHKPKMKRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JX97</accession>
    <name>A0ABM0JX97_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptor GRL101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101859425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103708.2">
        <property type="nucleotide sequence ID" value="XM_005103651.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859425"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF8">
        <property type="entry name" value="LD11117P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045270827" evidence="9">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005103708.2"/>
        </source>
    </evidence>
    <sequence length="128" mass="14346" checksum="A4EAF686440AE007" modified="2025-10-08" version="1">MLRSIWILYLFGMFFIEVSFSDNQVVTYEVYSPKDSAPTHVDCQATESAFPCDDVKQQCIAREKVCDAVWDCEGGKDETVEVCGCLPHEFQCNASVCIDAVRRCDRLDDCEDGSDEDNCGKSFLTSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXX0</accession>
    <name>A0ABM0JXX0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860910</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104137.1">
        <property type="nucleotide sequence ID" value="XM_005104080.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860910"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104137.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="65545" checksum="27A4B84F4B9E0D64" modified="2025-10-08" version="1">MKRPTSTDAVTSPNVPVAPSSLDPMSTTTHGGTQGPGPTSEGDTGGSDSSSTVVILVVVLLALFVVALILGIFIFRRRKDLKETKFGGIRSMLSSWFRHVTCRGRRSSEGDIYDNDLTFPRLPEEPVSNTRLSIIPRANFVCLGESQPPQQDTYSTDNALDNRRSGVFHDSEEVYDDALIYNPYDIVYDNVIRDEGVNSVTGDTKSRKPSKLSGDSSSPAKSLPSPEKIIEEKDQQNSNPTASPVIYEKKQLRPTSGTAADSCHDETGVTVKPGDGEERLTIKNDLYQFHQEMLDEELTRIRMDKSRKFHSSPADHSPKPQREPDTNSSTILRQPKDVESGTALGSRHPKDTQPETAPVRGRETTEHRVQDSSKTSSIDNANDPSKHEHSIKIRKKKRQPKDNSSHDSHTQSVKPNKSSKQQPHHQEQAHLSQEEQQFFHELGISTDATEQPESMSLRDKKESSNHSFESKAPTSKKEIDSQAKSVHVEEPRLTKSTNSIKDGHTESSPVARKLLHGTKRESDSRPKKGASHSAPAKSDNKTGKKPAKPELVSNIIQMSLDGIKEKRRAESPNVNSEISDDKAEAIGNESSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY76</accession>
    <name>A0ABM0JY76_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="9">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC101852342</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005104358.1">
        <property type="nucleotide sequence ID" value="XM_005104301.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827193.1">
        <property type="nucleotide sequence ID" value="XM_035971300.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852342"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="66"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005104358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035827193.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="41546" checksum="4FF9AF54CEB21C10" modified="2025-10-08" version="1">MSSNEEPGSSKDKVENDKSVGAEAPEGAAKQDDGTDDNPAEKDSMDMFSLSEYLARSLGLREKPESRLVEISLAGIAKFLASEECKNVVTMAGAGISTSAGIPDFRSPGTGLYDNLASYNLPHPQAIFDISFFRENPKPFFVLAKALYPGSFKPTPAHYFIKLLSDKGKLLRHFTQNIDTLERVAGLDGDKIVEAHGTFYSNHCQECGLEFSLEWMKEQIFADVIPTCSEEGCLGVVKPDIVFFGETLPKRFAECVGQDFNKCDLLVIMGTSLQVQPFASLVNRVPFSTPRLYINLEKGSSSCNPISALLFGGGFQFDSEDNYRDVFKEATCDAGCQELADLLGWGDELKTLVASEHKRIDAAQAKQPPANTSQKKSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYM4</accession>
    <name>A0ABM0JYM4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101852109</name>
        <name evidence="6" type="synonym">LSM1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved with other LSm subunits in the general process of degradation of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104619.1">
        <property type="nucleotide sequence ID" value="XM_005104562.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852109"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005104619.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15091" checksum="4CE8A1D2E233D7CA" modified="2025-10-08" version="1">MNYLPGTASLIEEIDKKLLVVLRDGRTLIGYLRTIDQFANLVLHRTIERIHVGKKYGDIPRGIFIVRGENVVLLGEVDLENENNLPLEQVDIDTILELQRAQQMEREAEQERKKKAMAERGIHIDQAIDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0J4</accession>
    <name>A0ABM0K0J4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101851434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105912.1">
        <property type="nucleotide sequence ID" value="XM_005105855.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851434"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005105912.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43426" checksum="59FF34250439A2BB" modified="2025-10-08" version="1">MTSFQKKARIKVGQIAGTRPSLYSNQLLVSTGIPSLDNVIGGGLAVGTVMLVEEDIFGSYARLMLKYFTAEAIVSDQTVLLASRQESPEQLVQELPAPIEMGLRSGPAGASAISPSPKAIASGAKKKPDGPDEEKMKIAWRYQSQPKVQSTPTSGVQFGHYYDLTKVMDQNTVEAAQLFYASSQDIPLESSSGALRNKSYCRLLQDVHQRIQEGCFGTGQKTAKRSILRLGIHNLGSPLWGENGGLNPSGDGHDPSLTQFFLALRAMLRSALAVAMVTVPTHLFHDKGYKRRLERMADTVIRLESFAGSPKEKNPAFKEYHGLLHLVQLPRLNSLIPAQPETTDLAFKLRRKKFTIEKLHLPPELADTTGRSQDDDNPLTSKVMIGCSSSESSKLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K138</accession>
    <name>A0ABM0K138_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase MYLIP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106283.1">
        <property type="nucleotide sequence ID" value="XM_005106226.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858962"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FERM" evidence="4">
        <location>
            <begin position="2"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005106283.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="56320" checksum="8ABEAC8BC5A01CCA" modified="2025-10-08" version="1">MFTCYITLPNKQFHEIEFDPKQIGQVILDKVLDVLGIIEVDFFGLQYNGSKKEELWLNLRNRVCDQIIGSSHVYRLKLRVKFFVEPQYIQQESTKDLFYVQAKEAISKGHISLTEPHCDECKLAKLVAYITQAEHGDLTCNSYQRHTYEEILKELYPTYIPSQTLIDRVLWEHSNLHGMPRASSRYFMLQIVSELPGYGMEVHKVHTAQGFDVNFGVGPEGLVLQNAKTKEERTIPYLQISLATHNDKSVHVQLIDEAGEPQIEECYKLVSRKAAIALYRCITEMHSFYRCDTVCPDVQSQYCRDFKGTFVSIFNENSELGKRYIFDIQRTSREAYDCVRRKLYAKSSSPNCSPVHNFHSCGSCVDEDEEEEDEDVERNEEEKESVVNDVAGDLIQQKQNTNLQKEVKSLKRRLEVLEDSLLCCICMYQKVCMVLCPCGHMTCDMCCERIEECPLCRTDIDRFQKVFQGFGSNANTVCDSIPHVQTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K158</accession>
    <name>A0ABM0K158_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101851823</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106334.1">
        <property type="nucleotide sequence ID" value="XM_005106277.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851823"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029774">
        <property type="entry name" value="CSAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31022">
        <property type="entry name" value="CENTRIOLE, CILIA AND SPINDLE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31022:SF4">
        <property type="entry name" value="CENTRIOLE, CILIA AND SPINDLE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15748">
        <property type="entry name" value="CCSAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106334.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47251" checksum="D7CF28579BE4E8D5" modified="2025-10-08" version="1">MVAKKSEYQNQFRSSVVRKHQAIYLENLNLRHQRRDREFVHTPICWGELSDETDHTTSDSNEDDKPRTAPEEKHTEAEPQYQSIAEILADSRQKADAFKHKRSSEKTVVQTEIPSFEKLSLDCKEGDLQEKKLSRTAEENLKGHKKDIGDKSLSIYDIVDDENRKLNEKLTKTYALSKGKIIADITDESDTEGDEKVQAEIENDSNLRKRTFVKKRSRGSRVVHKGKAADCPRTSFESRSKAQPSRSSDYSSKHESPVPPLPLPARIRRPDRQARIPSAKSRPKSAASSVGERPPFITYGAGDMEDNLALHRTHNVRAPANVYGAALKAKIRREEERRKYRERKELAKNKAALMDKLSSVSPREQLDLRSEYQKQFQAYEPKEYERAVSARAVIPRSSPIRAVHRGGCLVVHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1G4</accession>
    <name>A0ABM0K1G4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major royal jelly protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101856530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106530.1">
        <property type="nucleotide sequence ID" value="XM_005106473.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856530"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045115675" evidence="4">
        <location>
            <begin position="26"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005106530.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="48810" checksum="76AEB5D8058BC79C" modified="2025-10-08" version="1">MTTLRRSFLSLWALCLAITLIPSHAEVIHEFVTIDYEWPNSTARAQSLANGDYAPKTGVVSGIQVYKGSYHYLSFFGEHDVPYTTIFVTVPRTQAVKGIPSGLNTVVKDANGKSVLRPYPNWAAQKIGDCSALQLPMSMAIDPNTGYLYVIDIGRVGISSPNPANLCPAKLVVYDTVGGGSTILSYEFPDSVVSRTTNYLNDIVIDYVNPEGTGGVKYAYMTDTLTRSLVVYDFAHNKSWAYKDPVSMGTDDDVDITIHGIRYRMDVGINGIAMSPTFNYLYYSSVGSKKLYQVPTWVLRTPGNDFVSNTRLVGSKKSQGGGMVFGHKGLFFGALEYDAVYRWDIEADIKSQRVLEGEVVMKTQVPVAQNWQTMQWTDALSLDNESNLYFTTNRLQKFVTNKMDFDGGEGANFRIFKYNVHDKSYLSPPSPFDGPEVVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K229</accession>
    <name>A0ABM0K229_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-related protein Rab-1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101847446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106931.1">
        <property type="nucleotide sequence ID" value="XM_005106874.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847446"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005106931.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22830" checksum="58B1E62D419016EE" modified="2025-10-08" version="1">MSTMNPDYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKSDLTTKKVVDFTTAKEYADQLGIPFLETSAKNATNVEQAFMTMAAEIKNRMGPVTTASDNKPSVKINSSTPVNANKGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2K3</accession>
    <name>A0ABM0K2K3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101851217 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107280.1">
        <property type="nucleotide sequence ID" value="XM_005107223.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851217"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055309">
        <property type="entry name" value="Znf318-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15577">
        <property type="entry name" value="ZINC FINGER CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15577:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN 318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1360"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K380</accession>
    <name>A0ABM0K380_APLCA</name>
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            <fullName evidence="6">Uncharacterized protein LOC101855593</fullName>
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        <name evidence="6" type="primary">LOC101855593</name>
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        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107727.1"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134052" checksum="EA22C40BE3A415ED" modified="2025-10-08" version="1">MLSSFTNMAASVGTEDRTRDHSSAVMASPPATSATSSSNLPTNINELLWEEKKRTLRELISSYRLPLAVKLKSGDVSKFLGGSNSTADRTGNSETSAGSQNSPSLGNGVSVGRDSNPGTPDSKDSCLGRGGQEEVILQIHETRRRKIILARKMTWEKRQNDYVVTGEQVEIPASFKGWLEVVPDDGRPVEYFDTVGGITSVKPRRFLVRTSTVGYQLSTEENGTSCWMPSEIRPGEVLTTGIIYMDNKKTKNATQRNIFKRFLKQNKVKKEQDLKYLQCFDADGREIMIPLIMSGVFSPVGDATMANYDAVFELQDLIMAFGLPVNAQLIHTNSKETFPCPRGVLRLYGTREEELAIVSRVGSSGALFSDTASCDKFEIPVDKDLAFSRGVVKKKPAIKAKLGEVFHSPWSKDKSGGVGSGVGGSAKVSDRESKDKDYVRATTVDEFKPRVNPDRRFSTPVSNKPAPVMASYGSHAHPAASPDTYREPHKTRASQVINSVPVLPPRESGTSSTYSTGSANTTIDTSVVSASVEEHQKSLEKTPDKEQKPNTEIGLPERSKELKKSKSTGILDKLSVRKVRKERAKLKALRGEDVFSKKIVRNDLSYQDFFNGLDGEEEEGASKENERSSTSKQDDSGRGSSSSTYQSNPSSPKSSVYEGGSEGQRSTGSERSKGSDYSSLVQRRQSIQNRDLPPIPPESPRGHENSSPYHHNESKESLYEHLPPAPQPPSSRRASESMAPLGMMTHPDDHEEDDEEDGYMVPMQVQREQRERERYSKRSDVVLRQKPPSSAGHESLRYSRARKARSELPSEFAHRMRDQDDGCPLDIDDLFSFAYNSKEFGENRPLGSLGSQQAISTSQLYGPGASRVPAWTSDLPPSVSTHFDQRFVDNLDLEARGHQQGLRYRSKQARNMNANPNATIRSHNLRKMRPSMMEVFHFSDSFRDIRHGDSGTEHIIGPPVDFQNSYNPHQNPYDHPQQPPPPPPLQQQQQHYYPAQNSRPPLLNSRSMDANVMTPLLPHHHHHLQQQQQQQQQQQSIYGPGGYGMHYAESEPCFRPSHHHPHHPHHQHHNPRSMGGVMSDNLVQHGDDSAISMCSRGEGGFPNESEYSYSEYTEEPPRDVTEDGWSPPDNVEGLSVQEVSKSLRYIGMKDRVVLRFSNEQIDGNMLCTLDKKLLKEGFPELNALELKKILDFVQGWRPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3I3</accession>
    <name>A0ABM0K3I3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101860362</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107916.1">
        <property type="nucleotide sequence ID" value="XM_005107859.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860362"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="14">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1899" evidence="14">
        <location>
            <begin position="505"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="629"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="672"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="406"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="887"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="937"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005107916.1"/>
        </source>
    </evidence>
    <sequence length="963" mass="106444" checksum="BA4CE1A42D80D310" modified="2025-10-08" version="1">MAWRFKVSKYKNAAPKFLRKEENILDIPVSDVAQSCGNHIKSSCVYFAFNIDSGGGGNLGFLPLSASGRQGGSLPILQAHGDVVTDFDFSPFDDYLLATGAQDNKVKLWLLPEEESIENVSEAVLSLPAYERRVENVLWNPCADGVLAVTTDKSVKIYDISGSGGSEIFSFSDHGDQVQGVSWHGDGGLLVTTCKDKKIRVIDPRSNSVVQEGAGHPNVKDSRVLWLAGKEFILSTGFSQTRSRQFRIWDPRNLSSSLMSTDIDTSTGTIMPLYDADTNMTFLIGKGDNSLNFLEFTEKDPYLSSAGVDRTEQIKGAALVPKRAMNLMDGEVNRVLLLCKNSVIPAPYIVPRKSYRDFHSDLYPDTRDGLPAQTSDQWAQGQAAQPNFIKLEPCKHLVHRDRRGALLKGSNSGTAVSSSAVKPQATESARNDSVTQPSKPPPAVSSPPPAPEQPSNTSQSNSSPSPKPQPQKPQQQPKQEPIPAKPEKPAEKPALPPKKPAKPFAGVRQSKFRHIQGHQQHASGSITNVRSVCKTVPGESDMFAANVKRCAVPVDGAGGCLYVFELSEGARQPDTGVPVIQNGSKVTDCAWDPFDDSRLVVVLDNAKINVWRIPDGGLTESTDEPEFSLRGHMEKIYFVKFHPLASDLIITAAYDMTLRMWDLKEQKEVMLIEGHDDQVFCLDWSSDGKQFATVSKDGKVRVFEPRKSTSALREGPGPVGSRGARIVWALNDKFLVVTGFDRTSLQQVYIYRASELKVLHSVDVNVSPAILMPFYDRDSSVVFLTCRGDRMIYTLEVAEDAPHLFECAPFKFDSLHQSASYLPKYTCDVRKVEVMRGWRLTSNSVDGFTFTVPRVKMEYFQDDLFPNTDVTWEPTITAADWLAGKDKRQKTKSLRPSDMKPLSEAPVEAPKAKKFESYNAETYKTDEQRKEELVSAMAGKLEMSDAPLPQDLAEGVDDDEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3J9</accession>
    <name>A0ABM0K3J9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101846990</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005107942.1">
        <property type="nucleotide sequence ID" value="XM_005107885.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846990"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="400"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005107942.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="49292" checksum="8D57DB065C2E4700" modified="2025-10-08" version="1">MSSGETAVTVIAASAERKTFSNPKARGRRTAHQIPEEILNDVEINAAIKQLPENYNFEIHKTIWKVRQTGAQRVALQFPEGLLLFSCVIADIIEQFTEAETVIMGDVTYGACCVDDFTAKALGADLMVHYGHSCLIPIDQTEGIQMLYIFVDIKIDMMHFMDTIKFNFDAGTRLALVSTIQFVAALQSARQELNKEYVVSTPQCKPLSPGEILGCTSPRLSDTDAIIYLGDGRFHLESIMIHNPLVPAYRYDPYSKLFTREHYDFDRMKQVRQDAISKAQSAKKVGIILGTLGRQGSTKVMENLRAEITASGRDHVTILLSEIFPDKLKLMSDVDAWVQIACPRLSIDWGAAFSKPLLSPYEMSVALQLAQWQDTYPMDYYANESLGSWTVNNEVNKPPRQRKARVKIATDPSSSSSDKLCSLSSSCCQSTVEKSCDTEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4W4</accession>
    <name>A0ABM0K4W4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endoribonuclease LACTB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108821.1">
        <property type="nucleotide sequence ID" value="XM_005108764.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853646"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005108821.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32426" checksum="F9BD60F8576CAEAB" modified="2025-10-08" version="1">MAAEVLPKYLQLSQRVIRILGCNPGPATLQGTNTYLVGTGKRRILVDTGEVDNKEYLDLVKSSLEQQNVELQEIILTHWHHDHVGGVDGICRLFGQKFRTSKLKRLSMADMKLSETSYTFISDKQVFKTEGATLQVHHGPGHSEDHIVLKLEEEEAVFSGDTILGGSTAVIEDLQEYMKTLHQLLDLDPKVIYPGHGPVVAKPKEVLAYYIKHRHDREQQIVQYLKDNRGKPSTAMDIVKVVYKGVPENVHLMAANNVTLHLKKLQKENVTVSEDDKIWRLASESRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4Z5</accession>
    <name>A0ABM0K4Z5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Cyclin-dependent kinase 11B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101849244</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108888.1">
        <property type="nucleotide sequence ID" value="XM_005108831.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108889.1">
        <property type="nucleotide sequence ID" value="XM_005108832.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849244"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005108888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108889.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="56112" checksum="A017D639782AB5A2" modified="2025-10-08" version="1">MEGTTLNKKMTPLHRRFSCPDGKLAFSNAHSEESGLKKRTFNREETVLSETFDLNLDFRTTKLSTDLITKDRNENVKPGGESLNGRRREKTFINCSSILENPHTDRGTYDNGKSKRDIYMRERPKTSVGVGRASYLAQKRYSLPIIHQTSDDGLTRDLTRRTGPRLSAPGLMVKSAGGGKKENFLNTRRSSHDSVDRELKCLYQNNLAERRLSSHVKELERQSYAGRLEQRQQRRELYQQYRAMVKRTPSADQWLNQRKSQTSILKNREHEEIARRYHRILRIHKAPAHLQDMVARVRNYVMLQAGVYRNLMEEEEPDEYAKQDVSPTEEEDELGEEEAEEEEDGVENFDKLALQSFIRRHTVTGDAILRNLPEAQGYSEEAPLSRLRRRMSTCDIKHIKGILDCRDGAVSAAATVDDVCYQQGEGQGKEETVSEEEEDNEEEEEKEEEEKEEEEGEGVEEEYDNEEEYEEEEEREATFQTNGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5U1</accession>
    <name>A0ABM0K5U1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-structural maintenance of chromosomes element 3 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109416.1">
        <property type="nucleotide sequence ID" value="XM_005109359.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853499"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="43"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109416.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29934" checksum="74019688484FB0EF" modified="2025-10-08" version="1">MPRQSQISSSQASQRAGNSSQLSQVPSSQNQSRASREMDPVEVEKKVNELVQFLLVKDQKKIPVKKSEINKQILKESSRSFPEFMRQASEKLSEVFGFQVVELQDKLKGSYVLVNKLNNKASSPHISWSPEDEAKMALLAMILSTIFMNGNIITEEDLWHALKKIGIRSDEKHGTFGNVKSMIMEEFVRQGYLELVPQPNTDPQVKDIAWGQRAKHEFSKRDALNFVSQIYDTEPTAWLHQWQQVQAEAEAQNQDQPSTSAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5U2</accession>
    <name>A0ABM0K5U2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101853735</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109417.2">
        <property type="nucleotide sequence ID" value="XM_005109360.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853735"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="14">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="13">
        <location>
            <begin position="147"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="15">
        <location>
            <begin position="286"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="12">
        <location>
            <begin position="484"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005109417.2"/>
        </source>
    </evidence>
    <sequence length="673" mass="75194" checksum="4F9B95A7B8E62412" modified="2025-10-08" version="1">MAAAFNIDISTIPVNKDLVKERATASFKVAELTHIIDGGPEKTKRRKELESIVLSDPLFLNKNGVNLTKSEAYENALQKSVKLKSWRRQYNWSEEDYEIITNRINCFDEALTLHHTMFIPALERLCNEEQKARWLPLALNYRIIGTYAQTELGHGTNLMRLETTATFDPETDEFVMNSPQISSMKWWPGGLGKSSTHAIVLAQLYVRDKHHGLQAFIVPLRSLEDHKPLPGITVGDIGPKMALANVDNGFLIMDKYRIPRDNMLMGNAVVTREGKFQMLRADKSNYSTMMYVRVQIVQWSAFTLLPGTVMAVRYSAARRQSSLKPGGEEVQILDYQTQQYKLFPALAAAHATSFAAQTLRREYDAALGDLLKGNKQVMGEFHSQTSVMKALCSDIAVEHAEILRRSCGGHGYMLLSGLAPLYTSSLGLVTVEGENTVLYQQTARYLMRQMAATLSGLTVGHSCSYLADPQETELSITSPEQLRDLDLLLTLFKRAAQRIVSQTAQRLQADMERGLPQDQAWNKNMVALVRAAKAHGWQTLVQYNVRAVQGLRGSTSPELATVLHRLCCLFALHAIETNAGNFLETEVLNPGELGLVREVEMGLLGEIRPDAVALVDAVDYPDSSLQSALGAYDGNVYERMYKTALTEPMNRTDVHPSYYKHLRGFIKGTSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5Y5</accession>
    <name>A0ABM0K5Y5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cullin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101855828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109508.1">
        <property type="nucleotide sequence ID" value="XM_005109451.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855828"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="385"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005109508.1"/>
        </source>
    </evidence>
    <sequence length="741" mass="85603" checksum="3D0C8F54A4A18AE8" modified="2025-10-08" version="1">MSLKPRRVDFDATWKLLRETLEGVITCGSVQRVTWNDRFSDVYKLCTAVPEPHGDSLYTSTKEFLEDHVRNLHKDIVASGEDHMLEMYHKHWERFNTGAGYLNQLYGYLNNTYIKKQKYSEADMNYGVFPVDADCLLEIGELAKDTWKNLMIDPIKNKLVILILSEIAKDRNGYDVNQTVIHSVVTSFVDVSEYKKKLPLELYQEVFEIQFLKETGDYYRHEAARLKADCSCSEYLEKVIQRLDNENFRSRKFLHSTSYAKVTHEVQSRMVADIIDFLHGECKDMVVQERRKDLTNLYILLKPIHKGLEVLVREVEGHIKQQGMESVLSLKNDPSFVEAMLKVYYKFKELIADVFNNDQAFTGALDKACSAVINHKATNTRAPNRSPELLAKYCDSLLKKSTKGIGDAELDEKLNGSIIIFKYLDDKDVFQRFYSRMLAKRLIYSQSASMDAEESMITRLKQACGYEFTNKLHRMFTDVSVSADHVNNFTTYLRSKNESLGINFNILVFQAGAWPINQPNNITFNIPMELEKSVQLFEEFYSKKFSGRKLTWMQSLSNVELKLCYLKKSYIVTMSTFQMATLLPFESSDSLQFSDIRTSTGLPDRELCKQLQTLVDTKMLTTEDEKPVNETSVITLNLAYNNKRTKFKIMAAIQKETPQEVESTHAAVDEDRKLYLQAAIVRIMKARKTVKHNNLIQEVISQSRSRFTPSISMIKKSIETLIEKAYLERVFGTTDEYSYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6Y4</accession>
    <name>A0ABM0K6Y4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Ubiquitin-conjugating enzyme E2 variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101853586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110178.1">
        <property type="nucleotide sequence ID" value="XM_005110121.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828699.1">
        <property type="nucleotide sequence ID" value="XM_035972806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853586"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021134" evidence="1">
        <location>
            <begin position="24"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828699.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17385" checksum="CA73AF12C6CF0371" modified="2025-10-08" version="1">MVTMVDWKVIPQTLLLMLACAQAPIPRDFSLLEQLEAGMGGAADGTINWGLADENDVTLTYWTAMIVGPLSSPYEGRIYTLSLECGPEYPAEKPTAKFLTRINMKGVNSATGEVPPSTISEACGSSNPTCTLEEILTYLKASMSAPENKKLSQPSEGSLYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7G6</accession>
    <name>A0ABM0K7G6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847772 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110565.2">
        <property type="nucleotide sequence ID" value="XM_005110508.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847772"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031643">
        <property type="entry name" value="DUF4708"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28495:SF1">
        <property type="entry name" value="GENE, 17266-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28495">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC100359752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15813">
        <property type="entry name" value="DUF4708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4708" evidence="2">
        <location>
            <begin position="5"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110565.2"/>
        </source>
    </evidence>
    <sequence length="688" mass="76272" checksum="9E4FC91A08B51BBA" modified="2025-10-08" version="1">MDSVIFFATRPDFENLCCITVCCDMEGSFPNSQMKAQGEGLPLQSHIWKCRELIFTEPGVLGSPAYEPGHIFHIVMTQDLYKTGRVQARLQTQGLLPSKPHRVSAPLYQTCLHYTVLAKLAPEWNKVGDWYIKGKDFLSHTGHAYAIKMKLSVNKDEIFIALTGTVVRCPPLQVEDLDLSEKEKLDVLKLADSDTQSISLEGFRCHVLPSMKQGWVTSLSLLIPEESPFNSYRDFCRYWKNVYGYRLPRTDEAILYCQVSFFSPGKGKKFTYPNVCLRVHPLHVMGRVDPKPVLKCFLQDLHSRVNTVCGMPLRFAPRIQFPVPSLVNSSQAGEHASLSNKSHKKSAIPYRSSQSVNRLLHGPPNNGQSSCNERTERPIVPLPDRSSESVSCRAENRDNSQLCTVKEADNNARESSSGRAVGNVGEQQSLSKSVHVDKPSPSSGPKGLKISNINKTPSGLPLVGSKDPPSVPQKSNSCEHSFSGSSGPESKTNPTAPRFVPRFKPKQMLQQCSVQKKSGEKVSTLNERKSDKLVPVFKQTIRCPFQVPDTPVISGRIPHHEIETGNASIARESPGAPMKPAFGKPSHVLSHQKKFSGNKSLSASPSVCKNLKRKAPIPGDPPKKARTAPQVQDVDVEKLARMNQLAKVNSASLIAWLKERGVACRTREKKMDLMNKVCHHLHISAPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7V5</accession>
    <name>A0ABM0K7V5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STING ER exit protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101862310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STEEP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110868.3">
        <property type="nucleotide sequence ID" value="XM_005110811.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862310"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029704">
        <property type="entry name" value="STEEP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355:SF1">
        <property type="entry name" value="STING ER EXIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355">
        <property type="entry name" value="UPF0428 PROTEIN CXORF56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="4">
        <location>
            <begin position="52"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005110868.3"/>
        </source>
    </evidence>
    <sequence length="245" mass="27911" checksum="F57768DB5D6F30B1" modified="2025-10-08" version="1">MCRGGFGLIGLCVSRSRSRYISSIFSICFLKMPKVVSKSVVCTDTKDQEEYQGEKPLYVYYCLCGQMSLILDCPTEKLPLRKRDGARVIDGQKHAHKLTCDPDEIVYIKRAEGLEKQYRQKCKRCGLLLYYHHQGNSSVMFIVNGALKRESEGVRTDVYSKLSKPKKVTLTKHTKNMGKFSSVTVSTVDEEEEELEAKEIADSYAANAKVIEKQLMRKGMSKRKLMEQAEEEAKKMRPKGTLIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAD3</accession>
    <name>A0ABM0KAD3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101845975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112773.1">
        <property type="nucleotide sequence ID" value="XM_005112716.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845975"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010221">
        <property type="entry name" value="VCBS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01965">
        <property type="entry name" value="VCBS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005112773.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24919" checksum="9AE180D963CCF807" modified="2025-10-08" version="1">MNRLFGRGKPKEPPPNLTDCISNIDSRGESIDKKIARLDIDLKKYKDQMKKMREGPAKNQVKQKAMRVLKQKRTYENQRDQLGQQSFNLEQQNFAVQSLKDTKTTVDAMKIGVKDFKKAYKTVDIDQIENMQDDLEDLMEQTNEIQEVMGRSYGMPELDDDELEAELDALGDEIGLDEDSSYLDDAVAAPSAPTSEPGGESMRGDVPVDEFGLPQIPQSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAH7</accession>
    <name>A0ABM0KAH7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Agrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101856397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112864.2">
        <property type="nucleotide sequence ID" value="XM_005112807.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856397"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004850">
        <property type="entry name" value="NtA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03146">
        <property type="entry name" value="NtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51121">
        <property type="entry name" value="NTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="NtA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005112864.2"/>
        </source>
    </evidence>
    <sequence length="274" mass="30411" checksum="C26AB2E78F425091" modified="2025-10-08" version="1">MFRGEVEIKRIFKGGQVLDTLATITPGLLRQHKMVMVEGFGDPEICDNVVKERDTKIFMLSPNGNGELKLNSSVVPLTLHNLDYVDSVVNHLPFITEKPKQISPCYLYFCPFGATCRVDEETMTPMCVCERKCSKIFAPVCGTDMVTYSNLCMLERASCIHNKLIKVKSHGVCGVRDPCEGHVCKFGAECLPSQDGERARCQCPNDCPSYGDHVGSQQICGNDGKDYANMCEMRKAACYQLKDIRIKYHGKCDPCQGHTCEAPKLCQVGPAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZF0</accession>
    <name>A0ABM0ZZF0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101851731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101851731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012937686.1">
        <property type="nucleotide sequence ID" value="XM_013082232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851731"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF263">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047044604" evidence="6">
        <location>
            <begin position="30"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="164"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012937686.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39438" checksum="B0484E1A4EBC33F3" modified="2025-10-08" version="1">MESHPYPGIMRVFLCQLICLIVVPTLCLGYVDMYVSPYPARVYQQAPADLAVARVRASDNETGQPVTSFRLESRNDARYFKVGSDGVIRTKTTISFKVGRIFQFFVFAYGTNQTCEDENCDVKASNDSYKHVKIEVSAKNEYAPRFLNQTYTFPVYRYGVADVIGKVTVEDDDVEDYNRHFSIFAQPGQEDFKYISLESDGVLRLSQPVPDEIDTLNVKLLAVDTGSPQRSGTTDVIVDVILVKQPETFCFSTTATTTTLCWKNPMPERAFDGYTVTVTGDSRRGDFLPYIDGHEEYCYPLNGTKVGEQYIFRVSVQSDDLWYGEEFDIVFNKSGIGYSRDCVEREFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZH0</accession>
    <name>A0ABM0ZZH0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011713</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937718.1">
        <property type="nucleotide sequence ID" value="XM_013082264.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011713"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046727633" evidence="1">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937718.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12282" checksum="55BA386405F03D19" modified="2025-10-08" version="1">MRVLRKGYKKKLLVLLSISVVSLPLTWLVGHSPQDGATETAQDERWFHPSLYGGDVAQQGKLLDSWRYNDLTNALDHAYRSQWVGFTNLSRVNCSQAFSPECRNKAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0H5</accession>
    <name>A0ABM1A0H5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101845240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938333.1">
        <property type="nucleotide sequence ID" value="XM_013082879.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845240"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="10">
        <location>
            <begin position="162"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="495"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="544"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012938333.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="69550" checksum="C515ADE8F5B8F7B9" modified="2025-10-08" version="1">MSFQLNMPPSAVARKLKQEQGEDGDEPRKQSREEWKKERELEEMRKAGTAPAMKDEEGKDINPHIPQYIMQAPWYFGAETATLKHQRQQDEKVPKYDPLNVQLKKGVKEGPVAVKFRKGACANCGAMTHKKKDCLERPRKVGAKFTGAMIAPDEHVIPQLKMNYEGKRDMWNNFDAEEHQKRLQDEYKEIEEAKRALKEKSLDESLMTGKGPTDAENGEAASDGEDEDKHYTEEMDMPGQKFETKQRITVRNLRIREDTAKYLYNLDPNSAYYDPKTRSMRENPLKNTSKEDITELKFGGDNFVRFSGDAQEMAKRQLFAWEAYERGNDIHLQADPTKLELLHKEFERRKGDFKQTAKDSILDKYGGQEYLEAPPKQLLLAQTEDYVEYSRTGAVIKGQERAQIKSRYEEDVYPNNHTSVWGSYWKDGRWGFACCHSFIKESYCTGEAGKQAELESNLLVPVATQVDTVPETLLEKHQKKLKEGEKKKRKKKSSKSSSSSSSSSSATTPASTSSSKSGLGTSTGTKTQTNTASNSAKPPSGVQTSASSSSTSANPPSSSQFGVKSSFASSSPSVKPVNFSGVKSLSSSSSPASGNVPSSASVSSSSNPVAASVSSSVTPSKSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1A5</accession>
    <name>A0ABM1A1A5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor A domain-containing protein 3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938803.2">
        <property type="nucleotide sequence ID" value="XM_013083349.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846215"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46785">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46785:SF1">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="174"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="542"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012938803.2"/>
        </source>
    </evidence>
    <sequence length="827" mass="93230" checksum="9C2B103A0BEDE0CD" modified="2025-10-08" version="1">MTSVANRFLSVDPHMKNAFSSTVKFDMGPAGPSPLARVPASRKTDINEAVEVAIRANPPREWELDVRALTSSRKWLQNYGLKKGRLQLNQILPAIGFKLSDEFDETLKKPVSSRYGGGLFRHLMRADGKTFNVSCSKDKLIQLEKRLLQAIYLFRRRLEWLTTESRRTFGVVEERAVTVVLDIRNMSPQQFDQYRTALERVLREQVSQLAKFNLIRASEDIQLYSPDCAPVSHDTLENAIQWLWNLDRLAPVSNTSATEAILAALSDQHNEAVYLFTEGTSIDSGKEVLLEKVSTAKTKVPINVVSFNCDSSNTIKFLKDFVKTTGGKFHAYAVVMELDAYEAQPADGVTSKANILLRRKTFGGIPAGAGVREDVVLVFEEMEQARNNLAQVRMLIENAPDPNRASKGIDPDLPQAVCGRDEQYMSSREWLDIYGLNSRKLGLYDVLSGVAFKHQDGVVDVMHRPATDTQTDAVVQQKLINARYCEQFPVVRWKDGRVVHVQVTPEVHRSYEERVMVALNKIQQRVDWLNQGSRALFGTLCEDQLYVLVDTSASMQPSLGFVKQKLFVLMQEQLRHKKKFNIVTFNSKAAAWKDRLVDVSERSLQSAWSWVQNLSCWGSTNTYAAIQLAMSDPQTQAIYLLSDGRPDQPPKSIIAQVHMKQHIPIHTISFNCEDREANQFLFDLSEATGGRYHYFNDRGKPVDQPESWESVDIKLLKEEMRRGFENLDKLADLRDECTSLAWKRETDSLRQSIETAREVKEGLSRSAMPPLDPKDLYRPNTPPHPPATPPPPRPSSAGPSVSRTSHRSDGPPDVSDSLAPARPTPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A254</accession>
    <name>A0ABM1A254_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 1 regulatory subunit 12A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRARP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939298.1">
        <property type="nucleotide sequence ID" value="XM_013083844.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854873"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012939298.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27133" checksum="A92E8EA71E8EA504" modified="2025-10-08" version="1">MSRRASLLAKQEHRKPRVRFPDELVFLDNMKGNDIQACHSMLRRASVQMDINGLDNNGVTPLHNAVLEGNLAAVKLLVQHGAEVNKKDVDTWTPLHAACANGEGDIARYLLSKGASKDIKTSDGERPLDLCDARDFSVISVMLESDKARRAKLLKTREDDDDDDDIDNNNDDEDNGNAGKLRSRSKRDDNEDNDNSDPSSSTTPPTLSLGSSSQSKTSSSSSVLSRPPKPPGHSILKKSPQKFNSVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A262</accession>
    <name>A0ABM1A262_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription initiation factor TFIID subunit 4 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101858188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939308.1">
        <property type="nucleotide sequence ID" value="XM_013083854.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858188"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1110">
        <property type="entry name" value="TAFH/NHR1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037249">
        <property type="entry name" value="TAFH/NHR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003894">
        <property type="entry name" value="TAFH_NHR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07531">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00549">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158553">
        <property type="entry name" value="TAFH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51119">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFH" evidence="8">
        <location>
            <begin position="538"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="940"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1027"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012939308.1"/>
        </source>
    </evidence>
    <sequence length="1087" mass="116870" checksum="4DB5E7203DA310B9" modified="2025-10-08" version="1">MAEQGSMDDLLSTEIDENKVTALVGSLESQLASATGKESHKVVSASSFNNNHIGGNASLASTPGTVHNSRPQHTVVSVHGLSAHQSAISANKVVPQSTNIINSVKGSLSNPQIIGISSIGIESINSSSANQQALNRNNSNSTSLSNANVPQQVHTSKHLTNSPSIRIVTNNSKPPNSAAGQIQTSNTQFLNSAMSQSVTIRPQGHALNRVNINASGASTAIHNLATIAAEAKPLIVLPNGSNHLQNVQHKDGSVIPHQIVVKSDANHAVKREVNPLVKSDISMPNSVIQGVRQGAPIISSGTQHIRVTGTSNPSIVAVRTNTPHSQHVVVRATVATTLANSSPSVQVVNASAAGTPSTLRPTVTPQIRPGQVRISNPVRTAAPQNIAPRQQTSQTGTIAIPQGALLIRNESGHLVIVSAPQSVIQQTPSSNSVITTIAPSNYRVQNVRPLATPAPVRTVGSGQTIVTIQPQGAPQHQPSQQVRGPAISTVVQATSLPRPPRPTMSVVGQPAQAVGQPAPSTPAGGSVAAPLEMNKAMMENVKKCKNFLSTLIKLAYSQPEDTVRNVQALIQGLIDGRVEPEVFTERLQHELQSSPQPYLVPFLKKSLPLLRQSMLMGRMSIEGVRPPPTQTVSQPPTTTSSQPVVTTQAVVTQQVITAAGTLTTRPIVAPVVQPQQQQQVRPKMRPSPGPASSKVAAIRQSVPQVAITSGGNKMVVHAAPQGPRLPQPVSQVQRPPQPQRLPQPQRLPQPQRLPQPQRLPQPQRLPQPQRLPQPVSHGQLQPVRPKMASPRPSAPVVRAQRPVIAPTAVVKQEPSSPAPGHREKRKFESLKDGDDDINDVATMGGVNLSEESKNILATTNADSIGAQLRSCKDEVFLAASPLLRKITAIAKKYGVEEVNPAVVSLISHATQERLRDFASKLSIIAEHRVEIYKMDSRYEVESETKQKLKFLEELDKLEKKRHEEHQREILLRAIKSRSKNEDPEQLKLKQKAKELQQAEAEELRQKEANLTALAAIGPRKKRKLDLSDSGVSGSSSTSNTLSSNLNSSRPAVMRPRIKRVNMRDVQFLLENEKATRKSELLYKTFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A272</accession>
    <name>A0ABM1A272_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Filamin-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101845933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939324.2">
        <property type="nucleotide sequence ID" value="XM_013083870.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845933"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21311">
        <property type="entry name" value="CH_dFLNA-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21315">
        <property type="entry name" value="CH_dFLNA-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="30"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="154"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="264"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="364"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="465"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="569"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="657"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="755"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="851"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="942"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1139"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1329"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1425"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1521"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1614"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1708"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1796"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1892"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1989"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2083"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2178"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2303"/>
            <end position="2397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939324.2"/>
        </source>
    </evidence>
    <sequence length="2398" mass="257007" checksum="FC43662F17E300B1" modified="2025-10-08" version="1">MQYEEDPDWDEEEEMTTTERELADDAQWKLIQKNTFTRWANEHLKTVNKQLADLESDFSDGLRLLSLIEVLSGKKFKHVNKRPNFRTQKLENVTMVLKFLEEDEGIRIVNIDSTDIVDKKLKLILGLIWTLILHYSISMPMWEGEEPTPSEKAPTPKQRLLNWIQSKVPDLPINNFTTDWNSGKAIGALVDAVGPGLCPDWEDWDPKKNKNNAKEAMDAAEKWLDVPQLIRPEEMTNPKVDDLSMMTYLSQFPNAKLKPGAPVRPRLNPSRVRAYGPGLEATGNQVGAPARFTVETFSAGKGSVEVIILNPKGQKEPCEVNFNNDRNMTYSCVYVPSMEGAYRVIVKFSNKEIPKSPYTVQVEGAAGDPTKVTAAGPGLEKTGVVAGKKTYFEVYTQSAGKGTIDVAILDPHGHKDKIRAAISPVVGKEGTYLVEYTPIEPGLHSVNVFFSGTQIPHSPFGVNVAPASNAKACYATGRGIQPRGVRVKDKAVFYVHTKGAGEGAVGVQIFGPGGIEEKCSVKPVQGEEGVYECVYTPSKPGNYIINVTFADQHISKSPFKVEVGPFWNTKIRAYGPGLEGGVVKQPAVFTVETNGEVGALGFSIEGPSQAKIDCKDNGDGSADVTYYPTVPGEYAVHVLCNDQDIPDSPYMANIIPEQPFDAGRVVAKGPGLEKTGVVANKWAEFTVDTKLAGKPAPLNISCMDVDYKPVDVQVKDNGNGTYSCRYMPTKNVKHTVTITYGGVMIPKAPFRVYVSEPSNPSKVKVFGPGVEKGVKTFTPTYFVVDCKEAGPGDVAVGLTDERGVDVPVKTTDNQDGTFTVEYEPKSPGQYTVLVYFANKEVPQSPIKVKVEPNIDVSKIKVVGLEPTMPIGVPREIGIISKGLPKAETKVKVVSPTNQVLEVPTTPTGDGAKATFALVEPGPHQVEISYGGAPVPQSPFQVEAVQGPPRVKAYGPGLTGGEALQPAVFTIDTREETNPGGLGLSVEGPSESQIQCVDNKDGTCQVTYVPPVAGAYNVNVTYGERPIPGSPFKAQIQPGKPGIDVSGIVAYGPGLNPAGVFMDCPNEFTVDAKSVSPTAQGKVKAIITSPSGQRTDTLVKNNGDGTYNVLYTPFEQGPQQIEVTYEDLPIPQSPLTVNAIPGSDASRVKAYGPGLEGGLTDEPAVFTVDMKGAGKGGLGLGIEGPVETPMQCQDNHDGTCQVVYQPTKPGPYDVSVKFNEQHIPGSPFRVGIKNPVNPAKVKCYGPGLDSREVKAGMPATFTVDTTEAGEAPLEVTFTDSTGAKRPAQVTPVEDGIFNATYVPTAEGPCQVEVKYANQQVPNSPFNINAQPGVDASKVKVTGPGISSTTPASLPAAFHVDTREAGEAPLDVFVKRPDDTYIRPFIQDNTDGTYDVVYTPEDLGVYDVAVQYGSQDVPGSPYNVKATPTGDASKCKILAGDDRTIPVNKETVITVDAAQAGVGKVTCRIRSPNGSDIDIDIIEQGDGTFSISFTPQFAGPYTIEIKFGGELIPNGSYTVQVGEDLITADKVDSVQATAPGSGLFQPVDFTLPVGPIFNFVSATVVMPSGKRAYPNIEDNKDGTVTVRYQPTETGLHQLHMQYNNEEIEGSPFLFHVEAIDSGFVTAYGPGLSHGVVHENAVFTINTKNAGAGGLSLAIEGPSKTEIQCKDNEDGTCTVSYMPTAPGEYQITVKFADKHIAGSPFTAKVTPGEPRRKNQIMVGSSSEVSLQVTEQDIESLTATIVSPGGREEPCFLKRLANGHLGITFTPRETGPHIVNVFRNGKHIPNSPFTITVGESELGNASKVKVYGKGLEEGMANEVNEFIVDTTQAGYGGMSLSIEGPSKADIECHDNEDGTCRVTYKPTEPGTYIINIKFADQHVPGSPFSVKIGGEPSAKITERITRHKEAADVSHVGSQCELSLKIPGTTPFDMTASVKSPSGVTELCDVVSLDDSHYSIKFVPQEMGVHTVSVKHKDMHIPGSPFEFTVGPIAGGGSHKVHAAGPGLERGEVDQPADFNIYTREAGAGGLSIAVEGPSKAEIDFQDKKDGSCNVTYQVSEPGEYYVSVKFNDEHIPDSPFRVNITPSIGDARKLSVQSLQDRGLQAGKPAAFVVNFNGAKGRLSARVVSPSGTEEEALVQEIDDGQYAVRFIPRENGVHLVHVLFDNYHIPESPFKICVGKVDADAGKVTAYGDGLKTGKTGEVAKFIVNTVNAGSGSLAVTVEGPSKVKLECTEVDEGYEFSYNPTAPGDYLICIRYAGVNVAGSPFKAKIEGQGQPSAMQEHASVVVETVTKTSTTTRFSGIQRFSSDASKVTAKGNGLTKAFRGKTATFTVDASGAGNNIMYIGMMGPKGPCDELVVKHQGNLQYAVQYMVKESGRYMLIIRWGDQDIPGSPFAVDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A398</accession>
    <name>A0ABM1A398_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101857346 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101857346 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101857346</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101805.1">
        <property type="nucleotide sequence ID" value="XM_005101748.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939941.1">
        <property type="nucleotide sequence ID" value="XM_013084487.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857346"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939941.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="30819" checksum="C927AC29A32F285B" modified="2025-10-08" version="1">MKQGVLFNLVGTVLIVAATVLHIVCLSTPYYTEVNMDEMAKKMEQRRPGGNGLFSQGGMDSTSMDESDEASNMEDHTSSIGRGLGENGGMGSDLMSDNGGFDESPVEGYHEASSGVVSSSALDGLQGKINFGIWKFCVSVKNTFSACMEWTSQDTASAGTGIGFKAPGWLYGVQAMAVIGSIIVGIASVLSVINLVRESKGDRLRLLYLIIAATCVAGGVFILIGDIIMASKYSSVLDGMAQGQVPPQTWSFIKDQFYLSWGFALDVVSVAMAVLAGVAHVVAGRAALSANGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A407</accession>
    <name>A0ABM1A407_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Importin-7 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940368.1">
        <property type="nucleotide sequence ID" value="XM_013084914.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850736"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012940368.1"/>
        </source>
    </evidence>
    <sequence length="1045" mass="119130" checksum="CE8BABE092608BAB" modified="2025-10-08" version="1">MEVTKLVEVLRATLDPNQREQAEQQLTEVHKIIGFAPVLLQVVMADQVDMPVRQAGVIYLKNMLTQYWMEREPENVTDNVPFNIHEQDRQPIRDNLIEAIIHAPDPVRVQLCVCLNHIIKNDFPGRWPNVAEKMAFYINSDNHAFWMGALVSVYQFVKVFEYKRCEERQTMDDTMKHMLPILYQRLVQLAQEPSETSSLLQKQILKIYFAYTQNYLPASVLTREVFTQWMEAIRQIVERDVPPESNQVDEEERAELACWKLKKWSVHILARLFERYGSPGNVTKEYNDFSEWYLKTFSCGVLNVLLKLLEGYRQKVYVAPRVLQQSLNYINQGISHAFSWKFIKPYMQTMIQDVIFPLMCHNDEDDELWNSDPLEYIRIKYDVFEDFLSPVMAAQTVFHSATAKRKEVLNKAMGFCMSILTNTSSEPRARDGALHMVGAVAQVLLKRKIYKDQAEQMLTTHVFPGFASGHGFLRARSCWVVRQFAELKYRNWQNVNQAVELVKVALCTDKDLPVRVEAAIAVQMLITEQEKAKTYIQPFVKPVILELLNVIRETENDELTGVMQKLVCTYVEDVTPIAVNMMNHLAQTFAQIIESDSDGSEEKAISALGILNTMETILSVMEDQKEIVVQLEGIVLSVIGIILQNNIIDFYEEVLSLIYSLTSTQVSHHMWEVFGMIYQMFQKDGVDYFTDGEKILFLDMMPALHNYITVDTDAFLSNPTYLEVIYNMCKQILNTDVGEDAECHAAKLLEVILLQCPGKVDHVLGSFVELVLQRLTREVQTSELRTICLQVVIAGLYYNTPLLLDVLGKLNIPSINGSVLGQFLNQWLVDTDCFLGLHDRKMSVLGLCSLMSMVGQRPQEITEAASKILPAALLLFQGLKRAYASRAAEDESDSDDTDVEDDEAYDGEVLSSDEDEIDESSQQYLERLEKAANRGDDEDSDGELTDDGAEETALESYITTLDAENCPVDEYVTFKNILTTLPTQDGGWYQAMVNGLNPGQMKEIEEVFKLAEQRKAVTDSKKIEEGGGFSFTNRQVPSTFNFGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4I6</accession>
    <name>A0ABM1A4I6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101851589</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101851589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940693.1">
        <property type="nucleotide sequence ID" value="XM_013085239.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851589"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012940693.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41177" checksum="E947D5C4BE0D0DCB" modified="2025-10-08" version="1">MDRTRAFRPSEIFFTNEMRAISELVMDFIFSFVIAIVGVISNMLVIVVFAKQGFSESVNISMTTIALWDFAKCLGGAMQRMAGPIKLLSKADAESWTNISVVIFNYLICFSSYVTSALAAYVAVERCLCVSIPFKVKWLLTPKVTLIVCIGISVVVFGSFVVIYGIYDIYWLYNPTYNTTTAFYRYNDFFYEHRGPLFEYYNLSGIIWPTVSFVVIVVSTSIIVSKLREGSKFRASNADVVGKSDSGSQLSSRDRQVVKMLVVIIGVYVFNLSPRIALYMAKYFIYEFYFLREYHNLFVFVCYFLWVFDLLNGAINFFIFYKMSTSFRDTFLRLICLRKPQADSNKPVNKQSVTHTTSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5K7</accession>
    <name>A0ABM1A5K7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acrosomal protein SP-10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941259.1">
        <property type="nucleotide sequence ID" value="XM_013085805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012544"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012941259.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13503" checksum="484C9FF45C8B705E" modified="2025-10-08" version="1">MGQHIMGQHTMSQHITGQHIMGQYTIGQYIMGQHIMGQHTMSLHIMGLHIMGLHIMILHIKSQRILGQHIMSQHILDQHIMSQHIMGLHNMGLHITMHQESTHHGSTADHKSAHHKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5N3</accession>
    <name>A0ABM1A5N3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101851882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012941306.1">
        <property type="nucleotide sequence ID" value="XM_013085852.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851882"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF395">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="351"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012941306.1"/>
        </source>
    </evidence>
    <sequence length="688" mass="78848" checksum="D4CC27628C7A28F9" modified="2025-10-08" version="1">MAASPSRELEEYWNEFHTIEQQHADTHSDEDELSKTPDEGEMEAAWLARAGYGFVVNKFQDGKDLSDGELDTLTHSLTRAQAEAVRKRINVLSTTMRRKNRVHKVHVKDIFPTQLHGHQHHNQHHHSGGGGDGGGGGGGGGQANARLGLNGGSSGGGSGGEGSSSKDTTTTTTHHFVRRRSTRHRNYMSRAQLHDAVELPDGYEQRTTLQGQVYFLHTRTGVSTWHDPRVPRQVGMEFRDEDLGVMPEGWEVRMTPSGRVYFVDHNNRTTQFTDPRLSQNLHLIQERLKSPSQDKENEQPNLPKYKRDLVQKMKVLKQEISALQPQAGHCRLEVSREEVFEDSYRQVMKMRSKDLRKRLMVKFRAEEGLDYGGVAREWFYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSGVNPEHLSYFHFVGRIIGMAIFHGHYLDGGFTMPFYKQLLGKPVTLDDLESVDPHLHRSLCWMLENNIENVLDHTFSVEHDSFGCMQEYELKPGGTEITVTEENKREYVKLYVQWRFMRGIEAQFLSLQKGFNEIIPQHLLRPFDERELELMIGGLGKIDLDDWKKHTRLKHCTAETNIVRWFWRAVDGFDDEMRARLLQFVTGSSRVPLQGFKALQGSTGAAGPRLFTIHQVDICTDNLPKAHTCFNRLDIPPYENFEKFLSKLTCAVEETCGFAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7M9</accession>
    <name>A0ABM1A7M9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101845869</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942420.1">
        <property type="nucleotide sequence ID" value="XM_013086966.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845869"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270">
        <property type="entry name" value="ARMADILLO-TYPE FOLD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270:SF2">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="279"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942420.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="59762" checksum="4296062C2D1BCAD0" modified="2025-10-08" version="1">MLKQMNSLGIFKNDDIWFPTYYTYMTLWNYSDASEKLARSLAESGAVKLMTLNLGHKPYLDNMHSKNVYYVLKASLSILHNIARCTGVKHHFKEIKTAEVVMPLISSNDEFLKSIAMLTLAYIVEEEENAKLIDETNTIKNIVTWIHRALENKQKRRFRGFTPWELTQGLAKLAVNDSNKAKIIEEGALGDFLSMLRHTDPKEQANSAECIWTLSFDKTVRQAIIDFPELVPALEELQEHENTVVRKNVKGALWLIKGENDPAASSNRPHSALAPKNHIFISYSWNEKELVKKIYNSLAAEGYKLWVDWEQMGGSTLQAMADAVENSAVVLVCMSERYKQSPNCRTEAEYTFQLRKDYIPLMMQKRYRPDGWLGAILGAKLFFDFSGKYPYEKPLQGLLKELRGRGKSAHPGGVNSVDETDASPDAVQPVVNNVALTTSSPSTPINSLATTSATCVAMNHEHVENWLVSKGLQRFSNAFSQIDGQLIWQLKKMRETAPEYFHNSLERQFGMTLIDILRFNAALDSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A999</accession>
    <name>A0ABM1A999_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101855138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943266.1">
        <property type="nucleotide sequence ID" value="XM_013087812.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855138"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943266.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25409" checksum="A0393FC596BCB49F" modified="2025-10-08" version="1">MAFANDYRYGVVAAGGEKKEHLYKILVIGELGTGKTSIIKRYVHQFFSQHYRATIGVDFALKVLNWDVDTLIRLQLWDIAGQERFGNMTRVYYKEAVGAFVVFDVTRASTFEAVTKWKNDLDSKVQLGDGTPVPCVLLANKCDQAKEGLVNNASQMDEFCKDKGFIGWYETSAKDNINIDEAARFLVTKILEKDKAIGEEDRDRDRVVLDSNDVTSKPEKKISCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9K7</accession>
    <name>A0ABM1A9K7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrin-linked protein kinase homolog pat-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943437.2">
        <property type="nucleotide sequence ID" value="XM_013087983.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856841"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0401">Integrin</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012943437.2"/>
        </source>
    </evidence>
    <sequence length="141" mass="15716" checksum="F4E1685B109F2049" modified="2025-10-08" version="1">MSDTKLHTAVRYGSADAVLQALKQNLNPNHIGLFKWTPVHEAAHNGEREILKLLLHYKGDVNIKDELHGNTPLHYAAREDNSACVTVLLKAGAATNLQNNEGMTCVDVATSLCKEVIEQYGKLHFCFPYLTLMRCLLKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA13</accession>
    <name>A0ABM1AA13_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Progesterone-induced-blocking factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943699.1">
        <property type="nucleotide sequence ID" value="XM_013088245.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857602"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026205">
        <property type="entry name" value="PIBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950:SF0">
        <property type="entry name" value="PROGESTERONE IMMUNOMODULATORY BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950">
        <property type="entry name" value="PROGESTERONE-INDUCED BLOCKING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="584"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943699.1"/>
        </source>
    </evidence>
    <sequence length="776" mass="90446" checksum="A597F9A1E5F006E1" modified="2025-10-08" version="1">MAARDLSKTFEEIESEDFSLETSVPTDLTMSPDHSEAETRNKKRHITKQIIERKQMLHDMQLLKIEVSQKNLALENLKAEHLQQTEELEEKLHDATHQKQILQARLESELQIQSDDARKRQELIKRELDGVRSRQQQLEAANERLQEKAGDVRRSLRDLTISEERFYQLRGLPEEELSLRDYVAMRQYEAVKPVQTEVSQLRSQNKSLEEEVTGLSRQLLDVQKNLEEERQAHGELRVKYQKATTDYAETATRVKVDDYKVENYDRVKSERDSFEQDQLESVRQLVAAEASLAALQKERDDLSRELSSSKQTVALLRQDKDYLSRQCSEASHKHAFGEEKLQQLSRQLEDAKLAREEMYEKYVASRDQYKSEYENKLKEELEQIRVRTNGEIDRLRTSTREMYERENRNLREARDMALSERDRVNGTERETAVKYEQLLTEFRQLQATSESRVSEVQNDLKVKMFEAERTQMIHSETVKNLGQAEMDIEKMQKKVEVLTKEYYSLQASMDKKVVELEASVSDKTARLATYEKLEQDLDTVVMQAAEVEDEKDAERVLFSYGYGANVASTTKRRMQQSVHLARRVLQLEKTNTSLRQELQEHKSKADQLVKEVENTNNLLDQSQQPYGYLINSIRVRDGQLQQQAGHIQVLEDDLRKVSQEREELARTHNQMSLDLERLLNQKEEMSVMKQVVLSLSERKLDTHKARSRDFRPTKSVSSLGHRVQKDFELQDEPNVVKPGSLHLSKPRSPLKSRGQNKKQSGGLEPKFSKVYGIAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACB3</accession>
    <name>A0ABM1ACB3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860934</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944986.1">
        <property type="nucleotide sequence ID" value="XM_013089532.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860934"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053075">
        <property type="entry name" value="TNFRSF11A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47134">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47134:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944986.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="59822" checksum="67E0EA91A1B90C23" modified="2025-10-08" version="1">MAAGSEEDGEVRTDVYDGQKEERRLREEEAGGGKKEGEEKEDVDSNAMWNTLYKIGGALEPLMPSDRNSNGVCPKSATDSCPSGHQLKQCKTGQGFFCEQCSDKTFQPNENWMGDKCRLRRNCRKANMYYLDEGSTTRNANCACIDGYHFPNEDQRACFSNPICQKGYAPGMYGNCESCQKKGMFSDTVGRVKKCKPLTNCEKRGRCTDVKSNGQFDNICGPKVTDLSTCKEIEPSSSSSDVLKIAIPAGIIGALLLIILFIFFVRRKKYRRQQSSKRVLTVEEMDELKLRITKASDRDPAVCKKVLTTSCSFIEERIERQIWDLARELFRPHHIDGKYELIVDKYKESQAKYTVNGYLLEWRDWRGDSKDAVAELFRCLRQVKRDDIINEICACLRNDIEFSEDSQRQSRHSSNKKSMRDECVYIFFPCCYGGKEKSSSSSSSSSSHSSGAAVVVEADAGEAGTKLLAYPTDDIDEGSDSAGGDGGQRTAPGTFYRSHPSPSAPELDEPSGGGGGFPSLDNVKYNRQFSQPVQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD09</accession>
    <name>A0ABM1AD09_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Uncharacterized protein LOC101846617</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC101846617</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945363.2">
        <property type="nucleotide sequence ID" value="XM_013089909.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846617"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15664">
        <property type="entry name" value="ePHD_KMT2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15506">
        <property type="entry name" value="PHD1_KMT2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15508">
        <property type="entry name" value="PHD3_KMT2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19170">
        <property type="entry name" value="SET_KMT2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047219">
        <property type="entry name" value="KMT2A_2B_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE TRITHORAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838">
        <property type="entry name" value="HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="21">
        <location>
            <begin position="1189"/>
            <end position="1235"/>
        </location>
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        <location>
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            <end position="1641"/>
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    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="1674"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="22">
        <location>
            <begin position="2415"/>
            <end position="2523"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="19">
        <location>
            <begin position="6628"/>
            <end position="6744"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="20">
        <location>
            <begin position="6750"/>
            <end position="6766"/>
        </location>
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            <begin position="206"/>
            <end position="241"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="380"/>
            <end position="400"/>
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        <location>
            <begin position="442"/>
            <end position="473"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="489"/>
            <end position="514"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="545"/>
            <end position="599"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="631"/>
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            <begin position="788"/>
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            <begin position="1246"/>
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        <location>
            <begin position="1769"/>
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    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046336608" evidence="8">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="47"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012946316.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19352" checksum="CAC676C58B2F3ABE" modified="2025-10-08" version="1">MSAQHFFSLFVVCILMSFSQFVHHADAGYTLKEVEVVSNNGEPVRVFTAEELKEYDGSNSDKPLYMGIKGVVFDVSKGERFYGKDAPYNVLVGIDSTRAVAKMSLEKEDLNHDISGLSESTLKSLDDVFEGTYVAKYPIAGLGYSGDSLICSQPPHTTSYQSSVQIPKGSTADTDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEZ7</accession>
    <name>A0ABM1AEZ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Platelet binding protein GspB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946405.1">
        <property type="nucleotide sequence ID" value="XM_013090951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013982"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946405.1"/>
        </source>
    </evidence>
    <sequence length="1219" mass="127711" checksum="6754992D3F4D4D43" modified="2025-10-08" version="1">MGPKSSNYHGNSEEVSPRMPNVNGSSGGGGGNIFGSDIGHQGVTLIPLQTLYTHTPTPSEISNITARSAASPRSGMHTPALSVISNQERASALGATSRASVHTPRSSLHTPRSMLGTPRLEQSSDVSSGGKMHIQQPQQQQQQQRERDDVQLVALNLERRWHGIWLQSLEWQCRLEEALARRKGVSSPGLDFSSFQLPVLDESLFGRSSQNLNAQGFIELDDDSLLFIGRCEEDLADCASSSSVTSESCDSYSFSGCGDVTGFNAADHFASFPLSLASPLGSPSRSPYSSSDVIGEGVGGGVGGGVDGASGDPRPSSRFDPRFSGSGGDITPPGQRSPARPSTVLLSPDSPLGKRPFPDTGNSSGGSCGGGASPAKRGSPTPTSSSGGLSPVTPDAAPIEELLRFGVNSSAFQHVVDNTDDEYGDVLITDLQDDDDYDDSSVHESLKVKRSLLFDRSSGDSANISEAESKMGDSPRSSGSSGILSPPGVAAGRGAGNGGGGAGAGVGAGGYVVTSSDGELDPPSTHRAPPPVIVGVVSKSEVRDIGYSSESQSNDEVDVMRHQIDLEYKFPGKCEVASDGPLGDKVTMPSTKVKPQYYYMTHVDLDSTDRTTDNGDTTDSGPERVKDDVKSSSDGHGGYRPEADRFEAAVKEVYSELKDDDNGSCFPGQMSSRGHSGSNCEGGSAAVVSSSSSSSSSSAVRGHFGVSELVATGKSSASSATVSPLYIPDDDDTEDVTMLAIKPLHELLDISESDSAPESKEKKSIRYLIEHAEDLVKPPSPTKTTFSAPSSPSKHLQSPIVVQQQQQHQQHQLSPSKQTQTDSCSAVESSCDASGEDNSDHEAAAAAAANASGSGGTRDEFSTATDDADETLIGSVINLDSATESARNTSTDDIISTTCSGVPRSPRSIPHTLVDSPRLRKQTGESSSSRRRGKDRPWSVVGLQDFSSNSRGSGHGDKMGGATTMDAVDSVAHHNHHHNYHHHVASSESAIDHIFQRCQTDTDSSSSNAASPMMAASSFFFSPSSHSSTFPRESHQHNHHPRRGFRRALSSTEHQSPPSPSTKVHHSHASSSTRRKLKYSSEVAPAAADRMTLENGLVSDNGGGPLATSETPVPSSSLLCSHSKTGHYTAILSAEATSDSEAPPSPSKVRGQAPSSPGRVKGQQRRTRRLRHRSSLESGKEVSVSGSGGGVIGAGQPYSRSSATDSYDSAEAESESETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQL0</accession>
    <name>A0ABM1VQL0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011291</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824702.1">
        <property type="nucleotide sequence ID" value="XM_035968809.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011291"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035824702.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32331" checksum="8F159870BB78E643" modified="2025-10-08" version="1">MDSHNRGRGNRGRLRALSPIREVSGIVPVQVVPKGTKLMKGASGHAPILVQALPPEVTDPKPKMKPSDRHYTAVDQVVADYLHYARYGQVAPVLYGGGAGGGGLNCACCVDRNRENVARKLALQRGDDPNTVRPLSPARDLPEHYALPSTSQAMYTGRGIPSSNSYNDNTGKHTVRFQDDENARTHYHSPRTKQLVLSPPHAQEPWTHYQPTPYAGTFLNPEFNRPFVRQSADEESVWLSIEQNHIFDSVLEADSKFKNSMDKLQTHLKNNFTLPQDAVLLDKVDEQEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQV0</accession>
    <name>A0ABM1VQV0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Torsin-1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC101858771</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095165.1">
        <property type="nucleotide sequence ID" value="XM_005095108.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824792.1">
        <property type="nucleotide sequence ID" value="XM_035968899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858771"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF1">
        <property type="entry name" value="TORSIN-4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="10">
        <location>
            <begin position="471"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005095165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035824792.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="59975" checksum="98C9A89CBD53F141" modified="2025-10-08" version="1">MEPMDFDSEEPVYRHSSYRQASLSPPLPSVNRESDASDMDVDSNSPVQDSAHRQMSPRWSASLEHVSRAVSAVMSMSVGGKEPTDDNGGRMASKECEVSQATQRSHSWEPAATVVRGVVAFRKNKKTGYGIPDDDPTFSHFPGYVRDVQNERSLRQRSGNVLATPEASATPLNTKTAGQMSHPRGPPRKKLRVGSNETDVGQKSSKCTCKSVSLWTIFLFIIVCLIFYIHDWQDKRCKASKLFDKRSLEIDLESYVFGQEVASRMVTTELETYFHQLNTPSTSEEYSVSSKRASYGKNNVDLCKPLVMSFHGGTGVGKNFMSRIMSENLKRSKVMQFVIPHLFPHKVYNEIYSKQIQQWIMGNVTECKVSIFVIDEMDKAPPGVVSGIGQAVHSLSKPCHLAAPVIVLLLSNANAVEINRRFLSLRHAHPSSLIREKISDSKFMDIFKSESEWYFTLASSTIDVFVPFLPLEKSHVIQCIRRDLVAKGFSSNSDAVEKILRELSYSTFGDLHLSTTGCKRVQDKVDYVMMQVNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRM1</accession>
    <name>A0ABM1VRM1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101860803</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825063.1">
        <property type="nucleotide sequence ID" value="XM_035969170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860803"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="165"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="550"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="655"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035825063.1"/>
        </source>
    </evidence>
    <sequence length="931" mass="103828" checksum="9BFDAC80CF780EC3" modified="2025-10-08" version="1">MFVVNTVCFIKFKTYTHQLMQVKDERLKVLSEVLNGIKVIKLYGWEPMFAEKVAEIRNRELKILLKLSFIDIVETFSWTVSIFWMLYFILMTFVLVDSSHHLDANSSFVTLNFINLLRLATNVLPVLIQASAKVVTSVKRLNKYLNSEDISRQSLYRNTDDELPVRISEADFSWEKNGPLSLKSISLQVSPGQLVAVVGTVGSGKSSLISALLGEMHNVRGSFNLNSSVALVPQQAWIQNATLRDNILFGRSHDPDFYDRVVSACALLPDLDMMPAGDLSEIGEKGINLSGGQKQRVSLARALYSDADIYLLDDPLSAVDSHVGRHIFDQVIGHTGMLGHKTRVLVTHGIHWLTEVDTIAVMDDGHLTGVATLDEWVERGGAFAQFLSQHLHNDRGGDEEEEEGEDESIMEDGHISKAVFQRLVSITSEKSADDSAGETLHKSVHKQEAGSDVTLHVEKSGQKKEEPSKSKLITEEEMDTGKIKWSVYGEVAKAYGIGFTILTVVFFIANEVALDLGDLWLSAWTDDQPLSNFTQLPASSEARADKNEYYLLVYTGLGLAQTVLVIAYSIVLQCCKIKSCRKFHANLLHSVLRAPMEFFDTTPMGRILNRFGTDMEQLDMEVFFELRIVLAHILRSVGIIVIISYSVPVFLAVIVPLLGLFYLAQQFYIRTSCQLRRITSKNRSPLYAHFSETLSGTNVIRAYQAQGRFIHESEAKTDYFQRAVYASNAVNKWMQVRMDMLSYVIIGSSVIFAVSSRDEMSAGLVGLTITYALSDPMLFAGSLRLNLDPFQEKTDAELWTALEHAHLKAFVEESPQGLEHEVGEGGQNLSVGQRQLVCLARTLLRKTKILILDEATAAVDVQTDGFIQRTIREEFSNCTILTIAHRLNTIIDYDRVLVLDMGQIAESGPPAELLADPTSVFFSMAKNAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSB8</accession>
    <name>A0ABM1VSB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 106B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101848328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM106 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825310.1">
        <property type="nucleotide sequence ID" value="XM_035969417.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848328"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009790">
        <property type="entry name" value="TMEM106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048509">
        <property type="entry name" value="TMEM106_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048511">
        <property type="entry name" value="TMEM106_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07092">
        <property type="entry name" value="TMEM106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21002">
        <property type="entry name" value="TMEM106_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 C-terminal" evidence="7">
        <location>
            <begin position="134"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035825310.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30574" checksum="072925D4D425982E" modified="2025-10-08" version="1">MSVSSETGQRSGSRLASSEVEVEYIQSAERCLMSTPLLSGARSPIASDGGQFGSLNRETGDLVPCPSCRGQGQVPKAFQSELVALIPMKDKRLKPRRTVMYVVIAVIICAIVAGLLVFFLMPRDITLSSSSPFLLSHHVNINSTANTVTLDVVHQFNLSNCNFVQVTVTGVSLTARYFQSALGNATAYVDNPLEIELKSDATLSVPVQIKLQDAQGTTFVKRCKAPYKWEYEFYLFFSVTVNYTLLTQSNQALLTTFQQTSCKPTTTSMDIQGMASLPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VU04</accession>
    <name>A0ABM1VU04_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium-activated chloride channel regulator 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825896.1">
        <property type="nucleotide sequence ID" value="XM_035970003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853791"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825896.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="52819" checksum="C5FAEBE1423662C9" modified="2025-10-08" version="1">MVKRELPMYGTFYIDSTVGKETSLTFSYSEYIEVRVQGPDAMYTADKYKDYFRYDEGSKVLKVILPGESSTGMWSYHVSTNATKSQITVSVQSKTRKKGIDVLQVTSWIPEQGEVEFSPKQKFGVYAEVLRGKAPVLDAQVMASIERPQSSPVDLVLYDNGVGADIIKGDGVYAANIMAKDLMGDGRYNIKVKVIGEEGKTKVVVGGTGTSSRALERQTAGQLINTETSRVENFQRVTSAGEFRLRGFSTLNKEKEQDEMPPSRITDLRVIIFDYDNFTATLQWTAVGDDMERGTASRYFIHTSGDFDQLLLDRSKATLLSKEQVLNGTLSYPQPAGVTEEIIVHLHAIRDNRTVFLSVVAIDEAGNEGDTSNLVSLSPAQETAVPRVPMSTISLKTYLAIALPLALALFVFVALGVGLLVARAKKMKSKNIEQVQNIGALSHSTHSLDMSNMNYMFEGEYRKRLQEDPDTWSRGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVG2</accession>
    <name>A0ABM1VVG2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable low-specificity L-threonine aldolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826404.1">
        <property type="nucleotide sequence ID" value="XM_035970511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852330"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="4">
        <location>
            <begin position="47"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035826404.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="44147" checksum="3BF2542467ED3B5A" modified="2025-10-08" version="1">MRSLSLLTCARNLVSNNLLRNELKGKTLTLARIHHRGLATSSVSIVDLRSDTLTKPTPKMREAMKNAVVGDDCYGEDPTVNKLQDVCASMLGKEASLFVPTCTMANITAVIVHASGGFSEILLGEDSHMFLYEVAGMARFAGVQGRCVSTLPNGTLDLAELEGKIRPLDDVHQPWTKLICLENTHNKCGGRVVSLDYIQKVKEIARKNNLSFHLDGARLFNASTALKVPVSEVAQHFDTVSIAFSKGLCCPSGSILAGSKEFIAMARRARKALGGGMRQAGVVAAPMLVALEEMVDLLADDHDRAARIAQGLTAMGDNPVCSIAMDGVQSNIVMIDMKGKVSSEQFAQRMEQVSDREKTALGEAVSVRMLPFTATTVRYVTHHDVSDEDVDKAVRKIQYVIEELSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVV6</accession>
    <name>A0ABM1VVV6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose-phosphate pyrophosphokinase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826548.1">
        <property type="nucleotide sequence ID" value="XM_035970655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845407"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF45">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="2">
        <location>
            <begin position="282"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826548.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="42693" checksum="6BAB47827EA300DD" modified="2025-10-08" version="1">MASNGDVVLLYAHPSTQNLARQIAEGCCNGTGVSDTSGPSLGASLSGDVQKKRVVNDGILAAGSKHKMERSFSAVTTARHVEFRDTIQWKKFADGFPNLFIEDVKYMAGKDVIFIGSFHSPEVVFEQLSVLYSFPRYLARSFHFILPYFPTGTMERVDQEGQIATAKTAHAVLVGGWRAQETLATLISNIPLSARGPAQIIIYDIHVLQERFYFSDNVIPRLETAIPLLQRAISEQPDPDSIMIAFPDDGAYKRFHQFFPDDSKLIVCVKKREGKNRVVTIKDGHPKGKRVIIVDDLVQSGGTLRECGKALLQAGATSLSAYVTHAVFPNQSWRKFTEADPKFENFWITNSIPHAEEIAKHPPFRLLSLSDIIAENLLGFDLMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVY6</accession>
    <name>A0ABM1VVY6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC101851510</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035826578.1">
        <property type="nucleotide sequence ID" value="XM_035970685.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851510"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01379">
        <property type="entry name" value="MYSc_Myo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036083">
        <property type="entry name" value="MYSc_Myo3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF3">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 21" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 21" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13 21" id="KW-0518">Myosin</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0844">Vision</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="24"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="25">
        <location>
            <begin position="339"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="883"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="21">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1258"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1396"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1436"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1557"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="884"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1282"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1454"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1582"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1593"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1604"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="432"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_035826578.1"/>
        </source>
    </evidence>
    <sequence length="1675" mass="190138" checksum="85E4A25DE9950941" modified="2025-10-08" version="1">MFKLYSYTSDVLDFSKLEDPSETWALGETIGEGTYGAVYMGTHKATGEQVAIKVMENVSEVIEEIEEEYLVLRDLGDHANMPRFHGIYLRRNPHHEDQVWIVMELCGAGSVTELARHLLNQEQRMEPDLIAHIMKETLKVLDHLHYHQVIHRDVKGHNILITGQGQIKMVDFGVSGHLDFPNGRMKTHVGTPYWMAPEVIACEQQLEYSYDVRCDVWSLGITAIELADGKPPLGDLDPRRALFKIPRSPAPTLRHTDQWPAELNDFIAQCLVKDFEQRPDVPDLLKHPFIQKVPEDTSQLRKRLVSLTANMERKISEPEVTTKHGQLKPNRKSRREGPPTADNLTQLEVLDEETIVQQLELRYSADEIYTYIGDILLAVNPFVSLPIYTDEYIRRYMHAVKADNPPHIYAVADQAYQMMMHNKKHQCIVISGESGAGKTESANLLVQQLTQLGKAPNRTLEEKILQVNPLMEAFGNAKTVINDNSSRFGKYLEMFFTASSGTVIGAKITEYLLEKSRVINQAPGEQNFHIFYYVHDGLMSSDRQEEYHLKPRTLYKYIAEYTEKATDVSAVSINRVKFRAIEHCFDIIGFRHEDVTSVYAILAAILHTGNIEFVPKDSGYGGEASAVSNTDLITTVSQLLGLDFTDLLECLTTTGMVAKGEVIVRDNSIREACDSRDAMAKALYGRLFSWIVNRISSLLKPGRSQISDDECYVSGLLDIFGFENFKTNSFEQLCINIANEQIQYYFNQHIFAWELEEYKNEGIDAAEVNYVDNRPILDMFLSKPVGLLALLDEESHFPQSTDLTLVEKFQQNIKSPHYCKTKSSNVNFAIDHFAGKVEYDARGLLEKNRDRLPIEILNIMRLSENEVVKALFQTPLTKTGNLASGSLTSSSRSSRVGSPMSTSSSAINISSYNSKSTSSMGGSRIYSLLHTSSSTASSASMTRIQQTVATYFRFSLMDLLNKMVAGTPHFVRCLKPNDVKEPGNFQPARVTTQLRYTGVLETTRIRRQGYSHRIVFSEFLKRYHVLGFRHDEAVSVTGESCQILLERLGMSKWAIGKSKVFLKYYHVEELAQKYEEVCQKIVRVQAYIRMWLARSRFYQLRWKRDKAALMIQRHMRGFVVRRKFTAMNRKRHDAATTIQKMARGQQTRKKYQPILAQRREASVKIQSQVRRFLCRRRYSKMRLVREEEERVRQRQAEEESAQRIQRIFRMYRLKKKTNAIVEEHKTRELSATKIQAFFRMWRQKVVYRKLQRQKKLSQQKAAAQSQQAVSSNENMLERQDSSSKAVRTATSALASAVKDSPSRKKTSATDSPSKKVWERVSLQAVGEARIEQMKKMNDVKAIMPDRDALYYDSVSGDEMMVTGNNPPEVVLNGADIDTDYPDIDEEVMSFMHTHIHNSQKMESKTSSEPSTEDTARTQLSRLLLAKKVAEAFMANKPGPEAENDNENVAPPTEPQQAPSSDSMSGVSWDAPLLTAKENALAPDDYNENISGRISRHSEYSIEADLQTERDDLAEEDNAAELAKRLEEELTGSILALWQQRLTQSSSFEGDIEIEYASESETGSAGPPSPTPESSRPTVFPATRTSYAYTTTDNADRMLRRDRNGNSMGPGSSNSNPNAPVRLPISASADSNSALEEIRARLRKTKFDYSSDSRQRISDATPQTDYRAVLKKKGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW51</accession>
    <name>A0ABM1VW51_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein rolling stone isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826643.1">
        <property type="nucleotide sequence ID" value="XM_035970750.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854464"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049352">
        <property type="entry name" value="Rost"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21534">
        <property type="entry name" value="Rost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826643.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33657" checksum="C2D31DE4B6211E11" modified="2025-10-08" version="1">MSCLRQYLPGVSIDSFFLVHDNEMDFLSFKWLPQPGLYAIYATVCCVYTLAMTVYSGFDSPYGAKILIWMTYWGYYSLTLRFTVTAVNAWRNVVWLKYESEGEGNVFDESAPSPESEREESGERRGSSSREMHHLPPGLALQWLLQNISNSVSLLVTVLFWALVYTGVHQTYMSINSHAINSLLVLADVMLSAAPIHMLHFHMPLVYLMIYIAFTLIYWAGNGTNHRGEPYIYSVLDYSGKPKVAIVVIVCVALIIVPLTQVLLCGLRRLREKIHAKLRLWKDLENPTRLYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX60</accession>
    <name>A0ABM1VX60_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827002.1">
        <property type="nucleotide sequence ID" value="XM_035971109.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478146"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827002.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="45178" checksum="0C67936DC0700901" modified="2025-10-08" version="1">MSAVRLSLEREPGHASRHPAPVDPLKSLGVSALKTLQPDGNFFSDCTSPRTPLDSESNAIRMRSNSSKIQTDPQKSVDWKQPESGHRVAGSDVGSFPLNMNPTQMAIHTETEKLARICGTFPERSRVSLVNFPYGEVSPNCVSSPRESLTPSRRGRGRKILGARAPPCKDTQVATQTQTQTMNPESQAPDSLLLIKQAVQNFYGGGAAAAAETLPDSSHHDHTPLYVADLKKTLPPVPEVKRSPVSGGPEVKVSPISGVSAVKMSPVSGVSKVKMPPVSGGSDAKISSISDFGASGFSKSLTEPRYNVKTSEEPRDMRNTNKFTQMGASAATGTSTYPKTPDHMTRKMAPSGSGNPSPASNACTCVRSSKLILCQTCGETMHGRVRRVCPVHPSQIFLMDFEFCGKCKCKNLREICSTPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXM4</accession>
    <name>A0ABM1VXM4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0746 protein DDB_G0281095-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827167.1">
        <property type="nucleotide sequence ID" value="XM_035971274.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849143"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827167.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="45691" checksum="9086B75E14D95854" modified="2025-10-08" version="1">MHFSNYGGCPKFSQGHLPDVLLAYGLWILQASRERRFDVVRYCFLDIFSEYLSDSTPAVNTQGHVKSPRLTRVQRPFDSYKLPPDFRPDRSTILKHARPSNEQLREELKLQCGFLGLGQQQQQRQQQQQRQQQQQQQHQQQQHKVQQQQQVNTSHLEQEHQNQAHWLQAHAEQAQKYASLSNEQLISEIKKLKCSLNTRRPFLGLGLQQQQQQQQQQQQQQQQQQQQQQQQQRQQTVQQQQQVNQSHQDQEHWLQVHREQAQRLQVHGEQAQRQQVHGEQAQRLQVHLEQAQRLQVHGEQAHGLQVHLEQAQRLQDTRNKHKDCKNTRNKHRGYKYNGYRHSGNKHKGHKYTRNKHNGHKYTSYKYTGNKHTRNKHRGYKYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYW5</accession>
    <name>A0ABM1VYW5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC106012760</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106012760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035827608.1">
        <property type="nucleotide sequence ID" value="XM_035971715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012760"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="226"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035827608.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61145" checksum="0E775AE4425DCA57" modified="2025-10-08" version="1">MCRGEPLTDTGKRLQLLKILSLTLLPILGLWAFTVYSLSDSIQGKSDIEQTQYAVEFSVEIGMFLDRIQRERDMSVLYLSILGPETKTFLMNEYLLTDQALDHLSDWPVRNDIQPIFQSRKEFKKFLNEHRQNLDPSNYDIYVEMEFYSFLIERFIEWMYGAIKESNMASIWKILVAYQKIVTVMEHIGIERALGTVRNYYLWVLQSILLFSCIYKKKNFLQKPKNLSFYALNRGNPVSLSQECSPLEIVNLLNNLYTEIDQRLDHHDVYKVEAINDSYMVASGLPTRIGNRHSAEVANLALDLLSMVVDNRFSTPLDRMIQLRIGMNTGPCMAGIVGTIMPRYCLFGDAVNTASRMKSYGSGESQDSSLSTLIVQQCYNSRKFSMFALHGSKNTQVSLASQLGHSDKTEGEAGGLSTMRSPATRPKSDNLSRSSIHENVVGGPGGGGGTGGPGEVGGKKSLHRFFIHPENMTLHTVSEVAEKTGGKEGSKDVKGVLESAEGDQDADDEGEHESREGDNDTGSHNRATGKADESERPESVATPIKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZW2</accession>
    <name>A0ABM1VZW2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance-associated protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106012934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035827955.1">
        <property type="nucleotide sequence ID" value="XM_035972062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012934"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827955.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20378" checksum="6E50B30524CF9554" modified="2025-10-08" version="1">MSPINVLVDQCSGQWNRVLAINVSMRVAPGQLVAVIGEVGSGKSSLLSALLGEMHRLAGHCSVNSSVAYVPQVAWIQNSTLRANILFGRQFKRNFYNRVIRACALVLDLEILPAYDHTEIGEKGVNLSGGQKQRVSLARAVYSQADIFLLDDPLSAVDCHVGRQLFDDVIGPQGLLKHKVSYYGLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W189</accession>
    <name>A0ABM1W189_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase DCST1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101848551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828432.1">
        <property type="nucleotide sequence ID" value="XM_035972539.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848551"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058842">
        <property type="entry name" value="DCST1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF17">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DCST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26037">
        <property type="entry name" value="zf-RING_DCST1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="725"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="916"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="8">
        <location>
            <begin position="858"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase DCST1-like C-terminal" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1146"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="633"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035828432.1"/>
        </source>
    </evidence>
    <sequence length="1168" mass="131460" checksum="A2888E7E3DF9A80C" modified="2025-10-08" version="1">MAELTYEDETIGMKGVSHVIEDKTTDKDGRCSETEQGNTRRFKYYEDVSTSFSPTFSPLRHPHIYHQEKNEQQFSAHGVDATSTPGQRFEPMSLTCAARGDFSHLSGHRRESNPIDTAQNLSHRDSDKDIPHMNYCFAEHGQCTRPIVFPGKPDMKSGKGRQSLSPHGRSHHFSRVLYKNTTAGTLERRQTESKMADQLALQESITVQQASCFHEESLFKPVLSNSLSSQFKQDSNTAFSCLLSKATEENMNHNRVSLEGGDYRLCAAAPVTSQPDTNVSDAMTEQGSPPYRDSVGESNYSSSNSSNSSNNNNSSNNGSGSSSSDNNRNNDSYGISRDDDDDDDDSGGGGRVEGKEKDESDTPQFSFFDEAQEYESHTDTQEDERCRGSHCNNNSNSNNRSTSNDDNNNTHSTDSGSSTTSTFPPTPTPPSSSSSSFGTHSPSDNDNDNDNDNNIISKTSQKNKKKKRRRGLLANLLKSAPDEHRLLKITLWFPVGVVIALALHFLVIDKLQLDKLTKLLVGAGLGLLLALTFALSLQMRCVTCLVVPTFVGKAGRSYIAAFAIIYLIDGPIGNIVDNSKEVVRSLTCTSALLANHSREKWKLRLHPVEGALGDLQKDGFLLSRASRLIEKAFTPLKKEIEKNERENEELEREIVQAEEKSGSQEGVVAKVEQQHREDQEEADPGKRVEKEWSKKLALRCEDTFSKGVLRCQEKMSQLHGRCMDTLWIIGYLLCWPLQITIFCQIIKLLPGAVGMDCDSADVLSPGFGDTYLAADETIDDLEKGFQVRMQYRVVGSAEVLDYSPVEELRQATVHEVDQKSRLVGYFFSFISHVLAFTFLLIFKSAYEYNKKYLSDLSHDNIYITGYFRHIDARRHAQSKRTLLPLKRFEKKDVIFPGSVGLTKSEKRKVGKGTLKLLLRVVVSAVVCYMDALLFQVLNIISRHSRVEYHQEGEHIIDIQVSGTGFMSALVRGFLQKFNSKHTLNQVTTNHACLPNPSKTDDVIVGFIFATYVMVWLFIYFESFGLRMRRVIASFFYRKREKKRVLHLYNEMYRKRLGYLRHMRHRVRKKLRARELKMNVGAIVALQRQFPILCRCLSVCKSAKKTCIICDERERRGFHSCPTSGCGVAYCPECWRDVKKKCYACGEDSEAESDASDLSTLTEDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1R0</accession>
    <name>A0ABM1W1R0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118478670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828603.1">
        <property type="nucleotide sequence ID" value="XM_035972710.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478670"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828603.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="49232" checksum="5876502800108560" modified="2025-10-08" version="1">MQGIVACALFRSLDSYRRRNISSKLSAKSTKKTNEKGVKLTPGEYEYDVTVELLPGNSPEETTQAVIPKKTSSDNNLVTSLYEEHFSKTSSKREKFITNPARSYLMRDNQKGSSMTISDFCGHRTEEQCHCVYRILPQGASDDVKQGQGDLVASSVLPGSCSGDLTPCRRQRSQTVNDAMADFGRATRHKNHPFPHGAVQRKAESLEWLRNLNITPVLIASTISISDGNSHHSSEGKDHNHHQSYPCQNDTTNSKLFTNSQAHPNKRISKIPQILKTVIKSIFDFSVLKDWQCFSNLTAYVLARCGMFIAIYLPAYAVKSGISESRAALLVTIYGVLDMFSRICFGYIGDFHLIRPKYIISICSALMAMFCCLGELFDTFETLVFFSVMLGILGTVTLSLNTNNIVDMVGIERLGALLSLGSLLLSLSLSMQFPLLGESLSSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W414</accession>
    <name>A0ABM1W414_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101861413</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829407.1">
        <property type="nucleotide sequence ID" value="XM_035973514.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861413"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6 8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045113832" description="Delta-like protein" evidence="13">
        <location>
            <begin position="21"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1058"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="15">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="256"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="294"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="408"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="446"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="533"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="571"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="609"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="647"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="685"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="723"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="761"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="815"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1122"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1210"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1303"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1242"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1303"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1349"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1402"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035829407.1"/>
        </source>
    </evidence>
    <sequence length="1450" mass="157954" checksum="2E1D7395D099FD7C" modified="2025-10-08" version="1">MLWTVVLFCLVGGLVEVTEGSAFLSVKFLTFRNWRGLGSNGHCCDGKWGVCFSPCDHSFNVCVDQVDGPHNNYYHCTYGRKYSGEISNANYISFRSRVGRLNNPFSYELDHWPGEVLLKIDINDVDPDHNSNDDVDFFNRVVSLRPTRSTRGTIIELRQRVTLTLELRVFCSRDHYGGNCSVHCKAQNSNIHGHYYCDGNTGAKICNPGWEGPNCNKNINDCRGVLCQNGGTCNDRLNSFTCTCAAGFEGRLCEHDVNECLRHDLCVHGSCVNSPGSFSCDCHTGYSGRKCDIDIDDCASQPCLNGAHCIDGVDMVDCICQPGYQGELCADDVDECLMDICSNNGTCINSPGSYRCECTTEYQGPHCTQDVDECGSNPCQNGSSCVNLHGSFRCDCVRGFEGELCADDVDECLMDICSNNGTCINSPGSYRCECTTEYQGPHCTQDVDECGSNACQNGASCVNLHGSFRCDCDQGFEGPLCATDINECDDDYNNNNNNTNDNDYNNNNNNTNDNDNDNNNNNNNNNTNDDNNNNNNNNATLCQNGGLCENTNGSYLCTCAVGFQGRHCDVDVDECEADVCVNATNCTNTHGGFHCSCGGGFTGQLCDTNIDECLLDVCQNGGNCSDTIGSFLCACPDYWEGPRCEQNVDECERSPCYNGSVCVDIEQGFRCDCPQGMWGDLCGEDIDECARDVCRNGANCTNTFGSFVCSCERGWSGEVCDVDEDECASEICEHQAVCVNMAGGYSCECPRNWTGDRCQLDVDECRGEDVPCRNNATCVNLIGSFHCECLDGWQGYVCGEDVDECREVARVCEENSAGNNSTGNNSAGNNSTGNNSTGNNSTGNNSSLSAGTNETSLVTSHFVCVNTQPGYKCVCESGWTGDRCDVDIDECSTPTDHDAWNNTSMAPGVPGSHTEVVTSYDEDENKSVHLVPTEESAEPKMSVPFYLACRLGPNDFQTVDREFVKLLSDVTGLAPDVFSVSYKFEFTHLEDGQVLTSVHPTVLLGGVLMSTSEVTDLLRGVNVTAQVNRRFQCPLYLHAVPAKIGYSQQPSESSGFSWYPYVIAGVACCLIAVLIVFLVVWRRRHRGCSGGKYFVKDDGNRSTFYSDTTCVLSQPGELGHGMGQGAPGVRENPLYEPEDNGLSITNPMYEPADEQIQQPGVQDPAVRSNNPDSPGEPPQETTLGTFSGEYCSADVGWTPVCQAGHVSEAGQGTAVGGTDNNDVSSPNTSTDEPAAASSRRLPPSPTRHTPPPPDHWYASIDDRVLTDDVTTPQPPGHYELEETPPTHINNPLDLTQLLHVSAPSQQSHCKQFNQTTTELPAEQARSRPSVNASLAQEKLPPKSLSRKAATKENSDTKPKEKRDRFEEPLETILGCLFEPPPTTANPSDADRPGKRELPPGSSRETVNTQTTSEPRYKVPPSPHRAQPRRDTADPFPHLPYIDDLSLPQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4I5</accession>
    <name>A0ABM1W4I5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-rich adhesin for platelets-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118479067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829578.1">
        <property type="nucleotide sequence ID" value="XM_035973685.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118479067"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829578.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="63471" checksum="FCAB90570487B4EB" modified="2025-10-08" version="1">MSSSDSTPQPMSSSDSTAQPMSSSDSTYQPMSSSDSTLPPMSSSDSTYLSMSSSDSTYQPMSSSDSTPQQMSSTDSTPPQTSSSYPTPQPMLSSDSTLQPMSSSDSTYQPMSSSDSTPLQMSSSDSTPLQMSSSDSTLLQMSSTDSTHQSMSSSDSTYQSMFSSDSTPQQISSSDSTPQPMSSSDSTYQPMSSSDSTPLQVSSSDSTSQPMSSSDSTPQPMSSSDSTPLQMSSSDSTPQPMSSSDSTAQQMSSSDSTLPQMSSSDFTPLQMSSSDSTSQPMSSSVSTPLQMSSSDSTYQPMLSSDSTPQPMSPSDSTPLQMSSSDSTPQPMSSSDSTAQPMLFSNSTLPPMSSSDSTPLQMSSSDSTPQQMSSTDSTPQQMSSSYSTPQPMSSSDSTPQPMTSSDSTYQPMSSSDPTPLQMSSSDSTSLPMSSSDSTYQPLSSNDSTYQPVSPTDSTSHSMSSTDSTPLQMSSSDSTQLQMSSSDSTPQPMSSSDSTYQPMSSSDPTPLQMSSSDSTSLPMSSSDSTYQPLSSNDSTYQPVSPTDSTSHSMSSTDSTPLQMSSSDSTQLQMSSSDSTPQPMSSSDSTYQPMSSSDPTPLQMSSTDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C5H674</accession>
    <name>C5H674_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 13">Chemosensory receptor C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100533255</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2009" name="BMC Biol." volume="7" first="28" last="28">
            <title>Candidate chemoreceptor subfamilies differentially expressed in the chemosensory organs of the mollusc Aplysia.</title>
            <authorList>
                <person name="Cummins S.F."/>
                <person name="Erpenbeck D."/>
                <person name="Zou Z."/>
                <person name="Claudianos C."/>
                <person name="Moroz L.L."/>
                <person name="Nagle G.T."/>
                <person name="Degnan B.M."/>
            </authorList>
            <dbReference type="PubMed" id="19493360"/>
            <dbReference type="DOI" id="10.1186/1741-7007-7-28"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EU808013">
        <property type="protein sequence ID" value="ACH72065.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191495.1">
        <property type="nucleotide sequence ID" value="NM_001204566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C5H674"/>
    <dbReference type="GeneID" id="100533255"/>
    <dbReference type="OrthoDB" id="6102892at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACH72065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="NP_001191495.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="44629" checksum="E0AA8E9714DD65B0" modified="2009-07-28" version="1">MSLVNETERELKGSHNISEHGGLIDDQTLRIFLLVFTFVTLGLSLLGSAFNCINITVFLTLGAKDCVSVCLLSLAVSDFTCLFLGAVCGVCDILDAYGSADFYVDPRGLYYQVIFISSMSYDISTYITAFISLERCLCVALPFRFKELFTFKRAVLAMATIFCLTFCCYLPHYVTSGLRVQWDPRTNTTRVLLWSSKDMPAITAFLDLWNHLILAVTSVVIVIVCTHIMVTGLKKSSQFQRRGAARPSEPDGPNNFKTSNEVGEGEENVLRDPDSRRDNNISTPYCPTNVEKESSNKIKVEKSPQTLSAKNRRVVKMVSTLAIVSILCNTSRLLFVVALRAEPDINFGHRYHNLYMVILVLAYIFQVINAPVNIFIYLKLNPSYRKTFSQIFGIGQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAR3</accession>
    <name>A0ABM0JAR3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutathione S-transferase theta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089374.1">
        <property type="nucleotide sequence ID" value="XM_005089317.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848706"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03183">
        <property type="entry name" value="GST_C_Theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03050">
        <property type="entry name" value="GST_N_Theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040077">
        <property type="entry name" value="GST_C_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040075">
        <property type="entry name" value="GST_N_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051369">
        <property type="entry name" value="GST_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917:SF8">
        <property type="entry name" value="GH16740P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="89"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089374.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="27102" checksum="2E090864968CE38E" modified="2025-10-08" version="1">MPLKYYYDLLSQPSRAVYLFLTYNKVPFEAKPVALRKNEHYSAEFKKINPFSLVPAIDDDGFCLTESTAIAKYVIQKFNLPDHWFPQKDIKKQARVEEYLHWHHFNTRALCANLFRNLLILPRATGKKADPEDIEKQRQRILKIVIPAFENYFLKDRPYLAGNEISLADLFGSAELLQLKACNEEYLYEQSPIVKAWLERVRKETNPYFDESNKLIYRTGENFQNIISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC47</accession>
    <name>A0ABM0JC47_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0235 protein C15orf40 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090262.1">
        <property type="nucleotide sequence ID" value="XM_005090205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861926"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090262.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13040" checksum="52CB3C1BD3D1BC93" modified="2025-10-08" version="1">MLWHFTKKAAWMRQASDKMPKSASGKAKAKLGGKSAVATSPEDAKSTSPVNSRPDGSVEIKILAKPGSKHNSITGLSEEGVGVQIAAPPVDGEANTELVKYLTKLLAVRKSDLTLDKVIINDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCE9</accession>
    <name>A0ABM0JCE9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101850223</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090479.1">
        <property type="nucleotide sequence ID" value="XM_005090422.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850223"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045783481" evidence="5">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="6">
        <location>
            <begin position="78"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005090479.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21819" checksum="AF3A71F3A0C1D38B" modified="2025-10-08" version="1">MTGTEKFLVLALLLSTTSSMLYSRQRHRWSSPLYRSSYTPSSSSSPSPSLLRIRQRLNAIKHRPPLGSKYQNRLRNICRVEAVLLRLQPPLSYAETCDATLVHTFGCRGGCSSYSSVDPRNATNILHSCSCCQPLRFMMSIAELPCKNGQHIRVPVKKALRCTCRPCYSDNSAKDTVKLRDLLTRAAVNTPFPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCL1</accession>
    <name>A0ABM0JCL1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein LOC101861014</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC101861014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090599.1">
        <property type="nucleotide sequence ID" value="XM_005090542.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090600.1">
        <property type="nucleotide sequence ID" value="XM_005090543.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861014"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005090599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090600.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41597" checksum="138D8357B01C8BF1" modified="2025-10-08" version="1">MSALDKVFTELNRKELKEKGYTVVRGVFPREVCDEYQGAYRDWLNGFPEGTWPQTKHSLIQKYSVGHMSTSWDIRLKCYPVFSQLWKTEKLLSSIDAIAVGRPPEENEEIFWAPGQSWLHVDQPAYRLGLHAYQGAVYLEDCEEEDWTFEVVEGSHKHFDDLHNRIGQKRCTKLTPEDLEWLTEKGCRLTRVPCPKGGMVLWDSRLLHANARPIEGRRNPGRWRWVVFVCMTPAVWAKKLDLKLKKQAYENLQLTCHWPSRGVFIFSSKLEEGMTEDPNPLNTLPEIATRDTAKRLMGLLPYEGDNNKSVHTLEFDAEKFKDQMTDNDRKLLEENDEDCELPPPYEPFSHLVIPTSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCW7</accession>
    <name>A0ABM0JCW7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-coenzyme A amino acid N-acyltransferase 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101845974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090805.1">
        <property type="nucleotide sequence ID" value="XM_005090748.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845974"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="3">
        <location>
            <begin position="249"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005090805.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="49940" checksum="00638B514F51C8B6" modified="2025-10-08" version="1">MLRSACSRRLYTLARHVVSGNGQQVYFSSDVNAGQSIRVEPRVALYDDKVDIALSGFSSHEKVTVHGQSVNGEKKILFGSCGQYIADENGFVDVTKQPSHGGTYTGVEPMGIVWSLQPAPGQPQQTRMAINFTNRPGLITLNTYAGHLDLTDIYGESGIQPSSLASIEIERWFRHEDVTRIEIEEGNVRGALFLPPGDGPFQGVIDMFGSSGGLIEYRAALLASRGFAALSLPYFKYKDLPANLLDQGFEYFEEAVNWFSKHPKIYQGGIGVIGVSKGAEYVLCMSAYCPQVTAAVSINGLFNMCIGDLKYKGEVLLKGSEIDLRDEYFTDDGLILTDAYPTRGDLIPIWKGKAKHLMLVSMDDGQVNPESYQVLYDACPEEKKKDIEIVRYPGAGHLLEPPYNALCRASVNRVFGVVMYWGGRPKEHAHAQEDSWQKTLEFLRENIPKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD28</accession>
    <name>A0ABM0JD28_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101848169</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090908.2">
        <property type="nucleotide sequence ID" value="XM_005090851.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848169"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="10"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005090908.2"/>
        </source>
    </evidence>
    <sequence length="559" mass="62304" checksum="05D3C4B3388E62F4" modified="2025-10-08" version="1">MAKSNSSLPFLEVVVKEDPPFVFSSTDSSGKVSLSGLSIDLLERVANLAGFTYNVSLTNHASYGHKINGKWTGLISELESNAQIAIGPFTDSPSYAELSKPFMNSGVNFVIKNPQPSGQPQMKRDIGLLLEPFAAEVWVMILLAFVAVSLALFLIGRFSPYEWARVAKEKDVRHARTSFGLKNSFLFAASTLGWQGYREAPKSTSGRILMCMWFFFTVFVLLSYTACLCSILTIRSHNSVQPVEDKRYVPFKDAADILDKKNVKVGAMKYSYVYKTLQDSKSSGDLSKLFNYIENSQDWIQNENEGIQRVKDSGGKYALLIGSVKADYIESRHCDLVTYGGLTDKYFRYTFAISSRSLLTTKINWALLRLKEDGQLHMMQMEYFIKGQKCPANDKSKLVPVSEKSAVPFASTYSRLDMRDMAIAFLFLFLGVLAAGAALGAEIFYRRWLLSKRDPDKKVREPLNTESGISRAPKATPPPPPIYKVNKLQENDKNKKEENVAKVAQSSDVEKGNDIELEVVEDKPYAAKVELESTDEINDAGTKPELPSVDTTAGVKENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD39</accession>
    <name>A0ABM0JD39_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AP-3 complex subunit mu-1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101856555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090946.2">
        <property type="nucleotide sequence ID" value="XM_005090889.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856555"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="213"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005090946.2"/>
        </source>
    </evidence>
    <sequence length="459" mass="51811" checksum="54DF2FBAE252A4E3" modified="2025-10-08" version="1">MSKNGKLSVNSLESTRHPPNTYFRSLVDVVNITISKMIHSLFIINNTGDVFMEKHWKSVVNKSICDYFFEAQGKVTNPEDVPPVIATPHHYLINIYRNSLYFVAVVTTEVPPLFVVEFLHRIFDMFEDYFTECSETNLKDHFVIVYELLDEMLDNGFPLAVESNVLKELIKPPNFLRSITDTVTGKSTGVGATLPTGQLSNIPWRRTGVKYTNNEAYFDVIEEIDAIIDKSGSTVIAEIQGYIDCLIKLSGMPDLTLSFVNPRLLDDVSFHPCVRFKRWETEKILSFVPPDGHFRMMSYHIGANNMVAIPVYLRHNISFREGSGGRFDVTIGPKQTMGKTVENVVLEVPFPKSVLNVTLTANQGKNSFDPVSKLMTWDVGKIDTAKLPNIKGTITLQTGVPVPESNPTITVMFTINTLAVSGLKVNRLDMYGEEMKQRKYKPFKGVKYITRAGKFQVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEA3</accession>
    <name>A0ABM0JEA3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase Hakai</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101854232</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Hakai family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005091732.1">
        <property type="nucleotide sequence ID" value="XM_005091675.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854232"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16508">
        <property type="entry name" value="RING-HC_HAKAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040380">
        <property type="entry name" value="HAKAI-like_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040383">
        <property type="entry name" value="HAKAI/CBLL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041042">
        <property type="entry name" value="Znf_Hakai"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13480:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HAKAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13480">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HAKAI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18408">
        <property type="entry name" value="zf_Hakai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="135"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="429"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="517"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="594"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="743"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="594"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005091732.1"/>
        </source>
    </evidence>
    <sequence length="799" mass="85180" checksum="C285EF927CC637BE" modified="2025-10-08" version="1">MLELDTEFAEEEVVENPTLKAAYNLAPLHQNQPLRWDHKVDLLGEKIYDKVIHLCELCELPILVYGRMLPCKHIFCFDCARKCEKTCKRCGARVQKVEKSALGTVFVCTHGAPKHNTKGCRRTYLSQRDLQSHIAHRHMPKPESKSSSQPATMTSQASLQLPLTQQQAAQQQATQQPVGNPALSVNSLGLPPHLAPPLQVPGGHSAGGGLNLSSSSSHSGPVGQQLSPAPPLIPGLGDLRQVASSVAGSSSSAGHGGSPLVPPAPSPGSMAPSMLPFGSPGVQGGSEPSIYRPLDMVPLSQQHQHKHQLQQQQLELQQQQMQHHQQHQQGMGLASPHMQPGHGGAMQMGQGGIMHQGHGSMQQGLEMQPGRNMPQAHNVQQGQNMQQAHNMPGHGMQQGHNMPQGHNMQQGHNMPRGHGMQQGLNMPQGGHGMPQGHNVPQGGHGMQQRHGGLQGLDGSGGHNLPQSRRDMQTGHGPMSHGHSPMSSGQNAMHQGHGNMPLYNQGRISPGMMQQMNNQRIPSPTSQLLPGSGGHQQLSPLSGGSKNVDNFNSSQGNAGPGLQNPQARTNVNLITVPIQDEGQYRPLPYVNPSQGGSASFTQTRPKMQNPSQQNFGQSNISSSGMFPNANSPQQMAGRDNHNLGGGGGGGGGGGNNAQNMNFNKGASNAQGALLMTPHSNMGANMPNNMPNNMPNNMPNNMPNNMPNNMPNNMPNNMPNNMPNNMPRALAGMVQAFNFAARSQGAGLIPTPGNSGQGGSPRFNPTNRWPSPRGIQPRMTQGQQRPRGGGGDGQFQPNYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF78</accession>
    <name>A0ABM0JF78_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Beta-lactamase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101850142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092331.1">
        <property type="nucleotide sequence ID" value="XM_005092274.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824065.1">
        <property type="nucleotide sequence ID" value="XM_035968172.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850142"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="32"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824065.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48214" checksum="10BCC485C6F84449" modified="2025-10-08" version="1">MTSKLRFPPPKGFVAPGFEDVLNTFRDSFSKGIDKGATFAAFYRGKPVVHIWGGLADEEVKRPWKEHTMGFLHSTTKFAAAITIAHMIDRGLLRYDQKISSIWPEFAQNGKEDITLETFMSLRSGLPVLSENFEISWLRDDPRRLCEVLEKQEPLWPPGEAHGYHVLTIGLYLDQIVRRVDRKKRSLSQYFQEEIAEPFGIELYIGLPKPLHHRVARLTPRPIDRQNMELKVKQFKGDPVINQLSLTQPKDWFSTRRLNDPDFMELPCPSSHGVGTALAVAKLTGIMANGGEHDGKRLLSPESIARMQEPLSYGTDKTLSGSEIYSRGTILQPVVEGTKSWYMFGHSGFGDQNSAADPHYKVGWAYLTNYADPNVSMTNENKWRPLVESLFSCVHRLEGVQCERKMLTSFEELQREKSLTNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFR6</accession>
    <name>A0ABM0JFR6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">methylcytosine dioxygenase</fullName>
            <ecNumber evidence="11">1.14.11.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101846562</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>a 5-formyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53832"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="Rhea" id="RHEA-COMP:13657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="ChEBI" id="CHEBI:137732"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>a 5-hydroxymethyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-formyl-2'-deoxycytidine in DNA + succinate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:53828"/>
            <dbReference type="Rhea" id="RHEA-COMP:13315"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:136731"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TET family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.80" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005092662.1">
        <property type="nucleotide sequence ID" value="XM_005092605.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846562"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040175">
        <property type="entry name" value="TET1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046942">
        <property type="entry name" value="TET_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23358">
        <property type="entry name" value="METHYLCYTOSINE DIOXYGENASE TET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23358:SF6">
        <property type="entry name" value="METHYLCYTOSINE DIOXYGENASE TET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01333">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Methylcytosine dioxygenase TET1-3 oxygenase" evidence="15">
        <location>
            <begin position="1528"/>
            <end position="2622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="429"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="880"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1268"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1807"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1857"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2018"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2095"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2209"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2391"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2912"/>
            <end position="2974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3066"/>
            <end position="3097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3166"/>
            <end position="3191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1823"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1857"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1874"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1884"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1907"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2029"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2116"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2155"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2227"/>
            <end position="2236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2237"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2391"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2912"/>
            <end position="2923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2935"/>
            <end position="2973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005092662.1"/>
        </source>
    </evidence>
    <sequence length="3191" mass="348793" checksum="A8FFCBA70F52C114" modified="2025-10-08" version="1">MAEEDGQYGAKVSQASLPPFSSFTPSVGLVPGDVGYRGGRNLQQHDLYGSVAQQAAVTGFQPPGVQSVSQSSGFHSPLSVPSHYQPPVPVNEAAGLSQRPGQLYQEYGGTPALNYNNNNNNGSSLDQSIVHTTGNSSTSFPQQSAVPRASSSVSHAFPYSHHPHPNMLTTQPRFFPHSHRVPASSQQSLLHSEQMMMPNSVNPLPYQIPPNQIEPPYLSTAHQHHHPPPTPRHHFPLSTPPQTQHKFAGAHHHSSEMPAETQQQQHQQQQQQQQQQQQQQQQSRLPPFSLFSAQHVSDNHEQQAYSVPSNINMNPSYPSLGSNGHNPHSIQDHSPSLGASFTYNSYPPHQSHVPHWCSQDNITQLYDQSSKAYRSNVHLGVSQQAQVGQQQYSFQTGLPSPHTNFSQEFQSTSCVPKSKAGPVAQVLVPVKEKKENKKAAPKKKVKSKKNQNLPDVSLQVDCGGTTEENRPQSSSPNPCFSPTFLASLSSKRAPEPPISHPILPSAPVSSSSPQQTAAPPVLLKSDHLKPSVPLSNASSISAENNSNSLDRTAAGVNLTKCPADDDKSFRPVTGSSNVPAQSEQTSSSEAGKCNPGLVLNISQREESVSPFQLSPTFLASLSAKRTDDVQDTDQVPTSAAQLSDVAQTLSWKHPLGCDTNVGAAESPAVPSLCQFPGVPASGSDHLRVSVQSLDKENEVVFRDKSPSPNPISPRFLASLSAKKVPSVVTSQCHTQSIPGSTVPPCPSKQLKSKETTSVATSEATIVFQLNSPKPYVSPPSHLQGPEFQYPTPPMEDDEAKDQFPVSDSFSALSPYPVQKVHQSSKEEVKSSMLSIEETYSLPTPPSSAGPKFANPMEIALSKDAQTNRILEIIAREKEKAANTPLTPAVEPKKKKKKKKSKAQGDEDRGIFIPEGTGSGDCQVPHGLVNGSSLVQSDPLCPGGQPVGNVGTTPAGNMNRPTEFHQSAANCAPYLSQNFPPPVIKQLDKAPEHNLSTSSSTKNPDHFIPFDNHPDQNLKSTQYLLSHPTTNRDNAPLQQCSEMPGFVPPPNSINHVGDVHGHTFPQKVSPIMQARHLNSSKYPQSQEIQAVSPLPRAPVKHEPYAFRDNNFLESSKSVPTQKLNVQDSEVTTLQSLNSRGVGFGHEKVGSQKTIQQILKNGDFLHSSDRKQAEGPSQEPQLFQKQKFDLKFDNGVQDCSGQIFQKNGNICQDRLSMSDLVKKTAMRGEQDFQRGSLKAENLLSGIKYTNAYHAAEPLSLPGHPQNLPFSAVCGNDKRNESSKLSVDGKIPKKKRGRPTRPSGVANPLLGNKKPSPLKHKLDPYQTIPQSSTQNRVQYQVNGNNVKAEDVKVSPDLVERLTNNLVEVADCTCLGPDHVPSESTEGPYYTQLGAAKDIPGIRKILEHRTGVAGSAIRIEKVIFTGKEGKSKEGCPVAKWIIRRSGPLEKYLCIVRKRPGHFCNTAVIIVVIVAWEGVVRQQADDLYDFLINTLPKSGFETDRRCGLNEKKTCACQGVDLLRRGASFSFGCSWSMYYNGCKFARSQSARKFKLKEASLEDGLDQRLQTLATDVAPLYSQLVPDAFRNQTQFESRASDCRLGYKPGRPFSGVTAVVDFCCHSHRDGHNMNNGGTVVVNLTKHRGPGKADDEQFHVLPLYILDQTDEFGSMGAQMNKVQAGSLEVLSQYKTQIRFRSAPYRPCKRNRTLGKKEKTPKKMKIGKSKSFPLEKATDQKMGSTCNGTHPYHHDVSPPKKQYQNNDVEPLMRSGDQERMSWPELMSQQGTPGFNELYTSFWDYFYTNGVFPPKTWVSSSPVSLQRPPAGKRQPSFSNSTSTSSSAAGPSWVVHQPSVADQMYLQQQWQQNQMNQRQQQMGGLDQMNSPPSETPQHAPSLSSSLASQPHSGLSPRPMASLRTSVSSASVSTSNNLPFPAERQHPHQFQSIPNVQNTPNLEASTNKALFRSLSLPSPRPLTPSVHPPPVAKLGMPPISSTPRPVVYHDSVQLPDTANTPLQQDFDHTFTHPKRQDFPHTATLPSMLSQPGQDFRGNTLPSMQSLSDQERRPHAQTNNMQLATQYNPGTAGQDLTGADQTALTQNRENYSHVQQRQERSYVGSAHEQKSGGQDNSVTSSHQLNKSPGNNSLSKTASTGRPPPPYCPPNHSQLSSIPQNVSEPVHFGEPLPTYRESVAHTLCSSTGLYRSLSLQEPVKCRETLVQSGSIPEPVSSGDISAHPQQPSRPNTSLGLQSGLSRSSSRASTCSGVPEYQQHADSSLFRHADPDSVRQLCSPSQASISGSSKFLFEDKFTSLPNTNGGRCLSRLSEPCGDGPSSRPASCFSEPGVSEHVHRKKVKTNLIAADLLTGRSCGEINKLLQSAHSQNSIPVSYSSFCTSLSKNENSPSCNEEQGNQSFVKQEPREENFVSQLPQALQQIKIDPLDKKSLHSQAVLPAQMQQTSQQVSGTIFSQGVDCGQKTENITVVHTDAVSRVSECLPLKGEQMFHHEQQPYATPTSTVVTVGGTGVSVHPDGPMFGEKVKVHKSEGFVVPSNVEGPLEPPYKVIDSSVVVSKEINDNREVFEDPAMGGVAIALCHGAVIFEVAKRELHATTALKEPNRYHPKRISLVFYQHKNLNLARHGFEEYEKKTEERKSLAEQAKLIEELEANGFSKGELSQLSSFPSLTKGSFGKVFNFSEAKETVFPLRFPRYLDNSQLEQITPVMFACMYIAFPKYMKEAFPKVSCLPRLTNGYFSSKMSSTLADLRIQENLKNSESKTKPLKFQVDDLEKSGGSYRDLHSAWDPNAVEGFSPTTNTIVTRWVHQDTSVTGPYNQWIELLNLSDENSEEAEAMKDAVLREATEADLKEKMLESVLEMDDHLSSGKVDFQIGDITPSLPQAADFSSDEDIKFLEFVAQRENLQPSYGKLGSSNTSSGHVHGFPEGNMEFSASVTRRGDTQSSKDGQGQSNLSSLGQVHSSQVSSPWPTSLPGHTVVSVCPTTSNVAVDLNGLEKFHCNNSQPLRSDVLSEMTKDCSFTTKMTHENSLALRYSVNERTQGVQYPSNAQLSHADINDGVMHKSETEPGLDHASISRAGRNEGFPSPSGNGTNQVVMSRRQSMYEFLVSGFKEQRLPKPHTVNLSLIPDPVDLDQSMCVGPSGSAAKKAESTVRVGQVADLTDGNGKVLTSSEPGLDPNELSLKAECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGN6</accession>
    <name>A0ABM0JGN6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101849993</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093279.1">
        <property type="nucleotide sequence ID" value="XM_005093222.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849993"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093279.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="74783" checksum="FFA40DC25386A3EE" modified="2025-10-08" version="1">MTKSSFSPHQNLDAPRHGYEPSDEQEKMVMMQDKVSGLNLPTEKEGEMRSNALYNGASGEEVFITCPLNSSLEGGEEEMEAQHEARHKWGRKTEYVLSMVGFCVGLGNVWRFPYVCIRNGGGAFLIPFFICLTLCGLPLYLLEVSMGQFVSLSPYHVWSICPLFKGIGISMNVLCFLCSWYYSMILAWSLIFLVNCFRDPLPWTVCGQWWNSPKCITRHNVSSASADNNSNNSSYSFGLNSTASTLFIENGTFFNSSVNSTTDTTEKFVGASEEFWIRNVLQLSDGLHDVGSLPWQSGVALFVSSVIVFLCIVKGIHSSGKVVYVTATLPYLLLVVLLIKGATLPGAMDGVIFYLKPDFSKLGNLQTWVEASVQVFYSLGPVWGGLITMASYNKFNNNCLRDAVILSFVCEGTSVFAGFAIFTILGHMAHNLKVPVANFSDTGPGLAFVVYPEAISYLPVPQLWGVLFFVMLFTLGLDTQFVMCETILTTIGDLWPQFVGKSKVIFKVVFLFILFLISLPYATEGGMYLFQLVDWYFASFAMVLDGLLELVVVNWIYGSSRFLDDIKMMIGYRPPYLFVVFWRFITPAILLTVFVSTLMSYGPPVYHGYHYDSVGIGLGKFIACVPLIPIPAYAAYLFIKTPGTFIQRLKTTLSPSSQWQPADKRLRSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHK6</accession>
    <name>A0ABM0JHK6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101852677</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101852677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093821.1">
        <property type="nucleotide sequence ID" value="XM_005093764.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852677"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005093821.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14520" checksum="2A920302C2B6DF4B" modified="2025-10-08" version="1">MNVRVAVVKIMKASSLLSLGLIVMTTGVMCQRMNRNQLQDIMSGNIGTDNTMEDVLTPSTPRPEDVNCYVEIPTTETFGGRCIRLGRNGRYFYGCRAGLHLRISTACEVLARQPRWNTRRQRRRKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIW7</accession>
    <name>A0ABM0JIW7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase A2 group XV isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094703.1">
        <property type="nucleotide sequence ID" value="XM_005094646.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852165"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046017844" evidence="1">
        <location>
            <begin position="18"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094703.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45361" checksum="2C37C0E14FF4F8C6" modified="2025-10-08" version="1">MKATFIFLSIFIVCCVAGPRYPVILVPGDGGSQLEAKLNKTTAPHYLCQKHTSSYESIWLNLEELLPEVIDCFVDNMRLRYDKDKHSTYNAPGVDLKTHDFGGTSAVEWLDPNPVTHISSSIQYFFPIVKDLVSLGYVRGKSVRGAPFDFRKAPNELGEFYENYKKLIEETYRINNNSKVALVAHSMGNPVTLYFLNKQPQEWKDQYIQSFITIAGVWGGAVKTLRLMSSGDDLGVVIVNPLKVRPEQRAMPSTAFLMPTDQFWQPSEVLVQTEKRNYTVMDYKDFFNDMNYTDGYNLRLDTEKLIHEVTPPGVPVHCLHGLGVHTPAALVFPPGGFPDTYPKTVVGDGDGTVNKRSLLGCLRWSGKQKYPVKHKVFKGAEHMSILSLPEISKYIVSVITGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLL7</accession>
    <name>A0ABM0JLL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">3-ketoacyl-CoA thiolase B, peroxisomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101847816</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 acetyl-CoA = acetoacetyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21036"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:21038"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:39131"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74298"/>
            <dbReference type="ChEBI" id="CHEBI:74304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:39132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:40343"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:77081"/>
            <dbReference type="ChEBI" id="CHEBI:77084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:40344"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:21566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:31205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:18161"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="EC" id="2.3.1.155"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:18163"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096572.1">
        <property type="nucleotide sequence ID" value="XM_005096515.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847816"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="17">
        <location>
            <begin position="39"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="18">
        <location>
            <begin position="300"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005096572.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="45151" checksum="32E1594F014218B0" modified="2025-10-08" version="1">MADRLNTVFGHLRNQTVKSELEVRNTAALPNWLNKPDDIVIVAARRTPIAKAKRGSFKDTLNDDLLAAVFKAVISDSKINPEDIGDICVGCVLDKQAATVARLAQFYSGIPEDVPVYSTNRQCSSGLQAVMNVAGNIRNGAYSIGLAGGVESMTRQYGSSAAGFEVNPRVGDLQVTQDVLLPMGITSENVAAKYGVTRKEQDEFALLSQQKAMQAAKQGLFDAEIIPVTTTVTDKNGDERTVTVSKDEGIRPTTIEGLTKLKPAFKENGTTTAGNSSQVSDGAAAVLVMTRQEAARRSLPILGVIRSYAVKGCPPDVMGIGPAVAIPLALEKAGLTVNDIDIYEINEAFASQAVYCVKKLGIPIERVNPKGGAIALGHPLGCTGARQFSTLLHELKRRGKRSCGVISMCMGTGMGAAAVLEYPGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLQ6</accession>
    <name>A0ABM0JLQ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial uncoupling protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101862642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096635.1">
        <property type="nucleotide sequence ID" value="XM_005096578.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862642"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="112"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005096635.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34065" checksum="E3E9C39F81664CC5" modified="2025-10-08" version="1">MPLNHESFAFKYTLSATAAVVAESVTYPLDLTKTRLQIQGEVSKHAEGSSHSRPHRGMLATAAGIAKEEGVRKLWQGVTPALYRHVVYSGCRMSFYEILRERVFKKNPDGTFPLWKASLSGLLAGAAGQFISSPTDLVKVRMQMEGKRRLEGKPVRVKNTGHAFRQIVMEGGVRGLWSGWVPNVQRAALVNLGDLATYDTAKHLILSKTTLTDNYITHTLASACSGLVAALMGTPADVVKTRIMNQPTKDGKGLLYSGSIDCLVKTVRQEGFFALYKGLLPIWARMAPWSLVFWLSYEEVRKLTGTSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLY1</accession>
    <name>A0ABM0JLY1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC101854565</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101854565</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005096770.1">
        <property type="nucleotide sequence ID" value="XM_005096713.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854565"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="61"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005096770.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42604" checksum="DC4A34D265FF578C" modified="2025-10-08" version="1">MSVHNISSLAVTSVDNISCCLPGVVGGQRSGLISDAVSAIVTDLVLRVVVQFMLGVFCIVANIVNMIVFIKIGLEDGITVAFFALAISDLLFVGFYLMVNVLAFLHNVLKLRQYLHFGSLAFLLVWYSYAFFDASMLITVFLAVQKCACVAIPLLFKNVFTRSRCVVVVVVIYVGTFAWYMPLLSQQGMLERFDSRTNTTTLLYKKPPHAMFMLNLFKSVSRTVLPGICLSLIIISVIVLTIKLKQASKFRQASASHGNKDNNKNSDSSSTKQNPSSSKELRVIKAVTLVSTIFVVCYIPDIVVSCCQIFFPEFSDRGRYRNMRKLVDEIHSVMTTVNSSVNIFVYFTFNTRYREKLVSLRALFRRSRVEQKIDVYNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP03</accession>
    <name>A0ABM0JP03_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101858627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005098152.2">
        <property type="nucleotide sequence ID" value="XM_005098095.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858627"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005098152.2"/>
        </source>
    </evidence>
    <sequence length="448" mass="51187" checksum="6FB4292A5D52D8D6" modified="2025-10-08" version="1">MPRHMIPKLGSWLLRNKRHNLVILTVLCALCLLLWRRAEPSTNSTDLTFHKGSLEIREAAATTLITSNARLQAAANDSHNLRRQHVISHCSRKHGDQWSSRKQRVPKFSTSPIISTKHGLMYCPVGKVASSYFTRYVITLDQPGPMTSPYDIPIQKAGRDRCQNLASLGNSDKAVTFLQKAVKVVFGRNPFSRVFSAYIDKVYSPNPFYWRYWGERAIHLSGQQVKDKCASEVTFKQFVAVVVKELVTKDVHLKPVYEECKMCDVIYDVVGKLETTTDDIDFLSASLNVSSAFQHDGKYSYTASIDTVLDAVESPFSWKKDIQACMSLDEMGQRIWRKLQIRGIIDSRISYPFKAGEVDAMPSTKFVSACRSAVEASKDRAQLKKQKVQAFLEAYATLTLEELRDIVRVYQNEFDVFEYDTEPPRLFRDRGEVGKTDFLNWRVNWQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP61</accession>
    <name>A0ABM0JP61_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101845324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098268.1">
        <property type="nucleotide sequence ID" value="XM_005098211.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845324"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="530"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="186"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005098268.1"/>
        </source>
    </evidence>
    <sequence length="1200" mass="139091" checksum="EA064529D370407B" modified="2025-10-08" version="1">MYIKQVIIQGFRSYRDQTVVEPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHMRPDQRQALLHEGTGPRVISAFVEIIFDNSDNRIPIEKDEVVLRRVIGSKKDQYFLDKKMVTKSDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTKVYDERKEESNAILTETDGKLEKINDLLKYIEERLNTLEGEKEELKEYQKWDKMRRSLEYTIHDHELKDTRKKLDELQSKRDNSGANSTVLRDDLTAANDRVKTINKELKELKARMQAALEEKDSISTEYQELTKKNSKLELSIRDIVEDQRGNQNTKAKAESELAKVNEKIVKTQTQYDTVCQEYQNKLDNEEMCSTRLAEADQKRKELYAKQGRGSHFQSREDRDNWIKKELKSLNKAIKDKEEQISRLRDAQQQGQGQTANLQKEIADLEQDLENRKEGIEDNNRRFSEMKADKDSQQNKRNTLWRQENTLQQQLSTTTEELNKRLQGLRSLTGKGMLNGIDSIQKVLQSFREQNKYPEVINGYHGLLIEAFQCDKVYYTSVEVTAGSRLFHHIVDTDRTGTILLKEMNRMHLPGEVTFMPLNRLENRDTHYPNTSDAAAMIHKLEYEKKYEAAMKHVFGKTLIARSMEVATQFARTQNLDCITLEGDQVSRRGALTGGYYDTRRSRLDLQKSKVELTTLKQTQEVEYQSHRVELEKVEQYITNLLSEMQRLETKNSKNKDAYEKVQTDLRIKKEELSTLQNTQPSRGKSAASLESSLQAMKGQADALKEELGTELQSQLSVEDQRQVDFLNDQINKLTQENRQAWQERIKLETEKNKLENVLNNNLTKKRERLQQELREVSLEEQDKRLSGFKSDKEEVEKRMAELDASTTEVDSSVERLNKEQKEMQMNLETWRGKERDIQDKIGEDAKELDKISQKQSLLIKKKEDCMKKIRDLGSLPSDAFEKYQNMSLKQLFKKLESCNQQLKKYSHVNKKALDQFVNFSDQKEKLMKRKEELDSAQQSIIDLMKALDHRKYEAIQLTFKQVSRYFSEIFKKLVPQGHGVLVMKKGEIEGDGAEEEIPLVEQFTGVGIKVSFTGNKAEMRDMQQLSGGQKSLVALTLIFAIQKCDPAPFYLFDEIDQALDSSHRKAVADMIHELAQDAQFITTTFRPELLQHADKFYGVKFRNKVSHVECVTKEEAEDFVEDDATHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPR6</accession>
    <name>A0ABM0JPR6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein FAM162A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0389 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098657.1">
        <property type="nucleotide sequence ID" value="XM_005098600.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857116"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009432">
        <property type="entry name" value="DUF1075"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13674">
        <property type="entry name" value="GROWTH AND TRANSFORMATION-DEPENDENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13674:SF5">
        <property type="entry name" value="UPF0389 PROTEIN CG9231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06388">
        <property type="entry name" value="DUF1075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005098657.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17330" checksum="6D710A3A43C935E0" modified="2025-10-08" version="1">MFRTKSIHFQVINLLRRQISPEVPKPAQSRCKSIMTWDSLMAKKASRSRSTPQLLSKRHNIVDGGEGTYKPSPFEQKILVWTKTYPAVADIPERISRGQMKKSLDKFRVRCSIWMVGFTFVFAALMALMGRKARNEGQSVTSIALAKREKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRF9</accession>
    <name>A0ABM0JRF9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="1">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.1.4.12" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005099803.1">
        <property type="nucleotide sequence ID" value="XM_005099746.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847963"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099803.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="58280" checksum="1A90C901E0701494" modified="2025-10-08" version="1">MVKCAKSAPKVLVWLLHGTRWILYPSYFTFNALISLFVVTFQEEDKLLRIFLRKLILGPVYAGLFTLFLPFLIFFLPLRCFLVVLRNKTPYVLSVRHTALTDRETQYQNELIDSNDYKFGAGTANLCIMSEFLSRMNHLTDVDERSQKMGERIVVSQLFNDEWNKKVLKRKVVSQNSPGILSPADSGVVNKVNNNVHRILKKWTVEGDITTKFNRLDFIMVQEAWSSYHNKMLIDELHKVFPYVVHDVSVHGFGVNRFCLSSGLLIASRHPIIEIDFKPFKNFILHGKLLSKGLLGVKVLLGSDTSERRKVGYLFNTHFQSYQGTECVIAQQMDESIVSARQFMEQTRHDNEQVMFSIMSGDFNCDNLSPCDQGTANHELFNVYEDIARIRPGMDKPWTIGTEMRQRYMLEPAVSTPEGLKAALDDPVLRQRYVVDGDIELQSKEVLAAGLPKVDAQGNLICRQEGGRRRIDYITLHKDYPVNVEGYHFVTQLASLTDHIPVAIEFTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRX1</accession>
    <name>A0ABM0JRX1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Charged multivesicular body protein 2b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101845333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100138.1">
        <property type="nucleotide sequence ID" value="XM_005100081.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845333"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100138.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23893" checksum="AE0FABFCB3F61F2C" modified="2025-10-08" version="1">MAGFFSKKPTVQEQIRANDRVLRKQTRDLGRDRNALEREEKKLELEIKKAAQQGNKQAATILAKQLVNLRKQKTKSYAMGTKINAIGNQQKMMHSNMKMASAMGTTTKTMQQMNKVMDPQKTAAMMRDFQKESTKMDMTEEMIDDTLDDILGESGDEEEQDAIVTQVLDEIGIEISGKLADAPSAHGGKLGESSKRVSADDEIERQLAALKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSS7</accession>
    <name>A0ABM0JSS7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101848758</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005100666.1">
        <property type="nucleotide sequence ID" value="XM_005100609.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848758"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005100666.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31922" checksum="EFF389747221938F" modified="2025-10-08" version="1">MKLDGLRKMQDDLVKVIERDDTSTVTSDSDETIARGPKTLRETLDDVIHSQKFMVFIIVLVVLDCLMVIAELLFDLEIVKLGEEHHYIPKIFHYGSLGILSLFLIEIGLRIFVLRLDFFKHKLELFDAVVVIVSFILDIVFRDNEDAATGVGLLIILRLWRVTRIVNGIVLSVQKQAEKKIEREKHLREECEQELAKFREYCMAQEAEIEVLQGLLHKHNIEFTTNKITRPESRVQVDVVAEVNSMTAVAETDIPLSPSQPGEQEISLSSGDNVTDAVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU41</accession>
    <name>A0ABM0JU41_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvyl transferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101536.2">
        <property type="nucleotide sequence ID" value="XM_005101479.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854957"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="1">
        <location>
            <begin position="172"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101536.2"/>
        </source>
    </evidence>
    <sequence length="450" mass="52259" checksum="E2DF6F723436F5C7" modified="2025-10-08" version="1">MLVQPQSMEKVRRSTNDLYFVAQGGDMVRVETNDQNGAFQTDEVPFCTHCPQAYRRPPDSELEPDLTGYLQPYREEIQAFLQEPLVNNPERAVFLSQLLKTPGEIIRESQRLHFNIIGDVLKKYKAAMLFDIADFENKGDPCITVGEILFLARINLPVVYYCSSLSCTDENMRKARKLAANYSPDELVVLFHGGGNLVGYRFNDFFRFKTMDLFAGYHFLLFPQSIFYNNAQDEHVKLCEREYCCNENLTLVLRDLQTYSFAKEHFKGKTKLLLAPDIAFQIGNVNRFQSPVFDVMWIKRIDYEAPNYGSIPEHPSDVRFHVSDWWSWKTNDAPTSLEKAFYVSVEGFNFLSRGRVLVTDRLHGHILSTLMNMPHVLVDNRYKKLSSYHNSWTKGLENTKLTNQPEKAMAMILDLLDVHQQDLPPRVPFMDLAENFQQRNFEEEEFAKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVJ3</accession>
    <name>A0ABM0JVJ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102544.3">
        <property type="nucleotide sequence ID" value="XM_005102487.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846749"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102544.3"/>
        </source>
    </evidence>
    <sequence length="456" mass="49604" checksum="8F0BB5BFDCA3BFEE" modified="2025-10-08" version="1">MGCSASSTAALSQGDVIEKKDSSQVIDNSAGGDKSMPKSNKVSAQQMVKKESQTSSKGIRISTKAPREQPPPFKKTPKEAGGSMAKNAHTDKGGGADERIGKQLTSSQQGSLPGYLTDEKNILKYSKTSSSQIVTKRSSVIARKLESDRIEDEASVDIPMSTKTPKEHPGPASASTKTSSTIATSMSVSSTVAPVNDIILEDNLESSSVTNLTQRNGSNICVAVKNVETTEARSCSTSDLSPNIEAKLSIAQVSTEEPVSRSDSALSKRRADKSKHRGSKSTNPSTPAGSLTAVSKSNENVDGRPRSSNSHRHHHHHHHHHHPHHHAKYGTHSKITSPKKTFKFTSKDEKTQFFVKTVKSNDENDEDLGDTKDILIQTDVVTVNDHNEKSKKKLLIKMKKLGSKESGAKLRMLKPRQGSEKGKNKGKEKKKHGENEKEKELTTEELEEEGRTLCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVY0</accession>
    <name>A0ABM0JVY0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-alpha-acetyltransferase 20</fullName>
            <ecNumber evidence="5">2.3.1.254</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionine N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">N-acetyltransferase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">N-terminal acetyltransferase B complex catalytic subunit NAA20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">N-terminal acetyltransferase B complex catalytic subunit NAT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">NatB catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">LOC101858349</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-terminal L-methionyl-L-asparaginyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50484"/>
            <dbReference type="Rhea" id="RHEA-COMP:12694"/>
            <dbReference type="Rhea" id="RHEA-COMP:12695"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133356"/>
            <dbReference type="ChEBI" id="CHEBI:133358"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-aspartyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50480"/>
            <dbReference type="Rhea" id="RHEA-COMP:12692"/>
            <dbReference type="Rhea" id="RHEA-COMP:12693"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133045"/>
            <dbReference type="ChEBI" id="CHEBI:133063"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-terminal L-methionyl-L-glutaminyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50492"/>
            <dbReference type="Rhea" id="RHEA-COMP:12698"/>
            <dbReference type="Rhea" id="RHEA-COMP:12699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133361"/>
            <dbReference type="ChEBI" id="CHEBI:133362"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-terminal L-methionyl-L-glutamyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50488"/>
            <dbReference type="Rhea" id="RHEA-COMP:12696"/>
            <dbReference type="Rhea" id="RHEA-COMP:12697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133359"/>
            <dbReference type="ChEBI" id="CHEBI:133360"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.254" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005102774.1">
        <property type="nucleotide sequence ID" value="XM_005102717.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005102775.1">
        <property type="nucleotide sequence ID" value="XM_005102718.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858349"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005102774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_005102775.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20086" checksum="C80771B17261566A" modified="2025-10-08" version="1">MTTIRPFRCDDLFRFNNVNLDPLTETYGLPFYMQYLAHWPEYFQVLESPTGQIMGYIMGKAEGLGEQWHGHVTALSVAPEFRRLGLAGKLMNGLEEISERKRCYFVDLFVRVSNKVAVAMYEKLGYSVYRRVLEYYSGDVDEDAFDMRKALSRDTEKKSVIPLPHPVRPDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWI5</accession>
    <name>A0ABM0JWI5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chondroitin proteoglycan 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101854510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103174.2">
        <property type="nucleotide sequence ID" value="XM_005103117.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854510"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046451895" evidence="6">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="165"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005103174.2"/>
        </source>
    </evidence>
    <sequence length="229" mass="24870" checksum="A7D2CDEF5431BC86" modified="2025-10-08" version="1">MVTKILLVSLALFALGTCQLTINLCTQYGWPNGNYPDPYDCLKYINCNGAIATVMSCAPGTVFNPNTRNCDNYGNVPICQSTQQSPIVVTNICNQFGWGNGNFYHPYNCAQYIQCANGLTTVNACGAGQYYDQSLGRCALAGTGYCLQYVFTPPPTPVVYPDGFDSYCSVNNLSNGIHPDPYSCFSYVECTFGRTTHMPCPSGLSFDRSLLVCDGNRYQNCGGNVLVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JX29</accession>
    <name>A0ABM0JX29_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myotubularin-related protein DDB_G0290005</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103594.1">
        <property type="nucleotide sequence ID" value="XM_005103537.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852946"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103594.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34359" checksum="CD784484D7AF9901" modified="2025-10-08" version="1">MSSEQSNMKHHHHHHHHHHHHHNKNSADETCSSKFTGSNGNQSPIKQLPKGRGKESRTQGSPRTAVASSTPTKKRGSSSRAKRSVGPPRCAVNGPLYSCLNSPAVACKNYGSSTDDTLKTVRPPNPYTELLKNLGAEDITKMPDMYGLASPAKEVSPPPSLGQDGAKTTTTSITVSTTTSITTTTSPITSARDDRGSGEPRSEAGGDGEDEEDEEDEKGMPNAVRMPEPSKICRTSIQEQVKERHTRAMEDIARSQEPGEILAHLLTSGYFNVCYWDHARTTVDNLNMKNGRKKGVERLYSLLCKRIPNMIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXL8</accession>
    <name>A0ABM0JXL8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101852340</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101852340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103926.2">
        <property type="nucleotide sequence ID" value="XM_005103869.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852340"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005103926.2"/>
        </source>
    </evidence>
    <sequence length="128" mass="13977" checksum="1AC07D552F6142BC" modified="2025-10-08" version="1">MDASAEPATKANLLSWVKIAVAVAVIRCKPPGDSALKHAERICSKFWTNQLSLQTNFQQTKAELSHLQKQLTEEKNVPRGTAEKCHNLSPMQVLSGRHHDLTPPPSVEYVAGQVGLSRHIASRGGSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXX6</accession>
    <name>A0ABM0JXX6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GRIP1-associated protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104151.1">
        <property type="nucleotide sequence ID" value="XM_005104094.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864239"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026204">
        <property type="entry name" value="GRIPAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18978">
        <property type="entry name" value="GRIP-1 ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18978:SF1">
        <property type="entry name" value="GRIP1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="824"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="836"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104151.1"/>
        </source>
    </evidence>
    <sequence length="915" mass="103253" checksum="2789080A0D288F88" modified="2025-10-08" version="1">MASALSEDEFHRMQLQLIELRTTNYELEGKNKKLERDLSEIQEKTDYFDRELAKAKQAINKSKKAKDVELLLQESDSLQRKLVSQEEEFRLQNQTLMEELGLLVSSNEEMKKELEAAKSQAASTPSSADNDINSSNSDELRRLQAENAALQKNLTVLQEKYEEVSSSKNKVSQRATSEAADQLGDESNAAAEEKTDDVVDGSNDRVTQSTDQTDSVKLQLELDTEREEKRILKAQLEQIQRDTKTQIAALQEEVDKGTDRLKKKQESFMQVQSEKETLFKESNLKLEESQAARDRDQKYYKDQIVKLQQDAERNKKEVEQSQMSSDKETDGLKSKVKELQKQVDASNLVTNHQLQEQGAKYIAEIDGHRANVAKLTKERDDLTTQLQESRRAAQEAVTQLHEAQTERDSQISAMQEVSKVAEKRKSLLDELAIKYQKEYDDHRQATTQMEADHAAEKEKLETSIEEQSKKIAELNRQLPVIEELNKKVSSLDESKGWLERRLKEVEDQLSSTTKAGEEEREEMTTRHKTELEELTSSHAQEVEGLKEERRVADEEWVKKEEVLKGEVEGLKNKENNLRQAIKDNVDEKKIHEKKGMTMLKDLKRQLHAERKRAEKLQLRLQEVLSDTSSKGMEDLFRSSESGDFAFGDTSSVSSWGAGASGLGKDSVASGPQSPMSGNNSMISEGSVGEEYNDLLKRVAVLQQDKWGLEEKVNHLEMSNACMAEDILNKTSIIEHYVMDSRSGPKQQSQSSQEEKLSLKKVMDMVNKNSEHAQHTQDMNKKLQSMLEETLTKNMHLQQDLELMSQEVVRLSKLSAVMASARENVATVNQPTPPSTLPLETKTTTTNNTSSSATPSLSATPATTGSSEASDFSNNCPDSGVISSELSSPDELEHDLSDQIEDLRENSSETVDPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYE1</accession>
    <name>A0ABM0JYE1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Potassium voltage-gated channel subfamily H member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101860035</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005104472.2">
        <property type="nucleotide sequence ID" value="XM_005104415.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860035"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003949">
        <property type="entry name" value="K_chnl_volt-dep_EAG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01464">
        <property type="entry name" value="EAGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="16">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="461"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="628"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="758"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="915"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="628"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="767"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="957"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1008"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005104472.2"/>
        </source>
    </evidence>
    <sequence length="1081" mass="119797" checksum="E4E09F633564E4EC" modified="2025-10-08" version="1">KQLRIAVLLCPPGTPLWLLLHVAPIKNEKDQVVLFLCTFKDITALKQPIDDEAGKGLSKFARLARSVTRNRSTLLQFSSHQPSTKFDNSRPSHLANMMNLSTDVLPQYRLEAPKTPPHIILHYCLFKTIWDWIILILTFYTAIMVPYNAAFKVKTMDQLPLLVIDSMVDVVFFVDIVLNFHTTFVGPSGEVISDPRVIRMNYLKSWFVIDLLSCLPYDVFNAFQYVDDGISTLFSALKVVRLLRLGRVVRKLDHYLEYGAAMLVLLILVFILFAHWFACIWYSIGWAELISGVEYGWLPELANVTKEPFVAANTSASDDRLGGPSKEMRYLTALYFTLSCMTGVGFGNVAANTQTEKLFSVFMMIIGSLLYATIFSNVTTIFQQFYSSFARYHDMLNSVREFMKLHDVPKSLSERVMDYIVSTWAITKGIDAAKVLNYCPKDMKADLCVHLNRKVFLEHPAFRLASDGCLRALAMHFNMTHSAPGDLIFHQGESLDALCFVVSGSLEVIQDEEVVAILSKGDVFGDNFWKEQSIGQSTANVRALTYCDLHAIKRDRLLEVLDFYHAFANSFARNLTLTYNLRHRLIFRKVADVKKEKELAEKRKNDPPLDLANDHPVRKLISRFRKISDTKHDVKQQNSHDAERGSSSSMAVQEEESTTPSETPKAGGARIITVSESPNVETGKVAPRLGGGASRWGRFLGGATSGSSSTDSANDGKGGDKAIPLNDLSPKIETRSGEAPKITTKPMAKWGRFLAKAQEPIEESPEEDPKSTNLKKTDSTDSGILRSNNKLDQIGEEMLGLDGHHLLHHHHHHHPHSLQTTLNINTMNNLTRETLSNSSNSTNQSIGAAASTSMPATVSGGLSAAEQHMLTSLYDIRLEIKEEIDSLRQKMNRIDEHISEVLRFFSPVSTPCSSVSTYPSSKFNSPQNVTTSNSADASPKNSVSSSPRHEEAGGGESSNLTTGEVTPMNISTEASGGEEQPVLRSRPTQNPPEQIAAPQESTSRKKSGNGNSGKKSNRGNGESSSSSRRSSKSSNSSNESHKQSSGTPEPVPGRVHGSTQVDVPEEEEELSFPNDHDPDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZW9</accession>
    <name>A0ABM0JZW9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein adipocyte-associated 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101847894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0359 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105461.1">
        <property type="nucleotide sequence ID" value="XM_005105404.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847894"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018781">
        <property type="entry name" value="TPRA1/CAND2/CAND8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10160">
        <property type="entry name" value="Tmemb_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005105461.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="43798" checksum="289338B5C2E9A22A" modified="2025-10-08" version="1">MNETTDDGHVPGNSSEISVPTSASMIPGNSTEYPPIPFHDLTIPPCQWILYADINDSGVRVWDLIILVPNSLFLLFLCLRMRPAIAKLKASNSPIFTAFYALVFIVSLVGVVRCIVSMTVNASTAAGDVTDKVLWLLLKFFLLATELSVIIFGLGFGHLDSRTSIRRVLIVTFSFALVYSAIQCILELEYDHPSFTGKSSGKGNSTGDISYDLFAHGGMIFLFSTSIFFFLIYSIITVLPFTRIRERFHLPTKILFYVYCIVLAALNLSQAVASILLYMMNAPSLCVIDVTSYAYFSLYNPLVYGVFLWKFFETAQTGLQFSYKSQDDEVDEDQLSLPYSTAVHKNEDHAPIFSYDSTHFDVQYSRSNSFGSNTTAIPSLSVNSDFNSSANMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K056</accession>
    <name>A0ABM0K056_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847896</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105639.1">
        <property type="nucleotide sequence ID" value="XM_005105582.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847896"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046962341" evidence="2">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105639.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11709" checksum="A0BF91693C109811" modified="2025-10-08" version="1">MNAKLICALLAGAVMLVSVCTAEDNRLKRHYSHHGSYRRPPYNRYPYPGRNPGTNNPGTNNPAVGLPIGQPTTVNQPAQGPVTINLTAQQAQLLRSILALLGNAGAAPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0N9</accession>
    <name>A0ABM0K0N9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B14.5a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101848459</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA7 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105986.1">
        <property type="nucleotide sequence ID" value="XM_005105929.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848459"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07347">
        <property type="entry name" value="CI-B14_5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005105986.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12786" checksum="BFCC1F1098837DCF" modified="2025-10-08" version="1">MAAKPNFRDVTPLLSRLRNWLLSHDELKTTHRYEGFIGKRTQPLPNLPPGVSHKLSNNYYLTRDGRREVAPPAAVFDASKNLLEAGESSGPKKPALPGFSYNWQTGRLEDGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K200</accession>
    <name>A0ABM0K200_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ homolog subfamily B member 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101852720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005106865.2">
        <property type="nucleotide sequence ID" value="XM_005106808.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852720"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="127"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005106865.2"/>
        </source>
    </evidence>
    <sequence length="384" mass="44159" checksum="27D3209C3BEEA458" modified="2025-10-08" version="1">MKFALATTVVGSCTAVIKMDGNKDESEKCISIALRALSAGDKEKANRFLLKAQRLYPSKKATDLLDSLDKLSSNGEAQREKESESSQPRHRKHSHSKGGDEADKENKHADYTADQLASVKRINECKDVYEVLELSKEFSDSELKKAYRKLALQMHPDKNKAPGATEAFKAIGKAYSILSDKEKRRQYDLYGPEMQPSRPSHDHGDFSHGFDGDISPEELFNMFFGGGFPSGNVHRRQHHHHARRTYYTYREPQQSESGLTLFFQLAPILLLVVLSMLSSFLVSDAVFNLQRTEKYRVERTTANLRVTYYVKDDFRAEFKSDLRRIERAVEEEYIGQLRNNCFRERNYKENMMWRARNYGDAKLYQRAVDMATPSCDNLQKVYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K243</accession>
    <name>A0ABM0K243_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101851292</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106948.1">
        <property type="nucleotide sequence ID" value="XM_005106891.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851292"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039499">
        <property type="entry name" value="LURA1/LRA25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14854">
        <property type="entry name" value="LURAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106948.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31508" checksum="406486248BD2BF0E" modified="2025-10-08" version="1">MHNTTEIPPVPRCFSHLVVSADGEEHPISHSSSPSSSPKSAHSYLNVPSSNILSRSTHDDTNVSVPKHLGCLVTPPGSKNDPSNCATTSFQEPDGTFSNDLRSSLSRLQLVSRDFDEDSGSLQMQGDGPKSYATSPDLHRKPEMLEELANESIPSLNLRTRHTETNDPKSPFVKLNSSLVKLQEEMKSLRYIDITLFYQLVSLHEAIQDFKLNMTDRFSETGSEYSLGTASYMGSMSSLNESDWTEDGMTHDDADVDTSTEDNRKSASSLLQQITDLAMRADKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2G8</accession>
    <name>A0ABM0K2G8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107183.1">
        <property type="nucleotide sequence ID" value="XM_005107126.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847139"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14366">
        <property type="entry name" value="CUE_CUED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040195">
        <property type="entry name" value="CUE_CUED1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040192">
        <property type="entry name" value="CUEDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467">
        <property type="entry name" value="CUE DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467:SF3">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
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        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
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        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
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        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
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        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107183.1"/>
        </source>
    </evidence>
    <sequence length="664" mass="73961" checksum="21E182CCF0B3627F" modified="2025-10-08" version="1">MTETDQLSRMRGVNQAEESPGRPPGRPMRQLEFHQAMSDFRHMFPETDEEVIEAVLRTNNGMVDATIDQLLTMNIDTEGNEEDEEDDDLPDHVLMSVERDVQLQQQQQMTQSTSRRLSREARATRKLLTSEGKGQSKDSEDCPPSYTEAVQSHLTSHHHRSSAGGGSNSRSRHRTPPSASAAASNGHLSRPALGTMQHLLDLGPDTAPSASLAAVGPPAAPQSAANSAKGHHSGHHHSSHHHHHHNTHHHHVSRSSNHHRRRAEFSESSPHKVRPGRNLLASASGSQHEALPEDMSFKPQRKGSVDSNNFSLDGSGEKSSHRWRSTYRQQSSGGKRPAFRNWNPPMLGTLPDDFLRISPSLSSSGPARYGGKHGPHLHRAMSAVGPERPQFYPLSSSPTSAIGQGSSTVPHSQSTRHRSSTHKPHRSLSFAGHTGQQGLPKRSQTLHPSGLAQHEFSSDILQERFKENERRRRMTSGDLDPDLAQYLEDERLAIMLQNSEFLQELRGDRMFMMTLERDQRSVETEKTKPDPPPAEPEPVSAPFSPDENIDNFIEGYGDDRQDTLEAFPFSQQLPPPVNEDVELRKKLKNMSRASRKQFAALARRFFLKRKKKTAQQILKESQAPSMANLLDEDDENDDVEETTNGYDGADASGVSESYDSSRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K366</accession>
    <name>A0ABM0K366_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transportin-1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005107700.1">
        <property type="nucleotide sequence ID" value="XM_005107643.3"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
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        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
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        <location>
            <begin position="352"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005107700.1"/>
        </source>
    </evidence>
    <sequence length="887" mass="100490" checksum="38315D8D5C2515AD" modified="2025-10-08" version="1">MAMWQPAEDGLRQILQLLKESQSPDTETQRAVQQKLGELNNYPDFNNYLIFVLTKLKTEDDPTRSLSGLILKNNVRAHFERFPAEVTSFIKQECLNSIGDPSPLIRATIGIIITNIISKGELHKWPEVLPHLCTCLDSEDYNVCEGAFGALQKICEDNAETLDSDIADRPLNVLIPKFLNFFRHQSPKIRSHAIACVNQFIISRTQALMVHIDTFIQNLFFLAKDEDTEVRKNVCRALVMLVEVRIDRLMPHIDQIIQYMMERTQDGDDTVALESCEFWLSLAEQKVCKEVLGPHIERLVPILVKGMRYSEIDIILLKGDVEEDEMIPDKESDIKPRFHKTRTHSTQKHEGDEEADPDEGYDDDDSLSDWNLRKCSAAALDVLANVFHEEVLPVLLPILKETLFHADWDVKESGILVLGAIAEGCMSGMIPHLPELIPYLINCLADKKALVRSITCWTLSRYAHWVVGQPHDNFLKPLMTELLKRVLDANKRVQEAACSAFATLEEEACTELVPYLGFILETLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNKPEYVNMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVCLVEQTLTQNFANMSQPDQYDPPDKDFMIVALDLLSGLAEGLEGHIEGLVANSNILKLLFQCMQDPMPEVRQSSFALLGDLTKACFQHVRPFISEFMPILGANLNPEFISVCNNATWAIGEISIKMGADMQPFIGMVLTQLIDIINRSNTPKTLLENTAITIGRLGLVCPQDVAPLLQQFIRQWCTSLRNIRDNEEKDSAFRGVCLMIGVNPSGVVQDFIFFCDAVASWMHPKPDLKEMFYKILHGFKTQVGEENWSKFSDQFPQPLRERLSANYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4R0</accession>
    <name>A0ABM0K4R0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">cAMP-dependent protein kinase type II regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101847613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108712.2">
        <property type="nucleotide sequence ID" value="XM_005108655.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847613"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12099">
        <property type="entry name" value="DD_RII_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0114">cAMP</keyword>
    <keyword evidence="3" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="169"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="291"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108712.2"/>
        </source>
    </evidence>
    <sequence length="413" mass="46363" checksum="4B25FB3EF7A044A3" modified="2025-10-08" version="1">MQTVCITKEISLFLIFLSPSQIFMIMNIQIPEGLGSILCDFTVAALEAAPSNLLEFAADYFRRASEAAKTTKNDGKAKDYQEMNGFGPAPNKSKVPMYIIVDDDEEAKEPDPETLKPKNSKNKYARRGSVSAERYDPEADDVTDDSKVVHSKTDSQRERLAEAVKGILLFKSLDSNQLSDVVDAMFEKRVTPNEAIIKQGDDGDNFYVVDRGRFGVLVGAGTDMKRVHQFDNSGSFGELALLYNMPRSATVVAETEGILWAMDRQSFRRIVLRAAFKKRKMFEQLLKEVPLLNSLDEYERMNLADALQTKEFAPGQNVITQGDEADGMYFVEDGTLSVIINKQGNPVEVARLQKGKYFGEVALIEDKPRTATVQAIEKAKVAFLERESFERLLGPCLDIMKRNSTEYKKQNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4R5</accession>
    <name>A0ABM0K4R5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thyroid peroxidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108720.1">
        <property type="nucleotide sequence ID" value="XM_005108663.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849496"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005108720.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43500" checksum="DC53E84993586666" modified="2025-10-08" version="1">MRNFPVNSLLDHLSRVPLDIPFGPQPDFGPSPGPFIDTGPCNPIYIPPLDRHFRYSCMNFARSQASPRKSDCNPRARKEPREQMNMLTAFIDASQVYGSTLKENRRIRLYRHGMLQVTPLDLLPNDKNSTCVKDGPGDYCFLAGEMRVNEHPSLSTLHTIFHRLHNQMALGLFELNPNWSDEKVSMSHVITFGHTLIPSKFTVGREKIRLFRMFNRPRFVLRDDGRSIGKFCSGLMEDHVQRYDRFIVNDLSDLLFQDRDNISMDLASLNIQRARDHGLPGYNEYREVCGMHRIKNFEQFYREDPERAVIFRRVYDHVDDIDLFPAGVSERSLPGAVVGSTFACIISQQFRNLKFGDRYWYENQNRPMAFTPGKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K517</accession>
    <name>A0ABM0K517_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PSME3-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101859272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108932.1">
        <property type="nucleotide sequence ID" value="XM_005108875.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859272"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005108932.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27719" checksum="E0D109E0558A6EAE" modified="2025-10-08" version="1">MSGQFKKFVSEEEVHEQRQKRQEEWEKVRQPDDPVECPEEETRSLFDQLQANKDVKDRELEEDSRLRSSVKGLDDEEVQFLNYVSNRQMQIEKDRNSEEQSVIKELKSKSVITVEDKKRASATASSSSTSSSSGSSSSKKSQLQLLSGAIKRKSTDSKSETDEKKAKPDEEEERPDAKLMANLPPSNGMMQVAGILPGIADYDDEDSSTENTSNSSDSEADHVIMPNKAVQRVLQEIAQKMKAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5W5</accession>
    <name>A0ABM0K5W5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ficolin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109459.1">
        <property type="nucleotide sequence ID" value="XM_005109402.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864097"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109459.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37153" checksum="62A781B2934B5BEA" modified="2025-10-08" version="1">MAKVLSDVVDENKRQCPHQLLAQKRQILARVEKALMQNNREFLQKTEGLLDNITAIVEQANKELQRQRDDVLEDVTGIIEKGNRECLQQKDDILENVTAIVQALEASFESKLKTKEIQKKPRTCVEVQSMDPRLVVTLDNGMTVVCDTKTDNGGWVVFQRRASANVDFFRGWLGYRDGFGDLHSNFWLGLEKVHQLTKMERHELRIDFSFQGTDYHAKYDNFSLSGESENYKIHISGFSGNMEDNMDYHNGHEFTTKDRDNDKSSSNCASTYHGAWWYNSCHRVNLNGDWGSTESSMGLNWKAVTTYSKSVTFSEMKIRPFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7C4</accession>
    <name>A0ABM0K7C4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101845048</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110483.1">
        <property type="nucleotide sequence ID" value="XM_005110426.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845048"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="31"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110483.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29997" checksum="A217758A3C8676EE" modified="2025-10-08" version="1">MTPDPHGMTYLMSLATLYTIETINTVVLSGLVSIFGVISNLVNLTIFWRHGFRESINVGLTALAVSDLGTVISGAILSVCFNPLIPYSEMRVNNRDVQYLVAAHPRFCFARITGLITVYITLERCLCVALPLHVKRILTPRRTFAVVVLIFTLIFLIETPIYMAHKLDWKFSYALNRSVISLVSRSNAAELENLSFGLSVCVQLSSFGLLLILTSTLVLLLKKRSEWRLQTTSTGASDKNNVSRRERGAIRLTLMVDVDGSFKLFQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8G8</accession>
    <name>A0ABM0K8G8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBL-interacting protein kinase 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111314.3">
        <property type="nucleotide sequence ID" value="XM_005111257.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855384"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111314.3"/>
        </source>
    </evidence>
    <sequence length="299" mass="33657" checksum="1E2733560B41A831" modified="2025-10-08" version="1">MLSLVYSNILTRNLNIFSTMESLTIPDVPLISGDFLSTMKLTLVKEICRKKKTPVQVLEVTLQEEPSVHKAIKKIGRFNAKGCDCWFNILREVSVMNSVSHPHVMKMDWAVRCEDYVAICMPLCPRGHLGRSCVRLSQEQIERCFVQIACALRYLHDKRIVHGDVKPENIFLDSADNAYLGDFGTSYLLQLGQDLVSKWKGSRGFVPPDAMHTGPCAVNPFLAEAYALGATLWAVFFKVKPVGEDLLATVESCSVMPDTYRAILMRLVQKKAELRHSIHALLAFIHVHTDRLRGLIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8V6</accession>
    <name>A0ABM0K8V6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101859528</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111601.2">
        <property type="nucleotide sequence ID" value="XM_005111544.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859528"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046725663" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005111601.2"/>
        </source>
    </evidence>
    <sequence length="145" mass="16753" checksum="00C2960E083E15C9" modified="2025-10-08" version="1">MTSPLTALALTLMVSLVMVEGLGSWKRRPWYPDDVQQMLPQYYWSTSHRRAYYPCAQTGLGCNDDKKCCSKHETCLTELKYNRRSNSCQDLRPERTGYKTLGMYSRTYVLRSIEDLSVAPSNHPQASMWQYPILAIPLQKHNVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8W0</accession>
    <name>A0ABM0K8W0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vasopressin V2 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101862621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111608.1">
        <property type="nucleotide sequence ID" value="XM_005111551.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862621"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF83">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 150-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="81"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005111608.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48107" checksum="8D3FE8A9FE60F08D" modified="2025-10-08" version="1">MATDSLISPSSNMGNPQVTTPTKALVSWSSILSGNDSFGNGTNFTLASDYEEELEKTVHDMEYNTDIRKAILYVQIVVGITGALMLFFYMLHSRRLSRVNALILNLCVADLMVVTFSCVTQLVWEHLDRRWLAGDVMCRLIKLLQIFAICASTNMLVVIAVDRHQAITAPLRKQFSVLVMAAVGWGAALLCSLPILYVFHVRYDEKKNVTLCENIFRNRPREHRQAFLTYAGLVNFLIPLIILCVCYIRIFLKIARKASDSRTTKRQSFKPGKIHLTSSTTSATLQSAKLKTLRMTVVIVTCFIVCGLPYFIAEMILSYGDFHMLSKSVYALLGGIAVANSAVNPYIFLLFSVNHHCLRSLKMCPAQTGPNNRQLMYNGSVRSREYSTAAYSRTPVTNVSTTDALELTTTTNTKANKEARFYQLKKSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K965</accession>
    <name>A0ABM0K965_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101845969</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111861.2">
        <property type="nucleotide sequence ID" value="XM_005111804.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845969"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045156376" evidence="2">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111861.2"/>
        </source>
    </evidence>
    <sequence length="129" mass="14438" checksum="6304ECD360E92BDD" modified="2025-10-08" version="1">MRSLVLVSLAALVLCAAVSAQDSDGSDTPPRIGRPKTDFSGQERPNSDDSAPSKKGKRLFLMIRSLERVLKNLGQADYAEESWKDCIKDTILGMKDYLEEEDDDIETQGSPPPPKPRGPRRRQQRRGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUX6</accession>
    <name>A0ABM0ZUX6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ganglioside GM2 activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934962.2">
        <property type="nucleotide sequence ID" value="XM_013079508.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854698"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E1_DerP2_DerF2"/>
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    </dbReference>
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        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046882791" evidence="2">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="3">
        <location>
            <begin position="72"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012934962.2"/>
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    <sequence length="221" mass="24256" checksum="562D0635205E273A" modified="2025-10-08" version="1">MQVYGILVVLATVCLTSGQPLSTSEESELSSARGEVVRMWHFVRAVMRNLPSVAGTVPTEPSFRARDSSFSFKNCGNPEEEIIVVSDVSMKPDPVSIPGNVTLSGNVEIKDRIDAPINVDLELYKQLFGLWVKIPCVDNLGSCVYEDICQTLKEIECPEQLKRLGFPCKCPITPGNFAVKDFVYTIKESLPIPVSGDVRIVANVYSNDVLVTCAEVELKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW89</accession>
    <name>A0ABM0ZW89_APLCA</name>
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        <submittedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 21</fullName>
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        <name evidence="5" type="primary">LOC101858698</name>
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        <name type="scientific">Aplysia californica</name>
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            <taxon>Euthyneura</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
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    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RAN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00174">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
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    </dbReference>
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            <begin position="180"/>
            <end position="211"/>
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            <begin position="181"/>
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        </location>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_012935835.1"/>
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    <sequence length="211" mass="22846" checksum="DE156188B6502580" modified="2025-10-08" version="1">MPTQGTSASGLAPSKPSFRVVMLGDQGVGKSSISHRFIKDDFLENNAPTVGAAYLTRVMKVGEQTVKLDIWDTAGQERFASLAPMYYRTAQAAVVVYDICSKATFGRALEWVKELHTQAPPNTIVILCGNKADKSEQRQVNDEEASKVAKDKGLLFTEVSAKTGVGVQDIFQVIANKLAGKSNNPVNSPPSEETIKLKKENHQKSSCPCTS</sequence>
</entry>
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    <accession>A0ABM0ZWT8</accession>
    <name>A0ABM0ZWT8_APLCA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011354</fullName>
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        <name evidence="3" type="primary">LOC106011354</name>
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        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
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            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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        <source>
            <dbReference type="RefSeq" id="XP_012936126.1"/>
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    <sequence length="128" mass="15377" checksum="D16BBBC0A00CC9AE" modified="2025-10-08" version="1">MYRISSCARQGIEPENIKGDYPYFDLDRPYYGEQELLHHYPNLYDFRRAAAFREPPPVFAPYNRPLVPPKDRPSYMKGKDYRVTSDWLSKWGDKRILLYRCQNVKEFPRKTPSEPRDTKTHSSTYKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Filaggrin</fullName>
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        <name evidence="3" type="primary">LOC101858850</name>
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        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
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            <taxon>Euthyneura</taxon>
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            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936192.1"/>
        </source>
    </evidence>
    <sequence length="1670" mass="188076" checksum="E198627F5347F150" modified="2025-10-08" version="1">MSFCVSHVSALDKNIRHLYSGLPSEVRFRQYTNSTKGAIDIHDRVAESQRRSPDRFNNKFREYVPEYGTHLPRAPAFRSVSPQEVKEINNRLTRPTVVSFIRHKSGVSRSAKSRGSPRGRLSDHGENQEEGEGETEEDGKGGGGGAYENDAGLKRQQQRPSGHRRVVPCSDWSDEEGGGGGGYYYVDEDHSGYGSERSEEKQGRFQSSIKHPGLSNSRYHSHEKGGRMREQTNKDRMSDRERKEEDRLPLVESRESERRDDAHRSSAYESSDNDFQDRDVIIQNGDTTCEEDLSQQDKTSEKDGPEDKDCDVKNNNTKKARRKTIGSASTVSRKSVNSRSGLGYSPPKRRLLILEEIMRSKVPARQRQNVKVAAARRSQWEKERVKLDRREKVDNRLSQSPYCEPMPRLYVMYPVQPYSMSASKQPRGRAAQRRSLHQQSTRGSVDHRGDGAVGSRSIDAIGSRPHTRTGAAASVHRREEISYNYRPEARGRVSDTHQLSRVKSAPLRTTTTTQQASIIPPESRFTSSSTATQAYSNRPTRNNSDPPKGQSGDRGVKSRSPEKGKTSDSGQATKKAENDFEKKDAKRSGDVHHPDRRTTVQGRQSRNSAYRTEFDTFYMMHNGTLFEQNPRKFSSPAEMERANARLMKPTTTKMIRDRMRWAPDNEDLADPVRVVQESVEEERSRSKKTDRRGRVTEGPHSDDSSDANCDDDDDDDDISDHEQKKKQQRHREAVTVKETKGAKIKKEKSPAPASSKPKLVRGAPRGLSELNKASKRDGDEGENVNEKTELATPKQKKARLTKQGGSEDESKMQEKSVANEKAEKTLSRSRSYSSDSSGRSRSPKREISRSRSRSRSRSQSRSRSVSRSRSRSRSGSRSRSRSRSRSRSRSRSRSRSRSASSRYSRSQSRSGSGSETEKETSRGSQTEQRDMETRNISEGVARGGLNTVESDSKTESISQKENRDVRNYDGDDEKLESEGNRIDSEATEADGEEERHMYSVGFRNSRGDEDRDTTGRGEDETQNVSKKYANLESRGDRFAATETEKQSPSPDCVTYSVKEDYRSGRIGEEGGEEGGEEVEEEEAETTVSGVEVESGESEDESESEEEEEGTVDEEVGESAQLSITETCLEKVSECNMNNEQRPSGERETGTTEEKQDQEEEKEEEKDEGKTFTTSSEGIKADKTDDNKGEKTTENGEKAETEERVEAETREEHEYLGEDGTGVDGGVEEVEIVTRDEELENKYDGDVEDGTTGGGDEKEEEEEEGEEKEDSCGKQGTELVDKKPSYDDQGETESPKYVDQESEERSAVVTHSQITPPTPFYDTTNIGHYGQGEPNAMSESGNSQPAQNEIKSSEENDDGVNKGGNSEYHQDKVTRTGDKYDDLERNNGQYGMSEGSDDEGDKSDPHSVNMREKEQQKEHAQNEMSENEDEARVPYVNDENTAAQNEESADVDTSGIPETFITQSAQDAGSHRERAYSTDKNGKDIDVGSQDRFSDNEDKKDMPNNDNVEYMRTEESRFSNNEDRRDMSNSDNVQFMRTEESSPEEANTIPKADDFEHNTKHEVSYNHYDQNVESNKEEQNPMSTEHYGQDAFTNKEETNEMPSEHYDQGVVSGNEEKSNITTSQHTQKAQTEMLEQKGTDHTVPDNNDFSAQMETSKHDDDYDNVAEGKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXF1</accession>
    <name>A0ABM0ZXF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sorting nexin-25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936489.1">
        <property type="nucleotide sequence ID" value="XM_013081035.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848739"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF48">
        <property type="entry name" value="SORTING NEXIN-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="90"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="386"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="613"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012936489.1"/>
        </source>
    </evidence>
    <sequence length="964" mass="110971" checksum="6DC26EC0BEFF76BE" modified="2025-10-08" version="1">MMLLIAGSVVFAVASAAYLTGWFWTLFWLVAHIAVACLGFYYAVQWNLVCGKDYKPPVNAKQKSAIKIIIQKMLELEATHREQPRKVVISRSLDNAIQEVLDLVSRHSILTWYEPLTQDKTFIKYAQMEMWNVVDLVSRRLSEVDLVKFLSQDVLDCLHQHFRSIRIAKRDPNADKSEEETNKFMLHFWLRDEERELECLRKVTDALLITLLSRPYAMCAPIRHLLREIIAGSVLRPTIDMICDPDYINLKILDYMAYREKLDADTKRTYMYSATYEGFVKMIKASDSPSDLRQMRYNIISEILQASAINNLKKQQGLNTDKDVAPKGTNKGELLKARNLERYKNQLTVAKQLCEKRLVALGETIYDTETQTSSTKEEIPGQKVFSFSVIMEMPQGREYFMKFLKKEGAESYLGFWNGVDKLKSTAKDQRHHAASELYQQYITSTSSLVRVDKAVLKSMEEFLRGDKGPDAFLIAQKDVQKVLEDQYYPSFIVSDTYFQLAASQREGVTSDDESVASDELFLDSTTEHYDDEEGLIAGQSYHAQQQLRALDSKITNKARALMAQRSSQKTEVNAKLQKVHEDMEKELESLKQERRSLEMHIARTQKWIDHIGQWNVLVYDASAISTEEDKKVAQFVLLVSLSAEGQLSPKQSSGSTEGWAISRTLDDFHALHEKLSPISSALQKKELPSSSKIFKSIDDAFVQKARVTLDEYLEAVLKDEKVIPSEALYAFLSPTPEFVYQHTNSEKKSKFSLASLMKSLPNIRSDNQDNEDDFMFGGEDSTREERSTDSIAKPLYRFVGEVFELQGVFRWFRRSLMSFVELTFGRSIDRQLKATVDWLVSEQMLIYYTQTFKDSLWPDGEWAPSAAARNDAQQQEDRMRAKTKLLENMPDILRTMVGEDNGRRGIIKIFEVLQNKNLNKHLLYNLLELLLTELLREFRSAKSTVQKSMEDQRQKLALEQETDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXJ3</accession>
    <name>A0ABM0ZXJ3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3 7">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101857942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3 7"/>
    <dbReference type="RefSeq" id="XP_012936552.1">
        <property type="nucleotide sequence ID" value="XM_013081098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857942"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012936552.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="39622" checksum="12AA1EF6FF946FEC" modified="2025-10-08" version="1">MSTSRFAEYLCPDKLAELADIAKRLTTPGKGILAADESVSTCGKRLQDINVENTEDNRRKYRELLFSTDDSLSQNISGVILFDETTKQKDKNGTPFLQILEQKGIIPGIKVDKGVVPLAGTINECTTTGLDGLKERCDEYKRMGCHFAKWRCVLKITQYTPSYLAMLENANVLARYASICQQAGLVPIVEPEVLPDGTHDLGMSQRVTEEVLAFVYKALADHHVYLEGTLLKPNMVTAGQGYTGAKPSPDQVATATVQALNRRVPPAVAGVVFLSGGQGEESATVHLNAINKCPLRRPWALTFSYGRALQASVLLAWGGKDESIKAAQEQLLKRAKANGLASVGEYTGGMAGVAGETSLFVANHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY53</accession>
    <name>A0ABM0ZY53_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011501</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936917.1">
        <property type="nucleotide sequence ID" value="XM_013081463.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011501"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047397203" evidence="1">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936917.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34745" checksum="90D0E5BF8FEF4759" modified="2025-10-08" version="1">MKMLISLSSLLLVFSVLERSRGQRFPANSSVNLTADPESWKMIPGEDSDTPLVLNCKYTGTREVLSIAIFHMTRPRTMVARARNSDGELDISKADDVTIADGSLEGDDENAYLNVVFENPGLDQDGTYACVVRTSRVVGQWPIVGYVTVEVSQVGLEEMLGGFQVLQEEIAELRAELFRPTCMVNKQVNVQTGSDKQVYAQTTLYGQHTATLNAANETEWTNRKSQTKATILDWFPGQPDSATDVKGCVGISLDTDTDSDPKMWNVPCNYVSDSNKYWAHSFLCEVPNRLNIYALNACFRKPPAQETNPLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY55</accession>
    <name>A0ABM0ZY55_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBCC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936921.1">
        <property type="nucleotide sequence ID" value="XM_013081467.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845317"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039589">
        <property type="entry name" value="TBCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052:SF0">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="321"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012936921.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="64716" checksum="484574072DA53E74" modified="2025-10-08" version="1">MAASLSAAAGGTAVSLWVKAEPFSYGTIPVAPHPRLNSTNIKKIVIYSKNKGRAGFPNLSYSVWQHIACNKLHLSEDLAWMYFHTCKFFTENPSPIESIERDELTSTRKDQPDKARCQESVNLYKFVIYLSMQQLYRMSLRTSLVAGDEWPSASSSNSTCDLDGRCTPRGGTTKSLDDHSHLLFVQNNIGELVDLLAEEDSKMSGVGVASQQTSSLSLEAVEALSFILVGRLESSQALIPFQDLACLQTVQHRSGFNKAAKTFSSRQFTLWVKDSLVQNPFNVSACIASGTRLSWPFLGEDHKAEQSHKRGKIATNAHLVPKEHVKGNKMIIMSQVSKQTIARSSGTLEMSTVKIHRSHHSFLYLLSPLRSVTIEKCRNTTLILGPVEATVHVSGCENVTVIAPCRHFMISGSTLCNMYLLTPHRPLLLSGNDTIMLAPYHTFYASLEEHMTRAGIGVVPNLWDQPLCIGPDHRDDQPVWQILPETEFYTFSVPFEIQGSTKSLPCSLPSRYQKELNKRQKQIDTWQHMVKDAGLTRDQRKEFQALVESRFHIWLAETGHKQELDSLVVPLQSTLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYV0</accession>
    <name>A0ABM0ZYV0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit TIM16 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101848584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937363.1">
        <property type="nucleotide sequence ID" value="XM_013081909.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848584"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012937363.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14866" checksum="406C6E347C66F6CD" modified="2025-10-08" version="1">MSVGPAAKYLVQIIVAGAQVTARAFTRAVKQEYTASQQAAKNAGGGRHGARKAQADTVSGMSLQEAKQVLNISDITEHESLLKNYEHLFEVNDKSKGGSLYLQSKVVRAKERIDMELMNMYKTQQEKARKQNPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYW1</accession>
    <name>A0ABM0ZYW1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myotubularin-related protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937389.1">
        <property type="nucleotide sequence ID" value="XM_013081935.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849456"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13213">
        <property type="entry name" value="PH-GRAM_MTMR14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039802">
        <property type="entry name" value="MTMR14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039803">
        <property type="entry name" value="MTMR14_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524:SF2">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937389.1"/>
        </source>
    </evidence>
    <sequence length="666" mass="74072" checksum="9166F38A70D456F6" modified="2025-10-08" version="1">MESERTAEVVQEDDIGKLLGHFAKNSHRVKTADIKGETIMERCTLLFGKDYKFTIVPNFNGELCGHYPMKLIITEFERDAVSSTEHVESRHNQQLLTQRIKNARCARCRSRFVIPVIFYQGKHICRSATLSGAAEMFGRSTTDYLLSSQSGSDAGRLDMFDKFRGHDIQLLKYFDVGYICDLMVEKKKTKFGMPITSSEKVDKENRYSDFSILCMPYPGCEFFRDWKNNSYLGEATVYDWGQALNDSKLDLPNSALVENLNIEWFKYTEWSLTELTQNYLKLLFQYIKKGDSGLLVHCISGWDRTPLFISLLRLSMWADGVVHQSLSPTEILYLTLGYDWYLFGHDLPDRLSTDEEVMYFCFKFLKDLASDEYSVLPRTHVNGNSSPTPQEGVNGPRPLSTNQTAPQHTRQGSDTSLGIHGVLLADELMTFPAKGSTSSLNSISSMEAGINFTLGVHEEEEEGEGETIDAGAEGDLPPLNVNLSHRRSLSPASRMSPTMRHSSPVSAAGRRRRSSDGQPLSVHSNHFVGSPLARPSSPMQVPQRDASEGVQSSYPNSVGSWQIIPSADNLRSLATNSSNSQSSAGRSSHVSSCHDALEINMSSTRWQRLDAVSRIFHTAYASSVQSKNVRQSSGSGLTSFFDRFAEQVGLKGAKSHGASGVSRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZN6</accession>
    <name>A0ABM0ZZN6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sperm-tail PG-rich repeat-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937839.1">
        <property type="nucleotide sequence ID" value="XM_013082385.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856263"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF60">
        <property type="entry name" value="SPERM-TAIL PG-RICH REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937839.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="63012" checksum="9CDAFB2BF38DB521" modified="2025-10-08" version="1">MYDRAPRDLSFKLGSTPNVVGPGSYDADSVTKTRLRQDGYAPFLSMSSRETFLNVSDQVVAAPGPGHYDVNLLQDGVKGGASLANRSKRFDKNASETPGPGAYQVHKHLETARYAKSAPERGAAGKGLLMTSRIKFHRKPEAPSIPSQGQAYGYEECDDGSLKKQDAPNRDQSIGPAYYNPNVPDGKSTKAYKGVHFGKLSSRRMDFYGKAGPGPGDYDPFISTASKAENANVQSEENFRYESRLPRYHEMITRDEEKKAIPGPGAYETKSTFLAQTPTFNPEGIEIEHPPFLSQAKRFSPVKSNAPGPGAYNDPRGALDSLKRVSGLKRSPFSQTAVRFNPEQQMKRAPGPGAYNISGMGAESMRKAYLEATRKGVFGTTSSRAQPMARKDEPEVPGPAHYQVKEKPFKSKYQQMGSNFASVTTRMKDLELDAPPPGSYDVIKSYEKSQVKPPVAKPRSEAANRKHGSFMSAASRFAPPRDVVVHKPDLENPGPGTYDTPREALGPKGGLMVTRDKRFRHEKEDFPGPGAYELSPLIQDTVLRGTFNHTLNNPVMPAVDAPHAMTNAKHAFLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A036</accession>
    <name>A0ABM1A036_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Disabled homolog 2-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938103.1">
        <property type="nucleotide sequence ID" value="XM_013082649.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853236"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04013">
        <property type="entry name" value="C2_SynGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05136">
        <property type="entry name" value="RasGAP_DAB2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021887">
        <property type="entry name" value="DAB2P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057606">
        <property type="entry name" value="SynGAP1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12004">
        <property type="entry name" value="DAB2P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25321">
        <property type="entry name" value="PH_RASGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="224"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="5">
        <location>
            <begin position="406"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1739"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="969"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1286"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1317"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1461"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1528"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1578"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1739"/>
            <end position="1749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012938103.1"/>
        </source>
    </evidence>
    <sequence length="1771" mass="191875" checksum="9DE39BDCF2723887" modified="2025-10-08" version="1">MSRALRKRLKSRSQHSSLERVDGGERRGSLPLVSTFTDSMDSVSTTSRLANFFSKKGFKTNLKRTKSATKLDRKRSSPNLAENNDTSSLMGSLKRTMSLGRLTRKKHGKGGAKGGGDPYGTPPSGRSPAFLSPDPASSTSSSRLPTPHASPAASLINARLRSSRSHESLLASPPSMHSIDLSAPDVEVKPLHSSVLGQGHCFHVSTAQGSKYISCTTSEERDKWLSSLRRTIRPHEEHSRRSDSSLKLWIVEAKNVSAKKRYFCEVRLDQTLYAQTSVKTMTDMLFWGEHFEFKNLPVVDIITVNLYREADKKKKKDKNTLIGYINLSISEIENRQMIEKWVTCSSGTVGKAGKETKSENPIIRLKARRQTVEILPLEAYQPFIKYLTSEYQTLCDMFEPLLNVKVKEDFATSLVHIMQKQGKAGQFLSDIVMEEISRLDDEHLTFRGNSIATKAMEAYMKLVGEKYLQDTLAEFIRQMLVSTDDCEVDPAKVGNPQILACQQKNLDMYCNMAWVKIINSFCYFPNELREVFSTLRNRCDDREKEDYSDNLISGCIFLRFLCPAILYPSLFNLTQEYPGERASRNLTLIAKTLQTLANFTQFGGKEEFMTFMNTFVEREAPNMKTFLHKISSRDAGNQFLEYDGYIDLGKELSVLHSLLLDCMGKFPETSDKKFERLSNILNTVSNAFDDPTVGLKKPNRKSQIYDNLVHVPTTARDMAQQTPNKITYGPARMKNMTASSPTEVLIDMLRHCGESADDLPALANRGRQGERTNATGEATPSTASSRGTSKDEEDSGGGGGRAVGDSWSQMVNAADSVNGDYIDLIPFMDEDVQNSSLEMEATGSQVSIGQVSTVASSGYQSFSHSQSQSNSPVDPSSQGDSTREMTRELSRSPIIHYNPGQTQPLAFANPLFRHQQQQQQLQQQLRTAPASAGIRRGSGPGSLGSHQGMPISQARTMRRRSSDSSVSSEEGDGGVDADEGDVRRRQTQPVKLSAKSSSKSANSSDYHSSIAPLKKLSQLSSSSSEEDSLNMKGSASYGGGGSSGSFVHSSSSNFISPSSASYQSSSKTSSSSSGGGSGTTSHSSSLSSALGGGYNGCSTFPRYHNRQQQDKGGGGGGGNNDTSPPLPPREAIIPSTGSGTVGRSGNFHRQFSQPQAGSHSPSQGPPPPRPLPQRGGGITTNQAGHVQQRHPMQPPGGGGDPGAPRVGVAYHMTSSPAIAPRGFHSTSGSGQSSPSIHHRGSGVGNALAGGLSSPVIYRNNKTTNNSINNNNNNNVADDISGNLAVSSSSSSNNTPTNPPASGQCSSNWQVAQHVERSSSSQDTSSSSESSPQSLVRSAQHTASASSMHESSSAHSISSAPSSSQPWAYTPSHSDSNSSLSSLTKPHQRVPVRSDSSGSLGGGGGVGQVSRISQTPSDSNSSVSSGNNNSSTGGPTAVTTSGGNSIDNFASLTHARPFHSHPSPSAFQARLSSRSDSHLNTSASSLQNKPQPPPPSFLASSKYSVVHPPVPAAHGSPRSEHVASDPALNPNRPSYPPSRSMDLGYMKRASTDSTLSQPIDGLSPTGSGPTFPLPRDDSSQSVSSATGSSANRRLSPQSAVHMGISSVQRKLQEQERTKQEYEQEVHVLRQQLLEAQERLQHAELRLLDHEEDTHQLLDEWQSRLVESEEKMRRQQEEKDEQMKTIITRLQSIEEELKREHSEMSTAVEHKQQVIEVQEQRIRTLDQANNKLLQALAELKGRAAQEREGRRGSSSCNGVAGQKEVAGFKTSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A093</accession>
    <name>A0ABM1A093_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC101860814</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012938193.1">
        <property type="nucleotide sequence ID" value="XM_013082739.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825779.1">
        <property type="nucleotide sequence ID" value="XM_035969886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860814"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="220"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="111"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012938193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035825779.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55069" checksum="1F6DB221BF36C1F7" modified="2025-10-08" version="1">MPLKGFFRKPKNSTSSTKSGEDEVTMSIGQPFNFKQNFHVGFDKEKGSFVGLPDSWQNILSTSNITQREQEENPEAVVNSLKTYTRSIKRRSSTAKFMVVATTIRESDELLDSDERSSYGSEKSQETPTSPEVETTEKKDEAISLPPVSPKPKSPKAEPAKDGAAADEVSDGMASMSTGDEADGEVLTRRPRSQKKTMTDKEVNEALKKTASPGNPQDKYDVQKKLGQGASGLVCMAKCKESEEVVAIKMMDLNQQPKKELIITEIEVMKQYRHENIVNFLDCYYLEDELWVVMEFLDGGPLTDVVTETIMKEGQIAAVCRECLKALEFLHNRNIIHRDIKSDNVLLGMVGAVKVTDFGFCAQLNAEKGKRDTMVGTPYWMAPEVVSRKQYGNKVDIWSLGIMIIEMLEGEPPYLHETALKAIYRIATKGKPEIKDEHKLSPELKDFIDKCLEVDVEERACATTLLQHPLLEKSMPLATLRPLISAARNAMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1S3</accession>
    <name>A0ABM1A1S3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012025</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939074.1">
        <property type="nucleotide sequence ID" value="XM_013083620.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012025"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047354076" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939074.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16771" checksum="33ADEBFB0D8C0FC2" modified="2025-10-08" version="1">MEFGRFLITASFLGAFMLVVSAETVKPPAHHRDGIFSLGDKNNDSILSLPECTQVWSTFDVDSDDMISKIEFLFRWRFSNLNDAKHAPLFFRLIDVDFDGSISKSEIEKLCKFFDDDEDGRISMFEYDLTWEGLFNFIRTDSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2D8</accession>
    <name>A0ABM1A2D8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Galanin receptor type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106012119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012939434.2">
        <property type="nucleotide sequence ID" value="XM_013083980.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012119"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012939434.2"/>
        </source>
    </evidence>
    <sequence length="106" mass="11429" checksum="8F7529F6943C8C9C" modified="2025-10-08" version="1">MNLAQALTTDWTLGSLACKLVPFFTQVSIAANALTLCCMAAERYLAIVYPLKFTSFHTRQRALAVLGLVWLVAVVAAGPHVHFYDTDTLCGALLAGGHCRPDAKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2I3</accession>
    <name>A0ABM1A2I3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD finger protein 7 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939537.1">
        <property type="nucleotide sequence ID" value="XM_013084083.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852028"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051188">
        <property type="entry name" value="PHD-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059102">
        <property type="entry name" value="PHD_PHF7/G2E3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420:SF42">
        <property type="entry name" value="G2_M PHASE-SPECIFIC E3 UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26054">
        <property type="entry name" value="PHD_G2E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939537.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="53525" checksum="D418EA7E36393E9F" modified="2025-10-08" version="1">MTSPCHSQSNRVCLFCRSASVDEIDLGKIHEKVDVTVHYFCMLLSSGLTQNTRVSDKKSILGFTLSDIRKEALRGRRLKCCFCKSKGATIGCCVKTCKKAFHLTCGRQNGTMHHFFNDFRSYCGDHIEQQNFAVRKSGKKSCIICLGALSTLQAPDTLSSPCCKAASFHRRCIQQYALSAGMHFFKCPMCNAVKEFQAEMMKFGIYIPDQDASWEKEPNAFQELLERHDTCDAESCLCPRGRQHSESVGQYMLSLCQNCGSFGSHKACGALVRKYKNLVCPPCSEILEESEKKRRSEGVKSISKVVKKSAVQRVRKRDSRALNSQFDRGYRAPEVFETSSVKDILLLARVNLNWESMINRCVLQCTKIDQELPLTNGKINVSQLQLDTLGQCVQCVGGSDDFQRGEDDPMCQSAKKSAGVHTVKRFTKLQSVPRDCSNILEIRYVCNLRGTFFGDGLDKESDKENIMLFGPELEPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2U5</accession>
    <name>A0ABM1A2U5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939704.1">
        <property type="nucleotide sequence ID" value="XM_013084250.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853467"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21983">
        <property type="entry name" value="HMG-box_SMARCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46232">
        <property type="entry name" value="SMARCE1 REGULATOR OF CHROMATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46232:SF1">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="79"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="79"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939704.1"/>
        </source>
    </evidence>
    <sequence length="608" mass="67804" checksum="A2A1DB9DA4A98F22" modified="2025-10-08" version="1">MALPNLRGGTVVASPVPHKSKPTPSTPSGSEKPEKGSTPFLPSPHGHPNFNPTKSRGTSSSSKSSGQSEGRLPKPPKPPDKPLMPYMRYSRKVIGKVWEQVKAQNPDLKLWEIGKIIGQMWRDLSDHDKQEFQEEYEVEKAQYTEALKAYHNSPAYQAWIAAKAEREAVDEDEPVTRPERPPPTTHKPSSKGEGSRISILPTDDEDDFEESFTTKHIAQARYLRNHRLINEIFSDAVVPDVRSVVTEARMSVLKRQVQSLTMHQKKLEGELHQIEEKHELKKKKFMESSEGFHVDLKKLCESKPQITEDMFNNMVTKAVKEETRQRQQQLLAQQQEEERKKQQPQQQTQPQQQQQQQQQNPVDEEAVKSEVEAAGATMVGTPPDSGMPPVPGPEPMEVDKDAEAAGAPQVNGNDSQVSMPQVAAPVVLKAESLPPMAATPSPPPVLPAVVAAEEGSTQVPTTTTPEKSSIGSPSTPSTAGSEREWNGEKDAGTWKPKEKQTGKVKKVKTPGAPSGKRDKIEKSDKNSRKFICDVCQKAFKQRHHLTEHKRLHSGEKPFRCSYCDKRFSHSGSYSQHMKHRCKYIETAMPKDEEEALALVGSLQPEQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3V7</accession>
    <name>A0ABM1A3V7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101854180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940297.2">
        <property type="nucleotide sequence ID" value="XM_013084843.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854180"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ORC1/DEAH AAA+ ATPase" evidence="5">
        <location>
            <begin position="163"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="NWD1/2-like winged helix-turn-helix" evidence="6">
        <location>
            <begin position="388"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1633"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="940"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1357"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1722"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="948"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1306"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1322"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1366"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1722"/>
            <end position="1748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012940297.2"/>
        </source>
    </evidence>
    <sequence length="1759" mass="197434" checksum="2BCDAD273B08FF1C" modified="2025-10-08" version="1">MREENPGRKNVTADFYRWSSVVKEVEEGILHCYSPRSDTLCLMMDVDQAKDEPGANSSPIKRLRHNVHKHYRQYASMGNLVNFKTGKKTLTYLRSLADTFIAGVASLLKAQMRQREYDVAQQLTEGSEAIQHVRIAHSESDNCKGNDATLEQVKSLLDLSKSDSKIVLLCGKSGTGKTSLAAQIARSAVMWEPRRKVVFRCLGMTLRSSSLFRVLESLTKQLSFVYSLALELPVDLTSQEAVSLFCSTLKSISEKRTLCGDLLLVLDQIDRLPDLEVHFLLCILNSLGEGISLVLTLQSPHELLNVLKSHPSVKNVKLLYMNKVEITECVTSNLHASKRIVTTDQLHQALKTLPRDPIPVYAQLLLHLLKLWPSHSLPEFEKFKNDPQSDCKALLASIEGDLGKAFSRHALSFLATARHGLAAYELLHLLSTDADILNEIKEENGDEMSVVEGFPYQLQLSKLVSRLGKFLVEVKIEGESVYRVMCQPLIDCIKSRYMSERFSQSVHLRLANFFQFIRRGLLLSSRDISEQKHQRLSKYHWRTLRCVPFHLCFISSSTAEVWSALKEKVFFNFAWLVNAVYSGFFNDLLDDITFALDVVSLDPDIQYLRQLLLSVRHTVIHNPTSLAAVFSSQKVDDLHNMKDSVKSVVEEARVWLKQVHLQALVPVSYTSDKTSRLLVKENGIFGVKALTSVGDTGTLLVQRDKSLLRHNVLTCEEMPLATLTDDIISFHICGDENVCVLVRKETSTLQLEVFSLEKGRHLKSISLGDRPLLWLDIRTPNTSFFANDTAIKSLDLNRGVITNIISWQQSFTAACISTSKPERVITVNVDKKTTIDYAPVKNVSAFKELTLRNEIPNKHCCILKSTKDGKYIVHVTERQALVVEASMFKVHETFSLNGLPIVMAEFSRSHEHLFLAYANCAITCHILYSGTEAMNTKLKPKPKPRVYTSHTAARQSRMSPRTGGSARMIAETDTIISMLTSEDDHFLICGTRLGHAYVIHVPTGQQLVDITTGQKSINTLIFLTDRGHFQHLITGDSMGNALHWNLRPLIKQTRLLLQPYILDEDLYKEEEAKLELDAYHRTFEAKRNNRVFLNGPDIAAFYTNPPEDTLHVLMELDPAFAVQQDWEMSGSLENLTEQLVAIASGQELGDMLLTVSADLRLARWSLHDGGLMWSKKLPREGNEVQALVSVYYDQAALVVAKFTGRQTVTLMVIYTGEGQTKTMIRRDVTAYWISRDNTKIIMMCEQPQIEDKRLFLWDLINGQEETWQFSNLQKLGDDASQQCPFFAAFSPSLNQCIRVDVPPPESTTTHSPHPSGFDGRRSQGSVNSNRPVGNEGDSPFAVDGQLNESFDAVENDRFTSEDARSPANNSKQPISVESNVGPAAAADSSRGSRCPSRVSETPQPRPGSGDQNKSVFGDDDGLIEKEIERKTTIHWSKGKMDPKPEQETLMVPRFDKLGRRNSWSITSRAGFGSRSRIPVEYFPRRASLHIDGSGKLVPENIKTNGGDSPDDVTETEPTEANFTLLVTMSTISFVSDEHVLVGTTTGHVLVLKINSFNTFCVLGVNEDPLLLPADKNNITLRRISPPHEAAVTYVASSTDGSSLVSADNSSICLWDVATRMLKMEIRLDPGQQITHLQISKDANLVVVATNDRTLRLWSPVGLREIANYKTNFDILDLQMTSDCRKIAVQGVGQEDRPVLEIFEVKNIDDVLMLVAERKKSHQHEVSENLKDERKRRASRRMSEMRRDSLPPAADLDLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A402</accession>
    <name>A0ABM1A402_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012315</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940360.1">
        <property type="nucleotide sequence ID" value="XM_013084906.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012315"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045782100" evidence="2">
        <location>
            <begin position="42"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940360.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="37291" checksum="2F622748439E22BE" modified="2025-10-08" version="1">MGWTLVGRWFGGTLCSFPGIRFVLFWTVLLLLSCFVPTGSGSADDLYPDPDPDLGPNFSSALTSEGSGHGSFLDALGFTDDEDSYNYGGGDYGDSYDDTHIHIGDLTIRCFHCLGDGNTGCDVVAMLADVEKHTVMCLGKCLNISDGPTAVYNCANDMSSRFDTCLENSGTQMCFCSGDYCNSPGTDIDIFRSHDPALILNADEDNNNGTDDIFNIRGGSVNGSNTDQDMMGSDQNQTASSNEISLGSNPSLSMNESHKFKHRHPLDRFPFLFKTETDVIIPLRSSGGDESSNSFEESSSSVSVNSAAVGNLRDKDAESCAPLRASYIPSLFSISIIALISCVRFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A483</accession>
    <name>A0ABM1A483_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent helicase ATRX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC101846389</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940516.1">
        <property type="nucleotide sequence ID" value="XM_013085062.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846389"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11726">
        <property type="entry name" value="ADDz_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041430">
        <property type="entry name" value="ADD_ATRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17981">
        <property type="entry name" value="ADD_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="83"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="1476"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1912"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="223"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="392"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1802"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2323"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="574"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="712"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="809"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="824"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="908"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="975"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1084"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1115"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1136"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1159"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1183"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1199"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1227"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1259"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1271"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1292"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1313"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1332"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1351"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1372"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1384"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1838"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1862"/>
            <end position="1879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_012940516.1"/>
        </source>
    </evidence>
    <sequence length="2343" mass="261616" checksum="3433B3D49F01FF88" modified="2025-10-08" version="1">MASLFKSGSSRSKKGEAPGKLRIVMKGFSAKSKGNDKEEDSDNSEMEDVSDSGVPEHQPEGNVAVEPESGEDAPVKKKKEAPVRIDTSVLDNVSCTACGRQLNPYKGNALQKHPALKVVICKRCDKFLSSGDIAKDKDGIDEQCRWCGEGGRLVVCDECSSAFCKSCVMRNFNRSEFNNINGQSKWRCYLCDKAPLQGLRETYRNIRDTLKALQARDKAKAAAAAASGNAQPSSNGTKRTGKSNDAELSKSAVSTSSSSSSAKKNVQQDSKAKNSASSKEAADSKRGSASPDNDQDVALCASDLKTAPENVDVVMDKLSTATSTFKEMLRALRSQFHSTSPRADEEDATPMFHFSLSSSMSVTEKKRCCAKALNSSLHTYVKSLKAILTASDSKGQAQDSFNTKTGADSAEQSESATTTSEHQEDGEKSLTSASAKQQSNSAEKATAGRKTISRLPFTSSTSSKSRAENVSSKVSPVSMNGTDSDSRQDRVSSRSSEDLPNSAKKSGGRTRNRTGLDSLSDDSDDDSSKPKPKEKNQSSHKSVSSLQKGSTESESLKSITNERGSTRLSLSRTAGKEKESKDSSEKSVEKDKIESRKSREGKESGEKDKIDPKKSKEGKESGEKDKIDSRKSKEGKESGEKDKIDSRKSKEGKESGEKDKIDSKKSKEGKESGEKDKIDSKKSKEGKESGEKDKVDSKKFKEGKESGEEDKLESKKLKENKESEETGIEKDKMTTKKSKSKDVLEASGKPSETEKDSVPSGADTTELLCEDSWSENGVSSPHGEVASHKNDAGASCDNEDEENMAAKFDLIKELADEMLKSNEEAEEKEDGGDGEKEEEEEAVSDRSDNGEAEDEVASNSRSKRKFRDSDSSGEDKSRLKKTPKKAKKRSNSSEKSSKGEEKDDENDDARSDFEKVSDGSDSNQVKDKEKADEEQAKDSVAASDDEASSSDVLMSSDDNDVGTSTSARRKKKNKKELTASKEKVQKPAKETKKVSKVSKKPVANGTDKPKSAASSAVKSKPKSNGKASKGDSKNAKEDEEEDEDEKEIEKLSKMPVMRKRKVKDTPEEVEEDVSEVKSKTSKPPAKRNKPGPKCSKKNMDFEDLSSDGDDAKNDEIDEEEEEDDEDEPKVTFFLEEPVEQQDGLEVDEENEMAKNGLLDEMDSDKAEEDDKDSDDSSLDEFDEPQKSKKKDEKKTSSQNEEDDEKEENDDDDDSDSPVGRKKQIRSKLLDTKLSDSDSDIGKSKKKKKEEDETFKTGEEGSSSGSSIESDLPSEEESEKDSDEDGDNSEPKSKKKGKKKPRKRKGKKKKKGSDDDEEDEEQEDDDEEEEGGKKKKGKGKKRRRIKKIANSSDEDGEKGSDSDDDDPNSSQAGKRKKIRKVMSNKKLEDSTRAAARAEEKRRKRIAAKQREFNIETITDENNPMNCLITTKLILEPGKEEGDEPIVQVNKKLVRKLKPHQVEAVQFMWDCMYESVKRSKKEQGAGCILAHCMGLGKTLSVISFVHTVMTHAKVLGQRTCLVVSPLNTVLNWQNEWTMWFDEEDQLEVWELASCKQNPLRADTLKDWHESGGIMIIGYEMYRNLTTGARIKNKRQKKIFYETLVDPGPDLVVCDEGHILKNEASALSKAMNQMKTRRRVVLTGTPLQNNLNEYHCMVSFVKPNLLGTRKEFNNRFISPIGNGQCTDSTPRDVKLMKARAHVLHEMLAGCVQRRDYSALTKFLPPKQEYVISVRLTDVQADLYYKYMELSGQGVDGVFNNKGARLFKDYQNLMKIWTHPWVLKLAEIRDELKMKYDDEDSFIDDDSLDERSFSSSGSSSDDDKKMSDSGGEGTSAGAGQKRGTRRTRAKARRQAGEDSDPEEVITEWKSKTRGPDEDGRPEEPENQVSSQWWAQYVTEDDKSKLELSNKLTLLFEILRMCEEIGDKVLIFSQSILSLNIIENFLENIDSKFQQECDEKPEGEEEKPEEEMFGRQWTKNLDYYRMDGSTSAQNRQAWAQSFNDLENYRARLFLISTKAGGLGINLVAANRVIIFDASWNPSHDVQSIFRVYRFGQTKPCYIYRFLAQGSMEEKIYERQVTKLSLSQRVVDEHQIERHFSASDLKELYNFTPDRWNDGKDKPTLALPKDPLLAEILTNNKQCVVSFHEHDSLLENQIEQTLTEEEKKAAWEEYENEKKGIIVRGPGMERTASWPMMAAAQILSREQITATVQTLRQQLPDVPEELFQLHVQQALRRMVQLKQEEMRRIELMRIQEMNYLNMMKQEAQQQGLTHAQSLQALQNMQSMAAAPWMQIQRLRAMQNQMLQQGAGGSGMMNSAMMGNLMGAMGNQRLSNKPEEAIDLDAPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4P1</accession>
    <name>A0ABM1A4P1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012409</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940780.1">
        <property type="nucleotide sequence ID" value="XM_013085326.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012409"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047197339" evidence="1">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940780.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15325" checksum="AD136843EB1DB9E4" modified="2025-10-08" version="1">MGCKDLLVWFLFLATPDWSLSSEANQLNAALGNSNQPEALIAAQNIVNQSVSAIAKQGKPVEKQAVCVQPVFSLCNPFQPNQCCPFQNQLCLFVGLATTSVPICFPCGARSQFCVPGATPGFVGTCCPGLVCGGIGFGRGVCLNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4Q4</accession>
    <name>A0ABM1A4Q4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine-rich cell wall structural protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940797.1">
        <property type="nucleotide sequence ID" value="XM_013085343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853428"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940797.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="31404" checksum="1B066BED92031BEB" modified="2025-10-08" version="1">MTSKVPRGHRRRSSERLTERFSRTQNHDEATLILDGGPLTDPTHLTARRAQSACTGTQIPVMAHLLSFAFLSAVLLVLAEATFIRPPMFHKRGFFPGFRPIPVPLPSFGKIIRPGPGPGFRPRPKIINNNNNRRDLIVVVNDRNGGVGGGRVIRKVVGGGIGGGIGGGIGGGIGGGIGGGIGGGIGGGIGGGIIGGGIGGGIIGGGIGGGVIGVGGVGGIGGIGGVGGIGGVGGIGGIGGVGGVGGIGGIGGVGGIGGLGGVGGIGGLGGIGGIGGGINNGFGDGFDPRDVDGRRGMLRGQSFENGGGRYNIHDADTVVIGGNGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A507</accession>
    <name>A0ABM1A507_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">C-Maf-inducing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC101863917</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940950.1">
        <property type="nucleotide sequence ID" value="XM_013085496.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012940951.1">
        <property type="nucleotide sequence ID" value="XM_013085497.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012940952.1">
        <property type="nucleotide sequence ID" value="XM_013085498.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012940953.1">
        <property type="nucleotide sequence ID" value="XM_013085499.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863917"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052813">
        <property type="entry name" value="CMIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056429">
        <property type="entry name" value="PH_CMIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25480:SF0">
        <property type="entry name" value="C-MAF-INDUCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25480">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23066">
        <property type="entry name" value="PH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-Maf-inducing protein PH" evidence="2">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012940952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012940953.1"/>
        </source>
    </evidence>
    <sequence length="680" mass="76943" checksum="891F5D490C9CC653" modified="2025-10-08" version="1">MATTDCSVASSTAPSDNNNVKSVSDMSTTVQSPTSPKAPVQLGPKHKLITEADVQVCRLNHTRTIVSKIMNSRYLRRWESHRIVLDHNEVRSTTPTGFMELAVPYSSIEDVHIVSRWDAGQKFCLRITIPDGSVLLQANNAYIRDQWLHSIQWKRHIFRSERLLKNARRPEILVKEIKSMIDVSLVTPIQDSSVFRFPLDLVSDLLQDNDEFLSKEFQETIIVALTPLLEKNHPTQEICDFFSKHCKDSPRSTLVIELFTPVVHRILKHNTDFGKYPRMRTFVQEYIQALNSQNDGLRVVQALVKSMHGPASTCPHPRVLPNLVAVCLAAIYTCYEERKSNVHDNVDGEDFDQVEWENKLLCYVSMMETMSEFDDWRYVLGSLLQPIPFPDDAIADSLFTSRMKVTIHNVSSDETCGVHQTLLGIREGKEGWFHLYCPGGIACDDDGQLWGVMLNTLMKCCCKRKKFLMSISKMIGPIMLLALRDNFAAMEVLCSMLELEVVEGHDLRMQMITTLQSTTEGKRMYAQLCERQIAIKEMQQQKGGPKKLTLPSKSTDIDLTKMLSSGSFGNLECLSLAFTQVTSACANDLIKLPSLRYLNLWSTQFGDQGLQTISEHLHKLQVLNLCETPVTDKGLACLASIKSLRKLNLNSTNLSALTFEGLKEKLPALQECDVRYTDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5M9</accession>
    <name>A0ABM1A5M9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRKCA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein interacting with C kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Protein kinase C-alpha-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">PICK1</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition. Interacts with SORCS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Synapse</location>
            <location evidence="21">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941296.1">
        <property type="nucleotide sequence ID" value="XM_013085842.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848373"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07659">
        <property type="entry name" value="BAR_PICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06722">
        <property type="entry name" value="PDZ_PICK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037959">
        <property type="entry name" value="PICK1_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF1">
        <property type="entry name" value="PRKCA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="8" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="AH" evidence="26">
        <location>
            <begin position="165"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="394"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00093501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_012941296.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48552" checksum="7AB0D52F504AA3D3" modified="2025-10-08" version="1">MNSAPIDYSPVSSMDLDEIYSDQNKHHPLPWEDNMGMTVTSGHVVLKKDTQNLIGISIGGGAPLCPCLYVVQVFDNTPAAKEGSLAAGDEIVGVNGQSVKGRTKVEVARMIQSIKAEVTINYNKLHADPKQGKSLDIILKKVKHRVVENMNSNTADALGLSRAILCNDGLLKKLEEMERTANMYGGLIVQTRKLLKAIFDLSQSHKAFGEVFSGIGVREPQPAASEAFSQFGEAHRNMEKFAIKMLKTVKPMISDLNTFLHKAVPDTRLTVKKYLDAKFEYLSYCLKVKEMDDEEYSYAALQEPLYRVETGNYEYRLVLRCRQEARTRFAKMRSDVLVKMELLDQKHVQDIVFQLQKFVTAMAKYHTDCHNVMKTAVVFPIEVDLSRGTFTYDTANNFNDGEDDDDEEDDDDEMIGQELGAQGDNILTGDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6P2</accession>
    <name>A0ABM1A6P2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101853253 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101853253 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101853253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941871.1">
        <property type="nucleotide sequence ID" value="XM_013086417.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827471.1">
        <property type="nucleotide sequence ID" value="XM_035971578.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853253"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827471.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="63138" checksum="B4F1B7FAF4EB2823" modified="2025-10-08" version="1">MNSKCCNSEVTVYLQAYFVTIATILGTGILGLPVTLVNSGLYPFLITFILDAVVQSLLVHFFVDLLQRAVAAQHVEQREESVPLNTMLEEDIDLESDDGDELTNVQFTGAIMKGKMQHIREVPLVQPPNLHLLGKLFLGCGLQQVFDMLIILQFIALLVCYALAGSEAFAQLIGIDHFYVIPVFVWVLTTAIVFALSLIQPVVSVLTFVKGSLLLGTAMVTFYVGLTVAEEISNDFSYIGAPFLMGTVALGGVCNTMPYTFEKVPFKKNSISKYRLAVQLGLWTCVLLNILWCWAVLDIVPQTIAMACSNEAGLSLRRYDNDSGKMFSGLQTCYGKLSLESAEANGEISTLPLTKLLQRDHPSFTWVAILVEVFIMVSITVSYLTIGTALHHTLKGIVQSFLAKRRGSSTGKGKSSKTSAAHWFAITGVSLGAFTIVFAIAMVDPEGFVDILEKLVSFTLNLEVGLFFFLMFIWSKRNSYVHLEVPLPMSQCLYYLIYLLPVFFNFAVIYDVYNTVMDIAYPQQHQKIVFNVSSSTTVGSVPDNAFTLNTTVSTTTTTPLADNVGATNSSLNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7M5</accession>
    <name>A0ABM1A7M5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-related protein Rab-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942416.1">
        <property type="nucleotide sequence ID" value="XM_013086962.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846242"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942416.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33962" checksum="933623055070D72E" modified="2025-10-08" version="1">MPLEERNCAVTYKVLVLGHYSVGKTALLDNLTGHTFRDTMAPTVGVDFVRKIFEVDGALVQLLIWDSPGQERFRSITRQQYRGVQGLVLVYDVTNSDTFETLQYWLRSIEEEMSPPTGGYEPIPFVICGNKTDLSSHRKVTSAKGTEFSDRHMAFGFFETSAKTGENVYSAFHTLAFNITDICDPKLMKSYHPYLLRPVSLGVPRVSSPSTQRKSKLQARTKTKRTRKLATHKDGAVAMDARELRVVYAKDETALGSLHGTNFSRGGAGGSERKSDRQKEERGEWGCVLLWCCSGKKRKHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A898</accession>
    <name>A0ABM1A898_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Filaggrin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942737.2">
        <property type="nucleotide sequence ID" value="XM_013087283.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012928"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2037"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1389"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1424"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1498"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1993"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2057"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2187"/>
            <end position="2197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2198"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2222"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2249"/>
            <end position="2258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942737.2"/>
        </source>
    </evidence>
    <sequence length="2275" mass="252037" checksum="42928CF81F85A849" modified="2025-10-08" version="1">MWRLGFDSPPDYDDHQGYCGGKDALWKRFDGKCGVCGDPYFPLPRPHERGGQYYDGTPTRVYQQGELIKVTMGITANHRGWVEFRLCIYDKPRSGDLEFDSDGDFVEVTQECLDRHLLRLEDGSTRFELPEPYASREYTVNVRLPRGVSCKKCLFQWKWNVGNSWGTDHDGTSCIGCGEQEQFYACSDIVIEPRDGSSIPEEEDTPEGKGSGRRRQRPRHRNRRPGRKNKNRGRGKGKGRGHRNRKEDNDEDDEEAATKATTAATSVSTIEITATTTTSTFKPKTTTMMKDTTAHNDGMPEKPAKDEPYWWFIENIPLLFHSSLDKKDDSPDPSYYVPHKPTTESDSDLPENPKFWKWVEAFSPLFSNDKGPESSDLPGRSRWLDVQEKSAHNVHAHREMVGHEDESAGNAESPSEIPSWWDRMGSKLNAGNLKGLLGRKMRYFLHGGENQLASGESSSSIHRSRRSLPTQPTASSEGKNKDVEKSLTPISSLLSGGNGTNTAQNISQPDSVVISQAAVTPNAVDDVASHTNNSTTIQQLNAHNKAPVGRAGEEQTSNSNSQNQKKFSKSTNPVTTPTYAPKDTVVLHQEIARPGKVMSDLKLLRDASFYKEGHDKSDNHDSYRKGSSRFGKMQFAKVELGQEGVPSQNGVAKNPASRKPVDIHDTDIPVENTASKHGEKNNNQTDSEIDVTTSPNEGRWVGVPAWGRRINGRPHLRPRFRFYRRRLSLAGRGRRPRFWRRRDGHVTAERPVTVDTSNDTVTGANNNSTDSNSSTVNVSVPGTEDATLSKMRLPSTFERLLLRKQGGQEKGQRPARLQLGSETNDPRVLKTIHQTEKTIKRTDAVVVDPKDANKGNSQGPRGHVPLGHTAGQLGHPSGRGVHRSGNSQVQGSRRHFGRGKGQGYSGEATGKFPSGFGKSGLGRHGAGGDYKEGGEEDYGDYEGNGKYYSSEEGNDDFEYSKNNDGDYDYSTDSNGYGSNRNGKFGSGRKAGCDYKTDDYGDEENGMGFGGYSNGKSDYYGSDKSEPNSHRGSGGDEYEDSSDYDDSDNGGDGKWSSDHMMDGDDGNDDGEEGYDEDEYDNRHNNGYSKGRRNEVGHAGNYAGNSDCSGGEDEDYEGQGNYNKDHYGDDDYNDDGKYDKNESGKYYDDDNQDDDGDDVEGYGDGGGKYDDQDYSDDSKSGGDYGHYSEDHYSGSKSGDYEESSSGKGYWYDRSSHGDSRYAGNNNGDVKGQSGCDGAKSRNSDYYYEQQGSGEYSRGSGWEDGDAKGDYDHGDFKSLYSKKSEGSQGKKTFSGENAGHSGVNERDEGHVGKESESEGHEGGHQEGHEKGEIQDGGHGESSGHSDYEYSDYGKSDSEHRFSGHGDSGKSDFGHVDYSGHSDYDYSDYSNSDSKHGESGHGDYGHGESGHGDSGHGDYEYSLSGHGDSGHGDYEHSLSGHGDYDYSLSGHDDSGHDDYEYSESGHGGSGHSGHGNNYDWELHESHGDHGGNHGDDEHGDDHDDYDNGDEGDNDEDENHDDYDDDDGNGDYEDDEDDDHGDWDHGDDDYEHNDKDEDDDHEDDDDDDDDDDDDDDDYSGHHDYEEDDSHDNWDHGDLKLNNDDSGKYEHADEHSGHSEYGHGDYDHGDYEHGDEHSGHGDYGHSNGDSRHGDFDHGDEHSGHGDYGHGDYDHGDAHSGHGDYDLSDEHSGHGDYDHGDEHSGHGDYGLSDEHSGHGDYDHGDEHSGHGDYDHADEHSGHGDYDHGDEHSGQGDYGHGDEHSGHSDYGHGDYDHSDEHSGHGDYDHGDEHSGHDDYGHGDYDHGDEHSGHGDYGHGDEHSGHGDYDHGDEDSGHGDYEHGDYEHGDYDHGDEHSGHGDYYHGDEDSGYGDYEHGDYDHGDEHYGHGDYDHGDEHSGNGDYDHGYDHSGHGDYDNGVDGHGDYDHGDYGHDEYHHSDHSGFGYGDEHSSHSYENGGHDDYDQGDEHSSHSYENSGHDDYDQGDEHSGHGDYGDEDYDRDNDKSEYGKYKNSEQHTGYSDYDHSDIKLYQGHDDKYENYKHSGHGYGDYGHEDKHSKHGYYGYVEHEDGYHDHGDEHSGHDHYGPGYEHSGHDDYGNGDNDHGDEHSGHDDYDHGDEHSGHDDYDHGDEHSGHNDYGHGDYDHGDEHSGHDDYDHGDEHSGHDDYDHGDEHSGHNDYGHGDYDHGDEHSDEDGGDVHGDEHDEHGDDESEDDEHGDDHDDDHDEDDHGDEGSSDGHGHGEDDHGCFDPALPVNPEAEQKDRHKDSGTFTEYIVGRELMNVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9E0</accession>
    <name>A0ABM1A9E0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101862066</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943339.1">
        <property type="nucleotide sequence ID" value="XM_013087885.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862066"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF311">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943339.1"/>
        </source>
    </evidence>
    <sequence length="767" mass="83330" checksum="C690A62D8FB245AD" modified="2025-10-08" version="1">MSVPISLSAMFLDWQSDFRVPRANTAAILSTCVGVMFAAGVIPGYLMNRFGARFTVLLGTFLATTGCFLSAFATSVPYLIASTGVLSGLGFCFLQLPVLPCLTAGVTEGKSVLIALSSVGGALMNMAMPYLYRIWVDAYSWRGAFFLISGLSLNTLVTGLVMTSPVYATTPSSSALVEADDAEKALLNASDDHELKENGVKSSKSKRGTAHTGSDTKPNRASSQDENCGQGDYVDTDSRGLVEGFELASSTEKGWEMNEARQEPKILTKERSSVDERLPVTPLIRQRDLDDFQNLADFHATQSLESLDNITSRCDDLLEEEKSSLVGAQTDEQEHMNTMMSYYPEKNNPFEGDTEEIVQQSQKRRENDSDQKSGSHDLDLERSGKPTGDLQDDSVEKGSHLKHIVSNSQNHYDEGAKKSPVSENVEPATQTLPLLHDTEVAYGNELYQKEPHRSASPDNKTRSERFSPSILIRRLRLSKWKFMVDPLFVLFVANVGFGLGSFFSFFIMLVDFAKTKGFDGDKEGIFFIFLVVTTSLFARIIAGFVNLHPACHSVLIMVGFSALTSFTFLILAHVTRYYAVVCVLAVTGLGLGGVLGIFLKVPLDIPSVGTESYALALGVISTVEGIFDVSVPVILGYAVDQTGSYLVPLTALGWISLASAIALAAVFRISQRRTSISRGATPLVMSEGRSREATPPVMSERRSLEATPTVMSERRSLEATPPVMSEEGSPVPDSSTKPVKGDEIDDVSVVDSRNITPMADSTNHVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9N5</accession>
    <name>A0ABM1A9N5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H oxidase (H2O2-forming)</fullName>
            <ecNumber evidence="3">1.6.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101857144</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>NADH + O2 + H(+) = H2O2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11264"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.3.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012943483.1">
        <property type="nucleotide sequence ID" value="XM_013088029.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857144"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF208">
        <property type="entry name" value="DUAL OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047433180" description="NAD(P)H oxidase (H2O2-forming)" evidence="18">
        <location>
            <begin position="31"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1045"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1085"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1127"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1184"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1219"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="830"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="866"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="1269"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="984"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
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        </source>
    </evidence>
    <sequence length="1550" mass="175007" checksum="74A31050F875440E" modified="2025-10-08" version="1">MGSPHNNAFSVGVLLSLSLAVLFTSSCVHCQEYPTYGGFKNNKNEPTWGMAGGRFLRGSDAAYTDGAYQMAGKDRPNPMEISVAAHSSESLEASSYSRNALLAFFGQLILDEVGVASNPGCPPEYENMEVPRSHPISNSTERPQVFVRSVYDQRTGYTSEGPRRQTNQVSSYMDGEVIYGTSRVWTNHLRSFRDGKLLADVEDVRESFPVYNDVKLPFLNSPVPFEHTTKPVSRLFRIGNAKGHENPFLLALQVIWLRWHNKVAEDVATSDSSLSDQQIFDITRSRVIAHFQNIALKEWLPAFVYAKDNNQSNFPGYLGYNKRVEPDVTHEFLAAMTFRHTFTPGAVWTLGYSVGQCTRNVTQGRGPEGQARDVPSLRLCNNFWDPQNVVKVNFENIVRGMIYTLGTKEDGTFESDFIESFHGPYEYSRTDHVAEQIQRFRDHGLADYNSVRKAYKLATRTDWSTLGGSNGTISDLYGGSGGLDNLDFVTGGLLDAPSTSGMSDIFKLVIEEQFTRLRDGDRFWYQNEDNGLFNASDVQDIESVTFRDILLSTTSLTDAELPPNVFLCEGTGTTGCPCKDPPDVSDSSSPDVDVCTPLRTYDYIKGSEWSFALSFLALAMVAPVSYLVLCLLVRKRKTTKKSGAKQASTVYSSNNPSSFQAREWLGKTSGYRDVLGELVSSKEQIVIRDGRKKILRVVEFKRDPEKVHVMLSNDKDLSSAAVVVPGDIDLILKFPDFVSRNRFHLTLEKFVTDMNMAPEMNYVTESFLHSKARDKDQRQGVLDIFFRAICERALEGETSSDTLMSNDLVEQVIHIKLNMAEFADALGMQPSSLFVRNVFLLGDKNKDGYVSFEEFLDLFAVFLKGTAEEKARLLFNTYDIKKRGYLTKDEIRRMLKSIVELSESTDVSETSVDDLVTSMLRHQGLQDNDRMTFEHFRQVFCAEEFKSTLEQSTLSGEAVKHAPKIRPGIARNKRNTMIMSYIKRPNNASRPPSGENKTATLEKTTTSPFRSSLRVSVNRPTYPGSKAGKRWYELTRYINRYSRQIFWVTLYTLITIGIFVERAYFYAKGREHAGLRRLSGAWVVAMIRGSASVIMFTYVSLLVTMCRNTITALRETFLHRFIPFDSAVAFHKYIAVLAMIGTLVHIVGHAINLYCMCTQTTASVNCFFREYFTASDSFAPFHYWAFQTITGLAGVFVTILIFVMYVFATQFSRRHVFKAFWMTHSMYWLVYVLTFLHGIGRLVQSPLFPWYAVGPVLLFIVDRLMSISRNKAEIAVTSATALPSDVLRLVFKRPSSFTYRSGQWVRIACLGLSDSEYHPFTLTSAPHEPLLSLHIRAVGPWTRNLRKIYGGVSEGEALNVPNLYLDGPFGEGHQDWYTCDVAVLVGGGIGVTPFASILKDIAFKSKSGVPITCKKVYFIWVTRTQRSYEWLVDIIRDVEKMDTQGLVHSHIFVTQFRQKFDLRTTMLYICERFFQKLEGQSLFTGLKAVTHFGRPQFEDFFCSLVTEHKQVSQVGVFSCGPGPMTASVQKACTYMNGLIGPTFTHHYENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA39</accession>
    <name>A0ABM1AA39_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Synaptotagmin-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101849083</name>
        <name evidence="6 8" type="synonym">LOC101849326</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109990.3">
        <property type="nucleotide sequence ID" value="XM_005109933.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943736.1">
        <property type="nucleotide sequence ID" value="XM_013088282.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828655.1">
        <property type="nucleotide sequence ID" value="XM_035972762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849083"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08403">
        <property type="entry name" value="C2B_Synaptotagmin-3-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF374">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="162"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="294"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005109990.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012943736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828655.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="51800" checksum="369D7E33561991AA" modified="2025-10-08" version="1">MGQFAKGPDPVLVGVVVGGVALFVGFALVTTWYICRRKKGLSLLPTSHSASGTLATLRPGTPGSIPISRSHHEIGSSGPKSAPLPPSGKKSVFQIADRQWTLPTVSQRHQNFQRMLSHRLNLSHIEFSVQSVKQKEQPDLGVIKPELYKQASVDSLRSEHVPCGKLFFSLRYSQEEASLVVNVTRAENLPAKDFSGTSDPYVKVYLMPDRKTKHQTKVHRKTLNPEFNEKFSFTVLYEDLSGRSLQFNIYDFDRFSRHDVIGAVKVKDILGEGSLSKETFFVRDIYASQQEKADIGEVMLSLCYLPTAGRLTLTVVKARNLKAMDITGYADPYVKVCLMCQGRRIKKRKTSVQRNTLNPVFNEALVFDVPQESVEDVHLLVKVVDYDRIGSDEFMGCVTLGPKVGGQGREHWYEMLETPRRPVAQWYPLMEQPPLPAPSNGKCCLRQRQSTEDSVASDNNNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAD3</accession>
    <name>A0ABM1AAD3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101848692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943910.1">
        <property type="nucleotide sequence ID" value="XM_013088456.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848692"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003113">
        <property type="entry name" value="PI3K_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF118">
        <property type="entry name" value="PI-3 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02192">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00143">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51544">
        <property type="entry name" value="PI3K_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-ABD" evidence="7">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="9">
        <location>
            <begin position="198"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="10">
        <location>
            <begin position="324"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="753"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012943910.1"/>
        </source>
    </evidence>
    <sequence length="1044" mass="121271" checksum="8B5EF83328E55D96" modified="2025-10-08" version="1">MAYFDVAGLDGSPQLPSIKTEYMIDRDNNYIDVDFLFPNGILLPFSVDYFSPMDQIKSIIWREVHNYPLADNLRAENSYNFFFINRMGEREEVMDESQNLEELQPFLAMFQLVENKEDDRSKTLDKKIDHLIGRGIQKQESFQTAEINHFKQKMSEMAREITILRRAKSPMEKFQWKYPVRLRSHDFIPSQVESRIVNGAIVVDIGFGEAKMCYKLRVSHNGTPEDAVKMALNKKRTTLGTPLEDSKLYILKVIGQEEYLYGEHSLIQFKYVYQCLVKNTAPQFWMVRKDTLPEATPPVPYRPTPSPILHQDSVKSNDIIVWNIKVPYKIQVQGISKLQLADGTKVKLYVGVYHGAESLCKEKVTEEQTVQSGSCQAKTDIEFDIHVADLPHSARLCFALYTIGSTKRQDLCSWVNIPVYDFKLRLQRGDRELPMWPQDLLQQPEEHCYPLGGVSLNVLRMDASFVKVNFPDVAYTKGAYLVYPPYDKVLECASENMVSDGEVGSPSMKVSKIHLEQLAQALYQSDQLFEQDKELIWMLRYEVCQRFPNSLTRVLQSVKWNSYIEVATMTALLQTWPTLPVDFALEILDYEYPDRNVREFAVKCLDKELSDDDLAQYLLQLVQALKFETHLCCPLAEFLLRRALKNQHMGHKLFWLLKSETYNAAVSTQYRLLLECYLRHNEDHLLVLMKQQEALKKLCGLNSLIKLGNIGDQAHKEQAMQHMTKVLNQKTYKKCLSQLSSPLTPLYKMRELRVEKCKFMSSKKRPLWLVWENSDEMGPDIQIIYKNGDDLRQDMLTLQILQVMDNLWQAEGLDFRMNPYMCMATDLEQGMIEVVSPADTMANIQRWFKKTAFDKRALFEWLKMKHKSPEHLDAAVEEFLMSCAGYCVATYVIGVGDRHNDNIMMKSSGQMFHIDFGHFLGNFKSKFHVKRERVPFVLTSHFVYVITKGDTERGNFDRFRVMCEKAFLILRNKYSLLMSLFMMMLSGGIPQLSSPKDVNYLRETLVPHLSEIDARAHFRSKFNQALKGAWKTSLNFWFHIQLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAT7</accession>
    <name>A0ABM1AAT7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC106013315</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106013315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944147.1">
        <property type="nucleotide sequence ID" value="XM_013088693.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013315"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012944147.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27607" checksum="A91A497C2D32EDCF" modified="2025-10-08" version="1">MDNEKLLKAIQERRILYDKTDPKHSDREWLQREWEAVAEELNVEVDAAKKRWAYLRDYFRKQHRVLELVKIGRAPSRKKRWPLFDSMSFLLPYSKPININIDDDFDFCDAVSEGSITTDCDDENDNDDEESFKRPDTGTRSTHLMSKKRKAPSADFEGECISVDTSQKPLVDEQDENEHFLKSILPMMKTLEQLEAMEFRHEVQGLLIQYIKRARLQLPSEHTATASASSIVIKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABP4</accession>
    <name>A0ABM1ABP4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glycine receptor subunit alphaZ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101849968</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944642.1">
        <property type="nucleotide sequence ID" value="XM_013089188.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849968"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="63"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="321"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012944642.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="56239" checksum="32F823E5BC5D0E75" modified="2025-10-08" version="1">MATALSSVLHLTFILLVVVQLGCCVLDDARLRERRLADSSKPSSKEKSNGTLSDQGKPSAREAAIQRILNDHDPKIPPDFEKDFPTEVTVQVFIVSFDSISEATMDYSVSIFLRQTWVDQRMTYNKLPGVDMLELDTRVMGEVWVPDLFFTNEKRASFHEVTVPNKLMHVYPNGNILYSSRNTLLKHACTGHQQHYSSEACPEHPFLAVSMMSPLFQFPLVPLASMSSVVFPSYVFLVGSTLNNQCHELIADSYSTKNVIFRWHDTPIITRDHLKLPQFQFDDTQNVDCTKEYKETGGSNYTCIRADFYLSRSYGYYVAQVYIPSVLIVSLSWVSFWLDIEAVPARISLGLLTVLTMTTQSANARAHLPRVSYIKAIDVWMATCLFFVFAALIEFAYVNVNSRVEKRRTNQSMIQAQGGLKLTGGGGGKGNGYNSETDDSEAKPKRLFSKTTIGRAKARRLDKLSRYIFPAVFAAFNIFYWLFYMFWEPEVERYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC46</accession>
    <name>A0ABM1AC46_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arylsulfatase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101864720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944884.1">
        <property type="nucleotide sequence ID" value="XM_013089430.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864720"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046925665" evidence="7">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012944884.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43264" checksum="543B43D197C2143F" modified="2025-10-08" version="1">MMKLSLTLLVAVWLSAVSGNDNNKNNNNNNNNNNNNRKPNIIFVLADDYGFNDIGYHGSQIATPNLDKLASDGVKLENYYVQPICTPTRSQLMTGRYQIRTGLQHDVIHAEQPNGLPLDETTMVEKMKEAGYATHLVGKWHLGYYREEYLPWNRGFDSYFGYLNGMETYYAHKQNFSDGNWYLDLRDQNGPVHSEEGHYSGHLFTEKAIDVVQAHDPRKPLFLYLAYQSVHGPLQVPEKYERPYRHIQNQHRRIYAGMVAVLDEAVGNFTQALKDKGLWEDTILVFSTDNGGQVFTGGNNFPLRGWKHTLWEGGCHGIGFVSGGRLPVSGVVNRELIHVSDWFPTLVGLAQGSLNGTKPLDGVDQWDTISRGTPSKRTVLLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACV4</accession>
    <name>A0ABM1ACV4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC106013611</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106013611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945263.1">
        <property type="nucleotide sequence ID" value="XM_013089809.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013611"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF108">
        <property type="entry name" value="CLAUDIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012945263.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25611" checksum="2FE9D6E78FA17764" modified="2025-10-08" version="1">MACGFGTLVVSMLILFAALALTIVAAITNYWYVVESRDITSEEVRRASNYHFGFWMKCYDEEPPKSIPVEDLTSTGKDCVTIFEDLMQRPGVNQTAEEKLVIDLSRSYIALAIVSGVAQLATLVSLLCGSWPGDCQNVRRQGLYVSAAFILLVAIMAGIASGICFIAAREVETEEMNFYSRLDTRFGWSFMLHWGATGLALLDGFLIMCLVKYAADDVNNTAKYYYYNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEE1</accession>
    <name>A0ABM1AEE1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101848795</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012946086.1">
        <property type="nucleotide sequence ID" value="XM_013090632.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848795"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16520">
        <property type="entry name" value="RING-HC_MIBs-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040847">
        <property type="entry name" value="SH3_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18346">
        <property type="entry name" value="SH3_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="18">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="17">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="18">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="663"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="798"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="878"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012946086.1"/>
        </source>
    </evidence>
    <sequence length="921" mass="101944" checksum="BD773351628019DA" modified="2025-10-08" version="1">MELGLRVVRGPDWKWGNQDTGEGHVGTVVEIGRPGSQTSPDKTVVVQWDSGARTNYRVGYQGAYDLRIFDNAPVGVRHQNIICDSCKTQGVQGMRWKCTKCHDFDLCTLCYMQDEHDPNHSFMRFDTASTVKGVKVPKRSQSHSQKVQAMGVFAGARVCRGPDWDWGNQDGGEGKIGTVSEIRGWDSESGRSVAHVTWASGSTNVYRMGHKGKVDLKYKHVASGGPYYKDHLQVLGDVVAAQGGVTPSVFKVGDKVRCNLDMEVLKQMQEGHGGWNPRMADYINKMGVVHRITDRGDVRVQYDGCANRWTFHSEALTKVQVFQPDDFVRISDNLQQVKDWQAGHGEWTEVMKNTLGKIGVVKTVYSDGDMRVLVCNQEWTFNPLCCSLVPHRIDDMNNTLGSGYERDPMPAFTSILEKLEELQLSHGHETGPDRLVREAAQGHVEVVRDILVKYPDKVDQQSSGKTALQVASHQGHRDIVQLLLTSQASLEVKDEDGDTALHYSAFGNQPEVMQLLLSKGAKMDSLNNGGCSTLHVAVNKQHQECVKVLLQRGCNVNIQDAYGDTALHDAIGKENQAIIELLVAYHNIDFTRRNKRGFNVLHHSALKGNVFATEKVLIKCPQIKDLKKDDGFSSLHLAALNGHKDVAASLLTHGAEIEIRNNRQQTPLLLAVSQGHTSIIELLVSQGADVNVKDEDGDTCLHLALMRQTVATEDSSPMLDAIRSQLGMSEQEEQTGAAIACYLAQQGAELRAKNHQGKSPLDIISDRRVKEVVLQFATAFASNSEKSQVKEKESPKECELCCTTTTLVTFEPCGHTIVCADCCVNMKKCIECKRLIDLKRAADGSIISSGHNPSSSLASEEEAFLKKRLQELEDTINCPICMERQKNRVFQCGHATCGTCADSLRNCPICRKVIKQKINLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEP5</accession>
    <name>A0ABM1AEP5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106013919</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>riboflavin(in) = riboflavin(out)</text>
            <dbReference type="Rhea" id="RHEA:35015"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the riboflavin transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946245.1">
        <property type="nucleotide sequence ID" value="XM_013090791.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013919"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009357">
        <property type="entry name" value="Riboflavin_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929:SF10">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06237">
        <property type="entry name" value="SLC52_ribofla_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012946245.1"/>
        </source>
    </evidence>
    <sequence length="588" mass="63759" checksum="ADA14DD831FAA055" modified="2025-10-08" version="1">MVVVAGQHNKREEHGKVGVHILVCLFGITSWSIMNGLWVELPILVSQLPEGWTLPSYLTVICQFGNLGPLVFSLLTYLFPSTQLEQPASLCVVTGLSLTALLYAFFWRETAHVAGSLYSIAVLSLTLVQAVFASTTSMCYVTFMAHLRARYMPTLFVGMGLSGLLPALVAIGQGTADVRCVLNTSLEAGSAAVTGTWPGGGDLTYGLLNVSNSNSSNNSSNNSSNNSNSSVVSMVIDESVSILPSNQTLVALNQEPAFTVRAFFLFLGGLGFVSLCALVTLIHHPYCRSERVNTEEEDNCKLMSKSTRDEETHQTLLHEAETTEQIPLPHLPSSHLPEDSRTDMEQDDVTTQQNDVRFIQPGKLAPHTDTLATPTDTLVPPTDPDNHGVKDERGGSEDGGKREDGGEEGGRGEGGERELSRGESWFLLCLLVWINILQTSYVLAVQVYSSLPYGLYIYNITTKAENIVDPIACFVSLFVTAKSPRVISGLTSLGTLFTAYVITVAAMSPRPFLLDEMAGGVLVVCAWIMCTMFMVYAKVSIAAVMRTQGRQSLLWTGASTQLGSFIGALLAYVMINHLSLFKEGPWCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF62</accession>
    <name>A0ABM1AF62_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC106014035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946494.1">
        <property type="nucleotide sequence ID" value="XM_013091040.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014035"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19338">
        <property type="entry name" value="Wnt_Wnt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009143">
        <property type="entry name" value="Wnt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF72">
        <property type="entry name" value="PROTEIN WNT-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012946494.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38767" checksum="3997FC9E607FF846" modified="2025-10-08" version="1">MQVQGIVTCLYFVLMFPADIIGLWWAVGSPLVMDSNSICKKTKRLAGRQRTICKREPEIVAEVAKGAKLALLECKFQFRNRRWNCSTARRSINRILRRNIRESAFVYASTAAGVVYTVTQACSLGTLPKCTCDHNARDVSTDGEWEWGGCGDNVDYGYRKSREFMDARKRKRRGDFTTKIQLHNNEAGRTGVKNFMRRECKCHGLSGSCTLKTCWKKMPPFREVGNRLKERFDGAIRVIISNDGKNIIPEGLTIKPPSRHDLVYSDPSPDFCKKNKKVGSLGTRGRECEPDSMGVGGCDLLCCNRGYSRTSVTMKENCKCRFLWCCEVICETCVSTKILNKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFG1</accession>
    <name>A0ABM1AFG1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101846559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="RefSeq" id="XP_012946627.1">
        <property type="nucleotide sequence ID" value="XM_013091173.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846559"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012946627.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11728" checksum="E50F886CF2E522E7" modified="2025-10-08" version="1">MGVTVETIQAGDGVNFAKAGDTVVVHYTGTLQNGQKFDSSRDRGKPFQTKIGVGQVIRGWDEGFTQLSKGQRAKLTITPDYGYGASGAAGVIPPNATLIFDVELLDIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFY9</accession>
    <name>A0ABM1AFY9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101845527</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101845527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946895.1">
        <property type="nucleotide sequence ID" value="XM_013091441.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845527"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045906713" evidence="3">
        <location>
            <begin position="20"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012946895.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="52613" checksum="8F21AE757446B27E" modified="2025-10-08" version="1">MMFLSVLLLLAVVFHLCICVTIETVKVKTSSESCSQTINMKFGIAYTPLIQASNCEKCRTAVDCPLMLPKECKLSFTIADEIEKVLSKICFQSGAFEVDDCFTTVTFQEKTPRSTNDLETIACHNDKYVYGSSRDICLEKGQSLDMVFSGSNLCSVKGYGRVELSRSLYDQDDLSDPNSCRSVRMYKNRDSGTVYSRHKETAPAVIKFCKVILSPFNRGHPQDFCYRFHYAKFLPGGAQLLIAYRTYGYKTRPTIDSEYCMSMLEETGIKVEIKTFCYYLNPDKCVASAQHEFVFTYRFKERQEPDFTPEVEEGYEDNSSKIVVIIVCVVVVFILICCCICCCYIRKNSSNSENGTAAAAEPLNVGSPDGGNSLPVFVHPSQSISTNSHGRAIYQTSDLSSPQRPTAPRWSATHGPSSPNEFSPTSPVPDRCPSAPPLEESEPFVDHRGPTVQADNLEMPPPAYDSLFPDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ80</accession>
    <name>A0ABM1VQ80_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852394</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824572.1">
        <property type="nucleotide sequence ID" value="XM_035968679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852394"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824572.1"/>
        </source>
    </evidence>
    <sequence length="888" mass="98031" checksum="99B8B09496F08791" modified="2025-10-08" version="1">MKTKTTGKHRAVSQDILSFRRHRIFRSDNGARARIRTVNFSTKAMKPGTGRVQTVELPLSPEHGTSELPVTSSLDPTNNTNRLGSLLHPEQKKVPQTSTTTNTNTSSLFNGSIKGHLTVTASRKQPAHLELFGMRMEAPTSRRRDLSSPTWTSSSFSMNEDTRKSKLSQNKVQAVEIAAVNPSAVFQSSEVTTSFVSTYSDMQSRRSSSTGSYLSSQSFHPNVSLSGMHHSFDEDSSHDLNATNVPIGKMYRDSKSIHPTQQSFRELCDLEECSSYSSLLTKDPTASPYLGTTQNRWELNVPESSIFDFPTICNTERNQQCELPMIDDCISDADQGLPRRLLFHVDEGNSGNISVSSPFREVPRPDSFCSPTSFFTLPFDTSSIHHGITQTRISNDNNMQLMTQNHNDFFDSPCQNAYDPTEGLERNFSNSVPTFSLAGRNSFPSSVVKPSSYFFSPILSEPNPTFCHANFPILSKSPEKDLCTDQARGSKLNQDKCAVSAVCLNNGHAGIRQGLQNHQDRLVPVMFGGQSPFSGDVPPTQDAPSLVTSCGCLGSTDQCGQTDPPRRRPDARQTMTREQSMTCLTSSWCSMPPCPSLPRQTTRCSQWDTPAPQTSAGATHTSEEWPVPNQENSERGPKVKDQTTVAQTADRDRLSPNLPATTTTTYHTWVAPSSGCKKTPTPTVSLFPPRCSQTPVGREPEQTEPVLPHKNASFQDKNYFSGNNDSSLSNNDKESLPKDSMEGQDRTILHDKKKTDEAKQSQLHPAINERKDEDQGAQSLGNCVFQSCGDAFVSPRNVRGTTFTAKIDQKENRDPMYKAEVSKYGRVSCSTQTTPKLLVDASCGTLLPFKKRAIMKHASHNTDMDEAFVCGAGGKNYSLRSRSNKRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRF1</accession>
    <name>A0ABM1VRF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101847814</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824993.1">
        <property type="nucleotide sequence ID" value="XM_035969100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847814"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-2/delta subunit conserved region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824993.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40984" checksum="78DDA48A7397042B" modified="2025-10-08" version="1">MTLSAFNEKFSHYTSTSNYCPGGTCPYTCNDTENFHCYLVDNNGYILASNNPDGNGTGLFLGQQDGRLMRALLEDKIFKMYQLTDYQSICQTMLTPDQESSSSFPMNPLRLITRLFFWLISEVIIFLSEWNLFSSLSPYSVFGMPEPNGDDFPTGKDGEECGLWIPERLARYIYCGFVVYEDTGFRPVMSIYTTKRSCEQTVSRFVLDKAALLRRPARHKLPDCATQCATPHETVYEARWLNETNLVFLVSDASCYCNSTHNDTEEMMDLESPYTFKVTPKERTYKDDLQCQILLNYSNELKRVDNTRTQSTLCLDSSNETDKPCGQSNNAFSQRPVNERVASVLLTVLTILTTHLVSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VS37</accession>
    <name>A0ABM1VS37_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="9">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101853746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="9"/>
    <dbReference type="RefSeq" id="XP_035825229.1">
        <property type="nucleotide sequence ID" value="XM_035969336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853746"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="70"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035825229.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="49364" checksum="EC455DCFF4749F07" modified="2025-10-08" version="1">MAEANGDKTTIVEKDPDNAVSGKRSSVSAQNSRNIEDYESISGPISYNSFSHDPQFGAIVREGEVAIDAGIEPKLSAKGTSGCYFVKNKDQKIIGVFKPKDEEPYGQLNPKWTKWMHKLCCPCCFGRSCLVPNQGYLSEAGASLVDEKLGLNVVPKTKVVRLASETFNYSAIDRAKARTKRNIYNRVPIVGKHFNRIGLPPKIGSFQLFVNSYKDADYWLRRFDNEALPESTAKHFQHLFERVVVLDYIIRNTDRGNDNWLIRYEPARANIADSSREEAEDSEWSMVSNPEISVAAIDNGLAFPFKHPDEWRAYPYHWAWLPQAKVPFSSEIQELLIPSLNDMNFVQDLCDDLYDLFKNDKGFDRHTYEKQMSVMRGQILNLHQALKDGKSPVQLVQMPVVTVERNKSVVGRTRADSEIFTQSFSHRAPFFSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSI8</accession>
    <name>A0ABM1VSI8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tuberin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825380.1">
        <property type="nucleotide sequence ID" value="XM_035969487.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847034"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003913">
        <property type="entry name" value="Tuberin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01431">
        <property type="entry name" value="TUBERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1631"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1338"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1533"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1877"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1277"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1393"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1443"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1540"/>
            <end position="1549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035825380.1"/>
        </source>
    </evidence>
    <sequence length="1911" mass="214628" checksum="E37C8AF2D4008BAB" modified="2025-10-08" version="1">MSGAGKQSQKNEENFSKVKEKMQRLFGFGKPSTPPAIPKATTREVVFTTEILKEIGPESPANNRLRRIRELCEVVKLTRLEDNAVEALWGQISDLLQPQVVEENRHLALRFLHCLVEGQLPYLTIVRGHFFRVIQGLTDPADIQYRLQLFDTLSECGKNLLYFEDETGVFLQLWMPEVMSAGYVASFLPIILNVIKYNAAYVDEDVMAGLVQQTCMIPNRSRCDDELKKCLQVLDAVICYSYLPSNCLHHFVAALCHTVDKALFSEKSWELMRKLLGTYLGHSAIFTMCCMLQDKRKPVDILLLRGAIFFTGMALWGSRRVSTLKQSHSSVLPSFYEALSHENNIVAYEVVLNLQRLVSKYGKDLQHVTWEIVLDILQRLLTQIDKCGFERKVMTETHQVITSIENLYRNRQFFGPTARFFRLVEMCASKRPSSSVCALMDYQTQFIHPGQENWIEALNQLMERYLKGQTRTEVRKKSLEVLSLVLSINTHVYERELIEHIVLPHFSHCDTDPDPEVRCQSVDLLLGLCEDCHSNEFFELSIIVEKIVKKPLVSSFADSERKEEGTLGPEEASLIDVRMAILKIIEVFKVKLYTAPASHCQRLYELLISHLEMQYSHLYLGRLACQLRKAIFNLLLLLRADSRSRVGLADRKPGERHVYSPYVMCRPSEDMESLLLKSPSVPGLSPSQIYSVIEYEHTFKLFLRCLETERDWTVLHTVLEKLTLVLENKTMVLSASSDNELLDALCGKLCAMVKDRTVEQSKKLINRPPNFTRSDFHACVFPVLASMVTYHAYLDKTRQRELVNCLEFGLVSKCAKICVTTLRICSLEMKELMMRMLPAVLLSLSKISATISMAIPVLAFLSSIVRIPKLYANFVEDQYMSVFAIALPYTNPFKFSHYTVSLAHHVIGIWFIRCRLPFRQGFVKYIQRGLKYNVLQLFEENSIRHLSAHNQDSSDRGRTSSLNEGHRIRRRNISGIEGVRNDGRIPMDEKMSQFHKELTETCVDMMARYAYGNFTALPKRSPMAQFLLKDGQRGMWVVGNKIITITTSGGGAKTNNSGLCDKCLSSYLNTQDPRKEVKRSAPIAMGSSAGESRRRHKSMAALGRSQTQVDSLGISLECEEPRRSRDDMSLPQEASTDIFGRDDAAVQTGSSLTTSANSDAMDAGFSGPKGRMSEQRTFSLSQCSCWCTSWAEVNIRGASGVVCWMMRIENESSSPSFSSDPSAPDITQLLAPVRCKTPDSDSLGKIDSGSLCEEEYETLHSQHFSEAERRLFHEEPLSQTDTPTQDVSDSIQTDSDLQFQSPSNLRRISSSPSVLSGSQDTCQSPRELLRELVECTERERQAETATRVESLGSRARPEAQDFSHTDTTFPHSGIRERGSSGATADPDVLGTRNDPQQGNSSDGNAQSSSVICKSRRSGEKSSDLARQLSLEEESPTDVARLTKMTSQKSAESSDSVFHVNPALTGTSFPAGRVGHLASTSSDGKAMVHRSTSTGKSFEPKKSVQRTMSEDLAGKKRPEALNLLSSHTKVFDRAAVEDSPNESSTPSSLQDEVPELRQLKRRGHTISVMSPAGQVRHSDDYDGRLQSGGPKDAKGGLSPSYVFLQLYQCHPMVQNQEVPLRVPDNDKFRRTIDMLDHIYPYETHKIGVLYMGKGQPSDERTLLGNEFGSPRYTEFLQGLGQMISIEEAERDKIYLGGLNPSDGKFTVTWQDESLRVIFHIATLMPTMPGDTRFNNKKSHIGNDFVTIVYNDSSEDYKSGTISGQFNFVSIVIRPLDYESNAVSLITKEAELRDQITPGSSGEMKDIADILGHTHTKIISDANLPLLVRQIAVHCNLASMVLQRQQSTLGTPEVFASNWLERLRQIKLLKRRIIEYQPEEAGGEPTSPSHVWPPPGASGDTGSGGCEDFTDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTS8</accession>
    <name>A0ABM1VTS8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pancreatic triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825820.1">
        <property type="nucleotide sequence ID" value="XM_035969927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848521"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF178">
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        <source>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035825820.1"/>
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    <sequence length="363" mass="39548" checksum="7D810F0615858469" modified="2025-10-08" version="1">MSRSSVVSVCFFLAIGIHLSYGWLFSDWLSRCYDSPPVGCFPTSHPYNNSGSLGPQSPSRQQIRFHLRQRGQRRQSFGYNNARTVLQRKYNPSHKTVVIVHGYLESARSAWVVDMAHAILNREEANVIVVDWRKGARSLVYPLSVANTRVVGAVLALVLQELVSLGGDLSTFHIIGFSLGAHVAGYAGERLPGLGRITGLDPAAPGFRRTPPPVRLDPSDATLVDVYHTDCSPVMGAGLEEPLGTVDFYLNRGMEQPGCGSTLLGRFAAAIQQSRDFSAFSREFACSHSRAYLFYISTISNNVCEFPVQTCSTVASVLSRGCQACQCPNCPTPGYGYEASGDRTLASRLFNVETTSSAPYCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABM1VTV0_APLCA</name>
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        <submittedName>
            <fullName evidence="9">MAM and LDL-receptor class A domain-containing protein 2-like</fullName>
        </submittedName>
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        <name evidence="9" type="primary">LOC101860497</name>
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    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="nucleotide sequence ID" value="XM_035969949.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="LDL_receptor-like_sf"/>
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        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
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        </location>
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    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="8912"/>
            <end position="8927"/>
        </location>
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    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="9118"/>
            <end position="9130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="9125"/>
            <end position="9143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="9509"/>
            <end position="9524"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="9698"/>
            <end position="9716"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="9932"/>
            <end position="9947"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="10140"/>
            <end position="10155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="10337"/>
            <end position="10349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="10356"/>
            <end position="10371"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="10537"/>
            <end position="10549"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="10544"/>
            <end position="10562"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="10785"/>
            <end position="10800"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="10970"/>
            <end position="10982"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="10977"/>
            <end position="10995"/>
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    </feature>
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        <location>
            <begin position="11204"/>
            <end position="11219"/>
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    </feature>
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        <location>
            <begin position="11221"/>
            <end position="11231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="11243"/>
            <end position="11252"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
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    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
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    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825842.1"/>
        </source>
    </evidence>
    <sequence length="11382" mass="1247629" checksum="071E5D581A00C0F1" modified="2025-10-08" version="1">[encoded data, 11382 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVD7</accession>
    <name>A0ABM1VVD7_APLCA</name>
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        <submittedName>
            <fullName evidence="10">cAMP-dependent protein kinase type II regulatory subunit-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101851538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826379.1">
        <property type="nucleotide sequence ID" value="XM_035970486.1"/>
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    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DD_RII_PKA"/>
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        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
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    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
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        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
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        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
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        <property type="entry name" value="cNMP-bd_CS"/>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
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        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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            <begin position="121"/>
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            <begin position="61"/>
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        </source>
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        </source>
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        <source>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS50042"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035826379.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41790" checksum="0E80713CA69BF0FF" modified="2025-10-08" version="1">MNLEIPDGLGDLLRDFTVAVLKERPGDLYDFAVDYFTKTRDARKPKDVPMYIIVEDDDEAGEPDKAAFRPKSTSGRYARRQSVSAERYNPEEDDDDDDKIVYPKTDEQRERLTKTVSGILLFRSLEPEQTSEVIDAMFEKKVQPGETVITQGDDGDNFYVIDNGVYDVLVDVKGEEKKVHQFDNRGSFGELALMYNMPRSATVRSASDGTLWAMDRNSFRRIVLKSAFKKRKKYEDLLESVTILQNLDRYERMTLADALVPRVYQDGEPIIRQGDDADGVYFVEDGHIRITMSSSDGSEQDIGMRTNSTYFGELALIENKPRTANVYAVGRVKVAFLDRDCFERLLGPCVEIMKRNSQLYTMFVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXS9</accession>
    <name>A0ABM1VXS9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF21 domain-containing protein At1g47330-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827222.1">
        <property type="nucleotide sequence ID" value="XM_035971329.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="ACDP"/>
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    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827222.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13794" checksum="75ECC70BA63CD7C5" modified="2025-10-08" version="1">MSDTVVGIITLEDVIEELLQEEIEDETDIVQEISQKLQFSMAKRQKSLQNLMHRCLSMPQQSCGSGVLVQRGKQGNSPDIERQLSTSLQEEHLASMGQGRRQEGDGDNDAAPPHRTESRVRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXX3</accession>
    <name>A0ABM1VXX3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Globin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Myoglobin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101849391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827266.1">
        <property type="nucleotide sequence ID" value="XM_035971373.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849391"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22307">
        <property type="entry name" value="Adgb_C_mid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053033">
        <property type="entry name" value="Androglobin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054093">
        <property type="entry name" value="Androglobin_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054094">
        <property type="entry name" value="Androglobin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054095">
        <property type="entry name" value="Androglobin_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057249">
        <property type="entry name" value="Globin_CP_ADGB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46298">
        <property type="entry name" value="ANDROGLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46298:SF1">
        <property type="entry name" value="ANDROGLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22068">
        <property type="entry name" value="Androglobin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22069">
        <property type="entry name" value="Androglobin_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22070">
        <property type="entry name" value="Androglobin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52042">
        <property type="entry name" value="GLOBIN_CP_ADGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="5">
        <location>
            <begin position="234"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="545"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="865"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="955"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1231"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1569"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1690"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1826"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2008"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="628"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1581"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1613"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1626"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1640"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1696"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1710"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1737"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1835"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="2016"/>
            <end position="2029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827266.1"/>
        </source>
    </evidence>
    <sequence length="2029" mass="224988" checksum="FEC3C47A178FBECF" modified="2025-10-08" version="1">MSLLRAASRFRKSGGRKSVESTDGGTEPGTEETARSPSSARGSFSNALAKVSQLKKLMDAASVAASAGGQDSKRPKFTIWPEWNDADVNAEKWGADAAKKEDKKGKSPTVSQHYFEDPDGKIEMPPSLRVDSWKRPADFLMDKVPVIVDTDHVSSGFDLIANNEHLHESEFLRYCISQVMALWDMCSVPVPPDVNLEATAPGDDPSHSWRPWEHIYALCKAGKGPHLPLYNSHGKYVVRLYWMGCWRKITIDDTVPFDDQGRMLLPSTTLTHELWPMLLTKALIKVASLDYSGGNPSQEFGDMTVLQCLTGWIPEAIPLLPSHMAEVWQLMKKALPEWTLPEQEWEKPPETTDVTSKESVPSEGAPKEEKLEKEGTQKDMKDGKAEKGKDGKEKGKDGKEKEKGKDDKKDKKDKDKEKDKDKGKEKSSLDDIVLPEKPELVMFATYSSTPKFPVKVSVLGEMADASEKLRQNGLSHQYPHPVCLTQTRSCPLEPPPPPVVIPSWKLIRPRKRKSPPHDEPVADPEPPKEIQCLEITSAFVNYKVSPVPIPTDTHRPKSSLERGGARSRADTEGAIEEMDENAPTPRTLTPEPEPAPPVEEPKEEEEPPKEKPGTPKRKASGKAGRGSASKERSQTKRPESRQSNKTDDGKPDKVKESQKAEVPAPGGPSLGGNAAGGLAPPANVVLGPDGEPLPAEEEEEPPKEKPGTPKRKASGKASRGSASKERSQTKRPESRQSNKTDDGKPDKVKESQKAEVPAPGGPSLGGNAAGGLAPPANVVLGPDGEPLPAEEVVPEPPPDNTPKPKKAWMDFDIFCKCFRTLYIFHKSNTYLCNQYYSDLKSRTLYIFHKSNTYLCNQYYSDLKSVTPSSTTAPSKTEKRPPQATSTRGSLMARASLLLESHEEMEELEEAPNDGSPFYLFVDNLAQTEIVVSYSVLSRWFDPPLPLVEEKKALSQIKQGKEKDLDKEPTNASISLDSVVGEQKPPPPVQPGTLVAEPYSWKSLVTGQPILRLRTTGTKSAVLTLPPGRHVLRFMMSSPLGHHVHMCSTVNFVFGDEETVMPQLTNESCRFRDNAVQVIMNLGKCILAFKDPTMLTSAWAELVASHCPYLEDKQMSKTHHFQVFNEALYQMLKKTVKDIMSPDIAFAWRAFTFDATTSNILAIPVGSRPATQGSNAPGGYSPPFPGEGLCVFNEALYQMLKKTVKDIMSPDIAFAWRAFTFDATTSNILAIPVGSRPGSQVTSEEKLAETKATGSASVRGSAKPSSKKHSTQADAGEAEKPENPWANREASVEEQIQTVKIQKVWRGYYVRKMKAARTPGTEENLKVAENLTKSWSQIESTAEENGLVLLREMFKRDPDIMSLYPFYQDEWNKISYSDYKGVYQEQPSLTWFIVFRDIFFVQEEMLLVPRLYVPIGTCMLRVIDNDTGQEVPRVFQKVAPYVYKKNKKGYSFVAEARTVEQPITSGNWRMRLIGSLNALPVPQSGEVCCNFVTKEIRDYYVPNVKNTIFRQAVKVTEDHFSSLQVNTSKPDVYIKLSVLDNEEEVISAVGKGHVVIPAFTFLKDITQEDIENRRSSSRALPEEEEGGEDEPEGQKNQPTEDAAVRGSIAAPATKAEKSTSKLKRTESAVSTEQQPPSRSSMRSDAELAERLEDSRPHKYIIQATVLQNSWPLSESSWRFVQMLKEMEKNELKVFGDSDSDSDSSESFDEEVTAKERPPSPPKVEKTPAAAGGKAKPKAGKDKGGKDKGQEGKGSRPSSQQFDITKPNWTLRVVSDAVTAEEIEVKKDTERADEIRAMKKAWEDAEPGRAAKALQSRLKYLNSHTVKLGASEDDQSAETAASSLTTGTGPPTAAESGATVTEQESLPGPQTPVSLGEHFESETTLTLEPPPPPAAKEMLEPLDVTPFVRKTLAEPRYLGEEELHQLLEKRQKDVAEYKAFREQVERWRDADRQMRNKTKLQQLEQCQALQATLDAARERINIPRESIRQRFLDAEQKRIEELANQEAAMKAELEAKSPKGRKKSPSGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZ29</accession>
    <name>A0ABM1VZ29_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Schwannomin-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827672.1">
        <property type="nucleotide sequence ID" value="XM_035971779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858126"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039045">
        <property type="entry name" value="SCHIP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015649">
        <property type="entry name" value="SCHIP_1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13103:SF2">
        <property type="entry name" value="IQCJ-SCHIP1 READTHROUGH TRANSCRIPT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13103">
        <property type="entry name" value="SCHWANNOMIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10148">
        <property type="entry name" value="SCHIP-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Schwannomin interacting protein 1 C-terminal" evidence="3">
        <location>
            <begin position="385"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827672.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="70211" checksum="2789181E62096194" modified="2025-10-08" version="1">MTLLTPEENQGGGDDSSATAPADSEDELDGAEFSSSETTALLPPGREDSSNSNSNSDNSTGANDDGADINKTSTTTSLDPQTVLSSLERTRDKKSPSRFSVDVECESVVSDYSELGGPLKDIERDVHYLDRDTLRSEEGGDSWLELSRQEGEFESEVERREGESQADFEKRIRKINLLSLAQEFAELKKVDAQACAFNFHRNQSVKNLRQSLSPAGSRGQSIERSRRTNSKSPLRASSLAGGGNMPGIMATSGGHDLSQKDGKDGTSSGAENMTTSLPKNYEKSSVAAANQRTEDPPANEARRGDSNLDLPANMRPNRFMMGSPRLERDGSRPANAGSQGNSSDAEGDFDVYNIESTLPHVNWATLEKQLEIAAKEGQNRLESCKNEREEIRRRLAMSTEDETTADEPDPSETLSPRKQRLQDRLQATPSGMQICFMNDDVLDDDEDDNLITARLDDPDNESSSCPESSSEDKSGSLTEASQVPPLPNHPCFPGEVAQFTARQTQLQSEATLALAQASTMARMQLEVEKQSKKKSPIADMVGIPTLGGGRRLRLTGGKLQEMNLAQLQVLVNDLHSQIELLNEDLVHLLIERDDLHMEQDSMLVDIEDLTSHCHDPKTTNNNKNLLNNNRPTSRRDRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZV1</accession>
    <name>A0ABM1VZV1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101859196</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101859196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827944.1">
        <property type="nucleotide sequence ID" value="XM_035972051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859196"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039631">
        <property type="entry name" value="LRRC42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31994">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31994:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827944.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="51038" checksum="56683DCACFF27730" modified="2025-10-08" version="1">MTSELKSLFHICLDYISKSLNHVESLHGFPDVVGKQIFESATQRGHFSNLRSKESSLKDLQLFFTAYGTSGILERLDLRNCQLFLNDTVDDHWWLYHGLTRLNLTACGLGDSHDLLPQLTTMNRLKTLVLRNNGLSDEGIRKMTTRMRMYGLSSVELTHLDLSENIKITSRSLKFLVSFRKLQVLNATNTAIRVTEPHSLWKRHDDTCPDVIDCWEVGTSGWAAQVVDSWVQEYENPVTGVTSGRSGASLCLRQTSGSDEITTSFYPKKRLPVNVTSSLDSPARGVSGCLFLMSPFVQCTCRRQQGTQRSSVGDSRGQRFSQDSLAGLGLYVDEDSDFEFSIAPHKKRKRKASSEQGLPSSPCGSCPSGSKCSKACANKLRGVPKRQMGSFHEIGLCDFENVNNSGVCSTERNTESERENTAQDDSAWLLSQYTKGSPKQRTSRNAKLSLLNKMDGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W5A1</accession>
    <name>A0ABM1W5A1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 628-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC118477209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <sequence length="1093" mass="118842" checksum="940895C3BDD82607" modified="2025-10-08" version="1">MESERKEEEGWVGEGQVSPLDTALSTFGELDCGESVDAVVSHFPNYGPVEGLSTDAGGRERLLDDGDIVEGMGGQELNHDNFEEVAGLGVNQGDLKEVGGVEVNQDDLEEVGGMIVTGDVAVNGISEVLAKCRPDLTDEGGGRFVGKKADRSDPVGSGRRRGHKDSNSCPQHRVGAGGKRVLNSSAKGSGDESSEDIDSGSCGSSTVTSSRSAETRVTTRTQLRVSRSVALTRGKRTGEVEDNVGVQTGPGIVSKGCKKPDVRRGRRGEAARRGKIGEVVKEGEKVTRRGTRGEVVKKENERLPIKRERGGRGKGAVKLDRIGNNRALSETVEELSVVKIEGEESDDGADENWELEGNGREETGDIPDAKPRGVKRARKLVEAKCVRCEHCGEEFPSQKAYFDHRKAEESWQTCTVCGKVEPFMAHLIVHMQKHNPVKVDHLSDDGEEEKEKTSNVGGGGMLAHTGPSGDSCVPTERVDEASEGVGGVMETQNSVATRKMVGLPQSESADHKTTISVKGERDGKNDGGHKKAEKRKGKESKKKKKERMKCEMCGEVVSSMDSLKIHTMLHTGELAYRCCVCPEKFPCLSARQHHMNSHLTALRFRCTSCDLRFLTRADLAKHQLSHQIQCGVCGEVFPNRTSRNCHYRTAHPDRILRCDQCTAQFGSAEELKRHLAYHRKDKREQCPTCGLVVCKLKEHMLVHAAAKGEQQERLFACDQCPQRYLRRTNLDRHMLTHSGERPYACDRCPKRFRSNGMLRRHLLTHTREKPFQCEVCGKRCAIRSNLSIHMRVHASHRRYACPHCSHTFNHKNSLQGHIKAKHSQPEEEEDGEEGRVVAMSDSFSSSHANSHVLMADSLTSSGLVLTQDHPPASHHQAGGPPLPPPQPPASHHSGHNPPLPPQQQQHPVYSTLQPTPPLHLSSSMTFAPELRKALDTPLTSTYALSLSSRLAQDVMTPDQRQSDIGLAMPSSFQSLTSLQLSDKVEMPGVSGGYVAGLMDKPGGGAGRGGDPSDMSGGVQISLAPGQASLAQGLTPDQVSLSSSLAPGQVGLQSSLMPGQVSLASGLTPGMLIDTDKIFLTKFDMNQHSMDPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M4VNF2</accession>
    <name>M4VNF2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Acetylcholine receptor subunit alpha-type acr-16-like precursor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="18">Nicotinic acetylcholine receptor subunit type D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101851082</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="J. Neurophysiol." volume="112" first="446" last="462">
            <title>A potentially novel nicotinic receptor in Aplysia neuroendocrine cells.</title>
            <authorList>
                <person name="White S.H."/>
                <person name="Carter C.J."/>
                <person name="Magoski N.S."/>
            </authorList>
            <dbReference type="PubMed" id="24740855"/>
            <dbReference type="DOI" id="10.1152/jn.00796.2013"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AGI03860.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001280843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M4VNF2"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
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        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
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        <property type="entry name" value="Neuro_actylchol_rec"/>
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        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
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        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
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        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
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        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
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        <property type="entry name" value="NRIONCHANNEL"/>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15 20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022260976" evidence="15 20">
        <location>
            <begin position="23"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="40"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="253"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000687"/>
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            <dbReference type="Pfam" id="PF02931"/>
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            <dbReference type="Pfam" id="PF02932"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGI03860.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="NP_001267772.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="59189" checksum="F3645D6F99E909DA" modified="2013-05-29" version="1">MNILLRVFQFLISLSLQVPLRAQSGNYFDDMDYTRNLTDEQRLFRKLLLGYDKNTRPVFNASDPVTIFLGITLTQIFDLDEKNQVLTTNVWLDQEWHDQKLIWKPEDFNGLNKIRIPCRHIWKPDIVLYNSVEDYTDGYMQSLAMVSHDGTVFWPPIVKFQSTCQIDITYFPFDDQICNMKLGSWAYDGFQVDVNNRSVPVDLSNYVSNGEWHLVSVTAKRNVVYYPCCPEPFPDVIFTIHLQRRTLYYTYNVIIPCVMLSSLTLLVFWMSPDSGEKVTLGLTVLLAFSVFMLLIAENMPATSNFVPLIGMYLTSVMGITSMSVMLAVLVSNISYKGQHQIPLPRLMRYFIVGLARIMCTKLYYISPPNKTGGRVLSPARNRRNFYRVGNGTHVSNDSGCALVEYELGDTLGVNLENLRLPSSVRHQQAPASVRSRSGERIKEDDIDLILSLLKKLLVRESEREEEDDLNKQWEEAARVIDRFLFYIFFLLTILATIVTLVIMPLTKPEKPTVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q6JVM8</accession>
    <name>Q6JVM8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U4/U6.U5 tri-snRNP-associated protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100533441</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2006" name="Cell" volume="127" first="1453" last="1467">
            <title>Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Edwards J.R."/>
                <person name="Puthanveettil S.V."/>
                <person name="Kohn A.B."/>
                <person name="Ha T."/>
                <person name="Heyland A."/>
                <person name="Knudsen B."/>
                <person name="Sahni A."/>
                <person name="Yu F."/>
                <person name="Liu L."/>
                <person name="Jezzini S."/>
                <person name="Lovell P."/>
                <person name="Iannucculli W."/>
                <person name="Chen M."/>
                <person name="Nguyen T."/>
                <person name="Sheng H."/>
                <person name="Shaw R."/>
                <person name="Kalachikov S."/>
                <person name="Panchin Y.V."/>
                <person name="Farmerie W."/>
                <person name="Russo J.J."/>
                <person name="Ju J."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="17190607"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.09.052"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY298750">
        <property type="protein sequence ID" value="AAQ67660.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191647.1">
        <property type="nucleotide sequence ID" value="NM_001204718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6JVM8"/>
    <dbReference type="GeneID" id="100533441"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="11">
        <location>
            <begin position="96"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAQ67660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="NP_001191647.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21405" checksum="B7241F02087A1737" modified="2004-07-05" version="1">MARSRSRSPTTSKRDRRRSRSRSRERRHRKKRSRSRSPRRRPSPQRHRSPSNSPPRRRSPSPRKRSQERDLDKPDKQNHVDGRAEIDESKLEGLDDEQVDMMKLMGFVTFDTTKGKKVDGNDVSAVNLQRKRRYRQYMNRRGGFNRPLDFACLQCTSSSLAHATLVHNPFNYSPIPPHPHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA41</accession>
    <name>A0ABM0JA41_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-related protein Ral-A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005088932.1">
        <property type="nucleotide sequence ID" value="XM_005088875.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848702"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04139">
        <property type="entry name" value="RalA_RalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005088932.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24664" checksum="2F0B1324B781C0CC" modified="2025-10-08" version="1">MSSSTPSCFLLNTAMSKAKTQQPAVIHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSIKEQESFQATQDFREQILRVKNDENIPFLLVGNMVDLAEQRQVSVDEATKRAQEWKVSYVETSAKTRANVDKVFYDLMREIRSRKMEASRQNNGKQKKKKDSRKKKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCN0</accession>
    <name>A0ABM0JCN0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cystatin-A1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090623.1">
        <property type="nucleotide sequence ID" value="XM_005090566.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847239"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001713">
        <property type="entry name" value="Prot_inh_stefin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414">
        <property type="entry name" value="CYSTATIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414:SF20">
        <property type="entry name" value="CYSTATIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00295">
        <property type="entry name" value="STEFINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cystatin" evidence="5">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005090623.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11493" checksum="26758FB4A6CD3340" modified="2025-10-08" version="1">MASMPGGLVEDKEADQSVQTLIEQVREALETKAGKTFSQYKAVTYRTQVVAGTNYFVKVQVDADEYVHLRVFKPLPNENRLPELSAYQLCKTKDDELQFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD16</accession>
    <name>A0ABM0JD16_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864584</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090893.2">
        <property type="nucleotide sequence ID" value="XM_005090836.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864584"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045905137" evidence="1">
        <location>
            <begin position="31"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090893.2"/>
        </source>
    </evidence>
    <sequence length="306" mass="34431" checksum="B86F63615237881A" modified="2025-10-08" version="1">MGGGILGVPSSLRPEFLVVVFVLIVCKVGAQNENEGGNFTEADYYSMVPYYDSEMMSSHQNYSSAPFGYRPGSATRSNSCQHVRAVPSHLRSRQHMKPHGLSSFYQKYTEAYGIPVLSSRYVSDPALRRACYTLRFLLASHSAVRQSFYRMSGRVAVIGVNEGTTSIPEHSHLPPWWNQRARGLGATPSAPVSTGGEENVLCLRTDRYNQDIYLHESAHGVHLLGAAYGIPGWDRRLRSLYNQARSRGLWANTYSMSTPEEYFVSSCMCQRYFYFYLSQLTSKTVNWTSQNGEKMTTKGEMRSDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDP2</accession>
    <name>A0ABM0JDP2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101851998</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091286.2">
        <property type="nucleotide sequence ID" value="XM_005091229.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851998"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046373938" evidence="2">
        <location>
            <begin position="23"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091286.2"/>
        </source>
    </evidence>
    <sequence length="363" mass="40789" checksum="2CDA87FE9C48C4E5" modified="2025-10-08" version="1">MARTFSLLVAPLLVVFLGYCHADPEYCDRGFLISSKFHTCWETATAKRPFSQLHKIHAVYTPQLLELYASHMCSVVKPLALDCLKNEVSSCSNMDKLLATADSSGGACTKNHLNPLFKQHIIDHLKPIRGDSPCFDVADQAYKCYEMAGEKILKSGVSHINIDFFYKVADKFFGYIWDCHVDLFKGMSDVCENWQIPMLFSLQQNAMPSLFGMKLDNYQISKLELSRNKSVLPVTTPAPVVDETCKNARVTSYLLMRVVKDKREAQPGDILVQLDAGGDLQSELTVDGGPDMNDEVYSFVADIVNSEGGIDMKALRKKLKEDRKKQREVNDFLKNIKKKESKNKKKAAKKPKAKGTQNDGMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEN6</accession>
    <name>A0ABM0JEN6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ataxin-7-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092007.2">
        <property type="nucleotide sequence ID" value="XM_005091950.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855624"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052237">
        <property type="entry name" value="Ataxin-7-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15117">
        <property type="entry name" value="ATAXIN 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15117:SF24">
        <property type="entry name" value="SCA7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="410"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005092007.2"/>
        </source>
    </evidence>
    <sequence length="1297" mass="134079" checksum="99297EBE156FD110" modified="2025-10-08" version="1">MNANENSENLKYDGTEGLVRDRNIAKATSCSASSVSTESNKKIKMATQDSSPSLIIGQQWSAWADLLSTINEIDEEEKGKDGTDKNSSDSMKLGLQDMGLFGFCPSREEFSLVECEKCKLLVKPQALKQHIESRHGPTNLSSLGNVPASALNSELGKKLLMPLPSKSSPPPSSTTSSSSSSSAGRQSSGTFRPASSGRPPTKDSLKQVPAAARINPAPRLGVSMKINRVKSVKSGHRISTATTTASSSSFSNPVVKVEKLDKLLDATSSSLSSSTAASEQLDSSPPDLSNSIIKTEPSPSSTSSSSSKISTLVNGTFKPAVSLTTPSLESSTTSSPSMVSTATLVAVTKTSADTPISTRSVTTFVTSTTRTKPLVIAPVMTVGSAVSMTARPITLKGSKISKEQRERKCLPCKDREYDANKHCGVKIHETGKPCTRSLTCKTHALSLRRAVPGRSKAFDELLKEHKAAKDALIKAKGVSQSAPSVASVGNRVLVSPASISSTMNALKQQQQHNSPQMVSLSGQRDGKASLSPNTGSTSPRILVPSCGVPTTTTFVKPRTQSNVFQRFTAHASLPSPITVKEETLTRQDSSSRLSLSSSSSELQRSDSQDSRQDQSFLSYHPKPMAVCQFGGRMNDRGCFLFSRKTDYVRAAFLSALERHLNPPPHKKLCVESNLPKESQMFGNSQDPYEFNMIDNSGNGGLNSNPASANLVSISSKPTIKPKSKLPSSPVAASSNSMTLSAISLSSPTPAPSLTLQSSSFSSLSAPAISVASATPGLALNWSVKPRESTAASRSPSASPAPALSSAASATNPGKRKRSGSSGAGGNNLIAVAGGNGTLSAVSVSTASASLASAITQQQTGLTGIISSGALNSSQTGNLIAIPSVNLTNAANLGQISAATLGTAKLNPGAAGAATSVHKNNNVFKDFSLVLTGIDSLNGQVVNISSAQLAELAASQGQTLLLNNFTPGSSSSTNSSAAAAAAAQNVNAPTIAMTGSTSATVRPAKRSRTSSSKSSHQSLSNSASKLSANALEGFKLIPSNNVISSGTLPPNAVLLDSLQGAVLTSVALAGGGANPTLVAITSSTANTNSVTVGGNPTQVLCADSSSGQILTPSSLVNGTGQSSYEKSGSSGRHHASSSSKSHHHHHQHNKAQQQQQQQQQGMALGSVLQAASSSLAVPLATGSTAQLCSNQAIFKPGSTFNLAKNVGKLTVQPVSLTFPLVNQQGLAALTSGKPTQLQQQQQQQQQQAQTQQPHTLLVATSGVGASDDQTKTVRVAAGKTELHLQPQISNSSSGNLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEY3</accession>
    <name>A0ABM0JEY3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain-containing protein KCTD7 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092170.1">
        <property type="nucleotide sequence ID" value="XM_005092113.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854848"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057890">
        <property type="entry name" value="KCTD7/14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25611">
        <property type="entry name" value="KCTD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092170.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28715" checksum="704C3A77E65CF53F" modified="2025-10-08" version="1">MDGDAKVHNFPPVLELNVGGVYYTTSLSTLVKSQDHMLSAMFSGRHLVAKDKDGRYFIDADGTLFSHILRYLRSGDLPCSSMAPQVYKEAKYFGLEELQQHIEQMPVMMGKQARLQFQSRLAGFDEAIEQILATANKKQCIVSDEIVSFAVIAIHKDSQLVMNPAFDNDHRCFVNYPQDLNSADVVIGPWESDIEDVTDRVYLRAIARELESRGFTITFSKQGSCSYGIRNPDRIDCKKTVFKFIFHWHKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHB9</accession>
    <name>A0ABM0JHB9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleolin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093666.2">
        <property type="nucleotide sequence ID" value="XM_005093609.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858331"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052466">
        <property type="entry name" value="DNA_MethProtect_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14709">
        <property type="entry name" value="GLUTAMINE AND SERINE-RICH PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14709:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="382"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005093666.2"/>
        </source>
    </evidence>
    <sequence length="586" mass="65407" checksum="1E04AA1BCFF9759E" modified="2025-10-08" version="1">MAGIAAPIHQETITAQVSTTGAPGHPISQSTEMSETTSDNAKGDAEVKIEVKTEDGPNFEETRDELNTDTPVKSEEDGGKRRTRKVKMTSLAELSDTDESDENIHQPPPRKRGRPPGVRGRGAKAKKKDVTSDLVDSTRTPRIVLKNIASDVGTVSPPKRGRGRGRGRGTPGRGTGRGRGRGRGRGSAAKAKVSEDEDDDENDSGEDNDDDDDDDTANPTEDSEEEQWFKQKKKPRQSSGRGRGRGRGRGRGAKRASLENKEDGMDDDEMEMSATNDASVNDLSGPIRTGQFMIEKADLRHLENYPIWRMEGPNMLRKFEMVVLDGQVLHKSQYAYSSWAQSMSDLYDRIQVQQLSSADGEITVKVKKDYQPTPPSLENLQSKFAGEELLDSYQLFVKAMFQQALDSKFLTNIRDHGDSTYLDAIARLDNLVTQAVRRIESLVKMKEEFMTRVKNCPNMKGIKRQNWSQTDQATVDKVTEKGVRSVLMFGYGYDPFLMEEDKSRGVEVAQEIIIGSTMERYLASYHGLIHFKYHLLRRCQDLVKLEKGLNADLGEEQILAKCVDNQVWILQTFEDLKALLVVPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIM5</accession>
    <name>A0ABM0JIM5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101847320</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094505.1">
        <property type="nucleotide sequence ID" value="XM_005094448.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847320"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094505.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="10620" checksum="97A33C5389A1FEF4" modified="2025-10-08" version="1">MAILGILCATAGLVVAVIHVVLLVMKKHVTILQLVAGILNCCAFLFFLIAVIIWAADINDAFSTDTDLGYSFALGIVGELFSLAAGIIFIVGWVSGNNGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK94</accession>
    <name>A0ABM0JK94_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101858621</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095677.1">
        <property type="nucleotide sequence ID" value="XM_005095620.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858621"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045865666" evidence="1">
        <location>
            <begin position="27"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005095677.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15333" checksum="21C0E55B172267CE" modified="2025-10-08" version="1">MVRSTVLVAGSLVLVLSLVHLQVTDASDIDDVTRLLMQIDNVLAKFRGKRGCIGYMCSYSHMSSSAGSKAVHNSLMKFLYNCAKDPHCSPGKRKRRSVSETDTPLWSMLRNRDLETFLRRRDIKSLLSGSSSLNKAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKR9</accession>
    <name>A0ABM0JKR9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101864057 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096029.1">
        <property type="nucleotide sequence ID" value="XM_005095972.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864057"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046651414" evidence="2">
        <location>
            <begin position="38"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096029.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="35594" checksum="1A3C141E7F9F7865" modified="2025-10-08" version="1">MSRFLNWRTWTNIRNYTMFHLSSSTLFLLLLPSAILAHRGQWHHDDEYQYNGDGDDYDWGNEYHNDNDLDDGYDYDNGNYYDNGKGCDYDCNETTTPAPSGPVVPQLPSDCSQLYAVCAVINGGANGSSLGQPPNANQTGNNTQGRKLSLAGAQQQDAVANSRFQALIKICEAQTSLYASNCACALLPSACRDQRFRALASCSAYLTTIARRPGCIFGNPNPPTPVEHPPSLVVPIPAPIPVEQPPSPLVPIPVSVPVGQQPPSPGTSIPVGQGQQPPSPAVPVPVAQQPPFLPLFDAARQELCAQAGDAINTDPSLMILCRAGPVLLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKS2</accession>
    <name>A0ABM0JKS2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101864680</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096032.1">
        <property type="nucleotide sequence ID" value="XM_005095975.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864680"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06086">
        <property type="entry name" value="KOW_Spt5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041980">
        <property type="entry name" value="KOW_Spt5_6_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057934">
        <property type="entry name" value="KOW_Spt5_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23288">
        <property type="entry name" value="KOW6_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23287">
        <property type="entry name" value="KOW7_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="17" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="13">
        <location>
            <begin position="215"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="15">
        <location>
            <begin position="800"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="1037"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="705"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="780"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="909"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005096032.1"/>
        </source>
    </evidence>
    <sequence length="1094" mass="120594" checksum="4E505C76A40BC6DD" modified="2025-10-08" version="1">MSDSEDSNFSGNESDGGEDKAGSDDGDASDKNEGSDRNEDSDKGDDSDKNDDSDGEQDNSQDKNLNDDEAEESDGDGEKDDGDEEEPEGEDLDNEEFDEEEDEEEEARPRKKKRKGALGFIIEEADVDDEDDEDDVEWEDGAEEIIDRKSSYDPTEREIESHQRLRHIWESQREDEIEQYYRQKFGNVSTAERYGEGEEMSDEITQQGRLPGVKDPNLWVVKCRMGEEKATVVHIMRKMIAYQFTDEPLQIKSVVAKEGLKGYIYIESYKQTHVKHAIEGIGNLRMGYYKQQMVPIKEMTDVLKVVKETASLKPKAWVRLKRGVFKDDLAQVDIVYPSQNEVDLKLIPRIDYTRLRGIMRTTASQEQQKKRKRRPPQKLFDVDAIRSIGGDFTSDGDFLMFEGNRYDRKGFLFKVFAMSAIIAEGVKPTLAELEKFEDQPEGMQVELVPEKSENEIAHNFAPGDSVVVSEGELLNLQGKVIRVDGNKITIMPRHEELKDPLEFPYNELKKYFKMGDHVKVIAGRYEGDTGLIVRVEDNVIVLFSDLTMHELKVLPKDIQLCSDMATGVDSLGQYQFGDLVMLDPQTVGCIVRLEKENFQVLSMHNKVLGVKPQSITRKKDTKNAVSLDSENNNVQVRDIVKVIDGPHSGRTGEIKHLYRNYAFLNSRLMTENGGYFVCRTRHLVLAGGGKQSAAPAFNSFAPMSPRIASPAHPSGGGERGRGRGGGGRGGMSRRDREIIGQTVRIVQGPFKGYIGIVKDATDSTARIELHSSCKTISVDRQRLSNVSGPRPGGGQTSTYGGRTPSYGGQTPMYGSRTPMYGSQTPLHDGSRTPHSGGMTPSHEGSRTPSGGGSSAWDPFHANTPRHNDMEYGYDDSPSPADFGATPNPATPGYHADSPGPMGPYTPQTPGSAYSPYPAPSPGGYEAQSPGFVGTPSPGTMSSPSPASFAGSPSPMGYSPMTPGAPFTPQTPGTAMDQGLTDWHTTDIVVKVKETHNDARLICQMGVIKDISGGMCVVYLMDEDKMENIPCEHLEPVPPEKGDKAKVIAGEERDATGSLISMDGNEGVFKCDSQEADSNSNILIMPIQTLAKMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JL97</accession>
    <name>A0ABM0JL97_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096354.1">
        <property type="nucleotide sequence ID" value="XM_005096297.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857481"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="19"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005096354.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="62983" checksum="A07E7D7370C9561D" modified="2025-10-08" version="1">MATQTSEQKSAGLDKNNKYDRQLRLWGDHGQSSLETAKVCLVNATATGTEILKNLILPGIGSFTIVDSQKVVGEDVGNNFFLTVDSVGKSRAQVATELLSELNEDVSGDFLEENVDDLLEKNPAFFTSFTTVIATHLPERTLLNLSKVLWEKNVPLLVCRCYGVIGYLRVVVREHTIIESHPDNSHEDLRLDRPFQGLKEYCDSLDLESMNKKDHSHTPWLVLIYKYLQFWQQENGERLPNNYKEKNALKELIKQGVRKNAEGVPEEEENFDEAIKNVNSSLHKTSVPSEVKALFSDPACLDLNIESKNFWVLMRALKEFTENEGNGQLPVRGVIPDMTADSERYIQLQSVYREQAAADATAVAEHVHALLHSIGRDEPLHPDKNRKPGTITDDEVKTFCRNSAFLTVVRCRSLEEEYCPETANLEELSRHVVEEEEEGSTEGDETVLYIMLRAADRFFSEYNHYPGAYDNTMEADIPRLKSCMNKLLHDWGFSSTIKDDYVQEMCRFGASELHTVSAFMGGVAAQEVIKILTGQFVPINNTFIYNAQKQNSTTLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLV1</accession>
    <name>A0ABM0JLV1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endoplasmic reticulum-Golgi intermediate compartment protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101861945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096717.1">
        <property type="nucleotide sequence ID" value="XM_005096660.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861945"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF30">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="8">
        <location>
            <begin position="171"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005096717.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47057" checksum="B48BD59483E7813A" modified="2025-10-08" version="1">MQRMNVVNRKNALKVVKELDAFPKVPDSYQETSAAGGGLSIITFVVIGILVISEVSYYTSTDLEFDYEVDTNFSRKVKLNLDITVAMKCHHLGADVLDQTGQDVLGYGHLQQEPAYWELSPKQKDYQQFVQQVNDYFQEDYHAIQHVLWRMGNPTFAGGMPEREGPKPSTAADACRIYGSLEVNKVAGNFHITAGKSVPVIPRGHAHLAMMMDLSDYNFTHRIDHFSFGDKVAGVIYPLDGSEMFTTYNYHNFQYFMQVVPTEVRTYKTNMDTYQFAVTEKNRAINHSAGSHGNPGIFVKYDLTPMMIRVTEVHRPYWQFLVRLCGIIGGVFSVSGMLNGLVQILMDAVCCRLKWGNYKTQKYDEAVSSLPADPLSQTTSPLLSTEPPEEIFGSATLSDNRPTPVPTPQTPNLSVLHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM50</accession>
    <name>A0ABM0JM50_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 39B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096921.3">
        <property type="nucleotide sequence ID" value="XM_005096864.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852013"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="397" mass="44348" checksum="0038ADD407C1DCA3" modified="2025-10-08" version="1">MGDVNPDVGTTSKADTQEETRFENEAKDGDLSEFGKAGSTSSLLDAVSVYDIFVSYSSDSSDVPREFETVLRQNHPDLTVYCDGDDSKTGSSGLQETYIAADKTHCMVAFLSPGYIQSSQCNEEFNIVLARHYAQDSVLLIPVHTNALETVPRRFTSIPCIDMGSGTGEIALLAEKLADMVMRMKLRQSLCSALIFKQKLQERRAADFKRRFRLEGGQVVRNSTMSVEVKSGDVVYSFAEDCSKLAAIMCAVMKQRAPGLTCHLRPSNPTQRWGQLQSADLVVMFVSDLFISSLALLEELYMVLWRQRLEDQRTIAYFVQCDHGASTPFHLQALPFSVSLEDNLWRRLERASSNKSPRYMVDVDGVRGTFRCTVPQNLALTAAVQDILHLMPHRQGR</sequence>
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        </source>
    </evidence>
    <sequence length="2373" mass="252330" checksum="EA02A5132A7BE9A6" modified="2025-10-08" version="1">MSIILRVGAVKPNGGLESQYGSGDEASSSYTDADVLDIPLPEHTYQRPLPPPSTLPQNSTGYFGLPYQDHNYGMPPPPSPPRPVSPRPPSPLQVNGVVQMEEEVKTTPLVSVVEEIVEDSVTRCICGYLHDDGYMICCDKCSVWQHIDCMGVDRNNIPDSYFCEQCQPRILDAAQAKVMQKRKREELAARNVLSDTSATDTDPEEATNALQSMGKKLPVGKKKALRQKRAGKVKEKSQLKLKVGKSGIQKKAKKAGKKEKENIKATKPRKIFKTASQRMKTGKTKNRLLLTLDQLNGDPWNSNLSPWVDSYEYAHENQYSAGVKDFFSSYLVTHSVDESQMLLDQLQSHITCVADVKKNRKGLRATQEIPAGQAIIEYKGKVMLRHDYDKEHSYVNCFKKLQPFVLFYSRLDVDLCVDARNYGNESRFIRRSCSPNSEVQHTFDGGKVFFLIVSRHEISSQVEITIPFDYNYQECSYCVECACIKNNCAVSRYWKKVKNSHKSAKKELGIKRRRQSTVEIEKTPCEELNASRSPPVGSPNKGNTTPVKALQIKFSTASSPPPPPKLSSPVKLSNVSTLLAASALLDGQLDVASTMGAFDVKDSSLQKSPPPATPLTPPAKPVSSRRASRIMEEPANEEKPVLSLPNATSHTKEKQGKNKEHKTKEKDNKDHPYHHQNEVKKERRLSARRQSQEEPDTVVDCKSEVPAASTNTATSETEDSGTASDCPRKMTREERKLDAIMKAFEKMEKRQERRKEAAAKGDTVTKKGHEPKSKKKEEGENQGGGNGHSRTGSQDGPVDETEVKPEPVQGAADVQMKSPGPGSGGEGEVKVEQPDPVVLSPPTGSVSPVAAAPPGVSAQPEPPVVPRPVKEEQPSPQKVVRRMGKRKRRKSRVQSTSVLSDTASLSTDEGNSNSSFPATPLSVPPTPSVPATPVSAPVPSTDVDNSSEFKFIKTKKHLFTEWSNKHEDENKQEEMFVQCLPSPHVNTMDHLQRRNSQSAGCSKGSDANAAGSAKKRWLRQAMHEVPVPVDFKQGLSVSTDAPDNISPAPRSASPNLAVGLGSPRATSPLDFVTPLKKRRLMRESLSGESSGSVISPSAGVLAESFASNSIGVAPRTNGVKQFFPPHRHSTDDRLLLHKNYPIQNGFSGTIPEERRASASASSTHVSLNSTPSHLNHRDDSGSEASPSSGVFPPVKVDPISVTASSVARMNGLSGVRPSVSSVNVPPPSSSHFPLKLRNIFEKMEVDSSAEGGKEKAPQASSSLLFRENGLGHIGAPFREVISAKLEEDSGIGSSASTSTVVVVNSSSVYNGVNNLMEEGSEAGCVTTKSIMDIDSPATVRVDLNAHEMEPSSLSDSSAVVNLNERLFQLDAVQERRTRDTVGDCQVNSSEDIVNSLPLPVSGHNNIDICDNGCTDSSVVQVRISEPGGGEERAVAGLSRDEEVVDSSQHVNRVSRAGGSTSSVFPDQDEVSVSISSARDAVTTVSVSNAGPEVSNEGISSSGQCSQSAEDNAVSVCDSIEEEQGGVSAGDGGVSGTNCDSHSMEVEESQARQEEEEEMDSDVHTAREEEERGEMCDSASVAHDVEARGNPLACPEVASNSEADVSGEGIVSESHNVEDVVSDLNSADGNVDSTCGESAKELCSFAPAPAETTSNSSTGAVDSFCDSNFERSGRVLQENSVGNDDSSVEGQGVSSSNLLEVRSCHTVWDNDVLGPGEAMSDNAMSSVAQEYSSQMSPITSSASAQGSSAVQSRVSASSPSSKDEGSSSPSVSGSIFLSQAGTVCVSSNDLPSGSECQPPSSSLSALSLSSCPSALSTSLLSPSAGRVEDDLSSTTPGSSASVSPHSGCGLAAPGSSSSISSSAEAAPAAKKKVSLFEYWKRLKDKPASATETKTSPSSGSSSSSSSALSSSLLSSSTVLHQNSFSASRSSTSPSSSSHSPSRSSAPLNPRKHRMPTLATLPLFKSSDPRKDEKRKAKSSKPEKQLSLTERLRLEFGVEDVEEDSGKQKSDTKKHREPGTPPPPPPPPPPPHPPPLHPLGASQAHPHHHQTTRRNVTDVRSDESEVASSNGGAEDSAPPPPPLSASSPYPQTSAAHSFVTPSSHMRAGSGAYSGSSVQPLINGSTGVNFSFHQQQSCISSTSLSVPPPVRASGPVGHDRPGSAGSMVFPSSAPGMPHSPRMNSQPPAYMHPPPPQASQQHPSSSSLSSSSSSSSSSSSSSPSSSLLNPPPPPPHHPTGLPHPSQFHMWPSSGGTAGPSSHTPSSSGAHGSAASVTKQYDYNHRTPTQGPAVSGNVVPSDHPPPPPPLPPRPPPHRISTVSLSSLSSSSSSSSSSSSSHRHYHPHHSSSGKNKSSKAASSSSSSSSSRYIDSRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNS6</accession>
    <name>A0ABM0JNS6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UBX domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005098011.1">
        <property type="nucleotide sequence ID" value="XM_005097954.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846134"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16117">
        <property type="entry name" value="UBX_UBXN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="UBX" evidence="8">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005098011.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="54361" checksum="0B44DD78BE22CFEE" modified="2025-10-08" version="1">MKWFEGGIPSAIQTAKSNNSVFIVFVTGDGESSAEMESRLNSEDVTQLCESKNCVAVKLQADSNDCKFFSQIYPVVLIPSTFFIANSGVPLEVIGQVTSQEDFLAKVKAAIEMQDKMTSEQGATAAPASPPAQQQQQQAASSSATETATAESAPGASADTEEVAGATAADDTSAPEEKKQKVSEDLGTRVERAKQLVDLKRDEKMQKEAEEAKKKEYERRELGQGLQKLKEKQKEMEILEAKKELKKSREEDKLARQKVKEEIARDRAEKAARFGKEKEERAQAQEEVRKRKLEEQAAQAEEQARRSEFARIQFRKPDGSSVNHQFTATETFASVHRFITEHMGCNVSLSTTFPRRTFTPADHSSTLQELQLAPSAAILVIPGNMSTQGVRGSDDSSLSISSITGLLFAPFVFVWNMIASLLGLSGPSAPPARAQEPKSVPEPSATGGDRSLGNTNRRSAAAASSRQEGAIHRFHNAQDDEDPDDKNTWNGNSTQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNW7</accession>
    <name>A0ABM0JNW7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101864617</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005098090.1">
        <property type="nucleotide sequence ID" value="XM_005098033.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864617"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="14">
        <location>
            <begin position="55"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="13">
        <location>
            <begin position="177"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="519"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005098090.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="62920" checksum="96274E7447CE57A6" modified="2025-10-08" version="1">MAASTDVGKTTQGEAKFSVSGPKEKTTILKRRYDKSGSNSNETVSRKEAKLDRSRSCPYLDTINRSVLDFDFEKLCSVSLSHINVYACLVCGKYFQGRGNNTHAYTHSVFEGHHVFLNLQTQKFYCLPDNYQIIDSSLDDIIYVLNPTFSDIMIRKLDRNPKLSRAYDGTTYLPGIVGLNNIKANDYCNVVLQSLSHVAPLRNYFLREENYYKIKRPPGDQAFLLVQRFGELIRKLWNPCNFKAHVSPHEMLQAVVLCSKKKFQITEQGDPIDFLSWFLNAMHSAMNGTKKMNSSIISKTFRGKMRVYSRKIPSVDLSEAEQAKLIETEDYQEKVFDMPWLYLTCDLPAPPLYPDESRENIIPQVPFANLLTKFNGVTEKEYKSHKDSTMKKFELTRLPHFIIIYFKRFNKNYFVFEKNPTIVNFPIKNIDFGDLLSSEARSQHKNTTYDLVANVVHDGEPAQGKGSYRCHVLHKGQGKWYELQDLHVADILPQMITLSESYIQIFEVRKDIPNPLYNPAGASEVEEGGVVSMEVSGTDGSENNSTEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRA8</accession>
    <name>A0ABM0JRA8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Squamous cell carcinoma antigen recognized by T-cells 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101863819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005099708.1">
        <property type="nucleotide sequence ID" value="XM_005099651.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863819"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12391">
        <property type="entry name" value="RRM1_SART3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12392">
        <property type="entry name" value="RRM2_SART3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008669">
        <property type="entry name" value="LSM_interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034217">
        <property type="entry name" value="SART3_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034218">
        <property type="entry name" value="SART3_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF25">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05391">
        <property type="entry name" value="Lsm_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="656"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="751"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="551"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="826"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="618"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="894"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005099708.1"/>
        </source>
    </evidence>
    <sequence length="920" mass="104928" checksum="580A2BE7C6774EC5" modified="2025-10-08" version="1">MASLSQMDENIPVGDEEEKMEIMEASKTTKNGDSDDSDSDSGDEDQKNEEKESSINALNKEISQNPYMYDNHTERIKLLREIGDLNRLRDARQEMSTHFPLTEELWLDWLRDEITLVATASDRSKVEELFEKAFQDYLSVPVWLEYVQFAIGRMAEEEGIQKVREAFERALASVGLHVSQGANIWEAYREFESAVTAGLMPQPGAVVSAEQEEAFKTQNQRVVSLFKRQLVVPLLDMQSTMDEYKEWLGEDSVDSETQASFDKAHHVLKDIQQFEDQLISTSGSEQLKSYQDLITHEQRKKEPARVVCAFERALKDHCLVAELWQQYTAYLDKLNSGQQIKSGYERALRNCPWSSQLWVNYLLALERQGTEFVKMKEVADKALQVGFSEASDYLSMWSAYCDYLKRRIDWSQDHTEQLETFRLTMEAAVDFMFENYGKDGDPEGRLRQFWAYIEAKFCKNQERSREIWNQLMQEGHGAEAGMWLQYYQLERMFGDNKHCRKILQRALNSVTDWPESITQAYINFEREEGDLEQFDVALARSQAQLSRIEERRAKAAEKDAVIQDHKKKERTDRKAQKKQQQPDTNSTQQSSQNAGNKPGKRKLEQGAAGDFNEAAESVNKRGEPPSKKAKPEAVEKSDASENHGETVQHDPSKDNVTVFISNLDFSLEVDRLKEIFHKCGEITDIRLVSNYKGKSKGFGYVEFSDSNSVLQALRLDREFIDGRPMFVSRCEDRSSVKSGPQFKYATRLEKNKLFIKGLPFTITQEAIETIFKEHGKLKDVRMVTYRNGRPKGIAYVEYENESCATQAVLKADGLQVGEHTISVAISNPPERKTPLSTRMDPFTARTPSLGGGKKETDFRGKARTQVSLVPRALRQQPQPGSSAKVASQKTEQKSSASSSASSGSASAMSNDDFRKMLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSB6</accession>
    <name>A0ABM0JSB6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005100391.1">
        <property type="nucleotide sequence ID" value="XM_005100334.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845853"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005100391.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30934" checksum="BA0DAF7793DE1F54" modified="2025-10-08" version="1">MDAVEQHDAFFNSFNLVRGPCLGSGAVGEVVLASAKHNSSLKVAVKIVTFETEGCRGDFLSEVGFLRDLRHPRILKMMAFAMDDHHGFMLSTYFKNGTLRDTMSSDHPVEEPRILRHILDVASALQYIHGLHIFHQDVKPRNVLLDDQDRAVLADFGIARQASDSSTMVMKWRTTPGYSGPETRKRRPMSPFKLDMYSLGVCMWMLIYRQRSVGIKDLLAFSDQCKNVKEPYRRILRQLLRKDPNKRWSAADLLRFCVWNSLCAPSLMSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSR2</accession>
    <name>A0ABM0JSR2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transducin beta-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101862190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100638.1">
        <property type="nucleotide sequence ID" value="XM_005100581.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862190"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042410">
        <property type="entry name" value="WBSCR13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44321">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44321:SF1">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005100638.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="49295" checksum="FF02B54077B0A278" modified="2025-10-08" version="1">MAVEQASIPLIAVTAAVGAIVLLFILLCNVLRRDKQQQKEEDSQANDVAEGSPTEKTNNKKQQKSAPKNVKKVAQAAFSHPWLAGTLKGHSGRIVGLDFSPNGKYLISTSEDRALMLWSVKEFQQRDHKYIRGNVDLDSATHVAFSPDSKAFITSLANENAVRIFRLGKKDDGSNNVAISAAVTFPKKQDRDIIGVGISSTGRFIMTCSGDTTILVWDLKGEVLATIDTHQMNNSCGKVSPCGRFVASSGFTPDVKVWEVVFDKTGNFKEVKRAFELKGHTASVYSFDFNNDSRRMVSVSKDNTWKYWNTDVQYSMGQDPKLLFTGTLSFPCKSIALSPDGRTAAMASENSIAFWDAVSGKEEEVIENVHSEPMLGLSFDVSGRYLVSAGGKHIQILHNVTGYHATIAELEEKLRTATGPGMKERIQQQLTDARAAIDSILTPSNGHTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTJ2</accession>
    <name>A0ABM0JTJ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gamma-aminobutyric acid receptor-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101862956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101144.1">
        <property type="nucleotide sequence ID" value="XM_005101087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862956"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17232">
        <property type="entry name" value="Ubl_ATG8_GABARAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101144.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14390" checksum="AD554A4E166439AB" modified="2025-10-08" version="1">MKWQYKDEHPFEKRRAEGEKIRKKYPDRVPVIVEKAPKARVGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNVIPPTSATMGALYQEHHEEDFFLYIAYSDESVYGSCEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTV9</accession>
    <name>A0ABM0JTV9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101854875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101363.1">
        <property type="nucleotide sequence ID" value="XM_005101306.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854875"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="106"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005101363.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22433" checksum="003036193468B483" modified="2025-10-08" version="1">MNSTPNGLPGTPSPSPSLVSSHTTTVLNNGPSSSPIAVTSSSSSIVARPTQPEQIIVPVGNMINSNKVSENSSTSRQTPSSASSQASASATLGSSATDSRGVLDRTRLRELVKEVDQLEQMDDDVEDVLLQVADDFIENVVSSSCQLAKHRRSNTLEAKDVQLYLERCWNMQIPGFGSEEIRPYKKSVTTEAHKQRMALIRKSLKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUS1</accession>
    <name>A0ABM0JUS1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">U1 small nuclear ribonucleoprotein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101858643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101982.1">
        <property type="nucleotide sequence ID" value="XM_005101925.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101983.1">
        <property type="nucleotide sequence ID" value="XM_005101926.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858643"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12476">
        <property type="entry name" value="RRM1_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="180"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005101982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101983.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28337" checksum="5E92FBC004DCCA58" modified="2025-10-08" version="1">MAVHPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDIVALKTFKMRGQAFVIFKEINSAANALRSMQGFPFYDKPMRIQFSKKDSEVIAKMKGTYVEQPKRSRDKHEDEGGKRKKRSKAQANVEQNQAPVSQGPPPQIAARPPPQLNPPVPVAPVGMPAPVAAPPAVSAIPEQPPNQILFITNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFETDVQAGAAKDALQSFKITPTNAMKITFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUT7</accession>
    <name>A0ABM0JUT7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase-like protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102025.2">
        <property type="nucleotide sequence ID" value="XM_005101968.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849383"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102025.2"/>
        </source>
    </evidence>
    <sequence length="302" mass="34307" checksum="09F855B4B13F5C4A" modified="2025-10-08" version="1">MSGKGKVVVLTVLVVGFVTASVFISQSRSVKAQLVETVKVMRKQQREWFQAADNRQADVAASEELAAVRRQGISQNLAGVDISKMDSDEIIHTMHSILDNSDTQCSRKLRMGKIGDGGWEICDDVDVRPRHPCIVYSFGINNDFSFDDNTAKYYGCHVYSFDPSMKQESHNRSDKVHFYKIGIAGETTVNKRGWKLYTFSDIRKLLGHVNATIDVVKIDVEGAEWSSLKHMVASGEIKHFKQLLLEYHVATIKRDSLEVVQSVESQGYKKFYTHKNPACPVWIPKFPSVRTKCYEVHYLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVL0</accession>
    <name>A0ABM0JVL0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101852105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005102568.1">
        <property type="nucleotide sequence ID" value="XM_005102511.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852105"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005102568.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="62523" checksum="E7D0F97E3818AE32" modified="2025-10-08" version="1">MEVSSRQIVTFAFASRSLVLLLQFLANLLLPDHDADVFLPPVDKREFSVLDHAVHFLFSGLMRWDAVYFSHIAHYGYTYENCVAFFPFFPITVSSVAHVLSYLGVLHLSSWILLAAVITNFILFILAALSFFHVGKHALGDPQVSFFATILFCFNPASIFMSAAYSETLYFFLLVHALLAVNAKAFYAASFLIGLSVLTRSNGLVGIGFVLHSLGNSFFKELSSIHWCGKKLTYSQIVPFYISCIVKTIFRVVLCSIICSAAFFAYQFFIYTQFCTRKGSVFVPEHLISYGRARGYNIVGDSPSPWCNDTFPMSYTNIQKHHWGVGFMNYYEVKQIPNFILAFPVILLSVRSCLFFVRKSGKSFFQLGFGNSLNYFMRNTSQARDKKRDSLSDDEVDMDEIDAKSQVWKPSTAEHSHRIVVYIFHLIGLTVFGCCFVHIQVLTRLLFSSSPLLYWYCGMLWYRDRASQMPSPRRRTQSHPKVLNSSSWMDVATHKIRSTIVKCQCSPLLDILENWANLSLEFQLVVIYFVFYFIVGTVMFSNFLPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWV1</accession>
    <name>A0ABM0JWV1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase domain-containing protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103417.1">
        <property type="nucleotide sequence ID" value="XM_005103360.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850425"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="56"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005103417.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49071" checksum="60A62352790DD021" modified="2025-10-08" version="1">MQIMALAQPASRHIAVVILAVASYHYLQVYISRKDLPKPRVGGYFHPSFRNVAETFRNNLESGLETGASFSVYQNGQALVDLWGGWADLNSHRHWQEDTVALTWSMVKGVTALVVARLVDSGVLEYQREVHHYWPEFGTEDKRNITVEMLLSHQAGLAVLDEQIVILDYQHNWPKVEKILAAQKPNWPPGTAVAYHAMTWGMYVDALVRKVDPQHRNVSEYFRQEIAKPLGLDYYIGLPPNLFHRFAQFREYSFWEQRITYANVVPAVLGPYLLPATLSIDTGVQLARANNPDVLQIGVPSFIGVGAARDLAKLYDYLGNNGTVGGYRLLSNSAVKLLKEPLTKDLPNLFFVFYPYSRGLFLKKNKQGHLMVGHSGYGGSYSAADTDSGLGMAYLTNHVSFHQEDPRADSLMEAFYECYETYVSAKKKNGQDKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXH2</accession>
    <name>A0ABM0JXH2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101855660</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103854.2">
        <property type="nucleotide sequence ID" value="XM_005103797.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855660"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005103854.2"/>
        </source>
    </evidence>
    <sequence length="436" mass="48416" checksum="0A1F29FFE7F81B37" modified="2025-10-08" version="1">MPKGKKKGKGKGKGKGKGKGKGKGKGKKEGSGGNDGETKKLLKTYERNCALTNSQMCPGIRKLLKAAAEDNKVLTKFILEPVPVEKEGDMPVLFDPFLQSLRQERYTHIQDIHVWDYPMAYENIATLALFLEKPFYPIRLLELMDCLIDAPAVPRLASSLAYCDVLTTLVLDYNEFGDKGCQHLCEGLERNVTLLSLSLCYCDLQIESGKYLGHILSTTALRELYLDGNELQCEGTMELIKLCVDQGEIEAYQREEEAKRKAEEEALLAEQETQRKYDLTSAGDYSGSDKEGNSKPGSGKKKKKKKGKKKKKSKEPAGPPPVGPWVHKLHLADNGIDGYGDMGHFAPIICMRLFKKLLMNSKCVEELDLEDNNIGELGGREILDGLEFRKEAKLGGVKVRTTHLMTSDTFNSIVKLGNGLTKKGKKKGKKGKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXU7</accession>
    <name>A0ABM0JXU7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-amino-acid oxidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104084.1">
        <property type="nucleotide sequence ID" value="XM_005104027.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849555"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046686414" evidence="1">
        <location>
            <begin position="19"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104084.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60216" checksum="F84429C1A15116D8" modified="2025-10-08" version="1">MSSAFLLLACALVISVHADGVCRNRRQCNKEVCGSSYDVAIVGAGPGGANSAYMLRESGLDIAVFEYSDRVGGRLFTYQLPNTPDVNLEIGGMRFIEGAMHRLWKVISELGLTPKVFKEGFGKEGRQRFYLRGQSLTKKQVKSGDVPYDLSPEEKANQGRLVEYYLEKLTGLQLNGGPLKREVALKLTVPDGRFLYDLTFDEALDLVASPEGKEFTRDTHVFTSEVTLDASAISIFDDHLGEDYYGSEIYTLEEGMSSVPQGLLQTFLDAADSNEFYPNNHLKALRRRTNGQYVLYFEPTTSKDGQTTINYLEPLKVVCAQRVILAMPVYALSQLDWKSLRNDRATQAYSAVRPMPASKVFMTFDQPWWLQNERKSWVTKSDTLFSQMYDWQKSKASGDYILIASYADGFKAQYLRELKNQGEDIPGSDPGYNQVTAPLKDAILDHLTEAYGVERDSIPEPVTAASQFWTDYPFGCGWITWRAGYHFDDVISTMRRPSLKDEVYVVGSDYSWGLISSWIEGALETSENVINDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY50</accession>
    <name>A0ABM0JY50_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101858205 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104296.1">
        <property type="nucleotide sequence ID" value="XM_005104239.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858205"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM3 N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="ZSWIM1/3 RNaseH-like" evidence="2">
        <location>
            <begin position="217"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005104296.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="88024" checksum="65B5150760433009" modified="2025-10-08" version="1">MDDLEAKEKAELLVLTVAEPVLKVGDEFSCWEDFFESVKKYSESTNQPFVKIGNKSVAQANKFKQDKLYPEHLKIVQQTYGCTHRGGNELTSSAQRKRKSFKIKCSAKIHASVDNTSHRIVVRTLNNEHNHIISQEHFVQYPQNRRLTEEEQQDVQELAKLKVSTRQLKEHTSRAYGKNLTLHDIRNIKAKARKKDKTNDNGCQLNDTDLLLLYLEEVRTEDPGSTIEIAMDDDMTMSFVFFQDSLMKEASDKFSTHILVDCTYYINDRQMPLVTLMGFNGSNESVILALCLLRLKNKETLLKVFELLLRVNPSASGVYTFMVDKDFTEITSIKEAFPDAPVELPKFHVMKAMEQKINSLQCSTENKDLLRNACFKCIHATNENIYEQGMNSLAEINPEFFRYFVDNWHGVRTMWVDFHRWEKQNLGNTHTTSNHLESFHQKLKSEIPTKASLDVMFRNILLVVNILRNEHAGRLFNRHVKVSEIEMEYGELKKKLTPHAFEYTVNMLEKSKSMTCEENEDGVRVTDTKQRTFNVKGDVCNCLAEKQLPCAHVYAARRKREMAVVTLDLFQDVWLLPDPQAVPLFEGSSNVSTSVPKPRILNKREKYRMVKDVTDSINGKMSELSTHKFQLVLQRLKELDSILSSGSCDREQERAEEAGQLGAVERIEGEGQLGTMERIEEGQLGAVERIEGESIVKIDKRRVRTANVLDVGSLLSNIKRPLSVPKRGRPRGSGLTVFGGPRKRTSALKKPTSQHKKKCTEIVIEEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYK1</accession>
    <name>A0ABM0JYK1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104560.3">
        <property type="nucleotide sequence ID" value="XM_005104503.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858727"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104560.3"/>
        </source>
    </evidence>
    <sequence length="360" mass="38028" checksum="0E4AEBBD6B87CD21" modified="2025-10-08" version="1">MAAQVLPAAGPTGGSFLDSPVFNSRRTMPPPNAFSRRREIGGGANDSPPPPIADLRFDSSDLDASGSPLCTPNTSFIQAETPDSGFSGLVSSTPALKTPESDQSASASVTPTSGGSSSGSRKRKTVNFDESQTSVVMISPDDLFNTYSKLQGPSLESRDNPFLPGGDLSREAEDLLSRATIIRDNFYLNEEEKRTLQLQQQQEQLLQQQQQQQQQHQQSEQPQKQARGGKHVQIVDHLDGADHGNNHNNSTSEHAQTNNNSLLPGDVEERISPQTAGATAASPSPHADGDTPRENGKVGDPSAPVSADGVKVSIPADGEGQSKPGGGGAPDSQGNNGPATGDLQVQDAEKKRRNKCCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ35</accession>
    <name>A0ABM0JZ35_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862292</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104924.1">
        <property type="nucleotide sequence ID" value="XM_005104867.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862292"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104924.1"/>
        </source>
    </evidence>
    <sequence length="758" mass="82776" checksum="45CE930EE67DC39C" modified="2025-10-08" version="1">MTGGFSKVYEQWLKNSNHDDDDANDGDMDEETPYEDPEGIADLMDSDTTEDEDGGSLMNRSPFYERQWTDKSAELISDSAPILLDDDDEIFPSEKQQFEEEPPILEPVSAPTHDSKSSQSQHSLVSPPRSVVRNYSRESMVRSSEKKTMKTYSRKSRVEENAQSLNDCLKKSKESGNIFDKFSPFPAGVEDVPPPLIPSPEALRLHSESPTGVDQPATTSDREHPGCSPDFCAMEADSTSEISGDSVTSCNVRNKNPVAGDVVVECDSTCMLGGSPAIVSPSSVLNGESEVRDQGGGSGVEADAGSPAEQARGTTFVTELVRPDPVAASLETNESWCEQDASRDGSLPSLDHPPCSGVSDASFVPASPVVSVSPPAPPTSGSPCLQVSVETPMQDEPPVLSAIPAPITSHSRTSTKRHTIDSPYTYSSSGKRPHTFPSPKVEDEAPDLECSAPPLLPLMSETVITLTSPDGQSKSSSHKSSKQSSLSSRRGREQRRAKRHRHRRITVPSEDLTSDVSHLPEELQQFVLSTRQLSAMQSTLHTLVLTLFPQLKAEVSSMSPESLRFELFVKDMVESLQQGDDQKSEEHPPLTLTIKCEKDVGSYVDQMAGKAAQSSDASRNHSSSNSSPQCFVSNHSQRDEPALSSHLSTRSRRPTRQCTIREDPFTSEVIPQFSQLDLKSEEEGGGLLTLKPVRVCVQRTSSEHLHKFCCLCCDLLQLLLPELPVSLCNELSNSPSDLLTFIENVVASNQRERRKHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0K0</accession>
    <name>A0ABM0K0K0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/potassium-transporting ATPase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105923.2">
        <property type="nucleotide sequence ID" value="XM_005105866.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853961"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005105923.2"/>
        </source>
    </evidence>
    <sequence length="327" mass="37049" checksum="09DF8C5391D987CF" modified="2025-10-08" version="1">MTANPYYPVTTVSDSSHLADDEWGLTMPSVQYAKHSRTKRFKSACEGVKNLPRCAVIIFVTVCVFILICIIIAVAASNRGEKHPTGNEPMRVQQTLGLNFYPVPADISTVIRFKKHSFKKDEPIKKTMDEVLEPYSHAHQQDMDFTTCTHKVSPYNKTCMFPLLKFGQECTRSRDYGYAVNLPCVLVQLDLPADMTISPINENSPLWEVAQTNAAVQKHEGDPSVVPFSCEGATKDDRKMFSSITPVGRKKKHILYSPEDAFPSFFYRKRDLTREFLKPAVMVQFTSLLDLRITHVKCTAWGQVFHQDGKMVDHGLLETTFAIYIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2A5</accession>
    <name>A0ABM0K2A5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101856372</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107056.1">
        <property type="nucleotide sequence ID" value="XM_005106999.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856372"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107056.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26034" checksum="8680721230FC3B3C" modified="2025-10-08" version="1">MASDARPPRSKNLPTILSKLKAMSSSSESRELNSRAGHVSRNNSTEDGGGRGRPEPRGTPRLAWASRRDSSMSTISSLGNGPGEHTTPGKPLLARIPSIMSLGGSTSPWGKRLKKKRDAEEYAAQKLARQKAEMIAFYKGTPMTDDRATSTEILRFLYDLWEPQLCPSYRRDANISTSCRQDLRSARRIAQAMPRRAAKLHRARLVIDTCTRMSVSGGAPDSARGSVPSRPQSAKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2B1</accession>
    <name>A0ABM0K2B1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C8orf74 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107063.3">
        <property type="nucleotide sequence ID" value="XM_005107006.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857975"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032727">
        <property type="entry name" value="CLAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457:SF2">
        <property type="entry name" value="SIMILAR TO 4930578I06RIK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107063.3"/>
        </source>
    </evidence>
    <sequence length="320" mass="36292" checksum="BB9AB95AB8E1E534" modified="2025-10-08" version="1">MAANQNFEGCTMLSVVEVQQIVKLPPIPAKELVAEKLGIPPYNDVKDPQKAPFINFIYDNIIFAVEKGFPWDHVSLVVKFAHEFLKSILVENHKLPDVIKDFQRKADILTALCDRHKKQYTDFVYDTVLCHYNLYKYVFSHLREIVKPKVEKEVLVPPIPPPLSQGQSVEVWEYQQKVKDVEVRETEAKEKLKQTEESQKEKLTPHKNIEDVKDVPVPYSKMSLEELVKDVLKGYVETKQMELKGKADEMVQDLAFKLDKTALARPAVMGSPPRFKPKSPVPSKASSNNNSLKADKDKSSAKSSRSKSGRASAASSKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2P2</accession>
    <name>A0ABM0K2P2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription termination factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107364.1">
        <property type="nucleotide sequence ID" value="XM_005107307.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849956"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF50">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="516"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="931"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="817"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005107364.1"/>
        </source>
    </evidence>
    <sequence length="1105" mass="122930" checksum="52A8532EF00F4EC8" modified="2025-10-08" version="1">MDLNMQDSKGLKMRPADFGNRLTLKKTTIAVKKDNASGDDEFDKKELNKETVASHLGADTNNTPKECLKDNTAKTALFASNHEKKDMPMGVRPKESDNMWVRRDEKSIPGNMQKQDGGSRVQQYHKVVPPKPTTDTKTVQKISKQPESDLLKITPSESKTERNEEAKSKTGANYANDVRPKESSAKELSKSSMKQSHHRDDSGPTIGLKSDDHGLKIKSGVSVPQRIDVAHLLKQKDSFEIELQQIQSRLKGIKLDCLPDNGKRIIDSIEAKKQNIRKIDQQIEVYMSSAKQSQGVGQSGAVPMKNSGDGAKVSDRSTSAVDTQVNRVPVSRVMEPVPHSGNDLKTVSSSSRHKVIHPPQLGTQGKQVIVVKKGDASAASVQGKQVFVVKKGPSSQVQMSNSGVLPSAHGSSGGVSMAPGPQRQAILVQQSVPHLSHLPLHLQQFFAANPQAMTLYGGRMTAQRLREVGSITTEAIDKLHKQLETCPSDETETPDPAGLNVTLMPHQRHALAWLSWREQQHPPGGILADDMGLGKTLTTISHILRLKQAREEATDDEWQSRDKEVEKLNKAIKKSKATLIIAPASLIHQWGKEIERRCRRGSLKFHLYHGPTRETNIKRLTDNDIVITSYSIVAKEVGQDKSESAEQPATDGAGEEQEDADGPSKQSELPLLLRIGWERIILDEGHNIKNHKSVTAMSVCRLRAAYRFVLTGTPIQNNLLDMYSLLRFLRFSPFDELKVWKRHIDSGRGDTKRLNTIVKALLLRRTKEDTCKEGKPIVDLPNRSSQTIDVHLSEEERRVYDKLFRRTQRRVQEYIQRHEEKGSGVSGHSRSLEGAPAHGTPLDREAQKFGPSATRSTGSDLLVLLLRLRQCCSHLSLMKEQVDTESLETDGIELTLEEQMRSLTLGDFTDEKKEENAPLASKFDKKAMSTKLKCVLDKIQTVSSADSSKKGDKCVIVSQWTQMLEIVGHHLSRVGILYSVIQGNIPAKKRMDIVDDFNSNPRGAKVMLVSLRAGGVGLNLIGGNHLFLLDNHWNPALEEQACDRIYRMGQKKDVFIYRYLCKDTIEEKIVALQQRKMSLAKSVLSGSGVKSQKLSLSDLRMLFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2V1</accession>
    <name>A0ABM0K2V1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cilia- and flagella-associated protein 57 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101858441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107476.1">
        <property type="nucleotide sequence ID" value="XM_005107419.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858441"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052993">
        <property type="entry name" value="CFA-57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="6">
        <location>
            <begin position="365"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="812"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1070"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005107476.1"/>
        </source>
    </evidence>
    <sequence length="1210" mass="139090" checksum="80A4E4FBADEE622A" modified="2025-10-08" version="1">MSIALAQERYIFGVKRGVSGNTCYHDEQTIVYPAGSNCILYNIDQKSQKFIPGTDKSEGMTALAVSPNRRYVAIAEKGEKPTITIYDLHSLRKKKVLSSPEVQSGEYISLAFSPDSKYLVAQGGKPDWTLLYWTWEKSKVMATTKTSNPQNPNSEVYQVSFNPQDNTQLCVVGNTVFRHFRYSEGNLKPFNFQKMEPQNYLCHAWVSEERIIVGTDNGKLLLFEAGEVRNEFNLAPNADNSKTTSEEGSSLNPIQVTSLVSYSKGFACAFGLGTVYLFEKTDDKDFFKKAREIMIPPDSCNSQDPTLSQQQFINCLTVSPSEETLVASTDQAQLYYLTLSSADLSKGDQAQFEVLSQVFHNAPITGLDVCIRKPLIATCSLDRSVRVWNYETCNLELYKVFAEEAYSIALHPSGLYILVGFSDKLRLMNLLIDDIRTFKEFTVRGCRECSFSNGGHMFASVMGNVIQLYSTTTFENINNLKGHNGKVRSVVWSADDSKLISCGMDGAVYEWDTSTGKRTSESVLKSCSYTGVTVTPDGKTTFAAGSDKTLKEIADSQILREVSAGDMTLTSVALSHSGRMLFAGTVKGTLWSLKYPLAVPGDWTELQGHGAPIVKMKITYDDQFLVSIAEDASIILWKIQDKEGRGLKRDKEVGWAEEILITKSDLEEKNSTVSDLNSRVEELKMENEYQLRLKDMTYNEKMKELTEKFIQEMESLKTKNQVLKTDKDKEESKHEEEMAELMDKHAKELQDLESANNQKLMLEYEKFQEQQAKMMKMQEDYDRQLQEMEESKERALEELTEYYETKLQEMTTKLEQSNDEARQQSREYEETKKQIEEDSDREILDIKHQYERRLRDEKEANMRLKGETGIMKKKFTSLQKEIDDHKEEIKKLNAENSKLNNVIRSLEKDIQGLKKEIQERDDTIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPREMDIKNMKEQIQEMESELERFHKQNTQLELNITELRQKLKATDKEMHQERQRVRDVEATVKRFKTDLHNCVGYIQDPKMLKESIKALYQKHVQEDIKTESASVDADIQKEFSRQKEHLERSVASLRKKLEKDSEIHKADNVRIMQENVTLIKEINDLRKELKLCRVLIHDMEAAMGLDARSKKSGFSVQLPPKPAGPLVEKELEEHKKVIEMQQMELKRLRDEIYDLETAHGSRPPSGQRLPPVNTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2Z8</accession>
    <name>A0ABM0K2Z8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101858891</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107564.1">
        <property type="nucleotide sequence ID" value="XM_005107507.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858891"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107564.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="71383" checksum="B81C560025354D60" modified="2025-10-08" version="1">MFPISQSGLGGNQQRGSRKNEEWTTNCLQLVYSAHRTLSAMCENVDTGEDSAPKEPPGLRCTPVSEELAVEQMAAVFMEQCQALTQILSMPMEGLVRLPLGVILKLITRSLNMSYKDVTALPSLKDLASVLPSLQQSSMEVLCSLILCCNTNLLPQSRLILDLLQRVLVSTGRMESHEKSTTRSWVYRVLSEWLKMAGMGRHFLSHLNYFIQEIVSDVQFIDKPHKEANGIGTAEATAVDDAVSSRATGKGKKKKKNRTADSYKDLSVMNNLNSGVDPGLCKPYVAEATFCGLELSKVILERGQFILLQKLVRHILETTSTLQRTDASSHSAYSQLACRLGLYHVVWVCSQVPLDNGVGTADTVAHFQQTNQALSLISRASHAGSFVEVRSFCQERLFSMHSLGSLSRPIVRKVLPDDKDESQDLSETVREVEKLTEENDSLRKRMLEVEMERHNQARLVASLQQEIVTLRAAQIQERNNAEESEHDSPDDQDDVVLPDNGSEMEVNRENEEEEQETSLAETSLKDLEEEKEVHTKMEDARKGKRKRKGKKKKSLQMNSSTAETPELDSKPGSHSNSGLSPQIKKRAVSSDKDIEKSDVKKMRVVTSNQDTKTEEIQTEPDPEHVQEMLLDFVDAEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K502</accession>
    <name>A0ABM0K502_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AN1-type zinc finger protein 2A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101851444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108897.1">
        <property type="nucleotide sequence ID" value="XM_005108840.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851444"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005108897.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30002" checksum="FC892AE9FC5E11AB" modified="2025-10-08" version="1">MEFPHLGQHCNESTCKQLDFLPMKCDACSKIFCRDHIMYTSHKCPDSYKKDNQIPVCPLCNLPIPLRKGELPDVVVGRHIESDCQSDPAKERRKVYTNRCSKKGCKQKELVPVKCETCRLNFCLRHRHELDHNCKGYQNSGRAVSNAGAAALLRAQQATSSKKSQNLSSSSSSSSGHPSNRNSNSSVPRANNPAALSSLQGTLTEDEALARALQQSLGGSSDALPEGMSQQEREDFLLAQALSASEQEAARSRQRPAQTAGNRQDQRSACTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6Y7</accession>
    <name>A0ABM0K6Y7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Uncharacterized protein LOC101855298</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC101855298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005110186.1">
        <property type="nucleotide sequence ID" value="XM_005110129.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005110187.1">
        <property type="nucleotide sequence ID" value="XM_005110130.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005110188.1">
        <property type="nucleotide sequence ID" value="XM_005110131.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855298"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041384">
        <property type="entry name" value="DNTTIP1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026064">
        <property type="entry name" value="TdIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049121">
        <property type="entry name" value="TdIF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399:SF2">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18192">
        <property type="entry name" value="DNTTIP1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21229">
        <property type="entry name" value="TdIF1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNTTIP1 dimerisation" evidence="5">
        <location>
            <begin position="934"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="TdIF1 C-terminal" evidence="6">
        <location>
            <begin position="1089"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="732"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1049"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1074"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1251"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005110187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005110188.1"/>
        </source>
    </evidence>
    <sequence length="1290" mass="138697" checksum="6AB53B91F8F5BA5E" modified="2025-10-08" version="1">MSGQNSSSKTVAAILKQHQDLVAAREITTNQQHQLPPSQQNKKKTKQKTVHKQAHIINHLTAVKNRNIQSSNVASVSQTVNRTSVASVSQQEELGLGKESKPTTTTKASSLSRDLSPSRITAQMKKVMPDPSSAHPNLLLSALQGNMPDPMGLFTPSKPESIMVSTISDVHNTATENWKTTVHSSKSPVDSQLTTTVFSNSLTPVTVFSCPEETNVKSKSASNNSPNLPTVENLLALSAGTIQTINVSHVPKATIPTTSSSLGAVSENTTPGTSSSPSVSTRNAMEVAQQIRMEANGQSASALRTGMQQQLRSQIQGSRSIDAHLASQQNPVTVAKVSSQKAARHEKEQKPLEVSMPLLAAKLAPSSIPGSTAAGSRASLHVKQSTAVGDAPLLLSSLTPSGATAIVVPTSSVAKVSRKSPLQKVSESGNFEEMKKQLQMNKQTSSQVGKQVPQSLAQEEVVLSSSDIEGTLAAVSAAADQIWGLGHGSPRMELSQVSAAFDMHPQLEKMASRSLTSNALLEHTAQTDHASKADGQSQTRNELVSHKLNWNTTLPVRGVNFDQRKTPPDKRVKYEVVEDHRGLGTNQQTSPAMSKYGAGDSKLTAIDVDLDVGHLPSIVAEEAIHISKTVSSAGQKMHANLSVVNVKDSFPATSHFLQSSHIPISVNNVSGSSSVPSTMAAGKSLSDASASMAGEVKLLSGSSPFVAGVSPMHSAMGSSSLPRSNPVMFSAAPMSSSSSHTGMASSNPPAYESSSLPPPYSHPAHSFAAPDHHRHNPVSGKDSNHNPFTFPTSGLTVISDSSGHGFTAFALRSGTGDGPARSLPEGRLASTVLSKAHSDTSALNHSHKHNNSVPTEAIPRLVPEASVKLEELQGFNHIQEAKMQDELLPIQPFNQRISNLSCFPVMNSTYRAAYRSHAVAVQRARAGVIMSTAKSLDVLRQNLQRNINKEISEIIKRYTDKYFQPALENIRLNNNEGSLGDEHINYVCRQILEEAKSEYMSMSGRRSATPSDIPDNVSDSGSTSGRRTFLKRGRISDSDSERGSDGGFKRKTVKRKGRPPVHSSGRATPSKQPVKREGPRWDPVRLKPDTLFVMGARANKALGLGNTRGRLYIRHPEVFKYVGDQEDKLWLYEHNLMPAAGGKAYMLLLEDIEELSRTDEYKDSPSLMMHECVGFTVPEWMLVKMKTQMNALRSDKKPTTYSSPGPTEAEEKNQKILPFSSFTEVSIKDEPQLSPADTEMDFLSTADNEDTQPSSAVSPFTVTGGFEDGTSPSPSDLDPIEETSGHHLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7E2</accession>
    <name>A0ABM0K7E2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110516.1">
        <property type="nucleotide sequence ID" value="XM_005110459.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853416"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="182"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110516.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="44020" checksum="8CDB24D3D76D9888" modified="2025-10-08" version="1">MNVPVFIDIAVPHQTLELRSFFKSLGAEISEENAESGLSTDLKNILEASKFCWNLNNDTEIEMVFSGIISLLLVVPVAEAESVVTLFCEKVGKLPDGDKRAALRLRMLSNLFYGLDEEASLRYVVLCSMVRLAGQNDLLSMVPVDLDKIKKWIGQWKISSAKVQVLYRTMHESLIACNMRELATKVMIELLGTYTEDNASQARDDAHKCIVTCLADPNTFLMDHLLSLKPVKFLEGELIHDLLTIFVSGNLGQYQQFYKNHTDFINSLGPSHEENVRKMRLLTFMQMCENRKEMDFSLIQEEMQLDKDQVEEFVIDVLKTKAVRARIDQIQEKVIVSSTTFRTFSKHHWQIIRQHLATWQENLGRLDVNFENVSLIQSQVQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7N0</accession>
    <name>A0ABM0K7N0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U4/U6 small nuclear ribonucleoprotein Prp31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-processing factor 31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101862149</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110707.1">
        <property type="nucleotide sequence ID" value="XM_005110650.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862149"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="13">
        <location>
            <begin position="212"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005110707.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="54935" checksum="E92FBF861C6736A1" modified="2025-10-08" version="1">MSLADELLADLEDGGEDVGDMDEAEDGVHDVVDDVEMTIGQGASVRCVAKLRDSGELHKILANIEEYSSRPKRDAVAGPVEADPEYKLIVDANNMTVEIDNEINVIHQFVKDIYSKRFPELESLVPMPLEYICTVKELGNDILERSKNNEALQDILTSATIMVVSVTASTTQGTVLSENDLATVMEGCEMAIDLNKSKMNIFEYVESRMAFIAPNLTIIVGASTAAKIMGTAGGLTNLSKMPACNVLLLGSQKKTLSGFSSTNILPHTGFIYHCEIVQKMPPDMRRKTARAVSAKVALAARVDSFHESVDGTVGDRLRGELDHKMDKMTEPPPVKFAKPLPAPIEQSKKKRGGRRARKMKERLGLSELRKQANRMNFGQIEDDAYQDDLGFSMGTMGKSRSGKIRGPPVDAKTKARISKTLQQKLNKQNQTWGGSTTVKKQVDGTASSVAFTPLKNLEIFNPHAAETKAQQSTQRYFSSTGTFLKVSRTPMPPPSLPGPSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7V6</accession>
    <name>A0ABM0K7V6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110879.1">
        <property type="nucleotide sequence ID" value="XM_005110822.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846040"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005110879.1"/>
        </source>
    </evidence>
    <sequence length="664" mass="72705" checksum="F8E94E066996140A" modified="2025-10-08" version="1">MSTINAPHWRLQEAIREGKIKELDNLLTAGAGHANPLILFAAGNGTADCVQCLLRHGAHVNTRDASNCTALIKAAEGGKLENVEALLSAGANVALRNKRGTSALAAACYIGNAPIIQCLIEYGAKFAMSSKKNNLSPVSKAVEGGHLEVVKMLVELGASTMNWRKGSSALTLAVRRGHTEIVRYLAGVGSDLDTITRYDGPALACALRCRRTDIVEILLKAGAACRFMDKDNKTLLSIASEQGMLQICKMLIEAGENVNHSDRQGNTALILSAYSKHSQVVQLLIASGADVNAENGAGLTALICACRQSHEEIVDVLLAAGSDVNHHDNAHGDTPLTWAARTGSVSIGKLLLADGAKLEDTDKKGNTAVSEAATYNHSSFLEYLLNNGGKLDHQNANGWSPLMLSTRWNSPDTTDLLVKRGADLDLQNDQGCTVAMLALEYHKLTWFENFVDRGSDVTICDKYGNRVIEKFMRSFFRPERENSWQLLDKLLDKDPFIGPSLHLVLWKDIPCSLLIKLLKLEAYPSLQSSKHDLRSSKLGPVTPLMVALLSGHTDVARYFLLNWFLHHDDITKLPERKAVMDFLRTYYHSSAKLVSDLYDQPLTLACLSFVTVSTAVGFGQSRKNRVKKLGLPVMFQRKLLYKDDTMDCPEELWSSISLECVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7Z2</accession>
    <name>A0ABM0K7Z2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110947.1">
        <property type="nucleotide sequence ID" value="XM_005110890.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862760"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110947.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12661" checksum="4B8F2FD86B17F7E3" modified="2025-10-08" version="1">MVAQKKAKKTADNINARLALAVKSGKYVLGYRQTLKTLRAGTAKLVIIANNTPPLRKSEIEYYAMLAKTGVHHYAGNNIELGTACGKYFRCCTLSITNPGDSDIIRSMPTEQQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8I1</accession>
    <name>A0ABM0K8I1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC101861404 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6" type="primary">LOC101861404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111338.1">
        <property type="nucleotide sequence ID" value="XM_005111281.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829046.1">
        <property type="nucleotide sequence ID" value="XM_035973153.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829047.1">
        <property type="nucleotide sequence ID" value="XM_035973154.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829048.1">
        <property type="nucleotide sequence ID" value="XM_035973155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861404"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028071">
        <property type="entry name" value="Macro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14519">
        <property type="entry name" value="Macro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005111338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829048.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28415" checksum="CA5A2AC448A6E4B2" modified="2025-10-08" version="1">MAGCILNDWDVVYYLRDVKEAMVEAWQEVFDDYSESVRVSQGDLFEGAPAADAVVSTGNSFGFMDGSVDGACKEFFGAQIQRCLQKIIREDYDGELLVGQAVVMPTYGEEGKDASKKEKAIKYLISAPTVRVPADVSSTANAYLAFRAVILAVRRHNKMNGCEPIKSVLVPGLAARTGGMPELRCAWQMLQAYETFALDKHAARRRPDSLTEMSGDHLKLCQWEKQVKPSRGARIVNTLFQLFGINFSSSPKRKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9W5</accession>
    <name>A0ABM0K9W5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0669 protein C6orf120 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0669 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112421.1">
        <property type="nucleotide sequence ID" value="XM_005112364.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857299"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031420">
        <property type="entry name" value="UPF0669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31703">
        <property type="entry name" value="UPF0669 PROTEIN C6ORF120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31703:SF2">
        <property type="entry name" value="UPF0669 PROTEIN C6ORF120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17065">
        <property type="entry name" value="UPF0669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045233423" evidence="7">
        <location>
            <begin position="27"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005112421.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22761" checksum="8B06B1D9BDDBD115" modified="2025-10-08" version="1">MTSINKIIRGVLQLLICASWYKAVASKMQIQSLEDNIAAENFTYYRLHRPGTLRLELLSIVGDVDMYISTESQHPTYAHYDLKSETCGLDVISIPSSMSRPVYIGLFGHPNHLQSRCRLTIFEEEEPVVDDYQSYVDMFEKYYFDGLDESSSEQSSGRESSSKTSSKPTSKDNRQVDDELPIWWKILLGILEFGIEVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB13</accession>
    <name>A0ABM0KB13_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Voltage-dependent calcium channel type D subunit alpha-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113276.3">
        <property type="nucleotide sequence ID" value="XM_005113219.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859996"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005113276.3"/>
        </source>
    </evidence>
    <sequence length="203" mass="20246" checksum="F4635DF065C194E1" modified="2025-10-08" version="1">MASSPTGVHNDQHRPGPPQENGGGGGGGVPSRVGGGGGGQSSPSRAAGPGEDPGGGGGGGGGGGSNKPLPSGPQTNTTALASVVGGLTQIPLNTTDSGQALSSGWNTALAAAAGAATMTRKRANARKPQNQNVRPQRALFCLTLKNPIRKFCIQVAEYKAFECLVLITIFANCIALAIYIPYPKSDSNDMNAALVSTTCVCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUT8</accession>
    <name>A0ABM0ZUT8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pantetheinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934897.1">
        <property type="nucleotide sequence ID" value="XM_013079443.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848099"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07567">
        <property type="entry name" value="biotinidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012101">
        <property type="entry name" value="Biotinidase-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF27">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CN hydrolase" evidence="5">
        <location>
            <begin position="73"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012934897.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="65201" checksum="7D586A32DD89912E" modified="2025-10-08" version="1">MKCIAGVVSQRDNQTTMLAVSGQMSRIGLGLLFLCCLFLSMGDTRSLQPSQKIDGLIYSASKTYRAAVYEHDVIVPAKTNTPVTRREALENMQKNLDVYKVQAEAANEKGAQILVFPEDGLYGYEFTRDTIYPYLEAIPDPDSVTWSPCSDPERFPETQVLRWLSCLAQNNSLYLVANMGDKVSCEPDIDSKCPSDKRYQYNTAVAFGPDGKLLAKYHKYNLFYESQFNKPKPEVKYFDTPFGRFGFLICFDILFEEPAVPMVTSHGIKNIVFPTAWMDALPLLSAIGYHSSFARGFRVNVLAANIHRPAYRFQGSGLYTPEGMKEFYYNRTNTPEPRLLVADLKVLSETPSNSTSEKRHNSVRDEKCIPREFIDELSIPPHFHSEQDEQRNQRLAKIDPQHHIARTKDFFVKTARTSVSELRAKPFNNKGYTFLPLDSVFPFATTCQGQVCCYLTYELTNKSSSELFVLGAFDGVFHGKYYFQTCAVLRCPTTNHSTCGSYTFDSDTGFRRLELTAEVQTPFVLPQAVLSDGGQLQLAPADQWGFHHRMTLKFEPGLTKPLIEAAIIGRDYERDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVB8</accession>
    <name>A0ABM0ZVB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935237.1">
        <property type="nucleotide sequence ID" value="XM_013079783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011148"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935237.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="38293" checksum="421466266DA811B0" modified="2025-10-08" version="1">MGDFNGRVGERRTPWTKHLGQHSDHRTPCNYNGNHELKLCAEHDLFITNTFFQHRASQIYTWYRWNNIMVSSQIVFILTRTRMRITITDSRAIPNACLDTDHRPIITTLTTKKERKPKKHKRQQERLNIHKLGDDQVQALIRSTLNEKLGSINSTILTVEKAWDTFKTTLLDTMKEVCGTKKTRGKHRKATAWWNKEVKDAIKEKKRLYNVWVKSKNEEDYIKYRLARRHSKKVVITSKEKSWTQYGEKLSETCKTSPREFYKKSDGFGFYQGRATISCFSKELILESATIQRTGLRKLRYVIVCLFVRTSDIRQQETYSLVHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWF2</accession>
    <name>A0ABM0ZWF2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101864678</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101864678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935926.1">
        <property type="nucleotide sequence ID" value="XM_013080472.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864678"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045585902" evidence="4">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="5">
        <location>
            <begin position="64"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012935926.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20102" checksum="9247225F71EDD901" modified="2025-10-08" version="1">MQMILMIGIMFISLIGKPSAITSATAVSRVTRAQLLRAILEHSRYSHDVSKRNLERVDVTYRMDCCASETHLIHPRGGLARDGKLLEIYRDHRTVQKFYQTTCRPEILNKPCPLVDHKFQHVSRCVQKYSYVYAFVRDFNVSESFRLDYIKLKSGCSCELDFTLREDIMEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX35</accession>
    <name>A0ABM0ZX35_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ap-uch</name>
        <name evidence="11" type="synonym">UCH</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="RefSeq" id="XP_012936301.1">
        <property type="nucleotide sequence ID" value="XM_013080847.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100533253"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="6"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012936301.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25283" checksum="890618CC1FC55EE7" modified="2025-10-08" version="1">MASEQRWIPLESNPKVLNKYVHNLGMDAGWNFVDVFGLDPELLAMVPRPAAALVLLFPDDKETVNQLIGEYQSDYPDSLYYTKQTIGNACGTVAIVHALANNENVIPFDAAKHFKTFLEKTKPLNPEERAKHLEQDNLMGAAHGDCAQEGDTQAPSQDEHVKSHFVALVHCNGTLYELDGRKEAPVVHGTTSADTFLEDAAEVVKKFMARDPEDLSFNVMALVQGGDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX43</accession>
    <name>A0ABM0ZX43_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CD109 antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101850323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936322.1">
        <property type="nucleotide sequence ID" value="XM_013080868.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850323"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0882">Thioester bond</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047236657" evidence="7">
        <location>
            <begin position="20"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="8">
        <location>
            <begin position="460"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="9">
        <location>
            <begin position="744"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="10">
        <location>
            <begin position="1381"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012936322.1"/>
        </source>
    </evidence>
    <sequence length="1488" mass="165944" checksum="F6E67A4B8017E68E" modified="2025-10-08" version="1">MSVILHTVLLSALLAGVHGGSYFMTAPRSMFKGGSFNLTVDIFNEVTTEVEVAVESKIYNKRINRWETKVMTSANGTFGMNNTGMLAMGIPTEMNCTNCQLVVRGSSSYKFERSVSMYVSSVVTSVVIQTDKAMYRPGDLVRLRAFAVHANLMVYDGQFDVFITDPNGNRIQQWLAQNSTEGVVLVNFALCEETLLGMWKIHVTATGTQDTMYQTFQVKNYEMPKFEVDIDIAAYGLTSDVSLTGYVNAKYTYGEPVTGLVELHIGPNMGPNFCGNMPKTTTLSFEINGKAMFALPKVDLQRAVRLYDRTAVKVVALVTESSTGIMINATRIITFFDEEHTLRFLETTPEVFKPGLPLMLFLQVSTPDGLPPIGNTDPVYVYTVASYQFTVDDQKYYCTNEFTGMFPLTGQNLTLPDNGILPVEVDIPDNATSITVKVTFKGRSTYKTIKKTFSRSSSFLQLRLLGKYIQAGNLTSFSVSGTEDLYAITYVIVARGMIVDTGTVNGTGNRTFTFDLMITTAMAPTCRILVYYIRHDNEVVADSIAFLVEGLFENRVTVSFGVDISEPGAEVDVRMTADPNSMVNLLALDESVLHLKSGNDVTVGRIEHSLRRFDFGQRPTDAEFAVSYSAASTIEVFQKTGLLVLTDLDLYSNYHYNHDCGPPLGETQPNPYPLGKNVLESLTEEAKAEAHAKAQGKAIPEVFPGMGNLGDYNAMGPPMDILQEQAAQDFFLEVEHIKRILPEAWLWESHTVEDEGERTIQATVPKSITSWVASAFATNLKTGLGVALRHARLQVFRSFFTVLTCPSSVIRGEELVIQVTVFNYLTEPVTVNVTLTGNDMFRNIYVSKTGQQTYDSDDRVLQVTVEPDKQGLVFFPIQTVALGVISVEIQAQASVAAFTAREQIRVRPEGVPVAFNFPFLVNGLENSGGVYSNEVTLTLPESVVPGSISSRVKATGDLLGISMDSLMSLMTIPTGCGEQTVVKFAPSVYVAQYLQATGQLTDELKEHVVDILIKGYQRQLMYKRHDGSFSAFGNLDERGSTWLTAFVALTLNEASQFIYVDPTVLFKAVKWLIQRQHIDGSFDEFGTVFDRALERSKSGPALTAFVLAALEQNKDISHEEECREDRLNCQFYYRWTNATSRATRHLEHHIFLDIDRFTLSIISYALRTAGSQMAIKAHTRLMAYAVRDEKFTFWRDSGYDEGRTMLYRPNEWRPPREVGRSIDVITTSYALLDSCLENDLQLAFSVVHWLLDQRNVQGGFVSTHDTVFAMKAIASYAQKYQKPDTNMTVRFDSDKDETLEFNVTSENALTLQTKPFKEIPVTASVYATGSGLALAEIDYSFHVTQALVLPSFDVSIVCLDDDVDHFTLMICTKWLHRTDLTGMVVQEISVPSGFKAHVDSLRDVAGLKRVEKDGNLVSIYFDEITKASLCYNLQMTREGRVAKIQRNYIKTFDYYEPEYSSTVFFQPLRVAASTVCHVCKECCSLNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXT7</accession>
    <name>A0ABM0ZXT7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome-associated kinesin KIF4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101851944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936712.1">
        <property type="nucleotide sequence ID" value="XM_013081258.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851944"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="7"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="404"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="636"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012936712.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="79122" checksum="D864746A69753AEB" modified="2025-10-08" version="1">MPSESFGVKLVAKCRPLTSDEEDTGGNSVVSVSGDKVKVNCAGKESSFSFDGVFGPEKSNRHVYEQAVTPLLQKALDGNNVSILAFGATGGGKSHIMTGSEADPGVIPLMTQNLFRHIQERSNKEFMVTVSHVEILDENMTDLLNPHTRSMKIRQHPHKGIFIDGLSELVVHTGDDIALLYDQGTRARKLGSSDIKTHAARANAIFIVCVEQKERQSSKVGLRSTILLADLAGCEAQSSADPNINAGARGVLNIISALGDGKRKGGHIPYRDSKVSRVLQDSLGGNSATLIIAALSPLDKSYQDTLTCLQYCSFAKNIKNTVQLNLDDTQDVISEMRQDIARLRDKIAAAAQPERDDVAKMEALIQDLEIAKKQTWAEKEKQSAKFEDERKINLANKGILEWVMDSMKKGNREVQEQMMLLQKEKDQLTDKYKEKRKVVESMKEELQKKISEYAKFTESGKKSESETKSRVTAIHELKERLKKETEGLKQLKEQLFAVQQKQQQRREDARAHTNAVKGSAELRQKVEKEERLQMELEHKAMVEEELEKSRLELDSEKTEIQLQAAEGRKYSTKEGADLQIQVAEMKADKSVVTLKLQTLEKEKQHLASELEEVYTFHKEELEVQQLQHYQTFRSYREIFEEQKAAIDQRYRQLLEDSIQDAVYLSSRNNDLTEENQHLKHQIAQLKDVITKLGGKLPETMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXU5</accession>
    <name>A0ABM0ZXU5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multidrug resistance-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106011466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936722.1">
        <property type="nucleotide sequence ID" value="XM_013081268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011466"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="313"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012936722.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="50453" checksum="1E65DAAE59C35992" modified="2025-10-08" version="1">MALALTHALDLTRALAGQDDHRRLHPVFDDAVLAPVLWILTLILFVLLACLERSRKVVKSPVLFVFWMLGALAGLVPFFSAIMEELPESDVTGFAVVTMKYLLATGLFICYCFAEFHDHKPPGFSPEQSSSMLGWLTYLWLDKLVYKGFRWPLGDSDIFDLNTQDVVSRSIPQFLHEWDKQKLHMRRRKKPQSWRAVVKETGDVNHEKTPLLLSSNKTTSQRRAGDDTGCYGSTASPTDGTRPQMSTTYCSPEVTSAEVQVKEGADDDARTEDSGSPYDPATVKTRVSFFRVMMKCFLPDLAFTGSFQIPRLVMDIVNPFVLGLLINFTMDPSEPIWHGYVFALVLVLTRVFDTVFNMTSQFLTSRLATRIRSTAIAAVFRKALTMSSDARKASTMGEIINLMAVDSNQLQQLTRNNYWLWLSVFYFVAGSYFIYTIVGVALFAGLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYG5</accession>
    <name>A0ABM0ZYG5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106011566</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937126.1">
        <property type="nucleotide sequence ID" value="XM_013081672.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011566"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="427"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937126.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="57853" checksum="0F3FC94F4515C09C" modified="2025-10-08" version="1">MTWFRHIYPQANINSQDLSDVSACLDTGQINRKMVTGDGGALLWVSVVVSCCLSAGVTSGTKTEMTSRTGPEIGLEYRLVMIPVYKVEALGFYGLAKGWREMIKQSLVDDEEEERRGWGDGRDRGREDGGGGRDDGRGGGKDGGGGKDGGDGGGRGDGRSGGGGGDGRDGDKDGDGRDGGEKGVDGNGEGGKGRGREGERGADGGGGGDGKDDGDNGRGRSGGEEGDRGGGDGRGGKGEGRGRSERQRAREILKSLLGKRLSEKCDIEGLTNWAEWDGPLDLDIIWFTKKKVRDMMEDNDDDSGDENDWEKGPEEGRQEERDGREPRGRRRGDKDRDDEWDWKGAYYPRRGMPYRGMPMPPYPQAYPGWNPYASFWWPRDPNPFYRQYENENPKEPTEKDYVYYFLKKILSQNMKKYSERDLTNACVNGCGVDVPEGLYRSCSDCSKYWRCLDGRGTLNDCGSNLQFNHITDQCDLPSQVICSATKDIGLPASVKEGDSEDEKNGKNPKHEKKTDENKGGERKREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYM2</accession>
    <name>A0ABM0ZYM2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101860889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7. The THO subcomplex interacts with DDX39B to form the THO-DDX39B complex which multimerizes into a 28-subunit tetrameric assembly. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC3, THOC5, THOC7 and DDX39B. TREX seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with POLDIP3 and ZC3H11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937232.1">
        <property type="nucleotide sequence ID" value="XM_013081778.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860889"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="415"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="9">
        <location>
            <begin position="559"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="8">
        <location>
            <begin position="870"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1186"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="918"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1191"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1215"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1288"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1305"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1394"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1442"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1492"/>
            <end position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012937232.1"/>
        </source>
    </evidence>
    <sequence length="1539" mass="176224" checksum="DE84CDA6D6F5DB03" modified="2025-10-08" version="1">MATVCLSQEILRNWDKTGRSEFVKLCKGLTDSDSSVKLLQKKNLKRALYEVCSAVTRSQLKLENAVNVLADLKDYLPSVPSSLADILGILDVESSCSDDTSREKFLSLVNALRQVVVPDGLLKERLDQDSLELAGLVASQQGFNQKYVKTKTRLYYKQQKFNLLREESEGYSKLITELNQDITGKLTWEQVLQNIKSLIGCFDLDPNRVLDIILEAFECHPEEYKFYIPLLRAYIIDKLTLCHILGFKFHFRESTDWSTPKSLFKCAALLLNHQLVDLDDLYPYLQPLDSEIIPFHNKEVADAKAYAKKLNTVILSDKKEEDKDKDEQQIIDLRENNQKLGLCEALLEIGAWDNAKAILDRLPEHFAVVHKSISQALCALVHRVIEPLYDRNTGLTATLAKKRDKREQGQCECSRAHSFKEVFHSALPMLSYLGPHAASDPILMVKIIRLAKTFMNKRHSGGIGPEDDVAYYGFLNVLEEVLLPSLALLPGNCAMGEELWNLLKLYPYEIRYRLYGTWKNESYFQHPILIRARADCLERAKYIMKRLSKETVKPSGRQLGKLSHNNPGIVFEYVLNQIQRYDNLIGPVVDALKYLTSMSYDMLTFCIIEAIANPEKDRMKTDNMNISMWLQSLASFAGAICRKYQVELTGILQYVANQLKAGKSTDLLLLREVVQKMAGIEISEEITDDQLDAMAGGELVRQEGSNFSQVRNTKKSSTRLKDTLLEHDLALSLCLLMAQQRDSTVFAEDANKHLKLVGKLYDQCQDTLVQFGSFLSMQLSTEEFVKRLPAVDVLLSTFHIPHSAAFFLSRPLYAHAINVKYDELKKSEKAEKAKSKTKSDSKIQFYIDASEEVMHPIVEAIQPVFSSKIWDDLTPQFYITFWSLSMYDLYVPTAAYQKQIQLQQSQIKAIDDNRDMPSNKKKKEVDRCNILIDKLEDEMKKQAEHVARVKARLEEEKELWFPTGTLKSEMTTNLLQYCLFPRCCFTASDAVYCGHFIKVLHELKTPNFSTLITYDRVFNDITYTVTSCTENEAHRYGRFLCSALETIMRWHSSPAIYEEECYNFPGFLTVFRKGTDLTNKMDRLDYENYRHVCHKWHFRLTKSVITCLESKNYSQIRNSLIVLTKILPHFPRMTQIGMAIERRVDKLSKEEKDKRPDIYALAIGYSGQLKSKKVVWVQETDFHIKEPKKPASSAAQQQAQQQKQAESASSGASGKKGDGDGRAKDIKQESGGKEDKKDRGQSGDVERKEKKERGAEKKESKEKKDAKRSSGVNESNGVSAKKEVLNSPDGQHASSRQTAMEMEEDGARHPHQHREQKPVKEEKPKKSERKDREASKLAKEKAREEKRERKEREAAAAMKEEERHVMGRPLDHERDDRGGSGGHMSSSSGSSHRRSAEVSPRHVDDRESKRRRLEAGATSQDSSLEVRTKHRKSASPDDEGWEMEKEKERKEKKRDHSMEEHDAEFTKRRKSEEHYSASRKLNGEPNGSLLKGHGEREYKEKSSKQSHSSRKEQFIDGEDSPKIKTKEKREKSSSKKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYN2</accession>
    <name>A0ABM0ZYN2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC106011603</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106011603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937254.1">
        <property type="nucleotide sequence ID" value="XM_013081800.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011603"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058727">
        <property type="entry name" value="Helical_Vwde"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26129">
        <property type="entry name" value="Vwde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="952"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="376"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="918"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012937254.1"/>
        </source>
    </evidence>
    <sequence length="1023" mass="113097" checksum="68AF777350090BFF" modified="2025-10-08" version="1">MPQRPPHPNQRPPHPNQRPPHPNQRPPQMPQRPPHPNQRPPHPNQRPPQMPQRPPHPNQRPPQPAPTTPKPAPTTPKPAPTTPKPAPTTATPGPTTTTPKPTTTTPKPTTTTTTPAPTTTTPLKCPDLPPSLSLTIEADVNGNAELICAMPSAPVNNIQVEFTWQIEGVSEKWTRVIEAPDVQARLPVSELDINLFNKRIVCKAQLSWMVPGAPDCPHYKISQVLIPTLTVTTTSQLVVIEGREPEVVQVRPTCPPSALCKPEDNGRCTVQITTVITTQRREIRCSRREIKPQAVLGVTDIKTGSSSSVCGVEVTKDNWQKPVTIPVKATIDKVIDRDQTRVIQVSIRVTGKITGTTETHEIGKVPVKAIDRDRRAQCSSVNDPHMKTFDGVRYNNFVPGEFVLFKHKTLPYEVRSRYQLCSSRRPTGATCNCGAAVRSGDDVIVFDACNRNSRRVTVIDVQMYKNGQLTPGTSIRKHGCGQKYEVFLPTGMKVTISRSRQPFINIYVTPSSPDFERSEGLCGNYNGNARDDLEGERSRAPTKWNMKWKRSDTYFRGVAAYPYPSPPVYCSCQSNQSPVCKAGLDVYMCTTRRISGLDITSILIRGARRPSLSNGRNTQRRHKRAVEDDPADVEEEEDMPTMTPEEAVQNCSDYLNASPLLGKCSSYIDSNATAESIRECAEDLEALGDPTWARSHLDHMLEECMENVQLEQEEEEEENNSTTTTPSPAQSLIQNLCVDDCGDHGDCVAGVCDCKDGWTGQTCDVSAKTRPEVYPAEEICDSVTSSCSDVKIDGNNFVQSPNLSCTFRYDDTPEKKRGEADLVSMYQVICREPESELKGRKARITISNDGEEESEESYLRVVYKSSCESCQLDSDGSKKCTPKTDICIIGGECYARNQVSEKDGCYFCNPDVSTSQWDRSSDPGCGPTVCPPPEATAQPVQAGNSDSDTDTVIIVLGVLCGVMSLVAMAATYTACKGRRKPQQKHVQLEEQSPKFDIHRRNVTDPTRHTYGNNAYDNDDNVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYT7</accession>
    <name>A0ABM0ZYT7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable serine/threonine-protein kinase tsuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937338.1">
        <property type="nucleotide sequence ID" value="XM_013081884.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011625"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937338.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="51141" checksum="F2817C233F9F7B4A" modified="2025-10-08" version="1">MDVCALSYQPACFRFPFALLEHDQQHQQQQQQQQQQQQQLLQQQQQQQPPAIPPPPSQSSISAFEASSPLAASTPSFLQPPQTRNARMTQASPKSQPMGTGEVPAHYRGYVDKSTPPSYNYSPGAKRSSQSPKASPQIGRHANDNKPLLSRPMPADYKPQVPPPPVGGREAPTPPSRSSSAHHRFSYRPEYHDSTDGRSMGSPSATRGSSMLSGRYAILQFNPSGRGNSTAADISRDVKQFVSRSSDNLNQDNIGAGSKGPVPAYESDYDDQGSYRNRNSNNNNTKLGLHPSAYMQTPIPYKPASSHNEPIGVYSASLPFQAPPPPGTLAPPPPPPPPSSLRAGVDSRSVAYASGVGGGKSGGAVVVGSGGGGGGTRGGDALSGCGGALSGSGPILDTWRGKNRTPAVQQLGVKSPPPGFSPPGVASSPTKDFRHQTTDVVRKSFPAEEKERRRKEEDETYRKKRLVCPKRIIMLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZQ2</accession>
    <name>A0ABM0ZZQ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Annexin A7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937863.1">
        <property type="nucleotide sequence ID" value="XM_013082409.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011745"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937863.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11469" checksum="59518A8B987EE9C5" modified="2025-10-08" version="1">MAEKETAPPSYDQANPGQSNTGYAPPTGDPSGNPAQPDPYGYNPYPQQGGYLPQGGYPMQPAGQPYPPQYGMQGQNNTTVVTHQPMMTTQQVVHQVPDQMSLAIFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZY2</accession>
    <name>A0ABM0ZZY2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenosine receptor A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012938007.1">
        <property type="nucleotide sequence ID" value="XM_013082553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851733"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="9"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012938007.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31756" checksum="9F9434EFE430E378" modified="2025-10-08" version="1">MPPGATEWLAVSDLCSLLTMIWLSICVNPLFYQSVLPFDPRDILYLTGATPHILFAKIASLITAFITFERCLCIALPLRVKTIITPARTKVIVISIYIGMSVLMIPFYLGNRLEWVFDLTLNATVLKTTYTAEREMLEAIMFLTQGVFATAFSFIFVICCTIVLVVKLNSKTKWRQATACKSDRAVEGVGVKDQKVVKMVTFIAIIFIVCALPPTLLFFYMVIDPSFRIAGIYRNLYLVIWSSSYLTETVNSSVNIFVYLKMSSKYRAVFMKTFLNKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0P8</accession>
    <name>A0ABM1A0P8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011874</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938450.1">
        <property type="nucleotide sequence ID" value="XM_013082996.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011874"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938450.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36815" checksum="7142D3FBE77DE4D6" modified="2025-10-08" version="1">MHNCCRIPGLTLKAGGQRLPGMGEMDRHPAWKTRRANQACDRRLCLHLAALDQKRQEVETKISNDMRIMEKALSRRDQRRRHNCSLTERETIYRDSEGCEKSENNCSSTGQNSSSQKSLLLGSMDNCSGTPGQTKGNSRECPASGQRPGSVLRRPHRLTPLYGRSPFSRRRLRRLIPRACDYRTHKSSSVLCQHFPCRQPGTYHSLGFRLDDSSTDRWITWTDLKRARLSEGEVFDPKDQGRLTPGMSLKHSLPASQFLQPLDAESKEKLLREEISRRKKLNENKKPLSWETNYGEPTPFKLLRCPVRLHPMEMTTFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0Z8</accession>
    <name>A0ABM1A0Z8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012938619.1">
        <property type="nucleotide sequence ID" value="XM_013083165.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847823"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012938619.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25706" checksum="8F762E76B606DECE" modified="2025-10-08" version="1">MYKVRSKMKAATMNLRINVLGARGVGKSAIAVRYLTKRFIGEYSSGLDISYQTTYTSGDGPVKVDILDTSCQDDCQASCHDVYDADAFVVVYSVTDTDSFAEARRQLDNIRSQSQACAPVLLMGNKLDLDHARKVFPSEVEQVAEENSCQHTEVSAAECHVLIVNSLHSLIADTVSALRHRGRSVKRRRSLFENVSRKLGSVFRRKSFDDSSPTMKKKILRFAHNNRHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A168</accession>
    <name>A0ABM1A168_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">FMRFamide-activated amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100533386</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938735.1">
        <property type="nucleotide sequence ID" value="XM_013083281.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100533386"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="635"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012938735.1"/>
        </source>
    </evidence>
    <sequence length="689" mass="77717" checksum="16702C4EBD43BB2D" modified="2025-10-08" version="1">MWGRGKRQRNKNYPSGSGGGGGAFRSPAMRNDNELEGFVSILHTSGDNYVPIRDSSADHMKYTSVSAKSGMVPEHRYTMVRSRHHGRHHHHHSYQEYNTQRSAISLIAELGSESNAHGLAKIVTSRDTKRKVIWALMVIIGFTAATLQLSLLVRKYLQFQVVELSEIKDSMPVEYPSVTICNIEPISLRKIRKAYNKNESQNLKDWLNFTQTFHFKDMSFMNSIRAFYENLGSDAKKISHDLRDLLIHCRFNREECTTENFTSSFDGNYFNCFTFNGGQLRDQLQMHATGPENGLSLIISIEKDEPLPGTYGVYNFENNILHSAGVRVVVHAPGSMPSPVDHGFDIPPGYSSSVGLKALLHTRLSEPYGNCTEDSLEGIQTYRNTFFACLQLCKQRRLIRECKCKSSALPDLSVENITFCGVIPDWKDIRRNVTGEYKMNQTIPTISLACEARVQKQLNNDRSYETECGCYQPCSETSYLKSVSLSYWPLEFYQLSALERFFSQKNPTDQQHFMKIAQDFLSRLAHPQQQALARNNSHDKDILTTSYSLSEKEMAKEASDLIRQNLLRLNIYLEDLSVVEYRQLPAYGLADLFADIGGTLGLWMGISVLTIMELMELIIRLFALIFNAEREVPKAPVHSSNNGGGGGGDGQHNFANGDVEHERDTHFPDLGSSDFDFRRGGGIGAESPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3J0</accession>
    <name>A0ABM1A3J0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol polyphosphate-5-phosphatase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940100.2">
        <property type="nucleotide sequence ID" value="XM_013084646.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855116"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039737">
        <property type="entry name" value="INPP5A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12997:SF2">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE-5-PHOSPHATASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12997">
        <property type="entry name" value="TYPE I INOSITOL-1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940100.2"/>
        </source>
    </evidence>
    <sequence length="113" mass="12922" checksum="D413EA6F7A425507" modified="2025-10-08" version="1">MEGDCTKTMLITANVGSIFEEPDAMFAPWLKAFFQCIQTQKPGFVAIHCQEVGGKNYEASMQHVNQFIKTLLSCEELHKYDRARIFLDEDYTASDKFTALGNMYFIHEDVPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3Z9</accession>
    <name>A0ABM1A3Z9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pancreatic triacylglycerol lipase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106012314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940355.1">
        <property type="nucleotide sequence ID" value="XM_013084901.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012314"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047395145" evidence="5">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012940355.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15569" checksum="7292C20C3C34EB0B" modified="2025-10-08" version="1">MSRLIIVLTVSFCLLGLALSLDNFLDCPGNDNILGWLRRCCPSEDLPNSCECFDISNSSPFTNSAFHKPQCPQDINVIFRLYNPSASSGNIIKAGAASVRNSPFNPSLPTRVVAHGFTDSGEAPWMLEMKDEFLKQVSQSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4S3</accession>
    <name>A0ABM1A4S3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">RILP-like protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101848130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940830.1">
        <property type="nucleotide sequence ID" value="XM_013085376.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826957.1">
        <property type="nucleotide sequence ID" value="XM_035971064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848130"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14445">
        <property type="entry name" value="RILP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF4">
        <property type="entry name" value="RILP-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RH1" evidence="6">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="7">
        <location>
            <begin position="336"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="70"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012940830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035826957.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="53061" checksum="221B822BA1C76369" modified="2025-10-08" version="1">MDARRCLFSARIMASEEIHGISVTDVYDQAAGIAHEFDKLINAYGNDAVTELMPKVIKSLEQLETLACRYEKDVEEINQLRYKVEKLESEKTEKAQERAKFDQELESIEENWQSEVKNLLTVVSKLQEENKRMRENARSEKHAAVAEITAKRHETEEQEIKVLTKLKETVDKQREELRQMKRDLGQKAVDCDALQAQLERIAKVNADLRRKNTTHKKQARTLLEEKSDLETQLHEKDLEVDHIKKLMNEQEKYDEQRAAVKAVIDSANSVEGEDDTQVPAEADGEPMKQQLAKASAVSTGTETEPSADELPLSPGSPSSGFDLEGKVVIDLKDPNRPRFTLQELRQVLMERNELKTKLIEVEDELAHYRPREEGSAEAKDGDAEKSSYTGEEVLVYGPINKEPEEKLTGKKESGIRKLFLRILEAGFDHLVGADEIEEEEEICEVPMYGYSTSQNPKSKGMKETKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4Y2</accession>
    <name>A0ABM1A4Y2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-1,4-N-acetylgalactosaminyltransferase bre-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101851752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940915.1">
        <property type="nucleotide sequence ID" value="XM_013085461.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851752"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="11">
        <location>
            <begin position="115"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012940915.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28014" checksum="F3D2AD11B9EF00A6" modified="2025-10-08" version="1">MPGNCRSAQRVAVVLPYREAQAQLRVVLHNLLTVLHAQMLDFTVFVIEQERPSQYNRALLFNVGFLEASVLRDYDCFLFHDLDLVMVDDRVTLTCGTGPRHLTLEPGLRPGYGPENANMFAGVALFTRDQYIRINGASNLFFGIDGGEDDLWRRVHHSNMMMSRVAGSVVAYSQVRHSEQLEEDKDKVARKLRKELLRRSAERIPEDGLTSLTYSKLSHAYTQLAIWIKVAVDQNLIQQVRGVSSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5L5</accession>
    <name>A0ABM1A5L5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101855964</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941275.1">
        <property type="nucleotide sequence ID" value="XM_013085821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855964"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941275.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="72320" checksum="25845899FF49077F" modified="2025-10-08" version="1">MMVFNLDCGVGYHKSLSFASSDYPVPEIVNCPSGSKVNGDYIMSGSTATCECRQKTEGFPAGTVVLSQGRSTLGSGTVASGNVINPGNINNDQTLTCRSESSLGQAGPSVSETVMFAYGPSSATLTFSPTSPSSLCQGTSLSIAYSCAVDPRTVNPQAVYKISVNGTQVGTSVQQTLQLQGGAHNVRCLVENSLFPADLFTDVTETFTVLVPPPDPPEISMSKSSVLSTGETLVKENVTTSVQCVVRGGYPATSDVRLSCPSSQAGSSGVSSVVVTRSKETQCSCTATHDSGCYNKRSDVTIRAAYGPADLKLERKNVGPEEAGTYNLCPSATPDITMECSVGVVYPAASLTLTMRPKGTLNVFYCTRNNKCSTEFVPSRGGNHEFMCYSVNSAFADMAGDSPPVQVYVREPPKDAPKLTLNGKDFTGATAENVVVFVDGQENSVVCQVEGGFPEISPSDIYVQCDSENVTDGKVVFTPDRNTTNCICRAQHPSGCYDLSTEVLVIVILQNETKLQQSDDQMTILIAVGAAGAAFVICCVTTAVVYCYLKRKGCFRRMAKHKEKQLRSEKTQDNDGTRGENQYEEIDLDKVSIQDIHLPALVGKSLPKTTKPVCRREENAYVDIDADNLSSQDISTPVLVGKSSSGKTKPISRQEESPYVDVDLEHISSQDIQTPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A739</accession>
    <name>A0ABM1A739_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LOW QUALITY PROTEIN: pikachurin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942142.1">
        <property type="nucleotide sequence ID" value="XM_013086688.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857588"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045626329" evidence="5">
        <location>
            <begin position="30"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="276"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="456"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="498"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="674"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="716"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="870"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012942142.1"/>
        </source>
    </evidence>
    <sequence length="903" mass="98516" checksum="C27DCFECEC382371" modified="2025-10-08" version="1">MAATSCLSFRTVVAWTIVLNCFLMVSVSASQRGKVMAFFQKTCDTSRPNPCQQVCQDIDSGGFYCKCDPGFTINSDGMTCSKLPAPNDASTGTHQSLEPLENESDPPVPGPKVVGSGPAAPKVKVNQDGEVMISDKDVVHVETVDLTKGLEPPRASEQRRPHHKTQSSLILDRGYYDVLEGGGGVASPNDVNFNPLDIPEGGSLEEEEAEKELLRTNQIGVPSIQEEFRPRFDGQVVSCDGVVCENNGTCAVMQGEAICRCPLGTLGTYCERVLEVRYPKFMGTGFLALPTLRNAHKEFRVALEFMPESLNGLLLFSGEMSDARTDFFSLVLDDGYVVYKFDCGTGAAELRTPNRVTLGAWNRVEMSRVDNHGSVQLNSHQEVEGSAQGDYTRITFRLNMYVGGFSDMASIAGRVGTDYTFVGCVQELSINGHLYDFRQKGLVGEAEFGVNVGECSEGVCDGVTCLHGGSCTASSADRHVCLCPLGHHGDSCEKSSPVHVPHFSGHSYLEFPGLQRSVLSFTELEVVFKPTSPDGSVLYNGYSRDRKGDFISLAMSEGHLEFRFDLGTGPAVIRSYEPLSLNQWHLVRASRTGLMGTLDIDGQRQTNGXRQGAYTQLTLLDGLYLGGHPNYDHTSRHANLTRSFTGCLQKVVVNKRTISLLGNAVAGVNVGPCSHPCAGQPCLNGGECKPVRDAYTCYCPIGYSNTNCEDEQAQLPNKPMFSGQSFLQYRDKEITKRVTGDRMDLQIHLRPRGPDGLVFWSGEDLSGPTGRDFMALAFQGGSLQLRYNLGSGEAMIGYNDSRLFDGGWHFVRVQRDKQDSYMEIDGKEIVEGSSPGGYTSLNTNKVVYLGGMPNIMEATGGRFMTGFVGCIKGLKLATDYDVKLLGHAYRGRNVVQCKKKMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7J0</accession>
    <name>A0ABM1A7J0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Craniofacial development protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942356.1">
        <property type="nucleotide sequence ID" value="XM_013086902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012817"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF67">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012942356.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="43000" checksum="6149DD0C10EC11F5" modified="2025-10-08" version="1">MTQNKISIMGITDIRKKGTGTKEIHSNFVLIWSGVRKEQRAEHGVSFIIHPDKAKEILNTDFVSERLIKISIREGKKTTNYIQVYAPCNDSYSDEEKDSFFGQLSDLISNIPDEEDLYVMGDFNGRVGERRTPWTKHLGRHSDHRTPCNYNGNHVLELCVEHDLFITNTFFQHRASQIYTWYRWNNIMVSSQIDFILTRTRMRITITDSRAIPNAGLDTDHRPVITTLTTKKERKPKKHKRQHERLNMHKLGDDQVQAQIRSTLNEKLGSINSTILTVEEAWDTFKTTLLDTMKEVCGTKKTRGKHRKATAWWNEEVKDAIKEKKRLYNVWIRSKNEEDYIKYRLARRHSKKVVITSKKSHGPSMAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7P9</accession>
    <name>A0ABM1A7P9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012844</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942452.2">
        <property type="nucleotide sequence ID" value="XM_013086998.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012844"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942452.2"/>
        </source>
    </evidence>
    <sequence length="158" mass="18380" checksum="F706CF656CC6EDCC" modified="2025-10-08" version="1">MAVRSGTISWPKTRMWTELDVANFVSETGFPHYALGFRQNCVNGQRLEEMDPFDFQRVGVSNIGDAIGLHAAVQREVNGRLINWDDPNRPLNLGDVRRKQWSLPPLAPPPHMKADDMVLPLRDRGDRLYRYQQPTQSYHDHCMVIGRIDDWKRYNSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8U2</accession>
    <name>A0ABM1A8U2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106013012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943041.1">
        <property type="nucleotide sequence ID" value="XM_013087587.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013012"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012943041.1"/>
        </source>
    </evidence>
    <sequence length="659" mass="73949" checksum="BA676DB57CB16B5A" modified="2025-10-08" version="1">MTFRTEVKQEPHTEGDSNTDVMKTEKSEVIETAQRHSPAPPSTHDGTTTRHRFRLLSNASPLRKNSFPSQLQPSSGLCNDEDKMAVQLDRMNSKYLDSPAADSNSVLPNAFNCHCSHTTLSSLKSRHHSSSPIEQAITPQNGVTSSSALAHCAETDEFCWANSSKDVTDFSIEEILKPSFGAKKQPEPSSIERVVTSISQPLDIRKQKKNTPQKSRPSLSISQSDLDGRKRKIPTAHRRSESPEDSKRDLCLFLFQKTQEISGSTRPETNISEHKKHNAITERSCNDVMEKSALSKDNISETSYMNFLYNQLIPNPICDANSQSLKAHLHSYLYGLGSNIFGYQSLQSLVASSRTYFSSHLPQKYPLQEQDLFSNSKTKNHIPFVELGMQHEYQMMGHFYEAKETPAGVNEVGEIQRSWRGQNHFDDVDENATETTSHFESESFDGLKMKKLCVDFINTERKIDIECDAGDGCIVNRMEYSNNNTNNNNSNDCKTHSNYNTSKKSSSSCNNNRNNNNNNKSNDNLESSNIKAGDHKPHTSKNGGNATSPQTLVPSVSDMTNTEMTTSSLSVKTSPTSTSHQCGGVKDELPTRSPNAEVKDKNRSRVFPLPAWVYCTRYSDRPSSGPRYRKPRHKAHSENDKRPRTAFSTNQLNRLKIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAV8</accession>
    <name>A0ABM1AAV8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944188.1">
        <property type="nucleotide sequence ID" value="XM_013088734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862379"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029512">
        <property type="entry name" value="CCDC154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35153">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35153:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15450">
        <property type="entry name" value="CCDC154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75708">
        <property type="entry name" value="Chemotaxis phosphatase CheZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944188.1"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111927" checksum="DFA8A6E7BAE8040C" modified="2025-10-08" version="1">MQAISLKLNEMQRNRELLEKQTFNLTEELRGVRSKVESQAMELTTTINDLKLRSRRLEEENKIQLDALRKQGDLFSSTETSTTHLRGQVETRLAELRDVVLELRNKQDQEANDRRALEQQLQQKVNQLQQNLGEQNRKREEAMHAMDMIHREKEHSAENEKLRLQGKLTETVEEVNKRLLTKEIKLREELQEKFNHLEKMVQQEQQVRQKHEATIREENEKWRQGLKKVSDEEMYTVRDTFQSERQKSKEAVQKLDESIGLIEKQLAENKRQSDKVVAAEIKSRKQHEKATSEKLDHLNEKLSLATASLQTAMGGITGNLTNHTDKLRGEMKSMLASSEQAGTRTMTDMDARMQSLKQKVNNLEQQLDGRISETMGLMTYPEALEFSEATAILAQNLREKVESISLWQDVTSQTIRELNQSIQGLPNDIYALEEKQKLLKSEVDSRLTTETDARIRDVEALKHEVSMLRNKRQPQFATAEEMQELQISVRKLAESVQSVKTVIGMKLQSEQKLRLSGIEDLQIQVNRLKSQVGMHSGMHSTMPLYARPDTDPNFMDDFMAHDITQDIPYGRSSFRLPDTRADLDSAEPVHDGYAAKYSKKSAGPAGGDGSVGGYGKGTGRPLDTVSEGGDSQAGQADWNLLSSLAYGSYDEKGQGQKGGGGGVGDKDNDDEGGWGGGGGGVGAVGDKKEGDFPNPRKKDDDGDGGGDYAKEGERGGESRLRRTPPNPRDGGLSPAVERTPSGARTFSPHDRATEASFKGARPPQPDSEMSAELDSVRENERRPESMTEAPSQVSGKNTPMNNSGVPNSRKNSLAKNAADQTSRNNSPTKSVQRMSRKNSLAENGDHASQRNTPAADKTGQNSRKNSPVKSVSRMSRKNSQAENDGGQNMSRRTSPTEKTDENKGGEKSPMKNTLDWEPASPGPNARDTAGAKDSARDQDKPMSNRLAWEPATPTPRNDGVADPSEVKGHWGQESVDETDSEDHTSGNNNSHNNNNDMASAEQVLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB65</accession>
    <name>A0ABM1AB65_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106013370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944357.1">
        <property type="nucleotide sequence ID" value="XM_013088903.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013370"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045625833" evidence="2">
        <location>
            <begin position="28"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944357.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21150" checksum="686A5A55B8DF9C7A" modified="2025-10-08" version="1">MQCEVCARHSFCLLVIYCLYFIFRAHSAPISSEAPGLHPRSMNSAVIAMGCNVTTSYVRHHYFQLEPIIGKRDADSRDRQETAESPKNTSDKALTSAVIKQTRMTTFQNWNSSGSLMDDLQMWIHHVSWTHMVPLELVRGLKNCGVAYCLEAFNASTDVRKLFKSLSGPVPLSDQSKTRQSTDHPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABD8</accession>
    <name>A0ABM1ABD8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosome-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944459.1">
        <property type="nucleotide sequence ID" value="XM_013089005.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854367"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16470">
        <property type="entry name" value="RING-H2_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23818">
        <property type="entry name" value="RWD_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039133">
        <property type="entry name" value="RNF25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198">
        <property type="entry name" value="RING FINGER PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1056"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1157"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1538"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="692"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="754"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="904"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="942"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1080"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1128"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1157"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1269"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1550"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1574"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1599"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1640"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1656"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1724"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1740"/>
            <end position="1754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012944459.1"/>
        </source>
    </evidence>
    <sequence length="1834" mass="197122" checksum="6072175C0B9E1483" modified="2025-10-08" version="1">MDDSDSEFQSELETELESLQAIFIDELTFSRKEDGSVDEIELLLHPSTGHDTSKQFVCMRLVFRPPTQYPHEAPELEIRNPRGLGEEEIESLAQDMKVKATEYLGEPMLYTLIEMARDSLTEGNVPRCPCVVCLEHFEPTDAFQRTGCYHYFHTRCLHMYLVHTRAAMAEERRTREEEGAKHVREQEKEEVIVCPLCREPLDAESLSVVCESNETVEEETFVPSSELRDQQRRMAEVYQRQKAKGGIIDLEAERNKYLVNPDTVVTIPTSSTLTADAPASRQKSPRNERNNSHGVGEKATSRQTDRNRKHEGLGEGHRRAEPHSAGGRGRGRGGQGRNSEGDGDRSSGKTRGRGRGNQEEFRKNRSQGERGVARGGGESRGQHRDGEDEREVERKMEDGRKNERKVEERRKNERKEGEGEETFSRGHNTAADEGRRAGGNSRARSRGEVETMQDFGEDRPRQDGYRDGGGRGQGRVRGRRGRGGHSSRGGGGSEVTDGERGDVVSVRVGDGSRRVNEGEGVERDGQRRGEGSRSGQGRGAGGGQRYGEKDGRSADVTKTDGSLGGRELGDGVRMAGGFGRDGRGRGGKSSNSEAAASSARGGSVLSGSDSSAGERDGDRSVSSQGDEGRPISSRGDGTRSRGGARGSDRWGYERGGQGKGWGGRGGRWDNDRDEHHGGRSHKGGEGQERSRGQQQQWQNRDGAQSGRRSNNNNSSNSNNNMGPGGPNNMRPRMMGNGGVPPNSMGMGPGGMNQGMGPNNMGQGMGPMNQNMGPGNMNQGMGPGNVNQGLGAGGLNQNMGPGGPNQNMGPGGMNQNMGPGNMNRNMGPGGMNQNMAPGGMNQGMGPAGMNQNVGPGGMNQNMVPGSTILPPSEPGSATATSTNNSMGGPRPPPVSAGQEVGFMDMDYRIKPDFDGDGRVEQRMNTGETNEMGDTDHRVKEKEVTEEDEDDEENSKDLKELDKIRQQIQAQIDNASDGEEEEEEEGENEDEEMAEDGSVLPKKEELSPERMDESGQEIKDEKAAIKAEVEAEMANIEVPAHLPKKQRELFIRIQQQQLMREKEKEKQEAAKAAEDSEVKEEAADDWYSSDEEGDNQKAPNLTDVLKKLSKDTLPVSSSEGSVVKQEVPDTSSASAAPATTSTGSMFNIMQMINAIKKQSSTSSAKLPTETITSTQAPGSPKSPTDSEGKPFQLPSALLQQLPALTVDPPVVSARPLNPLKYAVVKIALNMPKPYTQLPKGVNASDPSYKSDPRVKWYLQYLEKQLQSAPKEVVRRPSVDTEKPSKPVDPRLKKVPTDPRLAKAAADSGSGDVSRPTDPRLQRAQAQGRPTDPRLARQAGANLDPRLNRQNSQDPMGNMGMMSGQMSSPMAGSGGVMNTGGMGMGGPMNNMNSMGNMMGGMPNSMAGGMNSGMNNMGRPMNNQMGGPMNNPMGGPGMMGGPGPMNNPMGGPGPMNNQRGSPAMNNQMGGPAMNNPMGGGSMNNMMGGGPMNVMKSRMNNPMRPFQGGPVNAPMGGPMGNNMNRMGNPMNPMGGPMNAMGGPIGGNQNMNRMGGPQGPGGGMGGPGPVGPQGIMGSDSGDRRMAGDFHNPSDPRLGGGQRPPNDPRVKIKASEPNKNDPRTNRRDPRMGPVSMDESDSDIRMLSSDPSSGSKSNNLQRPGGSFSNSSKDFSQSGNFPPPPLPDPMMDLPIGDADLRLGLGTPPTSSSSSTPPPDSMQDFDSDLPKPAQKFDHRNDPRFKRVKRSTSQLKNSVEYNSPLGSAEEVMVSEEGDGSQFSNYNKPRFPPGKDPRSRNVPSPSLPDTLHDFEAQGPPPPMEAEPALKVKDLFKTIDPTASPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC64</accession>
    <name>A0ABM1AC64_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101853652 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944909.2">
        <property type="nucleotide sequence ID" value="XM_013089455.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853652"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="108"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="224"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944909.2"/>
        </source>
    </evidence>
    <sequence length="376" mass="41915" checksum="DBBEFD2A045ABCF7" modified="2025-10-08" version="1">MRARYEYTPIQLFRPPPRIRKELVVSKENTPLVKPPQTDTRSRGSRSVTVNCCRDSGYNSAGDRDTERTARNILLRRSGSPASVLGIFLVTLMMMQIVQVAPQGPPYPEPVFLPRLLNVTAREGGTALLPCAVHFLGTKEVTWKKLGGDHFLSVGAITWVKDPNLELSFNEITPEVTEWNLLIKRVAPEHAGTYECRISDKDKLYRYIKLNVIGPPLEEPVSRPPIALSGKRYVEQGEPIHLFCNTTGPLGDHLSIDWFKDGDKIDYSTYKHIVITNYNVVETNSLFRRPNSSLLVSELLIDRSRASDTGTYICRSAQGYIANHKVTVLFADTTNVKRGNPSTGSGTSQLQCLDILIHVIIISVISLQISLIVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACC8</accession>
    <name>A0ABM1ACC8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-methylmethionine--homocysteine S-methyltransferase BHMT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945010.1">
        <property type="nucleotide sequence ID" value="XM_013089556.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848928"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012945010.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39115" checksum="B81929053DE970C3" modified="2025-10-08" version="1">MPRVKGLRERLRDNENIICAEGYMRELERRGYVQYGPNTPEVVLEYPDQVRSLHQEFVLAGSDVVEAFTYYGHRAKMRLIGRESDLERLNRSALRIAREVADQTGTLMAGNICNTCVYDPKDKSTFGPVKKMFEEQIRWAVGEGADYIIAETFSDFGEAKLALEAIQEVGKGLPAVVTLTAYCPDVTTDDIPIEEALRQLEILGADVVGLNCGRGPETMMPLLKKARKICKGPLAALPVPFRTSDKEITFQALKDPVSGAPAHPLDIDCCRCSRSDVRRFAKEARALGVQYVGLCCGSSSNMLREVAQEYGRTPAAGVYAPDMDKCTLAQARTAHVQKRQFFAYSRVYNIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADG0</accession>
    <name>A0ABM1ADG0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cylicin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945578.1">
        <property type="nucleotide sequence ID" value="XM_013090124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013700"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945578.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19337" checksum="A385556A2E4E243B" modified="2025-10-08" version="1">MATPYYSVTSEGGTRYVRRKHRRPDGTYSDSESCPSDVDVEAATARAAKQGKGGKKGKKSISEGKEKEKGKRKDSEKEKKSKGKGGKKGGEDSEDENKKRKGKADRQKGEDADDEDSDYSLKSVVSEGGTRRKMKMKRIRDEDGNVVGYGDAIPADVRASSVTGRRGNRLVRLFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE73</accession>
    <name>A0ABM1AE73_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Troponin C, skeletal muscle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945985.1">
        <property type="nucleotide sequence ID" value="XM_013090531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850693"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042847">
        <property type="entry name" value="EFC12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47225">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47225:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945985.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22497" checksum="5E32855A4FC81B8B" modified="2025-10-08" version="1">MLTSIDRNEASGVKLLNLGNTKVFAKFKTLQDKLEEERDLKVLHGGVLDEVKKEVVEIDPMEAFLRDPFTKLKEWVARAGYRLIDLLRHFDKDQSMTISIEEFREGIEATSIPITEEQIQILVARLDQDGDGEIDFRLVLSRGGLRVFFKILHVKMKNNKDIHMFTKFPSSILSICIPSDYNCSILSQSQLHCQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEQ4</accession>
    <name>A0ABM1AEQ4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101849820</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012946261.1">
        <property type="nucleotide sequence ID" value="XM_013090807.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849820"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20338">
        <property type="entry name" value="BRcat_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20355">
        <property type="entry name" value="Rcat_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="151"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="155"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="646"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="830"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="913"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1154"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="943"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="966"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1110"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1190"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1204"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012946261.1"/>
        </source>
    </evidence>
    <sequence length="1215" mass="127420" checksum="E4AC370AA6547B10" modified="2025-10-08" version="1">MFSSLRASSKKRDSDGISASSGASRSSDAKGRTTSFSLSRLLPLRRRSKSRTSLDSELSRSDNGGVCSGLGSSPFPGGGAASRNSPPLPLSSVVYLSHSYSSMGAQGGREQGEGQTNSDGVLSSPADVPKDGPSESASSELAPSSVDRKVEMIECPVCLMEKAKSCFLEISTCHHRCCSKCLKEYFKIEIMESRVAIACPECSELFHPNDIEAIVQDAGLMHKYQDFMLRRVLAMDSDTRWCPAPDCGYAVIATGCAGCPKLKCERVGCDTYFCYHCKQYWHPNQTCDAARAERSPNIRSASVSYSQESGHQNEIKSCPRCGAFIVKMDDGSCNHMTCAVCGAGFCWLCMQEISDLHYLSPSGCTFWGRKPWSRKKKILWQLGTLVGAPVGITLVAGIAVPAMIIGIPVWVGRKIHFRYDKASRHKRNLAITGGVAASILAAPVVAGLAVGIGVPILLAYVYGVVPISLCRSGGCGVTTTNTGGVRFDFDEENENNTQGPYSLAGDNHSLETAPNVANPSIAPSIGDASLGMTNSLSASGSHMERAGVLRDDSDRDSSSHRAIAGNSINGSLCSATYSAQHHKLEVRADVSEHTGQCERSSVGGESYNVSLTDDASTRALAGSIISPKDKDGISLCSRHFEAPLVYPEESGKEGEGEAYGGSGGGRGSSSCPTSPHLRKASPAPSEEARSGRSKKCTRFMDQVSEIESRGDCVSLGSVLSTHSESSSSGGSPSCEGVVATVTVTSSVVGGGGACSSLSLAVSPSEEDEEKEEIGGGAAAALASCESLLSEGRAANGAIRRTTSLGNGCGVKAESTSVLLDGADSRRCEMGGARRKSERMYRDELSSVGRPFMGPHKKGGGPRDKEHRSQPGNLSDISEMKGMPALHTAACSDLLAVVDASCDNVFLDRPAHTTARIPSSSSSSSSSSSDQPTDSHPHGVQRRASSPGEPTSASSSREPLYPALTRPDSHSNDGHTCTRDDAFVSASSCDVSVSDMKIDLLDGPDGHLSPPPAPEAASVLATSSEDNTGPCGAEVTAGEFVGGASVRLCQLSALVHEASAAGPTDTAQAGARDWCFSRRTNIGQVSARPAVPDVERPVSQPGPVAVETDASRVTSAPTPSDRPGSQNCVGRSNSLNASTVAAKRTNCRTNCHSRPPCQHPHTDPHTAPHTATHTDPHTDPHISLPVAQGLPPTTHTTNISFSPSDQEHWPSDTEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF24</accession>
    <name>A0ABM1AF24_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">A disintegrin and metalloproteinase with thrombospondin motifs 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101847859</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946441.1">
        <property type="nucleotide sequence ID" value="XM_013090987.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847859"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF311">
        <property type="entry name" value="ADAM CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="14">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="15">
        <location>
            <begin position="666"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012946441.1"/>
        </source>
    </evidence>
    <sequence length="713" mass="80563" checksum="878C11B47A1D80DD" modified="2025-10-08" version="1">MHHDGAGNQCGMPGKEPARLMAARLTKDTSPFHWSSCSRKYVTDFLDEGKGWCLENIPLKRKGYPRDLPGDAYDINAQCRLQFGPKSRACKLKHACKELWCMNEGDSCVTNSIPAAEGTECHISRQKKGWCFRGECRNPKYEPKTVHGNWGQWQGWGACSRTCEGGVSASERECDNPEPKDGGRYCIGQRKRYKSCNVKPCPEDAIDFRQEQCSSYDGVAFRGRKYKWVPYSGEQAKPCSLVCMAEGYNFYTERSKKVKDGTKCFPDQPHVCINGDCHFVGCDGYLGSRVEEDNCRVCAGDNSTCKTISGLFDKPLPKGAYQEIVRIPRGAMYVNITEAKYSRNYLALKDGQNKYFINGEWTIDWPRKFPIAGTVFHYKLTEHEPESLQALGPTSEDLVIMMLLQEDNRGIIYKYNLPVNKSAEKHDISLYTWTHSAWSPCSKSCSKGVSTSKAQCVLKSDGRIVDDHYCDRQPKPSDHSKSCNKEPCPPKWSIGQWSDCSQTCGEGGHRTRLVVCRQLIGDNEQLVLDDSECPEPKLPSERECRLEECPPEWHTFEWSECVPSCGPGEKSRRVFCMSSDASTYLDERRCQAGDKPATRMACINRKCPPPQWRKGEWSDCSVSCGEGIQERSVQCQSFNSEPCDPALKPKAQQKCRSSCERNVNSSFANCEDKFRVAYCPLVLKFGYCERTYFQTMCCETCTRAGAIPLQRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFM6</accession>
    <name>A0ABM1AFM6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho GTPase-activating protein 19 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946706.1">
        <property type="nucleotide sequence ID" value="XM_013091252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858242"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="91"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012946706.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="75827" checksum="4203D3D337E91ECD" modified="2025-10-08" version="1">MDDTFSERMDPLTPLSQQRVEEDRSVSRMQRLYPEKLRDLCSMHLAFILDLSDTKLEDILSDMVPSTQKKKLGLTPLFKKKEKTPQSVFGAPLTENGVSLMMPLIAHLQNPESLKEGLFRKPGNGRKMKMLKEQLLTKGGDALIDPELFGPHDVACVLKEFLRELPEPLLTNKHIEAYRQIRGLGAHADTAEEKGWYAQRKLSAVQLLIRLAPTPVQKMVRYLMKLLLKVAQEPETKMTPTTLGTIFAPICFLNRKATASDMCVLITETEPSVAFLIENAKELFEVPNGLVRDVMSFWTDVVKCQPEDSSEHPKMKKFTSGPIVNTNICYIDRKASQCEDVATNTQAELASLYAHVQSLPDTPHNVKLKKQIQKGTTTPVSSSKKHPRSKSIGASIKKRLPNLGSTKNKNTEFSVLGSASSSASSEDSLGVYVMSYKSNDQVAVVHCAELDLRAVKIPLVKRLDFSNMQDTVITPAMSNLLNSPTTTKIRGALRESRPRQKRSHTQCGQGTSDCTPPKLECRPKSMDAMALSPKENIPPPVLTSSTHKDSSRMVLKPRASALPSCNSDTQAAAMLQDINDKSAPEKAQAVLRKEGPKRADYCDIHLPISATTLCISQSQMAVAEKEISYLPYQAPSGVIRLQTPERENARAVNDAPLRKCNGAGTPIVRRTLLQLSVSSNFETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQV7</accession>
    <name>A0ABM1VQV7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Gamma-butyrobetaine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101863254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824799.1">
        <property type="nucleotide sequence ID" value="XM_035968906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863254"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="10">
        <location>
            <begin position="85"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="9">
        <location>
            <begin position="193"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824799.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53293" checksum="E80FC471F3239A37" modified="2025-10-08" version="1">MARRQLISKCLAAACINRPLCVQVQTSSRNVTGKRGVAVKSPGFGHPPPLLLHIPPLVTRPQLQHFSTASHAIGDSSPMLDSTTLSHNGKTCLLRWQDGFQSEFHSVWLRHSCHCPLCRHDNGQRLLDPATIQASCTMERIQQTGSYLEILWRQNGEYHSGHVPIEFLRDHNYNEETMLATRKRVKCAKSVTEIPTVQYDEIRSSQKGLLKWLQQINEAGLSIVKGVPTEDSMVLEVAELIAPVSKGIYGYTFDVEAMPDAINVAYTNVHLDLHMDLVYFESPPGLQLLHCLKFDQQVEGGESVFLDVFSIVDEFRAEYPHLFDTLTKVPATFQKVHYDRDYPVHIVNQKPHIKLNHLGEVIAVYWAPPFEGPLAVAAEDVENYYRAYEMFAKALAESAHMLRYRLQPGDLVIFNNLRILHGRDHFTLNGGMRHLKGCYLNIDLFKSKTQVLSKLVGDGRPAKRVGNQCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQY1</accession>
    <name>A0ABM1VQY1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Serine-rich adhesin for platelets</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC101846640</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936205.1">
        <property type="nucleotide sequence ID" value="XM_013080751.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824823.1">
        <property type="nucleotide sequence ID" value="XM_035968930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846640"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF15">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="953"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1220"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1258"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1468"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1512"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1575"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1827"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="979"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1278"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1468"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1904"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1959"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1976"/>
            <end position="1985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012936205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035824823.1"/>
        </source>
    </evidence>
    <sequence length="2346" mass="250401" checksum="20E35CE572653612" modified="2025-10-08" version="1">MAPSRKRASEQGVDKGQESSPSAGQKCTFSGCCGQGHINDKFSSHKTLATCPLAAAKKLKQEEPSLSKRSKIEKRSATSSSLGRSEHSDTSRSSRSSSSAKSTSVVEAEGKPSGGSSTRASSLRKEVPQNAGPATPVGAGGKKNLARRELVLDDVADSPPRASRRSATRTSEVAVISGHTSRGDSKERQSGGEKEDQIGTGKSPRRQGSGSADSRSPSSATDRNESKSSVANSSARGKLRSTSSTLSAREASGDVKILKVSPKPEQKETGNKKPSVAKTRNESPEEDNAKPSPRSSRSGTRAEPMTTKMSPAETRGRREGKDSPIRASTRSSNTESNPRDKEGCAKVGGAATSKSPVRAATRSSSSEASSKDKDVCGKQEGIVSKSPVRVVKDANPSSAGQKKEEKDKQGDTVSSSYRGTRAQARKDADLDKKNTIAAITTTSPKPSGSPKACANAKAIGVPKATSSSRVVGAKASPSSKQDTVVERVVKEPAEPVSQKRTREEEETGESTRKKRKSDRFSVQTAVDRLRDEQVQVATSSKTNAPEEDEHSLKDDDNVVELKIESTEDTADNADEEKIDNIDSKSLEIETKKWINKNKKDGSEVKTESVEDAISNDVETKTNRMGIKTEDDIKIIEVKTDSMDNDTDGADIVQVDPLSSGSMLEVRDLTSNESHELHTAGQTKARDQLAQVVEENMLLYRTGSEALNVATAGVSAGGEDEVQGEALTGTLDCQSKEGSCGPLAVDAEVEEVMDVGDEGVPGDLIGTDDDEMMNKGSTDVIVEGRSIETVMQDGCTKDSFCTPNGLSKPGGKVEETSMHDVCRDGGGTFTEQCKQEGDATVTESGAVKEELVLFEDKPVMPVSATETMDQSKAPAAHEIDHRNVGHQGATGEGGALLALDELEEKAAQVCFSVGSEKLSECGVVDSMLTSGGEVAASEDMVGCPLAGAALECPVEPSETGERHQSPSDTQECMGSCETDQSERVTHEKLKSPHEEETEACDAEREVSGREDKFEPDTTKNVTQETQQKDKEEDKGGDSELWKKIEIKEELLDLKEDMKKEVDSELCEEVLEKSYVPKLLVQQNIEKIAFASMEDTERALMKHAGHASNFETNVEVKEEPEDLQEGEVSSLDPRPHSPVPDLVEVKEEADDFEVVAEWSTWPMLSSGDTFCNAEEDFVAGLVASTGDSSCGQGEPNVAQASVKTGDVEASDVCMSAAVASPQSNSCGKVRPSEEQPSVKTSCEKETILLSMSPMVSSLQSVSSVTDSAGEAGSVPSSAHLSRETAGEHGPGRFHTVRDTKSAPPLPVEGSSNVQGQLYRDMNPKRTVSILVQDPDPNPEATSLLQVRMACGETAIINVKKTPATENVDASPDIILLSGNPSGLVEGSMTSEMAAAMSLVSDKIRSNKKVSLLKPFLDQQRCSSAPIICSVADFHPKATCRQEPTVKTESEYVPRDLCILPRRAPRLVNCNPQGTKPMVNSNPQRTKPRVKHRAPEVSYLLTKERGGRIVKEKDTMTEEVTAGEERTQTLPPSVSSLKSSDSDLIEVISTGSQKFMTPSQDLTVTKSSSASALMAQTESSSVSAKMAPTESSSVSAQMAPTESSSVSALMAQTESSSASTLMAQAESSSGPPTEVILTKYSPEDLAEMEYEMKDKHIMGPKACPVPACDGIGHVTGLYTHHRSLSGCPNRANMPSNLFEKLLKKEMNLRCPTPGCNGRGHINNNRSTHRSLSGCPLAAMTKLMNQQPQSGSKSAMHVVVLPKSDDPTKAMIATCSEKDLIKLVAKEITPGTDRVLRPMILTKQFEPRESNAVAQATPRENLARELEKYSRPEMVQGSSTIEVKFEPKSGASSSRSTLADEVVVTAKSMAQMKHAPERPNILSRRPHMRHRPGLLNRSRSTGNKILDAANSLRSSSPSSVSSASSSLSSPSSSAPRAHSKPSSLLAGNGSEEDSDEEIRDNMSSASEEPPSLLPSRSPSPEFPDAPSPLPLASSSGKDPFLELMSSRLSARHRSEVTCPTPGCDGSGHVTGNYSSHRSLSGCPLADRATVQAHQVEQKCPTPGCDGSGHVTGNYASHRSLSGCPQAARMKKILMKEGEKKESEDPLRCPIAGCDGSGHVTGKYLSHRSASGCPVANKQRGGHKGLLAGLDNGHTETLPWDTKAENINCPIMGCDGSGHANGSFHSHRSVSGCPRASAAMKRAQLSPKELMVLQMKAQAGEDLEDDAELRRLDEEIAELKASNAALEARVSARRTQVSSRELALIQAAQETEVTETCVTRLREKLTTVQGDLIAALTPILAQHASDLDLCGPLTCDNLYEVIGRLQSLSDKQDNSRMISDVRSAVALVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR32</accession>
    <name>A0ABM1VR32_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">von Willebrand factor D and EGF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106011390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824874.1">
        <property type="nucleotide sequence ID" value="XM_035968981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011390"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36191">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36191:SF4">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UMOD/GP2/OIT3-like D8C" evidence="4">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="318"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035824874.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="43712" checksum="E0F06FC3F04E87AE" modified="2025-10-08" version="1">MDLKRGPSYVTGFPEAPLCDIHLKEGWYRFTSGVGGMMPESCPDRLHCGTVVPIWMNGKHPTVAEGTVIRKACGNFENGGQQADPCCEHSVNVAVKNCGNFYVYYLSPTPSCPVAYCAGNKVPCPLGKWSATGLAPCKDAFPLITTEPKLSDPIIDPNNKAFHFNCEVQYPKHDPDQRFEVVWTFDGKEDPHVPPQILSDPNRTARLDGHWLKGHVNTNVGCKVRAFFSGNQQQKSPFLKSNTYYAGIQINPGKLTVSERDMEKNVTISSTIPILCDHNTSCCLVFKLDVDQTTDLSVQTMCDYSLCKEDWDPKTRSASMQIYLPSGAEVKVTAHATAMNLYLTTPGTDRSLAKGLCGTNDGSKSNEFTHPDGLEDKVCRDGEGRCIPVDFEEAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSW2</accession>
    <name>A0ABM1VSW2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adhesion G-protein coupled receptor G2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825504.1">
        <property type="nucleotide sequence ID" value="XM_035969611.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853694"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="372"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="665"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825504.1"/>
        </source>
    </evidence>
    <sequence length="724" mass="80262" checksum="6B447777520C7629" modified="2025-10-08" version="1">METNRCRELTCARGKQLVDSRCESKVKVANGLAYEVSLTLTGAVSEKQTAKMTQDIFPGTDRDSDVNEISQQVKGHFLFLLFNKTFRDFSSDTLLTYGKSHNFSETTTTTTTTTTTNNNNNSTTTTTTATKKTSTFSVSFYAKLLLQHSVVVQDFESKLLAITDNRTWTINVNGVPLDLWSSYNIPPAGQLLKNLAPPNDVTYRPVKDGVSPLPASPNVEPTHYYYYHNSPYSPNSRNFPARNRFDLSFNDETTSDDNTGDDDDEKEGMAFILVKRALQCPRLTFNLSESAEVELIAVNSSADEKGGQTTTTYELRHTGSGETFSLQDFYMSEERGETSVVVYLCADAFLKYLPTVKTTNNVTSIDLFGVGLVVTSYVCLGLSILTLSLTLLTYGLFASLRTLPGKATMGFSSTLLAAIILFLIGGFLDDVTVLCEVVGVATHFFLLSAFTWMVICTAHMYYVFTKLLEHKVAEHETKSRFLVYVLISFLIPAVIVSLTITCNSIYQASKDNDDNNSTDIRSDGDGNRFVTCDAPTDWIGYGAGICYLSNKLSLLLAGVLPIVLACVINLGVFFRAMMALRSMTSQQKLVRKEATNSLLIYVKLSSLTGLNWLPCMIAVFVSNVVLWYLFLILCGLQGVYVFAAFCLNKRVLALYRQRFEPRRSRKDAKKYARPATQGSEGKPDQRMLKEGTDSSTLTTLSSHLDSSESEGKPGRQKLVENTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT98</accession>
    <name>A0ABM1VT98_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101861996</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825640.1">
        <property type="nucleotide sequence ID" value="XM_035969747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861996"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="409"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825640.1"/>
        </source>
    </evidence>
    <sequence length="852" mass="95705" checksum="9F7F1EAF2859B026" modified="2025-10-08" version="1">MSARTKSSEPPETDLDYYARPENYTGSNLNTLTRFLVAKDKEVSKKNKQSKKKSKRSDERELYKRYRHILPPDLYGSPSSSESNSDSENEKENVAELVSDKNGRSSTHYDQGAKKDQTQQTSKEKAESTDNDSAVRVKMILNNEDVVDTNSDSGYESRLRSESEQFGDSTGTMLDSEQSFADKEGRDRSRDRKQGKNKDNASATTFAGSSENNTNLFSLSHMMLGTEAQRAGERGGEEEGGGGEGGGGGGGGGGGTISEPDSRSSTVTTPTRTPLLSRRVNLAKFISVKTKLSSLAREARQTVHRQRFQRLIVGVNAVLKLAKAIIKPTDSPSALLKTFTAAATLDQPKPDDQSENMKNYGLHFDPSYYKANKEISISNEVKSFLRLPPAQRSTEQIQTAMFGLQSLPSFAEYPLHMQEKLTRVAWFEVVTPKRTIIRQGHFAENFYFILSGQALVTIHKPGEVSSQTAGMMRKGTSFGELALLHHSRRTATVTSHDTVQLLSIGRDDFFDIFMSGHGTDQMPEHIRFISQMDFMKDWPLERLLERPDQCLLHFFKRNMVILKDSKDSEWFYIVKSGSCQVLKQLKGVTGHLGPLRQQFLPSQSLMGHLQSGASFQESRIDDGRTLQRRKLRTPLFDPDRFVQQREARERREILSDSAGETSESERDVYRDGNDFQGKAFSKLRYARKPSTGTPHFGRRSSRHSPSSHMAQSPRRQRSRRHLESTPVPDPDNPLLQETQPVFVQVEILKPKDVFGLDLVNFNNSIESRSSSVSLVSLGAECIMLSKSFFIRHANDRVKKHFTDMVQPYPDEGTLQSSLQGKADWELYKKSLLGKLTSPKPTGLRGQPLTARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTD3</accession>
    <name>A0ABM1VTD3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="5">5.4.2.11</ecNumber>
            <ecNumber evidence="5">5.4.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11 12 13" type="primary">LOC101861478</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17765"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="EC" id="5.4.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="5"/>
    <dbReference type="EC" id="5.4.2.4" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005089807.1">
        <property type="nucleotide sequence ID" value="XM_005089750.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938015.1">
        <property type="nucleotide sequence ID" value="XM_013082561.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938024.1">
        <property type="nucleotide sequence ID" value="XM_013082570.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938028.1">
        <property type="nucleotide sequence ID" value="XM_013082574.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825671.1">
        <property type="nucleotide sequence ID" value="XM_035969778.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825675.1">
        <property type="nucleotide sequence ID" value="XM_035969782.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861478"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012938015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012938024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012938028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035825671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035825675.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28929" checksum="13C47310008D805C" modified="2025-10-08" version="1">MTSPRYNLVLVRHGESTYNRANLFTGWHDADLSDTGVKEAIYSGQLLKRHGFDFDIAFTSVLKRAVKTLHFIQEELDALWVPVVRSWRLNERHYGILQGLNKASTVTSYGEEQVHKWRRSFRTAPPALEPTDDRSSQGRPPYTNLEPGVVPATESLQDAMARCLPFWYDHIAPAIKSGKRVLIASHENTLRGLITHLGALSNTDCSDFRMPNAIPLVCELDEDLHPIRHYFLATPEEMETARTNWPANEMQNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTG4</accession>
    <name>A0ABM1VTG4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cornifin-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825706.1">
        <property type="nucleotide sequence ID" value="XM_035969813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477697"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825706.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15590" checksum="02E23C6D89EA0696" modified="2025-10-08" version="1">MPVVPRSPLTMIPGGTSPPQPVPQNVHTPGHAKPSVTSLPSPCPDLPQPADVPDPPAHDPSMPTVPESRQELAPDPRPAVETVVPQPQAQATQRALRSLQPHNAPGIQEQDAPIGVSTPPGGPRRSARLLARQSPKPIDSKSYSDSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVL3</accession>
    <name>A0ABM1VVL3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium-dependent phosphate transport protein 2B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101863682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826455.1">
        <property type="nucleotide sequence ID" value="XM_035970562.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863682"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01013">
        <property type="entry name" value="2a58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037997">
        <property type="entry name" value="Na_Pi_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035826455.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="68145" checksum="9BF9A95D37922DE1" modified="2025-10-08" version="1">MHHGQSNHGFTGDNQDSYGSLADYKSSVPSYEFDDPKDVKAKTTEEKKEQNEEDDAWALPELKDDTVPWEELDDKGKFLRVAWLALRLVLLLGLLYLFICSLDFLSSAFRLLGGSCSPPPPPSLSLSLSHSLSLSLLGLMVGVLATVLVQSSSTSTSIIVSMVSARILSVRLAIPIAMGANIGTTVTNTLVSMGQMKDKGDFRRAFAAATVHDMFNWLCVIVFLPIEVASGYLYRLTDVITSDLTYNVSDSSSTNPKLLKAITEPFTKTVIDLSSSKLELIAKGVDFNGSLIKSGNFFLLSSGDHLFSDWEGTDAEAGAILLVVSLALLCLCLICVVKILSSLLKGTIAKVIQRVVNADFPGPCKYFTGYFVILVGAGLTILVQSSSIFTSALTPLVGIGAIHLERMFPLTLGSNIGTTVTGILASLTSDPSTFKDSFQIALCHLFFNISGLLLWYPAPFMRKLPINMAKFMGQTVHQYRWFAIVYLFFIFFLAPLFVFGLSLAGWEVLVCVGVPIVVLVICIIIVNILQDKSPKYLPRRLRNWESSGIPAPLRSLEPYDRVFVKLSSFCKCCLKEKEQDDTNGQVNMAYDEENKIESNHHFKGEMVNGNGCDFKGETTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWL2</accession>
    <name>A0ABM1VWL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478029</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826804.1">
        <property type="nucleotide sequence ID" value="XM_035970911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478029"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826804.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17015" checksum="6BE1505FE609F284" modified="2025-10-08" version="1">MEDYGIHVFVGYADDDLRFVRFVLRRYLEEDLNLNTYIHQRDLGAGYLDQQLLDAIQDSWRLVLVLSANFLRRYEKAHLVMKMCTSAVTPVNPDRVLVLVEQGQGRHVPDYVLAVLDEEKLVRLRSLNEELGYEQKQRIKHLILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZ07</accession>
    <name>A0ABM1VZ07_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Protein yellow isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101862766</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827649.1">
        <property type="nucleotide sequence ID" value="XM_035971756.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827650.1">
        <property type="nucleotide sequence ID" value="XM_035971757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862766"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045023440" evidence="5">
        <location>
            <begin position="24"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827650.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50368" checksum="B2AC6E81267184BD" modified="2025-10-08" version="1">MNHRAVLLTCFLCLALTQNEVDSQKFGDVQAVYEWTTLDLDWPSEAVKEEFINNGSFAVDKNVVSGIKVYKNEVYLSIPRWLSTTGIPVSLVKVVKVGSEVKLRPYPDWASQTVGDCQALQYVQSMEIDPNTGRMYVIDVGRNGLFAQSGAQNLCPAKIVVFDLHTDQRVASYDFPDDVVKRDDNFLNDIVLDYVDGQVKYAYITDVNAHSIHVFDFGTKRAWSLNDEASMKAEPDGGIIVINGKNYTFSLGVNGIAMSPNFDYLYYSSIGAYSLYQVPTSTLRNGGSDGIRLVGKKGSQSDGMAFSCKRLYYGALSKNAVCYWDIEKDMRDQNKDISHVTLNTQTQLVKDDQKMQWQDTFAIDEEGYLWFTADRLQLLFTNTMNFTGSEINMRIYKVFINETSYLHGAPGRTNNNTAGQRFGGTLSIINLFWSLFLTVFLSLKRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0S1</accession>
    <name>A0ABM1W0S1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable C-mannosyltransferase DPY19L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101861843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828264.1">
        <property type="nucleotide sequence ID" value="XM_035972371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861843"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20177">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047462">
        <property type="entry name" value="Dpy19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF3">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035828264.1"/>
        </source>
    </evidence>
    <sequence length="740" mass="84219" checksum="7F9A8F3DA10E1BC0" modified="2025-10-08" version="1">MFWIRKKMTGPQKRKGNLTQTKDKTPLVATGNGSTNIPDAKRGKKKIKPAEDSSGNNRKDSEWSIAKVLNLVCGLAVMAGISYAHSLYMYQIHENNMWFTNIKEVEREISFRTETGLYYSYYKQLVNASSLWQGIKELTEDRLTEHPDSINILERMNVYQELFLAAAYRGLGIEMPSILFYTYSIFALHGVLVAALYVTAWSLTGSWMTGLLSAAFYIFNRLDTTRVAYTAPLREHFSLPFLWLQAAAITVFFQNKMSAITQRASQVAVLLSTLFFCLFWQFNQFIMMLQGFALFGVWVLGLVPSGKVRSVVVCQQLSLFTVCLLQFGNKMLLGSLAVSFNFAFLAMILLVGDNPRPMSVFKHIFRVAAFSVLALVVMVLLSSVIKALLQVDSDEHIFKFLQNKFGVGDKRDFDSQLYLCLGIFQFMGTDIFERLMSNFVLPFYVASHVGMFGYLVYTVFKRWRVPPSSGDRAEKPPDLSDLSHNNSRSALLFHTVQSIFFLALAIMTERMKYLWTPYVCVLAAVGLADQAVWARLLRLCNIQDSFKVSVARNAVVVAVLGIMTAVLLPPVMKDLEELKEFWDPDTVELMEWIXXXXPLTASFTGSMQLLAGVKLCTSRPITNHPHYEDKYLRHKTKQLYQIYGKREPEDVHAILKSFKSDYIILEDSICRAPPRDGCRTPDLVDIDNGIQPDDDSVKIPGLVKSTVPSFCENVRHQKPTYSKYFRTVFVNRTFRIYKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W213</accession>
    <name>A0ABM1W213_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101864027</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_035828706.1">
        <property type="nucleotide sequence ID" value="XM_035972813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864027"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="314"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="387"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035828706.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="69154" checksum="F0542FE8F892B958" modified="2025-10-08" version="1">MRPRCSRWWMARVTAVALATTICVYIMSLKSFQILKPPKVRQKTAAVHDQPFQRNIFSKWISGVKEVNIPPYVPLHKVLSDLRPTEYTKRKDTLIRRGFGLDDYVTENGEEAWIENGVVYRSYPYLEPAENKYYSAHFEPYIPFDPEVFFQGQREKVEMFKETTERNGRKQVQGTKVKRKIILWYIQKMSAPKLGDLQPLRMCPDLPCLQTSNEAYVEDSAAMISLLNTCALMLILLDHTLFGIPLSHELLSTGSIIENNKHHNLWVDLCDVSPSRGEWRHHNIMKPTLSGGNPLYFLTLSLFLTGQYIFGHPPARRPDQVLVYYQIEPPGPKHWSHGGPHRSPGWSSAFNWTMSYRLDSDVVTHYGLVRRRRKPRAPRNYAEILGNKTKLVAWITSNDETASDREGYVKELQKQGIDVDIFKHHPNCTRLRDPECTAMVGQKYKFYLALENSYCQNYITEKFYKYFDLDLVLITLGENEYSEIAPKETFINTADYKSPKELASRLKFLDSHDDAYLQILKEKDKYFSIHENHNAFPDGIFLEDRYEAVPVCHLCHRLWNLDRYRKTISNITEWYSASRCRAATNNIPDHGGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2G5</accession>
    <name>A0ABM1W2G5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetylcholine receptor subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118478772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828858.1">
        <property type="nucleotide sequence ID" value="XM_035972965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478772"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="101"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828858.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39122" checksum="CC68FED9A5691B9B" modified="2025-10-08" version="1">MVSSACSTPCRLSTRFDSTYFPFDQQRCTISFIWMSNEASMRVSGFELTRMDSPIGGKEEWTIHDRGIRLANFGLPKSQFQMIECEVTLHRRHLFYILCVMVPTAVMSIMVSLVFWIPPDSGEKVSFLVTIFVSNTVMLNFIADMLPRSMSHVPRLVEVALFAMAQGLFAMIATMFVMRRHKREQEDEAEQNDTLEEEANARLDILETNPSLAQSHENKDKDLGIGDADVKNNLNEKPTETEIRCKIRELRRKISRFFSRGIRLRVLPEVTTCRNCQKRKQKSRRGRFYVTARMWDRIFFFASAIVGVVCYVRLWYLWYVMSGQTGMFEPDMRKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2W8</accession>
    <name>A0ABM1W2W8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101846392</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829011.1">
        <property type="nucleotide sequence ID" value="XM_035973118.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846392"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22248">
        <property type="entry name" value="Rcc_KIF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056533">
        <property type="entry name" value="KIF21A/B_hel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056532">
        <property type="entry name" value="KIF21A/B_hel_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23203">
        <property type="entry name" value="KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23204">
        <property type="entry name" value="KIF21A_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="412"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="637"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="864"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="288"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="462"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="711"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="874"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035829011.1"/>
        </source>
    </evidence>
    <sequence length="991" mass="111528" checksum="68CC4140C87AA744" modified="2025-10-08" version="1">GSGKTYTMGTGFDSVLSAVTDEIGIIPRAVDHLFLGIEERRRQAFENGEPAPDFKVTAQFMELYNEEILDLLDTTRDPDSRGRKSHNRIHEDAGGGIYVVGVTTRPVASLEDTLQCLKSGALSRATASTNMNVQSSRSHAIFTLHIRQHRVVKDEGPPLDEGKDTDSTQTEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKMKRGSHVPYRDSKLTRLLQDSLGGNSRTLMIACISPSDRDFMETLNTLKYANRARNIKNKVMANQDKTSRQLAMLRQEIAALTQELQDYKSGRRTVDADGLECVNDLVTENAMLQAENDKLRQRLKALQETVEGLKARNSNLLSEAALASVLGADGQASNEDVSNLIKKYIQEIEELKLTFCFVDAAQDNDDLGDEEDDDEDEDGDSPPDSSSESEVEDRESDNVHEDLYNLTCEISIKQKLIEELEQTQKKMSTLKVHYEDKVHQLQQKIKETEMERDKILSNIEKISSSSADSGRKVKQEFEKKLGSLQDELKKMQTEQRKHNKIQKNNSQYERHLKTLQHELSEMKKTKVRLMKQVKEEVDKNKTNEARRSKELTQLKKEQLRRDNIIKTLERQTLQKDAVLRRKQEEVEALRKRQKPMSSKAAGRVGKYDRPTTIPIAPVSSMRRRRKVEFSPKAAKQKWDSIDRNISSVITKRQTISMLERDMDVWLKQRDKCTKELEKYEKKRKDALNSNQPEEVQRKLTRTVEGLSLKVENAQENINECQSNIMQMEEAKEEGESSVEVNSLLETMSLEEAKYMIEKLYQRSLDKGVCMAQKESEVRELQGRLHQTELNNALQQDLLRHMMDGHVSLEVDDLMTHNDEPDDAESTSSSSSSSPAESMLESAMGPLSPGVVVPSQDTLSRREKARRKTATAQDMLYATGGDPAPSLLPVLEAPSERPSTVVNCGRLTPPLVSVKEASSSGSDGDHRSDKIRTSTARASADGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2Y1</accession>
    <name>A0ABM1W2Y1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen alpha-1(XII) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829024.1">
        <property type="nucleotide sequence ID" value="XM_035973131.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859054"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.20.10">
        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="466"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="744"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829024.1"/>
        </source>
    </evidence>
    <sequence length="768" mass="82758" checksum="A2A5A49C17864EA2" modified="2025-10-08" version="1">MCGKPVDLFFLIDASDHVGDANFAKELDFVTSVAQGFDVDKGTAKIAAMTYGSQDKKLFCFNTHSTKGKVINALKGATYTKGAATLDYGLHYARTNIFTTECGVRPDAGKVAVVFSAGTSSEPELTSEEAKRLQKTGVQVIAVGLGNKLDRNELWDVASTKGQVWFSKWELVRSIYKAVLTGACEAAEISLKVPGYTEYCFGKCASNLECVKTEGGASICTCKPNWYWEVTTQKCMKTPGHNQVCISKCSHNLQCLVSGGGNKCLCPEGHYFSTTSNLCVPDIGYQEECTTKDKCAASLECLKLSGKFKCLCPKGTHWDPKEKLCALIPGFGEVCTGICANHLECNDFGSGTLVCGCPVGYYWLVEKDKCFKIPGYLEPCTDMCATPLHCITGVCKCKDGFYYDTTDTKCKKIPTHLQECLGVCESNLKCTSKGGDKNKCHCPSGFNWDAGKKECLLMEKCKAPVDIMFAIDASGSLGEKNFKKEIAFAKEIAQNFPIGPSDAQIGALTFSGKVNVIFEVADLKDTNAVLQKLDTAKNTNGVTRTDLALNHVRVTSFDEEAGARKGAVKLLVVITDGKSTKPEKTVKEAMTLKATGVTVVSVGVGSGISMDELKVIATDTSMVFKAKNFDALDTIKAEVTAQACEAAKADPGYGETCTDKCASNYHCLEEKGEKKCLCPGGFYFDGTILACVKLPGHNEACVGRCSAQLLCDAKTSTCQCQGDLEYDTATKTCLLREPCRAPLDLLFVVDSSGSLGQDNFNKELAFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W399</accession>
    <name>A0ABM1W399_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Zinc finger protein 235</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101845894</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035829140.1">
        <property type="nucleotide sequence ID" value="XM_035973247.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829142.1">
        <property type="nucleotide sequence ID" value="XM_035973249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845894"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035829140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035829142.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46017" checksum="3EA020752728FED6" modified="2025-10-08" version="1">MVQSSSPDIDDVVASSSPTSTFSANTVSSLGSVVWASWDHGESSDVSTYPHGPLTSCHPVQQANGMRRRQGESSSCRFQTGQRVYRENVGGVPKETSSSDIGAMERVCDLHRSVADDKQMYDENLYDGHDTSLNDCAFASKMKAGNVDVESDVCCKIVSQTRPGKRLLGSSTRESCGKSRMFCDHKLSRGQGQGRDFNLSCAVSFASCTNSTDSTSTTPRKVNKEMDAGCRDVPPRFPVRESRYSREQAHKCSVCLEVFTELGNLQKQKRAHTSLRKLKRTHTGEKPYKCEVCGATFTWSSHLQTHKRTHTGEKPYKCEVCGATFTWSSHLQSHKRRHTGEKPYKCEVCGATFTWSSHLQSHKRRHTGEKPYKCEVCGATFTQGSSLQRHKRIHTGEKPYKCEVCGASFTFSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3B9</accession>
    <name>A0ABM1W3B9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101862081</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829162.1">
        <property type="nucleotide sequence ID" value="XM_035973269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862081"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046491025" evidence="1">
        <location>
            <begin position="31"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="212"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829162.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="43987" checksum="1F7F996F37212B01" modified="2025-10-08" version="1">MGTKSSPRTCPWTPALFLAVFLMIQAAVSSQRAEKELGDTCSQYECVAYGQICSADYKCICLLGWYQYPNTKQCTVSDPVQSLTATDVTSSDISVSWLPPPTSGTGEVIGYVLRVYNSDDLCLKRRYFLCAGCTQKPELRTNCPSSSETASSLTQEDLNNPAKIISGAMYNIPPYRNLTLTVSAIKNNAEGIEARLPFVTKIGTPRQYTSLEVDPIRDLDANQVHINVSWTPGVYTGPYFTHLDILKKELPSGVFRQEKVIILNEDNRTYLKTNLQAGWDYRVTVMAVIPRQNAENLTGPQFRPWVDVRMPSLPPGQVQLVSVRGDNYNADEMTLSFRCPPEMERNGTLRGFVVRVMVLSVQDNTTPQLQGEFFIPLGKHHREPCSYKVDAADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W427</accession>
    <name>A0ABM1W427_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein RF_0381</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101857620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829420.1">
        <property type="nucleotide sequence ID" value="XM_035973527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857620"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="338"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829420.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="49302" checksum="14D1E17DD43EF2EA" modified="2025-10-08" version="1">MSSKAVVNPALGEFFTAVRFSNCKKIKKMLKDRVVDVEDVDLSDSCRPTAIIVASELGLLEVVKTLMRAKPKPADVNAETRKGRRAIWWAAKSSNLELAQLLVSEKKCEVNYVDKETGCTPLYRAIISNCAPVARELVHAGADVNIRRLGFDIGAETPLIKSVQLNNLEICDLLVNSMCKIHAKTEEGLTALHFSIAYRRYEICEYLLKSGIKVNACSNHGVTAMTVAIEQHNPYMVRLLVQFGYKLNKPYKWSETPLEQAIKIHSQECALTLLHWGCSRKRKRKQTSYFYLAVNEKQWSIVRFLTHLNPMYLQETWIRAAKWPVSIYHRPDAREYLLNAAKEVWTLKQYCRAVVFNTIGKYAPVKIDKLPLPPVLKEYLKFNEFVKEDFYIQEPLEKVECPFDCPTICPQRNCPELDISISSDTDSEFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBT6</accession>
    <name>A0ABM0JBT6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIP41-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090053.1">
        <property type="nucleotide sequence ID" value="XM_005089996.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852971"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090053.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30296" checksum="23866E9D572C817E" modified="2025-10-08" version="1">MESAPTAGKATPKKAVHQQFQFGPWTMSTCKSHILESEGPQKEKFDKEMQLPQLPEMVFAENFLRVQHESGCGLEFNALDALRLVDAHSDPVKVAASKEWQGARSDCEHIKNVVSPFDWTYTTDYKGTIVQEKTGTLTVSPTLDRIDVEKLKKREPIHFYEDVLLFEDELSDNGTSMLNVKVRVMPSCFFLLMRFFVRVDQVFIRVNDTRIYHEAGTNYMLREFSSKEEKTVNIPAAVHTDPNEVSKHLKLTCEIFEKLEFPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBW0</accession>
    <name>A0ABM0JBW0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 2, facilitated glucose transporter member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090109.1">
        <property type="nucleotide sequence ID" value="XM_005090052.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846179"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005090109.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13313" checksum="70C4EF21156034F2" modified="2025-10-08" version="1">MALSETAEAWELLFVGRAVIGLATGWGLSLAPTYIMEICQPHMKGAAGQTNQLSQSFAILLSQVIGYEELLGNEKYWNYLLGFPVILFGLQMVLFVLCPESPRYLLLKKEDEEGARKGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC48</accession>
    <name>A0ABM0JC48_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neprilysin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101862847</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005090263.2">
        <property type="nucleotide sequence ID" value="XM_005090206.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862847"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="331"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="852"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005090263.2"/>
        </source>
    </evidence>
    <sequence length="989" mass="110469" checksum="05FD33781F352D53" modified="2025-10-08" version="1">MVREMADILTPSPHDFTESKFPFHSTSKLAMDTQSGSKLSMDTLSPLSPLATNIRDNGCATLPNGKPHNYTSNNGGSNNNNATIRSVVGDTGSYGKRSNHSSGDSSISSGGSSVNSVFFRGSGKPPVPAPHSGNEYVREPLKVSQHLHSKTIQCPRLYPHGPLPSDSSDTCLKSKIGLSEEVTYTITDEMDDASNQVVFLPPPPTDIDSDNDSVGGCDIGGPCSPRHHDWRSSRDLSKSPTSRTFSGQGNNKCLCCMLLVFVMSTAGLTAVLVLLYLGELQLAPIPKIPAIRDQGRAQLGEGALVREVCETPACLKTSSSILSRMNTSVNPCEDFYSYACGGYLEEADLSWFKTRLRESPDEIIHEHRKYIIDRLSTSYNPGDDKLLASSKKIFRSCLFRSNQIDERTRNVVSETVESLGGLLAPSDPADLTILLANVTRMFGASPFFKVLVHNDKNLSLVSTVADYANPWTSPRDFSRDRMSSKQTEAKRNLAQLNDMLVHLIRPTVNESDARNIVDNFLRLEAHIQRILNTGRDKLDHENEEEEMSCDPYSSRKTMGELQVKYNGFGIDWIAFFQNVLDTQDASDIKFCTVKLSLELQHLLKITPKATIRQFIILHTLIHSDLFILLNSNNHQSLVETPEGDLVSETQEEQCLDLLLHFLPSLEKYSGCDEQIIYETRLHAFNTLRNIREALYHVMTTSVLIAKDNAAYVTNSSMKPVMETVNQELVTRCQSGAGPQGPFDEYSFNSNMLRIIQYHHGEYFRGRLSRAARDLDLSALWISASVQDSHRTRAGPIVYPSPVPQPILYGSLGTFLASRVAEKTGINDLLEHHLELKLNHSIIMALAWRLDCLRVMYGQMKILDYGTQAYKVNGLKTKDQQWKDQLAMQLAHLAWMRSDMELDADHFIPGLTFTRPQMFFIAFAQTRCEKISERGILQHYVSKGPRDTPRIPGRQIINGVLRSSDAFSNAFQCSDNAYMNPMDKCRVITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC92</accession>
    <name>A0ABM0JC92_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc transporter ZIP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101845374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090365.1">
        <property type="nucleotide sequence ID" value="XM_005090308.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845374"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005090365.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="45080" checksum="FA20E3952651B02E" modified="2025-10-08" version="1">MAISVDVVKVIVLAGLLVMTFLFGMIPVFIINVVKKASHRNRSDSSSNMETADQRSRLSSYKRVLSFLNCLAAGVFLATCFLDLLPSVQRNLIQVLYDMKVYTGFPVAEFILVIGLFIILIIEQIVLTIKERPAVVQEENDPRQPLLGHQEENKDEMIESYHSDYSIGGICDEPHVTVTEGAGADAVHSEKVSRTRRQKVGGTQAGIQAEETDDSVSGGASFHREHANEEHGHHQRHSPADHSLQVHSPLRTLLLLLALSLHSVFEGLTIGLQLSVGEVLGIFAALVLHKSILSFSLGMNLVQSKLSVKSAIKSVVVFSLSSPVGIAIGITITDLWDSVSSGLIHGLLQGIASGTFLYIIFFEILPKEFNCESDRLLKVLCLIVGFAAVTGILFLDEDVKKPFCVIRESEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCA1</accession>
    <name>A0ABM0JCA1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-5AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090374.2">
        <property type="nucleotide sequence ID" value="XM_005090317.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847304"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1614"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1686"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1760"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1653"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1688"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090374.2"/>
        </source>
    </evidence>
    <sequence length="2080" mass="223096" checksum="6EA473A67D4390AF" modified="2025-10-08" version="1">TPLDENVTVSSVTPFDENVTVSSVTPLDENVTVSSVTPLDENVTVSSVTPLDENVTVSSVTPLDENVTVSSVTPLDENVTVSSVTPLDENVTVSSVTPLDENVTVSSVTPLDENVTVSSVTPLDENVTVSSVTPSDENITVSSRTPGDDVQVNVTSAGFNETSSPSVGNVTDLTSAVTLLSTINTTTEPGVIVESVGSDKSNATFSRDYLTTEVTDNQTDTTKITAAATAGKLTTVTTMQILTKAWERTTKQPKTTTTASLLTKEWERITPHDYTKRTYRVENTTSVVSENVTTERQENDTSISTTDFVTPDTANFTSYSENRTEPTTETFTTSGVVNFTTTVVVENVTAFDSENATIPKTEISTTMEVDSPSLAFENVTEEAIESSTSDQPPPPTKKREQEISTDSTLGVATKEWERVTTQSTTGVPTKEWEKVDLTTVPEDTERVTKDWEKAATSTDLTPGVPTKEWEKMTTQGTPSVATKEWERTSTQTPTAVPTKEWEKSSTQASTAVPTKEWEKSSTQASPAVPTKEWEKSSAQASPAVPTKEWEKSSTQASTAVPTKEWEKISTEVTSAAATEVSEKLSSGATSIVPTKEWEKMGVSTTPSATTQDTGLVTKEWEKRTSVVATKDWEKVDLSTEPPATTKDTSDSTDRVTEVTSEVPKLKIETHAVVQATVRPDVGHDNETMASTDEPSTPRKMDTSIAPTEEDDQEKTIGVETYVPASATPQVESSVAPPDDTERPKNASDLPGIRVETHMVESVTLQPIYNMTTGRDSSEGDSASTGAPGLDESATPIQRISDITTDDITSDSSSSSSDVPSSDQTTSPTPLANKTVASTSFPDATIYNLTTVPTYETNENTTTSQEVGPETFTLNLETHGVELITLKPQEEEEAVSSEIETSGSPLQTSTAVGTPTSSLVTESTSDISSPSTHVPGPEIKNISIDLETHGVQTLTLKPHEEKTTTTSSPDASVIDTDIPGYNTTVVPAATFTDTVSENTTDVYDRVTISEISNTTLDAPQQPSVGVHSTEIPATTDSTEIPMIQVKTHQVEEVTLKPHTASTEIPTSDSGIIRLETHAVEDVTLPPAFSTSPEDTETSTVNTEDWSSTEEILLKVETDSVVEVTVKPHTDAATTEPDRQTSDDVTVSTLSPDNVTFSTSSPDNVTFSTSSPDNVTFSTLSPDNETFSTLSLDNVTFDTVSPGNVTFDTVSPDNLTFSTAYTDNVTLTSVAPDNATFSTVSPDNVTFDTVSPDNVTFDTVSPDNVTFSTMSPGNVTFDTVTPGNVTFSTLPPDNVTFDTVTPDNLTFSTLPPENATFDTVSRDNVTFDTVSVDNVTISTASPGNVTFDTDFSDYSTTSTPDPDRVTSDTSASLDNATSARDNVTFYTSTPGPLTPENVTSRSLTSNTETKFSNTPIPTEPSTPEGPRIGVETHQVEEVTVRAHTQTTLSTTAATTALTSTTERGSMAQGTLSNTTSTAGGLIGVETHQVHEVSVKPHVQIELNDTDSTTTDSTPSATEKLIVAKTHHVEEVTLQPHTTAGEHMTTQTAQITTGASGESSVSTTTGSTVEKENFTASTNATVSNKTEGVASTTEDPNIFSSSLETVVSWFHNTLSTVSPEEHSVENATTPSSNTTRETNDTTQTTAPPFSDEQNSTTKPTPITTQQPTNIFSTISTLIYNTVSTILEEDSTTSTTPSTATTAAPTVTKEDSDANKTSGGGSIGYETKKPAIIAAIKVTTRRDGEKTVRWHGKSTPRKTSILETLAPSKDKKTESPEVSAPVTPAPTKLWYTTTTKDGVVAKTTDMTTPQVLTKWPMSTKSTKRPPIYRGPPRGVIILSPNKMVAYPSATLPPIVYVPIKRPDGSVTLVPGILVPDRGVTGRPFVTGIPNNKDVFYYTGKPGPDGGVHLYRVTKKTLSEGTVEERPGGETEVIKVYPKGGVPLGDDGKEPDPTHVKLTVYKVVKNVMEVSNNTALEAYVRARIMLRKTLKQLANLWKQCVKGVVEVVYVPSKQGIADYSAKLTVAYKNIQKAYVYGCNVLRKTYETTSLKLADYFNCVSNKYKTTNNYYYDILEGAKVSKRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD29</accession>
    <name>A0ABM0JD29_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101850529</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090918.1">
        <property type="nucleotide sequence ID" value="XM_005090861.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850529"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090918.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24848" checksum="27E54A04BE3E5103" modified="2025-10-08" version="1">MEKRLKDRPDDLERWKTTHRPNCHKNHTGSSGSMEVAAAAVMWGRSEQYGLRYTTMISDGDSKTYNELTKNPPYDGIAVTKGECVNHVSKRIGTQLRNVVADERKRGVALGGRASLALTQEKIAKLQVYFTRAVRSVAGSRVAGEDICFTGASEEDIKVMADAIKASYFHCVSTDAFPRHMLCPEGPDSWCFFNRAQARDEPVPEHKKHQTCFFKGRYTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDY1</accession>
    <name>A0ABM0JDY1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lys-63-specific deubiquitinase BRCC36 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Lys-63-specific deubiquitinase BRCC36 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101848939</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. BRCC36 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091457.1">
        <property type="nucleotide sequence ID" value="XM_005091400.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091458.1">
        <property type="nucleotide sequence ID" value="XM_005091401.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848939"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08068">
        <property type="entry name" value="MPN_BRCC36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040749">
        <property type="entry name" value="BRCC36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033860">
        <property type="entry name" value="MPN_BRCC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18110">
        <property type="entry name" value="BRCC36_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="227"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005091457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005091458.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31095" checksum="1973C8EF85A5EB3B" modified="2025-10-08" version="1">MSLKCVNLESDVYLVCLTHALSTEREEIMGLLIGEVDEERALHISSVVILRRSDKQPDRVEISPEQQSDASIKAEQLAKELNRPLRVVGWYHSHPHITVWPSHVDLRTQASYQQMDDGFVGLIFSVFNEDKVSKFNKIQVTCFQSRQINSEFHRAEVPLNVVPTCQIGPACLSSLVELPKILLQEEDEAYARVSDPADQDLLTRVHNASVFTKSLCHVMEVVSGPLLHSLEQRLQANKQRTAHLQEEKAQLEARLKALEQKSDRHQPKSLMDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDY6</accession>
    <name>A0ABM0JDY6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091478.1">
        <property type="nucleotide sequence ID" value="XM_005091421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091478.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29639" checksum="313BECD83C85D3B3" modified="2025-10-08" version="1">MGVFLSLFFRYAADTLQDKEASPSSRFKSRVDVTVKEMWVFFELVIAMGLVVIDDLDEYWSEDEIFSLPLFRSIMKWDRFCLILSFLHVCNNREQVPQGQADQDPLFKIRNFVTSLKDNFLRVFKPGRNIALDGATVAWRGPLAFRVYNPNKPDKSCIKDFELCDSATGYCSNLEFSTGKQDSSTFGATYDVVDQLKTPFLGCGRVLYVDNYYTSHDLFTSLKNQRTLACGTLRLNKRHGPSEVYAPETEEGRPLSQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFI4</accession>
    <name>A0ABM0JFI4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092501.1">
        <property type="nucleotide sequence ID" value="XM_005092444.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849278"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044994573" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="21"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005092501.1"/>
        </source>
    </evidence>
    <sequence length="581" mass="67050" checksum="1C9C7087ACB26074" modified="2025-10-08" version="1">MKEKTLFVVTLLLSACLVCCDEHDHLYKEGDEVVLWMNTVGPYHNRQETYSYFSLPFCKGQKKDISHYHETLGEALLGVELEFSGFDIDFKGDFSHTEYCFIDLTVDEYHAFTYAVENHYWYQMYIDDLPIWGIVGEVDESGEGHFIWTHKKFDIGYNGEHIVDVNLTSETKVKLKPNSKIQFSYEIKWHPSNIKFEDRFDKYLDPNFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKEEDLDDMEKDLGDEYGWKQVHGDVFRPASNSLLFSALIGTGYHIGIVSLCVILFTIVGELYTERGSLLSTAIFVYAATSPVNGYFGGSLYARMGGKLWIKQMVTSAFLMPSAVCGTAFFINFIAIYYHASRAIPFTTMVAVTCICIFVILPLTLVGTVLGRNLSGQPDYPCRINAVPRPIPEKKWFMEPAVITVLGGVLPFGSIFIEMYFIFTSFWAYKIYYVYGFMLLVFLILTVVTVCVTIVCTYFLLNAEDYRWQWTSFMAAASTAGYVYMYSFYYFFFKTKMYGLFQTSFYFGYMALFSLSLGLMCGTFGYLGTSIFVRKIYSTVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFM6</accession>
    <name>A0ABM0JFM6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC101847409</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101847409</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005092578.2">
        <property type="nucleotide sequence ID" value="XM_005092521.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847409"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="13">
        <location>
            <begin position="392"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="402"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005092578.2"/>
        </source>
    </evidence>
    <sequence length="598" mass="67613" checksum="EAB7FBB2F9F5F59E" modified="2025-10-08" version="1">MLINRRAIDKMGRLLIPLYLCLHLVDSSVITVLIQPRSTILPWSEPEQSYQLDDIIANETIRVDHVIHEKDLITFYRDVYLTSPKPLIFIDLRHHVCPFDIFPKRLLAYVTRSLKKCPHLSQETQGAKVEVTTQALQLLDFLSEFLVSWDSAATKQDREGFALLFDETGEDYFLLQHRKLHKKPIFEITLPLYNCSSSSHVTNLAANTNTKDVVVIAQAECIHELLMAVSLLRLPPTRFRWLLYSTDDNSVNCNDSLDMFCDVIKPVLLTERDKPKNRLVFTAEKILSYVHSGINIYTKGKKGEWFPSACQENCAVNCSECQEIFQQGLGQIPGQEFDVFRYQSDDASAKDSIIFDLHRLLPNGQRYIGNWSKDLGLDMSELAYPADFIDSRLTVVVVVEPPFVFRNDSGGGVPRYYGYSMDVLDEISRRVGFSYTVRECDRGGYGVLKNGEWTGCIGNVVRGEADVVLGALTVTAERDRVVDFSLPYYDFAGIQILMKRQAAEINLFYYANVFTTFAWCCLGAVVVATSLLLYAFEKFTSPGYRKGQYSEKPTLRSTNTSVPLTMFTVSNGSVASSVGTEHRSVDDRTSTTTTTTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGN7</accession>
    <name>A0ABM0JGN7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF-related serine/threonine-protein kinase isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093280.1">
        <property type="nucleotide sequence ID" value="XM_005093223.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850235"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14074">
        <property type="entry name" value="STKc_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14339">
        <property type="entry name" value="UBA_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF45">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="662"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="816"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005093280.1"/>
        </source>
    </evidence>
    <sequence length="1101" mass="119079" checksum="7CFC21D3EF27C2E0" modified="2025-10-08" version="1">MAGKRSKGGYDGKIAGLYDLEETIGQGHFAVVKLARHVFTGEKVAVKVIDKQKLDDISRSHLFQEVRCMKLVQHPNVVRLYEVIDTQTKLYLILELGDGDMYDYIMKHDDGLDEAVAKKYFQQIVEAITYCHRLHVVHRDLKPENVVFFNKLGIVKLTDFGFSNVFAPGKKLETSCGSLAYSAPEILLGDSYDPPAVDVWSLGVILFMLVAGRAPFQEANDSETLTMIMDCKYQIPPQVSAQCRSLITRMLVREPSQRINLQDIEQDPWLGDVDSPDSGLRISLPLLSREHVSEEDHNYVVQKMVEGKICSRDEIFQSLERDAYDHIAATYYLLVERRLRKLQQQEVAASSANNLRKQSAPSTNIAAGKPHLEPLMLSPRKQKEMKKTKTAPVHKCGGIPPTLVITPPIVEEPGARGVGSAAVSPGGPDFVKSLTTSMTLDRRTNHRKKLEGPSQHRMTMSANLGLPSPASAPASAPSGPLIPKMDEKGKPQQRVRSAPLTTHEGVKAVVAKKKSSAPSFSKIAILSSFFERKAAQESGALPPPQPHQRLFPWMGGRDRKSKQRVALSPNSPTSLGFSDVGHFHRVQSAGPDHCDPSNLVQSLVSPPGTHPSPASASPGMSQLSPEAMFAAIRKCSLIREESQDDDDDDDLDDFDMDSCELKPSKSLEFLDERSSDFSPASGPEVGLMPKLSQPPSAGHDPVNPRRPLKSVCSSPQLLNQIHEENESEDEDDFVPLKLSAPRGRYSHSGMASPEILRKYEQRRRRRGAGQRGASCSSSDASDTDDTEGRSRKDSKLKHKFVHRRDSSDHSSDTDGPSGGNNLGGGGRIGNGGSGAKTSSGGRSSRRDGGGGGGDGRGGGGNGGGSGGKGHQHNSRHHTLCASDSRSSGEDPNEWPVASNGHVTLEFGDENIDCSNNQNSNLKTNNFSKISLNNKRNHLTRQNPVIGHEGLAILNTDLHLLALSQKLSSISSTSPLSGGISLHSNTAMNNSNTLNNNNNKITGCLTSVLVAPAPSHERPDQYLGQHYPSPLPASSDCDEFSQISEYCERLMESQTSAASLCTGDCGPATGSRLNPAQGAPTCCKVGSAGPGLQVESKCCSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHA9</accession>
    <name>A0ABM0JHA9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101854397</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093648.1">
        <property type="nucleotide sequence ID" value="XM_005093591.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854397"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005093648.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9002" checksum="FF3ECBD6CA12D670" modified="2025-10-08" version="1">MSRRQTPSEFLNQIRGRPVMVKLNSGVDYRGVLSCLDGYMNIALEQTEEYVNGQLKNKYGDAFIRGNNVLYISTQKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHX0</accession>
    <name>A0ABM0JHX0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101858767</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094022.2">
        <property type="nucleotide sequence ID" value="XM_005093965.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858767"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049427">
        <property type="entry name" value="Acyl-ACP_TE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487:SF1">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20791">
        <property type="entry name" value="Acyl-ACP_TE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-ACP thioesterase-like C-terminal" evidence="1">
        <location>
            <begin position="248"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094022.2"/>
        </source>
    </evidence>
    <sequence length="364" mass="41912" checksum="5093BA12A72C7B22" modified="2025-10-08" version="1">MSSSVMKQLISISIRTLDSPLRHLRLLSTLSSPKQHSSCDYTAKSRFRPSRFSVRTRNMSTRAKKDLSFWQDNFKQWTVKDISVIQEPYSATLRVPGLTPESFNRYANPQAQSLLFVALSARVFMFHEPYNDAGDIFMDWARTTSDRLIFISSTEVSFSRALYDPEVKKTELDVKIKLGYVGNASVAMVTELYSPDNKDEPICSQVAQTVSIDKSTRKPTPFQDWFRDKFVGRGIRDRGLVIRPFERPENAFPYELKVRWSDTDGYNHVNALKYITFAEDAVHAALVHSESGEKTHNTALRGLTEDFLINGFKSMQISFQNESLEGENLVAYVWQPEEEDPSVVKCSIERNDQRICQLRFEYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIH1</accession>
    <name>A0ABM0JIH1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING finger protein nhl-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094396.2">
        <property type="nucleotide sequence ID" value="XM_005094339.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860966"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14954">
        <property type="entry name" value="NHL_TRIM71_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16524">
        <property type="entry name" value="RING-HC_NHL-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17170">
        <property type="entry name" value="DUF5128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="586"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="632"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="679"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="726"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="773"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="823"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005094396.2"/>
        </source>
    </evidence>
    <sequence length="860" mass="95547" checksum="FE404C7F434F3A50" modified="2025-10-08" version="1">MASSDVSLASEHVQRLLQCAVCLELFKQPKILPCQHTFCLRPCLEGLVDHRTRSIRCPECRADHFVPRSGVTGFPNNLTVIGFLELSQNSSRANDDRGRSERGGGGGDAGVVEAAPDNSSRGSASQQLHQMALRAASPPTMPVDAAGAEGGGCSVCHAEGRITRCGHCDQLVCNECRRIHIEQVKVDLSCLISQVRRGLPQITEQILTMGRKGTRLQNNCECVKVEITEAMEKHIRELKARERTLREDVDSFLMGELRTIRTYQENAEVEIASLASFCDSAESMLSMNRPIPDGDLMEMKRQSQEHVETVNCYEDGTIRPPNLKQIQASLESPFLSSTIGNFGDLIITSRTSGQREATSNVREPLPSMLDVPPSRRTRASVPPQAEHRPAVVLEVPAISARANSNSPREVRRLRQPSVYFADETPPREEDNTSRWDALSRSMRPNRRSRQERNSDTRIAALMGNDRPTLSQVMRNRARHRSLGALPATSEYSDEESPPREETQGRTIRDDAEEDSSFTDPLSSTYPGARSGQFLPPSVRFDIDLNDRGDDIDDSGNLGLFQNSNSPSIYVNSPRNRYNQKGTAVVRFGDRGSEPKSFTWPRGVAVSPMDDHIFVSDSSNHRVQVFDNSGKYLKSFGTYGQGNGEFDCLAGIAINGLGQIIIADRYNHRVQVLDRNGRFQCSFGSEGSSEGQLNYPWGVACDNMGFIYVCDKENHRIQVFQSNGAFVRTFGHYGNRSGQFENPHYIAVSPDNKVYVSDSSNHRIQVFSIYGDFLFSFGICGTLRGQMKFPRGLAIDHQGFVVVADSGNNRIQIFRGDGRFYTMFGSWGSENGHFKGLEGVAILANGNIVVSDRENHRIQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ98</accession>
    <name>A0ABM0JJ98_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Canalicular multispecific organic anion transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101860085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005094919.1">
        <property type="nucleotide sequence ID" value="XM_005094862.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860085"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="908"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="142"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="474"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="858"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1105"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005094919.1"/>
        </source>
    </evidence>
    <sequence length="1343" mass="149921" checksum="0D961B2D7CD797C8" modified="2025-10-08" version="1">MFGKMGSGSSSLLSNLLFTWTNRLVTPEGSGISIDLPQQFQASIWGRKTLEAWNAALQRQFVSDEESKQTDSFSVKTTGDASARKIINIPSEKTKSGSTKRSNSGSKNYNSPYYTNGQKKPVSTKNLVTLIWQVFGKYILHIILVVLVGRVVSLMCKPFLFTELMKSFEKEDNEQQLFSSKQLFLFVAIFLSLFTSSLLDEWSLYLADTASLRIKSGMSYLVFHKLLHLSQTAKYNLTAAKINNVVSSDLLDSARGIIWIALRVKSLFNMVGTFVILYYYIGKSSILVVLFLGTVVGFSSFMLGKQSVLYQTRGKAKDEKMSVVTEMLRNMKNIKLLAMETVFGKKVEALVGVEMRILTKIFLFRLVGLLAWSMTPMVATTLVLLSHIYFDTTGLALKADITFAVVILVNELRFSMFDLPVLFTTFYSVRAVFDRLQEILVAESVQSRRKLTFSTLSNPNVDTDKIGSYRSSAISIRNSTFCWDRGQAAFTLKADDISIPKGSLVLVTGTVGSGKTSFLSALCGEMEILEGDMYVNGTTSYVPQEPWILNATIKDNILFGSPVNKSLYEHVLTSCALNTDLESFECGDLFEVKDKGENLSGGQKQRVNLARAAYCQSDIVLLDDPLSAVDNNVARHIFYNLIGRRGLLGQRTRILTTGGSQWLPFADMVIEIRRLGQSVDDAAEYEAVIVQDVQTPRKHALKVNVKEEIDNAAGGDEGNNNAKFPKPSDWNEESPARSIDRETVKIYFKAVGLFSVLCLAILQVFPVFIDARARVGLTEWSNRIQDIYNNSQDLQTCARFQAEIKGPVCISDGTKEALWETNIYHVKLYFFQTASSLVFFVLYQILCSLRNSEATGSLASQLLWSCLRSPLTFFEETPFGQLALRFGHDVHEIGHEVPLSLEELFYRIAYILTSLIVVCYTCPNILLFATPVALISIYIQLRHVALEAKITTNRRKYNSFKYGRIQETIEGVHVIRGFHLRQRFLDMLVSAENESNAMTYAFYAQNRWLGMAMTYMSTFFVMSSAIFASVGESGDSKAARVGLAVMYSIDLGHHMNVLIKQTGRFIGSMYSVKRLSSFFDTPSEAEWDSDSRNTSLMSWPKLGHIRFKDVSLMYSNAGGPALKKVSMTFLPGQKIGIIGRTGAGKSSLVQVLLRLRDVSNGAVYIDNVDISTVGLHHLRKSVSTIPQDPVIFSGTLRWNLDPTGRHNDNALWSTLAQVQLDELVKSLPEGLGYVCKEGGDTFSLGQKQLICLARTLLEKAKIFFFDEATSSLDPVTDKKIQGVIKRVCSTCTVLTIAHRFTNVLDYDLLVLLEAGQVIAMDTPENLRNNSTFKTFFSGPDAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK34</accession>
    <name>A0ABM0JK34_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vacuolar protein sorting-associated protein VTA1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101850708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095560.1">
        <property type="nucleotide sequence ID" value="XM_005095503.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850708"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005095560.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="34682" checksum="0D630C55B52A5F6D" modified="2025-10-08" version="1">MAAPGLGSLPGSLKQIQHYLKTAAEHDKRDPVIAYYCRLYGMQKAMEIDRSSPEARQFLVGLMDYLEKVKGQLKDEEAVHNEVIGQAHVENYALKMFLYADNEDRAGRFDKNVVKSFYTAGMLMDVLSTFGEIGEDIESNKKYAKWKAAYIHKCLKNGETPIAGPMPEEGDDEAVGGAPAPGLGFDHITGPSMPPNQMTISQDSSQFPAPGAHAPPSTPQDPTRGDYQQPAPSAYQPAPSRSPQPVPRSLPAAQPAATSTYPEWTPPANPAGVKLTAEQYQKGIKYCKYASSAMQYEDSATAIDNLTKALKLLTTGRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKB7</accession>
    <name>A0ABM0JKB7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101848738 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095720.1">
        <property type="nucleotide sequence ID" value="XM_005095663.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848738"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF2">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="2">
        <location>
            <begin position="426"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095720.1"/>
        </source>
    </evidence>
    <sequence length="627" mass="69979" checksum="872B8F084C7799BF" modified="2025-10-08" version="1">MMEEEIDVAVSLDELTLDLAGDVPNTNKDVDIGMPDFHLDSSLTGDHFKIDDFTPNISSKPQNAHSETQMYTKDQGDQGVGHCYQVDSLDKAELSETTDIPVDPCHMDPLENTIVLDLDSATEPGEVDDFEAEIPPLALFPSTKNDDNSEDSDSEFEFEVPNRPPLASQQNPQQIPASTHVFKEANSITKDQKVSGEKADQYDIDLQPVQSEHLVPDILTPRDKTVSDFTYSDFTGNIESSGSKFSSANVGEISVSSLSQPTIHSYDCPSDIPSDGGKYARGITHSASETGYTAAEAIDRNGASSPDSTDNDETGASKPSIVTTAEDWEDVQTVEPGFAKPGDQLRGSSNVVDSKPLIEISDAWTQFESLDYSSVKDQIKTNIERKGFSAFSHLLFGPPKLHKDLLEQRDLFFCIAATPMDNENQSHIHVLQTVYRCLTGSKFDCQRFGGHWEEIGFQGRDPATDLRGTGMLALLHILFFLRDASTKQLSRDVYKLSLHPTQNFPFCIMSINLTRICLQVFREELFNKECNRRKNVISTMNDVHAALFLRLYQLWKKGKTISDSGFVLQEVETYCRKHSKNVFKDMGMYEKLRKQQGPFGEHMEGDPSFFSVCKEDECDDKSPAELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JL43</accession>
    <name>A0ABM0JL43_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein DD3-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096259.1">
        <property type="nucleotide sequence ID" value="XM_005096202.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856418"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053320">
        <property type="entry name" value="Protein_DD3-3_O-glyco"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35170">
        <property type="entry name" value="PROTEIN DD3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35170:SF1">
        <property type="entry name" value="PROTEIN DD3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047477300" evidence="2">
        <location>
            <begin position="22"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096259.1"/>
        </source>
    </evidence>
    <sequence length="780" mass="87992" checksum="349530A35DF4FB2B" modified="2025-10-08" version="1">MNGVTSSILCAVTILLHLADGDIYLHNPRGSNNRLDESSRARANGNNIFDSQNNERGGYNVGSLFYYQGSTLSVEWTNQHSCHDTNNHCELVLQYMCHDNIRDGVSTQTIPTNPALCANYNCDLDRKYRMHEDSSHYFQCLYRQRNKGIFTADQNMNNRERARNTRQNPAGTRRGYECPEERDYYPYWHPSPWVDIAVMTNDVSRCHYYRNESQNVKSKWDCVFPKAVMDKFKVNRVNVQLPNNEEDCKKFELPAKIKSDIRKPQWVEFPAHGVAAPDCRETDFTRDNHLGNGIGGYPNMFNWTIPNNVEHENCILRIRYNISTSDYDGWTANSSFNANPRRRNDGAKVPLADRFGFESEEIAKERGYIFKNNPVVNVFDGLDLDLRLAVNTAQFGRTFQDRSHTFAIRKRPDWLQGQTVHNLNVRGKRGNIVQVYPAVEYDFVPNDLEVAVGDYVHMQWTGSNTNPRNNDGQGLAGTDRNNLILLTAQKFAEGSGTADYRGAKHGHYGTNYPMRAENSTFLGLSQEDALTLAFLDPGQFRGEVSELDDAGTYFNLSPRKTTSAGTYQYMCTRNNNFSNRDQKGRVVVNASPFKREAIGQMGGEVALDNGAARMSVEENTFSSLKNVRLEKWSVSEGEAAMSRVNRALGAGDDYASDFVVLQPENLIEEGDDDKFFTLRIQLSDDSDDVDVYYAPSDFSAWSKADAHVGGGVATVRAQHGGVYVARSKSNVGMIVGVVIACVVVVVIVSGAVFYFRRNPTKWQAVKTNCRNAERSMKNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLH9</accession>
    <name>A0ABM0JLH9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BUD31 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096520.1">
        <property type="nucleotide sequence ID" value="XM_005096463.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855863"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00998">
        <property type="entry name" value="G10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005096520.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16959" checksum="B966507BA8FB76E1" modified="2025-10-08" version="1">MPKVKRSRKPPPDGWELIEPTLDELDQKMREAETEPHEGKRKVEALWPIFRLHHQKSRYIYDLFYRRKAISRELYEYCLKENIADKNLIAKWKKQGYENLCCLRCIQARDTNFGANCICRVPRSKLESGKIVECVHCGCRGCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLS1</accession>
    <name>A0ABM0JLS1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101849454</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005096662.1">
        <property type="nucleotide sequence ID" value="XM_005096605.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849454"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="450"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="802"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1305"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="886"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1145"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1215"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1237"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1248"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005096662.1"/>
        </source>
    </evidence>
    <sequence length="1341" mass="141550" checksum="71287546530D80E8" modified="2025-10-08" version="1">MEPEEDNGCPSQGQNLHDLQNYLVTFNKEIESGDDVLSSMDVDGEVGDLYNPTSGSSLQEAGEPGVSGQFSSGFYSEQGILDSTLADESAQQMQSLVGGAEGDADISAAIKQEVGAMEMDAVQAQIAGFGDTQLSQGPLDVQAGAMSQGLIMTSLGDNLDPGAGKVIRIVSLGEDGQFLSMADGQQMRILSQEDLGISSDTLSSTDASLGIQGTDSVSVGTSSAGSSLLSTLAGTPSSSASGLVMDGGLGGVMVAAVSQPESRGAAQLFSLPGAGDGAQTRLVSLSQGATALTPEALQMSGLLPTESLGGELGYQTITIMPSELNQTGDMNYVLIMAPTDGGDKDMSSPINSQVLDLKQETQELSEEVVEINGEMKRVLRMVPKKYVSPLGPQLMCDYCSYTSPKRYLLTRHMKSHSEERPHKCSECNRGFKTPASLLNHVNTHTGTRPHKCKTCDAAFTTSGELVRHIRYRHTFEKPHRCPKCDYASVELSKLKRHMRSHTGERPYKCPHCPYASPDTYKLKRHLRIHTGEKPYECDVCHSRFTQSNSLKAHKLIHTGNKPVFQCNLCPTTCGRKTDLKIHFNKLHTVGSPLECKKCGKVFSDRYSYKQHVRSHDGDRCFKCEDCDFIANTERALDQHAAIHSGGKRFECNVCHASFNLRQMLEKHKQWCTLDLESLEDSSSTSTAKRKDTEEEASSGQSVLYKSPLGRPPGPSSNKEGPRGEDSNSNSAAESSSSSSGQPQGPPSASDTLHRNLLQDIRSGKLGDVPQVVIVHPDGSLEEISSKLPGAKLNLDDILSTLSSAERTDQSPGQSLPAPSVPEAEADPGAENGAVNLLSDDADSDKEEDLSSEAGDNGESSQCEAGTQAELESDTDSVEDEASMDSVPDKAGENHTDKRNVSEGSLVNSSGADGHQHPSVTMVTSAAAKASVMNPMISELNPSTLSVGVTMSGAAPPPPLVSISIPPLSTSSTTLPMVSVLPPISASVAGEVASGSSVSQDKDAASGTGSNSNPQYAVIKGYTYMGDNSDQPTFVNLAVDRDSVMNLFMSLGQHAAVGGQSLSLPVTAAAEMAGGATSAAHASLALEGTAAAAPTEEGGSAIPATVQLSELTSFPNVSASFVLGPSEIGTVKLSDTNTDQGVGGTGKDKVDQGSDRTESAGQVSVVQLRTVQDSSSSDGNEREQCGEGEELSSSGFEAEGENNSSDREDEFGEPKSLSSSSTSTVVSVNVSLTNADVSKSRRISEKRSGNSPSSDQSGKSRSAPHNVQQQNQEEQRKNSNVVTGKMDLVSPKNVKETIKVEVAAEDSSKLVQKRQGRKRSAADPSLVMSGKRVRKALVKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNL8</accession>
    <name>A0ABM0JNL8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lysocardiolipin acyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097905.1">
        <property type="nucleotide sequence ID" value="XM_005097848.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858709"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="82"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005097905.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="43147" checksum="E68C519348657F2D" modified="2025-10-08" version="1">MEFRNPFGGILLALMLFLTSTVGTIVMVTPALPVIFLSPQLSRRIMDFLIKLWFLLAVALYELLMGMKIVIKGKPARRGNSALILSNHRTRLDWLFLMSYLCRFNSIEEYRISLKAPLKKFPGAGWAMQCAGFLFLQRKWDLDKDHIANGINYFSKVKSKPQFLLFPEGTDMCHKAIARSHKFAEDKGYPKYDYVLHPKTTGFIHFVKEMKKGQILDSILDVTVAYPKTLIQSELQTLKGEFPEEVHFYVEDYPLETIPETDEELEKWCRELWSKKEERLRRFYESKSFENEPGDNEEEKNASPLSEEAVRSKLYSVVAFWVIFLLVTFIALFLYPYFRLFCLIGCATYVIIGFRHGGVDNVIYTAVKHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPI6</accession>
    <name>A0ABM0JPI6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Neuronal acetylcholine receptor subunit alpha-3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC101845238</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005098514.1">
        <property type="nucleotide sequence ID" value="XM_005098457.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845238"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19033">
        <property type="entry name" value="LGIC_ECD_nAChR_proto-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046253616" evidence="17">
        <location>
            <begin position="23"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="46"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="263"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_005098514.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="63453" checksum="EE8362675C4EC0AB" modified="2025-10-08" version="1">MACMSLVLLLALSVMMSSEAVAAAKRESGKGQNDFDNELNITSKEKLLVKRLLKRYDKQGKEGRPVVNTSDAVRVEFGLSLIQILDVDIKDQVLKTNIWYEYNWNDMLLRWDKEQYDNISDVRIPSDKIWLPDILLYNFADDRLKEQRNALSVVNSEGHVLWMPQAILRSSCAFDTLFFPLDEQTCILKFGSWTYNGLKLDIHFIPDRDKFELGEYIENNEWHIVENSGARHVKKYTCCPEPYPDLKFKLRLRRRVAFYTFILIMPCALLSLLTMVIFWVPPESPAKLTLGMNIFLAYFLLLLVLADTTPKATARIPLIGAYFCMNMVMITMSEILACMVANMHFRGVRINRVPKVLRLFMINFMARVLCLRDKIIEKDSTPVINCPPKKRWNVGRVGGDNTRPQYPYTDITCAQVRLLNNDVEKRQIYHEGGDGGGGDGRGGPESRGGGDCGGSTGFQFPPIGDEFLSHVQSNAKVLEEVKSIREILERVKEKKARAEEKDKLAREWRIVAMVFDRIIFAIYVVINFTGLLVIFIWQINREEQMVKGFENST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ05</accession>
    <name>A0ABM0JQ05_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101859015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098842.1">
        <property type="nucleotide sequence ID" value="XM_005098785.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859015"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005098842.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23111" checksum="E592D78CF5B18B57" modified="2025-10-08" version="1">MSILAYNGAAIMAMKGKNCVAIAADRRFGIQAQTVSMDFDKVFEMGPHLYIGLPGLATDVQTVSQRLKFRLNMYELRENRKIKPKTFMAMVSNLLYERRFGPYFVEPVIAGLDPATFEPYIASMDLIGCPMETNDFVVSGTCSEQMYGMCESLWEPDLEPDDLFETISQALMNAFDRDAVSGWGAVVHVIEKDKVTTKYLKTRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ55</accession>
    <name>A0ABM0JQ55_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101859858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098934.1">
        <property type="nucleotide sequence ID" value="XM_005098877.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859858"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="6"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005098934.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36079" checksum="5B0B0FBCF070ED93" modified="2025-10-08" version="1">MPDKTVYVTRRIPQPGIDKLKEVFEIDHYDSDDAIPHQVLVEALKAKKYDALLCMLTDQIDAEVLDAAGPQLKIVATMSVGFEHINLQECNKRGYLVANTPGVSTDSVAELTCSLLLMTARRLPEGVDAVKNGEWGLWKPMWLCGTQLNNRVLGIYGLGRIGFNVGRRLKPFGFSKIYYTDVHEVSYAKDLDAEFTDFEGLLTKCDFICVCCNLTPQTRHMFNRDTFKKMKNTAILVNSGRGGVINHDDLVDALRSGEIQACGLDVTEPEPLPKEHPLVSMNNCVILPHMGSNTWDSRNAMACIAARNCIAGVSGQTPEGNISTNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQH6</accession>
    <name>A0ABM0JQH6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101855645</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099169.1">
        <property type="nucleotide sequence ID" value="XM_005099112.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855645"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="369"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="369"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099169.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50973" checksum="250E7A2E3A656F34" modified="2025-10-08" version="1">MENEDRAFSETNDMIQQWYFDYFVHTCAKLVDPNGSQDKTSNWEQIERTMSMIQCLLHESVDPEYPGNKIKAHLLELLSLTRNVAIRLESEEQESQTDLLENFREILRSLMYIYENSEAVRSEAEVCLFETNYVICHVAAKLNLTEASPKQLLSKLISEAHRNLRRFRNLEDDVQTAKLNTCNKLRSHPRSISEIEIQPLLASLLQLVKDVEHSLDAPYLIEIAALHKLRTKLKENPGEEEEELLAHDRPESRGDVENVLAEIGYAGNTLNGQRKRKGAEESLCKIRKSFKASKRATRPSDGVDRTQRKRSAPIDDESSPRSGRSSSDSSDDQLSSSDTARRRRPVVLKKIVPRQSLINFARAVKPPSHQTLRMGRWTQEEVDEFILATLTIGEGYWVEIKRAIDSKRSSTQLKDKWKSMPIDRILSVARENDLKYTGKKWHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRP5</accession>
    <name>A0ABM0JRP5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101853857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="6">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005100001.2">
        <property type="nucleotide sequence ID" value="XM_005099944.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853857"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0801">TPQ</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="10">
        <location>
            <begin position="128"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="9">
        <location>
            <begin position="365"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005100001.2"/>
        </source>
    </evidence>
    <sequence length="835" mass="95405" checksum="5C732BE85C2DFCB3" modified="2025-10-08" version="1">MVYRSSRRQAQRDDEPEGFQLQEPSIVMDKGARSRRQVGIWRAAAVLLAIVCIGLSIAVIAMATRGSEGGDGFTTCGRGQNAKSQGIIDRGEPDKPGPFHDLTKHEMRHLRSFLEQDPNIKAVDPDGATMEQSNIYMMDLFPAPKKAVLKYLDKNGPQPPRQARVLMYRGDLRPAVVEEYICGPLPDVRKCELLKSDKRRNPVEFALRPVGLMEFEAIYNYVLTEVDKKIGYILKETYGTSYVNCPPDECFKVYPSPIATKLVDDITKRRLWVWADYPVEYYALHPTDFGVLAVLDGSEPEKFYVDKVWYNGVLYDSMDDLIVKYNGTSPAQRYKLNKPKPAPEATSSLYLRGDPLPKEPQRPPTLVEPDGRRYSLKDRKVEYLGWTFNFRMSALTGPSLFDIRYKGERLAFELGMAEIAVYYSANNPLHRVTDFVDSGALIGSHSKSLVPGGDCPETATFINQTFSGQSTSEPVELARSFCLFENNNGYPLRRHLSYSQAEGAFYGGMMDSALVLRSALTIVNYDYIMDYIFHQNGVVETRVMSTGYILPSFYTSLEDPYGFEIEDKLLGNIHHHIFHFKADLDIMGTSNRYETLDIVPEAVDMRTVPGRKYHQTKYVRNLRKNEKEALYKYDFDTPKYHVVHNNAKKTKYNAIKAYRIAMHGMSKQMLPENEDNEGTVPWARHQLVVTKHKDNERVSSSPYAMWDSQNPVTDFTTFYEDNDNIVDEDLVFWITQGMHHIPHTEDIPLTPTVGNHLTFFLLPYNYFDECPSVASRDHIRIEHKNKKDPKQGVRVLRNGNSVDQCSLPPVAKEYDELLERDPDVILESTEFRGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS38</accession>
    <name>A0ABM0JS38_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Latent-transforming growth factor beta-binding protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100258.1">
        <property type="nucleotide sequence ID" value="XM_005100201.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854641"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046568393" evidence="2">
        <location>
            <begin position="26"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="3">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100258.1"/>
        </source>
    </evidence>
    <sequence length="700" mass="76206" checksum="97E6C8CDE90CD190" modified="2025-10-08" version="1">MGTLLPHRVLISLLGCSLLLVAVQALPPPLLSELCAERADDCLSSQECRVVKNCPSSNCGLTPTCLWKYVVKYEFDEVCRSKDYFHALLISDPANQNALEEWKCKGPNKFNDCPHGSVCVDDEEGGGTCCLGKPEYKKPGSCPINDLGACNGQECSRDADCPGEEKCCEGCGKRCIEPVHVERCNKECPVGQRCVLKKPVCKPGTFCIQAFVPTCVPVACEACRPNQECRKVLRKRDCLNPETCQEYRYFCAMKSSGECSADAPCSFGKKCDSQPICVAIEPPVPAPPELFPGQEASVMPGGAPPPPPPVPGAPPAPPPGGFPPPPPPPPPAPPAPPAPPPQRKKRSTQSLLYDPYCSTHSFCVVDNCGGCKEGQICKQTNIECVTKPCDNHVCVEDNECGGCLDGRVCELVYPPCAPPVDCSALLELNPEAECPESNCEPVHACIEPRPVITCANVRCAAGTTCEMIEPPCPTGQPCEPPRPQCIPNCSKECRPGFQCESLQPPCPLPAVCLESESQDCVSPTCPSFERCADVRPNSCDDLKCPGGTECKMITDTCGRGKLCRKMAKAECVPICSLKCRSGRTCQLTSKCPSDGSECTHQQRCVRKPGTCPKKCRPGMECVLRKPRCSRGRMCRARYVCMHIRGTCPRLPSQKPDKNSYICRRERRRYRDCVSDHQCRTNHKCCTSKCDRKICMAEQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTV3</accession>
    <name>A0ABM0JTV3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101852773</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101852773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101355.2">
        <property type="nucleotide sequence ID" value="XM_005101298.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852773"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005101355.2"/>
        </source>
    </evidence>
    <sequence length="258" mass="28617" checksum="E114C567D3FE8D58" modified="2025-10-08" version="1">MIMASLFCDFLGQIPSKDYRKISQKSHSSRRVQMMEQEVVGEPAQTDTELDVSYLEQRKISCLPRCPETERSTVCGHPTVVALSYHKESDTNFRLLVPTSGNSKCQIGRQSSEKTQSGGMDLCGSDVQSRMFGGMRRGGRTYENCPSRFVSGDFAWRNIVISVLLLFTAPLASGQGCERPPFAVNVNETDPPGTVILSLNAPTGVSWTHSFPANKANLSDLLGFDFDPVTQSYQLVVKETIDIDLPEIREKFGNRTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUM8</accession>
    <name>A0ABM0JUM8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC101857656 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101857656</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101893.2">
        <property type="nucleotide sequence ID" value="XM_005101836.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857656"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047434141" evidence="8">
        <location>
            <begin position="21"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="9">
        <location>
            <begin position="164"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="11">
        <location>
            <begin position="480"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="562"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005101893.2"/>
        </source>
    </evidence>
    <sequence length="775" mass="85939" checksum="9463DA29BC0CEFD4" modified="2025-10-08" version="1">MRAFCLTLVLLYSIVVVAASFQVVEMSRGRRPVDLVGGKGLLGGFSYQNYGLLGGTAQKDVDKAAAEAVEAMNNVKSEGHSSNTMPLLLTGVGRNVGTKVVAGIVYDLQLSLNIDGQAKVCHVEVTHLYPWLNEGTWSVKTKTESDPCVEYETPEKTSARRKRSLLGGQEESGVEEMETQKAAMWAVDHINQMSNSLYRHALLHISHVTKQVINGYRYRISLTTVPTSCRNNGKNNHKTLKECPAKDGGKAQNCEVSVIFSLGKYSMESFKCEAAKDMIGGDDHDYKPHGKLLGGDDHDYKPHGKLLGGDDHDYKPHGKLLGGDDHDYKPHGKLLGGDDHDYKPHGKLLGGDDHDYKPHGKLLGGDDHDYKPHGKLLGGDDHDYKPHGKLLGGDDHDYKKHGDDGKESNLLGQDRHDFIPHGSHWNGFMNKIRAHKKPTRGLWLGSGHLQAVQHMSILGGDTHDYVNHGTSECAKYKDEFLKFKATYNRLYEGPEETQRFQVFCENMKKVETIQSMERGTAKYGVTQFADLSEEEFSKQYLGLKPTAPVRQLPMAKIPDGPIPESWDWRKHNAVTPVKNQGSCGSCWAFSTTGNIEGQWAIQKNKLVSLSEQELVDCDKLDEGCNGGLPSNAYEAIMGLGGIETEGEYKYEGRDDKCRFDKSEVAVKLTGAVNISKDEAEIAAWLYHNGPISIGINAFAMQFYWGGIAHPWKFFCNPKSLDHGVLIVGYGVEDNEPYWIIKNSWGPSWGREGYYYVYRGDGTCGLNTMCTSATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUS3</accession>
    <name>A0ABM0JUS3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26B-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101984.1">
        <property type="nucleotide sequence ID" value="XM_005101927.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859025"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101984.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="41365" checksum="9885E7319109E5DC" modified="2025-10-08" version="1">MSFFGFGQSAEIDIVLDGQENRRTAEIKTEDGKKEKYYLYFDGETVSGKVNVTLKKSGSKLEHQGIKIEFIGQIELYYDRGNHHEFTSLVKELARPGDLTQNTSYNFEFSQVEKPYESYTGANVRLRYFLRVTIVKRISDTVKEQDIVVHTLSQYPEMNSSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMELQVIKRETTGTGPNTFNENETIAKYEIMDGAPVRGESIPIRLFLSGYELTPTMRDINKKFSVRYYLNLVLVDEEERRYFKQQEITIFRRADKVRKNYQAALSHHNPSLLSDGSSARAAQQQQQQQQERQQNEEAEEDEKEDENDEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWT2</accession>
    <name>A0ABM0JWT2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101863916</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103388.1">
        <property type="nucleotide sequence ID" value="XM_005103331.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863916"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046136529" evidence="1">
        <location>
            <begin position="33"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103388.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="29708" checksum="FD0099D0A37DC31D" modified="2025-10-08" version="1">MTSSVLSPTSSFLLVLVLNVMLASIPLSAVTADEFFKQPAESKTTVKRSTSGESKPPRLLELIEMRDAVSSMLPVDDTPSLTRNFDGTSDVGDGLQAGGSQVPRLFKRVFCNGFTGCGGRFRGRRRQLNEALGKRRLSQQRVGKRPFCNTLGCYNGGRKRHEEEEVESGKVEEQLKELVSTSSRLPVLSPRGGWNLDEKVKRLFCNGYGGCQNGGKRWGKSGMGTKQTGASSRNLALPLSDESLKKLSTMKRFFAGGYDNDMEGLIDSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWW0</accession>
    <name>A0ABM0JWW0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101856038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005103442.1">
        <property type="nucleotide sequence ID" value="XM_005103385.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005103443.1">
        <property type="nucleotide sequence ID" value="XM_005103386.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856038"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058738">
        <property type="entry name" value="PH-like_AREL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF340">
        <property type="entry name" value="APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25916">
        <property type="entry name" value="AREL1_PH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="236"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="629"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005103442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005103443.1"/>
        </source>
    </evidence>
    <sequence length="962" mass="109194" checksum="AFDDD5C327386BFF" modified="2025-10-08" version="1">MEESERTKVTFLLAIALLSSGALLFLRHQGSVLEIAEVDAWLESNRLSYIKDVVHQAGGTSIHGALQVVRTIQKTRRLHRSLTKEQHTLLDKAVRRLNDQLELELWLQQHDLTYCFQVLMTNNVISLKDLAKHQDKEVRDLLTVAGFHADFSHVLSDSLFELREDFKQNHKPVETKALSQFVKAKGESKMLLILITFFLIILVTSLTMLLSGMHVPSACYHALPASKSSIYEYLTGRYSSPHNSRVTWDWTDPSTVGKTMTFGVRFFQKNGTPYPVSDGDGVLIEIVHEGVKVAQTLEFSGDEPADMNLVRCSFTVHKSGEYKISVMVGGRHIKDSPFIKCFEAGPIDPSKTGFMHYTSTVVFPAGTSYPLVMETRDSFGNLSAYRADHKAFFKIKVTEAGTGERYSPTTQIVYNTLEKKLVMHIKMDKEGCYQATVSYGDVKLKNGEFDILVLSVSELSKVHKNVAKRKHNLWYEARLLTQNGETLDKPKKVYVYVSPKQLTIKEYYFKIYPKKLCTFRVCPWTKFVFNGSNNNYDAPRFSIEDGSQPSVELSARERNTIIATFSCFLLKSIGGSETFNDKRNFFYQEIRATHHRRSHSSLVVKVDRSSLLYSSYRATKHLNLCDWCKRFEIVFVGEQGLDWGGVSREWFEVLAKELFDPNCSQLFARLTDNPQGLVHPNPKRPPDKKIKHYEFAGKIVGKCLYESSVGRTQLVKARFTRSFLAQLIGLRVTYKHFITDDPEFFTTKISYIENNDVEDMELTFSEEIYNAQGQLVKVIDLIPNGSKVPVTNANKLRYLDALAQYRLVAPVKEEVEGFLRGLSSELIPENLLSIFDENELELLMCGTGTYSIADFKLHHNVVGASPSFNKVRGWFWTIIASFTEEQMARLLQFITGCSQLPPGGFSELNPKIQLSSAPTYNNLPSSHTCFNQLCLPDYDSMDTFHKMLLIAITEGNQGFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXR3</accession>
    <name>A0ABM0JXR3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101851138</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104004.1">
        <property type="nucleotide sequence ID" value="XM_005103947.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104005.1">
        <property type="nucleotide sequence ID" value="XM_005103948.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851138"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005104004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005104005.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="55666" checksum="59D5B42BE99EEB56" modified="2025-10-08" version="1">MYELMMKDVRSAFATGKTRTYEWRISQLKAIMRCLQENSDKINEVLFKDLHKHSLESVVMEANMCVSEAIDCINNLKDWMKPEKVSKPALYMMDTAYIQSEPYGVALIIGAWNYPIQLTLLPLIGAIAAGNCVVLKPSEVSAASAQFLQDYLPKYVDNDCIKVVNGAVPETTALLKEKFDFIMYTGNSFVARIVMEAASKHLTPVLLELGGKSPAYVDKGTDMEVVARRLCWGKFANAGQTCVAPDYVMCQKDMQDELIKNLKATIEAFYTADPKSSDSFGRIVNEKHFQRVQKLKKGAEVAVGGGDVEEEKYIAPTVLRDVKLTDPVMQDEIFGPLLPIMPVQDHAEAIKIINDRDKPLSLYVFSNNKSLIQEFRLGTSSGAFLVNDTVVHGGLNTLPFGGVGNSGMGRYHGKHSFDSFSHQKAVLEKSLALDSVNQLRYPPYSDTKLGWLQWIMKKKVKRTGVFSFLPFVVMGAMFAMFYKTAGVMADSVGAGQDNGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXV4</accession>
    <name>A0ABM0JXV4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c oxidase subunit NDUFA4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101853336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104101.1">
        <property type="nucleotide sequence ID" value="XM_005104044.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853336"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256:SF1">
        <property type="entry name" value="GEO09626P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005104101.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9784" checksum="9DCF84C745B2BE9C" modified="2025-10-08" version="1">MPMAGLTMASLKKHPSLVPLFVCVGGGMAWAAYYIGRLSLRSPDVGWSQKHEGMANTRWPVNKQYKFYSPIRDYSKLENPKERPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY91</accession>
    <name>A0ABM0JY91_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Retinol dehydrogenase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104381.2">
        <property type="nucleotide sequence ID" value="XM_005104324.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857269"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF3">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="81"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="382"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005104381.2"/>
        </source>
    </evidence>
    <sequence length="445" mass="47921" checksum="A52F56CDDA659A0F" modified="2025-10-08" version="1">MVELCAAVTGVYLGWVLLAVFPRKVVRLSWRIGQDLCVLAACSAILPWLLRHETVSAILVGVVGFLLYQDLPAPHLPAASKTVLITGCDTGLGHALALHLDQLGFTVFAGVLDDQGAGATSLACDASGRLVIVPLDITDTAQVKAAAGLVEQRLAGTELHGVVNNAGVLLLGAVEVMSAADARRIIDVNLQGLINVSRAFLPLLRRRRRTAARLVNVSSNVGLAPASQMGVYAASKAAVAMLTETWRYELRPMGIYVSMIVPSGFRTGIMAYDMERVAERWWSEASPEVKDYYGRDCFLPVNRTKNYKEYLNPDFSPLLSCMTDALLSRHPRPVYYKGLLARLLPCLYAHLSPALWTHAMALLADYHHFPVRALRQRDAPDSDSSSPSSSSSSSPSFSSSSSSMSNSFFSSPSSSASSDVRGNNHDHTHNGHNKSPTSAAAAKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYI6</accession>
    <name>A0ABM0JYI6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Transmembrane protein 144 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101853477</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104534.1">
        <property type="nucleotide sequence ID" value="XM_005104477.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104536.1">
        <property type="nucleotide sequence ID" value="XM_005104479.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853477"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005104534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005104536.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="43503" checksum="B1BC18CC50C8A68F" modified="2025-10-08" version="1">MEWINVVNTTVAPHNTTTPLPQSHSYPDYVGYICSLIAVLMYGSNFVPVKKFVTGDGMFFQYVLCSGIFLVGIVVQLVQNSTFYPLVMLGGFIWATGNLCVVPVFKTIGMGLGMSIWGTFALVAGWASGKFGWFGNKDDVISNPAMNYGGVGLAFGSILLYVMVKNEVSGSTEMEIIVTEEETSPLISGPQSSINESQRSTPASRNGDDVLVFNKLANDAKKSGNGNGNDEDDEQDDRMWIEDLSPMLKRIIGTGLSIFSGFMYGINFTPAIHVQDNVQGASKNGLDYVFAHFCGIYMSSSIYFYIYCAVKKNKPKVYPKVILPGIVSGIMWGIATASWYIANATLSESVTFPIISTAPAAIASLFWGVVVFHEIKGKRNILILIAAFCIMSGGAVLAGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZW3</accession>
    <name>A0ABM0JZW3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Gelsolin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC101846677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105454.1">
        <property type="nucleotide sequence ID" value="XM_005105397.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105455.1">
        <property type="nucleotide sequence ID" value="XM_005105398.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105456.1">
        <property type="nucleotide sequence ID" value="XM_005105399.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105458.1">
        <property type="nucleotide sequence ID" value="XM_005105401.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846677"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="187"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="287"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005105456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005105458.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41030" checksum="7A967246EE5DCBEA" modified="2025-10-08" version="1">MSGLVKAKKYDWKDSNLALFGSDTEKEVKKESAEQEPAWQGAGAEPGLKIWRIVDFKVTEWPEDDYGEFYNGDSYIILNTYKDEETENLLHDVHFWIGKNSSQDEYGTAAYKTVELDTFLDDVPIQHREVQGHESALFRSYFEDGITLKEGGAASGFRHVPAEEYTARLFRYARDKHSHIVLTQLPRAASLVTEGDVFILDCGLKIYQYNGDDSSPMERSKAMQYVSKLKSQRGEADSDVLDGSSTSKSHEFWEKLDEEEGDSLSDDEDGPESQTLLKVNTETKDSEVVKEGDLTKDDLAADDVFIVDSGDVVFVWVGENASSAEKKNGIPYAHNYLRESGQPWRPITVVKQGQKCPQFESAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K140</accession>
    <name>A0ABM0K140_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Short-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106286.1">
        <property type="nucleotide sequence ID" value="XM_005106229.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860118"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="45"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="160"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="267"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005106286.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="45477" checksum="5BB814ECC3B90472" modified="2025-10-08" version="1">MAKPLGLLRHCVRSLQKVQLVSGQNHGQLGQQHVRCASSLIDLPETHELLRKTCRDFADNELIPVAAQLDRDHMFPKEQVRQMGELGLMCMDVPESDGGTGLDYLAYAIAMEEISRGCASTGCIMSVNNSLYLGPILKNATAAQKEKFMTPFLSGEQVGCFALSEPGNGSDAGAASTTAQLQSGQWVLNGTKAWITNGYEAGATVVFATTDKSKKHKGISAFLVPKPMEGLSLGKKEDKLGINATSTCYLIFEDCAIPEDYLLGQPGMGFKIAMQTLDAGRIGIAAQGLGIAQAALDCAVDYALKRNSFGVPIAKMQTVQMKIADMETRLESARLLTWKAAMLKDAGRNFTKEAAMAKLAASETATFNAHNAIQILGGMGFVKDMPAERHYRDARITEIYEGTSDIQRIVIATNIFKEHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K283</accession>
    <name>A0ABM0K283_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101847064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107015.1">
        <property type="nucleotide sequence ID" value="XM_005106958.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847064"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005107015.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14796" checksum="2CF27D2D3F4D346D" modified="2025-10-08" version="1">MTESEKDIAVNEFEDDDNEEDIPLEKRKKIFSKELRCMMYGFGDDQNPYTESVDLLEDLVIEYITQMTRKAMEIGKSGRIIVEDIIFLIRKDPKKYSRVKELLLMSEELRKARKAFDEIKYATTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K371</accession>
    <name>A0ABM0K371_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylgalactosamine-6-sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101852121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107712.1">
        <property type="nucleotide sequence ID" value="XM_005107655.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852121"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF47">
        <property type="entry name" value="N-ACETYLGALACTOSAMINE-6-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047241704" evidence="6">
        <location>
            <begin position="23"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005107712.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="58824" checksum="772894B6CA9AEE84" modified="2025-10-08" version="1">MFSVRFALLFCALSYFPLAARSDIARSSTQQSPKSAGKPNFIVMLMDDMGWGDLGVNGEPSKETPNVDKMAAEGMLFPDFYSANPLCSPSRAALLSGRLPIRNGFYSTNERGRNAYTPQDIVGGIPDYEILLPELLQKNGYRSKIIGKWHLGQQPRYHPLRHGFDEWFGSTNCHFGPFNNKNTPNIPVFKDADMVGRYYEDFPINRQTGEANITQIFINEATSFIEKQAAAGQPFFLYWAVDATHGPVYASPDFLGTSRRGLYGDAVRELDSGVGRILQLLEKLQVDNNTFVFFSSDNGAATYDKAKGGSNGPFLCGKETTFEGGMREPAVAWWPGVVQGGQVSRQTGNLMDLFSTLLDFANIPAPSDRTIDGISLRPALLSNNITDRPIFLYRGDLLMAARVGQYKAHLWTWTNSWTEFQHGTDFCPGQDIKGVTTHKQTNQTASPLLFDLGSDPQEKYVIPPSSLIYKQQMPAILKAVKEHLATLKPGDPQLNWCDPAVMNWAPPGCEKLGRCLPVPKSQPTKCVWVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K375</accession>
    <name>A0ABM0K375_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Divergent protein kinase domain 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101854528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIPK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107722.1">
        <property type="nucleotide sequence ID" value="XM_005107665.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854528"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029244">
        <property type="entry name" value="FAM69_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14875">
        <property type="entry name" value="PIP49_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005107722.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="47672" checksum="C99442509B4F8E04" modified="2025-10-08" version="1">MKLRLRLKWKYALRQFLARCLAYFLLGATLCQRYIYAVLCVCGVSLLLLWASYESTSCRTLNLPDSLCAEYARKDVAGTLCEDVCQTITIDTDGCVDTSQRLLILQKGMNRLVMTDTLGHPHALLEEGYSVQQFLERLRAFVRHELGEGDHSVLIKRLFKEFDRSGDGMLQLGEAQSLWRLLRQPYFLSFFIFQDSPSVPYLNGTCGQLTVWHEPYNRARHVLYRRASPWPLSMFSDTAYRWTLPSWMRRAKVVMSLLELVEEMYEKEGVRYHLCHMDGLTLHMHPKDFEVLISHNAMLLSARQVQNRLSNMTCRRHSDCYLTEQCQTSCDYQTGRCTDSLVRPTLSFVCEIMEEYLLFDTPKQIKANLTRLIRRCVLLGRRSASIVTHSVLLIDLKNVIWNFIQYAVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K388</accession>
    <name>A0ABM0K388_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101858301 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107739.1">
        <property type="nucleotide sequence ID" value="XM_005107682.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858301"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005107739.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46684" checksum="26534CA3D2EFDF4E" modified="2025-10-08" version="1">MNGMRPDAAGALWKDQLLEAAETDSVCDIQRLLQTPIKVTKELQDDSIEAVYLALKKGKWKVLLEILTSRIFKEKHKQRLLTEFPNLLYYTVSLCEDYKKVVRRMCHTLALPDTTVSEIFGLLNEDGFSALHLAAIDGDVDSARRILALGGSGYIPSQDGNTALSLSIAFNHPHFWKFVLPFSNVNTCDNDCDTPLMFACWRRQHKLVNALIQSGADCNARSKLHTSALWNAVYKCSYHCVRILLESGADMTVRCEGTYLFLNEESDGGEEGSIKQIYPGAFRSLLWVCVDRCGQRQNRSRSSCLQILSLLLAAGYDPTQDHWIKKLASFHRPERPLNVSKPAHCLPFNVVNDSGLINLLMYVYAQPLQLRSLCRNKIRLLFVENKTTLSFKKWVSALKVGVNTSQFLTLQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3W4</accession>
    <name>A0ABM0K3W4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101860603</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108164.1">
        <property type="nucleotide sequence ID" value="XM_005108107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860603"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005108164.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39773" checksum="959722CC09F17D6A" modified="2025-10-08" version="1">MTSSSIILGNDAFDIIQPIVVYGLSFPISVIGLVFNVINTAVFLKIGVNDSVSVSLVALFVADFVFLLLQAYRPIAQMLMKLGLTHTWSVHPTQIATFASSYISIFYLISTLLTTYIALARCLCVALAFRFQRIFTVNQARIVVVSVYIGALLSHIPPILSQRLVWRSKVNTPKAILVVERVDHDTFESFSKLHNIVNRTLLPYSCLAICILCLIVLTVKLRSVSQFRANATRSASKPDPRLSHGKHELDNNAEKEQITSSSPSALSIKEIQLIKAVFLLCAIFVCSASLRAALGIAVVWMPQLETEPRYRSLYAICMEIIGAFMVVNCAVNFIIFYHYNTSFRQTLTSLTKRSVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K466</accession>
    <name>A0ABM0K466_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2',3'-cyclic-nucleotide 3'-phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20 21 22" type="primary">LOC101860845</name>
    </gene>
    <organism evidence="18 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20 21" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates. May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14489"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:66954"/>
            <dbReference type="ChEBI" id="CHEBI:78552"/>
            <dbReference type="EC" id="3.1.4.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Exists as monomers and homodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2H phosphoesterase superfamily. CNPase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.37" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005108340.1">
        <property type="nucleotide sequence ID" value="XM_005108283.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108341.1">
        <property type="nucleotide sequence ID" value="XM_005108284.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108342.1">
        <property type="nucleotide sequence ID" value="XM_005108285.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108343.1">
        <property type="nucleotide sequence ID" value="XM_005108286.3"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNPase"/>
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    </dbReference>
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        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10156">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10156:SF0">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0636">Prenylation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Cyclic nucleotide phosphodiesterase catalytic" evidence="17">
        <location>
            <begin position="254"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide phosphodiesterase catalytic" evidence="17">
        <location>
            <begin position="504"/>
            <end position="578"/>
        </location>
    </feature>
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        <location>
            <begin position="410"/>
            <end position="489"/>
        </location>
    </feature>
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        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
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        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000610"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023289"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF05881"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005108340.1"/>
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    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005108341.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_005108342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_005108343.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="64364" checksum="3A5D101224EB8846" modified="2025-10-08" version="1">MDAAFTVSTVPVLTSSSLDLKCAESKTQDGKCLQELVLGLTELGLELNIPASAATDEVREHFSQTRVAQSQRLPVEPEPIDTSTAIPPGANINFLNFPFITNRETVRYVNNSDSRVMFVLRGVSGSGKSTVVCTIKNLYATRAVVCSADNFFLTEDGEYEFDEKLLSSAHSTCQQKVKEACHKGTPVVIVDNTNVKKWEMKFYLSLANRCGYVVILVEPKTPWKKNARELHKRNKHGVPLEVLQRKVNSFDDIIPSYYGWFLNGKMSQKLSRFCSSLFMECQEKFPALKRDLLQELHVQPSLIDEETAQGILTEYFSHAAQSSPLLHCTSRFCARGKVPGSTTYHNRRDVQAACGKSFCLTITAVVITRRTLSIRVSLGENQMPLFDRPEERDWAKGARGFYSNTSVLPAGSSNCHEGEDEGDGFSVVRRGKKKGRLAKQTKRKTKQSPRKEEQDESNRGENLESGDPFVSEATSEGDTSADMSDLSEGGGLAEIFPHAQFSGTGRSCHCTVKTARGIESRETNFDILQLCDIERSQLHQLSDFIDVKHGKAKYYGDGFCCVYFTKPLKVGSLFSGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K700</accession>
    <name>A0ABM0K700_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lamina-associated polypeptide 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101859205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110206.1">
        <property type="nucleotide sequence ID" value="XM_005110149.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859205"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12940">
        <property type="entry name" value="LEM_LAP2_LEMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051656">
        <property type="entry name" value="LEM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12019">
        <property type="entry name" value="LAMINA-ASSOCIATED POLYPEPTIDE THYMOPOIETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12019:SF9">
        <property type="entry name" value="THYMOPOIETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="LEM" evidence="3">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005110206.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21418" checksum="40F0B2157A664B72" modified="2025-10-08" version="1">MPLTNQIDYSSLSDEELTQMLVDYGIDVGPINVATRGTYERKLFKLKTGEASPPTQNFEPVPDDDEEDEEVELKLPSTSTRSTPSASARMTSPSSIPVPTQTRFRREIFDQSTPIIDSRPSLSATRRTPTETLSSRPSGGRPLPVKVEQESKGVPLVVKLIALAVVVVLIYLIYTNMEPQAISNIPSIQNKMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7G7</accession>
    <name>A0ABM0K7G7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101849416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005110572.1">
        <property type="nucleotide sequence ID" value="XM_005110515.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849416"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18051">
        <property type="entry name" value="DEADc_DDX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="317"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="519"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005110572.1"/>
        </source>
    </evidence>
    <sequence length="781" mass="84501" checksum="F1F65E8E281D95D6" modified="2025-10-08" version="1">MPNGSNQNGPGLEQQFAGMDINGPGRNQNFDQGNFGGGRYVPPHLRGGGMPNLSQPPPGHPNANLPQENWSNSGGRGPMPRDGGRWSGNGRGGSYGDRSGGYGGDRGGSGGGYNDRGSYNSDRGGSYNDRGGYGGRGGYGGGRGGYDRDGRGGYDNRGGYDRRGGGNPGGYGRGGGGYQYNDSRGNDRWNRQGSAPPPPGGGRWDGLLEDRDRERRMGGQGYNRWDNRMDGGGEDNSRQEDWSIPLPRNERLEHELFGGGNTGINFDKYEDIPVEASGDSAPANIENFEDCSLGEIVRNNIALSKYAKPTPVQKFAIPIILGQRDLMACAQTGSGKTAAFLVPILNQIYTMGPGDASNQPGGRQYGRRKMFPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGAQMRDLDKGCHLLVATPGRLVDMMERGKVGLDLCKFLVLDEADRMLDMGFEPQIRRIVEKDNMPPCGKRQTNMFSATFPKEIQVLARDFLDNYIFLAVGRVGSTSENITQKVVWVEEQEKRSFLLDLLSAAGGGGAGAPSPESLTLVFVETKKGADALEDFLLRENYPATSIHGDRSQREREDALRLFKFGERPVLVATAVAARGLDIPNVRHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNDKNKNIVRDLLDLLGEANQEVPAWLESMSMDVRSMGMGGGRRGGARRFGGSGFGGRDYRQNKPLKTSFNQGGGGGGGGGGFNGQQAYNNHFTNYPPPQYNNYGGSYGNSYSSGSANDWWGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9I0</accession>
    <name>A0ABM0K9I0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0764 protein C16orf89 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112111.3">
        <property type="nucleotide sequence ID" value="XM_005112054.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864578"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031751">
        <property type="entry name" value="DUF4735"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539:SF1">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15882">
        <property type="entry name" value="DUF4735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046686235" evidence="2">
        <location>
            <begin position="26"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112111.3"/>
        </source>
    </evidence>
    <sequence length="383" mass="42392" checksum="F5D02460E862C383" modified="2025-10-08" version="1">MDSRWSLALWTLLFTSLTLPGAVTSHPQDGGGVRSQRGDARLLQDVLRGLEKAANFFREDFSSINVDGLFGIRVAQGTIIQSLNFCVSGTSPRCSPELYARLGSLNTTIGTMADRALPYIKAQDPDYYQSFYKTIDGPYMIAESSQSLGRAVSAPGVGTDYNEESGDRCLASLMGTWRRDGRTVPVCTVDQECLQMMTRPHQASYSITHQLLYFIMAEKNGCLDELDSLLSAEGLGSVKEFEQSLCGHIYSEMEGEVNDGHVAQLQQDLFLEQNVLCGVIGFSDFFPRSWISMVLGWQTSRGCFSMAGSLVALQAEIQSVSDQQRELLQRLEEEARDSDSAPWTSRKLMRERVMEDDCLAHKTGLGIGVLGVYQRHLLENTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA94</accession>
    <name>A0ABM0KA94_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC101862921 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101862921</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112687.1">
        <property type="nucleotide sequence ID" value="XM_005112630.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862921"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="116"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="725"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="838"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="868"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="896"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="395"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="913"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1138"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="967"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005112687.1"/>
        </source>
    </evidence>
    <sequence length="1236" mass="138275" checksum="FDE3233772AE7743" modified="2025-10-08" version="1">MIDEQNRQHVALRKPARPAGGGHVTVPVHHVWPGEHIKIQPPFPDRTVKNIKFWQRLSHICETDVATERLWNNSTLCLFYFHSLRMQSDILPLCDSPPHSFLINKLCALKESEEFCDLVFELSGARYNAHRLVLVVWSPVMRNMLDPRVATTQHVRVLCDQHDAFQSFLNFLYSGVLEEAMSNISTLLLLASTFQVHILRSMCETYLIRTTTVDNVISHFHLAVKFQLSDLESGCVRFLGENLDDAVQKSDFRDLAPEQFNAFLGSHHVSRLNPEMKLFLIISWLRGDVPKRQQYLVLLLGHLDWEVVAKDFLLEISQTENFFTSNPSSLYLLLQTLHSAAITLGPYTDQFEALREQYSYLLSSVVTSIVDLGSGRHKVFHPVSLSVISNSPTLQAADSAHSRQPQVSADVDQPDQKTSKSRKKKVPISVTESPECVSESPHEPSKDNTDSPDVSGRDEKGDTLGEPALRAHRSRGSMKRKLKLPRRLISTEEQTEKEEEKASSSRQAKKRKSELVQSNQRSTEKAVSKEVSKSPPDQEILRSNTRSARSGDLSSSSDGKGKGSKTITTKADPIAPRMSTRVREQRKEVTTESVEVTSDETRTVSLRASGRPQRGQTKVVPSKAYEESKKGGKAVEASSAKLKSQELSQEDSSSTKKLTKDEPPRTLKCSTCSFSCNTKVELDKHKKKAHESKGTFRCPLCDFVCKWNKEFNEHLKSQHFQGPPYLCDGEDCHFSTDKMATLLTHRRQHTDDRPYVCSSCLMAFRTRNNLYAHIKNHSDEKKYQCPECSRTFKLKNTLDQHMVTHSDLRPYLCDLCGFSTKFQSHLIAHKKIHTGDVFRCNFPSCKYATPKRSQLEAHMRSHLGIREHVCKVCSKAFIERSHLVRHERTHSAVRAHKCDVCEYASSRVDKLREHVKKHHSGETEGSVELATTSAQGKGKKKKGSGAAEDKTDSFSAQSSAIVETSKDTPTTLTDTPTSLADTPTTLTDTRQGPGASSAPVVSVRHEESKKRGADSGYKKGVEDCGSAYRVGVESQQYSNRHRVVLENTAHVAGGRRLEESLEPHRLERDMTAEEFFIRMGLNLNDIHSSGSSSVLSDPRGEVISVSLANVHTAAQAEVTQVSQYEPREADCHAAIHQLSSPQAPPPQQTLLLPSSRLPPPPPPHGSVMTFAPPPSIPSSSHLHHVPHPQPVLVIPAGSTMATAEHSVYQPQPQPQPQHDHMADFSHLGTFQFQEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAA2</accession>
    <name>A0ABM0KAA2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase NIM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112699.1">
        <property type="nucleotide sequence ID" value="XM_005112642.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846625"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14075">
        <property type="entry name" value="STKc_NIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049571">
        <property type="entry name" value="NIM1K_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF49">
        <property type="entry name" value="NIM1 SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005112699.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48259" checksum="74B1333EF62B022E" modified="2025-10-08" version="1">MTRLHRSSTEASVGGASEDGGLAFQSRVTPYERLSQDLSNDPRVMKEITLGRRIAFYRVRGEIGTGNFSQVKLGIHALTKEKVAIKILDKTKLDQKTQRLLSREITSMERLHHPNIIRLYEVVETLAKLHIVMEYAGGGELFNKISSEGRLPEPDAKCVFAQLVAAIEHMHDNNIIHRDLKAENVFYASANRVMIGDFGFSTIARSHETLNTFCGSPPYAAPELFKDEHYYGVFVDIWALGILLYFIVTGLMPFRAETVAKLKKCILDGSYTVPSYVSDSCVFLIRSILKHIPQDRFTLAEIKRSEWLEGQEFPESLEPYNLNPRLDSHSLSLEEREARGVLSNLGINDDHMKQSSIRDSRSSITGTYRIVLHRIQKKNSGIQEMTPDPGQESSRESNISMKRRSRRSTPLSKLGSTKQQSKTCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAJ0</accession>
    <name>A0ABM0KAJ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EARP and GARP complex-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101864436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIPR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112897.1">
        <property type="nucleotide sequence ID" value="XM_005112840.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864436"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040323">
        <property type="entry name" value="EIPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205:SF15">
        <property type="entry name" value="EARP AND GARP COMPLEX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205">
        <property type="entry name" value="WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="6">
        <location>
            <begin position="6"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005112897.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43163" checksum="D34B21D2898AF459" modified="2025-10-08" version="1">MEDEAPVIYGLEFQARSLCAQAAETDSIRFLVGTQSLGPENQVHYIDFDDENNLINKTVFLHREGEIWNISASTFDSSLFATCYNKTSDNRSELKGALWQLPGGSNPPSPAGEDNSSAHPHLGLLCYLDTEEHADVKSVLWHPSGDSQPVVGLCQDRIVTWDVDTASSAAKVVSSTSIEGRGHPRLTSGKWNPHHNCHQIATANDTSVKGWDLRTMSQVFHIESAHSQLVRDLDFNPNKQYYLVTCGDDCRVKFWDTRKVTEPLKVLSEHSHWVWSVCYNHFHDQLVLTSSSDSRVVLNSVVSLSSEPYGHLVDRDDDDDGDEDSLQDGPQEPPKDGVIATYEEHEDSVYAVGWSSADPWTFASLSYDGRLVINRVPRSEKYKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBB7</accession>
    <name>A0ABM0KBB7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113489.1">
        <property type="nucleotide sequence ID" value="XM_005113432.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855849"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF118">
        <property type="entry name" value="PI-3 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="11"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005113489.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25978" checksum="85215F33DC208B98" modified="2025-10-08" version="1">DDDLAQYLLQLVQALKFETHLCCPLAEFLLRRALKNQHMGHKLFWLLKWSCRISDLRQDMLTLQILQVMDNLWQAEGLDFRMNPYMCMATDLEQGMIEVVSPADTMANIQRWFKKTAFDKRALFEWLKMKHKSPEHLDAAVEEFLMSCAGYCVATYVIGVGDRHNDNIMMKSSGQMFHIDFGHFLGNFKSKFHVKRERVPFVLTSHFVYVITKGDTERGNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUR3</accession>
    <name>A0ABM0ZUR3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106011071</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106011071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934862.1">
        <property type="nucleotide sequence ID" value="XM_013079408.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011071"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050906">
        <property type="entry name" value="Notch_signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044:SF420">
        <property type="entry name" value="DELTA AND NOTCH-LIKE EPIDERMAL GROWTH FACTOR-RELATED RECEPTOR ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044">
        <property type="entry name" value="NOTCH LIGAND FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="752"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012934862.1"/>
        </source>
    </evidence>
    <sequence length="850" mass="92746" checksum="D804D76083A20692" modified="2025-10-08" version="1">MPETSQNMFHPSLYPGKVVNNIVNKQVIIYAILMITTANGQMNDFYRDLQSLFSSSVLDFTTPEPKIFKDPYSFKTSEQQHNLFDGKNGKGLGSSKPTSSSGSETGPSFMDVNSWSSIPTEFFGSAPDAPESRHNAIHQVSSFLGGTHNYTDTNNNGEISVPEPQNEELAPADGQGAGEVFLPLADHSPGSTFVDNPHVLYDWSAPPVSKDTFQYPDEPQPPVQLFSNGESMAKAILEGKVQRWSWNYSMTTFGGEMGDQGVGEKYYGSMTCCQRLPYICGVDGMCVLDKAQCQEFCVCALNPTAPHCLKTIPRIVRTMRMLERKILAKIAKRLNISYTTIALPLPEIFSTTTPARPTTVRPVPQSITIPPPKRRKPARNLSRVASRPSVARTQFWSLFKHATARPSTTTAPADTTEHTTEPIPTAEVPVPVTTDTTVGENSWGEQTAGDLQKKNPHQASVSASTITTETIKQPLVFTRTSKAKTTVLPTTSRTPESTSSSSENTFISSTDSSHRFSPSTTAKTTDRSSTETTISPSTASLKRTRRIGSTNATNPTVQTTTSVNPKTTSATRLLSTNTVQPRILLSTTITNTRRDRQDMTGSTSTQFALNSETFVPSTSPTDIPGKDTSTTVLPTSLASTTEATALTSNSTPQNVARTTALPFTFSNRNRAASTSPNLVDQGKEMELFSWFSSNNLFSTLDAPTAPSTSPGDNTTAATRRDEYYPPCADDCQEQGGTCVLGDDFKPQCVKVNQDACDHFRCFNGDCVSTDGLYSCECHQNWTGIFCDEPCSVDCGQHGYCGRVDENNTIGCICHWNYTGPFCKEEKQVVTIRTGMWEYSSSVLRVLLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV09</accession>
    <name>A0ABM0ZV09_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC101862565</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101862565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935015.1">
        <property type="nucleotide sequence ID" value="XM_013079561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862565"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF506">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="182"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="597"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012935015.1"/>
        </source>
    </evidence>
    <sequence length="815" mass="90426" checksum="AADCD661704A16DC" modified="2025-10-08" version="1">MSKDAIKTGRYTHKKRTQDTMEVRKLQQLSLLDTGTPGNNGSESSETLSTYPATCALDISNKTTSSESGNSVTDGQSCLGSNPTSSPTKTILLPSVSLSPHHDTSSERSPPSSSSTQAGLSESQWSTSSQSWDTAAGAANSPELASLLAGDGNTSSVDVKNTQATKTVPQKQRVAPKVAGPLPPCKVCGEPGAGFHYGVNTCEACKGFFRRSLLRNGDYDCPGNGDCDIETNRRKSCPKCRYLKCLSAGMSKGAIKTGRYTLDKRTQDTLEIKRLKEAADNGVGIERRQSEETSDNSCAALDLSIFHNPSSSSTQSTSSTEHDSPTFSRHISSTDAQTTFGSDVGSSHFENMLNASSSASCGRKQVTHGEISSKSIDFHSPESFFVLSPFSVNDNHKLSTSGGFGEASRNTSKLYSGNTINSVSSRSPSMNNFRNSFNVHGKVSFHHTESTFSKFQSINNFNDHYRGHEKDSFNDDVHDVPQKHSRFNGLDDEHMFCETSHMNNGGKGPSDSRDQLFTFSHQSLESSQSSMSSSCSLDSISLEGPQWLDYEEGELDELINYLVAGHRRIIIDCNGLSDEYLEEKFKECAERCVLQEEIFGPRGQLSRSEAMEFYKATGLDVDGFLRESDECGAQMEEHTRQTVVFMKLIPGFKALGISDQTNLVKACFTDLIFLAFFRGYRQSDWLVVEVEKTYCIHELRRFYDHEFLDHFFHITGQLQKLELPYEIVVMLKTVCMFFPDRVELAHREEVERLHHKLVQCMMLLLRRRFPQTHGQVLARIISVCATMRSLDEECRTSLCGLGEDRPILAEMFRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW16</accession>
    <name>A0ABM0ZW16_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Nork</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012935708.1">
        <property type="nucleotide sequence ID" value="XM_013080254.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100533440"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF620">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR TORSO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045865053" description="receptor protein-tyrosine kinase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="615"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="917"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="966"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012935708.1"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114688" checksum="ABC3D12485E9A6D9" modified="2025-10-08" version="1">MAVRVWKVGAYLMCLVLWELLLVTSAVYATEEVFITYARCRVQCVTQYLPEEKRQDDNACRDTNNYRRGYNRDCYECWDLCKKFAESSALRKHGCDRKIRCGDGCQTACSFLTKKPKAPALTGEWRFPEDVNSDSSNPRELMIEWQAPNLVSGDTDDVTSPTEADYRSEVGPVIYVLATRNFNQPQDGWKIVQQLVSTRVRIDMDAVPFSPEFLLLAVSEAGLMTQIEFKTNSLVQTDLNQPKGAEFRKLLDSDGAGWYVNKYDGVNATLTLSTHVVNTDSGSYSVQRAEVKFHGPDWLREDTAHAYPMYWIFIDCSSAYSFLPDCNLAKDHFAATVTNRGTEEAAYTVDELRFNSIYQLVIHLGEDYRVKTELVLKTSPCQEPDKLKLSHCLDKIEEESRPSAPIRTKEGEDYDPDVLRLFVNVSSMVLPPDSDLVLVNITWSPIVNQSVAFYNVTTFVENYPFNVQQTSTSLSHVLLRLQQNTQYHVQVEALVRPQPGEVPRLLPVVDRLQFNTSEVNLAIYQGPQPLTLGTDHEMGRVNSIIIGVTIVIVLLFLSILLGLLYKKRKSFKDIIVTKATVAKSNSYKSNVGGKSDYSNQLIVFSDEWELDPHSLKFSTLLGQGAFGKVVTGYYEDQKVAIKIVREGAPLSYKEDLVAEINLMKRIGSHPNIVCLIGACTMSEPIALVMEYVPYGNLQNFLKKCRMDGDVRKRCDGPSEITYTVIQDNGSMESGVVTPVDMLSFARQVAMAMEYLAEKKYVHRDLAARNVLIDYNKVVKVCDFGLSRDIFNDNHYKKLTNGKLPLKWMAIESLRDRMFTTQSDVWSFGILLWEIVTMGASPYPNVALADLYYVLSNGYRMDRPSNCSQELYAIMRACWEDESTDRPNFTQLRLMLEDLLIEDRDYLVLEDIDVPLTHSDNSSSPIPGAITDCPDPHSPTSPVSSDSMSGATAAVSGGDLRPYAGRSGPTSTSTSPSQAMLKGVKKVSPRRDNMRINVCIHQKSTDRLIRPSESDSSPSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWF0</accession>
    <name>A0ABM0ZWF0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106011307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935924.1">
        <property type="nucleotide sequence ID" value="XM_013080470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011307"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="358"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="910"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1150"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1152"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1181"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1210"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012935924.1"/>
        </source>
    </evidence>
    <sequence length="1220" mass="136418" checksum="2E44864FD5236A8E" modified="2025-10-08" version="1">MPHFKPPEPFDFSKPHEWPEWRQRMLRYRTATKLSAETGAIQRLQLEATLTLKSAIETARHFELVKGQVSSQRQLGAAVTVDSVRYGQRGYSSPAHPKGRGGRRTGTHSQHRGSHASPSTFSNCGNCGRGHAQNNCPARGKTCRKCGKRNHFATVCRSSSRNVNEITESETPSFFLGAVDRDSDSNVITDVNFGEVSEPPWRVTLNLGGRATSFKIDIGADVSITSKAVYNRLSPRPKLKTTSAVLRSPGGVIRSVGEFIATTQHNNRNFAFRVFVLDDDTDCLLSRDAAVRLGLISRDRIDSANLMFGDVGPKPIRCEPVKIILKEDAQPYSVNVARRIPIPLMGEVKAELDRTEAAGVIEKISAPTDWCAPMVTVRKRSGSVRICTDLKKLNLSVKRERFMLPTIDDILYKLSGSNKFSKLDATSSFWQLALDDDSAKLTTFITPFGRYFYRRLCFGITSAPEIFQRTMQDILAGIDGVECFMDDILLHTDGHEKHDKLKKKVFQRLKERGVKLNKSKCKFEKDEIDFLGHIISGKGVRPDPSKVSAITEMPEPENITDLRRVLGMVNYLGRFVPNLSTVMKPLTDLLNHDAEWAWTPAQSSAFTEVKRLLSSAPTLAFFDYMRKPVTVSADASSYGLGGVLLQEDRGDLQPVAYCSRTLSRAEKNYAQIEKELLAATWTCEKFDRYLIGLPSFTLLTDHKPIVPLINSKELNDTPVRCQRMLMRMMHYSGKAVYTQGKNMTVADSLSRSPVVSTEPEEFGEEIETHVATIQMSWDATDSKLDEIRNKSQQDPAISAAIQYTRSGWPKFIQNVKSEACDLYAVSSELSEVHGLLVRGNRIVIPKAMRGEMLRRIHDGHLGVSKCRERAKSSIWWPGLSSKIREVVSRCDHCQRKRPAQPSEPLNPTALPERPFQMVGADLFNYKGHDYLVLVDYFSRYLEVAYMPDTTSETVVYKLKNIFARFGIPELLVTNNGPQFVSDRFHKFAKGWGFKHTTSSPHFPQSNGGSERAVEEAKKALIQDDPFLALLIYRSTPVSPTGASPAELALGRRLRTTLPTLPSNLNQQVYDRAKIAARDAESKRKYKQAFDRRHGAQNLPELNPGQLVLQKLENDKEWRGPAVVKELCAPRSYIIQSGDRAYCRNRKHLKPYVDPPSMPSSPVATPEPTPMSVLLPPPPAVQPVEPDVTPSSPQPAAAPASPAPITTRSGRVVRRPARYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYS1</accession>
    <name>A0ABM0ZYS1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium/potassium/calcium exchanger 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106011617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937311.1">
        <property type="nucleotide sequence ID" value="XM_013081857.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011617"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF72">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER NCKX30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="152"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012937311.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="33819" checksum="2B17608E9FB420D5" modified="2025-10-08" version="1">MQLQATLQVIVNPENEHGANNNNASRGDQDHNMQIKVISNGKMPQNGVDSPNTQTGTIAGGLTDREQDTGSKVTSRDVNMSIQNSPNRTDNSNSPAAANDAPSLEEEEEPLDMSWPKTARKRITYVLLAPIVVPLWITLPDVRRPERRKYFPVTFIGSILWIGGFSYCMVWWANRTGETIGINDEVMGLTILAAGTSIPDLITSVIVAKKGFGDMAVSSSVGSNIFDITVGLPVPWMLFSAVNSGDPYSVNSDGLLCSIFLLFIMLIAVVVCIAVSGWKMSKILGVSMMALYLVFVTLAVLLEFGTITCPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ29</accession>
    <name>A0ABM0ZZ29_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-galactosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC106011649</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyses the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_012937480.1">
        <property type="nucleotide sequence ID" value="XM_013082026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011649"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="198"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="318"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012937480.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53427" checksum="BDFAAF0A52A35509" modified="2025-10-08" version="1">MRKLGRVTMSFLKRRIMTSIVYSERRKLFLALALVSGLLFLLLHTIIGIRLFSRPGGNTFTWQEADSVLLVPREISSLDLLNTKLRDAANSSRGAAIADIYTDYKNMVQNFGHRKASYDRQYRQWPAQDSGATTRAAELGGGSQGGVSNETLQTVLGGTTPQQQQQQKQATGASNSNGLPSCVDRHDILGGKFKPVMTELSPDALSYLFRDVTVGGTYTPDSCVPKEKTAIIIPFRDRSSHLNILLLNLLPMLKRQKVDFTVFVIDQQLPSIFNRGLLFNVGFLEASKLGPYDCFIFHDVDLVPINDLNFYHCNDGPTHFISGVNKFNYSLLYRDMFGGIVSFKKKQFLEINGASNMYFGWGGEDDDLRVRVVRRGLKIVRKYADIGLYDMIKHGRENSNGKNPVRGGLLKLAGKRQDSEGLSTIRYKVQGVDLLPLYTRVTVTVNMTEVLETAPPYMDKLTKSLLATDANNNNNSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZB6</accession>
    <name>A0ABM0ZZB6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor Sp8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106011691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937630.1">
        <property type="nucleotide sequence ID" value="XM_013082176.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011691"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="549"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="579"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012937630.1"/>
        </source>
    </evidence>
    <sequence length="657" mass="70354" checksum="6BD786E9BFD47889" modified="2025-10-08" version="1">MKRMQAIVSGKKKQCTKLPTPAQKGKKGVGTPPSATPTATQTTPTTHQTTPSSGSANKSPGKDSSAGSKGAGSKLPVGAAASTASIASSADTGTSTITGGSNSSGSSGQRVPSRIPASSPKKSSKDASSATPPGKGRTRQDSESKSKSRGKSDSSNSGKRFLRDRQKSSAPEVSAGRSRHQGTSEDAKGLSGTQKVNSEQRPTKRELFSEGNRKTVVIDGHQHSMDGSPPREVMVEGQGHRKEHVGGERGILVTRHHSDAEVYSGKHAHFRNTPTVPTTGNPPPSITSHAPPKPVPGSSESVYGYHKQVSTGGSTGHLKDSSTYESIAGLGLGGQYLTNYGSVDPQPGPHDPHGVYGRVAARPPSRTSTRSGSDQLYQQGYGSLPRSSRSTTPTADAAMSSYGSLPRGSNASTPTPQSAAAAAAAFYNVNTAHGWAALARKAESDSGFLYNSLDRHQQGRDRNYHHHPHHPHHGAHRLFYGPHQLPGHSPVDPRLHPAHPFLTPPLTPLCGDLSLLERPVPRRCRRCRCPNCLKSSANPSATPTKRRMHVCHYPGCGKEYGKTSHLKAHLRGHAGERPFVCRWLYCQKRFTRSDELQRHLRTHTGEKNFQCNDCGKRFMRSDHLSKHIKTHEVKKEGGGDRREQEAGSSEDGEREGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A041</accession>
    <name>A0ABM1A041_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101859330</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938109.1">
        <property type="nucleotide sequence ID" value="XM_013082655.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859330"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045433252" evidence="1">
        <location>
            <begin position="27"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938109.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="72417" checksum="9AEF72F7E7B4C164" modified="2025-10-08" version="1">MANVVNMTIATALLCLVFSLASRSDALPHNPEDARTLVQTLFEKIAEEQVQTDIPFKPFKHFGKKKGAYNSEVKLNFHGNLEMAEIRRMLNVFDNNMFVTAWVTSSLLEASRHEDAPVPSDHQLDLALKFMSTNHDQNKPYNTSVMTFWQQVYNASTKCYQSTPTNLIGAIEMTYGMPIEEIEKILERLGFKQLAKDIESILEERETFARAFHIPPDFDDTFVNLGLGSLLYQMKDTIPGAWEIWSSQNTNISSVFTALKKYAYRPFSGDRSVNTIDTRTYFWIRGFLDEASAAKQDVALVSTWVQDLSEVRTLFYKGVAMPFQVNNVDATVAANTVYGITSSVLSGLVSKQVLDDPGVEQIYLNTTSLITYALKNNMINRPDLVLTYYPSQREFDWFVSRTFSEIVTARKKGPLPHSALETVYQMLRGALQEEMTHDILAKAQTGGAEEFYFDDFLGDGDLTHDNRTLVRGEDRIFTTAMAANALLYTWTEYNDKTGKCQWADVPENVRETIAGCINWLTHHTLDGNYDPWNAFFSGSAKGFSSLPFWYPANRFEYLNGTAIHDRSNIPNSTFVLAMEGHVSPQTYEQMVKQTHFGMPTPVTFRGYNYGDGYFPLWSSVPYTYSTTMLALARYNSIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1Z5</accession>
    <name>A0ABM1A1Z5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101856517</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101856517</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100612.1">
        <property type="nucleotide sequence ID" value="XM_005100555.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939197.1">
        <property type="nucleotide sequence ID" value="XM_013083743.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856517"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939197.1"/>
        </source>
    </evidence>
    <sequence length="1219" mass="129679" checksum="7D96AFF6186029B4" modified="2025-10-08" version="1">MMKPETEDPDLAAIHGEASDETSLISRLVQSADGHDYVVNVVVPEGESDSIESETTLAVGDVQSPHPVNQPEVAAQPVMLVRSVAEAQPVVKEEPSDIEWCGQTDAVETVIETAEEMVKEEPIFPVTWGLNIPTVEQTDPHPVCMVQSRKEKVRQPFKLAVAYKKQRKKSKKAELFTKVRKIYPKVQATFQEDTESISTEDFDCSQPSTESEIKDRIKRKTPLDVSHCLVCSATCFLTKNRKIPTLPLCKKCKKAYFYQMARMMMGKFPKVCSKGGNCRVDFRSPVQCPSCRLMAFQQTIAREQEAHYAQSDVVGTSTSKKARGKRRSSGMSEESGSCSSSSYECIPPTKRAMLILHAATSHPVVKLKRLSEECLESYGVALPDPCDEGKFDCDEDIKLNVYFERPVKSEPFSSTFWGQQTSSDDNQYGSPVKTRTPKTSGSVSINKGCSQKKTDKQTQKRKKTAPRSNGRVARKKASEVVKVYVFGCGHACSVCNSGSAQEWLSQSGYHSASPVVPSLGQGLLQVQEDSSVQGGRRMPYIMKPRPSVLPIHASNPMEEPSAVPNSKAQKPTLVPPSMWSQARQKLPHVSVSMSGDNPKCIDPAPLTQPPHISCSSAASVSLQQQTFKGGVSMVRLPSLGNESTSMMTTYREALQKHLDKASVLPVYKPIPALSVSLGYVGTLDKAAVVSTIPIPPVKALESKPSTSMVTRPAVMKTVSNRFRKSIPHAGQNVTTRTSQADLEHASLCNSHSSASSPLNSPVTLLSPSSVIKPGNNATVMPQLGSGVLQIPSIVNVSNQNISVDNGESSGGKYVPLLTSTGSLVLVPADGNNSPSVVNLTIPAVVGQPVPSTSTAQTEANLTGIRNVSNSVPVTAVASQRTPVPVIGCGTPLKDPGVTFKSAIAKSNPTIASAISNPIVGSKLTCVTPQTSGKNTHPHSENTLDLKKNAAVKILNSEIRVPDALSTSTGPPADHLVSAEPIAIKTNLISSVGSGRVSIDPKVSSESVDRCVPSMTTSFNQQRGDAVSGSTVVSIQPTMALVDSATAQADLTSSGTSMVTASLQAGGGIPSFISVQATTAVDNKTSKVDPNTRGTYIHTVTPQVNPMTSADTASSQLDPAVTSAKCMISNLGKMTRSKVLSAMDHSVQPVTLSEAVTTTSLLTSVPSARPVGCYHSKTPASCATSRDGLSPPQASSSTLAKLAARVASTAHCSSEQMSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A211</accession>
    <name>A0ABM1A211_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polycystin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106012061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012939226.2">
        <property type="nucleotide sequence ID" value="XM_013083772.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012061"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730:SF4">
        <property type="entry name" value="POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730">
        <property type="entry name" value="POLYCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PKD" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="6">
        <location>
            <begin position="106"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="6">
        <location>
            <begin position="280"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939226.2"/>
        </source>
    </evidence>
    <sequence length="653" mass="70629" checksum="6E2BDDB1E68D4758" modified="2025-10-08" version="1">MTTTTTMVISHILRKRINIYCSQTGNSVLYNWTISDGFEDLMSTNQNLVHTFTTPGTYYVNATVYNAVSSKNNVTEVFVQDPVTGLSVTALPKVLGTNSDFATTLSTGSDYNCSWNFDDATPTEYTSEVSGTTLGASSYAHMYSAGGSYNVTVNCSNGVSSEAVSVMAVVQELITNLRMVKEGASKNTDYYLEWTVDAGTEITFNLTFDGSLIPTYTTVSKYKWRSPLQPARGASSIPLTLSAANEVGSDSISINFEILSVIVDPTLTTPEFNVSSHTPVPFTVDMAGGSGVTVHFDFGDGQTDVFTQTPGQEWSTPHTASHSFTAGGRFNVLASFSNAEGTYNLTTEVMVLVSVESIACNTSQYALYYPPANASLTLFGTTLPTEPTFTLNWGEPQSRDTTPELVLNTPYWHTFGDTGEFEVTVELANLMGEKTCKNTITVVEKLEGPSFKPEFAKAAVGLPYDVTFCLYRGPSGALCKLDYNFGDGNTKQTDRQANVAREGMDGCDIEPVVYNDYTTRNVMVNAKTPLETDTASTMIEVIDGVSDADIALPDPNDVSFGSPSQFELTYNGAIMPTDAQILVDYGDGTFLGPIPFSVATQGGTQTFSHTYSSDGLFEAVVTIYNDATRVNRTIMVGSYKQFSNLAADMFYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A248</accession>
    <name>A0ABM1A248_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Hyphal wall protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101851271</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100759.1">
        <property type="nucleotide sequence ID" value="XM_005100702.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939289.1">
        <property type="nucleotide sequence ID" value="XM_013083835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851271"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939289.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="36931" checksum="D8633A34A2C7D6EC" modified="2025-10-08" version="1">MLMDRQLGVYAHLQPLRLTPVRSTSTCHDNIVTETSKTSVKTVTTVTTSRHADGKHVDRSRTTTTTRTRGKGLVVVNKPVCTSADTTDCEQRYLPEHHATLQDGIELERRVDEKENMETRNGLDVSGEGDSTLTAFGRRLNIKWTDKSDETSENEGLEALSSTVCNESSPVESGGFCVSGTIYHVPRVDHTSCEQAQTSASTHHHQQRVSSSSIIDDAQSLETEPLSSLQADPPDSVGGFRVTEIEYFVPRHTRVRNYSTSKKETNVESSNTLSQSLANTNHVSHSMSQGDDSRDTLPYSSLDLGPIWDISQLAAAGKKTRKKITCYRDYIDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4F4</accession>
    <name>A0ABM1A4F4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease hepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101846827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940643.1">
        <property type="nucleotide sequence ID" value="XM_013085189.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846827"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045978399" evidence="3">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="49"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012940643.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="31784" checksum="1E4AABFF126264AF" modified="2025-10-08" version="1">MDFSRMWSVSIVTLLFVCATCNATPVSIPCSYSANICGVSTVDPMIHRVVGGSVAPMGSWPWTVMLLELGSQVCGGAILSENLVLTAAHCFEGKSIDSHRWNVLAGRHYIDKVDRNEIKVKVQSVIVHEKYNNDTVENDIALLVLHPALTFSPTIRPLCLPPSTQTVSPGQRCMLAGWGDTEGTGSDTALNQAVLPVISDDTCSRADWYGSEFIRSTTFCAGYAEGKKDACAGDSGSPLACKVGGKWYAHGISSWGYDCAEPKWPGIYTDVSKYIPWLQRQMAAHVTCGSSPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A523</accession>
    <name>A0ABM1A523_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 13 member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106012467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940973.1">
        <property type="nucleotide sequence ID" value="XM_013085519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012467"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012940973.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="23834" checksum="6F4A3CE7DE8561B9" modified="2025-10-08" version="1">MARFAEKAVIGHFAVLVTLWLSMKMPGGVGWNSLFTPGFVNNSTSGVIILTSLFIFPSQRPRIFGGNSGTVEGNSKSDSCPTLLEWENVQQMFPWGTFCLIGGGYALAATCQALNLGMNPLYLMVPGVLASSMAFMLPVATPPNTIVFATGHIKASDMGKAGFILNVLCVLVINVGANTWIWSYLNLDQLPPEMNRSSTALPTLWAETTPHSTDVFPTNVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A528</accession>
    <name>A0ABM1A528_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC106012469</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106012469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940980.1">
        <property type="nucleotide sequence ID" value="XM_013085526.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012469"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012940980.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14486" checksum="8C86DEE4146B1381" modified="2025-10-08" version="1">MTILGISRRTWRGLSVLFGGVLVHLSFGTLYTFGNLNPYLTSYMRWHGSDPDLQYIDCAWVFATATMGQASTMFMGGILERRLGPRITCLLGGWFMSLGVVLTYFSVQHSFALTVLTYGVMFGVGIGFGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5A2</accession>
    <name>A0ABM1A5A2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoplasmic dynein 1 intermediate chain 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941095.1">
        <property type="nucleotide sequence ID" value="XM_013085641.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850266"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012941095.1"/>
        </source>
    </evidence>
    <sequence length="686" mass="76462" checksum="F736380313B6C775" modified="2025-10-08" version="1">MADRRAEIAKKKAQIEKLRKERKEKEMAKSQASKDSTTSGSVDTSASDPDAIFRDLGIPVTDTPPQAAPAGQAVSATQGAGEAVVQTVTHASPRRQKVQLSVVKVNETSIPPRENVSYSKETQTINPEPIDKDGRRRRSHSHGSRGPWDYYDDLSDYLSTSGASSPRHGVSVIGHGSPKFIHPHLEWDDEFFDDMDEVLVYDNADHTDDDTDSLDVSADTAHPHRMPHVEMVPPAVSEEETKQEPAKIPELSEEEKKQIMMSEDFQLSMSRATRVMQRMLATKDSSMTTDYSGADTDGKDDDLLAGEKLKLQQEFYDERWSRRRIITSMDWSPQFPELMVASYNANEDAPNDPDGVALIWNLKYKNMAPEYIFHCQSSVMSTCFAKFHPNLVIGGTYSGRIVLWDNRVFKRTPVQRTPLSASSHTHPVYCVNVVGTQNAHNLISVSTDGKVCSWSLDMLSQPQDSMELQSRQNKPVAATCFSFLSGDANNFIVGSEECATYSACRHGSKAGINEVYEGHQGPLTGIDSHCVPGQVDFSPYFLTSSFDWTIKLWSIKQPYHLHSFEDNNDYVYDVRWSPIHPALFASVDGEGRLDLWNLNNETEVPTASASIDGKPALNQCRWHQSGHHIGVGDNTGRIHLFDVGEHIANPKSDEWSGFVHTLQELKQHAAEREEDSSLAGATPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5L2</accession>
    <name>A0ABM1A5L2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101852640</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101852640</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941270.1">
        <property type="nucleotide sequence ID" value="XM_013085816.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941271.1">
        <property type="nucleotide sequence ID" value="XM_013085817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852640"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021899" evidence="1">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941271.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34559" checksum="40922D5CC9E7E124" modified="2025-10-08" version="1">MAGSGWRIFLCFLSLTSDMTPTHQASSTPGIQLSELTYHPTCGLLHNIGTWSMVARANLTVLNSINWKYPSLSFQRLHTDRRDYQTLCMIMFKRDVLADDGSFGCYISKKNETGGFLEATMNMMARLTMSNMTLSVAFRATLTTVDLTHYSNFRTVPIIYDLSKATLEFGGVTYRLEQGIPNSKLLVGQTYNLTFCTRNLLKPFVLSIWDVVGGSYESQDQDCVHSYNMLISRQHLKEAILFKFAETVGCMRTRIYAVYVGQSSSKAAPGPRRPMQSGRVAPWFLLCAIACLLQRREPLRLPGPAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5P3</accession>
    <name>A0ABM1A5P3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101859033</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941318.1">
        <property type="nucleotide sequence ID" value="XM_013085864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859033"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="60"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012941318.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40101" checksum="980E40F1DF9815AE" modified="2025-10-08" version="1">MSFSNLWVNNLTDSRDDSVPITTSPSPSHYDIMSDEQWYIVQVVNGVVLCGLVSLFGVVSNIINIVVFAKQGFQDSMNISLMGLAVSDLCSLVTTIWLSICVNPLFYLSELPFDPRDIMYLTGSMPRYLFVKIATFITAFITFERCLCIAAPLKVKMVITPVRTKMIIISIYITMSILLIPFCLGHRLEWVFDFTLNATVLKTTFTAEREMLEAITYLTQGVFTTTLSFVFVICCTIVLVVKLNSKTKWRQATAAKGDRAAEGVGVKDQKVVKMVTFIAVIFIVSAVPPTLLFFYMLFDTNFRIDGAYPNLYSTIWCLSFLTETVNSSVNIFVYLKMSSKYRAVFIKTFLNKQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9C0</accession>
    <name>A0ABM1A9C0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943306.1">
        <property type="nucleotide sequence ID" value="XM_013087852.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848777"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF64">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012943306.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42898" checksum="901437F675687C1C" modified="2025-10-08" version="1">MRPEQHAKMAAEMKQRLKVEELEENIDELEDVVEDVFPILILTVFVAVLLLIIFLIRLYLRWFAPNPSKNRMDGKTVLITGGTSGIGKCTAIELAKRNARVLIAGREKAKVEAVARNIRKKTGNQHVNALVLDLGNLRSIQEFAEDFRKDEKYLHVLINNAAYMGPLSKTDDGLERSFGVNYLGHFYLTYLLSDKLKKNAPSRIINVVSDSYKQGELDLDDLAMNKGYSVYSAYTRSKLAQVMFNLECHKRYIGNCVWSFAAHPGPTATDLLRNYPGMWGNALRLVSRIMFKPPEDGCQTLVYLAVADGLREFSGKLFTDCKAVKTNEKVKANKELSSRLWNVSAHLCGFEGDALMPEDEPEATPNAEEAGEATAEEEKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9E7</accession>
    <name>A0ABM1A9E7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101849494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943348.2">
        <property type="nucleotide sequence ID" value="XM_013087894.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849494"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="28"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943348.2"/>
        </source>
    </evidence>
    <sequence length="324" mass="36120" checksum="5761A9DAA172EC87" modified="2025-10-08" version="1">MTKTTSQDNEKGTIGGEKVPILLSKRWILAYIGMVGFFFIYSLRVNLSVAIVCMVKDDVNKTTSTNLSTSNEATCTADTPSNSTNNGEFDWDKDTQSLMLSAFFYGYIVLQVPGGWMAGRFGGKRVLGIGVLVTAIATVLLPVAARQDHRAVYALRVIMGLAEGVSFPCMHSMWGRWSPTMERTRLASFTYAGLNVGNVVTYIVSGLLCAYGFDNGWAAIFYLTGGAAFIWVFAWFVFVYDSPEDHPSISQAERDYIVSHRGDKQTKKFKVPWKSVVKSRAMWMCLGAHLCNNWMHYTLLTGLPTFMKQVLKYDIKQASSEFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9F9</accession>
    <name>A0ABM1A9F9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coiled-coil domain-containing protein 96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101856051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943370.2">
        <property type="nucleotide sequence ID" value="XM_013087916.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856051"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051885">
        <property type="entry name" value="CC_CF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025254">
        <property type="entry name" value="CCDC113/CCDC96_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13870">
        <property type="entry name" value="CCDC113_CCDC96_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC113/CCDC96 coiled-coil" evidence="6">
        <location>
            <begin position="479"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="393"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="476"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="624"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943370.2"/>
        </source>
    </evidence>
    <sequence length="667" mass="73903" checksum="C14BFEC22B27E920" modified="2025-10-08" version="1">MFLMTTIMADAQEDTPAAEETKPEEAVEAPAAEETAGEAPGEETVTQDAEATEAPAEVEGGTEQAAEGEAAPAEGGESGGGGEADAEAKPEEGGEGQEAPEPQAEGEGGEAPSEEQQQQQQAEAEGSAEQTEGDAAAADAVAAPAEGGDAVAEADSAEKAEAAEAAEAVDGVEQAEGAEPAEGAEATAAPTEEDGEKPEGAEEEGEKAEGEEGEKAEGEEGEKAGGEEGEKTEEAETGDAEKKEDGEGEDQGEGDADVTAEAPAEDAERAESPVAVGEKLSRGGTPDITDAAHLEQERLEATTPDRLHEEEGEMDHEHDIRDDDMVVEEDEEEEEEEEIVEPQFKREDLIERYHEALSDREQLQQQNYGLQHKLAEYFRKKKADERQDYDKNVTDQEQRYLKYMAQLEDLRRQDSMEKDNYFAQIEEAKARCQEKKEKVDIERGKFMEFKTQVALRAINSRSGKPIPPKDIEQYMINEDKKEKDVVEVRLENIKLKNKLKKKEQQLKSKEELAEGLHLIDFEQLKIENQTYNEKIEERNEELLKLRKKITSTVQVLTHLKEKLQFVQGENLEQSGQLKEVEASLAQSRDILSRTKQARDYLRIDNQKLRQNCGLLGNEPLLRDFEERKDEGDDLKTKLEQLKMKHAELTLHCNQVRRKIDQARQTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA80</accession>
    <name>A0ABM1AA80_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC106013228</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106013228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943821.1">
        <property type="nucleotide sequence ID" value="XM_013088367.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013228"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF108">
        <property type="entry name" value="CLAUDIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046018611" evidence="6">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943821.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17325" checksum="FAC83F2944FB0A58" modified="2025-10-08" version="1">MKPLSIAGFLILGLGLLLHLVGLATPEWVVVRSVPERTEGLFQGCLGKDNCLELTYIPSNIKAVRAMVILGLILGAVGSACALLHLICSFMSRETKAVVPLVVMGTCLAAFIFIIIGVIVYAADYYDVVRKSFNLGYSFALCVVGGILLASGGGLFFLGDRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAN2</accession>
    <name>A0ABM1AAN2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013299</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944070.1">
        <property type="nucleotide sequence ID" value="XM_013088616.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013299"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944070.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="29332" checksum="5F1C888C6CBB00E4" modified="2025-10-08" version="1">MQARAEKNRECWEKLNAARPGRLWSREKGVVRNGGEAKEVAGMKVTEQDMTKQEVAGVKRKVAEERQICCGTRATAPSNGRDGAELAADTTTLNNNNNNNNIKNNVCNDGGNGIDSEGGVSSKKQRLDGWKKFPLKAEAGVGLTSAPPARRLSSTAQRDSVSPRSDSSGTGKVREVDEEEVGGGVRSSHTDVLGDCENLHDARVSVSVSHMFPCISRGLAWATHGREPLLSLTQDDLDLLPLPAGLSGADHVQVLVTGSLLLVGGVLTVIDPGMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAQ4</accession>
    <name>A0ABM1AAQ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Filamin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10" type="primary">LOC106013305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944101.1">
        <property type="nucleotide sequence ID" value="XM_013088647.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944102.1">
        <property type="nucleotide sequence ID" value="XM_013088648.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944103.1">
        <property type="nucleotide sequence ID" value="XM_013088649.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944104.1">
        <property type="nucleotide sequence ID" value="XM_013088650.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944105.1">
        <property type="nucleotide sequence ID" value="XM_013088651.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013305"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012944101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012944102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012944103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012944104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012944105.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13398" checksum="AFE359A0E9A60AF6" modified="2025-10-08" version="1">MQYEEDPDWDEEEEMTTTERELADDAQWKLIQKNTFTRWANEHLKTVNKQLADLESDFSDGLRLLSLIEVLSGKKFKHVNKRPNFRTQKLENVTMVLKFLEEDEGIRIVNIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABE1</accession>
    <name>A0ABM1ABE1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-parvin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101858525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the parvin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944463.1">
        <property type="nucleotide sequence ID" value="XM_013089009.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858525"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21304">
        <property type="entry name" value="CH_PARVA_B_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21306">
        <property type="entry name" value="CH_PARVA_B_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028433">
        <property type="entry name" value="Parvin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114:SF4">
        <property type="entry name" value="GH23568P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114">
        <property type="entry name" value="PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039131">
        <property type="entry name" value="Parvin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="84"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="253"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012944463.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42536" checksum="BB127676E29B8C1B" modified="2025-10-08" version="1">MATSPNTSTLSPKKKDESILEKIGTMGRKKKIKEVAELQEEGKHAIESPTSPTIADIGPEGYQLADNEERSMIEPSSRENPKLMELVKVLLDWINDLLADHRIIVKDIEEDLFDGQILQKLIEKLCNVRVEAREVTQSEIGQKQKLRVVLDYINHTLNVPPVWSQQKWSVDSVHSKNLVAILHLLVALARHFHARIRMPDNVTVTLLVIQKVDNILQTRYVQEEITTNYDDADGRSERDAFDTLFDHAPDKLNVVKKTLLTFVNKYLMRLNLEVTDLDNQFHDGVYLIILMGLLEGYFTPLYQFHVTPTTFEHKVHNVKFAFELMEDAGLQKPKARPDDIVNLELKSTLRVLYNIFTKYKSSHGSQTGPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACJ9</accession>
    <name>A0ABM1ACJ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM102A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EEIG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945110.1">
        <property type="nucleotide sequence ID" value="XM_013089656.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862079"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945110.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="23909" checksum="757AA49E2DB83F01" modified="2025-10-08" version="1">MMPFMSKKKKFKFQVHLGLEELASVPFVSGVLYAKVRLNDGGSFLEQSPRQEVHNNCVRWGAEFEFPCKMTASLTSGVLDPCFVRISVRKEVKGGKSQQKLGFVDLNLALFAGGGQVSRRYLLEGYDTKHRLDNSNVKVSVELALVSGDPVFKVPSSHSVSQSSSVTGQSSDPIDLRPCDNHSEDSLASSSSGFSSLTRRGKLSEVMDQDPSSTATAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACW8</accession>
    <name>A0ABM1ACW8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Integrin alpha-PS1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101857916</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945283.1">
        <property type="nucleotide sequence ID" value="XM_013089829.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857916"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00357">
        <property type="entry name" value="Integrin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13 18" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1052"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="167"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="292"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="363"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="428"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="14">
        <location>
            <begin position="475"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="647"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="16">
        <location>
            <begin position="804"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012945283.1"/>
        </source>
    </evidence>
    <sequence length="1108" mass="123335" checksum="FC1FC6F4DFFCE29A" modified="2025-10-08" version="1">MAACRVVPRMEFLLLYIFSFVIVVEGINYDPRFSLIKKGQDGSYFGFSVAQHQIMRDKNSVEENVLFVGAPKENVVIGGKNTGGALYRCNARQLTDCSRITDGVSTPPRSNELLEDQWLGVSVASQGPGGQLVACAHRAIKDNAALGYCNVWDQEFFHTVLFRPCQNLPHTLFMKNFGLCQAGMSSALGQDDALVMGAPGSVYWQGVMFYVNVTDELGVSWKEVPSPYRRSDSQGTGQLSPTSSYSYNGYAVTMGKFDGTKQLYYVSGAPKSSSLGEVVIFTHRSDNALRYDKSQILQGRRLFSGFGSSLAAVDINNDGYDDLIVGAPYYYKKNHGGAFYVYLGGPSMFEGTVHTEVLSRKLGTEECEALLCEHARFGMSVSKIGDVNMDSFQDFAVGAPYEGTGAVYIYHGDNSEAGFNTDYVQRITASDLPQDVQPLSSFGYSLSGGIDLDENGYPDLLVGAYESDAVVLVRSRPIIKLHADLNVMPESIDMEAPAECPFIAGENRRCLKIELCVNYTTRPLNSIKVFPTLVYSVEAEKQRKIARVELKDSTDPFKKVLENRRVQLSPSTTCVEEYAFVKNSLDDKFNRIEFTFSFSLDLSDDDISSYPDSAIQDVNRFPVLDTEGSAGDSANSVVAWADFVKDCGDDNICNSNLQFDALLDGLSQDENGNYELIIKRENTLQVIMSVANLGEAAYETRIYVKKPKGVSYIGTESQDSVSCQGLKEDETLIKCERIGNPLRTDKSVYFILKLNVPRELVESTEIYNLTAWVNTSSLEESVVNDKHVLNFKVINKAEIFMDTNVNPDYAIMSQGQPRGASSMKDELSIGHAVRHNFIVRNSGPGVISKSFITIYWPYEVGDAAAGSGKYLLYMMRKPKIVGPVVKCNDEDIQKYINPLNIKEVRDTQLAEPVVEASSDDDIAVEEVEVKPLPDSDEAGTRRKRSAGRRVRRAAGNVVVMSCRDGTARCFEYKCMLGRLEANVNYVKITMESRLWESTLLADYQKASEVQVISWANVTISKKLMITQNTDDDEKRAVTRVVFKETSSQTVQWWIILVAVLVGIIVLLVVIFILYKLGFFKRKRQEDMQMYKAEKKQQAMLSEYDDDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEE0</accession>
    <name>A0ABM1AEE0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">COP9 signalosome complex subunit 7b isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC101847167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946085.1">
        <property type="nucleotide sequence ID" value="XM_013090631.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829430.1">
        <property type="nucleotide sequence ID" value="XM_035973537.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847167"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041481">
        <property type="entry name" value="CSN7_helixI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18392">
        <property type="entry name" value="CSN7a_helixI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012946085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035829430.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32197" checksum="22DF28258F729E2E" modified="2025-10-08" version="1">MSAEKSGNPMEPFLLLLKDAKGAGAASVLTQAMASPNVYVFGEFLDLPNVQELSSGPHASVYQLLQVFAYGTYKDYKANQAQLPDLTQTQLTKLRHLTVVSLATRSKCIPYSVLLEELAMENVRNLEDLIIEVIYADIIHGKLDQKNQQLEIDYAIGRDIHENALSEVTVVLQQWCNGCEGVLKSIEEQINRANNCKVQQNQLKAALEQEVNNIKKTIKTSQQQDIEEVMVTDSRSDMAMAEKAGKKSAKTKGDVIILQAPRQQRREALEQMINPHDMAWMAYSGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFC9</accession>
    <name>A0ABM1AFC9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101851706</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946585.2">
        <property type="nucleotide sequence ID" value="XM_013091131.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851706"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046452026" evidence="1">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946585.2"/>
        </source>
    </evidence>
    <sequence length="153" mass="16841" checksum="BD54054C0F544021" modified="2025-10-08" version="1">MQFLALFLLVAPVAYTVAAPDPSTICLPEKSTASVFGLIQKFQANVSIDFSQNKVAAVTELGTRVSDLNTNYTYLIDATGACTREPLPIFGYITRCLPPSSVFLGEVFEGFVNKVTLNGWLIPVNKDFNVTLLTYTEPGQTDSYFVLRRDDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFP1</accession>
    <name>A0ABM1AFP1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial sodium/calcium exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101859543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946734.1">
        <property type="nucleotide sequence ID" value="XM_013091280.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859543"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="62"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="398"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012946734.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="60883" checksum="3F5D887E3145358F" modified="2025-10-08" version="1">MGDSDNGPDCSDLHSIPNLTDFCAFVRNTSSCDIDEGFINYTAFLYCTLDNLVIEVACLILFIWWFFLFTGLAVTADDFFCPSLAVISQSLKLSHNVAGVTFLAFGNGAPDIFSAIAAIGNAKAGDAGLAIGALFGAGVFVTAVVAGSIAIICPFTSMERPFLRDVIFYLAATFWAWYVMWDKKITQVEAAGFIGLYVVYVIVVILGRAINQRLKKIRTGSQMGRLLEESLTSSEVERDESQPLMSSINRRVSPSVQIEQDPGESNVESIGDRGLWRAFLDDVNPIDVEGWREKRIFGKVFECFKCPLMLVLNFTVPVVGEHNESEPNDPRNWNRLLNSLQVFTGPVFACFATKLGLNWIGGVFPVYALVMVVCAILAALVFFTSKTDERPPYHTAFAYLGFVVAVVWIYSIANEIVNILQAFGIVFDLSDAILGLTLLAWGNSIGDLVADMSLARQGYPRMGISACFGGPLFNLLIGLGVPFTIACLQKDGVFHLAVTLEEMVLAAGLGTSLIATLLIVPLSGFKMSRPYGIALVCLYVAFLVIAILTETNVIPNSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFQ4</accession>
    <name>A0ABM1AFQ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transcriptional repressor NF-X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101851704</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946753.1">
        <property type="nucleotide sequence ID" value="XM_013091299.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851704"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd16696">
        <property type="entry name" value="RING-CH-C4HC3_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="405"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="408"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="14">
        <location>
            <begin position="1035"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1154"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1173"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012946753.1"/>
        </source>
    </evidence>
    <sequence length="1210" mass="134266" checksum="6E32AAB3A7E499C4" modified="2025-10-08" version="1">MSWQEQYSTPTFQPVTVPGMRASDLEAQMYYNSSQGYYPSVPGPMYHNGQSAVFTNTGYYPQAVPVDGFHQGYSEVYVPQGFRSTNSYGTQSSNYNVPDMQMQTDMASGSGGANTDGSSYAASSTYPHHQEAGYQSDRGRDKKQGKGRGRGNGWGRGNRGRDHGNGRHYYPEHHDSSQTNYYNGDQYYHHDNHHYNSNVGRKSRGRGGPKYADYSSRQNYNQIGNGDGNSQDFYSDKGHVFERGGKYGNKKRAEQQARRNDDVSTPDGVSAVSDYVPEQVDLKRVSGTKGFDSEKNRKSTTVAFANSEGPGRKQRHYGEGTGVNVINGEKTNSAERQDRDPQTYELKQQYQKRKNKSIPSSARGGRDFGRGGTRSKTSFNGRTDDSRPNDESQRGSLTDQLSQNKYECMVCCDIVRVDDAIWSCQQCYHVFHLSCVKKWAHSSMQRETKSWRCPGCQNVTDHVPYQYRCFCGRRRDPAYIRGETPHSCGETCKKRRKGNCKHPCTILCHPGPCPPCSAMVWQSCDCGQDRKHIRCSTAQAYQCDKVCKKPLNCSEHTCDQICHTGPCAPCSVSKQQECFCTKTSRTVLCGTENFKMVSFSCEKPCGRTLSCGNHTCEELCHPGECAPCPLMPGQLTTCNCGKMPIAQLKAAERKSCLDPVPTCEKPCELPLGCPVKDGPPHLCDKICHEGECGPCKKKTRLRCVCGGVEKEMDCSVAMTYTAVDPFKCQRRCGKKKSCGKHKCLDTCCVKDFHICDLVCGKNLACMNHRCEELCHPGYCKRCLQASFDELTCYCGAEVLEPPVPCGTKLPECHRPCTRDHACSHPVRHNCHADERCPPCTELTERMCMGGHMMRKNVPCHMTNISCGYPCQKMLFCGKHKCLRTCHKDSCLKAGAPCPQLCTKPRPACGHPCNEPCHEGECPDTQCKAEMTILCPCGNRSGRVICSLGGGQTSEIEQFQRLSVLSVAESGGGRSVDMAQFSQQKKNQRRLECDANCSVLERNRRLAEALEVDDPDLEVEKPKYSDFLKDFAKKNLQYCMSVEKTLNELVLASKESSQATKSHSFPPMKKEHRHFIHELSEMYGCRTQSFDKEPNKNVVTTALKERSVLPSVLLSQSLSQNPSSAAAAAAAAAATPPPISSLKTQGVRFKVLDTKKTSLEESSGSGKGGLNPWGRKEPAKEEAAAPNRGWEQTGAKAKPAPSIDYFDFTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ00</accession>
    <name>A0ABM1VQ00_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Orphan steroid hormone receptor 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101854540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824492.1">
        <property type="nucleotide sequence ID" value="XM_035968599.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854540"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="131"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="404"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035824492.1"/>
        </source>
    </evidence>
    <sequence length="790" mass="84382" checksum="279602D09B10F990" modified="2025-10-08" version="1">MPHPGVCSALASQNLMATLEEGTAVETKKELGSEIDAAAAAVIDGAEMIHVMTSGSSGSVTLPITLTQGGLVSLTSPGQSVVQVPAGSLAQVDWASKLKELQHAQRLERLREEQRQVQDRVTQKMQFEQKYEPCVVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYACRGSRDCPVTKLHRNRCQYCRLQKCLAVGMRSESVQQERRPSDQRDKVPVTVATSTQRIYIRKDFNSPSAAIPTFSPKVQSLEDPKYGSLLANLQERVVQTDQGMVVLSSQMPSPSSTVNTDLTTLANVVSTVSNTEDLSTLADVVCTVNNTEDLSTLASVVTTLATMGKEEVNLEELSAGQTASPLQNNGDANRNTPDAAARAFDNLAKAVQSPQSQQNSTVLDQSGLSEASFDQSANSDGENSLLVETQGPILTEANFAFTLTTPSPMPTYLNIHYICESASRLLFLSMHWTRSVSAFQDLGPDLQTTLVRSCWSELFTLGLAQCSATMCLPTMLAAILNHLQASLQRGDHSNQEKVKSVIEHIIRLQDYVTHIQSLNITSAEFAYLKTLVLFAPDNPNIRDKRVISRLQERSRRELLQACSSPGSSERVSQLLLRLIPLKTFVPAVMEELFFSALTGSVQIDNIIPYILRMETAEYNLQMTGQTGAAAVAGISGGVGVPALHDPSAPNQPPSVPVILESSQQVALAASATEAATISVGDGIANGSSNGNIVTATSNGGEVRLVSSGTGSTSGQGVALGNNNMAGASIHRASLLSDAGQVLTLYTDGTAATQNSQAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQF2</accession>
    <name>A0ABM1VQF2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106011246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035824644.1">
        <property type="nucleotide sequence ID" value="XM_035968751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011246"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="854"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="933"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824644.1"/>
        </source>
    </evidence>
    <sequence length="967" mass="108836" checksum="D91097AB92C62DC1" modified="2025-10-08" version="1">MGKCAKSVVACVVLTLMVTLMTIQKTSLIMSLRVVLHHSVEIEAGYAVLSVILLAPYLFSVLLTMWNVPFLRKAEGSPWPPLQSIFLSLFSSVVEAACLVTFTTRVMVLLPVYVALPAAHSTLAVSSVIVSVQRKWKPSPTTGHGKPDSPPEKVDDSSFCWHGARIMASVMCLLVPPAVACFLYVMDLADGVSSLCFGISYLALALCQPLFGVVLPSLFSMVASIVLCVSLAPVMYGIDETKDLGSFSPLLICASVLAWAWAWPYILNSHNFLRRPSFLLTPYKAMFLDFGWNPIFHDSRLLLGYNCKQSVEVLTYGPQKKNRIYICTTMYREADYEMERLLLSLVELSTDPVLQDVHFESNIFMDNGCTGETLNEFALQFIALLVSKAGVELNQARCYRTPYGIQIFCKLSTGLPLFVHLKDAQKVKPKKRWSQCMYINYVMRHRKTLWHNDHNNKRFFKDLEDKLKSQGKDDLGDMQLDQTGQFMLRRVANIGYPTLAEFKVVTDSDQGFVSVDESSPSNSDSGSQGRVYSSSKESSDLDSLSEEKPRSNGRAGYENKGFQDDEDIIHSSSMDMKDKMVARRLARLTDIAGRIWLVRRNFGDRKLYTLKIPVFDVARLIMRNNSALTVLYKVLLLNFLLGASDVINFPKADTTPSSDDDIFNSSTLVDDDHTFILATDADMDFKGEAVRELLDLCNADKRVGAACGRTHPIGKKCSSIVWHQVFEYAKDFWMIKNAQNIIGSVSCCPGCFSLYRGSAIRDVMTKYASPTRAPYSVYVKDTGEDRWMATLMMINGWRMRYSPFADNTTYCPDSFGEYYKQRKRWILSDMANAVLVVQNLFRLIRNNDCFSMMYVVYLVNMFLNNIITPGTAIVMITAATTTTTTTRLHPCPSPEAQSGNFHFQQHYVILLLALSLVYAALMHPRESYQIVYGVAYLFIFPAMHVLLPIYSIANIVDQSWGTRDSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQQ4</accession>
    <name>A0ABM1VQQ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">THAP domain-containing protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC118477428</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824746.1">
        <property type="nucleotide sequence ID" value="XM_035968853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477428"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035824746.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36094" checksum="F2B5B039BA57F8AB" modified="2025-10-08" version="1">MTSLPSTSRQDKLGGNQCCADGCQNARHGLPFFRFPRDEARCKIWIQNMGRLDLLEKPLSELGRKGYSLCCEHFESDQFDVPFERRHLKWNAVPTLFKVSLPIPPTQKRKSGSSPQKKFAKKLGLEKREDQADNGAHRLIGETMKSSSEEKNRLEGILVSSHDNDFQQSTLPNQHDPVVLLKRIAVPEEVNPTAGKKLVIPLAIKKEEDISCPPEMERETVVTAWRKSVQAQQALPSSSAEADVSVHASQVPAAGMEINVMGNHLLQESPAPQKQDSVAKYVRALEDISSGAEVTQEVAVQTPSGRKFKIYVVAVEEPDSSSPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQT7</accession>
    <name>A0ABM1VQT7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Tenascin-R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101864679</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936118.1">
        <property type="nucleotide sequence ID" value="XM_013080664.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824778.1">
        <property type="nucleotide sequence ID" value="XM_035968885.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824779.1">
        <property type="nucleotide sequence ID" value="XM_035968886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864679"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="164"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035824779.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="45711" checksum="0A887F504AF89B5E" modified="2025-10-08" version="1">MFKRKTSLKMSRCTARSKRQTTMAILETTICRQKTRILILFILLLSHRRTSAVYFTRGTPCRGYTPRSLSCEAKAFPTEQQGLLSCARLCARADVCVGVAMDEKGQCYHYQECLSADTCSVDDDPQWLRLPFYGKNLGFAPSALPQEVCLNAGVWNQSTESCQCTGGWIGVNCQMLASKCSQLVGLYPDGYHVVSMKLHRIITVRCQLMSKEPGANTYIALSHGNMSFNRTWEDYVLGFGLPSDQNFWLGLENIHAVTASGLSILSIDIVLDFQMYASSMVRYKNVFVGGPSTKYALGVTWDYDFTTPTFSSAVGESNRLGDCLSKVSQTPFSTFDADHDLNPGDSCASRAGSGWWFTDCDPDCNPLGWSYTARPGPQNPGHLLLKGLDFSDGSSYKNLFAHLDVYFYQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQW8</accession>
    <name>A0ABM1VQW8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Three prime repair exonuclease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106011363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824810.1">
        <property type="nucleotide sequence ID" value="XM_035968917.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011363"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="9"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035824810.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32905" checksum="39A94A2D579C7FCF" modified="2025-10-08" version="1">MANREAIQSFVLFNSESTGLPQTRPRIIELSFIAVTRDALLNLGARSTPRVLNKLTLCFNPKKDIEEEAAGVNGFTDLHRADLELMKTFENAASLVISFLESLPRPVCIVAHYGNSFHFRLLLAELKRARQDIPEHILRVDSHMALRALEKLKPLSEYTGRNTSDESVSRRRREGLSLSDVKDEPLDGRMREGLSLSDVKDEPLDGRMREGLSLSDVKDKPLDGSGAENKSSGKLSYKLTAVHSRMFGPEGEECHTAENRCKTLLKIVLALSESFIEWCDDKAQPLNTVGLMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQY5</accession>
    <name>A0ABM1VQY5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase XIAP isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824827.1">
        <property type="nucleotide sequence ID" value="XM_035968934.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848737"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824827.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="60423" checksum="D40223E9669EE1FC" modified="2025-10-08" version="1">MASASFMERLRTFHSPLPQNFVSLLSNTPIKFAEAGWERADNIPNASDELVCRSCSVRHSGWSGEPPLAVHRTRSPNCPFLNTPPTVPLHFVATSSSSEVNVEDVQEPETIFSICSSCDANNEETLKRKLFPNRLNNNHSFAKYGRRQAIVHPFKPLAGDYPMLFESLRRTTYDIPSSTEAAKWSKEGFIMISSLCAKCVFCGLQIEFNVCIDIGDVHKEKSPECPFVCHFDVGNITSEEQRSILEKERSKHFADMNEGNSSVVKQYSIMYPEFESPTDRSGTFDLWPKILKTMFSLDVMVDAGFYCTGHNDMVRCFSCGVELFDWMPGADPLTQHARASPSCFFLQHNKGQEFINNAQQQELVVGVKQDSRAQDLEAAASPTTEIISATPPSATSSTPKPSPPPAGPRPYLDLESISAARARGYSTEQISDAIITFFYLTCGQFPDSPLLLGLLKAGTDNHKTLCDKTQENLDIKSEVKAKETEIQAKDTEIQAKDTEIQAKDTEIQAKERELQRQRFERHWRELAVKTELEQVSHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VS46</accession>
    <name>A0ABM1VS46_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catenin alpha-2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825238.1">
        <property type="nucleotide sequence ID" value="XM_035969345.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860647"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF9">
        <property type="entry name" value="CATENIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="329"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825238.1"/>
        </source>
    </evidence>
    <sequence length="902" mass="100446" checksum="162B55F3D92F4721" modified="2025-10-08" version="1">MSMSPVPQQGTLQVKWDPKNLEIRTKSVEKTLEPLVTQVTTLVNQNGPSNKKKGRSKKAHVLSAAVQKATENFIIQGEQIAHDFPEVENDMLAAIDEVRKTGETMDDASQDFAADPCSSVKRGAMVRAARALLSAVTRLLILADMVDVHLLLKSLHTVEDDLDRIKNATSQQELTDGFRDFGRSMAELTDRAARRQADLKDPRRREELAAARATLKKNSMMLLTTSKAYVRHPELAAARSNRDYAYKQVCDAVNAISDVAQASGQSNAHPYEGPGELAAALDELDQKIIMDPLNYNEVRSRPSLEERVESIISGAALMADSSCTRDDRRERIVQECNAVRQALQDLLTEYMNNAGKKEPSEELEQAIDNMTKKTKDLRRQLRKAVVDHVSDTFLETNVPLLVLIEAAKAGDEKGVEEYAQVFMEHANKLVEVANLACSMSNNEEGVKLVRMAAAEIDNLCTQVINAARVLAARPKSKAAQENMDVFKDAWEKQVRLLTEAVDDITTIHDFLAVSENHILEDVNKCVIALQENDPDTLDRTAGAIRGRSSRVCNVVSAEMDNYEPGQYTERVMEAVIMLRDQIMPNFAEKVEMAVDALSSNPTRDVDENEFIEASRLVYDGVRDIRQAVLMSGVDIDESDSEDYEDEYGGYAQSSVMDHDDYSGKSDRAMMRRLPEEEREVIQQQVEMFRMEKAKLDREVAKWDDSGNDIIVMAKQMCMIMMEMTDFTRGRGPLKSTMDVINAAKKISEHGTNLDKLATTIADQCPDSQSKKDLEAYLQRIGLYCHQLNITSKVKADVQSVSGELIVSGLDSATSLIHSAKNLMNAVVLTVKACYVASTKYSKGSNRHVVLWKMKAPAKKPLVRREDPNELGAKVRKGAATRSAIEPIKALSEFQEVDPDSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT54</accession>
    <name>A0ABM1VT54_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arylsulfatase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825596.1">
        <property type="nucleotide sequence ID" value="XM_035969703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861504"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
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        <property type="entry name" value="ARSB"/>
    </dbReference>
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        <property type="entry name" value="Sulfatase_N"/>
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    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047316319" evidence="6">
        <location>
            <begin position="20"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="169"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825596.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49521" checksum="A507892821E1D696" modified="2025-10-08" version="1">MLRLFLIFPVLVLLTAVNGKPPHVVFMVVDDLGWNDVGFNNPDIISPNIDSLAHGGVILDHAYVQPLCSPSRSAFMTSYYPFRLGLQHLVINEGAPVCAPLDKTFLPQVLKRHGYSTHMLGKWHLGFCRWECTPRYRGFDSYYGYYNCAEDYYTKIRRESVVNISCVPLQVPKQYSDMYPNVTIEGRQIFSGMVTAADDVVGRMVKVLKEKAMFDDTIFFFTADNGGWVSFHGNNYPLRGSKFTIWEGGTRVPAFVHGKPLQKTGVRYEGLMHAVDWFPTILEAAGNCPDPDSDGISQWESITTLSPSKRTEFVYNLDNHTDPVQGHAAIRVGDFKLIEGIPGLYNGWYKPDNSWTGLEPSFFGHSNWTDFKGLYNIKDDPHEHTNLYDKLPEVVKKLQARMSHYYTKMVPANYPPQDPKADPKNFDMFWQPGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VU90</accession>
    <name>A0ABM1VU90_APLCA</name>
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        <submittedName>
            <fullName evidence="5">Transcription factor collier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825982.1">
        <property type="nucleotide sequence ID" value="XM_035970089.1"/>
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    <dbReference type="GeneID" id="101860543"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032201">
        <property type="entry name" value="COE_HLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16423">
        <property type="entry name" value="COE1_HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Transcription factor COE helix-loop-helix" evidence="3">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035825982.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="20305" checksum="02F66DDC203CE1E3" modified="2025-10-08" version="1">MMYSAALTEPTIDYGFQRLMKLVPRHPGDPERLPKEIILKRAADLAEALYSMPRNPNQLSLPTPRSPAMNNPAMSGFNAYPSQLAVSVSDTAVNAGYNRSQSSSVSPRGYGSNGSTPHSVNGGAYGAAPSMNGYHSGPGPLGNMGLDHFLRDEASRIGAGMGGIVGSPFSSVNPFGLPTCGTQSAYGSSIVSPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUN9</accession>
    <name>A0ABM1VUN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mesocentin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101859248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826131.1">
        <property type="nucleotide sequence ID" value="XM_035970238.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046924106" evidence="6">
        <location>
            <begin position="24"/>
            <end position="3136"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="7">
        <location>
            <begin position="96"/>
            <end position="254"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="327"/>
        </location>
    </feature>
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        <location>
            <begin position="754"/>
            <end position="2854"/>
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    </feature>
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            <begin position="2872"/>
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        </location>
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        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="306"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="756"/>
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        </location>
    </feature>
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        <location>
            <begin position="808"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="821"/>
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            <begin position="914"/>
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        <location>
            <begin position="924"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1098"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1137"/>
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        </location>
    </feature>
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        <location>
            <begin position="1332"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1410"/>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
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            <end position="2822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2824"/>
            <end position="2838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2840"/>
            <end position="2851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2893"/>
            <end position="2903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2914"/>
            <end position="2926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2927"/>
            <end position="2939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2940"/>
            <end position="2949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2983"/>
            <end position="3014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3025"/>
            <end position="3087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3107"/>
            <end position="3126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035826131.1"/>
        </source>
    </evidence>
    <sequence length="3136" mass="340872" checksum="E717162D3F14829A" modified="2025-10-08" version="1">MARMKHFLFIGIVCCLLFAAVKADDDDEATVEDDLGKSRDGSRTDDEVVQREEEAISLDGLSVAQMKELRDNSEKHAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRFLSLTDKEALSATDELSIKIKADPESKVLHITDTGIGMTKEDLVKNLGTIAKSGTSDFLAKLGEANTATETSDLIGQFGVGFYSAFLVADSVIVTSKNNDDEQYIWESDADSFSVVKDPRGNTLGRGTTITLVLKEEAHDFLEANTLQNLVKKYSQFINFNIFLWTSKETEVEEPVEEGEEAAEDKKEENAEDEDDEAKVEEEEESDKPKTKTVKKTVWDWELMNSVKPIWTRKTADVTDEEYGEFYKTISKGQEEPMAKIHFTAEGEVTFKSILYVPKTAPYDTFSNYGKKVDHIKMYVRRVFITDDFEDMMPKYLSFVRGVVDSDDLPLNVSRETLQQHKLLKVIKKKLVRKTLDMIKKIDKEEYAKFWKEYSTNIKLGVIEDTSNRTRLAKLLRFYSSNSDTEQTSLAEYVERMKEKQEAIYFVAGTSREEVEKSPFVERLLKKNYEVLYLVEPVDEYCVQALPEFEGKKFQNIAKEGLSLDTSEKAKERKEAQEKEFKPLVDWLKENALKDKIEKATISERLTTSPCALVASQYGWSGNMERIMKSQAYAKQGDASNQFYASQKKTLELNPRHPLIKELKARVEADAEEQTAKDLAQVMFETATLRSGYAVPDSAGFAERVERMLRLSLDIPLDEKVEEEPEEEEDDAAGVVDENAEEEVQADEEEGQVSCGTNKQPRRGIQWFGNLLERDTDGDGIPDHLDDDDDGDGIPDDEDNDDDGDGIPDDKEDSDGDGIPDMVDNDDDNDGIPDDEEGDSDGDGIPDYLDEDDDNDGIPDSEDKDDDGDGIPDDLEKDTDGDGVPDHLDEDDDGDGIPDNVDNDDDNDGIPDSNDVDSDGDGTPDYLDNDDDNDGIPDSEDNDDDGDGIPDGQEDSDGDGVPDSLDKDDDGDGIPDDQEKDSDGDGIPDDEDDDDDNDGIPDAEDNDDDGDGIPDGQEVDSDGDGIPDELDDDDDNDGIPDSEDNDDDGDGIPDDKEKDSDGDGIPDDVDDDDDNDGVPDSQDNDDDGDGIPDLLERDTDGDGIPDYLDDDDDNDGIPDEEDDDDDGDGIPDDQEIDSDGDGIPDEVDDDDDNDGIPDDQDNDDDGDGIPDDQEVDTDGDGVPDYLDDDDDNDGIPDSQDKDDDGDGIPDDKETDSDGDGVPDHLDNDDDNDGIPDSEDNDDDGDGIPDDQEKDSDGDGIPDDVDDDDDNDGIPDSQDNDDDGDGIPDSQEKDSDGDGIPDDVDDDDDNDGIPDSEDNDDDGDGIPDDQEKDSDGDGIPDDVDDDDDNDGIPDSEDNDDDGDGVPDSQEKDSDGDGIPDDVDDDDDNDGIPDSQDNDDDGDGIPDDQEKDSDGDGIPDDVDDDDDNDGIPDNLDNDDDGDGIPDNQEKDSDGDGIPDDVDDDDDNDGIPDSEDNDDDGDGIPDDQEKDSDGDGIPDEVDDDDDNDGIPDSEDNDDDGNGIPDSQEVDSDGDGIPDDVDDDDDNDGIPDAQDNDDDGDGIPDDKEDSDGDGIPDSEDNDDDGDGIPDNLEKDTDGDGVPDYLDDDDDNDGIPDSKDNDDDGDGIPDDKEDTDGDGIPDSQDNDDDGDGIPDDLEKDTDGDGIPDHIDDDDDNDGVPDSEDKDDDGDGIPDTKEDADGDGIPDAIDNDDDNDGVPDYLEKDTDGDGIPDYLDDDIDGDGIPNDQDDDDDGDGIPDKLEDSDGDGVPDYLDDDDDGNGIPDHLEGDTDGDGIPDYLDDDIDGDGIPNDQDDDDDGDGIPNDQDDDDDGDGIPDDMEGDTDGDGIPDYLDDDIDGDGIPNDQDDDDDGDGIPDHLEIDTDGDGIPDYLDDDIDGDGIPNDKDDDIDGDGIPNDQDDDDDGDGIPDSLEQRDTDGDGIPDHLDDDIDGDGIPNDKDDDIDGDGIPNDQDDDDDGDGIPDHLEVDTDGDGIPDYLDDDIDGDGIPNDKDDDDDGDGIPDHLDVDTDGDGIPDYLDDDIDGDGIPNDQDDDDDGDGIPDFLDVDTDGDGIPDFLDDDIDGDGIPNDEDDDDDGDGIPDDQEDADGDGIPDYLDDDDDNDGIPDHLEVDTDGDGIPDYLDDDIDGDGIPNDKDDDDDGDGIPDVLEVDTDGDGIPDYLDDDDDGDGIPDHLDVDTDGDGIPDYLDDDIDGDGIPNDEDDDDDGDGIPDNLEVDTDGDGVPDYLDDDDDGNGIPDYLEVDTDGDGVPDYLDDDDDNDGIPDELDDDDDGDGIPDHLEIDTDGDGIPDFLDDDDDNDGIPDHLDEDGDGDGIPDKFQVDTDGDGIPDYLDDDDDNDGIPDSQDDDDNNNGIPDDQEVDSDGDGIPDYIDDDDDNDGIPDYLDDDADGDGIPDFQQLDTDGDGIPDYLDDDDDNDGIPDELDDDDDGDGIPDSQELDSDGDGVPDYLDDDDDNNGIPDHLEKDTDGDGIPDYLDDDDDNDGIPDELDDDVDGDGVPDSLKTLDLNKNGVPDYQEIDTDGDGIPDYLDPDDDNDGIPDELDDDDDGDGIPDDQEIDTDGDGIPDYLDDDDDNDGIPDDEDFDADGDGIPDEEEGDTDGDGIPDYLDDDDDNDGIPDSVDTDKDGNGIPDFMEKDTDGDGIPDYLDDDDDNDGIPDFLDNDDDGDGIPDDKEDFDGDGIPDYLDDDADGDGIIDKLPDSDGDGIPDIRDDDDDNDGIPDNEEDTDGDGIPDYMDEDANGDGIPDKEQDSDGDGIPDYLDDDDDNDGIPDSLDNDDDGDGVPDQKDGGKCDKDSCPKKPIKPPVKKSKAKERATFWIRIKNALKKMMAAALEHDGLKKRQNKTPPPVVKQKPHDQKYDLVDVVKQLIWGKDGDDDDDDDDENDDDDKKDKADKKDGNDDGDDDDDNKNDELSDTPIKVVPSKIKPTFQKGVKFSAPTLQQKKFQAAKKAPPKNANFEAAKKAAALRAAGKTAPVAKKSPMDSKTAATKQLTPQQLQQLKQQYAQKAKTQQQQQQKPPPQQQKQKTGQKAPVKQQQKQQAPVKQQANLKQKQPVKQSPPTPKSTNQKPPQQKLPPQKQPAKQVLKNTKPTKKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VV39</accession>
    <name>A0ABM1VV39_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory-associated protein of mTOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106012048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826281.1">
        <property type="nucleotide sequence ID" value="XM_035970388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012048"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826281.1"/>
        </source>
    </evidence>
    <sequence length="992" mass="110536" checksum="A7BB3B19D0DC4B80" modified="2025-10-08" version="1">MVDKIPGQISDRRTMLGELNWIFTAITDTIAWNSLPRDLFQKLFRQDLLVASLFRHFLLAERIMRSYNCVPISNPQLPPTHQHPMWQAWDLALDLCLQQLTVKPSGDSVSFTHSPFFAEQLTAFKVWLDYGSQVRRPPEQLPIVLQVLLSQVHRVRALDLLGKFLDLGPWAVNLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSCQTDLVKDNGHKYFLNVLSEPSMAAEHHTMAAFVMAIIMNNYPPGREAALKDNTISICLEQLGDKDPHLRQWLALCLAKVWTTFDNARWCGVRDRAHEKLSKLLSDPEPEVRAATVFALGTFVSRSLDRTDHSVAVDGNVGNLLVECITDGSPLVRKELVVAFGGYVAVYISQFITLVKRLLEEENKDRMTTSLDITSMMGPRDAQRPLDSFNSGGMRRSQSRGSFKNLPTSASSHQLSSLASAAADCPSDERVLIRRVSSGVSLAGQTFVTVYSSMWQALNDLALDPHPEVASMARCIVDVVKKKASSSARPRQVVHTVISQPHSANSSPSNRPANMPYGTSPQNMHSPVGHHNSARKAFEKASSAGTPEDQRNGEDNSIADLVSTKFFEWSCKYFAEPLMCLRREQDPECHSYHEREFRFVRNARVRQQGRDQLRAGVSRLDDQMFVNRVGAVPTAIKFHPYENFLAVADACNVSFWDLEQGTKISDITNPAADKVAMLFNRGSRITSIDFINAHDQALFMYCTDDGAIRIHRDFLSGEVSSKKTLVTAFKGLSELVYSERGSGMVTEWEQETTTLIASGNARIMRLWDMQREKKISDINTGAESCVTSLASDPMGKSLLIAGCGDGSVRLFDRRLNPTECRVMTLREHNSWVLKVHLQRGSEGKIVSACCDGDIRFWDPRFTDSVRVYSTRTALSSVDIHPRADIIACGSTNQCMTAYSPNGSVLSTVKYHEGFLGQRIGNASSMAFHPYLIKLATGSADCFVSIYSTPTGRTSFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVD1</accession>
    <name>A0ABM1VVD1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gastric triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826373.1">
        <property type="nucleotide sequence ID" value="XM_035970480.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860582"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826373.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27150" checksum="8D9B25DB139B5BC0" modified="2025-10-08" version="1">MAYLMRVMRQLSTESIGNVSEDLVSSPMSFIRTFNKDETDEADVGYVLLFSQTELITSKGFPCESYYVLTEDGYILNILRIPHGRNNSDAQSASRPVVVLQHGLLGSCTNFLTNPVNESLAYLLADAGADVWLGNSRGNIYSTNHTHLSPSTREFWNFSWDEMATFDLPATINFVRDKSGADKVYYVGHSQGTTIAFSRLSEDQELASHIKHFIALAPVARVGYAPTPLRKLAPYADQIKVPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVD6</accession>
    <name>A0ABM1VVD6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846292</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826378.1">
        <property type="nucleotide sequence ID" value="XM_035970485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846292"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826378.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24012" checksum="E767B33D04312B95" modified="2025-10-08" version="1">MNLCQSTALNHNFYSTWPLYPSRTQAPELVNLHTLQQHQHHSSSLPDSTSAPPTTASVAMVTCDVQAIRSAQSSVVTQNIVLTVLVLTLFVVSKSYFNRVRRRMARCTVFVIGAGPTGLTSALLACQSPHVSRVVVYEEMPRADLLQKGHQVEFNRKSRDFLSNLGVDFDGLEGCLVGDLFHTRVGVFLEHVLHLLTRGPVSVTLKLGVKFNKERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW65</accession>
    <name>A0ABM1VW65_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium-coupled monocarboxylate transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC118477171</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826657.1">
        <property type="nucleotide sequence ID" value="XM_035970764.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477171"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035826657.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="30911" checksum="12AB0CEC1E163E65" modified="2025-10-08" version="1">MPYFIRHAFADTPGVMGFYVATLFSASLSTVSSGINSLAANTVEDILSGPLSSVKEHRVTQITKLIVCVYGAITVGLAYVANNMKGSVSQMALSVMGATGGPILGVFLVGASVPWINKYGVLGGGCLSIAFSVWIALGNQVYSKKSNNLPFAYTGQCEANITCPLGSDGVTCDTSTLLFTNDTSFHGNYSVEVPTYTTTSPYLTTNGTILDSGDFGFFLYDISYVWYALIGAVVSSVGAMAISFVSRKLVEKKTDPALMFPFSRKLWSMNVSKPTEEETEKSLATKDTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W236</accession>
    <name>A0ABM1W236_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solute carrier family 23 member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828729.1">
        <property type="nucleotide sequence ID" value="XM_035972836.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478714"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828729.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12373" checksum="0DD0B4BC524C74FC" modified="2025-10-08" version="1">MEKGKEEMTNDMTEVNETIQLYNDESSDENVIVKREMPALTYRVEDTPPVMVTLMAAIQHILICFTSALSTASMVADAACVPYDGALRSRIFCTTLFMTGLCTVLQTALGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2D7</accession>
    <name>A0ABM1W2D7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478763</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828830.1">
        <property type="nucleotide sequence ID" value="XM_035972937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478763"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828830.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="52471" checksum="8D998BA0AA08AE3B" modified="2025-10-08" version="1">MTSIKFVKPQNDNKIRNFSLGPEKSLSQQQMSTLNTSTFGGDSENVVHITTPKRKNVHIPLWNLFITSTEPTPHAGEDNSQYKDAHNVADEKSSAPTIPSLEKSNNTQVKSAGAFEDASKMAFFTYDTNENIVHSSKSRSPSRVSEFQRSSSCGVIYGSISSTQQETPTEMLLLASKVSKPSRKCPILNFYANFGQVEVEDKVWDVQDEEVSGLPEVGTPTKLMSPTQPRQSPRDFLGTNNHQPPCNSDAEAALGRAPKGAPKADANEEEEEEGMVEEDAEENKSFFSRHAGTFRRSVSAAALGSFCQPESFFSSINDDKFYELGCSQPAGIDDPIFLTKQYRKARKNAWGKQDRDFDKIEEHHRNNNGGSSDQVASGSKNINTTNKPGSPYSSTLVETFSARYGDAKDHPASERLKRRRFALADPERMIMSQALREKIEKEVEKRKASVTRKVSQFFNVRMGLNREEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W321</accession>
    <name>A0ABM1W321_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Arfaptin-2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101853271</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111391.1">
        <property type="nucleotide sequence ID" value="XM_005111334.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829064.1">
        <property type="nucleotide sequence ID" value="XM_035973171.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853271"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07660">
        <property type="entry name" value="BAR_Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF5">
        <property type="entry name" value="ARFAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="3">
        <location>
            <begin position="162"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829064.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="41577" checksum="4ABE884CA6638ADF" modified="2025-10-08" version="1">MTDLGKPSNPAEDDNFERDLQEMLEDGPSLNDVTANVQGGTPNSVSAAFAETVEPFSAGASSGGGGSGAQAGAGGIYGSSSAGSRLTRSYTVPPATSNVPLSGSGNSASNASGGNSPNGDFVPKSMSLSAQSKIESIREWSVNTFKTTKQFISERFGKGSRTVDLEMEASIESLRDTQKKYANILRLARAMASHFSNVVHTQRALGESFSELAQKSPELQEEFVYNCETQRTLVKNGEILLGALNFFISSVNTLCHKTMEDSLLTVRQYESARLEYDAYRVDFETVQSGPREAATQARLQDSQKKFADHKQKFERLRGDVQIKLKFLEENKVKVMHKQLLLFHNAISAYFSGNATALEATLKQFNIQLKRPNAEKPSWIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3E2</accession>
    <name>A0ABM1W3E2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Retinoid isomerohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829185.1">
        <property type="nucleotide sequence ID" value="XM_035973292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847625"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829185.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="59752" checksum="B831412A058D1F14" modified="2025-10-08" version="1">MSIGLPGYEAAIAITVFATGTGGVVCLSSSPEEQTVDKGKGRIPSWLSGSLYRNGGGIFKMGDTRYRHMFDGLAVLHRWSITDGKVTYLSSILDTDSYKKCVKADRLVGDGVGTSFPDPCRTIFNNFFSYFLPMDGFDNCAVNVVEHGDRLFALTESSLIHEVDGSTLLSQGKVNINKFVAVHLGTAHPHFGRDKSMYYYATSPATSHRAYNIVKVPPPEKGEDLFSKAKIVASIPSRWHLNVGYTHSFGMSENYFIYFELPVATNVPRVLTMKLWSGTIEDCMLNFPDEPIRIHVVRRDTGERLPIQFLAPHGFVFHFINCYEDSGFLICDVCLFNSGSEVKQMYIDNVLEKLEKKIPGDSQFARFVLPLSLDKAKAGENLITLPNVKATAVLRPGTKNTVDVTHHVMFDKSYAFELPRINYDRNALNYRFVYASTVLRKHCPRLLKFDVQTLEVKEWRCEPNHMAGEPVFVKNPSGVEEDDGVILCPVLAETTNESSYLIVLDAGSFKELGRATVPAHLKMSLTFHGDFYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W520</accession>
    <name>A0ABM1W520_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101849275</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829763.1">
        <property type="nucleotide sequence ID" value="XM_035973870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849275"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172:SF4">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829763.1"/>
        </source>
    </evidence>
    <sequence length="703" mass="79800" checksum="605E474246E5B40D" modified="2025-10-08" version="1">MNLKKTKMFKVIATEGRENILKVSREYLRAGKDPNLRDPDTGGNLLHHIIAHSHKFQDPEMLTILYMLACRDVNVDAQDYNGDTALHCAVRTRGAYRIMVALIRCGTDTSITNSTGMTAEDILLQEKPVGHEEMLHWYCKFKPGLWCALREEKPNKRLIEKLLQSWCRLTTVKNGHVINMKVLIQHDMRKMSLLRLLETYENTVELALALIGGLGFIVRQWIKEGILTNISVNTLDLSHQQRYPDYPEAPQPLLAATWETNSFDAVDTLMDLNPDTSVLYACDKALTPKPLVFHLLDSMYRPKETRTVHRILEGADVSVRNSLGQTLLFQAIATEESLETVAILLRKGVNIGARDNLGRTARDFAENLQKPGYIKAIDEQVIQFVKKKDFPQIERLLLEGYDHLTDLKDSHGRSIVDIAKKFSSRQIYEVIRLGDAIQLYVKRVFRAVDEGNHDDLQKLVSCKKYAAGRDVCGRTPLLKAILQRRRGLVMKMVRDCRFTINLQDTMGRTPLHYAYLFLDDPDMIGLLHKNGANPDLEDVRGRRPISYSRSVCGVQTLSQLQRDVLDADLDIFTYKTNFEETFKIAVRAADLVTVKALVKGLGENGDITRYSQLLFDCVDLCREDIAVHLLNSGFRADIWKQYSKCEPTNPLCGMGECSHSMISLKQRAVETGCCRVVKLINQRSENVEALTRQSTSLLNFGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA89</accession>
    <name>A0ABM0JA89_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101853419</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101853419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089040.3">
        <property type="nucleotide sequence ID" value="XM_005088983.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853419"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005089040.3"/>
        </source>
    </evidence>
    <sequence length="268" mass="32079" checksum="3F262B9903F8394B" modified="2025-10-08" version="1">MQKQVKGFYELMLVTGASANHFEESLSLLRNVRENLLPHLELKNYTFIYYDLGLNESQKGEISRKCRCKVLTFPFHLFPEFCSYLKCYTWKPLIVNAHIAQTQLLFWMDASIRFFSNFRKFERLLDRARFRGLQSGLARHHIPHTTMTRTFHFFGDEPCSYLPYRESSSCFWIFHNEYFVRRSVLEPWAACALDDKCMCPLHVVDPKVVRTMCRRREGLYHYGVCHRFDQSAISMIVAKLYQEKYEHILMPNRREYLEIRRGEKLGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBM6</accession>
    <name>A0ABM0JBM6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Exonuclease 3'-5' domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC101850380</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089945.1">
        <property type="nucleotide sequence ID" value="XM_005089888.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089946.1">
        <property type="nucleotide sequence ID" value="XM_005089889.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089947.1">
        <property type="nucleotide sequence ID" value="XM_005089890.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850380"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="5">
        <location>
            <begin position="48"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005089945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089947.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="72324" checksum="B8C814B150484DC0" modified="2025-10-08" version="1">MPSKNEKFYVSVLAMIGAGASMLAVWSLWKSFRRKQEKSKTYIKSKAVHVIDTPQQWDALYPQLVEQLSRQKVLGLDCEWVLKKKVALLQLATTQGLCVLVRLFKFDPVMPQTLVSLLSDKSIIKVGVAVNEDGKKLLQDYGLRVCGCVDLRHMLKRVRGVYTCTSKGLKGLAKGILDLDISKDPHVRCGNWEAEEYSELQRDYAATDAAVAVDIFLQLVYTKLQMTEAASLEGQSGKTESKNKLDESVVSIVIPKEVSDSLLESGMDKRITADESETDSGLRPHTGVEDSQNSIADDLTATSLQNDKLYVINRNSSAENADMEGEMSAAHLDMLWKTGRSMCQGLVDVPFISNTKGGGLPVSKPKGNQKAGPVPAYSMRRRPLWDNCRLLAPDDTPLCTCDVKKAQWYLDKELGDKICDDPLTVRLRFEPANRPDTERNYYLQVKENLCVVCGHDQDYVRKFIIPYEYRKYFPNALKDHSSHDVLLLCTPCHRRSCDFDSALRLQLAQECQAPVEAGATAKTVLDHDLQKIRSAGRALMLNKSSIPEARVTELEKVLKDFYGVESVPEELIKQASDIDARQIAEGYIPHGKLVVRHMARNGGLLAFQARWRQHFIDMMNPQYLPAFWSVDFVPDGWGQRQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDM8</accession>
    <name>A0ABM0JDM8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Restin homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091270.1">
        <property type="nucleotide sequence ID" value="XM_005091213.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848639"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091270.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="45771" checksum="13C8E08379E4F742" modified="2025-10-08" version="1">MEKGQNPSRVPRESVHEQDERLTSKHIQTLGFLQEIVNENKELKTRVIELEESLEECKDLHAFAKQSKEKIKDIQESYMARADEMNSMLAEKHRVEMMQVENEKLEIERELKEQILKMRHDIDSLNAANKDLRDTAAEDENSSEAKTKLKEVMKQMQTYKQENEELKEELEGIRSDLEIIQSKRSTDMTQVRELRAENKQLSETVQEVQQKNNELEFRLDKALSDLREKADDQEQTNLIENLRDKVRQLTLDREAGVERETQMGQDLLDLSALKDELKHANAHLQRELEKLLTEYGHLLAEYERLRKRSMKEKDNKTFKDFVSLKRELRSVRHENETLKHGGKNDGLTVLRDDPPPLPVEQPKKKNALDGKRIGAKKMLAITLNRPTATSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDP5</accession>
    <name>A0ABM0JDP5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">dTDP-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091290.1">
        <property type="nucleotide sequence ID" value="XM_005091233.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852899"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF23">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091290.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36084" checksum="5A32530B89CB425B" modified="2025-10-08" version="1">MSNGSLINGCNGNNKDLPPSPGHILVTGGAGYIGSTLVPMLLEKGYEVTVYDQFLWGISPLLPVAEHPRMNIVKGDIMDKESLAQVMEGKTGVVHLAAIVGYPACDKDKPKAQQVNVEGTRNITELKKPDQALVYASTGSCYGAVDGVCTEETKISPLSLYGSSKAGGEELVLAVNGTALRLATVFGISPRMRLDLLVNDLTYKALTIKHFDLYEGHFRRTFLHVRDAARAFLFAIENTKVMSGQAYNVGDERMNLTKNDVAAAIQNRVPTCKIIPSAVGEDKDKRDYEVSYEKIKKLGFRSTVSVDEGIIHLLKILPNMLDLEIARSKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFI2</accession>
    <name>A0ABM0JFI2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092499.3">
        <property type="nucleotide sequence ID" value="XM_005092442.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848803"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="274"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005092499.3"/>
        </source>
    </evidence>
    <sequence length="394" mass="44550" checksum="C58C333F9C2E13E7" modified="2025-10-08" version="1">MAARPLISVHSEKGEATATNIALPAVFKAPIRPDIVNAVHFQMLKNTRQPYAVSEKAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRINVNQRRYAITSAIAATGVPALVMSKGHRIEEIPEVPLVVNDKVEEIKKTKEAVAVLKKLKAWSDIEKVYNSKRFRAGKGKMRNRRRIQRRGPLVIYNQDNGITRAFRNIPGVTLISVDRLNLLKVAPGGHVGRFCIWTESAFKRLDSIYGTWKKEATEKKGYNLPMHKMASFDLARLLKSDEIQSVIREPKKEVRRRILKKNPLKNYRVMVRLNPYAKHAKKQAAHIETTRKRAKEELLNKKRGITKPLEPLPKGKAAKRKAKKQAKRAGAKKTTKPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG59</accession>
    <name>A0ABM0JG59_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850542</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092934.2">
        <property type="nucleotide sequence ID" value="XM_005092877.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850542"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092934.2"/>
        </source>
    </evidence>
    <sequence length="494" mass="54823" checksum="EAC8EC5863779374" modified="2025-10-08" version="1">MGNQKSTQPLLQETSIQKGSARESSRVPSAVLQGEVATLNQGIHCEMALLPCDDVINEGVCDIMYRRCKKNPGHLLFTPVAELTLEDLPVESRHPNILVQIKQLAFSVVRLRTNYTSTHRPDRFGLPSLKGTRKLRFGSGCILSNLSELSVSKESKLVVEISTAAHVVFDDDEAKSTRVECFLQSDTDFTSVANGKGVRIVHVNVDHDFCIFECEFAQSKQLLQFCSSVKKAKEDCKTNIWPFVNNPLTFSISHPHGTAQRISFGSQLQRNSLIASEVTVNVMKIFSSRVWQKLHVDLKKIWHFIVCELCLKDFQLPLSSTLKGKDLASIVAHLVSKELITHPLETESEQLKGIYKALVKEIAKVIVLRLVSGQGSTCNVDKKKVRQTASYEAMRAEIVSEMASRVHLVPDFEGTLERIHFAITSETVKEITGLHLPATFCLLRGMDYAVPTCPGSSGAPVFTVNTREMAMVNHSRAREKLGSGGVGLFVKFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG89</accession>
    <name>A0ABM0JG89_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101845304</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101845304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092996.2">
        <property type="nucleotide sequence ID" value="XM_005092939.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845304"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.532.10">
        <property type="entry name" value="STAT transcription factor, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036535">
        <property type="entry name" value="STAT_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="776"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1047"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="817"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092996.2"/>
        </source>
    </evidence>
    <sequence length="1181" mass="131587" checksum="A3B6D867A7B34F9B" modified="2025-10-08" version="1">MEWSRVRRFLVMMIQGKVEGTEELYDKIPFFLRTRLHDFIDNVQWAHISQECQKNNPTEINNAQLYYVKILALMEQFIENERNSPSQSDSGVMMTFARYSVKNTFQDDGVLFATEMSTCLQKEKELLYLHSANYEQEANNIPFAPDNYMLPEISDTFSVIKGLQRDVEQAKICIQSISEEFGEESSDLPSMLPDQLLNAKNVLEGAAIDATWDEQMEVVAAKASLQWTEATINSHIESMIANDAESHEMRQRVMRILQRTVEQLDQLLSGLEKEVSEWREAEARASVKTGPDISPVVVNQNFKEFAHLLEALDRVFHKMHESPGMSAGSSSFPGQLAALHRSFKLAENRFFSSALVVSIQLKDVIDIANKGSKDSDADKESKKEMKFCSNKNQNLHTEVRILGGESFSGLNITDSNIELVAERDLVRMESDVKQEGGKKFLKLPPGKVLASGLMVSIEWKDIEVQNFSRVEQNTVYKQFFRMRYSVTVEVHGTEYRLETLSLPFMFKTGSNQLLEFIGARMWYCSNADLYKGSFECPNSLPVEDVINMLNNRITFATSKKRQLTSEDKAFLRNRLTVNEEGQVSMQGFIKPNQEGAKSSKKSGAETNPSFYSWFHGVVGSIERYLLKPWEDGIIYGFCSPADVERKLMSDHVPEGTILFRPSANKLESAASKKATTALIMAVKTRNESSYAVMSVPLYGDFIEKNGFYKSVRNIKDEKNQRIAKFLYGCGERNRSIVEALEKYGKEERESKYYYDYKLMVKKVETLSVRFCNSKVEASSDGTSDTDEQGRPGAKKRRYPSINSSKPFSPSSTSSQSGTFPTASPDSSGPTFSGTFQSTSHEGSSTGSPVLKSEPSTPVSACPENTPRAECGVVDGSDATSLASPDPERVPVSSKSLPVSQNLQVFGNVQVDLSNIPPAYTEEVQVVTTQQFPVQTRGKTLSTAQGMEGRTQIPQNLNQTQFSPPPMSVPPSVYPAGINAFDLNTVGMSIGNFSVQFIDQNGVMISEMTTMPDQGEMATTVFMSQGNTAVQRGASGSVLGNVPTVLAEAKEQTPHRRRSRKQLPTCQATSRNLTQVPYLNIQSQNATDNSANNLYSTSSPLQIGDPNMMTTLDANTILQLLSAQNNSNTGNLEIISELNDPATVNELLNEQLATELQMSDIVEYLKETETEEDSRSPDSGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH55</accession>
    <name>A0ABM0JH55_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">TBC1 domain family member 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101855325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093564.1">
        <property type="nucleotide sequence ID" value="XM_005093507.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093565.1">
        <property type="nucleotide sequence ID" value="XM_005093508.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855325"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="101"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005093564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005093565.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="49022" checksum="3454257C23B5075A" modified="2025-10-08" version="1">MDSVSDDESSEVIEESSTVEPTPTSTDSNLRPTSPRHRLLDPEPPRSSQEDEDGFFRVPDDDVVPSSYVEKNKVVAIEKALASDPVDIMALKNLAISRGGLVNKSLRQRVWPLLICANTNNVTPKPSQEEMEACSKTYNQVVMDVNRSSSRFPPGIDDTVRMAVKDKLVDLIMRVMLKNKQLKYYQGFHDVCITFLLCMDEDLAFAMVEKLAMSYMREYLDDTMERTSLLLNTIYPLVNKCNPELCEHMQRNDLGTIFALSWVITWFSHVLGDIKRIMRVFDFFLASHRMMPVYLSAAFVLYREQDIFDAGDEMGYIHKCLSTMPSDLPIEYLLERAGDLYLQYPPTEISRDPMLIRLNREVFEHFNRIDSQNARRLARANSDARGRLFVRMTMWTVTAVIGVAIAVLYHAYSENDWHHLGALSPFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHX9</accession>
    <name>A0ABM0JHX9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Cysteine sulfinic acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11 12 13 14" type="primary">LOC101860963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094033.1">
        <property type="nucleotide sequence ID" value="XM_005093976.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094034.1">
        <property type="nucleotide sequence ID" value="XM_005093977.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094038.1">
        <property type="nucleotide sequence ID" value="XM_005093981.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094039.1">
        <property type="nucleotide sequence ID" value="XM_005093982.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094041.1">
        <property type="nucleotide sequence ID" value="XM_005093984.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094045.1">
        <property type="nucleotide sequence ID" value="XM_005093988.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012935522.1">
        <property type="nucleotide sequence ID" value="XM_013080068.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860963"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005094033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005094034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005094038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005094041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005094045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012935522.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="60380" checksum="4E7D179E58B6AF08" modified="2025-10-08" version="1">MLSHVARSLLRTTASRLPLPGVDSAVHVLGANHSLRNVVISFKRTMAAEPFKSFSDPEVSKFLDDAYKLIKEDVLQKGTDGSVPVLQFQHPQELMDLLPLDISSGPVSHDTLLDGMKSIIKYSVKTGHPHFYNQLFGGLDPYSQAGSWLSESLNSNIHTFEVSPVFIVMEKYLFKKMCDIIGFENGDGIFCPGGSASNVMALQVARYKKFPQVKTEGIYGLPKLRCYISEDGHYSLKKAAGYLGLGSDNVVPVKTDEQGRILTDDLEQKIQEDLQKGYAPLFLMATSGSTVLGSFDDLTALSKVCRQHGIWLHADACWGGGTLLSKKHRHLMDGVHLCDSVAWNFHKIYGTPVQCSALLINDQKILLDANSSKAEYLFQPDKCYDVSYDVGDKTVQCGRKVDVVKLWLQWKAFGDSGFEARVDRAFDNVRYLQEKVKTTEGFRLIMPEFQFVNACFWYIPPRLRGQEETKEWWAEVGKVAPKVKERMVKAGTMMINYQPLSSKGLVNFFRLIVHNPSNTYKDMDFIISEIDRLGWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIF2</accession>
    <name>A0ABM0JIF2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 3A11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101853375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094361.2">
        <property type="nucleotide sequence ID" value="XM_005094304.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853375"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005094361.2"/>
        </source>
    </evidence>
    <sequence length="517" mass="59132" checksum="05D3E9F087041C5B" modified="2025-10-08" version="1">MELSILTIFLLCCVASLLLYVWYMSKDHGLFRKLGLPGPTPWPVVGNMMQEMGGAGLFDFHVKMYKKYKKNKVYGVFRAKQPALIVCDLDMIRDICVKHFNNFVNRQTFDVEPPLGNSLLELKDDHWKTVRATVSPSFSTTKLRKMYPHIVRNTQLLLEHLKEKHERNEPVELRDLLSAYTMDMIASTGFGVEINSLKEGENEFTKSGKALLGSFGRFIFLAMFVNFLRPVFKFLGITLMPKDATEFFTRFIDKALESRKHEKGGGSGRSDFIQIMLDAEHEDHTEHGNHAVNEEQENGHNTETKKVLSYSDIQGQAFVFFLAGYDTVATVLSFTMFLICMNPECLKKAQEEVDKVLEGKFPDYDSVQSLPYIEMCMNEAMRMYPPGFILDRICDKEIEIQGIKIPAGMNVTFPVHAIHHDPELWSEPEKFDPERFTPENKAERHPYAFLPFGQGPRNCIGMRLGLLEVKVAVAAMLQTLSPVPCEKTVYPFTQEKLQVKAVEGLWIKFEPRKKLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIW6</accession>
    <name>A0ABM0JIW6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101851935</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094702.1">
        <property type="nucleotide sequence ID" value="XM_005094645.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851935"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094702.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="67696" checksum="6FC2EDD9C230C494" modified="2025-10-08" version="1">MKQIPTALDLDHVSRLFSLFRRRRVLTSTAGFSSHQCQLRVLMSNSVKTLSSFQLLHQNESSNKSKRSGIFGRQCQIRDPVNSDIQQNETKEVDRGWCCNDVTLSMKKVQVLYHFISSRNIPRLYAHIHTFYDCFNNIRVETNLSVDFHARGLGVNKELISPSVDRKHLDLDLCHVDGCNYVIVKKLCFGNGRKLSCQNIFNVRASQSLLCFRFWTIRHISGSLNKNHFFVNRAFSSSSSGDKNAVFNDLMSLVQQSEKSMKAPQLSPRVKNKQQASSKSTKYIKQMLPHLISPLDNDSEAPAFESVEKHLMSLMEMWEMEKAVLALRGAVEVGVIPDQTVVLDLLQQLANLGEVECLLEVHAFLKDHGLTTNQRFYQSLRDAYFNSGRIEEGVGMLRIVYHGTRDFEDADMFFTLLCTMTLKHFDHRRDLIEQFIKDLEEAEPPITAPRASLWRCFVLAEKFSEADSLLEQYPELQKKLPSQVTKIINSALRMDYDREAVYEWLIQLSSIKPGLRASVFDSLVQYKSKEGEWTQVLEQLTTAMDMGMKIHPHTVTNFLTQFFSQLPSITVEQLSEWARGLEEVQDNGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJJ6</accession>
    <name>A0ABM0JJJ6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101851337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095138.1">
        <property type="nucleotide sequence ID" value="XM_005095081.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851337"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005095138.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10275" checksum="AF335DAFAAB17E55" modified="2025-10-08" version="1">MSERKAVIKNADMSEDVQQDAVDCATQALEKYNIEKDIAAFIKKEFDKKYNPTWHCIVGRNFGSYVTHETKNFIYFYLGQVAILLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKD3</accession>
    <name>A0ABM0JKD3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095757.1">
        <property type="nucleotide sequence ID" value="XM_005095700.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858017"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005095757.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14104" checksum="E82F3BEC6FEB52BE" modified="2025-10-08" version="1">MSSITTKATTRRLDEDFAHFGYPHAIVTDNTTCFSSAEFQTWCEQRGIQHLHGAPLHPETNGAAERLVQTFKQSLEKSDLPPADALREFLMHYRRTPLASGSSPSQLLNGRQIRTTLGVIIPAQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKQ8</accession>
    <name>A0ABM0JKQ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KRAB-A domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096011.1">
        <property type="nucleotide sequence ID" value="XM_005095954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860161"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096011.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="32985" checksum="C299483609792FF1" modified="2025-10-08" version="1">MPKETKTADDEGCCRSSNTHQGVLAKGQVDLIDMRSMQSGSNKKWMMVYQDHLTKFCILRALTSKRAAGVAFHLLDIFLLNGARVILKSNNRSEFTSQVITELKKVWPNLKMVDGKPRHPQSQGSVERANGDIKDMLVAWKADNDSQDWLTGIKFVHFQKNSSLHSGTKCSPYSAMFGCEARVGLTTSSLPEEVIARIETEEDFLAVNENPLSLSLTDGAANQIQTASDETPTVSVTDGVLLPVQLESTSAQDIDLSTGPSLPTATPSVYDVDCPGSYGQSEDHVTSLLPSPSDSPGPLLKTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLE7</accession>
    <name>A0ABM0JLE7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynactin subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096449.1">
        <property type="nucleotide sequence ID" value="XM_005096392.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861117"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="59"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096449.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33224" checksum="AA470078142D2728" modified="2025-10-08" version="1">MSVIAPMPINKKESECSCAPCKRFFKAALKEGSECIRQTSSARADGTAVLGNQSGLVRKGDRVVVHGKHAGVVKYVGLADDHIIAPEMHVGVHLYDNVYSTHNGVYKGKRFFFCPRGHGAMVKYSEISQLNPIPQTRPVLGNPMFPSYEAVKKRRKDRQQKIHEAEEKLRKEYEAKRRAQIERYSKSVPSPRISPRSTKASQLRMGQGEEKPRQPLQDEYDIAYRDYLNRQRRNQERLAFSESPEQIQLRQMKKVFGGDEKAQRMAETLRKLHQAYEEGKIVAMAERDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQP0</accession>
    <name>A0ABM0JQP0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862874</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099279.1">
        <property type="nucleotide sequence ID" value="XM_005099222.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862874"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099279.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48882" checksum="487A30B2391CCC6F" modified="2025-10-08" version="1">MTVGWKTLDVGEKALIYSKDGSYRVEEGPQRIFLFRETFRSMSSYSASQKEYLVVKFKDGRVQNLRGPCTAHFNEVIHLSIKVKDMVSLSANEALVVYKQDDATKNVLRDVLLGPSLIMLNENEWLHSFCWHGTDPNNKTRMVRGIDQFTVLKIIPDQFYYNVDEVRTADDALLRVKLMMFYELTDIEEMLNTTKDPIADFINCLCADVITFASKKTYEEFIETASELNDLKNFPQLTERCAVIGYVVTKVAFRGYFAHDKLQKMHDMMSKKRTELQMKYEKEVQEQSLKDLKLEAEIERLEQEQELELQKLIHNQKMEIDSLKHKLELEKTSRLRLIEEKTLEDKAKLNAQIAKEQLEAEHLHSLHGLGVNITDLLVSRAGRPEKVTSIVASKGGAAVHIHHNDLALSGNVLRTGETAKPSETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR13</accession>
    <name>A0ABM0JR13_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101855564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099510.1">
        <property type="nucleotide sequence ID" value="XM_005099453.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855564"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="599"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="641"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="810"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005099510.1"/>
        </source>
    </evidence>
    <sequence length="941" mass="105154" checksum="5F5C58FD01C3B176" modified="2025-10-08" version="1">MGVTKQYLRVAPGPVFGVVASQKSNILALPGDASRSVRCAVGACENVYIWDLVKKEKVLSLLGAKSEVSCLAKSPKTDDLAVGYYDGTIRIFSLSTGQSDVTFQGHKSAVTALSYDANGLRLVSGAKDTDVILWDVVSESGLFRLKGHRKEITKVTFLKNRDLLVTSSKDGYIKFWDLGTQHCFYTVVGHRAEVYGFVLLRDETRLVSGSVDSELRVWDIHYLTAEEQEDMKMDTSSGPVAKKRKLEGGLTETDEGQEDDESDDERTEEEKANDEAMRILTCKKVGSVMRQGRERVVCLTSDPEEKLLLCHGTDKHLEVFELPTEEGLNKLRAKRIKKLRKRHLDSGEDVDTASVTIKLQDEIKRLDRFRFSAKLWSVHACYDHNKELRICALLADNRLDIAVLQHANHKAELSEVSSLSQAGHRTEVRALSVSLDNATILSASAEEVKLWNRDSLQCIRTMSCEYALCSLFVTGDRHAVIGTKSGKLQLFDTSQGKLLETVEAHTGAVWSIAPMPDKRGLVSGGADHEVKFWNYELTSDPTQTVQHKVLTLEHTRTLKMDEDVLGVKFSPDHRLLAVALLDNTVKVFFADTLKFFLSLYGHKLPVTSMDISSDSTLIITGSADRNIKIWGLDFGDCHKSIFAHDESVTCVRFVPKTHLFFSGGKDRKVKQWDADNFENILTLEGHHGEVRSLALSPSGNTLVSSSHDRSLRLWEKTEEPLVLEEEREMEREEEESESLLKDGEEVVPGETTEEVKMAGKKTMDTVKGTERIMEALEIYESQIAEQTQAAGGKAPAPHPMMVAYRCETPSDFVLETLRRVKPSDLIGSLLSLPFSFVTKLLPILDELLSGRRNTELVCKCLNFLLKIHHGEITSSRAHIAVVEKLKEHSVTAVQWQRDVTAFNLAGLSFLKKQLEESKSVTLFADATSKRKKKKRAMLAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRA1</accession>
    <name>A0ABM0JRA1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC101859019</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:43816"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43817"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:43818"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099690.1">
        <property type="nucleotide sequence ID" value="XM_005099633.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825995.1">
        <property type="nucleotide sequence ID" value="XM_035970102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859019"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="69"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005099690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035825995.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="31093" checksum="E270A2EC99CD9414" modified="2025-10-08" version="1">MPLKEGSWQMPPMKKGYRVPWLWKLSTRFAVTTVGFTCKFWLEWLNKARFHNREILHDMFDKTPDNRGLLTVSNHSSCIDDPLMWGALKARQIANTKRMRYSSAAEDVCFKGSNLLSTFFSLGKVFPIVRGDGVYQKGMDYMVDQLDLGNWCHIFPEGKINMTNEFLRLKWGVGRAVADCQRTPIVLPIWHVGMDSVLPNSRPYIPQIRKHVTILIGEPLDFSSDLERLRSMKKTPKEIRKHITDKIQEEFKSLKVLAEAFHKEFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRD1</accession>
    <name>A0ABM0JRD1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101853323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005099746.1">
        <property type="nucleotide sequence ID" value="XM_005099689.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853323"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="72"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005099746.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26658" checksum="9FAEE415CA0EC54B" modified="2025-10-08" version="1">MPAAPQPASRDESNGINAILLGPPGSGKGTQAPMLAEKYCVCHLSTGDMLRAVVASGSELGQRIKGVMDAGQLVTDELVLEMVNSNLDKPECRNGFLLDGFPRTIPQAEKLDDLLEKRKSPLDSVVEFSIDDSLLVRRITGRLFHIKSGRSYHEEFNPPKVSMTDDITGEPLVRRSDDNAEALKKRLDSYHRQTKPLVDYYSKRDLHVAVDAAQPPKVVFSAIQCIFSAAKSKDQVYFMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRY6</accession>
    <name>A0ABM0JRY6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100158.1">
        <property type="nucleotide sequence ID" value="XM_005100101.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850088"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100158.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11536" checksum="D9C36D46899A5501" modified="2025-10-08" version="1">MRVIETKEEFDNLISSEKKLVVIDFFATWCGPCKVIAPFLEKLSEKYPDVVIVKIDVDENADTAEECDVTAMPTIQLFRDGSKVQEVIGANQSKIEEAIVANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS39</accession>
    <name>A0ABM0JS39_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100259.1">
        <property type="nucleotide sequence ID" value="XM_005100202.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854871"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045985173" evidence="1">
        <location>
            <begin position="21"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100259.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23579" checksum="15A1A0FC312AEC68" modified="2025-10-08" version="1">MNRVLFGALLIWIACGLSCGTPSFCYDKSILINKFRVCIEDAGMLQYYDFSSGQPMVKDNDYRQFCNNTEGFVTATDCSLQIMKQCLPPTATNLLPGKAFQTRMISSICNDSTLKQDCFAVAQTKQTDITYCVKRAMNPNSDDLACDAMKASQTCTFQEMRPCDEHTAQFYSSMLQPEVDRVCNGAARILTDTGLLPFLLSILAVWLKSGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSD9</accession>
    <name>A0ABM0JSD9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM221B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM221 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100430.1">
        <property type="nucleotide sequence ID" value="XM_005100373.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854336"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026755">
        <property type="entry name" value="Fam221a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214">
        <property type="entry name" value="PROTEIN FAM221A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214:SF3">
        <property type="entry name" value="PROTEIN FAM221B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14753">
        <property type="entry name" value="FAM221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100430.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="39825" checksum="03D3E95E22402844" modified="2025-10-08" version="1">MKKGSGGGAVPKETGKTKSGSSSRSSGLPHGNAAPAKKTGAARPTGERSSKAPVPKGQQALMQKLQDAQMPIKKVNGMYVPEGYRMREIKPAKNYDVVSMAKAMNDDFAPKLKELFDTETAAAIEAQKTGIYIGWRCPEFQHDCQRVFHTSRCFCDHALSEHAQYNALSVKVPCRIPGCNCKAFEWIPNRPEDIGEFWLPKRPGFDAAAWRAKCKCKHTHNFHDVQRPHRCKSKGCGCSTFWSDFLCAACDRHWEDHQTFFDSEQSRREQGLPVGTDWLPFAEMPDLRNIALSGNEEDDSKYLALREYDAIPANAVTGNNEVVNFGGGRNPGTSRDFGGRGGRFGGAAGGGGGGRSGFRPVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTH4</accession>
    <name>A0ABM0JTH4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101852861</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101099.1">
        <property type="nucleotide sequence ID" value="XM_005101042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852861"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101099.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13427" checksum="C955B40113098774" modified="2025-10-08" version="1">MSIDDHTKPRVNGSLLPNFHGKQVCLLGVAKDVDSGGNFFTLTTCDNQDIRIQMQEPLRERVSGLTEVTGTVRSKTSLEAENVVVFSEEASANFDASLYQKAIEVSQRHPNFYIQSGHIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTJ8</accession>
    <name>A0ABM0JTJ8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit</fullName>
            <shortName evidence="9">Oligosaccharyl transferase 48 kDa subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101846218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101160.1">
        <property type="nucleotide sequence ID" value="XM_005101103.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846218"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044988474" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit" evidence="9">
        <location>
            <begin position="19"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="10">
        <location>
            <begin position="23"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="11">
        <location>
            <begin position="289"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005101160.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48358" checksum="7E5EC334DA92BEDA" modified="2025-10-08" version="1">MAALKLAALLCFVAVCYASSGKRTLVLVDNWSIRETHSVFFRSLREQGFDLTFKTADDSALALVKYGEFLYDNLVLFSPSVEEFGGSIDVASITNFIDGGGNVLIAASSDIGDPMRELATECGVEFDEEKSAVIDHLNYDVADDGKHTLIVADSDNLMKAPMIVGDKVPAPLLFRGVGMVSDPDNPLVLSLLRASSTAYSYKPDEKIDEFPMAVGSSTLLVAALQARNNARVVFVGSLDFFSDQFFQSSVQKANGGKRFEKSGNQDLALSLSQWTFRDKGVLRVGKVSHHLKGEKVPPPSYTVFQDVDYSVVIEELVNGQWKPFKADDVQLEFVRIDPFVRTTLKARDGKFSTTFKLPDVYGVYQFKVDYNRVGYTRLYSATQVSVRPLEHTQYERFIPSAFPYYASAFSMMLGVFLLSFVFLHYKEDTKDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTK3</accession>
    <name>A0ABM0JTK3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Y+L amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005101169.2">
        <property type="nucleotide sequence ID" value="XM_005101112.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848363"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF375">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005101169.2"/>
        </source>
    </evidence>
    <sequence length="611" mass="64982" checksum="E45DAAC4CDFEBF1A" modified="2025-10-08" version="1">MTGKGSKGDPVVVSMSRLQGQDNPTYVHNDEDSVSTVPNHPSPTTGDPATRISIISDPSSSQGIVRRKGNNVTGGSAFPNDSLDVTPSTLTSGHILPKQNAAGLRNGGASAVPNGHGSGGGGGGGGGGGGGGGDGASPPAAQSQTSTIQMKRSINLLYMTAIMVAVTGHSSIFVSPSSILSQTGSVGGALIVWLVGGLINLGMALCFAELGTMFAQAGGPYAYASKAFGPLMGFLMMWGYTVLIAGPFWAFLAYTAALYIVRPIFGGCMPENVNTAVNLLAGWIMVTMVVLNCVYMKYVTKVQTLLSASKILALLIIIAAGFYNLGKGKTENFENIFEGTTTEPGKFALAIFYSVFSYGGWQVMTTMLEEVKDPARDPPRSVYISFAVVITKYILTNVAYSTLLTPAEIVGSSAVASLFIERLYSPLSALISVFVALTSIGALNASIMGHSRLLFAGARNGHMPQILGMIHTKYLTPWPSIFVYLAWGMVMLFTGGVVDMMEFISLFSTIMGIVVIAALLYLRWKQPDLNRPYQTMTFIPVVELIVNVVVLVLGINQKPHKMGIGLAILFAGIPVYWFGVLWKNKPREFTNIVDELTAFAQKLFLLTKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU51</accession>
    <name>A0ABM0JU51_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9" type="primary">LOC101857887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101551.1">
        <property type="nucleotide sequence ID" value="XM_005101494.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101552.1">
        <property type="nucleotide sequence ID" value="XM_005101495.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939780.1">
        <property type="nucleotide sequence ID" value="XM_013084326.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939781.1">
        <property type="nucleotide sequence ID" value="XM_013084327.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857887"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005101551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012939781.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21028" checksum="BCD3C511F34C15A7" modified="2025-10-08" version="1">MHKTTFHTSTGDVLFFPEWVLHGRKETYLTCIVLVILGVCYQAIKFARQQYGRKCKNLECKRYILNKGHMLQTLMYLLQFVWGYVIMLSVMTFNVWILVAVLVGFGIGYFFFGWGEYEEPSAAMRVYRVPVTKSYIANSCSDRVTASSSMTQELLPLSESTDETIFRESRSDSVLCSCDNSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUB4</accession>
    <name>A0ABM0JUB4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101847269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101671.1">
        <property type="nucleotide sequence ID" value="XM_005101614.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847269"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="154"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005101671.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26213" checksum="86DECB0E9BAECD19" modified="2025-10-08" version="1">MADKRVGNVFMPGDVLEDLQVSESVKKIVLGPGLIDDGNRIKISKPGILRFREPGIYWIDCHQKRYVPSKGDSVIGIITQKAGDIFRVDIGGSEQASLSYLSFEGATKRNRPDVKVGDIVYAKLLVANKDMEPEVVCIDSYGRSSGMGVIRNGGFLFNASLNLVRKLLSPQCALVKSLGHRFQFELAVGLNGRVWAKSKSDIQTIAMANGIMASEFMDNNQIKAMCKRLSRAVSGMEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUL2</accession>
    <name>A0ABM0JUL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Toll-like receptor Tollo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101852187</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101868.1">
        <property type="nucleotide sequence ID" value="XM_005101811.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852187"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045587853" evidence="13">
        <location>
            <begin position="31"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="14">
        <location>
            <begin position="1079"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1225"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1413"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1238"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005101868.1"/>
        </source>
    </evidence>
    <sequence length="1444" mass="163862" checksum="299B857AC5E1E818" modified="2025-10-08" version="1">MAAGVSITRTMLLPLGVFLLLSFPVIGSSALSAPALSLRDQWAVAVNDGPTYNGSDVEDLVCPTDDCACYIMNGKRLIWMDCPVSHVSTRLQLLISFFRPRHTGYLEFTCTYSVLQPADTAPTSELWDGAFQDLSSLTGLSFRNCRFETLSRDAFRGLVSLKELYIQGAVIQTLDSALLTHLPRLQKLEISGSGVTRMFPLCTSSPLRILNVTGNHLTRVENAGVWCPDQPLIHLEVLDLNNNFIESVPRWLPQAMPNLHHLGIADNYITKSEKSSFKNLPKLAFLDVSNNSLPRLHPTYFEGCGNLLALGLSGNKVYALPQGLLSNLSHLRQLEIAEMGLDDRVWLEMTELRQLRQLNASYNVLTSFSVDIMSQFLLLESLYLNHNRLSAFPGDTFLYLFRIQILDLSFNDLYAIPDLAFTNQPELQYLLLHHNNISRIGLKAFTSLQGVLEVDLSDNLISYIPSETFVPMEMLRKLNISSNNIGVLDKGIFSENFDLQFLNMSHNVLKTIPALSKLRDLEIVDISYNNISYLDPETFIGLKELSHVYMDHNNLTSLPVKLFQGCDKVIHLNLSHNSIQRLDELLFSSTLSVDVIDFSYNEITDVTRVFSGLKRLNSLNLAHNKITKIHRGQFPPSVVDLDLSNNHISTISAHTFKSMSSLKRVDLRLNRLTSISKMAVEVAFNLPYEPTFLINYNPLVCNCHLGWLKDWSDGRLKDIVPLPNFKLSLNLHCQSQFYSPSVLQRVPREEFLCNYTNYCEDSCVCCDYDACYCKYTCPSACTCFLGDDYLQVHHVLCNSASLTAVPPSLPEGATNLRLDGNNIQTLRRHTFLALKHVTTLYLNHSQINTIQNHTFKGLKSVRVLYLNDNFLSAVYSVTFKGLENLEELHLENNDIFFIDSQALLSPEPLRYVNVQGNSLVTISLEDITIFANRTTEGEPPARLFLSGNPWSCDLEFVKPFLKFLLSFSNSVMDISFIECLTSSTEKPGMAQPTGRLLLDFQKYLETENLTATSNLTSSGEHAPDSNVETYALIAACIIVAFLIVLLIVIYFNRHLLQVLCFTRFGCRMFKMAKASDDDRPYDAFISYSNKDEDFVIRQLAPRLENGDKKFRLCLHYRDVTVGACIAETIVRSVEASKRTILVVSDNFLDSEWCRFEFQTAHQQVLDERRNRVILVLMHELDSDKLDGTLKMYMRARTYLKYDDPWFWEKLMFAMPDIRYRTKQTEQLHHHHHLHNHLLDQQQQQQQQQQQFHQPARLPSSRELEYLARTLSQLHRDNLTPQQQQQQQQEQLQQQQVQQQQQQQPQQPQQLPASMLTKQQCVEGSGGSVRCPEGAIHNDMYEIPVLDSQSMTYQLANGCGCAITHTNTAYRHSDCNCSDSTSGYHNGSMDGSACVHYEEVGPPVWSSLQTTPNRQLLTGETPPPPLPSIPKEGLLPKDRIMTLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUQ7</accession>
    <name>A0ABM0JUQ7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aurora kinase</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101853470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005101959.1">
        <property type="nucleotide sequence ID" value="XM_005101902.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853470"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="64"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005101959.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37282" checksum="0A20213A5DF73A79" modified="2025-10-08" version="1">MDPASRVLKPNLTSGTTAAHVDSLAAAKLPLRVPAEKENNSSGGDIASSSDSSNGPVKWGLSNFDIGRPLGKGKFGNVYLAREKRSKYIVALKLMFKSQLVKAGVEHQLRREIEIQTHLRHPNILKLFGYFHDESRVYLILEYAPKGELYKDLQRQKRFDDARSSKYIAQLADALIYCHAKKVIHRDIKPENILLGLKGDVKIADFGWSVHAPSSRRQTMCGTLDYLPPEMVEGKYHNECVDLWSLGVLCYEFLVGNPPFEAEGHNETYRRIVKVDLVFPDHVSDGARDLISKLLRHDPKARLPLEQVLKHPWILKYNPDLASSSTSSAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVI5</accession>
    <name>A0ABM0JVI5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein LOC101862360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC101862360</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102525.1">
        <property type="nucleotide sequence ID" value="XM_005102468.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005102528.1">
        <property type="nucleotide sequence ID" value="XM_005102471.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862360"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005102525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102528.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40680" checksum="954108C5255327FF" modified="2025-10-08" version="1">MGNIIPNFFGSWEPYQNVECQNAWAGCDASEAGAPITGGKLVNGKLTRRRGDHEVDERCVEVGGPLSSMSSCTKHPGHTDFIPVPEFGLRHLPRPYRNKLVLDFLKACANLVVRLHLGFISDGRPEKWPGTEDRYPFAVHRGTDLVSNVGSGWVSRVRPCWEEHGLCRCATCREMEDEGKERRWWEVLIVTARHVVFDSVEAKMCEVTLFDDHKDGSGSVVLMAYEMGLGHTEEDFCFVMCATHDPKVAERLQEMMDERETLSDMIVQQYQHVDDIPTNTVVISHPHGRMKYVSVGEFKGLEKMGDKWIYSFRHTAATCPGSSGGVVLPLIGWWRGLFRAAPHNFALTSSENLSGRWGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVZ1</accession>
    <name>A0ABM0JVZ1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101862050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="10">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.1.3.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005102791.2">
        <property type="nucleotide sequence ID" value="XM_005102734.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862050"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="11">
        <location>
            <begin position="8"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005102791.2"/>
        </source>
    </evidence>
    <sequence length="409" mass="44987" checksum="EAA83390445B182E" modified="2025-10-08" version="1">MAESVTIERLLTLIQATEDLCKTSGPDQPETGTFLSILHRLKSEVANNDDIIPFVDSLSDVRIWNEEINHLKAERGGSKLKLDETASPWAESYIIRKLASLCRGENISEEDLIGIKSESFLTSHYRLLSKISMHLVTSLDADDEGDEAKGNGFLGAVGDALQFCAWARCLADKFSSQQEVGGIKEELAILRRHLLANEATKVLDFLKQGEDGTVKEEKVAESSGRSLRRVDIVVGGVGIELFLDLCLADLVLAAGLANSVTFHLSAVPEVVSMATETDLRTMVKALMAVNHIGLSQCHGRWKKRLQDGSWQLRSDVYWTLPFSYLDMASGAPELYQQLTTSRLVIFRGDQHYRKLVGAAENVSNYAKLSGIPREVLPAPICVLCQFKSQAGASGEELNPSTKATIDFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWF4</accession>
    <name>A0ABM0JWF4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">8-oxo-dGDP phosphatase NUDT18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103121.1">
        <property type="nucleotide sequence ID" value="XM_005103064.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861748"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769:SF56">
        <property type="entry name" value="8-OXO-DGDP PHOSPHATASE NUDT18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769">
        <property type="entry name" value="MUTT/NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005103121.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="35976" checksum="E126F62901576427" modified="2025-10-08" version="1">MSDIEHQIKAIQNGMPVSVEKRLDIAPEEEMTFIPMTKMNICYICCSILFDDQGRVLMIQEAKKSCHGLWYLPAGRLEPGETLLDGAKREVLEESGLTCDLTALIAVEINGTWQRFTFTGKITGGKLKTTNEKDEESLQAKFFSDEEIKTSRESFRAGDVIKLIDAGRKYYAKESSLRNPDVLPVISPHRLQTHRVVILDRSCPEKATMHVLASEEGGLHIPSSINFLRKRTSIAVSVFALLKDAFVENLTAASIRMCGILGLEHRGTGEQEDGLCITSLVCLDLGDTAAPPTPASSKYQWCQIKDTQLQDYLSKGSKGALVPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWS4</accession>
    <name>A0ABM0JWS4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-amylase</fullName>
            <ecNumber evidence="5">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101860510</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005103373.1">
        <property type="nucleotide sequence ID" value="XM_005103316.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860510"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047281665" description="alpha-amylase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="15">
        <location>
            <begin position="29"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="14">
        <location>
            <begin position="409"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005103373.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="55664" checksum="D2EE4117CF392B45" modified="2025-10-08" version="1">MLVLTACLLLLQLFGSLAYKDPHCTRGRDGVVHLFEWKWNDIAAECKRFLGPYGFCAVQTSPASENRVVTSPSRPWWERYQPISYKIATRSGNEDEFRNMVKTCAESGVRIYVDVVINHMCGGGGSGSGTGGTHFDADTLSFPGVPYGSSDFNDGSNCHSGNGHINNYNNPEEVRNCRLVNLLDLRLSKDYVRGKVAGYLNHLIDLGVAGFRVDAAKHMWPGDIKGILDKVKDIQQGGRPFVYHEVIDMGGEAIKGSEYLDVGRVTNFKFGIEVARLFKHQNALKFLGNWGQAWGMEATGDVVNFVDNHDNQRGHGGGGSVLTHWDPRPYKLATAFMLAHPYGFPRVMSSYEYNRANEWEGPPHNGDMSTKSVTINGMICGNGWACEHRWRQIYNMVAFRNMASGKPVSNWWSGADYQIAFSRGDRAFIAFNLEGYDLDKTLQTGLPGGTYCDVISGNLENGKCTGGSVTVNGDGTARVHVCNSCPDPMIAIHVGAKVGSPERRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JX09</accession>
    <name>A0ABM0JX09_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101862129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101862129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103552.1">
        <property type="nucleotide sequence ID" value="XM_005103495.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862129"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005103552.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="48170" checksum="6575DC2F47308A21" modified="2025-10-08" version="1">MVKQVRSPWRWLIHGRGRLFTSRPSPGPVAISAAACALCVYLLVTSWSTPVRPVMTADWTELPDPPDLTFRDKYFLWDRLHPPAMGDDQWARSDSYLIYRCDPGRMDRCGGLADRLKGMLLAYVMANLTRRAFRVEVMKPSCGFQFYLTPNVYDWSVEDEATLPPPDSGNIVRLVNDHYFRDNIARIHFEEYISPSVREIYFQANLEYMGELRRTRVYHEELSWMEGLSPADIYAALYKRLFRLAPRLQTQLRQLLSKHLNSTRSRLVCTHVRLGRNPSIQGDTEIRNSLRNVKTYLWPFLQSQLLSETDSLFIMTDSAQVDESARQQPFAHRLVAIPGTIAHIDMARGLSFEEMCQAQDRLMLEFHLLMTCDLVVKSASGISEFASFIRGSDRGLYCFHKNGTIFPCQRNRFSNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXZ9</accession>
    <name>A0ABM0JXZ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Copine-3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101854269</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104195.1">
        <property type="nucleotide sequence ID" value="XM_005104138.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104196.1">
        <property type="nucleotide sequence ID" value="XM_005104139.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854269"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF102">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="269"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="403"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005104195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005104196.1"/>
        </source>
    </evidence>
    <sequence length="814" mass="87349" checksum="1DC9952B35156A9D" modified="2025-10-08" version="1">MSQYGGPPSGAPPYPQSQGTPYPAQGQGSAPYPAQGQGSAPYPAQGQGSAPYPAQGQGSAPYPPQGQGSAPYPAQGQGHSPYPSQDAFPQLQTPGQAAAGAAPYPSGPYPNPAASNPSAPPKPSPPPRPTTGPGQGQQGQAPYPGQSPYPAQGQPPHGQTPYPGQAPYPAQGQAPYPAQGQPPQGQAPYPAQGQAPFPGQGNPPHGQSPYPGQGHPQGQAPYPGQGQAPYPGQASHAGQGHAPYPGQGHQPPAHSAYPGQTQGQGANAPRGGAGGRATNPGADQFKSRVEIRIECKNLLNKDVMSKSDPCAAFYMMRAGRWEEMGRTENVINCLNPRFSQSFVVNYFFEEVQKLLIAVYDLDNSTPQLTDDDFLGQIETTLGQVVSNTPLTAPLLLRNGRKAGQGTISISAEEIKEGTESVHLTFRAQKLDNKDFLGKSDPYLEIQRATPDGRWQVVHRTEVIKNNLNPSWRPFQLSLQTLCGGNRQQNIKIDCYDWDSDGSHDYIGGLTTTFDEMSKAAQQETSWPCVNPSKKAKKRNYKNSGIIVLTTCKLFKEHSFLDYITGGMQINFTVGIDFTASNGNPAQTTSLHYINPYQPNEYMGAIKAVGEVCQDYDTDKLFPALGFGAKIPPNWQVSHEFAINFNPQNPYCQGIDGVLQAYYNCIQTVQLYGPTNAAPIIQHVSKFAAMAQREEGSKGAHAYFVLLMLTDGVLSDMSNTRSAIVAASELPMSLIIVGVGNADFSDMEILDGDNGVLRAPGGQPCKRDIVQFVPFREFKNSTPVELARSVLAEVPKQVTGYYKMRGMQPLKNPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZF7</accession>
    <name>A0ABM0JZF7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAS-associated factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101859264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105164.1">
        <property type="nucleotide sequence ID" value="XM_005105107.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859264"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14353">
        <property type="entry name" value="UBA_FAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17129">
        <property type="entry name" value="Ubl1_FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01771">
        <property type="entry name" value="UBX_UBXN3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033043">
        <property type="entry name" value="FAF1-like_UBX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF96">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="597"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105164.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="77103" checksum="B019CBDD7A27C95D" modified="2025-10-08" version="1">MAESRDQTLIDFQAVTGIDDFDLCTNILTQHDWNLERAVNSIMGFGPPEGSGFEADEVGPSPGEHDFEDPSSLRSERLEGFGVHVRPSDHGASDMASGPSYSSSPLNFSSRMINFNVEYRDKNTSVVLPDNETVGRIKEVLESELGIPRDKQELKGLVKRKVDDSTILRDLFLPRDNSLYLLTPEITNPTVNKPPQQEGEGTSQGLEAEREYLLKISFKDGSRYRHFSVKFDCNKTVRDVKQSLTTLTDVPVRHQQWTGWTRPVLDQDKLFACGLNYPTHDLEMTKSEPSSSSTPRAPDLEEMEVDSDDEDYTGLENYSLEEDLFSQEEPRHSRRIEPLMSDGVEDDKLALEQFTTEFTNRYGEIHPQFFIGSLDDAIQESLSVRAADRKLLAVYLHHDSSIFSNVFCSQLLCAEGIVHYLSVHFLTWAWDLTSPDNTARFLQAATRHFGSLAASQMRNYTPDQLPCLLLISRAKATNEVIAAIQGHVTLDEMMTRLIHAVEVYQEQKEADINEEKEREARERIKQEQDEAYQESLAADRKKAEALKEEEVKRQEERAREMEKQKKVEDQKKEDELKKEAISKSVAKSVPDEPVAGSSDKVSNLRFRVMGGEMITRRFYAHNCVGDILNFLTSKGFHTEDYKVLTTFPRRDISTLDKSQSLESCKLYPQETLILEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0L4</accession>
    <name>A0ABM0K0L4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polypyrimidine tract-binding protein 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101858729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105942.1">
        <property type="nucleotide sequence ID" value="XM_005105885.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858729"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12421">
        <property type="entry name" value="RRM1_PTBP1_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12693">
        <property type="entry name" value="RRM2_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12425">
        <property type="entry name" value="RRM4_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006536">
        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="43"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="162"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="339"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="454"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005105942.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="56829" checksum="1E52AA583B397E61" modified="2025-10-08" version="1">MDGDLYNSSGMKRGPDDMQVADGMGDSNDAKKAKFDNGNPPSRVVHIRSLPNDAAETDVVQLGMPFGKMTNVLVLKQKNQAFLEFEEESCAVNMVTYFKTNPAQVRLKSCYVQYSNHKELKTDAANVQNTSAQAALQAAQGLLGSGTAPGGGAAGGEQTTILRVIVDNVLYPVTLEVLHQLFSRFGKIMKIITFTKNNTFQALIQFSDPISAATAKDSLDSQNIYNGCNTLKIDYSRLTNLNVKYNNDKSRDFTRPDLPAGEGMLDGGMGMGGGMGGMGGGMGGGMGGGMGGGMGGGMGGAGVLGSGANAMGLGGGFNFGNGMGNRMGNMGVNSNQGSPCILVSNLDEEKVTPEALFILFGVYGNVHRVKILFNKKDNALVQMADPTQAQQAITYLDKAKVWGRTLRVAPSKHQLIQMPKEGQSDAGLTKDFVTSPHHRFKRMGSKNYIFPPTGVLHLYNVNTLEEDDIRNLFSQYGSIKAFKFFNNDRKMALIEMSTIEEATLALIGLHNYQVGDSLHLRVSFSKSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2B2</accession>
    <name>A0ABM0K2B2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101858212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107064.1">
        <property type="nucleotide sequence ID" value="XM_005107007.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858212"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005107064.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39853" checksum="D5A952A541C0132F" modified="2025-10-08" version="1">MSWNPEQRFYSQPLPAVGEFVKVRVTRVTSLGVYTELLEYGGQEGMIVSSELAKTFFRSVHQLVRTGKALCCKVIRVNEKKKYIDLSKKRVTPEDDEACHARYTRGKLVQSLVLRTCQRLDIQDAGSVLGMFEKTAWLLDTMAGRETAALDVFKDAVRTPSVLDQCPVSPEEREALLETIRSRLKEPQLHLCAVIAVTCWGPEGVDAVKDALKHGGQEGADDTGAKVKILYKEAPYYNIFLETVARKRADGVATIEAAIAAVRNRILQYDGGGFRLVTKPTELRKTRHCAELPGEEEVTYDEGFSSDDSEDDETSCSVEEVRGEESDELARKAEQSLADTDVLRLLISGEDSGIVQDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2E6</accession>
    <name>A0ABM0K2E6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101857139</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107139.1">
        <property type="nucleotide sequence ID" value="XM_005107082.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857139"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 14" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS4 N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="10">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 central region" evidence="9">
        <location>
            <begin position="96"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="12">
        <location>
            <begin position="213"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005107139.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29794" checksum="3FF5F7CA4AAA7308" modified="2025-10-08" version="1">MGYRGRRKSLKRLTAPKSWMLDKTGGTFAPKSSPGPHKARESFPMTLFLRNRLRYALSYQEVKKIVKQRLIKVDGKIRTDNTFPTGFMDVVTIDRTNENFRILYDVKGRFVVHRIKPEEAKYKLCRVRKVATGPKNVPYIVTHDGRTIRYPDPLVKVNDSVQVDIASGKMKEYIKFDTGNLVMITGGHNLGRVGTITHRERHPGSFDIVHIKDALGHTFATRLSYVFVIGKSNKAMISLPRGKGVKLSIAEERDRRIAAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2L1</accession>
    <name>A0ABM0K2L1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855444</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107299.1">
        <property type="nucleotide sequence ID" value="XM_005107242.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855444"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107299.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48528" checksum="6B89E47545D8172E" modified="2025-10-08" version="1">MSQQTRERISTLTLLENTLDQQLESLEHELSLNERKYVILQALGGASDSLDQLDSRIQRGRGLIKSLQPLLQQLFEERQMYIHLARLKIGSQDLDQREGDSVAGEYSCPQTEDGYCPCQHTEDESGMFAERSNERSKKSAIKRLEYVCTNRLDHHRPSHDVKQDNSQEFSGQSGSTEGDSLPCRTREPALSDRESNTMTFFGGCGGGPNLSSPSYNDTRQAVPHHLHSDAAFLTATSPDFMSEAQGGFTCYGLSEAHMVPDHNISETQLTFTCGTSGPLDHSSHETQMMCACNTSEAGMDLDHDTPEGHKIEMRSIPELAISSDRTTSAAQRERVPSSVSTQRVTREVQGLPQHRFHTHQELCPPSPTSHTTRVPPPSGASHIARHNGQSESSLSWHVQEDEMEEEEMLQHSVYHCKALKVSSLLEEEFLMRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4T5</accession>
    <name>A0ABM0K4T5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cystinosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101856379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108750.2">
        <property type="nucleotide sequence ID" value="XM_005108693.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856379"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108750.2"/>
        </source>
    </evidence>
    <sequence length="442" mass="49730" checksum="499A4A0A8D49E70D" modified="2025-10-08" version="1">MEANEGDPGQEPNEPVMFCVNRPTDADCVLSTVQLQALIGTDLAGKMNFLSSFFISLIYWTGLSIHLVSGQNGTIVAHFSTDSIDTEIGDTSNVTLSISSFLQENTTLLFTYEDKYVDSHDYIVPIPNITVDASNNRTSWVVQIIGNNGGHVIVGVNSSSVEFEDIKKAYIRVDVVHSSALVIINAVIGWVYFVAWSVSFYPQVYTNWKRKSVIGLNFDFLCYNITGFLAYGFFNVGMYWVPSVQAEYFSDHPRGINPVQLNDVIFTLHAVFVTILTIVQCFLYERGDQRVSKICIGLLVGAWLFAAIALIVTLTHTITWLTYLYYFSYIKLGVTLIKYMPQALMNFRRKSTVGWSIGNVLLDFTGGSLSLLQMFLLSYNSDDWGSIFGDPTKFGLGFFSILFDVLFMVQHYGLYRNREPYQQIKDSEVSVSKDTPSSQYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K511</accession>
    <name>A0ABM0K511_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U5 small nuclear ribonucleoprotein 40 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101856927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108922.1">
        <property type="nucleotide sequence ID" value="XM_005108865.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856927"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005108922.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38186" checksum="3097DE4C2130CCB2" modified="2025-10-08" version="1">MDLKRKAMDGALVPMKKPRHELVAVGSQGAGALVQSGPPRTSNLLAPIMLLTGHEGDIFCSKFSPDGQLLASGGFDRLIYFWTVYGECENFAMLKGHTGAVMELQYSTDGSMLFSASIDKTVAVWDIEVGERLRKLKGHQTFVNTVSPARRGPQLICSGSDDGTVKTWDARKKGTINTFQCTYQVTAVTFNDTAEQIISGGIDNELKVWDLRKNAVLYKMRGHSDTVTGLELSPEGSYLLSNAMDNTLRIWDVRPFAPQERCVKIMSGHQHTFEKNLLRCSWSPDGSRVAGGSGDRFVYVWDTTSRRVVYKLPGHAGSVNEIDFHPLEPIISSCSSDKKIFLGELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K518</accession>
    <name>A0ABM0K518_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859973</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108935.1">
        <property type="nucleotide sequence ID" value="XM_005108878.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859973"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047240494" evidence="1">
        <location>
            <begin position="28"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108935.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17102" checksum="0C1C54EB500AE866" modified="2025-10-08" version="1">MGRHNISFALLKAVLLAFSSQDYFAECATIVTSASSSFFLGHPATLTCADNASATPATPTNHEELLVAWFKNGVRMKNTTRKLKFKPLAKNDLAVYSCTFESKLLPGVNSEMSTDPPPLLRALNLMDKERNKEHGNRVIPHPKSALGVCKYSRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6B5</accession>
    <name>A0ABM0K6B5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromatin assembly factor 1 subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101851079</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109746.1">
        <property type="nucleotide sequence ID" value="XM_005109689.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851079"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005109746.1"/>
        </source>
    </evidence>
    <sequence length="571" mass="62446" checksum="03C900CA1CFA1913" modified="2025-10-08" version="1">MKVITPEISWHEREPVYSIDFQPGDRAIRRIASGGVDKIVRIWQFRLDEEGKGCVEFLANLRRHTATINVVRFSKNGELLATAGDDTAIILWKLSDVPPPANNIFADEDGDEDKESWVCHKSLRGHLGDVADLCWSKDNRYLVSGSVDNSAIVWDIVKDQKVAIFNEHKSYVQGVALDPLGDLVATLSSDRSLRVFNLNSKNCVNNVSKMAPLPSSQANAKSGDSQNTAPDPKPKPFRIFHDDSLRSFFRRLEFSPDGQLLMTPAGCVELGDGKLASTSFVFSRGAFAKPAMYLPSGDKATTVVRVNPQLFHLRPAQSDCPAGDTEGSDSKQEKEWDKNKSLFCLPYRVVFAVASEDTVIIYDTQQTMPVGLLKNIHYHQISDLSWSGDGKVLVISSTDGFCTIATFEDGELGEVYTKANTDEGVSVPSTVPKGVSSKKKVVTGEDKPSETSLPFSRYTSPKEKKTEEKSIQKQSSESSSSNGNSKNETSETSSSQVADSNKSQTKSANGEVKGDTVKPDTAKTEVSEKVESLTIKDSSNKMSSESKQGGGKNPEAPKKKRAVLTTISLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6K0</accession>
    <name>A0ABM0K6K0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ectonucleotide pyrophosphatase/phosphodiesterase family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109937.1">
        <property type="nucleotide sequence ID" value="XM_005109880.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855906"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005109937.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="57714" checksum="0F888FB4DBB29B24" modified="2025-10-08" version="1">MRKHGFQILLGWLFLATICLLLYFPFSLSHTEKVPSLLIVSFDGFRWDYLTHTPTPHFQDIILKGVHAKKGLHNVFTTSTLTNHWSIVTGLYAESHGIIDNEFFDPVINKTYIPLYKNKNAVNDNRFYDTGAEPIWVTNHLQNHNGRSGSVMWWGAENVIKGVRPTYHMPYDLNVDEKSKIDTIIQWFTSEYPINLGLLYFSEPDHSAHKYGPDSWNVTQKIAEADELTGYLIDQLNKRDLLDDINIIITSDHGFAAVSRDRLIFLDEYVDPKWYHMVHYSPVATIIPHEGKEEMIYQQLLHASKDNHFQVYKKADIPVRLHYKNNRRVTPIVAVADITYSFISNMSADKFVLAGSHGYDNKYTDMRPFFMARGPSFQENFAVDSFSSLDLYPLMCHLLHLEPAPNNGSLAIVKQLLVEPSENSGWTFSTYIVCLILISCVGGLFSVGACRQHRYLRRRLNQLRSVSALAPDKVNILKPEHSTHVPLLFGEEDDDDGELEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6X3</accession>
    <name>A0ABM0K6X3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sperm-associated antigen 7 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110156.1">
        <property type="nucleotide sequence ID" value="XM_005110099.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847380"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017330">
        <property type="entry name" value="SPAG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13498">
        <property type="entry name" value="SPERM ASSOCIATED ANTIGEN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13498:SF3">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037943">
        <property type="entry name" value="Sperm-assoc_antigen_PAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="2">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110156.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29163" checksum="76827666FB1F235E" modified="2025-10-08" version="1">MADLLGSILGSMEKPPTMGSDERKKAKAQKAMMEKQQEAEKKKIDAFRTRIQKKIHEFIKDGTLEKLKLEPMEKGMRAIVHEVSEVAGLTSFSFGHEEEDRYVLMWKKEFAPSDEELLAYRRGEEWDPEKAKEMEKLKEIQSKEEEESRKQSLKETPASNYRDKYKHLIGDEAAKDAAREMVSNSSYGFVPATNKRDLRTIEQVLADTRAKKKQKLDPSAESSGSPSASGDQGEGVGAETSEGAGEGEGVLAEAQGETEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K942</accession>
    <name>A0ABM0K942_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 7 homolog A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
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            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
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        <property type="nucleotide sequence ID" value="XM_005111762.3"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12951">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RRP7"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="53"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111819.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31770" checksum="A956F83A0066BB9E" modified="2025-10-08" version="1">MAPNKLKKDAPLNIQGYTVLQVKPTVRSNVCHCMYLREHSAAVPRAEWPQGRTLIVHNIPPYCNEENVRLLFKECGDIIRVYLQSKPSSKPIVQSQFLPTSSEKGVQIAYVVFRKPGGVKNACNMVYDKERLLSDANTPIIAGLRAYIKEYEDSVTDVDALEKSAEEFMAQYYKKKDEEIKREKEMEGVPDEDGFIKVTRHGKNKGLRRTEETEKRGHEHIRSRKKKNELKDFYVFQYRETKRKHIAELQAKFEDDKKKVKEMKIARKFRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW53</accession>
    <name>A0ABM0ZW53_APLCA</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101864131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101864131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935773.1">
        <property type="nucleotide sequence ID" value="XM_013080319.2"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44733">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44733:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="153"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012935773.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="50651" checksum="969A0914AA904F3E" modified="2025-10-08" version="1">MHTGTEMDCVDKNTLPPTTSNGVSNPAYGSVVSTPQPGINQSHWGVNQPGAPVDQSAVSSDQSFQTSSSSQRTVRPAQSFSKKTMFEAYLLWLCVGLLGGHHFYLRRYSFGVVYFCTFGLLGIGWLVDLVRMYWLVKQANEKAENPWLRQQFSMVDAYVLWFPFGFFGYHLFYLQRPAQGILYITTGGFFGVGWLVDLFRIPYMVKSMNALPGPYEKDRHLVESGCLTFYLTGIAGCHHFYLKRPVWGILYTFTLGLAGFGWLYDWFRFVILTRRANAIKNGTLSSSKKFKDDIFILWFPLGILGFHHFYVHRYGWGFLYICTFGLFFLGWFADIFRIWSFVDEFNRQEEERERETRQPIPTCAQQTNVPAHPLSREVPEVGGATATSHLGPSPGLPATAPYHWLPGSGGERTDPGIVEQGLGGGFAEGEMPGLPTYEEAMTGSKQLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXC9</accession>
    <name>A0ABM0ZXC9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011419</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936447.1">
        <property type="nucleotide sequence ID" value="XM_013080993.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011419"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012936447.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18488" checksum="0896316FAB32EB06" modified="2025-10-08" version="1">MPTNYPKLLLKSKDCPLPTANHNQLRMPTNYPKLLLKSKDCPLLTPNHNQLRMPTNYPKLLLKSKDCPLLTPNHNQLRMPTNYPKLLLKSKDCPLLTPNHNQLRMPTNYPKLLLKSKDCPLLTPNHNQLRMPTNYPKLLLKSKDCPLPTPNHNQLPPAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXP9</accession>
    <name>A0ABM0ZXP9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RB1-inducible coiled-coil protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101858260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936638.1">
        <property type="nucleotide sequence ID" value="XM_013081184.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858260"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17060">
        <property type="entry name" value="Ubl_RB1CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="7">
        <location>
            <begin position="129"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="8">
        <location>
            <begin position="1399"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="725"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1259"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="800"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1044"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1128"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1282"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1262"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012936638.1"/>
        </source>
    </evidence>
    <sequence length="1544" mass="173398" checksum="ABDCF0B8A3E7648C" modified="2025-10-08" version="1">MLYVFQMDVGQMLTFDISLLMDTVARLQQEIAHVTGISVDQQILLLSGGQSLHPDQKVISYGAGADTNPVFLFSKLAITSQEPPLIKSFGVSKEVLHVLKDRVADAVKLPVSFDTVTTRTKLAIQVRDNAGKILTFCNNEFKEQHLQHQGWSAVVANLEEIAQALQKTRSKFSKMFATFLPLREKHFSLLSNFQEVLELLSRIPLLKPLREEEEEVIVQVGRKSVADSDVLSFISPSPAPVNLLEWITTQSKGQSLEGLQLKCYNDLVFFNEEMFDQYERGVHELLDLVSADTQMKALVGIERRLSELEKRLNEAKRIAKAQNDMAQAFMSQQSRLSSTPDSSVLPDLCTSHKQQLRQMLDGHQRLEALQGNFCRSKQEMSTNIHHRLGWVVDIETKISKLDSDLIFHMKTLKLLEVNLELLSQVKAAPQVYAQMVMEAARRKVFSQQFELWADSLVGDSKQLYEAEVELRKHFTNKLGQHFFLHTLFKGFGDMPPNFATKAPQQFDSSLPNITTEDISLLKSSVPELEGSLCTPIVVQSFPQNQASFRRLGGSTSPHSVLPNSQSSQTEWSHQLGDIPSVVTATEAPPTTFSLPELQESRATEYLPAVSSLTDTMREAISSETVTAVESTAGGQTEAMGAGAGGERPASQGSQSGKSKTKANSVHTTESTSPLSSTEFATADFYIEDAMPSPMRSTSDSETISSLQAELLDKVNLIRDLEEKLRKRDNRQTSDGCGTESGPVNVTKQSSSATLVGVVDVSEQVSTSNSSEAENMEIVALEQVSEEAEGKRCCCDQAQAKEELDRRIASCQQTIEELSHVLEDTEKDKLVCEEKYNRCIEERNRTVTELEVRLKATEAELVDVKTKVESCNSDLHKLKLSLSESRAVNEELQKEVNKGEESLVRVRGRLLEFRTIAREQLSSFRNVLKELKSSVSDNKRDVDTSVVSLLNTVEEKVSCFNNSVLADANSEFVKEKEVLNTSILALKAELSEARAANNEKVLHLNRHNEELSSRLLENQSHFTKNFSEQQAEFDSAVKELKTKHSLELELEVEGCKTEMRKLLDEAEQQVATRDKLLEELRCEVELAKKTAGEERVRLETVHMDKLCEMEKRHQAKLESNTFELSEKYRTDFEATFEKGNEQIAQLKNQLENLEKSLVAEKEAALTQLVDEHGAALRELEQKLEEQREDMAQCLEQKQLDHAHKLTELKIQFDLERESLLAELRKVKDHVMTSSETQTDLLADVISLTSSASYGSEEMIANRHPTTQTEDSSTATDNTAEASRAKLQQTIDDLNTQLTSAQERISGLQTEVDTVRQEKDELMTQQKQLEEAAPRSPDQLSQSRMALLSSEFSRYQEMMESTGGDNSTSFILMDKERISSPTSPTDNEEVKMRDVKIAELEKKVMEISMTASEKQSANDKVSIKGCERGDLVLLCLDERHDQYVVFTVGANLHFLHSDSLEPLGLKRSVDLSCRKTWILAEVVDKEYCLAKKPQNRFRVPQGTCFYRVKCKPWRSEAECGKELVRHVKPPKGERGEGARPKKSDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXZ7</accession>
    <name>A0ABM0ZXZ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Matrix metalloproteinase-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101856506</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936807.1">
        <property type="nucleotide sequence ID" value="XM_013081353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856506"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="14">
        <location>
            <begin position="34"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="11">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="11">
        <location>
            <begin position="269"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="11">
        <location>
            <begin position="313"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="11">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="419"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012936807.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="58055" checksum="1B1716973A1353BD" modified="2025-10-08" version="1">MEATPLWEQGQRRSRAGGQAEAIRAAGVHPLFDAGSKWAKRDLTFKISEYPRGMSRDRVEKEVHNALKVWGDVTPLNFILRPYDDRVDIDVRFARRNHGDGNPFDGRGQTLAHAFFPQYGGDAHFDDDENWTINLSSGINMFQVAAHEFGHSLGLSHSDVGTALMAPFYRGYQRHFKLDQDDVNAIQELYGSPGKRDRGYPRKPAPPPPTRGPVLSVPKICLDSKVDAVTMSSDGYTYIFKGKDYYKLSNYGIASGYPRDIAADWRGVTGPVDSALHWDNGYTYIFKGDYYWKFYNFNLIYVRSIEEGFKGIPSNVDAAFVWGGNGKTYFVKGNQYWRYTVNHVDPGYPKPMSVWTGLPERVDAALKWKNGRTYFFSGDMYYRYNDVDFDIDTSYPRTISNWWLGCPDREQINQISGQVADMSQSKDTEENAVNESPETDKGSAPLQGLEVDSKSDQFLPIDTQTGSKSMGLSQGDGGNSAASLGRRDLALTVFMSCVLSWLYISCAIPRYIMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYC8</accession>
    <name>A0ABM0ZYC8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Testicular haploid expressed gene protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937054.1">
        <property type="nucleotide sequence ID" value="XM_013081600.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854321"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042401">
        <property type="entry name" value="SPMAP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006623">
        <property type="entry name" value="THEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15901">
        <property type="entry name" value="TESTICULAR HAPLOID EXPRESSED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15901:SF16">
        <property type="entry name" value="TESTICULAR HAPLOID EXPRESSED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14912">
        <property type="entry name" value="THEG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00705">
        <property type="entry name" value="THEG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045074438" evidence="2">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937054.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33716" checksum="22B78A9E8E4D8800" modified="2025-10-08" version="1">MVLPVSFSLTLPAFLHEVVAGYLCDSKLNVTAFCFRCFITFAEILRIDTLARPKRLPAEYRDDRRSVYWVEREPLRCGPDGHTVVAATPRVIELSRHKTVVGAWRPHRPTPIWPVASGAMSAQPSSRITQLSQHRNPHNSYLFDRDPMWDVTDEAAQARASERLEQLATPKTREERFSNFDPFWGYTYPVSENAQRSRCTERLESLAQHKGYHKEFKDERPIQWEVSQEAIEAIASLRLQQLARPRSRTMIKDDYDPYKVSPSAKKTRATPRLEELCLPIPRKVRQKKALGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYL3</accession>
    <name>A0ABM0ZYL3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tensin-1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937213.1">
        <property type="nucleotide sequence ID" value="XM_013081759.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860166"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01213">
        <property type="entry name" value="PTB_tensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09927">
        <property type="entry name" value="SH2_Tensin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058599">
        <property type="entry name" value="PHAT_Smg/ZCCHC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035012">
        <property type="entry name" value="Tensin-like_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033929">
        <property type="entry name" value="Tensin_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF10">
        <property type="entry name" value="BLISTERY, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26034">
        <property type="entry name" value="PHAT_SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="8">
        <location>
            <begin position="1097"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="524"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="980"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="759"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="980"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012937213.1"/>
        </source>
    </evidence>
    <sequence length="1378" mass="151394" checksum="B16DD737D17A22DE" modified="2025-10-08" version="1">MKSNNYREQVALVISWFKDWSECEQTVALYSLLKKSSPIQAKFLDQVLQQSLADCTDVKQWEAKANDEVYVRSLYSEEKEIVIHQLLQLLPLLQVGKHSVKAAYLQLIPELLSHTIHNGVNIEESRQLLSYSLIHPAITAEERGTFQTWLGCLDERFTYSVPLSNGLSSGGSTTNSSTGGSSSNNSLSVGLGPSHSPSPGSSSQHSLAHLSPDLSVSQEYINTISTNQGLVQQQQQQQQYNSSSSQQSTLSRRTAQTLEERTQLDELLSDLLSEQAYVSPTQRSPGSFQTAVQSQQGPSSPPGSGGPSSMSGAKTVTTTTRTFTSYSSTDAHRNPDKVLIQRAEVSYKVPGQGEKVDHYTIAADPSQTLDTGRPSQQPPYHPKGVPSNAFSYTTLVDGHSELQSSQQRSEVMEHENMRSASSAPVQSPPPSRLPYRPDYNDGSRYDTTSSSFSYSSLDGESNSWLQQQQQKLKNFKEGRDSTGRTEQEKRLVNELRFAQNKYYTRRTQNEEDERAVMDSYNRQNLLQNGPTSPNRAVQSYAPPPPQRSHSTSAVDGPWTPQDQQQYNTYSSSSYTESRSYGDKRSNKPPPSPTMQRSLPPASVQPPAPVPARSSSKEYMRTRSNSSSSSWQQQQQQQQQQQQQQVFAQRPLQRQTSDTLYDRNREVEHVQPRSYGSVHSTPPHSPRAISPAGPTSTTTYTTYRTLDRPPQEQMQQVQRAPPQQQAPPPQPPPPPPPTQVNHHYITEVFVHRTDLNKDKTDSTSTRLDELEKNLEAASQSILATQQAPPPQPRQQVVEETVQQSRSESRQFQTFAETKPEPRVKEIEEDRIMLRPIGPGMQTLEPESAHTGTLGRPTTPGFPTAPATPPFPVSPRTPYQNPAATPATPSSVFSSSQGSVFHYAAGGGGGAGGGGGGGAPLCPPQRQFSRASVGQRGWDYDPTYATIPEDMVLTSVVAPQMINQVGTLHTLPLPQQQQQQQTIQYQQYSQSQQYQTHSSHHDGPGQGTLHIDTSPKMLVAPRSPSSPPSPGNLNTLRQQLSSAHSMSGSVVSPGPHSMTGQSSPSVYFGLSRRGSLSSLADSDMVHTTPKFVKDTSKYWYKAKISRDDAIQMLRDKPPGTFVIRDSNSFPGAFGLALKVATIPANVQAKPSGDPQADLVRHFLIEPTPKGVRLRGCSNEPVFGSLAALVYQHSMTPLALPCKLALPEGDVVDGLMTPESPMSAVELNSATTLLTQGAACNVIFINSVDMESLTGPQAVAKAVKMTFDNLAQGRTTVVHFKVSNQGITLTDNNRKLFFRRHYPVSAVTYCGMDPQDRRWKREIDAPGVQGDARLFGFVARKQGSANENSCHIFAELDPEQPAFAIVNFVTKVMIGQSKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYQ4</accession>
    <name>A0ABM0ZYQ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caldesmon-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937290.2">
        <property type="nucleotide sequence ID" value="XM_013081836.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856546"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937290.2"/>
        </source>
    </evidence>
    <sequence length="1018" mass="115384" checksum="DB60EB72AE76E6FD" modified="2025-10-08" version="1">MNININLRQKRRSFSQWWRLASKSTRIERTREEREEQKMEGYIIPKKKTSNNDPYGLYSTLSKEEARREREKIARLSREAWERAQKKDYADVENKTSVKRKSTHESSSSSKRFRSSHSQSFVNHDNRWKHSLPISATETYLESAKPPKKPIVRHANKKGVPPPMDFKTVLAMAEETQRERVRPTAAISRNKIGKTQRPNAEKERKMQRSKVVEEGKRRKPKAEEEGKRQRSKAGEEGKRQRSKAEEEGKRRRPKAEEEGKRHSSKAEEEGKRHSSKTEEEEKRQRRKAEEEEKKEKTKSVECRRLLKFCGDKPLRQRDGSDDGAAAPSGTSQTRTSTPSSCSSRDKSQSSTESQYVTGVGTESPNNNSCSKRSNGGHSSSRKIRNNRNSNIKKNCSINNDNDNNNIGSCNNDKSKNNSNNNKLSASKRKALSVCGRSGVDEVKEATTPSSPQNSVNPLDETTSHVHEKPHTQLQTAKSTRIERTREEREEQKMEGYRIPKKKTSNNDPYGLYSTLSKEEARREREKIARLSREAWERAQKKDYADVENKTSVKRKSTHESRSSSSKRFRSSHSQSFVNHDNRWKHSLSPISATETYLEPAKPPKKPIVRHANKNGVPPPMDFKTVLAMAEETQRERVRPTAAISRNKIGKTQRPNAEKERKMQRSKVVEEGKRRKPKAEEEGKRQRSKAEEEGKRRRPKAEEEGKRHSSKAEEEGKRHSSKAEEEENRQEGKRQRRKAGEEEKRQRRKAEEEEKKEKTKSVECRRLLKSGGDKPLRQRDGSDDGAAAPSGTSQTRTSTPSSCSSRDKSQSSTGSQSVTGVGAESPNNNSCSKRSNGGHSSSRKIRNNRNSNIKKNRSINNDNNNNNNNNNNIGSCNNDKSKNNSNNNKLGASKRKALSVCGRSGVDEVKEATTPSSPQNSVNPLDETTSHVQEKPHTHLQTDPGEQIEVPGDHSDAVQDLNIDVPIAGESVEEFVYGDLKDWISQELRKMCCFDGSGSKGDSTEDDVSSMETDPSNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ32</accession>
    <name>A0ABM0ZZ32_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amyloid-beta A4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101847036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937483.1">
        <property type="nucleotide sequence ID" value="XM_013082029.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847036"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045782182" evidence="4">
        <location>
            <begin position="25"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="62"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="179"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
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            <begin position="130"/>
            <end position="151"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="170"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012937483.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30957" checksum="8E09D003F5A25630" modified="2025-10-08" version="1">MGGPMSVLCAFLCVYLFAHLPCGARSIPEKDMPLDSGDVIMREDAEEVFYNVNIEKYDDLGIRCPEPEPPENGAIKGEGTRVGSVVYVVCKEGFVLHGPTVMACVPFGEGAQWDPSVSRQCVEGRHEFEETNEVSAEDSESEEIPPEPESLEEVRGRETEEEDGVGEEEDARPPPYLSPRLHKSRLAFKQHNNLPEHVPEEERADLESNMLSEELSQTPRGCFLTPDPGPCRALFRRYFFDKTTMECHPFIYGGCQGNENRFATMEECNSECLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZF9</accession>
    <name>A0ABM0ZZF9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Synaptophysin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101855641</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptophysin/synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937697.1">
        <property type="nucleotide sequence ID" value="XM_013082243.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855641"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001285">
        <property type="entry name" value="Synaptophysin/porin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306:SF17">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306">
        <property type="entry name" value="SYNAPTOPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00220">
        <property type="entry name" value="SYNAPTOPHYSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="10">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012937697.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="28818" checksum="A703F0669AAC0D2A" modified="2025-10-08" version="1">MEGGGSGPIQASFSISPLKEPIGFIKVIEFVLSIFAFATTTSHETSTTFNINCTAVPHHEVAGEKSVTFTYSYSYDLEDVCFRTPICNNTKTGEMCLLSGSESSAQFYVFVGVIVFLYCLAALVLYIFFDELYRRNTRIVIVDFVVSVVLTLLWIIGSSAWASGVSDVKMYTDPDEGSIFDNLAECKNANANCRTVNDGNFASLNVSIIFGFLNFVVWVGNLWFLYKETPWFKVQARPPSTPAPDVSVIPNSIPAPGAEGGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZR3</accession>
    <name>A0ABM0ZZR3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deleted in malignant brain tumors 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101855611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937884.1">
        <property type="nucleotide sequence ID" value="XM_013082430.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855611"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
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        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="3392"/>
            <end position="3415"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
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        <location>
            <begin position="2249"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2366"/>
            <end position="2376"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2474"/>
            <end position="2484"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2586"/>
            <end position="2596"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2698"/>
            <end position="2708"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2808"/>
            <end position="2818"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2880"/>
            <end position="2944"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2926"/>
            <end position="2936"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="3037"/>
            <end position="3047"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="3144"/>
            <end position="3154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="3254"/>
            <end position="3264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012937884.1"/>
        </source>
    </evidence>
    <sequence length="3533" mass="385389" checksum="4B9369181BD708DC" modified="2025-10-08" version="1">MYFILQGVAGAYLGHRDTEGFYRKMSCEGSEKSLGDCSSSTTSLCRPDSSVGLVCFNNVNDVLEMRLVEGPALRPNTHSGRLEVRLSPLMPWGSVCDDSFQGQSATAACRQMGYKIGESLRHSFWESLFEEEGVFGSSERTWLDEVSCEPGQEFLDCDHDIWGYHDCDPVEDVGVSCSNFSVRLLSAVPNDYHIGSVEVYLERENGWFEVCDVDWDDNDARVACRELGFADGRALCCNSLGSVSYGSLTAMGSMTNFTCTGKEESLTECGMIQTGLCNFNEAIINLAAVICYDKPFEEIDTTLKTRVVDGSEHAGILEVQYMGVWGRVCMDDSIFESEFTDNEASVACRMMGKGYSGGKRINNEKTDDIYHAWLRGLTCLGNESSIEDCDHPAWGSPALDNCEGPVRVVCYKSALELVIQEPAMGVDVRGVLTVKYDGTTSVVCGDDWGDQEANAACRTIGYNGGRAWVPHTYDHSLVPILSGVKCRKSETNFFQCDNHGWNIPSEECITNPKPAGIACFEETKLDPGYKASGVLQLFDNKTSTWSTICRNGFDEIDAMVACKKYGFSQGTVLPAGAFGIVGSDVGHLRTSINCTGSETHITDCPYDEDIVDCNLYGDYVSVSCFNEVRTGTFAVENGFSDDTQAVGVLKIFQNNTWGFACGQTFNELDALVFCKELGIALGHSYSGGVSFTQQKDVKGPYFVTFPNCNGSEERYADCSSSQYLCTDAAAASVLCYTSGGPSLEITGHGGPKQGARLQLNINNVPGAICANKWDDQDASVACRQLSDVYKRGVATSYPRSSLPIYLSGFECNGEEDHLFTCDNDGWKPNPSVSNCDENSMEAGVVCFGRVFFTEIKQTPDSLSGLLNVKMEDDYDRPVCFESTFTHREAKAVCDELGYSQAAILTPKSLDEDLKYSYYTLTKVQCLEENVHLIDCGMRVGQCPTQNQVRLLCYEYKIDLLSEWTVEKNDHGVVSKAFLDNQYIAAICPQDWDDADADTFCAERGHTGGKALGSTPLDQMETRELVWFGSSVCSDSPNGRKQCEVQQNVSFGCFGQNNRAGVLCYTGEEITMRLVDNGKVSKFAGRVEINYQNVWGTICHKDPNKRLVARTVCQQLGMIDGTIIMASPKRYGMTDSPIYLKNVDCSASEDSILLCSHDGWGMDEGCTHENDLEVLCYSNVRIFPDAESPHGAVSIYSGGSYVLLCSEGFTDAEADVICRSLFYNSGKAICCSALPIPYLRIGASNAHCSGTESSLLDCNLNMDRESFNCPSAKYASVACSNELVNEYLPFLERGDRGRVHIRYYGLTGSVCAKGFTHNDAKVLCRELGFSTGLAFTTTNTDDLQFPWLVTPQCLGVESSLSTCPKFSLGMAPACDEIATVQCLPATDPGKIEVRIADIPGAVYGIPKVKIGGTWGTICDDLTLSDEEAVVLCKELGGSGGTFLHISDPSVLSRPSPILTGLKCQGDESSISQCQMYAFGFGDMAESCAIRFDHAVLQCFNSVELVQGPVQARSGGLVLLHEKETDEWHPVCDGTISDKEASVICKNFGYQYGKQQCCNAFGELEETANTFVTKLSCPSMDSLISNCSVSRGKACPTEGSIASVHCRSSPFPVENLQIVHLPDFVGSPTVQRYGIEGRVCAEGFQEKEANVICKERGYAKGHMLMNSKVGTGSTFMVGSLNCSGTETRISDCDYAVWNSDGSCPNREEPNVLCTRTVLNSLKYQVNTDSGRAEVVVDGTTYVLGFHSFSNKEAAVFCKSLGKGYLSGNTLIRRVPGTVQERILMDFISCSGTESSILECTGSLLPEAPSEVTADSVVYVECSLGAPVNLNLMLLLEWLTFFFRSAVVIVPFNTCVSSAVELVQGPVQARSGGLVLLHEKETDEWHPVCDGTISDKEASVICKNFGYQYGKQQCCNAFGELEETANTFVTKLSCPSMDSLISNCSVSRGKACPTEGSIASVHCRSSPFPVENLQIVHLPDFVGSPTVQRYGIEGRVCAEGFQEKEANVICKERGYAKGHMLMNSKVGTGSTFMVGSLNCSGTETRISDCDYAVWNSDGSCPNREEPNVLCTRTVLNSLKYQVNTDSGRAEVVVDGTTYVLGFHSFSNKEAAVFCKSLGKGYLSGNTLIRRVPGTVQERILMDFISCSGTESSILECTGSLLPEAPSEVTADSVVYVECSLGVQLDSGPTPSSGILSIFNTQTDRYGVVCDKDFGQKEADVACKTLGYEKGILHCCQAYGYNFEEPLFKDFQCNGAEQSILECDHNPAATRSPFFCNRQDYVAITCYKGERPDDFTVSMDATNQNIQSGLVRVTYLGIEGTICSDGWDDADANVLCRHLGFDKGTAYNHYKPGFTIDASEGPFWLSEISCFGNETDLTSCPHSGLGSVTHCRNDHFAGAFCSDDSIVTYRLAGSDNVQSGRVEVYINNQWGTVCDFNWDSKDAAVMCRMLGYATGDEISDTSLDNVGTGPIWELGARCSGTESTINECPHQGWSENRRQSCEAHSDDAAVFCYSSVKLERASGMETNHGPVNYYYSNKWYRVCSDGFTDLSARLVCQEMGFYDGRSLCCSAYSGETVSGRKILPNITFECVGDETFITQCRQESECISGYYASVVCLGKDDNFDENEYQVTMSPGEEMKGALEVSHLGIKGRICSAGWTDKEADVFCKSRSFKGGSAYHRSYFDEYISSKSIGPLLMSNVICNGTERDLTECSFNDRSNLGNCSDSHTAAVYCYKEEGIKYRLVFNDTFDQSNFGRVEMSVDGKWGTVCDKMWNDKAARVVCRGKKFRDGAAQNNAPYGGGEGPIWLHSIQCTGEEAYLHQCAHDGFYENPNVFGNSFWFINPCSLHSNDASVFCFNDVKLDQPLEQSSGGLLYNMDDKWKHICSDESFSRKEAMVACKSLLQDYVDGVPIQKGVFGEMEEPLAPVSFSCSGEESTLSECSHNTASQCASETYMSVACFKETLTDSDFEFNLTLSSDSIRTGDNHGILEVRDKGAWGRICMHEFTDAEASVACKSLNFKGGHKYLHLFRNRLPILWSGVKCSGSETSLDQCMHSSIDKEHCHYNANDAGVVCYKSEGVKYRLTGGKDQNSGRVEIGVDGIYGSICAINWQQGNSKVLCRSMGYTDGIPTYDENPDLDYLAPVMSFFLCEGTEDSLLSCINSGFDDGAHVFVCGGSAYASCFKEEVQITEVRLQGGNSTAGRLEVYVTPLNAWGTVCDDSWDDIDAGVACRQMGFDDGIVMESDYETGTGNIFLDNVECLGNETNIGLCKSTGINAHNCDHSEDAGVVCFNYTETTVPPPASTPSEVSTPKPTKSPATTKAPTQLPTTPPTKPPTAPPTKPPAPQPATSPKIEFTTKLPTTQVKEVTTSQITPTPAIPTKLPGSGEKRDQKDRKTKVIIAACITIVLAIVLAAVVVFLVYKYRLRTKPSIPHERFHDDIIEHSYDGSLTMQNQMYSMSQGDPDDPVVQSMNDGSEILMDPSGSVSFSKGTTSPEVDDDAPQEGFSNPLYGVMKNSAETSVDAVTVDMNGSEPSNQTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0D5</accession>
    <name>A0ABM1A0D5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Glutathione S-transferase class-mu 28 kDa isozyme isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101853318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938257.1">
        <property type="nucleotide sequence ID" value="XM_013082803.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938258.1">
        <property type="nucleotide sequence ID" value="XM_013082804.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853318"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="126"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012938258.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37732" checksum="F933F15DE8809FBF" modified="2025-10-08" version="1">MRRRRSYQKKRPQAENEEETTSLNDRVGSTSRLQLAIVLPGAYVEWSGSGGQNTALSHLWEVRRRFSVRTAEFGEDASDKEFGENKTPRYSDDMFTHMKMEIAAEKAAREFIAQKIKEDSAEWARAPYQLVSFEGKGQAELIRLVLIVAGQKYEDVRVAEDEWEEMKDTTPYGALPILVKCNVKWGEASAIVRTLAKKFLLLGSTNDDHLITEATFERLRRLQLDHKKAIKWATSGEKNKERLEWAKSQLTHVILPEAFKEWEAQILSSPGPFIITNGMTVADIAIMDFVDQCSTNLVITPILADFPAVSDLLTLVRRNPRLQAYLDGRAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0P7</accession>
    <name>A0ABM1A0P7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011873</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938449.1">
        <property type="nucleotide sequence ID" value="XM_013082995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011873"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938449.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14752" checksum="A8AD5A2891B085AA" modified="2025-10-08" version="1">MRSGPNSYIVQGNNGFVQQPVPGPQNVVNDGGTADLYDMEGPAYYYYFYYDDDNKVPNNNLPANVPGALLGKAVEDFQPDMKVDENIVKVEEGSKIADGVDASNQVHQDGIPAGNDSENSVNEVNTDEAELSSLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0Q0</accession>
    <name>A0ABM1A0Q0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="11">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">LOC101848205</name>
    </gene>
    <organism evidence="16 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005099220.1">
        <property type="nucleotide sequence ID" value="XM_005099163.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938452.1">
        <property type="nucleotide sequence ID" value="XM_013082998.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938453.1">
        <property type="nucleotide sequence ID" value="XM_013082999.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848205"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBINO" evidence="15">
        <location>
            <begin position="248"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="482"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1109"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="965"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1333"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1393"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="975"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1347"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005099220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012938452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_012938453.1"/>
        </source>
    </evidence>
    <sequence length="1472" mass="168821" checksum="44E0601D2399A070" modified="2025-10-08" version="1">MTTETAAREHNYGRLLAKPLHIQQLEAALNLEPFMKYVENALSENVDDITDCDPSDTEADILKSSLRDNDDNKIVNGITISKYERKADKTRLYNFSKVKKSRRWIRNILLSDTSSDEEDDKLMKMEDLHFMLHMHKQRKKHQMKFYQDPDLRQYQYYSTGLLSNYDKYPEHSKSIVGHKKKMAKEQKKQEKKAKAKLKKLKKESTLDEDGEEIDPSVLEALLAKRQEKREKKPKKLTPEQADAKRRKLWISIAKKEIPRAQKQKASARKEMLATMKKISTQAMRECRRASLQSQKTMKETPSRARRLTREMLIYWKRFEKVEKEHRKRAEKEALEQRKLDIELKEAKRQQRKLNFLITQTELYAHFMARKITGEGTERKDKILGQLDERNRSTKSSRHVNGGVLEDELLDDDYDGEAMKKMALDHAESAYNMHQTQRKAFDSDALDKGLSEPTLTGDAQSAQPDMFNGKLKGYQLKGMNWIANLYNQGINGILADEMGLGKTVQSIAFLAYLAEVQSIWGPFLVIAPASTLHNWQQEVSRFTPKFKVVPYWGNTQDRKILRKFWDQKSLHTEDASFHVVITSYQLVIQDVKYFQRIKWQYMVLDEAQAIKSTSSVRWKILLDFNCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHVEKQSGIDENQLSRLHMILKPFMLRRVKKDVENELSDKIEILVYCPLTTRQRMLYRAIKNKISIEDLLYSSTSSASSAQSTTSSLMNIVMQFRKVCNHPELFERNEPKSALCFPTSPLVVPKLVYREGYLEDCLPSRHHIVFNMLYIFSPDNIHRSLFGQSSEPLADASSQSCFSFSRLINLSSGELHAHMYGGLLVRWLGVFILMKAAYRIHQHFVWQEEKSFRSRDCLQLTPLQTSSAPSISLSPVLQDLVFTSHTSRLISHESVVLHYIPETFAHRQIRLKRLRQLALSKKNPLSPPHSPTKSPVRSPSNEEVNLPLHPHKLRPARVLKCQPIDVPSFFSILIPKIACPSRSEYTVDRSAQWQLMRRQLCGTLKAKQSLLYGEPEKAEYERWPSHYFSPLEHAGLCAFQPRYGWTHVQIPDKESLVSDAGKLFVLDSLLRRLKNEDHRVLIYSQMTRMIDLLEEYMWYRKHTYMRLDGSSKISERRDMVADFQTRSDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGSIEERILQRAKEKSEIQKMVISGGNYRPDSLKPREVVSLLIDDDEMEKKLLTRQFEKIGDDPNMGTIFRKRKREYKKREGTKKKKAAAAAAAAAAAAAAQAEENNITIPAPDTESVASRDSFSMPASPQSGKSVGSEALSVMTQDDSNEGGLVIVDDAHSLFPPVSSKPIQPPKRGRGRGRPRGSGVGKRPRGRGSAKKAMSAAEIAGAQAGMTAAYAAYGYNFTGKGKTTVQSSKPPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1A3</accession>
    <name>A0ABM1A1A3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium-activated chloride channel regulator 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101864624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938799.1">
        <property type="nucleotide sequence ID" value="XM_013083345.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864624"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041940">
        <property type="entry name" value="choice_anch_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF177">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047472729" evidence="2">
        <location>
            <begin position="26"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="931"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="340"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938799.1"/>
        </source>
    </evidence>
    <sequence length="978" mass="108322" checksum="C728F10CB843E883" modified="2025-10-08" version="1">MAMSRLQTILVHAFILWIMTSTTRAVVRPTAITIEDNGYKNVLVAIHPSTKESSSLVDYIKKMFTEGSIYLYNATEKRAYFHDVTILVPNTWADNAAYQQATSELYSNADVVVRDPIVNVEHRDGKTVGNSTTEGAFTRSYGGCGQHGVRINMFTDIFGARGKYKYGPSGRLLVHNWAHFRWGVFDEFSQEGEPQFYFSPTTGQLEAVKCNINMVGRIYKKTAGGAADVCSTLDPVTGMYPDDCIFDPYTLGHRNGNISSSIMDRQKVPSIIHFCNDDRSNLKRVHNYESPSRHNRLCGSRSTWAVISQSPDFFGGLNAPRDIHDTTPKFKVVRLTSSRRMVMAIDTSGSMQDDEKLIKARQAATSFIEDGLDDGASVGVISFAKEVKVMSPLVKVDSKESRKNVTRKLPTETGGETCIGAALLKAIELFKRHDENATDAFIVLITDGQETSAPTVDDVLDKVKAAGAVVSVITFSDDEDKNLERLAQRTGGRYYFDNNMQSSTAAVDAMLDVYSLFNSGNRHLPVQIMSQATILKQGAVMQGSFLVDESLGKRTRVIFTYTDQLPTIRVTSPTDRIYCSLYPEYEHDPFLKRVKITIPFSAENGRWSYSIRNEKSYREKVSIMVLSSSVSNDRMHLRFTGSILVQNDTWPIRSRIVAEATRGERPVKNLKVVATVDRPSAEPVTLELFDQGAGADIVKDDGLYSRYFTRFTADGRYTVRIEMMTSEGDVLVTGDMDFKMASFVASAYAGSVHVTHPRLIGPHHSEVIPDVTVDEYPPMRITDLRVLHTERINGSGIVVLAWTAPGDDADIDTAESYTIVVTPRAEDQVGAQRKSLPAIPPSAVLKGSLDNPKPFGEREEMVVQMDVPKGQNVSLVFSIFAEDESGNKGELSNLVTVGFGFVPDLTTREYLSEDHSEVAKDAKEAPHSQKIVIAGFVGSVVVVLVLTVVISIIIQVVQNKKKKTKDAFEEGNKKSFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1C0</accession>
    <name>A0ABM1A1C0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid synthase</fullName>
            <ecNumber evidence="1">2.3.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101859645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.85" evidence="1"/>
    <dbReference type="RefSeq" id="XP_012938829.1">
        <property type="nucleotide sequence ID" value="XM_013083375.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859645"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="868"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1997"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="868"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="908"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012938829.1"/>
        </source>
    </evidence>
    <sequence length="2577" mass="287085" checksum="D95C49477AA8C340" modified="2025-10-08" version="1">MTASVPGADNVEQFWRVLEQGENHVVEIPKERWNNDAFFDTDVHAVGKSYVKRAGLLKDPKAFDNKLFNINDFEADQMDPQQRFVLECCFMAMEDAGITREQLAGSNTGVYVGAMNGDYRALFTAKSPIVGNYTVTGISNSIISARVSFTFDLRGPSMTLDTACSSALVAIHVGAQALRTGDCDLALCGGTNFLMSPDVFVHLSKAHMVSPTGQCFAFSDSADGYTRGEGCGMVILKRLKDALRDGDHIWATIETGSNQDGHSVTPISAPSGDQQLRLLETVYQDAAMDLEGIDYIEAHGTGTSAGDPVEAKALGTFFRSKGTTRQRYIGSVKTNVGHLESAAGTAGLIKVLLMMKHSKIAPSLFFDRPNPKIDFPDLNLQVPTKAMDWPRRNKIACVNSFGFGGTNCHAVVKAFVEHDLMRRSSQSEVLSIPCIVCFSAKHEKSLKGSIEDFVQHPEVSSLDVHDVSYTSTVRRDHYNIRFACVIEDMSELLSKLNDHIQKGEKGIVANRRAKAVFVFCGMGTTWKGMCKEMLDESSAFRDAIVQIDEYLCEYVSWSLITRFEQESYFDDPEFSPIAIFACQVGLGRVWASLGVTPACVVGQSVGEVAAAFFAGILSLRDAVKIVYFRTTLMAKVIGGKMVIVRNMLVSKVKEVVKNFQGLANVSLEYSPVACAVSGNNNIITQVKQELQSKARSIGAQIQLIDLQVPVAYHSHHVDGCKEDLKQALSDITPNPPDVDMISSVLAEPVMGPLDADYWVSNMREPVRFYEAVQKTVTKGSKNVYIEIGPKPVLRAHSGDIFPQDIVVPIVSMYKQPEWKIFLQAVVSLYEQGFNIKWKNLPTKGTVVTCIPRYSFNPRRVLQLCESAHMILSGVHYMRKEHPFVYKVDTTNEFKTIITALTFPSVYDHIVSGMLIIPGALYAEIGFAVAMHNDSMDAPLYSVSVRFEQPCSFSRDGAVELDIEVKPSPAKGVGVEKYQSYKLAAVQGNKTFANIHLQAHNMPKHSPAINIRHIEARCTQMVKREEIYDSLKSFGFTYGPGYSLLMYALKSSQECLAKIFVPRAMFMEIGGTTIHPSILDGMVQTSVLLMNTMDEARDLLPRSIGKLTCYRPTEEEMYIYTTLKCSDRTLTLYDIKLTTLWGEVIADLEDLAIKSLTDKSDAVQDMYRCYWKLQKSNYTGEETKEPKALYVTDSVPEGTPTALMKRCLVYDPQEQTSDYLQNTLDTMLKNTAEPFELIIFLPNLKMDDSEDAYDVHTKILNSCMLLKFLYKYAFDKSLTIPLCLFTQRAFLPEDVTTETENVNPLMTALWGMTRCVLKEQIYTNFASVDLHLPEGKLCLDFVTSITDLILSDEALKGYPEFMVTEKDIFVNQFIAVEPDTVVPTFRHNFADTSQNVIFLSREPSVLTDSFAVYHKPQEKVEQASYISIDVSTTAFQSPLLYNMTMLYSTMEKRISQKGNGYPLFALENIGTGNAPVNGKKQTDHKVPLISCYPVPTGTKIKVPASTTVTADMIPDYVPGDLSRLVLLWCLQDLVLTPTATILASSATAKFGEALLCMLMSRRKPKPVQMNLVVVEELNNVESMGETVVSLVLTEETVVPILAKRWPMAKHFITVSSLLQDSARAPIAFFLPSVQVDLLDTNMVFHPQNLASTVPKVKKWMRKHASLMNRVAGCLHKAPSSYPVFKTAVSDLDELLEVQIIQMKSPLVRMEKSELFRQDAIYIVVGGLTGLGWLFVKFLSSNGAGNIAILNRRQASAEQNKDIEDLITAEDCNIKAFQGDVTNLDSLKTSFKNMLNSFRGSVIKGVFFGAAVVNDQLLVDVDPKTFSKVLAPKVMGVWNLHQLTKDLPLDYFIMHSSITSALGNAGQANYGAGNAFMDGIAHYRRHKKLSGQSINWGALDTGILSNYTEAKKFLENQGFILMTEEDITAVIIPILLLDWAQIVPCTFDEEILVKRVKRDMLVPFQYRLMSMLGSATEEVKIEEDILLALKTARELPPDQRVDVYERYVTALATQVLSAEDGTIKTDTSLIDIGMDSIVGMTMINQIYKELHCRLPAIVFITNDPTVRSIAQAIDDVLSGKMAEGSEFGPDMEQLAIAAAENESGDAPMKKEEVPALPAPPEKVKSFTASVVESSQLVIYKRHPRKSYLHGIVDVELPKARQDPEALKLAIIKVLEMHPAACFAFKEDSSKRNTIFNFEKKILSPEEAMDFRVMPSTEENLQQYCEEVFEFKGKGPMRFIMRQGNRALVRIVFHKAVFDFRSVHSFVKDLSAILHSEDNKPPTEKIQPDKYIIRQDDLSTELNKVYKSKSEALTHFWAKTLNHDVGNTSLKAHKIQYPPKPLEATNAAQRILLSPDLTRKLTAFIRTHKVSLLGIVASCYQILLHVLTGKSTLSLIFPVDLRRFNKDISGNVGNFSNEIPLPVTLDSTTKLTLVEFIVANNNKVQQHIDHGMLPFTYFQSLAERVMEVFHQSPHGICIEMTSPENIQYVMSKTTHQPPVLPIGMETNLFVQHHLHSGIVSLDLGYKTCLMSGAKAEVLLKNMAALLTCVVDKPKLQLGNMKKYTDDLDTNFDTKGSCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1C5</accession>
    <name>A0ABM1A1C5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101858035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938838.1">
        <property type="nucleotide sequence ID" value="XM_013083384.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858035"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012938838.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="58767" checksum="576DE70081C0A4ED" modified="2025-10-08" version="1">MQTCTYETKAIVTGYVAKYCKEHECNDTSKIQKVDVPANVSHCTLSGLTTKQTYLLTVQSKSHRRFGVEAHPWKSAIVREGNEEASNVPLIIVITAAVFLVLAVLAVAFYMTRERCKKFKSLTLEQDFKDVILKDNPKRTPASSFQGNVIPSSECACDVPPEVPQRTVVSNSEPSVLFEVQDESVQDQADVTSGPDSSWWDNSGAPLIKEPVKGDKQKGKKNCKAAKTIPIDVVEMTDSPAGGSTVVSPSHSCHSNVELLPAESTAPTGFTVQENACPVHSVSKLSDATVITPSTVLVTHVPSQGYITGSNQQSLHCSSSSSSGSSRQNVNEYVVSEQSARPKDRPEDSDVIEAINFSPDYVTADSPSVLADSDLAVVPEVKVGRKLTEPHDMGMTSPSTGVYTNKLPLTDVDFPEERETQLTQGNNDQLGEISYSPHPVQAVALCEVGLPMYVQSGGGGTAHTASGVNGEEESLQRHDVGCLSLLDTGGVNQDRLCDSASDSELGSFDVPHSDDEGHNGEESSDEDRHYYDNRDNDDGYTVHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1C6</accession>
    <name>A0ABM1A1C6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch-like ECH-associated protein 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101860336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938839.1">
        <property type="nucleotide sequence ID" value="XM_013083385.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860336"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF401">
        <property type="entry name" value="FI11917P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012938839.1"/>
        </source>
    </evidence>
    <sequence length="646" mass="72759" checksum="B8484AC4B088C27F" modified="2025-10-08" version="1">MASNFHHQTSASHRQTSSRTGGAARLEGHPSATRLRPLRYNDARPQADDPQTEELLERMRRQMPTSCYMMRPLLTEHGVDGSTRFHIYKYPTEALAAMNEFRLEGSLCDITLNVNGECIRAHRIVLAACSAYFRAMFTNGMMEASCSEVTIREPNITPPTLRILVEFAYTHEILVTQENVQALLVSAIFLEMTHVIEACTLFMEQQLEPSNCIGFANFAAIHGCLDLEAKAKKYIHEHFCEVIKYDEFLTLEHEDMINIVKQDELNIRCETQVFQAVVRWVEHDTDRRLNQLVDLLDKVRLTSMAPCFLENQLEKCTVIKQLPHCVQLLLDKLRKLQQHSGDTLDRPRKPCKPLVVYSVGGFYRKVMDSLKCFECYNPVSKEWTRLPDLPRPRCGPGVTSLQGLVYVVGGRVMRCGESVDSCSLDVYDPGQNMWINGNPMSVARNRVGVAVLDNMIYAVGGSDCGEQHKSAERYNPESDSWERISPMSTVRMSCGVAVVNRLLYAVGGYDGRNRLSSVECFHPEDNEWRLVEPMNEARSGAGVVVLGGCVYAVGGFDGARQLQSVERYDPVKRCWDYVASLQRARSGVGVAVVDNKIFALGGFDGRDFLPCVECYNPELDQWQSETIMLCERSGHGVAVERQPTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A276</accession>
    <name>A0ABM1A276_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Aminopeptidase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15" type="primary">LOC101846821</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939329.1">
        <property type="nucleotide sequence ID" value="XM_013083875.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939330.1">
        <property type="nucleotide sequence ID" value="XM_013083876.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939331.1">
        <property type="nucleotide sequence ID" value="XM_013083877.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939333.1">
        <property type="nucleotide sequence ID" value="XM_013083879.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846821"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="10">
        <location>
            <begin position="473"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012939329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012939330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012939331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012939333.1"/>
        </source>
    </evidence>
    <sequence length="627" mass="70943" checksum="EA6E4185563C979A" modified="2025-10-08" version="1">MGLHADSAEDPATASNFREAVSSHLHLDVDVDFDTQTISGVNRISMECLTDGLKQVILDVHEALTIKKVTTQRTRDVDFKIEPFDIYGQSLVLTFPQAFAKNEKFDVEIEFVTSPSPGVCWLEPPQTTDKKLPLMYTQGQAVLNRSFFPCQDTPAIKVTFSANVKVPDGFTPLMSANKMSTGEKPNRKGETDCFFFEQEVPIPVYLVAMAVGDFVSAEIGPRSKVWAERSMLDKAAAELRGDVEEFLLAGEQLFGEYVWTKYDILVMPPSFPFGGMENPCLTFITPCNIVGDKSQNKVVIHEISHSWFGNLVTNASWSDFWLNEGFTMYAQRRIEEKMYGKAYMCLEAATGQALLNRHIDREGTDHPLTKLRVVIDRGVDPDDTYNETPYEKGFCFLSYLCSLVGSVEVFDVFLKAYVDKFKYKSVLSEDFFDFFLEYFPRLRDEKVDEKPGLEFVATWLNKPGRSPYCPDLSDKKELTAEAERAAEIICDGRRKGSEAPDMSLWKAYSVLYFLDEVASKSPLPAGCMKKLADTYPFLSASHNSEILLRWCEVVIKNDAGNFFQDVRSFMKSQGKLKYTKPLYSEMTRGSDAVRHLAVEIFRETRESLHVQVREYVASLLKDAGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2D9</accession>
    <name>A0ABM1A2D9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Noggin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the noggin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939437.1">
        <property type="nucleotide sequence ID" value="XM_013083983.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851272"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.520">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008717">
        <property type="entry name" value="Noggin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10494">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10494:SF16">
        <property type="entry name" value="NOGGIN-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05806">
        <property type="entry name" value="Noggin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047239323" evidence="6">
        <location>
            <begin position="25"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939437.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28798" checksum="AF0FAC63736A43D8" modified="2025-10-08" version="1">MLIMPVLLLLLLKLCACQSAGAQAAELSFRSLQTDGQLTDDDAALYFPLDGSKKNIRRPLPSDSLPIEDLVEDQNSIYDPRDEDMNVKMLRKQLGKNYDKKYMSIYNPKKRMNTDTPLISFVQGRPKGKRPHFLRRLRTARLQDGRKIKLNASKRDRRKFQKYMWSLTFCPVKHSWKYLGIRFWPQWIKEGTCTSKRSCSVPEGMTCKPSASTNKTFLRWHCADFEGRESCKWIPILYPIITECSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4Y3</accession>
    <name>A0ABM1A4Y3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940916.1">
        <property type="nucleotide sequence ID" value="XM_013085462.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850350"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18505">
        <property type="entry name" value="BACK1_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18506">
        <property type="entry name" value="BACK2_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18308">
        <property type="entry name" value="BTB1_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18309">
        <property type="entry name" value="BTB2_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="395"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="606"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940916.1"/>
        </source>
    </evidence>
    <sequence length="788" mass="89239" checksum="D00CB774FDED7399" modified="2025-10-08" version="1">MAIARPPGMDFDHNWPESTECLTLDFGPFETVHMWKPMPECDEFVGARRSKHTVVAYKEALYVFGGDNGKNMLNDLLRFDVKDKSWGRAFTTGKPPAPRYHHSAVVHESSMFVFGGYTGDIHSNCNLTNKNDLFEYKFNTGQWLEWKFDSRDDVREPMSAKSHSRTVGRSQRMPVARAAHGAAVYGGKLWIFAGYDGNARLNDMWTVSLLGDIKEWEELHQSGDIPPTCCNFALAVARDCMYVFSGQSGAKITNNLFQFSFEDKQWTRISTELILRDTPPPPEKRYGHTMVAFDRHLYVFGGATGQTLPNELHCFDLDSQTWSITEPARQGDTPQIPAGRLFHAAGVVGEAMYIFGGTIDNNVRSGEIYRFQFSSYPKCTLHDDYGKLLESRQFCDVDFVVGEEQRRIPAHIALVAARSHWLRDKIRTAKTQSSYCPDSGKLEVFLVDKDPGAFEMILSYIYTDKIQPSVKGAEGQDCNNHVILAMMEVYRLSLQLHMGRLQQLCVQFLEASIGIKSVLFALHNAARLQLDFLKGFCLRFIVKEVNYNQIVMSKEFETLDKPLIVEIVRRKLEPPVRLGDPQPEPLASNSLEQDLAQFLVQGQEFCDITLVLDGTSIPAHKAVLGARSSYFEAMFRSFMPQDNVVNIAIGEMVPSRQAFDSLRRYIYHGDIVMPPEDSLYLFAAPYFYGFTNNRLQAFCKHNLEMNVSYQNVIQILEAADKIQATDMKKHALNIIVRHFTKAARQASLRRLSRELLLDVLDALADEMGDSRVCQDLSAVSLTDSNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5R9</accession>
    <name>A0ABM1A5R9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101852641</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101852641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941362.2">
        <property type="nucleotide sequence ID" value="XM_013085908.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852641"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="77"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012941362.2"/>
        </source>
    </evidence>
    <sequence length="339" mass="37469" checksum="A4A4297BEEC3DFC6" modified="2025-10-08" version="1">MANNDNNIITTRTSDVTLLGWSLLRLHQPNSSSPAPRAGVTALPVYVSPISFEARVVVLAVNYNFLCMIICTLGTAANVLNLIVFKKQGFNDSVNVSLFGLAISDLGCLLTLLWLSICHNPLFYNLDLPFDPVEVQYVTAGRPYLLFTRISSWITTFVTLKRYLCVTFPMKVNGLITPRRTAVVIVIIYVLFAASVAPVYYISRLAWRFNPARNRTILGLVFTEDREAIESVSFTVNNVAIQIVSLVCVVACTAALVVRLNRRTSWLRGVASDSSSSKDKKVVKMVVVIATVFSVSFTPITLINVGMVLDPQFTTVGRRENLFHIVCSFAFVLEAINSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6B2</accession>
    <name>A0ABM1A6B2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846023</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941652.1">
        <property type="nucleotide sequence ID" value="XM_013086198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846023"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941652.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35456" checksum="EDEEC09AEE98DFBA" modified="2025-10-08" version="1">MPRSQATPAPQSRESGRSEPADEPLSGVAREALEAPPGPAGAVLMNKVRNYLSKTGIEEEFHNLVRKLLSRDELPYNPYPGIALRLRPFMEKFYMDADTDDKIEYSLSVPLRETKILGLFTAQEGGPVWGLRSILRVSDTTMINRYRWLSDNITPNFNDLYQRDGYSNQVMVALVGAAIFHGSFYRQVHIAQYRLEFLVTGKHADEAVSIFVNSVILDVDKLSESPHHTLIGLNVPVQVSVTGGETEEEAWLLEFWDQPTIQAHKGELMQKLSDAVIGNKYILAECVFQLDPHKETYIQGQKQYTLNFVEVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7S9</accession>
    <name>A0ABM1A7S9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Degenerin del-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC106012861</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942493.1">
        <property type="nucleotide sequence ID" value="XM_013087039.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012861"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012942493.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51678" checksum="EFBA647BB43FDF64" modified="2025-10-08" version="1">MGLFQEFSESTSMHGLQRAVSSESKWKRPLWAALVLTGACLATFNLSQTLKDFLHNPTTTQTKVYYNPKMEFPVVTLCNLNPFPVTNLVAEMDFMTMSNFWEANNFKLEDVMESIVQFQKSQNVPITFKLGDLVTDCQFDMVPCRADDFLTVFNYKYGDCFVFNKQIKEDSNQEYMHSSEAAGFKVVVHSQDTIAFPENQGFMVMPGASTSVGLKRTEMSRAPPPYSTCIELEDEYNIDLNVFSFTDGTRYTGEACRKTCYIREVVSQCGCCDLYFVCPPEVYNVYVVNETIPYCNATNIDDFFCKKRVLEAFEKGELDCLSRCLPPCDEVVYDVALSTALWPSDSSIYFDMESNDGSDIAISEFEEFKSHARDNFLRVAIFYEDLTVQRVESRPSYDWNRLLSDIGGQLGLWLGFSILTAAEWLELAYDAGIRAATRKAQGAHTTKVHVQEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A840</accession>
    <name>A0ABM1A840_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Papilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101846981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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</entry>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012942698.1"/>
        </source>
    </evidence>
    <sequence length="3570" mass="391451" checksum="314E8EAEF7B98325" modified="2025-10-08" version="1">MVAAGGTTTSGFRLAAHAMAASTKQTCARILCVLVVLCTLTAGQLEQYDLTLTVREDVSIGTVVGVVEGDKYSPPYSRLIKNPATDNMTLSSFDVDLSNGRITTKDTLDREEREKHTIIISTFSQPTQLVIVEIRLLDINDITPTFINPSLVASIPESAPRTHKIALGSVRDEDLGDNSTQTVEIVSGNDGNTFFLQIKNSSNVDKILDLVVNTDHLDFEGKKVYNLVIRATDGGGRSSDMQVTIRILDTNDNEPIFNNSKYSARVAENVTVGTSIIQVEATDSDSEENSRITYSIDPKTDPEEYFSIDPRTGWVKVRKPLDFETKPQFVLTLEATDSGSPPLSGSTGLDIIVVNINEQPANISMTFKPDFRNGHVSEDTPVDTVVAVVTIDDPDTDVVRNVEVSLYGGEGYFQLIKTNRLEGNELDLVVLDSLDRETVPAYEMTIVVTDVGTPPLSANREFRITVVDVNDNDPVFLRSKYSADVEETAEIGKSVLKVSATDDDFGDNARITYRIQDGSSHMGWFTVDSSTGVVTTRASVDCELSPQLLVIVATDGGNPPRMATAQVSISIRDVNDKEPEFETSFYSIKIAEDRRVGDCVLTVSAIDPECGASAPVTYRMARMLAPLREFRVDALTGDICVQAALDYELTTSYQFQVEAVDAGNLTSQAVVQVEVKDVNDNHPRFEPNRYPINVVSGVAPGPLITVQARDLDSGHFGTATYSIIYGNDQGFFSVNADTGAVSLDQQLPPGERVFRLHVLATDGGGLTSPDPAQVTVSVISGAVHPPVFSPTMFNFSVAEDALPGRVVGQVQATLDDTGGNSEISYSITFQTESWFQVNSSTGKITTSGQLDRERHAFVVLNVQAQAHFPHVYAVAQVNVSIQDVNDNAPSFPPTAMLELEVREDEAPGTPLYVARARDLDTQNNGVIVYQLQKVPGNLFSINDQTGEITLMDALDYEKHKEYQVLVMAKDMGSPSLNSSMNLTVKVKDINDNDPVFDKAVYDFHVAENVEIGHVVDQVLATDDDSDHNGRISYSFVDDRHASTFGISLVEGKIWTRDLLDREIHDRFEMIVQAVDHGSPQRSATVLVRIIVTDINDNAPEFSREEYRFSIEENLPANSLVGKVVAVDRDSGNNSRLEYFFSGPQTNFTINPQNGEIRTRIPLDRELVASHVLTVYVSDSATEPKTAKAKVKVSVVDDNDNQPVFQRQGPFSESVSENRPKGTEVTTLVALDYDQGDNGLVTYFFDTDWSEPEALENFAIHPRSGKVTTKEVLDYEVRSTYQLRVVAQDGGSEPRQAAQLLTISVLDANDQAPLFHARNVDFDCVENVSVGTVVGRVEATDRDSGNNGKVSYYLVGGNVFSSFSVNRSSGVIQTVREIDYEESSSHTLSIQAYDNSAALPRSSNITVTINVIDVNDNAPQFEQDPVIIRTVAENTRENHVVHTFIATDRDSDVNGTVRYTIESYSGEEEGLGPYFSIDALTGQLYVSGHIDFEKVDQISVIVRAEDMCPDRDHRLHSLMTTIVYVTDINDNAPEFESTDQLTVSEEEAVGFMILVVVAVDADADVDNSGNNRVRYSIVSGNRDGKFLLGEDSGYLTIYDALDHETQASYTLNISAEDSGTPKQVSHQLLHITVADVNDNPPIFVQSVYHANISENASPPTHVVTIQATDADTGVNGELRYSIPSGIAEDEFVVEPITGAVNARMALDREKRDLYTVTAYVQDGAYPVHYSSCTILITVVDENDNRPRFKSQTYTVQVPENRVRQRLLSVVASDDDLGENGRITYEISNDYDGKFSIDPEHGHLSSEPLDRDTTPSYKLIVSARDHGSNPHTATATVEVIVLDENDNSPTFTKSVYTGRIREDVGLGEVVVKVSAHDPDLGPNGAVMYSLGNDTEGFFEIDSATGEIHTSGSFDRERNQSFSFLIVASDNGTTGPRNSSAQVDVTVTDVNDNAPVFSEVPYTSSLSLTTPTNKLILTVNATDRDLGLNGQVEYRLQAYDSSRDSLQYFRIDPTSGRVYTNKSLLLTNAAGHHSLLVVATDSAASPSARLSSTGVIEITVGSESSEQFKFTRSEYTVEIDESLGQGQLVTEVQAGFSGQTSTAATYSFATGNENNAFSMERNTGQIRVQKSELLDYDTNPQIRLIVSASSGSHHAYATLWVNLKDINDNAPRFSQSRYVSAIWENNQPETFVTQVTARDADSGLNGLIDYYIIGGGEKVFVIQDSLTGIVQTHIEAAPLDREARPEGYRLTIQARDRGTPPKTGVCTLLITIVDENDSPPHFPDIGPLNVSENRDVGYVVAMATANDVDLNPILVYDFTTDGNPDQTFSLERSTGRLTLAKRLDHEKKSHYTVRIQVTDGKPDHTQDKWLDVYVDDENDNPPVFSQQSYEVSLPEQTGPQQSVVTVLATDADSGRNKEITYSMAATAVDSFYINSATGVIYTNRTISFTSGESIIQLVVVARDGGSPQQSSMVAVHIQITDVNKFTPRFLNPSGYEAHISESAQKGHLVLQVTAIDEDNAHRGDNINYTLVGTGSEHFHIRQRTGHIYYSGGIDYELRTRYDLTAFATDRGTPPKNSSVPVTIIVDDENDNAPVFVQERYSITLPEDYPPLKEFLRVNATDADSGLNGELRYSITSGNSEGIFINRDNQGGLVIMEQMHLDYESHTSHRLILRVVDCYRCNQTAPRLSAFVTVDIFVTDVSESKPLFPMQHYEADLPENSPRGTVVFRAHANHGDRGDAGRVTYEFLNEFSNEFSQTSQKFEIRPLSGDVRALYEFDFENPNLPHLYNLTISARDTSGNLDVADVTIRVVDMDEFDPLLTAQEYNFEVPGSAKAGDYIGHVSATDLDEGAAGRRVYSFLEPSDYFTINEATGNITVAVTLHDDPPPVRTQTSRRKRALTSDTEHLTIQVSSGQPGSRVGTAQCSITIDRSCPGCAAPVGKLRADEGMDGGVLAGIIVGCIVVIIITIAIILFFIYRRRSPRKAVPNYSSDSTLDLEPPPQLPHDRTFHGDVIRINRPPQGNHLVSDISDQSHNSASSGRGSAEAEEEDEEISRINSSSFLHSSQAFRQKAMPDSGIQHDDDTLSEPTAQTHQEYLANLGIDSSKIGKTKSSNNTNNKQLGRSAESMHQFSDEGGGEGGVDTDFEKMTDLETDDEAATLEARTQGMSFHEPDTANVGSLSSVVNSEEVNSGSYNWDYLIDWGPQYQPLAHVFSEIAKLKDESITPKKQPIKTVPQRQFSSSLKQPQVRTVPPPIITNAPPMSVSLPSATTSNPSSGEAPDYAPPSPPVPATRRGGHPMQKPHPVPHHNHHHHNHHHHHLPHTHAQHPIQQMPLPPIPTQQAPLQGPGITSHLPLSQPNTSGYSTQQQQQQQQQGQYEAPPPAYNQLYNPAYPKMGSNNHHHHHHNNNNNSNNVAGVGYPHPNNSRSPQVARHHHHPHHSPNVNKHNHFHQQQHHHHPPPPQHPPPQPPSHQQQQQSSSGSRSHPVSGHASTMNTSLPSLPRSPISYESSLTSAAMTPSLTPSLSPLATRSPSISPVVSSGHTTPGKSSSRQNLTKRSSNSQSISSTNSEKEFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8Q2</accession>
    <name>A0ABM1A8Q2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Ferric-chelate reductase 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC101863538</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FRRS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the insect defense protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942974.1">
        <property type="nucleotide sequence ID" value="XM_013087520.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863538"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09628">
        <property type="entry name" value="DOMON_SDR_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF9">
        <property type="entry name" value="CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="8" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 20" id="KW-0732">Signal</keyword>
    <keyword evidence="10 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045900865" evidence="20">
        <location>
            <begin position="31"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="23">
        <location>
            <begin position="25"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="21">
        <location>
            <begin position="222"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="22">
        <location>
            <begin position="351"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_012942974.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="68469" checksum="C3500E227506E6EF" modified="2025-10-08" version="1">MTMTLMRMTVLSNKMLLLCLLAVWAPWTEAFPSGAPAHTCMTMFPKHNGAESRLGTPPFEILPSSMTYNAGERIPLTISATGTEQIKGVQIKAIRQSGNTEEILGQYDNLQPVNKLRYINCQEKQRNMVTHNNSMEVSALTVTWIAPATNEGPIYFDVTIVSSYTVFYFGIKTPITPGPTLPVFVPQPWSTVSNSLSPINWDTCGDDKGCMLYPAYCSGDDCKAAVSYAFNNDNDTVTFEMMAESEGYVAVGFSHDSIMGDDQTIICTAYFERVSIQNGYNHHNKYNVRDLRTNLTNLEVAAQRDGKIYCRFSRPVSMELLLEQGRSLVPMTFDLREEFHLFLAWGHIYSLSDVIGFHNEAPVISDAKVDFTDNSNVIGSVLPKLVRAHGSLMTIAWLGFAVLAIVMPRYYKDGFNDKKICGIKIWFHIHRTAAIMTFALTVAGLVLILVKLDGEVTERKSAQTHMYLGFTVVALVCAQLVGGMLRPGPDGKVRPFFNVFHKLLGSAALIIAAATIVYAYKMSEFSYPMQRFGERTVAVWAGVLVFLEILLYAHQYLAPKFLGRPARTDEYNVDKLSNDLEPTETVRPSNFLLVLVLIFVIASIISALYLIIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8Q4</accession>
    <name>A0ABM1A8Q4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA N6-methyl adenine demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942978.1">
        <property type="nucleotide sequence ID" value="XM_013087524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846764"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1332"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="525"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="942"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="979"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1332"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942978.1"/>
        </source>
    </evidence>
    <sequence length="1353" mass="151404" checksum="9450614534D7B980" modified="2025-10-08" version="1">MDEVEKRVLSQMRSRLVKEVVVTESFLSAFCDCNVLDDQMTRLLKTERDYEQRACRLLELLPGRGNKAFYTLMEILEVTNPWLTEKIKAALHEERNRDSKINIHPSVSQNATIEGYGHSRLHIDTDIKERATRYVRSNLNHLTEVEQRGVDKWLADELQRERRRQQFRAPHNLPRHPCEFQSTKESQTDTTNMDLREMYEEMIIYLHGVDYVEISADFSFDLFQTQVKELLTRTRKMDVLFLNCLDKFDDCDKYSMGLPELIERHVTHERDRMRNAMEDDRKLRQKAVEEREQAKRQVKRLEDELERLVQKQSQLVKPQEIQLTHKHNVGLRYSLIVPEQTHRNDVPFRSTTAAKADSNPTPPDSTQNSAPPTPPVVTSTSINVVYTEPTPKRAESLTNVAPPPAPKIRRHASEESLKIALSKEDAETTSVSQLNGVGCGASQQYLMNMHRARGKAFQDSNHNNNAKQQPPSSQSNHPSQQQRTQQHPQQNHQQQQQQQPVTKQQSLQRQSRADLQNKMARMLATSTSVSSSKSKQPTTSSTNSSSSTTFSSSYTSTSSSSRPTKRSESEKAVPTHGGGASSYSNQWRCNDPAQMFRGNPSLQASYENIAAASRRAGGGERVVYGSLDTPNIVVTPSGKGKGHSDGYGDREQQQQSHGIGHSFKNQHHHNNQPHQKEYDPVYQSPIARSAPTQQRPSNHHNNGNNSNKHHNNNNNNHHHHSHHSPHYQQNPKQAYPDYHHNHNSNTNSNNNHHHHDGSKSQHNFFYPDEYNQANNHHNQQRHINHDYYNYQNHAPQTAGAEEDIKPPPPPPPARSTSREKNPRHPHKPTPAHQRSVSSDRTPQGYYYPQEDPNEGTSTHHSGWRSSHSITTTGGGGGGGGRSGSVGAVPPLNSHTAQPDPRADGIYGTFVQPSPTSPHRPTLTYVPPPTVPPLTSDHAHMENHHHRAEKHNGKQNHHHNNNYNFNNNNNSHNGQMFSYTAQAQNHHHPNQQQYPPSPQQTPSDVSYPPQSPSFAPNSTTSPPILHPVSSPKLPPMNQRNKHRQDNIPPPPSFPAPPPPVQLHDRYMANSGRPRTPSPPPPPPLQDPNSRSRPMSRDQAPQSPRAGHHQVYPPTHPQSADQARSAYTIHQQQQYDQAPLYQAPPIPAQQPVRHHHTHKTPPSHIPPPPPTAPQAPSQQHYQPHRDLNSVPAGVRSPRTASPSRANLAAAVTSPQKQQPSTATADQLAQVKLRNVSESIPETRKQSLETSDTCPSPIAVRLRPTPGKFSNIYSEEQGDTTLPPPPPPPPDDLDELPPPPPPPELLTAGHVNHDLRDPVACVATAAAAPPVTGTVAAASTGTNSSVYNAPPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8Y6</accession>
    <name>A0ABM1A8Y6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transmembrane protein 237</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101858512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transition zone in primary cilia. Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM237 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943096.1">
        <property type="nucleotide sequence ID" value="XM_013087642.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858512"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029409">
        <property type="entry name" value="TMEM237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15383">
        <property type="entry name" value="TMEM237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012943096.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52046" checksum="F735297D45A2F74D" modified="2025-10-08" version="1">MADKDEAQTKRPKPTKKKGLPPISPRANADENDETDKIKPVKRKPRKKASASGANEQPSSPTSDPGNGEVKPVAVRRRKRSPSQNQGGGGGGEGAPAGDTTTTTPRKKKRRPKQTTAEEPDPSQNAESSQPTTDPQGSKTSLISKDGETPRKKAGGKKKKKVKKASAEAVDEDDYGESPWAEDLRTMHDDIITGSQDGEEDGEEGEARGAGTKKVTNMFVAAPILKSQPLEKIFIETSSKFKGQNKSALNEQRLEEAVTTVMPQEVSRMTTSDFALGTNRVFRVVSLFLHGLVAGLALWQTVTVWTLGSFTADDFLEHYYDTAMPLQGCFYFLLVMCTVSVCDRFDIGNPTRRFVLRAVTLQNGAVSILFCLVALVLNTVAIRYEDRMSLYRDYVDLYSGDNVSQAVSGFTTPPNFMKEEEIATFQSVNTARCVFIVLSWFVLSVTPNSDRLGKSLRSGRTGLEREVEMDRVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9L0</accession>
    <name>A0ABM1A9L0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101859889</name>
        <name evidence="4" type="synonym">KYNU</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="RefSeq" id="XP_005108249.1">
        <property type="nucleotide sequence ID" value="XM_005108192.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943441.1">
        <property type="nucleotide sequence ID" value="XM_013087987.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859889"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005108249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943441.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53885" checksum="7CF1C9FC8D52E30C" modified="2025-10-08" version="1">MAKHHPLEDLEKACAESGLDMADEQFARLMDSRDPLRAFRDEFHYPKMSDVLNTDLSLVDPSADCVYFCGNSLGLCPKKTKEYMDVQIDKWAKMGVQGHTNGELPWAWCDECLEEDMTKIVGCNREEISIMNGLTVNLHLLLISFYRPTKDRYKILCESKAFPSDHYAFESQSKLHGFNPEDVMICVEPREGEYTIRTEDILAVIEREGDKIAVVCFAGVQYYTGQLFDIPTITKAGQAKGCYVGWDLAHAAGNVPLYLHDWNVDFACWCSYKYLCASAGGLAGLFIHEKHRSNDFPKLLGWWGHDLSSRFVMDNNMDLIPGARGYRVSNTPGFLCVPLKASLEIFSKTSMEELRKKSLLLTGYLEALIRRSYQRPVGQKVEDDGMSVYIDIFTPHDPQQRGAQLSLAFNVCIEELFKELEKRGVVCDKRLPRVIRISPSPMYCSFLDVHRFMGYLRDALSAAKASLGHLNTQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAC1</accession>
    <name>A0ABM1AAC1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein MG039 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943891.1">
        <property type="nucleotide sequence ID" value="XM_013088437.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851615"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052745">
        <property type="entry name" value="G3P_Oxidase/Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42720:SF1">
        <property type="entry name" value="GLYCEROL 3-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42720">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943891.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="39779" checksum="2859020F827FE21F" modified="2025-10-08" version="1">MLHTGFDAPLYSLEMRCIKECQKSIFQLIDKFSIPLRKCGTVLVAWTEQDKQKIPLIQQKSQQAELGEDISEVTASSLYKLEPALASGALGALHVPGECVVDSWLLGISYLHHAQMQGAKVLTNCRVISVTDGLLHTTRGVVQAKVTMNCAGLYGDLVDKLVDINTFRILPRKGQYCVFDKSASPLFNSIIFPVPSEKSKGVAVFRSVYDNVIAGPTAEEVEGRSRPDFSPATHSMLSTHAKNVIPQLEDLMPIGNFTGVRPATEYKDYQIRSYPDKKWISVSGIRSTGVSASLGIAQYLSEKLTDDMGVLPSTGDNVTLLDIDWKISENGQSVIFDDKYIYQASHPLFVYGHQRMESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAS1</accession>
    <name>A0ABM1AAS1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptotagmin-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944122.1">
        <property type="nucleotide sequence ID" value="XM_013088668.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848387"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08386">
        <property type="entry name" value="C2A_Synaptotagmin-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037732">
        <property type="entry name" value="C2A_Synaptotagmin-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF344">
        <property type="entry name" value="SYNAPTOTAGMIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="91"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="222"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012944122.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40844" checksum="60C9B4072CF15968" modified="2025-10-08" version="1">MVTEHVQPSPGSQTSLNQQLAMREAGNYQAMGITRGASLNSQSRSASEEDRGDSESSVWKNVKSIASMLMEEPEVVEQGAQGPIAEGVDYKLGRLQLGLIYDFQNLTLTLRIIKATDLPAKDVTGTSDPYVKIMLLPDKKHKLLTKVKKKNLNPHWNECFLFEGWPHNKLLEKTLYLQVIDYDRFSRDDPIGETYIPLNMVDLTQSPVTWKYLQPCKDSRGKLGELLLSLCYQPNIGRLTVTVMKAKDLKAKDITGSSDPYVKIWLSYGAARVEKKKTNIKMRTLNPIYNESFIFDIPWEKVREATLEVSVMDFDKLGRNELIGRVILGCRSGPMETRHWNDMVAKPRQQVAQWHLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABA6</accession>
    <name>A0ABM1ABA6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944411.2">
        <property type="nucleotide sequence ID" value="XM_013088957.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013384"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944411.2"/>
        </source>
    </evidence>
    <sequence length="140" mass="15666" checksum="EFF3002F974723D9" modified="2025-10-08" version="1">MNSTLKLNNITQTLNVAIKTTLFDKYTEYPDAYDIERVWYYLVGVAGTVVGAMGVVFNGLSLGVWTSSEMRTNSGLYMIMLAVYDMTFLLLNTTFVSAEYFYFGLTGSSKWFNVYVRPSMPVVDSVMNVALTCSVYTTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABQ3</accession>
    <name>A0ABM1ABQ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101854908</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944656.1">
        <property type="nucleotide sequence ID" value="XM_013089202.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854908"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00250">
        <property type="entry name" value="PLEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="297"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012944656.1"/>
        </source>
    </evidence>
    <sequence length="844" mass="95962" checksum="345C7D0253F12A36" modified="2025-10-08" version="1">MSLETTSSTTKYSVKSVKFVTDRRESETDADTEEDFYSVDGDIDDERKMARSEVQRCMDWLFKQQGEMESATFGQGRLGVLEALAVQQSKVKDIMKFQGDIESVLRAEKVDDFSASELNGHYNSVKALSEKRDSCLEVIGQIAALEDLVQNLSGEFDNRAVHLVNTSDVTKQRGGPTQSNESLARTAQHCITSVRQNWRWVFQVMQCAEVHLRNAAAYQEYFQEVEEAEYWMNTTLSRIHLSFDRSKLNGNRSDAEQILGEIRDVLAAYLQWQTKIDYLFERAKEVVPVPMRITEITDPRPVIALTDFNTSEIDFIEGETLTLLDNSDRKKWKVKNIKGDVGMVPAVILLIPSPSGPALDAAIRLRLQLLSLWTSSVKRLGYQMIAFMLLVFRDWTEEEVGLLQAMAAADKQELLRILHYIESTLMEHWNGYGDFEELQERITRLKMILEEAPEMNGHASPTGSRNGDEFSSSVVVQVKTLEDLLKKYKDFWTFWETFKCVAEMLKQPKFMLVCDKWEQLRFITSAHFVKFWDTQLDLAKEDITKSQASLVMYETPSEEMPVTSEVTIEEEKEETTTDTVMSTLEEEQHTFIIKGVLDPRDEKTQLTLQNAIMLGIVDQTKNEYVNPNTGVAMSMTDAMNEGRVMMEIVSRKKIREEKNSYGLITIKITKESRPYTITGVLDPTSDEKLTVTQAAERNILDLHSSTYRTEHGEKLQIADAIHSGLVLVEYHEGEAHHKPEVVTKTYAVHGVVDTRKKKKVSFSDAVRDGLLDKDTGEYVNNVTGVHVGVHDAIMKGFIKARIVADPSKLEINPENKIVVEKLSSARNKLLRSVKAIKAFQSMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABW9</accession>
    <name>A0ABM1ABW9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101857522</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101857522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944755.1">
        <property type="nucleotide sequence ID" value="XM_013089301.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857522"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012944755.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27610" checksum="9861576D6895C4DE" modified="2025-10-08" version="1">MTPPGIQLPFAPKAVATPYPSSALLAVSSIWVIYGLALNSCCIAVFICAERCLCIALPFKVRDILTPGRSAAILALICTFSLASVSPILSTVELIRTRDPETNTTVVNMFLTRENPPRVQATNATVSTAQTTALLCLLLLTGRLVISLNRHTKWRSLHSQAGVRAADRRVVKVVVIVSVVLMVCYTPGQIYTAVSEFAPEFNYGRRHGYLYRASWALAYFLYTLNSSINLVIYYNMSSRYRATLQALLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACD6</accession>
    <name>A0ABM1ACD6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Golgi apparatus protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101852739</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945019.1">
        <property type="nucleotide sequence ID" value="XM_013089565.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852739"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017873">
        <property type="entry name" value="Cys-rich_GLG1_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51289">
        <property type="entry name" value="GLG1_C_RICH"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046019347" evidence="11">
        <location>
            <begin position="22"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1146"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="256"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="390"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="455"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="650"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="779"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="894"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012945019.1"/>
        </source>
    </evidence>
    <sequence length="1179" mass="134902" checksum="039E720F37F69043" modified="2025-10-08" version="1">MFRTTVAIASCLVVLLCHSDAELTRVKRATLHKADKHDDSDDMVRAPKLPLKSGLAAGALDGTPKLKFGTENQAAPKHAADSGKEKPQIRLEDTVECADDVKRFCSDRMQSNNFMILDCLQDSQKTHDKVSENCHHFLWNYKVNLTKDIRFDTASEEACKAELSRISECNYLPRGQGQVIPCLIEHYDEIETSSCQSYINKMATIIFSDFRFMAPFVSDCNEDIAKYHCGRLEPSEEDDSPHSQGHVVACLNKKDDLQTKCKTALLKVAEIQADDYHLDRPLYYACKADREVLCATTVAGSGQVFKCLYNHMGDKLMSKKCRVKLEERQQLIAEDVKADKSFYESCKKDIKENGCAKKRDIKNHPDELEEDLNRSNILLCLEQAQNNGVQLESQCVKEMFDLRSELMQDYKISPELVSACQDEIDHFCDGLDPDGESVHCLMEAAKEKSKDAKKNFSDKCRVEVAKLLHIANPGEDIRLDPPLQRACGEVVTSACHDRKKGHGDVITCLLDNLDHEDMTDECEEKLLEIQYFAVRDFQLDHNLFKQCKKDAKELCHEQGDFKSMTPDQGPLVFTCLHRLYRSEDPKDKKPSRSCIHEIRRVMRERGARINLNPEVEQHCIKDLSEFCSDNDEHTEEGAEMECLQLHLEDLRSKKCQEAVTKFTSEEMEDLEMDQILMKHCTPMIKRFCQGQLESDAMPNEVLQCLISNKNAKEMDAMCAAGIEHHQIISLKDFKFNHKFREACQDAVQTLCKDKNTKFEVVSCLSEHVRNDTLMEAEHRIDRHCRKQLKAELLERSESIKLDPELNKACEDDVSKFCSGVKAGEAQVIECLKNHKRKLSSSCHKMIFKRQQEEAQFGDYTFLHVCKKMIKTYCRLDASEPELMDCLKEHKDNFDFDEHCRKIVIQREVEESEDYRLDPHLQKACRLDIRKHCSKVLKDVKNGEEMDGRVINCLKKKFTLKDKVLTKDCEHEVRSRIKEAAIDINLNPVVMKMCKEDIKKSCSDKVANVRHMSVDSDDGYGTYETFGHGAVIECLKKNFHTLRNNDCKTEIAYMIAESRVDVHIDPLLNSACQKELVVLCSSVSQGQGRQMSCLLAHLESDPQGLGRNCREMIRRRKELWEYAAQVAPPESFSEIYEEISASPARNYLLAILFSVVGIVFIMGLTCGRVTKRVRAELKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE43</accession>
    <name>A0ABM1AE43_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 92 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106013809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945948.1">
        <property type="nucleotide sequence ID" value="XM_013090494.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013809"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012945948.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="54275" checksum="1D41F040F1E6585E" modified="2025-10-08" version="1">VVDEHKLSESAALATAHVTTSSDEEDHPHHTLQNNSNDGGVVATTTTTTESGGGNKERKDVRSAVTLRCPVLDRKSEIVKVKEAAASDVKKFVVDISSARTGSDAGADDEEEEESDTTKREIDSSVAFTSSSSPPATSAAAAARSAGGDVSGGCHANETSDGVAARESAAIRTGDGTATITTTTTTGQGPRREEVEKKAGRLLVVGAADVCREDNCSHGKEEEGEEEEEDGKGEAPAKAKKEDGEEKTNGDKQPEGGQLKNDRSNEEDRETKDGCGAEEEYVLQCIYCPSTYGRATLLRDHMRADHPEKPVRYQCPRCEQTFLLKSHLDKHLALHSPTSQACKVCQKTFANVYRLQRHMISHSESTDLRKFKCPECGKAFKFKHHLKEHIRIHSGEKPFQCPTCSKRFSHSGSYSSHMTSKKCWVMGQQNKAAQQAQGRRPPVAEREESGGRGANPGAAFPGQEGAAAAAAAGRFLFRPLGQVFSQPLASPPPGMLCVPSAFPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEQ8</accession>
    <name>A0ABM1AEQ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101849988</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946270.1">
        <property type="nucleotide sequence ID" value="XM_013090816.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849988"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KY-like immunoglobulin-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946270.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23301" checksum="AF3D4CB9E37952D3" modified="2025-10-08" version="1">MAAGNVQLPKITEGFLGPQAKFDVYGLSTVSHSDPVVYMQEDQPEVEIIMGTQPGTRVTIKLISYERKKECTEYVLIRALGPNYLFLIRPPLPGFYKFQIYALPPDEAGPQMLGVYNYLVYCPGSFGDNAFPKQYPPWKSGCYLHSSFQLLRPYVKVDQEWNPLQQTEPGVFEGLVDFSQGYASGSKAKVNVKFAGNNYQTLLEYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF39</accession>
    <name>A0ABM1AF39_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein 61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946465.1">
        <property type="nucleotide sequence ID" value="XM_013091011.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857003"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012946465.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33454" checksum="28AFA731F8380628" modified="2025-10-08" version="1">MNAQALVFKQEQAHDDSIWSCAFGRNERDPSMSETVVTGSIDDYVKVWKWQEDKLELRHTLEGHQLGVVSVDINADGSLAASSSLDSHVRVWDLDSGKMAKSIDAGPVDAWAIAFSPDSRFLASGSHTGRINLFGVDSGRKESSMDTRGKFTLSLAYSPDGKYIASGALDGIVNVFDITTGKLIHTLEGHAMPIRSLCFSPDSQLLITASDDCQIKIYDVQHANLAGTLSGHGSWVLSVDFCADNTHFVSGSSDKTVKIWNAGTRQCIHTFYDHMDQVWSVKYNPSGSKIVSVSDDKNINVYDCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFB3</accession>
    <name>A0ABM1AFB3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106014074</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106014074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946567.1">
        <property type="nucleotide sequence ID" value="XM_013091113.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014074"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946567.1"/>
        </source>
    </evidence>
    <sequence length="759" mass="84914" checksum="2C71B09285C95B04" modified="2025-10-08" version="1">MFSHISKRGCRTDGSESPTSALSHEDVVAPDSIFFTAPPSSSPSSSPSSSSSSPSSTKANVSLAEEHMQTLLDGKVPPFCTASGHPQRDGLPNEELRRGSQLPGLLSCELGHEKQTILVSGGMPGTSEKETKDCSLSSPSVTGRSAGVGSEELTQASHNGAGRRGLLDLPEEILSVILVRLPTETLTSCVHAHPSLARVVTDRHFLDTHMRYTLGFAHSEKDVNCSWLPQSFPPLTELTHFTFQDLRPQNHRNTSPLPRDCHLLLLSVFKHCRQMWLSQALTSIFPNISDNFRNSVPPEDHLNDDFSFDTSGLYPKTSWELPVFLMQPLTRIALCFPEFVQLTLRPTAAFMNLSSNIHCWAAGIWNDGVQENLRDNVHPRYSFQIIWDLNEFEKHELSSVVFFFGDGRWLVWAGEVTRFPGCVWRETHNIVVLDPCCSMSVLESACSGLFQSLSQRVSRECLTNNKKSREKWYPGVCDFFQNYLRNTRVLSLRESMRNLAGTMQYFILTPARDRLLLGISAHDPITWDCEDEGAMDYSSCSTCEDVAGSNFFICNSTRSKMLDVDSTLMEAEDTNSNFTTNMCFRLSHPTNLSWSTCEEMVDQDSNFTTPIGATSSNNLLFLLESLYLPKYAVGTFQDIHSCLKQALTHAFHSDLFHFLTDYKCHNILCAGCQKAWFPSATRTAECMSRFSAVEFSHSEHTLDVVPFIPFEMWPIHLITQATLEVKALTDMLRPVTLTSSQSHLVQSRDKDFLKAAGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFB7</accession>
    <name>A0ABM1AFB7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">cGMP-inhibited 3',5'-cyclic phosphodiesterase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106014078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946571.1">
        <property type="nucleotide sequence ID" value="XM_013091117.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014078"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946571.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="40598" checksum="403E4CC125947CB4" modified="2025-10-08" version="1">MALARNSVSRRGSKNDAEKEEDEAENNGYIQVFVKPLEQGSYGYLLKLLGVSKANFSAQQLGVCYGATAIASAVLLYQLLRCDVGILFQRLCSLLVPMFSILCAFYWLSLYFRRTWSNTSVYLLFCSCYVGEFFAQIFLRDWGEGSTSQPAEGGGAGEGGTVASSIVLSNHTTQPLVIVCVLLSISIASVFSSLETSHSAGVILLVSFTRFLACSALQDIPFGLRPFVAYTCGFAGNVVAKYMETVLKPPIQNFTTPDGKIPVIKRRRSSSSSAHAFSAHRSARRTSLPALIQKSQSSSAGYESAIIGEAHGLITDMLADSNLPPHIISGLRAVSNLLKPPDAHGCFHKPRVSPLVSLTENTSYGSDSEESPYTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG49</accession>
    <name>A0ABM1AG49_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106014244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012946988.1">
        <property type="nucleotide sequence ID" value="XM_013091534.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014244"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012946988.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33150" checksum="23AD2807BB1CFB5A" modified="2025-10-08" version="1">MRALLFVSEIAQGMEYLHKMNITHSQLRTAACHVDNKWQVKVADWEVTSLFDNALLMSTAHEDADWSSSLFWTAPEVLRYRFESTKSSDAYSFAIVLQEIFIREHPYHELQGRCWEMDPMARPSFTNVVLSLKSASPSNRGVLHCLMDSMEALAVSLETKLTHKSRDLVAREKQLEVTLLSTNPPVVAEQLARGDKVMSEAIKSATVMCTKIFNFNDLIGETYTYDKGIDLLNYLVEMLDSFTERQQCFKVNELPYGISVISGLNENENDHVAAVCAVSLQWHGFLRQGKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR10</accession>
    <name>A0ABM1VR10_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 23 24 25" type="primary">LOC101860398</name>
    </gene>
    <organism evidence="21 25">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23 24" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:78543"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58591"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:78544"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-disulfanyl-L-cysteine + tRNA(Cys) + ATP = (S)-disulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:78651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:19120"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:229465"/>
            <dbReference type="ChEBI" id="CHEBI:229521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:78652"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:78627"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58591"/>
            <dbReference type="ChEBI" id="CHEBI:229465"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:78628"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>S-sulfanyl-L-cysteine + tRNA(Cys) + ATP = (S)-sulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:78647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:19119"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58591"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:229520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:78648"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tRNA(Cys) + L-cysteine + ATP = L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:17775"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005095348.1">
        <property type="nucleotide sequence ID" value="XM_005095291.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095349.1">
        <property type="nucleotide sequence ID" value="XM_005095292.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936254.1">
        <property type="nucleotide sequence ID" value="XM_013080800.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824852.1">
        <property type="nucleotide sequence ID" value="XM_035968959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860398"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF27">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 22 23" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="20">
        <location>
            <begin position="436"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="598"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_005095348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_005095349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_012936254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035824852.1"/>
        </source>
    </evidence>
    <sequence length="636" mass="72185" checksum="FE2780992048A1CB" modified="2025-10-08" version="1">MSFKICHFCGKMRLTSRVSQWTTPTRHHSGWSRWISSKVEIISPLSTEPSVFYPSLSFWLTGRSSVRGIYSLSTKWNQPTGYDTGIKVYHPVVKDKVPLILGQEKLAQWYACGPTVYDSAHIGHASSYIRQDIIRRIMGSVFDIDTTLVLGITDVDDKIINRSIETGQDINQMSRFYEAEFFSDMANLNVSPPSVVTRVTDHIPVIIDFINGIQQRGLAYKAQDGSVYFDVKEYGRYGVFVSHPDKDKDESSHKRSSQDFALWKACKPGEPHWESPWGRGRPGWHIECSAMASGIFGCNFDLHSGGEDLIFPHHENELAQSCAFHGNQQWVNYWLHTGHLFVSGQNEKMSKSLKNVITLSELLEEYTPNQFRMLCLLSNYRKKIEFGEERMKKAMSTMNAFNSLIKRCDSYVKGQIDCGDIPEAELFEKLHTTRRAVEKAFADDFNTPQALANLMRLVKFMNQLLGEEADREKESSVRSNAPVAAVGVYVKRLLKQLGLDIGRRKAEEETETHLQFYKAVETVVNSRSNIRDFAKDKKFMIEKAEEAGIPGDKAKALMKTLYKPLWEASDKIRKDILSNANVQINDAVEGSTWSIVDSKRSSQKLKEQQEGQKITIRGSEDEDSDGGRNSPHSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VU89</accession>
    <name>A0ABM1VU89_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vegetative cell wall protein gp1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825981.1">
        <property type="nucleotide sequence ID" value="XM_035970088.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477780"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825981.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23462" checksum="7B57420D035EE18B" modified="2025-10-08" version="1">MAEPSLGEADSDSDGSQEDFKCIVENIRRDLQDAYSPSPAPSLSHAFSPSPAPFLSHTYSPSPAPSLSHAYSPNRTYSPNPTFSPNPIESPNPAFPTKSTSLGGLNPSSFPVCGRSCAPQGEVNRKKLTLSETYPGENERLSPTETSCKKPSMRRQSQGGSDAKSAGSAGGGFRRVWINWECRTPFVFTRLTSQSSEVIDEGKSYLLFSCRFQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVI4</accession>
    <name>A0ABM1VVI4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ral GTPase-activating protein subunit alpha-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101861291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826426.1">
        <property type="nucleotide sequence ID" value="XM_035970533.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861291"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="1764"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="840"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="913"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1413"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2022"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="757"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="935"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1413"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1434"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2027"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2060"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2083"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2120"/>
            <end position="2148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035826426.1"/>
        </source>
    </evidence>
    <sequence length="2190" mass="241958" checksum="8BF7D16C00668BEA" modified="2025-10-08" version="1">MSATLALFRKTAGHGDIKKSAQKVADTKKDTVTRLKHLRLVLDNYEIQDAKKFFLENYSHIYYIFYDNFGTVEADLKQRANKAHREELEAILFIFEKILFLLPEIVHKRWMFHSIGRIIKKLIHPGNSLQLRRQGVRLFLVWYQCLQENASEECHRIFLSLVPGLGDGPDLMTLMTDNTASADNIGGIIAAGEITAILPSQSEKIPENVTKYFLDNLLNYMVSEVIKVEWMNSEMREQSFHFLFTKFKAKYLHWLLPDFVYRDIYDPIQELPTARSKEDMRKKDEPSAVSECRDSFIFWLANFTVTSHKPDPELHKGLSCSLLTEPSSHTGESRDSGPGRGEEEEEGEDSKLALPGSKGSSLSAEAGQNEKEAACGDWHSVSEYDIVRAVLYSTRENVNIVHECFRQALLQSFKHTAAIRKVISVYKEWFQREEDRPVFMLEPMASERDLSGGVDGACEESPLDGLRPGSLEFHHSSLSDIVEEDRNFMDDSPSTSALSLHHLTAPTELEDGTGRPSYLRNRSYLGAVQDLADQGEDKAKDVRAGFQRVMQVFINNAANIFLLDADDDTYLQDQVELCKRVMNIYRHVVMNVEMNQLTWELMLKVLLKITSGVLKKNPPEERYRTLGGRLAQPILQTLIVTWTKANLNVLVTASLWDEFLAVLSSLTSWKELIHEWSKTMETLTRVLARQVYGLDLNDLPLERLSEQKEKRRRGRESTKGKPSSSTTTSTSAKAVPRLDKSFSRGLSGSDGHPINPLRSSTNSAPSPETSASFDRGTKYKSDGAGGKVRPDLSKQKSLSGEPSPSHSRCPSTSTECLVRSSSEGNIAADPHELLEKLRASNSPCAPDDGDEQTETDSDLGKSAANDPGGVVRSSGASAAVEDVEVAEITTTCTAELSSMMGPHSVVRQSSLEEGFDRSDHDMTRGTGSRTSSACSMHSARSKSGSRSPSPPLLNSTDNHKDSPTPDRDSLHIDITGPEDANSNRGLEVSVDSLDELKSIMAGGKVLGWTPDVAVVLWQRMLGSLGDVNKMEDPDIHFSVFDELAELMDTLCRMSDNLGVTQDNMSSPPPPELIPPLHIFSSWLFQCLTLSNKFKHGKLMAYQLICQMMLRRHEVMPSQQLLSHFYLVLHTGLVSADQDIVNVLVRDCGPKFFSLCLPGCLLLTLDFIKAAGSIISAVDYKEPPRAEAVTVLGSLLYLPHHVPEIPALEPEATGTTRSVQGNQLKDLVLDLLLKAGKREPAGLARCVAVSSVAIFLYGELSHGTMHPKMKEAINVLLGALMSVNKKVAKVASDMLLLLCDHVDKLLDYHPQMPKKITEAVASTISALIPSHGASNSDEEKRLIVSMMFCMVEWCLKMPMPLLMETTDTDKSCIYKVFRVLHSAVTGHSSSSLTRVSKSLSDFLLDTDFTNIWDTQSGSLTPQPGPSSASQRPFSADATLADAATDQTRPSLASQHSETGRKPETDIVKLAARALMSHLVHHMSHFPMGSGAARLHTLVQEHHDLPDYLEDDLRPEIFQAPNVQFFVLNHRCLISFIELPAVDAPGGGVTAGLMTARTVCRIIVRDLCGKYCWENSVLYSPPWCTKGSSRHNAQTLLGLATGAELEPLLIQEASDTRAEQDTLPTPTRGLFPQHGDTPTGADNLNNMLAYIGDTSPECLLRPGMPLNIAARVPEDLTEQAESAVNRMVGEQTEAEEEHRSTHRMDIRRDKDQEHMVAPPEMPAESQDPVSPFQMCRLLLDQMGLLSWEKRCHFDLLKKSDKVLRELKNLDVQKCRETHKIAVIYIAAGQEDKNSILSNNSGSRAFEDFVAGLGWEVELESHQGFMGGLQQNRTTGNTAPYWANSTCEVVFHVSTRIPSTGTDWHIKMRHLGNDEVHIVWSEHSRDYRRGIIPTEFGDIIIIIYPLPSGLFRIQINRKPEVPFFGPLFDGAIVDQQVLSGLVRATAVNASRLKRSLMPFYHAFYEERAKCLETIIQQHTEHTMFEEFAENVFAPVLPANAAIVDVTLPSESSSSSLNELSQGMAGDLTVPQMSPNSGRQRASDSALLDVQYPPTVSSETRLQRTARRWSIKSRRASGSKVPPSPGSPTSCSPSPTVSALSAATAFLLPPPDSPKSKNGGGGRNSVSGVSGVVVSGGLLTTNSSSNNNNNNNVGVDMVESPRAKSGKSKLDTNSPKTKHGKSRSESPKAKSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWW5</accession>
    <name>A0ABM1VWW5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein LOC101860670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826907.1">
        <property type="nucleotide sequence ID" value="XM_035971014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860670"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826907.1"/>
        </source>
    </evidence>
    <sequence length="817" mass="92924" checksum="5ACD0D6C5FF7023E" modified="2025-10-08" version="1">MEAKLDGRKVPKMSTSHKARLRPISRAETMVNLAISKMRSQHTEGEAEKSAKTTDFDPFDVDPDNPFDIDPEYRFEVDLEDPFEDDPSYVPGNDSSSSSEDSELKDPIQTTLKRGPIVNTEKTKPKRPCYYCGEEQSQLVRHLKRKHKTEDAVVAAQLLPKAEQLRAFEKIRKEGIFRVNLSMMEKGQSLIRERRQGSSNNADVRMCNGCHGFFDRKQIYRHXKRCVDISGTSCGSVNFSTSWKSAESLGVTEEFKSVLDSFRNDEAGRLCQSDSFIILLGKKLWAKSIKKEKHVVMSEMRVLANLVLRMRIVSLNENLCAHNVVEREYFDTLCDSIRDLTTGENGEVKPGLKLKIGFLLKKIIKIAKGTYIQAGEIEKSVEIDRFSAVLDLNWDYIFYTAQVMCEQRRNTLRKPQAMPSEEDISKLRVFILNEMHKLSGDEFKNWDLHDFVKMRNLIVSRLTMFNARRGGEPARLTLQEWKEAANDSWVDPQLVQTVKDPLEKALFKQFKLAYQAGKGSKKLVPILIPIDTVKPIMKLVEQRKEVEVSEANPFLFANTGTSLDHAVGWQCIKAVIKIMGPELEKPELLIADKFRHRMSTLFAVLDLPENERATFYRHMGHSEAINKHVYQCPLSIGEVVNVGGFLKAVDEPSTTRSKLPVLATATANPTTVTEASSEFQSTENNGQGHINESETELLTAQQPTPEELEEFPDLSDESRKKNEAIGATKGRRYCKWSIENTRLVKEFFRETIQDTSSVGFKGSLPGKSDIMAFLDKHPIFRESEESKFSLKEQIALVKTKIFNERNKARSSFKNLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYY1</accession>
    <name>A0ABM1VYY1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kinesin-like protein KIF15 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101846449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827624.1">
        <property type="nucleotide sequence ID" value="XM_035971731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846449"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044986">
        <property type="entry name" value="KIF15/KIN-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="15"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1315"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="574"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="693"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1325"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035827624.1"/>
        </source>
    </evidence>
    <sequence length="1350" mass="154324" checksum="ACFB3A61C32AD5E8" modified="2025-10-08" version="1">MDTLSSSSNSSEGDSIKIFLRVRPPDPSISENDFAPRVLDVNTADNAVILRTKPEPKVFTYDNVADADITQEAVFSIVGKKIIESCIAGYNGTIFAYGQTGSGKTFTMLGPSENSDSFKHELRGVIPRSFEYLFNLIAHQAELHGTKKQFLCRCSFLEIYQEQIFDLLDPASQGLHLRENMNKGVFVDGLIEQVICNPGDAYQVLIMGWLNRRVAATSMNRESSRSHAVFTVTIESKEDDCGVQNIRTSQLNLVDLAGSERQKDTNTGGTRLKEAGSINKSLSVLGNVIMSLVDLSHGRKRHIPYRDSKLTFLLRDSLGGNTKTRMIACVHPDSKCFGETLSTLNFARSAKLIKNKAVVNEDFHGSNLKLQNEIRRLKELLESQQNASPPVENLLTLPNEAAMNSDSVWKKNFIEAMHFREISESEKTALQDVVNHLQELCNKKDKYIQSTKMIIKFRENHIQSLQQAAQGYTELEKDTVVKSLRDEIKVLRQQLENNPMLAKYAGENKHLRSELKRLRSQESVADEFGDSFRISQLEKIFKELKLLKEMKGGNTAAASVRSSPMKDGVPAATLEKHRKEIKEHQEQIEQLKQQVLEVTKKAENRQMEMEIELVSCRKMITELERVLEAHQLKARIECNALKDLHCQTLKVMTTPKMNGKCDSPGTPTVGEAANTEQGITETALPQDVAEGAHDALMEEIQTLQVENGKLKKLVDDHEAEKLRMKQQVEKLELYNEQLNGVLEKERTENTSRRNDYTTAVNTLKEEIDTVKNDLKLLNDENTDIHLVLKSADKQLKEEKESRKNLQATYTQEIQVLETRFARANIDLETTTRDYEEALKELGSIKEELETNRLTVSFLENHSQELEALRNLEIKKREKLEMDYNALQSSGSMQSYQEYKEQAETNLKLKQAELEAVRAEQEQVIAQQARAMADNKEAIANLMSNLHELKSKLNSQEEVNGTLSMENENYALELKDLKRDQELTSKELACVQQELKDIKEKYKHQLMQKVFEIDNLQQDQESANSHLLKQEEIISSLQGQAKTKDLLCKDLQDTVDTYKKKLSDAEQAMQEVVNRYEKRLQEASASDKDTDSIKKLMQDKNVELESLRVNYKKLNSALRDYEQARKEKNEENELLKAQVLELEVCNQSLLTGKQEIEELQMKMNALNVNNKELIKSMEASLKGKEEELQKERSSLRKAELSLGNVQEECKTLEKKLETSEMERGHFRQEVNRLQTRLEAHHQEKTELHSQIESLAEEKAKLATEYQVEKERNQQLMEESSRLIGHNNHQQKIKLMEKKNMEYNELHKKYERLLLETSKMNLKTPGKSANPSDWRTPTSQSPGMRDITNTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZ92</accession>
    <name>A0ABM1VZ92_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate-rich protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827735.1">
        <property type="nucleotide sequence ID" value="XM_035971842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855743"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029281">
        <property type="entry name" value="FAM194_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093:SF18">
        <property type="entry name" value="GLUTAMATE RICH 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093">
        <property type="entry name" value="SIMILAR TO CHROMOSOME 3 OPEN READING FRAME 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14977">
        <property type="entry name" value="FAM194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM194 C-terminal" evidence="2">
        <location>
            <begin position="678"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827735.1"/>
        </source>
    </evidence>
    <sequence length="930" mass="102881" checksum="12796C6A9492E434" modified="2025-10-08" version="1">MDSLERKRKETRTKLHSRAFKFLGESECLDREDSMDPVRPKRGSRGSGSSRSERSNSRASSRAASQKSDKRKSKSKVNSPVEPEKEVTFDDDADAVPEQGYAIETTDSDEELTDLDADKLQDDVQKEEDIHQLDDEHLEPYIDEEAVKAELGDPEPSAVDASQNDAQEKDETLESKDPKTTEEDEEEPEAAVAKNKRSRRLKVTTEKRTAFDGREVVFVTEFTQTDWKWKDNVEKSGRGRVLTATNENESQSQSQSVSSLKSILVKPESRQTVSQARTEEESTFDDRTGTDLTPFSLQPNDEFGIPMLDMSSDSDSSEDDSPKKPRVHKHHLPSIGPPQILKYIRESDRMEKETDRTSSSMDDEYRQIDSTDYVLDQDGNMAGMFSGPCEFCGVDIKPFPSLEQQLSQPPESLYCCEDYREFVEFAMTTANRLEEDVAKKNEKISIKVHGHHGSKQARKMAKEQAVQRMRERELQRRQQEASGLQAAFYQSAAAGTGTQGGAASRGPKSQPGGAMMFKDMAYDPEEEVADDVPDGTRKKSKRKGGGEEGGGGEGGGGGKGEKSSGGGGKGGGGGGVKGNVGAGGTQQGQLLTSSQGQHLTSAQGQAGASFSSFGGFSAEVARQMKTINYQLSSQKCLEEGWTLRAPSPLDLDDLDCEVFIPEPLHPAMIASGKLHERKLIEKFYPDGSKFLTMFPDGTGNVFYPSGRVAILIISISLGQFTYIVQDDCSEPELLAVFEPNGYGCCYFANGKVRLNYDQHGGMELDYGGGRKRIWSWRDQETHVHAPPFQPIVFGMNRYIGVRFMAQESIALTLTGRKRSCRFNVGSKLKLVAPENIVPKGIDENQLFIDERKVKVDHILNKVTTLLKFPKSPKVDRILPPLSVASRQQKVDRMKQEYAATLAIPPTVPGRKQKKIVKQSRLSPLPTVSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZP0</accession>
    <name>A0ABM1VZP0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">N-acetylgalactosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC101854437</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942625.2">
        <property type="nucleotide sequence ID" value="XM_013087171.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827883.1">
        <property type="nucleotide sequence ID" value="XM_035971990.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854437"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="6">
        <location>
            <begin position="110"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="7">
        <location>
            <begin position="357"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012942625.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035827883.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="50255" checksum="BC94C5783F0DF22C" modified="2025-10-08" version="1">MAEGPPVLPVPEMKKERYDEIKKKFVEKFGEDPAFFARAPGRVNLIGEHIDYCGYSVLPMAVEQDIVMAVKPDSSGKLTLVNTDGTFEEYEGNVMNIHITKDVPHWYKYVLCGVLGIKEQFCSLVTQGFKAMVDGTVPKSAGLSSSSALVCCSALAMLRANQWPMSKEQIAETCAKCEHYIGTEGGGMDQAISITARLGKAKLIEFNPLRTTDVQLPGNASFVVSNSLAEMNKAATPHFNIRVVECRLAAQVLAQSQGSVKWREIKRLGELQEKLGLSLEDMLSLVATKLHTEPYSKEEVCSILGTTPEELAETSLSSNTLHVESFRLYQRATHVYSEAKRVLRFKVVCDEQPEDALEQLGQLMNESHASCRDMYECSHPELDKVVDVCRQAGAVGSRMTGAGWGGCAVSLVRCDAVKPMLAQVKDNYYKLEPKKMERVKEALFATTPGDGAAFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZS7</accession>
    <name>A0ABM1VZS7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118478432</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118478432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827920.1">
        <property type="nucleotide sequence ID" value="XM_035972027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478432"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035827920.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27183" checksum="84CDF01DB7006CCD" modified="2025-10-08" version="1">MKAFDDQRPSMMAVSGGATTPLFSDLMCSRLKMLCSRPDLYNPTSPFSVHHLPPPPPPPPSKTIEDGTECVVGSAGPTSIHPLRQPDFSGGCLDLDTRTFSGADFTTFTAPRRNANVNHINFLPMWDSTDVSDTLRQRLNSLQSMSTFSYLGHQGAKSDAAIFSDCPRVVASYPDPLAVRCKLGRQDIDLAPVSPKLQHWDVAGKAGEYNKESKPGPYTDVIGFPGARADGTRQVLLGKIDGKKKRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1C4</accession>
    <name>A0ABM1W1C4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828467.1">
        <property type="nucleotide sequence ID" value="XM_035972574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847150"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="828"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="861"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="894"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828467.1"/>
        </source>
    </evidence>
    <sequence length="1320" mass="142733" checksum="825074447C0596E6" modified="2025-10-08" version="1">MSECGFSFRQAIVQEDIDSLEAYVKSHAGCVNGVTDRSGRTPLVQAILCASFKCVTTLIDCGADVNKPDARRCLPVLAAVLVQKPHILRALIDAGADVETPQETPLLLSLGTSVTGFSPSLKVGLSSFDSTDILGITPLMLAAKCGHLENVKILIQAVSDINKKSKDGNTALMHACMSGRNEVVQLLIDAGAGVNHINVWNRTALMMAAQAGRRELVMTLIQAGACVNMASDFMGETALTLMAKNSLAVAQSLLAHGADVYHRNLLGETVLHKLAGSADVDLIKLLLDNGADVNAVSQNGNTPLFSTIQEKSIEVAKVLLRAGADVNVCVDDSGVSTLHRVCLSCPPECVRLLVQFGASINSVDKKGNTPLISAASETGQTDTVKVLLELGADVRMENSAGHTALMVASHHMDLEATALALLRAGSDPNHSSKCEETALHIAVCWSSPALVSEMIAAGAVVTSELHEAVNFGKFDKVQAMISAGASPSLASLSRIMRSPLQLSFPVSPLFVALMRQDMDIVNLFLSLHFFHNFDVTVLGGVQELREYLRSRGKSHSLNCVKSLSSHPWSLWALSFVCVSDHVDGGRHREQRLAATGLPCSLQRKLLFRTSDFRASHICFVEGKTKEVFDMSQLLQAIEGEIKVLCDNRVERERERERNTHTSPTIINQELCRRQRLGSATENKTMDMFRAISEGDTAVLTSLLRDLDLTAGPSSGAGEVMMALCHAARKGQVACLRLLLGTGVDWSRRRESGYDDPILVAVTSGQPEALEVLLSAGDDLDLNQGRDEDGRMVFTSPLVRALKRDSGPHYRCAELLLDHGASTHIATYQGLTPLMVASTVGRTAMLERLLEAGDYVDRADELGNRALALAAKNGKAEAVRCLLAHGARVDARNREGMTALMLATQAGHFESVRILLEEGNADVHALSWGNNSSLMFLPADGCDIANLLCECSGRRLWINKRNHDGETALMRVLKRHRMEVSEGLLGCLRKLGADVNRADRMGNTPLLRAISSQTDKVVCWLLDAGAKVNVSGSGGDTPLLLAANFDRPEVIRMLTKFEVKLDVMDKQGNSPLMLALARHASLKTIDLLIDLESDVNLQNRDQRTALMIACSAACTTPGDDSRVLKLLRAGSNPCLSDETGRTALSLAIFRKNVLACHALLEFAATSCPVSSPELHQAVVNGLSSVVEKMLVHSGVLPSLQLLSSRDGPQVFRNCPLSLFFTALLVGDLRVAQLFASVDFFVQFDSIESSSELKLSLLNRLEDEGKEQILGVARSVYCQPWSLWGLSFLKVSTCVGFESDRQLKLSRTGLPTSLQRKLMFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W477</accession>
    <name>A0ABM1W477_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Focal adhesion kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829470.1">
        <property type="nucleotide sequence ID" value="XM_035973577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847553"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829470.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41178" checksum="6A6309EE5CB24E41" modified="2025-10-08" version="1">MELAKHGEMRAYLQNNEPRLDLVMLILYAYQLSTALSYLESKKFVHRDIAARNVLVSAHDCVKLGDFGLSRWVEEQSYYKASKGKLPIKWMAPESINFRRFTTASDVWMFGVCIWEILMYGVKPFQGVKNNDVIGKIEAGERLPLPPGCPPSLYNLMCSCWQYEPSKRLSFADLKTWLYEILEEERYRQEEEMHRDNRRVQALPWGPQLSSNGSDEEPPPPPKPARPQFSPTGSTPNLSAVGAGGNVSLNASVASLPHQWASSSNLPVGHSTPAAGPSPNTDQLKAHASQHAHMHHQHHQQLLLQQQQQQQQQHAQEQQQGHLPAAPGAHVEYQLQNYFPASGYMQLCAQRSEVRWRNGTTPAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W582</accession>
    <name>A0ABM1W582_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Histone-lysine N-methyltransferase, H3 lysine-36 specific-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101856636</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035829825.1">
        <property type="nucleotide sequence ID" value="XM_035973932.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856636"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21991">
        <property type="entry name" value="HMG-box_NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15566">
        <property type="entry name" value="PHD3_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20144">
        <property type="entry name" value="PWWP_NSD_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05838">
        <property type="entry name" value="PWWP_NSD_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047443">
        <property type="entry name" value="HMG-box_NSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055197">
        <property type="entry name" value="PHDvar_NSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22908">
        <property type="entry name" value="PHD_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23004">
        <property type="entry name" value="PHDvar_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="13">
        <location>
            <begin position="62"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="13">
        <location>
            <begin position="588"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035829825.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="73078" checksum="C2AF788A8A691D88" modified="2025-10-08" version="1">MMSSDKESKGGNTSDDNTPTKRHSPRCVPVHPKEFPAKAQLEKLFVENTVAMEPDVPRRWLEGDMLWGKIKGYPYWPCMVSKDPFSKLSAKPTGPMKAFWSYHVQFFGADAERSWVNEASVLVFEGREKFLEIVQFGLESPSKNCKNPDCFRISTAWFPMWNMAVAEAEAAFKLSRVERVEQYAFKYIVIQGDKERPVDKLLKAIWRRCGMKHTDNDQNISEGAGSDSDSDGDEFGYRERKQRAVYDSDDFYSSDEESSCEAKRWRVPVIITVREGQFDVFLSTHTRHIQSAHAAWSSADVKEHLRQQWCLMSRLQRSRYVSRHQKPVRREVRRYRQQSVEILEDTGVLDPLTLDLCVLKLSMTSVLSATDLPICVVCAGKDDVLECEGLCGVFLHARCSRSGDGSVRCCYCDSDSPVCFCCQASDVNLKQCDDQSCVKWYHEECVQTLRHTRARQGSFACPRHLCHSCEVSCSEKNQVSIDLCQCVHCPAAYHATDHCVPAGSRLLTKRLLICPRHFKPSKKQSQHSSVHVKKCLSCGQGGELLSCCECPAAYHVDCVSAVGGTVTCSLDCRHWQCVQCVTGLQILYGEIVWAKLGNYRWWACEVCHPGYVPQRVRKKTPVVGEFPVRFFGSQDFAWLHRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA10</accession>
    <name>A0ABM0JA10_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA polymerase II elongation factor ELL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101858529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELL/occludin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005088885.1">
        <property type="nucleotide sequence ID" value="XM_005088828.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858529"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCEL" evidence="8">
        <location>
            <begin position="437"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005088885.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="61306" checksum="0789B27DA2124D68" modified="2025-10-08" version="1">MATLLEGQEYGLASNELLGSNKTVIHFKLTDSCLKTLEELSKRGQGVLPSIQFQGNQGVIRIPSHVASAGRQPERTYQVSLSALPGDLNGSFDCIQQTSRHGTSHLHSLGSMHHRVAVHATDDVYDRTRAKMTMAEEENKKVCTKEIKPSGRHISKRVKKVLSPGSLKIPPATKPSIISKPAPSSVLSAAGRHGSGLASSSALSLSSSSSNSTSVMSQRMSNSPLSLSSSQAQSKSLSSSKLSSASNSSRVLTSSTTKQSSGAINMPYRDRVIHLLALKSYKKPELILKLQKDGIREKDKNSLGSVLQQVATLNKDNSYTLARAAWVDVRQDWPFFTDQDRALLKKNLQESRTTPTSPAVSPASSNPESPGSSQKRVIEEPEEVSANKKKRIAHGERRQNEERPVSVVKPTLNQQSSPTANRENVEGTVEDSSCDKPEFISKYLAIKNTEQRQQYKHEFNREYSEYHQLHREVDSVARKFLNLRSQIDQTEEGSPDFEVLKKQVLEEYEAQKSDPKFMAKKQRMEYLHQKLGHIKRLIHDYDHRGQVLTKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBF0</accession>
    <name>A0ABM0JBF0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenosine receptor A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005089798.1">
        <property type="nucleotide sequence ID" value="XM_005089741.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859290"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089798.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37292" checksum="845F09220B32A3DB" modified="2025-10-08" version="1">MTSSSLAKFVPLISNEAWAIIQVVNFVLICGLGSLTGLVTNVINIVVFAKQGFHDSVNVSLMGLAVSDLGSLVTTFWLSICFNPLFINAGLPINVMEVMNATGGRPHICFARVTSFITAFITFERCLCISLPLKVKMIITPRRTKIIIIFIFILMFSYPPFYVGNRLAWVFDSSRNATILKLEYNEEITIVEPIAFFLYGVTFSTFSFVFVICCTIVLVVKLNTKTKWRQATAAKGASAPEGVGVKDKKVVKMVTFISSIFIVCFGPSSFLFAIMALEPRFRFNGAYTNVYMVVWSASFILETVNSSVNMFVYLTMSSKYRAVFMKTFLGREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBW4</accession>
    <name>A0ABM0JBW4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101847235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090113.1">
        <property type="nucleotide sequence ID" value="XM_005090056.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847235"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047120340" description="Glucosidase 2 subunit beta" evidence="8">
        <location>
            <begin position="24"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="457"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="123"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005090113.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="64523" checksum="86E3B7EEC7F802E7" modified="2025-10-08" version="1">MELPKGLLTSVFVFLSLLSFSFAVGRPRGVSLEKASFYEGGTEFKCLSNGRIIPMDHVNDDYCDCEDGSDEPGTSACSNGLFYCENKPYKGSYIMSSRVNDGICDCCDGSDEYDGTISCENTCEKLFAEIRAQQEAFREKQEQGYKVKLEYIQKGKRAKDEKVARLSELERTKETLVQVRNGAEELKNAAEEPEKEAKDKHEAAWNAVKEERRKAKEAVVAGEAFAELDVNQDGIVDIPELQNHQEFDIDSDGTVSDEEAKEYLEDSDSCDLPTFTEKIWPNIKEIYKPPSPPEEVPAGEGEEATAAPVEEQPEGSDPRTVPPILHEDVKVVEGGSKEEEDKYRYSDDEDLYNDEDDEEEEDDELEDEDDLEADYDISKKRRGRRNKSEKTEGEDDEEKMPDYDEETKKLIAVADEARNNYNDADRKVRDMETEITGIKSYMELDFGPEEEFAALKGQCFEYTDREYTYKLCPFEKTSQRPKAGGMETSLGNWGHWHGPAEDKYDAMKYENGQGCWNGPSRTCHVNFHCGAENALTGASEPSRCEYQFEFTTPARCAAPDSREHAVHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC88</accession>
    <name>A0ABM0JC88_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101863636</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101863636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090358.1">
        <property type="nucleotide sequence ID" value="XM_005090301.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863636"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005090358.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17897" checksum="0D348F8BDF636D5B" modified="2025-10-08" version="1">MAFVVGSLLRVLTRPLQHMSSNAASLGCNNRSAHRCISTAFNQDFAGRYSALPLKQDLSNGLCAAQPVIKQCVRTKVRVYYKGSAWKRYNKHNIEKRLTSPGGLEVLWRRVLKGKHQLAVYERILPNTVNSKVLPPHHFKYRPHPITKTKLPKRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCH2</accession>
    <name>A0ABM0JCH2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2',5'-phosphodiesterase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090525.1">
        <property type="nucleotide sequence ID" value="XM_005090468.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860466"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048821">
        <property type="entry name" value="PDE12-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF37">
        <property type="entry name" value="2',5'-PHOSPHODIESTERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21171">
        <property type="entry name" value="PDE12-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2',5'-phosphodiesterase 12-like N-terminal" evidence="2">
        <location>
            <begin position="188"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="318"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090525.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="71069" checksum="3675ADAE35A6EF02" modified="2025-10-08" version="1">MIARTRAISTVISEFSVSKRSFIKLFLRTGRCHQEQNHQTSIYQTPARVSCRRAASNFTKMSSVHVKNFEQDDRLQISLDLVKEGKTKSFNLNRLKTETLSSAVERLQTNLAKKLVNKKSKKKKAKVETETGTATTTVGSLEKDESEIPVAVLHNGLAADLSLTNIDAWIDGAVLKVGDEEIPVSLNPPSAKLEKLPRVIMEDFPLYPYAEFEFVDVKECEFFWKTFPSKLLPIVSKSVSSGDIDLSDAVSGKSYTPTSSERDYHVLLACVPRSGDRVGKLDAVISSAKVSPGPGPCPFEKRFEFTNIPSQDGLFRVLSYNILAEMYADTDVARTQLFAHCPQQALDMSYRKQLILKEILGYQADLLCLQEVDRSIFRSHLNPALSSNGYTGLFRSKAGQLGEGCATFMRDSKFRLVRELDITISEYLSSHPDCVDIWTEVCKSEQLKQKVEERSSILQVTVVESVENPGSYLCVANTHLYFHPRACNVRLIQGATALRYLQSVCQTYEQEGSQVALVFCGDFNSDPLVGVYQLYTAGWVPADYQDWDSAGPEEKITGLELRQPMNIESACGTPKYTNFTPMFNECLDYVYIDADKLKVESVVPMPDHADVVANAGLPSVVFPSDHIALICDLKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDW3</accession>
    <name>A0ABM0JDW3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane emp24 domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091437.1">
        <property type="nucleotide sequence ID" value="XM_005091380.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864504"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045981407" evidence="9">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005091437.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23947" checksum="7010F40C8AB687CE" modified="2025-10-08" version="1">MDFMHYVFVLFMATVLCADAIRFHLSSNQRKCLKEEIHKNVLVTGEYDVQENGQRADLSVTDSRGHILYSKEDATKGRFAFTTEEYDMFEVCFTSKPVSGAVAPDREVYLDVKRGIEAKNYDDIAKAEKLKPLEVELRRLEDLSKSIVDDFAYMRSREEQMRDTNESTHSRVMYFSLFSMLCLLGLATWQVLYLRRYFKAKKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE02</accession>
    <name>A0ABM0JE02_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibrinolytic enzyme, isozyme C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091516.2">
        <property type="nucleotide sequence ID" value="XM_005091459.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861935"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="83"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005091516.2"/>
        </source>
    </evidence>
    <sequence length="328" mass="35464" checksum="39E3C5D74D0CD3B6" modified="2025-10-08" version="1">MACHIKTWTEPEHIYLFPTTSPAVYKRRTSFCGAIICQRAAVTTPVQQSNSQPPLCPCVSDVMKLVATILLCLVASAVSEKRIINGDYAELYSHPYIVSLEGYIDNFFYSYWTHICGGSLIDREWVLTAAHCVESLSSSRLRVNLGIITLDKPNSYSQRSGVSKVVIHSGYKSSGSGIPNDIALLKLSTPAVINNNVKTAKLAPAGTSFAYTECVLAGWGKKSVGSQLVDSQDLMEVNITKISTAECNARWPSEAITDKHICVHDASPQVGQRPSACMGDSGGPMMCGSGHDILAGVTSWGDRACSGDTPSVYTRVSAYLDWIAQNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH53</accession>
    <name>A0ABM0JH53_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide exchange factor MSS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093561.2">
        <property type="nucleotide sequence ID" value="XM_005093504.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854482"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276:SF0">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005093561.2"/>
        </source>
    </evidence>
    <sequence length="134" mass="15130" checksum="B3CA7BDBD5291E1C" modified="2025-10-08" version="1">MAEATDTDPIEESKRVPESTLAEISDADGKNKTRIICRRCPSVILSPCQAKLVEKEFFLPNMFQKNERAPLEGVTLTDYWHVSDMMTFDNVGFSKTVDNIKYLICADCEIGPIGWHSVLDKTAYYIAVDRVKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHF4</accession>
    <name>A0ABM0JHF4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein Rab-43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093727.1">
        <property type="nucleotide sequence ID" value="XM_005093670.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851022"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005093727.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24212" checksum="451D0D910C4F6B98" modified="2025-10-08" version="1">MAYHPASDPDESFDYLFKIVLIGDAGVGKTCVVQRFKSGTYTEKHGSTIGVDFTMKTLNIDGKLVKLQIWDTAGQERFRTITQSYYRSANGVIIAFDISKRQTYEAVPRWLDDVKRYAGSNVVQLLVGNKCDLESLREVSKEEAKNFAHSQHFIGALETSAKENTNVDDTFLKMAKELKRRFGDDTNMDPGQPSNIHLNSRSLGGGKSWLPCCGSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKW4</accession>
    <name>A0ABM0JKW4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101862263</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096108.1">
        <property type="nucleotide sequence ID" value="XM_005096051.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862263"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046063385" evidence="5">
        <location>
            <begin position="20"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="892"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005096108.1"/>
        </source>
    </evidence>
    <sequence length="1079" mass="120508" checksum="92A54FC73B043435" modified="2025-10-08" version="1">MFVLELLLLLIGFLAAGSAEENCGWPKQIILTKRGIQYPSLDFTSSQTNSTTDVLCQTVVASDNGVSVHVWNYNITRGLSFKLTGILFEYDTIDIAWQYGQFADYLTVWRAAFLVTYSRPAGTTSANEHGFRLGLWYVMQSQSPCSEGRWSTFTASPRTRLLYPPGYLGKNFMFREPVSCKWKIAAPPGFVLDVKLVTISPDADIEINGKNGRYVPRIAGSKNVTITSQQKAKGFVVEYTAVPMETRSCSVNNTDVLTGLGDWYVLDWSIRPSGNEDVLECGITFDSGSDSRVVEVTVTDYRPLTSGQSCADQTVTVIDESSGVVLLEGVRPEGPANCTERTFPFSTIRASGRKLSVFLFDKKHSDVRETGLTLVVKSRDINSQVLDPAAPISYAWVPAGQISENDTLMMTLTQAVTANCSVLEAMDKNLSSQLVLSQKMSVFNGPSEEYFELTKDCNGKVLNNTALFPLESVSLVVHGQSEGFWIKYQANRDVPCERVYTPVTGASYTLSETVQQRKHLDCYWHLINDNGLIGVKTNFSSYDIDSEVQSFFFWMASHVSFDAPATVPGRLSVLAGDGDHNSHQPLLTNSYFLIDPDLWLYAASNLTVRLEVDTPNHLTNLEFQYKTLPSENWVQKSCSMLIINATSEIQQVETFNYPDYMMSDLDCQWNITRADPSHLVTLEVSSLRYIALCEGNDRPVQLTVYLYSEGDTSGTELDICGIRGFWGFAQAFAQETVVLRLKVAQPVIRGLYFRYSSIDPQDTEYRACNETIHLGDTTVSRNVTFYPHHFPGPTVCYWRFLSGSESQAVILTNVNFNFIPPNWQNQYPPGKVDFISVVNGKPKTILSTETMTSDSDVVSIENEMLLQVDLTEYLARKMTLTFTANTVPITGCNGTTLTLTVPANGAYQDLTSPNYPDHYPPNSRCAYILRSEDDTKVIEMSVHDLDIPKLSPNLTCTYYMIHDRVVIVYDEYSRFTLCNDGQDHKKPIFSSRPEVKVEFFSYEAQQGHGFLIKYRAVDRHHSPPSSKSPDDDSLVAIVCGSVAGFMGLVIIVAVLIRLRRARSHTQTTKVSVMGQAKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JL35</accession>
    <name>A0ABM0JL35_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine-rich cell wall structural protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096236.1">
        <property type="nucleotide sequence ID" value="XM_005096179.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850795"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045860854" evidence="2">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096236.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="22677" checksum="238B684BEA8B0EEB" modified="2025-10-08" version="1">MKFLAVLVLIACAVAVANSGRTKKYGGGGRRGGNAVGHGGSYGGSHGSGGSGSYGSVVSKGYGGSSGGGGYGGRMSSGGSGGSGGYGGGKSGGYGGGYGSGSSGSGGHFSGGSGGSRGSSSGMRSGGQHGGSRGGQGSGGMRQGFGGGYGSGSSGSSGSRFGMFSRGGGSGGSGRGSSSGGHGSRMGGSGGSRRGSSSGHGGRGSGSGMSGGRRGGQMGGRNGGRGSSHGSGMRQGSGGRASSRYMGHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLM8</accession>
    <name>A0ABM0JLM8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Schlafen family member 13 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096594.1">
        <property type="nucleotide sequence ID" value="XM_005096537.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852919"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="entry name" value="Schlafen, AAA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029684">
        <property type="entry name" value="Schlafen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155:SF30">
        <property type="entry name" value="PROTEIN SLFN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155">
        <property type="entry name" value="SCHLAFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="SLFN_AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Schlafen AlbA-2" evidence="2">
        <location>
            <begin position="171"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096594.1"/>
        </source>
    </evidence>
    <sequence length="964" mass="108421" checksum="586C045DE4328140" modified="2025-10-08" version="1">MITSANIREKSHSYGDIFVSCSVHISKGIHSKENNNVLESTCALLNSGGGILVMHNVEHNKKVQSKTLDAWWSGMESNLANILSGDDICNYLDFVGNFDDKYFYLFVKSAEHLCTVEYHCRLPTDTATHSVSYKSAAKICAKQGHESKLSDLPVIPTEYEFGVTEATLKQEGKQIQFKQLTSGRFAKRQSFPEKVGYYCSRYITAFANHEGGHIYFGIEDTTAAVMGEELTEEEETHTVSVVEKKMGSVIWSDPDCQPVRGVHWDIEFFPVFHCPDEERRRVIVVSVCKMPGGVFSNCPEAFVVSRSQDSNSNGDNKVRPRVEKLAFRDWKAEMLSKERDVKMLRSRFVKIPMKSPRSRLIYSLPHTLQASREKVIKLRTEFNLQPKNVLHSFSYAKVKDTVRRLVENFVGEPHLVVSLEAWGLELELPCKPEKVKAVLAVFSSLYGLHVVSVTSGALEEEGMWQFTKEVAVQLKQVLVHHGGCSTHLGFKVHVVDVDGHLMMEYFQSAIDIDIYPQTYKPSEVKMNDILNSLTVAIASYKPFSCKDDADYYFLLTCDQLELMWSHQFTRDLWVHGPPGSGKTIAALEMIRELRRRGCGCEQILYVAENPLLCSYVNSFDLCTVVSRRQLMSDGDRDRRYKNVLSVVVDEAQNFKDRDGDWYSFLDNLSKQNVKSPEDLKAGYFWLFMDYAQKVHKFNAGLPGLIGKHNFMLREISRNSKEIYEYATKFMEKPSCAVQDGVERNLVSDSPHLAHEYKSGQEVNVVPCKQATVIDMLKEVLQQYTQDGVSVSDMAVLVSKKKEVEEVRELVAKEDLGKSLNLVAPEESRMVCDEIGESSSCASSSMSVPMETSSEDGICESSLKDTSSNSTDNTNTNSAGITCTTNSMAKPQTSSQLSGKSPLLVTTVRDFSGLDKPVIIGLDPHTNQEHADFDKFLLNLVTRAKDSLVILTSSDALLNKLRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM59</accession>
    <name>A0ABM0JM59_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101855184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005096936.1">
        <property type="nucleotide sequence ID" value="XM_005096879.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855184"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005096936.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24095" checksum="47FBA10077818237" modified="2025-10-08" version="1">MATSSVVPYEAKTARKVELNEIIPPVDFSFLKIASVDECESEEPRDNSPRKQRAVQKKKEEEKDDKSDSLCLKLNNNELKDVNNIMSIAEMLFQNPSSIGWIDLSFNSLTHIDPVLTQFENLKILYLHGNSIEDVKEVNKLAVLPRLIKLCLHGNPMENVKGYRQYVLSFVPNLVVFDFSRVTKADRATANTWKNFNNPQRQKKIKNNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNX5</accession>
    <name>A0ABM0JNX5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Interactor protein for cytohesin exchange factors 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101846580</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098098.1">
        <property type="nucleotide sequence ID" value="XM_005098041.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098099.1">
        <property type="nucleotide sequence ID" value="XM_005098042.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846580"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035848">
        <property type="entry name" value="SH3BP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15126:SF4">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15126">
        <property type="entry name" value="SH3-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="265"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005098098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005098099.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41402" checksum="E0B6453F8192CC47" modified="2025-10-08" version="1">MASDYDPGILGVVVPQKCSCQFLLSGTTIVQSGWLRKKSLRNKIQLKIFNWPQMFVVIADKCLYYFSNELAKKPAGAVSLYGFNRIIRFRQEHPNDPSWAFKLEHVQPDMRSFYFAASSEHELIKWMKVIKQEMLVANNRSSTRAKAPSSDGISLASSGSFGSVDYHDIEASVYYEPTKRRPVSTISDFTSNAESEYHEDVMFEDSGEFEEISEPSDSPPKETFMASLVQGLKERQLQKDAVSQGYCLQTVPPPVSDNRETQTYWSSVRFHGSKEEASKAMAPVSEDGVYLVRKSEDLSDVLLVRSGSNSRKYRIFVKDDGKLTLSPTSPCFDKLEQLLFHYYSNDLPNSVLRLSAPYSIYVGQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPG4</accession>
    <name>A0ABM0JPG4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA 3'-5' helicase BLM</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC101856181</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005098478.1">
        <property type="nucleotide sequence ID" value="XM_005098421.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098479.1">
        <property type="nucleotide sequence ID" value="XM_005098422.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856181"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="688"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="884"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="1217"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="182"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="386"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1321"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1333"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1373"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1425"/>
            <end position="1440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005098478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005098479.1"/>
        </source>
    </evidence>
    <sequence length="1440" mass="160268" checksum="344C287A9B3E1A37" modified="2025-10-08" version="1">MAAEKATFKGFTFKRAASKSAVPGSTLPKGTSDRKTTPVSLPSGNKGSSSDIRITSAPLSSDRKAIPHLGKSISAPISSGSRSTPCDGKSPSALLSSGGRATSAPLSSGSKAACHDGEKKQPMSKSGSFQTSMTSFAKNKPVAVAAVKPQRALPPQVMKEDVSTTGLTRDLPVEIFDDDDDFETLPFSQSDHQSVVAAHRGERSPKRRRKEETSIPDVIPDTPDKDDPLDGVMPRKKKRRTLPIMESDEEQTPSRTSSQKNCSRDLEEKCEDICQHPLLKKGLNTVKPEEAVELMHILLRVVDEICDIFNKIPIKTLFDLLLDDFGRLGELLKVRKQIKDTMDLKKFQGKMRSNPALGRKSSPGHPLASTPLLSADKTELKRKKLALKKSPTKSPAVSSETPRSQVASFYDTSGGGDMVRGKNESINKNYYDDKRLSHRKPNERATTSFDSMNDKSLMCGQSNFRSSLGCNSSQSPVSRLNSSSRHSEMGGLKNSPSFQKNADIEEAYYDPHMEERGFDEEMEAALAFDESFEEADHLKKTDSSVSKKMNSPNKNSVEKNAPSLLSPGGSKVRQQAVVNDISSRSLDIRDVEDEKMLDSLVDEAAAGVNSYHIEDDEYYDGFKEDQERNSQQRFSDSTYIPVFSSSDHDDGASSEFAGFKFEHSTKLQDKFQEVFGLKEFRRNQLEAINAALLGHDIFVLMPTGGGKSLCYQLPAVVFEGVTVVVSPLKALIQDQTQQLLSRDIPVANLSGDTDGDSLVYSGLYQRKPAYRLIYVTPEKLSVSGKLLNCLGNLHRRQQLSRFVIDEAHCVSQWGHDFRPDYKKLNLLRERFPGVPTMALTATATPRVRRDIIHQLDMNNPKWFMQSFNRPNLKYSVQSKKCSNATTDVIQMIQSRFRNDCGIVYCFSRKECDNVAMDLRKAGLLANSYHAGLDDNKRATVQERWLNEDGCKIICATIAFGMGIDKADVRFVIHYSLPKSMEGYYQEAGRAGRDGMIAHCILFYTYSDVKRIRKLIELDQSATFDSKRVHIDNLFAMVGYCENVTDCRRCQLLQYFGECSFDRAMCASFAGAVCDNCHSKDSFNLRDVTQDAKEIVKCVRELNTPHGNYTLIHILEIFKGSQNSKIKSLGHSKLALHARGKDWTRNDAERLCRKLVIDRILKEDLQVTAMDHTVCYIRMGPRAADLMRNQIKIELPIQGKRKRADAVKIGTEPKNSREKIEQDCLTELRALAKTIATEHNFKNYALIFPESALKQLAQRTPITVEEMVDQIDHFNVTMVEKYKAQRFLEITLKYSMEMMEVETDANTAEEGSEEEWASHYFEETSSFSGASRGRGQRGRGGKRGFSKGRSSFKRGRGKGRKYPARGKAAAKKTAPSSFSQYKYNSGSSGSSGKATGNMATTGGPPQPRPTTVTKGTLGLMPDPRSRSFLSSHSKSGGSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPL3</accession>
    <name>A0ABM0JPL3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098565.2">
        <property type="nucleotide sequence ID" value="XM_005098508.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857115"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="256"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="418"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098565.2"/>
        </source>
    </evidence>
    <sequence length="1030" mass="118479" checksum="BFD4C0CB1483837B" modified="2025-10-08" version="1">MHEKKKHHKHKSRRHTDDQDPSSDRTTDESPGHQLQDADNPEQLTDQHTEEATEQPGVSSESDSNAKPNTTANDHVASSSKASITSSLGFSFRKSSGVRASQVLAFRPSKTAEADMEIASLSDRKYSEENENDASLLDRDDMSQSLVDILDDNEPRLETLTPPPPVPEIDDGLVHSALLTVRQSFTEKTVLEELQKMFNLYEDSQNKTLTLSRKLHKYTRIIERYEERETKDPRLKKALFFANEYRKSAKIPEEVNKKLTSEAEEYRITISSMKENLKGLEKKCKLLQDENSRLKKLEGDMEQQETVKMTLENKVESLTKQLKEVTVQCKTKSEHDLKKIQEEKAEIMEMTGLEVQRLSKKLDMAVSAKQTLLKANEECTKQQKILESKRQETKAALTCSIAQEGALMKTKHALDVHIQSLEKKLIKEKSEQKELEAKLKLANRHLDDFKRELTTAKDDNAKLQQQVKDLASKNDFLQNRLTKAVDISKRAKGNLDVCKTNQTHSQIALSDLKLGLLTCRQHLKTMTLQCDTIKTRLNEALQQVNSKEELLRTSQSNALSATRAIHELATLNSTQDVAIKGLQDDLKRMSNQFSLMIAKMREYAMDHDHLTSYILTIEKDRQVLTDQKAAQRQQIHILGRKNASLYTNNASQQEMMELMRFQSTLKENEISGLNFSHKKKDAVIMSLQLKESDHVDRLASKGKELLKLSDRVSEVREEMDTAKNQLFSMQSILKCTMEDLRIETLRKERIRKERDLFGAMAAQRKVEQDLLQERVRALEKRLQHGHAAFLNKENDVKVLVLEVNNLRRKLKLYDRDKQVLYELRNEHIEVRRDAIRTQAKCAAIEAMLPTRLHRWTVLKAEDPSQYELHIKTRLLTRKLIKKTVEVIQKEQIIMKKNRLFMEMKAMLALKSPKDLSNQVVEASKAMGRKDRQIKALKAELTVSMYSHSQAQKEATKKEQELGETRKQYLRQKKINFRQRQQQNKLPPIKANPPLVKGCGGGFRWTSLIAAKTNTKVYPQMLVSGNVRPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPY0</accession>
    <name>A0ABM0JPY0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18 19">Inward rectifier potassium channel 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18 19 20" type="primary">LOC101847038</name>
    </gene>
    <organism evidence="16 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098785.1">
        <property type="nucleotide sequence ID" value="XM_005098728.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098786.1">
        <property type="nucleotide sequence ID" value="XM_005098729.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098787.1">
        <property type="nucleotide sequence ID" value="XM_005098730.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098788.1">
        <property type="nucleotide sequence ID" value="XM_005098731.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847038"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="164"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005098785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005098786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005098787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005098788.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57613" checksum="11492BA8B20F5EB8" modified="2025-10-08" version="1">MNLCRRRRQVDRHLSRKRLMRSAGHNIVSVSVPDKHRKYMSDIYTTLIDIQWRWNILIFVGVFVFTWVIFACFYYLLGSLHGDLETNSTITPCVENVNSFTSAYLFSIETMTTIGYGFRSQTEECPGVFLAVMLQSILGAGLQFALASVVVSKTRRAKRRSGTVLFSDKVCIYEDNTHLQLSVRVGDMRKSEIAGAHAKGFLIKKYRSHDGTFVPVRSYQVSFKAESGRDEIFLSWPTQILHKVDEASALWSLSRDELLSGKYELIVVIDGVCVSTSTPFQARKSYHTTEMVWGHRFSDLGLSLNCSGSYDMDLSNFNGTVPASTPLCSAQDINHLREMYRANHPDETVGERPNEGSLSKEDVRGSQVKEKSSKVLMQRRSHSMEEATGKPRGQHNRRCSLGDLIRTAQGEGAGGGNRINHLGNALNIYRHRLSVTDTYLGSDNILEEVDEDDDENNQAILTVVSQRSQDRLERRTDVRDVFKKKKSSVTQLFFGTEPAKSGEEGIGGEGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ56</accession>
    <name>A0ABM0JQ56_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rieske domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005098944.1">
        <property type="nucleotide sequence ID" value="XM_005098887.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862186"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054716">
        <property type="entry name" value="Sol_Rieske_ferrdox_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22543">
        <property type="entry name" value="Rieske_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005098944.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15598" checksum="4ABA45AF2BFEF9F9" modified="2025-10-08" version="1">MSESILVGQLSEIIRVGGRKRLTVRGRDIFIIARGSELFALDSFCYHAGGPLHMGDIEEMPGYTCVVCPWHRYKITLRSGEGLYHSIDPHNLSKPPVLCSKGVKQRTHLVTLEGDDVYVTLSTGDPAHTKLESDQYNSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR49</accession>
    <name>A0ABM0JR49_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">COP9 signalosome complex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101852323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099578.1">
        <property type="nucleotide sequence ID" value="XM_005099521.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852323"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="52"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005099578.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37716" checksum="14088C9E35EA2232" modified="2025-10-08" version="1">MDSKVARKTWELTNNVESVSSVDEIYRYDSKQQQDILTAKPWEKDPHYFKHIKVSALALLKMVMHARSGGNLEVMGLLLGKVDGNTMIVMDGVALPVEGTETRVNAQAQAYEYMAAYTEAAKQVKRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAIVIDPVRTISAGKVNIGAFRTYPRGYKPPDEYPSEYQSIPLNKIEDFGVHCKAYYPLDISYFKSSMDRRLLESLWNKYWVNTLSSSSLLTNADYTTGMIFDLSEKLEQSESQLGRSGLISTDSQDRKTEDKLTKATKDGCRTTMEVLQGLMSQVIKDRLFNQVGCKPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR89</accession>
    <name>A0ABM0JR89_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 17 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099671.1">
        <property type="nucleotide sequence ID" value="XM_005099614.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854723"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031620">
        <property type="entry name" value="DCAF17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14815">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14815:SF2">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15802">
        <property type="entry name" value="DCAF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099671.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="63918" checksum="2989BDDFA987262F" modified="2025-10-08" version="1">MPMLRLYKASSLDKSCNVYSHLLSREYTTVSNHRRVHHVMGTLTTRGNYTFKKVWSKVSKKHIACDGRWAFFDNYEDCFDCGSPRRAPHKRFSLHKDKLAKIEDALIMEGIADSVELRHRNHKSCLLALTKDNMLLRIDLDTGQVMEQVYLGPTSIRYKKIQWNMVDESFTLCSMLFPRQPVHFLRQAGMEVTDVIQLTILSCLPLDFVCKMSVTRQVFGKDTVDAAIFLNLLMVMHSMSHVRMYSLETIMKQGCLHQQKLYDKLEDGTTYGIYPSPVTVSVKLEERPPCLFEVRCRNRDVMLTMPPCYYIMWPFGNYRGYCCFSLRTQEMVEGGCLQAEDSAPEERVSLHADDSGRIVHMKNAELRVLKLQAQANDEERKLVEDFVINFTPQPQSPILQVTQSGRIIKQTVRQDCSQLQERTVLTMMYSEDQDMMIVVSVSTPGCDKVDRPVVGFYNNWTGQLLRQFELEESLEETQDRSICYQMDTITHVFKTYQQRFECHVYKLLPLSTPGEEWKGRAKGGTHRRSTPRVSTDSSEDGEYSPRRRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRB8</accession>
    <name>A0ABM0JRB8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomal protein of 19 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC101847042</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099719.1">
        <property type="nucleotide sequence ID" value="XM_005099662.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099720.1">
        <property type="nucleotide sequence ID" value="XM_005099663.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847042"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029412">
        <property type="entry name" value="CEP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19K CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14933">
        <property type="entry name" value="CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005099719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005099720.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18860" checksum="90766D2394FCB01D" modified="2025-10-08" version="1">MADSVQLMKCGVRFQPPALVLSYKDWKTGKLRRRSMPLRNFSKNSSIDRTVEDLKASPRHARFVRLLSTAQLQRLLTIIKDKLSGLSVEASVARNNAMDTLNPEENLNKVDEETLQRKKLQMDTSFEKHRKRPGDPDFQYNVEVDFDAAVVETSGWDSDGSEVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRG4</accession>
    <name>A0ABM0JRG4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Globin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Myoglobin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101852695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the globin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099823.1">
        <property type="nucleotide sequence ID" value="XM_005099766.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852695"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="4 9" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="10">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005099823.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20980" checksum="1EB9C124444DF792" modified="2025-10-08" version="1">MGCSSSSNKQEDECGHQVDYFLSPDEIRIVRESWAVVALDLPATGLHIFTRLFEMEKDLKKLFRRLMSQTESGEFIFDTIRLEHHATLVMKNLGQAVDNLDDSEVFSEMLVLLGEKHSSYNVRPAMLAFLWPAIRDGLKMRLGDKFTVETELAWKHLYDYISCKMSDGMSGRHKNSKKILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRH0</accession>
    <name>A0ABM0JRH0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibropellin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099831.1">
        <property type="nucleotide sequence ID" value="XM_005099774.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854953"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046057927" evidence="2">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099831.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="15869" checksum="165DBC6E7C79C0AD" modified="2025-10-08" version="1">MSALFQVSVVAVLFCCVAPSLGQLPSPSQKSENPCDGFPCFNQGVCIAIGDKPSCVCQPGYTGNMCETADPCSSLSCLNGGVCRAPFSTPYCDCPVGNVGTRCQTYAGIVLDPCYTMKCLNGGFCATPNNEAQCVCQPGYSGDKCQHYRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRH4</accession>
    <name>A0ABM0JRH4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC101857027</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC101857027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099840.1">
        <property type="nucleotide sequence ID" value="XM_005099783.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099841.1">
        <property type="nucleotide sequence ID" value="XM_005099784.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938792.1">
        <property type="nucleotide sequence ID" value="XM_013083338.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857027"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23955">
        <property type="entry name" value="UBCc_invertebrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012938792.1"/>
        </source>
    </evidence>
    <sequence length="672" mass="75448" checksum="9A2C00E7A1A812D3" modified="2025-10-08" version="1">MAAKNKKAIQRLMFDQEELRKAPVANVSAAPLDENMFEWHCNIRQDDIIFHLILFFPQNYPYSSPSAEFVPVGFNYSSGATKPGKKGTKICLNIFSDFADIHTEWKGQKGLGWSPGYTVQMVLMNVVAFLAETQDNGSSSHSFKQNLKLSKEFKCEDCGHTYRTPQPSLDDETDSGESKKGKGKGAKGKKEGAATAKAQLAGKAQVAEKAFDAGPEIIDYISKEKFKIKKPSGVDDLFGYGLAVSGTNWRPVLTSPCEFITGSSFFGMKKAVKVVHSVMKEELKLFLPLYIHPIHGAEIKDEFEKTLKEVAVIMPKHDPNTTPITDLVLKTIPNLMSATVVEFSKGTQHTSDNSLNGYFALHRLLLWAADTYPELQDAIETKVQEYVEDERNRTKSKVPYIAEWLMLVAASKKYRWQDVADAYLSESWRRNVIWYVKADAKLGFLDTPQDYRIRRTLEETDIARKHLAFQVRFLDIAMPAKMSRDEVIKRYDNNFGFPTKEMVDELKDAFVKINNEMKTYQDWFKILKLPVLTDKQVFDVLVEAVKFSIVRPGYFWSSAKTGGGWAQVFEKYADMRRESFEKYKKEKEEREKAAKKEDGGAEGDKEEESSEGKGASGKGRRGGGRGAARGGRGTARGGRGASARGGKGAGRGRKRKSSSSDDEDWGGSKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTY0</accession>
    <name>A0ABM0JTY0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serrate RNA effector molecule homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101863681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101409.1">
        <property type="nucleotide sequence ID" value="XM_005101352.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863681"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERRATE/Ars2 N-terminal" evidence="6">
        <location>
            <begin position="174"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="SERRATE/Ars2 C-terminal" evidence="5">
        <location>
            <begin position="722"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="830"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005101409.1"/>
        </source>
    </evidence>
    <sequence length="947" mass="108767" checksum="E5909F4BB85E21AD" modified="2025-10-08" version="1">MGDSDDEFERKKGRDKFRRERNDYERRSDDRRRDNWDDRRPSMRGGQRGWRGNPGGGMRSRDMWSGRGANMRDRRDMYSRQYDDRRRDRFSPGRFDGGPHPAKRMRRDWDEGGYSGMYESPFQVSNGPPGADRAGWTPRNMEVSSGPPDRGGFPERRDAIDPEHPTQPPLMTFKQFLNKQEDTISQEDAIRLFEDYKLDFRRQQINEFFLAHKEEEWFKSKYHPEECDKRQVEVKAALESRRKVFEALREKKFFEDISVDIDCTDSLIKIMDAAVILLEGGNDLDLTILDNPLLEPGERSRQNSETVTSPIKTDKKKSDDEDGEISDSNPTKTMSDSEQEPTDQTDKKEEVDEDKDKDQEKKAEPKDQTLEMTITPEQEELKKKAMEYQKQQEAAAAEAKAQRRKKKSMRKKSDYSYESDSESGSESDSDPEPAPPGLEDDATAPPGVEPEAEPKSTVDEAGDRAEKEPEGAEEDNKAKEEKEEEKPRPLHRTNSIFLRNLAPTITKQEVEAMCRRYPGFIRVALQDPQPERRFLRRGWVTFSKECNIKDVCWTLNNIRLRDCELGATLNRELKQRIRMANGLTVHKQVMRNDIKMAAKIIQILDKKWGLWEDEGEEKKDNEKELQFGFVTKNPVLKNITDFLVEEGSFEEEELIGESDDDKKDANHEITVEKDLSLCLALDKMVLYLRLVHSIDYYAANEYPNEDEMPHRCGIMHARGEPPGPTAKMTQTDVNEWMGSFEKKIKPFMEAALKISDTEAAQLGQKDPDVEVEKFVQANTQELSRDKWLCPLSGKKFKGPEFVRKHIYNKHGEKVDEVRKEVKFFNNYLVDPKRPALPEHPSSRPKPPPPAAPAASPQAAPPQRADPYGNNYTSPGGAIGFSQSRPPLYGGGAGAAYQSPFSVRDNRPPPDNFRRSNFGGAARPYRRSDPRQLIQYTDLDAPDDGDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU99</accession>
    <name>A0ABM0JU99_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101857955</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101633.2">
        <property type="nucleotide sequence ID" value="XM_005101576.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857955"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045391844" evidence="2">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101633.2"/>
        </source>
    </evidence>
    <sequence length="376" mass="41678" checksum="BF71F32BACBAF777" modified="2025-10-08" version="1">MFTSFLEIFLLLYNRKVFSLTKCSRAKTKIASLRLEKEIHTCLAEKSSLLEKLKAIQNSKQYEEVEDSDENNDHQGNSLHMDVDEESDGDGKEKAIMKESTDFTDTTSIEDQQSGCQETDWKMNDSSQRTPSRSTNRGSCTDKTVEVQAFMEHEVSCCGDNCMKIANSRGSHSARVPWIVTSQPNSRLPVPVSGKANTILSAHTSEGQDTCKPPSLRLPAISVPRPPRIKTPVRMPRPLPVIEIPSHVTLPPRMKEPPAPSRFLQSTHSGTAVQRPFTRMFSTPQSQCVAGLPMSKPVSLAQGSSALSAQVQEKSAVMEHMTPSGDGGMSREQNREGPLKSTSGTEETRSLKGVLVRSILRLFFLLPMKIYEHFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUF5</accession>
    <name>A0ABM0JUF5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101845175</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101749.1">
        <property type="nucleotide sequence ID" value="XM_005101692.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845175"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047354015" evidence="1">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101749.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20151" checksum="446D5723DBD92C4A" modified="2025-10-08" version="1">MQFLALFLLVAPVAYTLAAPDPTTICLPEKSSAYVFSLTDNRKANVSADFSQNKVAAVYDQGRRVSDLATNYTYMIDAAGACTRQPLPVLGFLTRCLPAKAVYLGTVFEGFVKKVSLDGWLIPVNQDTNVTLLTFTEPGQSNSYFVLRRDDSPRGQRITFVSNPVASVADSSVFNIPAVCPDSPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUI7</accession>
    <name>A0ABM0JUI7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sterile alpha motif domain-containing protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101816.1">
        <property type="nucleotide sequence ID" value="XM_005101759.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859794"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46829">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46829:SF1">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101816.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17021" checksum="99316E36CF729D55" modified="2025-10-08" version="1">MASVEATIVEDLKDPRVPSALYWTIEHVADWIEELGFPQYRACFLTNLINGRKLCCLHASAFPDIGITDFEHIKIIAKNIRDLIYLEEPFWNRSIADPPKNDLGMYLELKSSTGKNIDTTTLKQMYLNNPDPKWQPPLSNQCMILPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUQ8</accession>
    <name>A0ABM0JUQ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein Rab-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101961.1">
        <property type="nucleotide sequence ID" value="XM_005101904.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853863"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101961.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23505" checksum="CFA258DBBBE49273" modified="2025-10-08" version="1">MSYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLEARREVKKEEGEAFAREHGLIFMETSAKTAANVEEAFINTAKEIYQKIQDGVFDINNEANGIKIGPQHSPANQNMPAGGSGGNQGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV46</accession>
    <name>A0ABM0JV46_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101858873</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102236.1">
        <property type="nucleotide sequence ID" value="XM_005102179.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858873"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C2 calpain large subunit" evidence="3">
        <location>
            <begin position="542"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005102236.1"/>
        </source>
    </evidence>
    <sequence length="658" mass="72603" checksum="EC1EA112E9A52787" modified="2025-10-08" version="1">MHSIVPVTPDLEIREEPKLTGVGGICDEPFPWQQWKQRGWFQAALVLVSLSVRSLERLIPGFRNNEQNFDADYIGVGYKDRGRRSTAPHETYAREFAKRRTNSDSDCYTHFYIDSASAPCSPFLKPYRLENRFTEAAGSGSVQTSRSRSPSAKASKKKLSMSKDRKQRTRNAESGSEENKPSTGSHGWLSSHRLYHSPNHQQQLQQQQQQQQQQQQQQQQHEQGGSVTNTSPDKPSQGSSCLPSPRRRKSTGEKLKETFSSITGGSQHSQHDSDSSSGPSGSHHNSPTSGARGSHVLKKTLKSNFMKKHSLDHHMHGISLPSHFSVSVDSTSSTADSVDSVISLTGDVASGDESPSSSPSAPSPLCQQQQTAPPTSWTTPTSPDAGVFGSPETSSIVSSTTHTPDEPHTSSSSPVFNICPPTPARPGTSESCYSVSDISVHAKGDNSSPPSCLASPRRPQSAPNNTGLNREVSSGSLSSLTQSSFLATKADYFRSDGRWKLILEHRDAWRRDTPSSDRTRMDVHSKTHRIYFLVTRHEQRDPLVTPNVQDKRHVLISLLQDYRHGPSTANSLLVPIGFCLYRAKHFDRDEKRHISKLQLIGHVDGEADRREISARFDLDPGGYFLVPYYQADSHQGEFILRVLAESDIGQAKAGCKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWF1</accession>
    <name>A0ABM0JWF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone-lysine N-methyltransferase PRDM16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005103118.1">
        <property type="nucleotide sequence ID" value="XM_005103061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860908"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027756">
        <property type="entry name" value="Ovo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032:SF271">
        <property type="entry name" value="RH12261P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032">
        <property type="entry name" value="ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005103118.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38568" checksum="2C249BBD5C37C707" modified="2025-10-08" version="1">MAEVSVIDKLPGQDINVVMGDLNAKTYGQSGEQDQPVDLSLNHDRSYPPGGLGYLSAGGPGIVPQNYPAVPMGAVSQPVVSSSTHHKRNADWKTVSRRPRQRVDDWQNPAPIVEPRFDDCEERGLFVDKYFQPPREPDTEKDQSLMIEQLLRLYHASNLPPVPEEQRSNLLFLRYYAQMKTLIRIKHKRPGFKLQLMDSCDHMAFKNFQRPKDTDDLIRPYILKLGDDQYACRKCSSPDESGVTSHSPCFTTEAKLVRHIQNHLNHYRYVCNFCNKQFNQTADMSLHVKIHIDVRPFKCGSCGKCFIQRVSLNSHLSKHHGDHTAVNTGMVVKKEAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWF2</accession>
    <name>A0ABM0JWF2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cullin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101861300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103119.1">
        <property type="nucleotide sequence ID" value="XM_005103062.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861300"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="404"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005103119.1"/>
        </source>
    </evidence>
    <sequence length="777" mass="90631" checksum="7E41D5DDDDD5C019" modified="2025-10-08" version="1">MTMLGQHGRCKFDEKWPSMRPTVLKLLRQESVPHQEWQDLFWHVHAVCMWDEQEGPTHIHEALHKDILDFIKQAQSRVLQHKEESALLRAYIAEWGKFFTQCNYLPKPFIQLEANLMGKLHSSMPKKAQSPDESLVRKLMLDSWNFSIFSNIKDKLQYSAMKLVHAERHGEAFDSQLVIGVRESYVNLSSDTEDKLKIYCENFEKAYLEAAENFYRQNAPDYLEQNGVQNYMRYADCKLKEEEARARRYLETGYGCGSVNSLVDCCVRALVTSFKDTILAECASMIKQNETEKLRLMFSLMDRVPDGIQPMLQDLETHIVNQGLADMMSAAETITTDSEKYVEQLLELFNRFSQLVSDAFSIDPRFLTSRDKAYKTVVNDTSVFKLEIPVKNKSVGAKSQPESKCPELLANFCDMLLRKTTVSKRLTPEEVDKKLRNVLLVLKYVQNKDVFMRYHKAHLTRRLILDSSADNEKEENMVEWLRDVGMPADFVNKLQRMFQDIKVSEDLNHEFKEAHRNNNEGIADAINIKILNAGAWARSSERMPVSLPLELEDYIPQVEEFYKHKHSGRKLQWHHAMSNGVITFCNDLGRFELEVTTFQMAVLFAWNQRPREKLSYESLKLATELPDNELRKTILSLMTSKNKILLSSNEIKTPRDFNDNTEFWVNQQYAFTKSGKVQKRGKTNLIGRLQLTTEKSREEDNEGIMQLRILRVQEAIVKIMKMRKKLTNAALQTELVEILKNMFLPSKKLIKEQIEWLIEHKYMKRDEDDINTFIYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWG8</accession>
    <name>A0ABM0JWG8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Male-specific lethal 1 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103149.1">
        <property type="nucleotide sequence ID" value="XM_005103092.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848369"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026711">
        <property type="entry name" value="Msl-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029332">
        <property type="entry name" value="PEHE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21656:SF2">
        <property type="entry name" value="MALE-SPECIFIC LETHAL 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21656">
        <property type="entry name" value="MALE-SPECIFIC LETHAL-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15275">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01300">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52052">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEHE" evidence="2">
        <location>
            <begin position="331"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005103149.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53763" checksum="2FF38A4DFEBF0B44" modified="2025-10-08" version="1">MKRSTMKSNIGVQPKCRPEGRLFPRRKVASKSLLLNGVGDFDMELSLAIQESLKYAKEKEDEVKQTTMLNSHAHSDKEDKCESGSVSNNGTEQSRTLNKAVSAVPMASAATSSDWAAEEVGRLKDLLLTQAELIQCQQDELIKKDKEIQALITGKDALQCRLERMERRMSILKHREEPQEGPSTKNGDDAMAKVSGSTHSNSVPKGKSEVSRKEFKRKRRGTKSNFSQRKQHKHRKLELSPAETASEKEESDDNRSSADSDDEEDDQTDSDHDSNEKENESDEDAGVSEIEEKIIDYPIMQTETLYHLYYPKHVFASVDTSTIPERPSQLDVETPSWRLKPLTNMYQLEGTENITDEAYYKRHQKFEMEEKRRKRWDLQRIRELRVFEKLQKQKEDELRASQDEVDVETFLPSVQDLKHIEVTESLPVMAFGQPVPYVSPAEFEIPWEVSSSGLASSSRQRSNSSHSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXP5</accession>
    <name>A0ABM0JXP5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101863919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005103973.1">
        <property type="nucleotide sequence ID" value="XM_005103916.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863919"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17980">
        <property type="entry name" value="DEXHc_DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="71"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="268"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005103973.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="68652" checksum="8E625D27F0052721" modified="2025-10-08" version="1">MSGDASSSGAPRFWKPGTAGPGLTKISEERTTSSDQSGIGNASVAYNPHRNLSIEQQRQKLPVFQYRNHILYLAEKYQTVVIIGETGCGKSTQIPQYLLEAGWGNEGHVIGVTQPRRVAAVTVATRIAEERGAILGDEVGYLIRFDNCCDEERTKIKFMTDGMMIREIMKDPLLQKYSIILLDEAHERALNTDIILGLLRKIQKKRKDLKLIVASATLDAEEMRNFFNTNETDDPEKDTAAILTVEGREYPVDVHYALDPVPNYIKASVETVMKIHFNERPGDIIVFLTGMNEVDDVVSQLISEARKLKKDSMKMRVLPMHGSLPAAEQMKVFERTSKYTRKIVVATNIAETSITIPGITYIVDTGFVKLKAYNPKSGIESLVIIPVSQASANQRAGRAGRVRAGKAYRLYTEEEFDKLPVSTAPEMQRSDLAPVILQLKALGIANVLRFHFMSPPPAQNMVRGLELLYALGAIDDAGNLTSPLGLQMVEFPLSPSFSKMLLSSGEFGCTEEALIVCAMTQIQNVFVTPSDRKMAAEKERRKFSVMEGDHLSLVNVYKSFIKYGQNSRWCHEHCLNYKGLNRAVEISNQLGRLLTKFKVKLVSCKGKTFLLHTVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ49</accession>
    <name>A0ABM0JZ49_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-tubulin N-acetyltransferase</fullName>
            <shortName evidence="3">Alpha-TAT</shortName>
            <shortName evidence="3">TAT</shortName>
            <ecNumber evidence="3">2.3.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetyltransferase mec-17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101849949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-[alpha-tubulin] + acetyl-CoA = N(6)-acetyl-L-lysyl-[alpha-tubulin] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15277"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.108"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase ATAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.108" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005104956.1">
        <property type="nucleotide sequence ID" value="XM_005104899.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849949"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03130">
        <property type="entry name" value="mec17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF0">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial for catalytic activity" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005104956.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="62044" checksum="4B956903C7087D4C" modified="2025-10-08" version="1">MEFSFNVNQLLKQEITKVDSQLQPCRQNGIDRYGFQQLQRMLYEIVDRMGEASAKAQGLRGSITTGKKLELAGHRLYIMKDSNSNGEKGAVVGILKVGTKKLFVYDHSKVQHELEPLCVLDFYVHESRQRMGCGRKLFDHMLRNEGLSAQHLPIDRPSPKFSSFLKKHYNLRGTIPQVNNFVIFEGFFSRRPADAGSNRGRRRNSVDGRPPMRPNSGHNIYASNNNPAANGYPQSWTNQRNHSGSNVNEDALNQLNVPVSGRPQQTANNMGASEMMYSRHGPSPPNMYNNNSSNNSAGAALQNLRQGPRSASPHNGSVYKNRNGLSPTPNVGMYKNLNGLSSPHMYYNTGMNPNKFYGQPDGLPPKHPSQRPNQFPENPSAPQRGPSSTPNFGNRSMGVDGGGSGGGGGGMNNIAQPASRRTPPVMLDPRYPQSPGTAQHFPDISHQTQTPASGGGVAHRPPSGDRGRLNNQAVANPPILHRDGPPRNYQNMLNMHQTFQDRGGHLKVPQGPPAVAVPGVSMQPSGPPLFGSQSSRDNTWTVSGVLRAQRMNGGLSSQHYNSSRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZC9</accession>
    <name>A0ABM0JZC9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101846601</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101846601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005105104.1">
        <property type="nucleotide sequence ID" value="XM_005105047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846601"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="85"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005105104.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44520" checksum="2922F86339680F9D" modified="2025-10-08" version="1">MTLSDELFTGHWNSSADRCPEPEGESLQGSFCDGNFTESMSNVSGNLGEIEGSAGWWLDTAVVLAVVQILKMAIIPAVSILGAAGNLISVLVISKSGLRKTSNILLFALSAEDASFLIGVNNIPFLLYTYVDGDADGWHFSESISHALYCFYFVFAWFQNIGLWCSMTILAFMTIERLLAIFFPLKFRIIVTPFRTWTTLLLMLLYYNGSFAFGLTWHQFYYFNRNTTSFGIIGSSTVINRQKNKALLDALETVLIVTTGILPLSIVISWSVIISFKVARAARQRKTMTSSSSSSSSVATRSVANSRTTRTLLTVCVVYSITGSFHYIIDEIFTLTISENVEVQLFQALKKLSICINSACNFLIYVTTNKDFRMFLRRSLFKGMNGAKSDGKARKMAVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0K3</accession>
    <name>A0ABM0K0K3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101854661 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105926.1">
        <property type="nucleotide sequence ID" value="XM_005105869.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854661"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045547589" evidence="3">
        <location>
            <begin position="28"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105926.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="42022" checksum="53A03AB3EDF1249E" modified="2025-10-08" version="1">MTFDLPLHPVLVCGCLLLSLLSATVSAEPVSFCLIDKGPDELGNVTLTCPPDETIVFDEALLGTSQWGSCLITTDDCVEKTKIFDECDGLNNCTRLFKTFSSKCERTSTVLILSYSCAPSLVAIVKTTPPVSAIVTSRPTLSGVEDGGSYGSEGDPQPGNRDDGSDDEDIGLIIGCAVAAVVTIIMLLIAIIMVIRRLLQYYSTDKPDDQSKIVICMNSVCVKMDKLPCFSPSSSSSGGGQGHMKTTGSESGSDTELNKLSSAGPRVAPVGEECNLSAADRSRFETCPTAPPLEESRDNRHLTATSADVEAQRHLGGPAVNVNVVASGSQVSKNNAAESKNCPDKMSSWRKKGINNGSSSCDSKNNNNISPCGQEGNVSKFVPKYDAVAIPNTESGTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1Y1</accession>
    <name>A0ABM0K1Y1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">BRISC and BRCA1-A complex member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101863213</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
        <text evidence="15">Localizes at sites of DNA damage at double-strand breaks (DSBs).</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the BABAM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106824.1">
        <property type="nucleotide sequence ID" value="XM_005106767.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863213"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23664">
        <property type="entry name" value="BRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010358">
        <property type="entry name" value="BRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15189">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15189:SF7">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06113">
        <property type="entry name" value="BRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="13 15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 15" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005106824.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="44109" checksum="0564B3B37D0007A8" modified="2025-10-08" version="1">MVTTGFDLLQSFDPRIQPYLECLLQDNSKITLTGDFLEITNPFSGVLTSVRKNETKYDRFKLRIPYANQVLTWEIIFDVTNVKEPPDIIFDADDDNFHPPMERINSLVCWDWRNKESLAALISELLELYKEYQLERVGQNKTLQRHFTSLMSQNVEAMQIIVNRAERGLGTVNVVAKLDVDFSELPPYLIQENPGVDMAALHVCFPYPESTNIQSQLYLSPAVENAFGGSGSLRIPVFQPGILLGEYFLNMKQLLKKQIKVISEGLEKRKDYIAAFLAHFGRSVLEYDAQHFSKIVLLLEWNDFFFTFTAELPLYFPVEHPTFILKSVYHYQNRQPYFERYTDFPYSPRWSGMEMARRASAFILDQIRSFQRASVNNSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K290</accession>
    <name>A0ABM0K290_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian ependymin-related protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107025.2">
        <property type="nucleotide sequence ID" value="XM_005106968.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849876"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00317">
        <property type="entry name" value="EPENDYMIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045748473" evidence="1">
        <location>
            <begin position="16"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107025.2"/>
        </source>
    </evidence>
    <sequence length="190" mass="21292" checksum="CB2B8AB15F567D53" modified="2025-10-08" version="1">MYLALCLLLAVGALAQVPTTCPGPKQFEGRFQRYDRERRFHVQGAMAYDETSKRIKEFEDESTSGNRTVYVKLKLYMENKEYILDLKTRKCNVTVPRHPFHPYGVPPGSNFQADAVVGAAGVPGESVTVANFAYKMENATFFVSVSEPHCFPISHAYFSQEGLEVTNFFDGQEGISDPDAFQIPKECTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K387</accession>
    <name>A0ABM0K387_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">EH domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101858059</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005107738.1">
        <property type="nucleotide sequence ID" value="XM_005107681.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858059"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="55"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="12">
        <location>
            <begin position="449"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005107738.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62494" checksum="B83C86C6C3F842DB" modified="2025-10-08" version="1">MMRWMTDESKRKKEPEVFNNVVEGLKKIYKNKLMPLEETYRFHDFHSPPLDDPDFDAKPMILLIGQYSTGKTTFIRYLLEQDFPGIRIGPEPTTDRFISVMYSDQEGVVPGNALVVDPKKQFRPLTKFGNAFLNRFQCSHMNNPVLDSITIVDTPGILSGEKQRVDRGYDFAGVLEWFAERVDRIILLFDAHKLDISDEFRRAIEAIKGHDDKIRIVLNKADMVDHQQLMRVYGALMWSLGKVLSTPEVARVYLGSFWDQPLQFDMNRRLFELEEQDLFRDLQMLPRNAALRKLNDLIKRARLAKVHAFIISQLKKEMPSMFGKDSKKKELINKLPEIFAQLQREHQISPGDFPNCKRMQEQLQHQDFTKFHQLKPNLLKVVDSMLANDIAKLMQMIPTEDMERAESEQSNGNIHGGAFEGYTESPFGVGRGEGADAGRGEAEWIVEGQKYEYDDSFSKLNPVNGKISGAAAKSEMVKSKLPNTVLSKIWKLADIDRDGQLDADEWALANHLIKIKLDGHDLPNTLPDHLIPPSKREGFADVSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6E1</accession>
    <name>A0ABM0K6E1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alanine--glyoxylate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005109815.1">
        <property type="nucleotide sequence ID" value="XM_005109758.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846693"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06451">
        <property type="entry name" value="AGAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF40">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="7">
        <location>
            <begin position="99"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005109815.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="48434" checksum="9CE0126082D25D9E" modified="2025-10-08" version="1">MALASSSRKVVDCVVSQARRSIARSGCRCRVVSSTHVPPSQYTAAVMAAFSSSARHEGPAVSSPPQSLLKPMDVPKKLLMGPGPSNCPPRVLAAGALPMIGHLHPEFLKIMDEVKEGIQYAFQTKNEWTFAISGTGHAAMEASVANILEPGDVALVCQNGIWGQRLADMVDRNGSTAAVIQCPMGEVFSLEQIEKGLQEHKPAMVFITYGESSGGTAQPLEGLGELCHKYNALLLVDSVAILGGYPLYMDAWDIDILYAGSQKVLCSPPGTSPISFSQRARDKIASRKTRVRSFYFDAKELANYWGCDEHPRRYHHTAQVSTVFALREGLARLAEETLEKSWKDHRECAELLYEGLEKLGLEPWVKNKDIRNPCVTAIRIPEGVDWKSVVDYAMQNYKIEIAGGLGDLGGKVWRIGILGYNCTPENVKLTLKVFGEGLANARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K865</accession>
    <name>A0ABM0K865_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101855986</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005111084.2">
        <property type="nucleotide sequence ID" value="XM_005111027.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855986"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="250"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005111084.2"/>
        </source>
    </evidence>
    <sequence length="418" mass="48101" checksum="4D21027C69BAE344" modified="2025-10-08" version="1">MKLFGCLLQNLSKMRRSTAVNTQWLDYYSQFHPSPVSIQQFLDFGSKDGSSRESYTFLQKELPVRLANIMKEINLLPDTLLTMPSVKLVMSWYEQSFKELIEFENKDCQNHRFMENFTSTLVHIRNRHSNVVETMAQGVIELKESHGIDSNTENRIQYFLDRFYMSRISIRMLINQHTLLFGKKEKNNDPRHIGCIDPSCNVSLVVQDAYENARFLCEQYYLAAPELDIVSRNNAESECESDPIQIVYVPSHLYHMLFELFKNAMRAAVEYHSEESVPPLKVMIVKGQEDLSIKVADQGGGIPRSKLDLLFQYMYSTAPQPARSDIATAPLAGYGYGLPLSRLYARYFQGDIVLNSFEGYGTDAIIYLKVLSNEANEMLPVYNKTASRVYHTDIPVNDWSSPWQTNQRSVSSFAKMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9Y8</accession>
    <name>A0ABM0K9Y8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112472.1">
        <property type="nucleotide sequence ID" value="XM_005112415.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849816"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02986">
        <property type="entry name" value="DLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF4">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112472.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16996" checksum="5F0047CB16E469BC" modified="2025-10-08" version="1">MSFLLPNLCSKKEVDEVIRNTEDLVLVLRFGRDTDSSCLRLDDILSKTSNDLANMAAIYLVDIDKVPVYTQYFDISLIPSTIFFFNGQHMKVDWGSPDHTKFVGSFKTKQDFVDVVEVIYRGAMKGKVMVTSPLDPKDIPKYSLLYKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAJ2</accession>
    <name>A0ABM0KAJ2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101845822</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 18"/>
    <dbReference type="RefSeq" id="XP_005112900.2">
        <property type="nucleotide sequence ID" value="XM_005112843.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845822"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="20">
        <location>
            <begin position="115"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="451"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_005112900.2"/>
        </source>
    </evidence>
    <sequence length="560" mass="63468" checksum="3B62851284499A3A" modified="2025-10-08" version="1">MIGGSEVFPRGANMSVPEVRGQFDDVDASDSEGSLDEGRMSPGLSQYVKQSGGDDIENYEEDFDDDDEDYDADPKNYSNFSKDFALQAPKSGQQQLHTQINKISVGEYKREKRRDKSQRATVEQVLDPRTRMILYRMLSKGLLAEVNGAISTGKEANVYHATARDGTDRAIKIYKTSILIFKDRDRYVSGEFRFRHGYCKSNPRKMVRLWAEKEMRNLARMHKVGIPCPEPILLKNNVLLMTFIGEDGVAAPLLKDATLVEWKARELYLDVILMVRRLYHQCRLIHGDLSEFNMLYCKGQAFIIDVSQSVEHDHPHAMEFLRKDLTNVTEFFRKRNVPTMTIKELFEFVTDSSITEGNIDAYLDAAMEVAAQRSLAEVSEQEKIDEEVFKRAFIPRTLEEVVDIERDVRRSQTQEGGQVLYHTVTGLRPDLSGPSQVPDLIEKLAAVVGAEDEEGGEMDEGGEGGGLRLPTLEDNGDDSEDEDKDSALGDAGSEQEGEGSDSEDDEDKKKGHPTRERNETTEEKKERKKQVKDSQKEKRQTKIPKHVKKRQVKVGSSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB49</accession>
    <name>A0ABM0KB49_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable serine/threonine-protein kinase CCRP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113356.2">
        <property type="nucleotide sequence ID" value="XM_005113299.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860551"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005113356.2"/>
        </source>
    </evidence>
    <sequence length="258" mass="28567" checksum="DC9CAB97D8ECB826" modified="2025-10-08" version="1">MGYHPTDLSHGLLDVTYSEAESYTSQLTDVMCYLHGQRIIHGDLKLGNVLLDRAGRVKLCDFGHSQVIPEDTDMPDGWGGTDGYKPPELYHSQVHNAFKMDNYSLGILLWALFFGTAPRNNIDYLKEVDNCSFLKPQHKHCLQRLLSLSPTHRAYIWEIARILKDEDTSERYVSKGPVCSLSSESSSDSAKANQSSPDSGSSVTERPESAAVSNQFLAPPPPHPHATSCYLLPQTAYPDSGDVPTSLAPTWPPLHQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVM6</accession>
    <name>A0ABM0ZVM6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein CXorf65 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935481.1">
        <property type="nucleotide sequence ID" value="XM_013080027.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857235"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039471">
        <property type="entry name" value="CXorf65-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33887:SF6">
        <property type="entry name" value="CIDE-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33887">
        <property type="entry name" value="PB1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15874">
        <property type="entry name" value="Il2rg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935481.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19817" checksum="21ACCA893968B0EE" modified="2025-10-08" version="1">MSREPSGLMSDPSFVVIKYGDDQEALINPFCSTYIFLDWIRRICNCGNDISIDLVDLEGQLRHLPVSTDEYATEYVTSRETYVVIRVERQGDYGPNKYISLLNDLDKLNPELLVKLNNLSRPGTRSSKRDRGKKTPSRSSRNSNNNSNNNSNSKHETTRRPTSSERNGRSKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVQ8</accession>
    <name>A0ABM0ZVQ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein DDB_G0271670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935531.1">
        <property type="nucleotide sequence ID" value="XM_013080077.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863553"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045428552" evidence="3">
        <location>
            <begin position="27"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012935531.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="40138" checksum="796CCC1F29CB191F" modified="2025-10-08" version="1">MDFTWSTSLHLNLICIFTVCCGFALATVCPRPLNSHVSEGEGDVIPDHGDLVGSETAGSLKKDYSVCSGGCCQYAVDGCCRESEKASMAYGATFLGMTLLVGVAVALICRKARNRRCCASGTQNRSRTQSETDSPPPYSACVNMTSRRENSEEPTSRITSHDNSTPRDDLSPTLTLQSTTLQTVRSGVRHPHHLPAPPAYKDIFKDENSEHLFEVAIVRRAGEVRFTTHTQLLSELKSQEQESSESGLSPVTSLSPDSEMGEAENSTVNNCVPRNTPLTDASSVACYDNAGFEEHRTDECCKSDRGGDGNNNTNGNDGRGIIIASSNRSSSTTTTTSSSSSNRSCYNSGSIHSSTINGNNSSDDIVHRSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX48</accession>
    <name>A0ABM0ZX48_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mesenchyme-specific cell surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936330.1">
        <property type="nucleotide sequence ID" value="XM_013080876.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862105"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055188">
        <property type="entry name" value="Choice_anch_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052956">
        <property type="entry name" value="Mesenchyme-surface_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928:SF1">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22494">
        <property type="entry name" value="choice_anch_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Choice-of-anchor I" evidence="2">
        <location>
            <begin position="22"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012936330.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="48562" checksum="5C783C4B57FB7A5C" modified="2025-10-08" version="1">MLQARFDCNTVVIALEGGGYKDSSGAFHDPEGAVVTVKFPNGPRGSAQPVVNTLDFRKYNQRFDTLEPSGVRFVYRDNNSFSNDVEPEFVTLDEKSHTAYVCLQENNAIAVVDLTSENIEHVYGLGFKHWGHFDASNKDQGIQISYWPIRAWYQPDAVLFYTFQGRRLIFSANEGDAKQYSDFDEIERGKKLKNVSSTVPKFVRASLQDDALLGRLKFSSVDGKDEQGNYQHLYTYGGRSFSVWDADQGMTQIYDSGSHIEESTALHCPHLFNMDGNDEQPDSRSDDKGPEPESLALAEVRGRLYVFVGNERPGTISVYSFGSDLTKPRFETIFCDGIPDDSRTPDQRFADRDLFAVDPEDIQYLSEEESPAPYPVLLVAGTVSGTVSIVRVNITDEPGDGDPKPPNNGNTYAAGSVWVLAASLLVTWFKTREISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXC8</accession>
    <name>A0ABM0ZXC8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">omega-amidase</fullName>
            <ecNumber evidence="3">3.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nitrilase homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101864375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:32963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16769"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:32964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxosuccinamate + H2O = oxaloacetate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59412"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57735"/>
            <dbReference type="EC" id="3.5.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:59413"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.5.1.3" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012936446.1">
        <property type="nucleotide sequence ID" value="XM_013080992.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864375"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012936446.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31627" checksum="8CCBC30CCCBF6D17" modified="2025-10-08" version="1">MMSKFKIAMVQMAVGTSKPGNLARAAALIKEASSAGAKIITLPECFNSPYGTKYFPEYAEPIPGPSSEAMAAAAKENKVFLVAGSIPEKCGDKIYNSSAIFNPEGEMVAMHRKVHLFDIDIPGKIRMQESEILSPGKQMTMFRTPYCQVGVAICYDIRFAELAQIMTQKGCHLLLYPGAFNMTTGPAHWELLQRGRALDNQVYVATASPARDTQASYTAWGHSSVVNPWGEVISTTDEKESIVYADIDLERMEEIRNQVPLRNQRRHDLYRVSEPAEEDRREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY49</accession>
    <name>A0ABM0ZY49_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear distribution protein nudE homolog 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101852234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936907.1">
        <property type="nucleotide sequence ID" value="XM_013081453.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852234"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="10">
        <location>
            <begin position="133"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="14"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012936907.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36427" checksum="0D7102238A9E9B14" modified="2025-10-08" version="1">MDAGRKFASKDQEADHWRNLAQQYKQELEETKEELEDYQISSRELEQELETQLKQEEKKNKELNLANDRLQNECDSLRDKLQKLQGDSHKRVTELEDNLAKVEAYKNELAKYVRELEQANDDLERAKRATVVSLEDFEHRLNEAIERNAFLESELDEKGTLVDTVQRLKDEARDLKSEIDVKKHQDVVMKTSSESLPGVSAGQPMQDSGYAAQGTTPTTPTTPMGRIPPSGITNNSTGGTPLTPSARISALNIVGDLLRKVGALESKLATCRNFVKDDSRAKTGTSPLNSPRSEPFISSGTRSKRTKRLNRGSSLPVQQGVKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZL7</accession>
    <name>A0ABM0ZZL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106011731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106011731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937806.1">
        <property type="nucleotide sequence ID" value="XM_013082352.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011731"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508:SF2">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="219"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="400"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012937806.1"/>
        </source>
    </evidence>
    <sequence length="821" mass="91791" checksum="3108389C7CD89EAC" modified="2025-10-08" version="1">MSGVGDDKENEDSNVQNTAALVNGQNGKLETWLETAVTKEALASGANEVDLGPNEVLSVSADKMGKTVTGDGGEVAHDENVEEKKEVVDNDVNSQDQDGEKMDSQEKEEAMDVSQVKSKEDSNAVPDLDNACPDEQCEDEAAPKAMSIEIKDKSSKQPDDVNHFDSVSNIKSHPDKEKKDTKKDVKIMDENKPEKSTLNQSSSQANQSRQAQTSRLKKMKKGIFVSYSPDAGFLERRFVVETVRQLKENNLAEDIWFDKDEKNTDNPCWFSMRMEAVEKCRAAILIFSDSYFTCPVSLYEGKALIERLAMDSQALKIFPILYRHPDITDVPKQFCDFLDAAIDLTGEHAKKSAAEKTSVVVGAIMEDLEKYATIHSAPLPVSPPDSEFTGEFKKRKICQWSASDLQEWLFNLGIKEFYRQSLAEAMVDGFLLMSLTDHDMVAHLGIESRVVRKKIMQQILHTLDREHKLPDNWHLRARAQRAKPDVVYIIYDPADVRLAQNLKADLKAKNMQVIHHDTVKLGRSKEEFLQINGSHLATASHVIVLLTDAAAGSPFIFHEVLFADWLGKKVVTAMFRNIWPGLRSALKAVLGDCPAVDFESKMYPESLDVLEHQIKPLRRVPGVVLEQAYLNKMADGLKPLEALANSRGGAVSASPPSEEEAQVFISYQWDMQTKVDEIQQLLERAGFPCWADIAMGGPPRGSSSRSNRSSVAFTHVDSASETLAGQIQRTMKACHVVVCCITPKYLQSDNCAKDLTLADAFHKPIIPLLLRYAPAESAPNYVRRILLRYSYIDLSNERLYKQNINVLLERVRKAISSAMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZS6</accession>
    <name>A0ABM0ZZS6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dynein regulatory complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101850648</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937903.1">
        <property type="nucleotide sequence ID" value="XM_013082449.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850648"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033551">
        <property type="entry name" value="DRC7/lobo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056292">
        <property type="entry name" value="DRC7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056291">
        <property type="entry name" value="MORN_DRC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249:SF2">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24671">
        <property type="entry name" value="DRC7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24667">
        <property type="entry name" value="MORN_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="11">
        <location>
            <begin position="164"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex subunit 7 MORN" evidence="12">
        <location>
            <begin position="458"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex subunit 7 C-terminal" evidence="13">
        <location>
            <begin position="792"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012937903.1"/>
        </source>
    </evidence>
    <sequence length="899" mass="104862" checksum="2D3C44DDFAEBFD36" modified="2025-10-08" version="1">MAEAAETSASTAHEDMEKEEDGEEENRDGHSNVSSGEKEGEEGTEEEEDEKKDDEEGDDGSEGEDGAESLKEELNKIQVESPKPTEPVFDPSKFPPSYKDNNPKEQKAIRLCKMAIKQFRDLYFDRRPLFLKPLNEFGVQKLVCTTISPTQLPYKDLLDWPDVAEFVAGYLSYDPLQPPHMLPEHLYAPQTVLERQRGHCFEYSTLLCSMLIGSGYDAYVVSGYASREVCNIDLTYTPCPLIEQDQKVYTQPASLNIRRYTVRPPRKLASVYMLRMKRKEDAIKKKFLDEKIELEEKERALKEAPPPDPLKGWRVHSWVMVLKGLRDVTETFFIEPTTGVSHPTDWGQYLGIESIWNHLNYYINCHREAVNTKVPVTKLTVPAPMLLPVGKMNFDIGDSCYWDFLFNWQNLHRKKTDEELREEQRKGDNCTEETFFDLPLSWTQPLYVHRDDYDMKFPTGKKTIKYKGAVVESYAYGLNPDGMVRKLWVYHDVEGKILRYSKETFASRADLLETRYLEHPTTRVVEQFATGRADYLRVHDYYAQTPGPQSKRTLVFEKGGRRDGLQRKEEGPDFMKLFYGEFREDKKYYKEVRFGPLGKVRESSASKDARPIEVIEECFRRNPEVPANENIARARFSVLSDEMDVEYHVEKDRISFSTRHFTKPPLWWDETQVLTWSPFLHWNYEVDQCVRPKCELELYNLLISLMAMEAKTREQTRAAERETASVLRQREKEAAQPVLLKNYSQAHRVPATREARLDERAREKAARILKRSDILRDYLEPNIQRLGLGKVTNKKQASKVRDDCLGDLKECLLTQINMMKEDFEKEKALIVTLQTGFHKNFILLSQEEEEKFRVEVSQHMFVAHILERRINTFKEYAPMKYQALCDTLARDPRLEPYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZY0</accession>
    <name>A0ABM0ZZY0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase MINDY</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101845326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 8">Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="RefSeq" id="XP_012938002.1">
        <property type="nucleotide sequence ID" value="XM_013082548.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845326"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Deubiquitinating enzyme MINDY-3/4 conserved" evidence="10">
        <location>
            <begin position="18"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012938002.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51076" checksum="265357CD8CED8CA2" modified="2025-10-08" version="1">MASFNFQIFEKTSLEDIKLLLWGASLKEEVFSRWSQGFIFSESSPTSLIQFEGGPCAVIAPVQAFLVKCALFGHGMPNMDALTSVSSEGASNLLLEALVEILSQMNSSAYVVVSFDEKSVNVKETSSNQQAEDEMGGPSKSLQSEESAQIKTDASLAKSDLSFHANLRYCCCNDLTDLRTLLKQMLPQLHSCYGVLLYLYSILCTKGIEQIKNEVEDPSEPLIDGIYGHGSQSLINLLLTSHATSNVWDNDKEISGLKLRGLLQQPTIGFLTLLEHMRYCEVGWYYKNPKFPVWLLGSETHLTVLFSTTESLVVKETPGRNANLIFAQFDPEGNGFISSSLLDDVMRALDLVSEKEYVDIMRIKLDAEELGIITRNSFMEEFFPEEPTEQVQSFSVYHHNALPQSCTEGKVMFVEGRAKLADEIDTQFICDTSPMALCLQTKWPSIEVTWSIGAPPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0H8</accession>
    <name>A0ABM1A0H8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Orexin receptor type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101864067</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938336.1">
        <property type="nucleotide sequence ID" value="XM_013082882.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864067"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045034926" evidence="12">
        <location>
            <begin position="26"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="129"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012938336.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="61372" checksum="09A34458C9AA6595" modified="2025-10-08" version="1">MAQGYQGTTLLPLLMARVLEAKASGGDPTEPSHHVPDTRHRHHHHNPRPHAHIVKPTQEDGMTTHNSSFLSSITTISINNVSDSTTTDNNTGDYYDYYQDDGLTPEATAAIHWIFIILSAAVLVVGLMGNALVWFAVWRNPRMRSATNIFLVNLAVADFLVILICLPPTMTEDITGIWYLGPEMCKLVKCLQKVSVFVSVLTLTAIALERWMAICEPLMFRQTSVRAKRAIAVVWLLSLSSAVPDAISLDIIPVSETARMCGPTWSEEAETFHLWAIFVIFYLVPLCIMTFTYVKVALCLWRSNFTDDDDGRTSVPRAQMILRRKKAKMLIMVVAMFAVCYLPVYVLFIFRYTGILDYFPPESIKPLFLSSHWLCYFNSALNPTIYNFMSCNFRREFRIACHICCRRSSTHSSIYEAMRLREMSKRHLRNDNRTSGHATNDNSCTLQTQTLLLGPSASSYSLLSGQRHDSDPNLSMAPPACTGCNNSGGGASCSRNCGGGYSGCSNANGGLYPNGGQGNDATSPVQERQRSPGGSRKMRVVVLQRNHKAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0P5</accession>
    <name>A0ABM1A0P5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mushroom body large-type Kenyon cell-specific protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938446.1">
        <property type="nucleotide sequence ID" value="XM_013082992.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849930"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046728718" evidence="2">
        <location>
            <begin position="23"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012938446.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25586" checksum="AD4F24E8769F2B54" modified="2025-10-08" version="1">MASLRHTWVISVLALACTVAIGSPVGEPKESVPSAISEPAQEASVSTQETVPGADKPEVPETPPGDAVEAPKIEPTQTDEAVVNSPQTAESYAKEVLRQFFEELKKHPKLVEQILNHETYKEISALKAIDPNLAIRSPEVVNPSPLWQYMPPFTPGQSQVEQKVPQRQLRQQLPLQQQQQQQQQPQQQQQPQQQQLLQQQQTNPQQVQLQQQPQPIQNFGSAFLDFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1Q2</accession>
    <name>A0ABM1A1Q2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859790</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939043.1">
        <property type="nucleotide sequence ID" value="XM_013083589.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859790"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058727">
        <property type="entry name" value="Helical_Vwde"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26129">
        <property type="entry name" value="Vwde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1 2">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939043.1"/>
        </source>
    </evidence>
    <sequence length="680" mass="74539" checksum="340D8C4A838FD250" modified="2025-10-08" version="1">MYANPDEDFEIQGKTWPCQLTPTMSCLCALTVRSHRDVIRASICHSLMVPENFHDVSKPERLQMLWANTRLTFKIPNHGLRNGTEVFHDPDLNQALISFPGGERIEMERRGISLNVVLNLPPGHARSASAGGVCGNMAKNFTHHQLTNPDGSQTTCQKYTGQKDCLNTNFNSAWKQPKGKSLFTNPPAYAKPYTPKSLCACSDDASKATKAINCGADGNQKPKMKDCVGGCKDITNGLPPGLFGGTWKRAVPGLFGGTPGQISVDFDVNEFVDKSPNSSQSAPQATAEERHNATHLCTDVLGKSVLLDHCGPETRRIMDSIMEDCVTDVLTSGDHEFAKTALAALNNLCRDKIRRNPKNYKPNKDGVLEILPEVSTEICSQTCIEHGHCEKGKCVCDPGYRGIHCSKPEFLPTGPVFLWPGSGASPHSTTGMINIDHTDTRLSATCDVAMHSCNPVRLVLADRVHSAKCSVRIEGKDVSVTKSAKIGFSQEVDCTIPEFYVGKTLQGSPSINITLTVTIDGGRSQHTIYYFVYDSRCLTFAPNGQKTIAPDVCVIDSTCFPDGARNAHVVDRACVVTESQTQWRESINVPLRPEDVTLNLEAPFTRSRLACHVGQSTVDQHVLWYLNGIQIRDVTLQPGQSKAEFDMTSVKSDRAVIIQCKSPDPYTPHILRVSKEFTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A201</accession>
    <name>A0ABM1A201_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Frizzled-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101845776</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939205.1">
        <property type="nucleotide sequence ID" value="XM_013083751.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845776"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15909">
        <property type="entry name" value="7tmF_FZD4_9_10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF99">
        <property type="entry name" value="FRIZZLED-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046017864" evidence="12">
        <location>
            <begin position="23"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="13">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="266"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012939205.1"/>
        </source>
    </evidence>
    <sequence length="633" mass="71252" checksum="A0EF3ED58A399286" modified="2025-10-08" version="1">MSSRYLLLLLAVVLCGLGAVDSASALRLDGRYPRCEPITIKMCKDMRYNMTQMPNLAGQENQIEAEARIKDFIPLVQTGCSRLLQFFLCSLYAPMCTELVDETLIIPACRSMCLQVKAKCEPLLRTFNFDWPPMLACDKLPEKSDPRNDLCMAAPNVTDEPEYGAGTLSGGHFEEFEKKLDKLDGNKNWKKIIKERLNKKGGLIIMNPTTARTRLGGQKFLDKHQPIPDPCPPRFVHVDNIPRSNNTCAPRCDVDVLFREEDKNFAEIWMIVWASLCCFSTLLTVTTFIIDTTRFKYPERPIIFLSVCYFIQSAAYIIRVATGPESVSCDTARDGRPFLIQEGLDSTWCIIIFLLLYFFGMASAVWWVVLTITWFLAAGRKWGQEAIEALSSYFHLAAWAIPAAKTIVILTMRRVDGDELTGLCYVGNQDPDALTGFVLVPLCIYLVAGFAFILAGFAAMFRIRKDLKEDGVSANIRKLEKLMAKIGVFSVLYTVPATCVIGCHFYERVNFLRWRRRAMSLPCPLDTSNKLSPPVVDPDCPLEQSIPTVEVYMLKLFMSLVIGITSGMWIWSGKSLSSWKNFCSRRFTRRKTNNFNAEYHPAPVIMMKNSHQGNSSKIGSNSSGSAKVIASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4W5</accession>
    <name>A0ABM1A4W5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrinogen C domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940890.1">
        <property type="nucleotide sequence ID" value="XM_013085436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860267"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF254">
        <property type="entry name" value="TENASCIN-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="319"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940890.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59240" checksum="9D266A5E0A589AC6" modified="2025-10-08" version="1">MRSFGVNPLMIAEIGFFNSARRLKVTFPNSRVRSQKTETSRKKYVKIFVNRITSSTSNMDATWIFTNIILVATLIMCSKAWRLNVTSEEIEIGKTAQVSLNCYNPYQQPDISEILLMRIQKKHLSGWSSVAELRDDDVDVRLTAKDVTATGSIVSGANSYMRLSWPLATNDTIGVYRCDVTILNSHGSIGWQKSLPTSITRKSDVTVQILFEIVEENKRQCLQQKHDIKEYVAAAKEENRKNSLKEKQDVLQNMTATLKALEASFESKLERQIEILENVAAALDRNRKEGLQQSQDLLVNVTSIMEDLEVSFERKLSVVKSQLLSQSCASAKGLGPRPVVRLSSGQLVVCDTVTDQGGWIVIQRRVSADVDFFRGWADYKNGFGDLSGIRLLQLSSRSHHQERYELRFDLRFQGKNYYASYDTFSLSGETDNYKIQLSGFSGNVTGDNMSYHNGAEFSTKDRDNDLWHRNCASVHHGAWWYRVCRQVNLNGLWGSTGGPKGLSWRSVTLGSVSFSEMKIRPFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A627</accession>
    <name>A0ABM1A627_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Regucalcin</fullName>
            <ecNumber evidence="8">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101853020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="8"/>
    <dbReference type="RefSeq" id="XP_012941536.1">
        <property type="nucleotide sequence ID" value="XM_013086082.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853020"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008367">
        <property type="entry name" value="Regucalcin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01791">
        <property type="entry name" value="REGUCALCIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="15">
        <location>
            <begin position="14"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012941536.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33287" checksum="9AFC75BE016F0EB9" modified="2025-10-08" version="1">MIKVEALHPDRFQLGEGGYWDTRSDSLLAVDLWDRAVIRYHPSIPQLKRINVDEEPHFAIPRSNGEGLVITQGRSLNFLNEATGKVSPFVSEEKFELSADGLINDGKCDAKGRLWLGTYVAGGSFDEVEKWKPNGALFRISPDGAVSKQADQIVLSNGLDWTTDSRTMLFADSFGLRMYAFDFDLESGELSNRRVFKQWEAGSEEFPDGLCIDADNKAWVAMVSSGRVIQLDLETGKELQSVSLPCKGVTCPNFGGKDLSVLYVTTSATLRLQGWPENPPEAGAIFKVTGLNAKGKAPNMFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A663</accession>
    <name>A0ABM1A663_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Lysosomal aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC101849147</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104863.1">
        <property type="nucleotide sequence ID" value="XM_005104806.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941580.1">
        <property type="nucleotide sequence ID" value="XM_013086126.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941581.1">
        <property type="nucleotide sequence ID" value="XM_013086127.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849147"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021907" evidence="5">
        <location>
            <begin position="20"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005104863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012941580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012941581.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="46360" checksum="D2D49E2A9C333D14" modified="2025-10-08" version="1">MHVLASASVLLLAVSSVYCNLLRIPLHKTKSARQTLAEHQNNVQVLMQKYKATNRVDKTGFEPLTNYLDAQYFGVIGLGTPPQQFKVVFDTGSSNLWVPSKKCKWTDIACLLHNKYDSTKSSTYKANGTDFSIRYGSGSLTGFLSTDTLTVSGLSVKSQTFAEATSQPGITFVAAKFDGILGLGFDTISVDRVVPPFYLMVQQKLVAKPVFSFYLSRDPNATEGGELVFGGSDPSLYEGNFTYVPVTRKGYWQFKMDGMTVGSTKFCSGGCNAIADTGTSLLAGPTAEVEKINALIGATKFVGGEYLVVCANIPKMPNITISVGGRPFVLTPEEYVLKITVMGQSQCLSGFIGLDVPPPAGPLWILGDVFIGPYYTEFDMANARVGFAPTKAAGNRKSAPNGDVVDNTLRYLGFRESRKDVFRMNVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6Z0</accession>
    <name>A0ABM1A6Z0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sperm-tail PG-rich repeat-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942053.1">
        <property type="nucleotide sequence ID" value="XM_013086599.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846448"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF60">
        <property type="entry name" value="SPERM-TAIL PG-RICH REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942053.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="63026" checksum="87DAFB2A0703CD32" modified="2025-10-08" version="1">MYDRAPRDLSFKLGSTPNVVGPGSYDADTVTKTRLRQDGYAPFLSMSSRETFLNVSDQVVAAPGPGHYDVNLLQDGVKGGASLANRSKRFDKNASETPGPGAYQVHKHLETARYAKSAPERGAAGKGLLMTSRIKFHRKPEAPSIPSQGQAYGYEECDDGSLKKQDAPNRDQSIGPAYYNPNVPDGKSTKAYKGVHFGKLSSRRMDFYGKAGPGPGDYDPFISTASKAENANVQSEENFRYESRLPRYHEMITRDEEKKAIPGPGAYETKSTFLAQTPTFNPEGIEIEHPPFLSQAKRFSPVKSNAPGPGAYNDPRGALDSLKRVSGLKRSPFSQTAVRFNPEQQMKRAPGPGAYNISGMGAESMRKAYLEATRKGVFGTTSSRAQPMARKDEPEVPGPAHYQVKEKPFKSKYQQMGSNFASVTTRMKDLELDAPPPGSYDVIKSYEKSQVKPPVAKPRSEAANRKHGSFMSAASRFAPPRDVVVHKPDLENPGPGTYDTPREALGPKGGLMVTRDKRFRHEKEDFPGPGAYELSPLIQDTVLRGTFNHTLNNPVMPAVDAPHAMTNAKHAFLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A779</accession>
    <name>A0ABM1A779_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101856682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942189.1">
        <property type="nucleotide sequence ID" value="XM_013086735.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856682"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08835">
        <property type="entry name" value="ArfGap_ACAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF399">
        <property type="entry name" value="BLOWN FUSE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="95"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012942189.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="62547" checksum="8AF6DB5117FBE18F" modified="2025-10-08" version="1">MEEDLRLCTIRLPSDLDRRFCFEVLSPTRSHILQADSEEDCQTWVKALNASISQAYKDTMHESDKESEEKSSTSSGAESSQGDNSSAQAKPSKEKLRMEQLLVVPGNSNCCDCGAAEPRWASINLGVTLCIECSGIHRSFGVHMSKVRSITLDTWEPENLKVMLELGNEVVNRIYEAKVDESIAARATPECNRVVRESWIRAKYVQKAFIKQLPGVNKGNKLRQWSVRKKTRGSPARLLKKHSLEETSASKDSLSSRGGDSLSPSDSDDLTSGLLEGGAPGARRAVLSVSNMGTRISGSGSVGSSNSGAASYVEGLSRSSSSGHGTSDSGNVTATAATSTVDISTNIVFGEESPLARVAGLNKSLDLESSDESSPDFDEDSVGDGDGSGRGVAMDGDQFHTSWEDMSKLDPNLLLYKASGARNLGVMLEALGNRADPNWVNLEEEGRTPIMKAVQTGSLAACEFLLLNNAKLDRRDKSGRTALHHATILGHTGQVCQFLKRRADVNAKDNQGKTPLDIALETENANADIVTLLRLAKLTEEMKESEGYMGNPGDDTFQDVCRDFTNMASNNPEKLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8K9</accession>
    <name>A0ABM1A8K9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="4 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101862677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="4 11"/>
    <dbReference type="RefSeq" id="XP_012942912.1">
        <property type="nucleotide sequence ID" value="XM_013087458.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862677"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047395999" description="Alkaline phosphatase" evidence="12">
        <location>
            <begin position="31"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012942912.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="57200" checksum="2007E7BFD6A3C9E4" modified="2025-10-08" version="1">MAPRGKMIADFWTVCTTVLCLLLCIRTVVTDEENSEYWRQVGRYALRRAITVARHQNKNLARNIVLFIGDGMGISTVTAARIRAGQMNNRSGEENLLFFERFPHTGLMKTYNVDAQVPDSGGAGTAIMTGVKANTGVIGCDARVSKGNCSAYNEDSKLRTILHAFTDKGLSTGIVSNSRVTHATPASAYAHTPNRGWEGDVDLLSSGPECRGVDDIAKQLVMNNADIKVILGGGRRYFLDNTTADPETGEIDPYQRRDGLNLIQEWEKDKENRGATHSYVWNKTQFDQLDLDNTDYLLGLFSPSHMDIFDEETANNETELSLADMTEAALKVLEKDNRGYFLMVEGARIDWGHHVNSAYTAIHETIAMDEAVERAFLRTSRRDTLILVTADHSHAFSIQGYAPRGHDILGVTAPDSNSVPLDGLPYTTLGYTNGPFSGRHDVTGVETDSPDYRQPGCVPLGVETHAGEDVAAYAVGPMAHLLHGTQEQNYLYHIMEYAACVGYSERYCSNSYTHDRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8M6</accession>
    <name>A0ABM1A8M6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clumping factor A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942935.1">
        <property type="nucleotide sequence ID" value="XM_013087481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855134"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942935.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="18002" checksum="02EE58BB6D4E2DB8" modified="2025-10-08" version="1">MTVTVTVTVMVTVTVTVTMTMTLTVTVTMTVVVTVTVTVTVTYDGDSDSGGDSDGDSDSDGDGDSDSGCDSDGDSDGDSNDDSDRDGDSDSGCDSDGDSDRDGDSDSGCDSDGDSDSNNDSGSDCDSDGDSDSDGDSNDDNDSDESFHTGHQELFVGINSDSVDSSTFQIFLKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8Z6</accession>
    <name>A0ABM1A8Z6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013024</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943109.1">
        <property type="nucleotide sequence ID" value="XM_013087655.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013024"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943109.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26726" checksum="2FB315D194B776DA" modified="2025-10-08" version="1">MSQNMTTSPLKQNHFRVQLTPPVPWINPAGWSAHSVPVPSFSDIGHQLAENMAPEPADCQPSCKRRRMETEPSPNGAESSVSGFGLRPFSSSQTRNVGDVSGGYDHVSQMPMETQLWFRLREQALREKRDNLLHYGTVDIGTVDWVKVQAVSAPVFSLVSAFVANFQEEFYTNRFSLEERLVLKYLCTECKIETTDQLCNNDSVVTLRKTSETLFPTDQAFQRVLMTLQQPQTMVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9K4</accession>
    <name>A0ABM1A9K4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein yellow</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943431.1">
        <property type="nucleotide sequence ID" value="XM_013087977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855372"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046174993" evidence="4">
        <location>
            <begin position="28"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012943431.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="49987" checksum="7839C2A894B3BACB" modified="2025-10-08" version="1">MTRTGTFSCYFIMAALVLLGPACMTSAVQFGDASLVYQWSALDFVWTSEQVKEEFIKNGSFIVDKNLLAGIKVYKSQVYLTIPRWRTLTGFPVTLAKVVEVQGQHKLSPYPDWASQTIGDCQALQYIQSMEIDPNTGHMYVIDTGRIGLASPNVQPQNLCPAKIVVYDLNTDQQTASYEIPADVVSRDKNFMNDIVLDYVDGKVRYAYISDVAEAKLHIYDFETKTGRNLVDEASMQAEADGSIITINDVNYTFAAGIDGIAMSPDFDYVYYCPLGGYNLYQVPTSTLRNGGTSGIRLLGRKVSQSDGLVYSSKRLYYGGLGTNAVYFWNSEKDTTDQNVDIGQANLTTQTQLVQNDETMQWPDTFAIDEEGWLWFVSNRLHLFSTGTMNLTGSEVNMRVWKVFINETSYLHGAHTRTASRGVGLTTAMTAIYVTSVCVVVSVVCRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA31</accession>
    <name>A0ABM1AA31_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ homolog subfamily C member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101845498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943726.1">
        <property type="nucleotide sequence ID" value="XM_013088272.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845498"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="411"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012943726.1"/>
        </source>
    </evidence>
    <sequence length="564" mass="64303" checksum="6F39B67096B9D5AA" modified="2025-10-08" version="1">MAASLEEDDDILKSDYYALLNVARDASLEEINNAFRHLSKIYHPDKHVNPDRKKKAEEIFNKLRKAHDVLRDKRTRAVYDMFGEKGLEQGDMEIVARTKTPAEIIAEYERIQKEREERRLQQRTNPRGSITVSVNATDLFEADYEEDDLMDYEPSRTVEISSMSISQSVECPLTLKDTLVVGGNLDTRNGIGQGMFSIMWRRLISTKGWAELDVHLGSAAAFGVTGFRQISQRCYFRFGGRIEVTQLGYRPSATFMLAYQFDRNIQGRLTYNLSRPSSINTTVVYSNEQHHLSTSAQLGVRSSHLSLTYVRTFLEHNTKVRGALKLSTVGSVVECSVEKKITDFSHVGGTLLVGVPLGVHLKIKLLRGQQSFFFPIYLSEGLSPSAIVYGAVVPLVSYFVIRKLIVNPFLKQQKQREMEKQKEEYAERLAQRKEEASKAVELMKATYERCVEMEEKKSGLVVMKALYGKLLSSDDGEILEHTCIDVTIPIQALVKDSKLILPETLSKSGLPGFYDPFIGEEKKLYIRYKFRSRLHQVFLSDTEPIRLPQQKHLMQVEEPHVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACB7</accession>
    <name>A0ABM1ACB7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013538</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944991.1">
        <property type="nucleotide sequence ID" value="XM_013089537.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013538"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047198353" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944991.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15587" checksum="E91ECC2002D62002" modified="2025-10-08" version="1">MNVLAIFSTLMAVALGFHTGGHSGGHGGFSDVIKRPVVSRRDVAAVTQDDLYDVIKEVVAQAHAGTTSEDLTQAAVKVIAQVDNLLAADNSPVDPSDVRNLIEVSSAQFGAQTAVSAIFDGEYAMFIRGFSLQFSGRWCTHYMLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACD4</accession>
    <name>A0ABM1ACD4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen alpha-6(VI) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC100533530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2010" name="Front. Aging Neurosci." volume="2" first="6" last="6">
            <title>Do different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Kohn A.B."/>
            </authorList>
            <dbReference type="PubMed" id="20725513"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945016.1">
        <property type="nucleotide sequence ID" value="XM_013089562.2"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF87">
        <property type="entry name" value="COLLAGEN ALPHA-1(VI) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046493130" evidence="1">
        <location>
            <begin position="18"/>
            <end position="409"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945016.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="44417" checksum="837FDD96FEEBE900" modified="2025-10-08" version="1">MIKLLCVFIVALGAINASVVKRETIHDKGTHLLVCEQEPIELGIVLDSSVSIDRKDFKKGKEFLQDFLQQFEIGGGDRDVRVSIITFGKGIYPEDGFNLTKYTDKDELIAAIGNIPHRLGRYTSTGEGIEYMATAQLASQFTRSWAERVGLVITDGNSQESAKTKEAARQARESGITMFAIGVGNVKDQELVNIAGDASRVFKVDSYDELENIKQTLAHQTCIRQLKTTTPPPQTVCGEANPADIYFVFSPAELGLEGTSWATSLIGSLIKQEQMEEGFRFGVVSGSCPDDEGFNLDEYSNVSDIETRLSTYAASRMSALVDRVSGNDFYGTTGGRSGAQDVAVLVSSGGKRSRRLQAEVDRLRNEGVEVFVADISGSGISFEGATTLTGATYKDVALNLVTQLCPTRN</sequence>
</entry>
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    <accession>A0ABM1ACN7</accession>
    <name>A0ABM1ACN7_APLCA</name>
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        <submittedName>
            <fullName evidence="9">Protein hairy</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">LOC101858370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945161.1">
        <property type="nucleotide sequence ID" value="XM_013089707.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858370"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11410">
        <property type="entry name" value="bHLH_O_HES"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="7">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012945161.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="41853" checksum="637B1A8420BEDB07" modified="2025-10-08" version="1">MGSPAVAVSPRKSPSSIRRANKPLVEKKRRARINGCLGQLKTLILTAMKTEGAQVSRLEKADILEMTVKYLRHVQSQSVRAVVKLEPEVAAKFQAGYTECAAEVIRYMDSVTGVTSDVRSRLESHLVERLRGSVSAPAAAAAPTSAGAAGITAAVPMSHSSMSATRQHNQTVRLAPVYAGDAMMGNAMTSHHAVNHMTGGSDESSTHYQTAVDLANMAAMVTAKDINAASSSSVQPLNGGSQCVKQERTSSTSCTFSKAQCTSPQKQHHDQMTTFSDQQTDSYGSRSHSIPSPENVGYQGIPTPESAYDDYSPSPSPVHNKRRRHTSTSSTESLTFRRSPDSEVFTDCRGGQNDRNNNYVSDPNNNYLSHNYNNDNNNNNNDIVLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACU0</accession>
    <name>A0ABM1ACU0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase PDZRN3-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945245.1">
        <property type="nucleotide sequence ID" value="XM_013089791.2"/>
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    <dbReference type="GeneID" id="101858817"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06716">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051971">
        <property type="entry name" value="E3_ubiquitin-PDZ_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545">
        <property type="entry name" value="PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545:SF8">
        <property type="entry name" value="SLO-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945245.1"/>
        </source>
    </evidence>
    <sequence length="850" mass="93715" checksum="148D20F97DA0EBC0" modified="2025-10-08" version="1">MKSRCPTMVSIGTQTEEDFYCYNRPPTPPPGYYPIPIVTGLYQPSSRRPVAFSPSAEMGLTDIEMAHNLDIDDPYFDDRHYEMVYEEVLLRRNSSEEKLGLTLCYGSLEDEMTDIFISEVDPCSVAGKDGRIREGDQIVQINGVDVRSRSEAISLFSGQNTDISLTVARPQLQCDDGFLEEPNMVLDDLHMDLLEKHHQDNMQFMASMLARRHIDEEGGTTDTATTENSSQKHEKDSGVGRTDESTKNDESSEQDTFDSESLITPPTTTSKTRHPSVPEGHYMSTDVTSDVMCTKFRDMLDHRCVSAGNSPRRGDGSRKDSESSLERELAILNREMEEIQVECQDLVDNHMREQQRLAGFNESVIRGDTQRSPRVVPRMGTRLEFTKHPGETWTQKEAGMGRKSGASPSQTGPPSPASANGAVNINNNLMNVPPGYSTAMSIAPTGGAKNNLHSPSGPPSGLSAATSTSVSSSVSSTMSSSCRGGPASSEFTSHTNTISSSNASSGLCEREREAWTTTSAYNTGESCRSTPLTLELTPGEHEYAEPGLSGSMLCLAATPSTNSSGTAILTSDTEKQTQTPTKSRDYSSEDSGHVQHNKGSNSAPSLKAMSIAESMKAGLAHPAQLGESLQDLYLRCADVMYTNRANLEHTIAVQQKLFQQQLEQQSRLRGHAHSPGHSTGSGNDVTVGEVAAKNSPGNTAPSDSGQMEWVVKRRPDGTRYITRRPVRSKMLKERAKKISEERCGMTTDDDAMSEMKTGRYWSKEDRKRHLEKAKDYKKRKELFVKAKMETLKETEEKKEMNIVELSHRKMMKHKGKKVFDNFTTVKEMLAHGNKVSDGKTYNPLLSVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD64</accession>
    <name>A0ABM1AD64_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Formyl peptide receptor-related sequence 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101851907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945443.1">
        <property type="nucleotide sequence ID" value="XM_013089989.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851907"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="76"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012945443.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41825" checksum="D14B4E60BEA3110B" modified="2025-10-08" version="1">MSHTSLPSRMSISHLWGNNTTNSRDQYIMYMSLPMTTPSPSGSYHENIVSDEQFHIIKVVNVVVISGVLSLFGVASNIINIVVFAKQGFQDSMNISLMGLAVSDLFSLLTTTLQSICVNPLFYNSELPFDPRDILYLTASVPHYLFVKIATFITAFIAFERCLCIAVPLKVKTIITRGRTKTIIIFIYISMSLLIIPFCLGNRLEWVFDFNKNATVLKTTFTAEREMLEAITFLTQGVFATTFSFVFVLCCTIVLIVKLNSKTKWRQATAAKSDRAAGGVGVKDQKVVKMVTLIAVIFIACSLPSTLLFLYMVIDTDFRIDGFYINLYHVLWSLAFLTETTNSSVNIFVYLKMSSKYRAVFMKIFLNKQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFF1</accession>
    <name>A0ABM1AFF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flocculation protein FLO11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106014111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946613.1">
        <property type="nucleotide sequence ID" value="XM_013091159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014111"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946613.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="50237" checksum="07C06E9459475C66" modified="2025-10-08" version="1">MPDPTPFFHDIWNAACTLISQLKLFSFSFFYRPGRRSSLLSSLVWDPVSGTSVIRPPPAPPSPSPSSLSSPVSSTLLPFSSFPSNPEQSATQGETKKLSTAAETKESVTENCGSVQGRSTSLPCAPASILVNSEGVGNPPLQGVSDVILGNEGVLSPCTASFTEPSITTCIAVTSSTFASACVNGVSRGRSTTHIVNSNCSTPATPHPQPSLTSNSETTAINFSTKPPSGIPTSSEELVLGNSENRLGQSELEKAKAYLNIRRATLAGTAGSLTAHPVCLKPETVSFSVAFGVFAAGAPEKHAPSLQRKASLPDTPRTGVSVKALVRKLSDIGSANGHTLKTKEGVRERTEASTDGVPLVVSGLVSKFSTTLPLPGQERDSMSSKDLSKRKDKIAENADASQLSSSNSLRNTSESDHIPARATPSTPMRRWLSSVNHQEEARSGPWQQRHYQPHQQLQQQQQQKQQQQQQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFN3</accession>
    <name>A0ABM1AFN3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Galactose-3-O-sulfotransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC106014177</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946721.1">
        <property type="nucleotide sequence ID" value="XM_013091267.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014177"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF87">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012946721.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="63126" checksum="D76CF97AAE0A361B" modified="2025-10-08" version="1">MQSRRITLYVTVLLVSNIILLTTRHYGQYNAALRRREEERVLPKPSYRNVHFSESTATELTIGEKVEGTADSEEPATSVERSLSEEQTSENVHQRLQELETSVRHTNDDAVDFRAALLFNMPSTALGKETVRAYILALGNITSKYEILLKKILAASPSLKIIDELKTAFTGNETHNASFEDVLVPVLSSTPDVSKHVQENDTFRELDAAAPKQTLQNVAFLKVHKAGSTTVQNILQRYALTHQLNVVLPNKNKTTDPHYHYLGDRNGFSGNDIIPVRNGETYNMILNHAVYNRKSWSSVLERESTVYLAIIREPESRFLSAAFYYGLVKRLHKRNPSPNSTKFIFTEYLKNPKNYTTSHYFYNAMSYDFGIPESSYNNPTEILQHAKRLVEEFDLIMLVEYFDHSLILLKRRLNWQLRDILYLHNNKGARKASEGVFLSAEDKSTLRKWQSADVILYKVFSDFFWTKIQQERGDFFQEVEHFKNLQGYLLAFCSSPKQDDVLTVKQSKFNDAFSLTTFDCNKMMAKEFDLHDELVHVAWGRFQSEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFP3</accession>
    <name>A0ABM1AFP3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxylysine kinase</fullName>
            <ecNumber evidence="8">2.7.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101854836</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19049"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57882"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58357"/>
            <dbReference type="EC" id="2.7.1.81"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.81" evidence="8"/>
    <dbReference type="RefSeq" id="XP_012946736.1">
        <property type="nucleotide sequence ID" value="XM_013091282.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854836"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050249">
        <property type="entry name" value="Pseudomonas-type_ThrB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064:SF1">
        <property type="entry name" value="HYDROXYLYSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="11">
        <location>
            <begin position="65"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012946736.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43382" checksum="93091096BE479C6C" modified="2025-10-08" version="1">MDVTDSNMNASKENSNLEPPKEILCPNVQEPDIIQHLKVNYGLTISKVSRLNGYDDCNFNVQAEKEHSNPNIQQIAPNGYFVKVSNIMDSENPEMLHAQMQAMQHLVNKGILCQSSVKSIQNQDFTDIKATTKAGEERTHKVSVRTFLPGELLAKATLTPGALYNIGAYVAKVTQALEDFHHPFYDTFDCLWNLGNVPKVAKVTHAVKDEKRRRICEEVLKAFDDEVIPQKPNFRKGQIHGDLNEQNILVSEVDSVANDIQVCGLLDFQDCAFSHPVYDLAINAGYMMMVESTQVPRPQIPGYLLAGYSSVLCLNQAEEKVFHTLAASRMVQSLVYGAYTYWLDPSNEYLLETAKCGWDALVTFWKTPRETVESDWKRIIGSYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFX3</accession>
    <name>A0ABM1AFX3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Golgi apparatus membrane</location>
            <topology evidence="1 5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_012946869.1">
        <property type="nucleotide sequence ID" value="XM_013091415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850684"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23462">
        <property type="entry name" value="beta-trefoil_Ricin_Pgant9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 5" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="6">
        <location>
            <begin position="285"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012946869.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="48787" checksum="A128E511C9927076" modified="2025-10-08" version="1">MAYLFRSERSQCDEILDHLKQPLLDYVAKLRIVRVVRTTKREGLIRARLLGFANITAQTATFLDSHCECTDGWLEPLLDRIALDYRTVTVPVIDTLDDKTLKYTFAGITVGGFTWTLVYTWHAIPKHELDRRHSSIDPIRTPAMAGGLFSISKRFFEEIGTYDEGMNIWGAENLELSFRIWMCGGTLEILPCSRVGHIFRKRSPYKWLTSIGKVVVRNNIRMAEVWMDEFRHYYYTWINIQEKKIDYGDVSERKQLRERLQCHSFKWYLDTIYPELFNPTNALQGGEVRSAAAPMCLDGRSDTLHKTVILEAYQCHGLLGNQLWMMSKDNEIRRDDACYDHNGGENVILYQCHPEKGKGSQYWIYRDDQTLFHPASNLCLELSTMDATKVTMKECRGSDRQKWIWGKGLPKLNEEIRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG00</accession>
    <name>A0ABM1AG00_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin-33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946908.1">
        <property type="nucleotide sequence ID" value="XM_013091454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859139"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012946908.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25325" checksum="9A33A4A46686C5C5" modified="2025-10-08" version="1">MAQQNVYMCELGAVSCLLNTCITSLPFPQVVGLVMTGLGAYILSIKDKQVHDVLDFFLDPACDMCLAGSIVFVMGFLGCTGALREIVCFLKIVSFHHSATHILLLQLGCCGLSDSEKGFLDWNDNAYFNCSSTNMSPERCSVPHSNIGDSINYQCGANMIKYLPDGEIEGNNANTYRIYNDGCMKALGDWINRHALVVGGIMLGILLPQVFIVVLTRNLIEMIETQKSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VP55</accession>
    <name>A0ABM1VP55_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thrombospondin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC118477251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824197.1">
        <property type="nucleotide sequence ID" value="XM_035968304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477251"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035824197.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13488" checksum="FCDD00806C9BEF2B" modified="2025-10-08" version="1">MRQRFCNNPVPMGQGAQCSEPLIEEQMCNKQGCTPTGYAHGTSFGGTCGDQRGLFDCKNGIQCIDINLKCDCVPHCTDFSDEDVAYAGCVMDLIDCLNGAGIKDLMFSLGVAALTASLTVFRVVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQJ7</accession>
    <name>A0ABM1VQJ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Myosin-I heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101862252</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824689.1">
        <property type="nucleotide sequence ID" value="XM_035968796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862252"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17208">
        <property type="entry name" value="FERM_F1_DdMyo7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051724">
        <property type="entry name" value="Actin_motor_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049">
        <property type="entry name" value="AGAP003327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049:SF5">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="14">
        <location>
            <begin position="726"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="13">
        <location>
            <begin position="877"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="879"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="14">
        <location>
            <begin position="1282"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="1445"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035824689.1"/>
        </source>
    </evidence>
    <sequence length="1771" mass="202704" checksum="D4FAEA4A6A31F447" modified="2025-10-08" version="1">MLDEECRFPQGTDKSYLTKQHQELEEHENYIKGDRRNWEKEFGIQHYAGVVVYAVQGFLEKNKDTQQDQLFDLMHTSTNIFVEDLTRFQDLLGVRLEFLQGRQTISRTSRSKPTVGDTFKHQLSALVDVLDLTNPWYVRCLKPNSQKRPNDYQPNEVLQQLRYSGMLDIIRIKREGYPVHVPIDTFLSKYGVLLDQGSQGGDATGAAVKVILNALELPKTEWQVGKTKVFMRNSVFEPLEERRQRLLHRKAVLIQKVWRGFFCYRSYQQKREAVLILQDSFRSFRHRLEFLRKRRAAVVLQSHYRGRLARRRAQEIRVQRHMEEERRKREEFERERLAREQESADQTAIDEALKKMKKRQSWQKILRQSQLELESLTHLIESMWTHCQPAVSASNMDLDAMFDFLKEERTDMKSAEVTKEAALNKINEEFSTLDTLWKEAEKVGFFYPFCALLELIQAFLDDYPPPPPPPPPGDGPALSMPQLPTPLTPPPGVSQATAFISSCIDFPPPMRDKGTTPPPPPPRISSATNGDLLPPPPPCMTNSQADLSSLPNGDSLPPPPEETVVEGENPYAELKEVHKAIHESLVNGGFESPAPTPPAVPPIRRPGPPSVPNTPRSSMALNFSISAQHYDSEVAQLSPVTHEKLSSLMNRASREMNSHSEPSPARDLEESIPEPDALYDILEYAEKYFNDHERDAGSTIIKSLKKKNKQPSLSDCLTKAEMLKYSKSGLIPTSHIHLHDSENIHLACLIFKEVTKYMRDEVKDDAAISLVQWLVKSGIDRIELRDEILIQLLRQTNENPDSSALANAWSLLCLCTAAFSPSKHLHKYLVSYVKRCCSDPVGGRHAMMCYKQLTVARATARRFPPSTIEILAVQSLNPIVSKVYFMDMKTKAVSLYPMDTTQELLSKVARKIGLQSVEGWAIYEVTEDHERFIRSYEYIADILAQWEGQNQLYVQPTKYETVSKKGPKMALGGEGARLVFRKRVYRHVHDIPNDPIEYHLLYAEAAHKVVKCDEYSVSDKVGLQLAGLQAQVIWGQFEPSKEFRYSEADQYLCKRILASSGKNWSQEVAKAHMHYGADKSELEAKVWYLTCVKQFALYGCTLFPIMHKGMWSHTSESLLAINMDGVKFVRAKDKYVIHDFKYHEIESIMIDPNDNYLTLELFSKAQSGLMQKTFVFETSQKDDIGHLIASYSPAHATWMKSDNEGMKKIKMTDDDKLKLYEELVRCRKALSESRLLQRPANDSATGFLRNTLRRLTKPKLEKLRSWSSSDAGTQFSVDYWSYTKTAIKQSLTVIHDPSLEEAAVKMFTQILIYAGIEEHADPSDPERISLVQMLMQKCLESDFTCNEFYLQLVKQTTDHPDPNSTVNCRSWQLMAVTASTLCPANTRVQKYVLCHLKKCSMDTTTEEGKFARFSLKCLNRTIEKKRRKFAPSGREIQCVIQRKPVTQKIYFLNGEQRVIEFDSAGTCGEMIKTVKTKIGMRSDAECFAMYEIMGTSERAMTCDERLSDTISKWDRLSRSGAVKELKLVFKKRLFIEPYVNNSDPVECDLLFNQLIEDVFEQRIPVSHKEAVHLCALKVQSEIEDMKSGDIDYTSVMRILPRDMRCTVRPEEVATTHKTVLDMSPHQAVVSFINLLKNWSLFGATIFEVSQTYTSTMPKNLLLGVHQKGIYLLEMNTFDVLSSYGYSDIVHSSPAIKSIMIVIGHMAKGIKFMFNTNQASQIAQLIKDYMEELQARYMLTPTENSNRMSRAFDIDELERTNAYLQNFDIDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR92</accession>
    <name>A0ABM1VR92_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">KAT8 regulatory NSL complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC101858144</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089509.1">
        <property type="nucleotide sequence ID" value="XM_005089452.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089510.1">
        <property type="nucleotide sequence ID" value="XM_005089453.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824934.1">
        <property type="nucleotide sequence ID" value="XM_035969041.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858144"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056519">
        <property type="entry name" value="KANSL3_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136:SF16">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="TESTIS DEVELOPMENT PROTEIN PRTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23154">
        <property type="entry name" value="KANSL3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANSL3 helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="915"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005089509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005089510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035824934.1"/>
        </source>
    </evidence>
    <sequence length="1218" mass="129459" checksum="CE8DAE6373287F72" modified="2025-10-08" version="1">MIKMEDNPVRFSPFSHRNPNEVSIVCIDHCYAKPWSTHPDASNAQPLRMLFMEKFPRPETRDKESTDTDIDVEGEDPVSTLPYDVNKARSQMVDCEKHAALLCPDQSEMRDDWEENIAAMRNSWSVLQNRVFAKVMRVLQADRLSRLSIQETKNEPILRRLQVDKAARRVRQAFANVGWDMTLILWIHNLFVENLRGQLFISYLEVLQTLKAKIPSLIDRLISGTTLKQDTLSSESLNALLKKSWDPVLASINQQKLKKLPENPLLLVIPSAPSFVSNPLSSKRHKFWYSQMAAMGKVINVIPINNSTSITIANCVENMIATVRSKLLEVKGHYPGRPIVLIGWHVGAVVACHVALMEIVQAVVCLGFPTMGVSGNRWDIEDQLYSCKTPTLFIVGQFANANSLDMLEEVREKLRVETGLVVVGGADDHLRMCRAKKRSCNVTQSMVDRCIMDEVFDFLGSILCQVNLQSEPMEEPEPVKKPRKRKQKDLATTVSSQTIGNIAKQSSLKVAKALALSSSSTSMLSGQVSVSAPGKIAKRASPKKKASKSGGDPAVFGKKPLLHLSFPSSPTTSVPGETTTTSTAAVSSVSEAAAIASAPELSNLLQSIRTSLSRSSNTVSTLSPAKVISTSAPTTNSAQSQTPASSVSGSASSSSAASGLSRFLASSALLRNTSLIKSAELNASLTNTVDTLNTSGPKQQPQILIRAGPTSEPFSIPLSFSMASKVLKTSSGVKLGDSLMGTSQIQHLLASSPVTSSTTTASSSSSAPSQLLQVSAGNTSSVSSSLTSSCTPPLSTFSSPVPSCSGSTSVSVSSSVHTSPGASIFNMGNDSVSMKESPPGNVPAPGTVSIDLGQIASSSSSNVLKLNSPPKVSLIPLSKQLQGLSGTSPERALLGGQVGSPEVPSGQSLLAQQQTPLESLTPSTHTTTSTARSLQLLPSTDSSKNLTPISHRGLTVTPTTQFLSTINSPSGLITLQLAPSRKDSAATVVTFTKDQTDVDAKQRILQQQILHLHDLASSTKQVDSTSVVSSFSKSESEKKLSQSTEQSPSRSSTSTLSTLVMTPASKASYSPGQIVLQYKSPSSHTLLSHGSSKPGSPQMVIATTSETLGQVTSLLESSPITLGDQRRGSSILSSPSQGGQDSPSPLSKAMSRLSAPSPSSSSAVSSTSSSPNPSQSSSGATRASKTTISSYTATSKPVLPTIASTRTRRIKTPKQYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRG0</accession>
    <name>A0ABM1VRG0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101858098</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101858098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825002.1">
        <property type="nucleotide sequence ID" value="XM_035969109.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858098"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1405"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1433"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="843"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="932"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1331"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1537"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="987"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1183"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1221"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1332"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1539"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1552"/>
            <end position="1561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035825002.1"/>
        </source>
    </evidence>
    <sequence length="1603" mass="171694" checksum="1EAECE603F527174" modified="2025-10-08" version="1">MQEGTDDPEKDSDRSELCGKSYKAKRSLHQHHQNTHHKDLGKMLPPAAVSSLPTQVPLHSALLAQQSPTPAISEATKSLLRETLESSRKAKDSSSSSNTSQISSADTLHSSSSSNGGRLSDRLSTPNLVNLLTSDISHKGHAAAASDGAVALLKNKSRADGIKKEGELMMSVKTEMVEEEQAEDLSVRTTAAKNQVKVKRSPSVTADDKKVHCEFCHKSFKHDVSLANHIRTAHNIIVNFPESQPAPQPPKLKQNRNTTSYARIEPKPNGNPLVRLSDVLPNSMYATDGVNKLDPVAADLTISSLLARKVMERPNMMTANAGVGVAESSAGAGGGGAVLNGSGVVNGGLGSVENGALDESNALPYHVTSRMVQDLSLEELSSREPEKQAVLAEDGGQRRSRITVLKETVLVSRLDGINNVTGRQATAFQCQLCKRAFTSLVRLYHHLPNHFDSEVNTFDCRYCEASFRLQTQILKHLQCHKDKFSGLSNVSLPLEDIQKKQKDQSSDNVTPASSGSNSSFLSPGYLADNSLTNTPITGRFPEPGERANGGYSCTKCRKSFSREYLLQRHMRIHQNQNSFWCPDCESGFSGETDLMEHRRACHGTPKVSDEQMKYSNLLNSLSASVYDQSAAAAAAAVAAAAQSSKLVVANSDSNNNNSSGNDNNNLTSATAAAVAAAKSGLPASTSQRLGLYPPMVDMKAIDLRHGEEVAVRMAAEVGDAEREMLARQAVLQEFQKKALLMKAMEAQTDKRTAGTGLDFEQLKKTFPTLGQKQLEAVTSRILQENEKMRLALLKAASEEEQRQRKMFEKLSEKKRREEQEAAARLLEEEKRRRQLEQEKLKEKLAQEGMGDVTVVMPDAPPSDSGSGDDGDARAGAGQVEEETETAVDFSTTSSSLRKSEGVVAVAAAAAAVVGGGGGDGGNVVRCEAGKAKSEGGAEGKDTGSETAVSAGVKRRSPVPITGSAPPTKSRRKALKPQRINHCEEETGTSPTSETPTPGGDVGVVKMDTDQADESSSSSPAHTAESSNKNKFVQIHPAHFASNTLSQLNQLASIGAIGLAPATPLSELARKQLAAAVTSRGGMGSLVVTPSGLKYMDKAIPGYDQAALPMLFGSMSGGQILNASSSSSNGGSINNNNNSSTANMAIDLSTTDSGGVRQGGAKPSVSSPPPSNYETYMREMNLLSSAPSSSSTAAPGQATDLSQKSSSGGKKKSSKSSLSRSNSHEVRSLTEGGDHSSQDLLAAAATDLSKTSLLNVQIPSLSNPTAASAVLLSKLAASQLSGLEVDPDNLVGYPRVQWKQQMTATELAELGMLVNGSAQGFVKDGKAQPFFLNTNSNSNSSNKSQASSPSPAPSPTNSDASSSAEGRKVTTTSLSRTHSRLCVVNEPVDRNALCKPKVLDDGRQVFSCAICHKNFLSLSDINRHMDFHEDIRPYKCKYCDYYARTNSQLKVHKLRHEGVREFCCRICNYKGVTQSDLNRHMKSQVHVLRSQNVCERCGEGFVTPRNLEEHQASLCCGSPDKNFLHDSKANDEDLDEDHHHHLHLHHHHHMLDAEELEEEDDEQQQRRVTAMGEEGSALGLISASDVKRSASNGAAGEVGEPMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT65</accession>
    <name>A0ABM1VT65_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101851407</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035825607.1">
        <property type="nucleotide sequence ID" value="XM_035969714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851407"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21339">
        <property type="entry name" value="VEGFR-1-like_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01832">
        <property type="entry name" value="VEGFRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="240"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="449"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="736"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="909"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="943"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035825607.1"/>
        </source>
    </evidence>
    <sequence length="1194" mass="133308" checksum="24FEC82A92CCC13F" modified="2025-10-08" version="1">MGKITSLSASQQCSLVLGLLFVHGLFIGGTAQKWVESALSAPPRIMALDEVVLAKGDNFSVMCAGSSPVKWEYESPEDLFSNIGPDNRVYTEEGGMSADTQRTYRQILHIESAEHHNARKYECKYDDNDDSSPSSSIFVFVTDPEEPFQTKPLRYPFMRPGVPVVIDCGVTDPSFRVDLFANNNNLTGTEGVEWDPRIGFVVRFPTYDLGTNCYCQVVIDGRVFKKRIYAIFRGVEDYIPTPYIEPNGVFFIMAGETMKLNCWVLVGRGSMIYLGMQYDLKGKSDRFDETLPLREQESGGQYDVINIDLTVENVQVNDSGSYVCNTSFDLKMYEVAPVQVNVYEKPFVTLKAVDEVLIAMDTDLATLLRVFWTSPTEPVVEWYFDEKIINVNTTNGCSYLSDKRDELVILNPKTEDSGIYRVLAYVEAENGTRVASSTVEIELKIHGIPNAKIWAKSADANLPDGMVTGRVGQQVKMTCLVKGYPRSNVTWLYQPCQTTECELSADNSTWQEINSTEADMQVVTNQFNQQLYRLYIQPQGTGYFKCHAENSHGQHSETLKFIATDSDGMLNVTDSANRKIVPGDSLKVVCSANMWLYNSVTLYAVDDSPLTTMLAKKMAMNRIKPDQTTTLATTDAGLTTMGSGFTAVASFTTDEAINSTSNVTTPSPGTDGKPGSLRTGPRIIHERTEHSIKVALVFDKLQASDEGLYICEGISSLENASHTRHYQLTLYAIKKPMVYSQTTGSRQVEIGSSAVFQCGVTGLPPPVVTWYKDKKLLLQNSSRFFIFTENSLTIENASKSDEGNYQCKGWNYGGEIWSSNMTFLVGTGSTNEASFSPAYIGVIVGIVLFIIIIFVIVIIRIRKSKSGFHKELEHFLIQPEGDYNPDLPIDEQTGCLPYDPKWEFSKDRLRLGMILGQGAFGRVMKAEAIGIVDGEDVTVVAVKMVKDCTDKDQMMALLSELKILIHVGQHLNILNLLGAVTKDIRFGELYVIVEYCHFGNLRTYLIKNKAHFEDTMEDCENFMPDVKKEPVSSPNKKGPYYLNIAGGPMGSADVLGPSLTTKNLYCWAFQVARGMEFLASKKYIHRDLAARNVLLAEDNVVKICDFGLAKDLYKDPEYHKKGDGPVPVKWMALESFTHRIYTTKSDVWSYGIMLWELFSLGGNPYPGVEINEKFIGLLKSGYRMEKPQYASPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTV1</accession>
    <name>A0ABM1VTV1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thymidine kinase 2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825843.1">
        <property type="nucleotide sequence ID" value="XM_035969950.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855258"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF24">
        <property type="entry name" value="THYMIDINE KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825843.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17920" checksum="E668C9721095D73A" modified="2025-10-08" version="1">MAQSHVRPQTERVRLMERSLFSGRYCFIDNLLQGGKMTTIEHSVLSQWHDWIVDALQIKVDLYVYLRTDPRVIPDRILKRGRVEEKDIPMKYIESIHGQHEDLFIRGMKVYKPNVLVLDANCSKDEMVQLYERHRDQILHTGANSHLPPVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUF4</accession>
    <name>A0ABM1VUF4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Steroid transmembrane transporter SLC22A24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826046.1">
        <property type="nucleotide sequence ID" value="XM_035970153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011960"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826046.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15669" checksum="AC863F708328F3A1" modified="2025-10-08" version="1">MVAQDFDDILDQIGGFGRFQKILCTLSFFLVIPAAMITYTPMFILTVPKHRCALEGYQGDTYAVQNDHHLELINASIPLNDDGNMHKCNILTGNEDLWNSSVPAGNATGVAQCTKWVYDKTMFDRSLIEKVKGRHYLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUJ3</accession>
    <name>A0ABM1VUJ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Keratin, type II cytoskeletal 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826085.1">
        <property type="nucleotide sequence ID" value="XM_035970192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477819"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046217312" evidence="1">
        <location>
            <begin position="21"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826085.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="21892" checksum="2A9D788B2A77D8BE" modified="2025-10-08" version="1">MNGLSTVLTLLALLVATAHGIGAGGYSGFGSLLGYGGGAGPLYPGIVGVPGVGGKSHGHGSDEQHGFRGGAGFGPVRAVGGGYGGALGGAYGGYGQYFGAGGYGGAYGGGLGVAGGLGAFAFPAFGSGGIHGGLGGHGGHEGKGPHGDSVPGVIAEVNVSPGTASEINIDNLSGYSSLKDLAGLGVVVCPSDSVDSDYGSAKCEGGILSCCALHYDTEDQSLSVHRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUN3</accession>
    <name>A0ABM1VUN3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prostaglandin reductase-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826125.1">
        <property type="nucleotide sequence ID" value="XM_035970232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856943"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="19"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826125.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="37799" checksum="E02048ACECE8A41F" modified="2025-10-08" version="1">MAALPATQKQVEVKKLVTDFHEITQIASGPVPSPGKQQFLIKTRYVGINATDVNKSAGRHSYSSSDLKLPFVAGMEAVGEVVKVGDSSKFKVGQYVACLPSGAFAEYAVGDDMTSILLPSASAEFLALFVSGLTASVALEKEADLKPGKTVLVTAAAGGTGQYAVQLAKLAGCHVIGTCSDDAKAKFLKGLGCDRVVKYTEEDLNQVLSKEYPRGVDVVYECVGKEMFDAALKSLAQFGRLIVIGQVSAYKDDDNVRSFQGLALASKSSDICIPLTLMFKAASIRGMVLGAYMGDLQRHMDTLMKLLKEGKIKASTDMGKNVPSGPFVGLEKVADAVDHLFSRKNIGKVVVEVGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUU5</accession>
    <name>A0ABM1VUU5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">RecQ-mediated genome instability protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4" type="primary">LOC101855796</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939120.1">
        <property type="nucleotide sequence ID" value="XM_013083666.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826186.1">
        <property type="nucleotide sequence ID" value="XM_035970293.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826187.1">
        <property type="nucleotide sequence ID" value="XM_035970294.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855796"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032245">
        <property type="entry name" value="RMI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33962:SF1">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33962">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 2 RMI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16100">
        <property type="entry name" value="RMI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012939120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826187.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16610" checksum="35DD9E142DE8B128" modified="2025-10-08" version="1">MSFLQKPSRKIFVNFLSGGAGAPWEDGQSSDQHRDRDLRCFPPEDYVKVNSSVWMQGTVAQVKEAEDNAVILNDGTGSVLLPACDKVASKIPFKKGMYLMVVGSVLRLGREPVVRPVKIQDLETQPRARDLWPLEVRDQVNFLNKTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUZ0</accession>
    <name>A0ABM1VUZ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC118477165</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118477165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826232.1">
        <property type="nucleotide sequence ID" value="XM_035970339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477165"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730:SF1">
        <property type="entry name" value="PLAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730">
        <property type="entry name" value="POLYCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PKD/REJ-like" evidence="6">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826232.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32021" checksum="3B710B6E96F40160" modified="2025-10-08" version="1">MLPQHRITANLKKGTRTVSAQILLDVVSGNPPQVAIIPSSGSVYYQMSNGYKVLKSSRLGLDCVCMDCSASDVITYQWKVMMADYRWPDNWRPLEQVDVLDRVLGYESKQISIEASLFETFNSQQMRAECVLTRAGEWGKVASDLMVNNPPAPGTCTVSPFNRTITSEEAWTISVDSWSDEDGIDEYQFFIHTDEDTVDKQITSVKTEQGTLSIQVSLSEGPHYLNYKQTIIVKVRDMLGSIQEYDCGQVVFFYCCVFSQHGYHVICISTKTAAHVSFERFDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVR3</accession>
    <name>A0ABM1VVR3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian ependymin-related protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826505.1">
        <property type="nucleotide sequence ID" value="XM_035970612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012217"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047040756" evidence="1">
        <location>
            <begin position="16"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826505.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18469" checksum="9EE0CAE3F00CA39F" modified="2025-10-08" version="1">MLLILFCATLVVVYAQQPTPCHMINRPASCELWPAVGYKITTYNKLLYFTCTQNKEYKINLKARNCTVGALTRPFIHFGIPPDAKYTGTANVGPVNIPDEHATVILFEGTDRESGGFYYGEVTSPDCVPVASGYYSNQTGYLHTSFYDITGGIPDPSVFIPPSNCVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZA7</accession>
    <name>A0ABM1VZA7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein SPT2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827750.1">
        <property type="nucleotide sequence ID" value="XM_035971857.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847604"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054552">
        <property type="entry name" value="SPT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22878">
        <property type="entry name" value="SPT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPT2 homolog N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="377"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827750.1"/>
        </source>
    </evidence>
    <sequence length="831" mass="92920" checksum="AE1E11AAF0EDC32C" modified="2025-10-08" version="1">MDFHSLMNMAASKQENLDKHKVSRYSLDLPAPRKEEKPKAKSEAVQKLIKEKEMEKRKKEEAIRKKREQEEKEEKKRNHFKIPKKKAEPAPTDTEKLINSLFDDDNEADSDKSASDEDRKDKINSQETCGNDGLTNGLHSSKSHKDKSDSSRSDEDKRKSSSDGKSGHHRSSSSSQKSSSTSDRHKSSSSDHHKSSSSDHKSSSSNHKSSSSSSSSSKHKSSSSDRHKSSSSSSSANKSSSSHSSSGNHKLKHSSSDKAGSPVSNRERSSSSSNNSSRKDKHQSSSSSRSSKPHLSSSSSKSQSSSSEPKTDAVNGKSSTSPSESQQPKQSHAQPVVLSKHHLNPLIERQAAQSAPAQLSEREKILARLQAIKERTLAAIHKENDSKGKRGKREKGLGRKSKDGSDKLDEKAKSAEIVRDVVSSDEDETVDNALDIMLNENKVKIEKEKIARMAKQAWERATKKDSGDAEERPSRKRKSIHKSGSSSKHRRPGNHVKRREHSLSPLSDRESKPKFGKQKKTIVKHSGNAAPPPMDFKALLAMAEQKQNEPMKPMSAIPKKKKKEEEKRPMTQEEKDRKERIKSREYQEWLKNGGKAPCQKDMSDDEASPPSTSQTRVPPSSSSSSSRDKLKSMPSGKPASSMGATRPSFHKQHRGEPQRPPSGSNHGLNRGKANSVPQMNENVLVCGPGSDSEPEEPPAPQNSMNPFDRIVSQVHKKSRPRPPPDPKRMRLDDDFDEEEEDSDMDDFIDDGEADASEISKEIQKMFGYDRSRFKNEREEDLSDMEADFSTVMKEEKRSAKLGRMEDLEDMRMEQEELRQKALMKKQMKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1E0</accession>
    <name>A0ABM1W1E0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC118478621</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC118478621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828483.1">
        <property type="nucleotide sequence ID" value="XM_035972590.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478621"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035828483.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42351" checksum="79851BB6566ECCFE" modified="2025-10-08" version="1">MVAPLAVALLLNYTLFIMTIVRIQRVRSLQTGKGFRSEERRLFWIYVKLSSVTGAFWALAILAEIDNLTLQTTNYSVVRCGVIVASTSGPSDQVLGAHVTGRDQIPLFWVDVYLISALEMSRDEAEHVLIQTFFPKTLGASFGERKLKLTPLRIPSALIVDMSLCVNTTNDYGHEKSSCYQEDSINLRDEYSVEAYSLSYDMKSFVELSPLLNCVSLLCLLATIATYSLFSVLRSSAGWNNLLLCVSLTAAQSSLLASAMLLTRPILGGIYLLYISFLSSNEKGVICTVVGVSTHFLWLATFSWCFICCLHMERVFSAKTRNTHTTSAELRNSVMLRIAFTVLLPALVIAIVIVASWMTSDGDDIGYGRRKCYLDSGFLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W246</accession>
    <name>A0ABM1W246_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Lysine-specific histone demethylase 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101859365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828739.1">
        <property type="nucleotide sequence ID" value="XM_035972846.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859365"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="11">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="10">
        <location>
            <begin position="235"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035828739.1"/>
        </source>
    </evidence>
    <sequence length="852" mass="95324" checksum="FEDFE386A2BD3ABA" modified="2025-10-08" version="1">MKRSARQQKPNKKYFVEEEGSSDGPKRKCGRSGCPATVPICFAGVSERCCGSSWTSRWYHVTLGEHFCNECFEHYYRSHKAGYADFTAWKRKWSAHARTEGSVVAFMMEQIVPYWVQCQKKECGKWRQLSRDVDLTPEFIRMFQCGSTNGTNNNNKKGKQDPCYAPQDERVHFVHSPLWLIQNKCTPYLKKSPAAPFLTAYYADGVGLSPTENAAALSKAEKKKLCPYVLPFPKADHPLHAFAVTPDMMTEVEIESFPLLAQECPYMYLAVRNLIMSLWTLNPKEWLTKEKCTEYLICRGLARVSCVEQLPQVLAFLTHHDLINQGLVTPPANLTEPFTSLHQGSSVLIVGAGASGLAAARLLSIHGVKVTVLEAKGCIGGRVCDQDVEGSTVSFSGQWLNGCVNNPVAVIAYQAGIDLEQPNDDCRLITEDGNVIEDSLDRRIEFHYNAILDIIAEWRKGREDKADVDLLTKFKEFHQQFISETQGFFTHVSLCILKLVLFLQSSWCFVYIFFMRTQEQQSTVLSSCFAFVVHSPFLEPGPHVKGVFSQEEEQVMEFHLSNLEFACGCSLDQLSSLRWDQNEEMPQFAGARTHVASGFGSILKKFADGLDVRLNTQVTGIDYTGSEVTVTTESGQNFSAQMVILSLPLAVLNSGVVTFQPALPDSKMKAIEAVGAGQVEKLILQFDQNFWSEKIKGKTMFGHVPGPTPQRGLFSIFHDVSKPQNASTSSKHTLVTYLVGQGLSLMHDQSDQEVVTKCVCLLREMFPEKDIPDPSWYHMTHWGRDPHIGMAYSYLPVGAPKNAHSNLAEEVDSRLFFAGEATHHQFPQTVAGAYLSGVREARKVLTVLEQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2Z1</accession>
    <name>A0ABM1W2Z1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of G-protein signaling 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829034.1">
        <property type="nucleotide sequence ID" value="XM_035973141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478827"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046995">
        <property type="entry name" value="RGS10/12/14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945:SF3">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="71"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829034.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31368" checksum="862A32A0AF303193" modified="2025-10-08" version="1">MFLDNPAVDMFDEAQKQIHQLMRRDSYVRFVKSDLYKNKLMEEMEGKPGQTGDQGDGLKEQVGRVASWAVHVDKLLQDPVGVEVFSEFLRKEFSEENILFWKACEQYRQLTSDSERNAEAGVIYGRFLSPTADDPVNVDGVARSHTRTFLDNPTVDMFDVAQKQIYQLMRRDSYVRFVKADLYKNKLMEEMEGKPLQGQMPDKLPVEKREEKRVSIYLKLSARDEFLIEIFQGEFDLSEYTACPQRAASASPITGSHRVLTLRHYRSLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W328</accession>
    <name>A0ABM1W328_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YGR130C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829071.1">
        <property type="nucleotide sequence ID" value="XM_035973178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478846"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829071.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28802" checksum="229813DF26ABD1BB" modified="2025-10-08" version="1">MTTQKRVSFGCKDSLVETWIIDDADVTRKKCGDVREIWSGFYDDDDDDTMTSASDIVVASTKSTNQKMADKHVTIGDSTFVVMTPEDNSAGSSPNGVQTAQLQSNHNHHHHADDDSTTTSSATIVTANNTTTTTTATTTTTTSTSNNGNNSSDNSAVIAPSTHEQHTSSSHGASDTETHEPRKDVASSQRRRSALEEYYDVLNPQPKDQSLESRDNPFLPGGDLSREAEDLLSRATIIRDNFYLNEEEKRTLQLQQQQEQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W342</accession>
    <name>A0ABM1W342_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Echinoderm microtubule-associated protein-like CG42247</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101847390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EMAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829085.1">
        <property type="nucleotide sequence ID" value="XM_035973192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847390"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01617">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF55">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE CG42247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Doublecortin" evidence="6">
        <location>
            <begin position="790"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="6">
        <location>
            <begin position="906"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1423"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1506"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1049"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035829085.1"/>
        </source>
    </evidence>
    <sequence length="1707" mass="191241" checksum="F66CD91131E1454B" modified="2025-10-08" version="1">MDDKQLEELMVQSFIKIMMETEQSAEGKAELAQAQARDEQKRNSQVTLRLGQDGLQIRPDSDQPSQLPQQQQFQELQPDHQHQQQPQQLQQHHQNYGVNQDPNLSSFHKGYNTTPQEQVKANYPNGYDPTTLPPIVNTHYPSHHLSNHSNSNNNNNNNNNTPEYLQAPPNAHQTVLDTHGNYNLSPDLSPRGSQHPERHRRVGRDHGNFIQQNSPTGHSRPPADNGHAVSASMFDDIGPPGMPYPSPGNPDEPEDQGGGLKLVVVDKSDDDYDDNGVGGGGGGGGNGPRHHRSSDEAVELRSGGDVYPIDKHAVDRDMYRQLFVPQGAPPGNNTSDGGNKNPFPNNNSNNNNNGGVYNNMYNNTNGPENHGRSQMEGANLTHQVIPNSTFTSAVAPGYPQHPNVREAFSDNAQNQHHMQQPQQQPHQNLQHHPHQLQQYHHNQQQQQQQHEQYYNPSQPASQHPGGADPLDFNQHHGTSFQGSAVQNYQMGPGGSSYHDKQPLYSMSQIDYDRFTSVPSQLSTIREGGISQLDTFRNDDSGDRIIDSKTFLVPSPALLTPHPLAPEQGSHRGRSDFRINSQPGYKFDVVNGYNPQDKRASRANVLNRAEQLLDARRGHSTERSDSSEENRGIGHRGRIKEVEEEDGGYGEGYIDPRRAVRGTRHQALRHVNRRGFDDSTSYQSSDDVLNTLRFQPRGPVSKAARRARLTSVNARLNKQRRLKAARRYNLPPHGISDDDITSESDIMEPPINFRRQVDDMGRYEESRIRDVTNEQPRPMPPPGESVGSKGRRVYFFRNGDVHFKARQILVNSKLYLNLEKLLVNLSSIVETSTGVKHIFSWPEGREIKSITEFENGKYYVCSSTNKLQRLDYGNSKEGYWKNGKVDRKETYLFQKDGKIQSPLRRPRVLTIISNLYRDSREKLILNTSSAMNFEDILNDIVNMVNIPNPPVRALYTERKPHTRVESYSQLIRDFADHENFLACGEEMVPLEMTSKRPLPGGGPENGGKKGHRRNPRSEYGDSSPTRSSDVTGYQSNDRLKQQSKGRRRKTDSVRVDINQKTREFFPPTMMDEEDDGLKPDKKLRLDWIYGFRGRDVKQNLSVLPSSGELVYFVAAVVVVYDKKFATQKHYLGHSEEISCLTVHPNGRFVATGQISGKTPESGAHVRIWDGLSLSTYAVIGLGVFQQGIACVNFSENTHVPAESREAVSGELIMAIDDSDRHVLTVWEWQTEKMVARTTTTTDPIVSGCFYPFDDTILLTYGKEHVHFWRMFWEKGRKIMRDKLSGNFEDDVPKFVTSVCFSPSGDVITGDSSGAILVWSRDNNSVFAVNDNLSVQTKRAHKKSVSALCMLGDGTLLSGGGNEVKAWDSINNYSLVKERVLPETAGHVRTIVPISAGGLDGSIYVATTRNKVLEGSLQLKFKFVIQGHVEELWAVECHPLEQTFVSAGHDQTVVKWSAVSHAPVWRVNVENPCTSISIDPKGRLIALGTTSGKVLVLNSYNGIQLTTLLAGTAQINALSFSPDGKQLAVGTFDGFIQIYYLQDEGHSFFRSQSSALKHGNMFIMHMDWSIDSKLIQAVMGDYDIIYWDTTTMQKIKAARTLRDVKWATHNCPIGHSIIGPWQNLDRGDVINVVSRSQYRDLMVAGDNRGRLRLYKWPCSLQKAGFRNTKTYSSNVTCASFSCDDSSVITSGGNDAALMQFSVLDPVNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3K4</accession>
    <name>A0ABM1W3K4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADPH-dependent diflavin oxidoreductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101845057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_035829247.1">
        <property type="nucleotide sequence ID" value="XM_035973354.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845057"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="74"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829247.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="53091" checksum="F09732C7D3EA7895" modified="2025-10-08" version="1">MLWASFCRVDAVVSPWLSELWAKVMEMWPLPSGLEVISESVCPPPKYKAVFVDMESSQEERPLPVSSDISPGPLCPFHARLLSNQRVTAADHFQDVRLIKLDITGSGLSFEPGDVAMIHPENLTDTVEAFLSLLELNPDQMFRLEENDPDVPLPARFPSPCSIRWLVTHYLDINSVPRKSFFELLKYHADDELEREKLEEFCTPEGQEELYSYCNRVKRTILEILEDFHKTSKRIPFDHLFDVIPALQPRAFSIASSIKAHPTQLHLLMAVVRYRTKLQNARRGVCSTWLSSLSPDRQDTYVPIWVKKGTIRFPADHDVPLVLVGPGTGLAPFRSVIQERASQGKGGVVLFFGCRSKHKDFFCEEEFAKLEEKGLVSLHTAFSRDQDEKIYVQHRIREQGRQVWNVLSEQNGAFYIAGNAKSMPDDVKEALCDVISEHGEMTKEQATTYIQALERVRRFQVEAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3M6</accession>
    <name>A0ABM1W3M6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101849581 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101849581 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101849581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829269.1">
        <property type="nucleotide sequence ID" value="XM_035973376.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829270.1">
        <property type="nucleotide sequence ID" value="XM_035973377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849581"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055121">
        <property type="entry name" value="HTH_69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705">
        <property type="entry name" value="AGAP000321-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705:SF1">
        <property type="entry name" value="PNP_UDP_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22979">
        <property type="entry name" value="HTH_69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="1">
        <location>
            <begin position="172"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Winged helix-turn-helix" evidence="2">
        <location>
            <begin position="343"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829270.1"/>
        </source>
    </evidence>
    <sequence length="748" mass="84832" checksum="72EE509DB53F41FF" modified="2025-10-08" version="1">MGSKDNTEEVVLTAMKKNGSSMMRMERMRKKDINFKLVHHIAGGPYKGILVNKQADALVSVDPPEGRVEFMAYLINSDQNNAAVKDRWTLRFWFRGQADGVTKKKTFTDYFSELISPKSLPRKYVGFIKRALVLLQGYSLVKRLELEVEELDEGEEDLPPIKSFVSVFTPDNYVYRFVPEVVVDNKTFLTFKIKAKCEANIALCAIYGDVERKTYEISLGAEENNKSFIRDGSLGPVKSEAKTVNLLSDEEFRYFWLSWANNHVEVGRGAKYGQATFLSWTVPPNRQFKVNSMAVATCRDSKGQWEFAEILDENEEEQDEKDFKREAKRNKIKLSLLWLAKKQRMLQVLEDAYPNSLSTNNLFKSCKMKATDNITAVVMLKDLEKKGLIQEVEKGIWMRMQTKEEMSEHEVILVQELPTLTGREQPSIAVITTLYHEKLAVDAMIEDKKTYVKFKTEASGSHSAIGESQVYTIGRIGKHNIVSTKLAKMGDAEGDMIAAENTVTRLLGTFNKVQHILMVGVGGAVPSYSDHQEHVRLGDVVVSTPADDTGAVYVYCSKVEKIKNATGYSYVTRIFSPREQVLLNAVNKIRRQAESSILPERPWERHIELGKDILRGQESNFHRPMIKRDKLFFTKPDGSVIQVEHPRPTGYAARNYKEGQTNVKYGVIGCGQRVARADPLRRDFAQMNGIKAFHQEHDAVLESVEGNCCESYLVILGMCDYEDGFKKEWRSYAALAAAAYMKALVLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4L7</accession>
    <name>A0ABM1W4L7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBL-interacting serine/threonine-protein kinase 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101862853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829610.1">
        <property type="nucleotide sequence ID" value="XM_035973717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862853"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829610.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="30804" checksum="D4092674AE6D6BF0" modified="2025-10-08" version="1">MEKVDEHAAAFSALNLDRGLCVGKGTSAEVVLASSRDDVSRKCAVKIFDLLKDNRCNEWGFIKEVDVLKELRHPRIVSLLTSLDNPCHGYIVLKYYPNGSLEKSLKAVEPPQVLGYIRDIGAALEHTHSRGIFHRDIKPANILVDEEDRAVLCDFGLSGRLKNGNTKVTRWVTTRGFHGPETKKGQAMCPYKLDMYSLGVTMWVCFYKCYPVNFDPLAGSGYCGIVKDPYRTVLLHLLHEDPEQRWSASDLLREAPLPLITPKDTPRPAMDCDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4M9</accession>
    <name>A0ABM1W4M9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein kinase ppk34-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829622.1">
        <property type="nucleotide sequence ID" value="XM_035973729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854144"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829622.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31525" checksum="5F74B7849DF36801" modified="2025-10-08" version="1">MATLTFPDVTVIHDGDFLDNFNLKFVRVLAKKKNSLVLEASMKNDDSIRKAIKKIPYLDHKGRHRGLKDSTEELTIMHNVQHPHLMKMDWVVKCDSFLAICMPLCSQGSLDGLRQSLQRDQVERVFVQTACALRYLHDQRCVHGDVKPDNIFLDASDNAILGDFGCSRILPDRKNTVSRWRGTLGYLGPECFLGCKFDPFLMDAYALGATLWSLVFRLRPADLDLLDVVRNSSMPEMYRKVLKGLLRRDPQMRLSVPGLLEFLSTREKLRAIMEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M4VN01</accession>
    <name>M4VN01_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuronal acetylcholine receptor subunit alpha-7-like precursor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Nicotinic acetylcholine receptor subunit type N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101855987</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="J. Neurophysiol." volume="112" first="446" last="462">
            <title>A potentially novel nicotinic receptor in Aplysia neuroendocrine cells.</title>
            <authorList>
                <person name="White S.H."/>
                <person name="Carter C.J."/>
                <person name="Magoski N.S."/>
            </authorList>
            <dbReference type="PubMed" id="24740855"/>
            <dbReference type="DOI" id="10.1152/jn.00796.2013"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KC411662">
        <property type="protein sequence ID" value="AGI03854.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001267779.1">
        <property type="nucleotide sequence ID" value="NM_001280850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M4VN01"/>
    <dbReference type="GeneID" id="101855987"/>
    <dbReference type="OrthoDB" id="6097775at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6 12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022259263" evidence="6 12">
        <location>
            <begin position="19"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="8">
        <location>
            <begin position="26"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="9">
        <location>
            <begin position="239"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGI03854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="NP_001267779.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56200" checksum="4F6BA5BE6EE6D578" modified="2013-05-29" version="1">MLIKAAIVLALHVTTAVAGNVGAAQAQLLGDLFTTYEKDVRPICDTDVALDVYVGLAIRQIIELDEPKQILYVNAWVRLRWFDCHLQWNASDYKDIDNLIVPFNKVWIPDITLYDNAGDGLEGSKDYLVSVSNTGVCRYLYPTVIRVLCKIDVTYFPFDTQACPLKFGSWSHNGFELNVVNSSNAGDISSFVENTEWDMLSLPVKHNIEYYKCCPEPYPDVTFTVTIKRKPMFYVLNLLFPCVLITAVALLGFLLPPDAGEKVSLEITVLLSLAVFLLVVSETLPASSENFPYIGVYFAVSMVLVSMSTLLTVLILNLHYKGNLNRPVPNWMRTVVFHWLGRVMLVERDSCTIFPESYSEVKAPNKNGASNEAFQGETYSNGYQGFNGKNHIHSSNNGGIPLGEEFSEETTSPTPDHRPHRITPITPLSGEVPASFAPFAEVLKQQLAIMEKEDARKESKLRHDHLASEWKKVGIIMDRFFLAIFAIVLFISSVVILVQLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAM6</accession>
    <name>A0ABM0JAM6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein regulatory complex protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089287.1">
        <property type="nucleotide sequence ID" value="XM_005089230.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849806"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052267">
        <property type="entry name" value="N-DRC_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14690">
        <property type="entry name" value="IQ MOTIF CONTAINING WITH AAA DOMAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14690:SF0">
        <property type="entry name" value="IQ MOTIF CONTAINING WITH AAA DOMAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="580"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005089287.1"/>
        </source>
    </evidence>
    <sequence length="847" mass="97154" checksum="E1A173D187A77331" modified="2025-10-08" version="1">MSHSYYNRQWQEAQAALVDLLQQENPPEPPKPERDRLAAFQLLATMYIKYIQIFRKLEQSYDQIVHPQKRRVLRHCLDGVMGRIVELKHEMMNLEFSEYHYFDDVLSDLKLTPNDVEIPIPKYFINERAKNLKEREKLLGQILAKIGPQDQDREKEEIRMPWEQAVRIVQIHERARQGRLRAKFMRDIRQQEDREKQAQNRGAPTLDPDVAAMRIQKVWKGFAQRRRTKRERDEEMIFIGMAPAPLPTSTKNLPQTFAAKTEDLRHKAQDVHEHEYQQALVNIRENIVQNEGPDMKETMMDQIRQWFIECRDATGKFPEYPDADDGGSAMIFKEKDPAELEKELSEKDDGKGKGKKGGKDKKKDKKKDKKDKKGKKGKKGGDDDEEEEGWKMAPSNFVPSVNEASDTYKGVWATRDETDNFPQKHDSELIKEEKRKEVEEEVRLSVDELMRAELSNLKAAVDREKKGKKGKKSGKKKKKKGKKSGKKGKKGKKKEKDLTPDRTMEDLYEELVTQGIIVRCPNIRLADYEGEYSYLGTTLRQANIEPMPSLSDVRRLVTEFGILPLGSPAVHENCPLTKSIMLAGPRGTGKKTLVQAMCTELGANFFDLSPGNLAGKYPGKDGLKMLMHLIFKVGRALQPSVFYIGECEKMFKKKIPKTDPTDPKRLKKELPKALKTIKSDDRLLLVGTSRCPFDGEMKPLMSCYQRIILIPRPDYASRHLLWRKMILKFGGQLTNYLDISSLSKVTDGYTPGHLVTAVQQVLTDRRIQQLAKKPLQAYEFLAPLARLDPIYKEEEESFKTWYGKTPLGKKRTKAAAADEDDGGGGKDKKGKKGKKGKKGKKGKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBN1</accession>
    <name>A0ABM0JBN1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (34-2'-O)-methyltransferase regulator WDR6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101852063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089954.1">
        <property type="nucleotide sequence ID" value="XM_005089897.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852063"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1046"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1077"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1094"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005089954.1"/>
        </source>
    </evidence>
    <sequence length="1259" mass="138069" checksum="938B87EFD4FD1B6B" modified="2025-10-08" version="1">MDIQLECFVGPVTSLTACANKLIIGCGSEITIFNLASEKYENTQQIFVGSSVHGLRAGLSYGNEHSLCVFGAKHARIVTLSNCDSEDKKSDINLVSDVFHAEDWIWDARWLCDQDKSERESDEYGTVALALAHNTVVHWNWKENKVSRTRHCTEKCILYCAHFIGDSWSDLVLAAGTVFNKIVLWPVGNCNSQDLDEPVDIVHTLSGHKGVIFSISFHPKLRKICSASDDRSIRLWKLTFQCNDFSALKPSDWNTMESTLLLCLFGHSARVWDVELMTTCFASVGEDATCNVWDYDGNIITKFKGHQGRSIWSLAVGEDEKNLFTGGGDGSVRMWSLEQGRDKQMSQTVLTLPSSAARCHGQEDFPRSVTLLNYNMVLVMMNSGSLLCYHISEQQFSELLSGADFHSYSVVSPCPDGRSLAVGSISGKLCVIKVLESGETVSCEKTVFSGKVLGITWIDVDCLVISGPLGYCHLLTVETSSPAETQGQQMSILTQRELSLPPSKHRWVTAACMVPLSDGPARGAPALMVCGDKDGSVHSYTLSPENTSDADGSQTTPLLPHQTFQKVHSKAGVTYVCYRDGRVHTAGRDGFYRQWEVKNGALSQLHGNKILKGLEWIDRLEWHNGDLLVYGFFSSQFTVWSVTYNQQIMSVQCGGGHRSWGCCHENGVLRFVYLKAGAVYLVDSERQTKQRIIRAPLHGRELSGATVIGFVHCQEGTWAPLVCTASEDTSLSVGVMRHDQGLVQWEPLASLKGHLSSVRCVTAVPCEGIHKLPPRSDLEWDHADKETSFVLFSGGGRAELRAWKLQVMPPMCRRGGHSYGGRVNVERVVSEATEEADVMNEIQTSRLTKHAVSVTETPSSIDCDKHGVSLSSVSTGSAVDPTLSGAGTSTSRSQQICSYKHLATHFLGECRHKQRSSSWKTRKLRLDPETRVMSVAATTVSQLEPGSQRDDTASGGHVSGLYLVSLAGSDGVLRVLLFDEATQNFSAVVQSSFHKGCVLKVTHHLQHTSDSQPTLLLLSASTNGQIVVWKLGQEVIQKCTNDRSLNHRGKVKTNKNPDNHCERGQQNQSKAGSCEAGTDEEEGDVSDDYTDFTRQGEDDKEDKHKDWQPLASLPAHQSGVNSLHSLQVSDSQFLVASGGDDNAVTVQLCQLSGVQVNLLCKVTQHRAHAAQVTGIKFINPSLVVSASIDQRICVWRLRCNGEKSMHLELVQCKYSNLSDVSFMDICQFSGSVHVLCGGEGLTLHTLIDGTEAITGQNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBT1</accession>
    <name>A0ABM0JBT1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850689</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090040.1">
        <property type="nucleotide sequence ID" value="XM_005089983.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850689"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090040.1"/>
        </source>
    </evidence>
    <sequence length="1358" mass="148162" checksum="6283678A87C8258A" modified="2025-10-08" version="1">MGKGGPVPAYYPSLGDILQPDAAMWNVEEAPTLDYMFDQSYRHHCWSSTDHEEPSNVCRDDDLTKESQEEEEVADLRSCSFPGMAADLNNSAADSSKISLSSLTPCSLASNYLTNGEQRGEKMDVETSHEERMEAPRETDETSNAVRTISESSSLMEVDDIRSSITDVIDNVADDGGGGGGGGGGGGGWSGGVYSVDGMVPVAADAAEGCHDDDDEGGDAAAAAVVAVDDVGNGVCRDGGAGADCCYVSGGRETPWEPGGAETLEGVENRNEKIPSAKRSLQHVKEHTGSGEDKDDISSEGSGSRVHLLKHRLHSALTLSDLSSPSAQGLTDVTKHQLSSSSVTVSKDPCHVISKTYSKNFPRQSASGSADATGRTMADVESIPRERSSGCTACTYSERPCHEPNSNEDVEYQSESIQVKLSHLNLCPLECPSMSTEAAESGLCDDLSRRSAGVNVAMISRSYQSNSNLMTTQNLETFSTTQTETIYLTPDLPKGQTFGAVHKVDGGENKDRNIATQEQVVFEFEATFMSGDIQEDKMGPFHDAGTSVFQEAGVLEGSKIQDKLSGLNDSQCGSVSVCLEQKNATVARISSCPELLICRDSEIYGKSANVSGDDNKLPVPALVDSDAYQGSAVRERTRVSHRVKTNHALSENLNSRPRSGHEGDFAEERMKGQVQTQLEAGDSTVDKKRASQSSDGIVEKKRKDTCSKSGRRSMSPGINARANRKQSVRDRSRSRERKKESKGPLGMPHLGSKYYRRALSLQVHSASYPVMQYSLQRSLTISSSNAQNVPSFTDSAATEKDVNVVDLGSMQEDMSSLGDIQQGRFASKTDNVSFRVGCPENGQVKGFQEKQSSFQLRKRVLSRQNTMETVMEQEVEQSPTITPQKISNSIDDSNAVEEKGTSVFAQYSLVSACAQVSGPHPNTIQSSDTVVKRTSREIGLKTVFHSPPKPSQRQGTFETNSFLNLRGKVCRRQKSSVGVKSTTSQTLVRKPNRLMSKEEPLPPVSLERWGFKTRHVGADPSCDAPTKRVNPKLSDHVNSIRCTKLKKKKSWVRAQKTSRAKTVVRFGHTSGPTTTENDNGKMGSDLNTVIRFPRTKSFTKRGNVPKVKNIALSNYISNFNMDQKANKITKTIRKAAEQFSRAEFSQKGDNRVNFPTNEGYLPVVQIQSFEAAAAPELSNGSDNDRDKRIIQDGVRQAATNPPRCEKQRPRNNIPARRAPSKNINQVQAVSKRPAAIYTERETKSGGDKAKKRRRGLWEGPARLHASATADCQIGLIKSPKKSRAEDLTLFPHRVTSTGHYYPSKNVICITVKPLNCCISRENLELQVRVHCQDHKPEATKSSNRRPFLPPGRRLKKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBT5</accession>
    <name>A0ABM0JBT5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin-G heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090049.2">
        <property type="nucleotide sequence ID" value="XM_005089992.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852291"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026117">
        <property type="entry name" value="Par-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15093:SF1">
        <property type="entry name" value="PRKC APOPTOSIS WT1 REGULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15093">
        <property type="entry name" value="PROSTATE APOPTOSIS RESPONSE PROTEIN PAR-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="451"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090049.2"/>
        </source>
    </evidence>
    <sequence length="528" mass="56684" checksum="5A86A0D1FB12034D" modified="2025-10-08" version="1">MASSSVSQESLDMDDFDNTARRNRIRVHRGHSGRGSLPYRTLPDRGDGVDQDREGRGGDHHNGDVGDGGGGGLGLSSHSHLPGDHESPTRGAAARLKDKRSRANHMKGKLPKDKRKLREKRRSTGVVHCMPSTESTGDSLDDEDDDEDVSHDTKRNTTFNEGGSAGHHHHQTLYETRHSASVAYSHQRRNKSPSDLEADLEDNQDYDSTVSHSETNLTLIGRSESSDMSQNLPNRPLCAAGTGLGRFGGGVGITSKFSPESNRAAFKFNPSNMSSDADSPRTNTPSTSSSSSILSRYREMDSPHTTTSSANNNNNTSTSSGPPDPDSPRRFNNNSNNNNNNSSSIGGGSAGSTSSSSTLSSQIQPRPVGFSVFRDRDSTTATSAGGGVLGSSSSRGDKPPYSSSLVGSRFGRDRDGGASGAAGAGSAHSRLASYQSPRPFVSMSSSSAAMNQQQTETISQLEKQLDKEKEENKRLQQQLEEKDKKIAELEKAIELLNTECDGLDEDNLKLQEENKALIRAMSKLTTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCC3</accession>
    <name>A0ABM0JCC3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hematopoietic prostaglandin D synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090419.1">
        <property type="nucleotide sequence ID" value="XM_005090362.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858823"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090419.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17203" checksum="3AF2B7E8884DF6F3" modified="2025-10-08" version="1">MSSSKVKIFYLDYMGRAEMIRLLFAAAGKPFEDIRIADQDWPKWKPKAPFGTVPFVEVDGEVYSQSIAIANYFAKEFGFFGKNNKEALLVEQMVNLIQDFIQVSVVIEEQQDQKKKVGAYLKSITQSTLLPFFFYSRCRQQISSFGKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCP5</accession>
    <name>A0ABM0JCP5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101851996 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101851996 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101851996</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090647.1">
        <property type="nucleotide sequence ID" value="XM_005090590.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090648.1">
        <property type="nucleotide sequence ID" value="XM_005090591.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090649.1">
        <property type="nucleotide sequence ID" value="XM_005090592.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851996"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021068" evidence="1">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005090649.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12881" checksum="B0419C8CA03061BD" modified="2025-10-08" version="1">MSWTCERLWLLLVLLVPLCLSLRYTDYMTSPEYRHDALKTLRNIKKRLQPSMSVSRRSGYSEQKCRLWNDPCEPWTSDPSRACCNPRRHVCQCNLWLQNCRCGTRLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDA2</accession>
    <name>A0ABM0JDA2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101862992</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091057.3">
        <property type="nucleotide sequence ID" value="XM_005091000.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862992"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="490"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091057.3"/>
        </source>
    </evidence>
    <sequence length="628" mass="72411" checksum="04E28641769185C1" modified="2025-10-08" version="1">MPTLVTKNAFGPESAFQPDMSGLQALTATPPRHMRDVRAAMQRELKSLTKLLQRVEKAYYGERGNINNEVEHYVYSVKMLMKSLMIFDLNNTAAVDDMIKLASNPSRYTGEPKYLKDLKEIYIKVQTFLPDRLSEIVDRCQTLLDRVHRYCVSFYDPETDCYLETADHYSEQIGSWIERAQSSIQSVRSLYQRFRTSGVTIKMLSSPVEKFASRNSLQRVLFVVLFADACTHLRNVIEVMRAWVKADENYSSYVKNDLNELDSLKEDKVRDLRECRQKSHGLTYKLTQQEVDYSRLAADVNSLREKEGSLRIEEVHLANLNTDTEREIEIKERRRDQLRHQSPVHGPAPSPEPNVDTVESLTHEIKALKEKLPLLARQIAAVRLKRTWIDDKMGALDRLSHGMLETKRELKQVDIDRARREKEYSEVERAVDVAKRVLMCKTASDSVEKLYYKVPMAARAARVVKSKEEGNIADPVDRACAIICKRIERDWTALYRALPFHPIRGSETISQDIVDLTQGGARGAYALVARRALDRWRRYHTRSSVEDLRQALRKIRRLDILKTVDLILTPPAKVITAPFEVVEEPAPPVEAHLIPFYKQIERYDQIRANRLAAEAEAERRRMAKLKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDX4</accession>
    <name>A0ABM0JDX4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847792</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091451.1">
        <property type="nucleotide sequence ID" value="XM_005091394.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847792"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046647051" evidence="2">
        <location>
            <begin position="27"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091451.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41331" checksum="9F6DC149692D728A" modified="2025-10-08" version="1">MANNKQVITVVFLATSLFLAQRYARGESCRTNLGPGCLCIRERATVHVTCHTLAQWTRPLDEWNGVEKLVVICLGEEATVSLEHPLAANLTALTLTSLEVHDCGLRDLGPWAVDNLVRETGLQLDNNRLSRIPLAVRTLALRELYFYDNPITAICAGELPDTLEILRLEAADLRYIDPDAFAKTKRLKVFRVPGAKGLHCIHPGTFANTQLRQVDVSDSGLTSLDFLLSVDNNWGGQELPATRIEAGGSNVICDCSVKEIAFRYGDALNVDCVKELRDGEAFKIKKGKASSWEMKFANCPTDTPTNPPTVANGCFRQGMHERSECKRWQSVPFRVGEIKEDPYLALAGEVRHQSTFILVSLLLFIVWMDFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE51</accession>
    <name>A0ABM0JE51_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091618.1">
        <property type="nucleotide sequence ID" value="XM_005091561.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845981"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF26">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091618.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="27916" checksum="E6F60C6D6ED90C96" modified="2025-10-08" version="1">MASVESNSNDGVISKQLLKSKSGEFDVESIHTLNIKDAGISDVGCIGECTSLERLDLSYNNVSRLHKLAGLSALVKLNLAANRISSLEGLQSLENLQSLNVSGNLIGSVDCLRYLAGLEKFTSLRLQDPANGLSNPMCNMSYLDGVLMMLPVLITLDGQRVRGRGSELFQLCKHMDQAMYNFKSVNASSMPEVGHDATHDVDSQQWMLDIGGEAKVQEAEENLRAMLDGCKQLSNKAALVLYDSEEARPTDTSEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEE5</accession>
    <name>A0ABM0JEE5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101852752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005091812.1">
        <property type="nucleotide sequence ID" value="XM_005091755.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829770.1">
        <property type="nucleotide sequence ID" value="XM_035973877.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852752"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014:SF4">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25238">
        <property type="entry name" value="OGFOD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="211"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005091812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035829770.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40091" checksum="5E228B018C2384BA" modified="2025-10-08" version="1">MLLKGGQEYICSCFFKRNIFLKRYKMHVTFESQDQFQDQYRQLLRMKGCATEKQYKDVLEQITSEIERRRALHKLTADRTQRFKDTYIKLHPDIWILKEPFLDSRFFSIVADAQSKSLDNLLFSILDNSGNITEMEVYQFPVFSSDMCKLLIEEIENFESSPHAKTRPNTMNEYGVSLDEMGLSQGLILPLIQKYLLPICASLFPSWGGGTIDSFKAFSVKYEMGNDLQLATHYDNAEVTININLGDKYEGGNLQFGRIFGDEEEYEGKGEESYTCDHKKGHGILHCGRRMHSALPITQGMRTNLVIWMRSSTVRNTQCPMCLSHPSLHEVPAEGEGFTIQSPWSCSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEM4</accession>
    <name>A0ABM0JEM4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Receptor for retinol uptake STRA6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101848723</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005091980.2">
        <property type="nucleotide sequence ID" value="XM_005091923.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848723"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF16">
        <property type="entry name" value="RECEPTOR FOR RETINOL UPTAKE STRA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0683">Retinol-binding</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0845">Vitamin A</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="583"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="644"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005091980.2"/>
        </source>
    </evidence>
    <sequence length="782" mass="89785" checksum="D0D50B82DFCF7C31" modified="2025-10-08" version="1">MSEFSDSLKYAIDLISNYSRKHDYESLECTGDISYFQSIQYMLIPALLVSIFYAFTIRRKWIWPEKLDGRPGIVYPMSILTRSERISYAACFGVIATFVSKIIFESKQAFDYTGPTWGKAFVTVLSMFIYGLNCFPLFASVALRSVLSCAVGSVYTWCFSVVIVYTFFTCDLSPEARVAYFFMSGPQLLSLAYLCLRLPYGFVVTFRIWLRERRCEKVKFRESLTRIRKSYQGQRVTQLFRKPPEDKGKKDQDIVEKIFTSLVNFLKSWIYNWQPDFRYSARILAIMWVGFAVLYMTMFKITWSSTSLFLYLVDVATYSLDSIGWSDQAGDSDVIKLARILLKIYYYFIAAIFVLAIICYIVAFVIGLCSILYSLSSYRHNLRALHKGDYSHVPPRGKMTNVSLLTGSMRYAGYQVGYIAWAFVLQALSFFTFVIILVLVIVIIALGFSEWFKSLLQYIGPWVFVLIIFLVGQYFMARLVFLQSHKDSLSIDNRRGLFLAAYFLFFYNVFVGFASCLLRLFKSLVLGICLISRLDHSILPHKFELSDNGFERYVGFLHLENYHNHPVQHVFVHLLQHSAQETRHKLTSDTTSQSTALDSGQQKQSSKGLLHKGNKVGSFVGSSKGETDMGQIEVKESEAVEKGVDYQLTDQPSDELGPAKRLFTPRQDQRDEQPSVNGEIKDPEVGSSGDVSAQWEKVKDSPELVRHRKRQLAAFQWSLAYTLFSNPQFILERKGFIQQRMKKKGGESVEKKDEDKEIVKGGLNLEMLKLSKKVKKTEQTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFI0</accession>
    <name>A0ABM0JFI0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Scaffold attachment factor B2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101848418</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005092497.1">
        <property type="nucleotide sequence ID" value="XM_005092440.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848418"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12679">
        <property type="entry name" value="RRM_SAFB1_SAFB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051738">
        <property type="entry name" value="SAF_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034781">
        <property type="entry name" value="SAFB1_2_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683:SF8">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SAP" evidence="16">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="417"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="47"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="317"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="491"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="698"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="934"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="525"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="698"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="723"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005092497.1"/>
        </source>
    </evidence>
    <sequence length="955" mass="106396" checksum="3ADFA07C62580057" modified="2025-10-08" version="1">MATAEKKKLTDLRVIDLKCELEKRNLDKTGVKSVLIERLQKAIETEGKDPNSFEFEVIETPKKPASAGKSKMEENGDSNTEKAADEEELLAIEADQVNNAGDAMEEGLPVQDKPLPQPDELNAEDKTGTIGGPSVGQEEVPLNDENDVEAAAEDEAALMDDANVPDELMEVPEEFEEGDEFDVEGNPDDEALDEQPDLLEDPVHSTEDSGATNIIAETVERELAKEEPLLAVAEPSSTDQKADDPVSAEADSGSAGENNSSSLSASVATPTPKTPASAGSANVPAVPSKGENASSGLYEGGDDSFVVQVDDTVLNDIDSDLLDSTQSGDGKPAEAAPADGVVSQAEEVKKEEPAASNETSTADPEVAAAKTSEKTDPKDTASKQATASKDEKDGKTAVKSGPAKPVKKDEKTSQSSRNLWVSGLSSSTRATDLKTLFSKHGKVIGAKVVTNARCPGSRCYGFVTMGSADEATKCIQHLHRTELHGRMISVERAKTEPQGAKAVAKVLPPSGIKSPSKPNSRPVSRRSDPKSAPARKEEAKEGEKKEGVKDKEPGKDTAEKDGKEEKGEESRSHSRHRSNDRRRSPSSDGHRRISRDRSDLSDKARRELDVLSFEKIKAERDRMRLRNKEMFLRHEERRRQLGIEREHYKQQLVEKRLGEEGLKLERERRRLREMREELERERMETERLKLETERLQIEREQESYRREQQRVLQDRRPLKRHLDRGSRDEEWSGSKRPNERYQSDGRPPRYERKAERFERREQERPPRYENRREERPARHERYEERERGGREREPREREYRSREDHRSGYREERPREPRSSREERVSGRDSARGPQRHESRSEWKSERETRGGSGGSSSIWNGPVDREMESGWSQSGMTAASLTPAEGWESGGVVMSQPGGSFTMQQGPMMASGMGAGPVFIAQPAMQGPPVMMQGSLSRQGDGRYSMTTSTVRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGJ2</accession>
    <name>A0ABM0JGJ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2 E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101849037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093186.1">
        <property type="nucleotide sequence ID" value="XM_005093129.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849037"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="66"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005093186.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="22949" checksum="AA2FFACD4B2ED822" modified="2025-10-08" version="1">MSSPSPSSAQSGSSGVGNVTEGQARLQCVRMSDPAARSRPGIPDGAHSSAASANKSSAKSAKNLSTSGRRLQRELAEITLDPPPNCSAGPKGDNLYEWTSTILGPKASVYEGGVFFLDIQFTTDYPFKPPRVIFRTRIYHCNISSQGAICLDILKDNWSPALTISKVLLSICSLLTDCNPNDPLVGSIAQQYLTNREEHDRTARQWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHU6</accession>
    <name>A0ABM0JHU6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GPI transamidase component PIG-S isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101850546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093987.1">
        <property type="nucleotide sequence ID" value="XM_005093930.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850546"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093987.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="60932" checksum="9DEE4178441764F8" modified="2025-10-08" version="1">MAVDAVTEPEFGEKRVHHIAALCLGIFCIVVGVPLWWKTTEVYRVSLPYSDIQHLSDTKIEYLTQVEVVWAVNKDVGSVFLSDLAVQLNRQLEKKDQPSLTSRFEVIVREAEKAELAALEKIGAVSDLQQIMPSDALHKYSVIITKTSSLLSQPILALNNNIFLPYNGAAESALAAQITQLLKDVMRESTVVKNLEAARRMKIERPDKSSMRSFRFHPGYDVTFTLMVPEPERVRVDWDIETGIKDYLQPLKASLDEYIDISISSQVLYFIGIGGRPKKGDGFYFFQEQDLPHIINPLESKLGSHASNNPGMNFIVYIPTVNKRPLFIHDNKGVPVPSNSFLSPRWGGVMIYNSESSGVNSSQPDSNVNVDMHKVMEVFISQMRLLLNINAQLMTEELLIVQTGSARLQQWELSAWLRSRCVENLAAATLTLQSLAQLLEEIGNIVINDEIGKEVESAVASIKDSQRQLLLGDLHAAFLASRAAVEASELAFFHPSLLELLYFPEDQKFAIYIPLFLPISIPILTSVLHAIKFFRRPPKIKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIP9</accession>
    <name>A0ABM0JIP9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094551.1">
        <property type="nucleotide sequence ID" value="XM_005094494.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857708"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005094551.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19046" checksum="73BDA0205D025BC1" modified="2025-10-08" version="1">MFYHVSLEHDILLHPRYFGPNLLNIVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGLIQPSRGFVVYPVKYKAIVFRPFKGEVLDAVVTQVNKVGLFTEIGPLSCFISRHSIPADMEFDPSSNPPCYKTKDEDMVIQEEDEIRLKIVGTRVDAKDIFAIGTLMDDFLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJK6</accession>
    <name>A0ABM0JJK6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101856332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005095159.1">
        <property type="nucleotide sequence ID" value="XM_005095102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856332"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005095159.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27300" checksum="BC293BE7AC54B3EF" modified="2025-10-08" version="1">MEIVDQRDDIFDAFNLVRGPLLGRGSSGEVVLASAKHDMSLKMAVKIISLERQQWENQFDEEVTFLRQLRHPHILKIVASSWNAAYGFIVMNYYQNGTLYDTMSGPVKGPRMLRHTLDVDRAILGDFGLAIRLRDSETMVVEWVSTPGFYGPETPMCPFKLDMYSLGITMWVLIYKRHTIDLDPLASTDNCSNIKEPYRRILLQLLHEEPRQRWSAADLLRFSAWNSLRAPQQLSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJX1</accession>
    <name>A0ABM0JJX1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101852615</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095398.1">
        <property type="nucleotide sequence ID" value="XM_005095341.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852615"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="688"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="860"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095398.1"/>
        </source>
    </evidence>
    <sequence length="1178" mass="129931" checksum="EE7A5E3396C7362B" modified="2025-10-08" version="1">MTTEVDVAPPLVPPLDLDITAPPLIMDSIVTDSSNSNNNIYNHTVDQALDGDTADCGKYMDNENDDNNENDNNNDDDEDVDDAHIGDEDDAHDEIFGQRSDSDSEMDSPDDFSAVDSDQIPEAATIRHREPTSESDNKYSAEHTKTVENAQKESNITPAENFNTSETDTEVNQSNAIVQSTIETENENPATNESNPHGTDPSSDSEPAVIAQQDSSAIDTEPSCLSNNSSSDGSNTTVPPAPENFPALGTAVLADKMEDGDVSKQTGLMDSIQGIGLTDLSRLKGLDKADPTVRRLFVRPRVTTRELMSLTIDPDIKAVVDEFLKNNIVGNFIIARVLRENYALFYSWLSTHIQSERNAWAVRLRQALVQAEQHRKDSIDISDLVVHSAARLRHLVQSASNTMFGLPTKGHHHHHHRRGTKSIRSISQRRQGASTTKSVASSSSGVSSNAHSIPNINGRDAKDAKSSTGLYPFSVDMDDKTMATAYQNRKSNFQNRLMAMSRLNERSIAAMAGNKGLTQSSFNVVSVVDTSRVAKNPEAEASVRASESEAETKDDATTSGNGKKPKPNVKIQQNAPPNWRHGGGVHVGKLKKKGNHPFEYNEEEFKALYADGGDETDDVVVGYDEEETDWKQVLRDNIEVLTDICDTLVNDRTECLRLVGVKPNAVASLVEAVSGFVKDRHYSGHNKRKEIERRLGMLEAENKNLQNEMTVLQNTLKEKNNDALNLQRQLDKVENMLKDNMNSKVHKCVGTDDFLSLKTLHKNGHKTRKSPAAFDDKNSNNKGPLTNGVGLKIPVGDMDEAGLRLESKQILRSVPAEQEVKQSGKSTNETPVGNITEKQNINLTAEVDSGMRPTREPSLIEISEEKLKTLKQRARKLEDSLHDAITSMEKLNKVTPHDDSASMHSTTSGSTITSILVKPSRSYMPRHHHHYWKKASLEVNGVAPESARIPKLTVIRRPGFISERRCQSEHPPSITLESEHTSFLEGKSVVQAPSDGSLSHRTPAPHDVPYNTPIPSTNMRNLGDRLNGITPLGVTPVSRISQTVDYTSGEENYFSEDNFRDDELSDTPRRKGKSIAGSNNGGGGGEKWASSSTSTSKRKARVISRFRPTGGGMVAKCLRCQKLFSSVDNHKLACCYHLKGKERLEHYDHCGRLLRVLYAWKCCRQPQDAEGCCYGQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMF8</accession>
    <name>A0ABM0JMF8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097130.2">
        <property type="nucleotide sequence ID" value="XM_005097073.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861580"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097130.2"/>
        </source>
    </evidence>
    <sequence length="273" mass="28904" checksum="FC1208E67C22A16B" modified="2025-10-08" version="1">MEKLDLTGRVAIVTGSSSGIGLATAVLFVKRGAKVTLHGRNLEKLSAAAKVLREAGAKEGHYLTVAGDVTEPASRESLVQQTVGKFGRIDILVNNAGCGSRAFLRDVTEEEIDGMVNQHFKAPVFLCQLCLPYLIKSKGNIVNVSSCVAVEALPGSLAYSAAKAGMDMFTTYAAVELSELGIRVNSVRPGLILTPIFDSVPKEICDKLFAAGRRRALLGRNGQPEEVAEVIAFYASDAASFATGDCPVVDGGRSKHENSGATSPMWPEYGDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN72</accession>
    <name>A0ABM0JN72_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859634 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097639.1">
        <property type="nucleotide sequence ID" value="XM_005097582.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859634"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045115830" evidence="2">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097639.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29111" checksum="85DABE141DD3C65B" modified="2025-10-08" version="1">MWARFLILALASALLIVTSAEPGLSGRKTGLKPVLDKTLSTETVRDVGENGTNDDDDDGVYDPDTVVEGIRLGDLSPKELYLLLDDVDNAIVSELDILVLKKQLEERAASAATSRSAEDSAATSRSAEDSAATSRQAERPSAHQDDEAGSTRKKRWGRLASAVRGIFRGSRRAPRPTRSGTRVTREYNRRGNYQDAQRHFDRLNPRDQSSFQGQISGRSGRLGNHRVTVRDGSSGANSRPTLEIRTPRPDGTTYVRKFRYNDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNG4</accession>
    <name>A0ABM0JNG4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097806.2">
        <property type="nucleotide sequence ID" value="XM_005097749.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857333"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005097806.2"/>
        </source>
    </evidence>
    <sequence length="299" mass="33267" checksum="28EA19535F65FF85" modified="2025-10-08" version="1">MDNDGVLSHFKEQLREDPEMSAAVAAIKTLVKLIETSRAGTLSELRDNIKNATEVMLTGEYSYASVSSGCEQFLRNVSLANLDRNFKTVMLERANIFLKEILKARSKTVQMATRFIDDGATILTHCRSRVVMQVLKAAAKENKRFTVYVTESNPDQSGYGAQEELTKHGIPTTVILDAAVGYIMERVQLVMLGAEGVVESGGIINKIGTYPIAITAKSMNKPVYVVAESFKFVRAFPLNQKDVPDHFKYPQSTLRAQKDLSKEHPLVDYTPPEYIDLMFTDQGVLTPSAVSDELIKLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNI7</accession>
    <name>A0ABM0JNI7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein MDM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101847338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MDM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097852.1">
        <property type="nucleotide sequence ID" value="XM_005097795.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847338"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029136">
        <property type="entry name" value="MDM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32078">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32078:SF1">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15501">
        <property type="entry name" value="MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="529"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="716"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="571"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005097852.1"/>
        </source>
    </evidence>
    <sequence length="813" mass="90603" checksum="5A51B3B0D624AD6B" modified="2025-10-08" version="1">MPVHFKGASEYKVHYKWMDSFRSKSFQPSQEQAARRAGQISVNSSLTVEPPLQHKKRLEGPPTSLSTNYFSVPSKEMDYALLGQQEKFAPNVRYQPKPSHSGQKIYKNKENFDNAPPPSKQLKMQKRIKPLFKERHPTVSRSPPRQAPTTSTILSPPPAPRVPKESLDIKEALRDKDLKDVLGDQAPPPKEAGVKTRESDAQLEKGRGNNMNEFVQTNMKKGVALSGPEAPAEYALKYKAGVAPPRPVKKFSEYQRQFQWKDGMKASPLLAAEEIVYKSNAELGPYKTDAIPKLSEYRQQFQKWKAPDFAADVNLNVSEKMATAASQQKQEKKRTVAKRSKSAGAVLHQEPEEVDDEMGAEGADSEEQLKTKLLKSHGKIKRLGSEYKANFKSPLRYSYAEGAWRGAAPPQMMPQTSSAENTDANNDKENNNNNNASEEAPLSNWFAEVLELRRRAQEYRKRAQGTHFSREHLVQLMAKQNECWDLHSDGSSTVRALNLETSGAHLRGKEKNLAQTAPADLVDALSHEATEGDSPLMSDVEEAEPQRKEGKKKKGRRGGKSKGGRKSRKMAWLEEQKESVAEQRRQLEETRQREDMKDDDDNDSEGLVGKEGRLPTPLLQGDSSARRHHLDLTTPAVGGAILTCPPSKSSKLIITSRSGDSYVTASDDLPVRGEQKKYNMDKLLTLPAGGKPSPDTHALRDDVAESDQALVTQYIVSPPLPGSEEDKENKGQRKKKSKGQKPGSLTTIKEGYGKTYQPKPFLDLDDIKAGTLDKKDDDVLSVSLMSVASSGSLASEVLERARKRQEFWNKKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNX1</accession>
    <name>A0ABM0JNX1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101845771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098094.1">
        <property type="nucleotide sequence ID" value="XM_005098037.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845771"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04751">
        <property type="entry name" value="Commd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037355">
        <property type="entry name" value="COMMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31159">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31159:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="124"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098094.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21521" checksum="D3D221CF85EB6F90" modified="2025-10-08" version="1">MELGSSILENISVAGDAAHISDKAFISLVQAACQGVLLEEHRNAVAENPAFKDTDKAILKEAYSGLVTLILEAAKHDSSEQNISSVLEDCKFTTDRISSFAKEFLPQKPHVQLLLGKISSSFPHIVDVDWRLDYYIKNNHLEKVNSAVYLISLKTEVPGSNDIQEVQFSCSLEQLQDLVGKLKDATKCMEKLTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQM5</accession>
    <name>A0ABM0JQM5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB/POZ domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101857118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005099254.1">
        <property type="nucleotide sequence ID" value="XM_005099197.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857118"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18488">
        <property type="entry name" value="BACK_BTBD3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18282">
        <property type="entry name" value="BTB_POZ_BTBD3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049737">
        <property type="entry name" value="Btbd6a-like_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="102"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005099254.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="56779" checksum="48BBA077D828208F" modified="2025-10-08" version="1">MKSCIPAKEKEEEEMNQEVPPNFIPSRQPSSILPNSSQPLSTRQGESSTISWQPTSAPRRVSPPPPNPPLPSSKLSEQHNWQASVGSCRERNSVMYNNSLMADVYFTVGTGPGQKRIPAHKYILASGSSVFYAMLYGGLAQEVKVMEIAIPDVEPAAFLNLLRYLYCDEIWVEADTVLATLYTAKKYIVPRLASACVRYLETSLSARNACVLLSQGRLFEEVELMQRCWEVIDAQAEECLRSEGFTDIDRRTLETILSRETLNTRELCVFWAVCRWAKAECARQEQQPTAENQRAALGSCLHLVRFPAMTLEEFANGPAQSEVLTLQECHDLFLYFTARQWPKLPFCKVSRKGLSQFRVHRFQSSAYRSNQWRYRGRCDSIQFSVDRRIFVAGFGLYGSSNAASEYKAKIELKRNGTVEGQTVTKFRSDGSSNTFPVLFESPVQVEADTFYTASVVLDGPELSFFGQEGVAELQCGKVTFQFQCSSESTNGTGVQGGQIPELIFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JT73</accession>
    <name>A0ABM0JT73_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101851420</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101851420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100929.2">
        <property type="nucleotide sequence ID" value="XM_005100872.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851420"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005100929.2"/>
        </source>
    </evidence>
    <sequence length="294" mass="32236" checksum="21B0F24663221B3E" modified="2025-10-08" version="1">MSARHPDELVLCLCLEDSAQCDVVIQGISSGHVFGPSQPLHLMLCGSNTSDLEGLRMDIEDCTFPLVKGTSVVNSLSGASVTPHVVMVFLSQREARDHSHVVQFGQLPRLIDFITDISDILSSSPALCDQKVLIVGDLALTASSLLSRKLKCLSSSQLLAIDSDEPSAVLGRESRRPKTSQYGLLSRLCTTVSHWWTGPQEKRHITINLGTKFLDTKQRSSSSSSSSLPSFSGYFFSTPVDIHSPQSFSMCLDKSVSIDHIVRCKEEQDRAIRLLASVDDQQREAEGYVIEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTG5</accession>
    <name>A0ABM0JTG5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUAK family SNF1-like kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101083.1">
        <property type="nucleotide sequence ID" value="XM_005101026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847883"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005101083.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36180" checksum="648D714647B7B0DE" modified="2025-10-08" version="1">MSTKMNFQPWECNVASVSPEQALGLKRDGNIALGFYCYVIRVADVNDPSRKMAFKRLKFLEDENGYRCQRFLFYNEVRFLKNVQHPNIIQVEQALVCPGEFVIVTEYHPTNLFNDLRRHTQAEVSKYFSQVVDALLYLHDRHIVHGDVNLQNVLIDTQGNAKLCDFGMAQFVPNKSSKHWGCYSTMYYDGPEYIRGRPVEDAFKLESFSLGVCLCALSLRVYPRKDLNYLELLRAGESVPDIHRVCAERLLCPSPAERASISEIHQRLNDHRQSESRAQSDVIHESPAPVSVPTPCECSHVTEEYRNFILEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTN6</accession>
    <name>A0ABM0JTN6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101845626</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101241.2">
        <property type="nucleotide sequence ID" value="XM_005101184.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845626"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101241.2"/>
        </source>
    </evidence>
    <sequence length="317" mass="35643" checksum="1B31E3AD828A79EF" modified="2025-10-08" version="1">MTHFICIHFQVWTILALVACGMFLGFPQGSDTQTQTNTSNSLQRNVTLVLEMPMIGYAGLLQNKSFYNMLFNDLTNSIWTAWKEETSDVTILSIAHRLGNLQVLTSVSIIKKNANPDPEGAFAYALLTMARNGFVFQGTRIPWVRYNGYTVQPTLDVCAARQKMDPCLQKDGKYCNPFRRGACVFYEPINDRNEEDMYVVAAVGGALLLGLMVLFCVCACRKCSQSRRAKKYREGRERFWSTTDVPDRLGCPDTIVSTCVGDTNTNRGTRAEETNRIAWVEVESLPTFSTPYGSRGRNSGGPLNLFRDVPNWTSERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUC3</accession>
    <name>A0ABM0JUC3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Iron-sulfur cluster assembly 1 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101683.2">
        <property type="nucleotide sequence ID" value="XM_005101626.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849853"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101683.2"/>
        </source>
    </evidence>
    <sequence length="130" mass="14349" checksum="96B4A935561E14A5" modified="2025-10-08" version="1">MASRAIGRATVRAVTSKRLTPQKAPLVLTQNAVNKLKQLMQDRPEMKGVSIGVKTRGCNGLTYTLDYSDKKGKFDEEVVQDGVRVYIDAKAQLTLLGTEMDYQEDKLTAEFIFNNPNIKGTCGCGESFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXM3</accession>
    <name>A0ABM0JXM3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101854968</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101854968</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103937.1">
        <property type="nucleotide sequence ID" value="XM_005103880.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005103938.1">
        <property type="nucleotide sequence ID" value="XM_005103881.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854968"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005103938.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16574" checksum="7D5C7D4DA7B399DD" modified="2025-10-08" version="1">MVRKHLVALDGKFHAERAFDWYLENFYRDGDEVVIFHCSQFELHVGLPGMAVNVEAVSKQVTQAKDKAEAITQKATETLRLKGIKGYVVLKSGSKPEDLINQVVDEENVNHVFMGTRDLGSIQRAFVGSVSTAVARSCKVPVTIVKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY42</accession>
    <name>A0ABM0JY42_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101853874</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104280.2">
        <property type="nucleotide sequence ID" value="XM_005104223.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853874"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047081298" evidence="1">
        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104280.2"/>
        </source>
    </evidence>
    <sequence length="196" mass="22665" checksum="815A50FAF1413C0E" modified="2025-10-08" version="1">MLSASQLLFATALVVCFVSAHSYCGVTPPVWRNENMTCPARAVCADVFEHVRDWYNGTRCEERRTLHNCKCQGNTVCPYNNDAHKIYASKKHTRYTCEPTCTLPYCSNVPRQLVRNRMVPPTAVTAEQNSAQFGGRTYYRIDCRCPRHHNPRQQRGRFRSVKTYSHRYDFRLHQYSTLYICDAQGSEGRLPDPCEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ68</accession>
    <name>A0ABM0JZ68_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease P protein subunit p14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104986.1">
        <property type="nucleotide sequence ID" value="XM_005104929.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857585"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104986.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14152" checksum="CB1813DCA4E13591" modified="2025-10-08" version="1">MRMPEAMSTTSYRTISVNSQPYLYLRIQLTVEGEDADKITPVQFKFLIVQALKENMGEVGAATPVDVLKLLGQGIALLRMPNRNAERLWAALTLYGRTPSDKRCAFRVLQVSPFLMGLAFDSREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZM4</accession>
    <name>A0ABM0JZM4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione hydrolase 1 proenzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105282.1">
        <property type="nucleotide sequence ID" value="XM_005105225.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847060"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055262">
        <property type="entry name" value="GGT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105282.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="62746" checksum="2B1059560ABDAAEB" modified="2025-10-08" version="1">MTQKNISTRPIVIAIIVGAIIIGVGLAIGLGVGLRDSDDDVIAPVANGEKYKSSTGTFQYAAVVADSEVCSDIGNDVLARLRGNAMDATVAALFCTGLLSAHSSGIGGGSFYTIYHKSSNTFHNVDSRETAPAAATQDMFQSEEDQPKSRLGGMAVAVPGEVLGLYEVHQRFGTVPWKSLVMPTVKLCEEGVPLTEATHNALDSIPDKTKFAPYFNPDLSPKAAGSLIKLPELARTFRTIADDPFSFYNGSLAADIVSDIADEGGIITAGDLANYTLTPSTPTNMSLPGGYQVFSTPPPGSGLVLSYILGILSGYNMDPSNIATTEGEILTYHRIVEAFKFAFGKRSELGDDLFHDNSENYVNMTSLADCEKIRQRISDATTHDTTFYNPTFSVANDSGTAHISVIDGEGNAVSVTSTINTYFGSKVRGSRTGIVFNNEMDDFSTPGTVNYFGLPASPANFIQPGKRPMSSMCPAIVWDNNEQRVKMVSGGAGGSKITTATALNIIDVLWLGMSLPESIDKPRLHHQLVPPAVQLETTFSKVIADGLKAKGHTTQEQFGKSVMQAIYVRDDGSIVGTADYRKGGIPKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZQ3</accession>
    <name>A0ABM0JZQ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Protein FAM43A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101858052</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105333.1">
        <property type="nucleotide sequence ID" value="XM_005105276.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105334.1">
        <property type="nucleotide sequence ID" value="XM_005105277.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858052"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01214">
        <property type="entry name" value="PTB_FAM43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033930">
        <property type="entry name" value="FAM43A/B_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF2">
        <property type="entry name" value="FI05246P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105334.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46797" checksum="DC86B49FBCCDE007" modified="2025-10-08" version="1">MNIFGWRKNLNISEQDPTHKVRYLGNVQTALMKGEGCVDKAAAVIWSNYMRSEHPGIEMKVVITGSGMKAYTKEQGLTEYRAHRISYCIAHPDYPKLFVWVYRHEGRKMKMELRCHAVLCKNEAKAKAMALQLHEKLSFALKEFQREKIRKQNSRLVLQRTNSLPKTGSILPLRTQLLSTANNFRPPVSKSHTAPKLGAITEDAEEPEEEFVEEEEEYEDEEAVNQHMVSTKTSVSDEEDDEEEYDENLPPTPVSAGPSPPRLLHKGKEHHDILEALNLQSGDEFLLAQPIIDLEVGNDLDELRRDDGVRCCLHERTDSDEESAESGFHDQDTGFPEQDPGFPEQDPGFPDHDDVRDGGEASGKGKGNMKAKRMGGKDERNGVDEEEFKDVCHYPSLDGEESDSSANSVSEKTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZR6</accession>
    <name>A0ABM0JZR6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 341</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101845946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005105369.1">
        <property type="nucleotide sequence ID" value="XM_005105312.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845946"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="849"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="877"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="905"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="933"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="369"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005105369.1"/>
        </source>
    </evidence>
    <sequence length="965" mass="108810" checksum="ACAA05CEF9057ED2" modified="2025-10-08" version="1">MSSNLEAPEAEASQLVPDFSQKLVIDETVGAESPPAATGVNSPSGEEVQQHDPSGQDVLQDLHHAESGSSQPVALGQAKDWSESSVSDVPQALNYSETNNSLSVAPDQAVICSESSMSGIPKDLDHAILNNSHPVAQDQEGRCSESDDVQMVLASEKAAAVHPSEQGKKDEHGKANFTCPCGESFEKSVQLASHRRWSCKLKVNVAQCSLCKAWFASEGGLGRHMKHVHGGVFSCDKCSLRFHNKIQLTRHWMEAHYSDVEASQLKCYVCQREGFGSKFELHCHLRDHRIERRAKRRSLSVTDESESSLRGESESIREFAHPLHHHWGDPPPYAPHPHHHWSHKRPHWRRHQASDSSFPYPGMQFCRPFFHPPPPPPPPPPPHFPPPYFYPFQGGGPSGNDSTLSGDGQSSNLRSSQSIPNPHTPDDVRPRHDHELPPTFHNQHLWHSHFWKAFRRRGHHHHSRGDGFKWKKYLKLLNMGESGFAPVPHWRKAFRSEQLAADENSHLIKVPCEFCHKPVEANQMGRHHRKECSGLLLHRCCVCDRTFRKRHFLIKHMHEEKHYFLPKQQAPLAGRGSPSTQATDSLSLSQLQQRLSSTLSLKDTKTDISSNDSTVRLSAIGGCAISDEEINVVERMSSHMPSTLQTRNCPTVNSSENDKGSQLSDVTAKICNSFKCSICKICFKTKEFLCDHLQEHIKRVLSFQKVQEWTQKSSNYFSVGVQEDEDYHESDASSFVSGLESEVTSVSAATNTTADSSNFSSLETCASGPKNLRHEKKKHGHRAKGEVHICFFCRQAFSFRKDLKAHMKDQHKERVLKCPICQKEFSWQKRGKFYERHLNSHYGIKVFKHKCEICDKTFLEGSKLKAHMAVHSKEPLYKCPECGKGYGNKSSLVRHQRKHTGVRPYKCDVCEESFIEKRELIRHSASHTGVAPFLCSECGQGFTLKTSLMTHMKKKHSQPAVSAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0T7</accession>
    <name>A0ABM0K0T7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 74A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106094.2">
        <property type="nucleotide sequence ID" value="XM_005106037.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854975"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106094.2"/>
        </source>
    </evidence>
    <sequence length="671" mass="75341" checksum="66BD31B221CBF50C" modified="2025-10-08" version="1">MASFADPLETATEVMRSMPGATPQKLESRFKIRLPENPGAWAKVSTYQRQHDIHKWNNRTKVRIRAKKKQTKWSQSDQTSEPSSPPSEHASQHIAAMHPSEGVLGKTHEEEVGERVQMDGQEARETSPISVASKDTNADVSSLVSESISTPASSVLSELMEEEEPDPMLKTYSVFQLRYKENVEFMEVAPLRSVHRQLDTFHMDLKRARMSRGEFKAIATTLCSNPVVSRLDLTECMLDDVKVVYLCDLLAEDTCLTDLILTDNQMGGRSVRRLIDSLMFHDNMVYLDISGNGLRDDTAEKIAEYLKESAVLTYLLMKRNQFGRKAGALFGEVMRENNRLVYLDVSWNNLRKKGATDFLLGIASNSNLEHLDVSWNGLREEGSTALKHILAENTTLTRLNICGTGMNSKCIANILDGLSLNTVLQKLTIYHNPLLLEDFTALLQGVYNMPDTGLHKIDLGEQTIDEGAVPVVDKLFWEKSIDVSYGSTIGYSDSRHQGGNLCTRLKDDALALVTKLKPEKRLALVKYFKKLDKKAESERGRGSEILNPFLLKVQTNTVTYRDLAQRIKMEGDSPHDIINHALAQIGRVSKGHMQVARHSADIQSLRNLELKAQMEEMIDTKSDLSLLKVVKFGDPDIIDRGDDFSDTKFQQDKEKESNTATPPDPNTDTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1D7</accession>
    <name>A0ABM0K1D7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106466.1">
        <property type="nucleotide sequence ID" value="XM_005106409.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861461"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="219"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005106466.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49500" checksum="4794970628CBB9E2" modified="2025-10-08" version="1">MGQRQSGGSGGGGNEKGDDKEKKRKYEPPVPTRVGKRKKRTKGPDAATKLPQVTPYTRCRLKMLKLDRIKDYLLMEEEFIKNQERLKPQEEKHEEERSKVDELRGSPMSVGNLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNHKVHAVVGVLGDDTDPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYESNSGGEREIQRTMLELLNQLDGFDSRGDVKVVMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFTIHTSRMTLAHDVSIEDYVMSKDDLSGADIKAICTEAGLLALRERRMKVMNEDFKKAKENVLYRKNEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2H7</accession>
    <name>A0ABM0K2H7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101856459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101856459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107220.1">
        <property type="nucleotide sequence ID" value="XM_005107163.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856459"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19376">
        <property type="entry name" value="TGF_beta_GDF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF78">
        <property type="entry name" value="GROWTH_DIFFERENTIATION FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045270916" evidence="8">
        <location>
            <begin position="36"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="422"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005107220.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60114" checksum="307854C2BDAC9CEC" modified="2025-10-08" version="1">MQSRLGRTSTKYFHLLSALLPCLLFLAPVCHVTHAKAIPAYPQLRTPVTNRSQNEVIKSNLSPGSESDYIVWSPDYESLVEAFKAKILSKLGFGNSYLKNSGISKMHKMSTGAKREKIKEFMRRLRQKQGESVGTESEVKPADEQEKKTMKTTLYYSKDPSTQISLSSSSEIAPLRILTFQTNLKHPAKPFHELFITSATLHIRLRQRKWRLQQHGQTSLTSQLRVNIYWLNNSESGIRAVEGDPGTLLKSFIFQDTNEQNVSLDVTSLLSLSIPDFEGNHRTTNIGLTIQEVNTAPHGSSETVDMFAEHSSGNHQQTPRAASSSDNESKFSNSEKDTMNSDKACVFQHLIPGHETPSPGPVSQEIFWTQMSKTLIPGRSDQQQQQPQRKQQYDLGQQSHRIDVDASLEVTHGFRDLRQPSRERRSAPSDECSDKLCCRHTIYISFTDIGWDDWVVSPEGFHAFFCQGDCPAKYKPATTFSQIKGDLHANNPGFIPAPVCAATGYNPLALLYKNPDDELESSEQEDMIVTGCRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2L3</accession>
    <name>A0ABM0K2L3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101856373</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107304.1">
        <property type="nucleotide sequence ID" value="XM_005107247.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856373"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107304.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11986" checksum="8C1D1E98719D3C72" modified="2025-10-08" version="1">MGWGFKDMFREDLKFTMGFGPRAFGKYPEIIPLFVIVCIPISLGIATGYRLMANGTDVRLVKSRGPPHEDVGPSRCRKWINYNPEKYAPIPELEEVKKDVRHDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3C6</accession>
    <name>A0ABM0K3C6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable LRR receptor-like serine/threonine-protein kinase RPK1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101854282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107808.1">
        <property type="nucleotide sequence ID" value="XM_005107751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854282"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005107808.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25603" checksum="C7EEFF1A9F641900" modified="2025-10-08" version="1">MEISEEQKHVLGTFNLDKGPCLGRGGSAQVVLAFDRKDPSSKVAVKIISFESGKQAMVDQFHDEVSALRCLSHDRVMSLVTYASTPRQGFIVLKHYPHGTVDKSFPVESSVALGYVADVARALDYIHRLRIYHQDVKPANIFLDDDGRAVLGDFGLARRLKDGEKKVTSWVSTCGFYGPETRTGRCMCPFKATSVELQLGPPAWLWKEQLKDETANIFNAASLRCDGLKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3H1</accession>
    <name>A0ABM0K3H1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UPF0547 protein C16orf87 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101854981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0547 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107891.1">
        <property type="nucleotide sequence ID" value="XM_005107834.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854981"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040246">
        <property type="entry name" value="C16orf87-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018886">
        <property type="entry name" value="UPF0547"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31101">
        <property type="entry name" value="UPF0547 PROTEIN C16ORF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10571">
        <property type="entry name" value="UPF0547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0547" evidence="4">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107891.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22359" checksum="342514CF8F68BA34" modified="2025-10-08" version="1">MVKRMKRVERSESRTVVKKCPECDQQCPVALRACNCGYSFTKTRPTRTKVKQQQLQQQQNAAAKSAKASTSTAAADSESNLDKVGRRFRTKRMRPDYFNSLELEYASRSFRARKPKQEEKELKRKKKRGRPKGSTGIPRKPKEEKKKEEEEAKVLPELDDLYANFSQEKLQQFSFILDELNFKMSSQIFKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K495</accession>
    <name>A0ABM0K495_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101851149</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108385.1">
        <property type="nucleotide sequence ID" value="XM_005108328.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851149"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="65"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005108385.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43507" checksum="DDEA746468739269" modified="2025-10-08" version="1">MSSTEKDGMFVVTPFVNATHDQTFRGSFGPATSPPVRYFVITDLLLIIKIIRAVSYAITTFGILSNICNIIVFVGLGVLETATSLTLFALSISDLSFLLILLMYWTLLFLVNLGVTQTVEAVSVEDLAYQFLFYFRMVYTLSELFTVYLAVQKCCCVALPFHFKLIFTPAKALATLFTMVIVVFACYAPLFFTTGLQEIVDMTQNTTRYIIWFSEDREIITNIFHNIVNLLVPTAGQVIVAVCLVVLTRKLRKTTKFRQASEKFESKDDGSKVGESKVDESKVKGSKVKDSSKLSGKELRAVQSVVVLVVMFIVCNLPTVLTQYVSYIEPEFNDFRWYGTIYALVGQLRMCLMVCCSSFNVFVYFTFNSSYRQQAIRRRRPTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K591</accession>
    <name>A0ABM0K591_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-conjugating enzyme E2 J2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109064.1">
        <property type="nucleotide sequence ID" value="XM_005109007.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852652"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109064.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27254" checksum="FB89F21D5AC15F74" modified="2025-10-08" version="1">MASKKVNSTATARLKQDFMRIMKDPVPYIQAAPVPSNILEWHYIVEGPENSPYEGGIYHGKLVFPREFPFKPPSIYMLTPNGRFMCNSRLCLSISDFHPDTWNPAWSVSTILTGLLSFMLERSPTLGSIETSLYTKRQLAAQSGAFNLNNKTFCELFPDVAEKIRRQLQKQAEELKKSTESMNTSSNSEINGDNNAAAQNDGNLNIGGPRRYLRGTMTNVLVIVGFAAFAFVVKHVLTNVVETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5K2</accession>
    <name>A0ABM0K5K2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diisopropyl-fluorophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109246.2">
        <property type="nucleotide sequence ID" value="XM_005109189.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854446"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="8"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109246.2"/>
        </source>
    </evidence>
    <sequence length="221" mass="24372" checksum="15E35EBC9B6DE9DC" modified="2025-10-08" version="1">MRLGILTVKPNGEFTQVARVDEGGRTMQGCNDCSLDYTGNLWVTAPAGDIAPNEYLRSFEEGFGSIYCLTTQGKVVHLDTGLRFPNGIAVVHDVNGLPVKLIVAETPTRILWAYDIQGPGSVANKTKWAKLPDCEQEGGPDGMDFDDVGNLLVAHWGAGHIEVFGPDGGEPIKRIKCPFDKPSNVHFEPNSNIVYVTEHTNHALWKFQWENKGMPQYCDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6K6</accession>
    <name>A0ABM0K6K6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101858365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109948.2">
        <property type="nucleotide sequence ID" value="XM_005109891.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858365"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="198"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005109948.2"/>
        </source>
    </evidence>
    <sequence length="281" mass="31607" checksum="CB67CBA64ABAF425" modified="2025-10-08" version="1">MTSGKSWAEQVDLVDEGLPPPSEEFDEKKGVKTVTEYKHNDDGKLVKVVRTFKIETMRLSKSIARRKMWKKFGAAAPDPPGPNPSNTIVSEEVFMQFVQNKEQPAVEEEDPLAKLKNQKIVQCRICKGDHWTTKCPYKDTLQPLQEKLEEGTKKPEIAPPSTTPAPKTTGKYIPPVMREGANKGRGESMSTQRKDEAATIRVTNLSEDTRESDLQELFRPFGPISRIYLAKDKTTGQSKGFAFINFHRREDAARAISGVSGFGYDHLILNVEWAKPSTQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7N1</accession>
    <name>A0ABM0K7N1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 619</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110708.1">
        <property type="nucleotide sequence ID" value="XM_005110651.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862381"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="620"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="650"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110708.1"/>
        </source>
    </evidence>
    <sequence length="891" mass="98973" checksum="8181936EC5A5ED97" modified="2025-10-08" version="1">MSCEMSSSPRAMRDCMDQFSCGLCQEVFHNFTMFMEHKLQHKELLAKETKLECMICIESFVSLACLRKHLYEQHCIQISAHDINDVASVSLAVVPNDPLTVCETVEDITSQVSEYVSEECSARCCPKAILKFNDNKVNKINPLQSQCSPLISPTVRNAGSNESPNLFVDVVTQEDSQSCLSASCMSGAVPHTLAKVALEDCSEVHILTVNSEHNNLKNDTDFKEVKACLCIEQNESCPTIKCAGTESSHCCQSSVCQGELEGKDFGLNGLTSKENNSFCSSFPCSNHNKVDKEAVSNIDLVKFPSHQYVASDCPVQIEYSSAVCSADVENGSKLGKGSNLEVCHHQIEFNSKNGIEVPESKSKLTNSHVQVAANTKDTQRTLGNVKTFNSSKDDNVEEAKMVDFHFLLGTTNIKGNSMSYERTEFRCMHCAFSTAWRPSLIKHMKYAHKDTLVIHEILEIKNCDSQQGDSQTNKNFQVMKMSEYLAGTMKTKVSKRRVRNVERQDVPGKYHCPICHKVFNRLRYIRRHQSSHHTERPHLCDACGKSFKTKATLVAHRRSHKTKSYHCPQCSFVSNNSAAIHHHRQLHPNGSVVCDICGTAYIDKSTLKKHRRVHDSSRPFPCTHPGCTWRFKTDVMRKAHVRAHTTEGKFRCPHCGYHFRQKHHLQRHIAKIHASLSLPASQTITVPLTHSLSARNATLPIPGLSTQDPTPSVCDAQALPVSAELLAPSLSSQEAEVKPATNDLEPPTLNGQSDVFSSPPSHLLCAVTDSTFTPGLMETDQTMIEVLVGDKHENLSNLEQEEEQVSSLDIPLGNPNNLEYITDSGEVVQLLRPGQTYMGRDQHGNLVQYKIADVQDPDEVSSHPIYFIGVDGTVVGTANSQELALLVPSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7Q8</accession>
    <name>A0ABM0K7Q8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Steroid 17-alpha-hydroxylase/17,20 lyase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101855451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110761.1">
        <property type="nucleotide sequence ID" value="XM_005110704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855451"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005110761.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="57402" checksum="2B9D2564D042D213" modified="2025-10-08" version="1">MISELLFTVVVIAIIVLSFRYTRPRKDSIPGPPFLHGLRTVFAALRDNNLHQIGEIWAKQYGDLVEVNAGMGKIVFVNDSDLVRRLLCDPENRDITNDRPPTFVGRHLCYNYKNIITANFSPELVKRRKVFHTALKFYGDGVHTFETLIQETSLDLRSQLKNYEGNVPLKNELTDFILRVVGLLLKGTHLMDTDLDIIANLVDTANKCFQFENETLMKFFPFARFIPGLKIKQLVNDFYFYRKELIDSFFLKAKEAYLQGEKSGIISELLDQQKKLEEEGQSGVLSDEVIITLILDIMAAAYLSTACTISGLFLYLIKDQNAQDRIHGEIQKVIGDITPVFEHRRHMPYTDAAILEILRISTISPFLLPHFANADLTIDGYTISKGSTLLLNSWYFHHRDDHWDQPWNFRPERFLDGSGQLVDPEHPQRRKLMVFGTGRRLCPGENFARSRLFLILVTLLQHFRFLPPSGEELPSSHPKDWTLGTVLSPGNYQCRVELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7T8</accession>
    <name>A0ABM0K7T8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101852058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110827.1">
        <property type="nucleotide sequence ID" value="XM_005110770.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852058"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="5">
        <location>
            <begin position="88"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005110827.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30180" checksum="B861A9F766B83EE1" modified="2025-10-08" version="1">MMASRLWRLVRPVACNLSRTSALNNCAAPALSHGLRFQTTEAGSSKPTVASPSPLVKQQLTDFGAYVAECLPKYVQKVEVSHHGDLEVMIHPDGAIPVLSFLKDHTNAQFVNIVDIAGVDKPTLENRFEIVYMLMSLQFNARIRVKTYTDELTPIDSVCSVFQGANWYEREIWDMYGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVEVRYDDEVKRVVVEPIELSQEFRKFEANTPWETFPNFRQVEGGETEAAAKPEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAN3</accession>
    <name>A0ABM0KAN3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846710</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112987.1">
        <property type="nucleotide sequence ID" value="XM_005112930.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846710"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005112987.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14059" checksum="C4A068D28659776E" modified="2025-10-08" version="1">MDEDSLTAQEEMKALIDKMGALSKQVKEKSDEEKYLFKTEVKKLQELLSCSQNREDTMTVEQTERLKASMYRMQAEFEQRTRQEETLKKQVRQAEETLADLRRQLEEKMQQPGAQPRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAY3</accession>
    <name>A0ABM0KAY3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864505</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113217.2">
        <property type="nucleotide sequence ID" value="XM_005113160.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864505"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113217.2"/>
        </source>
    </evidence>
    <sequence length="217" mass="25257" checksum="E0734FEE4A116417" modified="2025-10-08" version="1">MISYSSFLLPGGVPFSGHNLVFVPPLITHSMSCRYQAEVLRRKEDIMMASLQSLHSKMDQQEKRLEQMETVLSEKTSESVINIPPVKFEHDFLVIQSYVSKHHATTWSEVWKVGQGRPQFEAGVRFYNSTFWRKMAVCLKCSRNKGISGTEVLVKVKVTAVSSRGREWNVEWKKDVPKLGYFSHLMWVTGYLSLSEMEENGFFENETLRLRFEFWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB83</accession>
    <name>A0ABM0KB83_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Atrial natriuretic peptide receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113418.3">
        <property type="nucleotide sequence ID" value="XM_005113361.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857168"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="112"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005113418.3"/>
        </source>
    </evidence>
    <sequence length="295" mass="33740" checksum="3C348FF6898E035F" modified="2025-10-08" version="1">MFSAFTRAWELQHGSEHKLWNPVWPLFTFYTFSNIIQLVRKENPPSQMAMLRRLRCTQVSLLIFGLLTSHLYNAIASNDSKYKLPRAPSDVIKIGVILPSTGSTPWILPYTLPAIHIAVDYLQHRTEIFGNRRVKLNVADSECSYITGPLAAVDMYVNQSVNVFLGPACEYVVAPVARFSPHWGIPILTAGALVSAFGNKQEYGLLTRVQGTYSKYSEALMHVFNQFRWSNVALLYHNVNAPNSEKKSCFFCIEAMFRALRAKINRKPFNRDFDEHRISEQRREDIVVEASRHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBD3</accession>
    <name>A0ABM0KBD3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862326</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113511.2">
        <property type="nucleotide sequence ID" value="XM_005113454.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862326"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045432152" evidence="1">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113511.2"/>
        </source>
    </evidence>
    <sequence length="124" mass="13423" checksum="FDA35610D40B27EB" modified="2025-10-08" version="1">MFSVSTKYVSLAIAAIFSVVGIALASPVSQPTIDNPCRITSSAPPEYLSLQEEIALTVNVFETLRSSCEAGMTTITTENLLSSGEINVLMDDPMYNLPGLPLATATRNISEENMARILLEDYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBI5</accession>
    <name>A0ABM0KBI5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell cycle serine/threonine-protein kinase CDC5/MSD2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113591.3">
        <property type="nucleotide sequence ID" value="XM_005113534.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864509"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005113591.3"/>
        </source>
    </evidence>
    <sequence length="321" mass="36522" checksum="1D429499B9FF78ED" modified="2025-10-08" version="1">MSTKMNLRPGECTISSFSPEDVLGMKGDGTIALGVYCYVIRVADVNDPSKKMALKTLKFLEDENGYRYQRFLFCNEVRFLQNVQHPNIIQVEKALVCPGEFVIATEYHPTNLFNDLRRHTQAEVSKYFSQVVDALLYLHDRHIVHGDVNLQNVLIDTQGNAKLCDFGMAQLVPNKSSKRWGGYTTMYYNGPEYIRGRPAEDVFKLESFSLGVCLCALSLRVYPDKDLNYLELLRAGESVPDIHRVCAERLLCPSTVERASISEIHQRLNDHRQSESRAQSDVIHESPAPVSVPTPRKCSHVKEEYRNLHSRGKALKQKTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUR6</accession>
    <name>A0ABM0ZUR6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Blastula protease 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106011074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934867.1">
        <property type="nucleotide sequence ID" value="XM_013079413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011074"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046845024" evidence="3">
        <location>
            <begin position="21"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="155"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012934867.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32811" checksum="F8727C0730462C9D" modified="2025-10-08" version="1">MGLFTLFTVGAFSFLVFVSASPYKESLKAAIKNGTLVEKEGEVQEYIMSWEEAVIEEAEERKAAMARGSLYSFVPDRHSRPRENMKALKGRLTEAGLSFKEMADLFMTTGDTFDDLTSEENNQSGERPQDRSWVSGQGQGQKKQNGNGHRSRTKRAITPSEYYRWDYGIVPYMFTESTGENNQKEIRRSQMTFERLTCLRFVPWVNESGVTTNDRLGLGHQGHLRFVVGGGCWSFLGNLRKSSGQQISCCSGSTCIHEIGHAVGMHHEQQSPSADRNWMIRINPENIQDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV10</accession>
    <name>A0ABM0ZV10_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854395</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935019.1">
        <property type="nucleotide sequence ID" value="XM_013079565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854395"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935019.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="17607" checksum="57F7E3E33532AA74" modified="2025-10-08" version="1">MDRNGTEALPDLLCSRVINPSFQGHTGTGGERVYQNAKAATTGESTGTGPGKKPKTAPKPTRKATPQAQTLEPASPTSPSSLASLASLPSDTSGDVYAKVQKLPKTQEMPHPSADVLEDLQGEHVYNNTDGHHEYFSNSSLLGDDKVSPSAPDASLLDDQVYYNTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV42</accession>
    <name>A0ABM0ZV42_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fucose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101851792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935083.2">
        <property type="nucleotide sequence ID" value="XM_013079629.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851792"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="GDP_fucose_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15045">
        <property type="entry name" value="FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15045:SF1">
        <property type="entry name" value="FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucose_pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDP-fucose pyrophosphorylase" evidence="4">
        <location>
            <begin position="83"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012935083.2"/>
        </source>
    </evidence>
    <sequence length="608" mass="67765" checksum="87BBD3A6A9E0E95A" modified="2025-10-08" version="1">MFFPLPGRPKDSSGKPFWDILVITTSDASQKEAFQIQIDEKIKRQELPLDLPIHIISDPPGIRIGNGGSTLVALEKLESEYGSELFQKKILLIHAGGWSQRMPSSTILGKAFSLLPHGNPPYQMLDLKLALYWPFVEKVQPGVFIACADDFVVYSLGSDVDWECPANGFIALAHPSPISIGRTHGVYVLSDVDKIDTEKKVVVSNCLEVLQKPSDERMKTRGAVLKGDSHTFADGICVQGETVYTDSCFYFGMDVVKKLLNFKKSAGDLSCEIDAYGDFLQAVGKNATSSYIHNVGNVSQKTSNLLEMRQGVFDCLNGSDIHVLVLNASAFIHIGTTKELLYHFCQDADFQAQLAFEKDVFNVWLREENSDNNIKRSDRNPEKISADACVMHSAFYYETRIDGQCVIDFCDFDVPVHISSKCILSNCQLSLLNEKNRDAEISIPPSMFFNTVPIVGARFVTVYFSIGDNLKKSVCYEDIESLPFMDSDVGHFLEDQGYTIKEILPSDEKNNSNSVSGACTSPDTKHVDGMHKDNKKTYSLWNLRLYPAAPSMTSSLEEALQGLSSQPRRKVSKASKSMHSMADLLKIKDVKAMLKFRSDLFEKIRANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVV5</accession>
    <name>A0ABM0ZVV5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_012935612.1">
        <property type="nucleotide sequence ID" value="XM_013080158.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845308"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012935612.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35979" checksum="6CD34658C68373FF" modified="2025-10-08" version="1">MSLTGRTVFVAFDRLRWCRIPKVGTTYIQYALKEQLNTLEKVHGGSIKRYRARKRKSFVFVREPYSRLISGYIDKVLTTPSWWSTVGYDIMKGARVLNGSDKWTKKCAAYATFADFINYFIESETSGLHRNPHFIPIHDQCHLCQRNYTFLGHLETFREDLAHILKSVNVSVQIVPLEEKTILRKTAEVLTDGLKYVRMCTDKFTVMKSLWLSFQVRGYISEDMKLPVSRNQSEKISGEQFGNLASNAHLFSKDNFNHTQQRKNMISKMYRQIPLHQRLLVKKILEKDFLMSQYDPLPAEVFPEFSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVZ5</accession>
    <name>A0ABM0ZVZ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T-box transcription factor TBX20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935666.1">
        <property type="nucleotide sequence ID" value="XM_013080212.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860458"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF207">
        <property type="entry name" value="OVER COMPENSATING MALES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="139"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012935666.1"/>
        </source>
    </evidence>
    <sequence length="698" mass="77419" checksum="0508DD0496DFB18D" modified="2025-10-08" version="1">MTLSAKAQAFCVENLLKPSVSRNSSDSPQNLATSCKEDILCVRIPKVVEDSLRDAEEEERYNAVREKGVEAGTEENRDDRCFESKHLEQKAEDKECVSPAAPHRPAYCFCHGDISFCHHSGILSVPDENGLAKSIVVELCHADLWASFHRLGTEMIITKSGRRMFPSLKLRVSGLNPDKLYSLKLEFLQPDTRKHRYIYHSSRWIVSGSGDALPSPPVHVTPDGPISGQAICSQIVSFERLKLTNSDAGKPGQVSLASMQKFQPQVRIEEVCVEGQEEGKKTESYSILFPQTSFMAVTAYQNQQITTLKIASNPFAKGFRESGKARIPYDAFMAPYPKFLYGNVGLTYFQAPLKPPIDLRYLSEEKEIQLSTSGKRLAYSDEEDATELGKPSKLLKLDDHQRYLSHSVKQVSSPPSPGSLMPVPSSQTILSATAPPSLFLHPYSPYHLSPQPTTLLPVPPAHPYHPHHHHHHHHHLQQAHTVQMAGPFPPPAHLPLRPMSQNSREASSMRVVNPYINLHCEGTQGVRYAQNLHERRFESLTSKPVEDSLCAEVKDYRYDASPSERGSPSSHSAKSLSSPSSSDQSPTTTHPSSSKSGRESSPDSSPPFSYSPFPLKRCKTEPPEDGNDSSAPCACQDCESSTPLAWTSNSGTPPLSAKPWAARSKFAPDQKYYILPNSLENKNISWKVQCQDLRSECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW59</accession>
    <name>A0ABM0ZW59_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neuronal migration protein doublecortin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935782.1">
        <property type="nucleotide sequence ID" value="XM_013080328.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862930"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004">
        <property type="entry name" value="DOUBLECORTIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004:SF23">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="37"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="210"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935782.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31102" checksum="53E5C39E6FF0DE26" modified="2025-10-08" version="1">MSASVTEHAPRRVLNNPPMQVQRDFADDRYRDLRRPRKLKFFVNGDRYFRGKKIYVTPNRYYNFNDLLNDLTGKLPSNLNLPYGVRQIFTPVSGRRIFDIEDLSDGETYVCAGFEGFKMIKYGRAELEPWSMARPQQPANTEAEGEPATSYRYRGYANNAFHPGRYFRTNHSYQQRRWPGTFGNQRAGGAYGSTGAAPGAQSDNAPGKPKVITIVRSGPRPRHNVKILLNRRSVQSYEQLVSDISEAFGPRYRLNKVRKLVSVRGREVQGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWA2</accession>
    <name>A0ABM0ZWA2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101855241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935850.1">
        <property type="nucleotide sequence ID" value="XM_013080396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855241"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35538:SF3">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35538">
        <property type="entry name" value="LIG_CHAN-GLU_BD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935850.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51921" checksum="CC4DD13CEC3394AC" modified="2025-10-08" version="1">MDIQDPLDFLAKYCIINPDRLPFYEIIFESTVAEQTPKYTKQEKKADQNEGAGGGEKKNDGVEEEEKKKKGKSGKKKKSAKEKQKQQEINPALLPTERGMNIEKAALTIEEQHLEKLIYTLDTLHEKMLDYGQQLEVMEVERTRVLARRAKDLFPEITSPDYFPKLKKKGKKGKKDKKVEPPRKLRPDEITPEVIVGRLDDKRLSQLTSEPDMKQMEAEIDRLKDKIRDIQMRVEQIASEKLLADAFCMNHYFLRQGLNGTPTLPPTDFKRQQSELYNRLHPHPDFEMNLEEVEEALQQINNHLITEKEFFFLYNILNLPGRERINFRLFSIIAALSEKVSQLDPVIRKMINNFNYNALDIKMEKCKELFELLEAEHMPRGGAQAASLAVELTAGGLKPEHTNYVLHKFNRENRGVVDFLDFVTYVPLFVEIHKRIVSHPLSDKFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWA9</accession>
    <name>A0ABM0ZWA9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KICSTOR complex protein ITFG2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935862.1">
        <property type="nucleotide sequence ID" value="XM_013080408.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863705"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031793">
        <property type="entry name" value="KICSTOR_ITFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317">
        <property type="entry name" value="INTEGRIN ALPHA REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317:SF1">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN ITFG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15907">
        <property type="entry name" value="Itfg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935862.1"/>
        </source>
    </evidence>
    <sequence length="609" mass="67099" checksum="FA30CE66072E192F" modified="2025-10-08" version="1">MSFALEGGSVKCTKIAMGSDMNNTIMRTVSFVERIEVEYHGNIITQAMVLADVDNDMANELVVGNIEGHIAIFKGDSSKAWKKTTVSGMLTCLAVGEIHTPHKNSLVCITAEGWCYVYDITPQSPFQNLSGDDSDESRMFRPVFTQELPANARVMCLADIDSDGHVEMVIGYSDRVVRAFRWHVPHDPESGHFVPLQKWQLAGQIGSITINYDKEHRPELMVSQPGATFVSLQVRPQFRHIKSESHLDKLSGSRASSSLEHSGSFGASAAGDSLKASGKQQTQGAQSNGNKSDPLSSKTEPASSSGLSKVSAKSSESLSSANTLSSESKSRLDTSNQESVSKSKSESPKDGHNDSSSVKVSMRQRGDKVNIQPHISDCPFDSGESQLEKSQGRLSQFLDSSFDEDGYLIYHPLANSQIRNKDTSTVIIGGINRGRTSHSSTDSDPPQSQATYYALATLDGSLNLVENDTILWSLHVDHYLFTLSKLDVTGNGKEEVVCCSWSGQTYIVNHSKETVRYDFPDSVAAFCAGYYSVRDHVNVPCFVYATFNNRICIYPNISLPRVESTNLMKVMGRKKETKELLHKLNVNADDMESVQKLYHWCLYGQHRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWB9</accession>
    <name>A0ABM0ZWB9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101861110</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935875.1">
        <property type="nucleotide sequence ID" value="XM_013080421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861110"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935875.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45196" checksum="F86AC5B83E150615" modified="2025-10-08" version="1">MTSLAQLSPPCPRTGTLFRFLVAVVALVGFVSYRYLDISLPVRELGGWWGAGESRGQEDHVQENQPDLSTYGYSTSIGSVDLVKTAVMTSSKLVWPSLLGTNITVEEIQSKIKHWVARSVSKNPACADVHKNMTSYWRSVSPGLKTLDADFRRMNLASDCGAFNDQRLMAFAPSDLLSPWERDYLSQPVFDDMKDTAWATLSEVDAVTEGPFFVGDTVQFRITVKDGRGQRRPLGGDSVRLWLETADLKAAIAADVTDNKDGSYLATAPLPWKGSVRVKATVAHTRELFRTSLYIQRIYKTTHWITGSFFSRDASEATPCSPFPVLPGFSEQEVCNVTKQNGGFPWFCGKPRKSAHLQCSHFSGVTKLTVPASYPLTEAEEEILYLTESWGKTFPHPEQSRTGRFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYI6</accession>
    <name>A0ABM0ZYI6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ena/VASP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101853548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ena/VASP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937173.2">
        <property type="nucleotide sequence ID" value="XM_013081719.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853548"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01207">
        <property type="entry name" value="EVH1_Ena_VASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038023">
        <property type="entry name" value="VASP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014885">
        <property type="entry name" value="VASP_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF22">
        <property type="entry name" value="PROTEIN ENABLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08776">
        <property type="entry name" value="VASP_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118370">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="WH1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012937173.2"/>
        </source>
    </evidence>
    <sequence length="351" mass="38738" checksum="495DD57EAD299555" modified="2025-10-08" version="1">MYGGYGPPDQEELDDSFEDNGPNAYGEVPIISARASVMIYDDANKKWVPSGSTQGLSKVQIYQHTSNNTFRVVGRKLQDHEVVINCAILKGLKYNQATPTFHQWRDSRQVYGLNFASREDAENFSQAMLTALETLNSLYRQPPPMAPPPQPPQPQPQGNIYAQAHNAVNGPSEQEDRMQRDEPPTHKRQMSGGGGMRETEEMLIQLLLGPVPRPMYVDPGRNLRAMEEPTGLRNPSLTGQEAVAPVNGGGALGGDMEALKQEILTEMRREMNKMKSEIIDVLPVYLSRGTSAERSPLTCYSCHDDPDDPEDCLLQEETCDPGEELNLGLLCATAKGLTVTATPQPLVFVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0I5</accession>
    <name>A0ABM1A0I5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101845851</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="10">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.1.3.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_012938349.1">
        <property type="nucleotide sequence ID" value="XM_013082895.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845851"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="11">
        <location>
            <begin position="15"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012938349.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28672" checksum="09ABDE0E6C97F6E7" modified="2025-10-08" version="1">MASPSRIREVRGMTDDPLKQLSDLKPKLLVDDTDAVLKRLLDAAKAKGGQGGRVDIVMDNAGFELLSDWCLAEFLLSSGLATSVHFHIKAMPWFVSDVTEKDFNWTLHQMSAMNHIAMSQLAQKWKQRLNDKTWIIEVDNYWTMPNDYAQMEELNPALYQQLSQADLVIFKGDLNYRKLVGDLKWDYTTDFQTSLRGFLPAPLCALRALKSNSVTGLKKGQAEVAEKESSQWMVTGEWAVLSFSSGKTTSQPCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0W3</accession>
    <name>A0ABM1A0W3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">RING finger protein 37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101858555</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099435.1">
        <property type="nucleotide sequence ID" value="XM_005099378.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938555.1">
        <property type="nucleotide sequence ID" value="XM_013083101.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858555"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16660">
        <property type="entry name" value="RING-Ubox_RNF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039925">
        <property type="entry name" value="RNF37_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039847">
        <property type="entry name" value="Ubox5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045696">
        <property type="entry name" value="Ubox5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13492">
        <property type="entry name" value="RING FINGER PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13492:SF2">
        <property type="entry name" value="RING FINGER PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19318">
        <property type="entry name" value="DUF5918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U-box" evidence="7">
        <location>
            <begin position="259"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="489"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005099435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012938555.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="59235" checksum="1DB4654932E5DD0C" modified="2025-10-08" version="1">MIDFSLGVLGTTVSSDKVSTDGHEPSNLISTDLRLKRTGFMTEHFIKPPVNITFIFPCHISIHQVTAYPSIGQQQSLQFEIFAAAKPISKAMREGKKLDKVLNNPSSVRSETPPFFYNLAKMSVSNSAQMCFYNPNSNANVQHQSSNIPLPASFENKAVLRHSKKELLTACSHLCVRITQTRSGSTACLSNIAIWGVPSHSLSNVIRAQIQNKYNSIFSSSTKCGASASGNNGQTSDVKQLKSNPHSVDAQATNSQELDIPEDFVDPITCEVMAVPMLLPSGKNVDMGTLDRFFKSEASFGRKPRDPFTGVEFTDSCRPLPNGALKIRIDHYLLKHSQDAAVASVARTVGTAKSYTKKATGGKSCVSVSSLAPPAHKPRVGEDQPVMEMKRKSYVSSATPPSVIPKKKAKTECLPFPKGDHHTEHVSTSSNERSRKVFVSSPSSDLLESHESRLKDSLDSALQAMLGQISSSPSSSRTNSDMDAESNSCSLCQKPVTSSCVAYGTPCSHIVCRNCLTQALSKTIKCPSCGNTYLKADVIRVHNASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1A7</accession>
    <name>A0ABM1A1A7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938807.1">
        <property type="nucleotide sequence ID" value="XM_013083353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011962"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF84">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012938807.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36406" checksum="959D522097D078F6" modified="2025-10-08" version="1">MTQNKISIMGITDIRKKGTGTKEIHSNVVLIWSGERKDQRAEHSVGFIIHPDKAKEIINTDFISERLIKISIREGKKTTNYIQVYAPCNDSYSDEEKDSFFEQLSDLISSIPDEEDLYVMGDFNGRVEERRTPWTKHLGPHSDHRAQCNYNGNHVLELCSEHDLFKTNTFFQHSLSDLHLVQMEQLQGLITVRLHISEMWNADHNHRLKSHPQYRPDTDQRPIITTLTTKKERKSKNLKRQQERINMHKLGDDQVQAQIRCTLNEKLGSTILTVEEAWDTFKTTLQDTMQEVCGTKKTREKHIKAIAWGNEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2B8</accession>
    <name>A0ABM1A2B8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cartilage matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939406.1">
        <property type="nucleotide sequence ID" value="XM_013083952.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855111"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046845025" evidence="1">
        <location>
            <begin position="19"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="39"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="232"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939406.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="46927" checksum="31F9C4BE2E31083F" modified="2025-10-08" version="1">MKLLLPLAAVCLAHFVLAAPTTNDECPPKKDPCVSEIMDLSFVVDSSQTVTAEGFKQALNFLSSFLGKFDISPNKVRSSVITYGRGVYTGEAIGFSDYSDKQSLLSAINDIQYQAGGRTDTGAGLEYMLDNQMSQARENVKRVVVVLTDGDSQDGSFTKKAAQRVRDNGIEVFSIGVGPDIAMQELLNIASSPENVIDAKSYDSLNHILNQLRVKICEESDPEPSCRHTPTDLMFVIDSSVSVGEDDFELGLKFITNFLQNFEVNPSTIRVAAIMFGKRVYDEHVINFDDDDNVENISKAISALPWMHGTRTETGKGIDYMVEHFLPYTRPRVPKVAIVITDGESQNNNKTAAAAQQARANGIQMVAVGIGRARTEGGKLNLKELNDIAGSKSSVLLADNYADLTRIKGKLVQQTCKQIDFGYQALMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2H8</accession>
    <name>A0ABM1A2H8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939516.1">
        <property type="nucleotide sequence ID" value="XM_013084062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012133"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939516.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27350" checksum="BDFC40E490233915" modified="2025-10-08" version="1">MTGTSLLDVYADNYRRHNLETRQLDRCEGGVEWAWLELEECLQGPFAIGGYVVAVASLPVWVLGGVVHYRRVSVESRDWLWSQLFLHALVSLASLVAAIFSMQLTLVICQDLVSLLTVSLTAVVFLVQASLGKRDRPPYRRVYDMQKNPCLEGSPQPSLCWTSAPKLCCLPIAMFVTSSMIITESARDLHFRDSSSLTAERQSSQKGQITMVVLGYTLACLASFGHWALAVWYLKFYQYLEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2U9</accession>
    <name>A0ABM1A2U9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type mannose receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939711.2">
        <property type="nucleotide sequence ID" value="XM_013084257.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012171"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939711.2"/>
        </source>
    </evidence>
    <sequence length="93" mass="10646" checksum="16CEB70E812CDBB5" modified="2025-10-08" version="1">MKKSMRFQWSSSRQVNFTNWGLHQPDSNPGLEERSVVMNINGGWSTAFSESNYMYVCKTEKIPASKPVQEATDPVCGKVRAYYMSLAVTWRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3H7</accession>
    <name>A0ABM1A3H7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC106012254</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106012254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940081.1">
        <property type="nucleotide sequence ID" value="XM_013084627.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012254"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF15">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="8">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012940081.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32367" checksum="EDB51C0E6325D280" modified="2025-10-08" version="1">MLRNIWKLKTVLSVCAHCVIVSVLLLWHCTTPANGLDNVALGKPAEKTEYPYTYNGLYLARFAIDGNNDTNVDNCSFSGYIMNRHLWWMVDLLQTFLVHSVQITSASYNFGLSPDEIILKNSSVYVAEGNPQNDPEFPNENSLGKLCVRVETEIGRRKTVLQPCVSPVSGRFVTVYRSKWDLILCEVEVFAQAVNASSSTVQFSMDISKGRKSLQAPPLFSRQGVRSLLECATVCVGKKGERGEVCNSLHYQRSTRDCECLQLSDLHSYKEKQEPNSRWTLATLNNGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7J9</accession>
    <name>A0ABM1A7J9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">F-box/LRR-repeat protein 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101858571</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106281.1">
        <property type="nucleotide sequence ID" value="XM_005106224.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012942369.1">
        <property type="nucleotide sequence ID" value="XM_013086915.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858571"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942369.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="49645" checksum="B5E6DA6149140887" modified="2025-10-08" version="1">MWDSLPEYMLAEIFAYLDVFDRSAVCNVCRSWKNAAKHPDVWNWITLTREHFESSKYGADVACIIFNNMKYCKALTLDLSVSEGLHVTEVASRFCKNLKHLKMMSMSPLRRFGTKFELFPRTFFTLFEKNFNLESIDLDNVALCYSTNHPLPIGPRHAKTLRKLRLINSMVTFSPSSLMYLVNLTELTMSPNFLHYSLIKHLSKHSLKRLNLVDRSNVLGHSETLSEFKWEEIASQKDFRVGYFIMKKMSFLAPSRKFLVSPGMPLCSVVYNNNSWLPYTALLKLLGPFSSTLEELVDFSLSKDGGWTDSGDELLMSLVKSFPHLRTLSLRVPISTGTLLLMVTLRENLINLPVREDMVSFNCTLDLDEYTQLSQQQKTRIQENCVCKESFEAAMTFLTCQPWHLMEWQEYCDWMRDRYGPFLGTYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7Q0</accession>
    <name>A0ABM1A7Q0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 27-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942453.1">
        <property type="nucleotide sequence ID" value="XM_013086999.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012845"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942453.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24702" checksum="EC01353E1D05E4A0" modified="2025-10-08" version="1">MAASMMQCEFTLLSSFPVPETTDCPTIVKQFLQGDYEDILESSECAKKLLSHQNAENASISDLCKFIKTNVETLMLDGAENTDCRDLSVLTVAASCLQLFVQNNWLGPPTTKSPIEFLQNKFHSKLKELNVEAQNELSADGESVYSQSRHLLYLYIARIILLECHSFFTESKTWDWWLMRCLLTQQTLLSDRSPTLKATVMELMDKCNMLCYSTQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A946</accession>
    <name>A0ABM1A946_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101863844</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101863844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943188.1">
        <property type="nucleotide sequence ID" value="XM_013087734.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863844"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="819"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="43"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="8">
        <location>
            <begin position="505"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012943188.1"/>
        </source>
    </evidence>
    <sequence length="863" mass="95425" checksum="7887EB848C5F960E" modified="2025-10-08" version="1">MIKAFVFQGCLGPDPPSSSTSESSTPPSSSSPSPTGLSATRVALVFLAWTVTSFLCHQLAKSFLTETHLDIFGSRSLQGNLEPFLLALFLTLVQCCVCLLMVRNPVLDSCDSDVRVSVVIVTSHLLATLTTNYSMVYIQAASTFAIKLTEPVVMAVARRLTFHSPLTPQTLASLPLIILGALLFSGVTVNNLPGWAGILLAFTSNVALAFRNVALSRVQRGDDKSSPRISLRSAKTLTGVLLSLALTSFVVNYLETWEVLAVTSSRLLTMALTSALFHVTYSYLSTCVVLKLMDVISHSVCNIFKRLLVVWLLYSCGARSATGLNLLGLFFAGLGLALYLHGKLGYGHVTECVRRPIIISLADWVKSSVMVALILLLVLAGLKTSQCGKTLDLGRVLGQSHISLSAGYVVQKVGFEPAPFAIRKMSAVDGDEEDLKAVVLPGVSVETFKTWRLLEHPTHTDFLSHTLTDNRAVVGEAQRVLLNLLSDIIGSASHVMLMEIATYENKGDPAIATGEVMLLRKLNKTVVYYCETHTCTNGNLNYALKIDSRYAAGDLVVLMQGGGNLVGYQSNDVVRRRVLERFPHRKLVLLSQSIWIHPKNHAHLQECRKIYSNRPNLIMLLRDRQSFALARQHFNGTRLVLAPDMAFGIGLIPRQLPPTLDIVWLRRDDHESTRYELPPFPDDLAIHVGDYVHDWNSNRGHTDMETSFLIASAGLQYLQRGRVVITDRLHGHILSTLLDIPHVLIDNPPYFKLSSFHRSWTQALTNTAMVTTGHQALAEARKMLQRYSSSLPPVAPYMHAPSVDPGASYLWLFLKYNRLYIMLCALLPALGYVIWQRRRQLVVVCRACRIGRTQQQSQDKSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9V5</accession>
    <name>A0ABM1A9V5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943604.1">
        <property type="nucleotide sequence ID" value="XM_013088150.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850115"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF5">
        <property type="entry name" value="WIDERBORST, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012943604.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="53931" checksum="B07721442440DB42" modified="2025-10-08" version="1">MSAKIADRIDPFTNKAAVKSKKQKRSQGSSHYRANTAPELQALPHLKDTPQNEQQELFIKKLQQCCVVFDFMDPVADLKSKEIKRACLNELVDYITATRNVLAEPVYPEIVRMIACNIFRTLPPNDNPDFDPEEDDPTLEASWPHLQNVYEFFLRFLESPDFQPSVAKKYIDQRFVLQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEQFIGVGELLEILGSIINGFALPLKAEHRLFLMKVLIPLHKSRRLCLYHAQLAYCVVQFLEKDAALTEDVIKGLLKFWPKTSSQKEVMFLGEIEEILDVIEPTQFQRIQEDLFRQIAKCVSSPHFQVAERALYFWNNEYIMNLIEENSNVVLPIMFPALYRISKEHWNQTIVALVYNVLKTFMEMNSKLFDELTASYKSERQKEKKKEKDREELWKRLERLEFNSKKNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC38</accession>
    <name>A0ABM1AC38_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101860534</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101860534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944875.1">
        <property type="nucleotide sequence ID" value="XM_013089421.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860534"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16787">
        <property type="entry name" value="mRING-HC-C3HC5_CGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042496">
        <property type="entry name" value="CGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15379">
        <property type="entry name" value="CELL GROWTH REGULATOR WITH RING FINGER DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15379:SF2">
        <property type="entry name" value="CELL GROWTH REGULATOR WITH RING FINGER DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="486"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012944875.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="62603" checksum="21A1CBE33D69F8E8" modified="2025-10-08" version="1">MGMATPVLLWFASFSNVTSIVVVALCFIAMTVFIGFVSLNIDSSGSSHLTIGIEERNMVKVSNPFFLHLDSDKRTLQGCVFPSTDGLRAVLSSLCPCEVVILWGPRINPLHDLILKPGTEVRRACRDLSCEMYRQLEALHSTQLQYLEPGEHEICDRLPESVSSESLGDVPRDRYPVAVLTFVPQPGQGHDSGATQGQDPSQNSGDSSEQEAGAGGREEVSDVCESMEDPNCIIGLVSIIHLQDGRVHHKSHVISQYIKTAGVALFSLKPLYMSSRPADAPAEGHSGGIEGHSGGDEGHSGSDEGHSGGDEGHRGGDEGHSGGDEGHRGGDEGHSGGISRNRDGRTNTSSYDSRNRDGKMIPDTLQNGPRRGGGKIRKRIGKGVHREIALGRSPDSDPTTSGRVDICQPITSGRVDISQPTTSGDVDISQPITSGRVDICQPITSDGVDISQPITFGRVGEVGRDVSPPGVESLERPCSCDCLPECVVCQTRRVRCVLLPCRHACVCLGCFKLLDKCPLCRGGLESYFLLGDQENSNCEGDCGGDGEGEDAILQELHQQAVRASLGQVWEDFHRRLYGLLGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACN3</accession>
    <name>A0ABM1ACN3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106013578</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945154.1">
        <property type="nucleotide sequence ID" value="XM_013089700.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013578"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045665085" evidence="2">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945154.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19025" checksum="1E99AEDA755702CE" modified="2025-10-08" version="1">MYSVTGASLCALVLMVCVQAVYPIGLKSFEETLFFDLGYEKEEYAGRYYLSNPLTNSFDAQYACSKISNNGFLSEFDTDGERAFIIKQIEPYVFATERIHIGGENLNTGGGYSTGSNSSSSSSSSGNDPPTYYPPETRECNALVKRSPSRFDVVVVSCTRLVARFLCEIDDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE74</accession>
    <name>A0ABM1AE74_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Glia maturation factor beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101849984</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112631.1">
        <property type="nucleotide sequence ID" value="XM_005112574.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012945986.1">
        <property type="nucleotide sequence ID" value="XM_013090532.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849984"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005112631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012945986.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16228" checksum="5DDE2560AC646344" modified="2025-10-08" version="1">MSSNVTICETSADVLALVKKFRMRKEKNIAAIVLKIDKPTLTIVLDEEHEDITIEDLQDELPAQQPRYIILSYVQKHDDGRTSFPLMFIYVTPQGCNPEQQMMYAGSKLEAVKNLGLTKVIELRSLEDLTEETVLDKLKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEV1</accession>
    <name>A0ABM1AEV1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106013952</name>
        <name evidence="9" type="synonym">LOC101851557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946338.1">
        <property type="nucleotide sequence ID" value="XM_013090884.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012946339.1">
        <property type="nucleotide sequence ID" value="XM_013090885.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851557"/>
    <dbReference type="GeneID" id="106013952"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF551">
        <property type="entry name" value="RE08073P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012946338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012946339.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="29763" checksum="121EA846904016D0" modified="2025-10-08" version="1">MGVVSIVGKIVLVVVNILILLLSLALLVCGVIVVAGKDIYNSLLDKLEDELQASLTSAGVTVDTSNLSFSDFMLPLAYAIIALGVLMGALSLLGCIGGCYTIKIVLVVYAIVTLALFLVQLVIVILIYADKSAFDSTVKSAIKDTLKDFKGIEGTDATSLAWNALMNYEECCGVDSYTDFTGLSDWPPATINGNPVNLQTPVMCCKTKSTDYSCAETGTATTANNWLDTGCYDKLFDLIVENAFVITAIAVMLALQFILIFFTIWILCTMDNKIDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF09</accession>
    <name>A0ABM1AF09_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc carboxypeptidase A 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101861419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946419.1">
        <property type="nucleotide sequence ID" value="XM_013090965.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861419"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="8">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012946419.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26419" checksum="FB6AF76BDC5981BB" modified="2025-10-08" version="1">MLNTYNWYLVPVANPDGYEYSIHSSRMWRKNRSAHPTSYFCVGIDLNRNFDSKFRQVGVSSNCHSDIYPGITAFSEAETQNLRDLVVDRKDKVVAYLGVHAYSQFLMVSWGNVLGNSRPHNYVEIDRVGKKMQSALEGHGFRYEYGTVYQLLDYAASGASMDWVLEAKPNMYSYAYELRPDQRSNDGFNLPPRYIVSQGEEYFDSLAVMAKEMSVCRAGSGYEQCQSHAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFH1</accession>
    <name>A0ABM1AFH1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rotatin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106014126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946639.1">
        <property type="nucleotide sequence ID" value="XM_013091185.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014126"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030791">
        <property type="entry name" value="Rotatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691:SF1">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012946639.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23168" checksum="DFFB9038D1B547E0" modified="2025-10-08" version="1">MPATGDLEPTKIDSCLILSTPVLIDDDPTRSVFTEEGMKQVFDIFTADPVDPGVKKSASEQLAIMLKDPHLHALFKSHGGVEIACSVIQQSVMSAAEEADSKQKPDTVAVLPACLSMLHSLARYDYTLRHTLSRDSELYHCLVRVSLLHQSQEQIKSDVSHILTLLLFDEVAKFDIGSVPVVFDSDSGCELVSSVFYVEPVCKILKKVCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQF3</accession>
    <name>A0ABM1VQF3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 40 member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101859316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824645.1">
        <property type="nucleotide sequence ID" value="XM_035968752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859316"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17480">
        <property type="entry name" value="MFS_SLC40A1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="686"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824645.1"/>
        </source>
    </evidence>
    <sequence length="743" mass="80758" checksum="C9FD6E3546586248" modified="2025-10-08" version="1">MSGSYKFQNGQLTLSGDSLSKPKVEPSIHQDETDVDTNTMGGLNPSAEDSTQGQKGTRKEYTSNGGPGVASGSGSGRYGGLDYVKSKDSGEGGGYDGGSHLGGDEECDPLMPSDNKSAVSHGTYFLVYISHFLSAWGDRMWTFAVGLFLVIITPDSLQLTAVFGLTMGMSVLLLGPIIGDWVDNTPRLRAAQVSLVLQNALVVTCAAVIYCYLMFEDDLLEHGDWVEYVAYALIIIFSSAANLASIANTIAVERDWIVEICGRNEDKLATMTATMRAIDLTTQIVAPIATGQIMTFAGEENGAIFIGAWNLCSVIVEYVLIWKVYNTVPALRKKKGLKKVEIDQQENPKHVPELDENQRDSFTTSFQHSMTLSRHTSLKIAATTTKYEYCPYIITILFVDFFQTNTSQKLPDNTMFTFMLHLLDRSASLMKSGEVESNIDGKTSNVKKSFEASVSTKKGKTCSQSCRIFSGITIIIEGWRTYARYEVWLSGLSLAMLYMTVLGFDNVTVGYAKIQGLSESTIGIMMGGGGLFGIFGTMLYPTMHRWLGLPRTGLASLTLQSSCLVMCVVSVWLPGSPFDLFDDLPLDPVNCTNLTATIPAVDVNASTILPPILNTSIPENIACPDVENSLVSVIVLMAGIIAARLGLWMADLAITQMFMETVTEQERGVVNGVQNSLNQTMDMIKFGLVVGLPLAPQFGLLVILSFAFVFGGWVMYLVFICRLPPGLFSRGKLGAKSGGYSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQP3</accession>
    <name>A0ABM1VQP3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein ecdysoneless homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824735.1">
        <property type="nucleotide sequence ID" value="XM_035968842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477422"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824735.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13257" checksum="1FBAAA4EFACD879F" modified="2025-10-08" version="1">MRTRTLDIGRQKAIRLLRGKSAIMILLSRSPVYRFVDSADVHFLLQLYCFSDKTSDFQYRQRKLPPSKKRNKQTNKQASKHKSKKASKNNSNNNNNNNNNNSNNNNSNNNNTGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRU4</accession>
    <name>A0ABM1VRU4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">tRNA modification GTPase GTPBP3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC101861274</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096541.1">
        <property type="nucleotide sequence ID" value="XM_005096484.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825136.1">
        <property type="nucleotide sequence ID" value="XM_035969243.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825137.1">
        <property type="nucleotide sequence ID" value="XM_035969244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861274"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="5">
        <location>
            <begin position="255"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005096541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035825136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825137.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="58204" checksum="B34283B809B38F11" modified="2025-10-08" version="1">MFARLNVLRQYCLLSGRTANFFQWTKDSTQIKYFFSSSVPHSTIFALSSGAGKCGVAVIRLSGSKSSYALKQLCGKVTKPRTASLCKLMNPQTQELLDRALVLWFPGPKSFTGEDCAELHIHGGPAVVSAVLTALGSLSGLTPALPGEFSKRAFANGKLDLTEVEGLGDLIHAETEAQRKQALRQMEGDLNQLYTGWRTGLIKSLANVEAFIDFSEEENIEDDVIELVTTSVMKIQTEMEAHLRDSRKGERLRDGVHAVILGEPNVGKSSLLNFLCQRPAAIVSPLAGTTRDVVETALNIAGYPVLISDTAGLRESCDVIEKEGISRALDRAEKADLKILVLDFEVHGANLSNVDFPTFLSSYLSDMRLYQNNFREADSVHDSPSNSDQSLSFDQVPEDSWEVLVVVNKSDLARVSDLKQVSQHASGSVCFVSCKTGQGLDRFLHVLAGRIKDLCGDPLTSSSSLTQTRHRHHLSRCKQHLEDFHNLLSYDVVIAAEKLRRATRELALITGAVSTEDVLDVIFRDFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRZ7</accession>
    <name>A0ABM1VRZ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118477555 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825189.1">
        <property type="nucleotide sequence ID" value="XM_035969296.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477555"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825189.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12276" checksum="C4BB6825FF3341D9" modified="2025-10-08" version="1">MTHVFITRTPPLKRRMTRTTTPCIPRPDHRQEDLSAREEDDLTQRIPRPDHQQEDPSAGAEDDLDNDGLDTTDGPDHQQEDPSAEAEDGPDNDAMDTTAGPSTGGPLCWSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTQ6</accession>
    <name>A0ABM1VTQ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825798.1">
        <property type="nucleotide sequence ID" value="XM_035969905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011817"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="88"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825798.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23637" checksum="63C97B3C09C216BE" modified="2025-10-08" version="1">MAATPRSGPRYKLYYFDLPGRAEAIRLAFKTAGVPFADIRVTTEQWKLMKPKTPYGSLPVLEIEGRQFGETGAILRWAGRKFGLSGKGDADELVVEAVLCQASALTEEYAVAAFQTKDEAEKEKLLGKFKENALAYLDRWEALAKDTKSSNRTYTYLVGTSLTVADLYVYRLVEELGKLTDLDLSKYKKLRNLKATIEAIPAIKDYLASCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTR5</accession>
    <name>A0ABM1VTR5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger and BTB domain-containing protein 18.3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101854255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825807.1">
        <property type="nucleotide sequence ID" value="XM_035969914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854255"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825807.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="66714" checksum="89B5EBD03995CA1F" modified="2025-10-08" version="1">MLSGNASEISAKIESEPEPGLPSPKQAGIAEKCRPPCLPYMKTLTLSTEGSSPYSSEAISISTCSPNMAMAMPLLSPQVSLSHLSAMEATSPPCSNPSACDSEKRPCLKNTSEQDSEGTEQFVCFYCDVKCHSEWAIKRHLRGNHKEEDELLWRKESAPETFFVKDKPVRRRATFKRSIAISSVPTDGSIPEIRVRSGIASNYSSAEMKSELKSDLPSTKQAVTAEKCGSPYLPNMITPTLSTEGSTMRTLSAEISLSSPSSSNPSSCNSEEETCLKNTTERSSREGTELFVCYYCGVKCHSESSIKRHLRGNHKEEDELLWRKGSAPETFSVKDEPVRRQTTFTDRSPKKRGRPRLKRRSSPEKDPLPQSEKWSRQKRRLREGFPHKPPTQDVPTSRKFQRIEWDRTIFDDESEVVNLPQVAQEPEGTLTEQRQPDNDDLLQPEARDDITSEPGGLLYCCDQCPFTVRSLFHFRLHLAQHVTATCGLVSATPSVSHSRCGICGYFADGQADFLDHVTKHTKEKPFLCSYCVKDFSSREKVRIHCNSEHKGQAVVYTHRGEMYRKMFQKPRMMVLLEPAIVLSKLSKNVPIHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTV3</accession>
    <name>A0ABM1VTV3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101847876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_035825845.1">
        <property type="nucleotide sequence ID" value="XM_035969952.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847876"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035825845.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="55631" checksum="842EF6CC2A1DD1A8" modified="2025-10-08" version="1">MVQIETRERNFVSKVLSTVTVPGGTDWSSATPLMKTKGTTQDTDGSQKLISYKMTPKPPPEPLPFPLNVITLCFRGNMKYVMFPMLMATSLGLFLAFSRAVSSTHGLNNAYSQYQTSYTLSEDDPNFIPPEHVMFGHVLREPAAGAGPMSVRSVYGRTSCDCSHCNNEEVQELGTNPSQYSQLVQHVVKRFYGRPELTNQMSAFTPRKTKQWQLDSSYYLVAGRTCADDASPLVVVTVLTLHKHAAQRQAIRDTWGSLAKGKAWPNQRIYGTVRLVFLLGVSSRDDENNMASQEAETHGDLVLADFPEGYNELTRKVLTGFKWVAKFCPGAKYILKTDEDIFIDMPRLLAVLSSQEMTNTIYGSVSLSDQVVRDTSSKQQVTKEAYAPEFYPPHVRGTMYVLPVSLAKQIVDVAEYLPYVGLEDAHITGTLAKVLEARHLDIPERLYDRTAAKKPEPCDFVTGTRLLSQGVTPKLAHALWEKVANPGECGSPDGQKEGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW16</accession>
    <name>A0ABM1VW16_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zwei Ig domain protein zig-8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826608.1">
        <property type="nucleotide sequence ID" value="XM_035970715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012279"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047434701" evidence="1">
        <location>
            <begin position="28"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826608.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25532" checksum="227CE62D86D58180" modified="2025-10-08" version="1">MPERIQLNLTLQGIAFILLHLLSLVMAVAYVDYDSSDDDQPSFLPRPSNVSFNRGETAVLVCGIENLGTKTVSWRRASDPNPLTIGEDVYVGDERYSAHGVEEAKEWRLLIRDLKTEDAGVYECQVSSRTKLINHILLRVNVKLEPVIPRHNPAISVSGTKYVEKGDPIHLVCNSTGTVDPPENLDWFKDGIKLSPDGERQLKIDKFHVRTTRTLVSVLDIMHSRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWV4</accession>
    <name>A0ABM1VWV4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium-dependent multivitamin transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101855656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826896.1">
        <property type="nucleotide sequence ID" value="XM_035971003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855656"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0915">Sodium</keyword>
    <keyword evidence="6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035826896.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26422" checksum="7A8AA3C912349246" modified="2025-10-08" version="1">MGHLLNALSIMGHTHQHLTAFRKDAQRYALPYDYKGVCDVEAGNSKLLYGEDGAVVGAVVGEATSMWLAIGSYNYGIPAKRMPFPNGTCTADLVNGSMTTVAMTTALTTSATTFTTGMMPEESPISPGLQWLYSISYLWYTGIGMIIVVVVGLPVSFLTGANSTHDIPAKYQIPVFSRIFCCLPNSWLRGLACNRDFPNPEDIRADEKDEEIIIDAPEKKKVPEDFTKKFGHDNISFDPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXF2</accession>
    <name>A0ABM1VXF2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pancreatic lipase-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101852976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827095.1">
        <property type="nucleotide sequence ID" value="XM_035971202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852976"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827095.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="29897" checksum="E790AF185CAD99A1" modified="2025-10-08" version="1">MSIYLILYKSAYLYTLYTTLFVSFQGDFNVVLVGWARGAAFPDYEQAVANTRLVGAEIKVVVNEMVAEGLNLNDVHLIGHSLGAQTSGTAGKLLNGQVGRITGLDPARPSYEFLHEDVRLDAKDAKFVDIIHTNSEAEPEGQRYGYGVHQESGTVDFYVNGGRKQPGCHDIYVSSILGSLVGKRRSLADLFACSHGRSHQYFLESIKSQCTFTAYKCDSYENFETGQCNSCANNACNVMGLNTDPNKALGSLYLDTNSTSPYCSQTAGPLYGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXP3</accession>
    <name>A0ABM1VXP3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC118478197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosyl cyclase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827186.1">
        <property type="nucleotide sequence ID" value="XM_035971293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478197"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.82.10">
        <property type="entry name" value="ADP Ribosyl Cyclase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003193">
        <property type="entry name" value="ADP-ribosyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912:SF7">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02267">
        <property type="entry name" value="Rib_hydrolayse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827186.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11344" checksum="473B55FE502BB2BE" modified="2025-10-08" version="1">MLAVSMMYQHLPEDMSMFYDGVYDLVHRYSEKGSRFITLEDTLAGYMLNQLTWCGMKEHPGYNEGWCPKCRDSATDGFWGAASKQFAIPYCVKNAVNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VY41</accession>
    <name>A0ABM1VY41_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_035827334.1">
        <property type="nucleotide sequence ID" value="XM_035971441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852111"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="3">
        <location>
            <begin position="975"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="400"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="479"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
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        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="736"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="760"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827334.1"/>
        </source>
    </evidence>
    <sequence length="1163" mass="125383" checksum="7EB658AE51264ABE" modified="2025-10-08" version="1">MLEGEDGMSDETAQALEVLLGTFPETDLNVVTRALAYALSLVGEGAFSALVEHAATYIVESDSSDLCESSSASSTSGVAMVTTDDRSEAGCSTTKVSSLQTDNRAPVGISHGSSSDHPRLCVHDGRNIGPCHTDSVGGKPEVKNVNPVVRNDGPGKNIIVISPNPSPQKECVLDPVKDSGLPHAQREWLSAVPKCETEPSFNVEFSHSGSNSVLKGKMDTSSGNRNVLPPKAPTHFSKSKSETMGKSGNTVDQEFIEVHMCESRNSGGTSQPLTPSSISKQKSCPKYPAKNAPKKFADSVDRSVEMIEDNKKKTFGPGEDSGRVADKDDLCPGRRLSPSPRDHKINVEEKRKLNSQKPDTSVIDLTSDDESDEENNEESDEEREKTLSSGSNSSSLDSLGWLTQSTQTVLDSASLEMMVEKKPSLTNDAECRTAAPTDDATQSMFDASPSARHQIPTCAVGTSSLPQIKQEKPTAEESASHTSVSSSSQEAPVQTSSFLVVQSPDGGVGPSGAHIVSWSAQEGNATSSVEGTRLRTAEQAQTCVDTSSVSSSVSSSVSSSVSSSVSSCVSSGVDKALPSTSQQGEHISSLPCPPLHQSVSLSIKVENSELLGALPQINQHLQLPFPQSSSSSELLGALPAQINQHVQLPFPQSSSSSLLTGSAGKDAQSGNTVARLSQSAPVNRQRRYKVTTKQLSSMLDGLANSLQVSRPSPLDMDTCEGASSSRLPASSLQKPNAQGAVKDSEATKRSTSMHKNPTPTKKQRKVRDRLSYCDSEAHGSDGTSEDEGKVIGALVTVDSSDEETQEFARQREDVVLSCEGCESIASVQMCGQCAHGHVVCLSCLEEEVRVVMASDKLHLTCPVHGCEQIIRREALFPLLPQLVLDLLYENIRQKEMKASAAAINSLQGLVKCPSCSYSGLLDDTVVRFVCAGQNCSVDCCRYCKGPWNASKNKDHEFCVMFSFVGQESLQDINKTPANWSQMVLGGTSTQDFVKVAIPLDSPEGKVICTYFSKKAATPVKQLWRIQNKKLWEKFVLKRIHMKDEIGTLNEKYLFHGTQMENFEKIYKEGFDIRVPTKNGACFGKGIYFATSPRLSMRYANTGKAMFIARVLCGWSTVGKNTFTRPPHHKSGRMYDSCVDALEQPNLFVLYDNAQCYPEIVVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZ02</accession>
    <name>A0ABM1VZ02_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 13D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
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    <dbReference type="RefSeq" id="XP_035827645.1">
        <property type="nucleotide sequence ID" value="XM_035971752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853365"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23453">
        <property type="entry name" value="beta-trefoil_Ricin_VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14306">
        <property type="entry name" value="UBA_VP13D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="UBA-like_sf"/>
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    <dbReference type="InterPro" id="IPR041969">
        <property type="entry name" value="VP13D_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
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    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
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        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="2985"/>
        </location>
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        <location>
            <begin position="1933"/>
            <end position="1942"/>
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        <location>
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        <location>
            <begin position="2871"/>
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        <location>
            <begin position="3882"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827645.1"/>
        </source>
    </evidence>
    <sequence length="4652" mass="515724" checksum="663E7D423D8DDF80" modified="2025-10-08" version="1">[encoded data, 4652 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZ41</accession>
    <name>A0ABM1VZ41_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lectin ADEL-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">LOC106012796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827684.1">
        <property type="nucleotide sequence ID" value="XM_035971791.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="DUF3011"/>
    </dbReference>
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        <property type="entry name" value="DUF3011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035827684.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23552" checksum="53BDDD74CB7478D1" modified="2025-10-08" version="1">MESWSYEYSEKIVENTTWVLNMTVVDRQSATECTLGESFGYQKATLWVNHGCRAAFKVCYLPVRSTKCKVLRMESLNYEYAEQKVKKAALFINMTVEDQQSEASCDLDKSFGFDNQKSIVWVNYGCRAEFNVCYMKGISSTTTVNVSSWNYQHATKMLSSASCIYSMQVAKQQSTAACTFGTSFGFVGNTMWVNDGCRADFSVDYYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0V3</accession>
    <name>A0ABM1W0V3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium uptake protein 3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101854201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828296.1">
        <property type="nucleotide sequence ID" value="XM_035972403.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854201"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF13">
        <property type="entry name" value="MITOCHONDRIAL CALCIUM UPTAKE 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035828296.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="55827" checksum="5AD929DF52291A2E" modified="2025-10-08" version="1">MAAFFRRIFSRSTFQNGRIWQKFQNPASRPSRIQALVLGGAACCSSYIIFKRYYGHLSDWLMPFSLPNVQAKDEGVAGKESPSNYREMRFRQFASVEYDNNLYMTPQDFLESVTEATPRARIGRSRLSSSDVEHMLKNTPTLHRGSDKLFRKLHDRGIISYTEYLFLLCVLTMSCQTGPTKFTGKSTNEPHSGFLIAFNMFDTDGNQIVDKREFLVLESFFILPPKERKFVPRDPQKVQKLLDLEKVFSSGPKEAEEAGPNNSASAPGKSTGSQALRRRARDLNTEIPDTTLLVHFFGRNGKNVLKYKDFHRFMENLQSEVIELEFLEFSKGLNTISEVEFARILLRYTNLDRGDVEDCLNRVRERMPNEKGITFTEFKKFCQFLNNLDDFAIAMKMYTFAQQPVSQEEFQRAVMVCTGFTLSSHIVSTVFNIFDTDGDGHLSHKEFISIMKDRLHRGARSHLMHSQNTWEAFKTCVKNEMRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1C6</accession>
    <name>A0ABM1W1C6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828469.1">
        <property type="nucleotide sequence ID" value="XM_035972576.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013259"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828469.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14592" checksum="FA6EEE4579A16499" modified="2025-10-08" version="1">PTKHVPPAEKRGLPDSLDEEHLYSLLSIEPSKRYKFDLANFRTPSGCLYCSTCDLSLGEEHQFLLHLSSRKHQDKVMGWRRKNKRKTTTTSTTTFVGSSTASGGGAKSKSASSSISRALSEFDALVSSLSRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2S2</accession>
    <name>A0ABM1W2S2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LOW QUALITY PROTEIN: cytochrome P450 3A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828965.1">
        <property type="nucleotide sequence ID" value="XM_035973072.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857526"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828965.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="48166" checksum="BB345814DCA1EEFE" modified="2025-10-08" version="1">MVIRNLDMVKDIFTKYFDHFVNKTSYAIDEPFSHALPEAKDEDSKNIRTTISPTFNTVRLKRMYGHIESNTRRLLHHLKKKQERNEPVELKEVLSLFTMDVIASTGFGVHTNSLEDPNNRFFTESKRIMDSVGLLLLITTFLDFLKPVLKFLGIASMPRMSLDFFSHFVDVVIQEKKHEGSGAGSKRHDFLQLMMEAEEDKPGQENDNRTEEEATALNSRSRSKPGLSLTDLQLPQGQAIIFTLAGYETVSSAMTFTLFLLAMNPECLHKAQAEVEEVLSGKFPDYDDIQSLKYLDMCLNEVIWMFPPGFLLGFKFRREFVNFPVXAIHRDPELWPEPDTFRPERFTAENKSTRHPCAHIPFGQGPCNCIGKRLALLEMKVALAAILQTLTPVSCDQSVYPVVPEPLLMVAKGGAWVKFDVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3D8</accession>
    <name>A0ABM1W3D8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Zinc finger protein 143</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC101858535</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945456.1">
        <property type="nucleotide sequence ID" value="XM_013090002.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829180.1">
        <property type="nucleotide sequence ID" value="XM_035973287.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829181.1">
        <property type="nucleotide sequence ID" value="XM_035973288.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858535"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF24">
        <property type="entry name" value="ZINC FINGER PROTEIN 410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="567"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012945456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035829180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035829181.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="70044" checksum="6C02CD57C9ADC2F7" modified="2025-10-08" version="1">MDEETPRNIMTQALFGDSGMLSAVASLLRQHNGTKEKEVQMSTPMLVLTSVPGKDSLHANVVLGSALGKTAGMKLKPDAPTSTEPTGMLSSLEEVHALATASLVASTQRDIAQQLAQEADGLDTPRPSRSSREKKTRQLDPQAKRIQVSKAKQAVLKTAESKVTSEMKTNIVEKTQDSVQPKALTCSFEGCNRKFAWQNHLKYHELTHTNNRQHKCPVEACDKTFFTAQRLNVHLRTHTGERPFACSHPDCGKSFTTAGNLKNHQRIHTGEQPFVCDHRDCSRRFTEQSSLSKHKRTHSGDKPFHCEKCNKTFTQSGSLRKHMLRHQLDEDMRRSSEHASDRFEEEVAEKSHLSRNPNSSPGSCGEVSCSPQVLVLNNSYQGLPTSESMVFSHGLSEHIVTVSGQSMEHTLARSLLNTHGVQEGSLPDKSDELLVLSEAGVYEAGGAPGDIVYATDILDHEEVTHASYVTTQVDYAGHITHADYPHHEEVTGSEDLHQSAVQMGLSEYVSSGCSTDKDMTSDCLHLPDSELIGAEEVTVAAHYSLSSPPPTPTLCRAGDDKLVDSHHFSHPSDGMEDDGVGNGGTIGQDAHPHRTSLVGGVGGSGVSEGGRGSGPHQLSHSPGHQEMHMDPMMECDEEPEKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3H7</accession>
    <name>A0ABM1W3H7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101858984 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829220.1">
        <property type="nucleotide sequence ID" value="XM_035973327.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858984"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026091">
        <property type="entry name" value="HPS4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407:SF9">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 4 PROTEIN LIGHT-EAR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="959"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829220.1"/>
        </source>
    </evidence>
    <sequence length="1196" mass="129191" checksum="6AEEB193C71B191C" modified="2025-10-08" version="1">MASRERKSSFRHEGHMFFIYDHKMKTEEDDPKDAILYFYPRSVDVDVQIALVGGLIGLADFCTEFLPQCMPSLVKLAGHNFALLQHEDFVIGLAGSPDIPDKFLVSHMQYVWSTFIFYQGSLLALKERVSSDHFLRELNQVWDMYVPLCQLRGDILSQAFQILPYVQLHKSQGGLFLHASHILQRSLRHKGVIAGALFSRNRVLCSQLSNSLTRKLLFLMSHNQFPCVRANSSVLELPGGVRLLYVFLPKEERDSLGQRRSKQFGRSASSLSQDSVEEDLRKTPLTSAAEKSSPFSSQLLKNSNPNYLFSDSAAGTSSEPRDKPSRGGLRMKSPTSAAITSGTDSDVFLDTLQDIQLDGHHNNVKLADIKEVQCRVSGHTSHHQPGSAPATKQDAFTSSSDTVTPHLTNLTVSVEVHADGDTAANQNKPAGLSPGLGNTRDSFSADKSVVDIPVISGEEAGACTEKGQVLRSSHDPVSARDGEDRDAVGDLRPDNNVGNKEIPDGGDLKTDFDDADDQRQDGGNTKQPPTPSNDSCNTQQVNHISSSSSENSTLFPTLESENVKENIENAHGKGGEEQMTKAPKDRNECSSNGHQGESLTDNKVNGLPVVNDVLGGGSGGHDDEDAAQSGSSVDPAVLPQSDDSASRSNCNPAVLNDNTSAESSSVCNSFTGKDQFKSIETTGEKILNEKKQEDESQASAESDSVSVVDNEVTAVEIPRTTSPDADADTRPQVRKQLNSTDGSGDHSQVGGADTQNLSSTGQNQSTDSPVIDVAGKDSGLENVPLDASPRVTDSPVVSENKTAGGGGAQTDGADNVTKTSTGTVCWASLPHEGWQERNAGNNNVFEGHMSEENAINVRKALVQSKEEIDASLDTQRCSNSGEDSSNHSEQKLEDLDGSQLSLTKGGNDGPPSKDRLTFEFLDSENSEGGIMSPFSEHGRLSPVAEQQDPKVGQKFLFPGSGSEQEGGQRSQGAERSKTAQFSVGGNLSSSEPARTATTTAASPPPQRSPKWDATSNGLEELTLYVQGHSDTLLVLLLKRSTNCSKNYINSLWKSCLSHLAELDFEVKDAERHMKDDSENLGASYQFMKYDPLTQKLRAFQKKQGSALQPVTSLANEIVDSCVQMHESFTEMPDLQDVTFRSHSASILGHRNASSETFFQTGLPRSCAGISTPGDKTFVLDQEATRVLLGDCDITML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3X4</accession>
    <name>A0ABM1W3X4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013778</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829367.1">
        <property type="nucleotide sequence ID" value="XM_035973474.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013778"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829367.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32757" checksum="D07F220156E527B7" modified="2025-10-08" version="1">MLSTQRSYGDESGSVTEDKPADREEEVILGEIEGELNLHVKVREIEMVCPGYEHCFNQTQSYNARAMSQALESERRSLVCEGSRLNILCLDDVLCGCGWGSDSVSRSTLRTLRHNHEQFCDEDLNIGYLNCNVENHRLRAGEIYCKAAIQPGPANTGLELGAEIQAQELSLAEHARNLDKACPGYERCFNVTQAYTVHAAAQNSAAEQLLISCEGSKFTVICLEDVLCACGWGDNDNFKTVLRDLRHQHEAVCNEDLTIGYLACSACSAWSSFHLTLIAVVVVGVSLLTQMRLLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4J1</accession>
    <name>A0ABM1W4J1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD-box ATP-dependent RNA helicase 42-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829584.1">
        <property type="nucleotide sequence ID" value="XM_035973691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856951"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829584.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="36147" checksum="C74F78409238822F" modified="2025-10-08" version="1">MPSENRRRKDDTWTPDELNKALKGPKDDMHRRKRKEDDGDHKRHREDVNGSDRRHGGDRRSHRKEDDDKKSRRHGDRGDSADRVALTEEEREKQRQERRARREGGKEEKKPKVRESKPTKVVIDDEEENKERRRRQKEDDRRHGDRKHNKEEEPRRHGEDRDGDRRHHDKDRDREKRHREERESKRRHEDEDEERRRRHKREEESSSRRHHGDSERRRRHEGGSDRRHGEETSSHRRRKEENDDEEERERRRQERREKRDSEGRKEKRDSEGRKEKRDSEGRKEKRDSEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4V4</accession>
    <name>A0ABM1W4V4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centromere protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101861182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829697.1">
        <property type="nucleotide sequence ID" value="XM_035973804.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861182"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009852">
        <property type="entry name" value="CENPJ_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026581">
        <property type="entry name" value="TCP10L/CENPJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058029">
        <property type="entry name" value="Tubulin-bd_CENPJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331:SF6">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331">
        <property type="entry name" value="T COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07202">
        <property type="entry name" value="Tcp10_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25779">
        <property type="entry name" value="Tubulin-bind_CPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENPJ tubulin-binding region" evidence="5">
        <location>
            <begin position="100"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1298"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1369"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1405"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1443"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="745"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="927"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="775"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="838"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="899"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829697.1"/>
        </source>
    </evidence>
    <sequence length="1488" mass="161266" checksum="A73F22359D647497" modified="2025-10-08" version="1">MNHQAQNLVPQKHRMGGGGGGGAQLIMNMDDVPDPRYIPRAVTFDDRNLVRSAQYDDEEGDEEWDDEDGDDVDDDDVDDGDDNEEDADDGDDTAKESVVHDERPIGGSGGKKSFEELLEEQLKEEEEKLRLDSQQTSGERKLPFLRKGEGIARFNSAPKKPPPRPPKRTLAGSKSAAKPPWVSGDAGGSGGGGGGDSVKSQGVGGQNRTGNVSKKDSVGNRLKAMSNGRPMERKGVRNGPKNVAASNFQKTARSPEHPPRKLTLIRSAANKKLEQQKARQNAEMETDAKLQRLVEDAQGRVQTLQVGSEKSGSRSPSGASRRSSRTDDHDSTELDSLAEFELMEEAMDNVSFCSNSSLVRKLVSSDYHKEAIGRLKTINESKKGITGESAEDSARGQNSRPGKNEKNNEELTEHEKAGATIKTQSAFFKANSDHNNINNNSNINENTSNSGSNNKKTLSSNGGGRNIQVAEPDSDASSSDATLTDSSDDNDDEFYDDKVEENKKEGFHRQQHQGGILQQGDGYTSLQNGLTTMKDSAAAHLSPELEQNFASYADKVGSNSQQTNSPSKALPRKVAPLAGKFSSANDTLSMLKALSQQAGYLTSGGGGAGDGGQKFDKSKNNSASLVAQAMSNGTADNRDPQVPPNFASSGAPFAFSAPNGASVVPVTSFGFTGLTETSQALQPSSLYSTMVQPTFTSAPSHHLGPESQQAENPLRSSLNKLYSSQKYNYNNGKSSAVVVDKLRNAAGDSDNYESEEEGNSSDDESDEYNSEEEEKLEKKKWCGEDKGKISQRLVEETGSHSEGKKVSTGTAERSGTVHEGAPGRLGSRSVATATAAAFDDEVEWTDEDEDAQTCLKSSSEPAPVPMSEGTMLSTPPTSRLVTRLFPKLKTKPSAEAEKASAALQQASAAPLAQSAQQQQQQADGIQSRVLRDKLKELEVEIERFRSENANLDRLRREREEGLSKLKQEIETFQKEKEQELKRLEDFKQEEIKKLKRERKLFETYQKKVRSMPDKKEREEIENLRQQLEEVQEELKRKESRWNSSTARLKNRLAEVELENGELKEEIRILERKRLEWMTAQSNAKVAGQQVNGKVSLEGSTVKSGGGSRAAQAGSSFPRSSTPTHEQDEPAIKSAPAGSNVKAPSEKGNLGSTAAQRPLTSGSSSAGSKIPAPMSGLRNGHPVVTNRPQGAMSRPQGGGVSEQTVLTNGRNGGGAGGVAAAVTQSVLAPPTAHSGLSGDGMQTENGPVPVMMENTIPNGVPAASMPGTRSSAVLDQTSKSAAALAIERAVVDKGDSAAYSETQHGDGKLEKTYRNGAKEIRFPNGTVKEISADGQTIVCRLANGDIRQIFPDHRVVYIFAEAEIMQSTFPDGLETFHFKNGQTERRYPDGTVEITFPTKDVKYLFPDGGQEVILTDGTVMQYNSKGERTVEYPSGDREVHTAEYQRREFPDGIVKTVYSDGRHETRFPNGRVRMRDKAGNVIMDQIVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAU9</accession>
    <name>A0ABM0JAU9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101847230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005089459.1">
        <property type="nucleotide sequence ID" value="XM_005089402.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847230"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF63">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 10" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="11">
        <location>
            <begin position="479"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005089459.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="70356" checksum="D22342AC46DD7A75" modified="2025-10-08" version="1">MVRLRRSRLILILVVFSIFFWFVLYWNFLGVYTRHKQRLLSKSGLHDKLPNDEFPFDYGEVQNEQDAIKNNEIEIQPGNPSKRKIYDESYLQQLGKINTAQDQRNYDAGYHNHAFNEMLSAKLSYTRPIPDVRNSKCRKKHYPVDLPSASIIICFHNEARSALLRTVHTVLARSSEHLIHEIILVDDFSTFEHLKSELENTISTLPKVKLVRSPERQGLIRARMLGAEEATGQVLLFLDSHCEVNVGWLEPLLAVVHSDRQTVAVPLMDIVDSDTFYYEPAGLVRGGFNWGMHFQWDPLPLEDSRAVFSKADPFVSPTMAGGLFAMDRKYFKELGEYDSGMDIWGGENLELSFRIWQCGGRLLIVPCSRVGHIFRKRRPYGSPVRDSFTKNTLRVVHVWMDDYKKYYFHINPRAEDMEYGSIKDRLELRDRLQCKSFQWYLDNVYPSALQKLPDLARSLYPTNSEKKINSAPEVAIRAWGLLKHTGSGLCVQSEKSIYDKRSLLQLAVCKHGKNEDQLWYETEQKDLRLANLLCLDYNREEGPYARLMKCKGSNPQTWIWSKRETHERLLNYETAQCLTATGIEPGALLKTMPCNDSPLTHFELFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JB83</accession>
    <name>A0ABM0JB83_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101849508</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089662.1">
        <property type="nucleotide sequence ID" value="XM_005089605.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849508"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KY-like immunoglobulin-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089662.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24766" checksum="E711B3B4DFB6E127" modified="2025-10-08" version="1">MAAERPELPAGYLGSQPKFAELNLQAQSHSSPEFSLDINEVEIKLRSPKPVKVTTNLISAKDDKEHSEFVFTQTKDGVLSFVITFPESGFYKFQIFALEATDDSKSLPNVFNYLINVQEALKAAYPFPKQYAQWKDGCYLYSPIVLNAKTSLAKVDFKVFVPNAKAVAVVAAGEWFHLAKKGDNWEGQASLSKHRGKDVKVTLNSNYGGDETKYATLLEYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBA9</accession>
    <name>A0ABM0JBA9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM219A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM219 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089729.1">
        <property type="nucleotide sequence ID" value="XM_005089672.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863707"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029339">
        <property type="entry name" value="FAM219"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281">
        <property type="entry name" value="PROTEIN FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281:SF3">
        <property type="entry name" value="PROTEIN FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15260">
        <property type="entry name" value="FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005089729.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19219" checksum="B764CF28DB9B9B73" modified="2025-10-08" version="1">MDNNMEDSGFDSDQKSHNNGYQPVPTKPLAYKALKKTSELQKKIERQRDMARRSNSVPIDQQPKKTSFVSRSRLTVPSSNSRVTQKDIDMDGSSADQQPLVAIMSDDSEEDEFDIPRLPKAAQKEITEQLIKDGYNLDLEPDDEDLDLIPPRPLNERCTCCGVPSNCYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCL8</accession>
    <name>A0ABM0JCL8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101863229</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101863229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090609.1">
        <property type="nucleotide sequence ID" value="XM_005090552.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863229"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF25">
        <property type="entry name" value="CNMAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="105"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005090609.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="48606" checksum="73FD83F8BBAFC8FC" modified="2025-10-08" version="1">MSTVTSLVYPEGEKSAFPLDGVDFNSSLYFDITSLGNVTGSIIGHHGDVGVDGNSTDILFINGTRRMIPGYNTRRPFSSYASLHRTMRLLTIYTCPIILVLGLLSNILAYLVVTRTRLRKVPSVPYLAAMAVVDSGALVTDFIQTGLLAHGVNLIGMMGVCQYVTFLHFAFLFLCVWYPVALCVEKFISVYCPLRKAGLCTPFRAKVVIISMAVITGVCFYYVIYMVGVQETLRTSLCMPFEHFHKDYNILMKLNSVFVNLLPTAALIVLVALIYGRGYEYYRISSAAEVPGRQGSTRNSSNRSPYRVTNVIFPVVFVMLILKSPTGFFQVYGNMKPPEQVPMIFRHLLPVFLYIDRLNLAVKFYVYLAFSPSFRRRTRSLICGFRAKINGQCRRNSSDDEIDAELASGGIPRITMTQRGNHFGASKTCRMASNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDK2</accession>
    <name>A0ABM0JDK2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101862090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091239.1">
        <property type="nucleotide sequence ID" value="XM_005091182.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862090"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023611">
        <property type="entry name" value="mS23_dom_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019520">
        <property type="entry name" value="Ribosomal_mS23_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10484">
        <property type="entry name" value="MRP-S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS23 conserved" evidence="8">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005091239.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19793" checksum="A3D33361C1D39960" modified="2025-10-08" version="1">MAGSRRESVGSILTRLQGLLRAGAMKAEDRPIWYDIVKAKPPKPVPPHREVQKILYPEDFVRARFYKTYADPGATVLSNENSKSIPQKFVDRYLELHGKGETEPSRLFEETTQSLAAEGVRLITHEERAAARGKSQVTNKSQASAVTPETTEPGTSEKVKVKSPSQKVDIKGLFDEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDQ0</accession>
    <name>A0ABM0JDQ0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protein NEDD8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Neddylin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091297.1">
        <property type="nucleotide sequence ID" value="XM_005091240.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854387"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005091297.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9184" checksum="D37C03035DA3CE42" modified="2025-10-08" version="1">MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIFSGKQMNDEKTASDYKVAGGSVLHLVLALRGGWHLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF98</accession>
    <name>A0ABM0JF98_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome non-ATPase regulatory subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092362.1">
        <property type="nucleotide sequence ID" value="XM_005092305.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857388"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="222"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092362.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="46842" checksum="2B8617432BEBCF37" modified="2025-10-08" version="1">MAAVALMQQAIDLKRTNKENATEILSTIVKQDIPQADDEAIKVKEQAILEVGKLLADQRKANELANLIKIVRPFLNMVSKAKAAKLVRALVDLFLDMEAGTGSEVELCKECIQWAKDEKRTFLRQSLEARLIALFFDTKKYQEALQLGSVLLRELKKLDDKALLVEVQLLESKVYHALSNLPKARAALTSGRTTANGIYCPPKLQAALDQQSGILHAADERDFKTAYSYFYEAFEGYDSIDSPKAVTSLKYMLLCKIMLNTADEVQAIVSGKLALKYSGPEVEAMKSIAQASHKRSLADFQKTLVTFKAQLEDDPIVNAHLKTLYDNLLEQNLCRIIEPFSKVQVQHVANLIKLPVATVEKKLSQMILDKKFHGILDQGAGVLIVFEESESDKTYANALDTIHNMGKVVDALYQKAKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFD6</accession>
    <name>A0ABM0JFD6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRAME family. LRRC14 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092428.1">
        <property type="nucleotide sequence ID" value="XM_005092371.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852829"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050694">
        <property type="entry name" value="LRRC14/PRAME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224:SF37">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224">
        <property type="entry name" value="SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092428.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="58763" checksum="A2FC21E474A12FA5" modified="2025-10-08" version="1">MAGAPMQGSQCLWYDHYKGSLFPLDLDAPPSCEQNRTSTSSLLEICCSYVVKDAAMTRAAIDCVPSILRVHMMEAALKGNHDRSIQALMSRWSLQSLVLSRLVPSVFTSLLPLYRPVYQSDLVRQGLRYTTALAHTFLECLRQVSSTKIRHLDITGFPTAEVILYYLCSHCMLAHNERRRNNMITLYNQALHLAQECHGSTPDSHSPLDTYFQNCLPENISVEIKLDAFVTSESCHSELCKALTVSAFPETRFRLVVERLSITCLGGERVLLLLKQLRPEEIRGLQLKYNSLENSHLLLMAPTLQSLTQLTALDLSCNHLNLYQASSALILQQVFAPLVHLRRLDLSNNRLKNQLATILSGISHPLQQLCLAACGLTPADVGALATCPHTLSLEELDLSENSLTPCYVSLGRILANISSCVKVLELENCRFTDEIVMSLTIHFSGFQNLLFLSLAGNTWTTSTVLTLTKGVAKLKKLKVLQLSYPYECHTDEASSEELELFKATVASLLEADDLLHTRPNKVELVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGJ1</accession>
    <name>A0ABM0JGJ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing factor CWC22 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101848806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093185.1">
        <property type="nucleotide sequence ID" value="XM_005093128.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848806"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1023"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1272"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="666"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1275"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1350"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1415"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1462"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1501"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1735"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1771"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1795"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1846"/>
            <end position="1866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005093185.1"/>
        </source>
    </evidence>
    <sequence length="1866" mass="210482" checksum="028BB85343837631" modified="2025-10-08" version="1">MPRKRRSSSRNDSDSSASEDSSDSDSGSPDDRHSRKVSDTKKSDKSSRRCSSKQSPSGARKDKDGDRNGNSDRRKVNRERDRSASSSDKRRSKEPSHKEESRMRGSDRSGSRRNEREDSLDRGKGRRDDKSDKRRSERTEDSDKHRAQRGDRSVERQSDRRDDRQRNDGRDTEAGEKRRDAGKGSSRRDKDNSRDRDSTEKDVDTRRGKRIEDNAEREVSVEDDRRKERRDKTSGDKMSDRKDKEKSSSSKSREKREDEGGAERSNSRDVQREAREKSKKKSKREESESESGSPSRENKSVSKRKVKKVEKEKGDSSSSSENSSSSEPESTSDERKTEASLVPYGDAKKGQVYKRSGRGVGRESQEEDSVRIASKKKGRSTERHSVGAEEGDDPDSSSEAEAVRSRKSKNSSKSEQADVSGSKGLPDRNVSRSDDSKRRQEAVDFEEQEKHDSTPERDRSVKDDEDLKKEQEDDQEKEEGEISEEEEEVLEKPLIAISEDISDISSDEESSSKPQRPAPPSQLGMAPEMSPGSPGTPPPEEEEKADSVTKESRKAAKSGQAGGKDSSKKSGPGGESRTRSMVQVVSKASGRSEERGKEEEEGEVAAPSQRERPQLESESEEEEEERRHRHGGKMGSSVSVVRSAGRDRGASPPRERYSGGGGSGRYDNRWQDRHDRFERSRRERSPLERRRDDRDRKRHNREDDEGKSEQTSPKKDNDRVKDAKESRAKKPEPKLVGGIDITMRTGGAYIPPAKLRMMQEQITDKTSAAYQRMSWEALKKSINGLINKVNVSNIIEITKELFQENIVRGRGLLARSVIQAQAASPTFTHVYAALVAIINTKFPQNGELMLRRLILMFKRGFRRNDKALCLSSTRFIAHLVNQVVAHEVIALEVLTLLLETPTDDSVEVSIGFLKECGQKLTEVTPRGVNSIFERLRNILHEGQLDVRVQYMVEVMFAIRKDGFKDHVSVMEELDLVQEDEQFTHLLLLEDATAGDEMLNIFKEDPNFAENEEKYKALKKEILAEGSSDEESGESSGSGSSDSEDEEEEEKEQQRIIDQTETNLVALRRMIYLTVQSSLDHNECAHKMLKMELKPGQEVELCNMILDCCAQLRTYEKFFGLLAQRFCQIDKKYIEPFQQIFMEQYETIHRLETNKVRNVSKFFAHLLHTDAISWGVLSVVKLTEDDTTSASRIFLKILFQELSEYMGLLKLNERLKDATLSVYFTGIMPRDNPKNTRFAINFFTTIGLGGLTDDLRDHLKVVAKQIMQQKQEAEQAELAAAKSASSDESSSSSDSSDSESSSASDSEAEPKKKRRRKSPEKSGKKSSKTSGTKKSDDRSKHRSKPGNKSESAQRKPDDSGAKVGGKSGKKSLGRDAEINGENRSGRRTIADRLLDMAQYGQARGEDTSNSGGGGQRDGEEGRRGRPGGEEDRGKGRQREDEDRRERRGNQEVLENRDRRRGQSRGEEDRKRGRSDMEEDRRGGRSNEEDNRKGGRGTSNEEEDRRGGRGRSNEGDERRKGRGRSDVEEDRRGERGKRMEEDRRGGKERPAAEEERDRGRGRRTEEDGNGRGGRGRQDVHDSRERNGSTRERGRDRDSSGRGRERSLEENGSRSYDRRQEGNAGRGRERSRDNRMEGRAKASDYFNDGRKSEDRSHERGSDGLARGRPDRKRGAPEDDQSRRTSREDPRRGSKEERKGKRKRGRTSEEEEESESSVDRSASRKAKQARVNGSAVRPSESHKGGRGDKSKHKQQEKHSKEDSSSGSDSDNSSEESEKDRRKSSKDKVNTSKQRKRKSSVSSSKGSGSSSSSSASSSSPSSSSSSSSDEEADEQEKRIIKMKKGGGGGRDAADRRERGRVGRDRSRDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHG8</accession>
    <name>A0ABM0JHG8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dynein regulatory complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101857629</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093754.1">
        <property type="nucleotide sequence ID" value="XM_005093697.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857629"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033551">
        <property type="entry name" value="DRC7/lobo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056292">
        <property type="entry name" value="DRC7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056291">
        <property type="entry name" value="MORN_DRC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249:SF2">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24671">
        <property type="entry name" value="DRC7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24667">
        <property type="entry name" value="MORN_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="12">
        <location>
            <begin position="184"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex subunit 7 MORN" evidence="13">
        <location>
            <begin position="448"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex subunit 7 C-terminal" evidence="14">
        <location>
            <begin position="781"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="708"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005093754.1"/>
        </source>
    </evidence>
    <sequence length="889" mass="103460" checksum="2648785F46B4DA9F" modified="2025-10-08" version="1">MESETQPEPSAEGESEKLVSDAASDEKPLSATGDVGDGDGLNLDGQENGDGEEGQEEGEELTEDAEALKEVLDTIVVVPPEPEVPVQPAEIFDPAEFPSSYKDNLPKELMVLQYSDNFRRQYVHLYRDRKPLLLSPVNECGVEKFVCTTIRPSQLPFKELYNWEGAAEFVSDYLNFETLDPSYELPTRLLSPATVLKRQKGNCFEYSTLLCSLLIAAGYDAYVVSGYASRETCLADESREICPLMKKKEEEKKEERKKQIKKYTVKPPKDLRSRFELKMEARRVAEEKAEEDKRRAEEEQKQAELEKPPPDPLHGLRIHSWVLVLSGKREVPESFFIEPFTGLSHSTGSEAYLGIESVWNHLNYWVCMQDCSEGVHKLSYDLGDCTMWEFMFPGVDKAQLLIPEAEEDPLDNLDDDEDKEEEEDHLDMPPSWVEPLRLSQKDFEMRCPHGKKTKLYKRAKLEKFAHYLMTDGLVSRLSVFEDKELNDLKMVKEYYEHRSDKLSMRIHNHRTGWVTEHFLAGRPKCVKEHCYKASAPGAENDRTMIFYGEARVDGLVKRVETPVSMTEQYQNRDDFQYYKHIDFGKRVKKFGPQDEVVANNPRPIVKMIQRFERNQAKPANADIKELIFLVSEDKIQITYHTESIHIASSSREYIKPPNWDEKGATLSWSPDMHGTFQVDPSAEPSKQVELYQNLLLLLKMEETCREGVRESEEEVKKIIDDRQAEELKSELDISVYDTERNEKAKKHRRELERQQLEEKMRKQEMEIDYLAPFLAQMGDPEKIARNEAFKLKEDCLADLKHRLIDKANLIQSRFEKETQELQKKQAWYQQNQVSMSKDDEEEYLNYCSEAMFRIHILELRLNRHKEMAPHKYMALEQKLRTDPRLAEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI07</accession>
    <name>A0ABM0JI07_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101851717</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094081.1">
        <property type="nucleotide sequence ID" value="XM_005094024.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851717"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046927359" evidence="2">
        <location>
            <begin position="22"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094081.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="61729" checksum="A1C4F47445A27A40" modified="2025-10-08" version="1">MGGFVWTTLVCSMSLVIATNARRSNQSPADMKNMQIDINVLSNEFDRMNQKLDILLSKVGGMEEWNKVEPGWPPLTLLNVSHRTTEDDGAVLTVWYQTQSSCNDVRSIWTLHAFWFKIIPFNESELVDSSCTCVHHSCLGWSSVTVEGPIGDKHLSLVLKDTHYNFLYKMKLNLKPKVPAAEAVRSKLFFMNSEQDVVYSPGKDPIIDMFYSTPEGKSGDIRLEVELENLGNSTGEMRLEKQSVSVNTDAWSSSKKDLCIIENEKHFLHFTRFQLRINSTKVEPLGFVTVNAYNGDFDNGPIKSLSVLQKVTIHKSTQKQPYPEKFLQLDAISYRCTLGDNECNIFCDAVGNHVRDIRLSPAIQNNTKSTVVSEIIDINSNYRISGYWSIETPRYVTTLDYECSVTYEDNATSSTNVSITVVDVPKILLNESGVSYNDDNHSLSVQCAARGGPHLQLSLSISMHGEGGMDFSYINIHPSQYAQLEQRPGYVIKNFQIPLPDRTGSGQSPVSTLTVFCHANVLDFYSFRDEAILVKNYSIPQRDNQTTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI93</accession>
    <name>A0ABM0JI93_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RING finger protein 207</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094247.1">
        <property type="nucleotide sequence ID" value="XM_005094190.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849117"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19814">
        <property type="entry name" value="Bbox1_RNF207-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039320">
        <property type="entry name" value="RNF207"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22635">
        <property type="entry name" value="RING FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22635:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="604"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="737"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="737"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094247.1"/>
        </source>
    </evidence>
    <sequence length="844" mass="94615" checksum="341024DE2D18528D" modified="2025-10-08" version="1">MSGEIFQPMESVEESSIAGTRNPLLCYLCNDPYEDPRILGCFHSFCALCLRGRASDGKMTCPLCGFAHTLKEGAVLPPSDLLLKFMVESTTEEKAQCANCDSTSLQMFFCNTCTQPLCGPCREETHRAKMFSSHDMVLLTKRAREVHKKCALHGEPYIMFSSEKKIMLCINCFRDMRIESRGHCLDLETAYKQSCKKLDLRVQAFRELQNSVREGVLLFRALLEEIKTNAEKEKTAIETLCTELLAKIEDTKAILLQKVCTEYTNKEATFHSQLKSLSALLPTLQLHLVISSAISGSANKFEFLDLTYVLMDRLKSIVQKQHPLHPTQSGQIDTSHKTEFFKSLEPLLYVPLQRNVLAPSVQTNSVTAVTTATSCPGSPLAHRVTPNHTRRANGLNGAKVKFIDAKGSFAEHCREFENAHRDLMQRFEQMKVQCQELQRDLTMRRCLANKEEVMGLSNNIELVQGQLDTHYSTLEGKLPMLEKHWEESLERINNEQDLFHAQLQDVMRLKHESQHLRVIASQLTSFVSSIAAVTERLAPKLGQTSQSSEQDMQMASLLEEINAVQPDSQQRVDAIRGAEEERQTILASRTNPLDDELIKTKGLLRAPSLRDKKGERRRREKEPAEKAEVSMDRERDGENGSPKTSSPPSTCESCAATEVEVKASGGQQGEVTLETASVEMPDICTESPPSKQCENGEVDAYVVLTLEKDSGVQSKTNDSVTEDKARISVVEDVEIPTVREEKRNRGTDKDAEIPTLREEKREKRNRGTDKDAEIPTLREEKREKRNRGTDKTQGGGGGCGDASLRTSTDVDSEVIRNLLKDIENVRKRDSLSSPKRLAQGGDCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIA3</accession>
    <name>A0ABM0JIA3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein C2orf42 homolog isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein C2orf42 homolog isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101855089</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094270.1">
        <property type="nucleotide sequence ID" value="XM_005094213.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094271.1">
        <property type="nucleotide sequence ID" value="XM_005094214.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855089"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026049">
        <property type="entry name" value="C2orf42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029269">
        <property type="entry name" value="Zf-tcix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13518:SF1">
        <property type="entry name" value="C2ORF42 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13518">
        <property type="entry name" value="PUTATIVE TREBLE-CLEF ZINC-FINGER C2ORF42 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14952">
        <property type="entry name" value="zf-tcix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005094271.1"/>
        </source>
    </evidence>
    <sequence length="646" mass="73143" checksum="76E2FB09C34EB916" modified="2025-10-08" version="1">MQGVSTMATNSESCTILDKRKHPFGDLGKPTLRGVRKCPKCGTFNGTRGISCKNKDCDVVFKERERKKGHSAESVKIITESTSQLYSVRLRDRGPDYRGFVQLPYIQDMEGNPAPVVDHSMLTGAAMCYVESCNRNAPPDPNSILKGTAPTCVHVRSAIDCTQQAQPITLKNEIFNNLQISNEMKQSIWLLATETSGPVVQRVTKNIMVVKCKITSKQPLGFLHCAFFETIRNRQHPDYKFQCSCRTFKMRNSHAREDVSKRCVHFYACICAFASDEKLSKEFAPYMNPDQPVMTLTLMGSDRQVLTMYQPIEESLAVPADADTMEFIISEEDMLVVTPDKKVKKEDPVAQASSALLTLQEQKQPSQATAVLSTLQSTSVKQSSHTTQFQIQQQQQPQQQLTQQQPAQQQTQKSTPKKLSYQSTVDENTASISFQQWLASVTERINQTMHYGFSGTPDPLVFHAPQVFFDCLQQRISTGTRKKRLPNYITSFVRKEALPLGNFTKYTWHITNIMQVKQIFDSQDITLDLSRSFVENRDGTYDPYEAPRPDVYGDASKIKNHLPIRPFELKTYLKVGPTADQKEPVPFIIEWIPDILPRCHIGELRIKFEYGHQRNGQIENRTSSSLPSSDVSLHPQAIQLREIIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIN9</accession>
    <name>A0ABM0JIN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lamin-B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101851857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094526.1">
        <property type="nucleotide sequence ID" value="XM_005094469.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851857"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF11">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="9">
        <location>
            <begin position="58"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="8">
        <location>
            <begin position="446"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="55"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="310"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094526.1"/>
        </source>
    </evidence>
    <sequence length="595" mass="68198" checksum="23B0E12CAA2F458A" modified="2025-10-08" version="1">MKQTRKTVTTTYSSSSGGGGGAGGEEAGTSFSSSSSQSRRSGGLGRPPSPARLSRIQEQEELQGLNDRLAAYIDKVRSLEAENSRLALQVRSTEEVVKREVTSVKTLYESELAELRRLLDETSKEKARLQIEANKYKTDYEDLLAKYNKRDRDANALERRVQVLERQLAEFSARDFEKENQNLKNELNRLEQQLAAAKKQLEEETLLRVDLQNRVKTLKEDLHFKSQVYEQELEESRVRTTTQLEEVDGRIEQEYEARLQDALREIRAQHDYDLQSVKVELETLYESKVEDLRNQLERNSQSSSAAWEELMLARRSVDDLSAEIGRLKSENAGLDLRVKDIDKQLERERDEFRLRMKQRDEEISRLRAQVEELEREYAALLEIKIKLDREIEAYRKLLESEETRLNISASMTEQRSMTTASSSSGGRKRKRMDIGQAVEEYTQRTASSGFSRSATSSCGVDISDVDTDGKFVKLTNTTDKDVHLFHWQIRHVSGDNETRHKFQKNVLKAGQTITVWSADSDQTHNPPSDLVMKGKRWFVSGDMTTTLLDQDETEVASCSMSRNIGSVASYSTRRRGPRDELDGEELQDKDKCFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ54</accession>
    <name>A0ABM0JJ54_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ceroid-lipofuscinosis neuronal protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094845.1">
        <property type="nucleotide sequence ID" value="XM_005094788.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863499"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029255">
        <property type="entry name" value="CLN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16244">
        <property type="entry name" value="CEROID-LIPOFUSCINOSIS NEURONAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16244:SF2">
        <property type="entry name" value="CEROID-LIPOFUSCINOSIS NEURONAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15156">
        <property type="entry name" value="CLN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094845.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36794" checksum="33F6EF22CDD1DF00" modified="2025-10-08" version="1">MARDDSGQTKQRRKQKSDDRVVNGPQKTGNMSKDTKKRLDTKTRQMDESFHADLWFILALDNWIFDFGRPIAAMFVPLEWTPLDKPSIGDYFHMAYNILTPFCLLKLLERSKQRVSSTLTYVSVIVLVMGASIHLVGDSVNHRLIHLGYKNHLSVRDNPIMQEIRPKELLKSFELLYRYDEEIGHLMWYIPFFLCLFLYYIGCFSSGTRRSGISFSWVSLVLTSGTYYWYLATEGQIFPLFLLTYVCMLVTYAVQRGRGLTSDPNGLFLVWTFTLTVTLTGLWSVWLWNDPVLRQKYPGLLYVPEPWAYYTLHLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJG6</accession>
    <name>A0ABM0JJG6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005095060.1">
        <property type="nucleotide sequence ID" value="XM_005095003.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853775"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="37"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005095060.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26135" checksum="B6EFCFF0FE44D420" modified="2025-10-08" version="1">MFFCLLRSSIPLKTFGSVLRSSPVLFASQTRAMSQSLRPIVISGPSGSGKSTLLNKLFAEYPGCFAFSVSHTTRNPRAGEENGVAYHFVTREDFQNLIAQNGFLEHAQFSGNLYGTSKKSVNDIGSSGQLCVLDVEINGVKSIKNSDMQPRPRFIFVKPPGLEELKKRLQGRGTETEESLQKRLDSVKEAIDYAEESGAYDHIVVNDDLEIAYEHLKGILIEDITKLQTSKLKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJM7</accession>
    <name>A0ABM0JJM7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triokinase/FMN cyclase</fullName>
            <ecNumber evidence="2">2.7.1.28</ecNumber>
            <ecNumber evidence="1">2.7.1.29</ecNumber>
            <ecNumber evidence="3">4.6.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101846276</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>FAD = riboflavin cyclic-4',5'-phosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:76202"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.6.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Interacts with IFIH1 (via the CARD domains), the interaction is inhibited by viral infection.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.28" evidence="2"/>
    <dbReference type="EC" id="2.7.1.29" evidence="1"/>
    <dbReference type="EC" id="4.6.1.15" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005095200.1">
        <property type="nucleotide sequence ID" value="XM_005095143.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846276"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011049">
        <property type="entry name" value="PRK14479.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="17">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="16">
        <location>
            <begin position="385"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005095200.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="61137" checksum="4387C7C49E5E060E" modified="2025-10-08" version="1">MSQQVATKKLINEVSNCERECNEGLVAVHPGLSLVDGETVVVRSDAADVTAANKVILISGGGSGHEPGHAGYTGKGMLTASACGSVFASPPPKCIMAAVDAACGQNKNCAVMMIVTNYTGDRLNFGIACERARVKGHQTEMIVVGEDCALDSVDHSAGRRGLAGTMFIHKIAGAMAEQGMGLAEMTSELNKIKSRMGTMGVSLSPCSVPGSGPNFTLQPDEMELGLGVHGEAGVKRIKVLSAKETVRTMMDHMTNPQSSTHIDVSSGDRVALMVNNLGGTSVLELNIVAKEAIEYLERRGVSVERAYCGTYMTSLEMAGVSITVLHIDDRIRAFLDFPTDAPGWKSCYLPPGATVRITPPLVKVQLDDQILSDAGAGKLDAAASALVYKSIKHVCERLVSSEAHLNDLDTQSGDGDCGSTVARGARAILSKLGSAEQPGLPVDCPLTLALRLGQIAEDTMGGSSGALYSLFFTGASQELKTLTADSLAKAVDSGLKALMKYGGAKPGQRTMIDPIDAASKSLSQNSQLSLSEAVKVAAKASEAMAQSTAGMDAQAGRASYVNKELLTKPDPGAVAVAMWMTAIADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJP6</accession>
    <name>A0ABM0JJP6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101858618</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095251.1">
        <property type="nucleotide sequence ID" value="XM_005095194.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858618"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047356095" evidence="1">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005095251.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18115" checksum="4D45DC281EF38434" modified="2025-10-08" version="1">MASLTWLIGTSFWFLYAASCCSACQITIDNVGAYTLGPSGDSPWLKGGPFSFLFDSKWRSTDDGTLNFTGPVTISAGKDELSQYNSRSLKMAAGGVSMVAEVRTYPEYPGVVIFIQRFPQGLLGSRFEANKTNTAFPTFQMTSTEADLGYLSYGGMMLGDYAKSFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJY1</accession>
    <name>A0ABM0JJY1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Leucine-rich repeat-containing protein 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101856253</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095414.1">
        <property type="nucleotide sequence ID" value="XM_005095357.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095415.1">
        <property type="nucleotide sequence ID" value="XM_005095358.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856253"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005095415.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33112" checksum="6469634DAB0CF387" modified="2025-10-08" version="1">MALELFRRLIQMWREFRSQKNIDRTADFHSFVVFQDFVNNRVESDSDRLQVLHVDNTENDLVEPFYDIPINIGRFAHLTSFVAIGCNLRDIPWSIVYLKQLEVLNLSFNCLSVLPNYIGSLSNLKSMNLESNCLQALPSALLQLSKLEVLNIDNNKGLISPPYLVCKKGLRAIKVCLKNRSNHRNLWENCRAYYTAEEGNMPWSVSVQPLVVISVQCILASKVDYLCQTFLPPRLKSYLQEKEKEEKDGIQLAKCGDCGGYFSNVYHFEVHECKVSRNKGGVRASEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKM9</accession>
    <name>A0ABM0JKM9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101861202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095932.2">
        <property type="nucleotide sequence ID" value="XM_005095875.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861202"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045786696" evidence="2">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095932.2"/>
        </source>
    </evidence>
    <sequence length="165" mass="18445" checksum="0972642C7751D395" modified="2025-10-08" version="1">MIVRVVVIALCFASLVSSRAQGPPLSEKLQSRVKRNEVSEVPLPPGGNPPPLPEITSLGYRCPFPPNEDGRWPEFCYDVIGEQCECKADDVIFGLRQCVTDHGDLFDRLIQIQLSLEVERDNKRLELGMEADPQPYLAILQCQSEGLKIRKEMQTTTTTESTTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLX6</accession>
    <name>A0ABM0JLX6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101851797 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101851797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096757.2">
        <property type="nucleotide sequence ID" value="XM_005096700.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851797"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005096757.2"/>
        </source>
    </evidence>
    <sequence length="384" mass="44163" checksum="6A5437FE304A74FB" modified="2025-10-08" version="1">MLCTGLWDETTLKKDASCNKICLVMAANYQKEKPVSHTYDYESTDSEESDEEGLTLLQRAEHVRKSQGMFETEVWFGEEADSATLMKECKKNPGHYNFRHVSDFRQHHLPREYKERKLHRAIKTCADLTVKLSVFFTSRDRPEKYPGSDRLYPFYQSRGNFQYRRGGTGWVWKVEEYGEGKKEKSGPCECQECKGSDNPHKVWWEIIIMTAAHVVFDESECIKTYVTFWDEMKSKHCPVKLKGHGMGDSSIAADRGMFMCVTHDADFCRKLRTLCKRRAELTGYCDDKFCTNDVRGLSVVISHPHMDKKRITLGYGIARVDEELASYYSYDADTCFGSSGGFVWAVGWGSHHGSVAPHSYGYEKNSDYLFSTSHNKSGWSWPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM05</accession>
    <name>A0ABM0JM05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101846282</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096819.1">
        <property type="nucleotide sequence ID" value="XM_005096762.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846282"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032739">
        <property type="entry name" value="MRNIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049472">
        <property type="entry name" value="MRNIP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15863">
        <property type="entry name" value="MRN COMPLEX-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15863:SF2">
        <property type="entry name" value="MRN COMPLEX-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15749">
        <property type="entry name" value="MRNIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MRN complex-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096819.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="54386" checksum="872294095BB088C9" modified="2025-10-08" version="1">MVEFHVLQCADCNTFQVLQVTKTNKWKCKLCGSKQSVRKVYGRGTGADCRRHVQKLNTVRGHVDQELCDLRLERANNATVDSAEFHGTSGEYEWPKSGKNEQISKWSQFVESGKEEDLETEDQGIEEYSGSTGLVTTDWTELQGHRKQQLGLKRKRSGPPHVTAKQQKSQHSFETTPTSRDFWLPQSFSQVTAKASHGGLMSNRRVCSSVGLHTAVKSVGSVFNSSLELGADCDDSRVSHSATAVPDVIEQSNVSIRVRSLWALENGGSSQGLVKPVRNNTVSINKNNLLESEPQKNISTFHPKNDSTPSKSSDSFANSASRARDPTSLNTSRQFSTGNVKNGIPLNALNPISKSGKTENIKSVTGGNSKRKVQQVAASSKWGAFLDEDNSDGDDSDCNSDLGEVDGENGALYINVKDPNLLYKKSGSHLLSPAVDATNHLQEDSNDPSLIETPTLAQVSLPCSKQPPWLLKAVTVSESDPSTEDTGSFQLGFSLDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMJ5</accession>
    <name>A0ABM0JMJ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tumor susceptibility gene 101 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101856261</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097194.1">
        <property type="nucleotide sequence ID" value="XM_005097137.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856261"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="11">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="10">
        <location>
            <begin position="391"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="309"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005097194.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="50821" checksum="776383179E7666EC" modified="2025-10-08" version="1">MAQHEGLLKSYLSKYKHPVDTKTEIINTIKAYRDLRPSLEPFVFNDGTQRELVHLEGTIPVNYRGNVYNIPISIWVLDTHPYNPPMVFVKPTASMQIKPGQYVDANGKVDMPVIRDWRHPTSDLLGLVQILTFTFGEECPVFSRSANQRSSNQPLTYPGQTPYPSNPAGGMPMPGMPPYPPAGGVGGPSYPGYPPYSTPSSYPSGGGGGNPPYPAYPPTSQNNSYPPVYPPASANTPYPSHMPSQQPPGPPYPGSGGGYPPSQYQAQPPYPTANNVGNSNGLSQLTPGGTVTEDDIRASLLSAVEDKMKRRLRETFAQAQAEMDVLTKTQKDLTQGKQKLETIISDLEKEKNEIDRNIRLLREKDTEVKEAVQKMESNEEVDIDEAVVTTTPLYRQLVDAFAEEQAIEDAIYYLGEGLRKNVIELESFLKRVRELSRKQFILRATIQKCREKAGLPPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNK4</accession>
    <name>A0ABM0JNK4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005097885.1">
        <property type="nucleotide sequence ID" value="XM_005097828.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854948"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="38"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005097885.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="39330" checksum="A002506CA1916834" modified="2025-10-08" version="1">MATFCCRFSPSAAVKQAKTWSQLSRCLSTSASRAATQMHVRDALNAAMDEEIERDDKVFVMGEEVAQYDGAYKVTKGLWKKWGDKRIIDTPITEMGFAGIATGAAMAGLKPVCEFMTFNFSMQAIDQVINSAAKTFYMSAGTVPVSIVFRGPNGAAAGVGAQHSQCFASWYSQCPGLKVVSPYSAEDCKGLLKSAIRDPNPVICLENELMYGVSFDMSDEALSKDFLIPIGKAKIEREGSHVTLVSHSKSVGLCIEAANELAGKGVECEVINLRTLRPLDDEAVIKSVMKTNHLVTVEGGWPQCGIGAEIAARVMESAAFNYLDAPILRVTGADVPMPYAASLEQLALPQVVNVLNAVKKSLNLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP70</accession>
    <name>A0ABM0JP70_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Uncharacterized protein LOC101847584</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4 5 6" type="primary">LOC101847584</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098279.1">
        <property type="nucleotide sequence ID" value="XM_005098222.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098280.1">
        <property type="nucleotide sequence ID" value="XM_005098223.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098281.1">
        <property type="nucleotide sequence ID" value="XM_005098224.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098282.1">
        <property type="nucleotide sequence ID" value="XM_005098225.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098283.1">
        <property type="nucleotide sequence ID" value="XM_005098226.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847584"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33844">
        <property type="entry name" value="SULFOTRANSFER_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33844:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005098279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005098283.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="51698" checksum="230905BA06F4ABD6" modified="2025-10-08" version="1">MDGKTEANNHLEQFSKAMNMFRDRAIQILVYMLFQLTRTIVVTFQKFTWAVTGVERIRRDAARGLQFKQSAHVQEIFWKRKFFDHSVADPSNFITTHKGFRPPSCIFKSNVSLYCMTRREAVFVEVKESDNVYKSKHSNYLYQNQYHHAVNVITMPLASFHKMASDVGNPRIPVTWLSCTARSGATLVSQMMHRIPGMLSLSEPDAITTLGFLYKKKLIQPSEYKQLLASCVRLLCKPDDRYSAVFVKARPCTTSLVEDIAQVFPRFRYLFMYRNSVKSLMSNLSLLQQDPAPKALRFIMDSPVLSTFLPFVRSYFYYYHVFLNEKKVSSIVPTKLGSVGIITAAWAASVSQCADLRYKGFNIGSILYEDFMINPRRSLSVLLSLLDIRREHLGPAAEALKADVNRGTSHDTGVDARRALTPENRQEADNVLKAYGLAKLGERYEVSGLLKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPB8</accession>
    <name>A0ABM0JPB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger BED domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005098381.1">
        <property type="nucleotide sequence ID" value="XM_005098324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853618"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005098381.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20141" checksum="F93A889B5A1E8D69" modified="2025-10-08" version="1">MEDHLKKHHVRCYAHKLNLIVRDALKNSCELVELIAKVKSVATDATNLGRQQGKLIQDVETRWNSTLHMLRRYEEEHTAVTGALRALSKTIKSLTDEEVERIRAAIEVLTPFELATKEASTEKHTSVSKLLPIVRQIQEKLSGESPSALRDQLQAELRRRFGSLEDNFTLGAATLLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPQ4</accession>
    <name>A0ABM0JPQ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101854084</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098642.1">
        <property type="nucleotide sequence ID" value="XM_005098585.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854084"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF25">
        <property type="entry name" value="METAL RESPONSE ELEMENT-BINDING TRANSCRIPTION FACTOR-1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098642.1"/>
        </source>
    </evidence>
    <sequence length="962" mass="100524" checksum="5CFEDA8F536910E9" modified="2025-10-08" version="1">MEPYTDFVNDSNMNFDDFLHFEVEDDENLQDMSSITQVCVDHDEDEPPDDGQIHVSEGVCNKEQGGCSSSSRDDNSDFEARYTQEEGVKMEHTITSDNGDGYIHHTISEDEILMQINPGSSRLPLNPSHATLTVESQNPRTKAKEVTRFKCTFAGCARTYSTQGNLKTHEKTHRGEYTFVCNESSCGKRFLTSYSLKIHVRVHTNEKPYECDISGCEKSFNTIYRLRAHKRLHTGETFKCESDGCTKYFTTLSDLRKHIRTHTGEKPFVCHENGCGKAFAASHHLKSHNRIHTGGRPFECTQDGCLKAFTSIYSLKSHISRHERDSEKDKGQQPSSEKKSTAGGGGQCSGECHGNDNSADTGPDIVNFQNVVLVQQGDVSSSLPAESLQQGKVTLSAEQLFNSLYTTPVLNENLVQHGKGDRDCVGCDSVQEIMQPVIPLESCGEPQPIPIGLMTSSVPVCHSHSAGHLVAPTVSAQHILGSQLAVEAQGGVSQGTSLLLDTQGGVSQGTSLLLDTQGGVSQGTSLLLDTQGGVSQGTSLLLDTQGGMSQGTSVLLENQGGVSQGPSVLLETQGCVSQGQPVLLENQGGVSQGTSVLLESGGSSAILGTGGVEAGGSTTTATTVPDPNSLANIQLLRSELVKNILGTSNTIVVQTADGSLVQVPSSALLDQAGLASLVPGCLGANQTLAAANNSVCLPAAACHSTFLELSKPSEGGEVIASTMAANTALNGLSELVAGSSGGASQNFLLQPSGGSSSSSEATSGVFLPPTTMLVPNVASQSGQQQHLLRGQEGMGSGLSTAIFEVAATGQAVAPAAAVVGSIPNQTVVSNSVKRESNDGSGGSSLSPLTFVDPAAMSASQPNVDLTASSLMSDSCCHASSSSSEVFNSTVSTVSSGMVQAGPSNLVLPEDGTLTSAIQKGIPVSILPGANPESIVLNQVFVPVYSNTDKGPVIELVPIKPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPZ2</accession>
    <name>A0ABM0JPZ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Melanopsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101854018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098819.1">
        <property type="nucleotide sequence ID" value="XM_005098762.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854018"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="36"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005098819.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35947" checksum="E7646D7D05C6E514" modified="2025-10-08" version="1">MASDPGHEPSCALGSRQSMIIVSTIYICLGVFIFFENIITIMAIRRTPSLHTNPNLYMFSLAVSDVLVGATAIFLGSFVNPTVQDRVTSTFPYLASLAVTFGMVSLSFAHMAVIAVDRYIYIGKPYLYERCITRRVIFFQILCLWVSGAVYTIAPMIVYREVNVGFCILIDLPPEYTLYAIGIAYFILLVVVLIAYYKIARVVLQHRRSIANQTISLDRTGEDLRNRKRQTSALKSVRFFAVVFGFFFGFTLPTVFCMYIESVVDLPYELYAFLIFIAPANSSMNTLVFALMNKEFRKAVKKIFVDLRCLKVYESSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ94</accession>
    <name>A0ABM0JQ94_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101858182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005099009.1">
        <property type="nucleotide sequence ID" value="XM_005098952.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858182"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005099009.1"/>
        </source>
    </evidence>
    <sequence length="807" mass="90182" checksum="8084336DEA51DB5C" modified="2025-10-08" version="1">MEAEVWNQLSEDDVFRQFLDESFDVKAHANRAIQGMVISEQLGKLAEGISLLDKEIHSQIVNHHEDLLSQATGVETLEGVLQMMQTRIQSLLASMDRVRAKVSEPYSKIVARTTQLRHLQETCDLLRRMIRIMYLSKRLHTQLEGGAREITKAAQSLNELDYICEGVDLGGVEVIEQDRRFVKQARKEVESQAQKMLEQGMETQNQTAVATSLQVFYNLGSLHSVVDKMVASCRATLHQQVRACLDVQALTMSQGTVGRGGPGRAAMPSPGNTAALRANLWTNMEKLMDNIYSACAQVQHLQKVLVKKRDPVTHVCFIDEIAKHRHGDVNIMHDFWEDSTNMLTREFSDASQNSSFLKQAFEGEYPKLLRLYNDLWRRLHQFSNTLTVTPSAGVAEVVVTGDGDEDFFAQTEKSRQTYDSERALRETLALFENAYLSRSLSRLFDPINLVFASNTSSPPTLEEVDNVVKTISSELNVSSVDVKLSITVARNVAKTVKLLCVKSEQLLSTDGEASQVIGPASAGQTRNVGVVNTLFHFLQAVDKVLTGINHFPDEAQHSIEVALESVVQLMGAALQPLLSSISDALEAIILTVHQEDFSGPAPSGSETEAPCSLYMKELQSFISRCQADYLSQFKCKDFIMDSILPIACRCVELFVRHASLVRPLGDGGKLRLAADFAQMELAISPFCRRAADLGKTYRLLRAFRPLLFQTPEHVSQSPALGEILPYSTLLHFLFARAPTELRSPHQVSDWSVSRYSQWLDDHPEEADRLKIIKGSLEAYAKLVRQRQSKEYAAVYPVMLSVLQKGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQG1</accession>
    <name>A0ABM0JQG1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Laminin subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101850003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099143.1">
        <property type="nucleotide sequence ID" value="XM_005099086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850003"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="4">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="4">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005099143.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="29020" checksum="1367B4456A606165" modified="2025-10-08" version="1">MTNGVLVCDCEPSGTNPAALTTCDVLTGQCSCKDRVIARNCSECISGYWGLTADNALGCNECACNPQGTKGNTNMCDKTDGSCECKVNVAGDLCEQCKPNTFNFDPNNPEGCTECECDPGASVSETCELVGGQCTCRSAQLNGRECNTPVTGYYVPKLDFAVFEPETAANGNNIVLRPGDGDLGATVSGRGLVTLSPANQVTMDFTFSLPFTGLVDVVVRFEKTTADKIVYMLGKLTYTGTTGYQCQGQTVAAGQEWSLLSTDERDSVRDTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRN2</accession>
    <name>A0ABM0JRN2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase YteT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099970.1">
        <property type="nucleotide sequence ID" value="XM_005099913.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846820"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF2">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="161"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099970.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="49960" checksum="738399A0E42E35A0" modified="2025-10-08" version="1">MSQAQHTAEERMGNHHSKNTPNEEPLTCMIVGAGSRGTAYSRYSVLFPEQLKVVGLAEPHEGRRNKLLKLGTVPPENVFTDWHDAAKREKFADFVVITTVDQDHKDPAIAFARLGYHILLEKPMAVTEADCREIVSVCNSCGVKLAVCHVLRYTPWVCKIKEIIDSGDIGEIVSIRHTEPIGYWHFAHSFVRGNWRNEATSTFSLMAKSCHDIDLINHWMSPHRCQRVSSFGKLSHFTKEDKPPGAASRCVDCPIESSCPYSAKRLYLDFVKQGHTGWPLSVLTSEVDIENVTDALRTGPYGRCVYESDNDVVSHQVVNFQYDNGATVAFNMVAFTKRLCQREVCVYGTKGQISFEDGWDSVQVFDFLTEHIKQYSIRSEHPAKMGGHGGADYHMMKCFMDSLNDIDGKVATGPEETLNSHLLVFAAEKARLENRVVEIQPDGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSX2</accession>
    <name>A0ABM0JSX2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100742.1">
        <property type="nucleotide sequence ID" value="XM_005100685.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847499"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01794">
        <property type="entry name" value="Ubl_UBTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="157"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100742.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26120" checksum="60364946390805DB" modified="2025-10-08" version="1">MGGCIGSQRDSGTGESSDLDAGWLQHVSVGRNQPLKAEKPRWKNDVPLTEGQLKSKRDEFWDTAPAFDGRKEIWDALKAAAYALETGDHTMAQAIVDGASISLPHGTLLDCYDELGNRYKLPEYVLSAPVNLIEEASESDTAPDTDTNLSPGVEQPIRFRLSNLSHDIKLQVSSTDSVLKLKKRIAEMQVGVEPQRQRWFYAGRLLNDKLRIEDAKIPKNHVVQVIVSLPAQEDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTY3</accession>
    <name>A0ABM0JTY3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101845557</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101845557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101416.1">
        <property type="nucleotide sequence ID" value="XM_005101359.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845557"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005101416.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26713" checksum="3533AA59A75BE8EB" modified="2025-10-08" version="1">MFAVKIDTTQDIATQDQCSIFVRYVDKTGSIQERLVSIVKCEETTGEPFVHIVSEVMQGLNLDPLQCTWNATDSAANIQAHYRGFSTLLSDKAPMQIHVWCHAPVLNPVVSEATSAVANSASLFTLVNEIAVFFLESYQRMNIWSRHSTTMKRLGTTGETRWWSKDDALRKVFDSFNNPLEALFVEVITSLNAILIADNTQAVVVEAKVRGYIDALLKFETVLTAQVVSANIFTHYSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU96</accession>
    <name>A0ABM0JU96_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Signaling mucin MSB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100861463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101628.2">
        <property type="nucleotide sequence ID" value="XM_005101571.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100861463"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="299"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="941"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="759"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="829"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="783"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="840"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005101628.2"/>
        </source>
    </evidence>
    <sequence length="1209" mass="132024" checksum="07574EC455CB0080" modified="2025-10-08" version="1">MSLSGKSNRSKNPSLKRDLLSLGCTSSSPELPAESTDRVNKGQNADPTLENFSKRQTQCTASPSTSGQSLLQSEQTSEIYDFLDSASRGLHSVLTNPESPSELFAATKSPVTQQSEVSKFTTSDTDMAFVTPPSNTSCHVTTSYPTTNHTPASMLLMSLSRETKKGSLSSTPSSKSSSSSSLPACTLSPSAASWPASSLSSPQSLATITTSKSRTRDTDISPLSMGDSITTAAVAAEVATTFSPNSSTATSATAAATKSPENVETASVGDTEESESMQAPLRKRRHPPDEPTKKMIPNLPPCKVCRTKASGFHYGANTCEGCKGFFRRALKTRTIFQCVGVKNCDVIGVNRKLCAYCRYQKCLAVGMSKTAIKIGRYTSETRSRNVLEARLAKQQGLAADESPEAAQEEHAIAPHADDEKNSSNTTKFTKKSKVQKDTIHESFVNGTQDLNMNSSQSDVAHGPSNQKEVFSLLLAPEKDTLSTTQYNSLTLLAPERQDRSCTHEASSKNKKGIALDSQLVDLFKSPCTHHGVCGIAQPIQQNEFTTFPTASQNKWSLEADSSPGTSSFESCPDQDAISLSPIVRQETVPQVSIDLANSVSLDFACLLEDDQTCVTDHVDTSVAQSNVREDSSWCSPAPVYSPCQPSATRRDVASEESSVLSDMSSVLLDQTLYQTPSCSTALTDTMYQSSEHHSEHEENTFTLPISRLTNSNIAIPTVGVCGHEQSNPTVNHCGVSFGGETLVDDLLAASEASYDGDCVQHTSPVASENHISSPASTPSPSPWQTNTVTPPSTWSSTGGARSTKRGEYDMILWSPLSLSADMMQFTPQNSSLPLSPPAQPLWSSSFSSASSPAASVGASPGPSTSSSAVVLAASGEAQIEDQDQERLEIERSLIEILKQPWAFSDERTVKKHIQLLERFQRLNAARSESVVRPICGSDNERLDSIIHDLLVAHNNSMLVSTYFPESFILDRQLSFLKGHQLREQLFGEVKVIPMEDYLYLYRNTGMDIDGRLPFIKAHIMYLESYVQRLVKFAKCIPGFGEMDLEDQILMLKKSRTGISLLGSFRGFNSQLNICVFPNGRCLHRKDMRNFFSPVYADIGFKTADSLKKEVWLPEELVILKALLFTLIDKRQFHNPKAVENLQNLLLTCLKHSLRKSFPDCEPLTLVGQALTKLSLIRPVRNMTCPGKREMFHEFYQRSPLLREIMDPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUK1</accession>
    <name>A0ABM0JUK1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101845781</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101845781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101841.2">
        <property type="nucleotide sequence ID" value="XM_005101784.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845781"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005101841.2"/>
        </source>
    </evidence>
    <sequence length="226" mass="26147" checksum="6C17CEE625B15BC2" modified="2025-10-08" version="1">MDKYDCFLEAGGFIDETSDITEEDDVFKEVDLHDIDTDLPDTLEADCSLNRWVSELSISELQDEALPVVNSEGAQLGLGHTEAPDKDCETTERLGPLEQSLKTLPPRYVRGIRRTVSEPTGSLNKSLSEALKDEIGCMIRFRRFTAGYEEFEEEDKPRKNILTMEDIRRRELVRQRNKKHAKASRERFHQLLEDLKEVGTQIHVFNVVCFWFHLFIPAVEKKNYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUK5</accession>
    <name>A0ABM0JUK5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AP-1 complex-associated regulatory protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101847.1">
        <property type="nucleotide sequence ID" value="XM_005101790.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847120"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031483">
        <property type="entry name" value="AP1AR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34529">
        <property type="entry name" value="AP-1 COMPLEX-ASSOCIATED REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34529:SF1">
        <property type="entry name" value="AP-1 COMPLEX-ASSOCIATED REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15745">
        <property type="entry name" value="AP1AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101847.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29033" checksum="CDDF9D2A05057F30" modified="2025-10-08" version="1">MGNCIHRCFGVIDRRRRYLRSKYAAEKDFSIEFENLMDEEPPRDEMTRLLTDRERQLLSTRQFDVLIHEQRRVDADVETKLAQQEQEIEREEEEYYEAKREAARIAKLNKDKELASKSNPANRGWVNEDEWEVAGAEDDFENFLASVKARSLATISQVKNGSGDAQSTTSSNAHTKDKSLTEGSSLDMEWDHEAGMSPQRKLAARVSEDSWSKPSTTSPIHSSDLEWDPDFVSADDGERIQLISAASKQAGVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUY0</accession>
    <name>A0ABM0JUY0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Centromere/kinetochore protein zw10 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101848830</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZW10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102106.1">
        <property type="nucleotide sequence ID" value="XM_005102049.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848830"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048344">
        <property type="entry name" value="Zw10_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009361">
        <property type="entry name" value="Zw10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20665">
        <property type="entry name" value="Zw10_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06248">
        <property type="entry name" value="Zw10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 N-terminal" evidence="12">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 middle" evidence="13">
        <location>
            <begin position="220"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="14">
        <location>
            <begin position="502"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="15">
        <location>
            <begin position="650"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005102106.1"/>
        </source>
    </evidence>
    <sequence length="800" mass="88322" checksum="1387A89B7BB5FAD9" modified="2025-10-08" version="1">MSSFVAKVLEHAGQMEKKAVHVQLDVLLDKLSGLEVEVHQLVENKYSRFLPTLNAAEDLSHTVHQVHSDLASVESKINSEIKGQLSVSTGEFQSLNQQLTEAKTKLAALNYLVEIQDLLQNFSAAVSTKRYSEAAVAVRQLEVLLQQPLSEHDDQISILKEMRVELTILKETLHRALTDAWTDSVRWNVQGGKLSSSQVGRDVVGKTEEVCLAVSCVGEGAQVLAETVEGLYMTQSLAGKMKTFTEHVQAQMFPYILERSDFVIDLKPSSSVQTLKISVPDKSGSGGNSKNRKPAGNEDEVHYRTVFSNVLALLEHLHKMFLHLGFGWQAAHETSLSSSLSPSVTRDASEMETESSQVATVTGKGTLMSLLGQEVSPWLLDQLCRTVIAKAVPSSAKDLEGFNEVITSTGLLQNKLIELGFIQPDNKTLPDYVQNVNALFASKKCQTLLEEARELMTASLHDSVALPEDKPVGEWPPLLPGGVKKSKRMEAAGGELSENTLRLPKCRISTTVECLVRTAYETLQEATESSPECATQMYYAVRGLFEIFCLVVPKHHSQSLETFPQVAALHHNNCMYVAHHFLTLAHQFAPRLPATIVPTFVDLIHPIRQSGCEAFRRQLSHQRALLLESLDGAEGFANVEEAANREQSERAIKQVLLQLEHLQKVWKPVLPIDVYKKSMGKLTSAVVERITDCVSLLEDIAQEAGQVLLALLSPLEEEAGRFLTSPGEVPAAELLRFVPGWPRLSELKVVLEASLQDISDRWAEGKGPLALAYSPNEVKQMIRALFQNTSRRSAVLASIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV62</accession>
    <name>A0ABM0JV62_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Oocyte zinc finger protein XlCOF6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101845251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102263.1">
        <property type="nucleotide sequence ID" value="XM_005102206.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826650.1">
        <property type="nucleotide sequence ID" value="XM_035970757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845251"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="583"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="612"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005102263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035826650.1"/>
        </source>
    </evidence>
    <sequence length="699" mass="79738" checksum="A2997DE4F229A7A8" modified="2025-10-08" version="1">MTEETMQYQIEVQEGSGNGEVIIIYNCDSEEITPELLANTLTELSKQAATQQTATKLPSENDQSQPQEYILSQDMADTSGQFELSLVDLPSVKVEEPGTQSVTIEGSQFQNEIFLETPLEVKDERLDEAVGLETGLSNSVTEQIQILGGLKPELEPAFEGQATNTLTHFLVGEEAKEQQFVGTDEEANATQSCDNSTNDKRYDVLPSTTSENESAPLEVKEEPVLYSCHHCDYFSRVELEVQRHLKNEHNEEEPFRCSICHKTFKVELSLQIHSLMHGGSADSPTPDIDFGFNVKKIYTCPLCDFEYKSKIKITNHVKKEHKGETVYRCSKCPYACLTSEELKSHETSPKHDDEMKTLCPQCGISCKNIRRHIKIAHNNSRPYLCTDCGFRAKSITNLNAHTVIHSEVKEVKCSLCDYRCHTKNQLDRHMVRHSSVKKFKCSFPDCAFACKTQGSLKRHTQIHTSGIKYACPICDYYARDRADLKKHKISQHPRNVSYDCKECGMSFERVAELKKHSLAIHRSNKICFCAYCDYSCETPQELRDHMQIHYGKYSFICNVCGYTCRLKSLYKRHMARHNKDKKFACPTCNYACAEKADLQKHLTSKHSQEKPYACPHCNYKCKFQARLNNHIAYVHSDLKPYFCKLCPYTGKSAENLRKHLGTHSGLVKTIQCVLCDYATAEKAKLKRHMQVHIKRAVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV94</accession>
    <name>A0ABM0JV94_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101858195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_005102325.1">
        <property type="nucleotide sequence ID" value="XM_005102268.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858195"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="8">
        <location>
            <begin position="64"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005102325.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="42573" checksum="DAA8C60E06B19567" modified="2025-10-08" version="1">MLSSLRIGRSLANSWITGVIQGAHLSTASEASHTVMPYKLHLLENGPNTEVTYTREEALKFYKQMRMIRVMETTAGNLYKSKIIRGFCHLYSGQEAVAVGMEAAITPQDSVITAYRAHGWTYVRGISVHGVLAELTGRKTGCANGKGGSMHMYSPNFFGGNGIVGAQVPLGAGIAFAHKYQEQDNVCIALYGDGAANQGQLYEAFNMAKLWDLPCIFVCENNGFGMGTSAERAAASTTYYKRGDYVPGLWVDGMDVLAVKEATRFAKDFVLKNGPILIEAATYRYHGHSMSDPGTSYRTREEIQEVRQTRDPIGKFKEVIINAGLVTNEEIKKLEDEVKKEVGEAAELAKTDPELPLNELYTHIYVDPPKDMKVRGCDDSIWSDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWJ2</accession>
    <name>A0ABM0JWJ2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103192.2">
        <property type="nucleotide sequence ID" value="XM_005103135.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858648"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005103192.2"/>
        </source>
    </evidence>
    <sequence length="280" mass="30932" checksum="CB446C32E1009EE0" modified="2025-10-08" version="1">MASSMSGPFGNSGPGPLWTGGPAPGQFYNFPGNASIPSNGAAQKTLSPVVMGTSVLAFQFNGGVVIAADMLGSYGSLARFRDCPRLFKVNDSTIIGAAGDYADFQYLTNIIQQHVIDEECLNDGFGYTPKSLHCWLTRVLYNRRSQFNPLWNTYIVVGVEDEKPFLGYVDKIGMAYEAPSLACGFGAYMALPIIRETMEKKPDMNQEEALALIDRCMKLLYYRDARSLNKYQVAVVTKDGVDLRGPIKSQPNWEIAHMIKKKNTGVRMNVVPYDQTVNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXG9</accession>
    <name>A0ABM0JXG9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/glucose cotransporter 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103846.1">
        <property type="nucleotide sequence ID" value="XM_005103789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853571"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF195">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005103846.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22639" checksum="953789F00940C06F" modified="2025-10-08" version="1">MHVWRDPVTGDIPWPGALIGLTTVGIWVWCNDQLMVQRCLSAKSLSHSKAGAVFAASLKVASFFLWIVPGMISRVLFPDEIACADPDTCEEVCENRAGCSNIAYPLLVLRKMPPGLRGVMLAALLAALMSTLTSIFNSASSMFTMDIWRRIRKRAPQGELMLINFLHFAIILSGVSIASTIIISLMTKPRPPQKCFVIDDEGKDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY98</accession>
    <name>A0ABM0JY98_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenosine receptor A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005104391.1">
        <property type="nucleotide sequence ID" value="XM_005104334.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859499"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="60"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005104391.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39142" checksum="8EFD407F5CADA5F0" modified="2025-10-08" version="1">MSFSNLWVNNSTDSRDDSVPITASPSPLHYDIVSDEQWYIVQVVNGVVLCGLVSLFGVVSNIINIVVFAKQGFQDSMNISLMGLSVSDLCSLVAMMWISICVNPLFYLSELPFDPRNIMLPTGAIPRYLFVKISTFITAFITFERCLCIAVPLKVKAIITPVRTKIIIISIYITMSILLIPFCLGNRLEWVFDFTVNATVLKTTYTAERELLEAITYLTQGVFTTTLSFVFVICCTIVLVVKLNSKTKWRQATAVKGDRAAAGVGVKDQKVVKMVTFIAVIFIVCSLPSTLLFFYMLFDSDFRVDGAYPNLYSVIWSSSFLTETVNSSVNIFVYLQMSSKYRAVFLKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZN2</accession>
    <name>A0ABM0JZN2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase RNF166</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101849635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105293.1">
        <property type="nucleotide sequence ID" value="XM_005105236.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849635"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051438">
        <property type="entry name" value="RNF_E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005105293.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24121" checksum="33F5BC3F8CADB8A9" modified="2025-10-08" version="1">METDYPHAAEEEFECAICMDSYSEPHVLHPCRHSFCLACIQRLQAEKTVTKCPKCRSVVQRCDPDAEINERLSCRLLQCGDCKMDVLALYMKQHRMICPSAKTQQELARVSQAGASRGPAVNRSTFSCPYCGEANLLCSQLVDHCNTQHWNSKKKVVCPVCASMPWGVSNMKSSNFLQHLNMRHKFEYETYVDFGQDDDAMLQAAIQASIQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K048</accession>
    <name>A0ABM0K048_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Steroid 17-alpha-hydroxylase/17,20 lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101864320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105622.2">
        <property type="nucleotide sequence ID" value="XM_005105565.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864320"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005105622.2"/>
        </source>
    </evidence>
    <sequence length="445" mass="51376" checksum="EAD13F0059080A0E" modified="2025-10-08" version="1">MSFYSVFGQPICILNSSDIVRRLFGSDEYKLLTSDREPTVVSEFAWYNGKELFFTPYNSQTRQKRTLFHKVMGIYGDGVDKFESIVSKELDRVLEEMDTARVTNQDIPMPQILSRSLKIILYVLVNGDIVPEKLNLDVVDTMERYDNAVNRMFDLQTLTALTFFPPLRKVGKYKKICDDVTESKIKAEKIMFEDLKSTYQAGKVRGIADALFHFQSQPGHEWLDDENIKGFLTTTFFAAHMTSRASLLNIVLILIHHPEVASRIQEEIESVLGDRTPRVEDRLSMHYTEAVVIENIRYVSQAPFTGLRSAREDIHIDGYVIPKGTQFLVNQWFLHRDPNIWDDPWKFKPERFLDESGVILPANHPVRKKFQAFGHGNRMCPGEGFARSRIFLFTVMILQKFDLLPPENEPLPSCDPRDNLKGGVRQAPPFKCRLRNRREAESSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1F6</accession>
    <name>A0ABM0K1F6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101851144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106509.1">
        <property type="nucleotide sequence ID" value="XM_005106452.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851144"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005106509.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="44271" checksum="389F63D77947B6DE" modified="2025-10-08" version="1">MSGVSKPVIEKSPTVIVVEKEVDDKGSGVVSGDHVARDVLVESRKGLSEPLVVDVDKKDTPGLPPIDINELANVLRNPDMPSHKIMKEVADKIVSNCEKSADAKTPADVPGMKNLFDCIMEVSLLQQDSDNSDDDEPEEDHEPIIRHIPCRFCSKVFGSTMTMKTHVLVAHPREDPVVLNVQQLTKNELEATGDKSGPSSRKRSKSSGRSDLDGREKKSRHPSKTDEAKAASVGAENIPVGTRRASLSRSQSKVSPNAVSRQSTEQQDVAKPRSEIPETPAVLSDPDTATEATTAAAAPSVRSSSRTSEASQSAGSGQKRASKREIEEDRNLNTDSSGGSEETVREPSASKRQRLSQGSTAAASTEAPTGSAISSRSRRSLNAEKRAESGDKSTSETPSPAPQGRPRRSSRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1J7</accession>
    <name>A0ABM0K1J7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4 12">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101852041</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4 12"/>
    <dbReference type="RefSeq" id="XP_005106597.1">
        <property type="nucleotide sequence ID" value="XM_005106540.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852041"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="126"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005106597.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="46226" checksum="8A5DBBFBC0C7B079" modified="2025-10-08" version="1">MSFITVAPDSDFPIQNLPYGIFSTPDNSERRPGVAIGEYILDLSVVKHLFDGPALRGRQDVFEQSTLNAFMGLGRAAWSEARETLQRILSDSEPVLRDNADLRSRALVSQKTATMHIPASIGDYTDFYSSKNHAYNVGCMFRDPATALNPNWTCLPVGYHGRSSSVVVSGTPMRRPNGQTRPDDSKPPSVTPCRLFDFELEMAFFVGPATQLGEPIPMERAEDHIFGMVLMNDWSARDIQKWEYVPLGPFTAKNLGTTISPWVVTMDALKPFAIPNMQQDPAPLPYLRHEDPYNFDITLDVSLMADGLSKPAPIAKSNFKYMYWTMKQQLVHHTLTGCNVNPGDLLGSGTISGETSDSYGSMLELCWKGTKVVELGNGVTRKFLQDGDEVIFHGFCEGNGYRVGFGTCTGKVLPAHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1W7</accession>
    <name>A0ABM0K1W7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adhesion G protein-coupled receptor B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106798.2">
        <property type="nucleotide sequence ID" value="XM_005106741.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858437"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046530223" evidence="5">
        <location>
            <begin position="51"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005106798.2"/>
        </source>
    </evidence>
    <sequence length="250" mass="27426" checksum="2F91FD56302A39C8" modified="2025-10-08" version="1">MLSQEGSPVVSSVMNLSHLFSPVMNLSLQRCRVLPSALLCLMLCVCMVSGQQQQQGHWGEWGNVSPCSVTCGEGIQEKVRVWIPGPTEPRRDKPFTSTRTYSCSSQRFPECPTDGQWSVWYYATQCTTMCGGGTRQRERVCVGIANGGKGCEGEKEEVEDCNKEPCPILPPNFDLSQCVQGTNFTCDSGKMCVPIGQRCDRLLHCHDGSDERNCTVTHTWGPGDGASFLQTSFTFVTAAVITVFAVLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K227</accession>
    <name>A0ABM0K227_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101846522</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106927.2">
        <property type="nucleotide sequence ID" value="XM_005106870.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846522"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046254606" evidence="1">
        <location>
            <begin position="20"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106927.2"/>
        </source>
    </evidence>
    <sequence length="443" mass="47918" checksum="261FD8634A2517DD" modified="2025-10-08" version="1">MAFLKATIAFVACLAMAQAQFPVQTSPSCDNQRTIRGVNTMSDSNYCQLFYQCDLANYAKARSCNVGELFDEISQNCKAPQDTVCKSWSCPNSLINFPDLCCDKYWECNNNVFTQKDCGVGQSFDRVRGQCVNGVACQSNELCPSILVNNPQQTSCPLQAAANGNPCSFKFVNIDGDLACAAGTWWNQTACTCSYLPAGQTCSSGDVLRRRTQNKQIDSLCRASFRVDFSGSQLVALSDKDNTPYQVSDGFLLNAVNLFNNEATLSVTPGSSPYIYSYYYVSNELRSPVAMTVVFRPSGVQQGQTFDLISNSFDQNTPVCSTGAVSVKVTYASINNFNFVVSATGSSGTVDTFNFNVNASPNNFLRFVFTFDNVVRAQVFDMGPGGNNAPLSVGSRVSTVGLGRALAFNTCGLTIGGGLDGVIREFNVYEGCGNQFSNLLQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2L2</accession>
    <name>A0ABM0K2L2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107303.1">
        <property type="nucleotide sequence ID" value="XM_005107246.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856127"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="83"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107303.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33999" checksum="6E7F040A15234A53" modified="2025-10-08" version="1">MLRRQARLRREYIYRKTIEERDKNIQEKKEKLRTAIDENKQIPTSLKKTAVGLQKNLNWEDEGADGLTTSVDDEYRWAGVEDPKIMITTARDPSSKLKQFAKEMKLILPNSQRINRGNYRLEQLMDACRANDITDVVVVQEHRGVPDGLTVCHLPYGPTAFFTLSNVVMRHDIPDVGTMSEAYPHLIFRNFTSALGSRVRDILRYLYPVPKEDSRRVMTFGNEDDFISFRHHVYKYEEKELQLKEVGPRFEMKLYKIVRGTLDKLGTADNEWVHRPYMNTARKRKFLSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2U0</accession>
    <name>A0ABM0K2U0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101854748</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005107463.1">
        <property type="nucleotide sequence ID" value="XM_005107406.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854748"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01321">
        <property type="entry name" value="ADGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="196"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005107463.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="60117" checksum="238F694BEB6E4961" modified="2025-10-08" version="1">MEEKKWKICTHIGSGALVVLSVLLCIYTGQVTSNSYLEQRSKIIKDEEKLSLGGELSLSAEEKIVNDIIMKEKRRLIEFSRLNGTEFVPGQSFYISKPMMEKTTVLKIIKQMPKGAALHLHDLSSASLDWLVQNVTYRDHLYFCVDNTTFMIFKFFRNPPHNPDCPWKSVQKARAMAASVKDFDSLLKRNISFLAVDPVSEYKDDYQAWIRFNKYFEQVIDMIYYVPVFRDYVWQTLVEFRRDNVQYFEMRAQLFGLLDLDGNSHDAEFGLNVYKSAIQEFVKRYPDFSGAKIIMSGLRFKSKELILKEVQTAATLHSRYPSIFLGYDLVGEEPNQFSLLHYLDELLYPSRQNPPYYLPYFFHAGETSWQGTAADYNLVDAILLNTTRIGHGYALSKHPSLVKLVREKQIAVEVNPISNQLLGLVKDVRNHPMVGLMADDFPIVISSDDPATWEALPLSHDFYVTFMAMSGEDADLSFLKQLILNSFKYSVMKPAERKRAMDLWKDKWSEFINNVAHMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7I4</accession>
    <name>A0ABM0K7I4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="9">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101855061</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005110595.1">
        <property type="nucleotide sequence ID" value="XM_005110538.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855061"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="13">
        <location>
            <begin position="52"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="12">
        <location>
            <begin position="200"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="14">
        <location>
            <begin position="450"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="551"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="633"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="10">
        <location>
            <begin position="680"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="11">
        <location>
            <begin position="1055"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005110595.1"/>
        </source>
    </evidence>
    <sequence length="1146" mass="129216" checksum="0144CE0D101EC09E" modified="2025-10-08" version="1">MSLRGSFMGMGSSHRPVSFSIWIRINFCCCHAVLVRISEKWRLLPAFLKTKGLVKQHIDSFNYFTNVEIKKIMKANDKILSDADPNFYLKYLNIYVGMPNVQENLGIAQTVSPHECRLRDITYSAPITVDIEFVRGKQTVIRKNVEIGRMPIMLRSSNCILAGKTSAEMAQLNECPMDPGGYFIIRGTEKVILIQEQLSKNRMIVDIDHKGNTECSVTSSTHERKSKTYVYVKKGKFYLKHNIFSDDIPVAIAFKAMGVACDQDIVQFVGNEEEVFDAMSPCIEECHRAQVYTTQQALDYIGAKIRKRAPGSKRSKAEEGRDVLKNVILAHVPVVEWNFHQKAMYLALMVRRIVLTQAGRIKVDDSDYYGNKRLELAGQLLSLLFEDLFKLYNMDLKKVADKNIPKVRAAEFDITKFIRTDPITNGLANAIGTGNWTIKRFKMDRGGVTQVLSRLSYISALGMMTRINSQFEKTRKVSGPRSLQPSQWGLLCPSDTPEGESCGLVKNLALMTHITVDVEEAPIARIAVSLGVEDLQTLNGEEVSNPNYYTVFLNGNIVGITSHYQRLVSTFRKLRRAGYINAFVSIFPNHSHRCVYIASDGGRVCRPYIIVNKGKPLVTSKHIEDLCREFRCFEDFLHEGLVEYLDVNEENDCMVALYEANITRETTHLEIEPFTILGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLLYSLAYPQAPLVKSKTIELIHFDKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKKQTCAVKRYANLTFDRILGPKVDRDTYKPIWKHEPLDMDGIAAPGVRVENRQVMVNKEMPTVTSSSSVQNQMGKQTEYKETPITYKGPEPSYIERVLITSNQEESFLVKMLLRQTRRPEVGDKFSSRHGQKGVCGLIVPQEDMPFTDLGICPDIIMNPHGYPSRMTVGKLIELLGSKAGVLEGKFHYGTAFGGDKVADLSEVLIDHGFNYLGKDYVTSGITGEPLAAYIYFGPIYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDEFEVDVCGQCGLIGYSGWCQYCKSSKDVSTLKMPYACKLLFQELQSMNIVPRLSLKRYNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8E5</accession>
    <name>A0ABM0K8E5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111245.2">
        <property type="nucleotide sequence ID" value="XM_005111188.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857449"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005111245.2"/>
        </source>
    </evidence>
    <sequence length="149" mass="16875" checksum="3D03B9F0AA5316CC" modified="2025-10-08" version="1">MAGVLFEDIFDVKDIDQDGKKFDRVSRLFCESESFKMDLILDVNTLIYPVELGDKFRLVIATTLREDGCPDDGEFNPTSSGPSRADQFEYVMYGKVYRIEGDDGSQDASRLAAYVSFGGLLMRLKGDPNNLHGFELDSRIYLMMKKLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAM9</accession>
    <name>A0ABM0KAM9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Neuroglian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101845381</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005112979.2">
        <property type="nucleotide sequence ID" value="XM_005112922.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845381"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026966">
        <property type="entry name" value="Neurofascin/L1/NrCAM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF158">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13882">
        <property type="entry name" value="Bravo_FIGEY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045199009" evidence="11">
        <location>
            <begin position="22"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="241"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="348"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="611"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005112979.2"/>
        </source>
    </evidence>
    <sequence length="689" mass="77259" checksum="E74E787A81D9A33F" modified="2025-10-08" version="1">MARTSLLSLLLFPLLLAGCSAQEDIRSPPSVLKPDRPDTRYISGGSDFQLECEAEGKPQPTYKWWRDEQPVEITDKVSVDAQTGLLSITNYNSYEHDGEYMCIASNEFKNPSGPPNTASSFSPIIKLLEARMNINSGEDKKLTGTEYSYFMIPCSYEGQAVVADVSINWFQGSRTNQLKEFDNDRIYVDTDGNLHFTYLKSSDRSKPTEKYRCGIGSTQVSMIVLSNGNELAVTEVLNPTPRKPILKYDNSGVRVRRFTTATLECLFGGYDPDPSQPHVPMTEWLGKDYRPIVPGGKYQISEDTRRLTITNIQEEDEGDYYCKGKNSVGETDLNTVTLDVTSEPLWEPEGAPADTTVPEGENAIFNCNARSTIDETPPQSPIWYINSEQTGSHTDPSKYLISADKKRLTVLSVRKATDILCVQCKVVNEEGTTWGDGCLNVILGIDITYQPPEKQEIVYGDTIDLTVRATTDPSIKTLNYEWLFDNETYVTTPPYAIMGQDRYTYINTSLLNNDEYKSVAGLYTCEIAHNFQRKAVNVEVVLVDKPVVVPVTASAGFPMWIIALIVGILFLIIIIIIIICVICRKKQEGDYNVDKKETGAGLDPKKELMEKGFDDYSRPDPADFEYGDKPRRELPYDEDAPLVGEDTKSLGEYSEDEEARFFNEDGSFIGQYHKKDPTRPPPPPNESNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAU3</accession>
    <name>A0ABM0KAU3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 251</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113117.2">
        <property type="nucleotide sequence ID" value="XM_005113060.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859838"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005113117.2"/>
        </source>
    </evidence>
    <sequence length="571" mass="65371" checksum="5C48B9294F7BF990" modified="2025-10-08" version="1">MELSALYTRRLSGSSSRNSFNEDALEQLEFNINDISRASSPASVTSVSARSEGHGSGFRERRHRNSARGDDDYLYRKKFTKIKGELELERIKARQLQHERVEEMRKLREAFENDKKLEMVSLQHRLEEEKKKELVKLKEDLIKQKDFELQQVLMYKESERKQQVSTKPDGQKEKWKEEEEQKVEERGAVEAEEEEEEQAGRNDGDNDVATVSEKTINVKDSVQDRRKSSLDRKTGDHVSSKTVDTGIVKDGGSSYDGGGGGGSEKQPTKEIGDHKVGRNSARSSSHVDKGDNSGRRSRRGSAVSRSTEKSEKHDVGTTTTTTTTESSNLNASDLASDNTTTTKSRQSSKVKDSKSSTAARASARDVKEIEDKDKGDDDRSCVEDVSDHHQTRRSAEKVAQSKADDVEKRQQLSREYEEMVKRLEQEKALLLRQKEEAQRTLDSKCKEHKVREEEFYRLKEGYERELRTVINEHKKVALGNIEKLKLAETALKEATMSDEEIANLSQRHERQRRLSSSSLPALETKKEDREREKTLQKKLGDLTSQIQRLERRIALLRTENDTLRQKQDEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB73</accession>
    <name>A0ABM0KB73_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113403.3">
        <property type="nucleotide sequence ID" value="XM_005113346.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853676"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF42">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005113403.3"/>
        </source>
    </evidence>
    <sequence length="706" mass="78664" checksum="D895566F8C4758F0" modified="2025-10-08" version="1">MDDNVMRKYATPPSEARHYVQYDQGEDRWLCTLLLQQGYRVEYCAASDSFTYAPEGFFEFYNQRRRWVPSTMANVLDLLESWRKVTRKNEDISLLYIAYQTGMMASSILTPGTIFMLIVGAITTAYPEIPLFGSLILNLIPVIIFVALVFMAQSNTQLTFAAIVSIIYSLLMMIVLAGLVKQMADYGFCSVTTIFMVTVIGIFASAALLHPQEFVCILHGPLYFVSVPSMSVLLIIYSLGNLHVVSWGTREAAKPPPPPGQRPPEKKQGTLKKWMTKLSGGIDVEEGVRSLGSIFSCVCCSTTVAAQPVTPANSLAQHIIQEPEAPGASADGNSTQDHAPEPVRRPHWLETVEAVRAPELPEKETAFWKELIGQYLYPMEKDEQHEKKVKEDLLELRNKTCLAFFLINSFFVALVLMLQQVAQETPNLSIEIDCHIDGFEGEAFEPISMAFTLVFGILLALQFLAMLVHRLSTFLHISAATSVKEISGTKVQGDSLSGSASNLSSGLLVDWVKEMQKVKAPEEESEDLLNRDSVQLDIEAGDDEADKTAEREKEKWKRLRSRKTMRKSKKARTVPKTLDDQFTKVFTKFADESISRMHPNSGSIHNGPAGGPKRRAFSDGDNEDPVEAISKVAATNDDFRKTIARKATILKKGVSFSHAGTGVTRRRRTEVDRSKSSPKRVSHVSIRRESSSIEEEDDDKTEDSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUR0</accession>
    <name>A0ABM0ZUR0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101852903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101852903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934856.1">
        <property type="nucleotide sequence ID" value="XM_013079402.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852903"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NR LBD" evidence="9">
        <location>
            <begin position="700"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012934856.1"/>
        </source>
    </evidence>
    <sequence length="908" mass="99909" checksum="14680FE8585075A8" modified="2025-10-08" version="1">MSKDAIKIGRYTYSKRTQDTIELNKIRGGKSLTQVENNRASKFLGGDDSGSGSDGGKGSELSFSARQDHDSPSRVKSILSSGCYEKRNEGQSPLMRRHGTFVDSDFGKETHGKRIKQCFESGVNFEKLLESPKVSACSQDFTSDGRDLSTFLTNGNGHDLLGLLSSKQSEFAQSCRSTEDSDLWDKGCNQHPINLGITPTECHMAAQSRSPLLGEPSRTTAGVTGSPSLDLENIFKTTHSFGPLSSLLQNPGSIKGAEQSVRSPNEPFGNYGCAIDPSTRPSSDNAHFNHPASISGRAQNELESRFNSGDTFKSNELCPNRLDLTSVSSGINLGTKKTARACYTNRMFQENQELVQSNADDLLPLSRVLSESIAGGQDIFSDHAPIDSKLSPATAGFLEDISDCGENDHSVNVLFGQKPMAAKFTLPSFLLQSLSEKGISLVEIGSGVRLLEVLENELKQEAFSGKEFQPLSQLINAYKLSGQCEDVSVEIGPSIYCESKAAGAGKNLTYDGARNFGAQGQIKQDISGFPSVDDFIGSEDFDDDVIKDMGKVQEVIKLYEERKRAFINTGKWALGLDNDHDSGYDESLSSFRRRSSEEAADLSIKDFDSNSILESVLDTSPWQTPGSDCRSPSGKVLNVTACRPPNIAPGSPKLSGKSCAFSMSSLCDKIGTEPLDNIVKGSPPPKIQCPLIDPHFSESELDSIIEHLVNFHEENVIDNNGFNEEQMREKSDSFYHEYCLHEKTFGELKALDRNLYFEIYKSTGLDVDGRGRLIVNFLCGIHNELSAAIKFFKQIPGFRDLSIKDQIVLVKGCSHEFYILGLYRGWNDVTRLMTFIPLGVTMSEQDMRKMFTEKALARHIQMSTALQKLNMTFEQIVVFKAIVAVSPGEYLIHRPKVVMKIRDFINPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVU6</accession>
    <name>A0ABM0ZVU6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fatty acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106011238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935598.2">
        <property type="nucleotide sequence ID" value="XM_013080144.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011238"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012935598.2"/>
        </source>
    </evidence>
    <sequence length="234" mass="25700" checksum="CCAB17E214BEAD40" modified="2025-10-08" version="1">MDGYQDEYMVKILGSKQFFESYYYASIASFADINRDIAGVKELSSFLGNGYCRSEAVMAVFLQKSEDCRRIYTTVVHCKANTDGYKEQGITFPSGQRQKELMQDVYQETGIDPTDISYVEAHGTGTKVGDPQETNTVSEVFCKDRSGQLLIGSTKSCMGHAEAASGLTSLAKIIIAMEERVIPPNLHYNKPNPEIPGLSDGSLQVVTECTKWDGGLIAQNSFGFGGANVHVVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWL1</accession>
    <name>A0ABM0ZWL1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011332</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936008.2">
        <property type="nucleotide sequence ID" value="XM_013080554.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011332"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936008.2"/>
        </source>
    </evidence>
    <sequence length="116" mass="13026" checksum="B30DAF1A2B462223" modified="2025-10-08" version="1">MDSYSLGVVFFACVTRVEPEEGVDYLRRVNTDTAISIPHNVLLNMLLWADPKVRSRTKEILFQLQTHSLTEETSAAVNRPSSIDFHINHVCVVGGGENDDDDDDDDDEENEIDVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX65</accession>
    <name>A0ABM0ZX65_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101856504</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936357.1">
        <property type="nucleotide sequence ID" value="XM_013080903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856504"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6 7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="216"/>
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            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="366"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="409"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="448"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="81"/>
            <end position="93"/>
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    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="101"/>
            <end position="110"/>
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    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="292"/>
            <end position="309"/>
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            <begin position="311"/>
            <end position="320"/>
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    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
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    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="351"/>
            <end position="360"/>
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        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012936357.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="61921" checksum="B342D2C3E17331DC" modified="2025-10-08" version="1">MGSPHNQRTHDVIVSISKEENDVIKTSGLRNDYSGSSKGHRGASYAVTSRPIFRQQGTLLEASVRVECDTHYYGHSCTRFCRPRDDLLGHYQCTSDGQHVCLEGWTGQGCLQAICSSECSPSRGQCVAPNTCVCRHGWYGQSCDRCRTSAGCLHGTCHRPGQCLCHPGWAGPLCDVEELYCLDHKPCRHGGQCHQDSAHNYTCVCPDGYTGTHCEIPVCHKHFCLHGGQCRTAEGTRYCLCPAPYSGPRCQHWSDSSLIDSIAPPPSSPALCQGQNCVGGLSPSDPCYGHVCYNNGTCLVPEGHATPTCWCPFPFKGDHCLQVENPCAKSPCQNNGVCSLDKEGGKFKCVCSHGFSGEFCQESTADDGLCDDILACQNDGRCARSERGQYYCRCPASFSGEFCEMKVETDDPCSQLACLNDGQCVIGRHGQARCACMTGFSGILCQRVEGVCAGRPCQHGGTCVEYDGQVFCACRRGYDGKVCEKRRKRRKTRTKTKTKNKTKTETKTKTETKTKTETTAKATRTKTTLRVTARTINVTERDVAITVCAQWWLLCGLFLTTLCLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXP0</accession>
    <name>A0ABM0ZXP0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein PIF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101847416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936621.1">
        <property type="nucleotide sequence ID" value="XM_013081167.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847416"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012936621.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="40737" checksum="1228943793131B65" modified="2025-10-08" version="1">MQCYFPPAPGRRRRDINDDIDAVTMGVSNTIAVVRQCPFGLFWSQQTRTCEQASIISPAEDECNGSRSRTRSSNNCRGYYACVGRRSVPNCCPMGYAYSKVGCVVCPGCIDSCSSVSAARTYACVFRPVWNDPTSFERYRLSSDGEGSYVAQQCPDNTYFNLASCDCVPKPWRAENETVCGPRLDIPNFAIRRSEFTSENIQLTNLGQAVLDGSTSKLRINLDGNADFANYGGPLVIQFRYKESEEIVSRQALLSSPDCPRAGFLLITVDRESILMEVTTDGGLLTTLKLPTAGFKPDEWKTLRVVDNNDYISLMVSDGEDGYVTRTRAPASPYVQCGLDLGSANFVNGFKGQIEQFTFYQCIPTNIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYD3</accession>
    <name>A0ABM0ZYD3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">adenylate cyclase</fullName>
            <ecNumber evidence="5 17">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 24" type="primary">aplB</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_013081609.2"/>
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        <property type="nucleotide sequence ID" value="XM_013081611.2"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030672">
        <property type="entry name" value="Adcy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009398">
        <property type="entry name" value="Adcy_conserved_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06327">
        <property type="entry name" value="Adcy_cons_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039050">
        <property type="entry name" value="Ade_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 17" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 17 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="922"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="961"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="21">
        <location>
            <begin position="458"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="21">
        <location>
            <begin position="1050"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR039050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_012937063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_012937065.1"/>
        </source>
    </evidence>
    <sequence length="1246" mass="139824" checksum="04306F31ADFE8CA0" modified="2025-10-08" version="1">MAKLPLSLANGGRSIVFDDAHHRRGYPDLLSLTSLQEGQNSNVAESKNDKIQTDQSALNSDKVVFHIVESEQSAPNIVEESSRGDGISSRGSDSSNIRHDLLGGRPEHFINRSSNESTGSSLNNVTFGTSISPPLTPILDPTAHTARLSSISSRVPLYTSLSPGPRRGHVLGARDLGSSRENSGVVSNKNLSLRRVKDSFLDLDLEKLYKRYAVRTKCPMVAAYLGILMVSMIVFLVLSFMLRTLEATVECIGQTVTLIISFIYFTAVFVIVIFDGRRTIILRPTFTSLVIVIGTIVLANLYFGFSNSRTPTSDIPVLFYTVVVSYMVLPLSRKWTLVSGSVVIVFHLLTAGLCSTTHSDLGLQLFCNFLVLSSANIIGLTHKFLSDVAHRRAFLDARNSVDSMIKLEKEKQQQDELLVSCIPSNLVKEIKKDLQENMREPRPTLFHDLYVQRYHGVSILYADIVNFTPLASECTAAELVKMLNELFGRFDQLAKKSSCMRIKILGDCYYCVSGIPTADKKHAHNCVRMGLRMLDAIRDVRENTGVDVDMRIGVHTGSVLCGVLGLRKWQYDVWSDDVTIANNMESGGVPGRVHISKQTLDCLDGEYDVEPGLGGERSTFLADTGVDTYLVVPVERRQTRDRKLGKTRYHDHGMRKSARLTKFLETWGVDKPFSNLKTSSMVSKALSLTSLALIDSNFMMNSSGIDQGLMAADKQQQEEINMRLQDRLNHISNYSFLCKDKSEMHTVFLRFLDPSAEHSYTKQSDDMFPFYVMITFVIFVVIFITQAIMLPRSTMYFVTSTVGILLFTAVTIICFCNQIPFLKRGHKYLRILQRMSTYIEQSYWTRIVLSLGCMGLISLVSTLSLVHCEGPGNSTMSSHLANSTTITPGTSACSYPSYYLVCFLLAFTGYSIFVQISFIIKFIFYCLMFVVVNIVVHVGRGDMFDLYDQNLKSSNDGLNTFMVPLKAKTSVYVAMLLITMHFLDRQMEYANRLGHLFKMQFQRETEQVKMMAAINKIVLENIIPSHVIAYYLRSSRKHEDLYHEAYESVSVMFASIPNFKDFYQQTKSNGEGMECIRVLNEIISDFDLLVIKKFQDVEKIKTIGSTYMAATGLHRGQAGNQDDEAGERTIVTMVEFSLAMMSTLDTVNQHSFNNFSLRIGVNHGPVIAGVIGARKPQYDIWGDTVNVASRMDSSGEPGKIQMREETAAVLVKYGYNLELRGITKVKGKEPMKTFYLLHKKEHNTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYK3</accession>
    <name>A0ABM0ZYK3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101849046</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012937201.1">
        <property type="nucleotide sequence ID" value="XM_013081747.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849046"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14338">
        <property type="entry name" value="UBA_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="14">
        <location>
            <begin position="1483"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="657"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="777"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1106"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1274"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="725"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1106"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1136"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1166"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1302"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1337"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1349"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1379"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1419"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012937201.1"/>
        </source>
    </evidence>
    <sequence length="1532" mass="163838" checksum="21831C0FEDCE6923" modified="2025-10-08" version="1">MATNRSGGKAQAGIGPVRVGYYEMERTIGKGNFAVVKLATHIATKTKVAIKIVDKTQLDEDNLKKIYREIEIMKLLRHPHIIRLYQVMQSERMLYLVTEYASGGEIFDHLVAHGRMNEREARRKFQQIVSAVAYCHSHGIVHRDLKAENLLLDANLNIKIADFGFSNFFSPDSPLKTWCGSPPYAAPELFEGVEYDAPKVDVWSLGVVLYVLVCGALPFDGSTLQSLRNRVLAGKYRVPFYMTRDCEHLISNMLVVDSAQRFTVSDVLSHKWLKATPDEPEPLVDQGVLVEDEGVSLDSELGQQILVHMSGLGLDAEHTAKCVEENGFEHHSAIYHLLADKFRKHPRTIATRPSPAPPLPVVTRTERRSSITTGIVEHVEVPVEVHSSEASLAQPPSSPSTSSSSSSASMLASHLSALAAFRSQYSQLEDSNQSDSDEEPSPEALARYLAMRRHTVGVGDTRHQTSEDMRGKLPPYYPLAPPSLVGAHHLPPPLDLGMPEGVAVLPVSTSNPMFSAYPYVPLAGDPHLLRPPLLYQGSSALGRRASDGGANIHLFSHFQRQFYANSQPGSHEGLSHLSQSLSPTGIPLPTPSLHNSVTVEEAEDGAVELEPDSDAVHEYMQGRGVVKRHTLAMANPINEIPEELQQKLSLHQPLRARRSTGLLSPSERTPHRDSYKDVHALHLPSERYSPVRRASDGSAISGKHQAYLENLYNQTVGQTSSQHGRSASPSTSRHNSHSSLKQLQMECHELQKQSTPVAAERQAELQQQHALHLLQQQSLQSSLCRSPSPPAPGSPGYQRPLSPDGPSTMLYQQLQQLQLHQMSSPAVSPTPGGRHGPSPPLLAAGITSGIPPAVGKGVGSGPPQVGITSGIPPSAVMGKSVGSGPPQTGIFSGLPHVQPLCGGGGSITSGLPLVAAQASGEPSIRYVNTSGLPRGSESPPQGVVVQGYGSSPPQGVVVQGYGSSPSFQNLQMISEDSGDAMENGVEDRLGEDEEMSEEGVRGYGGGHPPLTPTSSSELEQYTMGPHVLRAYAGNPQISITDAQGHVTDVITTDPSDIESPASTLVGSPTSGGGGGGGAPRRSSRCTTQQQALQQLFNPAWVNTNLASIPSGRNQDALTSSSPSAGRPTPTYSTGAVRHHPHQRTNARLRRNTGYHHHHHHHHHHQQQQQQPQSQQHAQSSPSESICDMSSPSPGPPPGAHHHQYYYPGYSTGTDIPNPLGFLSLSAQRAYASGLPPMALPYLAPRATSPTCPTSPDLCSSLSAASNLDRIGASADDSSLVSGQWHRRSAAGGPTMPHSSPCSLVCSPTTSPVPVITPSCPSSPHRERRRGSASPHASPSPSPSPPHIAPSPSICLSTSSSRPSSPVFPSVGPSPTPAFPSVGPSPSSSSPTNGCYSPATSPFPTPANTPRASICAGDSGSHSEMEQSSVGPTVSSWGQELPSVLLEIRAPQCKSVEDVLRAVKAALDSIGPQVDYQCRDTSFRLNGHMDLQMELEVCAHTDQHGPGLQVRKLSGDNLEYAKLCNHLMACVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYU0</accession>
    <name>A0ABM0ZYU0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="13">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21 22 23 24" type="primary">LOC101863978</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21 22" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_012937343.1">
        <property type="nucleotide sequence ID" value="XM_013081889.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937346.1">
        <property type="nucleotide sequence ID" value="XM_013081892.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937349.1">
        <property type="nucleotide sequence ID" value="XM_013081895.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937350.1">
        <property type="nucleotide sequence ID" value="XM_013081896.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825382.1">
        <property type="nucleotide sequence ID" value="XM_035969489.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863978"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1030"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1060"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1099"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1128"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1213"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="313"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="624"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="987"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="1307"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="905"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012937343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_012937346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_012937349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_012937350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035825382.1"/>
        </source>
    </evidence>
    <sequence length="1546" mass="173188" checksum="D7AC46269DC33C53" modified="2025-10-08" version="1">MSEGICRTPLWDTNVTWDTTTPDFTPCFQKSILALIPCAFLFLMAPIRLYLLFRKRNQKIGWNWCNILKVVVTCVLIAFAAFECIFAGIEKGQGDDIAIIDIVSPLIVMFTMMLALFILGIERKKGVRSSGVLVLFWLLFLFCGFLRLISVIRQASREDDVPPSIFIHYPCLLFAFILNLFVDDPPQVGDGSEDQNPSPEKNSSFLSQITFWWFTSLIVQGYRRPLTQDDLWSLNNEDKTEYLAHKFYKKWNLTKEVNPSPVANGDILETSFIYKEGSAILAPYNPHLDESKTPKRSLFSALVRTYFWSFMMAAAFKFIYDCLVFLSPQLLKLLIQFVSSEEYTWRGYFYASLLLFIALVQSILLHQYFHATFLLGMRLRSTIISVIYRKTLRLSNAAKKTSTVGEIVNLMSVDAQRFMDLTTYLHMFWSGPFQISVALYFLWQTLGPSALAGIGVMILLIPINAVIAHLTRKYQIEQMVLKDARIKLMNEVLNGIKVLKLYAWEGSFQDKVLEIRNKELHVLKKAAYLNATSSFFWTCAPILVSLSTFAVYVMSSEDNILDAEKAFVSLALFNILRFPLSMVPNVITNMVQANVSLKRLQAFVDNTELDAECVEKDEFLKPSIKIENASFSWEEGNTTLSNIRLEAEEGSLVAVVGAVGAGKSSLLAAMLGEMDKISGTVSTRGSVSYVAQQAWIQNETLQNNILFNKPLDSSMYEEVVDACALRTDLSILPGGDQTEIGEKGINLSGGQKQRVSLARAVYQDTDVYLMDDPLSAVDSHVGKHLFDKVIGPNGMLKGKTRILVTHGIGFLPQVDKIVVLVNGCVSETGSFSELMSHNGAFADFLRNYLTEELEEGDGGVQDEEGLSRTGSEVMSIRDEILSQLGSQVDDSITLQKQVSIISDRLRTESEMSRGSNTSLNHTTSSPGLKRRNKVSDRMANGEEEKLLKEHEKKDDEKLVKVESVETGRVKMSVFLAYLRAVGPVLTALIIMFYVLYNGASIYSNIWLSQWSNDARNPNITKDEDNRNMRLGVYGALGLVQGIMVYITALMRMLGAVKATGMLHLGLLLNVLASPMSFFDTTPTGRIVNRFSKDVDTLDVIIPMIFGMFLMCFFNTLSTILVISFSTPLFLAVIVPLMVFYYFVQRFYVASSRQLKRLESVSRSPIYSHFGETITGAMTIRAFGQEALFIKESQDKVDLNQISYFPSIVSNRWLAIRLEFVGNFIIFFASLFAVIGRDHLSPGIVGLSITYAMNVTQTLNWMVRMTCELETNIVAVERIKEYTETQTEADWVIEGKRPSAEWPEKGVVKFKDYKVRYREGLDLVLKGIDCEIKSGEKIGIVGRTGAGKSSLTLALFRIIEAAGGSISVDGIDISTIGLHDLRSKLTIIPQDPVLFSGTLRMNLDPFENRTDEDIWSALEHAHLKTFVSGLAEGLLFECSEGGENLSVGQRQLVCLARALLRKTQVLILDEATAAVDLETDDLIQATIRTEFEHCTVLTIAHRLNTIMDYTRIMVLDAGTIHEFDSPQALLQDTSSVFHSMAKDAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A145</accession>
    <name>A0ABM1A145_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calmodulin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938697.1">
        <property type="nucleotide sequence ID" value="XM_013083243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861509"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938697.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16823" checksum="508F219DAFC54817" modified="2025-10-08" version="1">MADQLNEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQVNYDEFVKMMTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4D7</accession>
    <name>A0ABM1A4D7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940614.1">
        <property type="nucleotide sequence ID" value="XM_013085160.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012369"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940614.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="52889" checksum="A06DB9D85EA8FE8D" modified="2025-10-08" version="1">MAPAVVFYLSLHNLHEVDSSKNMDKHTVVSAFLSFPFLYIPPTPLFRQVYLAQHRHRLEQLGDRPYLHHCYPEIPPHRPGTWHVYSWRDIDTVVERLYKVPQRWITHAPRRRATSAGPSGIRPMRSSSNSDVATVTKRSQSATVTNRSQSATAYTKLLPKSTAPTVSASKHRATYKHSTEIVSSTNVRSQNRSFQKNSLHKNESTLQKPATTVSNKRAHSLHPFDFKSRKTTTVNGSLLGLLDETESSQGTHPRSGCFSADVSKESKPHQNTYTTRKNNKETNPPKTITSRSNTELRSKPQQNNTTTSSKGHNFEKIGRGTSTGSGQGYVSHNSDQNRQRSRSAVMKSSKVDFVNSGNVSTISEKTNPPQPRNAASAALLFGRKNNHNQEQRIRRNSDSEIGSKSSPHVVSSIREPRWEFEGGDSDSVVSSVLQLLQTVSSTNGRIRSSSALLNYRERLLQQRQQQQLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4H5</accession>
    <name>A0ABM1A4H5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101852490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940679.1">
        <property type="nucleotide sequence ID" value="XM_013085225.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852490"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045470758" evidence="3">
        <location>
            <begin position="29"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940679.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="28323" checksum="6543475AD6BE4A9D" modified="2025-10-08" version="1">MYGRQSTSMLGSVLYVILLTSCFEVVSADRHCEKVDACSCRYKDSGGLVTMRTLASRDGTPRFLDVLALDNKLYSYNPCVNFDENACHESAICQQGTGHNSTAVSIADQAQVVFGYDGHNVQVSYINTTGVTKIAIVSYVCVEHLTQPRFTAYGKNDSSPGSNYLFQLESMCACENACLPDESEGLSAGSVLLIVFFVLLFVYLVLGTIHGKVSRNATGLEMLPNYEFWTGLPGMIREGIVCVVQCACCRPSKKTYDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5X8</accession>
    <name>A0ABM1A5X8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vesicular glutamate transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941456.1">
        <property type="nucleotide sequence ID" value="XM_013086002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853955"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012941456.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33224" checksum="DE6900A7329C71A2" modified="2025-10-08" version="1">MVDKGGQCTEISREYQKKTMTALVNCVQGDDAPPPPSPILCSYRLVMSIMCSLGLFTCVAQRLSLSVAIVAMVNQTALRQLREEKWNDTHQVSGGCKNCKKVHFEDNVQYTEGEGEFIWSKETQGIILSSFYWGFAVAQLLGAWFSQRYGGRRVWACSMLVCSLLTLLTPIAARIDSYAVVAVRVVLGLFQSVMWPSVCVLFARWVPPLENGRLTSFATTGSLLGAIITLPVVAQLCELPTGWSLAFYITGGCGFLWVVFWGLLVYDSPDVHPRISSAERLYITHSIGKNVTSDLLIKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7C2</accession>
    <name>A0ABM1A7C2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101852261</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942256.2">
        <property type="nucleotide sequence ID" value="XM_013086802.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852261"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1946"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1972"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1561"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1668"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1846"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1668"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1700"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1755"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1765"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1799"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1846"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1895"/>
            <end position="1906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942256.2"/>
        </source>
    </evidence>
    <sequence length="1992" mass="217625" checksum="D2FD9A6B7556E394" modified="2025-10-08" version="1">MRPHHHRYNQSGFDAEDGQMRPKHLRGFVAESRQMRPPHKGFEGEHGRMRPTHHFVPHKGFEAEDGQMRPSHKGFEAEDGQMRPPHLPHRGYEAEDGYPLAGQHEPPQPIEAADGSLWIRIPRAPRSCPLSSPAVRRAMTSASPDVTSPIRQHFQQHLRMSSPAPGNIFPNFRANNNNYTEPESEEETIQVIKLQAPPKRRGKRLMSDSDSQSSASASASSSVSSTPSKDASILIGQSQDPPGTPGKTGRAAFGSPVKNSRLNILGDFSASLEDSNRSPKRLKSDFGPLPSPVRFSRLASEPRGHERSMTAQQDKSSPKEILSKRVGCGSSTAATAAVSATATATLFPGTLHAEGISSRPGFNLPIDSGPRPFQTPPPPPLSNIADRSSELSTRSPRPILTPTRTPSSPRPTLTPTRQPPEPSRYPTTPTQPKSGDPLPININSQLPKTPASAPIFNPHNQRHHLSPPPCGASGDVINSYDVVGKPLNSTSSTRGIRIDEREEGLPDDSSTVETAINDAPLSHNISDTEVRSQNSASEEGTKRKETDVRAVEKPASSIVTSSDATTTNSMTSSDTINNVTSQDTPKVLRIRRKKQEPTVFVFPDVTTPPEQRKDEVDGFETQMDMDVGGDSWVGWTPQFGSHAPSSSFSSSSSSPFHHQGQHLGKNSASLSTPTRGFHGFSGHQQDQQSFHQSFQQSSEQSFPPSVSLSRNTHASQRVPPRNHVTSQEGDLTYDSQRRFIWEGEESTHMLQARNRFNFDLQSDLHKSGKQNVLYSRGEQSGADNRGVLSRPEEVLDTSEPENVVHILEAGSEGGSDDGGVGLHEFLSGERGSIERVGEYSGGVLRHNAAEESYIVRTRADTNVSCVISLSELSGSSMSCEDEGHDDDDDDDYNSDDNDDCVPSFSRSRARRPWDETDGDGGGNPEAGGEKITQKMIVEGQLRAQPEALASDVKTSVENDVSKTCASKRDEVIFVFPDTPGGSGEEGETTSLTERLRVGEKSGTESAQSLSFKKPHSNITSSDEHCQNSQKYPKNESQILTDPNVIFSGQQREVMSPKPRSEHIRGEHVLIDCQNNGGPGFDSGLQPRLVLSNKNSSDHRGAGVSHGYDMCNSSGESTGFVSQRGFEPRTSGQNRNTNAAKYHHNTQIQLMMGGPCGSDDDYNDTDEVDGLGDDEGDNGNTPTSSTSSSSSSSSATSSVAIADIDDSSVVHILDNPARAGTTIKPLKHQPAQRVVQQNDDSIVSIFSESPLADKLTQAQQVQHVQQNEDSVVSIFSQTPLVESKKSPTLATVSVTHPHEIHELPKPDSSDIVSIFTEDSSKVSRQHDVTRQRSDLRVSQISEDSKDISIVKNLSQRLTKSSSSENALRDSVDSENPHHSSSFMASSHGTHKTRAGNKEGRIETETFRRRGSLQPPTPTKPIHRTCSDNTLLLADGAFFKPDQKSCTWPLDRHQRRVGLTNSPSRRKRLEHPTVYSRSLYTDGYRLSPKPSETDMRRNVQGCYFPTTPEDRRVHFYLGDSASPDGGASDRGQFVSPVRGDRFGRGGSVSPLSFGTTASQRFSQSCRSWEMGPSEWEMGPLGRGKGPSEAEKDILAWEKGPSANQAPPTPTRLSPSAFSNKDSLRVTSPRSQLPVQVSVTSKSPTITSLRPATSHSIVKDTLTRIQHTLADTSTEQAPPSPGLTRNKTSAVTSSREDRVMTSPKKKSRLKFHRPWVSPTKDEEHVTSGDQSGCPEAGEFAEKTEDLGENITSDPGQTSRERNRQQKEEDGDENDNTGEGKEEEESEEENLRRQQLYHHAQRSRSLIETSPSKSGPHRRTAPRSISEPRWNKRHSDGDWALRFLEQTTIPELTSSSTPSPLRSRESLMTPSVSGSCRSEEFRSASRRGGLRQRDVVLTPSDQGQPGTTAGRSPVASAPRQTPDSGSVRREEPTCECARIERQILTSAVDMFRWVVIVIVIIESVVVIVIVIVRVMVIVIVIVIVSVSVSVIGIVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A812</accession>
    <name>A0ABM1A812_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM184A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942605.1">
        <property type="nucleotide sequence ID" value="XM_013087151.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858379"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039478">
        <property type="entry name" value="FAM184A/B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15665">
        <property type="entry name" value="FAM184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein FAM184A/B N-terminal" evidence="4">
        <location>
            <begin position="48"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="56"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012942605.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="72220" checksum="9817E163FB25A569" modified="2025-10-08" version="1">MASGAKMSYNHFQSGKFGGLPQASQKDAEVTQDMHLKMSKKIAQLTKVIYALNTKNDENETVLQALREQHEEEIQQILADTKQKVAVYKDRLDEESDHQATIEALQTRIAEHQSQQAAIEEQFSQYKINIREKQEKEREDYAAKLFDMSHEVLKAKKDFEDHIDKFNSWKERINAQHSTAVAELGSKHQREMEDLRSFQRNQDDTWLNQCAQIEEKFKDQIESLKSQIEAMEAEKVSLNEEYTAKLEKAKAFYEKELEALRLNQTQEHSVEVEGLKKEIDRLKGDFGANDKELRVQIDRLVRQLADTEDSLEASRKEQQILQAELAGRNSSSSELAKQLEDLREQLASQSSKLHSTETELAGSKQHVADLADELSKKSTLLGELEAHNMQKESIISSLRDELEKLRQQLTRVDAERTSLLSQQQSSSSEQKSQLQSLRQALEDMTVEKETQKQRFEKQIKSLQDELEKTEKSLKEEMALKLSEMEKSHVEARESDRKCAAEVLTATKQELKENHEKEMSQAKSDYEALQQEFEQVKADLKSRLAAAEEELRRMEQMIKQSEEGLGSASGQLKSMKEAAEHLRTELEKTRSELKFSKTTAASLQVGLVSFVWFHHLYHCLSHPASGYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8X8</accession>
    <name>A0ABM1A8X8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101852433</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101852433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943088.1">
        <property type="nucleotide sequence ID" value="XM_013087634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852433"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012943088.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11897" checksum="58524E1465D11D91" modified="2025-10-08" version="1">MFLDDDRSPEEVASALEAGAEPLPEDAVVYAYEVETTGEVRVVVKFTSVTGVDYPSNPSDNKQLFTVEDLTSDDDIPSGDIPVIILVEESDTVLAKVCTGGLSLLCLVAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9M9</accession>
    <name>A0ABM1A9M9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Death-associated protein kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943476.1">
        <property type="nucleotide sequence ID" value="XM_013088022.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857828"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943476.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22878" checksum="328797D6F694D95F" modified="2025-10-08" version="1">MSCFFSLCPRKRATVDDCINHAWIRPKKQNEELQRKSAVINIDNFKAFMARKRWKQSMRVVSLCNRLSRSMLLRKSTDTLGSRNTLDEERREKLPSITERNAAPDSKEPKVQNGPLDKIDEPVVKKLPNDVKDLGEEQKELLNVKGNNNILSQLGSQTRTTDKLSFSGMTCKSPGAVACASARPFATLKSPKLVTIDDDVIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9U3</accession>
    <name>A0ABM1A9U3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013152</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943583.1">
        <property type="nucleotide sequence ID" value="XM_013088129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013152"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943583.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="59192" checksum="02B85641B9AC5833" modified="2025-10-08" version="1">MWRRSLQDVKVRRGADVGSDHHLVTARIKLKLKKTFSREATKTRLNVHKLSDGNVRSAFRLELKNRFQTLQDQEETTPNTDEVNTQWKHHIVEAYTESSKTCLGVKKKNASKEWIQQGTWNTIEDRREIKKRQLAAKSIRLQEKYAEDYKEACQKVKRLVRKDKREAMEKLATEAEEAAAKGEQGNVYKITRIICGKFHGGMSGPIKDKADKLLTIEKEQEARWTEHFREVLNKPQSEDTPDIQEATLDLDISSDPPQKHEIIKAVKSLKSRKSPGMDNRNAELFKVDPELTATILQPLFKTIWEGEQIPGDRCTGVIFKVPKKGALRDCNNWRGITLLSVPSKTLAKIIINHMSDAVDSCLRKEQNASKEWIQQGTWNTIEERREIKKRQLAAKSIRLQEKYAEDYKEACQKVKRLVRKDKREATEKLATEAEEAAAKGEQGNVYKITRIICGKHHSGMSGKLLIIEKEQEARWTEHFRAVLNQPPPEDTPDIQEATLDLDISSDPPQKHEIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABW2</accession>
    <name>A0ABM1ABW2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC1 domain family member 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944744.1">
        <property type="nucleotide sequence ID" value="XM_013089290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855450"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20788">
        <property type="entry name" value="TBC1D23_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039755">
        <property type="entry name" value="TBC1D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045799">
        <property type="entry name" value="TBC1D23_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297:SF5">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19430">
        <property type="entry name" value="TBC1D23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TBC1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944744.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23251" checksum="4EF6D8BCF1B043A7" modified="2025-10-08" version="1">MKYFSKDLLGKLSGVVKTKSAEMKEKLSNYIKNEGLSDRHVSSTERGGKRYRNMANVFTIGDDDEGEEGSGVESEEEEEQKEVVSLETWRQKTDVVYSCRCKEIRSNGHSFPSYLLVTSSHLYVLREIAARRGLAHIQARRALGSVVKITSKKRQPELITFKYGTHEEDGFHVTDMHRFYIPTASDATRVIKQQIMRVLDALDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC14</accession>
    <name>A0ABM1AC14_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysozyme g</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944836.1">
        <property type="nucleotide sequence ID" value="XM_013089382.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013490"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01021">
        <property type="entry name" value="GEWL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002152">
        <property type="entry name" value="Glyco_hydro_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31698">
        <property type="entry name" value="LYSOZYME G FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31698:SF8">
        <property type="entry name" value="LYSOZYME G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00749">
        <property type="entry name" value="LYSOZYMEG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045589143" evidence="1">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944836.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26717" checksum="8C5469DB02F5B353" modified="2025-10-08" version="1">MITLLLLVSLAVTTNTDAFFFRSWTRSPPVRSPITRSPFWWTWAPPTFATSRPPFWNLVSSLRTCHGNVMDLSPTGQKSGGVSASNSDAQADITYLNKYKTCFQKVAVSQCIQASLIAALASRESRGGSLLKDGYGDHKKAWGILQCDIKKSGLNCKSCGWDSCCHVEMMVRDILVPNINSVKRKFPSWTDAQALQGGVAAYNFNLDNVRTWSKLDVGTTHDDYSNDVIARAQYLHGQGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACA1</accession>
    <name>A0ABM1ACA1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calponin homology domain-containing protein DDB_G0272472</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944961.1">
        <property type="nucleotide sequence ID" value="XM_013089507.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850609"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944961.1"/>
        </source>
    </evidence>
    <sequence length="821" mass="94043" checksum="249D9967D064F934" modified="2025-10-08" version="1">MASMGSLVKGEQVPVNFNLPQSTAIPEIEKAKKTVGKHQNRIIENLNVVKLRVADELKELEEYYAKQDLKEATAKVQEEKDVTEDLEFEVTGKTDRWKDDLIFLGPRFQTIAPKYERAINRLDDETLRPQFKQLLNDFRRMFLHSKFIRENDECPRFLDDIKLWLGGLSAEEEEEIFTDKRLKRIYLGAVEKLKAVKTLQKYVETIGGRYSEVSMLAESQLMMEYRKLMAEQQAFAGPLSSSQYDPSLIDRIDVEELLEQAKDLEESLKDADGRITTLTKEIDTTVQKIDDTTAQIAAADGLMERMKTEVPYSETMKQNLKDFQQKLLGEIVKTVDTLHTTLDPVLSDEAADLHTIEGGKKEMDNISTIVAKLDTKLNKAGLAALKPLEAVHLSEISNTCFDRDLLCLVSVVVKAMDSYRDSLGQFHSRAESRIKDEMHALKKNMVRDSDCSKLAHDVGRLHKHMDSASAPHSSVLTALKLSEKMVQEFGRQVTCTRLRNLERLTLEYNLADHSMELVLRAAPLINRAMHKLAAAEEKKRQLEEKKAAAIEKKAREKERIAAEKERQAVEKEKLSAQKKKEEAEERKRIHKEKQAEEEREMAEGKKGGEKENERRRKQREEQKKRRSEDYEGATKDNEARGERKYSTLGEKREARRESKDGYGRARQHSDVSGLSRDRLGSRAKGTVDNDNTTKQKSTRTKSLSPDKDAPRKKLFLRNIMEDDPLVLPYRRHSDWATRTLPPLKQKTPLKFRFYSQGVPVFEDEKGRFVEASGEPLKKLEQEPAVYGSRLLFRPVLVARRVALQVAEKNDSSATAGSRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACK2</accession>
    <name>A0ABM1ACK2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101861168</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945113.1">
        <property type="nucleotide sequence ID" value="XM_013089659.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861168"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945113.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23280" checksum="629394C42FD420DE" modified="2025-10-08" version="1">MEVVIGPYIMEETASCSSGYNSDTEPQEAEHQESEITQEDDDVDADPQQVDLDIFTYDQWQLSLCQNDRQQQVQRSHHYLREPVHFPPTFHQLLPRTSYERQRSEVGVIDRDKKGPNTLLSLKSQVPKPGDPAGRRRSSLLSESRHTGGIRRESKAKQHIYQMLAGAVAAPLTSLSDEEEEEEEDREESLAEHTSLSSPPTLPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD19</accession>
    <name>A0ABM1AD19_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC106013648</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106013648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the YAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945378.2">
        <property type="nucleotide sequence ID" value="XM_013089924.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013648"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053819">
        <property type="entry name" value="TEADIR3_omega_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15238">
        <property type="entry name" value="TEADIR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="309"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="574"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="776"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="860"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012945378.2"/>
        </source>
    </evidence>
    <sequence length="998" mass="109695" checksum="EFA528DAEE466DD4" modified="2025-10-08" version="1">MSQDRTGPIVHVRENSDTELEALFNIAMNPQLASETNKSVPLRMRNLPASFFRPPEPPKQNMQQQMGVNASKDGHSPADAPVFHGAVNSSVNIAHMRAHSSPASLQQNLSAAPPPPPTSHVRQHSYDLLDEQPLPAGWDMAKTPQGQRYYLNHVLQITTWNDPRKTHTPGTTAPSGSSSSNNNINNDNGKPGDNKDSRGGDITYRDSRSIPKDAEPSSKSHHTATTTAAKIHDLEIDENSAKALIVEGNSDVMTKHSDRLWQNPVMYAHDQRGVDKHFSAEHQAVMRYCKKTSAVSTAGFTQAQTVTAEQNPPSLVANGRKITRQSSPDLEDASTGRKGDHVGLKSSVKDQQKSALTAVGQTTTTATTTRTTTTTMATHKFPTGATVRRNRKRVMPKQGEESRLLVEISNPKATDPCNCLSQWQSEDSSVDEANGSDKDDWENDLSVYGKADADASRRWVVGTSNVAFMHHHHHHHHPDVDQKSLSDRELIRIARKGMKNDSRLLQPGMYYKASNNRTGQLGESRRGLGDFHRGLYREHTRMGSFLDKRLIEQGAESGLDPDSIRIGRSTSVPHLELGEDGAGEGEEGEMNEALGSTGRGNLKLSRQNTLTDPGRRARYRPLSDPPDVKFGGAVQKHAKIHRSQLAAGVTSHHQSPGAHNSEQQAAEAVALLRQSYPLEEWKKMVDSGECGFIVRSFPAEREVQEKPTAGSEIDVGGDRKDGKKAEREEINISTEISAERVLKKKRGANDGLRLEIRNFKKAQGDDNIIILSSENTKNVPGNDIVSSDATGPISDQTEEDSPEDSDDIENIRSTYSIPLVSLYMESPTKVDTYVNSTKFKPSKKLENNGLRARMSSLLLEQDQHSSSKVGSQHSSSKIGGQIADSPLTQRDNKNQLPISVGSNNNYNHPDGVSLEGVNPEKNQSLLESPKPQGVNNGVLGDVSVKRELQIYAHVRKGLCYEKQGELIGQPLDRVKTTIGRDFLVLDGKKPYQNNYRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADD3</accession>
    <name>A0ABM1ADD3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenosine receptor A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101855389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945533.1">
        <property type="nucleotide sequence ID" value="XM_013090079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855389"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="65"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012945533.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40842" checksum="AEE70FC76CA38D27" modified="2025-10-08" version="1">MPISNLLLWVTNSTYSRNESVNLAITTSSLELHYVKIVSDEQWYIVQVVNLVVISGLLSLFGVASNIINIVVFAKQGFQDSMNISLMGLAVSDLCSLLTMIWISICMNPLFYLSDLRFDPRDIMYLTGSAPHYLFVKIATFITAFITFERCLCIAVPLKVKTIITPERTKTIIISIYVAMVVLLIPFCLGNRLEWVFDFTRNTTVLKTTYTAEREMLEAITYLTQGVFATTFSFIFVFCCTVVLVVKLNSKTKWRQATAAKSDLAAEGVGVKDRKVVKMVTLIAAIFIVCAVPPPLLFFYMLFDQDFRIDGVYRNLYLAVWSSSFLTETVNSSVNIFVYLKMSSKYRAVFMKTFLNNQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AED4</accession>
    <name>A0ABM1AED4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101862991</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101862991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946073.1">
        <property type="nucleotide sequence ID" value="XM_013090619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862991"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012946073.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23944" checksum="29C0430BF291D552" modified="2025-10-08" version="1">MTKVELEILQGTLRTLRAQSCKALSQMKFLFPCNRPPEGIDLLLSVLQLSLKLMSYLCPSSQNSFESCLKAIVQGMFKPCYEMFRTVAIGDLGQGRNATLDPRLLNILIQDIREDVSDYKNHFESTFQRYFSISKMAASTFYQLLMNDVHALTETDPRHKPLVEIDLRMLALGYRLKQLDSDWKMYITPQQQTWRAAFQGSLTQWTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AER0</accession>
    <name>A0ABM1AER0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101851174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946272.1">
        <property type="nucleotide sequence ID" value="XM_013090818.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851174"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF4">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="185"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="256"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="318"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="6">
        <location>
            <begin position="384"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="709"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012946272.1"/>
        </source>
    </evidence>
    <sequence length="837" mass="90726" checksum="0C7240B14561111C" modified="2025-10-08" version="1">MLLGSPAHHSHEGLEDGASVCDVMSGAAQGSLLRPVTERNGHVSRRIFLVLVTVCVVWLCGEVGGQEMRCSKEGERVEVALVDSDPCYSCFCRKGRVECDRTQCADLEGCHAILFSRPAGLCCDVCKGCTVNGTIIPSGTTWPNELDPCVIRTCQAGVITTSREQCHPPCAHPVSVPGQCCPVCAGCHYDGQDRMSGETFPLKTDPTVECVCKIGTITCSRRACPVLNCPRDSVYHRKGERCPRCKGSRVIFDIRGSCYFSKRVYQHGDVILLDSCTSCVCEHGALSCEREQCADVTCPEQERELVAGQCCSTCRVYRGCHTEGGVVQHGESWNSDRCTRCTCEAGHVKCVARLCAAREPQCPRGFVRKEVDGQCCPQCVRGESRCSVRGVEGRRVTTFDGLRYSVSGQCTHELVRSCMDKSLSIRIRYSGSHSRRRRRRQEYKPRETTGSGDVTGPGENVTTSSKTIGSDSVSGDQESSSGHLSVARGSGITSVKLHNTAHYPTASNRRTEGSNKVIELVSVQLGSTRIKLYRTFKVRINSTVHYTSSWKSGQFSVRVKPPRVFLRSSLGVRLAWNMRDNLSIRLDARRAGVGELCGMCGDFNGHSRDDVKDKRGRRLDSARHMAQAWMRGRRCKRQHGTLARAATGSEVDLGSVPKNRVSSGVPGITRSKSSSDSDRRKTGSDSGTSGSSGIKVPVVTNVSAHASLDTGSGSSTDTGSGDVTTPVTIASSSERSSKSLSGSSALPAPPRRPSTSSTSRIRPVDTSEGVGLCQPNSLHWVKVKDDCQKIRNIRLQNCKQVVEVDGFMRLCVEALCSCEGRVPCEVSILQTLSTACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF06</accession>
    <name>A0ABM1AF06_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106013988</name>
        <name evidence="9" type="synonym">inx</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946416.1">
        <property type="nucleotide sequence ID" value="XM_013090962.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013988"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012946416.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15690" checksum="1F48847DCBFD4BED" modified="2025-10-08" version="1">NIKIRYTLQCTLPINIFNEKIFAFLWIWFWAVCAITTVNFLTWVYKWVFNANYVDINKFLTARGELITDYDRMMAVKFGTQYLRRDGTFVLHVVLKNSNSVVMGDLISELWKMYKSKPLPPKAWAGQGDVMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFL7</accession>
    <name>A0ABM1AFL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">H2.0-like homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106014165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the H2.0 homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946696.1">
        <property type="nucleotide sequence ID" value="XM_013091242.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014165"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052497">
        <property type="entry name" value="H2.0_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46808">
        <property type="entry name" value="H2.0-LIKE HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46808:SF1">
        <property type="entry name" value="H2.0-LIKE HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="302"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="304"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012946696.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="44758" checksum="47075D1582DE6A43" modified="2025-10-08" version="1">MMNVYGCVPTPYLPGPASLSYWAQAAALAGLPVSELPPASLTLGLKKSQFPVSLSDVIQKSRSGGGGGGGSLRTADDITASFRVTSHTLVTSRPSPPSSGELASRLSSSAQAQLHSHLQQQQQQRHQQQQLQSHLHRMSHRTYSGTPPPVGNGLAPLQALCDADVSAFTAKTGAGSVGEEKRGGLKFGMSRILSEDFGKTKPEKENNFQLSSVPEACRSLPLCPCNSPSCTAYARPSSPYHRGPSPYSRGSSPFQRTPIPSLSAVHALQPPTYPLSSSVDALPGPYSILSTDATSSAATPKRKRSWSRAVFSNLQRKGLEKRFEVQKYVTKPDRRQLAAMLGLTDAQVKVWFQNRRMKWRHAQQQGEKDKQLQQTGQTPRPPEDKGREENREVAGAAAVNLDAAHSTLGVDVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFY1</accession>
    <name>A0ABM1AFY1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Membrane progestin receptor alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12" type="primary">LOC101862706</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091864.1">
        <property type="nucleotide sequence ID" value="XM_005091807.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091865.1">
        <property type="nucleotide sequence ID" value="XM_005091808.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012946880.1">
        <property type="nucleotide sequence ID" value="XM_013091426.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829806.1">
        <property type="nucleotide sequence ID" value="XM_035973913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862706"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF92">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021924" evidence="7">
        <location>
            <begin position="25"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005091864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005091865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012946880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035829806.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40190" checksum="67EC344ACA48377E" modified="2025-10-08" version="1">MSDMESKSQQLWLMLQSCLSWVKAELLCGGGEGQGLLTVEQVPDVMKEPFILTGYRRLYKPWGYYLMSFARLHNETLNVWTHAAGLLILLSQLIFLLRDFDVTEDKVSWPNLVFGICCLLNMILSATAHLCHSKSPWHHYLFFLLDYSGVTIYGFGTGIGSMYVCSSKAFHDSWAFCYLTLLVLSTCFAFFACCVTKILLPNHAARKPLMVAGVSTQGLVTALPTFARYAECFTSPSCSLADMNHISLVFLMLVVCAVTFVAHAPERWKPGCCDVFGHSHQIFHVAAVVTMLFQFRALHIDTNVLKIAHELDPSPRLICQAFVCVILMEALTLIASARFILCKRVASSDDLACRKQKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPI6</accession>
    <name>A0ABM1VPI6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101857470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824328.1">
        <property type="nucleotide sequence ID" value="XM_035968435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857470"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF106">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045431452" evidence="6">
        <location>
            <begin position="20"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="222"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="290"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="357"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="424"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="491"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="558"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="625"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="692"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035824328.1"/>
        </source>
    </evidence>
    <sequence length="797" mass="85882" checksum="573D5612701524E0" modified="2025-10-08" version="1">MASMLLYVVLIIIVGTALSKERCDVQYGFTRDPSRCDTYRLCSNGLVVSSARCQDGFLFDNSTKRCKEPGQVQCDTGSSSRRDDSKVGQPCDVSYGFTRDPSRCDAFLLCSNGVVVRTAKCQEGNWFDNSTKMCKYSYQVQCDIGSTRQNDSTVGQPCDVYSGKTQDPSRCDTFLLCSRGLVVSSTKCQEGFLFDNSTKVCRPRDQVQCDIGSSRTNGSTVGEPCAVSYGFTSDPTRCDMYQLCSEGVVVGSARCQDGFLFDNSTKRCKEPGQVQCDTGSSSGKTGSTVGQPCDVISGYTSDPSRCDTFLLCSGGLVVSSTKCRYEFFFDNSTKVCRPPNQVRCHNGSTGTSGSKVGETCDVFSGYTQDPSRCDTFLLCSRGQVVSSTKCGEGFLFDNSTKACRPRDQVQCDIGSSTTIGSKVGETCDVFSGYTQDPSRCDTYLLCSRGLVVSSTKCGDGFLFDNSTKACRPRDQVRCDIGSSTTIGSKVGETCDVFSGYTQEPSRCDTFLLCSRGLVVSSTKCGDGFLFDNSTKACRPRDQVRCDIGSSTTSGSKVGETCDVFSGYTQDPSRCDTYLLCSRGLVVSSTKCGDGFLFDNSTKACRPRDQVRCDIGSSTTIGSKVGETCDVFSGYTQDPSRCDTFLLCSRGQVVSSTKCGDGFLFDNSTKACRPRDQVRCDIGSSKTIGSKVGETCDVFSGYTQDPSRCDTFLLCSRGLVVSSTKCGDGFLFDNSTKACRPRDQVQCDIGSSRTNPTVGGLCDVATGFTRDSSRCDAFLLCANGVVVRTAMSGRVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ34</accession>
    <name>A0ABM1VQ34_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824526.1">
        <property type="nucleotide sequence ID" value="XM_035968633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861193"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824526.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="53655" checksum="8E4DEA8AFF6062D2" modified="2025-10-08" version="1">MTRTLNLYSLTRAAGLLALLLISLLDVCSTSVAYRKSKSLRTKRFLMPPVTTEEGEKFPSGRFDMGDNSGGDGVGITKGDNSSGDGVGITKGDNNPDLVPHFQTKYDVVSVEPQGKFAGLEQTANTPLSLWDWNPGPALPQVDNPALHSFPPELQTGRLVRQGQMYPSLNNPIPGGGMFPFNTPTAAGGVGQTPPSSQGLPPQGVQGPQGIQFQPSMIGPNQAGGLPMIGSFQQQQQQQQQRWPTIGSNQAGGLPMIGSFQQQRWPTIGSSQAGGLPMIGSFQQQRWPTIDSSQSGRPSPFLQQLNQYSGRFPVPANDGGGYAPQNLAYNNNNNYDNSNYDNNNNNNNNDYNNNNNNNQYGNIPQTSTGLLGPQRLNSQKGDTYNVMVGVNLMTFPERQRAAGGPGSPVQGQVQVQGQMLPLPLGSGGVQQQATSGGGSELGSGGGTASDMNAWCGLVCPRGHSLAYSPRKACYICVCGDLSGSLTSGPGSMGLHQNNPAMPMVNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR35</accession>
    <name>A0ABM1VR35_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101847947</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101847947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824877.1">
        <property type="nucleotide sequence ID" value="XM_035968984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847947"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035824877.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25999" checksum="D32263CC5F544AF0" modified="2025-10-08" version="1">MSLAVGTWVRPDSRFKSLPKLMDSASPARPPRIFGRVMTPIFPRSADMAVPKSSTLEFTRSRTEPRIEILNVDGLEMYDPDLLDGDDLDCESDAISDEGETPRSRAEKAAEFEVAHNWMLKEETERNARKFDRTKRKLTICLPDDDPLEGINNRLEEVQSMVKPKAELSGFIEDMDPEQRERIYRITNMDFHTVSKERRKNWKKSDFIKHAFRMVRMMTLATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR46</accession>
    <name>A0ABM1VR46_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118477470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118477470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824888.1">
        <property type="nucleotide sequence ID" value="XM_035968995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477470"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="81"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824888.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17360" checksum="9270A591F42A0A43" modified="2025-10-08" version="1">MTNEILFSFPFYSKWKVWVGVVVNSSLSGPLTWEDGSPVWYPTADLRSRADPDSDQCLTMETLSPYRWGLVNCSQRFPYLCSVDEGVCVYEVTPTSSLVGYNTAKFFEQDREGCRKLCDENKDFTCRSFEYSKWHFCQLSEVNRYQFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR68</accession>
    <name>A0ABM1VR68_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Erbin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118477477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824910.1">
        <property type="nucleotide sequence ID" value="XM_035969017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477477"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824910.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41147" checksum="29D6463CA73B8E78" modified="2025-10-08" version="1">MFASGINAWTYSTLYSNQLHLPETDNILPDGQGEFNRQELELLMKDLLHIYTAQCHLFAEQYGGVMFQTTPENGTAAVTSAIQHGDKHVLRLGKKIETKSTVLLKKTFRNNVFCKAHQWCLSSTNVAVEERFTYQKEFFSPYEESIKVLFNELPQLPDVPKDFFQQLPNLQYLRLQHCEMLSVLPAGISDCTNLRMVSFKDSGIQNLPPDLFRMPALQRLHCRRLPVRSLPTNVMEFSPLTELVLSGLLLTALPAQLSQLANLQLLDLNFNPLQTLPMELAKLSKLKTLLLSGIPWVVNAGSKVEIPLEQFEEFLKENPPLKYYIGREVSRTLLEPSRIREKNLGSPMCKLCTLTLCGHLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VV45</accession>
    <name>A0ABM1VV45_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoprotein hormone alpha subunit isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GPHA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826287.1">
        <property type="nucleotide sequence ID" value="XM_035970394.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100533432"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052680">
        <property type="entry name" value="Glyco_Hormone_Alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31129">
        <property type="entry name" value="GLYCOPROTEIN HORMONE ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31129:SF2">
        <property type="entry name" value="GLYCOPROTEIN HORMONE ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glycoprotein hormone subunit beta" evidence="4">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035826287.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18435" checksum="B2065B062EECDA36" modified="2025-10-08" version="1">MARALCFAVPHGPATRSEVLAMTSSWPAPTGHNSASDISSPRSSFGNCRRYLLALSIVVLFCPSVTPQRHSWEAPGCHLVGHTRTVSIPGCVSFEVTTNACRGFCVSYAIPSPSHTLAVNRNFVITSRAECCGIVDTHDVKVWVACRSGFQQKTFKSARSCQCSICRRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVJ5</accession>
    <name>A0ABM1VVJ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat-containing protein 64</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826437.1">
        <property type="nucleotide sequence ID" value="XM_035970544.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012172"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826437.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15769" checksum="23453EC1C3AC76AF" modified="2025-10-08" version="1">MSTIAENGGGEDPHRPYTVGTFQVKLDKFEDLIRDITYRDAEATPEERRQWITENLRFDQFCEKIRELFGSDIKNQDLKSIYRKISTNPDAKVDWSEVINEMQQLDNFMIMSFLFVSFQPFTVFTVFLALVQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWN1</accession>
    <name>A0ABM1VWN1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NXPE family member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826823.1">
        <property type="nucleotide sequence ID" value="XM_035970930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478042"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NXPE C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826823.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23602" checksum="A5D23A7C0120A849" modified="2025-10-08" version="1">MIGDSNLRHLVEMMAYHQLCTPTAQLIGMQNWHSPQLCINHQYKYAVRWRTHAMPFHTNADHWAPRVNQQSVGTSLDEIPATGEYIILIHMYLHFSTHHYSVYHERIKDFAKAVGRLVVRNPTVKILVRGPHVTYKGWAPVLGGDLQAPLYLRILKDEFKDLYDKVYFFDFWDYTTAAESVGFHPIGHITSEKLKFIFSTVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VY38</accession>
    <name>A0ABM1VY38_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-B-cell leukemia transcription factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101848905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/PBX homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827331.1">
        <property type="nucleotide sequence ID" value="XM_035971438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848905"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005542">
        <property type="entry name" value="PBX_PBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03792">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51978">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBC" evidence="9">
        <location>
            <begin position="38"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="231"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035827331.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="40931" checksum="FD0C01479BF07AED" modified="2025-10-08" version="1">MDDQQRLMHPSQGQVSMAGVMPQQGYDGSLTQGDPGDQRKQEIGDVLQQIMTITDQSLDEAQARKHTLNCHRMKPALFNVLCEIKEKTVLSIRNTQEEEPPDPQLMRLDNMLIAEGVAGPEKGGGSSAAASATAAASGGQPDSAIEHSDYRAKLAQIRQIYHTELEKYEQACNEFTTHVVNLLREQSRTRPIQPKEIERMVGIIRKKFSAIEMQLKQSTCEAVMILRSRFLDARRKRRNFTKSATEILTEYFYSHLSNPYPSEEVKEELARKCGISVSQVSNWFGNKRIRYKKNIGKAQEEANLYAAKAASAASSQMVNNTPSSPTGSSNYSLPSSQSQLGGQGAMYMNINGGESYPGGENSWGLEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYC7</accession>
    <name>A0ABM1VYC7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple epidermal growth factor-like domains protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC118478274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827420.1">
        <property type="nucleotide sequence ID" value="XM_035971527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478274"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391">
        <property type="entry name" value="INACTIVE TYROSINE-PROTEIN KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391:SF18">
        <property type="entry name" value="PROTEIN KINASE RECEPTOR TIE-1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0420">Kringle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kringle" evidence="4">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035827420.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48480" checksum="90300CB258B68C4A" modified="2025-10-08" version="1">MSYWSFRKMLGTTTTAAWIYVCAFYFLTVGFTMGVDAVPAMHLTFYRDSLRGILQRCPDGYFGFKCKFECHCEGNRVCDKVTGSCPRGCKDGFWGPGCQLENGCFYNGQKRNYMGTLGHTKTMFTCQRWESQTPHAHSYTARHFPDRRFPRNYCRTTKDSDRPWCYTTDQRTRWEYCSIISCGCPSGRFGHNCMKECHCLDSSERCDSILGRCRSGCAKGWTGSDCQTPVPCFANRYGWECGQICQCQNPKHCDRFLGPMEQCRCRNGFFNPPFCEPVTAPRFVFFENQKVNPGQPSLFNCTVAAFPTPYESEIRLLGPEGKRISLKSSETLDKYLYTRTNIFHVNYVMNGERYTCSVQATAGSNQLTMMAEVYELPRLSTPPKLARHGRGAHNMTLVWPAWDDTAGDTGEGPILWYSVHVRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W051</accession>
    <name>A0ABM1W051_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase MORC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101855367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828044.1">
        <property type="nucleotide sequence ID" value="XM_035972151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855367"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16931">
        <property type="entry name" value="HATPase_MORC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056360">
        <property type="entry name" value="Chromo_MORC2_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041006">
        <property type="entry name" value="Morc_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337:SF3">
        <property type="entry name" value="MORC FAMILY CW-TYPE ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23327">
        <property type="entry name" value="Chromo_MORC2_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17942">
        <property type="entry name" value="Morc6_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="9">
        <location>
            <begin position="496"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="935"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="935"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="962"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035828044.1"/>
        </source>
    </evidence>
    <sequence length="1103" mass="123604" checksum="5CC76543560DBEF9" modified="2025-10-08" version="1">MDFTGLNRAQLSFDYLHTNSTTHEFLFGALAELLDNARDASATKMNIFTISDNSLRGGYILCFLDDGEGMDPAETASIVTFGKSTKKSDDLHQIGMYGNGLKSGSMRIGNDLMLFTKRGDAKSCLFLSRTFHEEENIDEVIVPIPSFDIGSRKPLATDAKGKAKNDVEMEIILKYSPFKTLDHFFEQFDRIEGQSGTLVMVYNLKLLDSGDTELDVTSDRSDILLANPSSHDFDSDEGLMPERKSFRAYAAILYMDPRMRVYIQNKKVRTKRLACTLYKSKMYKYSSNRFKTRAENEAKRAIDEALAAENKAREAESKAKNLEIKTGSSTQKEHRATLRKAQNYAAECRGNAQIKRQMAERKTKSLKDPKTLNLIFGLNIENRNHSGVFVYNCSRLIKMYEKVGPQNEGGVCCSGVVGIVDVPYLVLEPTHNKQDFADAKEYRHLMRAMGEHMIQYWKDVGIAQQGITKFWENFGYISSEWKDRPSDDVKYARKRAMQLSVTLQCDVCLKWRMIPFNSNNIGKEFPDHWVCTMNPDQQHNKCSSTEQKLNIPEGVLKKEIKSQEQKKRDLEEEILRKTEMLEKLQKMKVVQSSKDLSALSRKEERPEGRASLGRKAKARSPSPAPRSPSPEPPPPKSSRSSGSQGNNNNSSSSSGSSSSKAVSAKRSRRSPTPPPPPTRPASRPPASSKPAKVAAKSSSQVTVKSKRKSPSPPPPRRAPPAKSKSKKKPPVSSEEEEEEEEEEEEEEEEEEEEEEEEEEAPKSRRGRSQNSSQHVETSKEAKRSRTKEQVIEYPEIPVKKQRVSHFNTPASDSGAEKKKAAAAVPTNTEVVVSDSGDEGKASSRSSSSRMRGKGGNLRSEASADENEAQPTETEDSKPVKREDVLGCRVEVLINNKWXSASIVEVKAAEGKWKVKFDHHPKDKYDRWFDKSDPDIKLLDGNKSSESKTPRPASPSSQEGTEEAPTSSTATPALTTGVTEDIANGYRTCLRYFLPPQWIMDKDAITAMSLQELSDFPLDDFFDHYERGLRRLVSNFQTEASLRKQECEEAKAKLVSVRKLIAKLLKSTNEDGRNQDFDIDPEESGDQVDELLAACVRQATAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0U5</accession>
    <name>A0ABM1W0U5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101845356</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101845356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828288.1">
        <property type="nucleotide sequence ID" value="XM_035972395.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845356"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF516">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035828288.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="28544" checksum="A1B3CBBD95CD3D8D" modified="2025-10-08" version="1">MGRRRKHLDIQGGSKIYDDVSVTLSSQKPGKENPAFEMDTVDRLQAAALSRTEPYSSGFSQSLNGSRVNKAFIPDDISSSSSNQVSRRVEGGRIATISGPGLDEANLPPVTFDHELDHVSTQGSEEKVGLKRTMTLLNCSAILISVTGHVAIFVSPANVAKNAGSVGACLVVFLVVALNCAYVKYVQRVQTLLSASKIIALGIVIGAGIYQLASGDTDAINRMNNMFEGTSSDPGEVALALFYTVFSYGGWQIVTSLLEEVKNPGRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W149</accession>
    <name>A0ABM1W149_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Complexin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101850213</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Positively regulates a late step in synaptic vesicle exocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complexin/synaphin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089026.1">
        <property type="nucleotide sequence ID" value="XM_005088969.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828392.1">
        <property type="nucleotide sequence ID" value="XM_035972499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850213"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22740">
        <property type="entry name" value="Complexin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.580">
        <property type="entry name" value="Single Helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008849">
        <property type="entry name" value="Synaphin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705:SF4">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05835">
        <property type="entry name" value="Synaphin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035828392.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17156" checksum="DAAD79A62073209D" modified="2025-10-08" version="1">MAAFIAKQVVGDKLSSVKGAMNKEDEGDKETDDAEAAEIEEARREMEEKRKEKHRKMEEERETMRQGIRDKYGLKKKEEIVEEEVDPMSEGRVGRKKKTPAELAAEANKEDSDDEEFAKFPPNLSELSTKVSELPAKLAQGVGEVTEKCVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3N3</accession>
    <name>A0ABM1W3N3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TBC domain-containing protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101855159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829276.1">
        <property type="nucleotide sequence ID" value="XM_035973383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855159"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF168">
        <property type="entry name" value="TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="472"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="794"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829276.1"/>
        </source>
    </evidence>
    <sequence length="897" mass="101580" checksum="6221B8440CD842EB" modified="2025-10-08" version="1">MPALGTAGFGIRTFYAATHPNDKCGANGLPLTPNSVKILGRFQFLKTLSHPRLCQYLDISKTKHECMLVVSEHHSSSLKELIKKEGSIGESEIVRVGYQLLEGLCYLHNNGVVHRNLSVEHVLLDVEKNVKLSEHGLYYMTDYGADVSFPIGLPRYMAPEVLCSGPVRVDEETGHCVQPLSGPKSDVWAFGLILLQLVLGKEIWARLGIKETLHKIVEMIKSDMSPIDIFQQDATVASKLQGTSRELRDVLRLCLTVSAAKRAKSSELKQHPLFRDERMKAVPHKEEVRMCTTELRCKDLELPTYEETIENEFSDDHLSRRSMSEVFYLWRLAGGDLEAVLRKAGLAKTRRPVHLLPCYGIVDGEVFGQDRDFAELLDFTVVPLSQEQLRYRLRDVPATAYYPLLEEESKVVETQSLPTSPSSGELTSSASLPLVIREKDVEYQFHRIILYERLLAAYPFKRPCIWREARVDIPPLVRANVWAAILEVEGDVEGMYDSIDKETPTTTDRQIEVDIPRCHQYHELLSSPSAHAKFKRVLKAWVLSNQQYVYWQGLDSLCAPFLALSFNNEALAFACLSAFIPKYLHKFFLRDNSAVIQEYLAVFSHLIAFHDPELSNHLDGIGFIPDLYAIPWFLTMYAHVFPLHKIVHLWDTLLLGNSSFPLCIGVSILQQLRDRLLSFGFNECILLFSDMPEIDIERCVQDSIKIFCSTPKSATYRQHARPNKKKTSEDRPNLSYYSRDYHDQPQSELSMEPIPIDELKGEKCCRISAEDLIELGELAGAAYSRSPTKKRQTSKPMILIVDVRSPEDFRRGTLQDSINIPFQTAFSPEGDLNPCSAVQTLNSRRNQVIIVVGNRGRNAANFANELVRLGYSRVCVLHKGLDVFRTTGLITVPPADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3Y1</accession>
    <name>A0ABM1W3Y1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101863074</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101863074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829374.1">
        <property type="nucleotide sequence ID" value="XM_035973481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863074"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="785"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="840"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="843"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1043"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829374.1"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120116" checksum="462D58E275943DEE" modified="2025-10-08" version="1">MSVPSSPTRSTQDPGFSSSKSPDAREKKPIPLDSKLENRLTMKDLERLRSSFMVEGDGYDNKLSLTKEQFCEALSLLLKKGTREEYAELFDKIDVTREGTVDWDRLASHMLLEFYEKDDRVKSTQVPQWKDIKMLPSPHKEIVQRVAFLKNTNRYIAISKEGCVSMWGSDLKLQRHLKTGTDTCKMRDLWVTDFVLLQNVNKIALAFTSKEIAIYDLSSKLEFNCQYKVQGLNFTPLCLDYWSNPNNANDAILVWGDVGGFVNILFFNSANIALFERPPAPAGEKQEPCLNVQLKDIVSGKYKNATYAKYEAHNEKNRGEWVRQVIYSQYLECFISCATTTSNAVVIGWMEKHQNINLTKKLSLSIIYSQYLECFISCATTTSNAVVIGWMEKHQNINLTKGKQTVKKGIQRKNEFNVSQGVNAFGYNENLNLIATAGVNNHVCLWNPYVVNKPNGVLRGHMASVIQVQFIAARSQLISFSKDKVLRIWDVQLQVCIQRLAGMFPKGPEVTSTLFFDDGRDRSGQERNRLFITFNYQLTAMDMKTEVKDRIMSHEKPVVATLYNSVYNQIVSVCQAGTITMWLVDTGQKVKQFNNTHGNSEVTCLTQDQSETRLYTGSTDGTVKPTFHGPEKSILGGLSTKLPDIHGERTGSSSSKSGSIRGRRSANRISQSQGSGEEANEFGWAVARLIFLENRRGNSASGGANLVSCGGNGWVRFWNASRSTLLAEFVAHRNAGSIIMTSDPNNHYLVTADVDGVVKVWEIQHYALSHVDEPITTPPVLKSQFQPHQDQINSLDMCERNERLLIVSASSDCSLALWDIFGNRIGVFGQEEHWKIEPLLPQDELEDEEEEKGEEEDHEVMSIEAEEDSHWEPDEMAVVEPSHYRINTWDRTVLGKDYQELRVQKRERRQPGTIPDLPYLHWERTGAPPAGPYSALDTKELKDVQALVKPDAEKYFNERPGSSEFSSSKLPALAETLMTAFDEKSLFPGYILDFERKMKNYHSMMLNQNQAKGKNLRGSLQNIGMQMGQPKAPMSPRKSIAAKGPLGLKLRGPGTRKSSIATTVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W498</accession>
    <name>A0ABM1W498_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Snaclec coagulation factor IX/factor X-binding protein subunit A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118479032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829491.1">
        <property type="nucleotide sequence ID" value="XM_035973598.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118479032"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045470002" evidence="1">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="38"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829491.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20395" checksum="92B5B0ED05C95977" modified="2025-10-08" version="1">MRPPVTWTSVCGLLSLLLSVAQLVASAQCPSGWTHYSGRNSCFKIFSTEKSFSRAAVFCRQLKGGPQNNTNGHLAHIFDKQTDDFLKQLLQESGLDAVWIGLEDRAKDGLYIWEDGKRLKNGDYTGWVSGKNHQSDGYESGVTLTEDGWTELYSPYRQAFLCQVPAGKVFSHIDTPVLEGKGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4P3</accession>
    <name>A0ABM1W4P3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance-associated protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101855167</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035829636.1">
        <property type="nucleotide sequence ID" value="XM_035973743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855167"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="919"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="971"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1072"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1153"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="280"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="579"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="973"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1246"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="831"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035829636.1"/>
        </source>
    </evidence>
    <sequence length="1485" mass="167124" checksum="C43539D8E1702D62" modified="2025-10-08" version="1">LPWVPHVFLWLVAPLYLAFLMTSEKRSAGQHSVMMTRKMTYTLALILLTAVQIAMSGYQEEGEEGEMTRRVTCLYGRMTSLLLTLALLRVESSRCCTHSFPLFFFWSLLLLSDCLSFYTDLTFEPDLGDVTTLSLTVLALGGSVAQAVLFSLPDTSGQAGPTHPDDASSVLGKLLVSWATGRVWDGCRQGLTEDDVPGMAAQDRCRALTPHFERAWHREQERLKRHSRGVTEKTVDERKTSGRKEDGDQGVSLLRVLIRQFGLEFFTYQLIKLGFELTHFVQPVLVGYLLDYFQNRDSQPAWSGHAIVVAIFLTSLTTGLGHQTVSTSVDRVAMKVRTSLKLAIYKKTLSARNEERAKVTTGEIVSLLGSECDKMVNCCKSFFILLSVPAQLTVGLFMLYQQLNVGAVVALALILLLVPFNAWISTNLKRLETEQNDVKDERVKMMNEVLNGIKVLKLYAWEKSFLKRIMDIRDREVNLLKKMGVLYGGVDFIFRSVSIMVCIASFATFTFMGGVLDPATAFVANAVLVTMSRSFSQLYLVVPQFFRAADALTRLNSFLNLEDIPDDVVKRTDQSKAAVQITDGSFAWATSDEKNCLKNIDLTIPRGRLVAVVGMVGAGKSALLSAILGEMEKVTGEVKVQGRVAYVPQEAWILNTTLRENILFGSPMNRARYDKVLDACTLREDLKLLSAGDETLIGEKGINLSGGQKQRVSLGRALYADTDLYLLDDPLSAVDAHVGKSIFNSVISRQGALRDKTRVMVTHGVHWLPFVDTVVVMKDGQVSETGTYKQLLDHHGAFAQFVREVNRHDPDPDPELEPLKQKVFNRLTSLDEGTEIIESDEEDDYGDDDNSVSEDDRGNGEIISPGGKTLSVDEGKEEEEEEEEEEERSRDERDRSEDEEETETGALSWSVYGQYLSSFGYWYFLVGFLIFCLLIYFREEKEWSLARWSDDVELSNRSQAHTPNYEHTVRYHFLSFALCGCGEMVTAFVFVCLMQFRTYEAGKFHHNKLLVNILRSPMSFFDTTPNGRIINRFSKDIQSVDNLDMLNYIKFSLNAALFFFMILFHIPRIIPFMIPVVILYLALQHVYLANSRQLRRFISRSRSPIYVHLTETANGSESVRAYKAQVRFTKKMEQKVESFMRNQMTEHWFSTWYSFRIHLLGCLVTLISGLLLLADVTISPARVGRILSFSKNFLHCLSLTIRHASYMETELVSLERVIEYSNTPTEAAWDTEPGLVSSSWPEDGHVVLENYQTRYRPGLKLVLRGVSCDIRSGEKIGIVGRTGAGKSSLTMALFRLIEAASGRICLSGQHIASLGLHDVRGKLTILPQDPVIFGGTLRMNLDPLGEKSWGELWEALEHSHLKTFVQALPDKLDHECGEGGQNLSMGQRQLVCLARALLRQSKVLILDEATAGVDMETDGLIQKTIRREFRACTVLTIAHRLNTVLDYDRIMVLDSGHIKEMDSPRNLLADKNSVFYSMARDAKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA91</accession>
    <name>A0ABM0JA91_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol N-acetylglucosaminyltransferase subunit P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101853894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PIGP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089042.1">
        <property type="nucleotide sequence ID" value="XM_005088985.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853894"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016542">
        <property type="entry name" value="PIG-P_GPI19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008765">
        <property type="entry name" value="PIG-P_GPI19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="9">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005089042.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14900" checksum="65005E5A4845D2A3" modified="2025-10-08" version="1">MAQEHSPSPTPERAVYGFVFYLASFVGFVVYIVWAYVPDAWLHSVGLTYWPQKYWAVAVPTYFCVAVILAFIAYTGLIFLKTAPITDGRTITDSKAIIYDSHVELQPNALPPLRDLDISTVNRILYSTDATCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCK9</accession>
    <name>A0ABM0JCK9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-CoA acetyltransferase, cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090597.1">
        <property type="nucleotide sequence ID" value="XM_005090540.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860546"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="270"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005090597.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="40881" checksum="2ADF95CA69055A7F" modified="2025-10-08" version="1">MTEVVIVSAARTPVGSFNGALSSFTADDLGGVAIKEALSRAGVAGEEVSEVILGQVLSAAQGQNPARQASVKAGIPFSVPAHGVNMLCGSGLRAVVLGAQAVRLGDAKIVVAGGQESMSKAPHCVHIRGGTKFGDATMTDSMMCDGLTDAFNKYHMGITAENVAKQWNIPRDEQDRFAVTSQQRCENAQKNGRFDAEIVPVVVQSRAGPSEVKKDEFPRAGCTIEGLQKLRPAFVKDGTGTVTAGNASGINDGAAAVVITSKTEAESRGLKPLARIVSWAQAGVDPSIMGTGPIPATRKALENAGWQVSDVDLFELNEAFAAQSLAVVKDLGCDPEKVNVYGGAIAIGHPIGASGARILTTLLYALRSQNKRKGVAALCVGGGMGIAVCVENLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD17</accession>
    <name>A0ABM0JD17_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosinase-like protein tyr-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101845062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090894.2">
        <property type="nucleotide sequence ID" value="XM_005090837.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845062"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005090894.2"/>
        </source>
    </evidence>
    <sequence length="332" mass="35308" checksum="D27DC252E2B7C282" modified="2025-10-08" version="1">MSTPEEYFAEGTQAYFYVQSYAPRPDGVRGPINTREKLQRYDPQLYNMIREVFPCHNTYLKRCESNRAEENAQVLQMDCNLGGGGGGGGGGGGGGGGGGGGGGGGEGGGACEDGNARCSSWAQRGECNKNPDYMLVNCKKSCNRCPRTTTTAAPATTTTTTTSTTPTNPTGCTDNSEHCEAWAQTGECDINPDYMHVNCTKSCNLCHITTTTTSSSSSSSSSTATPTTTAAPPSSTTTARSTAAPPTTTTTTTLPPDCEDNHRHCRSWAQRGECRSNPEYMNTSCRRSCNRCGTDNNCSDLSPHCGYWAGSGECRRNPTYMNENCRVSCELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDP4</accession>
    <name>A0ABM0JDP4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091289.1">
        <property type="nucleotide sequence ID" value="XM_005091232.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852667"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005091289.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27976" checksum="77A7EA0EDA17B89B" modified="2025-10-08" version="1">MSDSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGKDIVVLGVEKKAVAKLQEDRTVRKIALLDDHVALAFAGLTADARILINRARIECQSHKLTVEDPVTVEYITQYIAQLKQIYTQSNGRRPFGLSALIMGFDLDGTPRLYQTDPSGTYHEWKANTIGRSAKTVREFLEKHYTEELAASEAECIKLTLKGLLEVVQSGGKNMEVAVMRRGKPLQMMGLDEIEKYIAEIEKEREEEAEKKKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDS8</accession>
    <name>A0ABM0JDS8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">COUP transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101850389</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091372.2">
        <property type="nucleotide sequence ID" value="XM_005091315.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850389"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06958">
        <property type="entry name" value="NR_DBD_COUP_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06948">
        <property type="entry name" value="NR_LBD_COUP-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01282">
        <property type="entry name" value="COUPTNFACTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="104"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="206"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005091372.2"/>
        </source>
    </evidence>
    <sequence length="442" mass="48914" checksum="ADD8AAE3E8571E1D" modified="2025-10-08" version="1">MAVSAVRSLDMPPTQPTPVIPWREPSDDLGGHPPPPPLGNPGGLPPVPPPPSQQPSHTTTVAPTGHNTLVPVDPVPPGSPPGNHQNNGGTPNSNMSENNNNKQQIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRGSRNCPIDQHHRNQCQYCRLKKCLKSGMRREAVQRGRIPPTQHPFHGQMAFHNGDPLNGHTYLSSFISMLLRAEPYPTSRFGNCMQQPNIMGIENICELAARLLFSAVEWARNIPFFPELQVTDQVALLRLGWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMAAERVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIALFSSDACGLSDMNHIESIQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSAQVIEQLFFVRLVGKTPIETLIRDMLLSGGSFSWPYMAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE65</accession>
    <name>A0ABM0JE65_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101850625</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091642.2">
        <property type="nucleotide sequence ID" value="XM_005091585.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850625"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH OST-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="428"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    <sequence length="519" mass="57957" checksum="4737052E2BC5A646" modified="2025-10-08" version="1">MMIPEEVKKNVRAVLLSRTGGVPLNQFLYDYQKLLCEPLMFKPLGFSSLHKFMEAIPDVARIVNPNDSGAKLFGVGEPDSYMPLSARKAQGTLPRNYHQNLKKREESESNDVDDNTDFTLEPDLRGFYSVCLPTELSPSADDKAVIREVFEQVGEVKLIHITSNWVFVRYASLAEAKSCVDTFKDEYDVRLAQNKKKAESSKEKPEKNGKPWVSSKGGNKKGPRRNRGEFTEAEDESDYEPVKVDRVKNGRRAKENGKAGLAKKNAGDVSMVNGHKSVDRREQNHDSAAVVSGSSEEHLDLFVGRIEHEEEFRKMVERYDPVSVCVRCYGRKIFAFVTVKNRAEGDRMIQEQNGKMQTNVELYVGYNKTRDDNASVKSDGAESTILSKKAKVNKAAKGARTECGFSNMPALEPVGSYSGRAMEFDLDCCVFVGFFPPNTLVSSLRELFETYGIVDICMVNNGSGPGCTKAYVYLETVYDVVKAVKELNGNNGLGLPIKVDVPFENTVVRRILEKVLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABM0JFB6_APLCA</name>
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        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        </source>
    </evidence>
    <sequence length="3318" mass="366871" checksum="0B6B919169DBD778" modified="2025-10-08" version="1">MDSKQNPTSLSASKSTTNGQAEDATSIATSDRLADDIIINSAALENVDVLSKSKPDSAVIDDSDDKKLDPDPIHSMDVQNSKNDAEKVNTEEEKAVVDDVNSALCNNSSVVNNSRSNEEKNVEQTSAVKMSDTDSDVSLTRRGEEQMEGLKIDNVNAVSESTFVKDVHDGKESVKKDVEKESSSSGCFSMSSESKSEDADVNTKQGNENSKTPVDSVLSTEGDRLNCSEMKNSESSQNCNGEVTGPASKDSASNENCNNEDSKLTGDGAQSIVQTLDSSELPSKDNTKSHHVKPEATSEKSSSSSAVTQSEATGSADSGLPDAQMSSSQEATQAVISSDQGTSEPTAQPPVHGQVNQPQNCSASTSSDQTTVGKPVKYRCPKCARVMKDKRLLANHSCEKEGSPEEEKVKITIGLDKEKKSFVCKECDFTNSGHGFEEHLMCHLMIRPYQCLYCKECFINRKEISRHVLKFHNGAKMSCALRALRRAKSLIKEVSLAGTLTFSAKVAGKVPLEKDPERKKKTSEGSTVVNNDNAPAQPVIAAVTSESKAPEKGSAKSTPVPADAAKGEKKVDKTVSDKTITQEETKDESQEVPVCDTKEDVNSAQNFSKLREVLTSNETVTKEDAGPTSDGETQRCAEEEVEVDKEQTNSSSDSGLKIIASYSLQDTQIDGQPLESSDENNAAENVAPNFIMMPPPVTEKETEVLSFLGPEKPMYKNSVAESSPPSSSSSSSSSSTPMLPPPPLQAAPSHSAPNNSSVLPPPPQLVVSAAPRPQQKNPNFFICGFNCLFSSLSTAEFREHTTNFHSSETFFPCYYCGHRSPNENDLVRHISNHTHTHNKSSPLYVCGNEGCRFGTNMVPDYINHVKSSHPHITEPLCNACGDVFPDVSMLQSHVEENVIHIVNCPHCSSKATDRRAILNHISTVHPGKPKMVSVAKQLICHDRKINNYEEMKQLREMLPPTLTPAPALASSSPGGSSVLDHILGKQHEDSTEQRGKSVGNTLAEVLAAGTSPRGSPSPSARMLSPSSRRREATPDSGRSPNSESSGFGSHRVKEEVEEDVDELGESSGVDDSSSGYTIDENGIRRRIYVPMSERQAENYRCRYCTFIARDLKRMNCHERSHGMPPTKKERFKCMFCPQGFDSEMKFRLHITCHPGLIKFLLYRCKKCEFDSNQKHTIVKHITCNRDRKHRGSGPVEDQYTVVSRSLESRVLQCEQCDYMTRHKIHMAIHYQREHGVLRDKGEFTIEGLTPTDTPLSSYDTPPSHSSSRSTPSPKGIQQSPDASSSHDAFDFTRPTSAAKRSRDRMHESSAPAALTVNQITERNENFTRLVSQQTALQPGLVLENQVRKFKCPICKYLLPKAADLKNHVKRHSEIGQITLVMFRCKYCSCMSTARELLYEHLGEKHPGKPIALVKKIVAIDTTEVDKSFAETSVEESFEQLEENLHKELATALKNNSPSPDQAKTETSGDFLSASTASSSSSSTAYEQLFVIPEGGDVFSVPLQCPKCSYNTHKKADIIEHVNSLHSEVKVISNDEDVEKLAKATTEDILNAAGKGSTEKAVSKPGFLSQEEVLIVPDDQIFKEPALCSRCDFATLLRRDMVMHLQQFHPEISVMGRNSYPVQVSAMGSKVGPMEESCVVGSGSLDAKIRCLYENYGTQMKCLICGTERPKKFFIHVHILRHLNIYLWKCAFCAHRGLQKYKMVDHIKKIHPGKPMSVRYLRVNVEAKVAQFLAQFNIIQNRKASLDEGLEVPFSANDTSHDHDDNKGTCQQSCSGGHHQSPGHSGPSSASSNYNHTLGSEELDSKIGCLYDFSDGVFYKCLVCPNQFQRKFAVHRHIIISHLKVALLTCSYCGMEGVEKHQMVDHILACHKGQPVNIKTNEVDLAQNVSKFLAKVAAGEDNADVNNTGDGLGSSKSSDSSKDYYNRMYRPFAFSKKPRSFGLSGSSSTKLKSPTFRFGNYKSSTPSTTKTTTPGKKNNLVDPDVIMLGRDALDRELSCLYQTRNTGQLRCLVCRWEFPRKYPLHRHIMLKHLKMNLVGCPYCPFEGVEKYNVSTHIKEEHKDKPINIKFTQPDVGGRVREFVDDMANVGGLSQNLIQKPESSNSGSRSSSPVVSLKRERDGDDDENTNGTNDSETRGGPAPPSLVVAMFGKKKNKVPPSPLTTSEDFVVKTEIEDEEFEEGAALDTHDDNDVLHSASKHKHGSGEDGEEENDDYNEEDDPGADRSNYDPEEDEEEEPDSSQFSTLRRPLVQSYAPGSYRSPAGGKPKALDVITKIKVLKSKDGPITKFYCEKCKFTSLHRSNVVRHIYKIHEKYQTHTCPICNYQTLSLMLMRKHTDREHPGQEYKEDAFTLNPPRTKPRTLMGPLSFQKRRQNLLHKKLSTVTPPRTTPQGPKQYACAYCHYETDTQDDILKHTKENHSQGDDSYSTARASSSQQNESDEDDQTSACWDGSKKAVKRKLQDGSDTTFKRKRRFVFEKGDELIQCGHCDARETSMGRMQDHMDWDHQGLPFNCKRIPAWRFVCKSCAVKTMATSKMKYHLNRHVNYRPYTCTNCGAFFPSPDQCRRHSRSQGHEEQYMYVRNPKKEIRVEELLEETRQLAIKVQEEAIKDPEFDIAFTDKFISQFQENRGNLKRSAPTGSNSRSAKKARAAADGDDSGDWVERKQTGKSAQTVGVEMCVTIKCYNCEFSAGTVSEVYNHHKEVHHDERFLWTELERGFTCDKTGEALPDCDSSVPNASTDVGYTTRMTLGAGNNTMRFKCKTCDFSSCVIQAMKSHLKSHQPKGFICPYCSRSFSGKEKLMRHQYCLHKGMALWVIHLRMSGTVGSILTSKKGGGPSLSSSVSRPESSPKSETAGPSVSPKPTDEDTASSGKLTRRSSQSALNYLCSECDYETESLYHFRLHLSQQHQGFKYRIRDSSLSSPLKCGYCPFLAETETEFSGHIESHFGERRFKCSHCEYSAFDRSSVQRHVSSVHADTDAKVVDRNEVSRMAHEYIKGQERDRTDLPLVLNLEPEVRVQRIPDSVLLQLNRAPPVGSDSEEDISGGEEEIRDGETKFMEGGEDGNEEEPSGTGSADAALEDNSYGEEEKLVMEGVSDDMEVLDNEEVEKEVEEHDESEAHDDEGGEEEEEVDNNSDEAEEEEVEEEEEEEEEDDPSESDKFTHELGLTAVQQQQSSLLDSDPDMMIMQFGGVAGGAYPSCGMVGAPQSGGGIPSPLPHRSKDSLLSAQEEDEDVASSENVANVEEGDDDEEDDDDDDAFGHDVTLASPLPMISLGDGVTMSPVAADNSGEDGGSAAGLGLGDDTLNLGSGDNEEMLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHP0</accession>
    <name>A0ABM0JHP0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Ubiquitin-associated domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101848184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005093888.1">
        <property type="nucleotide sequence ID" value="XM_005093831.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093889.1">
        <property type="nucleotide sequence ID" value="XM_005093832.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848184"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="306"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005093888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005093889.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38833" checksum="0AB98CE4333AC482" modified="2025-10-08" version="1">MIALAGPAGFYGAPATKVLLCHAIITYFLFAFPLQHFHQLFHYNQDVFEKRQFKKMLVSKLVFLELPDLLFSAVLFYNFRIFERRFGTRKFVSHLLSTTIIASILELLVFAVLNRLEIQLGTMPSGLFSMVFPLFVPFFCTIPRVAIMRVVGVPVTGKTINYILGLQMASAEVENMLVVACALLAGILWRANFLKVQAMLQVPVFVARAFEYCLGRFLESPDLQKTSLPMGATLELQQRERLDRIEQQMMASAIQASRHMDIGRPQPINVAQGPGIFGNVVRRAGQAQAEQQSPDDSGSASSSGGAVSEDQVQRFVEMGFNDAQVRQALRFANNNPRLATNFLLQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHR7</accession>
    <name>A0ABM0JHR7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 431</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093930.1">
        <property type="nucleotide sequence ID" value="XM_005093873.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857935"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005093930.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="49941" checksum="931BCCD3B29E05C3" modified="2025-10-08" version="1">MSNIEDATLEAYKGYSQGTAGSDFDVSALIRMHCARAYLDACTSVLNAKMQDIAKFQALNTPAAAATSDTVAAERFPPEQPLPDLPLLPDYSNVTTPAETSTGYSTRPRRKKSASSAAAAAAAASTSGGTTESAAGPSTQRWAGTKKRKGYRAKRYTGASVSDANGSASKTGGEGGRGGSEHTNSVASSSSSTSSSSGSPAKAKVKKLPGEKPYKCDTCDACFPIPSALKKHYRKHTGEKPYQCSICEARFTRATGLKTHFLTHTGERPHKCYFCDAMFTRYDHLKMHIMTHTGEKPHKCDFCDARFTRKTHLKTHRMSHTGEWPYKCEICHAQFAYAEQHKAHSYSHTGVRPYKCDICDAGFVRAFHLKTHKMTHTGEKPHKCVVCDARFTRPFHLKRHEKTHMKEILQVRVGAMNTQPMMTQEPEKMVDKDMCRQMQMQTLKMTSHQFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHT2</accession>
    <name>A0ABM0JHT2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ETFB lysine methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein N-lysine methyltransferase METTL20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC101846121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. ETFBKMT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093965.1">
        <property type="nucleotide sequence ID" value="XM_005093908.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093966.1">
        <property type="nucleotide sequence ID" value="XM_005093909.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824531.1">
        <property type="nucleotide sequence ID" value="XM_035968638.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846121"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050078">
        <property type="entry name" value="Ribosomal_L11_MeTrfase_PrmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43648">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43648:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005093965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005093966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035824531.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24459" checksum="E342CA58AD65483C" modified="2025-10-08" version="1">MNRLFLQAMVKQHTKVTRVHLTPEVGLHLITPQCHLWRSPGESSPFDDPFWAFYWPGGQALTRYILDRPKCVQNKCVLDIGSGCGSAAIAAKMSGASHVLANDVDPVASVAIDLNMRENSVKLDINTKNLLSAKPSGAANVVLMGDMFYDPDFAQMIVWWLQHLSPDTTVLIGDPDRLPFVNHPMKKFLHLVADYELPQDCRLENNGLTQGKVWMYKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIG1</accession>
    <name>A0ABM0JIG1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein AF-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005094373.1">
        <property type="nucleotide sequence ID" value="XM_005094316.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855777"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16906">
        <property type="entry name" value="YEATS_AF-9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040930">
        <property type="entry name" value="AF-9_AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052790">
        <property type="entry name" value="YEATS_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827:SF3">
        <property type="entry name" value="AF-9 ANC1 HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827">
        <property type="entry name" value="AHD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17793">
        <property type="entry name" value="AHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005094373.1"/>
        </source>
    </evidence>
    <sequence length="818" mass="91670" checksum="50750B3724354115" modified="2025-10-08" version="1">MTMASKDSSDCVVTVTIELGHQANFLKEPSPEGFTHDWTVFVRGYEGSRLEYFVEKVVFRLHKTFKMPVRVISEPPYRVSECGYAGFILPIDIHFKNKQQPRKINFMYDLFLNAQDGPPVNNVRYEKLKFQNPTPEFKAKLIKAGGVEQGVEPTPQPFTDLFGTAIKPKAEKKRGPKPSKDPLKEKVKKKKKKSVSPAQSLSSLSPTTSDDEEKIPAKKEKELSPKKESLHSSLMSKKELSHKEKDKTSSSKHKLDSLHKEHVSSEREKEVKPVKHKSKDKKKDKEKEKEKSSSSGHRDKDTHKKEKDHKSKDLEHKSKVTEVSSKSKETDSLKEKDSSSSAGKTSSSASHSDRKSSGSKEKHSHKDRESREKDSSTSSSKEKHNSSSKDKEKHKEKSSSHKSASQPSLSSTSEGSKRPKEDSGKDRSSKEKDRQEKKSHKRPVESPAREEETEHKKFKSAPSSASTEEKTVKPKEKEKEKSSSNVTKPPKEGKSSSSISKDKPDKSKHSSEHKHSHESKHKSKPKKEEEKDATAVAAKVKDPEKVKEKKRVKSEGLSKSQKLALTADFQPQLLLSPIKSQSEEEHEEPRELQSPGAEERLSVSDTKKSSSRSRHRSSSLSSHSPSAVNSDREALEDEEKVKQITSGLTDSDSDSEEDQPSINSSHKDLKNVFSKQTNDSESCEVSKPSKNSPELYKKGVQEPKMEKDGSSNSKKVSKSHSKKDKEEKPSIVEVVKSEETETRGLDILAPNGIPIGELISINEKIEKAQLEANQSLLDKVVDVIGNTDDFDLDDTALFFDICSVDKNVIFQIQDILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ90</accession>
    <name>A0ABM0JJ90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Something about silencing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101856331</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094902.2">
        <property type="nucleotide sequence ID" value="XM_005094845.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094903.2">
        <property type="nucleotide sequence ID" value="XM_005094846.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856331"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="5">
        <location>
            <begin position="329"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005094902.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005094903.2"/>
        </source>
    </evidence>
    <sequence length="398" mass="46116" checksum="1D26E9AF40AEA2D8" modified="2025-10-08" version="1">MKTKRKRNVSSKQNDRNHSGSDSNDEGNMEDIFTDEINDFTQARNKIELGAVLKDSDEEEELFALASDEDDSDEEINEWSKRLKQVKFQARLDKKKNLSDAPEKSWGQKRADFYGSGVRRKPKEAENEEEDEWLMEAREIEKLQQKMDEEMDEEDFLVTGLGQKAAKSKSGDLKVKRDLSEKYKMELQQQHYPQMEPLRAELSTCVSRVEELKDTSGWKAESQETVYRMLGAHIAFYLHLLETGQDTRGHPVLPRLLQWKKLAKVYESFPPDWLVDSEEEGPGDAEDTRGVTATGDPHSSRVRVDADSGDSEEERDDDIMEEDETAELQNRPVTYEIEKNKAKKKTAPNNPRVKHREKFRKAKIRRRGKIRDYKPELVKYRGEASGIRSGIVRSMRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJB0</accession>
    <name>A0ABM0JJB0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">60S ribosomal protein L23a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101848030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094951.1">
        <property type="nucleotide sequence ID" value="XM_005094894.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848030"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_uL23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005094951.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19453" checksum="B76B0635AE108130" modified="2025-10-08" version="1">MGPKAKKPAAKTVAKKDEKSAAPAKADSGVVKAKEKALRAKKSVVRGRHDKKSRKVRTSVQFRRPKTMKLPRNPKYPRKSVNRTNKLDQYCLIKYPLTTESAMKKIEDNNTLVFIVDKRANKPMIKMAVKKLYDIEVAKVNTLIRPDCEKKAYVRLASDYDALDVANKIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJC5</accession>
    <name>A0ABM0JJC5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">UDP-N-acetylglucosamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC101852088</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094970.1">
        <property type="nucleotide sequence ID" value="XM_005094913.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094971.1">
        <property type="nucleotide sequence ID" value="XM_005094914.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824744.1">
        <property type="nucleotide sequence ID" value="XM_035968851.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852088"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005094970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824744.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41065" checksum="106EF34B86E71463" modified="2025-10-08" version="1">MSTPEEKFQPAAVTSSSSFPPVDLTMNKKGTYTDAGSPKPAQTTRASMKYVSLVLLTLQNAVLILVMRYVRIREGDMFVATTAVIMSELFKFCTCLLIIFIQEGSVQRWLQLLYQDIVCEPLDCLKVCVPSLVYVLQNNLLYIAVSNLDAATFQVTYQLKILTTAIFSVAMLKKQLSRFQWFSLVILFVGVAIVQMQPENTGSKTKVATEQSPIKGLVAVIISCFMSGFAGVYFEKILKGTRQSVWLRNIQLGALGAVIGLVTMYVKDGATVQEKGFFNGYDLVVWFVVCLQSFGGLLVAVVVKYADNILKGFATSAAIILSCVASMYFFEFQLSLQFTVGAAMVMLAVYVYSKYVPTQQNPPLLNAPGRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJP9</accession>
    <name>A0ABM0JJP9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-related protein Rab-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095256.1">
        <property type="nucleotide sequence ID" value="XM_005095199.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859696"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005095256.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22184" checksum="5BB34C61C3EB1C21" modified="2025-10-08" version="1">MAKKTYDLLFKLLLIGDSGVGKTCLLFRFSDDAFNTTFISTIGIDFKIKTVELGGKKIKLQIWDTAGQERFHTITTSYYRGSMGIMLVYDITNVKTFDNISKWLRNIDEHANEDVEKMILGNKCDMDDKRQVPTARGEAIGREHNIPFLETSAKANINVEKAFMNLAQAILNKTPGRISEPSGVNMSQQDTTSKRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKA3</accession>
    <name>A0ABM0JKA3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H4]-N-methyl-L-lysine(20) N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.362</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101863176</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.362" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005095695.1">
        <property type="nucleotide sequence ID" value="XM_005095638.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863176"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19186">
        <property type="entry name" value="SET_Suv4-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025790">
        <property type="entry name" value="Suv4-20_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044426">
        <property type="entry name" value="Suv4-20_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51570">
        <property type="entry name" value="SAM_MT43_SUVAR420_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="112"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="649"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005095695.1"/>
        </source>
    </evidence>
    <sequence length="957" mass="106538" checksum="73DF3813A1E0852B" modified="2025-10-08" version="1">MASSGSSRVMPSTGMSSAELCDFDDLCTALVLDPYLGFMTHKMNTRFKAVNHPEQLKKIVEQFKEHRNYEKALEALIKVDSHRTAPYHRMKHQMKLLREHTYRYLQMFDSVSGFQILPCYRYSMEGQIGGKLCSTKFWHKNDKIEMLIGCIAELTAEEESHLLKSGENDFSVMYSCRKNCAQLWLGPASFINHDCRPNCKFVSTGRDTACVKVLRDIQCNEEITCFYGEDFFGDGNSLCECVTCERRHMGAFRPKQPVNLSSQKGYCFRDTDDRINRLKAKPPESQPTFGNVASNSNESWDNRAKNIQSQSHLLNAAELKRRGITRYDAEIIISNGQPLPEPESPAPKSGHSRSGQLTNSSSKVLRSSGNVVLEQDILNMSNHIRRPPARDDACSDRGTTDFSNSKTEVSGCNKKSPCAKFRKLQGNRRSPRRRAPLQGKGTVGLLEKVPIKEEPMDDFEDSGLSKSLGLAERVSESQVKEEFGSPSRKQIKMGRSSEDVTDDGREFTDAELRSHNLSDFLDNSPRLKSHKEKTLSRLFCSNESEGNAIPNSSDNSLPPLISMEEHPLSFADLAARTPLKHVPLSSSTPVRQSPRLHRGTTQPLADSKTLFSGNKREKAVNLAKELNSLVAKASTCAQRLTDLVMESSLTDGGESYQDPPVLEPEPPIISPSVSRRSSADDMNDTLFSNIFGTSGDLQFHKRSKSVDDSCLSDCLGKPLSLLTKVKDENGIFSKSDGFRYHRRNSFDEFGKPPLLKKDHCSCAENNNAVDQEGTAAKPPNVPIPNHFHVGEDIYLKQSRVQETNTRATGRTRRRQPKLIFRMKPDPELKKQLREESAQCPNANLQFKWDDDSDVEIGRSPTGGCATTLLKSKDPFCPAVAAKKEKAEDRVLLGSFSGGAIDSMGLGQLHDTSSSSSNSSVSSKTSGSYRKVRKVRLKMIDTSLHFDLVSPSASPSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKZ4</accession>
    <name>A0ABM0JKZ4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101854249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096159.2">
        <property type="nucleotide sequence ID" value="XM_005096102.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854249"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="71"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005096159.2"/>
        </source>
    </evidence>
    <sequence length="359" mass="39892" checksum="A2B714B127B7954A" modified="2025-10-08" version="1">MAGVETMEVDQAVESEEAVSKDKVATQQQSTKKSGGYETPWVEKYRPTKLENIVGNEETVSRLAVFAREGNVPNVIIAGPPGTGKTTSILCLARALLGSSFKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIFSKTTRFALACNSSEKIIEPIQSRCAVLRYSKLSDAQLLARLLDVVKAEDVSYTDDGLEAIIFTAQGDMRQALNNLQSTFQGFGHVNSENVFKVCDEPHPVLIKDMLGHCVLGHIDDAYKVMAHLWRLGYSAEDIITIVFRVCKNHNMPEYLKLEFIKEIGYTHMRLAEGVQSLLQMSGLLARLCRKSAEPNTLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLG2</accession>
    <name>A0ABM0JLG2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="3">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101846955</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005096479.1">
        <property type="nucleotide sequence ID" value="XM_005096422.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846955"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017194">
        <property type="entry name" value="Transform_growth_fac-b_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF71">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037393">
        <property type="entry name" value="TGFRII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047236800" description="receptor protein serine/threonine kinase" evidence="17">
        <location>
            <begin position="25"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="203"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005096479.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="59506" checksum="159A6CE21A01333E" modified="2025-10-08" version="1">MSIRSNVCVILASALMVFGGPAYSSTNMSDPDKKQEIQCVCDPPTCSQANHCNTTGKCYAYEDPITKHVVRNCFLEDQSALNCKSKMSKYSAFKCCDTNLCNQHLQPTLPSVVGGEGGDDTLDSTSIIIASAAGVLLLCVVVFFIIVLIQRHLRKRRERSLFMAPEARLLEEDLSGKGYQDQWSAGSGSGRPTLVRRTVGQHITYKERIGKGRFGAVWRGVWLDEDVAVKVFTSLEETSWNQETEIYNTGMLRHENILGYYASDTVGMNSCTHNLLIVHYHENGSLYDYLQCSDIDMEEMLILAHSASAGLAHLHTEIKEGTGRHGKPAIAHRDIKTKNILVKSNGQCCIGDLGHAVRGDVKLDAAPEKLLVGTKRYMAPEVLNKELKPDFFESFKYVDVYAFGLVMWEIARRARPFAEEYRVPFWDVVQADPSFEEMRQVVGVQQQRPPIPNKWSKEPLMCETAKLMRECWAQNPKVRLTILRVKKNLYSMLKSTSREHAEKVEKLSPKILDSSSSASSSRNNSVNTNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMD2</accession>
    <name>A0ABM0JMD2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tensin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097083.2">
        <property type="nucleotide sequence ID" value="XM_005097026.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852014"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14508">
        <property type="entry name" value="PTP_tensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF10">
        <property type="entry name" value="BLISTERY, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="3">
        <location>
            <begin position="88"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="4">
        <location>
            <begin position="265"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005097083.2"/>
        </source>
    </evidence>
    <sequence length="318" mass="35475" checksum="49E9442EF309D284" modified="2025-10-08" version="1">MSKGYSGGASGPPRVAATMDRGRMPQSRSFGSGFSKSPRDRPPVFRTMSNEAINKNTQSSMRSVGMSSQNQSAMSSTMREMLNRSQEQAQLEQGLSLDVVHITERIISMTFPSEGHDTTYSFDLKEVVRMLKTKHGDHILILNLSEKRQDLTKAAPQVKDYGWPDHLAPPLERLCSLCKAIDSWLNADVRNVVVLHCKGGRSRIASVIAAYMHYSNICASADQALDRFAMKRFYDDKLGGLPLPSQRRYVRYFSGLLSGAIKINSSPLYMHHILIHGVPNFDTKGGCRPFIKVYQGMQPIFTSGVYNVTDNMQKVCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN71</accession>
    <name>A0ABM0JN71_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid-binding protein, heart</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101859403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097638.1">
        <property type="nucleotide sequence ID" value="XM_005097581.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859403"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005097638.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15630" checksum="14B4047E6D345A13" modified="2025-10-08" version="1">MEPFLGTWKVVIEKTSGVLELGKLFGWEEGKAEMVSKLEYTMLLEANGDTLRAFLDYGNPKLEFNFKLGEEFDYTGPDGSKAKCKVLMEGGKWVEYYRVPEKPEATWTTTRELNGGEMLATTLFDAAPDVKCNQTLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNN9</accession>
    <name>A0ABM0JNN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetratricopeptide repeat protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097943.1">
        <property type="nucleotide sequence ID" value="XM_005097886.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847653"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21380">
        <property type="entry name" value="CTWD_Cns1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="279"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005097943.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45893" checksum="4FD83954A310DF36" modified="2025-10-08" version="1">MPKSKKAMSDEERKELVERLTADLEDFVAERSIAARNRKATEPEDTRTIDEIAEELKSHPAFMKDIDWSKPLPPEVEGLMQLKYECEDPTARADSYREDGNEQFKLKKYQIAIDNYTEGIKSKSPDAELNAVLYTNRAAAQFHLGNHRSSFNDCLFARKFKPDHFKAIIRGAQCCFQMNKFADAVRFCDAALMVEPENPTVLELRVKADKGMRARERDERKQAAKERKEEEEDRKLLQAIQTRGVQVASMKVSPDSKINPLLLTALESHNPTGAKVHLDDQGHLKWPVIFFYPEYAETDFISAFDEEACFSDHLEHMFGPETPPAPWDEENKYKPSRIEIYFENKDEEKLYRVSPESSLLDALRHKKYLVYAGTPGFIFLVRGSKFAHEFTARYRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNS2</accession>
    <name>A0ABM0JNS2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101863667</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101863667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098003.2">
        <property type="nucleotide sequence ID" value="XM_005097946.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863667"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045393730" evidence="6">
        <location>
            <begin position="16"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005098003.2"/>
        </source>
    </evidence>
    <sequence length="444" mass="48503" checksum="BED376E2F0426099" modified="2025-10-08" version="1">MKFLILTACVAVATAFTPATKPVCNADNNEGGSLLMSHENYCQLYYSCNGDQQAFEMTCPDGYLFSWDEGLANCIPPDGVTVTCPNWRCLSSDIGNRFPDTCCSKYWECTSGGRYEQRSCSNGQTFNSVSEACDTSPCTSNRYCIDNILPSSETHCHDVAEANSPCTYSTVWAGVTTPNRPCPYGTRFDTTTCSCSQIDPACRNGQLTAELLASNKAINVACQVSRRVDFTQLPLVTFSEKINSQLGHFFLTPGVTVQNNEAVYTNGNSGSYIYDYFFNDNILTAPLAITMTVRFTRAPLPNTEYVLLNNEFSLDPNNPLCDPATISIRARYDNIINGARSWTFQISATGELNNVAQGSATITGDLTDYFRIEYRFSGTLSGTITNRGINANQNVRSSTITSSTNIGGAIKPNKCGFMIGRGLTGRIRNFNIYEGCGNFANIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNT3</accession>
    <name>A0ABM0JNT3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransferase family cytosolic 1B member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098027.1">
        <property type="nucleotide sequence ID" value="XM_005097970.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850561"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="52"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098027.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35587" checksum="F65275DE51DEA2EB" modified="2025-10-08" version="1">MSYSNKEILERAREELKKSEDCVFEGVRYSTLGLVPDTPRMFHKIKHVELGDSDVILNGYPRSGNHWTFEVIGAILNQDIGNEKDDFLFRLMDFMGDDVESRIHGLPAPRLINSHPWASRLPEIIRQGNVKIVYILRNPKDALASWYRLLKDFISPYGFEGTWEECFELSLTGEIPFGSWFDHVLEMEKFMKEYPDSPVHVVLYEKMKEDPVSEIKKLCDFLDRPNVDVEELALATSFAQMKKKREPIYKQSEKALGREGCHGVMVKGVIGGWREWFTVDQSERYDKAFEEKMKGSKLADMVREYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNZ9</accession>
    <name>A0ABM0JNZ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Soluble calcium-activated nucleotidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the apyrase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098146.1">
        <property type="nucleotide sequence ID" value="XM_005098089.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857251"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.100">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009283">
        <property type="entry name" value="Apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036258">
        <property type="entry name" value="Apyrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023">
        <property type="entry name" value="APYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023:SF3">
        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06079">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101887">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005098146.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46918" checksum="E5B34CCA9942D4C3" modified="2025-10-08" version="1">MLASRVHYAYPSLFSVHMSLPVEDEDVNMLSSSPYPSTVHEWTKAIRRPTSYRVGNARFHLKPKVVLYAVLLSVSVLVLLFMFMPKTTPIVKCDAEQQLSNYDPTYPLTNPQRIAGSIVYTIGLITDLDTNSKSKEKKSTWLSYYRKGNLTLSESRTYVNVKLGSPKVLFSNIASGDRGMELSELVVFNGKLYTVDDRTGIVYEVSGQQVIPWVILADGNGKANKGFKCEWATVKDHRLYVGGLGKEWTTGTGEVVNLNPQWVKSIGRDGDVKHLDWHERYNALREKTGMLLPGYIIHESGVWSDVHKKWFFLPRRASTETYDEVKDEKRATNLMFIADEDFTSVEIKKIGSLNPTHGFSSFKFIPGTEDSIIVALKSEEDNGKIASYILAFDINGNTLMPEKKIGDVKYEGIEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP58</accession>
    <name>A0ABM0JP58_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline-rich protein PRCC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098263.1">
        <property type="nucleotide sequence ID" value="XM_005098206.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864065"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098263.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="57257" checksum="63352EAE9E3313AE" modified="2025-10-08" version="1">MSLVAYGASDNSDSENEEQQEEPASQSRQSENNNRNVRSSGVISDEDEYESVSSTSVAAFSNSKKSLGSDSLMGAVSVSSAFENQVNSTSVTSLDDLPAPQVRPTLNADADTVEDDLEEEVKPKAAEIASAPKPPGKKRQPVKITIPSLDETPEEVKSESKRPVSSSTTKNGLFSLLPAPMHSAKKEINRPLIPHSLTKKPAAASKTSSTTASSKKTTTGTHTNSRSEVASSSDGSSKRMSQFNALTGYDSDSDEDNEDGSSSSNFFSLNSSAQKNSKDSIATSLSSSSSRLQSEEVSSSKSDSNLGAGNSKTSGQTLVTDVKDSEENVPEGSSKEGGDEEEEEAEPEPEPGSVNDAPLDFGSVNRLNAWSGSSYGFLNPVGLSGPVVPSFQTQQAMPSNSLYNLANAESAQSAIDDESDEVPGDDLKQFMSDKEFQRFQGKRKRGMEESISFVDAKVDDYVDPSEVSKHLTEETEYVSNKNKDNMPTSQQKRKKQITYLAYQAKEKELELKNTWAQNKMTKKQTQSKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQK9</accession>
    <name>A0ABM0JQK9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101852477 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101852477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099236.2">
        <property type="nucleotide sequence ID" value="XM_005099179.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099237.1">
        <property type="nucleotide sequence ID" value="XM_005099180.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852477"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099236.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099237.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="30427" checksum="A8206725DD527219" modified="2025-10-08" version="1">MAASGILRKGLLLNGWLRQSTRLVASQQLNVKLNPEGLRHFSRLNATPQSLCLLQDIKNPELMSLLPLRSLHQSRAVQEAAKKPIEASNTTKAAGDVAASGASGSSTAKKVSSSFLKSSRGEGKGSSGKGESRWQYYLYGGLAISTLVGLYRMRNQSRHEMLTAIKENKLQSTMQPPEQVKMDEKLPPAPAGREEKASGSSNVKVEKTVNAALGQAGGDVSHCKPSSPSVRIHSDGAKPCSTPLNKRKYPPKYKSVKESSCLKVVRGTCDCDTPDPCGSPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JT22</accession>
    <name>A0ABM0JT22_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101850339 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100843.3">
        <property type="nucleotide sequence ID" value="XM_005100786.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850339"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046432">
        <property type="entry name" value="TASOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022188">
        <property type="entry name" value="TASOR_DUF3715"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207:SF11">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12509">
        <property type="entry name" value="DUF3715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TASOR pseudo-PARP" evidence="2">
        <location>
            <begin position="84"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100843.3"/>
        </source>
    </evidence>
    <sequence length="1230" mass="135059" checksum="1E91A204033A2B0B" modified="2025-10-08" version="1">MEAFPSKRKPATRLPQFNLPKLKKIKRDLLTNLQLDSHECQYEILAVVRKSFHFRDSNTCYEFLKVQAVHNPELTGKYLERRKEMKSNGYPDAIVADTYAFVSVDSSAMAEKICKEGLRCGNQQTSALGVPSMAVHLCKHADVVTPSKPKPGERMMLVFKVVKGKVKTVLCKNTSAQLEPTPNCDCHVAKTNVDQTANLAPHMFFYSTQLYVYEYGDFDLEDYPRQVLPYAIVSYKVTDPQLMPKPMSNLPQLQQSSMLGHQVPSSTAASLESPSAQNSGPSNEVWKGRLHVRLTEGGHIYIEVSIFSYFVPLTVNLISPIKIHALYPEHNAQFTFFAGLTNISQAEEVEWREHYFRSCLMRPRSNNEEHFKALVKHISTKREIPTVRLPNDVFMFLMPNSLLSSQLGFTRSEDRAPVLHCVLMSKFSTIKAEKKKLSKEKKVVFHNLGRATSWENLFDDSDFSEDDKETNKSSLKGKLSVRQLRGMFDCQRGIHNKFAAMSLMDADVNFGTCACRKLSVAKSQQQLRRDEDVKRVFAAVQSAVHTSTKSKSHFPPGSRHKPKQKMSRRAREMPSFSPHGSSESDSDSKDSSDSRRTAEKRKQDRFSLLHSTKTVEEELSEEDELTNEQMEAIIFLRKPALSTSSSVLKVKTPKTASPVLPEHKSSLKSSHSTSDLQKTSKDPSLHLRSTPKIIPTEPMEQIKRNPALRKDTGQSKYDSVLRKEADELRQELAKLQPKIIPTEPVVSVKEPFSSSNPAQARAIVGTTVVPKPLKPSLGCTDIPKCTSSEVVTSSLNHIAACHDSNSKTKSSPSSTDLYRHTNSISSALSFSFSDSPVPNSSRTSVAESSHSHTAASVPTNSKISKSSSSLSTASPVTSSKPLKSCLSRSNTTSKTDPTPVKPCHGLSDTSFQVSSKPVKNSLGNGNVPFCSGTTSNPVKSSPLVSDAPMCIDSPKKRGAFPSHEENDSEDVDMRLPHSHIPQIHPAFLSASTTMTSPLPSHGQRQHQSILKSPSKLFVSSPSKEQKGQLSPNLAFGSWLAPGEVLPQQPQTLLNPAMSDSQQKDPFTNSSLEPFDAPSPVSLPDESPPSPAPIASPVDSPASPMESPASPPSPSPLDSSESPESPPQSAYSTQFRSSPIAIPTDRVKLDASPEANHSHIAYSPTLSYVPNGAGVSVSRDGIDSIEDMKDFLNAGFDSDLDSSYDDDSDFTPLEGRGPFAACCAQASQGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU55</accession>
    <name>A0ABM0JU55_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101858869 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101858869 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101858869 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC101858869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the geminin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101556.1">
        <property type="nucleotide sequence ID" value="XM_005101499.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101557.2">
        <property type="nucleotide sequence ID" value="XM_005101500.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939783.1">
        <property type="nucleotide sequence ID" value="XM_013084329.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858869"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22589">
        <property type="entry name" value="geminin_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1180">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022786">
        <property type="entry name" value="Geminin/Multicilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13372">
        <property type="entry name" value="GEMININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13372:SF5">
        <property type="entry name" value="GEMININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07412">
        <property type="entry name" value="Geminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111469">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="147"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005101556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005101557.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012939783.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31091" checksum="D65C7E3324C7AB03" modified="2025-10-08" version="1">MDAGLTRRTKATMFVAPKDHSTPKHHSAQNERKNLQTLQSAAQGGKRLNGGKHENLLVSKENLVQPEYSGSHSPVQIYQDTSVPPECPVITCCRNTQTDDSLLDCLLQERWQSLDSVQGDSGRGSTLGEQETLGLLVDDTPSGTYWKELAEERRIALKETLKENEKLCTEIDNLKEENSRLADIAKKAEALQELLSDIVEDEEHTGGSCQEPEGDSQFVDSLKDEDAEKLYADLDQAASTSKDPQSDSKTQDPGIYSSAGTAQESGSSTNSQVSEAQFKSEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUK8</accession>
    <name>A0ABM0JUK8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101848052</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101852.1">
        <property type="nucleotide sequence ID" value="XM_005101795.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848052"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="823"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101852.1"/>
        </source>
    </evidence>
    <sequence length="1705" mass="187604" checksum="DCF0EF8EAF7356C4" modified="2025-10-08" version="1">MTTVAMKQSTLAGLFSPKCGLQPQTKPPSDSETAHNEHTQEKTQDTEKQCSSESENTKLKKDQPKSKKVKSKLSLSSEAPNSQKKKQQKRKEVAEFEETGANTNISRKSKPIIENSKAVTESSTLKVKEEESDVKASDEKETLSYEDFLGMFKPANLGEPVNTENEEVPENIKDEPESSVPEPVKGMVQCRTITSFFKKSSVKTIDSKSEVKSSAQTVTVDVHRDALSKIQQKQDTSLATSINKKCEKTLKKNESKGSQHDDNEIILLSSEIIVTDDKDDIGHDMSAQKVGNKRKCDNTARTEGSEIKKVKFDESGKKGTSKEETQGMVVDVEAPVTVNDTTQENASVPSASSTKNPSLTRTQSKLSFGKSGLSVVKPVLNVEEDESKVNEKLSDRIEVSVQSPPKTVEETMDVGVGTSDAALTSTETEKGKKKGPSGTRNLRSRDTNVHETQNTEDSPTQPTTSLRRSSRTTRPIQSFKEVEVMEVDVDDDEDEKKINEKRCKELKRPPKSEMKTKSPLPREPEKKVPGKLAPIFTKVKAAEEEAPIPVEDPEKARLKREFLMSGVPEELKRLIASNTLSNVSGDYPPFPKHNHTQQLDGQTVHKSLVQLKVKIRGSDGQVSPGDYVESKNWSRMAFSRELDYQDAALVPFKNFSAHPILPKEFVNVVLADFQNSDGKFPFKETYQYLQSQLTLGGMSGAELSKKCPAETLEDSVIVVDDEGPQAETSEELARSQLYKNCLWSDLHFPNNSKHLIGNAKAIQHMKEWLVEWKLLMEKEASREKKGKKKGRSLTKEKSESKESDWSDDSDFIDSDEEEEDLSLCNTIVITGPHGVGKTSSVYALAQEMGFKVFEVNASSLRSGKQLLSQLEEATQSHRVSRSKMATLQTPTSISQLGKQEVENSEAKSSKKGKKTPQSSSKPAGVNSAFANFFRPVQKDKAQDTPKTTRGRDAKGKSDRVSSRQAEGTAVETESAKKNTKNSRQKAKRLKRNEDEDVEVVEMPEAESATASSGSLNLTSSSLILFDEVDIIFEDDRGFLATVQHFMTSTKIPIVLTARDVSFHHQLSARHEHLVFKRPPQRTIASLLCTVCLSHGVRVSHRSMLNLASLTKGDIRRALLQLHFWCESGGGTSQIILDLIGSPQKESHKPSSGKISPKSLGGNVVSKEEQAPVKDDDENVSDVKPVFQRDSSDDDFTCLKFERKRRGRMVLDDNASTSSNVSVASSQESSTAKCKRRKQQKQRKSKRDRRGGKTADEKTGRRAKHAKDDSACGGGGDDGMNTSLEQTVFPPVHLGCEEGVLAMRNSVASSTAIINLIKAPLVDLEPAVHVCGTLKSLLESSAVYRLALHSLPLPRADSLLIQLTLPHTSAQTASDSPAKNAWKRIVVGNWLDSDSSSDGCGKDVSKPAEEASAKDAADEEPSSQVEKTSDDKSSKSEGNVDGAAKSEGNVDDAAKSEGNIDSAERQEHLLSGDGESKVLVKEGRLVWTTLRDLAQYYDCVSTTDVLEASCPGVCGGQEDLAPGMDDTEVRPSGSSHCSQDRWCPEFVDSMHLLSARRLCSQVERRLAEYHGNGSVGDSATDATGDDGQSEERSLSALSGQLDLPIGEKLPDVWDAVGAAELSKNKNALVRNVCDNLGSWHRDCDLAIHMDYLPALREMSRVERERQDTNTKRRFYHYFDSISFGLKPQTVVELASTYTVVDNSFCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUU5</accession>
    <name>A0ABM0JUU5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine-hydroxylase NDUFAF5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Putative methyltransferase NDUFAF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101852554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102037.1">
        <property type="nucleotide sequence ID" value="XM_005101980.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852554"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="7">
        <location>
            <begin position="115"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005102037.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="45841" checksum="C15EF75CB347CD0C" modified="2025-10-08" version="1">MMSQRLSYAVLNRQLQLLKWPSCRSLLGSCDDKGQQSQRLRQRCGQMKFNREASTKTQGTIMNVFDRKAKRLQKERAALGDDGEDVTVYDYLKDEFGYRISDRICDIKRKFSVAVDLGCGRGHVAKHLYSDMVERLFQCDLSHSAVKLAEVSSEVPTSKLVVDEEFIPFKDNSLDMVVSNLSLHWVNDLPGSLRQILQALRNDGVLIGSMFGGDSLYELRVSLQLAEIEREGGFAAHISPFTTVNDLGNLLTRAGFTMLTIDVDNVIINYPSMFELMFDLKGMAENNCSWSRKSKLHRDTMVAAAAVYKEMYGNEQGIPATFEVINFIGWKPDPSQPKAAARGSGEVSLKDISRIEQLSKQMSHGDHKTSDGAEAQIGKLEEELKNLSTKYKTPDGSDGGGSEGSGGPGTKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUW4</accession>
    <name>A0ABM0JUW4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methyltransferase-like protein 17, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101859579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005102066.1">
        <property type="nucleotide sequence ID" value="XM_005102009.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859579"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="494"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005102066.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="61162" checksum="9CE4641204D2C148" modified="2025-10-08" version="1">MNKVGVLSKPSIFLRILGQSGASLVTIRGPLSYCQGVFICRSISESQADTDGLPLSHVITRESKVDSSVAQRLEARQGSANEFIKYRGHDGVMRRTRTQVPTRLIKAMKILMEKYPMESVTAKAEQLVKYLTQRQPPLSDQEINDKAVAVERKLLEKDPNKFENLSGADLEDAIDQHRKAVLSRLRKTIYNWKPMNFDAFTSYTYMVGRTSFDFSVIMQCFTEISKRDLDFQPSTVYHYGSKVGACVWAADKTWRSIGEHYCVDSSSHMSTIARLLLQDGNEQETVMSIKGVHFRQFEPSPKENKFSLVVSPFMLIEQPSAEERMNLVLSLWEMTESYLVLIENGTTAGFNLINEAKEFLLNVSQVDGTSRFQGHVFAPCPHDKPCPKLREQKMPCLTECVHKEVDIKSSKLSEKPKKNARYSYVILKKGVREEEEFGWPRVLRQIKAKRHTHCHLCLPCGQLQHVVITKGKFDKHTYGCARYVTQGDRLPLSLSRQPGAVPHEPSEEHIPVDWGEEEPEQSGTGDDGNSDDETTPLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUY9</accession>
    <name>A0ABM0JUY9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Dynein heavy chain 1, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC101852702</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102124.3">
        <property type="nucleotide sequence ID" value="XM_005102067.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852702"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="13">
        <location>
            <begin position="598"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="14">
        <location>
            <begin position="1126"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="18">
        <location>
            <begin position="1620"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="21">
        <location>
            <begin position="1973"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="16">
        <location>
            <begin position="2132"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="15">
        <location>
            <begin position="2407"/>
            <end position="2750"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="17">
        <location>
            <begin position="2780"/>
            <end position="3001"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="12">
        <location>
            <begin position="3247"/>
            <end position="3359"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="19">
        <location>
            <begin position="3392"/>
            <end position="3531"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="20">
        <location>
            <begin position="3537"/>
            <end position="3837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2629"/>
            <end position="2705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_005102124.3"/>
        </source>
    </evidence>
    <sequence length="3841" mass="439186" checksum="01C071B3C352C295" modified="2025-10-08" version="1">MNTFLQYFLKFRIKEATEKVKKEITLDYCRVMNKFVLDKAVSDDPATFAFVTVPIEYEKPAPMYSKCPDVPAYPYQSQSDSFSYSSIYTMAESIEAMVLVRTECNNVANMSLLNFKVTKLFKIQDFGYLQTQATVVTGNYLKENWLNKLKSAIRKSFISVRKGWFNIYEDNWALYQISKLKKFIETVKFMMQDTLRFLVVDSLTNFVQMIVDTCYTTMNVRPTFKWPKSFIQSPFLPRKNPIFQLDLLLDDTSHYSADPEIFSETLLTLFNNAINASWNIPQLEKSIMQDIFWSETPLLEAIHQNETQMRELRDTLQHAIESSFIPLKAYALKFEIFLDLVNLEIRDFIAEYEAENHTAQQMAETAQQHLDKADWILEILPYNILIGPFNILVDGVRDQLIAKHRDLAMSVLALLARILRRKADEMSGDFKGMVNRITDIPNCIEELFALRDWINEVPQKLDVAREEMAIVLQNYEVLDAFNYNLADEDFTAKITMIGWPLKIEEMCEKKLEDLVEDEDRYFKQLDSDSIQLAERLENNQIQIAAMAEHSDMEKAPEYANEMRRMYKNLRECQDLAQLYNSRERLFKLKPTNYSKIGKITKEFDPFRKLWITTSDWLRWQESWLTDPLQAINAEEVERCVNESFKTMQKSVRFFSTIPAVQEVAMNIKSNIEQFKPYVPLIQALTNPGLRQRHWDQLSDEVGFKLQPSPTLTFSKCLELKLNDHIEPISRVSEVAAKEYAIEKALNKMESDWENVEFEVHPYKNTGTYMLKSSDEISQQLDDHIVMTQSMAFSPFKKQFEERIANWERTLQLTQDTLEEWINVQRAWLYLEPIFSSDDITKQLPTESKRYNTMERIWRKVMRMAKGEPHVIKICPDENMLTDLKKCDELLDHVQKGLSEYLETKRAAFPRFFFLSDDELLEILSQTKDPMAVQPHLRKCFENISRLRFEEDLQITKMYSGEGECVDLCESLYPVGNVEDWMSEIERVMRETVRQVIAMALPDYLEIQRTQWVLKWPGQVVIAVCQTYWSAEVAQALGKKNLSEHFQVMLEQLEGLRGLVREDISRIGRMTLSALIVIEVHARDVVDKMVQENVNDPNAFEWISQLRYYWLPDENLYQKAVNAQFPYGYEYLGNTPRLVITPLTDRCYLTLTGALHLLFGGAPAGPAGTGKTETTKDLGKAFAIQCVVFNCSDQLDFMAMGKFFKGLASAGAWACFDEFNRIDIEVLSVVAQQIATIQSAQKLKMDTFIFEGVELVLKASCAVFITMNPGYAGRTELPDNLKALFRPVAMMVPDYALIAEISLFSFGFSGARVLARKIVSTFKLSSEQLSSQDHYDFGMRAVKSVISAAGNLKRTNPDMDEQLICLRAIQDVNVPKFLIDDLKLFNGIVSDLFPNVKEEPIDYGILNTSLRDNCTNAGLKDVDEFIHKCIQLYETTVVRHGLMLVGPAGTGKTKCYNMLKAAQTELKGQPTPSLSFFETTHAYVLNPKSITMGQLYGEFDLSTHEWTDGILSTLIRVGTTANNEDKRWYVFDGPVDAVWIENMNTVLDDNKKLCLSSGEIIKLTDSMTMMFEVADLSVASPATVSRCGMVYLGTSVIGIEPFVECWLRTIPEIFFDFMDKMQEMFDTFLEPCLQFVRSSLTEIVTTMDSGLVFSLFRLLDCFINKFRLKPNQKLSDIISDDGQERLGELIEPWFIFSLVWSMGGTCDGNGRLKFSKWLRQKMDEANCQVKFPEEGLVYDYCLDDSAIIITETENEEEEDEEGKPLKWVNWMTDWAQFEVTSEMKYSDIMVPTIDTIRSSYILNLFIINQQKLLTVGPTGTGKTLTIVDKLTRGMDLEFLPEFINFSAKTSANQTQDLIDGKLDKRRKGIYGPPVGRYSVFFIDDLNMPALETYGAQPPIELIRQYMDFSGWYDRKSIGDFRLLVDVNFFCAMGPTGGGRNPVTARLLRHFNFLAFTEMEDASMFKIFKTILEFWISNCPSIASSCDQLVWTTISMYNIVQTQMLPTPAKSHYTFNMRDLSKVFQGILMGDHAENKKVEDILRLWYHESCRVFQDRLINDEDRQLFENVLRQKMKEDFHVDFESVVTIQPLIYGDFLNADIDPRPYLLVDDLHAAQRCLEDFLADFNQGSIKKMELVLFMDAISHMSRITRILRQPLGNALLLGMGGSGRQSLTRLSAFISEYDCFQIELTKNYGSHEWQDDLKKVMMKAGIRDEPVVFLFSDTQIKSESFLEDVNNILNTGDVPNIYSFEDSENIYKEMKPIVMDMGLSPTKTIMFSAYTKRVRSNLHTVITMSPLGEIFRARLRQFPALVNCCTIDWFSQWPTEALRSVALRFLHDIGDLDCSNAVMDGLVSMCQEIHESVTHNSQRYLDEMSRHNYVTPTSYLELLGIYSQLVSRKKTELSVASSRLKTGLDKILSTTVEVARLQLELAEMRPELDIAVKEATITMEKIAEDTAVAEATKAVVKKEEVSATAKAMETEAIAADAQKDLDEALPALDAALASLKSLNKNDVTEVRALQRPPPGVKLVMEAVCIMKAIKPKKVAGEKPGQKVDDYWEVGKAQLQDPQKFLDSLFQYDKDNIPNDVIKKIEPYINNPSFTPEAIAKVSKACTSICQWTGAMYKYHFVALGVAPKRAKLKQAKEELEETERILGEAKARLHHVEAGVAALQKNYEESMSKKQNLEDKCRLCEERLERADKLINSLADEKDRWAESIKTFEVLIKFIPGDVLISAGSVAYLGPFTSDYRGRMVKDWTKSLKKHEVPCCPEPSLIGTMSDPVKIRSWQIFGLPGDSYSVENGVIVNLSRRWPLFIDPQGQANKWIKNMEEKNELDIVKQSSKDFIRTLENAIRFGKPCLMENVGSDLDPSLEPILLRQIFKQQGNWVIKIGDNMIPYHKDFKFYLTSKLPNPHYTPEVSTKVTLINFTLSPSGLQDQLLGIVVAEERPDLEDSKNQLIISNAQMKQELKEIEDKILYLLSVSEGSPVDDLELIDTLDASKTTSQEIQAKVRAAEVTEKSIDETRSQYIPVALNSQILFFCMADMAKIDPMYQYSLEWFIKIFLLSISQAERAESLPERVDNINVCFTYSLFVNVCRSLFEKHKLLFGLLMCVRIEMQKGLLNMEEWHWLIAGGADIPYTVQNPASSWLSERAWNDILTLPALPKFADFAKDFKNHLKSYKDFFDSIDPQDMPLPGKWGEELDDFQAILVLKALRPDKVTNAMQKFVASKMGQKFIEPQTSDLAMVFKDSNVSSPLVFVLSTGTDPAKSLNEFAETMKFSKRLHSISLGQGQGPRAEFLMKAAMESGGWVFFQNCHLAPSWMPTLERLVEQINPDMVSKDFRLWLTSMPSASFPVFILQNSSKMTVEPPKGIKANLLRSYMGFSDKFFKQCPGKVKIFKHLLLSICLFHGVVLERRKFGALGFNIPYEFTDGDLRICIDQLSMFLQEYNDIPFKVLIYTAGHINYGGRVTDDWDRRCLMNILTDFYCMEAVSTSFTYSPSGIYRQLSSDSDLQTHLDYIRGLPINDTPEIFGLHDNANITFAQNETALMLGCLVALQPKTASGGGLSREEVIEHASKNILEKVPNTVGLDVVMKKYPVLYEQSMNTVLAQEVIRYNRLLVVMKRSLKDLLKALKGLVVMSQTLEEMSNSLFINAVPGMWAAKAYPSLKPLAAWITDLIERMNFITKWVDHGIPDIFWISGFFFPQAFLTGTLQNFARKNVISIDTIGFEFKVMKDKEVKKAPKKGCFINGLFLEGAGWLQNEWMLGESLPKKLYSPMPTIWLIPRAGRVKPDTGIYECPVYKTLTRAGTLSTTGHSTNFVFTVEIPSDKPQKHWIKQGVALMCALNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV58</accession>
    <name>A0ABM0JV58_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Demethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101862811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102253.2">
        <property type="nucleotide sequence ID" value="XM_005102196.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862811"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF101">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005102253.2"/>
        </source>
    </evidence>
    <sequence length="224" mass="24830" checksum="1935D23F155251AF" modified="2025-10-08" version="1">MSEGAATTSTLSREQAVAAVKAYIRPCQTPLSLAKVYDDTAQQYDQYMHVLGLNGPQRMVRKVEELLGDNFGAKIIDVGAGSGLAGMELFEAGYKNLDAVDASQGLLKVAEKKGCYKNRICQFVGQQPLPINNDTYDVAVLCGAMGESHIPKIGLRDIIRIVKPGGYIVNVFREEALRVPYYGDGLEPYMRQLEQEGLWKEHARHVFPKNIDNVEGLMLVHRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVL3</accession>
    <name>A0ABM0JVL3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005102577.1">
        <property type="nucleotide sequence ID" value="XM_005102520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854181"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="78"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005102577.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="61475" checksum="E2570A59066C0879" modified="2025-10-08" version="1">MNVEDLVSDLSTCGRFQVLLTAICYLVKTSAVWANMMMAFGSYDPGWTCTAFETIDGGRAENLSSSLWSRPLQGLYDVPGISITGSLSDNASSGALPPGADVRDDSSVSTANFTHSSCEKYPRCKNIQFNHWEARTVATEWNLVCDRAWILSLIISIQMSGVAAGSYICGYIGDKCGRKLSMYGFVTFGMLCNIAAYLTTSWEAYTVVGFFIGVSVGGNFAASNIYAMEFVKPKWRPVISGLPCWHVATLLFGVCIMLLRDWRLVHLATAALSLLALLTAVWVPDSVRWLLVHRKMQKAEKVVTQICRFNGMEMRDTKFGSDAMTEGCNHSQEDSAKYGVFILFQASLRKKTILVTLTYFLTSAMFFAIGFGVESLYGDFYVNFILYSLVPIPLSFLVPVLGNTLGRRWALLIFLSLVFLGFVSIVVVFFTTSGSVRGITITCLALVTANWLQHLLCTLTTFSVELFPTVVRNLGYGFAVTGARLGSIVAPYVIPRDFESIYVSYLIMSAMALVCCAAVWALPETKGVAMEDVIQDNDKPTSLERKEALMNDKTTSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVQ7</accession>
    <name>A0ABM0JVQ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEAD-box ATP-dependent RNA helicase 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101851057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102648.2">
        <property type="nucleotide sequence ID" value="XM_005102591.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851057"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF69">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046726704" evidence="5">
        <location>
            <begin position="29"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005102648.2"/>
        </source>
    </evidence>
    <sequence length="722" mass="84634" checksum="75D3014B69D784E0" modified="2025-10-08" version="1">MAVLLRQLGLHFLVSLLLITFTEHFTQAIDDYTFGCGSTLDLMNAQRRSGLLKVGLPESFAAFQNPSVDNHCDITIFFTSSHNLLLELYYVDIIPLSNEQGCTTGLEVFEQSGLKSLYGGRVCAEAWEWEQRHRESRQEKRVATNSPVIFRLTSMGPYKGNGFKVHFNEFRPTIPCYAQEFRCQEFQRCVHDDLACDGWDDCGDDSDEEEDAGCGLLTACEICAVIIGSVFIVASIAIIVVFVVTYRRRKLDYYANKNGSVWTPYTVQRSESKTPIAHDNYSLPDSTITFPRRYNSQESMSKSAFSRHTRRDSDNDSIDKLELEKSDRFSYNKTPDNMSEKSSRSAKNRGRLGDNRLGSTTKDPGSVNGYGSKERLSDRDKGRRDRSRDRYYRDRDYRRDDSDRDTPRSDDEDRDRDRGYRRRSSRERSRDRDYSYSDDSDYERERRRRRRRRRSYDRYSDEDSDSEYERERRRRRRSRDRYSRDRCDDRDRYDSDRDRKSEKDFDRESDRPRRRSSRERERHRDSYEDDRDKEKYSGDDSRDRKGFDDSSRGEKPGKDREDRERDQYYNTDKPDSRGGRRSAERKPYGDGEDVVSDRAQDRPTESQPSRYENRRSRSRENVRPARDEEIAPPPKSEELRQRAPADNYPRRPPAMNAAPTGNDANNSGTAEPVRTYRRRSSDERRGRRRSRGPQPSDEYAPPEYEDVAVLPELAGGYKEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVS5</accession>
    <name>A0ABM0JVS5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 53 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101856588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102675.1">
        <property type="nucleotide sequence ID" value="XM_005102618.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856588"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="10">
        <location>
            <begin position="41"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="11">
        <location>
            <begin position="702"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="811"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005102675.1"/>
        </source>
    </evidence>
    <sequence length="850" mass="96031" checksum="FBD61ED7205FAB79" modified="2025-10-08" version="1">MAAHEDDDFCDDQLESLLSFPPEVQEAIEQVLPSNDPLDKPDFNPVDYINTLFPTEQSLSNIDDIVGKIRHKIWNLDEEIRVVVRGQTNVGEEGRRALEEAQHAIQDLFTKIKDIKDKAEKSEEMVKEITRDIKQLDHAKRHLTSSITTLNHLHMLVGGVDSLTTLARRRQYGEAANLLQGVLNVLDHFEKYMEIQQIKLLADRVKHLQTELGTQIIADFEEAFQGVGAKYGPSNQKQLHDACLVVDILDPKVKRDLLNWFVKLQLSEYVVLFAEDQDVAWLDKIDRRYAWIKRALVDFEEKFGHLFPPDWEVSERICVEFCHLTRKELAKVMQRRQMELDVKLLLFAIQRTSNFETLIAKRFTGVTMQKSQAQTSSNAVMNKLEDSTNPFEEPSTNPFEQPGSENSNVPEDNKASQEAVSPFAGIISQCFEAHLNIYIENQDRNLAELINRFQVDIQTHGTPSMDGEENSNVLPSCADLFVFYKKCMVQCSQLSTGQPLIDLTKTFQKYLKEYAHRILLANLPKLSKESGTITSASGLIQSILKEGEVTKLTEEEQCRICSLLCTAEYCMDTTQQLEEKLREKVDAELKAAVDLSSEQDMFHTVISNCIQLLVQDLETACEPALTAMTKMPWSSIEAVGDQSGYVTAVTSHLKQNIPIIRDNLVSSRKYFTQFCVKFANSFIPKFVGTLYKCRPSNTVAAEQLLLDTHSLKTALLELPSLGSQMSRKAPASFTKIVVKGMTKAEMILKVVMSPQHPPQSFVDNFIRLLTDADINDFQRVLEMKGVRRGDQSSLVEMFRARVPVSSLLASTSHGGLATSPSGVSVSQQPATPEPESSRIRKLEKLIKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWC6</accession>
    <name>A0ABM0JWC6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division control protein 42 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103070.1">
        <property type="nucleotide sequence ID" value="XM_005103013.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849707"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005103070.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23863" checksum="EB2170F7AC159BFC" modified="2025-10-08" version="1">MENLSKLRSPRSLLAGPDKSVRCTVIGDGMVGKTCLATSFARRQFVEDYTATIYDVYCVPFCVGNDRYIINISDTAGQTDFDDVRSHVYQDTEVLLLCFSVRDRESFSSVIDSWYPEVRRLARRKCPVVLVGTQTDMRGKVPETETVTPAEAHRLAKKIGARLYVECSSKERHGLHSVFRNVLEIALRRRKRKNTMLRRFFRRSTAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXW0</accession>
    <name>A0ABM0JXW0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Uncharacterized protein LOC101857043 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24" type="primary">LOC101857043</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104117.1">
        <property type="nucleotide sequence ID" value="XM_005104060.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104120.1">
        <property type="nucleotide sequence ID" value="XM_005104063.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104122.1">
        <property type="nucleotide sequence ID" value="XM_005104065.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104124.1">
        <property type="nucleotide sequence ID" value="XM_005104067.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104126.1">
        <property type="nucleotide sequence ID" value="XM_005104069.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104127.1">
        <property type="nucleotide sequence ID" value="XM_005104070.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104128.1">
        <property type="nucleotide sequence ID" value="XM_005104071.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104129.1">
        <property type="nucleotide sequence ID" value="XM_005104072.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104130.1">
        <property type="nucleotide sequence ID" value="XM_005104073.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941201.1">
        <property type="nucleotide sequence ID" value="XM_013085747.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941202.1">
        <property type="nucleotide sequence ID" value="XM_013085748.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941204.1">
        <property type="nucleotide sequence ID" value="XM_013085750.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827135.1">
        <property type="nucleotide sequence ID" value="XM_035971242.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827136.1">
        <property type="nucleotide sequence ID" value="XM_035971243.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827137.1">
        <property type="nucleotide sequence ID" value="XM_035971244.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827138.1">
        <property type="nucleotide sequence ID" value="XM_035971245.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827139.1">
        <property type="nucleotide sequence ID" value="XM_035971246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857043"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16510">
        <property type="entry name" value="RING-HC_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="696"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="353"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005104117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005104120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005104122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005104124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005104126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005104127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005104128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005104129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005104130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012941201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012941202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_012941204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035827135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035827136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035827137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035827138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035827139.1"/>
        </source>
    </evidence>
    <sequence length="747" mass="81691" checksum="F9CEBE9273F68353" modified="2025-10-08" version="1">MTTNTVSRPRLQDTELQMKSPDVPARAHDSGELQQVPSPYKVNAAKLAVILESIVNENCLQSYEKLLEASSKSVKSKEDQNDSKRCHDIDTMFDMKFFKVKVPHAVVYHQRVDVPRSIGDIPWGSLKEEKCRLYTFSKYPLNASQSAILLAQDGFAYCGSGATSDDSVICYFCSASHKGWLVTDKIHDVHARLSPDCPMISHVNCNNVPMPVLQNGHALFDQLQSKDEKSVYSEPPKSSGNTEEIRTDSSLEVDQPESERRHVRGSHSHVSQYQNTEARAPAPVPKATQIATRSLMNQGHSKSNMSAQSSGNRRESNTVTAYQVSNANASFNVITSSNVVSSSGPVSSVAADAESGAQAASRSETNGTPQTTAAAAAGGNTSQATAATTATSSASRGTWVEDSSGSSTSNSRTPSSQPSSTPSDTTAGGEGQSTTTEQQGQTRPSAPQSNDSTGSTTQQQGAGPSYQQLGIITERPKRYEYALKVARLKSFESWPSGHHLTREELADAGFYYAGYDDCARCYYCGGGLRNWEVNNDVWVEHARWFPDCYFLRQMKGQAFINVVRRLSNDNTSQDEVAYDDVVREMDGTATGQTLGYLYTPGTRGDPLKWDAAVLAVTEMGFQKSDAIKAAKDLKSEGESMSADKLFKRLVETKKPRSQTELDPCESVSSEHSDSRVRETISSLKEQNSQLRQQTVCKICMDMEVSVVFFPCGHLVSCSECSLALTTCPVCHIDIWAFKQAFFFLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ24</accession>
    <name>A0ABM0JZ24_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005104908.1">
        <property type="nucleotide sequence ID" value="XM_005104851.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858653"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044968200" description="Peptidyl-prolyl cis-trans isomerase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="32"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005104908.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22756" checksum="B7817C4CC0E320CD" modified="2025-10-08" version="1">MLLSATVIVYALLNLVSVSDAAKGPKVTDKVFFDIKIGGKKAGRIEIGLFGKSVPDTVKNFKSLAIGFQKGGETLTYKGSKFHRVIKDFMIQGGDFTKGDGTGGLSIYGDRFKDENFKLKHYGAGWLSMANAGPDTNGSQFFITVKKTPWLDGRHVVFGKVVKGMSVVRKIENGNTDSRDKPQKEVIIADCGELPVDKPFTVEKEDATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ60</accession>
    <name>A0ABM0JZ60_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101853875</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104973.3">
        <property type="nucleotide sequence ID" value="XM_005104916.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853875"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF15">
        <property type="entry name" value="PROTEIN-ASSOCIATING WITH THE CARBOXYL-TERMINAL DOMAIN OF EZRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="749"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005104973.3"/>
        </source>
    </evidence>
    <sequence length="876" mass="95695" checksum="A4DE54C644AF475D" modified="2025-10-08" version="1">MGAENSVLEGCEWGDPVQAPPILPWQLTPVTKPDGSAASVFEPKNAEGKDGDLLRKAASTLKGIRHPNVVRFIECGDTSESFWLATESVSPLMTAVPDMSSAELCAGLYDLLQGLDFLHSKLGMCHNNLCLSSVYVAPDGVWKLGGLEHACSFKLATQDYLDKCRAFRVEDSLAPEEKASNVKADPALGHARDVFAFGVLVDALMDFVLEKDQTSQMLEQQLSLCVNSDPTSRPKVTALLGLPVFQNDLIDIVVFLKNITLKSDTEKKLFFCNLLSRLRHFSETVIVRRLVLLLLSRFVLLDEWADRMVLPQLLRPRLDSSEAPLKSAVETGVLSESMFQSHVIGHLYNVFHVHDSHIRLVLLQHFQHYVHLFSRQQLEVDIFLQVLIGLRDTDDKMVSASLRALADLVPILGGDFVIGGSRKPFFFHGLPKQVSPEELQQMEVPKNLNSIMSSHKPLLKDLASGGKSKPYTEMEKEKQSAERERKNREREQRREEARLKREERRRRLKEKQLEAKEGDVELQTSGKETLSQNGVGPPDFLTIEQMAKMDGDDQQLTALEKTKLDADLGTDRSKVADTDRSKVTYTDRSKVTDSDRSKVADSEDNDWSDLEEHIDDEIEAELSNMPSTVDGGSKVQTSPSPYRSHSPPSPPPVKVDWSDIPEADRGMGGPVHSALGGQKDGPLQLGHSLGNVKNSLSRSESDWGAEQRSPSAVDAGDWGDDSWGDSNTPSPVHAQSGSSPPPATSNKQSKSLKLVSAAKSNKSKTKTSSAATSAASAAGAGKKLASEDGLGIGYDIKSIEIVTKSVVVETDFFADMAPVLPEKSSKEIGGFPVGGSSVETGSPSVPKTKMFAVADAAEEVSVTISAGLSRNCDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZL2</accession>
    <name>A0ABM0JZL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">SOSS complex subunit B1-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC101857508</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105245.1">
        <property type="nucleotide sequence ID" value="XM_005105188.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105246.1">
        <property type="nucleotide sequence ID" value="XM_005105189.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105247.1">
        <property type="nucleotide sequence ID" value="XM_005105190.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857508"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005105247.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="23947" checksum="AC58DC75373425F9" modified="2025-10-08" version="1">MQMGERGKPAGDQSLFIVLKDVRPGMKNLHLMFIVLEVGKPTRTKEGHDVRSCKVADKSGSINLSVWDEASHAIQSGDICKFMRGYASLWKGGLTLYTGKIGEIVKVGEFCFNFAEMPNFSEPNPEYLKVEPPQRKSPTESGEGGPSQAKGDIQGSSSGVRPQLMQIQPGNGQGYNQQRPPARPPLSAPPRGIMNGNNNNNSNVAVGGAAGQSGRPSRGGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K052</accession>
    <name>A0ABM0K052_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Farnesoate epoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105632.1">
        <property type="nucleotide sequence ID" value="XM_005105575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846447"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005105632.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="60167" checksum="C00D292825EA1B50" modified="2025-10-08" version="1">MDAFQDTSTQWTLAVAAAVLCVLYVLSKQFVFRKGNPPPGPRGWWGFMEILQANRDDSLYEAAWGWAEKYGDMTFYTVLGQPVCVLNSTDIVRRLFSSDEYKMLTSDREPNVVSEFAWYNGKELFFTPYNSQTRQKRTLFHKMMGIYGEGVDKFESVVGKELDRVLEEMDIARATGQDVPMSQILAKSLKIILYILVNGDMGSEKVSYDVVDVLERYDTAVNQMLDVQTLTALSFFPALRKFGKYKKLCDEVRESRADAEKFLFENIKSTYEPGKVRGVADALLHFQGQPGHEWLDNEQIKGFLAFSFFAGQYSSRFAHMTSRSSLLNIVLTLTHHPEIARRIQEEIESVLGDRIPRVEDRMSMHYTEAVIIENLRYVSQLALSSMRTAREDIHIDGYVIPKGTQFPVNQWFFHRDPKIWDDPWKFKPERFLDDKGVVLPANHPVRKKVQAFGIGNRMCPGEAFARSRVFLFVVSILQKFDLLPPENEPLPSCDPRDNLKGVVRQAPPFKCRLRNRLDEEIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0B1</accession>
    <name>A0ABM0K0B1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein KIAA1143 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105734.1">
        <property type="nucleotide sequence ID" value="XM_005105677.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849790"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040219">
        <property type="entry name" value="KIAA1143-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195:SF2">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105734.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16710" checksum="21F6DF22464D48AD" modified="2025-10-08" version="1">MPRKGVQYVQNEEPSFIRQFKEKVGHKDGPDVNTKRQIPNFSDDEDEENVEEKEDEKPMVVVLKEGDLTAEEATSELKQIDEGPARLDEKITFKKPVKRTKEAAQDDEEEGKTEDIKKKKPSKDSKKKKENKSLLSFGDDEEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0I7</accession>
    <name>A0ABM0K0I7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein Hikeshi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105901.1">
        <property type="nucleotide sequence ID" value="XM_005105844.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849078"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="138"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105901.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21969" checksum="02DCDED2F347F7A8" modified="2025-10-08" version="1">MFGLIVSGRLVQTEFHSVSETQFLFNIPEADSINHVVVFMTGQTPFPDGLGGAVYFSWPRPEGPVWTMLGHISNQKPSAIFKISSLKSSDGSNNQVHFGAMAQQQSHQAQIGISVEQLDQIAQQTPATVANAPSVPAFVEFSTKMLESFFNYASSFAASHNQIAMSHSETFVPMSTLKNWFENFQRRLQQNPYFWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K253</accession>
    <name>A0ABM0K253_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101854196</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005106963.1">
        <property type="nucleotide sequence ID" value="XM_005106906.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854196"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005106963.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31053" checksum="7D5F1691CBE32A01" modified="2025-10-08" version="1">MALSMPKPVVKKISSSAASSLARRFAWEASSGTTECSVPVFWMREQRQCAAAFSENTELLNFTFCLDHAIPYWVVALPVLATCFAKIFISRRRSPGTGEIILERNSDAPGDSYSARLTNVQAKFSAKHSKLHPTRERKDAKKGSLGKRVFTPQGYVEPEQWDSDIEDGADVNTDGKPRRQRIYYLECPDYMMLRASAVTIFVTWLLWFPWVVARFVWNFTPYEDVPGWFEVLAVVCMHLSSFAKPVVYTLANPYFRGAVAKTVLCRRDMRLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K460</accession>
    <name>A0ABM0K460_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108336.2">
        <property type="nucleotide sequence ID" value="XM_005108279.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859131"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029371">
        <property type="entry name" value="TMEM101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31034">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31034:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15111">
        <property type="entry name" value="TMEM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005108336.2"/>
        </source>
    </evidence>
    <sequence length="251" mass="28888" checksum="A015D6AE2FF9C338" modified="2025-10-08" version="1">MANNKKIVCKILEFILHKYPLVNALTLLLLFAERAATNTDTPIHPRIVYANLLGFLGCALFMSSHIKRKEAALVFCGQLIYFAYNFYNNNKLHYKEWLRQEMCSRQVGCIGVYLLFAHIIDHKKSNLLRRLGEILLGIFMFAYVYLLNDSREIRRAFLSHMVGDDWARYVVAMVIAACALCFLSGYFVRDMALCAAVTIATLTLVIDCDFTYWSLKGVQFWNQGRMVADNLCICTGLLYAFFHVDNRVKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4I1</accession>
    <name>A0ABM0K4I1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101853584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005108561.2">
        <property type="nucleotide sequence ID" value="XM_005108504.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853584"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="757"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="1077"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="1262"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="920"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1489"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1578"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1949"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2629"/>
            <end position="2672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2802"/>
            <end position="2883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="838"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="921"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="966"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1492"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1586"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1636"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1958"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2629"/>
            <end position="2640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2659"/>
            <end position="2672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2819"/>
            <end position="2830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2856"/>
            <end position="2868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2869"/>
            <end position="2879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005108561.2"/>
        </source>
    </evidence>
    <sequence length="3162" mass="357390" checksum="1A59EA800E45869D" modified="2025-10-08" version="1">MGHVKIGRRFLVHVIVVFVVLSLVFSMILLREVQKAFERYSQFVDQMRRSDMLDADAELYVQNKHMLGRPLAELALLRSRRAHPISGVVVLTQTSYADNCIGFVWTKFHLNKIQKVSVVIANVRSPDRQAQHFSLRPNDTEFQECGFNKSTPYLVKLTAEGQNSGDVESGSEVMWTTQGIPPSPPPLRIISVTQTSITVEVPKIQLETGPLTAIEIRLKKGKTHEEAQSSRSKGNNPEVSLKRRKRDTKDNRLVRAERENVRKTFDRMLRTLLRNIAPAFSSLTNGHESPSADAELRLSAGEDGRKSSGKVGKREHLAGGSKDGYKDKRKSHEPDYRNDSVPGGERDKMAGVSVHGSNDDGIQDKNKSREEKGEKVRKYGGRNGGRGCEWFTKVSGTTDDLDDEAELKSIMECFLQNLQNFSNYVPNTLFTKSAKSSREENMFFNYKNRDNYIKNKSSTFSSHLTLPLYVESEGSSAKLDGKLEGEKSEEEAHGTVFLDFSQRQADSEKTQSVRRRRSVELDGAVWTSLGHFQEIPGISDSEERRMTLYGPEDLEFSQTEKLMDVVGRPPVLVRMGNGFFVSSPHGLRYPYFNDHRLLQNRLRSLKFTEVKDLVDFGYNHPEMSNLSWHELKSLQARLLALLERNRERWEKLYGKTVGWFLWELKEARSKRDVEVAKVAKLGLPPGYAVIRTQTPGPLNLTIGDSHDRGSLPNPPLEPNTEYEVVLVVLSTVADVTKHSWSSVNVTTLPTDPPSLSFLFTVLIGAFIAVIVFVILLSCFMLLCGRRHQRHSGDFQPRENSASYTKTSIASSDHDRIKTDIPSASDNACLLNRASVCPPHPPLPPPPPHAHPPFPQNATNPTPEGQPIRGPVQVSYPDKHSGIGSVPQTSVTPRSVLMVPRYNAAPVSVPKQSFLRKGYTVGTKTQTPNSSSSSLLFPAPRDSSSTYSAPETEDDNDYVIKMKNPDEESNTDSDDGYEEENHDEKNEKDEISEAEEEKGEEDYRASRNIGDSKEWPYQLLQSAPLDPERHWNRTYDVESKRFIVDKRENLGSDVTVSTVLRRYYSQDIPGSNGRPVTFREEFRLLNSRMDFSSNALVSELPVKNRFPHIPLYEHSRVTLGPDEAGNSSVIHANFITFNSDNSSDSSSSICQCPRYIAAMSPYDPETVLDFWRMIHQLRIEVVVMTTNVLEEGVVKCAQYWPRCGPSVKSFGHFLLQTVEEHEYSNYTVRKIMLGTKGSLSACREVTQFHFTGWPHHGVPEYPVPWLEMRRKVSTYHRDGPSPILVHCGTGVSRSAVYIGLDRLIRQYRKSGSVSVFKCVKEMRRNRPCMIRGVDQYVFLYDALLEEMGAGDTVVGTGERYRERRSHLCARNPWTGRSFLEDEFDLLNFFSLDLWSKFFQRSTNQVSLGENNRPTPTDNILINAKDDNFCAAFIDGHRQKDLMVLSSSAITRSEAWGFWNFVYHHNVRTLVQLNPNEFSGLAVQSDKVSGFEPRTQHDEPVQRDRSCNNVSSSDLDSVQFSGVRWEENGIVLTVKTLCEHRYHEIVVKDISLEVRRATGKKEVREVRLFSLVHNTETVSMTVDDKSNPRKTNKTKAKREKKVRQQNGRVGKRRQRRRRTSKVGSRDIPNLMQGLGGPTATSPNSHQANHSEISPIYLQTFTPQTPNQSYWLPVTPELMNPCYWSSWTPQPADPNHLQYSTPQNLSTYPHYSQSLNPQSASPGFWISVNPQSINPDHCQSLNLQAYHPYTWQSLNPQSSNPKTWQSLDLQFFKPDTRQAVNPQSSNPDVPGSCCPDVQGYLPSVNCFWEKGQAVNCSHARSKWCSQDSDQKLHCSGAPLPSSYSSQNQPSPCPLHSVGQVTVGFFPHPDDQMTPFQAPATRQYDLPDNMKGYHTMSDQVSALSEERKNGDAVDNISRTKIHRPDCLYREQNLNLNPSPHPATNLVFSVNREPENSKHRRLTAQQNTQSKPGGSDRKQEMLSTILENSMNTVQVRLPETLAQRGIRLKQPLGNFEKVNTVNGGSIQKHSLIKPLTKAEGTVTVEREPQNNPEQPRISTAQNLLERSPQPVNWSDAITQKGNRSILQQEVHLKEAEQYVLKNDGTIREQELMIPTQERQQKHPEQPSITVKEPLTHSTELPRTSKQLVFKPGYQDNNFMRKREESLEHKIEPKTLHGSVRIPELRASKILNNPVIKSESYTVTSNIPTSENINSSSTGKRELLEEQICEIETVNLEKSFTPSETESLPEQIGGIIETPPFINGTLDEQAENTVQSPLIQSKTKYGQQFFKVEKALVDKKISPLEAYEESMRNPTLCISEAGESRSRKNSVCTIVPTQLMDGHFIDESGLGKPVSPEQYSDPVEEFHADFFTTSSETSSTPEHTTSVFKPKIPDEIAAVSDSPSVANDVIQLVSHFSPVLENDRKAEVKMSRGNKTLQNFPCSDSPVFNKIRNGFEQTNTNIKEPKFSKPSYCPGQLSPQQDVSLLTTLDFLCENTCNSAVSPSWNSDSKYQRKFLNNSKRWRDRNAKQKTATSGDKARQKLLFRCQQLTNRHCKDRNKHRAGTGIAHKTCSMVKVGITENTAKRLEDINCSNAVQAPKRKGIRQSSSPFVMTPDLLLRLQELVMDWQTAPSQLQLQQQQQHQQQQQHHHHQQQPHQQLKIPRFSDQSPESRTSVRNTTTVAAAAHNSCSPTHYTCSSAHYSHRPAHSPILIQYDKAESPASAASLLFCAVVLMCEKVQEDGEVDVYHTVKYLRSKEPSAVRDMAEYRLLYDCLDLYMSDYMCHVTNTDRWKLRPAIDLSYRPVNLQALTSQMKNTTSRREDPKTGTGTRPPGTLRPLDDEGNASRNGSRDTRVGYQRKTKCSVDGRNPQREENLNISHLSQSEDGFQKKQHSTVIEMDLESKRFLRKSCHTETCRNPRTRARYDKIEGANRRIESNPLNNIQNFHNLGKSRVCYRRGDANADDVNTTRSCVFSSGSFLKGGDSYRKPCSVQKRNGRTSVTDTKCSSFPKEEKSITESHTTSMIWSQSAQGPKPHHLAVTADNVTDNHNDIVLRGEDVGDKMETKLLLNINKSTTCINNDERNERCFGRERLKEDYKSSSDLVDNEICSRSKLSKNIENAGYEDESDGGAESLASSDVHLLAGEASVRCIEELARSMNRDRRLDTAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4S8</accession>
    <name>A0ABM0K4S8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter ZIP11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 39 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Zrt- and Irt-like protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101853495</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108739.1">
        <property type="nucleotide sequence ID" value="XM_005108682.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853495"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF211">
        <property type="entry name" value="ZINC TRANSPORTER ZIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005108739.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="35892" checksum="7026166942C37989" modified="2025-10-08" version="1">MIESAHPLLQTLLGTLFTWGLTALGAGLVFVFQSGQRKILDGSLGFAAGVMTAASYWSLLAPAIEMAEGSGLYGSEGQWAFVPVAIGFTLGAVFVYGADVLLPSSGNMLNPSSSLALSVEDRPKYEGSESILLTVQEDMVGSSGAKPRLNQADTRQRRTAGSPSALDARYHEKNGLSSAPARLENSDSKAVSWRRILLLIIAITIHNIPEGLAVGVGFGAVGKTKAATFENARNLAFGIGIQNFPEGLAVSLPLRGSGMSTMKSFWYGQLSGMVEPIAGLLGAFAVFVAEPILPYALAFAAGAMIYVVVDDIIPEAQTSGNGKLASWGAVVGFVIMMSLDVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K755</accession>
    <name>A0ABM0K755_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium/iodide cotransporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101848697</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110332.1">
        <property type="nucleotide sequence ID" value="XM_005110275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848697"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005110332.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11515" checksum="5B98BB3168DB88AC" modified="2025-10-08" version="1">MDILSSAGNYLVGGRKMTFLPVAISLMVSFESSIMMLGLPAEIYCYGMEWMWYTVGVFVAQVWYMGIVLFGPAVALEAVQGTIDSGGPKRVVDIANEGGRFKMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7J7</accession>
    <name>A0ABM0K7J7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tectonic-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tectonic family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110618.2">
        <property type="nucleotide sequence ID" value="XM_005110561.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860055"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040354">
        <property type="entry name" value="TCTN1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011677">
        <property type="entry name" value="TCTN1-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057724">
        <property type="entry name" value="TCTN1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611:SF2">
        <property type="entry name" value="TECTONIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611">
        <property type="entry name" value="TECTONIC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25752">
        <property type="entry name" value="DUF1619_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07773">
        <property type="entry name" value="TCTN_DUF1619"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045035161" evidence="6">
        <location>
            <begin position="28"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3 N-terminal" evidence="8">
        <location>
            <begin position="88"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="7">
        <location>
            <begin position="210"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="7">
        <location>
            <begin position="419"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005110618.2"/>
        </source>
    </evidence>
    <sequence length="685" mass="73826" checksum="274029F92D158796" modified="2025-10-08" version="1">MAARRLNLPKLGLAVCVYGCLLHIASSQNTTTLPVTTDNATSAANDTNTTSAAPTTTPTTTSTTTPPPTTTVFLLPTMSESPVPENTDVSLCPCDLTGNACNVNCRCDPDCSQADIDVFEPLPASALNPVDNRQCFSQNVFLFNNGPGTSEDRDDGLFCIFYDNDESRNYYVNPTLISSEAELLQYSADYSTFSFQSTAPPTLTAQFNDYYKSGDPLYVVYPTQAFGYLGLPAALSSSPVCTDGNPAAYHIEAENKCARFFTNLATECQTDVALRASTFYQNFTIVRDPYLLKAFNSSVGGDEKGIYDLTGVTELYTNNYTLTFDLEPTDPLLCVVGGVTGPCAFATPPAMPTYDAASATCRNVLTEVRYRFQTRGRFGIDNAYVSFVFSDITDNSLTQTFSTSFSTASTSTEAPVARSGNPGYDVGLPVLAGISNLTSTGGYYIQRTPLGLVRPSVTGDCLTAAGQPREPVLFGEDMRTGCFIQVSASGIDQSCRLLQQEVISALEGFPATIDTDINEYSKTSLVLAMFGNSEPEKTDDWPPVFYSSNRPRPPTSSGSKCLLSLGMNLQILYANVGSLANPQPMIIGAAFVYDEPQQVEYQCSGPFCLPGSSAVTQRVEISSSVTFIDVSRLPEGVEGVYPTFAIRLPYDFFYPFLSSAPASQGPCGYLSLCVCLFIAMTQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8L0</accession>
    <name>A0ABM0K8L0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101853044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111388.1">
        <property type="nucleotide sequence ID" value="XM_005111331.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853044"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005111388.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22162" checksum="9ACD2AC321420733" modified="2025-10-08" version="1">MAMRPRGYGFSSEISRKIAAKYDTTLEQEARLWMEAVLEQPLMPGANPNEPLGVDQFQAALKDGIILCNLLNKIKPGAIKKTNTSKMPFLQMENISKFLEGCEALGVSKTDLFQTVDLFDKVNMVQVINGIYALGRKAQKIGYPGPTLGAKEADSNPRNFSAEKLNAGQGVIGLQMGTNKGASQTGMSFGRSRSINEHGQNGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8U1</accession>
    <name>A0ABM0K8U1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111566.2">
        <property type="nucleotide sequence ID" value="XM_005111509.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852370"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005111566.2"/>
        </source>
    </evidence>
    <sequence length="361" mass="41678" checksum="C02A9AAC2E3C4E58" modified="2025-10-08" version="1">MACKVKDSKGPDINRPNNPPITYGPGEETTLETRKGSPTSDFHEGSAGSERGSKRHSTTNGELSNNQDNVDSHSELSEENQMFLNDDDEEEDGFHGGGPNGQNYLFSTYGFNPGRSPIPLETRIRRAKIVQEILAQFDLESVMNRYRGNVINGSYSRSLRTRLYDQWLSDTMGNKRGPDSDREWNERFQKKIMEDYERKQAEQERRLAEAELKRVLHLKLQGVMPAHDKTRDGQKEQKQSKAEKRFERQTAKSHQSLYRKPNDIETQMEILRRDESEVKSRRKNTENDNVICQENGENSEDSDNKNSSEENSESNDQRSHSGRSKAERLVANPELDDLYEEEDLEQLYREAEKLVRITSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB27</accession>
    <name>A0ABM0KB27_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC101848334 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101848334</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005113309.1">
        <property type="nucleotide sequence ID" value="XM_005113252.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848334"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040546">
        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF35">
        <property type="entry name" value="LD08718P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="659"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="843"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="914"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1102"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1181"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1245"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1272"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="978"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1245"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1307"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1317"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005113309.1"/>
        </source>
    </evidence>
    <sequence length="1429" mass="157064" checksum="EC9D5578EB687E23" modified="2025-10-08" version="1">MAPTSLIIPSVVDRCRLRLVRDSVEELFNVSTSTISSAVPLLDEDEPKRYYDSESEVEQFITGQTVGVQSLVVEGNSLITEVDKSERRNCEHVATVPNSDISDSSVTQGQEDPVSTLCFQTDGPQENIEKAQTFARAHLLLNKEDYIIRSQCLSSKQEFEMVQQCSRDLQTSTLALLTFSPEKFEVSYQGSEDSVKDAESHVECILSKLRGDGETILDKQEQENIENEKLNVQRANRKDIMAPAVSESSSGLCERNSDASRKSVSVMGSGTSEDSTNGEEISNRDYHLGVCQENTSSALRISDSLKSSGSVSVSSFSSTCSSDEESGEEDNVLTDLRYSKQVEQAVKLGYSEQHVKKALSKLGLDCGLDDLLRELITIGAEEKDVAVISSSDGNQCEAGKPDPGALLGFSSTSTSGPGDVSGISAKDSVQRNSSFDYNDSSNLRQIIIDGSNVAMSHGKTVFSCKGIKLAVDWFRERGHKDIIAFVPQWRKETSRPDAPITDQEILTELEKERVVVFTPSRRIKGKRVVCYDDRYVLKLALDTEGIVVSNDIYRDLCSENEDFRKVVEQRLLMYSFADDRFMPPEDPYGRGGISLDNLLRKVPMQLAFKPQECPYGRKCTYGNKCRFFHPERGYTPQRSVTEALKEQAEHTMLEIKERAAEKGRRPKQKLVRTKSFVPETRPLNPSAFDGDAQKPKLNHSKSLVALSPKSADYLNEPRRKMESELSAAFEKMPLKQRHSASSMGSSFFSTPKDLGKPQSVFEDPVPQANSPRSSPLPEREVVKQFGAGGAAVPASSSPMKNVVSVSQRASPSHLTVPKHEQSEPYLSGHLLVAKKLSDEGKNDFFSEHVSSPSSTRTSSPVVPLGKGGEQRNLGMSDSLSRESLLDASSAHPHGAFSNTTENLPNLSLFHSGEATSLSQSSLPGSSSEDRASLEMLQRAGSDMYPPHSGTFQEDDNLPELSIFHRSGDASGMSSPSSRTFSSAGNLRQHNDESSRCQDFATSPNVFSPVIDSGNFSGSETQPSPVTSRQSYFQKMSGEPGTSEPPSLRRAFSSTGNVFGSAVSSEGQHVSGPHTGRLSEHLTLKPQHSVPLGQKPQLRRQSNHFEFSRQNSSSDPQIHQHSYGVGGRDVSDQLPVGLSPYPGGDRSPGPGMFSPQAAVELGSNALPLPQQQQQQQFYYPPQQHLQRSLQPQHTDSQSRRAVHRQSVSEVVWGEPVLGMYPPVSSGLHRTPYPLNCVDGGVKTASLTPYPQSTSDLSAYSQQQHPARASFPLPMQQYGHAPLPSSHFRQQLPPHQLTHSQPPFMPHSNPAAPFSFPNPSQPPPPPQTGYPPPYHSSSSGYAIPPDMSSAVSSPYFQPMHTQAPPPNVMPTIHPEDTPILQCDQERYLLYHRLIPLFGEAAVRKVMNKHPRILNPEDLCPLIIAFKQETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV82</accession>
    <name>A0ABM0ZV82_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859313</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935157.2">
        <property type="nucleotide sequence ID" value="XM_013079703.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859313"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534:SF1">
        <property type="entry name" value="IGGFC-BINDING PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534">
        <property type="entry name" value="IGGFC_BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046410796" evidence="1">
        <location>
            <begin position="30"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="531"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935157.2"/>
        </source>
    </evidence>
    <sequence length="609" mass="66146" checksum="A436991B78F2A6B4" modified="2025-10-08" version="1">MLCSYAPVQSPLQVVCVVFLHLLVSGIQGHAGTEFFLALPQNDQSNTASFITLTPEDATAASITVQIRGGNPSQGEVVDKTLQLANGTASRYHLPVSMPMPLGCVVITGHALLVTSSGPINIVVWSEGKSNSEAYLALPVTQLGTDYFVFAYPGSAGEKPPAAGFLLVTGVSPDTQLTIQLPQISVPENEFVFFQGKYYGPGDVISATLNEADVLQIQSIFDLTGTHVKGSSPIGVWSGVNRTAHQSQCRSHMVETSPPTQTFGREFVLLVLPYTLPSEEFRVLSRGWSTQVTVNTDDGVSPTVHYLPRPGSYVRISATNLSTYMSLTADKDVAVTRIIPDGSEDADFSMTTILPTDKATNKEYRFGWYDHHNNEEVLLSYAIRSSDKATLQLNGHPLVTTKGPFWSNIREFPVVNWPDWMVALVSVNVTSDLVEYELKQTNGLPFTAYASAAKKCEAEGYPLGYPDVASMSVSPDLPEVPVSGQCCHDTDLTGNTMVDLHCPITWPPGEQCCVNNNVYKTCTIQNMETSCQRLSRYRLSDSPETVSASTVLECYTTCRTSSGCFGINYSETDDVNTRCELLMGTPGGFITNGSWLYSVCSSKMSLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVM0</accession>
    <name>A0ABM0ZVM0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Clathrin coat assembly protein AP180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106011208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935469.1">
        <property type="nucleotide sequence ID" value="XM_013080015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011208"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
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            <dbReference type="RefSeq" id="XP_012935469.1"/>
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</entry>
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    <accession>A0ABM0ZVZ8</accession>
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        <scope>IDENTIFICATION</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="entry name" value="PROTEIN SCARLET"/>
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            <begin position="109"/>
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            <begin position="324"/>
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            <begin position="92"/>
            <end position="200"/>
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    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
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            <begin position="210"/>
            <end position="273"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="Proteomes" id="UP000694888"/>
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    <sequence length="351" mass="40202" checksum="F0B3E23BDCF02362" modified="2025-10-08" version="1">MGKSDEAFDFFNRLNYPCPRNFNPADHYILTLAIVPGKEEECRRKTNAICDTFTESPQARHIDSEIDLRLRESELADHIVVSDTYASSLWVQVKNLFWRSWIAQFRDAMLFWVRIGQSLAIGLVLGLVYLQLDVDQKGVQNINGAIYLLILNVTFTNVFAVLTSFPEEMGIVMRELGTGLYRVDIYYIAKIVTEVRAKVLACYCYRQRVLWYVISVITGDTTLALSLTSPVLVPFLLFGGVFLNGDDTPVYFVWLEGVSWFKYSNELMMVNQWEKEEYIECENKTISPNRTQKEICQALTCQFTSGADVLEYNSMDADDVGSDYAALCGIMFVFYLFAFIALSIRARRSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY20</accession>
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        <submittedName>
            <fullName evidence="13">Myosin-10 isoform X1</fullName>
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        <name evidence="13" type="primary">LOC100533391</name>
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        <name type="scientific">Aplysia californica</name>
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            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
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        <property type="component" value="Unplaced"/>
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    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
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        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
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        <property type="entry name" value="Myosin_tail_1"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="IQ"/>
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    </dbReference>
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        <property type="entry name" value="MYOSIN_MOTOR"/>
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    </dbReference>
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        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <begin position="35"/>
            <end position="85"/>
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    </feature>
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            <begin position="89"/>
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        </location>
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            <begin position="683"/>
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            <begin position="1114"/>
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    </feature>
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    </feature>
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            <begin position="1362"/>
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        </location>
    </feature>
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            <begin position="1431"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <begin position="1881"/>
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    </feature>
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            <begin position="1974"/>
            <end position="1991"/>
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    </feature>
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            <begin position="1992"/>
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        </location>
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            <begin position="182"/>
            <end position="189"/>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51844"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012936858.1"/>
        </source>
    </evidence>
    <sequence length="2008" mass="231289" checksum="364EAEB2C14F5CE4" modified="2025-10-08" version="1">MADFDGASGLSAIELSYLAIDRSIINDPAVQAEWASKKLVWVPDENNGFVAASIKAEKGDQVECVVDETGRKMLVHRDDVQKMNPPKFNKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKVIELYKGKKRHEVPPHVFAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAYVAASNRTNRQSVSSLQVPQDGGKNVDALKQNKDFNLGELENQLLQANPILEAFGNAKTIKNDNSSRFGKFIRINFDSSGYISGANIETYLLEKSRSVRQAESERAFHIFYQFLLGASAAQRQEFLLEDMSKYRYMTSGKMLVTNVDDAHEFQNLVSSMSIMGISPDDLSAVLRTVSAVLLFGNMQFKQERNSDQATLPDNTVAQKACHLLGVPVTALTQAFLKPKIKVGRDFVTKAQTKAQVEFAVEAISKALYERLFKWVVMRINKSLDRTKRQGASFIGILDIAGFEIFKSKDKMNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLLEKPMGILALLDEECWFPKATDKTFVEKLLAQHTTHPKFEKPDFRADADFSLIHYADKVDYSADQWLMKNMDPLNENVVSILSASTDPFVVNMWKDADIVGMGAAAAVDTMFGSRTRKGMFRTVSQLYKEQLAKLMMTLRNTNPNFVRCIIPNHEKKAGKIESTLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPAAIPRGFMDGKKAVEKMISVLELDSNLFRIGQSKIFFRAGVLAHLEEERDLKLTDIIVQFQALARGLLARRNYQKRLQQINAIRVIQRNCAAYLKLRNWQWWRLFTKVKPLLSVTGQEEKLHTKEEELKKVKDSFDKQKQETEEMERRYAQIIEEKNILAEQLQAETELCAEAEESRARLNKRKEELEDILHELEMRIEEEEDLNNKFMDEKKMFTQNIKDLEEQLEEEEQTRQKLQLEKVTAEGKMKKLEEAAAILEDSNQKLVKEKKLMEERLGEAQLNMAEEEEKSKQLGKLKNKYEAIIADLEERLRKEQQARQELEKIRRRLETELTDLRDQLNEKRQQVEDLQAQLAKREEEVQSALRKADDEEVSKSSFQKQMREVTNQLQEVMDDLETEKEARNKAEKQKRDLNEELEALRGELEDSLDTTAAVQELRNKREHEVQELKRMVESAQKAHEEGVQETKQKYNQQVEQVSEELENVKKTKASLEKAKATLEAETTDLANDLKSVQMAKQESERKRKQAESQVAEMSLKLAELERTAGDSGEKSKKLQVEVEQVASQLEAAETKALQGQQKASSLEAQLADVQDTLQEETRQKLALQSKLRAAQDDKERLEERVEEEEENKRQYEKQMQEISQKLIEVKKKADEDMANNEALEEYKKKVAREMEQLQQQLEESRIQSDRLEKSKRKLQAEVDDMTVELESQRSNVSNMDKKQRKFDQMLAEEKSVSERLGLERDTAEKESREKETKILNLQRLLDELQERADQLDRAKQQQARELEDLISSKDDVGKNVHDLEKSKRSLDATVAEQRQQIEDLEDELQAAEDAKLRLEVNMQALRAQFERDAAGREDQEEEARKSLLKQLREMEAELEDERKQKAIAVNARNKLQGDLSGLEQQVEMANKVKDDAVKQYKRLAAQLKDFQRELDDSRISREEMAGAMKDNEKKVKNLEAELLRLQEELASAERAKRNAESERDEMADEIGSSSSSKQALLDEKRRLEARISELEDELEDEHTNTELMNDKARKAQLQAEQMAAELASERSVSQKLENQRLALERQNKEMKEKLSELEGQSRARTKATIAALEGKIANLEEQLDQEAKERSSLARANRKMEKRSKELALQVEDERRSADQYKDQLDKSNNRVKALKRQLDEAEEEVTRANGQKRKLQRDLDEQMEVNENMTREMATLRKYSVGTSVNDTNNCLFPGGWRALWPSASRSARSVMSTTLRGSDTTLDDQGSEDGNEDQSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYN8</accession>
    <name>A0ABM0ZYN8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101859932</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937270.2">
        <property type="nucleotide sequence ID" value="XM_013081816.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859932"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937270.2"/>
        </source>
    </evidence>
    <sequence length="353" mass="38440" checksum="B1040A01AE3505C5" modified="2025-10-08" version="1">MFGKDSDDAEIYYSTTSEQLRELERTSSIGTTSESGRNSATSTQELYISANDVRANKRKNPSKRVRINSTPDFLEEHGAEYTSAFQVREQKRQSKKLQSEAEGGAKSDNPGNCDEEGDKNASEAEGYARLGQDSSILEHVIMASYDQLAPQTEGQDDYSSVPDGGGSRPDSLRSLVESESPSAPASSGLVNQAFEHTDGKGRDEDSAVVMRLAANQTADDKGLYFELEKHRSSRMSSDYSDHDTRYSTAAETKVDLNLPPKAKGKRSVTSEEISYEPIYNDAKSEVSASRISAPVTMKSRGEDEKADPHRLSAPSVVGTTKASPPVAAPRRKASNSVRASNDCFQYDLAKPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYQ0</accession>
    <name>A0ABM0ZYQ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC106011610</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106011610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937284.1">
        <property type="nucleotide sequence ID" value="XM_013081830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011610"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012937284.1"/>
        </source>
    </evidence>
    <sequence length="719" mass="79621" checksum="3542D0AC76839B65" modified="2025-10-08" version="1">MRRASALVSAVCLTYIAVVSVIQLSLLTTPTRTDNRYLAIEDASGKTTAPPAPNSRHDGEKFKINSGGRENVEEEKDRPGHALNTAAAPRRRYDSAKQFSDADVTSAASDMRHGGSIDSVLLRKLSENKRPSAESPAFSTGGSDLYQVDNPAAVAPPGGTPYVVNPGHPPPAHADTDDVVAASYIRESRVIFRPLSDLHVYAAYLDDRLAPQIYVRIFALRPSGNDTPAVVCRFPTKAAGGATQEEEEEDGEEGGGGRARGRRVISVTARAYEMCENHGKKYGGWIYSCLLPPPGVIRTPPAAVTIATVSDSGQTYDVIQAMPLKSLTPQNNTTESNEYQTAFPWDSSDKNRRDSLKKNLDFSDKNIPAGFRGRQKITRDAPNTQLQPPVSSRDERTFQNNSSNFSPPAGHTANTTTTNNNNSSNNDNNFHNNNNFNNNNNATIGVCVPPLFGDISLQRIVNFLEMCRLLQASRVFLYIHDLPKDLVVFLRHFASNHAHFLSLVQWELPKLPELWLDQSPSLASQMLWNRGQLLAVQHCLYQHMPAFDWLLFMDTDEMLVPHAAASWPDLVRQVLADAQPQVAHADSVAAISFQSAFFQQDFQTLVTNSIDYFQYLHRTRDTSSRRSKLMVRPSRAFEVGIHHLSKPIAEPFRSVAAPVSSALLHHYRKCVTGSVQGEGERIQCEILVKDVAILKYEHELTVRSRTVLQDAMEFFAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ68</accession>
    <name>A0ABM0ZZ68_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937539.1">
        <property type="nucleotide sequence ID" value="XM_013082085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011665"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937539.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="21491" checksum="FED3A0C9EF7CD293" modified="2025-10-08" version="1">MSSEVPDVDSASGSKPSLTSQVSTGRETTVSMLSSESTDDILAKYRSPKKAPSGKVANNNSSSAVNNNNTNGSSGGSGAEKPGDMGPADSASGSRGAGGQTSGVNSTAALVGIMSRGGSISDSHHPQEDNGPPFFDPDNLEGCPAFEDAKRKLRMVLSTGDIYVGLNQVQSSSPREGAGAGENQLLNLLQAQMAEAINLQNKDVVAQLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A140</accession>
    <name>A0ABM1A140_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall protein DAN4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106011940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938689.1">
        <property type="nucleotide sequence ID" value="XM_013083235.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011940"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045430320" evidence="3">
        <location>
            <begin position="28"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938689.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="54913" checksum="EBE59CC01D17B629" modified="2025-10-08" version="1">MSSYVDTLMTSLLVCVLALTLTCPVRSTTTTIPAAATTETATTTTATTTIAITTATPTHTTDAVVSETGGGDMVPAGNTTDIPRDLSTTTTPRDTLTTTPRYMSSTTASRDLSTSTSRDTPTSTSRDIFTTTPLDTTTSTSRDIFTTTTTSRDRNRPPAPIPAPTQTHVTSHHSAAPHANTSGSQHTAPGRFEPGPTAAGASTVTSSAAAPPPGVRGTTTTTTATSEEAMDTRATSPGVRDITTTTSVSKARGTQVGSPALPLGDPVPTDGWKDTTSSDPLEDASRLHGNATGEGDASRLHGNATGEGDASRLHGNATGEGDASRLHGNDTDWEDAPRLPGNATDVRVGESRDPDAALFNTTVSWNTEGTGSDPRSSRAVNEDLGGSDGMSSDSTTGRRTGVGLGFVVGTRGSSPARGEGGGEDETTTTAGVGGESEGGVKEGEHRGEVRVRESETRGFEVSYSTPAGLRIVGTMVMLGVLAMAGLLLCSCSIYRQWRADRVKGHVGGGKEGEGEVEEMAALTKYSKDGGRGEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1B2</accession>
    <name>A0ABM1A1B2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852025</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938814.1">
        <property type="nucleotide sequence ID" value="XM_013083360.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852025"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938814.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26855" checksum="CECED05D002EA149" modified="2025-10-08" version="1">MSAVPRARTSYDYYGDQLKEDYFEDMKDYIPIQGRQTPIGMVRPSSPGGPRLSVERQSRPRTRSDRPGLGPRSRTQIDYGQIEVDENPYSKPMDPINKQYYYKKWRNQPPQPQPPIYREGRLGSPWRHIKACINNAGNHLVFIDGTIKSEENFFYPPESMFEPPNFSMYISPRMPRRSLTQVPQTYRGDSRGSSFNERARQGFQYWYHQKKPIDCEYILTSFISFLGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2X0</accession>
    <name>A0ABM1A2X0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-hexosaminidase</fullName>
            <ecNumber evidence="6">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101846147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="6"/>
    <dbReference type="RefSeq" id="XP_012939749.1">
        <property type="nucleotide sequence ID" value="XM_013084295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846147"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="66"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012939749.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="61425" checksum="4DC8DDB7E8805BF3" modified="2025-10-08" version="1">MGATCPGYPQHGMNEEYNLTVDTEIHIATFSVWGLVRGLETLQQLMYTVQGKWYINAARIEDAPRFSYRGMLLDTARHFYPVEILKKNLDAMATHKYNVFHWHIVDAQSFPYRSIKFPDLAEKGAFSPKLTYSQEDVQDIIEYARYRGIRVLPEFDTPGHAHSWGIAMPELLTPCWAGGEPGQANYSYHAERENFDPSKNSTFQFLEEFFHEIKDVFKDEFFHMGMDEAHYMCWESSPDIAAFMEASGFGHDFYRLEEYYNVRLLDIVQRLMRKSIIYEDPINHGVTVPNDTIIQAWKDVTLDPHLQPWQSYVEQLLTTTDYHVILSSCWYLNKIYSNQDWRRFYACDPASVNATDEQLSRILGGEACVWSEYLDEYNVLQSVWPRASAVAERLWSPANVTDVDDAQLRLDQHRCRLLRQGIPARPVLAGYCLDDYNIDNSRSHLYPTPSTLAPHDTTQSENTPTSSTEEGDAPFPSSTSTTAKGDNSKDRRSNTNNNNKKSGHNGSNGRVTAPFTLAITSIVVAVCLFKGWCGLGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4A9</accession>
    <name>A0ABM1A4A9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC101855353</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101855353</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940560.2">
        <property type="nucleotide sequence ID" value="XM_013085106.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855353"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012940560.2"/>
        </source>
    </evidence>
    <sequence length="534" mass="58662" checksum="F191814CBE3B6235" modified="2025-10-08" version="1">MATSPFACIFHFSCLIFGGVGMQVALALAIVDRYVAIVYPLRYATIVTYNVVCACVIGIHSFIGAFSFAPLLPGFNNWWKTCTCTFNLVLSTGYLYTLVSLIMISMVVSMTLYSKVLHVARRHQHRIHAVVSQQPTSEGRAVGVSSRGTPHTGVRTLQENLQFEGRERNISGRTKNNVPQTTENNVQFGEGKKQFNSFPNARLGSEQLVLASEPQFELKKDGSLSHTHQESGEVSERRYSHDSTHGEDNRVVCQSPRQLTLACSGWSVISRGDPDRAGDEVSNRSVSGSCTSPPGFHCPRAGQIVVKCDQLYTNDNICLGTPRRGMSLLTREQSGDKSDLVRTDPAREAESSHPGSALQTLTSRVGNDGQGFPDAGQNQGPLLECRIKFTQSSMDKYSSKQSRNSSQDQHKSRSPHLPNYESAYEDHMEVSEKSQGDTTYVSSEQTHCVPIPFIQADSQHTKVEHPGNAESKQVRNVPLALQFHQKVMGVSSVLRQTTGSGHSFAPYDTSSPVSAQTSTNQAQDRTNLAQETIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4H0</accession>
    <name>A0ABM1A4H0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Receptor-type tyrosine-protein phosphatase eta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101845017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 14">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940671.1">
        <property type="nucleotide sequence ID" value="XM_013085217.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845017"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046181782" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="736"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="889"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012940671.1"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115389" checksum="9EA7027832E366E3" modified="2025-10-08" version="1">MATRIILFLVLLLLISAVLPALGTNETLTSASPLNDVQGEDRSGKNTSTRPTSSDPGCDAVSKRSITQMDVKLSGRQIFTVSWAENECPSNWTDTCTIVGTESNDNSTCRNKEAGQPLKPATKYTITIKRVINDIPKKTNLIDREKCTGMNPIENATIRLTQQERLRFTWENDCKWCTFKCFLYFGEKSTETKGTQMNCEFDEFPYGAVYNLTIQGNGTGECRNASTSKQISNVTASTKPEPVTNVSAEAHGDGLKVTWSLNGKYPGPVSFSVTVKDVLTGNSQQIFCPKAKVNDNSQWKNHTGMHCIVEKLKAFWLYSAQVKAKTSEGFSISKLSKRCLTEEGVPSPVNFTATLSDKNSKVVVRFSELAPIERRQPVRFYFVNKTLDTRKGDLDYCEKEVRPFKFSQEHSKLPTVDEDDLDSVYAYLKDTELRNHSKTFDVLPGCIYKFTVTTGRDQTSGGNKAFNTQSISVPIRKPRPWNVAKDGPLVKESNSKPTKNSLTFLASSDFFKKSSSGPIASTGFVVSRIRVKAGTTNIKTLKSYSVNRDKFRVDYSAASSGMVSSGTKVFVRVSIGSNTKKDECLNSKNSQNFKCNGPLRKGTTYHVNGFACTTAGCREAHLYTGQTADEDVQEEKLKNAIIGSSVAVVLVIIIAVLVVALFYRSMKRETAEITNRSPTQFQLKPFPNLSKPIVLAEIEKVVKEMSKDSGMAFMNEFGGRIASIPIRPFYKDCVTEKNRYEDIKPYADSIVLLSEQNGDPATTYINANFIPGYNDEREYIATQAPLPNTVADMWRLIWERDISIIVMLTAIREGKTNKCEQYWPEVRGTKSQYGDIHVRNISVSSINNYNITIFSLTHDKVDGVVKEVKHFHLLTWSDHSANVPPPCLVQFAADVRSHVTPHTNKPVLVHCSAGVGRTGTFLAIDYLNQFLQERRLDEEVDILAYVTSMRKHRIFMVQVEKQYALIHECAAFMMQRRRKQEEEEGVGVGEEGMGEKKEEKTKEDEAIIINDSDNQVLVQSEVTSSDTAETRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A678</accession>
    <name>A0ABM1A678_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Uncharacterized protein LOC101858879 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10" type="primary">LOC101858879</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941594.1">
        <property type="nucleotide sequence ID" value="XM_013086140.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941595.1">
        <property type="nucleotide sequence ID" value="XM_013086141.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941596.1">
        <property type="nucleotide sequence ID" value="XM_013086142.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941597.1">
        <property type="nucleotide sequence ID" value="XM_013086143.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827347.1">
        <property type="nucleotide sequence ID" value="XM_035971454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858879"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF32">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="535"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="448"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012941594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012941595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012941596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012941597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035827347.1"/>
        </source>
    </evidence>
    <sequence length="638" mass="71181" checksum="7FEC36BBB6F3FDCA" modified="2025-10-08" version="1">MMAKQMSDTKKEFVQKYMLDEYSRAIPTKALAGTGRGASLGEYCEPIDSKNLYKKKPGEDDINSDSDNGYADPQVFDFYLFLIDAVNVKKPLSRNPSKEEEGDVYELAQQAVSDYDVPPPVTKSQGRQRSSSPRKPSPKPRGSQVRRVSQDVTPPSLQNDHGKNGPPKNTRNSSPNVLQGPEVPVQSEFHDLEIQPERRRPGKKVVEIEYEVASAIRPGKAELSASRVAASPKTKNPLSKSNSSADSSVSVSSSLHHSASAGSRHPGHSSSPAHRKPHHPGRPDMQFSMSQPAPQPPKGAAEGVYEEPWDLKVKRLKQEQEEKMSKKLLKQAAVEQKLVNQPDTSIPVYEQAWDSAAQQRKLEERLNFARSLSTSSQTSETDIFHDALEAVPAQKGEPGTVQGLPPTTDSAGVLKPLPMDTYEDAWDLKNSVLDQQIRKMQIHASATYEEPWDRSKQQEQLQAKFQKVTPQNQKRAPQRSSSEVQEPTSEGADSKSSLVRGKFHSVDENKVKSKSKGCNIGQRINPMIPLVNQNWFHGNISRDDAEKMLCVCKEGSYIVRISSDRKSYSLSIKSSKQYIHVQIEELNMSDGTVRYILGKNSKEFPSIPEMIDHYTHHRVPLKGAEHITLLHPVECKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A700</accession>
    <name>A0ABM1A700_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC101853960</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101853960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942073.1">
        <property type="nucleotide sequence ID" value="XM_013086619.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827597.1">
        <property type="nucleotide sequence ID" value="XM_035971704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853960"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021917" evidence="1">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="2">
        <location>
            <begin position="67"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827597.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33247" checksum="D738350FBC11FF9B" modified="2025-10-08" version="1">MDRFLYLMACATFVSACLAEDGKERSRRETVVWSLDSVPDTKIADDIIQSFGPLHQWGDDSISASTKHSETRALRIYYKKGSYIKSNGPKGAGFFSTPCTIPANADVMTLKYDVYFENFGFGIGGKLPGLFGGENGEGAFKCSGGSNPPTCFSLRIVWRENGAGEIYAYIPHNQMVGFYNRSDVIGHGHYGQSLGRGRIQFKNNKWQTITQEVHLNTVGSADGWINVCVQVEGESQQCYSANNLIIRETDRDSLRGLFFSTFFGGSEPTYAAPNDSCTFFKNFQISVPDLNTTSTTSPVIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7E7</accession>
    <name>A0ABM1A7E7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012803</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942291.1">
        <property type="nucleotide sequence ID" value="XM_013086837.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012803"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012942291.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25480" checksum="8652A944C21D6019" modified="2025-10-08" version="1">MPAKLRPVYNVKGQVMDWDSIRFPVIPARPQTFTPMYLTQEFQPDPTTYNSMNDWMRMQGQVVSSRAPVMYAGAEGFKELPSVEVSEMTSDQAIDDYDQKFQRSYSDLAHQIAYRYPNPGLPRIRQGAIGGTWRHIKEVLGHHGSRVCFVDGLVSVYDSDKFSDALQPPLPYRGKLVHPPYAPTQTEYANGKKGIVFPRLEDGVDRKLRMNALPSHRGHYQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7U4</accession>
    <name>A0ABM1A7U4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oxysterol-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942512.2">
        <property type="nucleotide sequence ID" value="XM_013087058.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845419"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13284">
        <property type="entry name" value="PH_OSBP_ORP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012942512.2"/>
        </source>
    </evidence>
    <sequence length="753" mass="87103" checksum="77F1D637429197C9" modified="2025-10-08" version="1">MAEAKHHQSNFKGWLFKWTNYLKGYQKRWFVLQNGLLSYYRNQAEMAHTCRGTINLANAIIHTEDSTTIVISNGGAQTFHLKAGSEVERQKWIMALEMAKSEAKKMLRDESDEEEVQQPDRAELTMMLHTLSAKLEDLHTCNDLIARHGLALTKTLSELESAHSAAEAAANLKPVQERATLFRITSNAMINACNEFYELSQSQGRRWQRTIQHEHERRLKYEEMVEQLAKNVVSLENKARMSLSGHPVRGSDSEEDEFLDAFEHQVEERELTVALPHGNDMMHRRTDSMESYPDVSSESESENSLNEARVYTSKTSPKKGSHREHQRTASQDKIRMPKSLSTDSHGSDSSIPGRRKRRKRIPDKPNISLNLWSFMKNAIGKELSKIAMPVNFNEPLSMLQRIMEEFEYSEILDQAARCSDSCEQMAWVAAFTVSAYATTLFRASKPFNPMLGETFEFDRMDDLGWKGISEQVSHHPPMLAMHVDGREWSTWQEFTMTTKFRGRYLQIVPMGIAHLVFHKSGNHYTWRKVTTTVNNIIVGKLWVDNHGEMDITNHHNGDKCHLKYSAYSYFSRENPRKVTGVVTDVSGSAKWVLTGTWDNKMEGAQIIHVEESNKGKPVFETGPHKTMWKVRPPPPGAERVYFFSQLATEMNEPEEGVAPTDSRLRPDQRMMEDGRWDEANRMKLRLEEKQREVRKQREGEAERAKAEGRENEPYKPTWFRKERDPTTGALIHIFNKQYWECKQRQDWQRCPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A845</accession>
    <name>A0ABM1A845_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein heavy chain 6, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942648.1">
        <property type="nucleotide sequence ID" value="XM_013087194.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012901"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942648.1"/>
        </source>
    </evidence>
    <sequence length="807" mass="91514" checksum="7F49805B63B0AF7E" modified="2025-10-08" version="1">MATNQPDIMDVEAERNQQVAMDANSRAERLRARLYSYAPKMAPPPTNALQFRGVTKAQARRMLSPFGPTVEPLPSLQRYQLVNKPEYIQKKNLEALELKRRAKDATDLDDPKRLKRAGSVEPLEVIPPAPDLPQELKEKQETMVPRPVTPRDRGKSPVGKSHTSGPAVPTQAKMKFPKSYEGLRDMNQIIGVIRDQPKVGFLYMSPAVPKSSVNYHYYNLKVVSHEHLYKPDYLTISLKGVTRMRADDETEFVLLDRWEQEVFYFHRLIKIKTFALFRKWKAFSVWRKNVRTTKIKGCKKALDDNLFIVNPSLRPALLNVREMCHRISEMGLCQIDKDHTYTLTEFREAQFNQLNDVAGRLQDFRELVKEVVRSACRTALLEAGFTPDDYYYDGADSPGMYGDMGGAPGTASSYLMQSNYDMDIYGEAPEKMTYTEQANKRAHCKRLTCFIRLADYLIVNTMHVLAVNSVSTLLNYLSEQLQNTATLAEIQSYNDYKEEEEKEKKKEEEKKEEKEEEKEKEKEGKEELEVPYVTDLSYHVITTPEETRDAMMSRVDRVASLLDQLASVMDQVNTKVTVLENLEMSVITHVSTSNTHIAQLLYARLEEKLEEIKCRECRFAARKGVKDTEGSVLGLSASPGPPELGLPPAEVKAKSRWVTGSSYSHVWCLSDYGQCVGKEVEQHSDVLHLGPDRLEVMAAVSFDSHRKTRVCLYGRRCGCAVGDGSVGVLHARATVTAVRLSARGGGGGGRVWRLGCDDVIFQGESRDWQECSYIWKVLPATILCEELERQGLVSGGRVCLQFDFRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9M3</accession>
    <name>A0ABM1A9M3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mucin-5AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943463.1">
        <property type="nucleotide sequence ID" value="XM_013088009.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847993"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943463.1"/>
        </source>
    </evidence>
    <sequence length="789" mass="83840" checksum="0FFFCED6A54E2D16" modified="2025-10-08" version="1">MTSSESAVVAVVEECKDGSGANNSLALLTKDDHQDTELGAVMYIIAVLTFYSLALVVMIVKYLKTERKEMEEEIQLEKFFKGIPSKRIEHERDAVNRVAIHAFHTLTAARGHGPDSVLNSARSSYTEHLNSSRDSDDHELHGYPDDPQTRRASQHSLHPYDRVTHAHAGGHPTHFRRGSHENLGQGHMCQVTANALEGHLNGEDDYRLGTDGESYVQFRPSDLADDGCFSDEEYGRHSLYSPPYTSADGFNEREEAYNQATPFLQKDRNANAVKGYGSERVTPAVSTSERGKDRHVMWSSNDMDNDSDGCLQSPDRAAVFPSKNSEHSVKFQVVNETAGPHVNPRSTKQQKLDRTSAPPRSHTSSETADDSCASCLSTGRSSDQRDHKKKEKSGSKSRVRIPQISITRSSTSGDISVPAIDYKIGKSHHTSAESAAESGGGKNSGKGFPKPAKRTLFARSSASKDKKSGQKGAAKHAQSKNAPEKDLSKPGIPESYSSREADQAVVMSDTQSYDSSSSLLPRGDKGNTSDDSPANSPVRVLNNSAAQSKKSLSFNAALNSSKGKRESLPPVDMNPSTYASALSRQPNKSKDGANKNPAQLPPSSTAVVSNSARPDNGTSVPRYPAKQPRSTLPFVVNSSFATSAVSPSVSTTTTTTTTNATTIAAAATTTTTTATPTTTAHPAAASPTTSTTRDNSLVIANAATAMTLPASTSQVAMTSSSAAAVLPCAATEAERDGNGREDPKSPDDASVSSGQSVINVGAPQTVGTVVRFADAASTPPPGGFLVTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAD4</accession>
    <name>A0ABM1AAD4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 13">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101848919</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 13"/>
    <dbReference type="RefSeq" id="XP_012943911.1">
        <property type="nucleotide sequence ID" value="XM_013088457.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848919"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14294">
        <property type="entry name" value="UBA1_UBP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="16">
        <location>
            <begin position="168"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="319"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="14">
        <location>
            <begin position="618"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="14">
        <location>
            <begin position="684"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012943911.1"/>
        </source>
    </evidence>
    <sequence length="808" mass="89697" checksum="EBFCD3382CFE719E" modified="2025-10-08" version="1">MESGLSELAKRLPGIKAPIGGEKVYKDECAYSFDNPESPDGLYVCMNSFLGIGKRHLQQYYEKTGNGVFLHIRRLRKEVPKDETAEEEKPTKMAIGVEGGFQTDEKRFEFEEKTSITILPQWHEIAFPNPQIPDQAQLSATMIMMAEDAAKQEEAAAMAGTWEGEKLRVSKHAENLLQLPVEKKIPPSGWKCEKCDLTCNLWLNLTDGSILCGRKFFDGSGGNNHALEHYREVGYPLAVKLGTITGTTADVFSYEEDDMVEDPYLAKHLAHFGINMAALEKTDKTMTELEIDINQKIGEWDVIQEAGSVLTPVYGPGYTGMRNLGNSCYMNSVMQVLFTLPDFQKRYFSNCGQIVSNAPQNPVSDFNTQMTKLADGLLSGVYSQSVDTKEASEGDAKYIPPPSGIRPQMFKTLVGKGHPEFSTKRQQDAQEYFLHMVSVIQKNSRGGANPCESFRFEVEERVACSSSQRVRYTRREDFCLSLPVPMEAVSNKEEVRKYNESKAAGATIVDPKSIVRPVIAFSECVRAFTEAETVEDFYSSAIQGKTTALKTTRLSSFPDYLMVQLRKYTVGDDWVPRKLDVSIQAPDVLDLSSLRGRGLQAGEEELPPGDSPPEAPVEIQEGTVTQLVDMGFPREACRKAVYFTNNTGVEAAMNWVMEHMDDPDFAAPFNPAPAGGGVKGGAFEPNPEGLAILVSMGFSSEQATVALKATSNNAERAVDWIFSHPDELSQPMETEEASAPVTAANFKDGSEKYRLVAFISHMGTCTSVGHYVCHILKEGRWVIYNDEKVALSEQPPKDLAYLYLYQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABM7</accession>
    <name>A0ABM1ABM7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859895</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944611.1">
        <property type="nucleotide sequence ID" value="XM_013089157.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859895"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944611.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20572" checksum="BAC6751C7F07BDB0" modified="2025-10-08" version="1">MREAKNLCPGEDKRVLFMCRSGADMSGLACVISLLMDRLDHDHFLTIPLVVGTVKAVRPQVIATVDQYRLLYNLLKMYYDSQNVYSNFGPRSSPGPNRIVPTPTPTPTPTPTAPEEETTYANHGATQSASDRPKNLPQSSQKSKKEDTYINFTPQKIDLPDSSAADGGHEPDSNVYSNSSAIQRGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACC9</accession>
    <name>A0ABM1ACC9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101847775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012945011.1">
        <property type="nucleotide sequence ID" value="XM_013089557.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847775"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570:SF2">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="109"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012945011.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="71765" checksum="E6C9D92C625A2A49" modified="2025-10-08" version="1">MAKEVLQLPTMAEQSNVIVKRRKRNRCCCYLFMVSSMLVLVLLLIILPPALNSQNFEDFEWFSSSSKNNDVKSGNSGTSNDTKNTDGNNAEATFDPSVVVTPKGSYRAQMLQHVRVFRGIPFAKPPLGDLRWRPPEPVEPRPPSDVYNATYSRSGCPQFCNLHPFCPEKTAEDCLFLEIYTPTPTQAVKGPSSLRPVMVYIHGGSFLTISITAKEFNASIMVHRSDVIVVMLEYRLGVLGFLYTGGGEEDSPGNLGILDQRRAIEWIKENIAYFGGDPNRITLSGQSAGAQSVLIHLLTAETKGYYKHAIIESPPAFLTYKTTKEARDVMAVGLAKELNCLTKFKDVDMACLRRTKVEKIVKAQEKFKEIGETIYDRAEPWAPVIDGIVVHYQPFEALERYSKEDRSIPTIYGVTSEEGMLFVRLYIKSRVLPIVYPIELSVIFKQKDDIKNLAKFYPNKDKTDARESYADILSDFIFRCPRRLVMNQIFDGGWNDQWAYMWEKPADFNLLGSLAACSHRACHGVEIMFVFQTFAYFNMNITAEKIRLSNYIIDYYANFIKYGNPNGLSSGKGAVEEKGENASSLLFWPRLKDSGGTFRQLHFRSHGGINLSDTAQDKRCDMWDKRGYSLISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACE9</accession>
    <name>A0ABM1ACE9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101860858</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101860858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945041.1">
        <property type="nucleotide sequence ID" value="XM_013089587.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860858"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012945041.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11621" checksum="573DA41296AEBAB6" modified="2025-10-08" version="1">MVWVASGIIVGTPKVMSQFVKDFRAARSELLAQNMMSTAQQILAALYSKKMKAQPSIGYSLYSCKEGQFGMYRSDRVYFCFGFKCKEAAEIRSVGNNGTVTKIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD84</accession>
    <name>A0ABM1AD84_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101847162</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945472.1">
        <property type="nucleotide sequence ID" value="XM_013090018.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847162"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046097380" evidence="3">
        <location>
            <begin position="30"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945472.1"/>
        </source>
    </evidence>
    <sequence length="612" mass="65302" checksum="BE23B04C5BE3B610" modified="2025-10-08" version="1">MVLTQRCVSAPQLLCLAVLSSFLLGQAASYNCSAGSACGWLAVCSDHQCVCQDPFTLHANGRDCQNDSCSSDSCLQCDTPDVCLKCVSFISQSAGVCLSRCEGTAEERDGNLVCTGRDSEGVDVVVAVAVGVGAGAVVCLLVVIGVCVYVRRTIRNVDLQSKHYSSRQMETGHVKQFPTYQNDGFETESQADYSPHRIDPLEYANELDRLRPQADTLMALLSQTRSKTRAMAASDPRLPTYKGVIHQLCRVLVLLHKKDPVVSIPSDAPGLLHWAQQMLDDHREQQSSSGGTIELPVAQISTVDLGLEAPTSPVYATPDSSQGHSSPIPPAVASPYSSVPVPVNHGTFGRSKRPGFATISRTPSVPNGALIRSLEADDNIQNIFAGKAESNPGAESRTSTFLRREDFQSFLIDGGEKSEAHNSSLERSSNKENLASESVQTISKVDGFDGEAVVEMRKRTLKPNQPAADRPVPAQKPARAKYPGAAPPGGGIESAKSVKKNIITNPNAIKKSSSLTAKHGKASTSAPTMGYFANGHYYDPNPMPVQDGELYAPGSSYSDRSNVMSTFLGDLPNSRSPSASSCEDDGEDSENSGGDLDVFPFDPNDATDPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADE0</accession>
    <name>A0ABM1ADE0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein starmaker</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945542.1">
        <property type="nucleotide sequence ID" value="XM_013090088.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859372"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945542.1"/>
        </source>
    </evidence>
    <sequence length="741" mass="82048" checksum="EC223B7DF9F6F412" modified="2025-10-08" version="1">MTSLYPGLLFYSSGLNKKSTPTKPEATPSEIDRRLGRAPFNGRPWPKSSPVSTVYDVRNSSTRMIILNNKLSKRPKGSRLRGQSDHQGEIMQPEPNRHISEEPKTNCHHHKNCTLSVSEKFVPIFPPSVSPSPAWVNNNQRPPMRFDNGSLVNPNHHIQCQGHMDYDIMRWYNANRRPRSRVSTAKEDRSMSPILNGPGLSRGEKRYLTSIAKIYSVSDMRAQKQEQYTQLMWKEVNKGTYKYRDWEKYNRYLATPRKTQFGPCDPNRQSRSLSAPGGRKPSQSRDPDDESRPNTTQTTTKPNRSARDAQSTSSSRGQRPRERPNERRAVGRQNSQDTGAKKSGKARGSGDLTGKSARVESPMPLKSRDALAPSPSLSSLSDAGDNQEDSKRSEQKAKTSPVVDLKHSKETKDTKAEPQQKTQPEDETPRATDVTITVEEVHDRSLGDEDERSKISARDTHEQRGNAVEYHPTYGDIGGQDERSREKDGSEQEPRTSTKETYQPAKSPSKLEESKKEEKKGTEQPKQQATSGEKGEGTGKKGVVATATSSVEAKQSVEEKKEKGSDGAQDTSGEQDGGDSFAEDGPELKQHVHREGKDRPLSRLGGREQLMVVKKENENSDDDYSDDDEESHRSRSKVEESTDQARGGHTEPNQTTHDQKTDGRDNGALADNSGGVRGGQDASQPHTDDHYSEGSSRPTEESNTGGAGGSGKLGETVQPATPTEASSVSQEKPSDISTIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADF1</accession>
    <name>A0ABM1ADF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rap guanine nucleotide exchange factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945561.1">
        <property type="nucleotide sequence ID" value="XM_013090107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848483"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF224">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="797"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="960"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012945561.1"/>
        </source>
    </evidence>
    <sequence length="1196" mass="130313" checksum="0F94859BDEA1A79E" modified="2025-10-08" version="1">MEESEGAALISEGSPEKTSGSKMLKKAQSFREDIKNKIRRRPSTGVQQMIPDGKGNRKSKGDVTPGEGRSGDDDLDQLKAAMSEVNKTLIFIKAVVSKGKTEVLPGSASVILETVMHIFTLLRYPLLAQESNSLSSSQSKVCQNLAKFIQWTDDSLVGESKDGCDKERAQDIIDTLLEGIKELTQLGMEKMSQRKSSSMLQTPITSQPLPSPPASADGSSDIPLSSREQEILAQTGGCAYDNLSAASGQRGSNASSVFSFDSSSSTADSADMPPPKPPLPQGSNPVLNRLTSSDQDSVDGGQDLVPPPLPEKKRSPSTSLDILDSVSGRASTCSTPSGATPSTSTHPSSLVSSASLDHQLGIAGRGSLASLPGNTLVSGGIVPGAATNGGSPVNHLSLGDVSISQSSSSSSSSSLQATQSWQQQKDSEGGPSTTTTTHTFSRTVSDSKLVSSTVVSRKATTGGKACDEINQLTSQIKKLTHCIEDTPPPLPAKKGSGLHRLNSQYDNVPDGLEDRVAALTSVGSSVTMSQQRTVVMRKMESRISSSSTSSSQSNHSNQSQSITSVNSHKSMQSYLTEQSAGSHETFSSSETFSSASHSSTESLPKPPPLPPKKKHVQAYMRTFGALTQPGLLEEAISRHSITFYEAQWHQHQRELFYPRSNTISVFSDISSGSSVSGGGSSERINSMPPLPIKINRLSDISHGSQLSTGSSQSSSSAGDLLSLDKSTAADSVSVASQPQRLSLPQPVAARPPPEVKEVAPLAQPEIQKDSDSDFCELNLLDDLDISDQLILKQEGEEGPEVRGGAVDALIVHATQAGKIGSEGDVTEQEEFMFQEAFLTTYRMFISPKALMEKLLYRFHKFQHAVDHKKKLAHNAFSLLIRVVDELGCNELDSTIVDRLMTLVYDLICEGALNLARLLRRKLLEKCEQKQTEIAEVQAALAAPVQSIELGSSTGDLLSFKAHDIAEQMTLLDAQLFQKIEIPEVLMWAREQSEELSPHLTTFTEHFNKMSYWCCTRILTQDDPRERERYLMKFIKIMRHLRKLHNFNSYLAILSALNSAPVHRLEWQKQNVEVLQELCQLIDSSSSFRVYRQTLSETPPPCIPYLGLILQDLTFINIGNQDKLPEGSINFAKHWQQFNILDSMRRFRTSCYQFKRSEKIMGVLNNFKDHLSEEVLWQISQKIKPSQTGHKKQNSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEH3</accession>
    <name>A0ABM1AEH3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Receptor-type guanylate cyclase gcy-28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC106013880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946142.1">
        <property type="nucleotide sequence ID" value="XM_013090688.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013880"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06373">
        <property type="entry name" value="PBP1_NPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046296418" evidence="10">
        <location>
            <begin position="31"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="11">
        <location>
            <begin position="186"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="88"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012946142.1"/>
        </source>
    </evidence>
    <sequence length="743" mass="83123" checksum="15BC62FAB44B97D7" modified="2025-10-08" version="1">MYPACGVPRWSNAAHFWMFISATLIIRTCAQTTHFEKATISDSGGGGSGGGGGGGGGDDEVTFDPEARTTDSSPSASYLYSGLTSGSNNKNNIDNNNENRNNNNNNNNNNNNRRYKINRSTSNNPNTTTTTTTNNKSNNNNSNNSNRKISSNNNNNNSSSNTTTTAEVAVILPFDDRFIFGKKRLLPSIQHALDFLSDRDVTAGFGLNFRFSDSRCSDKDAPLKAFEFYRKNQVHVYLGPICDFALSPVARYAPAWNISVISPGGLSHTFYEQRRQDYQTLTTVGASFKSLGDYILTALRFYRWKRVKLVYDAKIALYSLRRYCYLLASAVISSVSQSKDINGTFFMYVPEKNRAEEILKEEVGTQDGVIVLCASTEAVREIMIKAHELNFDNGEYVFFNIDLFSSDNATSMPWYNASDTPERNEKAKKAYEALMTVTLRKPTSPEYRKFSREVKARASTMYKNFTYGEQEVNSFVGAFHDAVILYALALNETIEAGGSVTDGHEITKRMWNRTFQGITGTVSIDENGDRNADYSLLDMNPETHKFEVVADYFGNKREYTPVPGKSIHWAGGRLTAPPDTPTCGFDGSKCPPDKPFPEYGIVIIVLGSILLVVLVIALIAYRHFKLEAELADMNWRVRWDDIMFSGPTRGKKPSERQNGHRNSYHSDCSADTIAVHLSDVNNRQLFTKTGYYKGAILAIKPIPRTHISIQKPLLLEIKKMKDLQNDHLVRFHGVCIDIPNQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFY2</accession>
    <name>A0ABM1AFY2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106014210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106014210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946883.1">
        <property type="nucleotide sequence ID" value="XM_013091429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014210"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF26">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012946883.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16409" checksum="706E6B7DB743F9B3" modified="2025-10-08" version="1">MYQSAPGQPCTVPQIMVKGQKPQAADHFTCLGSRLSRAVHIDAEINTRVAKASASFGRLRKNVWERRGLSLSTKLKVYRAVVLSILFYTSETWTVYNRHAKQLNRFHLSCLRKILRIQWQDKAPDTAVLERAGTPSIYTILHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPG0</accession>
    <name>A0ABM1VPG0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-splicing factor CWC22 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824302.1">
        <property type="nucleotide sequence ID" value="XM_035968409.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857469"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="243"/>
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            <begin position="257"/>
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    </feature>
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        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
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        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
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        <location>
            <begin position="446"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824302.1"/>
        </source>
    </evidence>
    <sequence length="696" mass="78159" checksum="147DBDE9E01E7EE2" modified="2025-10-08" version="1">MDTAASQNRAEDYRKEFVDKGTTPTSSETDNCSVHTEIERVAEPGSSGKRRWRSNENRRQNKEKSRSQAGSKRRVELRDYRFKQKSLTNRESSLDSGEGGGDEEEDDGDYAVKQENSGDKELSSNSGNSERQMDVSGYDPNVRNTGVISDSTGILKRSPNPYLVKFPQPCQFSADSRLLSEVVVSPFGESATLTEQQQHKLSVATYDSAVSTMSTPSAVSVSMESRVFSSPSNSERSKSSISPKRPRSPELTKALRLRQEKLKRNRDIDETRIRLKCQHVGEKRDRGSSRGQSGERAGSAAQARRPVLERARSEDSSKSFLRHLAGKDSSCSLGSMKEVEERYSRRKTRSKSDSISKSPLSYENKGTSPDDSPMQNTMTPPAIIETSATSEVFERAPSSLHDKNYPSTHTAERPVTLTPLERRDSSKSSRSRDRKDKEAKKTSQYSSDNPRSSKSKRSSQISKSESVKNALPADDSNPQPALPESSNTDHPTNPARLPNEDTSHGRIPPPETALDSLASAQEVEKTTAVTMDAILRDGLPDIPALENTTESVVIDWRGVFRVEMMRLRREVNEFRKFCQDQIKLHALALENSWSGKSRPDGLQSKNGLRPSEPPRISEQLKDLEVNMELFQKKQRLLDLETEILAKEERLSGKQKDLEEYEKEIIDVEAMLNHRQAICDRRQRALVSLDEVYNSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQY2</accession>
    <name>A0ABM1VQY2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein EFR3 homolog B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824824.1">
        <property type="nucleotide sequence ID" value="XM_035968931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859921"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824824.1"/>
        </source>
    </evidence>
    <sequence length="800" mass="91617" checksum="1EA121DCAE51ECC1" modified="2025-10-08" version="1">MEPSFERICGCCTALKPRYKRLVDNIYPANPQDGLVKSEMEKFTFYALSSRPEKLDRIGQYLERKLSADISRHRVEYVFISMDILDQLLVSCHAHSLNLFVESFLKMVQKLLECGDPNMQIKATQSFMKFANVEEDAPSYHRRYDFFVSKFSSLCHNNQQEVEVRRKLRQAGLKGLQGVVRKTISDDLQVNIWEAVHMDKIVPSLLYNMQDQGYSPSSDADDSPREEEEPSHMAEVVFRDLICRASYGNIKSVLSPVLIHLDNHNLWVPNDFAIRVFKIIMFSVQSQHGYLVVQQLLAHVDKHARSDPRIKTCIVTVLYEAVLIAAGNSTGPSVLEVFNNLLRHLRISIDRKSSDEEQRNEEVKFEEVVVNTIGEFANNLPDYQKIEIMMFIMGKFPQFTNEEEIGKLDKQLSVNLLRTLLKVATKYKTVHLSQAFPPEFLHPLLRISLVDDPGMRLIVQEILHTLLDRHGNSQKLRQILIPKDIGSLHLSIKMDSRLDLLFMKKSGMQLYWHILENLQLESNRVDNFEAIYCTMCLLCLEVGQDEVIIELLRLALDIQQMALNNSGLPRTHLCAIHSLVAAFLNLLAQVTNVGSLSHYVLRVLENRELEGKHLLPDFAFNRSNRPHSWSEEETEESYPKNFEVKEAWLFHQERMADCVRSAGLDVTRLSTPFSARPNLGVGSGEGSMTVSDVASINIDFETAVDGSPRILKRGEDITVESLKKMLAEDGSAYKAEEERHRREVVNMFRSAPFEEIVARSEAKSNQFHSKLSEILEMVSVEKLPSEPQSQDMVFPKLFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRN3</accession>
    <name>A0ABM1VRN3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DmX-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825075.1">
        <property type="nucleotide sequence ID" value="XM_035969182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847815"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="3">
        <location>
            <begin position="1699"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="3325"/>
            <end position="3366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1682"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2175"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2259"/>
            <end position="2297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2388"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2723"/>
            <end position="2743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2783"/>
            <end position="2820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3072"/>
            <end position="3091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1682"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2182"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2207"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2259"/>
            <end position="2276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2783"/>
            <end position="2798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3072"/>
            <end position="3086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035825075.1"/>
        </source>
    </evidence>
    <sequence length="3422" mass="379872" checksum="40218A60AB821430" modified="2025-10-08" version="1">MNRHQILTGACNGGDCYALGSVEGVNFVAYASGCDIVILASNFQRVVTIPGVLRGSIKVSCVDCSTDTGKIAASFGKKIHIFEPTPSNTDSSHPSPSGSKTNVGKKLDYRWFPTAELDADCYVRCLSWNVEGSRLLTGGEVIQIWEFVNSSPVPVASAKVQFHLGSVMGEEDDPVTQRLVQAIADPDYLTDHQGEPEPGAWECVWKTKPASPVTHLKYSPDSFVFASLGKNERLVKIWYEDQKVSQGLMRHDSVMSPKKNSIHYTFIYICHPRAVTGFEWRQTSKYMPRGSVANMLVTSCDDNVCRIFVETILPDAGLLDLEHFDPAMNADPKYHTQRHKKRFVQRLKNIRQAIHKRRKHPKSGADQPMNGQNLQNSTSVHDFHKFAIHHNGVSPVLHFHLACSINPDTDIPLLPIVGSKDDVDSNFRLHWLNNKDLEFTMEAEKLLQELHQRLVADEGGSLHQSSTPNQTLSDDDQSLREEDEDFEDGGNEEDSQQKRRSKTGKNDMRSGQGSRSSLSSNEDQHKDDQPPEFPLHLLQSGVIDRLDRKIDALLLDWHSSPDYVFSIHPVDGSFLVWLIDHLDESTPFTFHQAQASFSSRLPRAFPIPDARSMASNLLMYCNYSRVDVKTMMKMNEGITDVGDVHSGGGAHNKSATHSSFFGDGDNNSLIPSIHMVTKHSNGTLNQWQVSFTEKTKFQNIVSVSHVARACGHRFRTNSAACHPVLPLMLTTSHHNLPSTDGTDARTPGGSEEGPSLPETPDVEQVGPTFCSELILWQVVPVGPLSRSGGITELCRINNSCQSAFTCVAWVPTLLPSTCLGSYSNSPSALFVASDGQCLRLFQAVIDARSLLMDRTTGMETKPSSSNMSSSTCSSYPETPTPSQHLPTWTQQLFNIASLQSSTRPGCVLELDAISDALQDWQNIQLLHVYQEQLITGEEGDNVTEAVVDLSGQQTFDENFFLVVLEKPPGAGTVLHMWKLTIDSKPSAEGNVNGGYDWNQYENLVDSYNDELSPDGLNYKQAYHNNSGSHQVMTMSVRTTKVCTQLLPLPDEVEVISCSVAGGHLSSASIYPACYAPYQFVTACSDGEVRFWRCSLSAVSENSMETSVHNVTSYEFSLEDGDVKGQPQVESRREEQRLDFEYTWSEWERPCSAADRSSSVSVSGRPIAVSCAYSGRIAVAYRSGPVRAQSEHPEDKYVNLRVVILECESTGGSEWVQEDVIELNNIKIPDPKNEIDMYMLQSVENPQIPDPTEAMQLPAAQTAAAFMTRTKSVPSLSTIQSVRKSISEKGNKKGLLRQKCLVQLDWASTEDGSHLLTVGVGSKVLIYGQVSNEIARSLKNLNSQEEKKTQEDKRSAFASSKKLTMNKSMVAEEFQEEIQWMRLKGIELTTADGLPPLPMHISWVRAGILVVGMDNEMQVFTQWRTDGADVEVIEDESTMDKRTLTEANLVTAASSLNLCHNFKSKSNFKTSLSMSNFKHLTVNSGQLPSSKKDAWKRSNQTSATSKGSISLARSDSISSLPMLYDSGLFEAAKFANPVLPQYHPKLLMELLNFGKTKRVKAVLAHLVRCISGSDGVQTIFSEDHLDNGHLSVKLSRQRSVSVRSENDMDAEAAPINYVEIKSIPPLPLYALIAADRDATPFNSEIASKTATGQQNRETDYNDLLNPNILRNDDDELDDQLLLSTSADSSSSNPRRPRLPSGSAKTPSDPYCFTSAQANILREYLFKLNLPGLSGNDQFYLAALAEVVGSTALEFNDDYDESQKKEQGSTDDCGLRFLLAMRQYQCLVMTLPPLLRKPLLSEGIRTFHLVWAFHSESTQELLSAIPCVKADEPTWSELKLYGVGWWLNNMTQLKTLMLKVANTVFKTTKSPIDAALYYLAMKKKNIMKGLFKTVRDSKMEAFFALDFSVEKNQRIAKKNAYYLLGKGEFTHAAALFFLGGQVENAVSVILDKLNDLQLALVLCRLYDGESIMPESVKKLFYENVLGLDKNGENYDARNASPDPFLRSMALWQMKDYESSLRTLLEKNIGRAMKGETDKLLQIPRVFNFYNFLRTHPLITRLRLASSSLQQRAQLVSGFTHTDNVVSEGITTLDQVTPAERQLFFAAAHAHFQNGCPLVAIEVMRKLPKRPLLVEEDLQKMAYFAKRRRKSMSDINCSTGTLRDVNLMTVNGGWNSNGDMSSSPLSQNSASGLSNSSSSSHRAADLFSSPQPASNASQNKADNFNWGQSLASSNNNKDTASSIDWGAPVSRVTFKDELDELDLGLGDSDDEEEDEDGEGVNDGKRKGESNENSSPSKLDDVFGTEAEEVAEQEPNHIDIMAQQYKFIACLKVLMEELGNLATGFEVDGGQLRHQLYIWLEKETEVLKVICNYGISQESVAQQAQEIHNSSLDDQDLLDVESPRGRTSSVMSDTSAGKASLHEVFKAEKQDLQSKVARMARRKAWLKANQHLLRTLASYCIQQGSAGGGLASVRMELLLLLQELQQERPQQQLLSPLPFPTTLPLLSASITNCRSVIADPIQYLQGSIQDLLHAVVEMNSPPNAHTDIGVVSTIRDLAVALSSCIYQSLCDSDTFSVADSDSTDVGIDGFINPEFSYPSSHLMAGVKKSRHRGTGGGDEVVNTPPAKWPGVTSLKVLLAREKDEDAPKINVLLTESLISVYMSLLISAFSMYDPQMLYRLVANKLDAQTWAALFGGGNKTVVRLEKASVPRSQDDVSKHRMMFNMRVMSNSGGGPGATKPSTETKETYQEKFVPPELSMVNYFMTKPFVASSETIIDYDSDDSFVSEDLSDEDLSDEDDDDDPTFRTRPKSLARQPPNTEHTDSNSYSWSIIRFAVIKSVRENINTFLPQIGIELTELPNVSPLLHSVMRVLEQWEELLQIRLDMFSGAPDNYIPGLGLSLTAGQPRSKLQALLVPENSPFLSAQATLPIRRLWFQLLRQDSLKDLFLRYIYRKKKEPEENEAASMKTSSSDNEQQVRDPMKIIHKEQDIITSFTLNQANSNLLALSTQKEIVELDIGYLLRPPLWLEDDNEYDIELLKNYADNDKDWSFKWSGEEWRLIPNPGPELPEFLVVQTPQDTPQPMSGSQTPGSPYVPSPNASQIGLQTGRGTSVPRSHAKTVKSLSSLGVNNPIYSHFILDRSRRLIRPILRRPVLGVRRIGSHPILPHYLTGGADGAVRLWEWGHGPPITTLRQPGSFPKVTKVLFNAQGNKCCVSDTEGSICLWQVGLGSSFNKPIMSLQCHNRTTSDFQFVGSSSLIATAGQSSELKNVCLWDTLLPTRSSLVHAFQCHEQGSPAVVYASRQHLLISGGRKGEICIFDLRQRVLKHTFQAHDAPIKCLSLDPDEDYFVTGSAEGDIKVWGLKIHQLIFSFPGEHSKTTFFKNVGSTSGVAQVTMGPLNHLFSCGVDGSMKFRQLPERELVVHHWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRS2</accession>
    <name>A0ABM1VRS2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melanoma inhibitory activity protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101849366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825114.1">
        <property type="nucleotide sequence ID" value="XM_035969221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849366"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051500">
        <property type="entry name" value="cTAGE_MIA/OTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23158">
        <property type="entry name" value="MELANOMA INHIBITORY ACTIVITY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23158:SF33">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046766215" evidence="9">
        <location>
            <begin position="31"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="886"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="976"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1093"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1395"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1585"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1717"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="592"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="812"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1098"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1399"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1414"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1717"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1742"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1775"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1807"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1835"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1854"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1871"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1906"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1941"/>
            <end position="1952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035825114.1"/>
        </source>
    </evidence>
    <sequence length="1952" mass="213502" checksum="6FD26CD237FF3124" modified="2025-10-08" version="1">MAAHSRSRATWTQWGSVFTVVFVLATTVLSQQPIIPKKKLCGDNECKETISLARALNRFSGGDHPLQLSFKAGQLIYVKSKSVEENLWEGEADGQTGYFPRSFVKEFKVYVEKPRFEIETEGNPFDKIGRQAPPPRDRRPRDPAEGSPPPPEQVEPSGKEPEKRDDAPETHDDTPENGDNTPDSQRDGASDSQTVPVVDTAPTDDGSEKESGKNSGIPSPETHDGADKPEEKLVGKEEEAEEKTAEAGDRSADSSVDRDETELEEDEEDEDGDEEQPEELNPEIDASQWEELEDTEFEEERDRGDTAGFFSGFVDSVKDLNRFLKDKLSSGDSAKDSVGDSQVKDSEQGSDKADESGAASTEAGQEAGQGVGQGAGPQQPEVVREPVVEEEKVKEEKTKENVKEDTTDETEVEDSEEDEFDETDMEDDEEGDETEADEEDDEKDEKAEIEEGKYEENNEKDKRTEPEDTEDREKEEKSAPEHRDIPGQQEGDTAPKDKEDETDQGDDDDTLPSADVTDDHSGTGKKQEEDKVKDIKQEGEEPEDKGGSSEHSDSHLGDSQKEGEMDQARSGADKMAMGDSPSGGESTEDEAAEPKENEESKEIVGDDKSAAAGEKTEGDKGEGDGQKSSHQPADTLQFKSEKTMEEADKEERSEGRDGEVKEEEGVPDSGSEPADAGNVDSRDLPGSRSVGSQTDSTNVQQEDVAEDGENVAEVEKKKEEEEKKEEVEEKKKEEVEEKKKEEVEEKKEEMEKKEKVEAPADVKEQGRESDSTEGQHVGREISEHEGEKSDNSTPEKAQDEGDGKPDGAAAGGERDSPVDSKSGEGKVVTEGEDAEGGLKADLFGEVDPMQDSIADLDNWQRDETQPILDGFSNFLHGSRTPPKANVAEAAADGAAETPQLEVPPSTVSPADLASEVISPASEIAFSKTELPEADNTGEGEKSGGEVGEGDGFETIVEGGTSLVLDSAGNMISVVLPTEDASSETETVGSNTAAGEKIPQSPVVVESLSGPPSSTAAPVEPTQVETSLPSAAVHGDLETEKINTPEVGGSVDGSQHERNATDGGDVLPDDGSPSLDGNLARDAYGNVEFSSRKVLSLNQPGSASAQQQQQQQQQQQQPQQGQVSVEATPSVPVASATERVDDLMSDNAATSDPQPGEGTGVEQPAGTDEQFTGSPQGLNENAETSTQPSTGDFGEIPTPPLPTESRQPPDGAEGQGQEDYDTEVVYSRRINDEDLYAREEEELAKNAPGFASSVMKSLDSFTKQIIEKLPPSVQSLLEQEPLGLSPNMAVLVTMATLVIFVTVSLTSCCSSGGKKKKLRDSLEVIQELEAKLQLAIKEKENIEDKIQGNDDENVKMKEDLAKNKRDSSKFQSELQTVQLHNETLKKQISSLEEEVKELKQNANSKQGEAKQQNKKTKDMEKQIQKLQEREQKLEQETQRLTLDLRHKEESVTSLTSQLTGLEEQIGHLETSKTQLLSEAEDWKEKVSDLKEQVEQRDEEFKQMQENVAFKEKEVEILNDCFLQLKSFEGEDADQEDESPERMQEKLKAMTDVSKVNASLKAVEEEKDVLSNKLTIELEARRELEEQLEGSRRSVESSMADKMKAERQCQEAQTKLNVLSSYFKEKEMQLQRELGEQEALKKQNLNKLVSADETTRSIQQEVEVLRTQTESLKRELSSSERDFRGQIAANEKKAHENWLAARAAERELKEARHEAGMLRQKLTDLERRQVMGPGGLIRPLPTRGMPPPGMLNGPPMPPPGGPGPGPNGVLPPLPPLHLRDRDRDDDFLASPRSDRGPLPPPPMDRRGPPMLPPGMRPPPPDARSPPPRMPPYGDARSPPPRMPPPGMLDGRSPPPYDRRPPPPHMMDRRSPPFRLPPPDMLPPPMRGGPPPPPHMARGGSGSPSMGRDSPRGMEPRPDGRYPLPPYARNLPGGSDKPSPRQGGPTSPRQQQSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VST8</accession>
    <name>A0ABM1VST8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat extensin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825480.1">
        <property type="nucleotide sequence ID" value="XM_035969587.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477633"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825480.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11170" checksum="434D4C722D5FEF36" modified="2025-10-08" version="1">MSRSCFNLVIYLWSPSLTHLPILHLRLPVGPADPPQCQVRRLPVGPADPPQCQVRRLPVGPADPPQCQVRRLPVGPADPPQCQVRRLPVGPALPPQCQVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSZ6</accession>
    <name>A0ABM1VSZ6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17" type="primary">LOC101849615</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="8"/>
    <dbReference type="RefSeq" id="XP_035825538.1">
        <property type="nucleotide sequence ID" value="XM_035969645.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825539.1">
        <property type="nucleotide sequence ID" value="XM_035969646.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825540.1">
        <property type="nucleotide sequence ID" value="XM_035969647.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825541.1">
        <property type="nucleotide sequence ID" value="XM_035969648.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825542.1">
        <property type="nucleotide sequence ID" value="XM_035969649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849615"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="10">
        <location>
            <begin position="77"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="251"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035825538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035825539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035825540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035825541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035825542.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="63217" checksum="1423CE78E24E650E" modified="2025-10-08" version="1">MYKKFKQLVRADKSSGHVSEQAFSAKSQLSPEVPLPGRSGPTSTNKMASIVSADEVLSKIRDEVVHEGHGASHVFLIMGASGDLAKKKIYPTLWWLFRDGLLPPKTYFIGYARSKLSMPALQKNCLPYMKVKEGEEDKVKAFFKLNDYVAGSYDKTEDFMRLNKAIEEKGSCNRLFYLALPPSVFETVTLNLKAVCMSKGDKWTRIVVEKPFGRDLASSNRLSNHLAALFKEEELYRIDHYLGKEMVQNLMVLRFGNRIFSPIWNRDNIASVVISFKEPFGTQGRGGYFDEFGILRDVMQNHLLQILTLVAMEKPPSTHAEDIRNEKVKVLKSIHSPNMEDVVLGQYVGDPNGSGDAKDGYLDDPTVPKGSVTPTFATVALHVQNERWDGVPFILRCGKALNERKAEVRVQFRDVAGDIFPGGEVKRNELVIRVQPSEAIYMKMMAKTPGMSINAEESELDLTYGSRYKDVKMPDAYERLILDVFMGSQIHFVRSDELYEAWRIFTPLLHHIEKEKPKPIPYVYGSRGPPESDEFFKKFNFTYSGTYKWPHSNSSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTK9</accession>
    <name>A0ABM1VTK9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Apolipophorins-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106011801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825751.1">
        <property type="nucleotide sequence ID" value="XM_035969858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011801"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047317010" evidence="4">
        <location>
            <begin position="18"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035825751.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="57075" checksum="FB2FD1286AE01B4E" modified="2025-10-08" version="1">MEAKLLVLLALVAVTIAATIRNKDSLAFDHSVGRPDATTARAEVEERLRVICDTSRNDVRPESPRQFSELVAAMRSLSQGDLEDLYKMLKTKTLCPDNDRTNKFFLDALPLSSTDASVKLMTSLIASKDVKGVLAQAWITSFGFVQTPTSEMLLSAKTLVDNEDTRDDALLPVSSMVNNYCRKMTSCDQDYAVLSIMASLERNIGYRCDVSGKNFEKVLLSLRAIGNAGHASRAVGPINKCLSSPTNPLEIRVAAAEAFRRMPCEAKENELWNTFENGDLDSELRVAAYLALMRCPSDATLGKMAASLLSEEDDHVGAFVYSHLTNLRETSDPHRQDIARAVQNLALEKEFELSTLKYSRNFEVSALINKLNMGFAAESNLVWSSVSQMPRSISGNLTVDLFGQAINLMDFGARLEGLEYLVKNLFGPYMPEEDRSDQKFKSRAKAEDVEGSIYGRIFGNEMLFMHSKTMKSPFKKMPSSWLDLLIQLSKKQDFALTQSAQFIDTCLLSPDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUL7</accession>
    <name>A0ABM1VUL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Zinc finger protein on ecdysone puffs isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101859789</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005100196.1">
        <property type="nucleotide sequence ID" value="XM_005100139.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826109.1">
        <property type="nucleotide sequence ID" value="XM_035970216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859789"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026811">
        <property type="entry name" value="CIZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491:SF9">
        <property type="entry name" value="CIP1-INTERACTING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="699"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="604"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005100196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035826109.1"/>
        </source>
    </evidence>
    <sequence length="735" mass="80510" checksum="9E4BF72123A0097B" modified="2025-10-08" version="1">MHRNRQGGRDRSGGRNFRGAMGPVGFGDGLLGEGPPVGGGSLYNEQLANQNQMNQLMLAQTLLQQQALAAGAGFGGGANSADLSAMSDLGGMGGFGGGLGKMQFLQSQGGYGGGGGGGGGGGGLISDRKRMASRGRDRGYDVKRRRHDSYGRSGDRERSGNRDGGRGGEGRDRNRSSRWDTGRDASGGNDYDPAEPTEDDDGHRDKDSNLYCHVCNVSVYDDESFRRHLNGTKHQQRMNNVLTVHQMKSNQLKSRLKAEEHLRKIEGREGRDAEFFCKICNNDLTVPWKYHSVSHIHRQRLLQVRRGCGWCNVHDFNNFTEVLEHRETDQHKKNAELYGKKDDKKGSRPRNDDRNAEWHRSSKTSSQYEKKGNGKMQKKTKPEEEVVVIPEYDPQTPIGQNYVVPVTGFFCKLCHKFYCNEKSAKVTHCQSEAHYEKVKAALEAKNAAIEKRKAETEAKKAAEKAEKKGSKGDKSEKTDTSDAPEDGVEVEEEEEGGEEEEEEEGGEEEEEEEEDYDSALAPGDAKGEEEGDEFDDKELSDDEAMDDGDQEGGSFLDETGANSSFDFLSGDMAQAHLELQRQEELLQQPQQGQEEEEEVEQGEENGSISASEEAEAPSGVDGAEAEAHLEGEVEATVEEGEPETTEPATTEPVEPAEPAKPEKVEVVKEEVVKEKVVNAESAEVEPVVAEPVEAEPIEAEPVEAEPVEPPVVVKATPAKARGTARRGRGRGKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUQ8</accession>
    <name>A0ABM1VUQ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NF-kappa-B-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101859574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826150.1">
        <property type="nucleotide sequence ID" value="XM_035970257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859574"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="569"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826150.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="76902" checksum="8EB6B625FCB20703" modified="2025-10-08" version="1">MPRRRSSSSRSRSPVRNGHRGGSVSDSSDRKPTASRSKRRSRSSEEEHRSLHNGRAKRNTTVRDKKHRQSPSSSASSSRSRSADSASSRSSVSSERDRKKNGGVKSHRRSNRSPSPDLRKRDSSNNHRRERPRSPVQRKYRRSRSRSPSPYKKRRIGRSRSDSREDDRSTFRRQSPDRSKGKRRSRSPKLPSLLDPGRFQGPTAGFVDERQKSKSRSPSVGKNHRQMSPTSRERNFAEKYESWDRDNNRPIRKGKRQHEDSSGISEWRRQERERIGTFGVLELWSRSPAHEEESDVEDEGKKKKDKEGKGKKKKKKKEKDDSDEDEGDSDDDDDGSGKKRKKSSKKKKHKKDKRKKYVYLFRSVQLCDVCLCVQNVLASWQKCRERLRSWSEFLQVTTSSDGCGEGNDDCNVKVCNCGEEYDSCNVKVCNCGEEYDGCNVKVCNCGEEYDGCNVKVCNCGEEYDGCNVKVCNCGEEYDGCNVKVCNCGEEYDGCNVKVCFRKSKKSKKASKKKKKAKVSETESDSDSDSESGSDDEPVWLEKTKKPKNPDDEEEIGPSPYVEINALTERDFGRALLPGEGAAMAAYIAEGKRIPRRGEIGLTSDEIEGFETVGYVMSGSRHRRMEAVRLRKENQIYSADEKRALATFNHEERSKREAKILSQFRSMVHERLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVM6</accession>
    <name>A0ABM1VVM6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-5AC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826468.1">
        <property type="nucleotide sequence ID" value="XM_035970575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477910"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826468.1"/>
        </source>
    </evidence>
    <sequence length="905" mass="91167" checksum="34A275E842A4F172" modified="2025-10-08" version="1">TSSPSSPTSTLSSHTSTPSSSTFTSSSSTSTLSSPTFASPPTSPPSSPTSTPSSPTSTPPSPTTASSSPTSKPSSPTSPSPPSTPSSSSTSLLSTSLSSTLPSSFSTSSLHSTSSSFTPSSIASSSTSSTLLPFVSTSSFLSSTPPSSSSISHLRPPTSTQPSSPSPSASSTPHSSTLTSTTSPSFSSSSSSSSSSSSSSSSTSLLPSSTSTSFISRTPTSPSISSPSSASTSLPPSSTTSSVSSSPTFPSPSSASQSPTSPSSTPLSPPIPSSSSSISSSVSFTHALPSPVSPYSKHPSSAPHFSTLPSSTLPSSTSPSSSPPPSTSSTFSASPSFAPLFTTPSTFASPPSTSSSLPFTSPSHTITSTISVFTSQPPVTTSSSTPSSSLPPISSSPQFSSSSSSTTQSPGYNSPKILLSSSVPSTTTVGGQRTTSTIPTDLTVSASPTRLSLSSDVTTSTFPTGQSLSSDDTVSTSPPGQTLSSQPTTSAMFSTSQSGSVVTTSSYPPSQSLSSDITTSALPTGHSLSSGGTSSKLSISLSDITASTSSSDTTALTLSTGQGLSSDVTRTTFPGSKSLTSDQTASLASSVHSLSSGRTSSTPLSTGNPSSDPTVHTVSTSQTSSSILTTSPVSTIQTRHTTATQSIQTSFFTTSSTPRSSSGASVSDNTSISKVSHSPGTTTQNSDTNPDTTRIQNPDTTRTSQNQYNSRTSQYPLNSRSSQNPTNTRTTQRPRTSENPTNARTSGIVTNIRTSEALTNTGTSESPVDVRTLETLFNTRTSDNSLNTKTTESVPQPVTATSSSEATTTLQGATVLETTHQGLATFSPPTSPPTQSPVTGTPSQPPVIPGLTNSNALGVRKQYPVCIIQVNGCNGKKKNVSPGVNIASRFSFSDTMLDLRGDDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWA7</accession>
    <name>A0ABM1VWA7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101850018</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826699.1">
        <property type="nucleotide sequence ID" value="XM_035970806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850018"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="36"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826699.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38285" checksum="7CD07F880AE9C0B0" modified="2025-10-08" version="1">MSLPEQGGLVSAELARAFVVVNLVVLSQVVCVFGIGANIFNMIIFKRHGFKDTVNVSLFAMAIGDLGALVTQQWFIICVNPWFQDLDIPFSSTEVQSLTAGYPHRYFVKSTAWITAFVTFERCLCVVLPFKVKSLITRKVSFVFNVGVYVFMTLTMIPLYTTTYFCWKFYPARNRTLLGITFTSDSKETLSKWLFLSDFVVPLIAFIIVLFCTLITAAKLKSKAKWRRKTAAPGSSLTSGEISSKDRRVVVMIVIIAGIFILCSTPISAISLARSIEPEVNIIGRYANLNWLCASLGMLAETVNSSINALVYYKMSSRYRDTLGQMFSPCSLWWRNDNNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWW7</accession>
    <name>A0ABM1VWW7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC118478069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826909.1">
        <property type="nucleotide sequence ID" value="XM_035971016.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478069"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836:SF13">
        <property type="entry name" value="PROTEIN CRUMBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836">
        <property type="entry name" value="SLIT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DSL" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035826909.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14801" checksum="3F2854A279574339" modified="2025-10-08" version="1">MFYYGNQCDRYCKARDDERGHYRCNPVTGEKICLFGWGSDDCLTNLDDCNGHRCHDGATCMDHIGYYTCKCPPGRTGVYCDGEINECASSPCHNGGTCVDESNGFTCECPEGWAGLLCEIKIVPCKVDNCVHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYL3</accession>
    <name>A0ABM1VYL3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012713</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827506.1">
        <property type="nucleotide sequence ID" value="XM_035971613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012713"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045860976" evidence="2">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827506.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36544" checksum="8E8794CBAF5A5F0E" modified="2025-10-08" version="1">MALPVQVILLTAIGVSDAARKKALLLHYTGEEVFDKYETFSAAQKGSDTEAGYNMLCQSFTTHFAPQKNIDYETFKFRQARQEAGENIDSFCTRLRKLAATCDFQDSDRELKSQILQGCTSQRLRRRALRDDLDLQNLLKAARALEISDEQAQEIEADRKPATVYNISKQHAAKGKASRFPSATHRLYPPSQPSHRRYQQTHENRPCGWCGGLRHPRDRCPAKDKTCKTCSKLGHFSKVCRSGNKPSTHCRHSTAHVKHVTSNLNESSDTSEEDYVFGVKTNQMTPQCDNHTYSFCNSLCSESPELFKGLGKLKGIKVTLHQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYQ0</accession>
    <name>A0ABM1VYQ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC118477131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC118477131</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035827543.1">
        <property type="nucleotide sequence ID" value="XM_035971650.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477131"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="FOG"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="InterPro" id="IPR034731">
        <property type="entry name" value="Znf_CCHC_FOG"/>
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    <dbReference type="PANTHER" id="PTHR12958">
        <property type="entry name" value="FRIEND OF GATA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN USH"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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        <property type="entry name" value="ZF_CCHC_FOG"/>
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    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
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            <begin position="109"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2L2</accession>
    <name>A0ABM1W2L2_APLCA</name>
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        <submittedName>
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        <name evidence="3" type="primary">LOC101849090</name>
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        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828905.1">
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        <property type="component" value="Unplaced"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="RefSeq" id="XP_035828905.1"/>
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    <sequence length="830" mass="95204" checksum="F866693C68425699" modified="2025-10-08" version="1">MGCGLSSERHERVKVTQMPGCFMATYQLQPNYAYSQGHALYVEDHKQVEVLPRPSPPPTNKGDIFHIDKYRVLDKRADKAPSKYLREPYSALMGYLLTGVYDDLSKIRVIYRWVTSLKMERILLPKVEPPATTPLFQIWRIKNRKGNYAQLISILCRLANIPCAIIHGRLKGSTYDVGQKVHDRLHYGEWNAVLIDSYWRLLNAYWGACAIGSEGSDDWLEIDDGGEDESEKKADGKFATKEYVYVCDENYFLTDPRQLITTHLPFSKEWQLLSEPITLERFERMAFLKDRFFNLGMSVITHSDCVIGSQSGEVEICFGMPPDAARYYKFYYLLFRQENKDTGGVSPKYDRYVFMHRPKKDELTIRIRSPVTGTFRLELVGRDTRIKDPTYDYDWIALYKIRFFKAKDKCLPFPNMPDLGWGPGQYATQLGLSALSHCSGEVKASWCGEAEISFEVCDYNRMGNPMFYGRLSRSGTKEERLKDRVVHRVENGRVIFNVKLPKRGEYSLSLDGTSGKKPTPRNFANYMVVSDQRPSQAGYPRGFDEGIGKKPACDRFDIVPISHKSGLIYVKQDEFELCFKTPLGTELSLSVIGSDVMVSDSRRLVSETVEGDMMKYKIRLPKEGTYGLKVGLTVRRDLLGAIRDRALDELVNAITLVKERGYEHRMVSELREATKMMERLQHIQDLLHDVQTMSQKTITEIRGYSSPPPAVHRVMMATLLLLGHFEEETQVCLSDWLKLQAIIGKTGRDSIKKRCEELNLDDVPLDIALGARHLLKDYTLDQCRMVSSGAATFYVWAKCIIDEISKRYAEEVAHTRPRTSRSRRGNRQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2X6</accession>
    <name>A0ABM1W2X6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 2D26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101855607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829019.1">
        <property type="nucleotide sequence ID" value="XM_035973126.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855607"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046214877" evidence="8">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035829019.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="58459" checksum="6B20D87ED9347E44" modified="2025-10-08" version="1">MISEYLIALVVLAAIFLIGSKIKNRKPTTVPGPSILQGLWDFLQSMRHDSLHLTAAKWADQYGDIVSVNTLLRQVVFVNSSRLARKLVCDPSTREVSNDRPPTFMGRVFFYDSQDILLGRYGKDLFKRRKIFHQVLKFYGQGVHNFETLMKSTSKELCHRLTQYEGDIPISIELARYIRWVVALLLKGPETCEQDLDAMLEYIDRTNECFIFEKEVVLETVPFAPHIPGLGLKKLVGDLKVAQEVMRQRFFLAIRETYQKGERTGIVTDMLDQQTELKEKGNASEMPDELIIGLVQDIAAAAYATTVATLKTLFLQIVVDQKLQDRIHAEICEVIGDESPSFEHKRHMPYTEAAILETLRYSSVVPLLLPHYACGDIHFEGHFIPKGTFLILNAFYFHHRDDAFEDPWKFKPERFLDSEGQLLDPEHPTRQKLIPFGTGKRACPGESFARIRVFFIVVTLLQKYRFLPPVDDPLPSVHPRDWKIQAVISPDEYKCRMEPRLKGEAGTCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3D6</accession>
    <name>A0ABM1W3D6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Muscle M-line assembly protein unc-89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829179.1">
        <property type="nucleotide sequence ID" value="XM_035973286.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855990"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="415"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="524"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="657"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="762"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="960"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1263"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1382"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1537"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1651"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1804"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1917"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="850"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1158"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1493"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="862"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1183"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1236"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829179.1"/>
        </source>
    </evidence>
    <sequence length="2042" mass="222359" checksum="12CB0F3E450C573D" modified="2025-10-08" version="1">MPAGTDHYVGGTKHFECRVKGHPRPNIRWFKDGTEITDNPRYKFDHTHEGVISMVIENIIHDDEGHYRCRAENSEGLASTSAYLFVRAHKEHPEESHTSIHAMEIEEVVLAGKSLRGASTKSAEPHFQTPIEDVDESHSKVRRLSAEEEEVVRKSFEQVIESAESTRVISSSVKTKVEQDSQKISADLREKSYHSSDDSGDDVDSVKLKTISERSETSIHDSLCDFASDGERSLLMEQTSRIFSEELGLNGEVKTSASYESMSSKSESSMVVKKETKDGKTISSTVESSSSSFSSSSKTEVRSTKSVGQKTVAVSKEEVEEESYTESETGSEVGSVVGVDQARKKVTKQDSKEKDETDGTTRGRDISGLLDDDKTQEVVEQRSSWVEQVSTETQAEKTETVTEESQAARAKEEKPRLVQTPEKMEVQAGKTLKLRSTIEGSPNPQVSWSRDGRSLQAGERITMVTENDVYTLEIRETGPEDAGTYRLTARNSVGEIFTDIPVTVTGSSPSEDGRLDLTASVNIPRFVMQPQDVSVSEFETIKLVCTVRGEPNPSISWEKDGKKLRANRRMRLYESRGSHYLEIPEAEADDAGEYVCTAVNSHGTVSATVHVTIEGMESIISTSELADEQGAMAAAAPLDVTDSSDVAKKAAKVSEKPKVVTKVENVETEAGGLIRLTVKVEGNPKPDITWTKSGVKLRDGGRVVIRSEGDLYILEIKNATSADAGTYRATALNMEGETYTDIPVSVSSPSKEPSVEVDPNFPRFEEMPKDLIVAEREDINLTCVIKGDPLPNVKWEKDGRRVRSGRRIRVYESRGSYCLEIREGEVQDSGEYVCTATNYHGSVKHTVKVNVGGPIPTAGEKPPSDLPKEEVPAPAKTEEQPSEPIKEEITPEAEPATEEIPPAPEKETTAPGGKTDAETASSKPAEEDLTAKSKTDLEEPPQKVEENEEEKEEVIVQTKPKLVKTVEDVKATSGGKVTLSTSIEGTPKPTITWSKGGKTIPDSGRFSVTCEGDVYTLAINDATEADSGTYRITAHSSAGETYTDINVNVSPAETKKPEPTVEVDPNFPRFEEAPSDVAVRELEEIKLVCAIKGDPLPNVKWEKDGRRVRSGRRIRVYESRGSYCLEIRESEAQDSGEYVCTATNYHGSVKHTVKVNVGGPVPTAAADEEPPSEPATEQIEAPAKAEEPKPEPVEGAIKPEAKPETEKPAEEITTPHGKTDTEQPAAEPAEVSPKSKPVEEEPVEKTPEQKEDKKEEIVEQTKPKLVKTMEDVKITAGGTVTLSVSFEGEHPLDFCYWNRTPKPTISWSSGGKAITDDGRFSIRCEGDVYTLEIMNATEADSGTYRVTALSSAGETCTDIQVEVAAAEVKKQQPSLEVDPHTPRFEVAPTDVAIGEFEDIKLVCSVQGDPAPTVTWEKDGRRVRSSRRVRLYESRGSYYLEIPDSEAQDSGEYVCTATNSHGTVTHTVKVQVGDIQTSTTTTEEAQETGVLTVEADSEISSSQTTEEKTSTETISSVEVEESQSRDVTAEVTQVESKPTVVQKPENIKTEAGISLTISTTIEGTPKSEVKWSKGGEKIKDGGRFSISSDSDVHTLEIKDATEADTGTYRVTALSSVGETHTDIEVAVAAPVSSQSTEITEATPSVEVDPHVPRFEVSPQNVTVAEFDAVKLVCAAKGDPAPTVTWEKDGRRVRSSRRVRLYESRGSYYLEIPDSEAQDSGEYVCTATNSHGTVTHTVKVQVGDVATSSSALTEDTASLEVQADSEISSSLAAEEKTSLEASASVDVEESQVTQLSAEVTEVESKPKFVDKLEDVKIEAGSSIKISTTIEGTPKPEVTWSKDDKVIKDGGRFSVTSETDTYSLEIREATESDSGSYKVTALSSVGESSSTFEVSVAAADVSVEEVKKPKPSEEVDPRIPRFGVEPQNVTVAEFESVKLVCEVKGDPAPTVTWEKDGRRVRSSRRVRLYESRGSYYLEIPDSEAQDSGEYVCTATNSHGTITHTVKVQVGDVATSSSALTEDTESLEVQAGSEISSSLVSKLYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W409</accession>
    <name>A0ABM1W409_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118478960</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829402.1">
        <property type="nucleotide sequence ID" value="XM_035973509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478960"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045353008" evidence="2">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829402.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12528" checksum="87995080ED05B1AB" modified="2025-10-08" version="1">MPLSNGYIHQTPRTYPSLVLAIVLLFFFNCPCQCADPRQQIEAPDDPYGAVQDLNMDVIGADESVEEFVYGNLKDWISQELRKMCSSDGNRSTDDREDDVFNMEADSSNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4I9</accession>
    <name>A0ABM1W4I9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118477132</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829582.1">
        <property type="nucleotide sequence ID" value="XM_035973689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477132"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829582.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13333" checksum="23D9261B921371F5" modified="2025-10-08" version="1">MQMRSVKLLRCNLHSRNQQWRLTDDGQLMSGEFVIGLSLATKNSPQQFKIFKLSKASNVKTLWRYDHHRRLVHEQTGKCMQANPRTKAVTLETCIMRDMQTWTLTTREERQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A1KYB6</accession>
    <name>A1KYB6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytoplasmic FMR1-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100533349</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2006" name="Cell" volume="127" first="1453" last="1467">
            <title>Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Edwards J.R."/>
                <person name="Puthanveettil S.V."/>
                <person name="Kohn A.B."/>
                <person name="Ha T."/>
                <person name="Heyland A."/>
                <person name="Knudsen B."/>
                <person name="Sahni A."/>
                <person name="Yu F."/>
                <person name="Liu L."/>
                <person name="Jezzini S."/>
                <person name="Lovell P."/>
                <person name="Iannucculli W."/>
                <person name="Chen M."/>
                <person name="Nguyen T."/>
                <person name="Sheng H."/>
                <person name="Shaw R."/>
                <person name="Kalachikov S."/>
                <person name="Panchin Y.V."/>
                <person name="Farmerie W."/>
                <person name="Russo J.J."/>
                <person name="Ju J."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="17190607"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.09.052"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CYFIP family.</text>
    </comment>
    <dbReference type="EMBL" id="AY687629">
        <property type="protein sequence ID" value="AAU05773.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191572.1">
        <property type="nucleotide sequence ID" value="NM_001204643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1KYB6"/>
    <dbReference type="GeneID" id="100533349"/>
    <dbReference type="OrthoDB" id="10265867at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008153">
        <property type="entry name" value="FMR1_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01698">
        <property type="entry name" value="CYTOFMRPINTP"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="4">
        <location>
            <begin position="81"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAU05773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="NP_001191572.1"/>
        </source>
    </evidence>
    <sequence length="1259" mass="145773" checksum="32248D68CD3676EF" modified="2007-02-06" version="1">MSGEEKVTLTNALENVDVLDDLPLPDQQPCIEALSLSVHYRANFDTNSEDKNALVTGVAKYMEQATVQADLDLLLEKGEECAVMLYTWRCCSRAIPQVKSNEQENRTEIYQKTVEVLEPHVNKLMQFMFFQKKAIDLFCEEVKRLCHKEKRTDFVSEAYLLTLGKLINMFAELDGLKNMKASVRNDYSAYRRAAQFLKVMSDQQAMQDSQNLSMNLATQNKIRDTLKSRLAEIPGYDELLADVVNICLMMCDRDMYLEPSEKHMLVKVMAFGLFLMDMEKGPNIYRMNDKKRINLARIDKILKQLEMVPLYGDMMIAPYNYIKNGPNYDSSKWPACESSQLSPQSNLLGSLEMIRERHMHYISQLARHNNEVTTTMREVPRSDQENRELTELALRGLQLLSKWTQQVMELYSWKLMNPTDPHANKDCPETAEEYERATRYNYSRDEKFALIEVIAMIKGLQLLMARMETVFMDAIRRHIYTELQEFVQHTLREPLRKASKKKTEIIRVIIMSVRSTCVDWMRGTEPQDDPALSGKKDPSDGFKIKVPRRNVGPSSTQLYMVRTMLESLVDERGGGKKSLRREMDEHHVQAIEEFHRKSFFWNYLLNFNASLFNCCDLSQLWYREFFLELTMGKRIQFPIEMSMPWILTDHILETKEPSMMEYILYPLDLYNDSAQYALMRFRKQFLYDEVEAEVNLCFDQFVYKLGDQIFAYYKHLAGSIMLDKRFRAECMSSGEKINYPVANRYQTLLKQRHVQLLGRSIDLNRLISQLVNAALQKALDIAISRFEAGDITGIVELEGLVEVNRLAHKLMGEYLVLNDFDAMLKEANHNVSAPYGRITLHVFWELNMDLLPSYCYNGSTNRFVKTKIAFGKETKREKPPNPSVHYIWGTKRLNHSFSTIFSLYSGFVGAPHFRAICRLLGYQGIAVVIEELLKTVESFVKGTTADYVTTLMKVMPEQCKLLRFDYGSPGVMGYYQAQLIDLIQYTDLRTGVFQSFREIGNAVLFCLLMEQALTQEEVYDLKHAAPFQNVIPKPYIPAREGRDRETEAKSVMKQLEKKYAALQVVSVIKKLGNKAQAHIASDGDLLTRERLCCGLSIFEIVLKRIESFLTSPVWHGPAPANGVMNVDTCTEFHRLWSAIQFFYCIPVGEHEYTIEELYGEGLNWAGCTLIMLLGQQRRFEALDFCYHLHKVNRVDMKDENIKGIQLKKMVERIRKFQILNNQIFSVLNKYLRSTDSEAMPTEHVRCFPPPIHQSLATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAH2</accession>
    <name>A0ABM0JAH2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">All-trans-retinol 13,14-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101863939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089177.1">
        <property type="nucleotide sequence ID" value="XM_005089120.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863939"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052206">
        <property type="entry name" value="Retinol_saturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091:SF3">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091">
        <property type="entry name" value="BLR7054 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089177.1"/>
        </source>
    </evidence>
    <sequence length="636" mass="71350" checksum="7635B89E7172EDEB" modified="2025-10-08" version="1">MSIDIGMRDVFDFLLSHPSILIVGFLLYVFVFFLSVFFRGQKAGKNPFATDYRRPPEPFVHDTKARDAVLKQKFKTSKVPEKLDAIVIGSGIGGLTTGVLLSRVGKKVLVLEQHDQAGGCCHSFVEKGFEFDTGIHYIGNVHEGSDNKSLLDQLTGGQLRWNKMDDAFDTVAIGPPSKAKMYKMVSGKERYIQNLKDMFPKDTEAIDQYINLIYDASKSFLGIVMLKAMPKLLVRFLVMSGLYKLVFACWRKGYTEKTLQEVLDGLTSNKELKVVLSYICGDYGVVPKDVPFLMHSVLITHYISGAYYPVAGTSEIAFYMCDVIQKHGGRVLVQAPVTNILCNDKGRAVGVRVGGKSEVDLHARYIISDAGAVNTFKTLLPQEIAQKSCIYPLIEKIGPSFSFITAFMGVEGTSKELNLPAGNYWLYNTLDINKTLSEFLSLKAEDLEDAEIPFGYISVPSAKDPEYEAKYPGKSSVLVITLANWEWFKEWKDEKLRHRGERYEGIKDVIGRRLWQQCVDIFPQLEGKRVYMEVGTPVTNSHYLACPEGEMYGLDQGKARFTADVASKLRPDTDIPGLYLTGQDTMTCGFSSALMMGLICASQILHRNLYNDLQNMKKKLYPRTPSTKTDQMKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JB79</accession>
    <name>A0ABM0JB79_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="4">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12" type="primary">LOC101848560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005089657.1">
        <property type="nucleotide sequence ID" value="XM_005089600.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089658.1">
        <property type="nucleotide sequence ID" value="XM_005089601.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089660.1">
        <property type="nucleotide sequence ID" value="XM_005089603.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825331.1">
        <property type="nucleotide sequence ID" value="XM_035969438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848560"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="7">
        <location>
            <begin position="89"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="6">
        <location>
            <begin position="390"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005089658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005089660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035825331.1"/>
        </source>
    </evidence>
    <sequence length="740" mass="84242" checksum="570448F4C9B0F56E" modified="2025-10-08" version="1">MPYQYKNDMRRNRGGPYKTKPATDLTRWRLTNTEGRQVWQYFTKEEDLPREQTCLEKHSLGLDTSAEAPPLPKAEKAQDAAKNGMTFYSKMQAEDGHWAGDYGGPLFLMPGLIIVCYITKTPFTEAQRVEMIRYLKSVTCPDGGWGLHIEGPPTVFGCALNYAALRMLGLPADDPDLVRARDLLHKLGGASAIPSWGKFWLAVLNCYSWEGLNSLFPEMWILPTWLPFHPSKLWCHCRQVYLPMAYCFGRRISAPEDDLIRSLRKELFVEDFDKINWPAQRNNVSSADLYSPHAIILDIAYTILNIYEKVHLGFLRKWALADMYDHISADDRFTKCISIGPISKVINMVIRYHEEGPTSKAFMLHQDRVQDYLWIGLDGMKMTGTNGSQSWDTSFAATAFLEAGAYKYEELKKCLTACHDFLRITQVPENPPDYKKYYRQRNEGAFPFSTRDCGWIVSDCTAEGLKAVIKLEEKCQITEAVPKQRIYRGIDVLLEMRCDDNGWATYEDKRGGVLLEVLNASEVFGDIMIDYTYVECTSACMQCMTTFTKAHPEYRKDEIQAALTGGLDYVRGKQRPDGSWEGSWAVCFTYGAWFALEAYACMGHVYGGGEGQDSGKVPEEVEKGCQYLLSIQMEDGGWGENFESCEKRQYVPSETSQIINTCWALLALMAVKYPDVEVLEKGIKLIMSRQLENGDWPQENISGVFNKSCAISYTSYRNVFPIWTLGRFANYYPQSSLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBC3</accession>
    <name>A0ABM0JBC3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Solute carrier family 22 member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101848253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005089749.1">
        <property type="nucleotide sequence ID" value="XM_005089692.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937668.1">
        <property type="nucleotide sequence ID" value="XM_013082214.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848253"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012937668.1"/>
        </source>
    </evidence>
    <sequence length="646" mass="71673" checksum="887170153FFA519B" modified="2025-10-08" version="1">MDVDLIQLKLVENYRFQILSFIALGIVYARGAWNVFGVLFLAAGAGHTCDYDREIVTVESKDSNQHVTTIFNASSNFTVTTVSWGLDGKKSKDPLIVPRECDVIVAGENGTNLSMPCTFGWVYRSEFESTIVSEWDLVCVRAYLSELSTTLYMVGSMVGAFLISPLSDKFGRRIVLLLCLMAQAVVGACVALSPNYAVFTTLRFIVGFFNMGIALCTYVMMTEIFPAQHRAIPSCGFQIFWAFGVMLTALFGFVVRDWRHLQLVFSLPNILCAVFVWIMPESLPWLISQNKLSKAQSVIARIARFNNLDIPDDFYMYEASQVNSTNDQEDIQCNSPSSRCADQPLLSEELSQQEAVGLLSEGSSHELRDREAVADKQNGHAQAGDDTSQTGRVTTPERIVDSPAIDPEVQIIAESTPGNAGFQQSTRISRTRELKNVFTLCTSPRIRLYTIIMFFLFFVNSLSYFGISLSTPVLHGNQFFNLFLLGAVEIPAYVICILVCERVGRKVPLCVFLLTCGVMNITAMMISDEASSGMSGVKIGFVMLGKFAITGAYTTVYLYSAEIFPTCIRNHAVGISSCFENFGSIAAPFIVFSAKSHPEFPMILFGIVSVIGGLMTLFMPETHRRPLPQTIEEVESWGICKRRRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBR6</accession>
    <name>A0ABM0JBR6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcipressin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090013.1">
        <property type="nucleotide sequence ID" value="XM_005089956.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845206"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12434">
        <property type="entry name" value="RRM_RCAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090013.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24146" checksum="3864AFD70B95ECA1" modified="2025-10-08" version="1">MSERMDSVESMDDVDHLCEEMDGLTEMTDLDDIPTALIITNIDSNIFEDAHTQEMFEHVFRDLDKDVSFIYLRNFRRARVQFSSSDFAAIARIRYDGVAICGSTIRCFFLKVHQPSTDNTHLQPPQPQRMFLISPPASPPVGWEPIPESEPVINYDLLHAIARLNPGETHEVHPPSGEAPAIVVHLCEDPEGTQPEFKPQIIQTKRPPQMGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDW8</accession>
    <name>A0ABM0JDW8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101845824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091443.1">
        <property type="nucleotide sequence ID" value="XM_005091386.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845824"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046607125" description="Glutathione peroxidase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005091443.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25673" checksum="108DBFA5525F6FDB" modified="2025-10-08" version="1">MKCTIFLFQHLLCLSFLLFISVTSNKNEDSISFSHLDEEIPEEFDFYSFFAVDIDDNIVSFERYRGQVTLVVNVASECGYTDNHYKSLNLLNQLFRETGKFNILAFPCNQFGGQEPGTLREIHNFAYNSMGATFLLFSKINVIGQDVPPSWNYLIQQSGQPPTWNFWKYLVDHQGKVIGAWGPTVSPDQIYQYIDNAINKIGKEDAEKEEAKQQETKTTKDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEU3</accession>
    <name>A0ABM0JEU3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LYR motif-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092109.1">
        <property type="nucleotide sequence ID" value="XM_005092052.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859548"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005092109.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10334" checksum="90FD4BAFBF85C475" modified="2025-10-08" version="1">MAASTRTKVLSLYKELLKESKRVTDYNFRNYALRRTRDAFKENKAITDAGQIQALVVKAQENLEMLRRQATVSQLFGSEKLIIESQPKGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF57</accession>
    <name>A0ABM0JF57_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC101862780</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC101862780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092294.1">
        <property type="nucleotide sequence ID" value="XM_005092237.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005092295.1">
        <property type="nucleotide sequence ID" value="XM_005092238.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005092296.1">
        <property type="nucleotide sequence ID" value="XM_005092239.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862780"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021075" evidence="2">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005092294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005092296.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23621" checksum="145B03267A543964" modified="2025-10-08" version="1">MFLLRNLGAHVILVAFLVCRVGTVHMDWPGSGPVSSEDDDDSDGSSDPDSKVSSGEVGHQYVNQEAQLDSEDSSENDNSTHAVGLLANPFVDVEDSHVNDEIESKKEKEKEKVVPLCPTDEVMNVSVVCTHHNELHLHCVDKGSDVCACSSDSRCKEAHEGSSALCLFVCLPSPDVPDDLGNYFYQVFRHVINKGEGKSSVKKDSDEKDKDEEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFL3</accession>
    <name>A0ABM0JFL3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RUN and FYVE domain-containing protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101861716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092554.1">
        <property type="nucleotide sequence ID" value="XM_005092497.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861716"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15721">
        <property type="entry name" value="FYVE_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17681">
        <property type="entry name" value="RUN_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF6">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="9">
        <location>
            <begin position="98"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="596"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="365"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="512"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005092554.1"/>
        </source>
    </evidence>
    <sequence length="661" mass="75215" checksum="62CF42699031D951" modified="2025-10-08" version="1">MDAPTEETGGGKSLFDELSEVTSKPADNDEWPTAVRADERTTANLCAPGKNERENLPSRHRKERRDPKTIERANLMNVSKLLIKELIDSSLAHGRMLDDDYIPLQQFFIVLEHVLRHGLKPKKGILSSKKEFWWVLETVEKIAPEAAEITTSVREMPNIRTPLGRARAWLRLALMQKSLADYFKLMIEQKDRLLQDFYEPGAFMLEEEGVVIAGLLVGLNVLDCNMCIKGEDLDQPMGVIDFSLYMKDGKYSDSTDDDNGEGNSKMATILDQKNYLEELNRHLNATVANLQQKLEQVQADNCLMKEDLAISKNSILTLQAEVDELSSEKENVTTGYQKQMEAAKQDIDAERATYITSRAGLDTMYADVKKQLEDETKLRLDVEKELELQIGMKTEMEMALRLLEKDIHEKQDTVIGLRKQLDDIKAINLELYNKLQACESTVKHKTEMVTKLEEKTNQLVGAMKEMEQRLKQSASDKVAAEETARKLGQIIAEKDQKRSALETSLQIERDTRGRVQSDLEQEREKLAQTQLEVAQLKDLKRDYSELIGRHEELQAQCTEQESALAELGSHLSESKLKVEDMREASALQREAHWASDETATHCKQCSKEFSLARRKHHCRNCGDIYCSECSDNKMPLPSSSKPVRVCDTCNEQLLHRYSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFT4</accession>
    <name>A0ABM0JFT4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101856407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Integrator subunit 14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092704.1">
        <property type="nucleotide sequence ID" value="XM_005092647.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856407"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039841">
        <property type="entry name" value="INTS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045814">
        <property type="entry name" value="IntS14_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046471">
        <property type="entry name" value="IntS14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532:SF3">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19435">
        <property type="entry name" value="IntS14_b-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20504">
        <property type="entry name" value="IntS14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 beta-barrel" evidence="7">
        <location>
            <begin position="210"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 C-terminal" evidence="8">
        <location>
            <begin position="407"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005092704.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="57635" checksum="F2E4207D4827D057" modified="2025-10-08" version="1">MPTVIAFDVSLSMVRPVVLPDVSEEYQRRHLAIHGINTFLDYLSGNYKLEFVSLITFSYLWEHLVAFTRDFDSIKAALNKVEVFSKTCIETALNGVKTIISDEWNNTMCQVILVTDGSLGIGAGSLKKSLQTAGNRSSTEEKFPLPFPFPCKLHVVCIGNPSNPDVRHSLFYYQKLIDIGGQGGELFTLDGPITFKSVSDVFMRLCEKYYNPFCGTLVCGNFNCSVQLFPHPEPLVKQLDDCQETYSVSEKLEIVGFIDIKDVGSPPTIARHLILPRSIREKAADAKDKENKNGKEEEEDSQEDGKVPSFTVLLHGSLKVESMVALTRIQDNWYGMIYSWADNKKKSNLIIAMFEPGQNSIPWLGSFDNLTSCKEYLPDMVYSDEEKKSPFPVFPSDKRSYSLPCIVWIKPSGLQSDLQKVLRHAKKLPDKLQQFYKELNRTRRAALYYGFHILLEAMAAILERECTLLPGTAHPNAAIQLTHAANALRYETALDVNHTIMPLQTNFASGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGJ6</accession>
    <name>A0ABM0JGJ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850634</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093193.1">
        <property type="nucleotide sequence ID" value="XM_005093136.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850634"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005093193.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14842" checksum="19C07EBDF4CF833A" modified="2025-10-08" version="1">MPREDEKRRERSRSKGKGSRKSSHSKRSRSSSRGAIHKTMSASRTRASVHKLISGAPMNAVLGTAFGSGVAAKMLQGREYKTGQWTAVGEDSNPCKKELDDFVSLASNQLTEATTCVKAIEHLKKCVLTNPAYFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGX2</accession>
    <name>A0ABM0JGX2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101862015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093418.1">
        <property type="nucleotide sequence ID" value="XM_005093361.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862015"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005093418.1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10403" checksum="2390791434061F08" modified="2025-10-08" version="1">MAGQVPPQMQVDAMSSGAQFREFLSQYNKITEQCFMACVHDFTTRRVISAEDTCSINCLEKFMKMTNRISQRFQEHQMASNDSLAALAQQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHR3</accession>
    <name>A0ABM0JHR3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="5">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005093926.2">
        <property type="nucleotide sequence ID" value="XM_005093869.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857010"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="222"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005093926.2"/>
        </source>
    </evidence>
    <sequence length="350" mass="39787" checksum="BECAEA20E7CA6068" modified="2025-10-08" version="1">MAAPLMRQLFLRRRSRQSQSYAVRFFAVRGSGAHGESETDQDRQTETHFGFQSVPEEEKEQKVHEVFSNVAKTYDLMNDVMSGGLHRVWKDVFMDRFSPAPGTKLLDVAGGTGDIAQRFLKYVRSPTHIDLDSDLSADIELPRDITAQVYMDPAEDTTDWSSSSSSDEEERRKNSSSRYIQRPDQNGSHVTVSDINQDMLDVGREKLLQLGYNAGISWFQGNAESLPFSDGEFDAYTIAFGIRNCTHVQQVINEAYRVLKPGGRFMCLEFSEVPNPLLRSVYDSYSFQVIPVMGQVIASDWKSYQYLVESIRRFPNQKDFANMIKAAGFRMVRYENLTFGVVAIHSGFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIE9</accession>
    <name>A0ABM0JIE9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC101852461</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:75539"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes glycerol monoesters of long-chain fatty acids.</text>
            <dbReference type="EC" id="3.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005094356.1">
        <property type="nucleotide sequence ID" value="XM_005094299.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012935700.1">
        <property type="nucleotide sequence ID" value="XM_013080246.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012935701.1">
        <property type="nucleotide sequence ID" value="XM_013080247.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852461"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="285"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012935700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012935701.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="64549" checksum="6AC6123990596DC8" modified="2025-10-08" version="1">MLRRQRKRVAPLDGSITVEVREGRHLRVQHFNACPRDAKFENEMQLYIQYRQTGIRSSGPLVMSRKPVSNLKRKSVDCGDERLQNSHPNFIQDKNEMCSGKKTIGLDKVAACATDDAVVSLKRDPESPKSGTRILDSASLSSSVFSSPSHQTASEHVRSASSVQLALHVKNQQQQQQTLIQKIQTSLPADIAETESESKDQNSWTNVPESTKENVGDGLAQDNIVALSSTGPFTLEAMTNQVSVHSTSVNSQSHKTGQDPQPPAPEDGANNVDSVEPTVHKDLALFFIHGVGGSSDIWCAQTKYFSDLGFEVILPDLIGHGFSGTPKQAKAYHFKEIAADLESLFDKYCKRKNVVIGHSYGASFASHLGRYRPRRVSKLILISGGPPTPLAPQPGVFSLPTCLLTCISPCLRRGFYKGAFHNKRTPVLPKEEAFNIPTYVLQNTMNGQDWPEGDEIFHNWLTCPCLLVYGSEDKLVSLKEEQEMAETIFDSHLEVIQDASHMVMMEAPDDVNQLIHAFILQSSSLVSPTARNNNATTNASISDTPREPPPPLSQRSKSRLSQRSLKSGKGQRSLPHNLLSKSFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ58</accession>
    <name>A0ABM0JJ58_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2 R2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101864515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094850.1">
        <property type="nucleotide sequence ID" value="XM_005094793.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864515"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23803">
        <property type="entry name" value="UBCc_UBE2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005094850.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26712" checksum="8356ECE77A999EE6" modified="2025-10-08" version="1">MASSPAGSAVKALQLELKKIQAEPVEGFRVKLVNDDNIFEWEVAIFGPPGTLYEGGYFKAHMKFPPDYPYSPPSVRFISKMWHPNVYENGEVCISILHPPVDDPQSGELPSERWNPTQTVRTILLSVISLLNEPNTFSPANVDASVMFRKWKESKGKEKEYENIIRKQVQATKEDAEKDQVTVPTTLQEYCVSSIPAHDNQVDADFYDDDYVDDVDDDEEMYHEEDEEDSGNEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJE0</accession>
    <name>A0ABM0JJE0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101861720</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101861720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095009.1">
        <property type="nucleotide sequence ID" value="XM_005094952.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861720"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005095009.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38226" checksum="0B777B5410DD23D6" modified="2025-10-08" version="1">MEDSKNKDPPKTCTRGTHEVEEQCAEAGGPLTSYTGCTKNPGHPQFIPVYEFNTDHVRSWTPDEGHQTADEIAGAVKCFAETVVRIRVPLISDQRPDTWADGRGYPFADRKGWRLNIAGSGFVVKVYGQHDGLEGPCKCDNCPKGTAEENKYWKILVVTARHVVYGDNEARACEVVFFDDQSDGSGSVTLTGGGAVEGGDTEEDGCELAWYTHNRKLAHRLKNLCNRRSEMLFRWFEETRVVVRSPRGKKRRLDVSPRSVSPATAVVISHPHGRMKYISLGNSDPDSLSDVKPYPFTYTVATCPGSSGGLVLPLGTHYYSFWFKPHSFSLSGNHGRSAGGFFYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJH1</accession>
    <name>A0ABM0JJH1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101855714</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101855714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095068.1">
        <property type="nucleotide sequence ID" value="XM_005095011.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855714"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005095068.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="13784" checksum="DB64091B7C523033" modified="2025-10-08" version="1">MNGIVDFNNCFVVGMQADSSDSHKYKGVARTFDLANLTTQDCCNVLLDSVKTEVAEKGEYPDSTLVPAAKPVCTGAADTTCSGDLGSPVYCKTTDSPSYDVLVAVVASSPCNSDTPLLLQDLTNGAIDNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKC0</accession>
    <name>A0ABM0JKC0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Cytosolic purine 5'-nucleotidase isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9" type="primary">LOC101849605</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095724.1">
        <property type="nucleotide sequence ID" value="XM_005095667.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095726.1">
        <property type="nucleotide sequence ID" value="XM_005095669.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824957.1">
        <property type="nucleotide sequence ID" value="XM_035969064.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824958.1">
        <property type="nucleotide sequence ID" value="XM_035969065.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849605"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07522">
        <property type="entry name" value="HAD_cN-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005095724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005095726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035824957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035824958.1"/>
        </source>
    </evidence>
    <sequence length="555" mass="63850" checksum="85BBF8AE6027F2EA" modified="2025-10-08" version="1">MADAAQNPAWSVSGGAAGTHMYKREPSKRVFVNRSLMLEKVKFFGFDMDYTLATYKSPEYETLGFDHLKSKLVDLGYPEDIKDFEYDSSFPIRGLWFDSHFGTLLKVDGFGNILVCVRGFHFMRMAEIQALYPTKFVQMEEGRYRIFNTLYELPLIYILACLIDYFNNSSDYVQTANGVGVKVGDLTMTYESIYNDVNTAMEHVHHPKGPLKTDTMSNVEKYVVKDDRLPLILTRLRDHDKKVFLATNSDYKYTNIIMNYLFDTKSNPEKKPWTDFFDFIVVDSKKPLFFSQGTVIREVNKDTGDLRLGTFTGKVRPGVVYSGGSSDMISEMMGTQRSEVLYVGDHIFGDILKSKKKQGWRTFLIVPEMVQELTVWTAESNLFSRLSFFDHQIAEMYRNLDSSDNSKPDITEIHKNIREVTHKMDQAYGKLGSVFRSGSRQTFFASQVMRYADLYAPSFSNMLHYPLTYCFRAPSMLMPHESTVDHDSTITEEQLREISRVWRSHVKEADKEKRNTLQRSDSNVPRLFCSSPRQLTEVADDFLDESVSGTDSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMI0</accession>
    <name>A0ABM0JMI0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101849455</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005097165.1">
        <property type="nucleotide sequence ID" value="XM_005097108.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849455"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="14">
        <location>
            <begin position="665"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="15">
        <location>
            <begin position="811"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005097165.1"/>
        </source>
    </evidence>
    <sequence length="955" mass="106635" checksum="764E56ED2AB6FDA2" modified="2025-10-08" version="1">MASIAEQPCYTLINVPMGAELPTELQLKTDLETGDARTKIEALKKVIQLILNGEKMPSLLMIIIRFVMPMQDHMVKKLLLVFWEVVPKYTPEGKLLQEFILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEPELLEPLMPAIRQCLEHRHSYVRRNAVLAIYTIYRNFEFLIPDAPELIHNFLEGEQDMSCKRNAFMMLIHADQERALDYLSSCIDQVTSFGDILQLVIVELIYKVCHANPGERARFIRCIYNLLNSSSPAVRYEAAGTLVTLSSAPTAIKAAASCYIELIVKESDNNVKLIVLDRLIALKEDLNHEKVLQDLVMDILRVLGSPDQEVRKKTLNLALDLTTSRNIEEMVLVLKKEVVKTNNVEHEDTGKYRQLLVRTLHQCSVKFPDVAATIIPVLMEFLGDTNELAAADVLVFIREAVQRFDQLRPLVIRKLLDVFGTIKSMKIHRAALWILGEYCTSSDDIQSVMTLVRQSLGDIPIVDDEIKKTAGEVKEDEMQMGGNVQRLVAADGTYVTQSAFSTTTVAKKEEVPPLRKDMMDGDFFIGAALATSLTKLALKFIAITQDKKRQNAFVAEAMLIMATIIHLGKSGLSTKPITDDDVDRIAVCLRVLAERSDMMNEIFNTACRGSLSLMLAAKIEEEKQLQQAAGRKEVKVHADDPISFAQLINRSDQAGGENVFELTLSQALGGNAKRDGDPLGASKLNKVTQLTGFSDPVYAEAYVNVNQFDIVLDVLIVNQTADTLQNLTLELATLGDLKLVEKPQPLTLAPHDFCNTKANVKVTSTENGIIFGNIVYDVSGAASDRNCVVLNDIHIDIMDYIVPASCTDTEFRQMWAEFEWENKVTVNTNISDLREYLEHVMSCTNLKCLTPEKALSGDCGFMAANMYARSIFGEDVLANLSIEKPFHLGKEAPVQGHVRIRAKSQGMALSMGDKINLSQKKALKTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNR4</accession>
    <name>A0ABM0JNR4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Muscarinic acetylcholine receptor M2 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Muscarinic acetylcholine receptor M2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC101861363</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097992.1">
        <property type="nucleotide sequence ID" value="XM_005097935.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005097993.1">
        <property type="nucleotide sequence ID" value="XM_005097936.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937766.1">
        <property type="nucleotide sequence ID" value="XM_013082312.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861363"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF224">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="57"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005097992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005097993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012937766.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="60028" checksum="D05F132596B50410" modified="2025-10-08" version="1">MAFETSTDGLIVDDDALNNVTDTERMAYLAELQEYTTRIMLPTIVLLVCFAVVGFFGNILVLIVYYRKVRGKSALVFIMAIAGFDLFTNMTAIPAEIYAMFHFWHFDAAHLCRARYFSTSVTIVSSACLLLVFSVDRYRKICRPFGRQLTVRQAKVLCVSITVFSSVASVPVLVLFGTMTRPTHRPDIVGNQCSIDDSFINTIWPTVYMGFLLFLFLSCFIPLVVLNVLVLIAACGRGRVRVFSISSPAHLHDNSENNSQSSTTSPETCDNASKARNESPSTSKEGSAFRSRLMGRVASQTGEMGMVFSRENDGSDKIGEGKLCGATEDTSDRKPKATDFCCSEHRKTKQVSVPSAKMVSFIQTSAQEDCIRPDPNSTNAEKDKGQITAVIPGTSKEQNIKKKNPAGEKTDMSVTNPNRKLKPRILQILTSEAKKKSPASTLGQPAQRHSIGKTTTKLIIVSAVYIISFIPFFSVMLFYLTSVAKFKTMDDVSLTLCNLFLRFYYLNSAANPVIYSLCDAVFWRDCLQLLKCKGKVRNTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPH4</accession>
    <name>A0ABM0JPH4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101859242</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005098492.1">
        <property type="nucleotide sequence ID" value="XM_005098435.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859242"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_005098492.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34739" checksum="83EDFA19DFF23B4D" modified="2025-10-08" version="1">MFRSAGIAEIIRSHQKDDSLLAFLRSTVTDIFQQVAGPRLWIQWRRYLDTSADVAYFALTSCSELQTIGEEYVSLIQTDSSLRSLPPLWRRLFMVFLQVLAPHLLTSALERFEQQLRHSSSFNIRSSSRETILGFLPLVRKAVTVLHRLHLAAFYINGVFYHLAKRISGIHYVQYMTKDRGASSVRPFQILGYLSIVQFAFSALLNLYSVVQAVKQQKKELKTFELESERRDQDSRIVKSNEKCPLCLSRRQHSTLTPCGHLFCWKCIHEWCQSKQECPLCRDQFPPHRMIPLQNYDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQA4</accession>
    <name>A0ABM0JQA4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of MON1-CCZ1 complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099020.2">
        <property type="nucleotide sequence ID" value="XM_005098963.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861284"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009755">
        <property type="entry name" value="RMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049040">
        <property type="entry name" value="RMC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07035">
        <property type="entry name" value="RMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21029">
        <property type="entry name" value="RMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator of MON1-CCZ1 complex N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Mic1" evidence="1">
        <location>
            <begin position="388"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099020.2"/>
        </source>
    </evidence>
    <sequence length="654" mass="74522" checksum="ACF00D91A9D939C2" modified="2025-10-08" version="1">MATGEDSYYITLCKNPVRFEPVSKANNVFFDDANKQVFAVRSGGAMGVVMKGPEEKTMASFRMEDRGDIISIKFSPDKRILAAQRSIKTVEFLNFQEDLSVEQQEYSQSCKGKTTEVRGFVWSSPNEIVLITSSGLEHYQVIPEKRTLKSLKSLSLQVNWYVWLSSSGLLLVSSGTLGNTLHPFQFRQPGVMTRLAKFEVDLPVIPKPQKLCLLDRDVTIAEIYDQLYIVILRHPPSAASGAEIVLYQLQKESPARKSDVLKLDMSGRFAINVVDNLVMVHHQASKTSVIFDIKLEAKSDGYVNYHYPVLSPLGIRPFKLLLPSVNMQAGTDKTEYNCELYSANWIVFQPDIVIDAKLGCLWTLQMNLNPLVTMIPDKDRLIQFLLYRTDSKGVVLSVCAQMLVPGSQASLQSLARVYDMLNLSYKQYLTTESQVMNGELASGSSSKRVVVDQSDMFTHVFSVFEEYKDIKYKFMVAVLIEYIRSLNQFGIPVQHYLYELIINILVHNNCFYQLHQFLQYHVLSDSKPLACLMLSLESVYPPAHQLALDMLKRIQTANEEIIEVLLSKQQLLPALRFIRSVGIVDTVSSRKFLEAALSTEDSRIFYTVFKFFEHRNQKLRTNPRFQTGEHCEDYVKHFEKTFGQDALMPIPTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQE2</accession>
    <name>A0ABM0JQE2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Haloacid dehalogenase-like hydrolase domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4" type="primary">LOC101861439</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099104.1">
        <property type="nucleotide sequence ID" value="XM_005099047.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099105.1">
        <property type="nucleotide sequence ID" value="XM_005099048.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099107.1">
        <property type="nucleotide sequence ID" value="XM_005099050.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861439"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16415">
        <property type="entry name" value="HAD_dREG-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005099104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099107.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28569" checksum="9C7C42FC03DAC90D" modified="2025-10-08" version="1">MARQLLKLVTVDVTNTLIRVAGSPGRQYAYVARKYGVDIDETLLTGIFLKEYKSYTKKYPNFGVMDGMPANIWWSLLVKDCFRFVDSKIPEEMLDKISFDLYFHFTKPMAWDLLPGAVAALEDLSQYPVKLGVISNWDHRLYKVLMVLKLRQFFDFILPSYIIGYEKPNSIIFHQALEDGRCEPHEAVHFGDNIEKDFIGAKNVGMNAYLLASEGVKNDFLDQSLVVKTVQEFVDKIRPQLGERKADPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQL2</accession>
    <name>A0ABM0JQL2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cofactor required for Sp1 transcriptional activation subunit 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101853165</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099239.1">
        <property type="nucleotide sequence ID" value="XM_005099182.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853165"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042376">
        <property type="entry name" value="MED26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031416">
        <property type="entry name" value="Med26_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15201">
        <property type="entry name" value="CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15201:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15693">
        <property type="entry name" value="Med26_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="426"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005099239.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="72328" checksum="7F9FF4DCCC9520CE" modified="2025-10-08" version="1">MPLTPAQIKDKLTNALDDDKNVVDEEAVEEVITLLETSSLTKEILEQTRLGRDINYVRKTSKIPATAKRARNLVKAWQRLFVVPGSPQVANGQHPNVSSSSLQRISPGLQRVSPGLSPAISRSNTPVRCAPSPALAQVRQQQRVAGSRSPAAQVSKLSQKLQRGSDSRSPAVLRSASNNHDDSNLSWPGTPPCPPCENSQDRLAGDRDSAKPDASGGSKNCQAGGTNERHFNFDHKSSDHSLESTSKLVNRASDQRDVSKTNVANRKRTRAETRLDDSESQTPSSKQVRLTSSSPSLSAPVFSKSDVINGTVLRKSGRKSPAASASTENLFVDHKTMVSSSNKGSLLDQPEPSTPLSRANKRLALQRQDSVSSRLSVQSTELRTRERTNKVKTTEQLIEDMQGKSTTPVGTQVIAQIRTNKIQQESDYLKPVLPPGVKRRGRKKKQEREQLELPDKESASDGRKLAQTKSEYIKRFLQTSVAPTPGEDIYEAPISQSRHESLEEQPIGLGGCSTTFAQSAYDSNFPSYPSRQDKSDSGPSASPPEARDILEGAAHHLPSSSCGVADVHAPSSERLSEEQILARLPPIDFDNIDWASHDYPSLQPMQVGSELVVRLHSENMEGVNGTYDRDGQFRQWAELLTVDSVYDEPLYILPYVIPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JST9</accession>
    <name>A0ABM0JST9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Four-domain proteases inhibitor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100683.1">
        <property type="nucleotide sequence ID" value="XM_005100626.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852327"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047118636" evidence="1">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100683.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16727" checksum="6E5EB5480DAE27A5" modified="2025-10-08" version="1">MKWVVLALVVAVSVDGAMSATCDSLPPQTCTGEGVPVCATFIKTFPTACVLESQKCELAKQGFEFVYVLIGAMMPGDSLDFNRFIFRTIHNEGDCCTTRAMTKELSYRCGTDGNVYGNLGKMKLAGCQTRDYIKEQYPVNCPDFPEGLIIIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSW4</accession>
    <name>A0ABM0JSW4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deleted in malignant brain tumors 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101863350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100727.2">
        <property type="nucleotide sequence ID" value="XM_005100670.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863350"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045823443" evidence="5">
        <location>
            <begin position="26"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="31"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="169"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="7">
        <location>
            <begin position="293"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005100727.2"/>
        </source>
    </evidence>
    <sequence length="690" mass="74838" checksum="DED8A769A1127F3F" modified="2025-10-08" version="1">MARKFTPISLAAVAILLLRTPFCSGVTVTNIRIVNDQDPNSRQVGRLEIQVDNAGQWGGVCDDKFGQNEAIVACRMLGFTNGGQAILDGRYGFVGSFLMDDTECRGDEGNLTQCLASQQSDCTRSSDFMVGLQCNDNIGPGGGTPSPVVTTTQAASVISDNCQTTNPTVRLVGKQGVPGIGFVEIQNPNTRRWGFVCDDGWNEMAAKVVCAQLCFPTTYIAKPGIPAEHRVQPANPDVILDNTQCAGTEASLQDCPHAAWGVEDCLETDGELAGVQCVAANYEPPPPPVPDLQCANGLLVATFSRISDPDLEAKHITVFSDPACADVSKDTTTTAVSISIPVNKCGTILSGNATHVRYSNILKYDYTSQEGFITRVNTYRIILDCSYPRNDTVTQRVQPLTESVTQSAIGRFQFSMEVYRNDSFSTPEVTNPVQIPLGEYLNMAVLMTDYDDQLKLVVTDCLTTPAGDVLGNVKKVLFSNKCSQEPTLSFYPLSHDKYGFRFKPFKFVGFDLLYVHCDALVCLKSDLTQECDRTCNNEKPGTTGRRRRRRRSLALYRARLDSKAIVIYDPFAPGDDFGNTDDDDIKIVIGKDDKPMTQPPGTTAKPSWSPSILSTQSSSTPAPSSTAAWAPPPTRPLSSENLFEELTDTSKEASGEESGHKKMGTDGATSSQLCLSAFVIAVLSLCLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTX7</accession>
    <name>A0ABM0JTX7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ homolog subfamily C member 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101406.1">
        <property type="nucleotide sequence ID" value="XM_005101349.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862808"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04119">
        <property type="entry name" value="RJL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101406.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30349" checksum="2CC53FF3E1A3E690" modified="2025-10-08" version="1">MSHSAKVPKGKPALRVKIISMGNAEVGKSCIIKRYCEKRFVNKYLATIGIDYGVTKVTQKERDIKVNIFDMAGHHLFYEVRNEFYKDTQGAILVYDVSSRASFEALDYWMEELSNEVTNKSEADSIVVCVCANKTDLRRAVDESEGRLWADAHGFHFFEMSALSGEGVNEMFEALFQGVVQTCENGGRREPITTQLGYTKEQIEAIQKLKNARSDHERLGLMPGASKDEVNKAYRRLAVLLHPDKSVAPGSEEAFKLLVSARTALLKRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU05</accession>
    <name>A0ABM0JU05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855348</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101456.1">
        <property type="nucleotide sequence ID" value="XM_005101399.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855348"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101456.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38087" checksum="85DF12265A595FB7" modified="2025-10-08" version="1">MLKHQMTKQTYEPRTPGGPNTDIATLDLSYVCNTGVDNVNVTANTVRVEAVVRLLDTTTVSPGDTFTLHAAVNSNDQEISVYPLTLTVADVDLYTDVYADNVTVENGSAVTPNVTSSPPVSMNIAEKKTVNVLFQVPGCTSSKVWLDSAMPVNTSAIMTVEDVQISSSGRNLGDLTKYDSEFTDTKTSTLDTSQINKWEKNLGVVSNPCVTRHTDDYKSDDDIISADITIQMADHELAQNGEIFYASFGLHVARFIFILDLAVTVVRTGSEQLEFNMTSSRDDVNSTSDRVEIDTMLSLSDTATAEGRDTVLLLFLPPYVSHVSTVITSPHKTIVSESLEGNVLTVNVSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU94</accession>
    <name>A0ABM0JU94_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101854176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101618.1">
        <property type="nucleotide sequence ID" value="XM_005101561.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854176"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="859"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="859"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="473"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005101618.1"/>
        </source>
    </evidence>
    <sequence length="1054" mass="115288" checksum="02A578B67A646ACC" modified="2025-10-08" version="1">MEVGVEISQKIRSAIKAKLMELGCYVDDELPDYIMVMVANKKTRAQMSGDLSLFLGTNTDTFTEWLHGLLVKLQAINTESSNQQSTDKNEKSKSSKKKEKSKKSDSSRKDKDKKSKKSDSKNIDLDPSSKNSVLNTEKERSVKSVTDDGENAHSDTVHVSNSGSKEPAPSESSKVSEDVEDVRQLLVTETTSDALAEELETTETEVVAKESREVKVTNSTKVKSNVAALSLKSGRRLSRSKSHSPERPAVSARKRKTPISVVSSVSRPGNDDEEEYDPHNPSVGSVASVVKVTNRKSSVPPALQANRALLMKAMTEAERSIAVKRKVAVTRPMSRSDSPAETYSPKRRCSNQADREETPPPYIPSKKEVPSQLRGGSTQESVRSSLARNDARHLLNKEERRELISRSRRQELLQSIGIQQEEKKTVHSSSRPLERKNEKDVVAGKVVHQREVRDERKSGGIKNFQITTRLVSAPGSNVVRSRHSQTPPSRDKPAVSRTTVAPPARSSVTSRLGKVVSERRSSSAGSDSVDLRTKQLSSRTGKVSAEVKDGRNGGSRTGLSLLGKEVVRKQCEAAVMSVKAAQTAKVRARSPDSRVVCCDPEIIALKEEVTEEIGDLEGSVELMEGKFEESSDKAKDASSSVDDDAEDLAEMISNDFEPEILEDSQNDEFTLDLDDDDIIKVVGGIDEEGGEDLKGALKQEEFKKGTRFIVTLDGIDEREFDEQQDSFDKFKLPILGSSGPRMSAEVVGQRENVVLDALASQVGPGMHPVLLQARLPPQTLHPQHALQDFPQSTTAKITPPKIQPFSISLKDSDDEHENKMEAKSYSDLSESVSEGVSAVKRAKLSERCRFWPACAAGGACEYWHPTTHCKTFPNCKFGDKCLFIHPNCRFDSKCTRPDCPFTHTSKRSGLTSAGGAPPHVIAIPQSHVLFSPTLSSKAYAAGFGAVPTRLPSSSLGGGHQTVCRFYPNCHNVNCSFLHPKPCRFGLSCRTPTCPFYHPSVPTKDKLKWQASQTSTLPKAQDSAILLHSGSKVVDVSPAPVKLSEGHVSVSSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW25</accession>
    <name>A0ABM0JW25_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">GPI alpha-1,4-mannosyltransferase I, catalytic subunit</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101861057</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_005102863.1">
        <property type="nucleotide sequence ID" value="XM_005102806.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861057"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005102863.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="47606" checksum="0AB9BF8F72210C2F" modified="2025-10-08" version="1">MLTRCSFGLQRRKMLTIKQWCILAFVVRLAMIAYGQWQDANMAVKYTDVDYYVFTDAAEYVTKGESPYLRSTYRYPPILAWILTLNIWLSPVAGKIIFVAFDILVGSLIYKIVRKSGCQENMAKNCALAWLLNLLPATVSSRGNAESVMAFLVLQSLDYLINGRTVLAAIFYSLSVHFKIYPVTFALPIYLYLGKSHSSMKKDEDPKTPVPFSRKNLRAILLPSPECRLFIGVASLVLGALTGICFFLYGRVFLYETYFYHIVRGDIKHNFSPYFYLLYLLSDPSAGLPLCLRLLLFVPQVLLLFAISWRFQHDPPISWFLCTFCFVMANKVCTSQYFLWYLSLLPVIIPSLKINALRVALLVVLWFLAQGLWLLSAYYLEFMGHNTYIWIWAASLLFFAANGLIASNVIDSYQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JX80</accession>
    <name>A0ABM0JX80_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101854884</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005103689.1">
        <property type="nucleotide sequence ID" value="XM_005103632.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854884"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05605">
        <property type="entry name" value="STKc_GRK4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF28">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="10">
        <location>
            <begin position="60"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="187"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="450"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005103689.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="71398" checksum="8335A7A9F10DF954" modified="2025-10-08" version="1">MELENIVANTVYLKAREGGGGKRKGKSKKWKQILSFPHISQCADIKNKINHEFTFMFDHQPLGRHLFIEFCNTKEPYQRSIGFLNAVQEYEITPEEKRQTKAEEILEKYLQPDSESYVTHVNGNQVSEIKDIMGQNKSCKALFDDCAKLVREYLSKEPFQEFLASMYFKRFMQWKWLEAQPVTKNTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILQKINSRFVVSLAYAFETKDALCLVLTIMNGGDLKFHIHNMGNPGFPEERAVFYAAEITCGLNDLHKERIVYRDLKPENILLDDNGHVRISDLGLAVEIPEGESIRGRVGTVGYMAPEVVKNERYTYSPDWWGLGCIIYEMIEGKAPFRARKEKVKRDEVDRRVKEDQETYSSKFSEECRSICTALLQKSPSSRLGCGVEGGEEVKSHPFFRNLNFKRLEAGMVDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDASDDSFYSKFNTGSVSIPWQNEMIETECYKELNVFGPNGEPTPDLIEGLPPQPPQRGFFDKLFRRRRPCCFRKEVRVGSSLSDPHQLEEGVPQGSILSPLLFKIKIDSIVKTLQNSIDSLYIDDFLICCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXK3</accession>
    <name>A0ABM0JXK3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005103905.1">
        <property type="nucleotide sequence ID" value="XM_005103848.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847978"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="4">
        <location>
            <begin position="36"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005103905.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46907" checksum="FABEC1F1EF4DC48F" modified="2025-10-08" version="1">MDQGARSRQTGATGARPKLTTSVKHYDKHPSPIFIEPREIGTFSIDSEGKFHHDARQLRNYVPPRNLTECRFDLTSGIEDSMMERDETNSREEFKTFLHWIMENKNSFLMEKPAKTDGARLGGGDSRFHRSAPDFVCTRGLVSRLLRVPYQYANEVELSVIKFRGTYFLCEIDQVSAPIYPEKENMYKWGCRFKQYVTADKGKGIPDLSRPIKANERFYSVVRFQLGQHSLVCRGQVDCEDPSREEGNRYAQLRIIKLREDKKGKVNFLRYKLLRAWAQGVLEGVPVFVYGFYSEENNVKAMVKSVRSYEVKDMPQMAHHPDVAGPWKPHVCWNFLEAFLDFVKANITEDSENWVYECRRKPREDIAFERKRNSEELNYLPDWFTNWGAWEDTVRAQSPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY84</accession>
    <name>A0ABM0JY84_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multidrug resistance-associated protein 7 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101854886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005104370.1">
        <property type="nucleotide sequence ID" value="XM_005104313.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854886"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18598">
        <property type="entry name" value="ABC_6TM_MRP7_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18605">
        <property type="entry name" value="ABC_6TM_MRP7_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF330">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1013"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1085"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1165"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1274"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1301"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="398"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="745"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1026"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1365"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="717"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="964"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005104370.1"/>
        </source>
    </evidence>
    <sequence length="1601" mass="178652" checksum="14C9E96C4F86BF77" modified="2025-10-08" version="1">MEELSSQRSRGVWNWSTLCDHGENLQAWEGSDFGHCFEQLAILSPTHAFLALISSYHFGRRRSSLRGNSLYVSWTSFLIVRFVCTVALMLSPVCQIIFSISLEHMLPSIADGVFAGLAFLSWTLHALYVWNVRYLHSNSLRGPLSAVISVLLVAVSSAVHVHTVVTRRMAHSPHQLATEEYTAYLNAAFCLIYFFTLIPNKSRIYHSDIFCLNGSEEASEPLTWDRIRSYSSTVPQRENVIVAEARVGCISWLTFQWVQPLMSRGAVKKINSVDDLYKLPRRLNTNLINQKFEKIMIKAFKSEDQRKTRALDASGSFENSFGNSAVVSDQHQAVNDRGQSLNDPSQYQVRYEGMRTQDENITSSPYETGKHSLRQISLFKVLNSAFGLEYYCLGMLRLLGDCLSFAGPLLLNYLVTFIEDRSEPMFHGYLLVGGLFLSTLLGTVCYTQFDYNVQVVAYKIRCAVVTTIYRKSLTISGVAQSRFTSGEIVNFMSTDCDRILNFCPSFHAFWSLPFKVAVSLYLLYQQVGLAFLAGLTFAVLLVPVNRWLAKKIGKLSREMMQHKDGRVKLMSEILYGIRVVKLHSWESHFADRIASVRQQELKCLRGRKYLDALCVYFWGTTPVLISILTFGTYVLMGHTLTAAKVFTSLSLFVMLISPLNAFPWVLNGLVEAWVSLQRVQKFVCLTDMDPGAYYSPPAQSSDSGAGPVIRISNASFSWQPSSSDTEEKAAANTVATTEGGNDEQDNLSDLSSDAASSMVQDLLNITVDVHRGQLVGVIGRVGAGKSSFLASVLGELRRLEGEIAIDDLDAGFAFVSQEPWLQQAAIRDNILFGRPFESQRYNKTLEACALTEDLKMMPSGDLTEVGENGVTLSGGQRARVALARAVYQDKSVYLLDDPLSAVDAHVAQHLYTHCIAGLLGSKTRVLCTHQLKFLARADWVIVLEDGNIAKSGVPSDVLPHVQMLESNRPGQRHKDKEDEEEKAAAKREEAKEENLVKEEGREKGVVKAAVYKSYWLAVGTCLSPSVLLALFFMQASRNLTDWWLAFWVTHSQDSSPLNSSVPAVIWPVRNIPAQNLSSGSDNLNFYLGIYGGLAACNSIFTLMRAFMFAYGGVKAATVIHQRLLKAILKAPMSFFDMTPVGRILNRFSSDLYAVDDGLPFILNIFLAQTYGILGTLVITCYGLPWFTISLVPMAVIYYKIQHYYRHTSRELKRLSSVSLSPIYSHFSETIIGLTTIRAMRHSTRFCQENIVRLDMNQRAQYATQLSARWLDFRLRMLGVAMVTCISFVAVIQHQLSSVNSGLVGLAISYALAVTNLLGGVVMFFTETEKEFVSVERCQQYIVETPVEKWNGTLFPPSVWPSEGVVEFEDVCLRYNNSQARVLNGVSFKTEPGEKVGIVGRTGAGKSSLFLSLFRLAELSQGRIIVDDIVISMLDLNDIRSKFAIIPQDPFLFSGTIRLNLDPTSVHSDSDLWAVLDRCHLSSCVDRMGGLEAKLTQRGREFSVGQRQLLCLARALLSRAKVLCIDEATASVDQETDSLIQSTIRHEFRNSTVLTIAHRVNTVLDSQRVLVMKDGQVAEFAPPDDLLKDSSSLFYQFVYGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1C1</accession>
    <name>A0ABM0K1C1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRELI domain-containing protein 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106436.1">
        <property type="nucleotide sequence ID" value="XM_005106379.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854662"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106436.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23425" checksum="244142628B134EB0" modified="2025-10-08" version="1">MVKFLFTCSVFKYSWEQVATGLWQRYPNPNSKHVLTEDVISRHTDGNKLISRRVLTKTNKIPKWGERFVGGDSHVLIIEESVVDPDQKTLTTYTRNIGLQKIMSVDEKCVYRTSPDNSSWTVCERSAFISSSLPFGFSKPIEVFGVKRFRANAEKAAQGFDYVLHSLFKPDSVKDHPLVASSKIKDTARRAAEMAKSKTAMLQRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2C5</accession>
    <name>A0ABM0K2C5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846523</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107095.1">
        <property type="nucleotide sequence ID" value="XM_005107038.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846523"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107095.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23804" checksum="7B3CC42197BCA559" modified="2025-10-08" version="1">MPEAPPVFDYGKVRPDTRHLKWVLPPSTRGMQATLHKDVPRILQPNVCHDADEYLAAARRILHRQRMTARMLPRFNRAKSANYATLLKEIHEAEDSQMDLVHLPKFTRSVEAYQVPVFPGRRYSPNDVMRIVDRLSTYDPEKSLQRSSPLTGPAESKGVAPVTLTEPNRTSLCKVKKCTSQEVQDIVDRLSSFDPTKWPPGSRSEARSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2P8</accession>
    <name>A0ABM0K2P8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein Rab-3D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107372.2">
        <property type="nucleotide sequence ID" value="XM_005107315.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851670"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005107372.2"/>
        </source>
    </evidence>
    <sequence length="206" mass="23058" checksum="09550E9B4A265286" modified="2025-10-08" version="1">MTKKTSVISAPSKWTDSFGLSRKLSKGIQKYKVRLITLGDPAVGKSSFLDALVKGGGTPGTHAQRGVNGHLSQVNKVVRHGDHEVELDIRDTAGQERYRSLTASYYRNAHGCLLFFNVFHKQSFDNLEQWVDDINTHSKQDNIPVILVGLLHRVNTTKPTPWEMTREPYGGVWSNRRSNAFGRADDSSSRGGDIADDNHQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2Q3</accession>
    <name>A0ABM0K2Q3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Replication protein A 70 kDa DNA-binding subunit isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Replication protein A 70 kDa DNA-binding subunit isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101853118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107378.1">
        <property type="nucleotide sequence ID" value="XM_005107321.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005107379.1">
        <property type="nucleotide sequence ID" value="XM_005107322.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853118"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A OB" evidence="3">
        <location>
            <begin position="163"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005107378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107379.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46762" checksum="D5F264B438962A37" modified="2025-10-08" version="1">MSTEGYSTPMKKRMEQSQVEGSSSTPGLKRSSQDSSKRGVHSIASLDLNKKGWKIRARVIHRSDMQHYSNDKGPGCFFKVIFLDDSGEICCTGFNEWAHAYFDKFTVGEVYYISNCLLQNAKQKYDTVKNKNQMTLGRDSRIEICPDYSRSTVPDMKFNFVKLSDLEKYENDSLVDVIGVVVGCDDVVPVPSKLGSMKRDLRIIDGSKMRVTLTLWGETAKTFDGENSPVVAVKRAKVTYFNEKTLSVLVESPLRMNPNLKEADDLRIWFDDECKDLDSDLFETGGERKFPEQIYSLGSTDDSDNIQSQYAEDFRSSPEPRPGSSSKRPRLHSPRVATEEDQFDSYGKTIAHKLRDLPREQSLIAENFCNVALFEASFGNLTRETTLSLNSPVADHGCRGTPGARGTAGARRRILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3V4</accession>
    <name>A0ABM0K3V4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Suppressor of cytokine signaling 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC101854668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108140.1">
        <property type="nucleotide sequence ID" value="XM_005108083.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108141.1">
        <property type="nucleotide sequence ID" value="XM_005108084.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854668"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF16">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="152"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="254"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005108140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108141.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35433" checksum="D1393A5669F3942D" modified="2025-10-08" version="1">MLQPPHRERCDSADMEEVIFRICRDYDKDRLQRFLSETRQNLPLVLASDSRLCKASSHSTPPGTRSVSSCTSREVELRRQVSVAEPGASGNNNQHEEHDNMVRNNDRDNRAGHDEVTKDSGVSCERLSSDVDSELDFDTLKKNQEELVAGCFYFPSLDQATAMELLRKAEVGSFLVRDSSHPDYIYTVSVKSEQGATSVRISYIDGLFGFDGDEEQPKVHTCFGSLMTLLDFHALNLRKYGKRLTMRAKTCRKAVEIPFIKPFRRTVPSLAHLARVKINSSLDTGEFYELSVASLPLSSKHKQFLRDYPYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4F4</accession>
    <name>A0ABM0K4F4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Retinol dehydrogenase 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC101861767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108509.1">
        <property type="nucleotide sequence ID" value="XM_005108452.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108510.1">
        <property type="nucleotide sequence ID" value="XM_005108453.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861767"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF50">
        <property type="entry name" value="GH26015P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005108509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005108510.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35792" checksum="674AC8635720BC08" modified="2025-10-08" version="1">MWLMIAAIVTGIVGYLFINRFLRSLDVGDYGNKYVFITGCDTGFGHRLSIRLNKMGFHVISGCLTQKGADTLTQLCPDRLSALLLNVADSDSIQKAYKHVQDLLPAGKGLWAVVNNAGISGNTSRIEMCTKQDFVDAIDINLFGPIEVSRTFLPLLRQTRGRVVCITSILGRYPSGPAPYCTSKCGLEAFCDVLRREVYLQGIKVSILEPGVFRTNIMDFESLKSKCESSFDQASDEVKTAYGPDYVKNYVTLVSETMKGASTDIDQVVDAYVHAITSKFPRTRYVVGNDAKFIYIPLSLVPDWCGDWIVRSLINYTISKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4L4</accession>
    <name>A0ABM0K4L4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108638.1">
        <property type="nucleotide sequence ID" value="XM_005108581.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851223"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005108638.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25134" checksum="E1F88FA3C43BD5ED" modified="2025-10-08" version="1">MGRRPARCYRYCKNKPYPKSRFCRGVPDPKIRIFDLGRKRARVDEFPLCIHMISDEYEQLSSEALEAGRICANKYLVKNCGKDAFHLRVRLHPFHVNRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQPIMSVRAREQHEPQVVEALRRAKFKYPGRQKIVISKKWGFTKWPREDYEKMRADGILVPDGVNCQYKPNHGPLDAWRSRQVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K545</accession>
    <name>A0ABM0K545_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101850912</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108977.2">
        <property type="nucleotide sequence ID" value="XM_005108920.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850912"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045194816" evidence="2">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108977.2"/>
        </source>
    </evidence>
    <sequence length="265" mass="27635" checksum="DF967AC0BF52A74A" modified="2025-10-08" version="1">MPRICILLMLSSIFVVLIRVSHSEEIVTQQSQPRSLSPELVETVHTKLPVNGETSTVHASESLSQAQGEINFNLGDSTAPSLPSTAEQLTPTPDGERVFVVAAGAGGAAAVVVIPETGDKESGAADGDNGGLADQTSSGEPEVSESLSTVPATQADQAGQLDLHSLSVTEPVQEEQLLPTAPQITVLQDSGPTQSLELPQGDDLPAAQHTHHIAQDGGTQASFSQAERVTLEPVQATDSLHSLRPEAWTEVSQLPEGLGGRVIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5B3</accession>
    <name>A0ABM0K5B3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101860606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005109099.1">
        <property type="nucleotide sequence ID" value="XM_005109042.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860606"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="108"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="309"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="686"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="745"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005109099.1"/>
        </source>
    </evidence>
    <sequence length="857" mass="95847" checksum="11425D82DD5B3D07" modified="2025-10-08" version="1">MGRRKWKAKKLEKKLQKESGSGLQSDQLSHNKRKDSTVPEQQSQMKLDKQDMESEDSDVEMASAKKLATLKTKKKSGGFQSLGLSHGVLKGVLRRGYKVPTPIQRKTIPLILEGKDVVAMARTGSGKTAAFLIPLFERLKVRSSTGARAIVMSPTRELALQTLKFAKELGKFTGLKAAVILGGDKMDDQFAALHENPDIIIATPGRLLHVLVEMEMKLKLVEYIVFDEADRLFEMGFQDQLQEMIHRLPESRQTVLFSATLPKLLVEFARAGLTEPTLVRLDVDSKLSENLQLSYLSCREADKCALLFYLLKHVIKPKEQTVIFAATKHHVEFLNLLLTLSGLSVTYIYSSLDQAARKINAAKFSLGKVKILLVTDLAARGIDVPLLDNVINFNFPAKPKLFVHRVGRVARAGRTGIAYSLVSPDEMGHLVDLHMFLGRPLKLVPLGQKVEDVDGCLGEVPQSLIDDEDVEVQQTIKDSVDLSGLVKVCTNAYRKYAKSRPAPAAESVRRVKKMVEEGVMLGVHPMFDSADVDEKGVRLEMLNALKSYKPKTTIFEINSTSKKSGLAVMKAKREQHERIIVSNEERRAEKDQEQTSLSSFMPESTTFTWTSKPAEQGDIDAVFDEVVSSRAKNSRKSKSAKSAAIPTEIKDKENFIEYRPSDYASERGLSIANNFEREAAGAVLDFTNEDDEGNNDKKKRKWDRKRKKFVTENDEGGKKKKIKTESGNWISASYKSNAYVEWRNRSKRGDYDDDDDGDGGGKMKKGGGGQRGAGSDGKFTVVGMRKRKWHTRGMENETSSKQNKMKFKKGKGELHSADQILKKRRQKAKVQNFQKFRQNTRAKRKGGGKDTGKGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5E5</accession>
    <name>A0ABM0K5E5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Zinc finger protein 525</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC101853585</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109155.1">
        <property type="nucleotide sequence ID" value="XM_005109098.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005109156.1">
        <property type="nucleotide sequence ID" value="XM_005109099.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853585"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005109155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005109156.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40280" checksum="BEF18F489DB5EF9A" modified="2025-10-08" version="1">MMVGFVSNSDSSSHLYPAAYADPGFAQFNSQHTCSFSSSYNQMKVDLSLPQEKQLVPRFQLSGDDQKLLNDKPHKCEFCGQGYKHRQDLRRHIRNNCNKCDLCGAKFKSICSLRKHILAHTGEKPYKCGVCGAGFGHKSHLNRHTLIHTREKSYKCNVCATEFTTFSDFKRHNLLHTGEKPYTCDVCNAKFRQFSGLKQHALIHTGEKPFKCDVCESRFRLKNHLKQHTLIHTGEKNYECHVCDSKFSTYSDLKRHTVLHTGEKPYRCDVCYARFRQASTLKQHTLIHTGEKPYKCNVCEAKFKQRIHLKQHSLIHTGERPFKCDMCDASFVRKSHLKQHALIHTESAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5W4</accession>
    <name>A0ABM0K5W4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101863619 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109457.1">
        <property type="nucleotide sequence ID" value="XM_005109400.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863619"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005109457.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="61424" checksum="9355780D6979E5BE" modified="2025-10-08" version="1">MNQQESSMGKKNMASGGDPYNDEEISRARTLLLDQMEIGRMQYLKRRLVVGETFPNLWEGEEGMMEHIMCPFPMPDVEMENDPVESSEGSGCGSERKAHVHSGGDARVQVSNSQSSGGSVEGLSSTRDSLCSSDQQESGTGSSSSTAPAQSVSKSRTGTVTSLAENKQISSELLSATDHFLASISSASNNSGIDKDSKVSSEGASSASEEVTISSCTSDSGAVSRPALESGCDAVMQSTPGDEVESPQSPNDLSVEEEAVSIEELLFWQKVSSLYFELLEIKESVEKSDIEAIKTEGALLKAFRILKKTRFKLNVLEKQFKCDQQERMQHGYNIKMPKLLKVKEQDANQHCWNIYDITRCFNRIRSLLKKKRSAVTKARKQLKLVSGEGSSGQSSSPCSESYVSGISESLSDSGQNIGGVPSHKHEQEMSRQESKYWKSLEEILLQLRRFSSKFGKLQFRKGKKYVLKGSRLAVVGKLKRQITVLEGNLKAKQQEGSQMGYRISRKRPKHQSKREKRQFVADLKQVNEYFVIVNERFQAVMKQIENVPEINVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K659</accession>
    <name>A0ABM0K659_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101848079</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101848079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109648.1">
        <property type="nucleotide sequence ID" value="XM_005109591.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848079"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005109648.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11178" checksum="EEB81D2A80214F3B" modified="2025-10-08" version="1">MDERPLIEGAHLSDSDSSFESLPAVRRGGGEMGMTQRGGEMGMKHRGAENGVTQIVGDAESNLTENGGLHKQVTDSEQKVTYTIQEAIDHMGFGRYQVMIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K684</accession>
    <name>A0ABM0K684_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101856469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109685.1">
        <property type="nucleotide sequence ID" value="XM_005109628.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856469"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005109685.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19126" checksum="6313AD05CD057F85" modified="2025-10-08" version="1">MAAVLKYMRTKEFRDWICSTHFWGPVANWGLPLAALGDLKKDPEIISGKMTMALSIYSLLFMRFAWKVIPRNLLLMSCHITNEVAQLTQGARFINYHYVMSEEDRKKYHVKLVDEELHKHPEEYPEVKAIAHAPPYSEQEIKAEVEDFDKHYKVKKDTSIKTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6L4</accession>
    <name>A0ABM0K6L4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin, clone 302</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109965.1">
        <property type="nucleotide sequence ID" value="XM_005109908.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862536"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109965.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="42427" checksum="7F904717028BF77E" modified="2025-10-08" version="1">MEHQVSSSELSPEASAGDPIKVVLDNGSDTTKAGLAGDSTPKVICRTVVGRPRRKGLKVFKNQGNFVGKEALSKRGILALSSPIDQGHIVNWDDMETIWHHIFDKELSISPDEHPLLLTESPLNPKADGEKMAQIMFETFNIPALYVANSAVLSLFADGRTTGTVLKSGRSVTHAVPIVDGSVITDAITRTEVAGRDVTDYLMSLLNNRGYSFTTEADRLVADDIKEKLCYVALDLNQELHSAAEFSTLHKSYTLSDGSVMNLSDERCRCIELMFDPSLLGYVTEGLSQMVHNAISRCKEETWKSLYNNIVLAGGATLYKGLHDRLRAEIVTLAPAEMKVKVIAPEDRKYSAWLGGSILANLPSFKDKWVSKQEYDEVGPSIVNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7K3</accession>
    <name>A0ABM0K7K3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mastermind-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101864182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:63117"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="RefSeq" id="XP_005110633.1">
        <property type="nucleotide sequence ID" value="XM_005110576.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864182"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF4">
        <property type="entry name" value="PEROXYNITRITE ISOMERASE THAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM3 N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="THAP4-like heme-binding" evidence="3">
        <location>
            <begin position="619"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00036993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005110633.1"/>
        </source>
    </evidence>
    <sequence length="772" mass="87998" checksum="480490F6BD4E68C9" modified="2025-10-08" version="1">MAVEVGAEFDTYDDLTSAVQAYEAENFVNLIIRDTRKVEAAAKRNQRKKYNPAIKYSDISYCCTYGGKKYVSHSTGKRSHKTIKQACPFSLKVRATVDGQRLFVREMCPSHNHELSEVEFRLHPKQRKLDQGSQEEIATLLSLEPDKKLLREKLMQVTGKVILMKDIHNIKTRLVNPKLKPMSGLANDNDDDSTENNDLDIDSSGDSVGELGPLNIIGISEGQEEQPIEIHIPISNVSSLSPSHLGHPQHAIIMQQAKPQGQAVQPPPQLQIAPHLKVQAVPVTGTSHGQPQHQQHLHQQLHQQQQQQHLQHQQQQQQQPQHHHQQQHPQQQHQQQQQQHQYMVSQASYQPPTVYAVTGQQFQPSPAFCLHTQHYQQPTTLPAAVAVTSPSMHHTLPSVNAHHDMRTSQPPFPPWPGVDEVTTRNLARDPNDPHDLSSYQQAVTTPAFAALPQTTDLQRHIHLQQQQQQQQQQQHQNIPLTDSESAAVTNIVTTTNIEQHHQTPQQQQQQQQHQQQQQQQKNPQLRPPPPPQPMHQHAAQLKRRRKQRPVPNSCVTRKRKTAIQSDKDSIMKKYFQQATVKLFFNERLRSPGSKFLRPLKSSVISANMSGEDLKFHDLLKPLAWLFGTWKAETGKGQYPTISEFTYTEEAEFQPIPKKPIVEYKFYSYKTDGSMPLHRETGFIRVKPQTNHIAFVSAHNLGVVEIQEGDVQGQALTVETADLGRTSFNKPPEVKKTKRTLKRLGDELEHVMFMETENTSMTEHLRVLFKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7X2</accession>
    <name>A0ABM0K7X2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/arginine repetitive matrix protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110911.3">
        <property type="nucleotide sequence ID" value="XM_005110854.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852967"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110911.3"/>
        </source>
    </evidence>
    <sequence length="449" mass="50343" checksum="F243A2C079377851" modified="2025-10-08" version="1">MMSNAQPKHRRKGTPRWSKKMKKKAVLRGVVDKLWERQERLTEERKENQVEWTEGNGEPVPGTKWQRENNLEEIKMYAERADYSLECDQQAEKQDANKKNQTTNPAKHRRKGEKPSRVTTPNVAALYGPGVPPPDKRQKQGPPTHQSSADPIDLEIRPPPSSEVPPTPKLAVSTLPPPSSEVPPTPKLAKAISSSPGSHAPTTATTDWVHPEENLSDVISRREVSSTPPPLDKKAQPKHRRKDFPRVSEKMRKEAVLRKVVDKLRENVERLTEERKKPRVGWTKRQRKNNLKQIKKYAENADYSLECDQQAEKQDAKKKNRTTNPAKRRRKGEKPSRVRTPNVAALDGPGVPPPDKRQKQGPPTHQSSADPIDREIQPPPSSEVPPTPKLAVSTLPPPSSEVPPTPKLAVSTLAPPSSEVPPTPQLAKAISSSHEVSNLHVQNFEDFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K831</accession>
    <name>A0ABM0K831_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger BED domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101861550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005111024.1">
        <property type="nucleotide sequence ID" value="XM_005110967.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861550"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1070">
        <property type="entry name" value="Zinc finger, BED domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="11">
        <location>
            <begin position="626"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005111024.1"/>
        </source>
    </evidence>
    <sequence length="708" mass="80782" checksum="B54AA47F3F73A1C3" modified="2025-10-08" version="1">MSSTPKRFYKQQNAPRFRSGVWHFMRKDDHKNATCLICNSKFKFHGSTTSLRSHLRAKHPEHDFSGEYDQEEAQAASRLVNLLQPVKAPEPSPSPSEVKPESNRVKSGVWKLMTKDSPYIATCIVCNAKFKFHGSTSSLWAHLKAKHPVELDNSATEDPNESQLLQFSAAQNHPTESSVSGSASVTVSVKKSETSEKISFHREPTTKKKQLERVLVEMIVRDLQPLSIVEEGGFQKLIHTLDPKYTLPSPKQLATTILPNLQKEEIRKLKAELGDIANVTVTTEIWTSVVTDSFLTVSVHYLNSQWQRKYAVLETCKLVDDLTPANIAEELSRVFTAWDLHPKVTCVVTDNSENMAAAMRMLRLPHVTCYAHTMDGIVRDSLRNVQEVTRLAKKVRDIVSFFHHSEMDSEKLMHLQREQERQPQKLKRDVPSQWVSTFYMLERFIHLYGFIAGALYQVGRAELLLSDDELEVVKHCVKVLEPFEVAVKEMTSEKHMPMCKVIPMTKAISQFVSRNTQNSGGDISGLATELELQMSRHFDNMEDNFLYGASTLLDPRFKKLPFSTSEAVGNTEQQLGEEILIQTEPAAVLKPETEAMDDSKSLWSSFDQQVEFTLSALSNPQESTVEFNRYYEEMLLQRQENPFRWWEKMSKFLTRLSPIAMKYLAIPAASIPAERLFLKNQEVISLRRSILKHSVVDTVLFLNNRFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K930</accession>
    <name>A0ABM0K930_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101851690</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101851690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111802.2">
        <property type="nucleotide sequence ID" value="XM_005111745.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851690"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005111802.2"/>
        </source>
    </evidence>
    <sequence length="586" mass="65420" checksum="FB5F0649585DBC6A" modified="2025-10-08" version="1">MCRYGSISLVENNFTYQIVHDLAHELGHSLGCNHDGEKNTCSDKDGFIMSERPDINSTNRWYFSPCSANSIREDLLILENDGANCLKATAIQKKSAPQLGSLYNADRQCKLMFKDDAYFCRDFYSNSSDYHKMCSSFWCSETRNSSQCVSHIASDGFLCGDSMVCSKGQCVKTEGAPEALDFCPQGDQPDLVHEQMTCEDLVRLEPWKCYDEFYRRKCCVSCHGIKQEVKGCEYGDKEDWCKGEEISYPYDCYLNNQTCCASCEKLKNPAKKGCEYGDHTAACTSSLDIPMGCYGNEELCCGTCALHKNASNTGCEYGDKSTWCSEKLVAPSGCYLNEELCCGTCSGAKRLDNAECPYGDRYPKWCPKATPHRCYNDTVKEWCCDSCSQSHNASRVGCEYGDKFKNCEELIYPYACYHPTNEKACCQFCSTYLNEDEDAKDCKYGDKQAWCWKLTLTYDDAEWCPLDKENDHCCGSCRLNQTAVPVFGYRLREEGLEQVTRLGNMFKAEVRAAVEKQKQEEKAKKAREEADKAKADKAKAEGQADGSAASGDGDTSSADNAGRTTSRRPARAATDDSRGQTDATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA47</accession>
    <name>A0ABM0KA47_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable serine/threonine-protein kinase CCRP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112601.2">
        <property type="nucleotide sequence ID" value="XM_005112544.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862767"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112601.2"/>
        </source>
    </evidence>
    <sequence length="258" mass="28556" checksum="EA6123DA1CC6A798" modified="2025-10-08" version="1">MGYHPTDLSHGLLDVTYSEAESYTSQLTDVMCYLHGQRIIHGDLKLGNVLLDRAGRVKLCDFGHSQVIPEDTDKPDGWGGTDGYKPPELYHSQVHNAFKMDNYSLGILLWALFFGTAPRNNIDYLKEVDNCSFLKPQHKHCLQRLLSLSPTHRAYIWEIARILKDEDTSERYVSKGSVCSLSSESSSDSAQANQSSPDSGSSVTERPESAASPNQFLATPPPHPHATSCYLLPQTAYPDSGDVPTSLAPTWPPLHQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBA0</accession>
    <name>A0ABM0KBA0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101845983</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101845983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nephronectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005113452.2">
        <property type="nucleotide sequence ID" value="XM_005113395.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845983"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046921891" evidence="4">
        <location>
            <begin position="23"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="6">
        <location>
            <begin position="355"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="540"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005113452.2"/>
        </source>
    </evidence>
    <sequence length="788" mass="85711" checksum="C5B7008885EF165B" modified="2025-10-08" version="1">MSAVRVLLAFLLVLGLTTPSRCEEQIWRSFSRYRRQTSGQGLGPTEEGTSISRTCAYNTGAGGASLTWEVQLAAVKRAVATCVTNQVPYNCTVSSGFSSLFTVTTDQTQATLTWNADRRFLSLSCSQFSVIASWTLVTYSKPTDLTCRSPEITNNDNTVSVTCVSSDIFPQDPRCVLYRQTDGGSRVQTSVPPSYGTDTTGSVSGPSCTFTIQAPELGAGTHSLSVNMYPQFDGSGENYGVNRAVSPDVTFYYPVPEIVNCPSGAKVSGNYIMSGSTATCECRQKTEGFPAGTVVLSQGGSTLGSGTVVSGNINNPGNNNNDQTLTCRSVSSLGQAGPSVSKTVTFASYTNTASLDCDFQTDTCDWTQVKDDQADWRRRRGETNSNGTGPFYDHTYGNFTGVYIYFEGGDVSRANDTASLQSPLLPAQTGAVFSFFYHMKGYQMDTLRVRLVTYDFFGRETSEKILFQKSGKEQTAWAEARIDVDETESFRLFVEALLLHDFGDYTDMAVDDFRFFRTCKSNPCGTDQTCNDRQFGFACAYNCTTAPCLNGGMCGAEGESYTCRCAPGYTGPNCETDIDDCRLLPCQNNAVCIDLVNSYFCACADGFTGTTCEIQLETPECHGLVVDLHATPKTLTPPITAELNITCSLRLATSNEKRVCEDVISFDFGGVASVALTRKGSRDVIEETVSVMSFFENATAKTDHGMLEVEGWLRHVMTSQSPALASLDNRWFYPTDDQAGDYSCTVVAIGSLGRPLTFQVRQKIKVSIPAKQEVRRYVANLHNSSCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW38</accession>
    <name>A0ABM0ZW38_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable serine carboxypeptidase CPVL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935747.1">
        <property type="nucleotide sequence ID" value="XM_013080293.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846567"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047157739" evidence="7">
        <location>
            <begin position="21"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012935747.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50562" checksum="9E2DFF7CA157F091" modified="2025-10-08" version="1">MEVLLGSGLLLLCTGASVWACGDPLMLTPILEAGDVDKAQNLSRVVMPALYNGTSHAGFLTANKTLGNHLFFWFFPSMEQEDAPLLVWLNGGPGISSMLGLFWENGPVEVDMDMAREGFIQSEPRQFSWVGPFSMLYIDNPVQVGFSYTESGDMGLRLNQEGYSEDLYSVMLQFYSLFPDYHNRELYIGGQSYAGKYVPALAHKIHVGNRDGNTHLPLAGIYLGGPYFAPEEENLAFYDFAFAMGFVSHATVVERKRDIAKVYEKVREGNNPEKESLATMMSLFWVHVGLQTKDNFVTQQRAGYGLLSDLMKIQEVRKALHVGNQTYNAQSYTVYEKFGGDLVVSTIPQMADLLDHYKVLIFTGDYDVIINSPMVEAGLQATPWSLREEYLNATRSIWMSSSLDLCGYFSLTGQFCRVVVHGAGHQVPHDQPQRAFQMITDFVRHGCIQPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYR7</accession>
    <name>A0ABM0ZYR7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012937307.1">
        <property type="nucleotide sequence ID" value="XM_013081853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853311"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="86"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012937307.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="61958" checksum="05BE28CEC7146B31" modified="2025-10-08" version="1">MTTWKMDVEQLVTDLSACGRFQVLLTAITYLVKTAGSWAMMMMAFGSFHPGWTCTDLETMDGNKSQNLSSFLWSRPLQSHYDLSGVSLNASLNGNVSSFSLTPGPGARGDLTLGRANFTQDTCTELSGCRNVTINSDSQTVATEWSLVCDRAWILSFIISIQMSGVAIGSYFCGYFGDRYGRKLSMYSSLALGVISNTVVYFTTSWEMFTVVRFFIGLSVGGNLALSQIYPMEFVMPKWRPVVSGFPSWHVGTLLFGVCVMLLRDWRLVQLATAALSLLALLTAVWVPDSVRWLLVHGRVRKAERVVTQICRFNGMEVPDTQVSLINITEGSNHRQEKSAKFSFFQLFHASLRKRTLLVTLTFFLTSAMFYTLSFGVQSLYGDFYLNFILYSLFPIPLSFLVPVLGNKLGRQRALLIFFILVFLGFVSIVVIFFTTSGSLRGITITCLALFTANWLQQTLSLLNTFAVELFPTVVRNLAFGFAMTGARLGSVIAPYVIPRDFDSMYVSYLIMSAMALVCCVAVWALPETKGTAMEDIIQDKNEKTSKAEKQVNSNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ03</accession>
    <name>A0ABM0ZZ03_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18">Stromal interaction molecule 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC101848429</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012937447.1">
        <property type="nucleotide sequence ID" value="XM_013081993.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937448.1">
        <property type="nucleotide sequence ID" value="XM_013081994.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848429"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11722">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057835">
        <property type="entry name" value="EF-hand_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032393">
        <property type="entry name" value="SOAR_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037608">
        <property type="entry name" value="STIM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136:SF5">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25578">
        <property type="entry name" value="EF-hand_STIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16533">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="15">
        <location>
            <begin position="206"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="313"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012937447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012937448.1"/>
        </source>
    </evidence>
    <sequence length="586" mass="65935" checksum="7FBA94B565C54EAC" modified="2025-10-08" version="1">MCVHFLELEIQHKFCSTAPGKLASFVHITSFSVMKRLCYVLKPWTRIGFSHWLSFAIALCLICGSFGANDEEILKVDVVAGSNPSANPNLIARQDSVSNDQHRHGGKSSPVGSGSSNKADIIDCHDKAPDECERDRLGLEAIRVLHLMLDDDHNGNVDQSESDEFLRDELQYTDGFERQALFHNNDKLISVDDLWTAWKYSKVYNWTVDDVVEWLAQDVDLPMYVQVFHSHNIDGSYLPRLVNSTSSLLATLGIRNPVHKQKLSLKAMDTVLFGAPKRVHSYAKDLLLISLIIVAFGGCWFLCLHNRYSQTQVKKMMKDLEALQKAEDALKKLSKELAEAERNQKSVSQEKQEELRVLRQNSLRLQVPPARVANSEDRSPSSLSREGSVVRRKDGERRLQQAEEELATLREALSEAESKLELQQHLESQWSAPVELQAWLQLTHELEQSHYHAKRQAAERQLLMARDGCDKIKKRNKAFLGSLRMAHSNSLDDIDQSILDARAALEEVKHDLQERLHRWNTMELLCGFSIISNPGLAALKQALGRDPSGSTGSSGRVPSSLLAPVSIDEADEDLPPAGRFAFLFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ54</accession>
    <name>A0ABM0ZZ54_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium-dependent phosphate transport protein 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101855017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937515.1">
        <property type="nucleotide sequence ID" value="XM_013082061.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855017"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01013">
        <property type="entry name" value="2a58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037997">
        <property type="entry name" value="Na_Pi_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="694"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="796"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012937515.1"/>
        </source>
    </evidence>
    <sequence length="820" mass="89428" checksum="19FC627AC5C5D21A" modified="2025-10-08" version="1">MDSEIPVSTGDLIVNNVDLDEGVVIDLEEARGLSTGTPLLKNGSLNGMLTAEGLHKSSKDSGFSSRMSEAGADADERARHLLLGEHKGALTKRLNRISECQYEEPCACSPGGVAKAAAKILGVLCLLYMFICTLDLLSNAFRLLGGKTAGSVFSDSDLLRNPITGLMIGVLATVILQSSSTSSSIVITMVSSNIIEIQPAIPIIMGANIGTTVTNTLVSLAHSMDRREFRRAFSGAVVHDVFNWLTVLLLLPLEYCTGYLYHFTQIIVDSFNMEDMKAKKQDLLKKLTKPLTSRIIKVDKKVITGVAEGKPEYLNKTLLKVYCSYEKVPSFVMVNESSTDNVTGETSWEMVNKSVEIKVPLEKCDSLFSQLGWSDSVSGIVLFLSSILLLSICLYLMVKILHSLLGGQIAKAARKTINADFPRPFHWLTGYVAIIVGAGLTILVQSSSVFTSALTPLVGVGCLKLERMFPLTLGSNIGTTFTGILAALASSSSTMKVALQLAFCHLFFNITGILIFYPVPKMRKIVLGCAKYLGRTTAHYRWFAIAYLICMFILFPGFFFAISFAGKIVFIVALSLISLIAVFVVVVNIMQKSKRLEKFLPLTLRTWEFLPEFMRSLAPMDRCLQKAIEPLSKCCCQCCINRCSCLSANQNEDSGYIDSDTEDSNGCSVQSSYLPSATSSKFCLADGKIPESKKIYRPKESASRKSSLSKKSQSPLLGRRVQVEDLNTSVVSCNDESVSHSSNTSSKSNKDIGASTLVQVEDETVRKSPVSERSSFKETAPSKDSELASSSSRLSHSQEGDTEVDRASSNDIDNMRESII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ86</accession>
    <name>A0ABM0ZZ86_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Partitioning defective 3 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAR3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937571.1">
        <property type="nucleotide sequence ID" value="XM_013082117.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854915"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23058">
        <property type="entry name" value="PDZ2_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23059">
        <property type="entry name" value="PDZ3_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021922">
        <property type="entry name" value="Par3/HAL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF17">
        <property type="entry name" value="BAZOOKA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12053">
        <property type="entry name" value="Par3_HAL_N_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="299"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="561"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="726"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="867"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1108"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1231"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1290"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1381"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1532"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="867"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1142"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1169"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1243"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1291"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1399"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1418"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1533"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1547"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1574"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1589"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1643"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1659"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1674"/>
            <end position="1690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012937571.1"/>
        </source>
    </evidence>
    <sequence length="1724" mass="189215" checksum="16E161BC74D831C8" modified="2025-10-08" version="1">MPMKVIVCFDNVRVTVPCGEGDIPVRELISKAVHRYKRATGKGANHWVEVTNLKTICYGGILDPDDQLSDVVDDREQLIAVFEEQDRASIQHNGGDGASASSTGTVSPDIFHGLGEDGGPVRADGVHPAAAALAVFPPPRHNSSSSNNASTDVVVTPRDLSIGSNLRVRRGSEPSLNLLTDELPSEINPTPLSVLRPSIPRRESVRDSDEPRSESSDEDKRVKVTMHGSLDRKKLGPSRFARDAFRTSLSNRPEMFRWLEAQERQEQRTKEAQAQERTGPVDGHDGEDVNISTQPNPTLITLQNDGGPLGIHAIPASDENGKDIGLLIQSIEPERPVHRDGRIQPEDTIVEINGTSLKDVPFLRAQEIFRAAMDTKEIRLQVLKADTAIPETSSTLLPPSPKQRRAPQGPPVLPKPRSHAPMKPSPLTLPSQESEKDVKSSSPVPAPREHSKKAVPSNSSDNGQRTESFRTSDKLSSFSSNSSSSTNSGQKLESLSKPIPKRTSSASNNNVIKPGPPIKPPKKTPPAVPVRSPNTGLTPGPPTDLPLNTAYNTRKIGKKLGIQLKKGPLGLGFSVTSRDNQTDGNTPIYIRNILPKGAAVQDGQLKPGDRLLEVNGVEMTGKTQAEAVSFLRMLPEGSMVNLLVSRQEEVEEKFKVPRKMSDSSEPLATALTGLESGPEDTATAMAEGHVGAEADLPAVSLSQPSRGTEAMEDSPPGQVKEKITFHVQLNDTGSAGLGVSVKGKTEPTDQGLRDLGIFVNSVLQGGAASKDGRLEVNDQLLEVNGVRLEGLSNTAAMEALRMAMMDEGLIPGHSTVTVARRAEPNSMPFFCGDTADSSQADAMLPPPSVHQRSVSASSDLPAPIVHQRSSSASETFSSPVVQRFGSDKDMPSPIPPVRSKRVAALRERFSEMGNGLRNESYMKATNESMDVGPAGLRNESYMKATHDTLNESEAFKNLLPSPSKPVAPLKHSQSQEGKENIVIVENDTYTLPQKPQRPHSTIGFLHGGPHGSVSDDEAFRRESVASSKDESDLSPSGDLILPFAREGFGRQSMSEKRKGHLDPRSTEIYKLVKANKESKGGFLGRRVRSFHVTGATNVDVVPAVRGVPTAQNTPLSPRKGSNPAPTEAPPVSNSMMHVPDDSTYNPNRTARDSSPSNLKRSSSVEDLSHPVASQAPVSSVSSSTSVQQSRDNSPMWRTNRFGRARACNESFRAAVDRSYDALDPALMDTLEEESAESGAFTLEPSNSGRSSISSENTSEDTNSLKRRKAKEKDKKAGGLLKGFLRFGKGRKSNEEAMRRSRSEERSGDRVIDRRTDLSLERPVEKKDRWAAQPYGDAQNLGFVPLTVPQGHQQMGRRASNQEEERIEEEYARLREFHVSNQRLRSQSVDPTLGRNKLGSSSSSTERSSPFQPYHGSSQQQQILQHQLQQFQLQQQQQQQLNADPRTFHPAAVSQGQPLTGQDHRGGRQYMSSSQSSLDPGGRPNIAKAVMSRAEYIQQLRSLYQQRHRQRQGVYPLDDSEEFYEMQIQELEQRQWTPTSSDNSYDGRSSREPVRFTDRPPSRLPEDSPERPYGSTSSMVNASSSSLPHTHQHHQQQRYHQHLYNTAPHPGSRPSPRGPPSSAHDMATYYKQQQQRDQHIQHLQQHHHHHHHNPPSPHGGLRDDYELPSGHEHYNSNMNYPIPDSRSQQPFYTGPPQAYHHTAPHPYNHHYRGNHPHTDSSSAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZP2</accession>
    <name>A0ABM0ZZP2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arylsulfatase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937851.1">
        <property type="nucleotide sequence ID" value="XM_013082397.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861726"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046214714" evidence="6">
        <location>
            <begin position="34"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="36"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012937851.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57825" checksum="8A131A72B3F0202F" modified="2025-10-08" version="1">MSYDVLRYHSVNKTMMPLYFTFLFLILVATASGKPPHVVFMVVDDLGWNDVGFNNPDIKSPNIDSLAHDGVILNHAYVQPLCSPSRSAFMTSYYPFRLGLQHMVINAQQPVCAPLDKTLLPQVLKKNGYATHMLGKWHLGFCRPECTPTHRGFDSYFGYYNSREDYYVKVQGNGLDFHINDKINWNAVGNYSSFQYGDAVENVVRQHDVTTPLFLYFPIQSVHEPLEVPLRYYDMYPNITIDGRRIFSGMVSAADEVVGRLVKVLKEKAMFDDTIIFFTADNGGWVPYHGNNYPLRGGKITIWEGGTRVPAFVHGKPLQKTGVRYDGLMHAVDWFPTILEAAGISYSDPKRDGISQWKSITTLSASKRTEFVYNLDNHTTPFQGHAAIRVGDFKLIEGYPGLYNGWYKPNDSWPGEKPNPDYSDLHVQMDPYSYSNWTNFKGLYNIRDDPYEHTNLYDKLPEVVKKLQARMSYYYTMMVPANYPPKDPKGNPMNFDLWWQPGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0G9</accession>
    <name>A0ABM1A0G9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011837</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938322.1">
        <property type="nucleotide sequence ID" value="XM_013082868.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011837"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938322.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28852" checksum="A937FA52D02644FF" modified="2025-10-08" version="1">MPQCYNPSLVADQDTSAFGKNSRYMKANNFNLHTLRRVNVLNSLEAKFTRMRLSVMERNTQNQLKMRSQARVNILESYKRTLAYRLVVKKHPIRKNPDFNAALNDNYSFHSLRHEIKAMLNDIDPNIVRHRKARERVHECKDTYQGVIAQNLAKIVDIVPKKRVVPEVVTEVESRTPTPPPPPRTFRRSIIGPPLRGLAKEAQGVTLKMVKEKSWMGVASPSGQTAGSPSKTPGLINPRPALPPIQGAPHEIEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1U9</accession>
    <name>A0ABM1A1U9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850010</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939115.1">
        <property type="nucleotide sequence ID" value="XM_013083661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850010"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939115.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="17482" checksum="6BF52E106EE94971" modified="2025-10-08" version="1">MGCNTSKGAEAQSSESNATKPQPAADSQQNNEPAAQQTEKDAADLSLTPDDRVADSAEERREEIKENTTGDMSGTTSTPVFLIELHKGGEDNTSDPPETKEFIGGNGTGVDDAHDGTDDAEHRKKSSNVKFQNDLTTENEPDERQTEETPAEQTAGGGGTEAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1X8</accession>
    <name>A0ABM1A1X8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gelsolin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939160.1">
        <property type="nucleotide sequence ID" value="XM_013083706.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853797"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="57"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="180"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="289"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939160.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41394" checksum="B6ECE2DBC528340C" modified="2025-10-08" version="1">MSGLTKAKQYDWKDSNLALFGSDLERQVKKESAQTEPAWKNAGQKVGLQIWRIVKFKVVSWPKEDYGKFYNGDSYIVLNTYKEEGSDALLYDVHFWIGKYSSQDEYGTAAYKTVELDTFLDDVPIQHREVQGYESSLFRSYFKTIELLEGGAESGFRQVKPEEYVPRLLHFHGDRSGVTVKQVPRVLDSLDGTDVYILDLGLRLIQWNGSGSNKDERFKAVRYMQNVASERSGKAKTEVVEEGQDTEEFESFLNESGKTEESSYDAADRTKELYRLSDSSGKMSFSLEKKGKMAKTDLDSNDVFILDTKLEVFVWIGKKTSHNEKKNAMAYAHKYLQESDHPLVSVSCLPEGRVVKAFESALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A225</accession>
    <name>A0ABM1A225_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurotensin receptor type 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106012073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012939250.1">
        <property type="nucleotide sequence ID" value="XM_013083796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012073"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939250.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38290" checksum="5FD614BAD9A6F902" modified="2025-10-08" version="1">MSSIDYSHTPSFEQDKEPMIDDDVFNVLIIVLYVVALGIICLFGIIFNAINIYVFFKQGFKDTVNITLFSLAVSDMGNVVTLLWMSVCFNPLFAKSVLPMVYYDLSYITSGWPHTIFARISSLITVFVTFERCLCIALPLKVKAIITPRRTIYVIVSIYIGVAACAVPAFYSVSLGPKHDSEVNMTMLGIVYTANGVFIEGISLYISSVSQVASFISVIVFTVILVQNLLIKSRWRKSSSSSAKQESLSNRDMKVVKMVLSIAVIFIVGLSPSVANIFTILAVPEFNYYGEYHQIYLILWAISFLLVTTNSAVNIFVYYYMSSKFKEILDETLKKVRGKCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A444</accession>
    <name>A0ABM1A444_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chymotrypsin inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106012334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I13 (potato type I serine protease inhibitor) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940436.1">
        <property type="nucleotide sequence ID" value="XM_013084982.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012334"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000864">
        <property type="entry name" value="Prot_inh_pot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036354">
        <property type="entry name" value="Prot_inh_pot1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33091">
        <property type="entry name" value="PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33091:SF29">
        <property type="entry name" value="SUBTILISIN INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00280">
        <property type="entry name" value="potato_inhibit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00292">
        <property type="entry name" value="POTATOINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54654">
        <property type="entry name" value="CI-2 family of serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940436.1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8565" checksum="0F2773BB25DF634B" modified="2025-10-08" version="1">MSDQDQQQQQPKTSWPEAVGKTFEEAEEMIKTDNPFVKQILKVPENSPVTMDYRPDRVRVFVNEAGVTVDVPRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4K5</accession>
    <name>A0ABM1A4K5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Paraoxonase</fullName>
            <ecNumber evidence="5">3.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a phenyl acetate + H2O = a phenol + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140310"/>
            <dbReference type="EC" id="3.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the paraoxonase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_012940729.1">
        <property type="nucleotide sequence ID" value="XM_013085275.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848218"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002640">
        <property type="entry name" value="Arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01731">
        <property type="entry name" value="Arylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01785">
        <property type="entry name" value="PARAOXONASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012940729.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33174" checksum="E87BEA1C9C9F4E66" modified="2025-10-08" version="1">MSWKIAGCSILLFVLQHIVRVIYSFGYHLHYYQHYPGPCQQVEGIDLGSASLYTLPDGLTLITSGFSMNLLSPSYQAFYEEKGARGGVYMMDLKNASGELAPVPLSVVAEHSGFNPQSFRPHGISVWHDHDSGRYIVFVVNHPVREVDRVEKFVLDRGNGTLLHVKTYTSPKLRSLYDVQAVGEDSFYVSNVLYEQRSRFFMLLELFSLMPWSSVVLYQPETGYSQVVSGLTSATGLLVSPCGLFVYVLSCMGAEIRVYRRQEDNSLLLQQSYPLFTHPDMAAMDPSTGDLFVGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A525</accession>
    <name>A0ABM1A525_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Fibulin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101853570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940975.1">
        <property type="nucleotide sequence ID" value="XM_013085521.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853570"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000020">
        <property type="entry name" value="Anaphylatoxin/fibulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055088">
        <property type="entry name" value="Fibulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF111">
        <property type="entry name" value="FIBULIN-2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22914">
        <property type="entry name" value="Fibulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00104">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01177">
        <property type="entry name" value="ANAPHYLATOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01178">
        <property type="entry name" value="ANAPHYLATOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046921943" evidence="12">
        <location>
            <begin position="20"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphylatoxin-like" evidence="13">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="531"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="573"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="615"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012940975.1"/>
        </source>
    </evidence>
    <sequence length="882" mass="95946" checksum="85D83DDE160D0C63" modified="2025-10-08" version="1">MRLQILLALATLFVCCTHGDLGDIFGPCCHEGVQWSSDSFRCDNYPAPVANISDADQAPCLSIIEVCCIKQTQVVACENGKQAALDSHLCAVRDTDPGAEQFRECCHCCQLGVVSRSTSQSCESPGLGEPCDIKFQECCRGQESGNVSFSGGSHTKRSNIPGEDPDSDGASHKTSNNNNNNIPSVAPTVDDGTTNSSSSSNSSTGETVVDEDDIDECTIYSGQLCSHLCVNTALGFYCDCPPGLTLDPLDNRTCLAVDGSGVPGDNVLANCHDNNPCDQRCVEKIGGGVQCRCYEGYRLALDAMACEDIDECAENLAHCAPSQICVNTPGRFTCMSSTCPAGYDLDPSTGRCKPGKEQCALGFKYSPKTGRCEDLNECGLGIDSCGPGERCENTVGSYTCRRERHCGTGYTLDEESQRCQDNNECELGTHNCGGGYKCQNIQGSFRCVPKPCEEGYRFDRVLEECVLVQCPVGLKPNRAGNCVDINECEEYGPTICRRHQRCKNTRGSYYCRSFVNCPPGYEPTENSGCQDIDECDRGTHKCGPEQQCINRQGTYFCQCPRGMRHDNTGSCVDVDECSYGAAICPSNSKCVNTPGSFTCDCVDGLVSDGQDHCTDVDECEQEGICQQSCVNVLGTFFCSCNRGYQLRDDKRSCEDIDECTQFRGRGGRSGVCGGRCINLPGSYRCECPDGWRLKPDSRSCEDINECREGSAYCPHSESMCINTRGGYKCPVVRCPDGFIKTNGTAHKNRELITEEDGVVCGREDCKARDLACLRNKTKTVTWQFLPLPSLEFIGSPLTLLNIRTVGYSVYPNLHLGIIRGNDEGLFDTTVSGDRGALRLLRPLKGPADKEVVLELENRDFSGKNVISRHVTHARILVGDTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A533</accession>
    <name>A0ABM1A533_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Probable G-protein coupled receptor 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC101855582</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103692.1">
        <property type="nucleotide sequence ID" value="XM_005103635.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012940985.1">
        <property type="nucleotide sequence ID" value="XM_013085531.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855582"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="64"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005103692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012940985.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52119" checksum="E454FC29E0C0CE07" modified="2025-10-08" version="1">MGDELPESIYNEEFLKPLIFKHATNSNGTALIGIDSQRDKVMPLAATVVLLAAYSVLCVISTFGNSLVCYVIFKNKRLHTATNYFIANLAISDLLVTFVNVPFNISRSLLVDWPFGEVPCHLVNYSLVLTCYVSTYTLTSIALDRHRVVLKPLSRRMSRKFAVSILILIWAVAICLSLPYGMYMRVLKVKFLITTEFRRCRFIGPKPWRDFEKFLTVTTFILQYCVPFSLIAIAYGRIVQSLWARTHVGAVTANQQLSQAKAKRKSIKLLIAVVIVFAICWLPLNMYHLLTDLHPKPEMFQYNTLAFFACHWVAISSTCYNPFVYCWLNENFREEVKSRFSCLFRLPCGRGLRSDSASTKLEGNYRKVKNGQGSVAASSVLNRSVRRDPNTTATEILKNNVCSTHKCKECDVMGVHNNITPTVDDDDMNTDFTDEAAQGLILTIECNGQGTATYQNGIRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5N2</accession>
    <name>A0ABM1A5N2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-antigen protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941305.1">
        <property type="nucleotide sequence ID" value="XM_013085851.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849947"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="33"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941305.1"/>
        </source>
    </evidence>
    <sequence length="936" mass="103733" checksum="DA165EB3B9FF86FC" modified="2025-10-08" version="1">MARKKGKGKGRAARNAKVNETGDDRDERFSKAPHSFVFHRGHVGKTVKELVSDTRKIMEPFTASRLKVRKRNVMKDFLTIAGPMHVSHFIVFTKTDIATYMKLICVPRGPTLTFKVCEYSLSRDVLSFQKHPDVESKLFNNHAVMVTNIPADSMENKLMNVTFKNMFPSINPNTVKLNNMRRTVLVNYDKDTKTVEIRHFTMKVVPTGISRAMKKLMRPKLPDMSNHEDIADVFLDRGMSDSEGEQDGPHSQVTVSQKIKDRGVARNATNAIRLKEIGPRLSLQLIKIEEGFEGGNILFHALVQKTPEEVEALKAIKLNKKKEKLARKQRQEANVNKKKEAKEEQIRKTVEGMERKKLETGNDDDNDDEEEEESDNDNDFVVDDNIEGESDDRSGVLGFGTHPKRARARDRKKVIMTSVENGGDDGKLIEGPYSLKTGKSERDEEDEGDEEDAEDEEEDEDSRYEEEKENKEQESSPRLSGQKISGPTQGWGSRNARRSKRRAEPSSNSASGSGVREGGEREGVREERKRAGVREGGWRTGVRGGQGAGDAERRQMRRIYQLLKSAHFNKQAGGGSKRANSSELEGIMGHYTGSEMDELAAKGDSRLRNEHVTGADRSDAAPPRGRKAKGRNGENKDIVSDRSRVVPPGVTGLGSNSGVANVGDVSNGHGLTSGQNRWNGKETRLADSPVAGLTDDVEGTAGHGSLPPRPGEDVYTPGWTNDLTRKHVSQATAAPLRGEINDKFSTRNSLFPSQLAARGTWVETLNKTWPLGRSRGDAKPTGGEGEKINSLMMNDDVRVVSLARAEDRAGEGGEGDDGRGCVLDYRDDKFSGEKLPDEVYGRGLGSPRRFEQRSKDTSDHSGKNAGLLLPLGNGLLGNERPSAKFDELPRPRLKPLRGQSAVTSIERKPNQRHNPRPLNQKKTQSRKPPGLAHHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6F6</accession>
    <name>A0ABM1A6F6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb-like protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941712.1">
        <property type="nucleotide sequence ID" value="XM_013086258.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012659"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941712.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="49140" checksum="B1CCD4B6CCE005F1" modified="2025-10-08" version="1">MRFNSWKGYVTPFLFTCLFLYAGAETRNFLILHSSKDGLRELRISHRSKQLMETTDGSPLSTGSLAFTRVTDGFRLVESVYRFGLLTDCVVSTSRRDIRSFISEFTRVLPGKFDSTVDEIATVYHNSTHARDFDFDIKSGNGNSTADVDSVISLPHTSDSHSNNNGLHNANDETTFLPSLGASSSTTTTTTTTTTITTTTTTTPQWKLSAKLSSNKHHKEFLNKYRDLMRIRKRVRECQRFHEEAEYRLLVLSSPSVSPSISSEVTAANVSNSRGEKMYPTFENIFTNAEERDSFLEEMGLRQHSGTPKHRAQNLPQRRNHKNPRHNHHRHRHHRKQSHHHQNRPNGPERRRGHDAETTEKHQSSYVSFDTFSARKDNNKDSENIPLPSPPLSTDSSLTSLKAAHSSFSSTLPLSSSSSSSASASASSLSASASSASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6R6</accession>
    <name>A0ABM1A6R6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Complex III assembly factor LYRM7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">LYR motif-containing protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101850503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UQCRFS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941920.1">
        <property type="nucleotide sequence ID" value="XM_013086466.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850503"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="10">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012941920.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13875" checksum="C5C2DE95A94F08E6" modified="2025-10-08" version="1">MNTMVPILAAFKDLHRARKQVFDGDAHALAETRNKINQEFRKNLSEQDSSKIDELLVLAGDVSKLLRTTVVQLRQKDDDTYELRVTKDTEMRENTLFDEAAQIPPKPRRKKCSDAQDSSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7H1</accession>
    <name>A0ABM1A7H1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nicotinamide phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16149"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.12"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:16151"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_012942330.1">
        <property type="nucleotide sequence ID" value="XM_013086876.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858297"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01569">
        <property type="entry name" value="PBEF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041529">
        <property type="entry name" value="DUF5598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016471">
        <property type="entry name" value="Nicotinamide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006629">
        <property type="entry name" value="PRK09198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816:SF1">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18127">
        <property type="entry name" value="NAMPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005943">
        <property type="entry name" value="NMPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinamide phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="178"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012942330.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="53711" checksum="B979277C25794BA3" modified="2025-10-08" version="1">MADLAAGLDSVLLIADSYKVTHHRQYPPNTSIVYSYFESRGGKFPATCFFGLQYILKRWLVGQVVTREKIEEAREIFQLHFGQNVFNEEGWNYILEHHNGYLPLRIKAVPEGTVVPTKNVLFTVENTDPKCYWLTNYFETVLVQAWYPMTVATNSRAQKEIIARYLHETSDSTAGLPFKLHDFGFRGSSSVESAGIGGMAHLVNFQGTDTIAAVTTARKFYGCPMAGFSIPAAEHSTITSWGVDREKEAFQNMLTQFPTGLMACVSDSYDIWHACGKLWGEELKQLVEDRGENGTLVVRPDSGDPSEVVIKVLNILGEKFGTSSNTKGYKVLPSCVRVIQGDGISYETVAQILENLKKSKWSTDMVTFGSGGALLQRLDRDTQKCAYKCSYAVIDGKEVSVFKDPVTDHGKKSKKGRLTLECHNGKFVTYEEGKGDPNKDIMQVVFENGKLLKDFDFAEVRKNAEIDLVKKKSDSKLDAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7I8</accession>
    <name>A0ABM1A7I8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cubilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101862086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942353.1">
        <property type="nucleotide sequence ID" value="XM_013086899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862086"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046096651" evidence="4">
        <location>
            <begin position="24"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="158"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012942353.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34131" checksum="CFC1FEF7B15DCE29" modified="2025-10-08" version="1">MTSIPYLVLIMTCLAGLFWGASCEGAYSGNFLIENCNWRRRHFLNNLGAKVNVSIARFADHNLSRNLTCITNIYALEGYLRLKVSRFSLLGSSSCRTSSERLKIFHHGLQTNNYITWCGETYAEELYFKDTVVLEYNTGLHGEGDGFDIEVSRVGRPCGNVQTLAVTNKTRLLYSPLYPDPYPHRLDCYYRLLGPGKNLRIRSLSHDIEWDETCDYDVLQINQRKFCGSEIIDVLETAQSTDTSVTFSTDGSYAGAGYVLEYFNEQDLSVVCDGDTSLNPIDLQGGENSHFIELKIKQTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8M0</accession>
    <name>A0ABM1A8M0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Uncharacterized protein LOC101845423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC101845423</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107343.1">
        <property type="nucleotide sequence ID" value="XM_005107286.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012942926.1">
        <property type="nucleotide sequence ID" value="XM_013087472.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845423"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="309"/>
            <end position="338"/>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="367"/>
            <end position="394"/>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="395"/>
            <end position="422"/>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1362"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1390"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1454"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1482"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1510"/>
            <end position="1537"/>
        </location>
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        <location>
            <begin position="1538"/>
            <end position="1565"/>
        </location>
    </feature>
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        <location>
            <begin position="1566"/>
            <end position="1593"/>
        </location>
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        <location>
            <begin position="1594"/>
            <end position="1621"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1650"/>
            <end position="1677"/>
        </location>
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        <location>
            <begin position="1678"/>
            <end position="1705"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="159"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="630"/>
            <end position="657"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1059"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1293"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1429"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1300"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005107343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012942926.1"/>
        </source>
    </evidence>
    <sequence length="1740" mass="194402" checksum="CA087708F1D8ADB9" modified="2025-10-08" version="1">MATNSSLRTADGREWADENLKGVVKSEVIHADNVILSDCRASDGENVRDQGLNVSHKEPEGRVMRGRRKAQKMDVVSNDEQQPMRTGARKSLQVGGDSAVEESDEKDGNKSSKGRRKRKDVRKVPAVRKSSSGTQKLKQVQQKIIEETDEKPDKQEVKSDGDHVCSICSRKFRSKNLLNRHLRTSTHTYDKSGKKEHRCEICDKTFRYPSLLALHRVQHEEKKPHQCELCDKSFARDTYLRMHMLSHTGERLYKCTECDKTFNDSTRFKDHKRMHTGERAYKCDLCGEEFFFKQNLKYHRLSHTGERAFKCDFAGCTSKFKTKDDLKKHQRTHSTDRPWRCDKCGKAYSEKRYLLRHMRKHTGERPYKCEICGAAYALRNGLLTHRMTHSEERPFQCSFCSKQFKYKNCLNAHLETHTSARPHKCETCGVTYKSRTALLHHRRNHTGKQLYRCNICDQGINTKDNYLSHMAKHTGEKPFTCETCGKTFRSVRSFREHRVVHSAGKQHVCDVCGKQYVFLCQLKKHKLIHREERPFACHCGKAFKTKSNLVCHEKRQHRGSSMFTCSQCGQNFAQQEALTLHVASHGDLPNHTCDICCAAFMSAESLRRHRNKHRKVVPCLDSIPQVDLTQQQQNQQPEMYQPQQHSHQQQQQQHAYQQVCQLHHTQLHHDNYSQPQQHLCTNSGVSSFPSTSSDVNLVEKPPMISSSAVVSELPSNATFPRDITVPQYSSTAKSSILNGPLHLPHTSVPMNSTSSETEANGSLVATLNNSFASEATQLPRTSLLPCDSISRPAQTPGVTQLSVSSQESLSVQDGHLPAAQLLVPPVSLPTTMDYDDSGFLLRPGSSESAPSSHSCAIFPRSAAKNSHLNEAPVSQTSAVAAAPSPSTPLPSFASHFVVGAGLEHKASGSSSNQGVSWNMKQNVCSTTARVSNCGTPMNQCRDMLEGNNGMTDLKGNQEALFETSQGLDTEQQQGRTLQVSGLASSAGQQSGTFQETKQVSNVVLNQDCDRVQYQDSNTAVNDVLNVVQNHGHTTLNQKQNSTTSKIGRSPPVPVHRVSLDQGHSSHTEPCVTSHPNTDVSHSKDGTEANLVFINLDNSSQNLCRSNGDKMGGGDIPRVSERQQPVQACGEDHVDIAVSQPPAGSHSASSSDTGLHILPETAYYVNSTEFPGATHTPLNQYPAEYMTPSGQPQNEPIVLQVGSKSHGLGVSNYEGDTIVRKDTYIDKSIFRPNESGQVINVTENEKTFLLLSEREKQLTTTDENVTDRSGDSLKDVSNSVMITDSVRNVACSPATVDDKSSNMNPTEVSLMSRTTVPVDSSSDDTMVLCLDDPASSLGASETSAERAATVLVQLAESTLRRKYKCRFCDRGFNKQMYLNDHERQHLLGASHSCDVCGEAFYSLSDLNFHMQEHNEQEDEMDDELEELNAEPASVTSGKGGRKGGQKDGDSRPRPFKCGVCGKAYFERTNLRRHKRTHTGEKPYKCDVCGCAFALRNSLKAHLLTHTEERPFQCGICGKTFKSEWCLKNHFKTHTSERPYKCEICGMTFKYSTGLNQHRATHGEEMLFMCSVCGEGFNVQYKLTSHMIIHSGERPHKCETCGKAFKTKGSLNLHRKLHTGEKPHKCDICGYASPFIGRLNAHKATHATGRQWSCFCGKSFKNKKTLVMHQHRQHPGQMQFKCEACGDRFASVEDLSIHTAQHTNEVAHRCQVCDAPFKTLQLLHRHQKGHRPTNLYKSASVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA14</accession>
    <name>A0ABM1AA14_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amine sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943701.1">
        <property type="nucleotide sequence ID" value="XM_013088247.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013194"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943701.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13534" checksum="693FB20339C2E10E" modified="2025-10-08" version="1">MPVCKVADSAGDTMDLYVMESKPQFFVVPTLKQDWVENIPNYPLRNDDVMLCSYTKSGCHWVWEMGRLLLDGRTKVEGTEKESSMVEANTLMGNIEDAPAPRILNSHLFFDHLPKDVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC05</accession>
    <name>A0ABM1AC05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Succinate dehydrogenase cytochrome b560 subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101863389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944824.1">
        <property type="nucleotide sequence ID" value="XM_013089370.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863389"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.540">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012944824.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19259" checksum="D5E4F95B2BD55E01" modified="2025-10-08" version="1">MALALRTLGRSCLLRQPSCILPRRSTLATRPSAYEEMNTYWVKNRQLNRPLSPHVTVVQYHVTMVVSITNRVAAVALQGGLCLASITLLCLPGTYTDYISKLRELRLGPAIVYGVKFLLALPFAYHLVAGMRHLVWDMGYGFSKPMTQKGSWVVLALTGACTAFLMFGVRPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACA9</accession>
    <name>A0ABM1ACA9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Immune-associated nucleotide-binding protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101857525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944975.1">
        <property type="nucleotide sequence ID" value="XM_013089521.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857525"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF184">
        <property type="entry name" value="GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012944975.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27163" checksum="4307814F16A02647" modified="2025-10-08" version="1">MASPTKPCFDVLLLGKTGHGKSATGNSILGSRTFKVSSSTSPETSEVSKIWTERDNCVIKVIDCPGIGKTRLDKPEAVNKAMEDLSKAMITCPGGLHALLFVYKFGSWFNEEEQARIDFLKGVLGKDVFEKYGVCVMTNGDNFRGAMEEEETPQKTPLVWCREQNNTFSCLVKECGDRLVMFDNRSKDQKIKHDQVEELVKLLRALPNHELYTNKQLTQMHKEREKLTLKTKLPQMEEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADR2</accession>
    <name>A0ABM1ADR2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen alpha-1(XXIII) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945734.1">
        <property type="nucleotide sequence ID" value="XM_013090280.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850863"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045823563" evidence="2">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945734.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19158" checksum="0D7A90C06724F5F3" modified="2025-10-08" version="1">MRQFLCSAVLLAAVASLTTGSRLSNEVISRAMNMEDVGIPLSQLESLTEHQIDDIFTTLLVEEGYDLQDLESAPPGFLELILEGRKGGKGGFPGPTGPPGPEGPRGPDGADGRDGAPGGPGPAGFAGKAGDIGDRGTKGSKGDRGPPGPDIKLDPKLVKKVYEIEALLNDFQFMFSYGSFGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADX5</accession>
    <name>A0ABM1ADX5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vegetative cell wall protein gp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945844.1">
        <property type="nucleotide sequence ID" value="XM_013090390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013772"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945844.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="50324" checksum="143E4B5E91E57094" modified="2025-10-08" version="1">MWDVLKEYPAARVKLEAIAVKRLEKYKKAPLEKVSMARSRSTPGLVESTGKTPLDSMIVHRHHTLPVGLIHKDGSGTGGVGGTSGGVVPVGGPREDDHSLKALINTQSEDNLISRCAGEPRRFSSDSTHHAGNMTTSMTISSMTSYCGTPPQRSPNVGEGGPAAVIGPAMVIGKNPFSSPPSPKILVRSDTSVVSSAPLVNGHPSLSHLTPHHGAPPPQPVSPAAAAAAAAHAQYAYQNLTFINPAAHHPHHPHHHQPINFLSPFCTPPPPGANYPASPSNFPASPAGFQGSSPGPGLIIPQAPSTPSSHTGMLPSPLATQATPPLVSYPSHPHSPALLRHASTHLGTASPSTTTAQLSQLLPSSYVHQPPAPAPAPAPLSSSSSLQHSPLPQRDEGQSEMLLKEITRLRERLAQLEGENSALTVKLNQQQWDVESRLTELEMHICQSDSVASTEFDGDSLRQDSKSTPPAVNRESII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADZ9</accession>
    <name>A0ABM1ADZ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tudor and KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945877.1">
        <property type="nucleotide sequence ID" value="XM_013090423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858322"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF18">
        <property type="entry name" value="TUDOR AND KH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012945877.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="54285" checksum="96AC1A0114181C41" modified="2025-10-08" version="1">MPSVGVVGQVCAALLLPAGSLLLYWLYRRSAPSDEEVYGGQRVVTARNTVLEVCVPQRAVGAVIGRQGARIKEIQKSCGARVTFKDRGVGDGDGGSHRVAVIYGTLDAAHQAELLIQQVIAEVKEPITEQVDVPGYSLGRIIGKGGSSIREMCRVSGARINVDRYEGSADPRALRTVTLTGSQQQIDVALEMLEEKLEEEEKFRDKMSVMAANREGRSLPPQREPLKVTSVAVKETSWEEEEADAATLRQEKLPLTDGYVEVYVSGVEHPGHLWLQILGSKALHLETLQAELTAWVSTPEARTKFAVTSVTPGQLVAAQYEPDDPTFYRARVLGEVVGESVGESVGLLDLYFVDYGDNCLAPPSRVFQLRSDFQSFPFQAVECGLADVIPTGGESCEWEEGTVSVFEDLSQCARWKTLHARVVSHATRGQLLPLIELLDCSGEQTVNIGQELVRRGLAQRSQVSQSQDTQSQDTQSQDTQSQDTQSQDTHSDARGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFD1</accession>
    <name>A0ABM1AFD1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Colorectal mutant cancer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946587.2">
        <property type="nucleotide sequence ID" value="XM_013091133.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852150"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040171">
        <property type="entry name" value="USBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347">
        <property type="entry name" value="COLORECTAL MUTANT CANCER PROTEIN MCC PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347:SF6">
        <property type="entry name" value="FI17904P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012946587.2"/>
        </source>
    </evidence>
    <sequence length="552" mass="60535" checksum="7218BB4ADAFAEC8F" modified="2025-10-08" version="1">MMAERGSSSGSGSENGDSRNSSSRSSASEEERLRRLFNSCDADGDGYLDGEDLTFMCRMLNMADSVGEVRQQLGLTDESRLSFHDFLRCRTRVMLESSALQQPHQQSQAHDLEAVTSPALLSAGEDTGIESDASGVMGNVQPASQMTLWPTLSSDSLGALSCTKPDSADYDSGARDLSPEPVTMTLTQLMDTHDPQAMAQLRKAGADSLLDIADRLHAAALTSLKGEVIELKNHMHRLTSDRNLLDPQKQNHPENKLGPSDFEDRLEQLTSRYEERIIELHSVIAELRKKLERHQINVIREEEEYEESEQGQSTRSNDGESLNEKDENAEICQEFSRVVSEIQTAMAAKPLETPPSGGREEDEEERRRKASQDVPREEGEEGDQSDPAKPSLSETPGSEPPPELPPRAARPCTLPHGNSSATFTLDPQARSEVGVLQADNEELRRQTSQLEVELGHMAGKMAAVVREKEALIGKVYDLQQHLQTVTSATSPSHSRVATPTKQTVTPPPPADRRGSEQDNFPVAKIAELKKLRTCVGDMQGILGSEVAMMGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VNP0</accession>
    <name>A0ABM1VNP0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine N-acyltransferase-like protein</fullName>
            <ecNumber evidence="1">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_035824032.1">
        <property type="nucleotide sequence ID" value="XM_035968139.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860479"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010313">
        <property type="entry name" value="Glycine_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015938">
        <property type="entry name" value="Glycine_N-acyltransferase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298:SF1">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298">
        <property type="entry name" value="L-COA N-ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06021">
        <property type="entry name" value="Gly_acyl_tr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycine N-acyltransferase N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035824032.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40088" checksum="64658C67BBF6EEFB" modified="2025-10-08" version="1">MSVMYRTLTAEESQDLRWELHSSLPGSAKIYYVLSNHMDNLLTGFEVIVDQWPNWTCIMLRPKSFESVPRYFRHYHMCHTKSTKDFKFFIQRPCVVDWTKPAIFTGIPYDVVPVIQDKSRKEYGEVTSVEHRFMYAWTKSDPPEPAVAPEGMQLTELKKEHAEMIRDHWKHYRANDGLVEYFQQVIEQFDNSAITTTDGELVAYICMQYNGSMANLFVDPAYHTANLGVLLLRDLTRKLLEKHQTAYGFIKTKDSAFITTCQNIGFSWVPQGSMSWVNHKPRVPGSRSPLAKVPSANGLSTSQEEKDKQDGGDSELEVKDLFLTALPLSCNKCSGIPEEKRKGACIHVGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQU6</accession>
    <name>A0ABM1VQU6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand calcium-binding domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824788.1">
        <property type="nucleotide sequence ID" value="XM_035968895.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857710"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015070">
        <property type="entry name" value="EF_hand_DJBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF5">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08976">
        <property type="entry name" value="EF-hand_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="784"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="899"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035824788.1"/>
        </source>
    </evidence>
    <sequence length="976" mass="112275" checksum="A05317B8F125249E" modified="2025-10-08" version="1">MSQVGVFSRPASQMKVGVSLPEIKHPLAQMGNPGTMDVRGVSRASNGRPFSNPPMSGRPMAAEGNMARKSFSATGRESKASARNKENMMGNPIPIESIPEGVEVTYGDPAATRLPVFGSRAGLGDRDNQSRASGRMSRASTQARLEIDELEASLKEKLRNNYYDVRKKFKDNDPEGRGNVSREAFTRILVTVLGRSISGNTCQRLMERLNFAERQVIPFTEFFSYFREAQESTYPQWMDPVHRANQDRVIMSSGQVHANLREKAKQRFLDLADMIPQMNPGGSGRIMKSEFRQMLNRMNFYMDDTEFEKLWHRYDPANEGIINGQRLLNNLGIEWRGGSRDMPSQVSPFQDQPQPQGRVTVATNGPGKGSVRLTPIEDEIAKTERSERRTPRKKEVERRQQLDIERWLKNKFREGFFNMREAFEDKDPSRSGVVTFDDFVEVLGQFGLKMEKNLLGAFLSRCSVKAMGKGVPYREFLHRFQDRGDEGMTHNVLTDVKHRYNNRAGSPSVNSTISAVETQLTNMFQRDFLALLGMFKKIDHLGTDAVSQEEFRAAIESRFNMDLTDGQFHAFIDRVPLDEDGNVLYARFMQQFDAGGKAPSLYAPRPDMVDPDQMKMPAPPAQMDSPPPENDENMTPLPTAVVPDVESEELHRRRTNQELFKAIKDLLNRRFQEVEQCYYDLDDTNTRRITQEMMYQLLRSFDIKPEISRGEIRDLWRTFITNTDRTLDYLQFIRHFGFSMRSAAFPNAKLHPPRRGDADFMIRSRKLNCAADMLQDNLRAKVDYLWDDLRREFVNMDLYNTGYVTNEEFREVLTELCVNLSNVELEQLINKFEVKKDGRISYIEFLKPFALRKQTWRHGNNMLSLLQHPQPELPIADIVEPPQKGLHGITAKLRHKLAGDWKNLRRAFRKLDVTGTGYLSLPEFRSVLKLANVILDEDEVYHVMTEFDRDLTGKISYEKFIEETFKPETRQSTRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRC2</accession>
    <name>A0ABM1VRC2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Poly(RC)-binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824964.1">
        <property type="nucleotide sequence ID" value="XM_035969071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847575"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22438">
        <property type="entry name" value="KH-I_PCBP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02396">
        <property type="entry name" value="KH-I_PCBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="184"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="389"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035824964.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="59782" checksum="A5A5C556C826F626" modified="2025-10-08" version="1">MYVSNMWAMPFEDGGFTYCEYGAFRAPPLPFPPLPGEIPEMTDTAGLIVATNGPISTNHHNHHLSNTNGNSNISTSPGSSSSSGSSPNNMVVSVDGATTTATSTILTVRMIMQGKEVGSIIGKKGDNIKKFREDSGAKINISDGSCPERIVTVTGSTDNIHRAFGFICKKFEEDLQNTPTTPKPPVTLRLVVPASQCGSLIGKQGCKIKEIREATGASIQVASEMLPNSTERAVTVSGTADAITECIKYVCGIMLESPAKGANLPYRPKPLLSPVYISSSQGFTLPSGVAPLPGGPEQMPKGLPHPVQMAHAIPMVPSAQTVVPGSLVPVNGLGPAALPPLSWPGPLPPPPPPCLTHLLIPSPGLGPSLQYNPRPSNPGPPPPALPSPGQQAQEMNIPNDLIGCIIGRGGQKINEIRQVSGANIKISNAEDGSSDRKVTITGSPECIGLAQYLISTRLWLSMELHKTLTLDPASLPPVSSVAAPLPPLPPHPVAMTVMKPLPPPPMLGLNGLGQLMDPAAMAAQVPNSMAIACSLPGAAPMAERKPLTTKMRLGLTATTAFKAAERPKFTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTQ3</accession>
    <name>A0ABM1VTQ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cocaine esterase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC118477719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825795.1">
        <property type="nucleotide sequence ID" value="XM_035969902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477719"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046138253" evidence="4">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035825795.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16175" checksum="630E326A6ACC3ABE" modified="2025-10-08" version="1">MATTWLLQAIFITVLSNEILQTRQAATNSMFLLANTTSGTLRGRVDSGPSVPVAMFAGIPYAKAPTGPLRFKAPASPDKWTGVRDALVFGDECLQRVAANDAFRDPNAPHSEDCLYLNVYTPTKRTSNAPLPVMVFIHGGGYNSGNFDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUG3</accession>
    <name>A0ABM1VUG3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101857878</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826055.1">
        <property type="nucleotide sequence ID" value="XM_035970162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857878"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045317218" evidence="1">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826055.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16893" checksum="B6841C64133405D1" modified="2025-10-08" version="1">MYQVGVPMALPCKLAHCIPVIFLMVLSLSVNCFGTEDFDCLDEWSEPQTVQESNTYFLENETFTVTCTLPACNRYKGFTAGDIGFYLEKRGAAPQACIPMSLVSVQNVTTARLTVNVSVEDAGAFACIVPNQNCSQALQARHGFKIVGYTNDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUG4</accession>
    <name>A0ABM1VUG4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl 4-hydroxylase subunit alpha-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118477814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826056.1">
        <property type="nucleotide sequence ID" value="XM_035970163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477814"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046610126" evidence="2">
        <location>
            <begin position="30"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase N-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826056.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="53317" checksum="97B1D7B7C11DFBB2" modified="2025-10-08" version="1">MATFPGVSTKLHWFLLALVVSYTTLVCQAKYLKDDRFMSDVNLEHYYVIEENVLSHADILLRDDYFGADEEEDEEEHIAHAPNLTEFRSIVTETKAVHREAGPNLQTYLSHPINMYHMFRRLSTKWKEGLDLLLTTTPCKKWNIPSIAGRLQYLRDNLPGEREVARAVARVSLLQRIHGLSAADVTQGKFGDLMSLKPLTPQEQFEIIGVLREQEDMQTALAWLEQVNSWMVKSGTTGGEELGFNRTHILLMMASAHYLLKNIPDAFKATEDALKLDPDSVVAKNNLDFFKEKLSSSTFPDDDGKQATKYRSRYERSCAKTKRVKASRKKCTLTRVGLTFLKTEVIRRKPRVVLFHDVVSNISTDVLKNYAHKTQTDKAWVGDERYVAPDFRVSLHPLRIRGSAVKRKTETLRRQLQFLAGVLNVTSDRWGTTQVVNVGLDGMHFSKHDKDLGVNASFICSVVQQDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUK8</accession>
    <name>A0ABM1VUK8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Histidine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101861511</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100122.2">
        <property type="nucleotide sequence ID" value="XM_005100065.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826100.1">
        <property type="nucleotide sequence ID" value="XM_035970207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861511"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403">
        <property type="entry name" value="LOC100145250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403:SF6">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100122.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826100.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16163" checksum="94F3C420AF63208B" modified="2025-10-08" version="1">MTSEVVIRPARMTDYSSVVEGIGDVYWGRDYLPAKYTEFLQDPDFLCFVAEVDGEVVAFYLGELVDNRQTVDKRAGRVKDGYKGQGIFSKLSDTIEAEVTKLGTVKWEVMACEKKVAERVSKGFTEKKGFELIVHVVRTSQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVX6</accession>
    <name>A0ABM1VVX6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101863753</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826568.1">
        <property type="nucleotide sequence ID" value="XM_035970675.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863753"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826568.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28753" checksum="E1AC042D683A6FAC" modified="2025-10-08" version="1">MRDRATKAPVSSCYKHSPRVKPAPNPFTAELHEFEMTKWRETFDSMGGLSRAGKQDIKVVDTLRKAPYHCPSLARRFDAHFGKLSRVSLTAKEVKKLPDKKDAKRSACNNIPISHMPVVRVMKQPKSWISRPPDETNVTVHELPVTCVLVKWGVGTSPSRFTCESLCEWLSGFGHVLFTIPEGDHSLFAAFDSIMSAYSVTWCHPKFSNFGQLQPMKNYKLSADPKWRSLLLKTQPKAERKSGARPQAQEEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWH5</accession>
    <name>A0ABM1VWH5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase/oxidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826767.1">
        <property type="nucleotide sequence ID" value="XM_035970874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478017"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826767.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27509" checksum="33904C27FCAA789B" modified="2025-10-08" version="1">MVEVTEAGLRVGAAASIQGLRPVVRAIIEELPEHKSRGFAALLETMSVFASTQIRNVASIGGNIVTANAVSDINPFLLATGATLQVMDTEGKTRDIAVEEKFFLPNGQTSLSRGDIIVSVLIPYTTEGEFVQVYKQSSRGEVDRAVVNAAMRLVLTSDLQIVSDVSLVFGGMGDRPLLASRTMKALQGRKWDRSLVEFACSADMLPSDLPLAPDSQGGMVAYRRTLTLSIFFRFFLSVSEKLGRIWIEKRPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWR8</accession>
    <name>A0ABM1VWR8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">5-hydroxytryptamine receptor 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101851588</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826860.1">
        <property type="nucleotide sequence ID" value="XM_035970967.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851588"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="222"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035826860.1"/>
        </source>
    </evidence>
    <sequence length="655" mass="73343" checksum="90E4061C9FD05836" modified="2025-10-08" version="1">MPRVLHDLQEGICPLCGYGSLYRAGSWGIDIVRTLSANDHFLNYAILSIFPPRNPVFYVSIFICLSLSVVGGSFVVVTTPKTYSPDSKTSLEDSLISTGKQKPYHPDNQSAVTRRTTNILYSLYGIADRRTENMTSVSASAAVTPPVLYTPMNSTDVYIPYGINGSLYVNTTSPNGTDLFGNITNTTLAPPEDEQPPIPYQQWEQIIVAVILGALIICTIIGNCLVCISVAIVKRLQSPSNLLIVSLAVADLFVGMTVMPFAAVRQLYGSWILGTIVCDIWTTTDVLLCTSSILNLCAISVDRYFVITRPFQYAMKRTPKRMGLMVFIVWTVSAVVSIPPVFGWKSPHKPYDCIISDDIGYQIYATLCAFYLPLIVMICVYFKIWRVSSKIAKAEAKSKIGSFDKGAEFQLGRPSHDSGDSSVMPNGCLRDGVTNGGGGDDDGSIEILPKKLEPEKSSRRRFTIRSLIPRQPKLSNTKERKATKTLGIIMGCFTLCWLPFFILVLVSTFCRECQVPMELASVLNWLGYANSFLNPVIYARFNREFRTPFKEILLLRCRGINTRMRSESYVEQYGPVVSHRDSLRPPTDSVVRYNSQGQTVVALGNANIIWFQMSYLFQYRKKIQNIRQRSNNCFLKESCSYQYIYTCTTWFSLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXE8</accession>
    <name>A0ABM1VXE8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847278</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827091.1">
        <property type="nucleotide sequence ID" value="XM_035971198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847278"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827091.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21494" checksum="D69CCF27993CA8BC" modified="2025-10-08" version="1">MGIYTKSVKENSDSEAPNKPGSDVESVVSEGTVSDGSGVLLLPKEIRPKTNQKATVVVQKDAGLAVPKRGKSGVRQLRFRRERARATCVRVLCCLMFVCSVAVVIVSAVGLLQHLRLFPRLGYLPFVGRVGPVPHGPVPHGSDGYHRHLDLTGKVCAKPLSMTVLAVWSVFLLPLLLLPMLLLPSLICGISTKNPKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXG5</accession>
    <name>A0ABM1VXG5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101855204</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101855204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827108.1">
        <property type="nucleotide sequence ID" value="XM_035971215.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855204"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="48"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="381"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="774"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="807"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="840"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="1073"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1189"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1222"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1260"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1473"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1539"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1619"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="1771"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1887"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1920"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1958"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2126"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2206"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="2358"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2474"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2507"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2545"/>
            <end position="2572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827108.1"/>
        </source>
    </evidence>
    <sequence length="2673" mass="298467" checksum="6473653897232B3D" modified="2025-10-08" version="1">MALTRCIIRQHRMDLTEDLHQAIMNDKDREAIELVKLGADVNAVWDHETAFTRAAQRGHLEVMQAIYACPGFDPNAMNSCGKFPLYITANKGLTHCVEELLSLGADINLQIPEGDTPLAACSYDDCHETAQVLIRHGANIDTRDVYGITPLYLACSFGSVNCVRVLTESGCDVNIVEKEPRITPLMKALSLLRNSSEPIDKKISDVLEICQMLINAGCRLDDEDLDEYTALHHVVENRDVFGLCLLAESGCNLETHDENCQTPLKKALDDKEPVFEIARFLVYYGAKVHNESFLDCVHDYSFIKMSALAWLIEKAPFSDEHDELRERYLLLKVLREATYPHFCCTPSELDLPQDSPNQHFVDKYMAVEREATDWMCSLESPVSLEFQARVKIRKMLGVRNTLSKIDSLPIGKYLKSYLMLGLEEELPLSRSCMVHAYIRDREHKKLKDLVQSGANVNFMVHGKTPLAAAVILKNLKAFRILFSTGRAYIGQHPVNEEGDTPLHLAAAYGFVNIIDNIIHAGGSVKAINLDRYTPLVSAVTAGHFEVASLLIRRGAEVKGQETLGYPLLHLAAASHNIEVVQMMLERGIEANLRDHQRNTPLHIVASQAKIYLDQNVYLPALHTSDVEAAEETSDVSTSSDEETEYDMNKNSPEARRTTPGKEKYQDVARLLLEHGADVRAYNSESLTPLDVVEKGDDPVLVDILKNITMLQDLHKALLSNEVEEAKQLIESGADVNAVYLQETAFTRAVKLENLEVTQAIFARPDFDPNAKTWTGRSPLYITASRGLTRCVEELLSLGANVNQQNPGGETPLTACCSDDFNETAQVLIRHGANINTPDFNRINPLYRACHYGSVNCVRVLTDNGCDVKIVEKESRNTPLIAAALSLLRCRNTWTNKKISDMLEICQMLIDAGCDVDAQDSIGRTALHHVVEKRDVFGLCLLAENGCNLETRDENQQTPLKKALLDEEPAFEIARLLVYYGANVHDEIMVNCGHGEVGKSPLAWVIEHAACSAQHDKLRERYLLMRVLMEATYPNFCGISSMLVLLQVSQNQQLVDQYRAIERETVNKICSPVPASLEFQARLKLRKMLGVRNTLSRIDSLPVWKYLKRYLMLGLEEELPLSRSCMVHVYIRDREDKKLKDLVQSGANVNFMVDGKTPLASAVMLRNMEAFRILFSTGRACIGQYPVNEEGDTLLHIAAANGFVNIIDDIIHAGCTVKSFNNTGFTPLRSAVTAGHFEVASLLIRRGADVKGQEMMTVPLLHLAAASRNIEVVKMMLERGVEANLRDHQGNTPLHIVASQANIYLDQRMCLPALYRSNFKKTLDKTDINLNGNKDRPTVPGKEKYQDVARLLLKHGADVRAYNSESLTPLDVAEKGDDPVLVDILKKTTPSPPHPPQLPECHPPKDMTMLEDLHKALMNNKVEETKQLIESGANVNAVCQQETAFTRAVQHENFEIMDMIMECHDFDPNAKNVFDRSPLFVTARKGYTLYVKELLSMGAYVNQQDAQGVTPLGACCWEDFHETAEELIQHDANKNTPDLNGETPLYRACFHTSINCVRVLIEKGCDVNIANRSGETPLIVALPPILYSDIMSMEENISVMLEICQLVINAGCNLDAQDSRGRTALHYAVESGHVSGLCLLAEHGCNLEICDEKRQTPFQKALLDQTPAFEIARFLVYFGANCREEISVRRRSRMEMKSPLALAIEAAPLESPRRKLRERYLLLRVLMEATYPYLGGLSTNLVLPQVSNIPHPVDPYRAVERKSENWMLSRIPASLKFQTRLKLREMLGVRNTLSKIDSLPIGKYLKSYLMLGLEEELPLSRSCMMHEYIKDRENKKLEDLVRNGAHVNFMVDGKTPLARAIMLKNLEAFRILVSSGVASIGHDPINENGDKPLHLAAAYGFIDVIDNIINAGGSVNAPNKRKRTPLHSAVAAGHFEVASLLIRRGAEVKDQETMTVPLLHMAAASHNIEVVQMMLERGVETNLRDHQRNTPLHIVASQAKIYLNQRMVLPALYKSKLEKNLDMVLMRVSNRTARPTIPGKEKYRDVARLLLEHGAYVRACNSDSLTPLDVVERGDDPIPELLSMGACVNQQDAQGVTPLGACCWEDFHETAEELIQHDANINTPDLHGETPLYHACFHTSINCVRVLIEKGCDVNIANNCGETPLMAALPPIFYSDRIGIEANISCILEICQKVINAGCNLDAQDSRGRTALHCAVVRGHVSGLCLLAEHGCNLEICDEDRQTPFQKALLDKRPLFEVARFLVYYGANCRQEINVCRHDRIEMKSPLALTIEAAPLGGPRGKLRERYLLLRVLMEATYPYLGGLSTNLVLPQVSNIPHLVDPYRAVERETENWMRSEVPASLKFQARLKLREMLGVRNTLSKIDSLPIGKYLKSYLMLDLEKELPLSRSCMLHEYIKDRENKKLGDLVRNGAHVNFMVDGKTPLAAAVILKNLEAFRILVSSGVASIGHDPINENGDEPLHLAAIYGFIDVIDDIISAGGSVNAPNKRKRTPLHYAVTTGHFEVASLLIRRGAEVKGQETLRFPLLHRAAASHNIEVVKMMLEGGVAANLRDYEGNTPLHIVASQANIYLEQRMVLPALYNSKLERHLDMVIMAVSNHAARPTIPGKEKYRDVARLLLEHGADVKAYNSDSFTPLDEAEIGGDPVLIDIIKNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXQ9</accession>
    <name>A0ABM1VXQ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinetochore-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827202.1">
        <property type="nucleotide sequence ID" value="XM_035971309.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861601"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055404">
        <property type="entry name" value="ARM_KNTC1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24516">
        <property type="entry name" value="ARM_KNTC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="3">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 second ARM-repeats" evidence="2">
        <location>
            <begin position="277"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827202.1"/>
        </source>
    </evidence>
    <sequence length="824" mass="92626" checksum="1D109A4A71968482" modified="2025-10-08" version="1">MDSHAKDTLGEVLCLKLKSGDKNDPFQSQVKIELMQIQRRFKAYKLVLGKGDYRATDWEVFRDDDPYKLFCQFLLSDVGKAFSLWTSLEMELQRAYVPGMLCQLLANVPATVDLRLISDWLTQHVLAFVIGADPDAVNGVVDWTKEQVGRLELGNEDSWTEQALELCQAVLQGLQTLLKGGGSHMLPCGAHPRVQVKLDSRHVLSQLYTTIDLLKQLQELKSKFGFRLSLHSLSQETKAGVVHRMLDKVVAVDMLPATLREQVLPYVRHHGLDVDTIFAAYVEELIQTSAQPGLQCVGSDWETKAKAIVDVISGPVEKVKAAQGMLEHTPLPIPEAVVTVVTDVIATVRHPLVELLVEKWQMKEADNLLQRYGLPICPMSVAQVKEVAKYMVAQDQTSSWDDAHKFLTAHRVDMTLELAYFYTRVLVMRKQLEKVKTFVSSQSRSVGKKCLYFIVSLAEGMMEDMGERFMKALKEKRLLMYDAAIKLGPMLGDLEENALEREEALRQGARVKQARDLELEKVKTFVSSQSRSVGKKCLYFIVSLAEGMMEDMGERFMKALKEKRLLMYDAAIKLGPMLGDLEENALEREEALRQGARVKQARDLEIHFGICVGSRDVWGSKTAEQIFRKHIGDLSRTMLLSLSRLLELSRSQTVVEMLTAAAEQSTSEVYRKLFMKLVNVMTEYKKCPNIHMVDLAFDLMKSDKETVTLSLQLLKHVAVDCRLEILPEVLRFCSYLSVVENSLRVCQDHGDFEASFVDSLMADWGSDDFVEKSRNLRSEVVLTDVLEGFLSAVPGEGSMLSVSTLSEGDSSPGEESNCNSNTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VY43</accession>
    <name>A0ABM1VY43_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multidrug resistance-associated protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC118478243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035827336.1">
        <property type="nucleotide sequence ID" value="XM_035971443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478243"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="95"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035827336.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="36884" checksum="63E88CBB360FF8C9" modified="2025-10-08" version="1">WLRLRLEMLGSIVVLSAALFAILIGDVSGGTVGLAITYALQITGALNMIVLNGTLLESNFVSVERIVEYSNLPQEPDWILPHRRPQEGWPPSGRIEFDGYSTKYRPHLDLVLRNLTFKVEGGEKVGIVGRTGAGKSSLSMGLFRVLEAFQGRIIIDGVDISSLGLHDVRSSLTILPQDPVLFSGTLRMNLDPFMRHSDAEVWKALENAHLKVFVTSLPERLLHVCEEGGQNLSVGQRQLVCLARSLLRKTKVLVLDEATAAVDLETDSLVQKTIREAFQHCTVLTVAHRLNTVIDYDRILVLDKGEVLEFGTPDQLLSNKQGAFYSMAKESGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYW8</accession>
    <name>A0ABM1VYW8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase DDB_G0268948</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101864705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827611.1">
        <property type="nucleotide sequence ID" value="XM_035971718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864705"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035827611.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30000" checksum="EEDB13875B487434" modified="2025-10-08" version="1">MSGLKLTEHYAIKDVADAYDQRLNFSQEVFDKIHDFCEANGSEFLLAVDVCCGPGNSTVIGFDVSEEQLAHAPKNLPNVQFQVANANDMSFLESNSVDLVTVAMALHWLDLERFYREVDRVLKPGGVLIIYNYSYYVRLSPPQAQKVHEHYSGLVLDRYYESYMDNVRDDYRRIALPYPGWKRNDDLNLEREFTLDGYLGYLNSISLYDRYSKEQNNTDFMADIYKAMEQALREAGMTSKDSLIKASWPLFMLMGQKPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZZ2</accession>
    <name>A0ABM1VZZ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827985.1">
        <property type="nucleotide sequence ID" value="XM_035972092.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478459"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF13">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047398720" evidence="1">
        <location>
            <begin position="17"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827985.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19570" checksum="9608B65ADA30345C" modified="2025-10-08" version="1">MNVLAVLCVFAPLVMSQQVSDPTKVCLPQRFSGVAINLVTELAANFSMDFGRQKVAAENGTIRHVIDLAKNQGYTFDAQGTCKRFTLGLSSTWRQCLPSSAVFKNQLKAGLGSVRFISDLYEIPFGAKASTRILVSKESSYSLPYLRRDTFNGQLVLTLFANHKLGVSDPAIFNVPANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W279</accession>
    <name>A0ABM1W279_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101861164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828772.1">
        <property type="nucleotide sequence ID" value="XM_035972879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861164"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046650279" evidence="2">
        <location>
            <begin position="20"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828772.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="58647" checksum="069B482283DAACDC" modified="2025-10-08" version="1">MVPKLYVLVLVITIGGGLSQTADTDYATQHESSPHKETSLKENLIALQADSDDPTDGNQSNNTALFEQILMTVPETCQNRFHLCGSLNPASKTLIEQGQFCTVLSNPLAKLCLVSMGPCTDEDFKSVKTQSCSEEHNFPSPTQQTQAPTQQTQAPTQQTQAPTQQTQAPTQQTQAPTQHIQSVNQNNTALFEQILKTVPETCQNRFHLCGSLNPASKTLIEQGQFCTVLSNPLAKLCLVGKDFCTDEDFQSVKTQSCPKENVPSPPTQQPHTSTQQTQAPTQLTQSPSQNNTALFEQILKTVPETCQNKFHSCGSLNPSSKTLIEQGQFCTVLSNPLAKLCLVSMGPCTDEDFKSVKTQSCSEEHNSPSPTQQTQAPTQQTQAPTRQTQAPTQQTQAPTQQTQAPTQHIQSVNQNNTALFEQILKTVPETCQNRFHLCGSLNPASKTLIEQGQFCTVLSNPLAKLCLVGKDFCTDEDFQSVKTQSCPKENVPSPPTQQPHTSTQQTQAPTQLTQSPSQNNTAPVLYSTVKSLGKIVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3C7</accession>
    <name>A0ABM1W3C7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101850052</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101850052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829170.1">
        <property type="nucleotide sequence ID" value="XM_035973277.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850052"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035829170.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18764" checksum="2CBA5E13AA1A6004" modified="2025-10-08" version="1">MVLKNATTHKAVSKHVHANNSLNVCSGFSRRVCPRLFERARDLWRQGERSTLLTQVAPSARPPRLTMSESITVLICLLLAGLRATNGHTKPSLDLTLLATFTRLPVHLPASAYLNIRCNYTGLSTLSFLGIGKRPDCCSTTENLAFITPEDRGETHHRTKVRHPIRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W469</accession>
    <name>A0ABM1W469_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC118479020</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC118479020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035829462.1">
        <property type="nucleotide sequence ID" value="XM_035973569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118479020"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF117">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035829462.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="69271" checksum="9E56FC3E37182774" modified="2025-10-08" version="1">MQSLARRPRIWLKIALAWILSLLFPIPQLFIFVQYTHGTKEDGTPRRVCGSNGYTSPWQRKVYYTFNMTYILVVPMIIMLYCYAHIVKVVWLRARNESSSLMAAPPPPMPSMSAGKSARKESSSPCSKQGRNHSSSSSSSESKTGRNSSVESKNSASNSCKMAASTSGTIVVTPNVVVTSDEQGGAGSPAKRKLASALSGQGQGHSRSGSTNSVHWARNVSSPDTDDACSDHREKERSPSAASTNRERERLAPDTLVKPQEKSQHLSAYPASPRMSVRRGLVTASKRRALVMTLTVVLSFLLCHTPYFFVNLVRIFSDYKIKIETLKTMSEFLVMVHSTLNPLLYGLFTLRQYHLFALLAFFKCIKPRQSSSKSKSKSRRRHFGEERHGLLSSVRSKLSRNGKVKTNFSSSSSSVSSRTKRASSGGVSGSSNQNFKHSLRARHGPTKLFPRSSKAATTTTAAAATSLSAPTSSPLPSPGAPPTTNNTSSPSPSSFSSSSFSFLNKFRRSPLSQLTGRGKKPKSKSKQSHETLLFANTGAIRMTGSVVAKPDDTECSELETSPLGSREFPPATCYGNHSVHNSPHSDLTVEADGLSRAPNLGSDVICACPKVSEYSDAIDTWTSPEEGEYMIGGLTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W474</accession>
    <name>A0ABM1W474_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LOW QUALITY PROTEIN: protein ALP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC118479023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829467.1">
        <property type="nucleotide sequence ID" value="XM_035973574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118479023"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="171"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035829467.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44024" checksum="FC39884F150CEE28" modified="2025-10-08" version="1">MDSSSDDEFFLLDSLFPKLRTARHGRSTNVHDINKERPHLGEYHHLFKQLKSYPDRFYSYTRMSIETFRYVLDKIEHRLIKTWCNWHRPILPEERLVVTLRYLATGSSFQALAFSFRMGASTVAAIVSETVGILWDELHTQHMPVPAVETFKTIATDFFDIWNFPHCVGAVDGKHIRVKCPANTGSXFFNYKKYYSVVLQAAVDAQYRFIAVDVGGYGKQSDGGTFQASGLYQALMNNTLNLPEPAPLPQSNVVAPYVFVADEAYPLLPFLMKPYSGGNLPLDQECFNNRLSRCRKVVECSFGILNSKWCILSKCIDTGVNLADKIIKCVCILHNTIIDREGMVQNLTDVSFPRSGVAWELAGRPTNNAKGVRDIYTTYFANNPLVYN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1986-07-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>P01361</accession>
    <name>ELHL_APLCA</name>
    <protein>
        <recommendedName>
            <fullName>Atrial gland peptide B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>ELH-1L</fullName>
        </alternativeName>
    </protein>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1983" name="Cell" volume="32" first="7" last="22">
            <title>A single gene encodes multiple neuropeptides mediating a stereotyped behavior.</title>
            <authorList>
                <person name="Scheller R.H."/>
                <person name="Jackson J.F."/>
                <person name="McAllister L.B."/>
                <person name="Rothman B.S."/>
                <person name="Mayeri E."/>
                <person name="Axel R."/>
            </authorList>
            <dbReference type="PubMed" id="6687446"/>
            <dbReference type="DOI" id="10.1016/0092-8674(83)90492-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1980" name="Proc. Natl. Acad. Sci. U.S.A." volume="77" first="2328" last="2332">
            <title>Purification and primary structure of two neuroactive peptides that cause bag cell afterdischarge and egg-laying in Aplysia.</title>
            <authorList>
                <person name="Heller E."/>
                <person name="Kaczmarek L.K."/>
                <person name="Hunkapiller M.W."/>
                <person name="Hood L.E."/>
                <person name="Strumwasser F."/>
            </authorList>
            <dbReference type="PubMed" id="6929554"/>
            <dbReference type="DOI" id="10.1073/pnas.77.4.2328"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 36-69</scope>
        <scope>AMIDATION AT ILE-69</scope>
        <source>
            <tissue>Bag cell</tissue>
        </source>
    </reference>
    <comment type="function">
        <text>The atrial gland peptide A and peptide B precursors are the source of the 2 peptides that, upon release from this reproductive system gland, initiate the egg-laying process by exciting the bag cell neurons. These neurons, clustered in neural connectives near the abdominal ganglion, in turn release other peptides that act directly on the ganglion and also, via the circulating hemolymph, on many other organs to control the physiological processes of egg-laying. One of these other peptides is the egg-laying hormone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the molluscan ELH family.</text>
    </comment>
    <dbReference type="EMBL" id="J01018">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A01631">
        <property type="entry name" value="GOGABA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P01361"/>
    <dbReference type="EnsemblMetazoa" id="XM_013089688.2">
        <property type="protein sequence ID" value="XP_012945142.1"/>
        <property type="gene ID" value="LOC101852132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003424">
        <property type="entry name" value="ELH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02323">
        <property type="entry name" value="ELH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0027">Amidation</keyword>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0527">Neuropeptide</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000001810">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001811" description="Atrial gland peptide B">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000001812">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="modified residue" description="Isoleucine amide" evidence="3">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="6929554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="122" mass="13619" checksum="41E23272E67959FE" modified="1986-07-21" version="1" precursor="true">MKANTMFIILCLTLSTLCVSSQFTSVLGKIFVTNRAVKSSSYEKYPFDLSKEDGAQPYFMTPRLRFYPIGKRAAGGMEQSEGQNPETKSHSWRERSVLTPSLLSLGESLESGISKRISINQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A161R9R0</accession>
    <name>A0A161R9R0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NdWFamide 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101845620</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845620</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>Identification of neuropeptides in Aplysia californica.</title>
            <authorList>
                <person name="Kohn A.B."/>
                <person name="Citarella M."/>
                <person name="Moroz L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="GU973880">
        <property type="protein sequence ID" value="ADX20594.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005097583.1">
        <property type="nucleotide sequence ID" value="XM_005097526.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A161R9R0"/>
    <dbReference type="GeneID" id="101845620"/>
    <dbReference type="OrthoDB" id="6159804at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007825732" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADX20594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097583.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9844" checksum="C3847E1404F8DD03" modified="2016-07-06" version="1">MSRALAAVTVVFLLSVVCSPTSANWFGKRGDKDDLFSLLLQQQQQQPTHADSSIVPLASTGAEDAMFAIENIVQAWRQHRSEKLGRSTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA15</accession>
    <name>A0ABM0JA15_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859745</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005088891.1">
        <property type="nucleotide sequence ID" value="XM_005088834.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859745"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046253615" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005088891.1"/>
        </source>
    </evidence>
    <sequence length="1039" mass="117096" checksum="1C00D759EA5BECD5" modified="2025-10-08" version="1">MTGAIGIVCVLAILTAQAISSPVTPSVCINALAPPTDLPGVNQMGNDPTTPLFRLHFTKHTENKGRRDSRQAYRVHLAVTSSRVAFSDAKVSLETTGNCGVGSLKYDSNDFFQARQTNDSCPKLLLTSHKTPMTELPSLIWTPPECGCVLVRVLVIEKGTVYYAEREGVKKGPLAQLVCVKKASREQYLDTLCSVLDRYLTTEIISSDSFLTRHRLTERTADRFSLDLNIKMRRSDARTCCSKDSSEERIECFNDSRWHRIDRFCKDGSPDLPLTELRMVHMRNREQECCFIFGKYRYPCFAEGNKAGRAFVGASPLDFSMDETDPANDVAEFVSEKDQDIVSKLTPLKFDVGVNEDPVETRKGVEQLPKDKFEKSNAKDTDNEVRNSNTKTGAVKRERKRKHHKATETGDVAPSLEIQGVHTTGTPSEVARLPPRSDHSFPGLVTDRSRGAPSKPRRKMVPGERFHDATNFPDDETDILARTLTNVDRRLGLRKSGETKSGRRSSGEGFGYRQNSGDIENYDGLLSSGIYDKARNGAPAKRLYPEAEGGASWMTRFSEYPKGRVLAAARHVSRGLNKRLSNADRRRKSSKVQHGIEDQGRASVDKTLGKLERKLQRLRLKQHCCEAGAAAGGQVYGGFTHAWRECSHSSEKLVDRLRPTFGHKVCREQFKKCCVEMSVSGPSMTSQEFREAEFQYLDNRQRIPASQMADHGFDGVGRETPEEYDDAGEKRYKSMREVPDDEDFFDEEYNGPARFDEIDDEMAAEYGGLDRSGVEKKDEETKKKALKSKRRKDTKNDDDVDDDDDVEDEDEDEKFELELGLVDVGALEGQVVPKKEVLRKNDKNTTETSQKEFKKGGQTPQNSTTQTAAEKEERREAVEVRPKHHRKSKEETENKEAAMSGFDAQVLDIIGRPTQPRAPSRSQNTPKQRRRRKHHGGSSKRGRSRSRSKEGRRRSSRRSSRKSKERRHRGGRHRYGHKTPQYHHPFGPGGAKDSHEMAAINTRRMAGGMDSKELAEAFSQGTFAHPMRDRTPSRSRSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBR1</accession>
    <name>A0ABM0JBR1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cleavage stimulation factor subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101863859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090007.1">
        <property type="nucleotide sequence ID" value="XM_005089950.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863859"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005090007.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="41563" checksum="31CF4E1D22016927" modified="2025-10-08" version="1">MAAFAANFMPQDPNNSLSSSNTATAADRAQRSVFVGNIPYDATEEQLREVFIQAGPVVSFRLVYDRETGKPKGYGFCEYQDVETAQSAMRNLNNYDFNGRPLRVGVAAGEQNKDDGKSMQQALGGQIVESPYGEPVEPEKAPEAISKAVASLPPEQMFELMKQMKLCIQNNPNEARNMLLQNPQLAYALLQAQIVMKIVDPQVAMSMLYRDESQPQINVPTGKLPQQGMGQRLPGGVGMPMGNMPRPIRPPQVNVPQMAMPPRPDMMMMRPAVPQGKGDMGEPRRFPQPNVQGSGPAPRMQPPTAPPGLPQPQRPPASQAASSSQPSSSSNPAANGAANISAQDQEKAALIMQVLQLTDDQIALLPPEQRQSILILKEQIKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCN8</accession>
    <name>A0ABM0JCN8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC101849662</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6 7" type="primary">LOC101849662</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090634.2">
        <property type="nucleotide sequence ID" value="XM_005090577.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090635.2">
        <property type="nucleotide sequence ID" value="XM_005090578.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090638.2">
        <property type="nucleotide sequence ID" value="XM_005090581.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090640.2">
        <property type="nucleotide sequence ID" value="XM_005090583.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827752.1">
        <property type="nucleotide sequence ID" value="XM_035971859.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849662"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039684">
        <property type="entry name" value="FANCG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15254:SF2">
        <property type="entry name" value="FANCONI ANEMIA GROUP G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15254">
        <property type="entry name" value="FANCONI ANEMIA GROUP G PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090634.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090635.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005090638.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005090640.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827752.1"/>
        </source>
    </evidence>
    <sequence length="795" mass="88436" checksum="79DD3C3A622BBDE9" modified="2025-10-08" version="1">MEENNTSQTGFLHSCVVTADVIVDDFLQTNLNVEGNEARSKVFKEKLRKILLWTSVHPPSQNVSFLELTVMANYTMLCTAARLRLAQRSPETGSTSQLFTLMCSTLNRVLQLSGQSGPAPGASRIVAVEEEIMRLVSLVDSPLCHFKLLPVLGRLLLLVSVWCLYRQLDSSGSGLSLSAKALDVLLKLRKSVDESVLKEPVSQKRGLYLCCRPTCPDGEVDGSSPCVRDVVDLVLTACGASPPDAAVNFDEWNWLFCVFECERLINEQQPMLAIDKLQSSLSLPLDPEEKSRLLCLLAKCYLSQDYSQLTIQSFKAALEANHENLTVFLQLAGVYSRLKHHDLEIECLRILVKKVTNRELKSCDTKHIIKDFSCTVAEISGAVSDVTFVQAVHHFGKRCFQLQRYKEAAEQYLNLLNHLQDPDKVNKDPCDRELNVKVFIVETVEAVAMAQRHEECIALCEEFIPCLLDGEVSFKDSPKVGRHFGLFSQCPTEIVGRKEQSTQDYLCSSPCFLGESSRRDDVVNNVRMSSLSKDFSVGTGRGSNPLFTPGSLRKLLKNPRKRRRSSSDNGDLFVMETDSGEKKESGPSDYLAVRLLVCKTDCLVGLHGYTEDAMTCLLRAHNLLLDSAPGNVVQDPPLPGPSSKRQKASLEEHNMPDHVMGSATGDGSVRDSYTQLMIEVALRMGKMSLKRKLLPSVLRSCHLVLQLDPGCVPAHYLKTLVLKERKGQEMGAATDWLRLRGIDMDAVEAAISHKQAKLGQVESELEKQNVPWWTTSDVHLLSLDLLCLQMLPLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGU8</accession>
    <name>A0ABM0JGU8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein zwilch</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101848807</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the RZZ complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Chromosome</location>
            <location evidence="1 9">Centromere</location>
            <location evidence="1 9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ZWILCH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093363.1">
        <property type="nucleotide sequence ID" value="XM_005093306.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848807"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018630">
        <property type="entry name" value="Zwilch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995:SF1">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09817">
        <property type="entry name" value="Zwilch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093363.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="69945" checksum="F1797D806E66E683" modified="2025-10-08" version="1">MSEAVKKGLKSFDDFLLDYDVFKSDTSTRNVTAVCNLDYAAASLAATVRLLLSKDLANKTFLLVFGKKSSENLDDAVADTADTSSSSGTTFQQDSQVQDPTSPNSTNFIGQQSRSRSMFGSPLKLEAIANLSGSDNRAVTSTPVEKAKRVVFLPPVPADKAKKILSAFAKNNLSASGTQLVTVFCFDKDQPKKPLLYGMYRGNNMHGEIELRTFKVTAKMNDSKVNLASVEPMLISCGHDCQMAASYNILEDKDGMGFMTLEAKWSDPNGKLKLSRLPQTGFSLDMSIQSGNEYSPVFGYFCELQKVKRFMSALKKEEMPEMLSAATASVSNTLKELLQNLKLGVSPPVVTGSAEVRSSSHMARQLNLEQRQNKDFTDFLWEVLSQCTDLEGLSSCLSATFAALKAGDLPTFVHKDNQTTIAQLVRQSHSGIAYFPSLTGFLPVRLVTEIGVHKIYKDYMALFLGNRLCTAGQWEEFVKSQVEGTVGIVDMEEIYQKELSQKFHVLTKLHHCLEVVSIVDIFTEKQTLSKITKSLLDLYKSEDLNEEKVFSYPITVVQAVPEIKKVRPSMMKREASERGNTYIDCFLSELPSSLSGFASAETVVSPGDVSSILGDCEDYYLFQTTEKCLTLGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGY8</accession>
    <name>A0ABM0JGY8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MAM and LDL-receptor class A domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101852008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093462.2">
        <property type="nucleotide sequence ID" value="XM_005093405.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852008"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046765017" evidence="5">
        <location>
            <begin position="24"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="80"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="6">
        <location>
            <begin position="138"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="557"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005093462.2"/>
        </source>
    </evidence>
    <sequence length="658" mass="71520" checksum="38933EED1DD7F00F" modified="2025-10-08" version="1">MNLLRVLDVLLVFAFLDLASVFSNRCPSVTLKNGRARYRTRRKMIHYRCNRYFSRVGPKFAVCLPSNQWSQKPPVCVNGRGCPALPDDPQLTMVKKFRGGLVRFSCGSGLRRSGAEEIYCDGTSWNLPPPTCIEGMSYGCDFENSDNCGWNHDATDEFDWARTSGGTPTANTGPQADHTTNSSTGHYLFVESSAPQEAGHKARLVSPPYNGDKVTGLCLEFYYHMFGPDAFGEVGELDVYVKPQATPTRALTSDHNIFHREGNQGDQWHRADVDIPDQTGFFEIIFQGTRLRGWLSDIAIDDIRIFNCSDRVETTTVTIPTTTTSSATPTEDVDDFTYVHTPKSSSATITPTTPTTTTTTTPTTTATTRLTSKTQSPTTTTSTTTPTTTSTTSTTAVTATTPTTTPTTTPTTTPTTTPTTTPTTTASTTTTIATEASTTTTRSTTRERRTRKPRRTTTTTTTASTTPKVTEKYAGSTDMTKDDTTNATVVAERVTSSQSQNRSRTDDEDDTATTMMNSEDVTDSGTQTAGSHTKDFFEYTADGTTTSVFSDVSASATTEKVDDTDINGNNDTDNDTDSTKNENTRKEGRVKGGSGSSSGMGELLPLIVGVVAAVIVGAIVIAVLAWMWAKNQRRKQEKEQEDEMNIITEYVDTSLSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH30</accession>
    <name>A0ABM0JH30_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neuropeptide CCHamide-1 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101845677</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093521.2">
        <property type="nucleotide sequence ID" value="XM_005093464.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845677"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001556">
        <property type="entry name" value="Bombsn_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF26">
        <property type="entry name" value="NEUROPEPTIDE CCHAMIDE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00358">
        <property type="entry name" value="BOMBESINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="109"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005093521.2"/>
        </source>
    </evidence>
    <sequence length="433" mass="48004" checksum="FF13300DCF43F2D1" modified="2025-10-08" version="1">MTLTIDLSSSSTLSPVATPPAEQATAAAVVAASLSSLSQLSARLPYTSGTMSHPNNSTNVFGTTSANATEVSNDTEIDYTFDRWGINSDLDGILVPIVFGIIFVVGLVGNGTLIISVVANKVMRNVPNILIVSLSVGDFLLILISVPVASTLYTFINWPYGWVVCKANHFLQTVSLGVSVFTLTALSADRYVAIVDPMAKLAGRTQRTTIAVAVAIWVVSIVLAIPDAVFSTVVSNKVEHLKTIVVSCAEYPPEMSSIYPRVFTLIHLFIFFILPILTISFFYAMMARILIRSSDSVPTESKTGAANHQRQIAARKKVAHVVLSFVIIFIVCWLPRYVYVMWFHFDPSDYSLFWHTFKITAFCLKFINSCVNPFALYFLSGQFRKFYNRYLFCCCRRVRYTSLEPTSTMHHLHSTTRRSSPTNMSMVHSQSMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIC1</accession>
    <name>A0ABM0JIC1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Charged multivesicular body protein 7 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094299.1">
        <property type="nucleotide sequence ID" value="XM_005094242.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860395"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057471">
        <property type="entry name" value="CHMP7_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25239">
        <property type="entry name" value="WHD_CHMP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25880">
        <property type="entry name" value="WHD_CHMP7_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHMP7 winged helix" evidence="5">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005094299.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="51237" checksum="CA87919D34E39A2F" modified="2025-10-08" version="1">MASSDGPRTHQQASDKGARDHVLCQTSALNLPVELQDDQQAAVLYSPFRDKSVNPRSWSRKMEFWAALLLSTALERDIISFDSNTLPALFERKGMTPKCLKTVIEELKRSGKLQFLEDYNRTEGWLSWGLNSLVKQPLSWGVSRILGSANKNSNIYVWPEVVQKVSDKLVDFHHRNMQHEVTDCVTTLAAFRGECLPLVPQDEDFNIVLQNLKKSGRVQIKDLEDGTVVVKLCKRGQSTAEPFKDTDIQIYRITVTQKKLEEEAELLSSRIDGFTEEARSYVQQGRKTLALYSLRKKKATQKVLDRKSACIMKLQDIVIKIEEARTNAMVITACETGVAALKSLEKDLNIDRVEAVMDEVGEALEDQEEISSAMEAAFPAHQRDLEEDLEQELQELLSGNRDEIVDISLPHDDSLSLKLSSLCVDDMDLPNVPTHSPSGSAASRKNSPSSVKTALYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ72</accession>
    <name>A0ABM0JJ72_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Cytochrome P450 4F22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101848649</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094867.1">
        <property type="nucleotide sequence ID" value="XM_005094810.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094868.1">
        <property type="nucleotide sequence ID" value="XM_005094811.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848649"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20659">
        <property type="entry name" value="CYP4B_4F-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094868.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="57671" checksum="E78DC9CD8096006D" modified="2025-10-08" version="1">MWLETVIAVVVGAILWRYLRQYAEYRRQYFILPGHDRYSYLYGSIKLYPGFNEEGLAFDMDTLKRHKYLCHWWAGPVTPVVSVYHPDSVHPVLKSSAPKPRSSFLVSFYDMGLPWLGEGLILSNGSKWAKSRRLLTPAFHFDILKPYMAVYNSCANTMLTKMEAFSVKEEAFELFDLIDKLALDVILQCAFSYQSDCQTSSDSSYTAAIVELVTLWGERTLSPLHFNDTLYKWSAKGKRFYELCKLTHQMSEQIIAKRIETLENADETELQKIVSKKTKDFLDILLLTRTDDKDALSPVEIRNEVDTFLFAGHDTTASGISWTLYSLTGHPEYQEKVYQEVKDVMGDRDTVQWTDLASLEFTTMCIKEAMRMYSTVPSIIRTLEEQLVIHGHRIPKGSMVAIQLWMLHHNPHVWEEPLTFDPNRFHPDKQCLMDPFQFLPFSAGARNCIGQNFALNEMKVTVAKTIKRFRLSLDPSHEVRQVPLITMKPENGLMIQASPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ88</accession>
    <name>A0ABM0JJ88_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101855936</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094899.2">
        <property type="nucleotide sequence ID" value="XM_005094842.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855936"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF17">
        <property type="entry name" value="IRF TRYPTOPHAN PENTAD REPEAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="2">
        <location>
            <begin position="87"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094899.2"/>
        </source>
    </evidence>
    <sequence length="651" mass="70503" checksum="155968FE9564455F" modified="2025-10-08" version="1">MCVPNESRFSSSSPGTPRRWKALQSLGWTPSSLGARHCTCLVGPHRMTKSPRRHNRRSVRAAAPPVLSFRCSSNMSSSNLQDRPIPKQRLRPWLERLLNNHGSCPGVEWVNRKEQVFQIAWRHASSQGFQENKHSDIFKRWAQNTGKRIDHTKNKSNFRCALRSLKDCVELTACGDKRGEGARRTYQFIDESHPDYDKKRRKQSTARIKQEVVRPVRDDAPVTRSRKRKRGAEASSDATDNSHVQDIHEALNEAPESKLDPGTVAAEGHPSEKLVVHNVPESGNLLVAASPEMERFLSICPDAVVVDVESNQGSGQACGSSGEACSQASGSSGQVCVQGAGFGDQASGSSDQAFGSTDQAFGPSGQTFGSTGQASGSSGQAFGSSGQASGSDGQACGQAALSSDQVLYSNGAYTSDMYTAKRSEDGTLCITLTTSLVTKAEGSEDGKYMKDLEENHRSVGCSVQSPEGSSKLPNFKVLGFPEYQSVGSYTCQNLTSGGQVRVLGPDVKIPPITEIILPYHTTSPVQTEQGTSQELTRGPLHELSEVVHEVGPQDDASSFIRFLDLLQSKGSSEYSAENNKAITQSCAESQPELAMTMTHFPATEALTEASNVLLYDDPMMPNGKTVLVEFVEQMSLPLFVDPDDIFTVKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJT5</accession>
    <name>A0ABM0JJT5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101856170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095330.1">
        <property type="nucleotide sequence ID" value="XM_005095273.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856170"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005095330.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38661" checksum="857FC59FD321622E" modified="2025-10-08" version="1">MAASVKNKKCLVIGGCGFLGRHLCEGLLERGWTVNVFDIRSTFEDSRIKFFIGDLCKKEDLLPALEGVYCVFHCASPAPLSNNKALFYKVNYEGTRNVIEACKEAGVKRMVLTSSASVVYEGKGIRNGREEELPYAAKPLDYYTETKILQERTSLEANSDDFYTVAIRPHGIFGPRDLQLVPITVDMARKGKTKFIIGDGKNVVDFTYVGNVVHGHILAAEHIGPGSPANGKAYHITNDEPIFFWTFMTRLLTGLGYPAPRIHLPYSLLYVVALFLQFVAWIVSPLVIFTPSLSPMKVALAGTDHFYNCENAKRDLGYSPVFTLDQALKLTIESYPEMRNPEEKKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLJ0</accession>
    <name>A0ABM0JLJ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuroblastoma suppressor of tumorigenicity 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096533.3">
        <property type="nucleotide sequence ID" value="XM_005096476.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859165"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF4">
        <property type="entry name" value="BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CTCK" evidence="6">
        <location>
            <begin position="32"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005096533.3"/>
        </source>
    </evidence>
    <sequence length="135" mass="15344" checksum="5587673E8F525F8A" modified="2025-10-08" version="1">MKAQNVVKKNEGSSLVNAIISESPVSSSSSTCRHRIETTLIAVPGCVPKSLLITRCQGSCHSRSVPEFDTDRQEVRHVEHCSCCKPMVMKFRAVRFTCPRRRQRFFVKRFGFPFRCACRPCANVPEVTAEQPYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMB5</accession>
    <name>A0ABM0JMB5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM98A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097040.2">
        <property type="nucleotide sequence ID" value="XM_005096983.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861035"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF1">
        <property type="entry name" value="PROTEIN FAM98B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097040.2"/>
        </source>
    </evidence>
    <sequence length="416" mass="44112" checksum="225D912DBE2CB107" modified="2025-10-08" version="1">MENDILDSLEDLGYSGPLLDGSALNEAAEAGAKSVAYTELVEWIVSQLAAFCGIDEKVSAIQGPGDGDNFLMELSGFLREFSCPYSTLTQGPIEGRLATKESCLQLLDYLLTELASVKMIASKKPAVLASLSKTPTEVAEPSESEVAKSLREMLMALKFSKPPPNITGFQLFSKIESKVKEFMSKYPNQIGKPLLKTRLSDKQWTHILAINDILSDEYRVRREMLLKRLDVTIQSFKWSDKAKSNDNKIAGVYQPIRRLLVSKTNVGVPQILAARDDLTRLQKTSSGEARERSKCAINKVLIGRVPDRGGRAWELEPPPPEMPAFMKRDASSGGRGGGGFRGGGRGGYQGGGGGGGYQGGGGGGYQGGGGGGRGGGGGGYQGGGGRGGRGGGGGRVQGGWGDSQQQTQNVGGNWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMD4</accession>
    <name>A0ABM0JMD4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Lariat debranching enzyme B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101852762</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097087.1">
        <property type="nucleotide sequence ID" value="XM_005097030.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852762"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="235"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="399"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="594"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005097087.1"/>
        </source>
    </evidence>
    <sequence length="665" mass="72169" checksum="01B7E4DFAE7AB52B" modified="2025-10-08" version="1">MKIAVEGCCHGELDAIYETLASLEKENNFKIDLLLVCGDFQSVRNYSDLEAMAVPPKYQQLQTFYKYYSGEKKAPVLTIFIGGNHEASNYLQELSYGGWVAPNIYYLGYAGVVQVGGVRIGGVSGIYKSHDFYKGHFERPPYSNDTKRSVYHVRNLEVFRLKQLIRPLDIFMSHDWPQGIYYHGDTDNLIRMKPFFKKEIEDDTLGSRPLGELLTHLKPTYWFAAHLHVKFAAHVLHQQTDPSTPAKTTKFLALDKCLPRRGFLQVLDVPHKESEGLKIKLDPEWLTVLRTTNHLLKLTPTNTYMPGPGGAERYNFEADDKDLKETVDLFGGDLTLPEKGFVTTTPPLVGTPNPRSGRTPLKVVVNPQTSLLCTMLDLTDPMASFLGKSSEELLEKSFGPISAFGGGSDEMDDDNDDDEANESSAEMPSYIDSSMEVSSTSFSNVSEVAKETPQLSKSQSLSSVLPPPRAVQPSDVRVDDDDEEFLSILSAQKKASPVKALSAPAYVSSSTSGDTDMKMATALSHQRSTGDSANSTSPESSTTASGLGLSSAQQLPSTDRDSGVCSHSSPTASLSSSSDAVPSLGQKASSFGMSSLRLDSTDSSSNLSSHSGVSSSPSTPSPANRKRDSGEGEITGSAVTSSPVVSGSASKRLKRRNISAYADPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JME4</accession>
    <name>A0ABM0JME4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General transcription factor IIE subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101855866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097103.1">
        <property type="nucleotide sequence ID" value="XM_005097046.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855866"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021600">
        <property type="entry name" value="TFIIE_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11521">
        <property type="entry name" value="TFIIE-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005097103.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45751" checksum="DFE6B2A3DBBD57FF" modified="2025-10-08" version="1">MDSEVLLTVVPEDLKRLVRLIVRGFYTMEHAVVIDMLVRHPCVKEDDLGELIKYDKKHLRSILNMLKIDKFLKSRMRVETDAEGRTTRHTYYFINYSVFVNVVKYKLDHMRRKIETDERDNTTRSSFKCPGCEKTYTDYEVGQLLDPSTGELICTFCRSIVEEDESSIPKQDARTMLARFNEQIQPIYELLKVCEDVRLAPEVLDPEPTDIKKIINRNNAGVSGKMSSDADRATWSGDATRNVGFGFSENRVTITMDDENAGKVEKKAQPVWMTQSTIEGVAAPLETAAMEASKLAEADKKSKPMGNDDILQTLLAHEQKAGPSRIPAPESSDGDSDVDEMKNGEDVEEMESDEDEDQGPMVMIGSQRVPYHSVTSDLVASMTPLEKEEYIRMGQQLYENMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMW7</accession>
    <name>A0ABM0JMW7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Legumain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097425.2">
        <property type="nucleotide sequence ID" value="XM_005097368.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850885"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045546461" evidence="2">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097425.2"/>
        </source>
    </evidence>
    <sequence length="437" mass="48639" checksum="2ABE33E6F41299C2" modified="2025-10-08" version="1">MRVLLCLSLLLAVSTLGVSARKNWALLIAGSASYMNYRHQADICHAYQIMHKAGIPDEQIVVMMYDDIANNTQNPFPGNIINKPNGPNVYPGTLKDYTGSDVNAKTFLAVLQGDKAEVKRLTGREGKVIDSGPDDYVFVNFADHGGPGILGMPEPPYLKATDVNKALKSMYAKKRFAKLNFYVEACESGSIFSGLLPGDINVYATTAANTHESSWGCYWDDSRSAYLGDTYSVKWMEDTDVANLNTETFEQQYKTVKKETTRSHVQQYGDTSIASFVLAKFFGNNKQLISNSTKPTRAVDQVPSEMVSLQTLKNRIQAAPANSQLKSRLEGELVKLQTTMTQTHDLIWDIVRTVYSEVPEKTAYDRVMKTHEDIKSFDCYYSVVDTLLGFCPGLDVTKNDFALRKFYALVNLCNHNEVGRIISAAETAAVINPLCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNX3</accession>
    <name>A0ABM0JNX3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RISC-loading complex subunit tarbp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101846211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098097.1">
        <property type="nucleotide sequence ID" value="XM_005098040.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846211"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19864">
        <property type="entry name" value="DSRM_PRKRA-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032478">
        <property type="entry name" value="Staufen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF3">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16482">
        <property type="entry name" value="Staufen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="105"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="251"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005098097.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35280" checksum="5F95119A02D8A8CA" modified="2025-10-08" version="1">MAVPPGKTPISFLQEYATKNAITPQYDLIANEGAVHEPTFIMRVSVGDRAVANGKGSSKKKAKHAAAQSALNILMGVSNGQEEAVKDEPNTPAAPAQSKDDEVGNPIGELQEFTQKKLLKPPIYEFVTEQGPPHAREFICNIKLGKFVDKGTGRSKKTAKRTAAARMLEQLRALTQDKESEKQLDDSDEDEEIPLGFDSKTSYSSLKQSKGNKNPVSPQSALEIQRFYEKVMIAGGKQVRGQGQSLTPPTNYCQMLQEIAEVQRFEVQYFDIKDDSTLGMNQCLVQLSTVPVAVCQGTGPIMDEAHANAAHNALQYLRIMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP83</accession>
    <name>A0ABM0JP83_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855020</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098311.2">
        <property type="nucleotide sequence ID" value="XM_005098254.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855020"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098311.2"/>
        </source>
    </evidence>
    <sequence length="353" mass="40395" checksum="7D5E87AEF67A4A19" modified="2025-10-08" version="1">MTSFQGLGLTRLMLEDLRSHFLSLGVRVRREMMVTKGTELAASKPSFSEEYKERLTRDILCYDMDSHDQEQYLHHCEGDLSQSLQCHVLDAARLEEMSKVLHMSTKPTERQLVVNWTPLCLQPENIPKLCPSNGYSLISFAFSERESASMFESFANINDSHSFTQGKTTQTTDIQRPEEDSCHTEKQPIRFEIGAEQTESKSSHMMLRSSSIVGTSVAVETSENTNSSLAHRNFSARSDNDFRYQSHQAPALLSFGNFFQCRLGLAYNLDLHLLNLSDRSYYIRQEELTHHLLLHVRKAFEVSAGVGGIHFLMFLDCNPGLQRCVKEIMEGKFRLRRGVWSSAQQHLYIKKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPK5</accession>
    <name>A0ABM0JPK5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein wntless homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101853163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wntless family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098548.1">
        <property type="nucleotide sequence ID" value="XM_005098491.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853163"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053936">
        <property type="entry name" value="WLS_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009551">
        <property type="entry name" value="Wntless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449:SF2">
        <property type="entry name" value="PROTEIN WNTLESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21883">
        <property type="entry name" value="WLS_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless GOLD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="10">
        <location>
            <begin position="236"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005098548.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="62622" checksum="C7EAC2EE8D080599" modified="2025-10-08" version="1">MAGVVLETLSNRKLLILSVSLVLILAVFFLIGGLVAPAPNSVIPSTTVKCVDADNIWQKGEMKPFLPRGKGKCDSIDHFSDPRVAREGIDANEIVFSQWMPLPKDGKQLDMSRWFQNMVSVIELDLTYNSQNKYPEDRDAHMVLETRVFYRNKEDDVKDWKLLAASTEHRTLQCSIENDNRQDGKRYQCDLLPFFELGTVFYDFYLINIRLPIDKRTDINIIGQLDDLAVVVIFQNGGFTKVWFSIKTVLFPAVVAVLLWFWQRVLTEGRATNLTERTLFSLGIILSIMNCPIEWLTLVVSMPFMTLLNDIRDGAFYAMLFSFWLIFVGEHMMDQVERNQLKAYWKQLTVVILASAACFIFDMCERGVQLTNPFFSIWSSEVGAIAALGFIIVAGISACLYFVFLCYLVFRVFRNISSKRTSLMQMSSVRRKYYSGLIYRFKFLMLVTLLCAALTVISFIIGQVSEGQWKWGDEDLSLEYTSAFLTGTYGMWNVYVISLLCLYAPSHKKYAADTVDETDTNSREEEVQLTQMASESSNIASFISKQAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQA3</accession>
    <name>A0ABM0JQA3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101860738</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005099019.1">
        <property type="nucleotide sequence ID" value="XM_005098962.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860738"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012234">
        <property type="entry name" value="Tyr_kinase_non-rcpt_SYK/ZAP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000604">
        <property type="entry name" value="TyrPK_SYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="4 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="36"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="187"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="405"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005099019.1"/>
        </source>
    </evidence>
    <sequence length="667" mass="76584" checksum="13AEE9BFC44BDFBD" modified="2025-10-08" version="1">MFKKASKLFSRTDKDKENSSKEVSEAEVLGVYIEPFFYGRITRQEAEDVLKVNGNADGLYLLRESFTPMGNFSLSISHNGEAIHYAILKQIDGKFQISDGVAFSDPVSLIEHYRSSKKGFLTVPKTPCLRIPPQEAIACRGLSYTELHSRMKTAAQKMNANIAKAFGPLREPLLVHVLKTIHKDMPWFHGEISRDEGNKRLEMDGHKDGKFLIRSRADGQSFALTMSHEFNLRHYCILVSDGETYSIENGNKFQALTILVDHYHNKRDGLPCKLEMPVPNPDTRHRVWKEYQQLSTDLTQKPGHKPDQPGSKKPLRPVPPIPLDDCFPVSPSTPTENGACFIAPGSSPSLERPPPHKCWEDEEELEDQDSTQFRSLTVEEAEEQEKIYSDIRLDVMNRGLNPDQVTLSENLGSGQFGEVKKGVCRLMGKDIRVAVKTLKNNDREAESEIMKEAELMKKLDHPHIVRMIGVCKSNSLMLVLELAELGPLKKYLERHKEMRTWHLLELATQICDGMRYLEQHDVVHRDLATRNVLLLTEHFAKISDFGMSRMVDSSEYYLAHVPGKWPLMWYAPECLYYHKFDTKSDVWSFGVTLWEIMSFGARPYAHKKPPQILAFLEEGHRMAKPKDCDDRIYNIMLSCWHFQKEKRPTFAELHPKLNKLFSDFQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQL8</accession>
    <name>A0ABM0JQL8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-iminobutanoate/2-iminopropanoate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099246.1">
        <property type="nucleotide sequence ID" value="XM_005099189.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854867"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099246.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15452" checksum="6491CCA2562D2FB9" modified="2025-10-08" version="1">MASPVSTRRAIYTSKSLKSPYLSQAIQVNNLLFVSGNLGWDMNRQGLVPGGAVPETEQLFKNLSAVLEAAGCSPRNVVKVNVYLKDMSDFAAVNEVYLRYFNQEPRPARTAVQVAKLPRGARVEMEATAVVGKIHDVTSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRY4</accession>
    <name>A0ABM0JRY4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heparan-sulfate 6-O-sulfotransferase</fullName>
            <ecNumber evidence="8">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101849466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56604"/>
            <dbReference type="Rhea" id="RHEA-COMP:9830"/>
            <dbReference type="Rhea" id="RHEA-COMP:14621"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:58388"/>
            <dbReference type="ChEBI" id="CHEBI:140604"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sulfotransferase 6 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005100156.1">
        <property type="nucleotide sequence ID" value="XM_005100099.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849466"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010635">
        <property type="entry name" value="Heparan_SO4-6-sulfoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812">
        <property type="entry name" value="HEPARAN SULFATE 6-O-SULFOTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812:SF0">
        <property type="entry name" value="HEPARAN-SULFATE 6-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047119939" description="Heparan-sulfate 6-O-sulfotransferase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005100156.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="50870" checksum="CAA28D2D10CA5F64" modified="2025-10-08" version="1">MSTKFRNILIGLTLMVLVFCLLSVYTCSGSSCFGMTSPTAAPFKNDFDAYLQGKLLKHSFSQSSLDRSRHVNLEADDVLVYLHIQKTGGATFGRHLVHNLDVQPPCECEPGVKKCECFTRNNRVWLFSRHSTGWMCGVHADWTELHDCVDEWFQENDVKSRKNRRYHYITFLRDPLPRFLSEWQHVRRGATWKAARLHCNGHEATLEEVPFCYTGEDWTDVTFEEFISCKHNLAFNRMTRMLANLTKVNCYDWSSLEPAFVNSTLLASAKENLLEFAFFGIVEEQRKTQFLFERTFGLRFIENFEQRENTHVSRIDITGEMQQRVIHANGLDVQLYQYAKDMFLQRVRAMEKKLNYTVEEYFESIRDGAVEEEEEETVDEGRMFEDPLDDEAEEAGGEFSPPRRSGPVRSSRRGESPNLRPMRTLQRRQHVEGREGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTZ6</accession>
    <name>A0ABM0JTZ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101851202 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101440.1">
        <property type="nucleotide sequence ID" value="XM_005101383.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851202"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101440.1"/>
        </source>
    </evidence>
    <sequence length="1385" mass="148877" checksum="A2989E1C407F886B" modified="2025-10-08" version="1">MYVYLSLHSSPNTSQAPHVWVHALRVDWFSNFSLCLGNKMSLPERPANVLKEGKEGKDRRRLVSITRVADQNSVPQEITIVKDLDSFGLLNSSGYQNSGDRRSGTWARKFDSHSSDMNEWTPSQSKMKKIKFEWTLDESPDDSSRPQEASDVSSHDVNGKAINDSSRLDDTTDIFPDLYGSSDISPNISDSSDISSPAPGFDRGKRSRSSGVLGDGGHSSDDKGQRSDSYATQAVASERNGDGVSVADVKIELESDEERVATGAMPRLPSFSQLSQSLIKMREGSCSSASKKRRLSGPVCVSPKQRSALTKQQRLILPKSPQVFSNPESTLHKQGSVKQQEAGNPSPNTPIGGKKGSDTFPPETGRPEGEICDGNPRVVMERVCEKLLPRSSSVSACVMGDMSLPPSSSSFSSSSSSALASASASAVLPKHVVDQLLSRDGCKTRSTSSLVVGGTSLSLSSSSSSASAVLSKYVVDQLVSQDSGGTVSASSHVEGSASLSPSSSSASASAVLPKHVVDQLLSRDSGRTLSAGGLNSLKGTNCLYFLEVSTRPTPQAQSKKPHSGLPLHADVASSQSFAKQRNLTPAPLDTTPLNNGGGVSVVISDKEKSIFVKKKTPVIIKEQSPIVVIQKLPPVVKDKSLSVEESSPPVVIKEKAPIVIKEKSPIVIKEKSHVVDKAKSPVVNKEKSPLTTVKEKSPDVNKEKSTLITVKEKSPVVNKEKSPLTTVKEKSPDVNKDKSPLITVTEKSPVVKEKSPLVTVKENSSNVKENSSILSQGSSTAVGEKSSILKRKASVTEEESMKSRLTRARNSEPPLKRSVRLSAKSNVTAARERRREVGKALERRRNHPLRLAAKKKLQVKLKFQRGDGRGQPGQWISLLRDVHTRKDLKKGTGSGKQRKLANDKLRSSNEGNVISSCARNRKDVTAEVDIVEHAVSTSVSGTGGSKDISASKSPQGSKDISLSNSAKDVCLAKGNGNRETSVSLNDVMMEHEGSKDLEVLQDASDSSQLPFPPPPPPPPLPLSPSVTTTLREEEKVELQLSSSSQEKRKRSRVGRLVDKGFMETASSKEKVIISPPSSLAWVNSAGKAILAPVVRHGIDQLVSKGCSQVYLEMNSTNQCYKVCTKSKPFKLLLVGRSLNRGSAHKSPSASRSVNVGEQTVNKNESGELASKDCQRVNGDKSGELSKKDCRTVNAKNSREFRQKGRPRKNKKKSGALAKKGLPTENANKSGQSTDTGTQTMISNESGESSDGDTGPCAVAPTSVVAKDNDCLSDQPQTLPETQVVEEERQGPSSGGALQKPLKEWSHADVADWLERLNLLWVLPDFRQVDGPSMVELVSGFTLNSSLIMQYLKEMGLSLAENLRMCAALRALADSPLHTLPKMASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU64</accession>
    <name>A0ABM0JU64_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101861292</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101567.2">
        <property type="nucleotide sequence ID" value="XM_005101510.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861292"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052795">
        <property type="entry name" value="RREB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451:SF1">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1090"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1207"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1772"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1840"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="2087"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="2240"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="2268"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="960"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1341"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1524"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1641"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1878"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1923"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1968"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2063"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2150"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2302"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1343"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1359"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1444"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1528"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1547"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1574"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1650"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1923"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2150"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2185"/>
            <end position="2197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2318"/>
            <end position="2338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101567.2"/>
        </source>
    </evidence>
    <sequence length="2384" mass="262857" checksum="D00D9C119F3B10DD" modified="2025-10-08" version="1">MSRRKQSRPRPVKAVGEAVFPLAPSPKAPCDSHGQADDDDDNDIVVRDKLIIALSPSRDGDDDDDDDGSITRFTDDSRANRTMSVSTLQNSVLATGPPSHPIPPNFLLPSPTSAFSVPPPIPYLPFAHPSTSDYPTTPSSSKFNPQAGMARKKRSPSNRKWAQQITSPAEADILKCDICSAQGAEERKTCTLVEKQDYYIENDGTLTVRNGVCTRRLVLGLFGNIANSPKKYKDDLGENFMKFLLNLDQILKNQHMVCPDESSLQAITAQNVLMTHLGTAKLQTALSSRKRPREISGLDGRNQTIKGAPQLAEDLTLSDDVGNETTADEKSAPRLPDNFLSFPSDSGSALSQFTSDDKTRNEPVVGKKTAVFPSNEVSGDEGSVSLVAGLMGGFSDPATPDDSAQMSSRPESPTGSIGQIDGSKQMANTKRGSKILPVASVNGQTHYICPVCSLELSNDHELTVHIRSHNQSSQQALPNTCTICGKTLSSQSSLDRHMLVHSGERPFKCKTCGMSFTTNGNMHRHSRIHAKNGMAAMAKSTVRKPSEPKPGKKDTFAFDKMGMTGAGPSQSPFHTMMPSEYGNKLERMKNHQEQERGAEFLQQYYNDVNKLKAMGMAGMAGYMFPFTAPHHPAFPFHQMFSDPTRVLPFMPRMMDPVTGEIFAKRARISQQMMAPMRPPSPDLRSSKPSTCTVCKAEFSSEFALESHMESHVIVDTQLEAESGNACKTCQVVAKSEESLLLHTLTHHMPDEELADLDTPPKTGSSSETADGDNSSNNNNNNNDNNSNNNTDNDSIKSGFQELGFASFTTKKFPLIAKAFCESKTILKSESEPVFKCQECGKGFPVEGARDLHEASHLPEEYTTCPKCNCHFSDSLRLQEHMLKHVSDIKFDEYLSKHESEEEAMPQNYFLAQFGLISKDSPEEIGQKHSIKTEDDESIDLSVNDNDDYAMSDAEDRMDFDNCKEEESEPCASPGVTAIKKEESATDSKLRLTNFFLPSSKSAVRVPETKGFPLLIHQTKQSDRPTSVPVRSSSESDDLSGQTDSQTTIFESSVVARAVVHPPVFPCKHCDVILASPKDLEAHQLTHKSQYECLICNYTSTDKSTLQRHMRTHSGERPYKCKICEYSFTTKANCERHLRQRHGLHKDQLHEYLTSNKYVIASRSLSPSDSPTPQSFHETVCKSCGLDCVNSKGLRQHLQNAPDCRMGFICKKCDAPFSTKDSVMEHMNRHHPEVRGPICERFICRAEVMSSSLLDPNNKLSAPPPAHSTPASADKPKEKPSWLKEISIAPHRGDSAVVKKFKSNTLTSDFSPQDVDTEGPLDFSKQVKPGLTVEAPSLLAQMSGGATSPAVDTSTEDQPMDLSVSSQKPSASATLDKVQDCGVSHSFLHQEPYGLQGFNKEKSTASFSGSTSSIKVKTDTLPTHNSQLRESDGNNNQLSPLFTMSSGSSNTSIPSSLHLPPDDASSLSPAPHTPKHPAFPQFLPMVAGYPSLLSAAGPQSMSFQAHPALTQRLALMSRLHPSFVPPTGKMSTATPNVSGQAPNYKSMEVTDSKTDSLKLEESVDQQRNNKRKDRSSKETEKSDIKLVNKPIVDLIDIKKKKPKSSQGSSCESDSSCELASVNKILDATDAQNFQDYLIIPETEDEQDNKSESVQSGDESNQSLENMFSQSQSLLAGQLTAKLSDSSDKDSADKDKNLLAEDMPITINMALIDGNIPASVHEKTFQACLEQKMEDPSNMSEQAIAELIEKVSRENVNSPAKKKRNSYADSPHKFTCPYCPRCFPWLSSLNRHLLTHTGQKPFKCPRCPVTFSTKSNRERHLIRKHNVNMLDPACRATMDRPYKCHLCVFSSFSTQSNLVKHYKDRHNGMSPPAHLLEAMEKGSDGEGEDSNGNPINGPSYEDEEEFNLSEMRNGLSDKEIMFHNYSQDSDSNQGSNGTTPSVRDPHKKRNAIFNFTNDIEGKNGLHATVNTSNSSSVHAISPKPESAQPSTTNRPGIDDTVLTDTMKKFLDKSVRQALEDSHRRAMEEGSPFIITPAIEKHLRNLSPGEELLVEDTIKRWKNDTDSVSRKLQLKSPKESSSSSSPDLPFKCYLCEASYTSRVECLQHQSQSHSAEWDILKDKNDVGSIQVFATRLDKMIDKQSKKGKEVLAKQQAKEKEEVGDATEKAASEEDNTKCREVPGGVLTRSKDNKVERNKDGDETESIDGEAINHAPSYECSGDEGTDPSFLQEVVSTDYLQRKVHCSLCPKRFWCLQDLRRHMRSHTGEHPFSCNLCPKKFTLKHSLNRHMAKHHAGAGMSLDAMSDDEESEYDVGGQSSKPTKDSTKRTSKSSKEERAETKEENEDNDDMLHNLLGVESATIDQLLESKDSAASLLGVGEGKTQPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV06</accession>
    <name>A0ABM0JV06_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLOC-1-related complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102153.1">
        <property type="nucleotide sequence ID" value="XM_005102096.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859341"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032143">
        <property type="entry name" value="BORCS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397:SF1">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7 BORSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16088">
        <property type="entry name" value="BORCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005102153.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11875" checksum="475BFA135744A57D" modified="2025-10-08" version="1">MAATRTSASSNWNQETKARLNEKITANVNDLGSLARQVIRGSKSNEFLAQAAKNFASQESYVHNSHETMRKMDLMRSQLEFQQSAIARSLSYLDEIQDQITSIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVX3</accession>
    <name>A0ABM0JVX3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Uncharacterized protein LOC101855272</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4" type="primary">LOC101855272</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102761.2">
        <property type="nucleotide sequence ID" value="XM_005102704.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005102762.2">
        <property type="nucleotide sequence ID" value="XM_005102705.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005102763.2">
        <property type="nucleotide sequence ID" value="XM_005102706.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855272"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005102761.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102762.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005102763.2"/>
        </source>
    </evidence>
    <sequence length="156" mass="17814" checksum="98F52C7ED4E4FA00" modified="2025-10-08" version="1">MDGFRINFGELHGDMKRFLELVVFTFNNSAPHNLRQVTIISDILRPNDSIFKYDAELAIQKFFVIHDLLNALLKRGYNQIIVNYQGWFGEQRNKLLWLLGLVKMSLIQLRLEGYNVQEDVSVLSAGIGGINTSTQKAIGDSTMSHIDELVFALRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYD9</accession>
    <name>A0ABM0JYD9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859262</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104469.1">
        <property type="nucleotide sequence ID" value="XM_005104412.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859262"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="15"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104469.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22305" checksum="1EC743417DE279D8" modified="2025-10-08" version="1">MRSNMDNIKMINESVLIGFYEAEPCLWNPLDPGYTDNDLRRNALQKILILGKIQDNGDNNVTALEKRFKRYVNKYVKELYKVNEDPLKAYKPRWEHYDRLDKFLNPLFQQKISTCPAKTNAAAKRPPPSQGAGPSSANGNTPSKKKTLNPSMSAAPETAPHARFGKHVATVLDSFDRDDAAAAVIEIQEVLIKYVTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K207</accession>
    <name>A0ABM0K207_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">SUMO-conjugating enzyme UBC9-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC101853813</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106871.1">
        <property type="nucleotide sequence ID" value="XM_005106814.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005106872.1">
        <property type="nucleotide sequence ID" value="XM_005106815.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005106873.1">
        <property type="nucleotide sequence ID" value="XM_005106816.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853813"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005106871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005106872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005106873.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18447" checksum="D2A07BFA3FC5FC2E" modified="2025-10-08" version="1">MSGIALGRLGEERKAWRKDHPFGFVAKPTKNPDGTLNLLNWECRIPGKKGTPWEGGLYMLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSLLDEEKDWRPAVTIKQILLGIQELLNEPNIKDPAQAEAYTIYCQNRAEYERRVREQASRFRDPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2E0</accession>
    <name>A0ABM0K2E0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101855133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107130.1">
        <property type="nucleotide sequence ID" value="XM_005107073.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855133"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045154352" evidence="2">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107130.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="10992" checksum="E41C3D292355135F" modified="2025-10-08" version="1">MLPRLVQLLVLLLAALMATRARSLSKRQAVTFTGVLPGNYTIPYFIDSRGRYILMTPANFPQLFRPAIPAGQGQGQQTAGQGQGQQPTGQGQQPAGQGQQQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2H4</accession>
    <name>A0ABM0K2H4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101851294 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107200.1">
        <property type="nucleotide sequence ID" value="XM_005107143.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851294"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047515662" evidence="1">
        <location>
            <begin position="30"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107200.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18133" checksum="69EC056195C1FFA2" modified="2025-10-08" version="1">MADHVTSISQTATVMVVTLLAFGLRPSACLCETRCEQSIPSLNRLRTYWSRSFKRVGEQRLSFEQFLLSLVQASENGNPVMRRLRSSILRIIGRYQDCVMACEHQFSKRSGRAQARGWTLDALCQRLLLYQVEQQSRQQLPRSLSQYCSSRVADRLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2S8</accession>
    <name>A0ABM0K2S8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101848841</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005107439.1">
        <property type="nucleotide sequence ID" value="XM_005107382.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848841"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="31"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="142"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="265"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005107439.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="44887" checksum="41F9EFE43BAB4346" modified="2025-10-08" version="1">MAVNGVKNGSHYTELNRHYAEECSQDDVGSFLFTSESVGEGHPDKICDQISDAILDAHLKQDPNAMVACESVTKTGMILVAGEISSQANVDYQKVIRDTIKQIGYDDSSKGFDYKTCNVLIALEEQSPDIAQGVHVGKDQDDIGAGDQGLMFGYATDETAECMPLTVVLSHQLNAKIAELRRSGVLPWARPDTKTQVTVEYRYIKGAAVPQRVHTIVISAQHDENVTLEQLRKDLREKVIQAVIPSKYLDSNTVFHLQPSGKFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKAGLCKRVLVQVSYAIGIAEPLSITVFSYGTSQKSERELLDIVKKNFDLRPGRIVKELKLRNPIYQNTACYGHFGRNEFTWEQPKKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3D3</accession>
    <name>A0ABM0K3D3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell cycle serine/threonine-protein kinase CDC5/MSD2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107823.1">
        <property type="nucleotide sequence ID" value="XM_005107766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857901"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005107823.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31197" checksum="805EBDB07149F57D" modified="2025-10-08" version="1">MERAVKCPDEVAILMELHRSDLSHALCDISTDEASRYFTQLTDAVSFLHQHCLVHGDLKLRNVFISHCGNAVLGDFGQAQILPKNSTSSKRWGGTLHYWAPEYEEGEPVDDVFKLESYSLGLCLWALLFVKEPKSGTNFLQKLKDKVLIPDLHRQCVERLLCPSPSDRATVVEIQQMLHAHGQPKSRNPTASVEEIQQLHHINEQTEARDPTASVEEIQQLHLINEQTEARDPTDAADPSPVPPSAASCHGHSQIRERYKNNTLKSRARKEKLKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3Z2</accession>
    <name>A0ABM0K3Z2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS12m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101851221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108209.1">
        <property type="nucleotide sequence ID" value="XM_005108152.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851221"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005108209.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27310" checksum="345AB3CC688EB567" modified="2025-10-08" version="1">MIPASAKGNYSPFSIDLDQGGYPSFLNQGTFLDFHHLTPLELRREKETMSFLRQSRKVLSSVTHCVSQYLAGSSVAVNTARPTVLSTFSTLCHRLQHPVQALAAQPSHNGQHSALISRSLLQNIRRCEFAPQRSISLEYMHRKGLYKKERRKKNSPLEGRPQLKGVVLKTLIKKPKKPNSANRKCVKLRLSTGKEAIAYVPGEGHNLQEHNIVLVQGGKLQDTPGVKLVCIRGKYDLPLVKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K400</accession>
    <name>A0ABM0K400_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101853644</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108219.1">
        <property type="nucleotide sequence ID" value="XM_005108162.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853644"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055492">
        <property type="entry name" value="DUF7064"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34717">
        <property type="entry name" value="EG:BACR7A4.20 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34717:SF1">
        <property type="entry name" value="EG:BACR7A4.20 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23212">
        <property type="entry name" value="DUF7064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7064" evidence="1">
        <location>
            <begin position="282"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005108219.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="48554" checksum="EFE5D63A0A9B1508" modified="2025-10-08" version="1">MTLFLVFSAVSTSILFWLLAQWLPHKLTTVKVPRIYTQPSFHYPIKYWIFRLVLWTRKICQNQLRLRRQQASSSDAGYGVKSRNSPEEMDKLQELPQDMPKAVDAVYINGGNSEGVFMVTATARRQDNFVQTVLYLRIPSIGLLEMPTLPDTWLQDTASRSGFSGGGLTLTPISPMESWSITFDGTMRIAETGKSVKVDFNLIWKAYTKCFDFDTDLHPHVMADGIARETWSREYFDTLKRAHQTHYEQFGEVSGILHIDGHPDQRIRVQGVRDHSYGNIRDWKYFHRYALNYAHLEDGSALCVGAICMPMSLSRLVVGYFFHPDGSMDAVSETDFEFYNWGEDGQPPEKLSLKFTAGGQKYDLTCEVIQCPIFYMGEDWDARIFERFCNYTVNGIRGWGISEWDYRNYDGKEVELTQRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4T3</accession>
    <name>A0ABM0K4T3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell cycle checkpoint protein RAD17 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101855291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108745.1">
        <property type="nucleotide sequence ID" value="XM_005108688.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855291"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="641"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005108745.1"/>
        </source>
    </evidence>
    <sequence length="712" mass="79631" checksum="63450C75E32CA0E8" modified="2025-10-08" version="1">MDCLDSDDDVQFVKIDPVKSKVKPKKSVTWVSSSFGDFGPNLSTPISKTKIKGGSLSDLKRNQTDSNISVPQTSVFAFTSQHESRKRPRESDHCITSRLPSHSKTCSSKDLWCDKYRPLHRNDLAVHKKKVEELCEWLARAKSHWKKHAAPILLLTGPPGSGKTACVQVLCAQLGMDVQEWVTNLEQVADQWSGEDFHRSEKSRVDVYMSQSQSSQFHNFLVRANKYPALELMGSAGHVSESDGGNVRGHSACHSTTVLVEDMPNVFFRDPPQFHNILRKYHYSGHSPIVFIMSDSTSSTSSVQKLFPKDLQHQLGVVSISLNPVAPTLLLKLLNKVMSQEARQAQVTQPNSSVIEQIALSSNGDIRSALNSLQFACRMDTADLKPPVSSAPRGRLKKSGTDSKLKYRTSGKEDVASSGGSVASAIGAKDTSIFLFQAVGKILYLKRGDPSTQADHPCLPRHLELHDRHPLLMNPEEVAAKSHVSGDFFTTFLHENYVEFLSSVEDLERASEYFSDADYMSTLWAAREELQQYSVSVATRGFIHSNSDVVRHDSTRKNHGWRPLHKSRWFATNKQANENITTARQIFQGYHWEPEVLCSEILPYISLTNPTLHDTGQISFVQEMTQFSQWKRSSRTRLVRLDEKDVASDEEEGEAGGPTQMKTGAPVTDDKARDGQSKEESVEGDSFLSSSQTNVQNVEKEEEEILIEEYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K538</accession>
    <name>A0ABM0K538_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Retinal guanylyl cyclase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101846250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108960.1">
        <property type="nucleotide sequence ID" value="XM_005108903.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846250"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF8">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="82"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005108960.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36387" checksum="138C6C5F9702BCDF" modified="2025-10-08" version="1">MPALLCVRCITKTPPSHRHVARKGSFVASDTLEFCLRACALWWLPLLMTSVPAVATSGVQKNITIGVMLSMSGPKSLGVEARRAIELSFQRINDSPQYSAITDQDYVFQYLLDDVPCDPSDAFAAMLDIFSRSGEHLHGLAQDAFVGPSCDEVCQPGGRLARYYDVLMISYGCESSIFDDKEEFPTFGRTTPTFKDMEAFFAEVIAHYKWPRVTLVTMTTPVWQETLTEFESRIGSKSVQVMRLSLESVTFIRSQEFVEVLKNESERSRVFVLLMYSDAMLEFMRQADRAGLRDGRYAFLSVDYAGSSAHTGDLTFLDVLVYGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5G2</accession>
    <name>A0ABM0K5G2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005109181.1">
        <property type="nucleotide sequence ID" value="XM_005109124.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858896"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="2">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109181.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25465" checksum="3D24E732090CA5B5" modified="2025-10-08" version="1">MSKRTVQFFYDVVSPYSLFAFEVLCRYKNVWNLDIKWRPFFLGGIMQGSGNKPPAANPNKAIYTFKDSERIAKYFDVPYKVPPDPTDFMFNNGSMTAQRFLCLVDMERPEMLEQITRELWMRAWAREQDIVQPDGIAAAATAAGLPKDITESFLSRVKSDEVKKRLRDTTQEALDLGAFGSPIIVFDVNGQKEWVFGCDRFPIMAHMMGLKWEGPKPGSPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K738</accession>
    <name>A0ABM0K738_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lengsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamate-ammonia ligase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101860451</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Dodecamer. Interacts with BFSP2 and VIM.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110298.2">
        <property type="nucleotide sequence ID" value="XM_005110241.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860451"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407:SF1">
        <property type="entry name" value="LENGSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="9">
        <location>
            <begin position="137"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005110298.2"/>
        </source>
    </evidence>
    <sequence length="473" mass="53294" checksum="F3B07D2A9ADF3E09" modified="2025-10-08" version="1">MPLTTNNRDGPAVVETPLYDDVDGQPKSQERLLDYDMVLCTACDVNGSPRGHFVMKNALASLLEEGLEVPFTTGVLGFKSEVPTSVERYRGSSPASRLVPDVSTFKPISWMCQDGRKIGHVLCDLYTGNGTPDPHSPRQLALRQLARLRELGFSIMSAHETEYFVYHRGTLEPLGGQVKDVCNHLHMMGEQKMLYQQMTDLIASGVPIETFMKEYGPGQIEFSMEPQYGIKMADVTHRLRYLAKSVCKRSGFEPSFMTRPQSEFVSSGYHFNHSLWTLDGRNAFYDPEGDHTCSDVIRHWIAGLIKHGDALTCLYSPTVNCYERLHGFFAPTDNVWNYDDRNARLRVKTKAKNVHIEERTPSSACNPYLVLAGLLAAGMDGLVNKLECPPNREFRPFLKGDQKSVPINPLPKSLEESLEALREDEELKTALGEEFVEEYTALIQECQLDKLSNATPLGTSERFEAQRDLYFCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7L1</accession>
    <name>A0ABM0K7L1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101849801</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005110655.1">
        <property type="nucleotide sequence ID" value="XM_005110598.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849801"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17487">
        <property type="entry name" value="MFS_MFSD5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005110655.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="52147" checksum="928B9749F6E5255C" modified="2025-10-08" version="1">MMMLVYFTFGALSLLCLLFQYWAHRTRRNATVGNNPQFIKFQRGYFAVYLVAMFADWLQGPYLYKLYSYYNFNEQQIAVLYVFGFASSVIFGAWTPIAADQFGRKKLCIFFTVAYSVSCFMKMSRSYGILLIGRLLGGLATSVLFTAFEAWYIHEHLETHDFPKEWIPITFQRASMWNGLLAVTAGVTTNIFSEWMALGPVAPYMMAIPFLIFVGVIITTHWNENYAMHKIKFGRLCYEGLKDIITNRRIFLIGAIEALFESVVYIVIFLWTPILEPGQPSLGIVFSCFMVCILIGQAVFQILTSRGVAITKILMFVVILSLLSILTCVYSTHPRTRHLNTSLVAFLCFQFCVGLYFPAMNVLRVKVIPEPHRYAIMNWFRVPLNLISCAVLMLLHEDAFLHGNHLIFVVCLGLLGLMLLATYRLIKIPRPQEELDEEEGSGLILMETEHIHNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8E3</accession>
    <name>A0ABM0K8E3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Farnesoate epoxidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101855383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111238.1">
        <property type="nucleotide sequence ID" value="XM_005111181.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855383"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF31">
        <property type="entry name" value="CYTOCHROME P450 307A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005111238.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41496" checksum="1D76F8EC4D35E1E1" modified="2025-10-08" version="1">MKTTSKELCHRLTQYEGDIPISIELARYIRWVVALLLKGPETCEKDLDAMLEYIDRTNECFIFEKEVVLETVPFAPHIPGLGLKKLVGDLKVAQEVMRQRFFLAIRETYQKGERTGIVTDMLDQQAELKEKGNASEMPDELIIGLVQDIAAAAYATTVATLKTLFLQLVVDQKLQDRIHAEICEVIGDESPSFDHKRHMHYTEAAILETLRYSSVVPLLLPHYANGDIHFEGHFIPKGTFLILNAFYFHHRDDAFEDPWKFKPERFLDSEGQLLDPEHPTRQKLIPFGTGKRSCPGESFARIRVFFIVVTLLQKYRFLPPVDDPLPSVHPRDWKIQAVISPDEYKCRMEPRLKGEAKTCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8N0</accession>
    <name>A0ABM0K8N0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101862462</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101862462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111430.1">
        <property type="nucleotide sequence ID" value="XM_005111373.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862462"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005111430.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="67366" checksum="8E8A66BE797D0089" modified="2025-10-08" version="1">MRYCVAANCTAPHKGLGESVFGFPKDPVLRAKWIKFVRDKRGDFQGPSKYSVLCQYHFTHDCFQNEMAVRMGFVKKKIINKDAVPTIHRPPKLKKTETDEPRGKRLKAKAVIKMGAFQRVSARTTARTLRNGAVLRYADADESDAQAESHDASDGDSSSGSGSPHLSTKDPKPGYNPEEEMDFTEINHGIAGNEIMCSLSEADRDDSAASLDEPNHVNSVNVNSTLVVKRELDGTGAHYCGDSHRGRSHNSVGSPLRDASFPVKIKEEAVETLSGGLDVVPADLQRVPTLSSHNSPGCSPKFINQLGAESAPIPATPQINETSGHLYEHMKISTKTFYMHRKDHELFPSAPTSHNGEQSAGLPVTSMSATTSLTSVTSSSVAMPTLSVSRTSENGVIRLLPFSPHLKPQAQPPVVSNSSSPGRESSVRDNVGVNDRANRTRDKAISRVCESGNFDTSEEEVSADGLDSSWGAGSDDNASPREMGVVDLDDIEVTGGLDISVDEILEENDDHYPTTSAANMKKASSSSTRTTIKSSSMCHKIGPRSYKLRKSRLSDDTVAAPELSNRSTQTASGRAEGQRYTLQVDPTTLRDKKLFLKEMERIRLFMMCKGEDAIVHLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8X7</accession>
    <name>A0ABM0K8X7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Submandibular gland secretory Glx-rich protein CA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111655.2">
        <property type="nucleotide sequence ID" value="XM_005111598.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855386"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005111655.2"/>
        </source>
    </evidence>
    <sequence length="224" mass="22777" checksum="D4B2D5035FAD04AF" modified="2025-10-08" version="1">MPAVGKKSGEGAPGGEGEDAGTGGDEDKEKEKEEEEGKVPVTEEVMVAQTAAPTGEDLANPGYSAELDNLPAPPTDGHTDSGGQQQEEGEKTTQEETAADSQEASAGQSEETIVVTSQETTAVTSEGEKQAEEGNKEEEEKQQQVEEQAGQGSEVVEKAGEGGEGGEGEGGTQQEASGEQQQTEASEETAAADASEEQKEGSGEQADASGNKGGGDVTQSQSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8Z4</accession>
    <name>A0ABM0K8Z4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101848397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111709.1">
        <property type="nucleotide sequence ID" value="XM_005111652.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848397"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111709.1"/>
        </source>
    </evidence>
    <sequence length="720" mass="82026" checksum="C8E0955366D7B4A5" modified="2025-10-08" version="1">MEVTVKAFLQRADDNREVRRLSLLLGPGGAMFKSLSGKVASAFPGLSGKKFVITWEDPDGDFVQMSTDEELQEALTHSSTGRLKVYINVVDGQSGNVEQMMEEEAGLSTDPESEVTRVRYNRDDPIAVNHEGLPLPQAPPTSLCGMFGQQGGLGCRRRRGQNHGPWKRRHQSPAGPCGPCDGQRQMAQGPLAGKREKRCEKRDWKKALRESVPVSQRRWAKIYVHNWRKENLENVSTTTFSDSGQEKKGKTMTREEAGVPEAYEVWLVKVLTKFHKRWETAEVCAAGHDGSDSDEGGAVSNMATLRKSVPVEFRRWMRWYLARRYDKRAAPELRCASPGRKGHRMGKGQGACEGHLRGEGHPSGKLSQQGCKGRPKCERPTMDESRPGCKNRPQGCRKDKAPNLGEDGRGKCWRKSQASGFRPGHLSSQVPRQIRSWTKWFILTWRLDHQIPTSVPAHLSDTGKVKADNAKDAGVPEDYVTWLLRFLPRWHVRTGQVDQSKVDVPEVRMGQLKELVPREFRDWVKRYLYRHYSHHPARRGGERGEEEEEERYRRWLQVFKKKWQLQQVTSGDLDPLCPSSSSEEEGEEPGAAIVTSDPDTDVEVMETSMKHLRLGREIPQRDGQFAVTAGRVNLPDSDNDDNGRDAFKGKMPRSPAFRRFARELLYDWDGRSPTDDTDNDMELPPRVYRWLGRVMKRVEKKRTRRERKAAKQEMEAVRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9J4</accession>
    <name>A0ABM0K9J4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101853426</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112148.2">
        <property type="nucleotide sequence ID" value="XM_005112091.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853426"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112148.2"/>
        </source>
    </evidence>
    <sequence length="301" mass="33616" checksum="FAE074B0C14CCB9B" modified="2025-10-08" version="1">MSVDFINIHIQSLEFHKIKKLFTAWLWNPGRRVKSWHSWFSRRQAHLSTQHSVLGGGEATNNGYTRRKMADSGVNGKDNEAATGDVEAPPTYTERDNVNARGDGLPTYHEASANQEPPPSYDSLYGRMKAAKRESDGTVGFLKSFLVIILSTIGFTILLAIFMAVPVSMIVMGSVYLDDCPAERMIPIYLIVAGAFGAAKNLFSLVQRCRKSEQEREEDQKKVNPVEGIVNCFLFGWFIAGCVFIYRTDDRSSVETDPNYCDPTLYWFAFWITTAAYIIMAASCCCVCMVGCIAACFAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9L7</accession>
    <name>A0ABM0K9L7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Cytochrome P450 4F4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101845740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112203.1">
        <property type="nucleotide sequence ID" value="XM_005112146.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012945718.1">
        <property type="nucleotide sequence ID" value="XM_013090264.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845740"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20659">
        <property type="entry name" value="CYP4B_4F-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945718.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="57483" checksum="5E8D05CDB17A1AEE" modified="2025-10-08" version="1">MLALYILVAVTCVLVVKYLRHFLEHRRTYSQLPGDNDLHWLLGNIHKYPGFNEAGLKFDFGKSEEFKYFHRIWVGPFLAVIQCYHPESIRKVINSSAPKPRNLSLFSSSYDMGVSWLGEGLILTNGARWSRNRRLLTPAFHFDILKNYMKVYNSCVSLMQGQILEASKAGKSFDLQSLVHKCTLDVILCCAFSYQSNCQTEEEASEYINAIEELQVRWSERTLNPLQYIEFMYKLTPGGRRFYHLCDIAHREAEGLIAKRQKELAGNPDAVGQRKVRDFLDTLLTARDEEGKGLTPLEIRDEVDTFMFAGHDTTASGIMWTLVSLSQHPDYQDQVYREVKAVLGDRKELQWEDLSELPFTTQCIKETLRLHSTVPVVERSLTEDITINGHTLPAGSRVALQLWMLHHNPHVWDEPFKFKPDRFHPNKVAKMDPYQFVPFSAGSRNCIGQNFAMNEMKVTVAKIINDFQLRPDADRVIEHKTSVTMKASEGAYMYATPRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9Q2</accession>
    <name>A0ABM0K9Q2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101846325</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101846325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112292.1">
        <property type="nucleotide sequence ID" value="XM_005112235.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846325"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005112292.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15205" checksum="107D48BE73A025EC" modified="2025-10-08" version="1">MEGLGKEGILKITGPVSDLAQDFELNVAKAEYSYIVGPSAKPILETDRNQGGTCVRLKEAECEADFRVKVSLRGTVGFPDEDRADEIPIAEIISDLIYEAEDGDESFERFHLGDDNDVIWTVGGKCHFYLTAPRRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA77</accession>
    <name>A0ABM0KA77_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC101855311</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101855311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112654.1">
        <property type="nucleotide sequence ID" value="XM_005112597.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005112655.1">
        <property type="nucleotide sequence ID" value="XM_005112598.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855311"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052281">
        <property type="entry name" value="GAREM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454">
        <property type="entry name" value="GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454:SF11">
        <property type="entry name" value="SERRANO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="3">
        <location>
            <begin position="243"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005112654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005112655.1"/>
        </source>
    </evidence>
    <sequence length="599" mass="66203" checksum="A33F36B37F3AB380" modified="2025-10-08" version="1">MLKWTKYGRNRDEEKRVDRIYENSQQQLDRKQVSFSEDSIAADTDSGCWVDRQGEGHVSSATCTGSPSFDVIDYTCTSVADISKGESEGKLPPLPRSDFPSAHQSTSSSLKHSLSSPVPIIVVQDCSGDSLTNSRILSKSSCEILGLQTAALPKQPVIPLLPSDSKMASELPDVTSSSVSNSNPEEEIIGPELPWENERLSVRELADKDVLPCVASFFPDHSGPDSEGQGLSPGLRLYARQPVLLHERAKSRQAKARTIYRDKGGAYYEVGQTLIIPDSYKGWFEIVPSDFSRSTCFQTIEEVAKTMPSRFFSRSHITAIRIEGEGDSQKYLERRVRAGSVLETKGLFTAKWKTQAVTGMLRKKTTEWLLQEVTYLKCLDKEEVEILVPLSHRGKFNAIYKRGQISQNAVYSMKDVLSDLTLPVKVRLLYGKAPVVPCIFTGMMILRDAKIGESVVGSTILNSRNVLFELPLGAPIKIRLATNDEALQEMTSYKDGQKLCRKYAHMYGSMIKLSPDLDTNQKTIMHVPTDPSLLEQADEALRALDLITDISLTGEPEDHLLDSASDSASTGSAEPSVVPKGGTLAELSEYRSRESQTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBF6</accession>
    <name>A0ABM0KBF6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101851472</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101851472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113545.2">
        <property type="nucleotide sequence ID" value="XM_005113488.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851472"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF390">
        <property type="entry name" value="ZINC FINGER PROTEIN 37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="582"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="609"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="699"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="728"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1073"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1084"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005113545.2"/>
        </source>
    </evidence>
    <sequence length="1276" mass="138998" checksum="DBFF87250ACCCFEB" modified="2025-10-08" version="1">MPHRSREIKIVGAEMKKKSAKGAESFEVITQEDETVCLSDDLSTVHSQLEDRLASTDAHFPADRGEGEKCEIEKAEDTEKVTEKSQSHLDIGVAVTSGVTETLESHNPCVQASSTKALCTSSLELRDSLGKCSTGSSDEAESSEVKRDSTGGTAGADVERSADVAGSPRTSPSGVCTGEGHKRGEEEEVDEILTEQGLDSSDSSLKRYATRGVKLDFSAVNSGKLTLTRGKSKSSQNWKGKTAHGESVVRGARRQTSKTLSRRKKVLLTSSCASALCDAFDPMVKKSSDSASVYSSTSTKLTQMQPKFSTTSNDQVQISSKRSRKSIHTIGNKKVTISEGAQQSLNNLCENSSVDGNVVSKSMPYFPKVVTLDKSLRPGKRGKVLSHQTNILARSELTDSAVWEKDGEKGTLVESAQVCTCGSLVCSTLASAERAKSLQIGTDCEKTGLLPTTKMSDLYDVATTKNSKLCQVPFASPHFPKDRLVQSNESGERQCAMTDVQKDADVEDNQDNRTLPQTTEDSVACPQCRRAFLVQAQLDYHLSSCHMTPDQTPGLTCRLCGLVAQSHFEMVAHRAGHGPQEFSCRFCHKQFRSEAYLNIHISALHTKSQACTCWQCGKRFNHPRYLRSHAKRHTGEKHHVCKICGFRFFEAHALRRHEETHKHKTQRQYAYICSKCHAGYNNKTNFVDHMNKHTGEKPYACPQCDKRFAYRSMLSRHKVYAHSSARPFSCEFCAKSFRFNSSLAEHRVLHTGVSRNVCGSCQKAFGAKSSLRQHQKRCRFRELLISSQTNLGSDSTMSECGASLQSINHVYVENSLTACTLQRELMFGSAKENPCPSQLNEVIVPRDSGELLLQQREASAPQHSQVILPQQNEVILPQQREVILSQQNEVILPQQREVILPQQRVILPQQSGSVTEQTEVLIPQQNEVILPQQNRAILPQLNEVLVESNFEEATVSSKVVLPLQPSGTDRNVVEGLSSNLTPPTLAGATDGLFFTDSASSKLSSTDVVIDFVQQQNAGPASMADNAAVSGQELPQSDIVESDYFICSGCDSVFDSLAVAQAHLLLGKCSSPDTAAPTGGVPHKPQSQSGSTEVSATSESLLFEAGAAEESSTLSAARETEALCPQSVPDNADCQRLQEVTVLDNAEHQSQSSQEVGAGVASLVLPSCVQIRTSDPSVLQEIVYTTTTPTEVDRLENSGLASDEQVKMSRAEILSSRSPSTGSGQVFQVSSDGAEQIQEVYVLPGESQEGIMELVKKFAQQEGVGTMQIVIQDLPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUX5</accession>
    <name>A0ABM0ZUX5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING finger protein 150</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101854003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012934961.1">
        <property type="nucleotide sequence ID" value="XM_013079507.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854003"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16668">
        <property type="entry name" value="RING-H2_RNF130-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF23">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012934961.1"/>
        </source>
    </evidence>
    <sequence length="612" mass="67146" checksum="F92EB4A72CC4F537" modified="2025-10-08" version="1">MDFRRHLSSLVQFSSSGMGSSILSRWWIDLCISKERATFIFIFVFAAVIPFAYCDDPHILQASHDEPTIFHHAKINITFRDRDNQETSSVFRGKFGINSEVHSVSGRLMHSLSFPIRGWKGSSTKPNHYGCTKYVNSKFPSGKWIALVERGECVFTKKIQVATHDHNASAIVIYNNASDGESDETIMDHLETDSISVFIGRKDGLRIAELVDSGITVDMNIIPDGEGRYPPLLPNGISKTSVLFVSISFIVLMIISLAWLLFYYIQRFRYSHAKERLARRLACAAKKAIAKTPQKTVKTGDKELEGDFDQCAVCIEPYKPQDVIRILPCRHVFHKSCVDPWLLDQRTCPMCKMDILRAFGMQIGGSQESVHADPELGPTSHPVTEEPEVSSSVDEGQSEEVKVLLVPHTCLHYHVDGNAGEGRGGGLTSSSAIEEEEEASASSHLIGAAAGGCEIRQFPPASSSSSSSSLLSSPKPLGKSSSSSSRAEKVDEDHDEQEMKALIRSDHEDSNMMEEAAAGGKEEEEESLERQCRPRAGSPSYDTTLICGDEEDSGRHRRSPSSGSMRKTKTAEDIALEGVHGSLSSLGGKQPAVGFQGRTITDEQIGTAESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVT0</accession>
    <name>A0ABM0ZVT0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal-transducing adaptor protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935569.1">
        <property type="nucleotide sequence ID" value="XM_013080115.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846122"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039111">
        <property type="entry name" value="STAP1/STAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16186:SF9">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16186">
        <property type="entry name" value="SIGNAL-TRANSDUCING ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935569.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25532" checksum="8D8266CE292933EE" modified="2025-10-08" version="1">MDSGQYVNIQRLKKFHEGWMEHKSQGRRQWTSIWGVLRGHMIFLFSSKDTSPEMMIGTLTINKDTRLEKKDGNEQTGYRFDLYCAKRVNTFKTTKFSERELWKAFIEGIARNTVPDSLDLLPGQIEHVRELLSIGVRLPSSAQIDRRSSEPAVVSSFSGGFDSPNGSTSGSYSQTDEDLNIPPEDYIEPTPVTTLTARHSFYADPSKTEPPRFALHMLDHNFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWL0</accession>
    <name>A0ABM0ZWL0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein bunched, class 1/class 3/D/E isoforms</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSC-22/Dip/Bun family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936006.2">
        <property type="nucleotide sequence ID" value="XM_013080552.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847095"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047862">
        <property type="entry name" value="TSC22/BUN_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF26">
        <property type="entry name" value="PROTEIN TSCT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01289">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012936006.2"/>
        </source>
    </evidence>
    <sequence length="274" mass="28025" checksum="337ABED87FEE00B3" modified="2025-10-08" version="1">MPQPPCGPSATSPAPARPAVEKTSCAITAVTTTLTTTSVTTGPLDPAILAVMRNNKTQTFLRKMDLVKRHLMYAVREEVEILKQQIGEMVERITQLEYENSVLKSEAKPETLNKLVVPRQVTQVTGQPPSATGVVQQLSGVVGGPLSTATPAPSAGGMGVGVVAGSTSVPAQPQQQPQQQQQQGGGVVASAATAAPTSVTVAAGSIPGGVVAQPQAGQPTVVASSQQGTLPPAQQQQQQQSLAAQVQQQQQQQQPPSSQTGQPASQVPAPGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXC1</accession>
    <name>A0ABM0ZXC1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Contactin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101861573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936437.1">
        <property type="nucleotide sequence ID" value="XM_013080983.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861573"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046530327" evidence="3">
        <location>
            <begin position="29"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="41"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="205"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="315"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="422"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="514"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="607"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="694"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="798"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="917"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="1022"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="1131"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012936437.1"/>
        </source>
    </evidence>
    <sequence length="1268" mass="142347" checksum="060DF7143169DA96" modified="2025-10-08" version="1">MPWTTSRLMEPGLLVVMMLMMAPVFVSGQETNDCPPNWFTFGGQCYHFVQKPLRTVQEAVLYCQRNHSSLLSVDTQSEHNFIQNWLLKQDGGRQEWLTSGFREASGRMVWTADKSEIDPDSHHFVSDAARDEDRKDPRNDLKHNRIVYRYFEDAQQYFWAWQRIMVARPFICEISQQDTWKMYQEERDFSFGTGIQDPNKWQVGPKIVGQSMDTVFFRVGDRMTPVVLECEATGNPAPSYRWIRRKVGDNGVEVVTKALGDRFTQTNGRLTIDSPSETLDISIYSCEASNKFGMVVSNPIKLTYGHIEIFSNLPPSPLIATKYKGAVLTCNPPQYTPAATFNWFKGDVRHFIRPSLNAQYFLSKGGGFYISEVQDSDEGGYYCTAFLAPGSGQELASLQTISVLSTIMQIDVVGSNANTYGPDIHDQFPQHFPELPFLGDTVSIECLAYGRLPLNYRWVREDAALNPRAKVTDHGRVLVIPDARLEDTGVYTCVVQGVSDTRNKSRQLTMNARPQFPYPLQDQHVDLGRPLTWRCDVIAVPRATYLWYKNGAQLATDNEAGYMVDGNILKIDSVDPDKHDGMYECEATNDHGTSRSSAQLRAVSFQPTFDSTPVESSKQAAVGGNVTIACRPQAAPRATIRWQKGGVDVGRVLPNGDLELTFLTLADSGTYTCLASNDLGEADNSCELQVVEGTVFTYEPADEDVNVGETAHLRCEASFDASKSDIIYLWKFNDHILDLNIQSRDSIHYRMPIREGQGTNGQLSLIAAKFEHEGLYTCMVSTVTGETSHSAYVTVKGPPGEAMGVHAYNTTKEYKGTVDLWWQPGTFRGYVVTKYTIQARSEFDGPDEWDNIAVDIPEDETQMETRPLWRSYRISSGLSPGTSYSFRVFCGCAEMGYGPPSRPSPIIKMYDAAPKYAPENVGGGGGSVGELEITWNPLPRELWGGPGIRYRVYYRRYFEQNTDNTQWQTSEEIRETSFYTVLEKDLYYTPFQVKVQAINNLGMGPNSTLEIVFSAEDMPAIQPTSISSEAINSTAGYVYWELTPRTRESLRGTVYAFQINYWNEGDTQCPGTYEDTALFTRIYGDVTQGLVVGMEPGGDYCVNLQFMNRAGLGSKTDNYYLGMNDAAPGRYPEYVTIMSHGEESVRVMFRGVSTIFGEDPLQGYKAWWWDMREDIRSAKVADFGKSMTGVIHGVEKDTIYKLRVLPYSNGGDGKKSSDVYFTLGGQVIYDPVTTIIRNSAPSATSAHALLMTSVALIFVHIRRWLHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXD7</accession>
    <name>A0ABM0ZXD7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Globin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Myoglobin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC106011421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the globin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936460.1">
        <property type="nucleotide sequence ID" value="XM_013081006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011421"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="4 9" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="11">
        <location>
            <begin position="30"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012936460.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25851" checksum="A1D04F954A49C8FB" modified="2025-10-08" version="1">MGCTFSFPSKQSAKSYRSWQLDEDDMYPPFPSEKEQEEAKEVWEAIKAQGYELELIRVLFSQLFHTFPKSLSLFKSSEGQRLTTFSSNWFDDPRFAEHLKKVTFAINNFVGYLDNEASFQTYATELRTLHARFRGIKKAHYKAMLETLDSAISHVIISEKDTESKVMAWRKLLQYLFTQLTKNLPNTKSRSTTTALDGRRYSETSLASTQELFGDALPHTDALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXM4</accession>
    <name>A0ABM0ZXM4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101861355</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936602.1">
        <property type="nucleotide sequence ID" value="XM_013081148.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861355"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936602.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="54078" checksum="6E9B694510633F36" modified="2025-10-08" version="1">MGLYKGKIPGFYFRSPGHLKMTKITSINSVDDAQLPSTENTPDSIPDLEHSVDMEGSGDPDDGTHELESDISPSVDSFPTTASGDEEQESPETAETATVSKPPMIKELALAFWFYIGSCGILKKYLGVKDYTEKPTNYEISSLPINYGCNTENALWVFPVISIITGYIQYEELNEERCRLLTFRPEVNYLSRKALAKNGFYYFGNGHRIACYFCKRWGTALGDPEGLQEIRSCHHTNCPMVTGEPCNNIPLSVSSCQDPTAESQTVAEQPTDENNDIPLGRWLDQAARDDVPVRRERLLSLQNDCGIEDHRRIMSPPLYPLLSRPETRRLYFPISIDSRIIENFSGAGFFFAEESICCFWCGIRFAFERVALQVVDIWELHAQEKPTCVYLILRMGLANVQRWSGHSQIQHSPLQEAAVSRPIQEEGETASSTCRACNRRPREVRFLPCGHVVYCADCASVQFCYDCHRPVHDRIRANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZA4</accession>
    <name>A0ABM0ZZA4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011684</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937599.1">
        <property type="nucleotide sequence ID" value="XM_013082145.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011684"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937599.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11970" checksum="F9BAC47E4B937582" modified="2025-10-08" version="1">MSQVTPAASPVPTTSSGRGSDCFSPHELFLRSLQKARNGHDLLASCPDHNQKTTTLSLPEYTPHAVRTPGAVVRETTVLSTRSEGKGDDISGLTSDLEEDYTLEVKVTFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0P1</accession>
    <name>A0ABM1A0P1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">LOC101862696</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
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        <property type="nucleotide sequence ID" value="XM_005089853.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938440.1">
        <property type="nucleotide sequence ID" value="XM_013082986.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862696"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14288">
        <property type="entry name" value="UBA_HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041918">
        <property type="entry name" value="UBA_HUWE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF913"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="1505"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="17">
        <location>
            <begin position="1771"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="16">
        <location>
            <begin position="4528"/>
            <end position="4864"/>
        </location>
    </feature>
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            <begin position="1119"/>
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        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="4831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005089910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012938440.1"/>
        </source>
    </evidence>
    <sequence length="4864" mass="523704" checksum="01175631D148DAFF" modified="2025-10-08" version="1">[encoded data, 4864 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4C5</accession>
    <name>A0ABM1A4C5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101847509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940593.1">
        <property type="nucleotide sequence ID" value="XM_013085139.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847509"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="238"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="760"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012940593.1"/>
        </source>
    </evidence>
    <sequence length="801" mass="89418" checksum="B872452449463BE0" modified="2025-10-08" version="1">MTMAEEIKKFKLREEKHVMTEVEYMAWSPSMDLLALGNKNGEVIVNRLSWQRVWSLSAPSEGDKVGGLAWRPDGKVIAVGYKSGIIRVCDVEKGDQVYIAAVKGAVTNVVWLEQSKQLSEGEEHYAEDNSENYLPSAKQQQTLYSERNVSKEQSGLEAYERFRYLTSQKELNLLIVGSDASEVSIFSYGAFPTAIVDLSSDEIPECMSVDDALISPDLSCLSIILKSTVEGIIQYRIKTMDTNLLIARHEEIRLLAAKYVMVASAQMELQVIIQQMCEAWEDILREMDSRLLKLAETKRKRADTSVGNDFLELLLFGTTSLDFESFLLTELTDKGLKKLGFSVENSYSNIQKLVVRQLQRVSQNITAHLSDLHGMSQWYDRYAVLGLRPEILRDAVRTAGAFSVSGSELQQVIDASMKNFKAFFRWLYIAIMRLSNEQLPPDLAKMTQHDINFVAEFLRDNFGEPEDPEPAAATAGDEGKSKPPQVFRLEKVGQYLKNEDVTQPPNYHENPWIQFLNAATFHKDSKVLYPSMLGKSLLQRKELLDKAVGNAVLEPAKVIGASMSPVSCFSLFSVKESPEPSSQPPKVCQFTDEDLGCIWTAYVQEYFPCKFLYIMCHPVSDVSSVELIKIHIGRIGDPDLDDSIQGLDRPPSDEHVFLDFAMFNSQTLTLLLSEAGDEEVSLLLQLPLSVLPKEHFTHLSPAALDRDLVLPALNAGPLLPAAGVNYQTNASGLAIAVGGIRTTASLLLKSQRRIRLFLLEEGDGDDDDDEDEDGPRSEAMMTMSRDGENGGDDDDKENMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4E6</accession>
    <name>A0ABM1A4E6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-1,3-glucan-binding protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940630.1">
        <property type="nucleotide sequence ID" value="XM_013085176.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861522"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046057812" evidence="2">
        <location>
            <begin position="18"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="165"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940630.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50331" checksum="F0DBE925C8791080" modified="2025-10-08" version="1">MLRSVVFTLLLLCHVEGASRVLLSLGYVGDSIQLSLKLTGSDAPAARDVTFMYSINGRESTGRAAPVGDEWQYEITLAERSGRFLVSAFAIYNIGGVPHTTAISRADATLNNGVTERRTAPKIPSRQIRGAVVFRDDFNSWNTHNWVPEVSMYGGYSGQFQAYTNDRKNVFTEHGLLYIQPTLTTDDHRFTEASLHTGVMDMQALYGTCTNHANSGCHREGKDGLLPPVMSGRINSVPTLKFGTVEVRARIPRGDWLHPAIWMRPRDDKYGHWPRSGEIDIMESRGNLGYFGIETLLSALHWGPSSDQDGSSKTSTHKRSSNWHSEYHTWKLEWTPTHMLFFVDNQEIMKIDPGSSFWHLGGFHGHNIWSSGGKMAPFDQEFGLTLSVGVGGTGAGIFWDGANYPTPKPWKNDSPTAMEDFWKARSQWRPTWKGRGAALIVDYVEFKSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A521</accession>
    <name>A0ABM1A521_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101852036</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940971.2">
        <property type="nucleotide sequence ID" value="XM_013085517.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852036"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012940971.2"/>
        </source>
    </evidence>
    <sequence length="202" mass="21913" checksum="FB051F3DEB953FAF" modified="2025-10-08" version="1">MGQASTMFMGGILERRLGPRITCLLGGWFMSLGVVLTYFSVQHSFALTVLTYGVMFGVGIGFGYAIPLGCAMKWFPNRKGLANGVVVAGFGGGAFIFNQVQTAFINPDNLKLGRGSPGETDEEGYFHDPEMLQRVPHVFLLLGGCYAGMQLFGSLLLCHPSEEYVKDSPSTMAEEMERVELIHSQRGNGAAPLMDCMSISPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5K4</accession>
    <name>A0ABM1A5K4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Isobutyryl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941253.1">
        <property type="nucleotide sequence ID" value="XM_013085799.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846440"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01162">
        <property type="entry name" value="IBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034178">
        <property type="entry name" value="IBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052547">
        <property type="entry name" value="Mito_Isobutyryl-CoADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43831">
        <property type="entry name" value="ISOBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43831:SF1">
        <property type="entry name" value="ISOBUTYRYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="44"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="160"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="265"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012941253.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="45970" checksum="0BD256A005E00890" modified="2025-10-08" version="1">MASLCVRHLPSVSRMLRKCVKHVVFGQRRTMLTGSCIDMSHGLNEEQVQIQQMALDFAKNEMAPNMQKWDEEEIFPVETMRKAASLGFGAVYCDEAFGGTGLSRLDASVIFEALATGCCSTTAYISIHNMCAWMVDEFGSDELRSKWIPELATMDKFASYCLTEPGAGSDAASLITSARKDGSDYVINGAKAFISGSGASDLYVLMCRTGQPGPKGVSCVLVEKDTPGLSFGKKEKKVGWNSHPARIVSFDDCRVPQSNLVGVEGQGFSIAMRGLNGGRINVASSSLGAAHASIEQARDHMKVRKQFNQPLENFQYLQFRLAEMATQLVASRLMVRNAAQALDRGDPNSVALCSMAKLFATEECFKICNDALQIFGGYGYLKDYPVQQYMRDTRVHCILEGSNEIMRMIVSRDLLTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5K8</accession>
    <name>A0ABM1A5K8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activating signal cointegrator 1 complex subunit 2 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941266.1">
        <property type="nucleotide sequence ID" value="XM_013085812.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849630"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941266.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="50866" checksum="421907A18A293F46" modified="2025-10-08" version="1">MDPGGKKNNNSEKNSGRKSEQKSGNKPDASEEKSSSSPGEEAAGAQVSERQSDSTPSVNAQDGARSPRRTRDQQPSLSDNLPPDLEPDRSTRQEILTIRTERALYKLRKDQANRLQAHRELPDSTPSVNTQRDLTWELLNMFRLYSSESRQQQRQQLQRQQLQRQQPQQQQPLQQQPLQQQPQQQQPLQQQPLQQQPQQQQPLQQQPLQPLQQQPLQQQPLQPLQQQPLQPLQQQPLQPLYQQPLQQQPLYQQPLHQQPLQQQSLQQQQVNQTQQEQAQQLQEHAFRLQEQIFWLQEQVLRLQQDARMLQVDGERAHQQELLQRQSQPAYQLLPQVPSYLQALQLQPPRIIMYGQAPQLQQAYQAMPMNSMQTCYMNTIPSATTSTSATTSTSATATTITSATTSTSATATTIPSATTSTSATATTITSATTSTSATATTITSATTSTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6F7</accession>
    <name>A0ABM1A6F7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 13 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106012661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941715.1">
        <property type="nucleotide sequence ID" value="XM_013086261.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012661"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045946259" evidence="8">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012941715.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12517" checksum="AFB19F32460BEB92" modified="2025-10-08" version="1">MHVHPLYLMLPTTAACSLAFMLPVATPPNALVFAYGDVKVTDMIKCGFILNMLGVAVISLGINTWGHAAFSLDSFPTWAQGLILQDPNATLSDVLTTTTVPDFVGNWTVSGNISTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6V8</accession>
    <name>A0ABM1A6V8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 628</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101860275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941989.1">
        <property type="nucleotide sequence ID" value="XM_013086535.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860275"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012941989.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="52489" checksum="980D0ACC38FB4F92" modified="2025-10-08" version="1">MMTSPTISPHAIYSRCPAPLVSPAPSPPVASAMYSPYILGTSYMSSPDFRAGGIPYFLPSLLNAYTMSGLTHHLPGHWAAAAAAAGHVHNVSDQHGSKESTLTPGHAYWPLSRAMSSSPCGQLSAPASAAVSTPETPLMIRSPSASKRGTSPDLRQTPKRRFDFSRLAESATSDLEASQSPDTPVSSSSQAQIFSHVMGPLENFRVLQENFRISQAIANGGKLGSSFSRNLLSGADKTKIRRPRRAKKEFICKYCCRHFSKSYNLLIHERTHTDERPYPCEICGKAFRRQDHLRDHRYIHSKEKPFKCEVCGKGFCQSRTLAVHKATHGPAHAKPTVTTEKRSPANHVMQPVSRIGGAAAEQQQHHHHHSVPQGLGVFTPIQPSHHGSSLRNLEQVVQRSLDVLPGNVSSRLYSVDRLLGRTGEDLSLKPHCTLPTQSATSTPPSHVNVVKIEDNQASNEEVEDDDDDEAGVEIDVDGDCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A725</accession>
    <name>A0ABM1A725_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012769 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942123.1">
        <property type="nucleotide sequence ID" value="XM_013086669.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012769"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="48"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942123.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26796" checksum="B5E4AF499F269BC9" modified="2025-10-08" version="1">MAVARIQQFRWWVVPPKFLGQGTADILLQCAKVLWDFSRVNHVLKKSDVMVVLGNDDPRSAVHAAELFLEGWAPFVVITGKEGTGTRGKLHKTEAEMFCDIMTSRGVPRDKIVLEMEATNTGENMRFSQNLLKTKGVQPSSVIIVTKSLMELRVALTFAKQWREAQKVQLVVSSPPLTLTEYPSPDVGSLDQVVQYLVDTFKKLTLYAELGHQAPVTIPVHVQRAYHLLANQLTGLETSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8C5</accession>
    <name>A0ABM1A8C5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyhomeotic-proximal chromatin protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942775.1">
        <property type="nucleotide sequence ID" value="XM_013087321.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854746"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01025">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942775.1"/>
        </source>
    </evidence>
    <sequence length="1097" mass="118717" checksum="29ACEDECC5697BD6" modified="2025-10-08" version="1">MESDDQYGPALPPGMVVASERASSSAEGKSSKKSSKNVIGPSLAPGMQKSSDSDDLSDEGALTVKMDPEMSPEYTIQDDQEEADDKNNSETVGPMPSEMTQEVGVTQVSEEFERRSKRMKDQLTVKKYRLRPRLQAEAEEGPSKREEWMTELPPDMSKNFGLQNRTFSKGAGAPEDKDRSSWTDTPTVKKEKDGSSKGKKRKREEEKAASGRDQQLQQQVDEYNKSKRPDSLMDMHAKKQKKKKGSAAAPVTSTPADSTQPAPAATATTSTVTPVTQPPNGQVPGQPQPQQAPGQPQPPQATAQQQQHMQQYFQLSDEIRESLDLLTEQKNQEQFYSQEFAAGEFNEAKPLADLLMNSNMVTYNQDGTATFSQAGQAQTPFSSSQMIAQAYSHAQQLSVSTPAFSQVVSTNSFPAQSLPAQVAGNMNVTVVNSSQAQDAATAAAVAAAQQQQQQQQQQQTHQATAQTIEVNGQQIQTQQATAQPQIQAAQQVHGYSEAYAAQVTGDAAVAQQQQQQHQQGQVVTFSLAGGQNMIIASPHTQQAGQNYVIAQQGAAPGQNIVIAAPGQQAMSGNFIVKTEGEELGQNIVLTQNLQQALGQNVLLTQDGQIATAAPTENMVLATADGQRAQTITATRQIQPAPQPQPQQQQVLTQAGIPLQAGGAQIPQVSLVLPPVNSLFPQIQSAGAPQAATAAATTATVSPQAFLQLCAKMDKMMGLVKDSQTVLFEMNKRVERIETHLFPQPTAMTQATPNKSNKNKPRPVVPASSTPQPAGGASTNTQVTKASLKAALSNYLTISDYTATDELKRSDSNSDLFIPVGTVSMVQGQAMIEAPSPSETPETASSTVAELPTEQDLLPVVLNNMGQPVANASVPTSDINVPIVDSQSGIAVTVYDEGNENQKFELGPGSSKEPNARFSNTSGSPKTVILDPRFWDILVEDFQKNMSSDQIISAMSSTRKPLVRSIGTSEISICSTVLKEAESACQGRRERLAKELVFRIFTLGEVYDRNVSGVFYINGKKMENKNKALDPAKMAAIHYLVMKYPPSVVDNPRLERLVWKNCVDRINDALRRIYNWIHKIVDVNNIMDKLPTDSIMMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8E8</accession>
    <name>A0ABM1A8E8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012943</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942810.1">
        <property type="nucleotide sequence ID" value="XM_013087356.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012943"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942810.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11228" checksum="D100922E9E7182A5" modified="2025-10-08" version="1">MNGTHGLPNGSGSSLPNGRPPVVPTVQLPAHQHTHHTPASRESSVGPAGSDTSESSVDSSGNAQLKPRKLFRIRSRAGEMTFGKLLMSPIFVNPEQAGYVGFANLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9E5</accession>
    <name>A0ABM1A9E5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cationic amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101847370</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginine(in) = L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:32143"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(in) = L-lysine(out)</text>
            <dbReference type="Rhea" id="RHEA:70935"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-ornithine(in) = L-ornithine(out)</text>
            <dbReference type="Rhea" id="RHEA:71199"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943345.1">
        <property type="nucleotide sequence ID" value="XM_013087891.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847370"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004755">
        <property type="entry name" value="Cat_AA_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00906">
        <property type="entry name" value="2A0303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF105">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="14">
        <location>
            <begin position="524"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012943345.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="67472" checksum="B55F3809CF37E1F0" modified="2025-10-08" version="1">MACSVFLKKLIRKKVLSNSDIEESELNRCLTTIDLIGLGIGSTLGAGLYVVAGQVARESAGPAVTISFLVAALASALAGMCYAEFAARIPRAGSAYVYSYVTVGELMAFVIGWNLVLEYVIGTASVARGWSAYFDSLIDKKIAHFFNRTMPMHVDQLSDYPDFFAFGITIVLTVLLAVGVKESTRFNNVFTCVNLLVVLYVTICGFFKIDFNNWELKDVPASAGSGGFMPFGFSGIMEGAATCFYAFVGFDCVATTGEETRNPQRAIPIGIIVSLIIIFFSYFSVSAVITLMCPYYLLDTDAPLPTVFEYVGWGLARYIITAGAVCGLSTSLLGGMFPLPRILYAMGSDGLIFRFMGKVSDRFKTPVIGTIISGIFAGTMAMMFNLKELVDMMSIGTLLAYTLVAISVLILRYEADVNLLGSMSVTKMDDASRAAVIREPFSVVRLFRPGSDQPTRLSALISKLATAILCVCVTGFSAFTIFASDDLGEVKTWAIAVAVALGLMMCFCVAVIFLQPQSSASLAFKVPLVPFLPAISALVNIYLMLKLSLMTWLRFGIWMLIGFSIYFFYGVSNSSEGKVSASSSSAMLFRKSSEADSDSTTTTTTSFSEDALLVKNETLPKYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA29</accession>
    <name>A0ABM1AA29_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apolipoprotein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943722.2">
        <property type="nucleotide sequence ID" value="XM_013088268.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863933"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045153743" evidence="1">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943722.2"/>
        </source>
    </evidence>
    <sequence length="102" mass="11612" checksum="6CC888E754167102" modified="2025-10-08" version="1">MCSLVLYLVVLVVLVIECSAFLVFSPGVCPSVPSMLTFDLKNFLGRWYIYETFDVPFQYGISLSLLEGRQPNYRVVSTDYTSYAVIYSCTRPTVLPFRMGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB64</accession>
    <name>A0ABM1AB64_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DIS3-like exonuclease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944356.1">
        <property type="nucleotide sequence ID" value="XM_013088902.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845656"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944356.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57584" checksum="C0922FA4264BD978" modified="2025-10-08" version="1">MDVEDQPFTEECLPTDLPWSIPASEMSYRRDFRRECVFTIDPATARDLDDAVSIEDLGNGMFEVGVHIADVSFFVKEDTALDESAGSRATSVYLVQKVRGGQVSLSSYLIFDEWYGRSVIRSCVKLSYDHAQGFIDQPEKEWSRDELPAITNTFGVEDVKKRVLQLNKIAVSLRKQRFDNGALRLDQVKLQYVLDGESGLPKGYFVYEQRDSNRLIEEFMLLANMAVAHKIKSSFPELAILRRHPPPQTKPLAALEELCGSLDLKISTASAGQLHRSLMKYYGDDELAKARLQVLVNMVSKPMQHAKYFCAGCIADESLYHHYALNVPLYTHFTSPIRRYPDIMVHRLLAAALGYCPPPARIKELFQKQAELCNDKKQNAKMCSDRSSEMYFSIFVKEAGPLEEMGMVMGVLDKSFDVLILRLGVTKRVYLDKLPLMKSKFRKNKKCPELLIEWAADESCDHRTRHLITVFTVVDCYIYAENTPLMWSCVIRRPKAEIKRVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABC7</accession>
    <name>A0ABM1ABC7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Prolyl 4-hydroxylase subunit alpha-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101848472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_012944443.1">
        <property type="nucleotide sequence ID" value="XM_013088989.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848472"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="179"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012944443.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36016" checksum="9A1B2EA6B6AD299D" modified="2025-10-08" version="1">MGRVSLFGGDVARAEQMYHESRDLDPRAGDVLQLKKELSTKPRVDAGRPADYFHNFSRLCSLENKHHSPVFNHPRIVCRYRPGLLPYYRVKEEILSESPFASVVYDVITDEENYFLRTHVKNKLIRGRVGGADAWVSEVRTSDIAWIWDSDSPIAQSLSLRVQAITGLDVKQRVPGGPSSSEAFQVVNYGLGGHYEVHMDPFDKPSDRPELQGSGERIATFLIYLSDVQRGGSTVFTRAGVSVAPVKNMALLWYNFTPALKRDDLTEHAGCPVLIGQKWIANKWIWTYGNTFRRRCGLTPDATHLDIEPDMYRRYGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACE8</accession>
    <name>A0ABM1ACE8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100533292</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945039.1">
        <property type="nucleotide sequence ID" value="XM_013089585.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100533292"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="13">
        <location>
            <begin position="141"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="149"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012945039.1"/>
        </source>
    </evidence>
    <sequence length="629" mass="70009" checksum="14055AE5881B4583" modified="2025-10-08" version="1">MGEGESAFGLVQAALTVDGLSVIEAAVAGMLENNSDIFRWIFRRGELYNLNRTKGIPCTTTPPTPWMFGPSLMDMIKQRKPKGLSGNLTFDDNGFRRDYSLGVFSMALDEGVQQIASSCVLVISSIIKQQLMTSSYRFSRHLVLTQTEPFLMKAERKDGEPVLMGNKRFKGFAMDLATDLAAEVGFTFLFRVVKDGSYGSQLPGNHSWNGMMGELIRKEAELAVAPLTITADRERYVDFSKPFMEIGATIMIKKPQSTRPGVFSFMEPLSVEVWVCIIVAYLIVSIALFLVSRFSPLEWRKVKEEGDSSYHNDFSLYNSFWFSMGALMFQGSDTCPRSVSGRIIGGAWWFFVLIIISSYTANLAAFLTIERMISPIESADDLLNHPTMKYGAVISGSTLQFFLKSDVPVYKQMGGYMMSNKEVLVKSNDEGVQRVLDSKGKYAFIAESSVVDYVNNRMPCDTTSVGGALNNKGYGVATSRNSELRDPINVAVLKLKEEGRLYTLHQEWWVEKGQCGGAHGGKQKVKLSLTLSNVAGIFYILIVGLVLAIIQGVFEFMCFRAKHKSEDTVTGDGYLKGTSTQSTLCNTPNDREDGMLPYELHPTQNSSDNNAGYIGFEKFYVDRGQRYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACY9</accession>
    <name>A0ABM1ACY9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translocon-associated protein subunit beta</fullName>
            <shortName evidence="11">TRAP-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Signal sequence receptor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101850050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAP-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945320.2">
        <property type="nucleotide sequence ID" value="XM_013089866.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850050"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008856">
        <property type="entry name" value="TRAP_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016400">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046293007" description="Translocon-associated protein subunit beta" evidence="13">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012945320.2"/>
        </source>
    </evidence>
    <sequence length="189" mass="21321" checksum="49C6898EE70CCD52" modified="2025-10-08" version="1">MKLWVSALLLTVGCFLPSFGEEESEARLLVSKNILNQYLVEGKDLTVDYKIFNVGSRVAFDVRLKDSSFPESSFSTVSGNLQVSWERIAPNSNVSHAVILRPLKSGYFNFTSAELSYLLSEDATERTVGYTSFPGEGGIVPEREFDRRFSPHVLDWLVFAFMTLPSLGIPFLLWYSSKSRYDPAKAKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD59</accession>
    <name>A0ABM1AD59_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106013663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945438.1">
        <property type="nucleotide sequence ID" value="XM_013089984.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013663"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046019661" evidence="2">
        <location>
            <begin position="27"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945438.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52922" checksum="1A78F55F374C6FC8" modified="2025-10-08" version="1">MGAAMMSGYILLATTVFLSSRALVLTTTTDEVAVGRTTNVSLECTDNYPLPDISEVILVRIRKKDLSGWTTIAELRDDLTKVSPERNDLLAEGKISKSFLRLTWPVATNDTVGWYRCDTVSLTAQAGVSWQKSLPTSISRKREVTLQMLSQMVEENKEEYLQRLRSQRQSIMEDVTATAAYNKRDWLQHTGHILHNVSAKLEALEARVQSQWESQLQVLSHTVEQKTRQCPDQPLSQIRQILEHVAAIMDHDKQEFLQQKEDILDNVTATVEQSIQEFLQQKDDILESIKETFEQEKRTFLQQKDDILESTTATQKEIQQQKEEILENAAATVESSIREFLQQKDNILASISATFEKDRKTFLQQKEDILESVTATQREFQQQKDNILESIKETFGQERRTFLQQKEDILESATATQRKCLQQKDDILENVTAKVQALEESVESKTNTIKNQIKVRTFQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADC0</accession>
    <name>A0ABM1ADC0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106013683</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945516.1">
        <property type="nucleotide sequence ID" value="XM_013090062.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013683"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF2">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945516.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39217" checksum="1F59FA2D0BFFBB07" modified="2025-10-08" version="1">MKGLAVLAKLSRGRWFTARLIYHLIGTCLAIALLVCFLLSFIPTRNFLLGGVFPGTWMPIPTSRLLRFHMAPHEYDVGNCPETCTRKYRPKTRLEDLKGRKVAHYDHLHFKASADYPPRSPIWDFLPLMSRQEKLSQLHLLDVLAEVLDHFNLGWFLVDGTLLGVVRHRGIIPWDDDVDVALSGKDWRKVKDVLCCVEGYTLVPRNFMHWKFFQNSSLLIRNAPEIRFPFVDMFLYAEDEEYIWSITEYNIQNLAFRKQDVFPLSRAPLEGKDYPVPGRSEYVVRTQFQGLDTCVSPGMLHKYNHALTQAEKSALPCSRLRHMYPVYTSLDTTKTDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADL2</accession>
    <name>A0ABM1ADL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA-binding protein Ikaros</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106013720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945650.1">
        <property type="nucleotide sequence ID" value="XM_013090196.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013720"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="558"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012945650.1"/>
        </source>
    </evidence>
    <sequence length="690" mass="73235" checksum="609563DD466577A5" modified="2025-10-08" version="1">MAIPTSQPPHSVGIPSQPPQPISPEEQEAHRLRISKHEPIQNIIGRHPHSDILYLICRLCRQTYGSPYGFRKHFRNQHGFEPKEEHTIVQTISATKTARAHTIPLDQLDSKVLSSLAIKEERASTEELSGESGNVKSSSGWPHSAGSTDTPPGDSEQGEVVKKSLSEDTKYLECVECGETFQLNDFGSYKRHCRQHSMNRSSGPFACHDCKKSFSEPAHLQEHLDTHSTFTASVCGICHTFFSSPNYLAEHLQAAHGHVYIPSDKTASEGDSIDLKVENSGGGHSETSADGQDKGVGVVKTGAVVSLSSSSSSMVVVTSAVTSLSQLQASNISSSPSPATSSSSPSMYAPLPLSKRHRMSQSSLKTPLFTVHTPKGLEVQKLPADAVVTTASPDSSYDEARFNLDSQPGSSTGGGSGTKSSTAATPDANNASSDSDMVRDSVWGGDGGKSHCTDDVRMDIGNVILNLPKQPEDGGLGKSGNRDDTESNSSERCASVDSNSLSMEGSRASSPRGEDAEKYYKHKKYSRHRKRLSSSEVGSEPETKLRKGDVGTPPATPPTTTSATSSRVDQSVTSSVTCSVTLGDCESSSCSHSECPDKSQVTDSSSTGSEDGKGGKGQVGDGVAEKSSKSGNTTTTSNVNTAKEEDKKGADFSKNSSQSDSSDGGAKFKWERLTRSQAGKTSQPVSYNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE62</accession>
    <name>A0ABM1AE62_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat-containing protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101863230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945972.1">
        <property type="nucleotide sequence ID" value="XM_013090518.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863230"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44464">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44464:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="454"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="497"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="540"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012945972.1"/>
        </source>
    </evidence>
    <sequence length="1190" mass="131009" checksum="9868E2A694B664AF" modified="2025-10-08" version="1">KPVLCIDWCHNGRECLGLVNKQGPLWLWHIEDSKHLSLVKETQNFSSAITLFRWHHQRHNQIAFGHEDGSVSILEIDFKKLPGSKAAKHLFRPEAVSESVEDTDPVVALEWDPLSTDYLLVCNHRAGVRLLDVPTQTTIMDFQLPSAASRVQTMSWVKNAPGMFLTGDYKGGILRVWSVSNSTPIENIKIKGTGFHRLEVIHPPANSNSSNNNSNSHSSSQGSLDDKDNHHVSSTSEARSPAMTTLSHFTLPHSHVVCAFNDGGIGLYDLGRKKWVFLRDQGHIETIFDCKFKPDNPDLLATASFDGSIKVWDITSMTCLLSSPGNEGIIYQISWAPSDLDCIVASTARTGVFVWDTTKGKVITRLNNHVAKTSVFSVSWNQADSRRIMTCGMDSYCVIQQVDGTVLQKYKHPAAVYGGDWSPFNKDMLATACEDKCVRVFYMASHSDQPIKVFSGHSAKVFRVRWNPLKEGVLASGSDDGTIRVWDYTRDQCTCTLQGHTAPVRGLTWNSEVASLLVSGSWDSSIRVWDTRDGACLYSLLDHGADVYGLTSHPARPFLLVSSSRDSTVRLWSTTSLVQPVELAMLADRPWTEAKVSGEPSNSSTTSLSLVGKVSVQLQSTHSLKGARSPKTIEAFSRFFSHPCGTNNLWDLVGAVGGSDTMMLSPAYPHGIVHRKHITQFKGSEAQQQEMIKMSKFGAGIGAPGKEERLMGAAATHIRLGNVQRYCELMVEVGKWERALAVAPAVSMKYWQQLNQRYSTALLREDSDDAVPFCVAAGDVPGLASFFTARGQLNDAVLVTQAACEGSISAPKVKGDSKERRHQRNNSSGAVFDSLAVEAMETLADFHFRNGSPTLAACCHLAVDDQKKAMSKLIRGHELELALSVGRVLGGATEETDVVLELLSRRCETLGKWDLGLDLLRLQRSPALTQALLCARCSSSMAEIDALLHKAGLPSMSSCEEKAKSLEASGCDVFDCVKLYLLSPVPERGLQLGLRALRGKLQSPNYTADDVVPMLRLLGCIKTEKLQHSKQTESMHELLALSAYFGGLVAIKRKYFPVVLPLFEHARSVISRNSLQLAISDKQIEADARIFFAMLENRLTEDLRPQYQALLTRCGSDTEWVVEAGEDCVASSHLPSHSDVHTSYLSNQRIKGQPYFLEDGRSCVSLNEALMWAKVNPFSPLASGVRINPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEX2</accession>
    <name>A0ABM1AEX2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106013963</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106013963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946363.1">
        <property type="nucleotide sequence ID" value="XM_013090909.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013963"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012946363.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26383" checksum="65C4F28901B865C1" modified="2025-10-08" version="1">MPARSCCSGNSSLVQKKPRASLSKRLRKRFKSQRKSHNQLFIVGALGLPSIRTSEGRFKTPVNMTSLSAYLSGNSPVVEMKEPRATLRNKLLKLFFRKKPQACAFVQNTTSMPKVKYVDISYESTTELAALGLHDQAFLEDSDASSSEIWDLSSLEQLDPTSTESPAGSEAVYMVMNPVDPFKKTFNKNNAVYNFRNPAGQLNKTFIIKSAEGSEAVYEEMNPVRKLNTTFTISPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF19</accession>
    <name>A0ABM1AF19_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adenosine receptor A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106013999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946435.1">
        <property type="nucleotide sequence ID" value="XM_013090981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013999"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012946435.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37623" checksum="9F6A9E70EFB7E755" modified="2025-10-08" version="1">MSMFVFEVPLYKHCRHPGPSILNAMSAEMLAPYTWDSEAPPSSYCWTAVVAQRNEVLGLAVADLCSLVTMLWISICMNPLLYFSELPFHLGDIVHLTGSTPHVLSVKISSFITAFITFERCLCITVPLKVKTIITPGRTKIIIVSIYLIVFILFIPFYFGHRFEWVFDFTRNATILRSTYTADREMLEAITFLALGVFATTFSFVFVICCTIVLVVKLNSKTKWRQATVAKSDRAADGVGVKDRKVVKMVTLIAVIFIVCAVPPTLLFFYMAIDPSFRFNSVYKNLYLIFWTSSFLTETVNSSVNIFVYLKMSSKYRAVFMKTFWNKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF36</accession>
    <name>A0ABM1AF36_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein amalgam</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106014014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946459.1">
        <property type="nucleotide sequence ID" value="XM_013091005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014014"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046136291" evidence="5">
        <location>
            <begin position="29"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="31"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="151"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="243"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012946459.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43253" checksum="26A161EE9D31E042" modified="2025-10-08" version="1">MAGTLGLSCTSGIFVVALLQLYVSLVSGQKPEIVNNIYPDVQRVGGTARLNCTVARLGQNSVQWSFKGKQGDEVISINERIQVINIRKGSIPNYEVIRKTDSSADRTTFMLVINRLLPDFTGEYVCTIMVTNDQFTMWTSKSAFLQVQYAPVIHPGSTDTVKQIHRGHNASITCDAMGVPTPNITWVRSDGKLLPNGNAIYRGRTLPIKVADVKFSGVYRCVADNQIKPPAESLTQVYVYQAPVVRVVQDSVGQYANGMLDAKLDCIVQGYPQPTVYWGYYKGDTFVKALDQDKYETTKQATDYQNLYNGEQWYTLLIRFVQAGDFRDYLCVAENSEGRGQRKVTLFSTYDCQGPLCYSIDPENRGGGALPRLSPVLLALWLLTTLCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFT2</accession>
    <name>A0ABM1AFT2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101849901</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101849901</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946796.1">
        <property type="nucleotide sequence ID" value="XM_013091342.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012946797.1">
        <property type="nucleotide sequence ID" value="XM_013091343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849901"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946796.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946797.1"/>
        </source>
    </evidence>
    <sequence length="980" mass="109348" checksum="0F166D0CC6FBB9B5" modified="2025-10-08" version="1">MHASRSSSNRSHRFLTSRWGGVRFPSSESTVSSDRPSCIYPKVRSRSTSNRQWSFSPSTVRVRPRTAIGQLENINRVAQMPGEMPVPTWKAQEGPALSTGDRAKGFFEDGARSPPRKVEDWKRSLEYDVSPTSQQKVRITKSECPPVPTSGNSPAFDGDGCTAMGEQIRHHNVPQAECCASEAGEGVGKLPQSLTNNVDIPRVTPETRPGLACQQHAPSHIPITPANTLVSPQFSVLSMATLLLQTPPLLLPKRRVLSDVTGVQSCLLDQESTRKHHAPIRHARSCSHYRKQSPPASGYEVEAKLHNCELHTGLGQAPQIFTDSGHLNRSPCIAVTSSDPGFNNIIRRPENNTAGAVTSPDPSRKKKCPRADHKIHKSIHPESPRQQSGTSKHRKGRGSSHKSASVRLAKAAQKTGASGCVKSPAKVRVKKRRSHWSARPARGTDSGATLSPEEFYNPLMSTRQHQNSPWSLSPIQCNDLPKQQQQQQRQQQSEHQLSLLQQQQKQFQDLLQQQQLCQKKYQEQQLLQQQHFVKQLLERLGQMTLPTQAALSHDAQTQREAERGEFNCDKGAEKNKEQSSNKLRSIGLGCNVHNDKMGNDVYRSTKKSNIDQRKIVNTNVDSRNSVNSIGSPENTDQDNRVPSNNAHRKNVRIITDHSYGGRSITNHHYNGQGYGKRRENSPEPASINIYRQFSPEMVDRRREVCCNPSRVSEPDVEQSSSIRECLSPASCQPLNVHTLQALMKPLMTNHRRQQQLQQEAIDRPDPLAISEEGIVDQLASLQSGVAGVAGDYPQLQYYKEQEQLQQEKVLRLLLQQQQQQQHYHEQRQQQHRLQQQRQKQPAVGAYGSVAVGVRDEAATGMGDDSKTGVKDNVTPDGHQQTTDASTSGTQGDFQRYSSPLVKLFRDQDDYLRKLKEVRERFEMSIRALSKERRCVSSGPTASPAVSRPPNCQESGSADSVWQARSVSKDTEVTKVAPRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPG1</accession>
    <name>A0ABM1VPG1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Synaptic vesicle 2-related protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106011104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824303.1">
        <property type="nucleotide sequence ID" value="XM_035968410.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011104"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035824303.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15224" checksum="76386A5391EFBE1D" modified="2025-10-08" version="1">MVLMAKLRRKTTLAILLLGYTIAMLLCNICMPRNALVVLLFVARGMSNGASQGAFVYTTEVYPTSVRAIGIGWNTSMTRVGVIITPFIAQMMIRTSAYIPITTYAVLGFIGCIAVVLLPIETAKRKMTVRYITISILLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPX8</accession>
    <name>A0ABM1VPX8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Ribosome-binding protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101860485</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824469.1">
        <property type="nucleotide sequence ID" value="XM_035968576.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824470.1">
        <property type="nucleotide sequence ID" value="XM_035968577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860485"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040248">
        <property type="entry name" value="RRBP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18939">
        <property type="entry name" value="RIBOSOME BINDING PROTEIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18939:SF4">
        <property type="entry name" value="RIBOSOME-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035824469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035824470.1"/>
        </source>
    </evidence>
    <sequence length="1084" mass="122468" checksum="F10B36C7FBC2DCAA" modified="2025-10-08" version="1">MEIITILIGVAVFIISALMIYCISAFSMREKTFEEVMEEQKRRQEEEREKAKAEKKAEKEQHKKKYKKGKQEKVKEKSAQVTEPELKVEHKVKMVNLEIEPEIIERTESLGLNAGLRQRGKRDKSSKSILHNKDEIAPVADKTVEMRHKQVAPKDELELKKAHEKVVVEKIEKVKAVQQQQEVKESRQKHSMESKENLPPKKNEETLKQPKGTPKGTPVKQNIAEQDKRSNKIKSDDVQLNGSQLISSVKTAKLSDEELQALIEILLNRQGLAPSSPVNQAESWNKKSQKGDPMSLLKRQLEEKERALQEEQNLAMSANSKVKELRNELGTEKTKYTALEKRFQEKVSHQQAELDALQQRMQHTHEQHLMETNGLQARLRQVEQGGGGGGGDQAAVQKLSAENKILQETLSLKAKENVSLNEKVKNFEKDLNNSNAKLLASETARKSAETKVSTSEEKIRKLEGGQKGADAMINKRVEEVAIQLRKSESRNDSLSSDLQNATSALSTAEAEVSTLKGKLQELETHLSRADASKEVESKLQESERKRSDLEGNVKNLEKQLADLSRRLSESETEMLRLQQENRSLVDENKTISERVQAAPAANGDIHEQNGPSLSMEEHERIVKEKSEEVTALTANLEGQKKATANLQVQVDTQTAQVSELQQQLAQQKAKNNELREKNWKAMEALEKAEKSSAEKADKALKSAREMSSAGSVEIETNDKAVFQRLFPEVKVSDKLAHKEWVVAFEKQALKKLQSSVNEDSYKTLEEENKKFQLQITKYEAQSTELNSKSARLQEAEKELSQLKSKKSSQVDSAAYSQIENDNERLKEEVEQYRSIVSETENKLKQLEKSIDAEEKKWKEKLKAAESSSSKNSGSVQRIAELEKIIADQEKQMQEYRNVLSLTENSLKQLESKVATEENAWQGKVNSSQSQLVQTQEELTNLKKQLLDSRGSEELPEGSMQTKVETLEEELRESQEKIIVLTSEKETVITKVMELEKTTTSGSSDKEVEELRSQVQVERKKNKDLSLNVVKLNGIIKTGQDALSQEQELVKKLQEQLDYKSVKSGVSESEEIEQAASSTDNGTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQN9</accession>
    <name>A0ABM1VQN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824731.1">
        <property type="nucleotide sequence ID" value="XM_035968838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477419"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="2"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824731.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37617" checksum="0EB9B00DAAB364EE" modified="2025-10-08" version="1">MIIGFKGRWANKQFNASKPHKYHIKTFGLCDSLTGYVYNLLLYYGKDTSYDPECDTKSLQAEKVFQTLLTNIGKGHTIFADRYYTALPVVDYLSSRGLYFTGTLQVTRKGVPQELKTRKLEHKETRWYMGDDNKILCVAWRDKKAKKPCVLVSTNANAEMKTVRANGGEASKPAMVVEYNQAMNGFDAADQNISYYGVHECRSKKWWKKIIFWLLEITQVNAHILYTLAHPNDKRVELRKFKSTLVEEMEFNITLNNNVDPAKSVSCERFVTSKMPLIHYDGRDGNCVACSGPGGGRKRTVFVCSGRSDRPFLHPKNCFYKYHTHRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRS6</accession>
    <name>A0ABM1VRS6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101849533</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101849533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825118.1">
        <property type="nucleotide sequence ID" value="XM_035969225.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849533"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="257"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="806"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035825118.1"/>
        </source>
    </evidence>
    <sequence length="962" mass="104004" checksum="2DEFD9245DC09867" modified="2025-10-08" version="1">MGKIDEFSFITPGQRKVYRPGDIVKGSVSFEVRSEDITVRGVHIYLCGATLTKWSQGKTQVQSKEIYCNIYDTLFGNDPGDGGNHKLTQGEHTYDYSFRLPSDGLPSSFQGSYGATRYWLRAVIVQPFPRINKTFYKSLTVLANVPVRTVGNLRSISEKSEKTISKALGFGDAGRVSLTVALDRSAYCPGESMLIDLTASNQSSKDMGSVKVGVYVVGSFSFLSFFFLFSFLVCFCRCWRKTFSATISFLPALGFGDAGRVSLTVALDRSAYCPGESMLIDLTASNQSSKDMGSVKASLVQHVYFKANDSAQSTEYPIRTIVSDKIQAGKIVFWTKKPFKVDAMPPSSKPLTCHIIKVRYDLEVKVEVPFGFDLEVSLPVTIATLPFHSEATGVVSGGKKANDLGYVECTDGVRSFRDSDGMFENFPFTPYTAYVNNYTAQVGTNQSLVKKTTPSGGKTGAVGITGTAVAAGGAASGGTAAGAASNAQTIKGKNMQATGNSGPSAAEKGQNGASSAAIGQNIGARASGSAVKATSTDETLLKRLNSHQNSQSSHSAAPPTTSVNRTVPTANENSSGRVNVAVPQDEPPTYEEATGTTSSPAAAPVKRSGKGAILLVGFPEKTAEKVKSFFLSSDSKNIASHGGQILCVCVRPFSRAEGLLPWPMKTAVVMLYFPSQRKAEAWWETAKTNSPEITQDLIVMVAEDMSGQKPSPDPRNTMNAVIIQRRVLKMDDTLKALYTEYQKKILPTIKGRLVVTRVISQTLKFLQGDWSSLENKDLSAKYTRRAEEESAAIYKEESPVKAEAAFSSSSSPAVPSSATHASSSPPSSPSSPSLPASPLPKSSEETCPKKEQASSETTLEEKDEISVEEKDESCVEERDENSEKKKDESNVKEKAEDTAEAKAADYLDEPVFRLVYSQYRDVNDYFSDLSEIVGDAELMAWNEKLKKYYALMFSLACPTKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VS22</accession>
    <name>A0ABM1VS22_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor IIIB 50 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101846501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825214.1">
        <property type="nucleotide sequence ID" value="XM_035969321.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846501"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054078">
        <property type="entry name" value="BRF2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21886">
        <property type="entry name" value="BRF2-like_C_cyclin_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRF2-like C-terminal" evidence="6">
        <location>
            <begin position="296"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035825214.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="55904" checksum="5A036FA022ED9939" modified="2025-10-08" version="1">MSLEVCSFCGEAAVIEDSIDGGGTQKICIECGSVADRQNKETNNVDSQESPLCLETVVCESCGEDLEFGAQSRICSECAPFEKDSSMRNEEEQNQAVFVPPESDPTAAQVVKLSCKSCGGSNLHYNVIGVEEKLVCQDCGSVVESIELTHDSFDMTTRSYGNGTQTLPWFSERSKKRAGLVAGQSKIQDLVKKFALPSELKDEAGEMFEQMYFQKEFLMATVFLKEHLAVACLFVVARRHDYPMSLTHFAKHVRKFKTLLVAKKRLIKVLGIPVSPASFTKQIGLCLAGKGFDNGVVSKVRDVMFLCRKAWLTQGRSREGLITIATYYAYISSPQCEKFIHMKPFRKKFSLPSASLELNRECNAFFLKLAKRLPWVDSESVKLHNLHQYVEDILKYQNSLLHLAFRSVSDDKSPSVLNDSPQKRPSGSEKEVLVPLCMKKPRIEIPPYTDVKVPPGVDLDSTELMDNEFDGEIEKYILSAEEQEAIGPLKALNWDRKTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT80</accession>
    <name>A0ABM1VT80_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Intersectin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101857218</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825622.1">
        <property type="nucleotide sequence ID" value="XM_035969729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857218"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08375">
        <property type="entry name" value="C2_Intersectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11837">
        <property type="entry name" value="SH3_Intersectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11839">
        <property type="entry name" value="SH3_Intersectin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11840">
        <property type="entry name" value="SH3_Intersectin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16652">
        <property type="entry name" value="PH_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="EH" evidence="12">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="12">
        <location>
            <begin position="210"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="758"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="879"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="967"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1518"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1622"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="1700"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="2033"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="638"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="943"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1211"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1388"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1461"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1586"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1687"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="943"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1338"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1601"/>
            <end position="1614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035825622.1"/>
        </source>
    </evidence>
    <sequence length="2178" mass="236217" checksum="F159FCCA98A73EF3" modified="2025-10-08" version="1">MAGSQDAWRVTGEDRAKHDDQFYTLKPVNGFVTGTQARDFFMQSGLATNILGQIWTLADMNGDGKMDRKEFSIAMHLIKKKLQGYELPKVLPASLKADPTPMMGSFAQPGMGGPMSPAMGMGFHMGGVPAPMGGGMGMPVVSMMQPQASLGTGTMTTGSLGMGPRMANGTAGGIQQVPGAMPVAGVAPTGVPGAPVAGQGGSKWAMPHNTKLKHTQTFNANDRNKRGYLLGVEARAILMQSGLPQQVLAQIWTLADIDRDGKLTCDEFCIAMHLSELGRMGITLPPTLPPELLPSKSRSGSVTSPPPASAQPTTPKKDAFTDLLGNAGMPQPVAPIPANAQPAEDLSIDDQVTFEDKRKENFDKGQAELERRRALLREQQKKEENERLEKERQEAEKRERQRLEAETRRQAEFQRQLEKQREKEREIEEQRRKMLEQREAARRELERQRQMEWERQRKEQLIAEKQREYEQLSILKSQMAKLKNELESLDAKKAELSLKITQVQGGVTDFTTSIDGMRVSRDRTLADIDLYERQSMELNKKSSGLNSEKDVLNVQVQTAQGTPLSDAHRTVMHSVDTKRTRIQQLNKEVEQLESDTEARLGEIDCNNAELKNMQEQISKLERDLPLLRKQQEEKITLQKKAAQEMQQKQKQERERQEKLKQEIEQQQRAKAAPAAAPAPAPAAAPAPAPAAAPAPAPASNADANWFDFNSSDAVSSAGGGTTSSSVNWDSAFSGTTTTAGSSIAWGSTNGSVASTGSQSKTKCKAIYDFTATREDELTLVAGMEVWVLNESEPVVGMEDWHRGESNGSVGWFPKAYVEKVEEPSGNVFGSAFEPVVQSSTSQKVETDLFSSSQFTQSSAISDSTSTASASPSSGTQIPPEGLLAKATYPWKARQEADLTFDKDDIILVKEQQDMKWYGELNEKSGWFPKAYVKLIGVASKSGLSAESSTPTQTKVPEPASVSPAPDTQGEYYIAMYTYTSDEPSDLTFSEGDMIFVTAASGDWWSGTIAEQGRSGIFPANYVKKLDIQLQPDKAPPNSTNSDSLFGDFGGNDPFGSDILSSASNQLDDPFAGAGLDPMGDPFASVSGTASSTNDMFSAVASPTSPMDDMFGSTTASAISPVDNLFASADPAPTSSSSSAFGSDLLSGFGDMSGAFGSTGSASLSTETKPTQSVSSAILSDGSDTTVSTATPMSENVSNLLSNLTLAKSEESSVTAVKSENPPDILGTTASGTELPAEEGGGEDRFAALSGLDWGDLGVDNSNDKPQGGLLDAIAPSPTTAASGVKKDEASGGVDAFSTSEDLFGGGDPFGKGGSALSNDDPFGKEMTTAVLEGFGATAEKENVHDNAPSDKPAPAPEGSDPFAGVLSAPVSQGDLKGSGVLGGVDFGLFDGLDQGTSQEKSSSKNDDLFSLDLVASPTSAKPPQSTSSLPDLVALEQDALQNNSLEIKLKDGIITKDNPALSSAAMESMTTQVDSGMGRTRSGSRRAPPPPVASAGTAPSAPDKNAGVSLNPEQKSTKKPEIARVIAPYVATGTGQLSLETGNLINVRQKSPRGWWEGELQVRGQKKKIGWFPANYVKLLGSASARSTPEPTAAGGLMVGSQGSRSATPQSIASQDGMQGINQQETVVALYAYTAQNDDELTFQKDAVITVLSRDNPDWWSGQLDGQTGVFPSNYVTPNPQSQSWMNDNVQEELSKLERKRQRVIQELISTEESYNSDMLIALEVFKKPLISGNVMPKEQVNQIFVNWEELIVCNKKLLQALRVRKKMCGKNGVIFIIGDILCESLPHMNPYMRFCSCQLSAAAALQRAAENSTAFQEFHKLCMQNPKVKGVHLSGYLLKPMQRITRYPLLIEKILSNTPTEHADRNNVEEALNLAQELCNQANQCVKEKQNSDSLEWIQSHVHCDGLAENIVFNSTTNCLGQRRLIFHGILYKAKSNKELIGFLFNDFLMLATTSRPLGTTFSTVHLFDTSTQFKMYRVPIFLNEVTVKKPVDDTDPTLFHITSDRIINLKAVSHVERDTWIREIEAASKQYKDKAKRKLERAHSVKRPSVGRILVVIQEACHLKASDQSGKSDPYCEVSMGSQEHRTKVIPGTLNPRWNASMQFLLRDVERDTLCFTVYDRDLYSPNDFLGRTEVRIKDVLDQSGDRRGPITKRLILHEVETGEVVVKLDLQLYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUD3</accession>
    <name>A0ABM1VUD3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-5AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826025.1">
        <property type="nucleotide sequence ID" value="XM_035970132.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851192"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="824"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="920"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="965"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826025.1"/>
        </source>
    </evidence>
    <sequence length="1021" mass="104203" checksum="A3EAB0E957C5B24C" modified="2025-10-08" version="1">MKNVHVAGAMMDSFPGHGSSSSSSSSSSSSSSLPLPRAGSSSSHSVLAKVLGIQIKGETEMTVRNVISSSQSHSLPHSYSHSQSHSPSHPQSHTQSHPQHHSQSHSQSHTQTHSQSYSQPHVQHHHHSLPLNAPPVSGGKSTHHPPTSCLNVPRTILESHTHRILHSASPGVRPMPIAASHAQEIRSVISGPSTPQTAVVISPLQVHRRPVVCGGSGGKGGGGGISSDGNGSSDGNVCTTPHTPDTPGSTIGVRRNSTPSPTIRTLAGPSVTGHSSTPTTPAPSTSVSGCTNTETSSNNSATTPASSSNSSSDAEMLKRNQLLDGSALPDASSSNTRSSASSVPCAPAICAVGSPGHPQVATSVVGSTTGHLQVGTSALGSTGHPQVGSCSTGINVVSCLPVAVLSDSSTSSDLLHGDNEPRTCSVGAASAASGINITNPGKRPLSLPASFSSSMIINPTWPHSGPGVLTSRVTSSPVRSDTSSDTSCLGVSRVDNSTPVVSTLLTGPINKAEHNACIERAEPREANKDITVQASRLDAAGHVISALSMSAASVCDQSSAVSCTIDTQAEGCGSGDGSVSSKVPPEGCGSDGSAVSSKVPPERCGSDGSAVSSNVPPEGCGSDGSAVISNVPPEGCGSDGSAMSSKVPPEGSTLTSEVTPSELLSHVSPHDSDVQLPQPSTAFTNRSRAYQSDNGILSPTSVVRKRNDQVPSLSCTGYRDDPLTTGPAAESLTIECGFDADGARVSSQRTDVGPVVNNEQKDCLQHGGVGRSHSEDKTNTSDGSATAAAAADATVSHDHLPSLTEQNCVTTETVGCSDRAPVLGDGFSNSKSRSSGLLSSSGDTRLQSPFQTEDDAFCLPSADETDLNNSAVDGSMSTPPVLTAWVDTDVLDPTVSEADSSSRESQDKEKTCHEVSQGLTSQCTSQVTTTTSCQNSSRKEKGTVTDKTTSVYSNLPSSSKKDLSKSSPVVVTSSTVMERRTQADKGETTSTSSSSSGAHGSSPTTVTTRRRAHYVHEYLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUT0</accession>
    <name>A0ABM1VUT0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101857577 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826172.1">
        <property type="nucleotide sequence ID" value="XM_035970279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857577"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045586057" evidence="3">
        <location>
            <begin position="23"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826172.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="54776" checksum="432DA6BFE6DC16C7" modified="2025-10-08" version="1">MYLHTHYIRSMLLCVVISVSLSLPISSSVSANVRAWSPANTQHVSPDKKSLWLGDMKLVHPTTIKNLNFRRQYKGYDTKCHVRFKQCTIDLRNLVGLFPCLFEILKNSPVFKSNIAMITVDQISAALPPVCFHSVIFYNLCLCRTRGEVLPTSVLNSLCKNREFIPTKFHSKEVSRQFSKSSPNVVQMKSPASFDKFVSLRTRGIEDCLKSGFIKPKKISRCLSFFQKALHASYFPKRKNLFQQYVRMLQILCSVAEKCRQSLPYSGVDTPAQSLHGQSPENSDDGQSPSSYHGVSTPSSAIDDHSTQNSGDGSTMTHLANRRHIRRKRSKSHDHDGTDKGQSDVDSSGKSTANSSEQLLFSNYTWDSEFNKANFKKIMEHREFQRQLWMEGVFSRQKDAQWAYLCLVFLICLMLLSIWCLRGFHNRNTNKREFTLHDTYHLLTVKEVLWRKARYLPMIHREDNLEEVFVHDCGNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVK4</accession>
    <name>A0ABM1VVK4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850422</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826446.1">
        <property type="nucleotide sequence ID" value="XM_035970553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850422"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF73">
        <property type="entry name" value="FI21235P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826446.1"/>
        </source>
    </evidence>
    <sequence length="657" mass="76175" checksum="5C389D3F056F7FE9" modified="2025-10-08" version="1">MFEQKKWNFCSIKVIFGLFCLWTVAFLMFFARHRHIKMADVSLRSDRLSPTTQAAFRDNPSLEQQGGVLPRQECIHPQLKVNDPVMMKFFRKYPPLTCSGQKDWIYVDNGTVRFSKPLHGKKNNFTCDYYPLVRVGDYEYKWGLPHVDIKDGFPMTSDFFRAVCKRGTREQYENIHAGVSYSKQRTERPRDPLKSGFEGLSIAILGFDSMSRMSWLRRLPNTRKYFHDELGAIELEAHNIVGDGTTAVMFPMLTGKFEWELPECRVNFKGATTLDKFPFIWHDMKKAGYLTSWANAAPKSAPFNWRMLGFKDQPTDFYPRPFYLAATPTFKRFTSHCLGSQTQSKVWLNWFRDIFLMYRQQRKFLFHFITDMSHDDNNLMTQMDDDIRDVVKFLHDGGYLNQTVLILMGDHGARYNKVRSTWSGKQEERLPYFSFLFPPWFERKYPDAMRNLRTNTKRLTTPFDLHETFKDFLKFSGAGKGNVLARGISLFKEIPLERSCEHADIAPHWCACLAWKNVPVGDKDVVKALGTALLTINGFTKEYRSYCALLAVANVTMATKLETRAEVLKFKKTDSNGGIYAIDMSDKNKNEMALYQLTFITTPGGGHFEVTVTQDVIKGSFDLTEKEISRINKYGDDPACILDKNRQIRQYCYCSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWP4</accession>
    <name>A0ABM1VWP4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118477135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826836.1">
        <property type="nucleotide sequence ID" value="XM_035970943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477135"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826836.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15277" checksum="13254591A7D6AAC1" modified="2025-10-08" version="1">MDSDAGAEKSVSFMSIRNTYKYIETYLGASKTAKHRQSVDLERMFFGKHDSSEKSEDGNSGSGTDDEKDKGDGSDDDAGEKRSTGGKSTDSEVSRSGVHSANSNEDSKSWSTVDVSLAHANLYYLFLFIFVYSDTNYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWV3</accession>
    <name>A0ABM1VWV3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478063</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826895.1">
        <property type="nucleotide sequence ID" value="XM_035971002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478063"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826895.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13508" checksum="7C4BFF6B4837835F" modified="2025-10-08" version="1">MAQARIILKALRVKRILNRLARAKENTIRAMVGLPPLMSWYERCCMGVSAGVRECLCRAFCPCCIGRPTFGELCCPKHSCGYKLCTPGQYPNELIKSFLGFLFGLALSVGVYFFMCLQVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX14</accession>
    <name>A0ABM1VX14_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101847276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035826956.1">
        <property type="nucleotide sequence ID" value="XM_035971063.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847276"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043588">
        <property type="entry name" value="SSH-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23040">
        <property type="entry name" value="PH_SSH1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="12">
        <location>
            <begin position="264"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="323"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="385"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="729"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="882"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="958"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1391"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1478"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1631"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="826"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="902"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="974"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1442"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1508"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1540"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1571"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1631"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1741"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1760"/>
            <end position="1769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035826956.1"/>
        </source>
    </evidence>
    <sequence length="1769" mass="191783" checksum="9ACAB3D8BC24E56B" modified="2025-10-08" version="1">MALVTIQRSPSPSTDPDLETADSSEDVSDGRSQIRKRSKTPREKLRKIFSTVRFISKLRPCLSESYFTVKGAALILPHNECNKKSVKKTHGGELQSHLQAMLHLLRPEDKIKIAVRLEDTVPTYHRYLAVVSTNGKQDTEEAVVLGMGCSGTEADIGLVMPVWMGLRLQLGGDGGFSLCMDELAYLFKPVSVQAMWSAIQHLVKVMHVAEDRKYIHDGLTHTWVGYYRSRIDHRDTAKTCQWNNEGVDTYAPSSLSINSDDENEQIKRVISQKLKEVMMTVDLDEATSIGLRKAVEAKMGISLTSLKSYFDEEVMRILGQMDEPSKILDFLYLGSEWNACNLEELKGKGIGYILNVTREIDNFFMGMFQYYNVRLYDVEESDLLKHWDKTYKFIAKARDHNSKVLVHCKMGISRSASTVMAYLMKENRWGVDEAYQFVKSRRSCVRPNEGFMEQLHMYEAILTASNKRDIFRCQSDQNLLDEPGKEEMDTSQGSFLGDSLFHVMSHSEWPTAAGSGAHEEEWMHQLHTGSVPNSDLMHIEADVETESRSADSIEEALPDMPSPPPTNQREVILTSADQSLSATLSSSSPPTGATVGLMEGGDRACGGLSFVDTAEGNMWLKQEGIDDAAYLSMQGGGGMSNAALGPSRIRPDSSWIRLDAVEDETSTDGPPKISEDGEEQTLPSGESSVACEILDDAMAPFGDGSASGGHGRVDADGRGLLFLQDATVTDSSDFSEDAKNKPDAHCEVTQTPTNLSPSSLHSAQVGQPSAFTKYVAEDSQHQQQQRRAEPSPRDASQLDPSAKIAGATKGGFLNTCQSLPHLQQATPISSVPPATSSAPHQLPAGRVARDKLPLGVTMSSSSSLSSHRPQFADPVLCGAGEEAVSKSGTHSPGEEEAGLATESDKPLLRKEGDKGEPLAEPPAGKIPLSKVELGVRQYFFREKIPWNPGRVRKMREEINTTGQIWGEDAEKGSPGSGEGSEEGSSGGGNGWLCPAGSEVSSDQALLEQLAEQPALTPLSQSQSCMELYVLPPAAEGEESCPLSLYQKEEIPLEPGTVLRTRLEIEERQRLFCGESDQEIFGTTRPVVRTASLKRDSESPRPRYCEQRRMTCGPIMSPLSGKSLDDLRPVGSADDNDISNFSFPVFRGFPGQAETTEGGERKTAEQMRESSCGQVLATSKEPDTTVPDQWSSMAGASESTIIEPGLVKKQTQELEQKCDLERSVTCAVPEGLSADQTMDGQHMAETTDTPRAIKGNFDDETLALIREIGSALLMSPTPQKSAQEDNEEEEDSCSNMVRYFVRKIEKQAKPSPVESSGSNALVDICGQKPSEIPSKEDALRLAQQRAVSTIGVAVSAHLSGQCAEHSGGFRMQDMSCGEGAFRSVGHVAMGDQASGTEGGFPISPGRSAVAGDEGRKLGAATTSPQSPGSGLHLPLDRMDEESLSSVSLTSSPMVSRAGHSSSEEPSVVRHLVGRFEIKSPDRMTPDFGQDYSLKHRDSAMDSSPCRGSPESQSDSSKTTSLYPTSDGSQFGSATGDLAGTESKSNKLFSTPMETGGEVPLHFQQSKFPGTSPPMSSVPPSVALGTSPLSVSSHMARQKHRTPEAQHTLRSAGAATKSSLAFDIAVELYELGDTPKTEGDAMTAEKIDDSDVALRQPVPTPFSKDGLMALEKKSWRPVRPQSGGGGHHSQRHSVSEGQFDPMGSLHGSSGDKRSGGQQLELYESPHGLEVDTTLRQVSDEGRKIRRLHGKSHPLTKLSQKRVGGGPFHSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXP2</accession>
    <name>A0ABM1VXP2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tryptophan 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827185.1">
        <property type="nucleotide sequence ID" value="XM_035971292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846671"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138:SF0">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827185.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29995" checksum="BFBA7D405A643473" modified="2025-10-08" version="1">MSLSPAYELWFKQILHEIDSVREMFMLPVLDETKTLLILNRLSRVVLILKLMVDQIDILETMTPLDFLEFRQKKRRIKIRLVSVQSSRVKYNQEHYAKVFSDADKVKELQASINEPSLFQLVEKWLERTPGLTVKSFQFWELYKRSVGVWLQDMILAPAQVRHPFLRFTKLLSAHDRYKVFLDLFNMSTYLIPRAYIPPLSRSLRRQLSILIHEHTPRDSSDEDLEEETAAAARAAKDGGKGGDVDGPEFGKVKFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXS4</accession>
    <name>A0ABM1VXS4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase fray2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827217.1">
        <property type="nucleotide sequence ID" value="XM_035971324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849631"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827217.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40523" checksum="99201E35BA367261" modified="2025-10-08" version="1">MKLSVPGTSGWQVRNITLHKTGETLQMMKCFDLLSVLLVATLFASVAPAVLSRDNVLTALGLSKEKGDISWETRLDQGVVQSTDDGDDDEDSNDDDLAILDALRQIVSEKEEDELLEQLENQLANLDGETDSGEDVLPKHRTARSTRSRTSARTSSSKTRQRSRARSRTRSRDRRRDRSRSTDSASDRTRDTGRERTRDRTRGRVRGRARSRSPLRERLHSRSELRDRIRGRPGVVSRQGMRIRDTQGVTNVLDTATNGVLSENINGRLTQQYHKNGNFLTAVQDFNSLNPSNIADNTNLVSGIFHRIGTLPDGRTVIVRNGSSGQDLPTLEIRDYTDSSRRNEYYVKVRYHSRGSNTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYF8</accession>
    <name>A0ABM1VYF8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dedicator of cytokinesis protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101858958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827451.1">
        <property type="nucleotide sequence ID" value="XM_035971558.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858958"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08697">
        <property type="entry name" value="C2_Dock-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037809">
        <property type="entry name" value="C2_Dock-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF26">
        <property type="entry name" value="ZIZIMIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="169"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="646"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1697"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1311"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1424"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1237"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1323"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035827451.1"/>
        </source>
    </evidence>
    <sequence length="2148" mass="243205" checksum="A514BDAC0AAC41C6" modified="2025-10-08" version="1">MSGPMSERKFAEGLQRKGNAAKIRETVSQALRESAIQSRPKLVEPVDYETFVVKNKVLLHNDPQLEMLNFPHDDVLVPPPAPPRRMRTSVSTVPASTDQEVSSLMVKECLKTYTSPLQTVKFKYQPYAGSYQQLPNVSKKEPLQEHIFEIDAEVEEKDDDTLSRGFVSTITKRGWLFKGPDSGKDNIISFTRQFKRRFFFLKQQSDYSYILEMFKDDKKSDCKGAIFMDLAQEVVKNPKKGKHCFEVRMTDRPPCLLAAENESEANDWILTLNKVINAADTASQASRDSIREENASSGTPENYKESSINHPVVKYCRETDSSLAKARQEARQNLFSIYPDMRRSAFDEDAEEEEEPEIEVFPRPYAQRFLLQLKELRFGLQFNLADEGKENKKCNPEPFFLTFAIYDAREGKKISEDFSMDPNDPEVRSMIPADLLSASDRLHSVSGQENSMPDLANLSEGWLSQSARQGIFSIARPLQDVYLVARIEKVLQGGITQCVEPYVKGGDSKMALKVHRQMKQFCSHIGHYRMPFAWSARPLPSTSYGTLDLPIYKQEGSKFSEEEMVKVLQDFRKPDKGSKLQVIPGSLKISFDLISADSEPIKNTLTSSLVPVKPFSEPAAGSVPVVEVEEFVPDVASLSSCFDSYKNNLYVRPVSLKYDSQKAFAKARNIACCIELRDSDEEGAMPLKRIYSKPGLSPFTSVASTTVLHHAQTPDFMEEVKLCLPVQLKEKHHLLFRFYHVSCEGSKASGKAASGKKKDSIEMCVGYAWMPLLHEGRVVTGERVIPVASSIPLMYLNYDTLSSSKSAGSEVKWVDGGKPLFRLRLHLVSTVYTQDQHLHNFFVHCQRVESGGGLAIDMNNVNKIKLENGGGGCSPPGDGLLTPPNDLQSLLNGVKSLLAVEVATYVQFLPTLLNQLFQLCARTVSEDVAVNSVRVLIHMVSLVHDEGKCDYLEKYVKYMFRPDPAVKTSKSQRTVHEELSKHLTSLLRPANADPLVVTRFLKHAWFFFEVLLKSMTLYLIDTDRIKMPRNECFSPECQYRLQNLLHMVTLHVIQKNKERKEETKNANNSLAHFVKKCFTLMDRGYVFRLVSKYIENFNPGDSKALHDFKFEFLRIVCSHEHFIPLSLPLMRRGMVKNFKEIKLEDLKHDYCLSDEYRKLHYLVGLLLFELRQAMTEQRAIRRSAITVLRNQMAKHSFDDRYASRTQQGRIAALYLPLIGLLLDSKNQLLQIGPSPKAMNTPTPTQNGDVNYRSDVTKSTISLSKGQSSPAVGGTPELKKKDSSVFAMISGAVAVPHNPNELTVAAFSASGQKGSNTSLASDSSSDKEAGKKDGKIITRMPSGASSTPAYVSRLDKLDTTEIRDLLLCFLYILKHLPEDILLGWFNNSSENDIIDFFTVLELALKHFQYQGRKKIVTLSVIGSHKSSTMPTPLQNQRGRPASLSSQRAPSQYGDLMAEGIHTPHTSDADAMIRALQEANISTEVGLVVLDILSLFCTTFKKDLEARGGDNNMMHTVFRIYLSFLRSSQSETLQKHVFGAWRAFIKKFQAVLFKGSADMCGELCYEILRCCNSKLNSTRREACALLYLLMRSNFEFSNRKSFTRVHLQVIISVSQLIGVVVGLSTTRFQESLAIVNNYASSDKSIQRCIKFPGTQKTPFPGEVRDLTKRIRTVLMATAQMKENENDPELLVDLQYSLAKSYASTPELRKTWLDAMAKLHIRYGDFSEAGHCYIHIAALIAEYLKRRVNTRALGGLLGSYPQGCSSFGFISPNIVVEEAGIKDDSGMQDVQYTEETLVDFLEKGAECLEKAQRYEVLGDIYKLVIPIYEKLRDFQKLEKSYQYLSTAYGSVIDVMRSGKRLLGKYYMVALYGQTYFEDEKEYIYKEPKVTTLTEIRERLYKIFCEKYGRENVQMINDSKKMAPSELDPKFAYIQVVYVTPYFDDKELATRVTDFERNNNVRRFMYELPFTRSGKEHGSIEEQHKRRFIITTTHSFPYVKKRIEVQEGGRKEIVLTPIEVAIDEMQVKVSDLREVINNPVPDMKRLQLKLQGGVSAQVNAGPLAYAEAFLNPEKISKYPIDQSDRLKAVFREFVTTCKDALDLNAKLITTEQKEYHESLKQGFMEIAERLSILLGEKVVLLDLKTNRQDSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYR9</accession>
    <name>A0ABM1VYR9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18 19 20">Metalloreductase STEAP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 19 20 21 22 23" type="primary">LOC101848139</name>
    </gene>
    <organism evidence="17 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Cu(+) + NADP(+) + H(+) = 2 Cu(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71771"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:71773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(2+) + NADP(+) + H(+) = 2 Fe(3+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71767"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:71769"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the STEAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105642.1">
        <property type="nucleotide sequence ID" value="XM_005105585.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827561.1">
        <property type="nucleotide sequence ID" value="XM_035971668.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827562.1">
        <property type="nucleotide sequence ID" value="XM_035971669.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827563.1">
        <property type="nucleotide sequence ID" value="XM_035971670.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827564.1">
        <property type="nucleotide sequence ID" value="XM_035971671.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827565.1">
        <property type="nucleotide sequence ID" value="XM_035971672.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848139"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051267">
        <property type="entry name" value="STEAP_metalloreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239">
        <property type="entry name" value="DUDULIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239:SF0">
        <property type="entry name" value="F420-DEPENDENT NADP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="16">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="15">
        <location>
            <begin position="258"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005105642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035827561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035827562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035827563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035827564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035827565.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="60450" checksum="9CCBF2C4D3C572AF" modified="2025-10-08" version="1">MEESLVPLMENDTKSSGTNGDRVRIGVVGTGNFAVAFTKCLVMAGYNVIMGSRRPGLRKSTLPMTEECLCGVELTTISECFTNSDVIFIAIHMEDFQDTLGKYQELTRGKILVDVSNREYRYAAHSNAEYLTSILPHAIVVKAFNSVPTQALEQLSGMGREGLKVLVASDSQSGRTAVSEIAKSLGFLVIDLGGLKSARYMEEQVLKTFTLWRIPLFLTFGIFNLWSLFIVYLYFIEKTAYNWEQIFLKVLNKPLCMTAITVLALTYLPGQLAAVLQVINGTKHKRFPRVLDTWLKSRKQLGIISYALVCVHVIASVLMLSPTYYSSWFHHATVTLPANVSHATLDAEVVLPVTRTWMTWKGEAACLVGIAAFLLMSAVALTSIPSVGESLNWSEWTCVHSKLSYFVLFLSVAHVCVMGGPGWAKAGPYKIWKSITFLSSLLPMFVLVLKILFSLPPLSGYLRKIRRGWERDSRKAQSSPCSRNHDVTVVDIEDESQKEGSRLSKLCGCAHGKGSHNYKGVKGVSFANTNCHCASERLQTKTSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZK2</accession>
    <name>A0ABM1VZK2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101846377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_035827845.1">
        <property type="nucleotide sequence ID" value="XM_035971952.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846377"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF12">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="233"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035827845.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32560" checksum="E25377D2E7B978BF" modified="2025-10-08" version="1">MQGYAPTLIITALYLLFVWVVPKIMESREAIKLKYTLVIYNFVCVLINLHICTELFISSTALGYSYSCQPVSYTYDHYEMRIAKALWWFYFSKCVEMLDTVFFILRKKNNQVSFLHVYHHATMFPIWYIGVKWVAGGQSFFGAMINSFIHVIMYTYYGVAALGPEYQKYLWWKRYLTRLQLLQFFVGLVYASQSIYVECDYPVWMEWSGIVYGFTIIALFVNFYVQAYIKPKSSSPAAAHGKREQEDKRTKGGANGSSANGHVKNGNVKGLDEKEESKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZW8</accession>
    <name>A0ABM1VZW8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827961.1">
        <property type="nucleotide sequence ID" value="XM_035972068.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852875"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF9">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGAT4 conserved region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827961.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35983" checksum="B63A887B290868DD" modified="2025-10-08" version="1">MARRKIKQLLGLIGLLTLLPLWYQFSSLFTEXGQFVQRAQTINDQLHDQVEALLTSGRDNAHVDLAIPGGRRPAEERKSFSSLLYYPANDSRSNQTTILEPGAENNTLTGTPINQTSIREIPVELPGVYTYLPHTRGNPDALRPLVEVSKGRTDVQLVIGIPTIHRTVADYLEETLHSLISNLPPSDARQCLILVFVAEPWNVTRVNLTVARLQNKFPSEMSSGLLDVISPPPDFYPDLDRLKITLNDSKDRVKWRTKQNLDYAFLMLQAYQRGKYYIQLEDDVITKPDFYKFISRTVTSQQKEWALLKFSGLAFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W058</accession>
    <name>A0ABM1W058_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101861314</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828051.1">
        <property type="nucleotide sequence ID" value="XM_035972158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861314"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033207">
        <property type="entry name" value="CCP110"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13594">
        <property type="entry name" value="CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13594:SF1">
        <property type="entry name" value="CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16025">
        <property type="entry name" value="CaM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828051.1"/>
        </source>
    </evidence>
    <sequence length="1453" mass="157422" checksum="EB5FC324DA68D765" modified="2025-10-08" version="1">MEGTVVCLSKNVSAQLSVGVNVTLVKLMCGSPAGMGQLIKYFESQSRRLDRQSFHTGPSCFNSDFESQIKFNGVPILPPAMTSSRRDDVRQDKKDAVLLEKRLRARHRRQLMTQADTGVNDTSQMTYTDMNNRPTARQLNFDSAAQDGGLLSGTLKERLGATNPLSTFATAETDLAGEDFGLQTMDTLNSDFMSLEGGESIPTVFSGIKLNSSREQKISYDLDRLSKVLNVQELNSTSGSDVSEALANTGASEEDLRNAARWAEKVLAQKASASEGGGGGGDVQSASFFHESQDTVVEVSPEPGEGRDSESGGDNTVTTATSGFVDVNTNSTLEQSRTSTSVNSSPGCGSANTTDSQRSSRSSPKSLKNAVHFASFVTEYINTSASQSLESTTIVTKKMSAADQSLSKVSSDIGALASDGVLPIIGDPSEARLKQTQGKKVVQADGSAAGLLSRVSLNPDSDSSPCTPPFDPSSGMPFQYYGRTEAYSSDKENEGSVPHKGHHGHRGTHDHTGSRSRGHGHVSDGGEWARHGVRRRQSSEGDDETRHEASDQGSGRDGRKSHAPLTGHRSLPVVNPAVASAGVGAQDHQSFSGGSVVGANQSCQESADDLSAVKPPTGEVTTGKMSVSDSQGSNKSNTLTATSESSSSTIRDDMSARDNTALAMNIVETGCGQVNVLDNKAVDDNVSESQVGAEKTDVPNKKEEKAHSPKKLNVDPSSVEKESAAENDLTPTKVLVRRGSYTLSEPSPALVRARSRLEAQDKERVSKDVAATSDAKAEQKEEVAPYVDKDEEAALNRKLQFELSPDASAPQIGRNLVNAQVPSEAEREGKAEHINKYLSQVQLQNSMNISHQSWDVLHRSQGEGEEDEEEEEEEEGYPGLMEDGMTAVDVHNSILDMVKSLPESSQSLDLSVDQLTRLHQQRLEQAKEELIHRQEREMEELFVQQRRDTMLLAAEIKAAQQLEKEQQEFLIQNAPENLKVKARGQSGEFSPEHTGDFDSNVLEQRDGGRPHTGESGRRSEVEEAMNSLHNLRPQSYHRHSHADPAGSMPSIQLQPKSYPAGNLKTGRSVVAGKHGVGKKKSQSSVMNISGDSVGGNEAHQTRVKTLSSDDSFSPRVAPPRDAAGIGHAVPEFSPSPNSPRIHRPSVLRSPLKFPSSFRRDGKVVVPPQAHSAEMRVKFDRVSAVAKGFLTRCLLRSDKVQELVKTIRDTRTFAFDFQTETPIKKGVFTSQDRTLLERLVAQLQAALLDLHEIFFEIPTSERMALIEQTRAKEQEKRVRISKDSVRGSGPRISQATLKALERKRKAREAEASAMLSVSSSRPTTAPPATSSPRCQNHQDISGPLRRHFGFLISRALKPLQGHGQTQVSTSRTDTSRSEKERPRTAPEKQLTKPKRITAPSHPRPSVSSGQDSSKDAQKDGSSAKHSNTSSSKLVMKTKVAPSKASSSRPTKSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3R7</accession>
    <name>A0ABM1W3R7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding protein 39 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101855316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829310.1">
        <property type="nucleotide sequence ID" value="XM_035973417.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855316"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="156"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="254"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035829310.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="63404" checksum="B381937025DD7CCA" modified="2025-10-08" version="1">MADELDVEAMLEAPYKKEEEGKVERSSSSSKKEKKKKRSRSRERSKERKRSRSREKTSKVKDRRSKSRERSPKYRDRRSRSRSKDRRRREKERDRRRSRSRDRDHERRRRSRSPRRRRSRSAQRTDQPHADKERTDQPHADKGREPELTPEERDIRTVFCMQLSARIRPRDLEEFFSSVGKVRDVRLITDNKTRRSKGISYVEFADPESVPLALALAGQKLLGVPILVQPSQAEKNRAQPAVAPAPQKASEGPLRLYVGSLHFNITEDMLRGIFEPFGKIIDIKIMRDHETQRSLGFGFISFANADDAKKALDQLNGFELAGRPMKVGHVTERSSENGQGGGQGGQLDTDEMDRAGIDLGATGRLQLMAKLAEGTGFEIPPYAASALNSLTHASVTIGGTPVNPQTPQPLQAGVQSNIAAAPGAQPQAPATSVVTNAPPIATQCFMLSNMFEPLTETRTTWDQEIRDDVIDECNKHGGVLHIYVDKNSPQGNVYVKCPSISAAVASVNALHGRYFAGRVITAAYVPLPNYHNLFAESVRANQLLMPSSQALSASYQTGFMAQPPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAE0</accession>
    <name>A0ABM0JAE0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101849971</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101849971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089117.1">
        <property type="nucleotide sequence ID" value="XM_005089060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849971"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="56"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005089117.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32629" checksum="8DAEC3FB705126AF" modified="2025-10-08" version="1">MGASTVRDILYETCNVIWDELKATELPELTSDSFKFKEIAMGFAQRWNFPHVLGAIDSKHIKVKCPPNSGSTYFDNKQTFSIVLQGICDAQSNFIAFDVGDFGRHSDGGVLEHSAFGRAFYSNNLPIPPDESICGSDPLPYVFLGDEAHPLLRNMMRPFPRRGLDNVQRIYNYRHSRARRSIKCAFGIMAAKWSVLKTTLNMKPETAVKVVLSCCALHNFVRKRDEDENSDLIDDNDNSLFQMEADTSATIGRPGQQALDIRNEFAELFLFTLSVPWQFDRAQLVETDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAQ6</accession>
    <name>A0ABM0JAQ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101845204</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101845204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089359.2">
        <property type="nucleotide sequence ID" value="XM_005089302.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845204"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005089359.2"/>
        </source>
    </evidence>
    <sequence length="310" mass="35047" checksum="CE6EEF190368F5AD" modified="2025-10-08" version="1">MSEPRSLSLLGMNAETMRSTGLNRITSVFVPFTTRALLSGPPLRASSMYTACGPIDDDLWEAGQETPATSQVFRYQSVVGHHAKPVCSELYIHRRDHRNGKKRVVPTMLYNLEANRPPVPEHQLLEDDFRAFRSVAHNRQTVLQSRMTPDLQVEKFLQDNHLACTILGTTPNSSELLQLAKLVRSPGCRGDQMVTYRNSVADPLGYVYRRHARHAGKQEQQGPRVAEKGVMATDAQRVLPTVQIDESFQNMHVPLCARNPNAEEREIHRFCADAILVSDFPERMYVHNEPDAVPSHLTQEDFSKPLIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JB66</accession>
    <name>A0ABM0JB66_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrous sheath CABYR-binding protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089637.1">
        <property type="nucleotide sequence ID" value="XM_005089580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863942"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089637.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="40742" checksum="1468770A106EC309" modified="2025-10-08" version="1">MSEAETVNVEAQPEIMPSPKKEKQAANEENKENGNAPSEVKEQLSKESVESANGEQEKPTEPMPAESSESAPESAESTTKSTESAPESAESAPPAESAPESAESAPESAESAPESAESAPPAESAPPAESAPESAESTPESAESTPESAESAPESAESAPPAESAPPAESAPESAESAPGSAESAPGSAESAPGSAELAPGSAESAPPAESAPESAESAPESAESAPPAESAPESAESAPPAESAAPESADSAPPAESAPPAESAPESAESAPPADSAAPESAESAPPAESAAPESAESAPPAESAAPESAESAPPAESAPESAESAPPAESAPESAESAPPAESAPESSESAPPAESAPESSESAPPAESAPPAESAPESAESAPPAESAAPESAESAPPAESAPESAERTVESAPAEPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBD0</accession>
    <name>A0ABM0JBD0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005089757.1">
        <property type="nucleotide sequence ID" value="XM_005089700.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849976"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041400">
        <property type="entry name" value="PARP16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18084">
        <property type="entry name" value="ARTD15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="9">
        <location>
            <begin position="161"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005089757.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45943" checksum="2B9DE1373E3033C0" modified="2025-10-08" version="1">MEHSTAHDQNVEPDADKFPATGASSSVVEDPPNDVESSGDDFNFRKNDNDDNEEAMERKRRDVSQHPGESSSNGTNLGLPRMKLDIADLIRTDIYCCDLLWCLFVSAARSYRFSSVLRPFPPMYQEGDNKNMFALKNVISSVPQFSTTPQFLQDLPNECQTLLSWLFNVGHFKLQLREKDSAFKAVKEMTGQIMDTTEPNYVFEVVHTDEMDRKFENLRNGRKCFFAYHGSRFDNFYSILLNGLNTHLNKVSVFGEGTYLSSELSVSLMYSPAAESSRHSLLGSKLACVAVCQMIDDPSVKCQVKEGSVSKQKVRAQASKVTDLVPEKYYVVQRNDVLRVKYLLLYKEESSQIQTTANTSSSWIRDNKFTLLMVAYVLLLVAIGIANSRHAMIYLNKFWKNVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBH6</accession>
    <name>A0ABM0JBH6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005089838.1">
        <property type="nucleotide sequence ID" value="XM_005089781.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848329"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="75"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089838.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="60803" checksum="960734E0EB13B46F" modified="2025-10-08" version="1">MLCYFSVSGSLRLSMIMDGKLDKFISEVGGCGMFQVLLSLAVYTIKVVGAWGMLFMSFGSYNPGWTCMDLKVNDTVTALSEPPYLNSTTLGILGPNSSVSTYNMSMSEQEKCQEAQSCQDVRFDPDSATIVSEWYLICDRSWLAPITISIQMVGVTIGSFIAGQLAERFGRKLSMYLWVVLGVVSNVVALFSPNWEVYTAVRFVIGMSVGGNLSTCQVYALEFVTAKWRVFLTGLPTWNVGSISFGICVFLLKDWRDAHVATAVLGAFAFLSVFWVPESLRWLVVQGKVKETKKVANMFCRVNGRSEPDPHLTAFTNCEGQQDDKKVAIRQLFRSDLRKKTIVCSAIYFFMAIMYYSIGFGIKALYGDFYINFILYTVFPLPLAPLAPVLGHKLGRRWGSTVLMFSCGLVSSSVIVVFFTTSGQVQGYVITGLALATSALLDYAWSILTAFIAELFPTPVRLLSFGFIFSAARFGSILSPFLIPRDFSILYISYLVMGILAIINCCLILSMPETKDLGLEDTLHARSQLEVEMTQGDITKPTRENSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC97</accession>
    <name>A0ABM0JC97_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Gamma-interferon-inducible lysosomal thiol reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101846476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090370.1">
        <property type="nucleotide sequence ID" value="XM_005090313.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090371.1">
        <property type="nucleotide sequence ID" value="XM_005090314.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846476"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021066" evidence="6">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005090370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005090371.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25430" checksum="5A047AB1FF9D1630" modified="2025-10-08" version="1">MKYTVLMVLVTVAVSAQTRALHIPYPRETPMVDLMEATSIGAAPVNVTLYYEVLCGGCHDFITTTLVTAVKALGDDGSIMNFHFIPYGNSLETWNRTTSQWDFSCQHGPEECVGNTVDACVIHYKPKFKDHYRFIVCFEKNVDYKSQAWKEALEKCGKRYDMPVEEIASCVTTKLGNTLEHEMALRTGPHQWVPWLILNGVHTPQAGDNLLRAVCKAYKGPKPKGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCM9</accession>
    <name>A0ABM0JCM9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cystatin-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101847010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090622.1">
        <property type="nucleotide sequence ID" value="XM_005090565.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847010"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001713">
        <property type="entry name" value="Prot_inh_stefin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414:SF21">
        <property type="entry name" value="CYSTATIN 14A, TANDEM DUPLICATE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414">
        <property type="entry name" value="CYSTATIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00295">
        <property type="entry name" value="STEFINA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="6">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005090622.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11123" checksum="F984BEBD13B9DE00" modified="2025-10-08" version="1">METPRVLSPVEDATDETQMLIDSVYEDFMERCSKNYSMYKALQYKTEGTSFYFVKVQVEPDNYAHLKVFKPSGGSGPNKLSDFQLDKGLNDEIRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD79</accession>
    <name>A0ABM0JD79_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal acetylcholine receptor subunit non-alpha-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101854226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005091020.1">
        <property type="nucleotide sequence ID" value="XM_005090963.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854226"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="85"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005091020.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30995" checksum="95F72FA1F9567567" modified="2025-10-08" version="1">MDVTNFPFDEQKCTLTFLSMSYNDQQLKFVPLRKKVDVNSLTSHGEWNIVDASVDTENSPQVTNVSAIVITYRLQRRHVFLLLNTVLPIVFLSLLNIMVFLIPEESGEKISFGITVLLALALSMSMASSMLPRDSTSVSLLIIYIFVLLIISLLTVVLSIVVVLFYHLDERYANSIQEEERSFFMGFFCQALAKKVKSPVTSNQEKLEQPEQIQGKRMSKILDTDSLNDAEREVGTKYRSIGRIINNVSFVVFLCVWFLLTSFIFLKLTVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEC1</accession>
    <name>A0ABM0JEC1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Uncharacterized protein LOC101864126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101864126</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091773.1">
        <property type="nucleotide sequence ID" value="XM_005091716.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091774.1">
        <property type="nucleotide sequence ID" value="XM_005091717.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864126"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="595"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1387"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1447"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1397"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1451"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005091773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005091774.1"/>
        </source>
    </evidence>
    <sequence length="1491" mass="169153" checksum="C2035803D46FE8D3" modified="2025-10-08" version="1">MSSRKKQLSGDIHIPLCQKASCKAQLTELAAALRNKELTCVTDYRPFGKYSQWFQEAFQETTFTIIHKCPFLWRKMNTCLDLLKESSKIMAIDINPEHSSVDEKEDVDSSFVEFFEDLMTHEVKNKETLGAFLDMITPYLRDECDESEPASEPTENSSNPSGSTSVSGGDDIASMRVGDQEEEEEAEENRDGFKVHPDKFNCKIFSRVFMRSSSISFANHESYGYSEGPCMKMKNTIDGLKVKFAHDKAKILSNLQYILFKVLPDMYEKRMVAGLATLGTCDELSVQSRAQSMLELILFQDRGAVKGLDFSSLVRVESSLSSALQKLRASFAVSHNKGTQLTIQRLCTLYLMVHCEMIMISQDGGEMLSCNTHFSTVIGRPFVSTRNRNRADESLEVLDFFITETNKKSCNGVRARVAEFIKLDNPYQLAKELTRASLSTQTIVTFELLKKVFLKLDLNALSFLEEYVKPTSSTLFRKAKEVPMTCIVILLRGLTHLFSHGLKQAANQDIKLLCLKAMSVMNMASRRDLPNEVGRMMQTLLFDPKPAVRKGIIKFYSERNNYAEVQPIFLQNEVERILCPLLQFTPDRKLPSEKLTGQWTLFSGNFGTTEVLVLIHKPTQVVHMNDNHTRFRSQVDFHHNQMRRLKHLQHKNIVKMFSYQEHCIPQFYVVEDYLTTNFQTALKNRSDNRAFFPRSQLFKFLINACSALEYCHSKDFVHRNVIGSSFFMFGEEIKLCGFQLCVRIVEGQGKAVEQNNVGVPTRWTAPESLEKGEYTRESDVYMFGHLMYEVLTHGLMPYSHIQMSDSEIVPLIIDGNASLCREACIEKSSFKIIGECVQHAPCNRPDMSSLQSMLEDLYNWVSENPSEKIRQYPDLTKGTGRSSTQYKVGAMQHHRAEVRPSEARSFIVLTESRRVFRVNGRLVIQEVLSRSWPPEMKVKIETEVLSSVLPPIKLFKAQNGSELIEFSLPSGCIGNLQEVTVKRLLGKNSPRLYLYCIYQVAVLLENLYSISWVLGDLCASNVYVECLENDVKVHVGSLAHLVFLSQYEENELSEEMPRPTNPDVVARGAPEVNSSGLYSAAADVFNFGNFAWEVLTAYDHKDREEELLRVINDSSEYSSCYSQEPQAAACEHIAKGAWKGKHKKPESCSESFYELIKLCVSGAESNRPTVPHLKEQIKKYCLEQYQLPMEEVKDSSRGEPPETSPSIATLNSSMFELDEMNETVAGSSFMDSDSLYNLLDEEVVKSKNAVFRELIAKSSLVSPSPVFAEEAYMTPRYLNETIYGETTDTSDERIYEDIDQCVEDIGDQDTKNVSAKKLSLLEKKKKFKSFSKDYLALNYSSHGVMDDDSSPEEIYDDNCEIYLTAGEEKESKTAQAPEDDYHSDIFYENTEEQGGKIPPPPKASLPLPPVPTVKQPDKEQAQHFLKSPLPVEAARPFRFNVKKFIPFSKPTRPPPLPKCPPPLVPNPNSSAEPVIEDPSDQHEAEDLYEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF18</accession>
    <name>A0ABM0JF18_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Uncharacterized protein LOC101845830</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC101845830</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005092224.1">
        <property type="nucleotide sequence ID" value="XM_005092167.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005092225.1">
        <property type="nucleotide sequence ID" value="XM_005092168.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845830"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="28"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005092224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005092225.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="44819" checksum="FC827697F2985728" modified="2025-10-08" version="1">MAAQVDDEALSEARKGLVVIFIIGILASNIFLLFKFLRKGRLLQSQRKFLVMTLAGGDIFLALFSLVILARFSFKERFYISCKTTTVSSMYSESFLPFVYGVGIIVLCGELGFRKKLRSLISSPYVSSLLVAAIPWIAGLIFIVPLYLDGYDDLKCSYGGSMTFDRVRAIYVVSIVLPSALAVIFALMTSCKNVKTMSEYYNTSQLQGTVVSQTVVTYNAQGYPQQQYYPGPPQQQYYPGPPQQQYYPGPPQQQYYPGSPQQQNQPMPPPATAQQPYYPASQPPAYVSGPHDPGLKQPAYPPQPMPPSQAVIQTPVSSTQAASDQQLSAAVRNEQSTLVVVAVLYAVLTLPYALFQLGYTLNNDHIVLDPIPRTALSQLFLWMFYLRSIVTPIVWITREKTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGW9</accession>
    <name>A0ABM0JGW9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Uncharacterized protein LOC101860960</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC101860960</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005093414.1">
        <property type="nucleotide sequence ID" value="XM_005093357.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093415.1">
        <property type="nucleotide sequence ID" value="XM_005093358.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093416.1">
        <property type="nucleotide sequence ID" value="XM_005093359.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860960"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005093414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005093415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005093416.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="70026" checksum="C13AE08ED7645857" modified="2025-10-08" version="1">MSVVKVKKHLILEEKIQAIDMSEQGASHIAIAKYFDVSKTQISNLMKRKEEVRAIWNDGCVHQKKILKPSLRHPEVEEVVVKWLLQARKNGIHVKREFLQAKVIAVASEYGVPFSPSNGWIHSFKKRHHLYTGENLDESLFNDSTDMKVEREKDGDSSKDDETFNCSQHNITKNEQMLSGLRNTEGAKSTEKLPTGDLRKGLLKKRKRSSEPGSGLDKQHKSSEPGNGLDKQHKSSEPGNGLDKQHKSSEPGSGLDKQHKSTKIMARDLQHFAMGGAQAEGDERPAAFDVEDSYELENVFVCLGAGLFFKARPRPVYLQKKKQCADGRQADQRISMVLMCSGVGEKFSPLIVGRCQTLSLSPGLLPVKFMPEYAAHSKSWLTQSIFKNYLSRLNEKLSHEERHIVLLLHPGVPALGTSYSHIKTLPINSSSAGIFYTDIVHPLKVCYRKKFLRHLLSLKYQSVSTSDLAKQVTVLDAIVWLRSAWEGVSPSFISKAFLRCGLNGVQLEVTEGTEAPAQASAEEDGKALLPDGVSFNDFAKIDDHLTTFDPSEGEGREGESVVEAEEDVPQETEESQPSHVSWDRAMKCLEKVQLCAFQNSNPTLLHHVREAEYCLMSQRRETEGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHG9</accession>
    <name>A0ABM0JHG9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal acetylcholine receptor subunit alpha-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093755.1">
        <property type="nucleotide sequence ID" value="XM_005093698.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857864"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044996849" evidence="5">
        <location>
            <begin position="23"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="29"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="239"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005093755.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="50778" checksum="CDC35C9543FE8F90" modified="2025-10-08" version="1">MCVALRLVFYIGLISPSSLILASNYNDTARLYADILKPFDNRIRPVINQSEPITVYFQMFLLNILNIDELTQQVDLNAWINFSWVDELRTWDPSNYNGISSIHPMPLDTWRPRILVSNSVAKRDLFEDDYTPLYISSDGRSKWFPGTIFSISCDLDIRYYPFDSQTCTMSMMTQDFGTNVKLHPDPSTLMTGNFKRNGEWDLVSTRVTPSTILFPGASFSILTIDIILKRKPVFFVVNILVPIMFISAISSIVFILPEDSGERASFAITMLLSLSVFLSTVSNQLPQNSENFPIIISYLFSLLILSGTTVIATVLHLRYRQKKKESTPDSDGNDACYDGPVLSAGRKRHFHNASVQPAWGRGEKQLAAISDGDQSFQTQDFTQRKISLISNDDVALARETTTGHVKQANDSQVYSVVMAYLKDSNVLLFVFFNTAWLILTTYFLVELMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ93</accession>
    <name>A0ABM0JJ93_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101857321</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094906.2">
        <property type="nucleotide sequence ID" value="XM_005094849.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857321"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="972"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="893"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="972"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094906.2"/>
        </source>
    </evidence>
    <sequence length="1137" mass="125554" checksum="9862AF266BB7C549" modified="2025-10-08" version="1">MVIGWKDRLVGLEIKSRSPVYRWLGMRAVSRATSLPVLPQSVRLSETYSLFAFVLARLFNEVEHWQSRCGRSRLEEFSLSTLEGWGVFNKLRVQHQVEELELMYVQCVARFVETSHPKLHLSFPQRYSALLEEVRQKLLHNLTSRTLRTHLLELLLQVHNQGVPLMSHRTSGTDVATQTDGQAVNERDRDGHRADSRAAARVAEQTNEMATRGSVGFYRPPRGSLNPRADPFVPHVFPSEIEEGDSAQLLSPPDGAEYSGEVPVLPLDNVKSIVGHGGSHTCTALRDVDGAELENCLESSKSNNLPPLKESSSVGKIHHSSHHAIDRRRKFPKSLLQLPPRLLQKCMTDSHLFLKGAGTHNSHAANTSSGHAADFDNNGHAADRDSDRAVSGDSGRAAHSRSKVVHFRQREAETGSKSFSPPQELDFSNTAESEEMTTGQTNGGCSLARTEDGYRCLELQSGVGQCGDGSEGRLDSALLYHHNRKNSFDGKGNERDSSEDQEHLLDQSKDYHVLIRPDGDFTYSVSGNSDLKHDKFDSTSDPEHTLEAAGHVGPLDEVMGSDCTAAPIRGLSERVVQHPTLPSSGGEVDECSRGMLPGTLTIGETGQVSRSQYGLSYSGDSWPVSDDDQLELNRDQVKSGDGQVRTFDSGSRKNDCETKGDFNQLGPDNGPARKELAVRNSQTVCKDQAGQNSKEGVQESLRGRELCKKMHLAYTPDELRALNPFSGDGMGQARVLNEFRDRCMTFLKGLPNAHELPIREPPGWVSKASKPTARYGCSGEAPVALSTVLGSDWMNWKKLSDLLPESKLGQQKVSAPSVLPTVGSSVDPAPYSSSLHANRSYATVQSQSDDSFDFHLGNSPHSDHKSSSLLDRGKSPHSDHKNSPLLDRGNSPHSDHKSSSLLDRGKNPHSDHKNSPLLDRVSSPLLDRGNNPHSDLENNPHSEGNNCAAKLQSPTEVWHQPMWPQDFFSSTKTATAPISNPANGDRKNLTSTRSKKKKTKFRPLSDFEVRVVKDEVEHSEPVGRPVREGGDPYGFDDDDDCEGDEDEFSEEMLQMYIQLEEAEQKKDSGQVLHLPRLGGTCDGPPRTSLFAKLRQQEQEREQRAREPWAPGKRFCSKCGGEGHMMYDCPQWNQVTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJI7</accession>
    <name>A0ABM0JJI7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101846275</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005095117.1">
        <property type="nucleotide sequence ID" value="XM_005095060.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846275"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="224"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005095117.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="60222" checksum="DCA6CFF7C6BB8AAF" modified="2025-10-08" version="1">MSAQGDQVIGPDGKPISKKALKKQQKDAEKAAKKAEYKKQNTQEGAEQEVQTEDQSAGRYGNLPLNQSQERLDRRLYKVNELQPSISGQKIWVRGRLHTCRSKGKQCFFVIRQQKWTVQVFAMQNENISKQMIKFVSSVSAESIIDVEGTVQKTDQKIQSCTQQDVELSLSQIWVVSASEPRLPLLIEDASRPEGEGELATVNQDTRLDNRILDLRTTTSQSIFRLEAGVCRLFRDYLTEKGFVEIHTPKIISAASEGGANVFEVTYFKTKAYMAQSPQLYKQMAICAEFDKVFTVGAVFRAEDSNTHRHLTEFVGLDLEMAFNYHYHEVLEVIGEMFVNIFKGLQQNYAEEISLVGKQFPAEPFKFLEPSLVLNYKDGVEMLKKAGVEMEDDEDLSTPNEKLLGRLVKAKYDTDFFILDKFPLAVRPFYTMPDPHDNKWSNSYDMFMRGEEILSGAQRIHDPEFLTKRAKEHGVDIEHIKGYIDSFRYGAPPHAGGGIGLERVTMLYLGLDNIRKTSLFPRDPKRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM28</accession>
    <name>A0ABM0JM28_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101859097</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096870.1">
        <property type="nucleotide sequence ID" value="XM_005096813.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859097"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005096870.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="17306" checksum="453E0D582411D2CF" modified="2025-10-08" version="1">MESTTLLKIAGLLFGFIGFTVSAVGMGTGKWIDSILVEIGPFCSNTIGTAVEAVEAMTLMGEIMAGFGLCLGFVTILPGQNQITVGQTVLGPKATGGCFTIAGFIMYIGVIIWGTKVYSLLKVFGPLGYSFYLCCAGGSILLVGGLLFFLSARGSQLSPNQTRLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMG5</accession>
    <name>A0ABM0JMG5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101863811</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097139.1">
        <property type="nucleotide sequence ID" value="XM_005097082.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863811"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35313">
        <property type="entry name" value="NO EXINE FORMATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35313:SF1">
        <property type="entry name" value="NO EXINE FORMATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="812"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="870"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="941"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097139.1"/>
        </source>
    </evidence>
    <sequence length="987" mass="109021" checksum="A782BC0715010561" modified="2025-10-08" version="1">MMETFLEDAENSLHHRTNTGSNGSGSSDESDDPLDDPFLYDKFLPDPYWAKAEQLEQAKPKNLVDPGLFRYNKRVFVTSLPALLLVLALGGETLVLITAVGTAVITIMSQMGDSRRCVIFFIVMFIPTHAYILATVLPLLWLSMWHFFLVVLTNLFIILTAAWVLLQFKAFRMEETELACIVELLLFTLYPLACTSLVSWALGAVVSISLIPVIFSMMWFVLLQLYLVPTLSSFRSQTTAEENLDVIQVPVVVVTVVGFVLCGPLLHVMLAVFAVDTQPLFSVISLTHLAFILSLTCFLSTLLSVRQIFEYMGLPYTTAIYVRWVSGSLCTLLCYPVLHTYGLDSHFLPLLPVAIAMFAALGVVLAFKRRRMIMAVLALVLLSSLAALFLLWIQGMPHNLQHYFMGIFPLNVFYLMICINFFLCLLCLWTASIDNKSMLGFLLFVQSLMLTVCEVSLHNGQLYSTSLLQLTSVSAMYTLHRLHVAEKISGGAATMTSAIQCAKSMASCTSLVLDGGKGEISLLEMAALGCLAYAVLSVFVYHSTGEKTTAQMGKQLLLLLAAVAVNSHHLLLPLSLLMFQGYASYSNIIGLWCLLCGGLTLLYSQTTGSTVTAFIIIRVALLLSIMGVVIMLLHPQLSYSLLSIFQWAEILSSFALAVLVSHRPTMHPQGVFVCSILFAVCPGIRACLYLWSVFHPLTAGLCIVNSAALLMLFFICFLITEWTEATETMMKTSMVLAGSSSLCLLVLDVIGWLTARQSADTLWGPARTFCQQPAWIVVLLTCLAISLILKVVQATKGLSKLPLTHEEGSSRLSLPLLANIVTLVAFAVACTQGPREATLHDLWCCAATVIFGCLHKDSVILPRLDGDKQATPTIMASFSILVLATVLRSRFWDFAFYLSVIGGFFEVLMALVSIPIFYVMWGILWKGEVLSEPAVVFLTPYSFLLVMCATSYSAWLLALATLVSGMWMMMYRLPMVPYGVDYEDRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMR3</accession>
    <name>A0ABM0JMR3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101845918</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005097320.1">
        <property type="nucleotide sequence ID" value="XM_005097263.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845918"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF700">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="132"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="290"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005097320.1"/>
        </source>
    </evidence>
    <sequence length="615" mass="66871" checksum="5B2B5558C7FF2A49" modified="2025-10-08" version="1">MIGNEVVIEVTDRSRSKPSCNVLLSDFANMVKAFIGSNYLTIAFAFAQSGLVLGIVGLFLIALVTDHCCLLIVKCKYHAIRHVLDKHRMSSSSGSIVNSNKSRRLMSSEEEGEEREQQSVEESEEFQKIHKQLQRSMTYGDVGKIAYGSWGVFMVNFCLIFTQFGFCVNYFIFVGNTIFALFPTVNGSLPVNDTGMTSSMPLALAVDQDKDFSTQSFMSTPFLNGSVDFISSSLANFSNITNATTSAPTTTSTPTTTIATSATWAAMNTSTPSVIPLSDLFLDVSQAPDLRLLVITPLPIFAGFAFLRDVRHLGFVSVGADVSIFLGCVVTMGYILVGFSVSTTWQLFDWTNVAIFFGMVTSSYEGIGTVIPIESSMEGNRHNFSNFLHGSVFILTCILSLFGIVGYLRYGTGTEQMLNQNMPSGTPVSIAINVCLCVGVILTFPLQIYPVIELSEIFLFGDGRICGPKKKRKTHHVDDEDSESDGDVGPSEGGKGRDKEALLPKEKVNIPAPVAATVSDEVSTWKRNLLRVCLVVLAAGLAVVMRDFYAYVGSFVGALGSSLLAYILPCLFHLKLCWAQLHPGVKIKDILIVVFGLAASVVSLYSTIRSIADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNE4</accession>
    <name>A0ABM0JNE4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit g</fullName>
            <shortName evidence="10">ATPase subunit g</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101849844</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097772.1">
        <property type="nucleotide sequence ID" value="XM_005097715.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849844"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016702">
        <property type="entry name" value="ATP5MG_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12386">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017835">
        <property type="entry name" value="ATP-synth_g_mitoch_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005097772.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12214" checksum="BADD39ED5071D339" modified="2025-10-08" version="1">MAKVVAFFTRVGTNVVTSTRPKLATAWKYSKVELRPPSFSEIPEVQHGFQKLIASYRTGAYKQLTVREAWLNTLIGAEIFFWFVAGECIGKGGVIGYNIPGAVNWDMHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPN5</accession>
    <name>A0ABM0JPN5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Snaclec A11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098601.1">
        <property type="nucleotide sequence ID" value="XM_005098544.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864224"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046686230" evidence="1">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098601.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19824" checksum="9848AA132ACD79C4" modified="2025-10-08" version="1">MLSFSSALVVFLVLGLGNTKSIDDCPSGIPRNKFLQFRKGLCYEFAVTTYRYFWHAESNCLANGGLLVQIKSKDINDYIQKELHETYKEPYDTWIGLDDANPGEKFTWADGSSVNYENWAPNEGERFGGGLDACATIDPVNGTWIDYPCQGFLFEEVKPYVCEYDPDNLLTTPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPP5</accession>
    <name>A0ABM0JPP5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101848818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005098620.1">
        <property type="nucleotide sequence ID" value="XM_005098563.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848818"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01336">
        <property type="entry name" value="MDH_cytoplasmic_cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011274">
        <property type="entry name" value="Malate_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01758">
        <property type="entry name" value="MDH_euk_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="156"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005098620.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36041" checksum="9F405A1A764FE136" modified="2025-10-08" version="1">MAEPLRVVVTGAAGQIAYSLLFSVAKGDVFGKDQPLELLLLDITPMMEVLNGVVMELMDCAIPLVKNLVATDDPNVAFKDVDAAFMVGAMPRKEGMERKDLLKANVKIFKAQGQAMEKLAKKSVKVVVVGNPANTNACILSKYAPSIPKENFSCMTRLDQNRAQAQIAAKLNVSTEKVSNIIIWGNHSSTQFPDVAHAKAEVQGKVVTVPEAVQDDNFLKNEFIKTVQQRGAAVIKARKLSSAMSAAKAACDHMRDWFIGTKGGNWVSMGVISDGSYGIKEGLMYSFPVTIENKKITIVQGLSINEFAREKMDATAKELEQELSDALAECVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPV9</accession>
    <name>A0ABM0JPV9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">15-cis-phytoene synthase</fullName>
            <ecNumber evidence="2">2.5.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005098752.1">
        <property type="nucleotide sequence ID" value="XM_005098695.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860098"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098752.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37697" checksum="9F341837AEFEE439" modified="2025-10-08" version="1">MIGSCRPCISVNINTYARRRFNKLVEKHRSFFSGHHLLHTSASKSAPVQSQNKSNIEYCVDLVRKSDYENYLATLLLPKNVQRAAFALRAFNVELAQVRDVVSDKTIGLMRMQFWKDSMSRIFQGDPPQTPVAVELAGVCGFYKLSKRWMERIVEARALQLNRDSFLSIKEAEEYAEHSNSSLTYLLLECSGIKNVQADHAASHLGKAQGLVTLVRAVPYHAARRSVLLPMEILAKHKVSQEDVIRGKDAQPVKDVIFDIASVAHQHLEKARSLRSDLPDKCYTVFLNAAVCDHYLKALQQADFNVFDGKLQQRNHLLAYSMFFNKLRKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQA0</accession>
    <name>A0ABM0JQA0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC101860018 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101860018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099016.1">
        <property type="nucleotide sequence ID" value="XM_005098959.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099017.1">
        <property type="nucleotide sequence ID" value="XM_005098960.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860018"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF15">
        <property type="entry name" value="SLL1173 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="155"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099017.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38701" checksum="4C42E1DCE3770486" modified="2025-10-08" version="1">MRLQRLWNSYAPPLVKKNSSTVVIILCIIAVYLVWKFIWFKQDSLSYLCSSEENLKQASYYEKLGVHIIPSTPHRNRIQEKREGTSEELASASADCVPVMTPDGAHSLLTCIHDPAIDLMLSAHLKNKGAWEKENVASVYNAHQLFPNLVLVDLGCNVGAFTLPAAKHGIEVVAVDAVMPSLRLLQRSLLINDLSCPVTLIHNALYKSRKKMRVVIDPTNIGGSQVAEILDFRKDKIPPSQTVDAICLDDLVPFVRGRDVFLKLDLEGMEVQVLQCAQEFFSQVDVKVVLLEWMFYRHHEEASGILKSFLTSHGLSPTWGVNPDRVIDLDASHSWPDNVFWMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQI4</accession>
    <name>A0ABM0JQI4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LOW QUALITY PROTEIN: emopamil-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099191.1">
        <property type="nucleotide sequence ID" value="XM_005099134.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860976"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="38"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005099191.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25210" checksum="59090AC6850E4567" modified="2025-10-08" version="1">MDFAKDIMMILSLSAASVFGILGLILGYFILGSGQPKTERIVLSWMVYNALTHFLMEGSFVVLSLTETVNASSHFTSYLWKEYGKADSRWLVLDPTVVSLEILTVVVDGLLCLVVIAGIVTRGYYRHYAQLXVCVCELYGGEMXFCPEWLTGSPSLDTSNFMFLWVYLVFFNGLWVVIPLLLMYQSWLAIKAAMLHQQRTAIASAELGSGRSRDRNNGRKRKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQQ4</accession>
    <name>A0ABM0JQQ4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC101850805</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005099312.1">
        <property type="nucleotide sequence ID" value="XM_005099255.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099313.1">
        <property type="nucleotide sequence ID" value="XM_005099256.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850805"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="Carbohydrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044948376" description="Endoglucanase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="11">
        <location>
            <begin position="150"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005099312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005099313.1"/>
        </source>
    </evidence>
    <sequence length="591" mass="64804" checksum="6C5EC60348B43A2C" modified="2025-10-08" version="1">MLPSLVSVALLLPVFRAAQGAVTVQHHWAGGFQGEACIPISKDLNGWKAHLVFQEDVKSLDAFVATVTKVSNREFRLENKDYNAVEHVGDKLCFTFIGHGDGDISPAATISIEGMNSPSGSGQTGSPAHTTQSAPTPAPNTGGGTATKNYASALGKSILFYDAQRSGKLPANNPIKWRGDSGLNDCVVGGWYDAGDHVKFGLPMASSTTLLLWSLYSFKDGYVKAGQLNNMYDMIKWPLDYFLKAWDPHKKELVVQIGDGLADHHFWGRPEDMTMARPCTKVNQQKKGSDIAAETAAALALGSITFKRKGDRNYASRLLTAAESLYSFAKNNRGVFRDDAFFYSSSGDRDELCEASMWLYRATGNRQYLQDANSTWVETAWAWALGWDDKKVACQELLYEETHNADYRRDVEGYFSSWLPGGTSQIPYTPCGLAWRSLWGANRYAGNSAFLALIAAEAGIGTLRYRKWAVEQINFILGDNKHDGGCFSYQIGYGSKYPLRPHHRAASCPDRPKPCTEAQLNDPKPSPQLLVGALVGGPLQSGEYKDDRLNYTLNEVATDYNSGFQGALAGIVHLELTKNLPPTVNKCPCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRD7</accession>
    <name>A0ABM0JRD7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099755.1">
        <property type="nucleotide sequence ID" value="XM_005099698.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855951"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14345">
        <property type="entry name" value="UBA_UBXD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01773">
        <property type="entry name" value="UBX_UBXN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="557"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099755.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="68533" checksum="63EF999E030EA18D" modified="2025-10-08" version="1">MATSSGVSPELIDQFVAVTGAGRSVAVSLLEACSGNLDLAVGMHMDSGGGAGAGPSNTHTDMSGPSGAAESADDAVRAPIPQRTEVLVEEDSTKIAWRMKRPRRHAASVFDGFRDFQSEAYHEDLTRGKRPSKKRNLEDLFRPPVDITHKGTFQNARDTGSAQNKWLLVNVQNVQEFPCQVLNRDVWSSQDVRNVLKDSFVFWQVYNDSEEGKRFMQFYKLKEWPYVAIIDPFTGESQVEWHKIADGPVFCDLAKSFLSTCPVPDASQVPNAAKRQKREPSIVDATEQEQMEAAIKASLSENQTTPSSPQYVLDSDSEADVVEDSDGVETFSDTEEVIVTSTPPGPSSNGVHHPASPEPGRSASTSSSSPSKAPSISNGARLKKHPPTSSSSSSLKHLSSSSTASSSSPSSSPWVAGNNNSTVSPRSNSINSLSRLSASANNSEFRISHRDLLEAGSSSGVGTNPAAAVLASVDNVEIWAGVSQPGRDSPLEVNLENTLIDMIGGREAEVCTPDICTPEVVDSSSSNSQCSLPEADAAAGQNDVVSGEDWKDHWGDTSDPMSRLMLRFPENKREQVELPCSSSLKALVVLCTSKGFPPDKYELVTTFPRRKLSQLGSSTTLQEAGLHQQETIFVQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRZ7</accession>
    <name>A0ABM0JRZ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dentin sialophosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100178.1">
        <property type="nucleotide sequence ID" value="XM_005100121.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855263"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100178.1"/>
        </source>
    </evidence>
    <sequence length="837" mass="87425" checksum="EC09642AEDA14327" modified="2025-10-08" version="1">MGGWVRVLTSETGADTVPEGLEEYLVAGDNSSDAASLLSFTVLKQWDMGDLVPKPSQAGTSTSHDYEDPADILGPTDTQDTSDSNRTTPSVDTTDVTSDVSQPTLGETSACGQEGVGVMVASSSLPERTNSCGSRSPKISEAFAAPNKKDSGFYSVKGANSDSDSGCENSSRDAGDMDSGYATLDSLRFRQGQHGRSSSTSHGRGDPAVSETGLPSESASCGVNNSKHSSNNNSNNKSNSNSSDSLKDSRSVLCDSSLGSCVSGATSESNSPDTSPVHAACSNTSASSSAPSSSSLPHPPPTCVQNSSDKHLTSNPPAQSQSSSSSANVTDQKNPTGSDLDEGHYDRLTSTDEAPEVTDLVSPTYVKGQPACQTPLSPSNDRTVVSPSDNEYSVVLKRSSRSKSKSPETFPALPTPPPDQTSDSTTDSRNPGSDVTDSRPHESSGESSSDKEKKNTPAGEDSDDLTKFGEDLFESLLQNTCQESDADSVELDFTPRPPSMSLQPPSDINDAQHDRVFDGNSSVDSERLSSPHSLSPTSISGKLEQDASALPSSGNSSNPDLSEEGSQPLLSSSLSSSSATDDRGGAREQMSSEPPTGEDGSEDDCPPPLPTSPIPDLGPSSPSSSFTPPVDSESCPRNEGKCDPSEPSIVKDTTTASTASTSAQNSSGAEPSSSVAETKGENLDSLDGSSHVPKIAANENACNGSAVSPNSTADDVFFKNEYPLGPSSDAVLALASNPDATEGELTAAINALKEKLTQIKRRRMAVHEKRQKVSSDEERLACEKEFAALDRAVEGTDLDIRHLQNYLDVIQGQTLEAMKAASSKKKPGSRKKKNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS06</accession>
    <name>A0ABM0JS06_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100194.1">
        <property type="nucleotide sequence ID" value="XM_005100137.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859177"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005100194.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14547" checksum="360D53C28A0A34BB" modified="2025-10-08" version="1">MAKVKAKDLRGKTKEDLLKQLDELKNELQTLRVAKVTGGAAAKLAKIYTVRKSVARVLTVINQKQKENLRRFYRQRSHKPKDLRLKKTRAIRRALTPYERSIKSKKEMRKNRLYPQRKYAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS19</accession>
    <name>A0ABM0JS19_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein Mo25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100218.1">
        <property type="nucleotide sequence ID" value="XM_005100161.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845700"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100218.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39753" checksum="DA8BE494F6F60A91" modified="2025-10-08" version="1">MPFFGNRNKSPQELVRSLKENLLLLPNLKEKEYKKVNEDVSKTLQTIKTLLYGTVDQEPATEQVAMLSTEMYQNGTLLVLVQNLARIDFEGRKDVVAIFNNLLRRQIGTRTPTEEYVCQNPKVLIELVKGYENQEIALNCGMMLRECCRFESLAKILLNAPEFYKFFEYVEVSTFDIASDAFSTFKELLTRHKMLCAEFLDQNYDEVFTHYQLLLNSENYVTRRQALKLLGELLLDRHNFSTMNQYISNPDNLKLMMNMLREKSRNIQFEAFHVFKIFVANPNKPRPILDILLRNKDRLVDFLTRFHTERSEDEQFNDEKSYLIKQIKELRLPAEADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUT8</accession>
    <name>A0ABM0JUT8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101849623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102026.2">
        <property type="nucleotide sequence ID" value="XM_005101969.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849623"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005102026.2"/>
        </source>
    </evidence>
    <sequence length="646" mass="72648" checksum="D0FCFB319173CB48" modified="2025-10-08" version="1">MAAKEERASWGRHIEFIITCIGFAVGLGNIWRFPHLAYKNGGGAFLLPYVISLVFMGIPLFCLEILFGQFASLGPITIWEINLLFKGLGYTMVCLAAIISIYYNVVVATAIFYLFASMQSSLPWASCGNEWNTCSCRTSDMNRTLSDPLIWYDSRGLNCTDADPDKTKSASEEYYYNYVLEATDGIFDVGKLKWDLTLCNLLAWIIICVALIKSVQSMGKAVYFFALFPYVLMTVLLVRGATLEGAWRGIEFYLKPDVDKLLDSKVWKQAASQIFFSLSCCTGSLTAMSSYNKFNNNVLRDSLIIPIINCLTSLYAGFAIFSVLGFMAETAGTPVANVTTDGPGLVFVVYPEGLSNMPVPQLWSILFFFMMICLGFGTQFPSVETVLTALQDEFPALRGKRRSIVFRVTTCLIGFLLGLPLTTQGGSYLLDLCDIFVGFPLLLVGFFEVIAIVWVYGFHNFAEDVLLMVGDWYPTRVLFYAYYSWNWLVVTPVLIMAIVIFDCVTYEPIIDESYPEWAEVLGWLIVGFIMLWLPVWYIARYCYEMYTAPATESAWEVFVRMNRPTIKWGPHLPENRTLPRYLRLLEAENTVKLPYYEKGGAMKAEEGGGSTEKGQGSYPPVYNDAVKTGHINPEFEPDSAVENTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW71</accession>
    <name>A0ABM0JW71_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase RBBP6 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101860586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005102950.1">
        <property type="nucleotide sequence ID" value="XM_005102893.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860586"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="670"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1154"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1528"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1612"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1709"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1742"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="671"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
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            <begin position="732"/>
            <end position="743"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <begin position="744"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="762"/>
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            <begin position="807"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="827"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <begin position="858"/>
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        </location>
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        <location>
            <begin position="894"/>
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        </location>
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        <location>
            <begin position="916"/>
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            <begin position="969"/>
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            <begin position="1014"/>
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            <begin position="1043"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="7">
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            <begin position="1058"/>
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    </feature>
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    </feature>
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            <begin position="1940"/>
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        </location>
    </feature>
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            <begin position="1967"/>
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    </feature>
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            <begin position="2011"/>
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        <location>
            <begin position="2032"/>
            <end position="2061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005102950.1"/>
        </source>
    </evidence>
    <sequence length="2068" mass="231339" checksum="8AF0E57E06B3A892" modified="2025-10-08" version="1">MSCIHYKFKSSLDYNSVTFDGLHLSLTDLKKAISLQKRLKPGEFDLEIVNAQTGVVYERSDELIAKNTSVTVSRVPVTKSTASSTQKSWEAFKQKCAKVKEKERQMTLEKLKQTPDLAGAPASEIDKIKAVIDQSTKGFEPSNFMGKHPSGVPAEHYVCKRCGQKGHYITNCPNSNPEERIMEPRYKRTTGIPATMLTIVDDPMHPGALLTSGGQFAVPTVDVEAYRDSKKERPPFLPPDTAKESEVRKIPRELLCNICDDLCVDAAIAPCCGTSFCDQCLREELLESEVHQCPACKETNVSPDRIVANKSMRLAVTNFLNDTGYTKLSKLLLSAQVKRRRSNSAGGDSSSPVSSVPKSSALEISAPANKLSLSSGAAAPNKSEEVSSAPSGSPPSTLSDLPSRAYGQDYQSRPGRHSSEQQNRYRQGQRCPPHHKPWRSHNEPFRKDFSSYSNTSSNLKTLADSNLSDNPLQRPAGASTYDRPQGRSQDRGHLHGSASSHAEPERLSSAEEQRQSRKTPPMADARPLIPQSLASGRPNPWLSGSRPGVDNTSSVPVATSLSSGSLHGQVAGQYMGLPTHPLPILTVPPPGLPPPFTALPGFPRGFPNPLFGPPGLPAPGVPPTVQPQGPGQKAPLSEAEFYEAQQIIKEASRSPKKPVDIFDSFADLTSRRSRSTERHRSRTRSRSGSWHRRPSRTPSRSPAKRRSRSFSPSKGSPHSRSRQRSSQRSRSRSYGPPRTSSQRSRTRSPRRFSKSRSRSHSGPRQSRPLSRTRSPLPPLRRSKSPLSPLRRSSKSPLRRSSLSSMRRSSKSPLRRSSKSPIRTSKSPFRRSSKSPLRRMSKSPLRRSSKSPLRSSKSPLRRSSKSPLRRATKSPLRRSSKSPLGLRRSSKSPLRRSSLSPVRRSSRSSLLRSSKSPLRRSSKSPLPRRSRTRSKSFARYSRSRSKSWSKAKRPRSRSYSRQRSPRRSPLRSPGRRNSFSPRRRSKSFSPRPKSPYRSRSRSPRDKKWSPRPRSRSPFPSRRSLSPLKSPSRRSPSPYKKRPLSPLPPRRQSPPPFQRGRGGGFRGRGRGGFRGSFDRPNQDRFRGPASPPRGTPAQPPAHPQSSGAGPVPNLPPVPYFPGMGIPPPEEYFKYNPAGYQEFVRNLYSQFGPQAQAWAQSQGGAGTGGIMPPAIGDNMFPHQPPSVHPVPSASEQQRPPWDTTVPMSPSQRPRSFTPPGAYPQRDRRQDNYGPSDHRNENYPPRDRRDGNYPRERREDNYAPRDRRENNYVQRDRREDNYPPKDRRDDNLNKDKTDRERPWERDQRERPLDRDRDRRGEREREDRYRRDPTRDRPESNREKGRDGNRNKESERSKGRDAPRDKDSQKDKERDTGRTKDRGVNDRKKSPPKKSKEEDKDRLKGKDKKRTERKKEDKENKKTKKRSETEMDKGEKDKSSKKDSILSKTSPISDKEFDSPAVSEKVEQTTARAGSVPSKTGDVSKKEVTDGSSTVKLDSTAADARAQNVTGDSVAKGKKAITVKKADGNVVKKSKVKAAATDDGTTAGKKGKKTKKKKLTFGSSEVDAKQGLKKKKLKRLVDYKSENCTSEDGEDKLLRGSPAKKLKASADTGIVAEVKTEVEKPTAGDGGSGDQSLSTTTVPEVSSGVKNEASAGGQVGPSVSLAPPAPVPEKEMVTDATVDSTVKDVKEELVPELPELSKWEREDFDLLDTIEQHHSKDKTGPPSKMMLPRSVVDKAEKFLTQKPMKNAVVTAGHVSTSSKSPSLSPSRKASEGRSKSPVTKAHRRVFMEGKKESRDKKTLDLQITVKADKVNADADKSKGEPERHKRDSSDRKQTSSSRTEDSRHNRYHQNEYEEDQRSVVRSRSFERELHVGSKSNKNKEKEKRAGKQDRTRGSASEKSGKYESRKDSSKDRHRDRSPEPRERRQNKESQLDSTTDSNVKSSKDLRHKIEEKTKAKSAVDHRKLSVMDESEFVPDYEDLAPESGSDNEPDDGTSQNSGASSPDRKKRKKSEEEEEGDEKEDSSEKGDDEGGKAKKARKKHKHKEKSKEKKKHKKKKHKHKKSKDREAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW72</accession>
    <name>A0ABM0JW72_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inactive serine/threonine-protein kinase PLK5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102951.1">
        <property type="nucleotide sequence ID" value="XM_005102894.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861138"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005102951.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30077" checksum="28A7CA94D72000DD" modified="2025-10-08" version="1">MSSVEQIRVIQLHKEEDVFHYNRIHYSSVLHQGQRSKILLARSNIIPDKKFAIKQMPLLSDEDRDRFTRELCLMKLAVDIRGVVTLLSYPVICGPTGYILMLSQRGKLTYYRWMKVFVRTAVSLRSLHKKKIYHQDLRPQNILLTDSHVAFISDFGAASLLPEGCDQVDTWTAGFRGPEADQEGGPFCPFQLDTYSLAVSMWQVLSSLCPVKNKPLDHLDNIPPQYAALLRNLLVPEPDRRWTLDKFLTEALELHPDLSCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXA0</accession>
    <name>A0ABM0JXA0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101861059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005103715.2">
        <property type="nucleotide sequence ID" value="XM_005103658.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861059"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF334">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005103715.2"/>
        </source>
    </evidence>
    <sequence length="352" mass="40100" checksum="0DFCDA5151176BC3" modified="2025-10-08" version="1">MRNSILIRLFTVLSVFAVVMTSLHLMLQMIETGLFSRVDVTKNLLRYKYLMENETFAAAYYGSLDQSKLRRQSGHSSFPRMPPPLPLLRNLSSKVEAFLEEPVINPHPYGYLHNPEMMCGEKHVDILFVIPSAPENVWKRRKVRKSGLGLYSRLKSFKSVSVVFFLGLPDAHKKQANLTQTIVCAEAEKYGDIVQENFTDVYRNIRLKAVSMLRWAATYCSNASYVIRMDDDVAITVNVILSSIKIVGSRYDNFVLGDVKKDWGPSRYAKNKYYVTKAEFANDTYPPFALGGLLGYPLKTVRLLFEASLRVKPLWLDDVYITGLCAPEIDAVLVSDMGFRFRHLKEDVNGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYK8</accession>
    <name>A0ABM0JYK8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phospholipase A-2-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101863529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PLAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104581.1">
        <property type="nucleotide sequence ID" value="XM_005104524.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863529"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="362"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="512"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005104581.1"/>
        </source>
    </evidence>
    <sequence length="766" mass="82611" checksum="BE7C7F1F8998417E" modified="2025-10-08" version="1">MATPYKLRCNLTGHEKDVRALVSSLFPEHGLISGSRDNTSCIWAENEGSNSFVKELTMRGHSNFVSSLCVMPPDDSYPQGLIITGSNDKTILAYSPGVPEPVFKLTGHTGNVCALASGKFGFLLSGSWDMTARVWLNQKCVMVLEGHQMAVWAVGIISGQGVMLTGSADKSIKAWKAGKCIQTYKGHEDCVRGLGVVSEAEFLSCSNDATIRRWAVTSGDCLAVYYGHTNYVYSLSILPNGQDFVTGAEDRTLRVWKDGKLSQTIYHPSESVWAVCALPNGDIASGASDGIIRVFTQDPKKYASDEVIAAHEASLASAPVASQPLGDIKVEDLPGPESLDQPGKKDGQTTMINTGGTVDVYQWDASQTKWVKIGNVVGSSGSTQSTSGKTLYEGKEYDYVFSVDIKEGAPPLKLPYNIAEDPWMAAQKFLHKHELSQLFLDQVANFILENTKGVTLGTGSASGYSDPFTGGDRYVPGRDDMDTSGATPAGSDPFTGGGRYVPGEESTGSGNTHFPIKTCLFFDTASPIEQILGKLKEFNKSVDDNLHVPEESLDELGSLLTGHPRGDSIKTLDQLITWPHEVVFPALDILRMAIKEHEVCRLFCSRPSVIDLMCQHASQGNNNACRMLSLRTLTNLFRHPEGTELNISRIDSVLQVAINGRDMTTKKGQIAVATLILNFCVKLAASDDLENKSKCLQAAGEVLGSNFDPEAVYRLLVGVGTLVGQDDGCKALAQSIDLPELIAKLNTSESGKLTECSKLVSSSFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ37</accession>
    <name>A0ABM0JZ37_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862746</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104926.2">
        <property type="nucleotide sequence ID" value="XM_005104869.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862746"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104926.2"/>
        </source>
    </evidence>
    <sequence length="245" mass="28224" checksum="BC6E346877B80D62" modified="2025-10-08" version="1">MSLDYRKKTYRPSRPNTRNITSYGSMSKWISRQHENPAPRPEVARHLMERANPSPQFTKKRPIIKPSPTGMPSMYDTYMNKSSAVLDETLPVHLRYSNHCGYDDFHKAFRAVQDKHPELSYPHFGPPSPVNGWHSQRKLRHGRQGGSWRHVREVLQAGGNRIVFVDGQVSSDDLMKLDSIPGGHLILPEVDRGTPSPRLVQQMNRLYDNSVAISTDRRVQQVPLAKYSMLESQRALEKDNWNIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0M0</accession>
    <name>A0ABM0K0M0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860995 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105951.1">
        <property type="nucleotide sequence ID" value="XM_005105894.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860995"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046174951" evidence="1">
        <location>
            <begin position="17"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="286"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105951.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="45440" checksum="017175C5CA997A80" modified="2025-10-08" version="1">MRLVLLLLSFALSSRAELEMKVTPKVIEPDFTTSFTLNCALLENEDAKVVSLSIVRRTNALGNLQTGASERIATLISLTPTTPTLYPGFELLTTIGQITSFETELGSYLKLVWPSPSIDELGLYTCEAVVIGANGQLATLVAQARVTTADPVTDRLLVSLDKLEKSMLDINSTVVELQGRVDNITAEQQLLKEEAAAATTVPSFFEEGTTLDLTTEDPTLSTLNPRDEYLFRLASVVESLGSKMDAFNASIGTLEQKLTKLETEPEIQNATVAEDGPDHIINFFFLGNSTYFLITRENRPYSTYYAQATCEKENLALVEIQNQDELNGIEENIAPLVKDNGLVLVSGRRSAGRTDWFWQGTGDEVTFFNWATTEPAEENGARCLALTKTPSLKMTAVNCGTSVPNTYFLCEDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K160</accession>
    <name>A0ABM0K160_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106336.1">
        <property type="nucleotide sequence ID" value="XM_005106279.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852262"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="4">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005106336.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45392" checksum="442B998F9AE7AB1A" modified="2025-10-08" version="1">MKKLVKMKLRCEVQVSDHQLCIKKPGKAAFAQVSVGRKPGHKDGPIYVMICTAQNRNGTKYVIWKNLKQIFGKFVKDGKATVRFMNPPHDLAFSKANADLLDTFLKVVKLVAQGKGLPDESLSSLAPASLKQVERPVTSLSVMSPSEYPMSFPKSLTKLMICNCRLRRVSPHVLSLNLLTTLDLSFNSLSSLPEQMSQLKSLTSLSLAHNEFVTFPIVLCKTDVRRTLLVLDMKHNEMHSVPSCIKECEKLQSLVLSSNKLHSLPQCLGHMKSLTSVSASDNKLQYLPGSMLRKTWELADFSNNPFNLSIDNSTQAASFAVPSLAEWSARSVVNHEVQFTKEDLDLHSIQYVQGAHFCVCGSACFETSVRATKKRPLWATSAYQGDVPLQMHFCSLRCLKLFNSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K217</accession>
    <name>A0ABM0K217_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein shisa-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106908.2">
        <property type="nucleotide sequence ID" value="XM_005106851.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862062"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046023769" evidence="3">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005106908.2"/>
        </source>
    </evidence>
    <sequence length="178" mass="19187" checksum="904982BDFEB660C9" modified="2025-10-08" version="1">MAGSFLLLVLLCVFYFLTGCEAEYCGNYDSLKYCTYGCCNEYFHDCCDPPVGMIIGIIGAVGFCIFVIALIVCLCRRRRLQGQVIYGQQPGAAVVVAQSNNTTMNTTGMQPGVAYPQYPAAYPGYPQYPAQPAACPYPAHQPQPAFAQGPPAYQDVPGQNAAPQYAQGKENHGYDGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3H3</accession>
    <name>A0ABM0K3H3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier organic anion transporter family member 4A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101855445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107893.2">
        <property type="nucleotide sequence ID" value="XM_005107836.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855445"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF100">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="84"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005107893.2"/>
        </source>
    </evidence>
    <sequence length="221" mass="24115" checksum="3513937DB840605C" modified="2025-10-08" version="1">MIIIDIIIVSIPFTGIGFFRTVYAANEYNVPMAEAAMLSGYVQAVGNIAGTLLSAWISTRVRTKAGYIWIIFATYAVVTCVVPAYLYLDCPNYPVYGHEGELGLPANMTDMCGCETEKQLLSCGSDGLHYYSPCHAGCTSLDGKTFMECTGLATGNGTVTPGLCDTTCHDNFVIYTVLNGVQGLVFTMAMVPRRLLLFRVVSAQDRGFAGSMLFFFFDFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3S4</accession>
    <name>A0ABM0K3S4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EF-hand domain-containing protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101861235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108081.1">
        <property type="nucleotide sequence ID" value="XM_005108024.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861235"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="9">
        <location>
            <begin position="88"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="9">
        <location>
            <begin position="236"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="9">
        <location>
            <begin position="413"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108081.1"/>
        </source>
    </evidence>
    <sequence length="646" mass="74728" checksum="A5E9B73B46EA06BC" modified="2025-10-08" version="1">MEGLPFLPGNTFVDPTKSKFHISQSLGYKNGYALPKRPERGVGGTQLFHNQLSESELDELANFSPTLTYGQAKQAPPAAFIPAHVAWDKKVLKFSGYYKQTVHESPEEYYRVRPVEIFYYLEDDSISVIEPHVENSGMPQGKLIKRQRLPKNDQGDSWHWKDINLGMNITFYGKNFHITNCDKFTSDFLESEGIIVNEPQQIPLDPYITKRAEAAALRTYDTPSSFDKLKQFKELDRKVLRFFCVWDDRDQMFGEMRPFVLHYYLVDDTLEVREVHTPNDGRDPFPVLIGRHKVPKNRFDLPSSFPSVVMEISDQEIKQYFTPKDFEIGKTLSIYGRRFLIYDCDNFTKGFYYNHFGTTNFAPVEVKGMAKELPKMEIAEYNNFGSIEDSLQSCNSLIPQPPKKDFIKMLENDHRELRFEAIMSPGCKDTMRPEDKGRRFIITYRLADDMLTIYEPPVRNSGIIGGKFLERTRVAKPGSSLEKPLYYGPQDFYIGAVIEIFKHRFVITNADAFVLKYMEEHRGQFPEQTVSSVREKVGEYAGPQETMKGGPMKVQRQPGDLELMVRQVRAQLKKIAITDKARVDEMFLRYNNDRTGYIDINNLRDLCKRLQLPIDDDVLCAVICQITSDPEGRVNLEDFRQFIEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K410</accession>
    <name>A0ABM0K410_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bystin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108239.1">
        <property type="nucleotide sequence ID" value="XM_005108182.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857980"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108239.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="49480" checksum="945F6A71EFD009FB" modified="2025-10-08" version="1">MGKVKKQRKRLHEQIAQEQEAQPSRRTGKERNRAEDDAFVDEKLSKKILAQARKQEEDLDVSNSEDAWPSLSKKKDSGKKAVRLGGASAAAESDSEDEDVTKHLFENFSSLEKTVTEINEEDEEDLRRFMNPNPKERRTLADIICEKLAEKKTAMTEMMSEAPIIDEELDDNVRQHFIQIGDVLSHYRSGKLPKGFKVIPSFPHWQQLVELTRPENWTAASVYAATRIFVSNLPKYHFKEFCNLILLPRIRDDIAEYKRLNFHLFQALHKAIYKPGDFYEGIVLPLCESGDCTLREALIVAGVVSQTSIPVGYSAAALILISKMEYNGANSIFMKTILNKKYSLPLSAIDAVVEHFMGFREVEDQMPVLWHQCLLTLVQRYKQDLTKEHKLGILRLIAFHDHHEISPEIQREITSSKRNRGDPEPEDEDMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4V4</accession>
    <name>A0ABM0K4V4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Uncharacterized protein LOC101847221</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC101847221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108794.1">
        <property type="nucleotide sequence ID" value="XM_005108737.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943733.1">
        <property type="nucleotide sequence ID" value="XM_013088279.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847221"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="64"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="313"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005108794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012943733.1"/>
        </source>
    </evidence>
    <sequence length="682" mass="76260" checksum="60186435E05B2360" modified="2025-10-08" version="1">MILKGMPFDTVSYDFVNSGDNSSSGRSEPVWNVTVLTQLNDDIFRRLIPAIVVLVAMMVLGVAGNVVIVYIFIRKMRKSSQNLLLLSLGVFDLVSSCVGVPSEIYDMRNYYFYQSSQACKAMRFLTTLPLLASILVLLVIAVDRYRKICKPLHHQIHLAHARIAIFIVIVVALIFSVPALFLYGHRTFPTPTAGVMGHDCSVDDAYRNSVLPIVYEGVFAAAFVLCTLVLVSLYLRIWMETRRHRKYMKTHASMGRIKLDEFIGSSVCLESSTDPTPEVHTLTSQASLSSKSPASSLRSLKKRWRSGRYNAKLRHTQVDQRVEPETTEPLPVKNVALENGGHGDGRNDPLVDTGTHEPVSDVVNTNSSPFMNRRQSAVTFELSPYPTESLDSTTEDFDSQNEIREFQTVDLDSQADNFDSSGENLDSSVKILNSKSGDLDCSKEILDSRSNNFDSSGENVESSAENFDSKTENLDAKADHQDSQIDIVNFPSDDSKSKEALPSTDEETELSSKKENLNGITSTANLENTTTPARESQESPEKDSAAIQNQRIQLRKPEVLRKPGRLLKTKSSQSLYYAARVKKALRATRMTVIACVITIGFILSYLPHLILIILRSVIVDFEHNFNDASLVLYNIFLRSYFVNTVLNIFVYGSMNLEFRSALVCVWKKIKSPFVRDSSQSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5B7</accession>
    <name>A0ABM0K5B7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101863617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109109.1">
        <property type="nucleotide sequence ID" value="XM_005109052.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863617"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="6">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005109109.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15883" checksum="6313182B15DE7469" modified="2025-10-08" version="1">MPYQRFVEVGRVAFVAHGDDKGKLVVIVDVIDQSRALVDGPCSGVNRKDMNFKALHLTPFTIKIGPSARSGPVRKAWEKADVTKKWSESTWAKKLASRERRSQLSDFERFKLMKAKQARNRIINVEFGKLRNAARKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6F2</accession>
    <name>A0ABM0K6F2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple epidermal growth factor-like domains protein 6 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109839.1">
        <property type="nucleotide sequence ID" value="XM_005109782.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852437"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045198440" evidence="4">
        <location>
            <begin position="30"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005109839.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="60857" checksum="501E4FA62302165C" modified="2025-10-08" version="1">MPRFRTPYPSQRVLYISLLSIVFTTQCSCQIICEESNNRTIVEKYMFRSFVKGSYSICESSCRKYDGWLAAMNTRQEFAVMKLISNSLDPLDTLVFLNAQANTEYNLHRYVNGTRVDNMEFPTPWCSLTVTLKMNSKCITYSTPSAADKNCLLMFPCDSGDPLYGFCETYLNITGEYKDCEDTLCICPGGKLSCSCPKDCLKLYATGHCDYSPCRYDRYGPSCEYQCRCKDKEPCDLVTGNCPNGCQENWRGAACNETACPVNRFGPFCKQFCFCKYGDQCNVTTGDCYYGCEDQMYGRTCETSDCWPGMYGPKCRKPCSLLCGGGVPCSRTDGRCMSEECPVPFRVLPFCNQTVCPDGKWGSNCDKQCECEPPIDTCDVKTGLCFPHRSVPKELLTNSSCPEGLWGNYCHMTCMDKACQSCLKTNGGYCEKCRDGYNLTATKDCEKDSFVLMILVVFLCVLLLILVALLLLLLKRSTKKKEDKTELVEEEQDVKEEEEEEENATPSVEGEAEGKERGSEGQVDGEEGEHHDEADDEEHPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6P8</accession>
    <name>A0ABM0K6P8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of G-protein signaling 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110017.3">
        <property type="nucleotide sequence ID" value="XM_005109960.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855148"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042651">
        <property type="entry name" value="Rgs22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46583">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46583:SF1">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="136"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="320"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="489"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110017.3"/>
        </source>
    </evidence>
    <sequence length="879" mass="100266" checksum="D7F9BCD781DC3827" modified="2025-10-08" version="1">MAARPSSASVTGKPPKKPCPCRPLTAVLGEGAAERQAPSKPLTPVKKPKDLLSPMLRIVDSKSGRRRVTSAPVVRSMDQPEARTTFYRQDSQDSSKSCDRKSSVAGVPGDAVGPETMEFAEIRDCDFLGSERMEFLLQALHHEPSSGKTFRKYIEKSERPDWVNCLDFWEQVQEYRKLFYMDKLDLFLIAKMAKSIFAKCIVEGSAQNIGVSESVELQVMERLSPPYEDLFDEAEEHALKVLFEAFQLYLSQDVKTYCKVERADVTRRLETKNTYILNLQKQGIIKERPLTPEDPMAGYVEPVYDESLADRIPAQFRDWTLDKLLHNRLELESFRQYLVDNYAEMDLKCWMDMEAWRRTPPEDDRKRDQRARDIKKNYLNKKYFFGPSSPAGKEGQNKVMEVGGGWGKFLEDKPAGDSILEAQKYVRERLEKKHLPLFLLSSEFQSRQSPALSMADSAEDVMVQKKRRSQAVLKLLESKWVSSTKEIFLFQHALQNPITCRLFCKFLALRGDNLENDVLFWLEVQNYKKMNHNHTDDANLVQKINAIVHCFIDSTIPPSLQIDIPQEMADRILDHKHEKGPYLFREAQLATFRILLTHWQPFCEFRNNMNTDERALTTLERHRVIARQKEAAHREELEKQREREEADTLLPRAGKKVSVGVAFKERMLRLELGLGEQDQLPEDLFEEEDKGDKISFSYSDYLSELREQVTVEPGLLESSSFYNLMLTSYDDNASQTVRSNVVDKSVDTAGSHKELEGPEGKADHTEHLDQSLGRKAGAGGEEEALKSRRSSTQTDRRRTSVTSEVPKRGAEQRPEVSENLKKKKKKAPPPSVPPPSAPPPASNEGKPPAGSSARPVSGKENSRAQSRHIPPLVKTEFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K704</accession>
    <name>A0ABM0K704_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101863547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110223.1">
        <property type="nucleotide sequence ID" value="XM_005110166.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863547"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049352">
        <property type="entry name" value="Rost"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21534">
        <property type="entry name" value="Rost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110223.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35926" checksum="27C7A274EB724C28" modified="2025-10-08" version="1">MAASILREEFRLKHFRLNHHNDRAFYCGQWKLPHIVFVLARVLLAGYSVYAMIHLVVNHYENGNKGALMRFFTVWSYILLMIHLVYAALLSIVFFRPGRQGIQGDDSEKQAGVPMTNRNAISTISNGGKDGHTAENGHNGGVVIGDGSKKKSPTPGEHEIVFGNDTSLSTAWYFKLSWVLSNFITCAAPVVTIIFFVAIYPKQNKNESSVGLQDLNVHALNFVFVVVDHLISARPVRLLHAYLPIIYGLVYIIFSVIYWSTDHKNHVVYEILDWNKPGIAFAVTVGLAVVAIPLLQFAFFGLYRLKLYICKKVHGYDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K707</accession>
    <name>A0ABM0K707_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Direct IAP-binding protein with low pI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101845360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Smac/DIABLO protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110230.1">
        <property type="nucleotide sequence ID" value="XM_005110173.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845360"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009062">
        <property type="entry name" value="Smac/DIABLO-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015142">
        <property type="entry name" value="Smac_DIABLO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32247">
        <property type="entry name" value="DIABLO HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32247:SF3">
        <property type="entry name" value="DIABLO IAP-BINDING MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09057">
        <property type="entry name" value="Smac_DIABLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46984">
        <property type="entry name" value="Smac/diablo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005110230.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28920" checksum="5CBEFC4D82F48C27" modified="2025-10-08" version="1">MFRKLSRLACELPRVRMKFFQLKRSLSPLKRTLVTSAVLCATPVVLETFEPNDPRLKTPECLKNAAGMAVDSSSAVLSQTVYAIFRIEEEYKDLMDLMVKLIEYQLQVVGHKAEEERMADIILETRLEIDKVKRRKQDLELLFASAEKLADATAEVAFATGMEFASTSMGERLYNTQREVKRVQEKTEELEQRLQQVQLKVIEVMGQLEEKEKKKQKQSLSEGGEVLGDAGSDAGVEEGEEEREDEDGLLEEGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8U5</accession>
    <name>A0ABM0K8U5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable splicing factor, arginine/serine-rich 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111577.1">
        <property type="nucleotide sequence ID" value="XM_005111520.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854912"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111577.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="36550" checksum="833AE8B7AE5B31E4" modified="2025-10-08" version="1">MSRRRDSGDLGRYGYGGYRVYVGDIGQRIGRTDLEKEFGQYGPVTDVWMGRRRDPDMANFAFVVFRYPEDAEEAVRDRNGRKVCGRQVRVEHAKPIGGGRQGGGGGGGGGGGGGGGGRGGGFGGRGFYGGGGAGGGGGGGRGDYNDGWYGPPRDMPPRGRSRSRSRERYRRSPSPRNYPNNGGRWQQQSPPMERRRNDSYNEPPPPKMAQHSPPESPEPPRRHKKKSSKRQVSVSPSPPPKRKSNKQPGSSEDSASSSSESRSPTPPPKKKKKKRKKQRTHSSSASPPPDPGYGGGRESRVPPPPSSSGGRSGGSGKKGKNSSSKGKQKYEESDGYSSSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9H1</accession>
    <name>A0ABM0K9H1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centriolar satellite-associated tubulin polyglutamylase complex regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101857992</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CSTPP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112084.3">
        <property type="nucleotide sequence ID" value="XM_005112027.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857992"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22959">
        <property type="entry name" value="DD_C11orf49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038968">
        <property type="entry name" value="CSTPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34252:SF1">
        <property type="entry name" value="CENTRIOLAR SATELLITE-ASSOCIATED TUBULIN POLYGLUTAMYLASE COMPLEX REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34252">
        <property type="entry name" value="UPF0705 PROTEIN C11ORF49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005112084.3"/>
        </source>
    </evidence>
    <sequence length="287" mass="32853" checksum="F072FAD61F7D28F3" modified="2025-10-08" version="1">MSILSDDNFSMSADKYLAKHNILAYLEDSITQLLEHREENPKVVPAKFLCEYFCSLRDGNHTMFREFSFIRSTPHNRASFVVLFWKCFRQIGKKGDLLSIQEYHSLLGLLCPDFPFQLVQKTARIVLIDDALDCLISFPDFIYAFQVQFFYEEFLEKSVEIYRGLLQTMQSPRDPVIVPTSGERDAKVHQSPHIAADGVDAMQFFRSIYPLLDRVDYSTPPLSSLKEILFNLPRISFYEFLMSIAKSDSINAHIGRLPSKADLLEGADAELSSKPGKTPRTSKSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9H8</accession>
    <name>A0ABM0K9H8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Craniofacial development protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101863398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112107.1">
        <property type="nucleotide sequence ID" value="XM_005112050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863398"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005112107.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25050" checksum="50E83EC130B4A18B" modified="2025-10-08" version="1">MGLKPRQGTLSSETMTALHHTLAAFLQLCQYLLEKKNFHYVLLGKFQTDNLEFRFSQYRQMSGSNYLVFRRFSSGLATQTGKKAYVTETATKRNHISVCDGPSESLVTRMNAGNESRQEAVCRKMEDLNTAKTKVIIGQWNVRTMYEAGKLAQVTAEMRRYGLHVLGISESQWTGSGRLRTATGETLIYSGREDNRHREGGAVILIRDLRNASWSGNRSTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9P5</accession>
    <name>A0ABM0K9P5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transforming growth factor-beta-induced protein ig-h3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112281.1">
        <property type="nucleotide sequence ID" value="XM_005112224.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863400"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045585852" evidence="1">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112281.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14136" checksum="9A92D48CE98D301D" modified="2025-10-08" version="1">MLRLLLLAVALTSATGQLDSRTIMQYLQDENMNTLTAYLTATGLDKLLADPGSTAVTLFAPTDQAWNKLPSNIVFSLSTNTTLLKKVLMDHVVNQVVLSQYVRDQDAKTNLNGGAMVFRVYPNGVRYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9V5</accession>
    <name>A0ABM0K9V5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cyclin-dependent kinase 20</fullName>
            <ecNumber evidence="5">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cell cycle-related kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cell division protein kinase 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC101850770</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005112397.1">
        <property type="nucleotide sequence ID" value="XM_005112340.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850770"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07832">
        <property type="entry name" value="STKc_CCRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048002">
        <property type="entry name" value="CDK20-like_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF171">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 23 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 23 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="4"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_005112397.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39384" checksum="AB6CF2B0159EDF34" modified="2025-10-08" version="1">MEQYNILGRIGEGAHGIVLKAKHIESGEIVALKKVPLRNAEEGIPNTALREIKALQEIEDNPYVVRLREVFPHGAVIVFVFEFMLSDLSEVIRKVEKPLTEAQVKSYMLMLLKGIAFCHENNIMHRDLKPANLLISSTGHLKIADFGLARVFQNKGDRQYSHQVATRWYRAPELLYGARKYDEGVDLWAVGCIFGELLNNSPIFPGETDIEQLCLVVKVLGTPSEKTWPGMSKLDLPDYHKISFPDNPPIPLEKIVPDASEEALDLLKQFLVYPSKQRISAKQALLHQYFFTEPLPAHHSELPIPQRTSRRSGLQLKHQAHEYNADLPIEDSLINPDRLAPHVIRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAC1</accession>
    <name>A0ABM0KAC1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translocon-associated protein subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Signal sequence receptor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-gamma family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112740.1">
        <property type="nucleotide sequence ID" value="XM_005112683.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857084"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009779">
        <property type="entry name" value="SSR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399:SF2">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN TRAP , GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07074">
        <property type="entry name" value="TRAP-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005112740.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21007" checksum="6EE32A14FD996AC4" modified="2025-10-08" version="1">MAGGKQNKLSREEELLLQDFSRNVSTKSSALFYGNALIVSAIPMWLFWRIHQMDLYQSAIIFIIGTIVSTYFVAMAYRNVKFILKHKIALKREDAVAKEMMKKLADDKRMTKKEKDERVLWKKNEVADYEATTFSIFYNNSLYLVLLIVASFYILKNFNPVLNYGCSVASAAGLLALFSTSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAT4</accession>
    <name>A0ABM0KAT4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized oxidoreductase TM_0325</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101853220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113091.2">
        <property type="nucleotide sequence ID" value="XM_005113034.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853220"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005113091.2"/>
        </source>
    </evidence>
    <sequence length="273" mass="29165" checksum="47F1405475C714E4" modified="2025-10-08" version="1">MSSLSLKGRVAIITGSSSGLGQATAVLFAQRGCAVVVTGTNEKRLQETLEKCQKAGLKRDQILTVAGDITIHKTREEIVTRTFETFQRIDILVNNAGALYTGFIKDLEEKDIDTTFNLNFKVPVLLSKLVFPYLKETKGNIINVSSCVSESLTPEATMYGIAKGTLDNFTKAASNEWGPAGIRVNSVSPGAVMTPLVTSLVGNNQDMIKKMAEMQGKLHALQRLGEPEEIAEGVAFLASDAASFVSGTVLFVDGGRHCFPGSVTGSKSGKSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB35</accession>
    <name>A0ABM0KB35_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xylan 1,4-beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113328.1">
        <property type="nucleotide sequence ID" value="XM_005113271.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853288"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF42">
        <property type="entry name" value="FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046176102" evidence="4">
        <location>
            <begin position="28"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="5">
        <location>
            <begin position="681"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005113328.1"/>
        </source>
    </evidence>
    <sequence length="775" mass="86595" checksum="470925CF273C7A71" modified="2025-10-08" version="1">MAMLSRILYSISILILAIDVSNHGVSSSRFDQRSHFNRVRHMYIEEDQRQFGDFPFRNTSLPWNERVDDLVSRLTLEEIQVQMARGGAGELGGPAPAIPRLGIGAYQWDTECLRGDVFAVENATGFPQAIGLAATFSREILHKVARATGQEVRAKYNDFVKRGIFATHSSASCFSPVINILRDPRWGRNQETYGEDPYMTGILAENFVKGIQGNDSRFIMTSAGCKHFDVHGGPENIPVSRFSFDAIVSDTDWRMTFLPAFKKCVEAGTYSVMCSFNKVNGVPACANKKLLTDILRTEWNFKGYVVSDQGAIENVILTHKYCNNSVDTVATCINAGMNLELSNDIPRPVYLSMIDAIQQRKLSEDLVRERIKPLFFTRMRLGEFDPVKDNPYAQLGMDQVESAEHQQLAVTAAMKSFVLLKNQGSILPLQKGEFSKVAIIGPMANDFEQQIGEYQPFQDRSFSTTPLDAVRSLYPNAKYGQVCNDSTPCTQYNKAAVPPIVKDTELVFVALGTGQAVEREGHDRPDVELAGHQKELLLDVLDNSGDAKIILLLFSGSPLNITFADQSDRVIAIMECFFPAQSTGKALYNVLTNTGPYSSPAGRLPNTWPLYSTQIPPMVNYSMEGRTYRYFRGDPLYPFGYGLSYTQFNFSNLIYNTTIKAGDNLEVQVDITNVGNVDGEEVLQCYISWNDKSLPVPQLQLAYFDRILITSMQTVSRRFSIFSESMAFWQDGKWVIKAGGLSLFCGGQQPHQKKQVPSNVLRGTFTITNSITLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBH0</accession>
    <name>A0ABM0KBH0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prosaposin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113565.1">
        <property type="nucleotide sequence ID" value="XM_005113508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856867"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008373">
        <property type="entry name" value="Saposin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01797">
        <property type="entry name" value="SAPOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="93"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="180"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005113565.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34029" checksum="0E1AED4AD675A7B2" modified="2025-10-08" version="1">SKPVKAGPYCALCELVMTQLDQMLQQNSTVQEIESALEQVCNFLPATMRQECDDFVKQYTPTLVQLLLQVSPDKACSYLGLCTSNKVSKPVKAGPYCALCELVMTQLDKMLQQNSTVPEIEAALVQVCNFLPATVRQECDDFVLQYTPTLVQLLLQVSPDKACSYLGLCTSNKVSKPVKAGPYCALCELVMTQLDKMLQQNSTVQEIESALEQVCNFLPATVRQECDDFVKQYTPTLVQLLLQVSPDKACSYLGLCTSNKVSKPVKAGPYCALCELVMTQLDKMLQQNSTVQEIESALEQVCNFLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUW1</accession>
    <name>A0ABM0ZUW1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101862632</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101862632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934945.1">
        <property type="nucleotide sequence ID" value="XM_013079491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862632"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012934945.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="34761" checksum="D0464DC251A1AEA6" modified="2025-10-08" version="1">MADAEGCYSDTEKNDMLNLVNSNPPQYATACDMFAHRLQCLDRISHDCDAVRAQFNEFRATVTSDFQGICEQNGEVAQCAQKAYACREEYNETSTVLKQHNITKACSLGEDFGDCIDSAFSSCPEKVKDHLEDQKNNIYLEEMLTGCDGACGKAMSSCFRTVESTFRQKPVRNNTLCPYTNVALTCAVKLNQTDCASNKTFFDSIMSVWNKRISDFCPARSDCNKRSSGCLDKLNGAEGLAQTDKAAYCQKVSATNTCLSSIKNNQACALYSAEDLAIVKNFRVTTKPVCDGASSVEQNSFLLCLLGVLYIMFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV32</accession>
    <name>A0ABM0ZV32_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101858390</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_013079610.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="chain" id="PRO_5047515770" evidence="2">
        <location>
            <begin position="20"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935064.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19774" checksum="D755056EEFDC16DD" modified="2025-10-08" version="1">MKVISVILATCLALAAAHSQKKRQDAPPAVTNPPAMMTTDMVNGTDMMGGNDSTTAPTMAPVTTPPPAPPAVNTSKPTDTTTMSTSAPVTNAPMPTKIVSVEEIVEVFEAVSKTDYFKRLSYEDQLLVMEILSGGETGKMTPILEQIGFEHLLNFMYELPLKYVDDFNTFVNQGFVREHSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWN8</accession>
    <name>A0ABM0ZWN8_APLCA</name>
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        <submittedName>
            <fullName evidence="7">PHD finger protein 20-like protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20104">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856:SF51">
        <property type="entry name" value="MBD-R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856">
        <property type="entry name" value="PHD FINGER PROTEIN 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012936055.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="43061" checksum="CBABE4015FE30AD6" modified="2025-10-08" version="1">MDGEEAPADVGLQQFSPHALSEDSSVSSDVESLPVHADVSNPESFPVSESMSNVDVTGSPSAVSSSSSSVAAVRDEAAPGTPQKGMAVSRTGSTSGLVTTPPRTLLSRFPLRVGITWKKGEKLEAMDYSRTWYPSKIVDLDEKDQLVLIHFEGWNHRYDEWLPMGSDKLRPVTRHSERKDRGIKKRRAYPHPVSDPPAIYRAGERVLAKWTDCKKYPAKVNRLMDDGSYEVIFYDGISRLIQPINIQPLPEGMGETAAPQRSPQKVAAPAAAQPKVSSGFKNIALKLPESVTQKLSRPSVLTKKKFPPTKGFPQPRFSPVKSEVAGQEPSTGQLASEVAPSVSEEESSSQARGKRASSQGEEVHSWAVRYVPICFVFHSMISSVSCSNMLRPKC</sequence>
</entry>
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    <accession>A0ABM0ZX05</accession>
    <name>A0ABM0ZX05_APLCA</name>
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        <submittedName>
            <fullName evidence="11">Leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106011386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Tectipleura</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936245.1">
        <property type="nucleotide sequence ID" value="XM_013080791.2"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
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        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF12">
        <property type="entry name" value="KEKKON 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047435146" evidence="8">
        <location>
            <begin position="32"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="298"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="390"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="543"/>
        </location>
    </feature>
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        <location>
            <begin position="390"/>
            <end position="401"/>
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    </feature>
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        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="422"/>
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        </location>
    </feature>
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        <location>
            <begin position="507"/>
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        </location>
    </feature>
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        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012936245.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="59584" checksum="CFD3FDD8814F209B" modified="2025-10-08" version="1">MMILQSTKPQVFAVLAIILSTILAFTPHVNGQCPAQCQCHDLNGHSVICSLSDVSSIPSGLAASTVRLTIMGQGAAKFSLSSLSRADFNGLVNLVSLKISFTELTTVSEDSFIDLVNLTRIDLSNNRISTILPNTFASLRKLTHIFLSNNPGAKIEDRAFWNVPSLREVYLGGLGLTELHPNMFYNLNSLTKLDLSANQLTSFPADFLAHMPTLRSLDLSYNNLTYLKDDLAPYFGKLQRVWLGGNQWRCNCLITWLKKYPHAVAAGKTDALTCAGPPALQHQHLMDVEESLLKCEPPALKDCPLKVTSEEGGTVGIRCLVTGEPYPNVTWTFVEGTQMTSDRINDVPSDWVAVHVDSIPLSYDGILVVTAVNNVGNDTCKIEVDVHPPHTTTVATTNPTPDSSKKPSTRTSLTSIVTRSTSPVGLSASSSLSPLSSNNPAVLSPSSPGNRAVSSSSLPQPAPAQSSPAEDNAHVIALAAVFGTAALILASVLTVFGVKKLTSLSSQTRISVTPDSQQRRKSLSSTPELTDMTNIPGTPQALRPGMAAKGAMAFLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY88</accession>
    <name>A0ABM0ZY88_APLCA</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101852468</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936981.1">
        <property type="nucleotide sequence ID" value="XM_013081527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852468"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046961240" evidence="3">
        <location>
            <begin position="25"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="4">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012936981.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="59497" checksum="5CEF9E5B55F1EBE4" modified="2025-10-08" version="1">MVSGMQVLLVLVVLVTLGKNGLLGDQGMGVPHTEHKETDLAAQNYSTTSELENGTMPSTEHSELSTKSPDVKFSNTCRNWCGRERELQLKQNLCSCDTLCRLYNSCCWDFETTCPTIDKTGRALVSEDLLAATIVCDEKSGVYVVSECPPGREIIEPTERGSAYDLQSLIFVTDVSTLVVYKNEDIFRCFNPGKDFLMEPWGVTFDTRDLPAVGTETTEELWSILKDRDRTVVPPPASYKGRKCDLLLSSVFPFSVTMRMTESGQMQFSRVREGKVGWSVLQCIGNACAQEQCLQPNAALIFGGRCTYTFLVTVSFTLRSALDCEENSGEGCMPLNSEKIATKVPLFASAIQCEILQRAVGVQKVTIQKIDQEIADDISEPEFIGVNKISAGHLAIYTFSWSVVGSDTILNELTKEMVLEMVSEHLHGLGLLPQKSVAQSKRVGEPRLDNASLPWGQQEMKCDLGYACVSIATGEESKLPCSALSHCLYKPKFNVNSFAECRSKLWRNSATVLDIRTFLNNVLSLMAIFSGHSLFTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZL5</accession>
    <name>A0ABM0ZZL5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937801.1">
        <property type="nucleotide sequence ID" value="XM_013082347.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011730"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937801.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="50662" checksum="244D71238E21B434" modified="2025-10-08" version="1">MSRDWPGVSEGGMFPDDASTVHIPPSLLVASDNRCRFGVRWYGGGLRCYCDSDGSITCGDPSFVAARIDGFRFEKVACEQGHIWEEKGSCRVCECQISGVVLCRRSSHCPLPFLIQPVSVDNSGRDATEGGGDYYIRSQNRKHNGAFTGEFRSGQEDSLDWSHVTSRGRGTVGGGLAQVTGHRIGGDVRSDVDDTEDDVDFRILTSGEMDGSGETTTSRESTPDRSDIIGGGARREETGSDIVFDLTLDPSDRPSIVVDGGEGEGRGGLLLTGGKIPDPDAKDYTISSNHNRNNNKKKSNSNNNSNKYDHRKQYDKQHRDVINNSMGLPQQGGKRRTTVVIVRECKPRSRWLDGCRRCRCDVRGRKYCDDSSCLKAELATVETSTAASSPQDGGHGGKRHARPMQRPPSLSIFRNEPVNLTDRFRPRNHCGRFKVNQKYWSDCNLCLCTPHGPKCTAKNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3B1</accession>
    <name>A0ABM1A3B1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mismatch repair endonuclease PMS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939969.1">
        <property type="nucleotide sequence ID" value="XM_013084515.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850344"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="228"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="739"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="585"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012939969.1"/>
        </source>
    </evidence>
    <sequence length="922" mass="101762" checksum="BEEBDAE9D364B378" modified="2025-10-08" version="1">MSTEEVSECRKEATSIQAIDKGSVHRICSGQVVLTLATAVKELVENSIDAGATSVEVKLKDYGSESIEVTDNGAGVEEVNFEGLTLKHHTSKLQDFEDLINVSTFGFRGEALSSLCALSNMVISTRHKAADIGTRLEFDLNGRIVSQKSTPRQIGTSVVVQNIFHTLPVRHKEFTRNLKKEFARLVQVLNAYCIVNTGVRITCSNQTTKGSRSTIVSTNGNSSMKDNIANVFGPKQLNSLLEFSQVEPDESTCSDFGLKVQQLSSANFRLEGFVSKCEHGQGRSTSDRQFIFINKRPCDAVKIVKLVNEVYHMYNRHQNPFISLNISMSKESVDVNVTPDKRQIFVEGERRLLAVIKSSLIQMFEPTTSVYKMHNVLAPQLTVSPKVGVPGQEDSPDQRSSLAKLSALSKVHSYPPSNPSQGDNGTDTLSKLKRSFSSAFARNESAVAASPSRAPKSSKMASLEMNKSSSLPSRFGSSNETGSITQFLSRYSPKKKEPKTDSRDSDESRSSKMCSPVCSAGTELDPEGTGGNDNVILVESDRKSFGSSTNTDVDNEIKCSEIEERSSVDGFPSCAVPERGVKLSVSLEEESQSQSNKAINEQLGGSEKSESISSSLPSEDMPATACSGEETAEADSAVCEDDLKEDVSDVSPHAPQQEGPCVTVISMDEQEDRQGQKEKTISFSMSSLRQKMLKKKLTDTSLSGSHRSFRAKICPGDNKSAEEELQKEISKDMFSRMEVLGQFNLGFIIAKLGVDLFIVDQHATDEKYNFEMLQRHTVLQSQKMILPQCLELTASNETILVDNLEVFKKNGFDFLIKPEAPPTERVQLISAPVSKNWTFGKDDIEELLFMLMDSPNVMCRPTRVRMMFASRACRKSIMIGTALKKSEMKRLVTHMGEIEQPWSCPHGRPTMRHLFNMDMLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3I4</accession>
    <name>A0ABM1A3I4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940092.1">
        <property type="nucleotide sequence ID" value="XM_013084638.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012259"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012940092.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13793" checksum="D0D3DC8DBF14FF2F" modified="2025-10-08" version="1">MRVRDESYVSSTVINDTNGEALHKQKEIIKRCEEYFQELLNPPGVQAQNTQYPFTVNYPEHSERTILESEVKKALKTSPKNKAAGDDGITSEATLACGETRIHWLTIIFLKAWKERKVPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A427</accession>
    <name>A0ABM1A427_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein FAN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101851282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940404.1">
        <property type="nucleotide sequence ID" value="XM_013084950.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851282"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="280"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="629"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="713"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="761"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="884"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012940404.1"/>
        </source>
    </evidence>
    <sequence length="918" mass="104809" checksum="33E8BA81FA443AA8" modified="2025-10-08" version="1">MAFLETDTLGQERFSLLLLEPGEIYYEDFSVYYYPSGLSQEQAISRRQRGHLKLCSKSIVFVPKEIQFPILKLPLKFVQDIDEWSGGLFTKVERVIKITADQTVEMKEKNIITPFIFKKEECQHIFSLNYASVDDCLPQMCQVLRASTLPPGDQQAMLNAIMLSRQSRVKFNTSWLEDIYEKIILETRGDRITPLATNPGRIMLTSSRLYFQPFNNIDKWPVLKLRLKDIKRLICRRFLLRQLGLEIYCGGTAPVTHLYLAFNTEESRNQLYEEILSLPDLSLEDTGQEDMTLKWQSGVISNYDYLLYLNSLADRSFNDLSQYPVMPWVIQDYTSSQLDLKDESVYRDLSKPIGALNEDRLERIKERLPDLPEPKFLYGSHYSSPGYVLFYLARIAPEYVLCLQNGKFDHPDRMFNNLYDTWNNVLTGASDFKELIPEFFSDCGDFLTHRGIINFGFRNDGRPVGDVELPPWAKSSSEFVSILRQALESDIVSKSIHLWIDLIFGWRQRGEEAWEADNVFYHLTYEGAVDLYSIKDEAERRSLETQIMEFGQTPKQLFKSPHPQRFTSQSVPKFLSVDNAPRPIETSPVKEVSSLPGLDNLAAVEPKVDKMPQPKSVLDLNKLRSHLQYTLHKDAVTEVRMSPDGLSTFSVSQDSFLKMYSLEEQRQLRSVNMSLMALSSCEVMEDNKTIVVGSWDNKVYFYSIEYGRVLDTLHAHDDAVSCVRWKASKLFTASWDSTVKVWEMDFSNTQSGLPNPDYVGQLDHDEGVTCMDIDDECVVMVTGTKDGQVALWDLSHFYTVATMSVHSSPVLTCLLSSDKRRIFCSGSDRLLKVIDVETMTEIFTKDLTHEICCMTRMGGLLLTGDAGGQLAVWDMDVGQVTQTLKAHQGPVTCVDASHAGTLLTGGSDRTVMLWKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4X3</accession>
    <name>A0ABM1A4X3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101861219</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940900.1">
        <property type="nucleotide sequence ID" value="XM_013085446.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861219"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940900.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="53319" checksum="2887AC0CBE436C52" modified="2025-10-08" version="1">MLHPGAATPSMHGMGVPPHLPTVLPPHMTDLRPPDSAVAAAAMLNAPSAPSRHCSNCQLDPNPGGPCVPGWGVEGVPGSIKTADGLMVPYPVQEESLEDLNSRKKEIICHMQEEPMFMGYTGVAYRADGFRGGLDGLKTVLGNNKRMREAMPKLVSDMFVATRSTQSLDELLNEDTLSLVKWSSGDEPPRDVCTRGDFPERAPVARSVPESGRPLNAAPFSPAEGTVEHAAGGRKLYSSLEASSDQLYRPHFSHDAFTESEFSQFPGDDGDENFIPLEHTSVSKFGPISRMAKAKTDNVAPVQVTADSCKKMTPVLAVTPLERPLSSSTQRPSRFNRLNVLDAEPSVKPTPSEKPSIWQQSPCPSYQNIAMLKAGAAEAVTNNERLAYELQAVELEISMKTGKMPEPVGKIIQESVMYSPSRSSPDYPRSSSTALMAPLAYDRGQNVNSLMGRGHVTECFSLMSSAESLVSPQKAAESVLEDFYRSRHNVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A511</accession>
    <name>A0ABM1A511_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012461</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940957.1">
        <property type="nucleotide sequence ID" value="XM_013085503.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012461"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046023942" evidence="1">
        <location>
            <begin position="21"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940957.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36355" checksum="4803A3C78883D152" modified="2025-10-08" version="1">MKVFLLFAVLFAWDQCMVQCDLGPLGDPVPDSLPVTCPRCDKDHSVPGCLDHEHTCHHDEVCAIKYGSDHRPEFHCREAKDCLHDISHPLRNCTGGGVEVKLGHCQRCCADDSCVNFLAGLLKAEANVNGVSDDAVFCPGDCLEGDLQTCVDRGRTCDRDEFCRVKHDDHEVKGECKHDGDFRHCQDELRDHECGVPNHHGHYPDECYSDCCNTRQCLDTHFGAYFTTTTAAPTTTQPPPTVPTTTQPPPIAPTFIIDLIVPSGSAGSTTPSNTQNCMDQLAGDGCKDLMKCQVRLAPTKRTRKRNTQTNQALPLPLSIFFLGSCITLSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A829</accession>
    <name>A0ABM1A829_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium-coupled monocarboxylate transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC106012896</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942630.1">
        <property type="nucleotide sequence ID" value="XM_013087176.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012896"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012942630.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="37107" checksum="2439DB1F762A9A3B" modified="2025-10-08" version="1">MASTEPTVKTFSVADYVVFVITLVISAGIGIFFAVKKGGQKSTKQFLMADKSMGFFPLSLSVLASFFSASTLLGTPAEIYQFGTMYWISVFGAVFAPLTGALLFGPMFYKLKVVSVFQDLAKRTSVSSMLNSLAAVTWEDFLKPSVCTDLSDVTATRVNKALAVTYGCVGLGLAFLVQRLGGTVLQGALVGGMFGLVCSLWLSVGAYVTKPINFKLPTTTIGCNTTVNFSTVISLAQTPEYANFSFPTTFDLEGVENLYGLSYLWFSAIGIVVCVLVGFVVSLITGGTKAHEVDPSLQLRLFHKIRTSSCRCCPGPHNKHTARTELQVSHLWTPAEHDTEPKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9E4</accession>
    <name>A0ABM1A9E4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neuronal acetylcholine receptor subunit alpha-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101846458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943343.1">
        <property type="nucleotide sequence ID" value="XM_013087889.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846458"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046371747" evidence="4">
        <location>
            <begin position="26"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="5">
        <location>
            <begin position="78"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="5">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012943343.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25781" checksum="0FE1F50E73E8C893" modified="2025-10-08" version="1">MRAAVNALCVIFVCCCCYWMIPCQAEFVNMSMAKDYLYGGPDVDLFWPGEEENRKDEEAVKEGNNEEEEEPERVESDEQRLMRRLVSGYDNSVRPVYQAQEPVDVLLGLTLTQILDLDEKNQVLTTNVWLEASCVDDYTQGYMPSLAMVYDDSRVFWGPVIRFRSSCKIDITFFPFDTQMCRLKMGSWAYTGEQARAFVGGSVMVWGGITEAGKNTLVTVREFEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAE3</accession>
    <name>A0ABM1AAE3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SPRY domain-containing SOCS box protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943922.1">
        <property type="nucleotide sequence ID" value="XM_013088468.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860367"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03718">
        <property type="entry name" value="SOCS_SSB1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="56"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="243"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012943922.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33468" checksum="95294863E47FA7D1" modified="2025-10-08" version="1">MYVCFQTLANIGGVREQRMNMGQKVSGGIKTISSAREPTYKAINREPAYSPDFQKPSRLDALLDMPSCSREQQIKHAWNADDRSLNIFVKDDDQMTFHRHPVAQSTDCIRGRFGYTRGLHVWEIFWSTRQRGTHAVVGVATSDAPLHCVGYQSLVGSSKDSWGWDLGRNKLYYDMKNTPGVTYPTLLNSDENFVVPDSFLVVLDMDEGTLSFVVDGQYLGVAFRGLKGKKLYPIVSAVWGHCEITMKYIGGLDPEPLPLMDICRRTIRAQLGKHRLQETHSLPIPTSLKQYLLYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABL2</accession>
    <name>A0ABM1ABL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Treslin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944574.1">
        <property type="nucleotide sequence ID" value="XM_013089120.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849516"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026153">
        <property type="entry name" value="Treslin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053919">
        <property type="entry name" value="Treslin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053920">
        <property type="entry name" value="Treslin_STD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21556">
        <property type="entry name" value="TRESLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21556:SF2">
        <property type="entry name" value="TRESLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21854">
        <property type="entry name" value="Treslin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21855">
        <property type="entry name" value="Treslin_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Treslin N-terminal" evidence="2">
        <location>
            <begin position="67"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Treslin STD" evidence="3">
        <location>
            <begin position="632"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1431"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1389"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1431"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1479"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1496"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1590"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1688"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1744"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1799"/>
            <end position="1808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012944574.1"/>
        </source>
    </evidence>
    <sequence length="1808" mass="198015" checksum="E75B9B1A9BB8A1C9" modified="2025-10-08" version="1">MDEQLGKCKLVFLIDSSLANCQQGCRHLYEIVATTLRIISFFETSISKQRDDRLQDEGKFSKTNLHSAHVSWGYKLFNTTATLPRKTASVSNPDFQSRKYKHVEDFVTKLQGAFDDVIKDFSKRRSLSKPAELLSVALTEILHDFSWDSLDLVSTKVTVSSTSRTRRKSSQSFAEDVFHCGVVENAVFILSKAPRNKKSFRWFSNKMVIDSDVFIDSFMSPALQQAYKNKTISLSWIDVGSPQCGMGMDIPQGVPTQDSVLILRDAMRKLGGFLSQQSFFMQDSPPEVSRHNCWDATGLGHALSVQAHLSSLTARSRQRSTELKEIFIDVHGCTATYSIMPVSHRTLQGSAPRDPSLNDSIRRLDQLTVLGCLPKSYCDRNLVSNLCPTHIVYSKTPEKLSTLIKELFLSRSCAILRTQTSCLAILSPCTSNIASLSLVGTQYLVKTKLTPILRLNESFQHQASNTTAGKSAPVKDEHFFRACSLNSWYVPGSAAQLRHTVDKISERLDGHDQPCSQKSVLKDLRKFYAREKQPPELVHNPAPAATSTPLFGPTSARPSHSGGSDSTSQSRSRLSRLTRGRLMVDRAKSASLLMADDLDSSLSSKAESPDRRASSSFGGSCGLLELNLKTEEDLSQYLRKQYDQVVNAGIAMETTVQTMVTLTSRLMADLQHSNPQKSAVAFIREHLLLTSFKLKEKYSCKATDEALTGKLSEYKLQILLLLELESLLLENSVAAQEELTSELVSMLRVVSFSIGPAGLQEFLKDNVLANYHTNLAKVLVDVYDELMLPLPSILEKFASPSAPSSVWGAVPSVGEDSMLSGPGSSQPRSNMSDQALRSRSGKLKAHPSFSDFGQKRQILVKPKVAPKTSKSEKKKGSKDVSKAKSRESKRRPGVDHDRAKKNLFSDTPQQSKLKSRSRSRHRKHTSSSGQSRLLVPGTPAHKQTSSRIRAQQERRRQKHNVKTDVVVVAESPVKDDGKPVSQMDKPAQYLVREAFYSSSSQPSRNLAKSLELAQSSSHANVSSHSYLRSSQRAQGSLASAVRGESPLLSPGGRLMKSLMASPSPDRKAKHTYRSPSTPVRRSPRKSVKKLDFKDCAGDVRRTPGASSSSLDAHLIFDGENATDSNLFKSPEKRKYVPQSPFRTPEKSKSPFSHVSMGAASCPPAQSTPPKRPRQNLLSQELNFKNVLSAQNGNGGTPLTACDPAHSTGSETPKRKSHSSRLSGGDPNVSAESPTKAVLLSSPDWASRFGSNMVLRSPAKRLQLMSDSAKGVIHHCSEGESPRRLSNPSEKIRGSHGSSPRKERRVLHSKDRSFVGEVDDPHIPTSTPEKLSKLQTRHLSTPSKVKFSNRGFISPPTGSGYPPSAEKSTPGKSILKSPGLKLKQGRRVELVSLGSSSSGKHSNFMEKLNASTVDSSILGNSVQKSITQDNVANTTDHGVSSTHLSASSQSFDVASSKSSRSLSKSTLRRQSSSDDDSSDLFNTSAQESATIKIRTPSPASKTKTPDSINKWMRRKRLSGSKHSSSSSSGPSSSQSSSSSTEEKVKSSNKGNIEQKSVPELTEPQSRKRNRPQLENEIVSESPRKRVRRILNPKDEENSKENAFVERKGTSDFDPLFKVDIISNDGDNDVFPVGKQMASDVSLSRQPSLISKPSADTALSFFHQPLYSPIGTSSCEWYEGGSQGFPVSHTETDKKKADSCADKEVSKDIHEGGENVAGPSGRSPGSVTESVVCDKASQQMPKKASGHSNSSGSPIRSSFSTSPSDKKQYSPSLSASGLLHLIKSPLLSDREVRSKQVNTRAKSRKHLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABX4</accession>
    <name>A0ABM1ABX4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deubiquitinase OTUD6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944763.1">
        <property type="nucleotide sequence ID" value="XM_013089309.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860209"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22761">
        <property type="entry name" value="OTU_OTUD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049772">
        <property type="entry name" value="OTU_OTUD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="177"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012944763.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37369" checksum="6EAB6DB41921B3BD" modified="2025-10-08" version="1">MAARAGDEFEDSKESPAFLLDEEGLLAKHRKEKKELQVKVQKLKNSVPKGDKRKKKEVSDEISKLEQDLQKQQKQELEEFRDGQKGAQEEADSGNDKVNVEDEVTVSEDTEVPLGEKDTADQTQANRKSKAQKRRDKKQAKGKEREERIKEQAVLNCQAPRHLEMVTLKAALKLRGLALHEIAADGNCMYNAVNHQLSCRNLESSNKELREKTADFMRSHRDDFLPFLTHPDTGDMLTEEQFEEYCEKTSKTPMWGGQIELRALSEVLQVPIEVIQADTQPLVIGESMKADPLTLVYHRHVYRLGEHYNSVCPLTAQEEEAEEESGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABY9</accession>
    <name>A0ABM1ABY9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Ecdysone-induced protein 74EF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC106013475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944791.1">
        <property type="nucleotide sequence ID" value="XM_013089337.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944794.1">
        <property type="nucleotide sequence ID" value="XM_013089340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013475"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF191">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="413"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012944791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012944794.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="56409" checksum="062F9E680FAA12E2" modified="2025-10-08" version="1">MESLEESGQGPQIGADPFLTDTCDVRSLTQHENYPAVIVLPQPSDFVELLSERVHVLDSDSLELVMHNKSSSGFRPVDISPMDTHKLFPDSGAESDDSGIHSFSDVNFFTRRRSFFDEDDVLENNVYLDFNELTVPKDMDGDRDELRSDDEDNSDDDSHSSSGSSDDSSSGSSSDEMDDDEEEEHEEVDACEQQQDGRGREMAVEALLSMDSPSTGAEGKTFLQGILHEQQQQQQQHTTATASSSSSPPSSSHHHPHHASLPPSPDSGLDSELDSSSTDDVKHRHAGNGSKAPPGSFVAPFCQPPPAHQPLPAHFNTATHVAMRPDHFDSSPSLQPLTAVQANIEPYHKSSSLKHNSNSAASTKLSSTPPFPQPSPAASEEKPKAKKGRKPKYAESDCQYATPAKRKREGNAQYLWEFLLQLLQNQDTCPHYIKWTNREKGIFKLVDSKAVSRLWGQHKNKPDMNYETMGRALRYYYARGILNKVDGQRLVYQFAEVPKNIVEIDCSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC74</accession>
    <name>A0ABM1AC74_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosaminoglycan xylosylkinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944924.2">
        <property type="nucleotide sequence ID" value="XM_013089470.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859823"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF14">
        <property type="entry name" value="GLYCOSAMINOGLYCAN XYLOSYLKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM20 C-terminal" evidence="6">
        <location>
            <begin position="98"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012944924.2"/>
        </source>
    </evidence>
    <sequence length="311" mass="35355" checksum="B077FD404A2A6357" modified="2025-10-08" version="1">MARGNITLADFGVKGTQLKLTLTLDHKQKVVFKPAWYGRDDIITGTPYSGRDRHNAEIAAFHLGRILELRRTPLAIGRRVDIHRDIKPVATERLLNTFFEKDGQTCFYGKCLYCRGPDDGVCATTAGVMEGTLVLWLPNDFKLKLHKHPWSRTYKEGVVARWMKEDDYCDKMRRIARFSKGPRLLDIIDTSIFDYLIGNADRHHYETFEGYDDSMLIILDNGKSFGNPDLDERTILAPLYQCCQIRASTWQRLLALQDDVLSQVLAGVLANDPIAPVLSQRHLDALDRRLVYILDVIQGCITRVGMGAIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACC0</accession>
    <name>A0ABM1ACC0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944994.1">
        <property type="nucleotide sequence ID" value="XM_013089540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013540"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944994.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25858" checksum="96C05822E5D30445" modified="2025-10-08" version="1">MGGTRKGGPEENTRFSGRDEFGAGAGAGERGFRGDDERGPPPGIGRRDRSRSRERRRRSRSKERPRRSRSRERRRSRSRERRRSRERGERPDAEAIGPEEEEAMGRREKKRRRSRSRDRERRRSRSRDRKRGKRSRSREKKYKIKEEALLEAAQYVGGPGGGGGEGDGMNGAGAPAYGDPGYEDVRVKEEKADAYAGYGGPNPPPGVSLMMERGPQGVDEEEEEEGEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACP4</accession>
    <name>A0ABM1ACP4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101859526</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945171.1">
        <property type="nucleotide sequence ID" value="XM_013089717.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859526"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945171.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26197" checksum="1AD1B14D18CE6F6B" modified="2025-10-08" version="1">MPQNSPLKQNHFRVQLTPPVPWINPAGWSAHSVPVPSFSDIGHQLAENMAPEPAGKRRRIESEPSPNGVESRFSGSGLRPFSSSQSRSAGDISGGYDHVSKMPMETQLWFRLREQALREKRDNLLHNGTVETGAVDWEKVQAVTAPVFSLVGAFVANFQEEFYTDRFSLEERVFLKHLCTECKIETTDQLCNNDSVVTLRKTSETLFPTEQVFQRVLMTLQQSQTMVGLGQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACP6</accession>
    <name>A0ABM1ACP6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ecto-NOX disulfide-thiol exchanger 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101863631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945174.1">
        <property type="nucleotide sequence ID" value="XM_013089720.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863631"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038876">
        <property type="entry name" value="ENOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056611">
        <property type="entry name" value="ENOX1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF4">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23267">
        <property type="entry name" value="ENOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="166"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="452"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012945174.1"/>
        </source>
    </evidence>
    <sequence length="655" mass="72697" checksum="B5F07E151FD71B5B" modified="2025-10-08" version="1">MDPSRNNMPLQFNTNKNKPPMPLVRTNSDTKDDDVSSSTNQGLMAVPDGGGGGEQGMMGVFNMMGQMVGPMAADPNMMMMGPMNFNNQFGGMMGPGPSTMMGAGPMGGMGPIGGPMGGPGMMGPAPGMMGHPMPVKEVIRLKSSVLYPPPMGAPPRSTRERPLGCRTIFIGGIPENCTEDILFEVFENCGIIQSIRISKKNFAHIRFETMDSVDRALYISGYRMKIKDSEEKEDTGRIHVDFAQARDDQYEYECQQRALAREMRHMQRLEEERQRPASPSPITHYSDHEGSLLLEKLKSDENFGKVSQCLITWLERGECNRRTATQFYSMVQNVHGHVRRLNSEKETVEAEYEQYKIQYQQRLVAIRSQLCQVERVLGAAHKQKCWDHFTKAQRKNIDSWQRQAQEERESQVLEQQGRSEDSDDMDMSDEEGPSPGKKSKTDSQFDLGLAESQRLKEENDALKCQMEAFKNEVDTVRQEARQEMDDKEKQMKALQNALQGMQQQLIAQRAAAAAAAAAAAAATATASQNTERREEVTEKQREGTNKEDEGTGSGSSSGSKEETVTSSALSLTEKEAKMIGLICCFLHVHPHGATVDYLWSYLRQLMAGVRAREVEDLLEKTPALFQQEIRGVGAGIERRWIFSGLSAGSAGGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD25</accession>
    <name>A0ABM1AD25_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leukocyte receptor cluster member 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945387.1">
        <property type="nucleotide sequence ID" value="XM_013089933.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862091"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945387.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40160" checksum="CB37506766A421AE" modified="2025-10-08" version="1">MNILPHKSWHVRTKKNIERVRRDEEKAAEEEKERQRRIALAEQEARTDLLRARAHGRALKGNDSSLPPPPVESGTAEETSAQPGALDVFAPRSSGRDVAVPGLGSKTEHVNFFKDIEDGLCKQGKNKEHEAEKKKEQEALEKKIGLLTYLGQTALDEKEAPPWYMKKSHKKKKKRKSESESEEEEEDKEKKLKLALEEHRRRSLDPLLEMREIMSKSKKKHKKHKTKERGKDHRSRSFPSKSSSSKRSSSPVRTGASQVASSSSSSSSKKTIEQLRAERMARERQEKARAQVLVNKHKDGGDKGSKEKEESSSDSEDEREKGQSGKRRYNSQYNPEFISSQPRKRRRNALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADI4</accession>
    <name>A0ABM1ADI4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945614.2">
        <property type="nucleotide sequence ID" value="XM_013090160.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848159"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
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        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945614.2"/>
        </source>
    </evidence>
    <sequence length="172" mass="19537" checksum="F414A41E5473273B" modified="2025-10-08" version="1">MKSTHLADTKTSRYLGVAGIEEAEDFTPLSDKDLQTSVSNDINTTLEKGEMGRLFAIVYIRGMQYKVTPEDIIVVKNDFPPNVGDKIRLEKVMAVGGRDFSLFGQPLLSRSVVKVEATVVEKTLTHNRVWYVFTRKKNTKTFHLYRERQTMLVINSIQVAQLPQEEEEGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AED7</accession>
    <name>A0ABM1AED7_APLCA</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101864585</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946079.1">
        <property type="nucleotide sequence ID" value="XM_013090625.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864585"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946079.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27616" checksum="65E10D4399779EA5" modified="2025-10-08" version="1">MLFWRKFINKYLLPIKPSPEEKKNIADELRELRNNSSFGLIIINLLWMAVNFMFQFTTAAKVTIPTGHSSGAVEESALGLSFVGLLLILLLTQVIGMLIHRLGTLQHLLAITEIKIRRSSGHHQEDGEDTSIQDAIRHIKDVLRMPAEDDPGAVTEAPEIADEGTAFGETVVGASTRRLPFDESQRLSQTIKRIGSLLDARRFNQTLDRNTSETLNTVRRRLTGENHRENLGLSKRPELPPRPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEZ2</accession>
    <name>A0ABM1AEZ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106013978</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106013978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946398.1">
        <property type="nucleotide sequence ID" value="XM_013090944.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013978"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012946398.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11960" checksum="2F2937AA09978047" modified="2025-10-08" version="1">MELRVSRLLGRVVLLLVSGILAVSVISGEVKEFAKGKKVSLFYRHHDCVVTYFHNGLVVNSTLDSQGEHYHRVTARLQAFGRLFVLDLTLNRQLFSGSYIERVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF97</accession>
    <name>A0ABM1AF97_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Papilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101850775</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946540.1">
        <property type="nucleotide sequence ID" value="XM_013091086.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850775"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd22630">
        <property type="entry name" value="Kunitz_collagen_alpha6_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22637">
        <property type="entry name" value="Kunitz_papilin_mig6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938">
        <property type="entry name" value="ACP24A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938:SF11">
        <property type="entry name" value="WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047473988" evidence="11">
        <location>
            <begin position="29"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="560"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="913"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="972"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1065"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="16">
        <location>
            <begin position="1084"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="1306"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="1376"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="1442"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="1559"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="1682"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="1738"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="1817"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="1906"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="2003"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="2101"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="2201"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="15">
        <location>
            <begin position="2278"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1263"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1874"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1269"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012946540.1"/>
        </source>
    </evidence>
    <sequence length="2319" mass="254816" checksum="50BB1B8792718549" modified="2025-10-08" version="1">MASSKRIMGGVTALHLAAFLAGIALVLSQSEDGWGPWSDYSECSRTCGGGVQQSTRQCRVGRVGSPECQGHSIQYQSCNMEECPPGSLNFRAYQCSTYNSVEVAVEGKTQRYLWKPYYDPSSPCSLICKNEYGQLHTLRDSAVDGTWCDNGDSFGVCVAGFCKPVGCDHKLGSVRAEDRCLVCGGYGENCETITGTTLDQDLRTGDQTEITTIPLGATKISISITSTSPSALELTSAGGDTLKLTEALITFGQRKLADFAGTRFSYYYLDDGMKFTGRGPVNDTLRLLVRFMGLSPLVEYEYSIPKSRVQEADPEQRYSWVFGGWTSCSNECGVGYQLRAISCMDRELGRSVSPRLCPRQQMPDRNQTCNHGPCPNSLSDGYKWVPGHWGECSVDCGVGEQTQLMHCIETGVTGDSIYAEDDLCTRYVGAKPEYRRACQGEGESCAYWATGPWNECSVTCGYGRQQRRVYCQRDAARAGSVPQVMDDDHCSSESRPKDTEICTLDPCPDGSNTNIDLTPSNIVQDCRRSRFGCCPDRVTPAKGDNMFGCEDKRPARVDPCQMPSDRGTCSDYTIKWYFDVNEKECLRFWYGGCEGNGNRFDDRDSCRNQCLKKSIKPEGSSLTCEGSQYGCCADGRSYARGPNKDGCPEKNLIGGCAGTRHGCCEDGVTSARGPEKEGCPEKRLVGGCAGTRHGCCEDGVTSARGPEKEGCPERRLVGGCAGTRHGCCEDGVTSARGPEKEGCPERRLVGGCAGTRHGCCEDGVTSARGPEKEGCPEKRLVGGCAGTRHGCCEDGVTSARGPEKEGCPEKRLIGGCAGTRFGCCNDGVSAARGENNLGCAENPYGGCSVSEHGCCEDGVTMAKGPGREGCPETIAVASARSCEASTYGCCPDGVTDAQGPNEAGCSSFDHASCALAKNPGTCTDYKLKWYFHADFGMCRQFWYGGCEGNANRFESEEECRSRCIDVGGTDICRLPVVKGPCRARKRRFHYDAASGRCNSFFYGGCKGNKNNFNTQAQCENTCKNVDKTERQRCNKQCLNGGSLDQDSCTCQCTMSYTGEMCQNAIPRPCDSLPCQNGFTCQDYLNATYSCSCSPDWGQNCERPPTYWCFSDDECRGDMKCVRERECSSGYCNIYAKCTAPSVSYQCDRPRCPRNQDCVNDDSFEDGYFCVDKIEYRRQNDVVLGCDVSRFGCCRDRRTAASGPNYEGCRETPCEYTRYGCCRDRRTAAQGPDFEGCDDTVEGSAEVPCEETRYGCCSDGVTAASGPRGRGCEDTPDSEDRGGQSGAGSGGDVGKLEPTEGPMMEKCVAPKRRELCTKYEVKWRFDDVKQECERHWWGGCRDNGNVFDSQEECEVTCLKNVVITDPGTGDPDFVSICDMPQDTGPCRAYLQRYFYDPRERACNPFTFGGCGGNENNFMSLEECQKECMGVITPVVTTTQAPVPETLPPPVGGITLTISGENYVNEGTELKVACQSNDGSEEALTFYLDGNLVRPGRAQILQYKSVVDDRVVVVNELVIQRASPRDAGTYVCRSQSGELESLNVIVITRSVPTTTTTTEAPYVPVESSIAMNGSSVVSRGSEIRVVCRAQGSRRPSTIDWFINGRVVDDRNSVDSYADPRALNALISELTIRNAQEDHEGTYYCRSRPYGDLDKMVISVRDEPEVITRRPTEEITESSDPAVVCMMEKATGNCYASFPKWYYDHQAGECKEFTYGGCGGNSNNFQSEEQCNRFCTASDVCTQPKEIGRCRAAMPRFFYDSQTRSCRDFIYGGCGGNLNNFNSMEGCQRKCASYIQGRGNTGGANVRVVGGDTDTDENVCELRPEKGNCRGYNIVWYYSSARNRCARFVYTGCEGNGNRFDNEADCEVRCLRTQTARPRQRLTQRPRPPPTTTTESNIIPESRVTEGVCQQTKDGGNCADYVIKWYYDSQRKYCLRFYYGGCGGNENRFDTEEECESRCVNTAPATPRPYTTPRPRPVSCQYSRYGCCSDGITAAVDVQSSNCGETNVIVQPGEDDRTIVRVTRGADAFLKCTLTGQDVIWIKDGYTLAYDRRYQVFQNWTLALRSVSYDMAGYYACRSTYGFNQFPVVEKFKVEVNEPMNILPGPALVSVRPGESAYFHCQASGSPTPRLSWQREGRVLNSRGRMQVFGNGTLIIDDVEPRDTGMYECFAENGIVSPVRRKIELTLRESIQADIQQHQGSFMEGSAIRLFCQGNGYPQPQVEWVKEGSVMTSGGKVSVRGGELVIQSASIEDAGVYKCVVTNGRSQDEDVTTVHIKFHTPQAQCTDTMRATKCRLIVAGRLCGFRMFATKCCRSCRRAGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG27</accession>
    <name>A0ABM1AG27_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 74A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106014229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946947.1">
        <property type="nucleotide sequence ID" value="XM_013091493.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014229"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946947.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27888" checksum="2E7A4EA427AE40ED" modified="2025-10-08" version="1">MAGVDLRVPPRKTSRVVKCRTQQTQDGGALFLTQPEVTREGSILRLSTPSPPPDEDDLDQDVGNVRKPDVDEIKKRLYQRECTRLGVTPVGAFMREPTRSQLAIRHYSLGPRGAKALSVPLMLDSTLTSLDLEGNTIGADGMAEMVEMLCENCSITHLNLKRNKLCSRGASLVMRVLKSNRHIVSLNLAANQLVDIDGLTIADMLRETRTLKSLDLSDNALSFRSGKALGDVLSQNESLESLDLSWNQFRESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPU8</accession>
    <name>A0ABM1VPU8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein MTO1 homolog, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118477335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824440.1">
        <property type="nucleotide sequence ID" value="XM_035968547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477335"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MnmG N-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal N-terninal subdomain" evidence="6">
        <location>
            <begin position="502"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035824440.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="66001" checksum="4976141C2B056E28" modified="2025-10-08" version="1">MMMIKLKCRTSWSVCFALKRHLAHSGRAYYSNAAERKNENTFDVIVVGGGHAGTEAACASARMGVNTLLLTHKLSTIGEMSCNPSFGGIGKGHLMKEIDALGGVCARICDKSGVQYKMLNKKKGPAVWGPRAQIDRELYKRQVQEEVLATPNLTVRAAAVEDLVTQEGPSESGSSVQCCGVVLDSGEVIPSSTVVLTAGTFLRGSINIGLTQRPAGRIGDEPAVGLARTIEKAGFTMGRLKTGTPPRLDKRSIDFSCTEVKPGDERPMPFSFMNETVWIKPEDQLPCHMTRTTDQVAQVVRDTLHLNRHVQEEINGPRYCPSIESKILRFSQKTHQVWLEPEGLDSEVIYPQGMSCTMPEEHQLVMMRAIPGLENCRIVRPGYGVEYDFMDPRQLKPSLETRLVANLYFAGQINGTTGYEEAAAQGIMAGINAACQVQAKPPLVVSRTEGYIGVLIDDLTTHGTNEPYRMFTSRAEFRLSLRPDNADIRLTSKGYTVGCVSEERYQRMESMRQKLKENLELLADVKKPTNKWRTSLGLPATTDTNLMSAQSLLCNPLVSLSTLAQAWPSEFGHFLQADPHLLDRLDIEIKYSTDIASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSB9</accession>
    <name>A0ABM1VSB9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101860648</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825311.1">
        <property type="nucleotide sequence ID" value="XM_035969418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860648"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09527">
        <property type="entry name" value="SAM_Samd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058666">
        <property type="entry name" value="SASH1/NUB1_homeodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26285">
        <property type="entry name" value="SASH1_Homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="753"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="840"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="425"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="598"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="904"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1252"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1291"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="907"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1252"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1314"/>
            <end position="1329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035825311.1"/>
        </source>
    </evidence>
    <sequence length="1560" mass="168687" checksum="8966542EABC45340" modified="2025-10-08" version="1">MASSSSSNSIVEDWLRSVNLVQYTQSFMDNGYDDLEVCKQIGEDDLDAIGVSKEEHRERLLRAVKVLKEEGGTAVYFTLEECDTCQSGDETEVGEGNNDDETCSSSSAVAALALAEASGGGGAVVGGSSGAGVAGLGLGMHPAGSGYRVDAYDMGKTTLLSYPKVQLKLILRDRLVENGIDLASPPYTNSDMVVCGSSLTALAIRFAEELRTHFVDVLERLEELWLLARNNEGLYTGMCRSPSKSVYSGGSQSLHYGYPGYGPAHYLPHHPVHHPGSPHSQPPPLPSCPPPSTMSSTSMDRCTNLQAHLDGGHLRPADPYGQHQNYVALDGGVCCIFPRKIVKEPTGGSTTEEKKKSGSVFGRFLRNIGFRRSHRKGTYKQHQDLNAYEISMSDEDRMALMILVKEGKISTQTALAVVQKFEEEKRFGGSGTSEDGKENVCDTPSKKSGTGKKKKGGKPTKSLSTLSADEPTRGPAMPPTGEKTDMGTLCAHQVCRQRRVHSLGQLDSPHLCAQQEGPRDLHPGDRMALTRAVSCSPACTPSHKISYTPEHAAFGRLHSPSHHQQLPLQPHHLLHQPQYIQQHHHHLNKVDALRERLTGKPSAAVPKTSSKTSLLSSGSDQSMECGSQTPLRPDPMPRRAADVATYNSNSTVSMSSDTNSPAPGRKKSSGLVDPRLKCHRSASCSTGDDGISSENDEQDHLSRGHRKQDSQRHKHGHHSGKKPSLRVKEAIISRPPLLRQLSAPVGNMGLPSPYLGQAKVIVDYSPGPEEEEFIPLKKGEIVNIINMAQSGVWRGVVNGRQGKFRFEHVEVIIDPEGAAMSHRVQGQSSVLYGQKDIPTSVEDLLQKIGLQHLSNTFMVNGYDDLDIFSELDDHDLDTLHVTDPEQRTKLLSAAHVLTDWHEKMNVRTPTQMSMDSPSSRAGNSSCDSGCYAGGEGPKHQTRRRGGGGGRSLDRSSPAGYQPSPKPQRTPCRSCGKPKQPRKNSGPAAGVAHFMMGQPMMGHYAPNQPQYHSSHSPYAPGHYQMAPMSQYAHHSPAHSMHSMHPTHYTTGHGGYAPPPHMHMSASRTLTEISASDNSSATPKLQTFAIGKQNSAGVVAGQHSEQGGAYATYSEKGSIGDRVSLTEEDQEVIAITYGTTQGRKLSTPAQPLPSSSSQLDIGPAGVCSPYAPLSGCPQCDQYVFCDSASCSQCLAYTSCPQCVQYRHYVNTTMRSDSKSSKMSCSSTCTQTTCLSPDHEEGNAATATIIDYTPSPSESYYGQRTSPGRGPMTPHQVQHQHQLQAIMCTPNLSALHHSSGKPHTPDPQVPPSPAMSVKSQQLTLALADSTTPHGVAMSFPGDPPPPGASPSPAVWAGQADGTEAPGMATLYSRGKAQAQEKSEGKSEGGQVKSPTRSLMPLVSTKLNAERIDLTQMPYSNTIGHCGIPPLLVQRYAEELRQDMDTMALVLEQLREKHLRAQGRPYIQSESLSDSCKSACDLQISSIHEFLISIGLPMYQQSLTEGGILSLDHLLRVRETELEQMTGADSRHLKRVAHALEWVRHKLSSPSHKARASGGVTDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT40</accession>
    <name>A0ABM1VT40_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC101864142 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101864142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825582.1">
        <property type="nucleotide sequence ID" value="XM_035969689.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825583.1">
        <property type="nucleotide sequence ID" value="XM_035969690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864142"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="53"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="180"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="676"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1128"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1144"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1177"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035825582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825583.1"/>
        </source>
    </evidence>
    <sequence length="1218" mass="138466" checksum="10CCD3FA7D11DAA0" modified="2025-10-08" version="1">MQITDAWPSKRVNTMKYPSRLLVGCICLSLMFVTTSLVQANIVSSYLDPSKDCGWTYDNYITFGVLRMANPPSHNGSNVSCVFNLSTTPGSYFKLTINNFSLGGSDVCGENSEKVSVEFDQDPRVPQHWPDRISWCGKKRPDVMWLPSTVKIVYNTGLNGRGEGFEMTFEVISKDRQDFCDGFSRLQIDKKHGKLLYAPGYPFEMITPLKCNWTLTTSSGYGMVVRVLALGAKTDYRSCFKDYLKVGAKKFCDFVTFGTENIYIKEMSTTVELSISKFGFESGSQQEMVLDVSSVLKSSRCSDVYHYFSDIVLTEAVVLEMDKQSRKTSCEVRFDSGSDDKVIEYNLLAPSTMISLLCKRRFFSPSMIFYLEDDDGTVFNVCSFSMKVFRSSGRRLVFTLRRYRTYSFADIIASFQAVDKFPLPRLLLSSLSSAVHIPQAFLASEREREREIHLQLGLTPYIIENSRDAVTAIKIFNNNWTEELTPANMLKMFNGPNVDYFELTKDCNGDPRSEKTLYSKGTWLVTVQILADLIMPDGFWLVVLPVKFKPLYTNSLKNNVIELKKHALPFGKNLHCFWKVSNSSNTSIQSVKLVRSDDGVQYEISELLASGKRRNPPLIAAPSHNESQSYWIYSLHNIEVYVRILPDPTQTTRNEYFLAQYKVITSPASVAETSSCLGTELHAEQATKTASSPSYPNYIMTDLQCEWRIKKRNTHPGISVAFRELPQCEKSSSDVYIKVNSQNLCGKEVFFRTYESDEVKVELSSGHSLGSLPGFSYTYRSVYPSVFRSCNETFRLSSSAPMKRIVEHLKPEFFSGSLSCWWRITAPSPDSLFRMEIHNLSFGQKRDSIDCTNELELRDAESHKFIYNKCDDSEQNKLVRHSFSQHLLVSLHLGEEFEHDFFMDITFTAVKNTGCEGVTKTLNASQEEKTFEWMFKNSDCTWKIAAPSYEYKSVEVKVVELSLNPNGILQCGTQLLLSNSKYFHYSDSHTLNCDSQNIPYVFTSERQFVYVRVKHIHHSGSDSQGLGFRLEYRALGYESNDSSDSSSIKKIIGGVTGVAMVLLIFTCVCVCIVKRRKAKREQRLQERQNRNITTISTNDNFSTGLAPFTNIVPYSAAATRTYVSREHFQEEQFPEHQQYSGARFQEEQSDEAHPLQPNPYSEAPPSYEEATERDSHNPSVWSSAANSHREIMNEGPPPEYSPYMPGGPLDLQHHQTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT47</accession>
    <name>A0ABM1VT47_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trichohyalin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825589.1">
        <property type="nucleotide sequence ID" value="XM_035969696.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854168"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825589.1"/>
        </source>
    </evidence>
    <sequence length="556" mass="65941" checksum="6CB111136F8BB634" modified="2025-10-08" version="1">MTYLCFKCHKTLTKSIYPLSYPLVSPGLPGDEGPPRRKPHARQVKANARLGQVVDDLLVPEHKAARRLIRRSQRHKPDDKMAAITNNMTLYERIIAYRKLKQRETGGESKQEDGLERSETGWGSVDISQYTYKKEDEEARTPTPPPTLTSHEDRRVDRNRKQKSQDYDEKLTARDVYVDVDENLNKKEPLPPVRSATPVRKRTPSPLGERSASAQELNRHSVLPPIQGGREERREEEIRRERVNEVRSERYSVDDRREGEAVVATSAVVAAASMRKEDRRYEEDDRDRDERRDERRYDERTEDIRETSRKEDRRYDEEDRNRNVRREEKRYEEEENRRERIRRDEKEDLRSRSREEEKERRYEKREEEERYERKERDSRREEYRESRNREREERGGRDRDRYDTLETAAVVAASSSTRRQSPAAREENTPQQRMRRDNTPPRSQPRSEPVTSQRAMPRVEGAVAAAASGNQPRRSPGPRNERRGEEQRKSRARRPSVEEEIDRLDKMVDRELNSIIDKHASKPSNNNDNKSGESQLKEKIFHPSFQADMDRFLRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUR2</accession>
    <name>A0ABM1VUR2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Gelsolin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC100533528</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_013083598.2"/>
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        <property type="nucleotide sequence ID" value="XM_013083599.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035970261.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="gelsolin_S1_like"/>
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        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
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        <property type="entry name" value="Gelsolin-like_dom"/>
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    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
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    </dbReference>
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        <property type="entry name" value="VILLIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
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    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="57"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="178"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="290"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939053.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035826154.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42444" checksum="6ACD965A447B57AA" modified="2025-10-08" version="1">MSGLVKAKKYDWKDSNLALFGSDVEKNVKKESAEQEPAWKNAGSQVGIQIWRIVKFKVQPWPKEDYGKFFEGDSYIILNTYKEQDTDQLLYDVHFWIGRHSTQDEYGTAAYKTVELDTLLDDVPVQHREVQGHESELFKSYFKSITIMKGGAETGFRHVKPEEYKQRLLQITGNKQSVTVTEVPLNKNRVTAKDVFVLDNGLEIFQWNGEECAKEEKYKAVQVVQQIRSERGGKPSVEVFDQNSDDGSTFFDHFNDNEDDDDDDSEYEDNDNKTPELYRLSDSSGEFEFERTKEGRVFKDDFSSKDVFIFDNKKEVFVWIGKSASKSENQNALSYAHKYLQGTQHPLLPITCVKEGKENKFFRSAIAA</sequence>
</entry>
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    <name>A0ABM1VYQ2_APLCA</name>
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            <fullName evidence="6 7">Papilin-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="6 7" type="primary">LOC101862295</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827544.1">
        <property type="nucleotide sequence ID" value="XM_035971651.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035971652.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045023438" evidence="3">
        <location>
            <begin position="29"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="214"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="284"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="422"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035827544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827545.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="57249" checksum="B60DB3BA011E286B" modified="2025-10-08" version="1">MSHADIMRYLVVSACLLTSMLTNGVAKASQPSYCTLPAKTGNCRAAMTRYYYNPSSQSCQSFIYGGCQGNENNFRTESLCRAACVCTQAANRGNRWGWACFSSRPYFYDVDNGQCKRFGYRGCNGNPNRFSNADQCSLACLTSQCFLPREVGLCRAAFGRFFYNTTSQKCESFLYGGCQGNLNRFDTVEECDRKCTTPIQNEANTNQNFEDTICLQEKKIGTCRAAFPRYFYNSKTNRCEFFYYGGCQGNENNFASKSACTSRCMRRRNRGKRATLGRMTREDCQLPPDQGNCRNFEKAFYFNSNTQKCEAFTYGGCLGNKNRFESVESCQAQCMPPGQNIKNSIIGGGLRGFRNAHTPKLASTLFGGSFPPLLSLSDDIRTTLTKPSSPGDGTDGATKNAAKSQEPALNHSQLFPKVRPVCKLPKDRGPCLGLMEAYYYNSGANECQKFMYGGCLGNGNRFPNKLWCELTCKQTMKQNQSSYPSVSSDCQLPPETGLCEGFFSRFFYNSRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZA4</accession>
    <name>A0ABM1VZA4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Xanthine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101846241</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827747.1">
        <property type="nucleotide sequence ID" value="XM_035971854.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="11">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="214"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035827747.1"/>
        </source>
    </evidence>
    <sequence length="1293" mass="139772" checksum="23D5B1E58DB4F344" modified="2025-10-08" version="1">MESITKADVQGSMSLTVNGVVYKVSRDEFPPSTTLLQFLRESGVSTGTKGCCYRGGCGVCVVAIALASPEDDGVKHRSVNACCMLLYACEGAEVTTVEGLGSVSTGLHSIQDRLAQHDGAQCGYCTPGQVMNMYGLLKQNPRPSAKQVEDAFDTTICRCTGYRPILDAMKSFAVDTPGDVLDIEELTAKTCPSSGQACRGQCRVDRGVMTYQNGVDASLSWLSPQSLDDLLSVLAKSAKTNYRLVVGNTGFGVYEELGAWNYQTLVDIRGIKELYIVDVSPASHVTLGANLTIADLIAKLDGDLSDLAYADTFRRHLKLVASNTIRNVGSWAGNIMVKHAYPNFASDVFTLLETVEARLNIVSHKAREQVSLSEFMTSDMVGKVIVSVQLPKYPEQTRQIRSLRTSQRLQACEASVVSGFNFPVKDDGTCLLVAQPIIALQLKGNPLIRCKKSEQFLTGKALSDAAVFKEAVKILSEEVVSGAKVSDNQDFLTSLAVSHFYKFVLSACKTRLPDQLVSGGSDLERDVMSGTQDLGTQNPENFPASSAVMKLTAPSLVTGEIKFLDDLSPYRGQLFAVPVLSTVARAEIASMDASSAQGIPGVVAFLQASDIPGVNNWRPKGWYGPGEVQELLCSGQVLYAGQPLGVVVADNEVTARQASSQVKVTYKNIEPAVTDLKVAIAKQRFHTEPRTFSAGDVKAALASAANVVSGRVHTGDQYHFHLENQVAVCSLEDTGGMKVKASSQFLDFTQGSVAQVLGMTDSDVTVEVTRLGGGFGGKMYYSSQVAGLCALAAHKTKAPTKMTLDLNTNMQMQGSRTAYRFDYEVAFDDCGKLLAVDLTCYSDSGAVFLPIDANEALEWFVDNCYLCPNWSVKAFSCHTDRPPSTACRAPGSAQAIFAMESIIDHVASFLGLEHLAVRKLNLFSEGEKTMKGVVLESCLIRDVVSQMEEEMAYAERQRAVQEFNARHRWKKRGLHLMPSMYSMVCCEMLCLNTTVSICHGDGSVVVTHGGVDMGQGINTKVVQVCALKLGVPVEKIRVSPSSTVSSPNGWFTGASVTSELVCMGVIKCCEELTERIQPIRDCLGDSTEWDALVRQCFFEMVDLTAYYRSGAGNRSVKNYSCYSVCCAEVELDVLTGQYQVLQVDYLCDSGVSLNPRLDLGQLEGGFMLGCGFFLLESMTFEPDSGRALSTGTWTYKPPMAKDLPIKFNAKFLRNSPNPVGVLGSKAVGETPVASGACPLFALKRAVEAARSDVGMTEWFPMDAPATVQRVHAVCSTPLRHMSLCADDTVKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZN2</accession>
    <name>A0ABM1VZN2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium- and chloride-dependent glycine transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118478416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035827875.1">
        <property type="nucleotide sequence ID" value="XM_035971982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478416"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF241">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827875.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19007" checksum="E7ECB883127CC5DE" modified="2025-10-08" version="1">MSVCSPQSGFYWLTLMNHYVPSVCLMLLALTEVVVLAWVYGTKRLCRDLETMLGYPVLPFWAPTWKVITPGFVLVLWLTGLLDFRTIGSIYPGYPFWSDLLGLAISLLPIVPVVIVAARTLVRAKGTPLQRLRESVKPSPLWCSAEVTAPDPIMPEMETLTKQIQDERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZP9</accession>
    <name>A0ABM1VZP9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Solute carrier family 28 member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827892.1">
        <property type="nucleotide sequence ID" value="XM_035971999.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478418"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827892.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="19798" checksum="67FDCE04E2007522" modified="2025-10-08" version="1">MLYHPCVMQVIIGKIAFVMRVTLGTTAAESLCAAGNIFEGQTEAPIMVRPFLALVTRSELHAVMIGRFGTIAGAIPLDCMMGVEWEEAGTVAELLGVETFLNESLAYDKLSSFIDNRIRSEIIATYALCGFANLGSVGIQLGGLCPMVPNRLGDLAQLAVTALLGGIVTNLLTACVAAESTNRNMGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W020</accession>
    <name>A0ABM1W020_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hypoxia up-regulated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101861155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828013.1">
        <property type="nucleotide sequence ID" value="XM_035972120.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861155"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="955"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="755"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="662"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="964"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="979"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1074"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035828013.1"/>
        </source>
    </evidence>
    <sequence length="1090" mass="121398" checksum="1318A90790624AD4" modified="2025-10-08" version="1">MKLSSCRKGLCVLAVVTTLFSFTSARLAVMSVDLGGEFMKIAIVKPGVPMETVLNKESSRKTPTMVAFRDGERHFASQAQTTAIKFPPKAFFYLGQIVGRSYDDPQVELYRKRFPFYNLLKDEERGTVLFKIDDDTSYSPEELLGMILEKAREYAQEFAEQEIKDAVITVPAFYNQAERRAVMAAANMVGLNVLQLMSDNAAVALNYGVFRRKNFNSTMQYYMFYDMGATSTTATIVGYNVVKTKEGTLLESNPQLTVKGVGFDRTLGGLEFTLRLRSHLAKAFNNQKKTKTQVEENNRAMAKLFKEAERVKKVLSANNDHTAQVEGLLEEKDFRSPVTRPELEEMCQDLFERVTKPVEEALKVSEITLPEISEVILMGGGTRTPKVQELLLKFLGRSELGKSINTDEAAALGAVYQAAYLGKGFKVKKFGVREGNIYPINVEFEKQKTEESGEKSKVIKRTLFGRMNPFPQKKVMTFNKHTKDFHFDVLYSSLDFLSEADKGSFSKPVISRYNLKGVEDVLSKNKEQAEAKGIKAHFRMDESGLLTLDKVESVFEKNSSADDSGEKSTWSKLGSAIGGLFGGSSPEDDHKVEDTPDTPEWETVYLSANEDGDTMKPAGEADDKESAGDAGSEGQDKGEQTGAKEEEKKDAKEEQGEGESDGEQKDDKEKPAKEEEAPKEGGEETGEKAEKSGEGEKAGEEGAKESDKKEKSEKKANSSEKGSEGEAKETEEKKPPKVVSIKEEIKAEVEALDLKDISTDQLKAAKKRLSDLRAADKAKVELEKAQNELEAFIFDFQDKLSQGPHEKCTTEEEREKLNKMFSEASDWLYEQPDDAKKSEYTNKLKSLREATKDVSVRVYEMEERPKALEALRSALNQTGLFMATVKNISDEEDPIFTQVELDTLEKLINDTTKWRDENVAEQKKLALHQMPSLITEDIAQKIAALDREMRYLINKAKNFKPKAKPKEEKKKASNETKTENTTTTESPEPSQEEAPPTEEPEAKPDDAAGSDTPAADSQEKAEAPTTPETPTSDDSGERTSSGKRRPKSKRKSSQAESQEEVLELDAAAGDAETSTEKEAKTDKDTDHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0N5</accession>
    <name>A0ABM1W0N5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Muscarinic acetylcholine receptor M3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC118478543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828228.1">
        <property type="nucleotide sequence ID" value="XM_035972335.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478543"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035828228.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="30609" checksum="91E8B2BFDEF4460D" modified="2025-10-08" version="1">MFAHGEGELSRDTMTSFLGNEGHVMTPSNSQDEPDVNEVKGIQESSCNNNFAVEEHAVKENMDDDDDDDDDDGCDGIASGKERKIDDENENENGDDVNGHLNNEDTPPEERPLLSPEAPSTMTDNANNTKLNSSARNSSSSPPPSTLPVKPTFIDVPVCNTQPAESKTKVFKKHTAGKHLQIDAQTNSIKRKRPSTVRDRNLIANIKTAFMLFIVTLVFIIAFLPALLMANSLIPFNMVVFYGYFVYNVANPFIYAFMNQTFREDVKRIIKLCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0Z1</accession>
    <name>A0ABM1W0Z1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478571 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828334.1">
        <property type="nucleotide sequence ID" value="XM_035972441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478571"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828334.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37652" checksum="9BDB0592EDC0E6B7" modified="2025-10-08" version="1">MNTLADEDDHQLDSMARNSLVLMEDRDGHETMRASLVFEEDSTELIKLIQSAASGGRGEEAPDDGLETPGRHSEHSHPHSHHHPHSQDKSYSSPRKMPEKLAKDIDNRIGSPLRNSSSGSPSKFVFKNRDSVDEKRRSKVVALGKPPIHASTKREKSFDGATGLASELGRQAGSTNSLSSNRDRESSLPSSKPKSILKDKNASMSERNSNGDNRFLGEASAPSVEPTSADGRVIVTMKDEPNLGTPREQSPRRPPGPRHAMSKPRESESASGYHIRRFSRQGSSSSASPRGYADARSLAMPEADGGPVPKPPPGHAPKNAVVSARIWISGMHKDKSLGAGGTSWRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W266</accession>
    <name>A0ABM1W266_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Galactose mutarotase</fullName>
            <ecNumber evidence="6">5.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aldose 1-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101850606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="6"/>
    <dbReference type="RefSeq" id="XP_035828759.1">
        <property type="nucleotide sequence ID" value="XM_035972866.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850606"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035828759.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35701" checksum="D256BA5F6EE052C8" modified="2025-10-08" version="1">MGFKWVVTWVCPRARHDNPGKFDDIVVAFSIFLFLFTVDYETKSPYFGAICGRVANVVAGAQFDLEGQTYKLYENRPPLSVHGGKAGFDKKTWQAEVVGDNKLSLTYVSPHLEENYPGELTSSVTYSLDDHSALTLQYAATTTRTTVLNLTNHAYFNLAGHGHGHLNDHRLKVFSDKYLVLDDIYVPTGEIQKVDGSPFDFQSPVKVDVSRLQSIQDGLGYFNTFPLENAGQLKLAARMEHAPTGRYLECRTTEPGVSFYTSGYMPQIAGKAGAQYKQFCAFSLEAQHFPDSIHHPNFPTTVLKSGETYTQTTVYTFGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3K7</accession>
    <name>A0ABM1W3K7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC101848562 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101848562</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112041.1">
        <property type="nucleotide sequence ID" value="XM_005111984.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005112042.1">
        <property type="nucleotide sequence ID" value="XM_005111985.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829250.1">
        <property type="nucleotide sequence ID" value="XM_035973357.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848562"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179:SF1">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045023445" evidence="1">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005112041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829250.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32963" checksum="A3965EBEE4A9E8E9" modified="2025-10-08" version="1">MKLCLAIAAMLVCLLTSQSHAQDTPFPHQGDPDDPHGGVPMGVSNSFCDNAEDSISIDWDPESTEEYTCPEGQRRGLGDAEINTQTCEDEAKKPIHKCYPEEIDYSDDPLPTSGPHRPLWPKYGEYRYVPPQRWLHSLEHGAIVFLYHPCADKGEVDLFRTVSNQCLRRHILSPYKEMPEGVNFVLLSWKCKLLLSNADMEEMVRFVRDHALRAPEGHVYNDGQYSKALLHPAKMVSNIMDTQLCPHFFKMRPVYERIKADAVNRMQTGSLIDQQVMESVERLLQRLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4S2</accession>
    <name>A0ABM1W4S2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uridine-cytidine kinase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118479148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829665.1">
        <property type="nucleotide sequence ID" value="XM_035973772.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118479148"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829665.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11387" checksum="209A6EB168E06E84" modified="2025-10-08" version="1">MHTFPFSLSVLDWQVLNHEQHERAGQNEYNFDHPDAFDFDLMVSTIRRLKDGKSINVPIYNFATHAREKEMKTIYGANVVIFEGIMAFANLELLEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I6N858</accession>
    <name>I6N858_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Potassium channel subfamily T member 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Slack isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101855059</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2010-10" db="EMBL/GenBank/DDBJ databases">
            <title>The regulation of sodium-activated potassium channels by the fragile X mental retardation protein in peptidergic neurons of Aplysia.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Brown M.R."/>
                <person name="Hyland C."/>
                <person name="Chen Y."/>
                <person name="Kronengold J."/>
                <person name="Fleming M.R."/>
                <person name="Kohn A.B."/>
                <person name="Moroz L.L."/>
                <person name="Kaczmarek L.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HQ413690">
        <property type="protein sequence ID" value="AEP32442.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001297418.1">
        <property type="nucleotide sequence ID" value="NM_001310489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I6N858"/>
    <dbReference type="SMR" id="I6N858"/>
    <dbReference type="GeneID" id="101855059"/>
    <dbReference type="OrthoDB" id="257992at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005228">
        <property type="term" value="F:intracellular sodium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000011">
        <property type="entry name" value="Potassium channel subfamily T member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000034">
        <property type="entry name" value="Potassium channel subfamily T member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="10 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="14">
        <location>
            <begin position="337"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1118"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1129"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1156"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEP32442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="NP_001297418.1"/>
        </source>
    </evidence>
    <sequence length="1177" mass="132886" checksum="CB96FF1648A399D7" modified="2012-10-03" version="1">MASLETDVIVTDVYGLNSDSDSDSCDNVCNIDTYVDGSAPVKYFTHELSCRGRLRRFFIRNASTRIASTFFDLALKSLICIMYVVRVYLDNPSEYECDGHPCRSAGNTTQSERQELYSRSDINWYVLLWVHRSLPIWITELCLAFVSLIKAMLLVYIATKGHRMEQILTKNFFLEIICAVPMLATLAYPPVLKDLFVPVFFNCWLAKRALEKIYNDLHLTRQRFQTISVTSLQQMVLVLANIACLVFVCICCIQHIQRGSEETPLSMFQAFYFVIVTFSTVGYGDISPDIWLSRLFMVLMICVAFASIPRQIEGLVSTYMERRKAGGEYSHRSATRNKHVIVCSSSLTQDTLMDFLNEFYAHPKLEEHTVILLCSQELDSSKQVILKDPKWSHRVIYMKGSSLKDIDLKRCRVHQADACFFLAPRPSPDKAKADRHTILRSWAVKDFAPNCKQYIQLFSVANKIHVKFAEHVVCEDEFKYALLANNCLCPGISTFVTLLLHTSRGREGQTSSEEWQRLYGKCSGNEIYHIRLGDSNFFGDYEGKSFTYASFHAHRKYGVSLVGVQRDLPGSTIQLNPGPRHIMRKADICFYMNITKEENSAFILAHPNRDPSAVERARLPQGTEKASRVASMIASVGTVALELQHTRVSTFSSDTNLITRTGSRSRNLSLPKGLNIQSLQKRPSIAPVPATLEANNIHINITGSDTEDEEEEPCDMEPDDFVEYVRGFPPVTPYVGTSPTLCHLMREKRPMCCLQLSTECTHCPHRNAREYNWSNPAIIVAADYASSGLYNFIVPLRSHVRPKKSLSPIVLLLTKPPDSGFLALISYFPLVFWMRGSIDCIEDLLKAGIHITDNVVVVNKETSNAKDEDTLADCNTIVSVQTIFRLFPKANIITEISAAPNMRFMQFRPDDLYALSISKQEKKERERGSNIYYMFRLPFAAGNVFSASMLDALLYQAFVKDYLITFVRLLLGIDMAVGSGHLGCVKVGKDDLWIRTYGRLYQKLCSQACEIPIGIYRTQPHVGTESVSPPKSRWGKQPSSGMSLAAHVEDTGDGGKFTPERQEIIQMVKCRMQSQGLPLDDYHKNEVSDRRSTISYVIINPSYDLKLEPGDIVYVIRPSSLSPQPSPLTDERKLLGQEKRQEPPGADTDRYKDVAVSDEENDESCDDNLVSKASQGP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-04-01" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>P15513</accession>
    <accession>Q07974</accession>
    <accession>Q27916</accession>
    <name>MYOM1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName>Myomodulin neuropeptides 1</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName>Myomodulin-A</fullName>
                <shortName>MM-A</shortName>
            </recommendedName>
            <alternativeName>
                <fullName>Neuron B16 peptide</fullName>
            </alternativeName>
            <alternativeName>
                <fullName>PMSMLRL-amide</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName>Myomodulin-B</fullName>
                <shortName>MM-B</shortName>
                <shortName>MMb</shortName>
            </recommendedName>
            <alternativeName>
                <fullName>GSYRMMRL-amide</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName>Myomodulin-D</fullName>
                <shortName>MM-D</shortName>
                <shortName>MMd</shortName>
            </recommendedName>
            <alternativeName>
                <fullName>GLSMLRL-amide</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName>Myomodulin-F</fullName>
                <shortName>MM-F</shortName>
                <shortName>MMf</shortName>
            </recommendedName>
            <alternativeName>
                <fullName>SLNMLRL-amide</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName>Myomodulin-G</fullName>
                <shortName>MM-G</shortName>
                <shortName>MMg</shortName>
            </recommendedName>
            <alternativeName>
                <fullName>TLSMLRL-amide</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName>Myomodulin-H</fullName>
                <shortName>MM-H</shortName>
                <shortName>MMh</shortName>
            </recommendedName>
            <alternativeName>
                <fullName>GLHMLRL-amide</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName>Myomodulin-I</fullName>
                <shortName>MM-I</shortName>
                <shortName>MMi</shortName>
            </recommendedName>
            <alternativeName>
                <fullName>SLSMLRL-amide</fullName>
            </alternativeName>
        </component>
    </protein>
    <gene>
        <name type="primary">MYOMOD1</name>
    </gene>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="DNA Cell Biol." volume="12" first="53" last="61">
            <title>Molecular cloning of myomodulin cDNA, a neuropeptide precursor gene expressed in neuron L10 of Aplysia californica.</title>
            <authorList>
                <person name="Lopez V."/>
                <person name="Wickham L."/>
                <person name="Desgroseillers L."/>
            </authorList>
            <dbReference type="PubMed" id="8422272"/>
            <dbReference type="DOI" id="10.1089/dna.1993.12.53"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>VARIANT LEU-362</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <tissue>Abdominal ganglion</tissue>
            <tissue>Cerebral ganglion</tissue>
            <tissue>CNS</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="J. Neurosci." volume="13" first="3358" last="3367">
            <title>The myomodulin-related neuropeptides: characterization of a gene encoding a family of peptide cotransmitters in Aplysia.</title>
            <authorList>
                <person name="Miller M.W."/>
                <person name="Beushausen S."/>
                <person name="Vitek A."/>
                <person name="Stamm S."/>
                <person name="Kupfermann I."/>
                <person name="Brosius J."/>
                <person name="Weiss K.R."/>
            </authorList>
            <dbReference type="PubMed" id="8340812"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <tissue>Buccal ganglion</tissue>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1991" name="Peptides" volume="12" first="683" last="690">
            <title>Structure, bioactivity, and cellular localization of myomodulin B: a novel Aplysia peptide.</title>
            <authorList>
                <person name="Cropper E.C."/>
                <person name="Vilim F.S."/>
                <person name="Alevizos A."/>
                <person name="Tenenbaum R."/>
                <person name="Kolks M.A.G."/>
                <person name="Rosen S."/>
                <person name="Kupfermann I."/>
                <person name="Weiss K.R."/>
            </authorList>
            <dbReference type="PubMed" id="1788132"/>
            <dbReference type="DOI" id="10.1016/0196-9781(91)90120-E"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 53-60</scope>
        <scope>AMIDATION AT LEU-60</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <tissue>Buccal muscle</tissue>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1995" name="J. Neurophysiol." volume="74" first="54" last="72">
            <title>Nine members of the myomodulin family of peptide cotransmitters at the B16-ARC neuromuscular junction of Aplysia.</title>
            <authorList>
                <person name="Brezina V."/>
                <person name="Bank B."/>
                <person name="Cropper E.C."/>
                <person name="Rosen S."/>
                <person name="Vilim F.S."/>
                <person name="Kupfermann I."/>
                <person name="Weiss K.R."/>
            </authorList>
            <dbReference type="PubMed" id="7472354"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 63-69; 193-199; 203-209; 240-246 AND 358-364</scope>
        <scope>AMIDATION AT LEU-69; LEU-199; LEU-209; LEU-246 AND LEU-364</scope>
        <scope>FUNCTION</scope>
        <source>
            <tissue>Buccal muscle</tissue>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1987" name="Proc. Natl. Acad. Sci. U.S.A." volume="84" first="5483" last="5486">
            <title>Myomodulin: a bioactive neuropeptide present in an identified cholinergic buccal motor neuron of Aplysia.</title>
            <authorList>
                <person name="Cropper E.C."/>
                <person name="Tenenbaum R."/>
                <person name="Kolks M.A.G."/>
                <person name="Kupfermann I."/>
                <person name="Weiss K.R."/>
            </authorList>
            <dbReference type="PubMed" id="3474664"/>
            <dbReference type="DOI" id="10.1073/pnas.84.15.5483"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF MYOMODULIN A</scope>
        <scope>AMIDATION AT LEU-256; LEU-266; LEU-276; LEU-286; LEU-296; LEU-306; LEU-316; LEU-326; LEU-336 AND LEU-346</scope>
        <scope>FUNCTION</scope>
        <source>
            <tissue>Buccal muscle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Exogenous application of myomodulins potentiates ARC muscle contraction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text evidence="3 6 7">Expressed in all ganglia of the CNS, but only in a subset of neurons including L10 in the abdominal ganglion and B16 in the buccal ganglion.</text>
    </comment>
    <dbReference type="EMBL" id="L01421">
        <property type="protein sequence ID" value="AAA27758.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="S55210">
        <property type="protein sequence ID" value="AAB25131.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="S55211">
        <property type="protein sequence ID" value="AAB25132.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="S64300">
        <property type="protein sequence ID" value="AAB27697.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="A28340">
        <property type="entry name" value="A28340"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191423.1">
        <property type="nucleotide sequence ID" value="NM_001204494.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P15513"/>
    <dbReference type="EnsemblMetazoa" id="NM_001204494.2">
        <property type="protein sequence ID" value="NP_001191423.1"/>
        <property type="gene ID" value="GeneID_100533334"/>
    </dbReference>
    <dbReference type="GeneID" id="100533334"/>
    <dbReference type="CTD" id="100533334"/>
    <dbReference type="OrthoDB" id="6085322at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051041">
        <property type="entry name" value="FMRFamide-related_np"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986">
        <property type="entry name" value="FMRFAMIDE-RELATED PEPTIDES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986:SF22">
        <property type="entry name" value="FMRFAMIDE-RELATED PEPTIDES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0027">Amidation</keyword>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0527">Neuropeptide</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000001837" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001838" description="Myomodulin-B" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001839" description="Myomodulin-H" evidence="5">
        <location>
            <begin position="63"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000001840" evidence="1">
        <location>
            <begin position="73"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001841" description="Myomodulin-I" evidence="5">
        <location>
            <begin position="193"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001842" description="Myomodulin-D" evidence="5">
        <location>
            <begin position="203"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000001843" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001844" description="Myomodulin-G" evidence="5">
        <location>
            <begin position="240"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001845" description="Myomodulin-A" evidence="4">
        <location>
            <begin position="250"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001846" description="Myomodulin-A" evidence="4">
        <location>
            <begin position="260"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001847" description="Myomodulin-A" evidence="4">
        <location>
            <begin position="270"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001848" description="Myomodulin-A" evidence="4">
        <location>
            <begin position="280"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001849" description="Myomodulin-A" evidence="4">
        <location>
            <begin position="290"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001850" description="Myomodulin-A" evidence="4">
        <location>
            <begin position="300"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001851" description="Myomodulin-A" evidence="4">
        <location>
            <begin position="310"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001852" description="Myomodulin-A" evidence="4">
        <location>
            <begin position="320"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001853" description="Myomodulin-A" evidence="4">
        <location>
            <begin position="330"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001854" description="Myomodulin-A" evidence="4">
        <location>
            <begin position="340"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000001855" evidence="1">
        <location>
            <begin position="350"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001856" description="Myomodulin-F" evidence="5">
        <location>
            <begin position="358"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000001857" evidence="1">
        <location>
            <begin position="368"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="5">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="4">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="4">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="4">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="4">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="4">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="4">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="4">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="4">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="4">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="modified residue" description="Leucine amide" evidence="5">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="sequence variant" evidence="7">
        <original>S</original>
        <variation>L</variation>
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AAB27697." evidence="8" ref="2">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="1788132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="3474664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="7472354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="8340812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="8422272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <sequence length="370" mass="42254" checksum="3A792085939C88CB" modified="2001-09-26" version="2" precursor="true">MQVYMLLPLAVFASLTYQGACEETAAAQTSSDASTSSASSEHAENELSRAKRGSYRMMRLGRGLHMLRLGKRGGPVEPESEENLETLLNLLQGYYSDVPEYPSEFDDTDLAYPYEEYDAPAHPRYRRSTPPTDGVVAPDVLQKGSSEFEDFGDSQLDESDEGYYGYDPENYLYGDFEDYLEPEEGGLGEEKRSLSMLRLGKRGLSMLRLGKREGEEGDEMDKKQDESLNDDFENDDIKRTLSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRDDDEKEKKSLNMSRLGKRSTQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>P35589</accession>
    <name>SYB_APLCA</name>
    <protein>
        <recommendedName>
            <fullName>Synaptobrevin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Vesicle-associated membrane protein</fullName>
            <shortName>VAMP</shortName>
        </alternativeName>
    </protein>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Proc. Natl. Acad. Sci. U.S.A." volume="91" first="4688" last="4692">
            <title>Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F.</title>
            <authorList>
                <person name="Yamasaki S."/>
                <person name="Hu Y."/>
                <person name="Binz T."/>
                <person name="Kalkuhl A."/>
                <person name="Kurazono H."/>
                <person name="Tamura T."/>
                <person name="Jahn R."/>
                <person name="Kandel E."/>
                <person name="Niemann H."/>
            </authorList>
            <dbReference type="PubMed" id="8197120"/>
            <dbReference type="DOI" id="10.1073/pnas.91.11.4688"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>PROTEIN SEQUENCE OF 50-59</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>PROTEOLYTIC CLEAVAGE (MICROBIAL INFECTION) BY C.BOTULINUM NEUROTOXIN TYPES D AND F AND BY C.TETANI TETANUS TOXIN</scope>
        <scope>TOPOLOGY</scope>
        <source>
            <tissue>Ganglion</tissue>
        </source>
    </reference>
    <comment type="function">
        <text>Intrinsic membrane protein of small synaptic vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">Secretory vesicle</location>
            <location evidence="6">Synaptic vesicle membrane</location>
            <topology evidence="6">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location>Synapse</location>
            <location>Synaptosome</location>
        </subcellularLocation>
        <text evidence="4">Neuronal synaptic vesicles. In vitro integrates into vesicles co- and post-translationally (PubMed:8197120).</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 49-Lys-|-Ile-50 bond and probably inhibits neurotransmitter release (PubMed:8197120).</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 48-Gln-|-Lys-49 bond and probably inhibits neurotransmitter release (PubMed:8197120).</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">(Microbial infection) Targeted and hydrolyzed by C.tetani toxin (tetX) which hydrolyzes the 66-Gln-|-Phe-67 bond and probably inhibits neurotransmitter release (PubMed:8197120).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">It is not known if C.botulinum or C.tetani infect this organism.</text>
    </comment>
    <dbReference type="EMBL" id="U00997">
        <property type="protein sequence ID" value="AAA19442.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191557.1">
        <property type="nucleotide sequence ID" value="NM_001204628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P35589"/>
    <dbReference type="SMR" id="P35589"/>
    <dbReference type="EnsemblMetazoa" id="NM_001204628.1">
        <property type="protein sequence ID" value="NP_001191557.1"/>
        <property type="gene ID" value="LOC100533331"/>
    </dbReference>
    <dbReference type="GeneID" id="100533331"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0770">Synapse</keyword>
    <keyword id="KW-0771">Synaptosome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000206740" description="Synaptobrevin">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Anchor for type IV membrane protein" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vesicular" evidence="6">
        <location>
            <begin position="105"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="v-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="site" description="(Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)" evidence="4">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="site" description="(Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)" evidence="4">
        <location>
            <begin position="49"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="site" description="(Microbial infection) Cleavage; by C.tetani toxin (tetX)" evidence="4">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="8197120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="8197120"/>
        </source>
    </evidence>
    <sequence length="180" mass="19746" checksum="ADC7780DA74CF347" modified="1994-06-01" version="1">MSAGPGGPQGGMQPPREQSKRLQQTQAQVDEVVDIMRVNVEKVLDRDQKISQLDDRAEALQAGASQFEASAGKLKRKYWWKNCKMMLILGAIIGVIVIIIIVWVVTSQDSGGDDSGSKTPATAGTSPKPVESGVQGGGGRQQRPHSQLVERRNVLRRTEDHIGCRPHIHSFIHIFMICLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA66</accession>
    <name>A0ABM0JA66_APLCA</name>
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        <submittedName>
            <fullName evidence="9">Somatostatin receptor type 1-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">LOC101860616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005088984.1">
        <property type="nucleotide sequence ID" value="XM_005088927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860616"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="450"/>
        </location>
    </feature>
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        <location>
            <begin position="294"/>
            <end position="360"/>
        </location>
    </feature>
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        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_005088984.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="52167" checksum="8592F6991EE035F6" modified="2025-10-08" version="1">MSLDGRPTVDIMPAPLDIPAPPPGGGAPPPRGPPPITADMDILIDKSVYDVVEAVFNCGLINLVCMLGALGNVLNIYVLSKHGLQSSINIVLFSLAVADLLLLLTLPLRKISLIIAYFDEAYALTFEAYVICYQFLTLNRIWALISHTHVVIIAVERFLAVYFPFKVGQLVSPVKMKIITVCTHVSWYVLLTPMFTMFKLIWVRHPDLNATVAIPGISDFYFEHELAFNFYISFIVNLLTGGLQLIFVLSCSVAVAIKISKMGRKRQAMISSAPGVLSSIALGHTTSVRTLSSVVESQQGSFPKSDPSTNDKERDRVTAGQGDNADEEARDLTHKQPQEQPLGQTLEQSKGKPHVGSRSTSYLWGAKDEKSVSSSGHTRASTRVDLKVVRMLLVVCLVYLCFVFPTFFLYVFQYVFQEMKSPYWHRVNFVATSVHMLLLALNSATNFIVYVATSQKFYTTLKAIFVKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAN1</accession>
    <name>A0ABM0JAN1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein LOC101851456</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101851456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_013079833.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851456"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
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        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
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        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
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        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005089295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012935287.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="50705" checksum="6F06D39BA7678445" modified="2025-10-08" version="1">MSSSAEDGLMNLLEAMLALAAREARRPKPPPVKPGGYPEDQFVDLSEEEKEEFSCSICYQILKETMQCVNHHKFCHSCLLVWSTTGQYANRIRCPVCRTHGYYFRNNEVDDRIGVKKVKCHMDSCKWSGQCKYLLSHRHTTYGDAGTNRPGSSASSVASIPRLSQVPPHVPPAVGARFVGTGLTTRDSADSLRGGDSATPRGTLANRGRLLASSSPQSSTSQETVIELPPPSGSGAPRGNNPAPRRVPPVRASSNNRIVFNHSGSHRDGNNNVGGAGSVAVRPSGPPNVSESSESVSSSITGGFTPRPPSAPRTSSNVVNTRRLPRITNPPPPRGLPLRRHQPPEAVSLGASASSSSPQRPSAPAENLGEIRDRLQESRNRLDNLMSSFSGELDRSRQEMADFQQERERQRREQLEEVRELGQRLGQVASELRRLLEHRRHLPVFSDDDDDDDDDEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBP5</accession>
    <name>A0ABM0JBP5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089972.1">
        <property type="nucleotide sequence ID" value="XM_005089915.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855839"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19136">
        <property type="entry name" value="AKR_DrGR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005089972.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32881" checksum="FFF5D80A416CEF7E" modified="2025-10-08" version="1">MKRSIELVSAWTMPYVGLGTFKTRGYDLLYTTLDAALAAGYRSFDTASVYRNETDIGKALKELLPKYNLTRKDIFITSKLGPADQGDGKASSAFSRSLSNLDCEYLDLYLIHWPGTHKLQPGDEQHKKFRRESWKAVEEAHRQGKLRSLGVSNYLQHHLEELLEYCTVKPSVLQIEYHPHLVQKSLKKFCDDHSIHLQAYSSLGTSASENKLISDPVVVDIAMKCEKSPAQILLRWAVQQDIGVLPKSTNPAHIVENMDIFSFSLSTEQLQALSNLDQQMHYCWDPVHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC30</accession>
    <name>A0ABM0JC30_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC101853661 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101853661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090223.1">
        <property type="nucleotide sequence ID" value="XM_005090166.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012940159.1">
        <property type="nucleotide sequence ID" value="XM_013084705.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853661"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052435">
        <property type="entry name" value="YY1-Transcr_Regul"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088:SF3">
        <property type="entry name" value="GON-4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088">
        <property type="entry name" value="YY1 ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="967"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1189"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1311"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1372"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1454"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1526"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1655"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2085"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2311"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2374"/>
            <end position="2449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2570"/>
            <end position="2640"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <begin position="45"/>
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    </feature>
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        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
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            <begin position="145"/>
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        </location>
    </feature>
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            <begin position="173"/>
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        </location>
    </feature>
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            <begin position="191"/>
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        </location>
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        </location>
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            <begin position="354"/>
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        </location>
    </feature>
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        <location>
            <begin position="373"/>
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        </location>
    </feature>
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        <location>
            <begin position="533"/>
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        </location>
    </feature>
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            <begin position="583"/>
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        </location>
    </feature>
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        <location>
            <begin position="678"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1072"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1190"/>
            <end position="1213"/>
        </location>
    </feature>
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        <location>
            <begin position="1240"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
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        <location>
            <begin position="1414"/>
            <end position="1425"/>
        </location>
    </feature>
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        <location>
            <begin position="1426"/>
            <end position="1435"/>
        </location>
    </feature>
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        <location>
            <begin position="1465"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1545"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="2090"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2122"/>
            <end position="2144"/>
        </location>
    </feature>
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        <location>
            <begin position="2325"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2584"/>
            <end position="2604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005090223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012940159.1"/>
        </source>
    </evidence>
    <sequence length="2714" mass="297093" checksum="FD57B3B1C024D908" modified="2025-10-08" version="1">MSDNCKKPQDSPSGEECDSSLIMANSSQTDIEDSNKDDDRGNGNDDGDKEDGDNDEDETDMSKEENSSVFSSPLDQKQILDDARRETRTPKKKEATNEIIDSTEDPLETPSKVLMRTLEAFSKIEESAKASASSKTPSKTLQKLTGKKAVQRTPHKALQVTPVKKSKGGAKKRSSEVHLELKEKQSKETADSEWETDNDEESEDGDENIGSIDARLEEKASNMNMNAKNVKSIIHHILTNEHVKDMFSDLLQEEKDGSSEEKDSVTPKKFSPEKLDILPILTRAKVKDLVDKGSVPSPSKHTKAGPSILDVEFTEEEDDEEYDPNKDAEARDSDDDESVVSSRFSEIGSPYPLTPSSSAIPQSSEKMPDTPGSVASSVSASPAVVSSSKNLESAFNACEQASTSYVSETGDTIARRTRSKLPLTSTCITDIESAFVAPDITADMYDNTCKDEDWMQFLSSLYKPTDDTIQDDDANDPEFNYIAEAEKEEEDVEDFLFDKPSKITKKELNILISELEELFEEDQLPYRVVGNAMPSTSNEPQSTNTERSSNTEPSRNREPSSSTGHLHCNNERRSSNNEQPYSNNGQVCNNNNQQYNRNEQQYINNEQQYNCYKQQFHNNEQLYSNNGQQYTSNGQQYSNNNQQCGGYSQPYSNTRQPFSNQTPVAPTFTEFKTPLAPPSQSSRMHTVTGQRSSQVSDVSQTSSIHERSQDFSQQSHDAGITDEQHAIIEDHMRKHIQLLTQSFLLSQTHCVYRDLKGQPENFLRELDHFRKSSAAGTASVFNVCNLDPALEVLQEVGGMGLEPKKKSSGIYEAHIGMCKPLRQVVFNSAAFVYPQLLPSLRLFAKSKGNKYRNVMPSEDNLIALGLLEFRNCQDANTVDLIAELLLRGKDGKQVQHRIYRMCHCKQEQNVIKYVKQKGRLPPSFPKPRVDEFYACPPRDQLPHLLPPWLRRMQDGLRYKLFKEQDKVLKKRERQQQLEDSDSSDGQMRRPRKKPRKSRLFKKRKKHNHFSDSDDDPDQTKAPNKVKVLKKQGKQQEPLHSNSADGQRIADQKSKSKKILQAMEKYKPIAPQTVPQSSDEALSQTANQTPQGAQLTPAVTTSHPHSTSVGQPLFGAGTPPITGIYIQFGTQPSSVPVLPPQIVSNLSSSISNLTTSSSSRQRPAVSLQSNALVGVSPIATVSVAAAQKTLTKQVTSQSVSTKTSSKSSKGRGSSVLPQKVPPQSPDVLSHTLKSCGIIQSPGVNSPGQNVDSPLVDRPTLTSTPVSVGSSHPRRKHSSVRNLHNEFDNAACTVADDASLSEEMDDTLCDSVKEKGDANSQNSDDIEEESESGLYTDPTLYDEEEGTGLRGKGFLQDVGNVELNETFIVPASKSNILPGMPLKGLHPKGSPQEMSSPKSLPMEDLQTESLPFKHLQSQSSEQMESSQTLPSSKSARPSANDDIEMIPQSLSISKKAADGTHEEGMQNVGSMNESEESSSFTHVDEKMDVQTDGPVTLLRSKPKSLSPPQSNSLLGHKELEMASKLCSAGGSLGSDTEGKKVVGPGATSPSRETHISSGPQHALNKPSTPKKTPRRCRRRIEAQLKTPPKLQTIAPKALSPNQANAPAYVPLPKISPKRKALNQQVRHILPKSFTFEVKSPSPTKAAAMVLSKKAKLHQQQKSPAKILPMPEPAPTVNIKDLTPSKVVTRSQRGRPRSITIGCQKTPPAKNKCKTKATAQSSRDLKEVEETVSGNAPKPVSGEAEKTGTSSSQDQLDAEGALNSDTEDVHLDDLMAACTTIGYDPKKLVTADSDTKTKAQKRKDAFMAIFEPDIVDSDPKKDERDTAYAQHYFNRVKSALEEDQEHFLKFLTLLRDVNKDHTNPVELYVDMVSLLSDHQDLVDDFAGFLLSFQAVVCGCLVPSLEYTQIREILRKLEMYCDSSASCSFQRTLKMLLRWLSMTQGEQPDMALKERLMAIFKHVPGLMDYLMSYFLHEPIPDCSKEEFEDVDLEAKMELGDAVDEFEEINLCSGREDYNTKQCTCSCHQDALDSKLRRKITHCFSCSLQMSDGLPVLKRSRFSFEALKVIYPLEEKEKLARAKREAAKLALAKARSQKPGKKKGRPGSKRTRKKSVGSDVKLEPVVASSNANSQNPVLSSSSHPVQESTVSQAVQSPIVNVVPVSVSNKAEITSRALEATKVQREAPKETTKEAQAIQDNSSGTLKIVINTSAWKSGPSSHHTNYGLPSVPSPTISTVPSSVSSLAEPSVRLPSVPLTVTASSTPPQAPGTPVQLPFPVRPYMSPGLTPGMTSTPVATGLRLPVFFTVKPQKFLAEEQKGSPEPTVPAKKVPKLKVKKSQSKAGKSKSSKQFVAFENIDSQNISVSIQSRPEDRIATDASQELHVSDCPSSPLTEPPPVSPVLDRLNPGGETTAQVEAGPCSEPHTSFLQPEPVAVSSKGDHADSMSMASSSKKDDSLFKAPCEVLDLASGDSILQISPSKLRGKIPGSLIRSHLEHFSLGGFEESLDMQQIQQLAQAISPGKGHGESMSRFDLMAFLESSNLTLASNLTLKDSLFPGGSGTTESSSAGRVSFAGALSQHKTSREGTDASGQAGSCGTEGQISASSSHANEGAQVALQNKTDGPPEDHTAGSAVLGEDTSSSYTAPPSVATLDNLNWTEAWDIAILNVVTEEGVTPSAIDRLHREIPQKSLDEIATRAELLIQWVQNNADTDTESEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCW5</accession>
    <name>A0ABM0JCW5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline-rich receptor-like protein kinase PERK2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090803.1">
        <property type="nucleotide sequence ID" value="XM_005090746.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845519"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047237241" evidence="2">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090803.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="21721" checksum="820C230734A554DA" modified="2025-10-08" version="1">MLTFSCVFVALLALFGGVFGRSAPITTLPPTSILPCIFDRPTCYPGTVLVESNNGPCPEFECVRVSSPSPSPSSPSPSPSSPSPSPSSPSPTPFKTCPPVMMPACRFGDYVKQEYDYQDCEYWTCTSNPSSPVTTLPPTPNLPCLFDRPTCYPGTVLVESNYGPCPEFQCVPVSSPSPSPTTPLMCPVFTMPDCSTGYFTVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE72</accession>
    <name>A0ABM0JE72_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101858161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091667.1">
        <property type="nucleotide sequence ID" value="XM_005091610.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858161"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005091667.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21510" checksum="CA5D7B207E4F582D" modified="2025-10-08" version="1">MAEKGPLPEGRLDHSAPETLSLKERMMSLSLSNASAREWFSKTRESVRPWAEFVNTKRFGVPKSIAPVPKRIVKNIETFQGNYLFVFMGLVVFCILTSPLLLVALAACFGACYLISVKNQDKKITVMGKELSLAQQYAAVGAMSFPLFWLAGAGSAVFWVIGASFFAIMLHAGFYQTQEELEGFDLQLEEVQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF96</accession>
    <name>A0ABM0JF96_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein RF_0381</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101856953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092360.1">
        <property type="nucleotide sequence ID" value="XM_005092303.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856953"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="377"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005092360.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48602" checksum="9AEB4077118404EA" modified="2025-10-08" version="1">MLLRTQMAGLEFYDAVLNNDLQQLKRLVAQHKLDLNGKFLEVRRKNDAGLCPIHLASYRGHTYMLQYLIDAKCDVNHTTGTLRRTALHFAVQSHKMACMLLLISAGAKLDAKDTFGNSPCHYAADDGYCQILDVLIRRGVNVNSQDITSKTPLMKAVRNNKTDAVLRLLRATADLNITDRNCDMALHYAARNGCVDISDILLSAGSLINVQNYWGRSPLMEAVCYNHKEVVQLLLTASCDVNRREFKTGDTALHIAIKRNYTRVVELLLAAGSRHDVYNHQGETAIHDAVAGNKMDIMWLLLAYNIDLDVPVKYFPNGIYKSVFKLAAERGHYKLCRLLATIGHVDYSARMYFYAGYVQARPGEQDDALVWLRTALKRVVPLQQLCRKVIRRHAGHKLWEKVESLPVPRALKDYVLIKDMLEHKKESNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHV7</accession>
    <name>A0ABM0JHV7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ventricular zone-expressed PH domain-containing protein homolog 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101855473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MELT/VEPH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094007.1">
        <property type="nucleotide sequence ID" value="XM_005093950.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855473"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039888">
        <property type="entry name" value="Melted-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630:SF10">
        <property type="entry name" value="VENTRICULAR ZONE-EXPRESSED PH DOMAIN-CONTAINING PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630">
        <property type="entry name" value="VEPH-A/MELTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="683"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="862"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005094007.1"/>
        </source>
    </evidence>
    <sequence length="885" mass="96772" checksum="490CF9FFF69A0295" modified="2025-10-08" version="1">METAHEGKKMNKLFAEVLAKKDLSKAGELFSLSDDLIEKDLEKIVEEIIVIADSDEYEKSDNDQSVVEICITRITTAIRETENICKHAEPLVRLLSVCHKHNLSQVAKDEDPPHAKIASDIMSRLFTYYSNKHVMTLTIPAVVQFLDCDNKDLVRSVASYLSLATIDNADLLAHHMTLVLSTVLKGNYLLGQVLPQIYDQNPGPVLERVEELAELLERCDTTEKVCFVQLFSKVAKTHPKLLEPYVPQLCSYLPSSLLSSMVLMILVDLALAQPASVGGQVAQVQAVVGTQPMLMYQVALITGAVGTLSQEEGRKSMEYLVSRLSGMDQSILPSVLQEIRGLGQAHPALLAEYVDQISRLSTSGSSAVRLMVQQIREDVRKNSNSPSSPSVVQEESPPRHKSPSPFARSEEEEAAGVSTEQAPAKQTRSVSSQTEGTVTIITVGNPPNATHPSGTVSVKSTALAPSGGSSQQSLVKLSHLSSDQAYGGAQEVTSHTTIGTSTDLSPQGQTVRDGVQLFCEKHFAKIKNFISKLNATIPLPAKCSVVNGKHKRYLKLHFECGHQSDQCLYSGSHFTLNTRLPKLWLHLMFLSVQAQSRFALSQRDSNVSSLKTCWDALKGETTSNFLTLVTSSFPTQKDQLGLLQELHQMRYFDVFELNAAVAHWACFLCNHPEKLSELLNDGYPEIAGQLKEKKGKWKFFKRWKTRYFTLSGGSITYDKSNATKASLPVTKIQSVKAIRKGIRDIPKAFEIFTEDQTYMFKAKGHHNVEQWVQCLHIAVARSQIGGSTSSSLMGGASPFTVEEGEGDSHHAGGKSCLVGRPEGAANNGAGVWGTKVKHSRGASFSAGGGVSSSRMVAHPGLFEPQHSHHGLGGKDTRKIVTDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIJ2</accession>
    <name>A0ABM0JIJ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101852911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094442.1">
        <property type="nucleotide sequence ID" value="XM_005094385.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852911"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094442.1"/>
        </source>
    </evidence>
    <sequence length="800" mass="89831" checksum="76492CEEF7349215" modified="2025-10-08" version="1">MIIQVDAKARVNLATNLASMQEAGELCDFAVIVGESKILAHKCILAASCEYFRTSFRFSQSSEASSSIDLSHLGCSMSVVKNIIQSFYKNEIELEESSVEAVLRLVDYFMCEDLRLCVEVFMDKTLGFHSAVLYFQLALQYRLNSTSLFRNAQCYLWFRFHDYFLYHPDTLDSSVDVLRAFQQYRLFHFCSPLQVLDFMLRNLSHALSTVQHYDAEEASKECCIERITQTFEIISSVFDNMERAAIKKWTPYLLRFVRKWMMKGKMLKAFGSLKNHVHDLKEKLVTEALGESESSRSVEESKIGEVLEIQSEEMSENSSNGNAENTNLDLSGPRVLSRPSLGSANCDAPDNSNGLLCSAANFSASSTASETVTTQMTPACRLWKVNGRDALRSNGFECAPELRNPESSVPFVADALSVVTSPTPDSATALTSPMSPKDVLERHMSEILVVLAPSAEMSSQVNVVDAGKSWPLVSSPQLELALYDVELKTWRCSGRLEFPLPGAMLEKHMWRLAFFNNCVYLFSLVKATGIEYDLTTKKWTFLKCSELFAPHNEDSPVKSVIPIAVGSKLIVLSMSRSPRTDGSYWTQQNFHEFNFQTKTFTHSAMVRDERIDLPVTQWTVHGNTLITVKASTMMYRHLSRIQYIHVFDADTSSVKTHNVVCAMESGIKVLMKGSVVYLLDKEGWCRSYDLGSSEWTGLTRYPTQTQTSFTSPYTQESVYPALTRVTCHAGSSRWEVTTSPSNCSAYMQEVLVADDGSIATEHHAPPPFQFVTGLCPGMMARSMLDQLSQAQFEYCESKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM39</accession>
    <name>A0ABM0JM39_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable serine incorporator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096899.1">
        <property type="nucleotide sequence ID" value="XM_005096842.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846574"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005096899.1"/>
        </source>
    </evidence>
    <sequence length="695" mass="77212" checksum="E3CA5B45A947CA5D" modified="2025-10-08" version="1">MGCCTSQLACCCGPASCALCCGFLPPINESTGTRVMYTGLLTFTFILQCLMLVPQLREFVQDNFDEMSDLCVKFEPGGHCTRLTGYKAVYRLGLAVVTFYFLLMVLTIFVPSSDHWRASVQNGYWLFKFFVLCGLCVAAFYVPPAFSVYWMYVGMVGGFLFILLQLLMLVDFSHAWNASWVGRTKGRRNLCGLFATIVVAILLFALAAGGMVLLFVFYGLKDCDTNRVFLGINTGLCVLLTFITILPCTETRNANASLLQASVICLYVVYLTWSALTSEPPEQFESLLDTLNRKTMAYFGADPDDGSSVERVLDSSKIPDKAFEDSYNYTAQCRPDPSFPQSDLIAAYAGLLIMFIMAVYASVRTSHDAHKLGIRTEGKSCFCCIITKRDNPSLLGGQKVVQNEADGVVYSYSFFHFLFCLAALYIMMQLTNWYRPLETDLNRFGLNWASVWVKMASSWACVIIYIWTLFLPRCCPGRNLSFPYAARDEEGNDEADGDGSIDSVPVEFELSNEASRRSSRQRSYSEQSVRSGGQASVQELPRSSRENLAKRAIKGSVENLSGARGSRENLAKLAMKGSRENLRNSKAASRENLRNSKMSSKENLRTPSREQLKPLTGSREQLDSPMDKSGPSSGVKHQLKKKKMAGSKENVNLMKDRMNASREKLSTSQSSLSRDPDNEPGAQAKSPPKARSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMM9</accession>
    <name>A0ABM0JMM9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Chitinase-like protein PB1E7.04c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8 9 10" type="primary">LOC101851800</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097259.1">
        <property type="nucleotide sequence ID" value="XM_005097202.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005097260.1">
        <property type="nucleotide sequence ID" value="XM_005097203.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005097261.1">
        <property type="nucleotide sequence ID" value="XM_005097204.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937315.1">
        <property type="nucleotide sequence ID" value="XM_013081861.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825368.1">
        <property type="nucleotide sequence ID" value="XM_035969475.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825369.1">
        <property type="nucleotide sequence ID" value="XM_035969476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851800"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021095" evidence="3">
        <location>
            <begin position="37"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005097259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005097260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005097261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012937315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035825369.1"/>
        </source>
    </evidence>
    <sequence length="716" mass="76410" checksum="C8F84F6B7D5C11C1" modified="2025-10-08" version="1">MRVSPRDSSPKPYPSSPYLIGCWSIMVACVLGTAAAHSTPDTCGDYFFLPVLPNCDLYLEAVPCFNNTHTIVVTMATTAGEVVHSFSVTFGSMKELSLLAVNKKKSEGLVLRSTDDISVYVHKTAGDSMVVFPIDSFEREYQVLSVPAYSRPGTDASRTTSSSSSSSSSSSKSEGGLHNGGRHHIAIQSSLLYIFSPFNNTRITLTPLDEVFGTSSSPSSILQSSFSQTATNSSSSSLSPSLPSWQGASSSSSSSPSSTSSASSSSSVLSSTLLSSSSSSSSPSSPSSSSTVLLDAFEIHVHRIDPTRGYLLHSTDVFAVLQVQTSTKMTKRASLCVDSSLQLLDFVQPIAVRGRHFYLAFPNLTDFSIYISGKENTSVDVTTDTSSLEIKVGSQGHKATDVTRTSSAWLSSTQSVIVYVTVAICSNGSLTASDSGSGSATSQQTCAYNGFYLPSVEHYFTCHGNKTRDGCSCACPSVFQRDVSPDSFGSLRNSTISNSPPSLYPLLVGELFDVSTSISRAPGFKYADDVIVTTNNSFMVFRHDVENLNYLPAGTRLVDIYQYCEPDSYTSLFRDCHAYFNSKGSSSEPGFKDADAFQPDSLQPFQSGPGTVDACSCEFVVDATSSISQSNGASENTDLSVAGEAVANVRMNSGGGGGDIMWEEDDEDTTRPMIAVVVSLSVAIFAVIALISVYMLMEMASRRKHVRNTKIRPFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNI5</accession>
    <name>A0ABM0JNI5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein YxiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097850.2">
        <property type="nucleotide sequence ID" value="XM_005097793.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846650"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005097850.2"/>
        </source>
    </evidence>
    <sequence length="166" mass="18323" checksum="7E20A50BE1A281A0" modified="2025-10-08" version="1">MAASHARHCIIAVDGSEHSEYAFEWYCKFIYKDDDEVTLLNIPEVNPTVHSKSPNVALVAPEIMVAMARQEHDKINAEMQKFADKLKQHKIGGKVKTIVASKPGEGIIKAAEETHADLIVLGSRGKGTVRRTLMGSVSDYVVHHAHVPVIVCKHPHKHVHPEDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNP7</accession>
    <name>A0ABM0JNP7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RalBP1-associated Eps domain-containing protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097962.1">
        <property type="nucleotide sequence ID" value="XM_005097905.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853235"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF174">
        <property type="entry name" value="GH06923P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="351"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="513"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005097962.1"/>
        </source>
    </evidence>
    <sequence length="792" mass="84487" checksum="E4C93B9F35531D7A" modified="2025-10-08" version="1">MEGLKLGDRELQYYAELFQACDVEGSGKITGPKASELFLASGLSPDILKQITELCGAKRLGHFGRSQFYIALRLVAIGQAGLPLKLDTLNPGKDIPLPKFSSAKGNEQAALADRKKSSGEPDGVVTADKPSGQLSGQLPPPPGSKKSHSRSLSGQYRGVVPDGPPAQFNSTTQSNTRDESPHNSKSPPFSPTQSPPTSPANQKPLLKQHTAPAMMFPNSTASGGGAPTQAPPLSSSSMDNMDSTAPPDRGHVNPVAMGDGAAVGRGQAGPAATAPGGQGHNHGHQRPLSGEQQPGQENGSWTMFEDEDSQMLIGSGLKQHYNSLEPPNFDSSSISSEAESVDDVWSITEEQRDYYVNQFKTMQPDLNAVITGPVAKHFFEKSKLPVVELSKIWQLSDLNCDGALSLEEFCIAMHLVVLRRNDIELPEHLPISLMPYSALASDEPFAADLPPGSTLKRATPPSPQNVAQWTAFVQESDSSSGVPSPAHLANFEFAKPSADPELKIVQPVAVRMSPEGLPMQNEGVDRGRAFSDSAVPHEPGGADPGELTPPLTKQRANTESHPLDSSQSETPNSKYSTPIQGRPRPVPPKKQSAVPVVVRGQLQPPPGTPADAVSSNSEQNASGHSSQAPPTPPPRPPHGRSMSVDVKSNAQMVAPAVPPRVSPKEVSQAQSAPKSGDVSAPVSEGTVVVQPLDAPSGPENSQPAPVSAEKDLMEDEDTADNSGKDRLQPKPAMALRQVSRDRRDILMAVRTHKERNTMLTRLNSELNQELQEVMEQRIALEIQLEHLRPFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPL4</accession>
    <name>A0ABM0JPL4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101857798</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101857798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098569.1">
        <property type="nucleotide sequence ID" value="XM_005098512.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857798"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005098569.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48389" checksum="1F7C27D3A6443260" modified="2025-10-08" version="1">MSLAVAMASTEQTPDFHMLHLQAAVEHNSDVLETILRTLQDVQYLSVKTDKRVGALETQVKELLSRNSQVPLDQVKGCDLPASAAQATTLTSPEVIGEIMDGLRGESTEVKSLIREEAGRLGDICSQHHSDVVSKLEKAEELILPPRSEMAAEIVKMTSHFEGVENGMRTIENSTNEYLYLLNNVHRNLIPKEELTNTLKTLTEASEKQLCQLNKIVKEHDSVVSSGNLSHMKGAGMQVCSRLHELRDEFGTRWKTASRDDSPDSDREVAECHGIQGVVETSEKNHEYRYRFGVKDFSRWRWGESQYSDVWHIGEDPSHVKGVVKFSFNNEKIAVGLRYSRCLCPQVVGSGLRGKTQVAVTVTALCQVGKGWDWKLGSKEGEISGEFVDWEEWLVSGDIPISELKRRGLVNNDQLVLQYQICLPGMVGKVIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ99</accession>
    <name>A0ABM0JQ99_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uridylate-specific endoribonuclease</fullName>
            <ecNumber evidence="11">4.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101859707</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ribonucleotidyl-uridine-RNA = a 5'-end dephospho-uridine-RNA + a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA</text>
            <dbReference type="Rhea" id="RHEA:67792"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17354"/>
            <dbReference type="Rhea" id="RHEA-COMP:17356"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173117"/>
            <dbReference type="ChEBI" id="CHEBI:173224"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ENDOU family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005099015.1">
        <property type="nucleotide sequence ID" value="XM_005098958.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859707"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21159">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039787">
        <property type="entry name" value="ENDOU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037227">
        <property type="entry name" value="EndoU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018998">
        <property type="entry name" value="EndoU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439">
        <property type="entry name" value="PLACENTAL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439:SF11">
        <property type="entry name" value="URIDYLATE-SPECIFIC ENDORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09412">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142877">
        <property type="entry name" value="EndoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51959">
        <property type="entry name" value="ENDOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="EndoU" evidence="12">
        <location>
            <begin position="7"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005099015.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33968" checksum="3961B3DE60DA824E" modified="2025-10-08" version="1">MAEGFAADSELSDIISKLWDMDDNKCYPGTDYELYLQGYVNNPREVGRDYARHNLFDWLDEEQVFSRPTYKAFRALLDNYEMDLSEEEEVTWEERQENYDFLTAIMDTAVMKEAHQFLVSKEVAPEDEEEFKKMLHDIWFRLFKRKGGRGNNSCSFEHVFVGEGRGDDMIGLHNWIQFYLQEKAGNIDYHGFFRRETVRDDEILRLMAVQFTWKGIMGKPMCSVFVGSSPEFEIAAYTISLLLDRDGKMDVQLGEYEVELVVHSFGWKKKLGTAYLAAARMDQYAKKKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQC3</accession>
    <name>A0ABM0JQC3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 3'-phospho 5'-phosphosulfate transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849376</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099054.1">
        <property type="nucleotide sequence ID" value="XM_005098997.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849376"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF13">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047512839" description="Adenosine 3'-phospho 5'-phosphosulfate transporter 1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005099054.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="50520" checksum="7E1A77D5AF7B23D5" modified="2025-10-08" version="1">MELFVAALLLSLPAVLMAQETTDVETKAQIEWSDFWMMRLFFNLIGYATIFVPGFLIIRHLRKIKYNETAGNSTNGNSTKGPGCIQNFMVLCVFGKEQHVSLEEGGSKSSSSDSQDESFTKRTIRLLICVAGLQGSYLTWGILQERIMTLEYGSTATSSGEFFKNSQFLVFINRILAFIMALLVIFFRKQPAHTAPLYKYSFSSFSNIMSSWCQYEALKFVSFPTQVLAKASKVIPVMLMGKVVSRKTYEYHEYVTAVMISVGVSLFLLTSGDATRHKDSVTTYSGLVMLVGYMLFDSFTSNWQGALFTQYKMSSIQMMAGVNMFSCLLTSVSLIEQGGFFESSAFMFRHPEFMVDAIILSICSASGQLFIFYTIAQYGPVVFVIIMTVRQGFAILLSCVIYGHPVTVIGFFGVLIVFAALFLRIYANQRQRALKRAAAAAIPLSSVETSEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQP3</accession>
    <name>A0ABM0JQP3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease H1</fullName>
            <shortName evidence="9">RNase H1</shortName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101863901</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005099284.1">
        <property type="nucleotide sequence ID" value="XM_005099227.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863901"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="11">
        <location>
            <begin position="187"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005099284.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38467" checksum="A7E920FC8826EAFC" modified="2025-10-08" version="1">MQRFLHAVLSRSIRSTCVMPKETSWYYAVKRGRKPGVYHSWPECHEQVKGFSNPVFKKFSSSEDALEFVHNSKGFTPCTSSGPPVTVGQLRPAISTTMTRQDSSSSQDQDLQEIKRTLQIVQGKLESVVSELAQLSSTVNQIESVVFHAPGSKRAFHTSASSNMGQQQKRPKFDTSEENFTGKPFPDADATHVYTDGGCFHNGQNGAKAGIGVFWKTGDPDNISERLTGRPTNNRAEIHAAIRAVQSAKKKGIENLILHTDSQFLINGITKWIKGWKKNGWALTTGKPVINREDFEELDEELKGINVKWMYVKGHSGHPGNEAVDALAKKGVRKPLPDADSQQDTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQY5</accession>
    <name>A0ABM0JQY5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rotatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099466.1">
        <property type="nucleotide sequence ID" value="XM_005099409.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845471"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030791">
        <property type="entry name" value="Rotatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029249">
        <property type="entry name" value="Rotatin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691:SF1">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14726">
        <property type="entry name" value="RTTN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rotatin N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1605"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099466.1"/>
        </source>
    </evidence>
    <sequence length="2303" mass="251143" checksum="AFAF3C5923E4D7C9" modified="2025-10-08" version="1">MAGNLRRDVDFSGIFRKLGHSLEEIRVRALENILSKLEHQLICDADIVHEKHLYIRLLEWFNFTDCPKKADVFSLLNRLAQHSAGAQLIQDIGGVEFLSQLRQDIEACHRPVIDQILESAMRLPDSREEGHAAECIYQKPSESAVWGASMTSTNDGSRSHLSHPSEAHSAHPAQASIERLGRHNHAGPGYFASTVTAAPLHTKLSAGPETMAPSQDLFMPKFANEGNNCNLFRLSTFPWLPLTHTDQQVIASTNSSLQTKDPNMLIGACEFLADVVFQDFPAELFLQRPEILKNLLSLVSLTAPAEHPVVIQACHTLSAYVHGLQVRIRYFQDPVLYTSKQELNSSSPSLVSSTSSSTSHLAPPPGQGHAGVGLGDRRHRGDGQDGDSSVSASRESSLGLEPSDSNADNDLDLDDGPRLQSQQLTLPQFCVAVLQRALPRLRTAHENLGVSVLELLHGTLTILSSVLDAEVWSDLREPAREVVDRLTDCLDQMCELLGFHHHSNHAVSPINAELGDLSTHRVLYTGLVTTMTRFLLMVPLEKMGSILPEKLKSTLHTVVYDEALAMSQPRCRAVSLAVANSLGLSVPVDYQRVLDVCSSLAKTCVFCLQCETESLKSEELAELAEASVLSLNYHLHLPFVTKFVAFTSKIYSKKKSRPEVLCQCRGVLLQLMAYPNDSVRQACYAAVLAEIKKSLQVNSCKDPKSKAYLGSKFMMNADVLYELSTFGLADTDAKVRTSATDCLHHLLQSQLLMSEGLWQEFMLALTKSLPILQSYTDQSTALGRLLWSMLDPTTSSHNVPLLDKLRGSLRLLYLSDKTLRAQASKHVRWFLSNEQDTEGKMPATGDLEPTKIDSCLILSTPVLIDDDPTRSVFTEEGMKQVFDIFTADPVDPGVKKSAGEQLAIMLKDPHLHALFKSHGGVEIACSVIQQSVVSTAEEADSKQKPDTVAVLPACLSMLHSLARYDYTLRHTLSRDSELYHCLVRVSLLHQSQEQIKSDVSHILTLLLFDEVAKFDIGSGQANVPGTRFSLPAQVIKRYRLPFKPACHHISSPNAASLPDPDTDVMALSGPREMMRAAWNVAWQGGLHQLLDSFSTRLFSDTASEFSSSLALSPIDRTVLKTSSVSWMLQAKVKAIEEASSHGQVVAALDRMSSYVTGVRIPVVSEFFCSADWYSALEKFLQVTPSSASDQSLLLQILRFISAVLRCVSPRLSASGPSTLPSPLSWLVEKLYQPNSPLVSLMARPFSAASSSSPEGGESGSHVKRSLDKELLHYITSINNHFPYQLCQRARPGQVRGDLVRKLQHRLNITDAPHFYNLASLEGTLACLMHVTARPGWCKQCSELDATSLCSQLLNSLLEVVWSFHIGRGGTSRSFMGKGVTKSTALCLRHLAHEMINNSEDQEWVKNWLYTRRDSVAGSDQGLDWLLTLWAYRDAEVRAAGVGIAVALTSCEAGRLLVAANSKHVPGGVWAAAFSILLDPSECSMVCQQAALLLVNLTSQSMPSGDLETGPGTWQGPLVTDTDYQVMLVGVDALIALLSHTNFYSVAADLLTSLYTPSVIQPILVTTELPLVLESTANSSLSSSDASSLDRTGATALTSVSSLSTHPTPNITARSKTLSTDRSKASGLAALQENSLSSSSNMETPRGSQGDVPQERVHARPATTVQTTVPEGQNIATPGVLCAVVKLMTNLVNLTPQRSLSDMKSHSLITSLLNAVDPGLVQVLCEEMTAGQMGSACALNLMDFLRMYGAVADLLTSCVVLDTNTRMELLRHSSGLTSLASLLLLQWREKDDLGEVCLNVSVSVLDLLTSLLQTAGQPALTTLTSVVGQIWAPLTESLGCMLEENSSSRATQHAACLNFLGLLCCEEAKSLVKNPDRICESASLSELLDAPLCVEEAGTESGNPEEKTAGRLLCKVLVGLFDTVTSSAGEEKRRAGGQRSGVRLRVVSTLKSLLAVSQSAKVTALEAGLVESTIEHVKQTHAQLSLETLGMVKSGGKKEEPFLQEIIIMFDFLRNFMCGNADVKVACFHSGLTTIAQRLWSWCQEDPALMSSALSLLMAYTAHCDSAASSLTTTMSAQTTGKTSGQGSLLHYILRLAQRELDRDECSPTLRQAFTLLTNLVLSAECRNVLWKNSFLNQFSNLNPRRKRGKVRVVVETLWCELLLALSFSVDGQQIILKIPDVLTVLLDMMEVGSTRCQHCATLIVRNLCCHAPNKPKLLAADKLVSMLVQQIEKKEEGSTQLVASSALWALVYNNHKARVQVKSASVAPRLAESLHDLQASGSMSQVTVSSCENLKAIINAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQZ9</accession>
    <name>A0ABM0JQZ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal acetylcholine receptor subunit alpha-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005099489.3">
        <property type="nucleotide sequence ID" value="XM_005099432.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850806"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="127"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005099489.3"/>
        </source>
    </evidence>
    <sequence length="377" mass="42597" checksum="5FEC6F753C624B68" modified="2025-10-08" version="1">MVYITNSADENQVMLQHPPLLRVLHSGSVESHNTEFIKTSCRFDLSLFPFDTQHCDVMMVVMGGDVVIRPHVHFMLEHEPLYNFLSMPGEWSIEHKTVESKDTPGPVRFLALTLTLKRASLYYNLFLIAPLVVTSLVTPLVFWMPPGCGEKMSYLVALFLSNTVFFNFVGSILPRNVSEVPRLACFLSGTSVSCVVAMAATTLVLHRYQEEVDQLNVSSETGSNSLENKTVRPADGTTSTIKVLPVYKQEIDQLNVSFKGSNSVETVSLGSADCFVSTCSAEKRKQMKKEQDGLKCGEKEPKILEEAELETEDERRFRRRKNNTIVPEGKCLSRSKMVHYYACNDSWRLSAWALDKISFAIFCLINLSFYLWVFLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRX2</accession>
    <name>A0ABM0JRX2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine-specific histone demethylase</fullName>
            <ecNumber evidence="3">1.14.99.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101845699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:60244"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.99.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.66" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005100139.1">
        <property type="nucleotide sequence ID" value="XM_005100082.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845699"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017366">
        <property type="entry name" value="Hist_Lys-spec_deMease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038051">
        <property type="entry name" value="Histone_Lys-demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="6">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="388"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005100139.1"/>
        </source>
    </evidence>
    <sequence length="800" mass="89021" checksum="F6E7C74EDEB65282" modified="2025-10-08" version="1">MASSSTKVTTLLPKKDDSGHSEHGKRPLPADDDDQEGNSGSDVGRRSKRKRAKVEYKEMDEHLAHISEDEFYSEEEKKEKENTKAKDGKEPKEKEGKEQKEKDAKQSSKDEEAIAEESDHSADDPSGLEGAAFQSRLPVDKMTTQEAASFPDIVQGPPQSQKVFLHLRNRILQLWLENPKQQLTFEAALQEIEPPYNSDGQLVLRVHSFLERYSFINFGIFKRLKPLPAKKNCKVIIVGAGIAGLGAARQLMSFGVDVVLIEARDRVGGRIQTFRRGNYVADLGAMVVTGLGGNPVTVLSKQINMELHKIKQKCPLYESNGCTVLKEKDEMVEREFNRLLETTSYLSHQVNFNEINCKPASLGQALEAVIKLQEKHVKDKQCEHQRNIIEMQEKLRKCQAQMLTLKDKVQELHKQWREASDVKPPRDITAEFLVKSKLRDLNAAVKEYEQSTAKQKEIEDKLHELEANPPSDVYLSSRDRQIMDWHFANLEFANSTPLSNLSLKHWDQDDDFEFSGSHLTVRNGYSCVPIALSEGLDYKLNTVVKQIKVTEKGAEVVTTAKNGSNQQVLKADAVLCTLPLGVLKECVNNTPNVPQFIPPLPDWKADAIGRLGFGNLNKVVLCFDRVFWDPSANLFGHVGSTTASRGELFLFWNLYKAPVLLALIAGEAAAIMENVSDDVIVGRCLVVMKGIFGVNAVPQPKETLVSRWRADPYARGSYSYVAAGSSGNDYDLLASPIAHQAGAPSRLFFAGEHTIRNYPATVHGALLSGFREAGRIADKFLGAPYCAPQQTKPPAASEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSM9</accession>
    <name>A0ABM0JSM9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="7">PARP</shortName>
            <ecNumber evidence="7">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100533538</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_005100577.1">
        <property type="nucleotide sequence ID" value="XM_005100520.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100533538"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08002">
        <property type="entry name" value="WGR_PARP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF66">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WGR" evidence="11">
        <location>
            <begin position="66"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="9">
        <location>
            <begin position="321"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005100577.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="60269" checksum="C2F8822C354456E5" modified="2025-10-08" version="1">MPPKRKAAGKAAATKAKKAKQAAEEVKVEEEAAPETMKDKIAKLKAADKGKPKKHKPDTFCHLSSSSEVHEDFDAMLNQTNIGHNNNKYYVIQVLNCGKSYYAWNRWGRVGETGQNALKGPFSSPEPAIKDFEKKFRDKTGNAWSARDNFTPKPKKYTLLEMAGEEDDGEDVVDMGPSDSGVPKKVLPSKLNKETQALMKLIFDNDMFRDALKKFDIDVKKMPLGKLSKTQIAKGFEALEEIEEAINSNKPKNSLNALSSKFYTAIPHDFGRRVPPAISTAEEVQKKYDMLAVLGDIEMAQSIQKDKEKAEKESKEDTVPHPLDTNYGLLNCTLDHVDKSSKQYKLLEKYFLATEGSSWRKMKLKEIWEVDRASEGPRFAANNKIDYRKLLWHGTNVAVVTAILKTGLRIMPHSGGRVGRGIYFASENNKSAGYVSSAQGKGIMFLNEVALGSQHRITRDDSSLVQAPSGYDSVLACGQQEPDEKSEVTIKLDGKNVVVPQGKPQKVSKYSSSSFWQSEYLVYREDQCRIRYLLLFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSZ1</accession>
    <name>A0ABM0JSZ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100788.1">
        <property type="nucleotide sequence ID" value="XM_005100731.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857257"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22885">
        <property type="entry name" value="ANKRD27_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22886">
        <property type="entry name" value="ANKRD27_zf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF2">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="250"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="537"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="570"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="608"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="809"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="842"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="875"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="908"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100788.1"/>
        </source>
    </evidence>
    <sequence length="1225" mass="135958" checksum="BBFAE8FE18CF18C6" modified="2025-10-08" version="1">MAASSKYDEDLYENPYFIGIMSKFPAYIDKIVSSKGILCVPKYSIAAQIDLQVTDLEDHILLPTKEVVDDADDFITISGKTVRIGDGSLIGQAGFDSQREASILFAETFHTDEGGSYRVFCIGGFLNRTVDVSPRNSSVNKVLSPTSYQQCMDLLWSHSGGQKSRDSLNRMLSTFATSYDRLEGENLRSIVDAANTHFTKAMQLMLKDSVVRRSARHNVQYMENLKVAVETYVMNAIHKHLFRVITATFATQDAEINKITRNLVSLQLTDLGIRKVFNQNIPPAKKELSRLNRYSTPMGRLFCVKRVVAALTKPPKQNGKEDSKDTAEMMTTDDLLPILIFLIIKSETPNWMANLVYMRHFHFAKSSDDDEFGFYLASIEAALEHIRSGNVRDEIKPLKRERWNSIVVTDVADSSASSSNTVSSATGTPSRQVSQTSVIDEFFKYVESGDEKMVQQMLEKPHRSSEELHLKLCHPLCACDKCDKLMGKLRNDSELVTAYTRDNRGYTALHMAAYYGQGLLIDLLIQNNAVVDATDYLGQTPLHLACQRGYQNVMLLLLHFGADVMARDNEGNSPLHLCCANGHEDCVKALVFYDASLRKMQINTANEFGDTPLHLAAKWGYESIVKALLENGADATLCNRKRQTPVSLAQNVKVQRWLQMAADGQDLQPIRPMYVSPKTRSRSSSSSSTSTFSHHQSSLNIYEPENSASIFRVETASLEAANESEKRRKKEKLFKAIIEGDIQLVKFYLGVQSKVADPDDDDETDVVLPGSSSISDMCHPLCQCGKCRGIVKVTQRSKDKLSVNAKTSTGYSPIHMAVLHSHSDIVALLIALRADLSAHNHKSLTPLHLSCCMKNSLITDMLLRGGAKLDAQDMNGDTPLLIASSNGFINGVKMLIQNKARLNVTNGRGNSAVHEAVKRNQLEVVKLLLEAGAEPRISNKHEQLPVHLTQDPAMQALLMATTFKLNEAEAKAQRQRPVITQDRNENRVCQITIKELFAAFEESDLRTLKALNESVRRFDRTSSLRRAETKDKSSPHLKDIAQAYSIKSFNRGTLRKVQSLDKADPLYIYSLSQSRSMDSQLSSRILNDSLEKCETQDDSLLRVEGGDGSINPQTPTGFRVLPENATTPSGFYSSFEGSMYDEQLTPLGDNLHLSRFEEDFLSSDSGSEQGIAEAPNPNQEPKGTEEQMSDICLSDPSEVEVSPPQAEGDLPSLASAMATAQLSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTN7</accession>
    <name>A0ABM0JTN7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101846971</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005101247.1">
        <property type="nucleotide sequence ID" value="XM_005101190.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846971"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="322"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005101247.1"/>
        </source>
    </evidence>
    <sequence length="601" mass="67328" checksum="BF392DECDDF871B2" modified="2025-10-08" version="1">MRLLPSLCRQVMKYVLVTGGVISGVGKGIIASSIGTILKSHGVRVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDVTLHRDNNITTGKIYQQVIDKERKGDYLGKTVQVVPHITNAIQDWVTKVAETPVEGNERADVCIIELGGTVGDIEGMPFIEAFRQFQFRVKKENICCVHVSLIPQPKTTGEQKSKPTQSSVRELRGLGLSPDVIVCRSVTPLAENVKDKISLFCHVDPEQVYCVHDVTSIYRVPLLLQGQGADDFLIKRLQLQTSQVSRSKHLIARWRELADRHDRLLKEVSIVLVGKYTELSDSYASVIKALQHASLAANHRLDLKCIEAADLEESTRQENPQKYHEAWKELVAANGLIVPGGFGVRGSEGKIRACHWARTKKIPFLGVCLGLQCAVIEFSRNVLKWEDANSTEMNPDTSHPVVIEMPEHNTGQMGGTMRLGKRKTLFKTEKSIMRKLYRNQDSVEERHRHRYEVNPEMVAVLEEKGMRFVGRSEDGERMEIMEMEDHPFYVGVQFHPEYISRPLQPSPPYLGLLLASCKKLSSFASQGFRPSPRMSFCEDSDGGTDGDSLLDEKDDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVC6</accession>
    <name>A0ABM0JVC6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isatin hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102403.1">
        <property type="nucleotide sequence ID" value="XM_005102346.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855806"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045394355" evidence="2">
        <location>
            <begin position="29"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005102403.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33242" checksum="2F4E93A290E7B35B" modified="2025-10-08" version="1">MESVSQILSKLQVFCVIVVAILTPEADGKIYDLSHVHSSDLFYFPGSLPYNRTHVIARDIKPGMYVNAAVITSGEHVGTHMDAPAHFVRGGDPLEKVSVERTIADGVHINCRAEAAAHRDYMVPMQKILDWEKENGRIPDGAAVLFNFGWSLRFNNITDYAGSDQLDDQFTFVQPAVTAEVGQWLLRERKMKIIGVDTFSPDPSLLNGTAVTEMPNHHNILGAGSLIVENMKIPADLPARGFRFHATPVMFEGSGGTQVRAFAMTYDPKSCPDAASVLSPQHPLIMLAAYCCLSTLFLRLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVN6</accession>
    <name>A0ABM0JVN6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RUN domain-containing protein 3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101863449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUNDC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102615.1">
        <property type="nucleotide sequence ID" value="XM_005102558.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863449"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047340">
        <property type="entry name" value="RUNDC3A_B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46251">
        <property type="entry name" value="RUN DOMAIN-CONTAINING 3 PROTEIN RUNDC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46251:SF3">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="5">
        <location>
            <begin position="36"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005102615.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="69383" checksum="6E99762B6AB4F0C7" modified="2025-10-08" version="1">MLTRRQIDVQRENLASMCRISVKSLLDYACLYTHVDDDSEEFINFCSVFEQMVVHRLRPYQRKVWLRGSGPPRHFWEVLVENHNSRRGSLFQTCIPNIEAIETLKSPKAKLRAFIRVALMEKRLSDYIYWLLENPRLIRESYMEGALLASEEASVLCGDLIGLNAIDFNFCLKGNENELLGPLEISYAPFLKYKQTSASRSSDEIEMLRLSGEPSGEVVQTLTEGNLNDLLRLQSLEKDFRGIKEQKDYLEELVRLRDRQLAEANLRLENMRIAQHGREQDVEKEYKLMNVCMLELQEELSKLRQQNNSLKLEVAGLRQYKERLEMKEVPLMDMAGPENMQMEHLPERLTAPPPPSMMLQPYSKKEASPVPSDRRSILSSASDHLHLREDSQSMVPLTGSLSDVNAAIVEATTKPIVTSADSSSRVPAPIEEDVPVAEERTDGNSAVDPNLSQIVMEESKEVLQAKSSIPESNMEGPSQESNVGTDGNTDPSVQNQTGRTGEEETVSPGLNESYVLTGESDAEEKDKSTTVPLVCVTEAQEEDSPTDSPVSIGDPSSAPSPEFGDGDGQVMVLSDGAGSSDKEEDVSNSDPEVLERGNTSSDGSDAAWEMLSDSEQKSEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY14</accession>
    <name>A0ABM0JY14_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Sex peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101859657</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005104219.1">
        <property type="nucleotide sequence ID" value="XM_005104162.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104220.1">
        <property type="nucleotide sequence ID" value="XM_005104163.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859657"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005104219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005104220.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43281" checksum="EBF75B9AC9D47FC4" modified="2025-10-08" version="1">MAYTVNTNFTTPIINLATTSGVPTTVFPDNVTGVSTEVPISNLRSFHETYGSIHGIAAPIICILGIIANCLNIVVLTCKNMISPTNVLLTWLAISDGLTMTAYLPYVILNYHIYTKDVPCPLANARFIMFFAIFSVVVHSISIWLTVSLAVFRYVFIRYPRRGAKLCNIYRAKLTVFIVCVVVTVVTIPNSVSYSFHTTLTEKNETSWYIDVRQDTPGYQFLKNFNLWIQAILVKLLPCFLLAVLSILLIKQMKDAERRRKKLMNKSNAKADDDSRRHRKTNRTTRMLVVVVVLFVITETPQGILQLLGGIIDDFFTNVYGPLGDLMDTLALFNNGINFVLYCTMSKHFRDTFIKIFLSDIVKATRAQSDGQLMTARTTRVSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZU9</accession>
    <name>A0ABM0JZU9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101858657</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105421.1">
        <property type="nucleotide sequence ID" value="XM_005105364.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858657"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045824486" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005105421.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14145" checksum="6BB9B4DCAD99CAE2" modified="2025-10-08" version="1">MDTVLKMVALACVVAWASADTVGKTCTDQSDCAAGQCCQILSEFMVVSRRQLAKAPKTGTCQWYKKEGVSCNVFDQMNGYCSCAPGLECSSYKDPNYHAAITVPPLIGVLTPRKMMPGYISTCEKKTTISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0J5</accession>
    <name>A0ABM0K0J5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-lysine N-methyltransferase SMYD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SET and MYND domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101851666</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105913.1">
        <property type="nucleotide sequence ID" value="XM_005105856.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851666"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF7">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="235"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="280"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005105913.1"/>
        </source>
    </evidence>
    <sequence length="699" mass="79006" checksum="3EE720CE1F852125" modified="2025-10-08" version="1">MNPASTAQVLSELTKQLRGTQRYDEFVANFNKCQTDTERVACLHTLPETSDLFPVQEGYKSKNERDAELLRAEGNKLFKAKDYPSAFYKYTQSILKAPSDSANLALAYGNRSTTNFYMKRYRMCLVDIEMAFRHNYPRTTCYKLYQRLGRCMYYLQRKEEAIKAFQQTIIVLGYAPDISEKNKQEMIQDMTNAIEKCSEITSQNNDVLSENFNVCHQGIPELSADPSKEVPSVSDSVEIRLDSYGGRGLFAKRQIEIGEVLIVETPFSSALLKEFNLSHCHYCCNRVFLPLPCHQCSGVVFCSLQCRDTAWAKFHWAECKILENIQDLKGDLGLLASRMILTAKYEDLITLEESAAECAIERCAGFNAEGVYSSSDYCSAHSLVNHSDKRSFKDLLQRTISAVFFVRYLEFVGYFTSEKRLACKGSQDTASGDSIKLASESELSSKQDIVVPSDKEKLLKEMHQVGGHILRNIMMLPCNAHEVSEFSLNPASPAMSCTAELAAAIYPVLSLVNHSCDPSVVRHSFGNVCVARAIRSIRAGEELKDNYGALYPTMELEKRQKDLSSQYFFRCSCEACVDDWPQYFDIPSERPVFRCLACCDGQVPIPLNNLTESAACLRCGNSQDITQVLLQMGEMESMYKDALTAVIDGDNSRSNVQTLLTYLRFVEHQVKRPWRDINDSQEAIKQCLNMQANCFPMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1V3</accession>
    <name>A0ABM0K1V3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor E2F6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106760.1">
        <property type="nucleotide sequence ID" value="XM_005106703.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849954"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14660">
        <property type="entry name" value="E2F_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF107">
        <property type="entry name" value="E2E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005106760.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="51085" checksum="DC2025FE7DE0BBF5" modified="2025-10-08" version="1">MPRKQTLVARRDLPIFVKQEPSDIVSSSKQLLNLPSIYPRQPSQTSTTTKTADFSGYVNTDIKSEVGEITPHNQSFSGFQLVEDLEKPQVKRRLELDNEITVEGFKTPKPCKRRKSLADSPRARGMRSPLEKTRYDTSLGLLTKKFVGLLRSAPDGVVDLNKASEVLEVQKRRIYDITNVLEGINLIQKKSKNNIQWRGAANSFTSSGEPSVPQVTQISTASVDLHSDMADLRSKEGVLDKLIANCTRQLRTLTEDSENARLAYVTYQDIRGLSSLREQTVIAIKAPPETRLEVPDPDKNIQIWLKSSRGPIDVFLCPDDLPGEESSSGTSSSESTASANDQDEVDGLLSDLGMDTRPEIRPGPSSSADDRLSDKLTSFESIKQELFSDDSLSADNELLKKALLAEEISPSCGSSILHNTTDQDMPFTQIQPTFTFDQGDDYLFVNEESFSDLLSAYDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2B7</accession>
    <name>A0ABM0K2B7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylcholine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107074.1">
        <property type="nucleotide sequence ID" value="XM_005107017.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861230"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18995">
        <property type="entry name" value="LGIC_AChBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046650568" evidence="1">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107074.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26417" checksum="A6BB5169E64D7ADA" modified="2025-10-08" version="1">MLVSVYLALLVACVGQAHSQHNLMRLKSSLFHRVPKYPGPTTDDPVTVTLGISIQDIVKVDSSTNEVDIVIYQQQRWQLDSREWDPSRFGNITDFRTSAEDIWTPDITAYSSTRPVQVLSPQIAIFNYDGSVTYIPAQRLSIMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLRTDTDQVDLSSYYAGSKYEILSATQTRQVVHYSCCPEPYVNVNVVITFRERGVGDGFFSSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2S6</accession>
    <name>A0ABM0K2S6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor mef2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107436.1">
        <property type="nucleotide sequence ID" value="XM_005107379.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847903"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911:SF3">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107436.1"/>
        </source>
    </evidence>
    <sequence length="791" mass="82812" checksum="E1D6770515A47F17" modified="2025-10-08" version="1">MTSLMSQSDYWCKKPAAASPRSAGSGSNPRSLRSSPVAATANTGGGQQGSTLTALSESNTGISSNNNNNGNNCSSGNSNNSSNNNNNNNNSSPAHGNCTPRASPSGSNSRPTSVGPTTSSSTAAGIHHHSHPHQQQSPSSRPASVSGNPSPFSSASSPVGASPSRDYSRPAANSSPGSSYFVKREPSDVGDTSSTGVDNRRQEAEEARAAFQIQNPNAEEVERKYAESLYPAGEGGGGGGGEGGGGGGGGPPGRGSVDKQDAASVREFKFQSFVKTRSPGTTQSRFQPEELGPLPPQAVAVHSGNPAVPQEYIVNGSSLTSGSTVRVLSQQQQQQQQQQQQQQQQQQHHQQQQQQQSLQVQSHASQNILQSVRNLSPSAQADSKVTYSDLQGQHLHHSHHSPSASASTLPKSLPNSSSSTSSSPSSSSSSSAAHHHHHQQHNNSVHHPHESPLSSHLTPLGHQPQHPPAAHLTPLGHHLQQQQQQHQQQQQQTTPGGGGGGSGQYDTSELLLPTEDVEVFFDHLDNTRPVQVMATAQYPSTSDPQGAGSMSYSSLTNSPLNSAGSQHAAMYHPTSRGARLLTLQPSTYTTDPSHIGAQGGSTTYHNLPPMPSLFASSSSRPNAHTPTGSGNGGVYSNNGHGQGHSPSPQHMVSGQAWGPPAPEAVYTNLSSPMSESQKYQYMTLEAGGAGLSLISHAPPRTESVLSRQLSQPPVLDIYSTAAQRVVGAPGGPGIPSGAPYGTPDMQTWNYAVLPDTRAMKVVVTWWSEKSEVIGQYRRSQYSHGAVKGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3U6</accession>
    <name>A0ABM0K3U6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101851531 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101851531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108125.1">
        <property type="nucleotide sequence ID" value="XM_005108068.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851531"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34593:SF12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34593">
        <property type="entry name" value="MATING RESPONSE PROTEIN POI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005108125.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28879" checksum="DD15DFA95F02FAB6" modified="2025-10-08" version="1">MKMAQIIYKLIGKKRVAQIIYKLIGKKRVAQIIYKLIGKMKMPQIIYKLIGKKRVAQIIYKLIGKKRVAQIIYKLIGKMKMPQIIYKLIGKKRVAQIIYKLIGKMKMPQIIYKLIGKKRVAQIIYKLIGKMTVAQIIYKLIGKMKVAQIIYKLIGKKRVAQIIYKLIGKKRVAQIIYKLIGKKRVAQIIYKLIGKKRVAQIIYKLIGKKKVLEIQDNTCCFFPFVTFVRNFLPRGSLVFWVWRDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5C1</accession>
    <name>A0ABM0K5C1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Keratin, type I cytoskeletal 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109116.1">
        <property type="nucleotide sequence ID" value="XM_005109059.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845499"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052644">
        <property type="entry name" value="ZMAT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="943"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109116.1"/>
        </source>
    </evidence>
    <sequence length="1066" mass="110563" checksum="2B138A16B72331DA" modified="2025-10-08" version="1">MSYPDYQYSSYSGSAQAYSGPQYAPPDSGQYAPPDASQYAPPDSQYAPPDSQYAPPEAHSNQYLPPDGQYGPPETHSGQYTEAVTSHPQYDYSYSQPDQYTQTIGSAAPVYNTASSGYLETPAVVSAYTSTPAGYADRTASAYSQPPAPPVYDPPPPSAPAPVTQAYQSHAAPYSADPQKPPAGSYDAGYSYQSEAYGTSQSSYTQDTSTYAQGYDQSSSSASYPAYQSKASYSAAPAGGGVGTWASVSEYPAPPAEPPAAIYSDQQTYSHDYYASGGGDGQGYAQKTEYQRPTWQAAPPVVDSGGYGKEFGGYSGPATRRGGGGGGYTEGQQRSQFKVTGSGVGGGQGYGGYSGSGSGQSGNSKGAEVQRDGGYRNGEGGRSMGGGGGSDFFRGGRGGRGAGRGGNEGVGGQRGGRGGRTYGGSSYGGRAEAGYGGGSDTRFRSEGSSQSSHGDSFGGGNRGGAGGYRQPGGRGGYAGAQGGYSKAPGAKGGSSDGKGFGGRGGFGSSEFRGAGYGSGRGGRDGPPELGGQRGGGRGRDVRQEYGGGGNSGGWVGRRGGQDSGPHEAAYSTNISSRGMARGRGGGANASPRGGGANMSSRGGGANATSRGGGANATSRGGGANKFGGQGSGFDARDKIRPKQETGGSVFGRLGTEEERKARGGANATAAAAVKAPSRPQDRLLNEVEVKPKVERKKTEAELKKEEEERKKAEEEKKKKEEEERKSAEEAVKQASEELRRKAAEEAVKAAPPSKPPQTPEEVAREEEIQQKIRESIVIINPEHEVKVATQDPSKDLEMSQELRDLLKTITGDYVCRLCSVRIVGPHMAAMHYNGKNHMKKLRNFVQTNGRSAGYNLATTADGAAESGGKEEEKKKKAEGENGEKETTQVVDATAGLSEKEYCKLCKVAFQQEVQADMHYKGKNHAKKVRNLGAGGNGPEVFECKICCVTVTAQEHLTAHLNGTRHKLQLRKMDINDAHRGGLRGGGGRGYSFGFGGRGGRGGRGGGGGGEGGSWQDGAEGGRGRGGRGRGRGRADFSGSGFKRPNEEFYGAPSGFHGPTRSKRPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5Y6</accession>
    <name>A0ABM0K5Y6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Sperm-associated antigen 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12" type="primary">LOC101856056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005109509.2">
        <property type="nucleotide sequence ID" value="XM_005109452.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005109512.1">
        <property type="nucleotide sequence ID" value="XM_005109455.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005109513.1">
        <property type="nucleotide sequence ID" value="XM_005109456.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944092.1">
        <property type="nucleotide sequence ID" value="XM_013088638.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856056"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="806"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="733"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="928"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="733"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="928"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="958"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005109509.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005109512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005109513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012944092.1"/>
        </source>
    </evidence>
    <sequence length="1142" mass="125527" checksum="4B4C022D1ACB3E42" modified="2025-10-08" version="1">MSSNIHLEAQTTKKFNLPLSHLDYSYIDKCTNVKELEKIVNVLRSGEEGKYPDLERYAEKRLGELSPKSRTLRKDGPILRPGDLGSGDWKSIEEDLMSWTNSMQDRDAKKGVATLKTPEDVVEQDENLPPVRSNNVVLEGKKQKISSEAKAKRVMPRDYREWDKVDIDAELEKVDKEEKNTQASKGSKLNGVAMDIDATGLSEEQKQMKANREKDKGNEAFRSHDYEESVTYYSRSISLSPLAASYNNRALAYLKLEKWDKAIKDCNSVLNLEIDNIKALLRRGTAYKSKKDYQKAVTDFEKVLKLEPQNKKAEGLLEEVHKQVKKEQKEKGKRMVIEEVEEDSGEEEAETIEVEKPVVNGFGRHKGDEVSSKEVDARSSACKISEIPPEDTKAGEPSGSEKKQITKEEKMTSEKCAQSRSTVTPNEPQGNSTADRKSVVQDTASQCSKKVPVNAASEAVTSPEEKAPNSSALSPPAKASEAASASAAAQSSTLSSSSSSSSSLSVSENASPSSSAATQESQPSSQVSFSLEETTSEAQAKEDAPPSSVNSQFVRPTYVQMPLPPGVLTLKEEGNKLFRSGQYGEAVEQYSKAISKLEKDQDQQVNISVLLSNRAACHLKTGNCSAAVSDCGQSLQLVPHSAKALLRRAAAYETLEKYGDAYVDYKHVLSVDMSTQQAQQGASRCQSTLQQRHGSAAWREKIPRLVLVQPWEVPEIVDQAGLHKSMSSTVSLSEAAAASPKASPETTTLGTATTAPSASEPPASSQPDKGSIAQQNKMATDGAAKGSSQSTSASKKEQTPTKEETFEALKTKGNQHVQKGEFVEAASCYTRCLSLCPDQVACYTNRALCYLKLNKAAEAEADCNQALSFQSTNPKALYRRALARKSQQLYKQSLQDLIDLLRVEPKNTAAKKEMEVVKKCYKEELEKLKQKKQAPDQDTKLRKRMKIEEVDDEEEEEKPVRVKAGDKMKSQSKLRGAKSSQPSLGVKSKGGNAEKKSAETTVQSPPVAPPIAPRLMKTTPYEFCQAWNSLKPCQGIQPYAEILRQVAPVDLASVISNKLDGQMLQIIVRCVYEEMVLKGEVDQGYQILDNLCKVPRFSTVSMFMTSKEKKEVAGVLDILSKTSSSAYSSADVLRLKKEYSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K626</accession>
    <name>A0ABM0K626_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="7">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101852801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="7"/>
    <dbReference type="RefSeq" id="XP_005109585.1">
        <property type="nucleotide sequence ID" value="XM_005109528.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852801"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="398"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005109585.1"/>
        </source>
    </evidence>
    <sequence length="701" mass="75875" checksum="70941ECBA0EEFE65" modified="2025-10-08" version="1">MGSCNTKDYVVPAEQTDSNGYVVSVNGSHDSAKITKNGKSKSKSDKSADNKGFTNDSSASNGNGGVQPVRADTSHANDVVVEQNTERSDGFTAVKADTSRLEEGGAAAADGNTDDQNNGVTPVRADLSHLNDLIVHADQSHLNDLVVRVDESADTSRVDGGASDGNTDEKTGIEPVRADTSRLDDLVVRVHEQSDAFTAVKADTSFLDNLIVRVEDDDSDAIGDIALIGLAVMGQNLILNMNDHGFKVVAFNRTVSKVEDFMNNEAKGTNIIGAKSMEDMVAKLKRPRRVMMLVKAGAAVDAFIDQLVPLLERGDIIIDGGNSEYRDSNRRCKALKEKGILFIGSGVSGGEEGARYGPSLMPGGAEEAWPAVKDIFQSISAKADGEPCCDWVGPEGAGHFVKMVHNGIEYGDMQLICEAYNVMKDALGVSHSEMANVFEAWNKTELDSFLIEITTDILRYNDTDGEPLVTKIRDSAGQKGTGKWTAISALDYGVPVTLIGEAVFARCLSSLKSERVQASRQIPGPAETKFKGDAKAFIEDVRQALYASKIVSYAQGFMLMREAAKEFNWKLNFGSIALMWRGGCIIRSVFLGNIKQAYDKNPELSNLLLDDFFKTEITKCQEAWRRVVSQAVLLGIPTPAFSTALAFFDGYRSETLPANLIQAQRDYFGAHTYERNDAPGKFVHTNWTGRGGNVSSSTYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6G2</accession>
    <name>A0ABM0K6G2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mucin-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109859.2">
        <property type="nucleotide sequence ID" value="XM_005109802.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856933"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015671">
        <property type="entry name" value="GSCR1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15249">
        <property type="entry name" value="GLTSCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLTSCR protein conserved" evidence="2">
        <location>
            <begin position="1189"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1471"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1644"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1561"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1575"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1674"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1693"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1727"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1773"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1801"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1817"/>
            <end position="1826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109859.2"/>
        </source>
    </evidence>
    <sequence length="1842" mass="192889" checksum="43229CAA07F6552A" modified="2025-10-08" version="1">MDADGSGFPFPQGAQESSEPSWGDLFIDGIHADDTAGAGDAGNGSSGAASSQQMIPPSQASVVGGQLQIQLQPQTSVNRVLSDASINIPTHLQGSLPNAAMQQASTSIGGTSTVAYLTQSASSQQLMSTAGRIHNVVSATPQQQQQSQPQQVPSSAAQPQQQHGNAKLVQIAPTFPMATQLSNGVPVQTLLQSNQTLGAQTIYSNPTQGLFPTQGSVHIENPKVVNVNFGPHVIQQDGTGHPAILQTAEGKRLLITNSQLQQMSQSISLTQPLVGTQLINPASGAVGNVIRASLPQATHTIVPSSSSAPRQILLPQGQTVIPRQPTTPQGGLQKNVVLRPLQSNISPVIYQNGQGNVAGQLLQSQPTLITSSGTGLQVVNAAGNQGNQVQLIAQPPINQSAVGPQQVNPNTIMNLIGNQGVIPNSNNQIAGLVPGQSILVNGQMLNLGPLGGLSQLQVQPNTQGIVTLASVNPSVSRAAQFQSNNQQLLIQHSGGQQQQQQQQQQQQQQQVVFQQKIATASPSQAGSVTNLSTQPQRLVQQHKSVARTPTPTANSASSTPTPPSSTPTPTNDLMADLCGSGGKNQSNILEQALSLSDIDLRSFEDDFGFFDNPGECLAAVTTPPPSVTPVPPAKPKPPPAKSKSKSSKSKLKQQQQQQPVVAMQANNNTSLQQPPAAQLTNAKGQKVTLSPQQRLITANGQVYVVSPNGQRLILQQSAGGGTGGLTSPQVKPVVTSQAAAGVGATLDISAKPAAALPASSTTVHIKGHPQQALSLGSLTTSGGTQLKLTPNTLSQKNLLITSNAHTGGHHILIKNSPRVTVAAASAAVGGQALAKVEAGHTVTSSQLVFTTASTMSGSAITFAQVGQLQSSSTAGGQSPRLPLKNQKISTLGGTFIKQEPNLAVVKQEPPSNVQTESLAALSPSLAAIDTSSSPLPSRPLAVTTSVVVTATMPLVTSSASFSSVATVTSQAHLPTIMATTDSLPSVGPQPAPQSADTVAGAVVPGVAMDTLSLSDSLPLPAPSGVSVSSSPGVAVVSSSTSAATSSRSGSELVEKVEEKVVAAAPLGQGFKPEVQQLSEGDTAGQVQAPAAQLAATLPQAGKLAASSLAGNMAAASSSQAAGNMAGGSSSQAAGNMASGSSSQAAGKVAASAQGASASIVVLSQQAASTQQLVFQQMGRCLTEQQLLRDRSLALGPDTNTPFKSLSDAMRRLVRYHTLQDHKPQEESTDMGMWDTRYNKLCDYLQKKKRCYLRRFSKMMLYQDMCAEKGVDSFHNLACFNQQMREDLELAKERAKTCPDSCEQLRQEYMAAAAVGTATAAAATTTTTAPSSPGSPGTPSPTPQKSGRLLVEESDSEVCLDRRRPMASHWLEHAELRPPGPQAAAAKSVPDGSTASRKRKHPGDQITTGTLKMVFKRNTTDNFVVKNSLEGSGSVPKDLKPVVNLEKSDSEYEFDSRHEGLNNQPVLVRRRTSSISLTSRQTSLEARSESSSQSSFHKGSRRSSEGEEEDEEDMDDDEEEEEEEEEGEEEDVEEDDDESESESRSSISGKLSKEEVHQSSYEDVEAEAENDAFETDGQTCGHSVVDTQDQRPALKLASLKTTAQLYSNITSISEMSQDSGSKVKRRLSRVTRDFSEISDDVFTPDLLYPGAALNDEGADPGPGEPGDNMDHSQVRKQSTCTSHSTGGGDHKQLAASACASPAASANDEEFVAESPVSNMEKEAAQRGLPNTSLFSSTNNRTLLETEDMYSSSDDEHHNSRPSGFASFEIDNRDPQNSMINDSVRSAINSVLNSDDDDDDNSHMSWSSTARPSSHHRSAAGSRRSGSGNKDTDLDAAVQSILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7N8</accession>
    <name>A0ABM0K7N8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable rRNA-processing protein EBP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the processing of the 27S pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110722.1">
        <property type="nucleotide sequence ID" value="XM_005110665.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846039"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005110722.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33500" checksum="C02E700257B4BBB8" modified="2025-10-08" version="1">MMKGFAPDSNFESDSDEEIQEALAAGKIQPGLIVEAQKKNFIDNKEGLSDKIREFSLDKMKWIERLELTNNPAPSIDALTSEGNEDDDFNREMRFYRQAQASVLEGLARLAKLSVPTKRPEDYFAEMAKSDEHMKKVRSKLLEKKMSMERSEKAKKLRELRKYGKKVQHEVLLKRQKEKREMLDSVKKFRKGQIDKIELLGETVERETPAQQTQNGKKNMRPNKKREFKNKKFGFGGQKKRSKYNTAESSADVSDFNARKAHGKGPARKGKGNQRPGKNRRKVLKNKNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7P0</accession>
    <name>A0ABM0K7P0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fizzy-related protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101846612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110725.1">
        <property type="nucleotide sequence ID" value="XM_005110668.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846612"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="6">
        <location>
            <begin position="166"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="426"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110725.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="53463" checksum="7B73499B08F13974" modified="2025-10-08" version="1">MDPEYEKRLLRQQNGQMAPFGMPMFASPVVSPSKKIYGDRFIPTRASPCWHINFDLNQPQTPSSTLKAKDSNSETSKDGLAYACLLKNELLSAGIEDLKDLHTEDKKVLAPKETKNLFKFHTPRRCSDGCDVSPYSLSPVGSKSQKLLRSPRKAVRKISKIPFKVLDAPELQDDFYLNLVDWSSQNVLSVGLGTCVYLWSACTSQVTRLCDLASDNDTVTSVSWSERGNQVAVGTNKGYVQIWDVSVSKKVHTLTGHSARVGALAWNGDMLSSGSRDRLILQRDIRTPNSTPERKLIGHKQEVCGLKWSPDHQHLASGGNDNRLFVWNATSTTPMQHHMEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTNQPLHCVDTGSQVCNLAWSKHSNELVSTHGYSQNQILVWKYPSLVQIAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESKSVLNLFTRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K880</accession>
    <name>A0ABM0K880_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein HEXIM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101863148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEXIM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111113.1">
        <property type="nucleotide sequence ID" value="XM_005111056.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863148"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024872">
        <property type="entry name" value="HEXIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469">
        <property type="entry name" value="HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469:SF8">
        <property type="entry name" value="HEXIM P-TEFB COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15313">
        <property type="entry name" value="HEXIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02094">
        <property type="entry name" value="HEXIMFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005111113.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35253" checksum="14A1BCC32F242D21" modified="2025-10-08" version="1">MAEVATFNEGVSSIEERNHENKLQTGGQEHPDSPDGDEYSSGSDRSYEGEDGDGGCGESSTPTKSENSRARRRRRHGSHGSRRHKGGSRHKKAFQPYPPQDEMKLKRRTLERKEKENAAAVVRREEGGQEFIRFPVAPFNSTQYLMDEHNVNSPVGLHKTPSSSKLELCSNSSPAPASVHSTPMHYSQGIMNLEKKDKEFVDIYTSVHAESLQSLPKEELVKHYMSLEEKVESLQKEMAVVKQRKLEGVKVDSREVDKDFACDSVSGSDTNSLSSSNEDFVDLSTVNQPTISVGETDTPMAETRSSAATEASKEQETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K896</accession>
    <name>A0ABM0K896_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CUE domain-containing protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CUEDC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111138.1">
        <property type="nucleotide sequence ID" value="XM_005111081.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849972"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14367">
        <property type="entry name" value="CUE_CUED2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039805">
        <property type="entry name" value="CUE_CUED2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12493">
        <property type="entry name" value="CUE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12493:SF0">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005111138.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43149" checksum="A25FF401BA268AFD" modified="2025-10-08" version="1">MEARVHKELSTFLERHSLGGSISNIDEIVLSYLLGIMELIGQGEVEDCFDLEDVMEMMAAYLPGFEIVDRSSVMEWMFSLSSQLAKGEDTASETACPVKEEETEQRDADEHNSQTDTDSKILHGSIGGKDSKFPSYDFTESASSPPLPQMSVMPRLTDIKDEPSPDPDTNKESSRPAEWKKITSAKSETITFAPVNGLYAARDKSKNSKRKGRQLSCSSQESQEDAVPGRAEVVETGEGQVRSLLEMFPAACTMEARHCLQLSNGDLDLAAQLIIDRQETGQALRSQAKGTLKKNAKVKKSCDYKLDDASLKSSVLQKYSFIDTEEDKKTYKPPPLKGEAKKLVRYRDGQIVSVKGERFSEVKKKDSEEMKETYVNLKPARKYRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8R7</accession>
    <name>A0ABM0K8R7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Methylmalonic aciduria type A homolog, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101861627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111521.1">
        <property type="nucleotide sequence ID" value="XM_005111464.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005111522.1">
        <property type="nucleotide sequence ID" value="XM_005111465.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861627"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03114">
        <property type="entry name" value="MMAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006958">
        <property type="entry name" value="PRK09435.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408:SF3">
        <property type="entry name" value="METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03308">
        <property type="entry name" value="MeaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005111521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111522.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="49387" checksum="FF56C6A24B78A4D8" modified="2025-10-08" version="1">MFYMRHSVKVCAFHYQWASRSTLSYNRMLCSRFVASSVLSQRPIVSSVKTCLYNTFLFQKSSLFHLCPLITTVNNVQGFLTHSVCLSSRYGGASASSLDVNNLLGEVKNPGAIESLFQRLIAQDRASLAKAITLVESTHPQRQKQAQLLLTKVLSHMREHDQHHLKGPRSFRIGLSGPPGAGKSTFIEVFGKHLTSIGHRVAVLAVDPSSSTTGGSLLGDKTRMPELSRDMSAYIRPSPSAGTLGGVTRTTNEAIVLCEGGGFDVILVETVGVGQSEFAVADMVDMFCLLIPPAGGDELQGIKKGIVEVADYVVVNKSDGDLVPAARRIQAEYTSALKFMRPRSKVWKPKVTRISSLDKSGIPELWETLKEFKNLTLAEGELTARREKQLNLWFRSHIRDHIMGRFERQPHIQRLLPEMENLVTRALVTPGLAADYMLEQFLGGSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9H7</accession>
    <name>A0ABM0K9H7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">G-protein coupled receptor GRL101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101862918</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112105.1">
        <property type="nucleotide sequence ID" value="XM_005112048.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862918"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="863"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="911"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="996"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="753"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005112105.1"/>
        </source>
    </evidence>
    <sequence length="1119" mass="123740" checksum="1047BAC72FE48EBB" modified="2025-10-08" version="1">MWYKAVRRDPVLPLAGTFVLNCSGHETSLPPDIICDFRDDCQGGKDEVNCAYVTGTPWCPGGHVFGSSCYHLLAPQWKGTWQKAENMCVQQYNGHLVTPNTGRELQFLSHLIFLKFQYSFATLWYLGFRRRSFGADLLYRKVYQAVDGTSVFGGFKQQFVSDVTAACALWDYTQIFNLREVTDIPCYQVWTVRKSDAEFSRTIFQRQNVHIVCEVKKTAEAKPLVTSSSAAVWTAKRETFECVVSKERVSLSRRCDWLSDCWDGSDEVGCAGLSDVPSYVRFTCTSGRPLWYSHVCDGVSDCVDGSDEEFCAPASDDNSALAVCDDGVPVPASAWCDAKPDCLDASDELDCSRCNGGALLCPSVGCLPPHWAHDDALDCHLRDKSGQWILEPDFVPHTLDARPPPGVVRPDGYGKVTIEPLDEGEPCPPTHAQCPKGYCIPIHMLCNGHTDCPEGEDELAETCQSFCEGRYKCHQTSMCLHDDHVCDGWFHCPLHDDETFCWTNDTCPPGCVCSGEEITCRSGFTIGDFVRVRRLDVSHTARPNDSLTVQNHYIIALFAHNSNVRELGLLGMTNLYHLDLSDNALRNFAPDSFEKSPGIRQLFLARNELSETDLQPITSLKNLEILDVSGNAQVRIRSSSFTGLARLRSLQLDDMGLTVVETGAFDGLLELRTLTMRGNSISVFQQGMLLGLSQLTSLSSDNYKLCCPVMKPKSLSTGTCQAPKDEISSCEDILRTPFFRVFLWLVASLTILGNSCVLVYRLCVERKPSTLGYNTFVINLSASDLLMGIYLAIIGAADQVYKGRYLWEADSWQSSSYCSLAGFLSTVSSEVSALTICMVTLDRYLALAFPLANVHLTPKKARCLVLVTWVVGVLFAGVPLLPPLSHWRFYAQTAVCVPLPITRADFPGRDYAFSVFIVLNLALFVAIAVGQVLIYRSVKANSLKMTAAPISRRNQDTAIARKLALVVITDFLCWFPIGVMGLLSKVGVPIPGEVNVVATIFILPLNSALNPILYTLPALIQKLEEWQARPDPNKAISAGFRLRSKDLPQGNVSSSSRQCKSGYRGISRSARGPDDVTRSQVCLATLRVWLETGKVRRAAVRQILSRYQMDNPSSSASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBB0</accession>
    <name>A0ABM0KBB0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General transcription factor 3C polypeptide 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101853439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113480.1">
        <property type="nucleotide sequence ID" value="XM_005113423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853439"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005113480.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16327" checksum="A7EA070536850C4E" modified="2025-10-08" version="1">MGLKQETASIRWELFIIKMSGSPRVYMDVEGWQRYLPPLKRHNSTFVPKKDGVCMVGDLLLHMPLCLYCSVVNVGWKVDGLKEALADPETRLYPLDALPCELLSPLLYRRKYIARIVDSIQTLCQMGVVTFSPKGIKRDYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBH5</accession>
    <name>A0ABM0KBH5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Adult enhancer factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101860075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113575.2">
        <property type="nucleotide sequence ID" value="XM_005113518.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860075"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005113575.2"/>
        </source>
    </evidence>
    <sequence length="386" mass="40464" checksum="0EEB1FAF972D3548" modified="2025-10-08" version="1">MSSGRGRPPSMGSAAQQHSLEQQSLPPHLRALSEHPAHPHNALVEHHTPGGMDGGGGGSHNGRGGLSAYGLDNNGPLVGSRPSSLLSPEAAAHSSRPDSHPLSRSVYSSSSLPSSADRPGSGQQQQQQHHHHHLVTSASTTTSLIEETIAAVASNFGKSPSIGGPIPAGLSHTPHSMMSHLGALGLARSSLAGAGGGGHHMGGSGGGSGGGGGAPGDESLVDLVGRHQSHTIPMLSERASQSLSGLMDEHGALHAPPSSVSGSSSGGGGPGSQLEKTHPCLTCLKMFRSKQQLAQHSLVHTGIRKHICSYCDRAFKQLSHLQQHVRIHTGERKYSCQQCHRGFKQLSHLQKHTRIHSGERKYICSICEKGFKQLSHLQQHFRIHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZU83</accession>
    <name>A0ABM0ZU83_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934564.1">
        <property type="nucleotide sequence ID" value="XM_013079110.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854235"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012934564.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14631" checksum="8BC96BADDE1848BE" modified="2025-10-08" version="1">MADALFKELPLRALGYGFAVGEALVYVASSRKIDICYTIGACFIGSHCIYSLVAPDGSPAVSLLRAVLWEGLASYLFPTLIVYHASRLTFTLLDETKLPSGTKRWVPCLLGLAITPFLMQPLDELCDNMVSSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUU5</accession>
    <name>A0ABM0ZUU5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859625</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934907.1">
        <property type="nucleotide sequence ID" value="XM_013079453.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859625"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012934907.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15304" checksum="A47CB272D515146B" modified="2025-10-08" version="1">MCYNKLAPTLCRKFCNLCHYPALSYNNSIPTQHPPPATAQTNTSAATGSVTNRLTTAPTTPSQPASTTTATPSCVDHFKDCATAPSMCQNPYASTICKATCNYCPVTTVAPAPCTDHLTSVKCTDIPNVCLNVLAPVACPKTCGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVD4</accession>
    <name>A0ABM0ZVD4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106011166</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935266.1">
        <property type="nucleotide sequence ID" value="XM_013079812.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011166"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046888678" evidence="2">
        <location>
            <begin position="30"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935266.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29045" checksum="C7D350845BD3FD77" modified="2025-10-08" version="1">MARLSIVSNCPWLAALGATFVFIVAPCLGCSPPMGPGANLPPTLEYKMMDSDVVAYGVPIKTEPDTRFPGDSVYVVDFQVRCIFKGAPLREVIRIYEVGVIPGKCLATNMTVGETMLVYLERIGDKLQPSYVQDPGDSQYLDEVVVLCEATVSYPIGYGPDNNKETCPEEYEYDDCVPIPTPTTVLPPPEPSPEPELPKDDKTPPPPPEDKSKAGEMPADTPDTEEAPYKPVSSNDEDSNPTDPENSAATFTLHLGALLCLFLSAMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWC7</accession>
    <name>A0ABM0ZWC7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multiple coagulation factor deficiency protein 2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935888.1">
        <property type="nucleotide sequence ID" value="XM_013080434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011295"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052110">
        <property type="entry name" value="MCFD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104">
        <property type="entry name" value="MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935888.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11139" checksum="9286DF9F2CEBDD40" modified="2025-10-08" version="1">MQGQINTDKSMSPAEMEFHYFRLHDTNNDTMLDGLELLNALSHMMPPMEFAPHEINGKPAVEVEQMRKDRVREMLTNYVREWSKVVKIKPFESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYI8</accession>
    <name>A0ABM0ZYI8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011587</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937177.1">
        <property type="nucleotide sequence ID" value="XM_013081723.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011587"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937177.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20013" checksum="11A8F2470F2ED4D8" modified="2025-10-08" version="1">MECEAMSLEAPSSQGCDVTSHIPNAPPAVSAAAVAATAAVAAADTVAGTSGADDVEEVTETKIIGVTETGVIRKRSFKRKVRKEETPQRMSFGQDKDVYRKIVDRVMNERLVSGTLEGLQERWKMISYMHADCMDMVTQWEKKREAKLQARRKDPRLYMLVAGGSAFVLFLLWSLVRCIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ16</accession>
    <name>A0ABM0ZZ16_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Temptin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC106011646</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937462.1">
        <property type="nucleotide sequence ID" value="XM_013082008.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937463.1">
        <property type="nucleotide sequence ID" value="XM_013082009.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011646"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057626">
        <property type="entry name" value="S-S_Temptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055313">
        <property type="entry name" value="Temptin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24784">
        <property type="entry name" value="Temptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021891" evidence="1">
        <location>
            <begin position="27"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Temptin Cys/Cys disulfide" evidence="2">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012937463.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="13811" checksum="D62C0288DAB10389" modified="2025-10-08" version="1">MHLSNNSILPVYLLVLAAVGVLVSDAYPPYLLVVPNGLFVRDQCGSIVVGLGHIDPLGGGLNNQFGLDFAAAGHAWTKELCEKDSDGDGRTNGDELGDPDCEWMLLGVPSRTESITNPGVNNNFPVICLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZD3</accession>
    <name>A0ABM0ZZD3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/threonine-protein kinase pakD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101861659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937653.1">
        <property type="nucleotide sequence ID" value="XM_013082199.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861659"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NR LBD" evidence="9">
        <location>
            <begin position="370"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012937653.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="72433" checksum="E01C0113511F38D6" modified="2025-10-08" version="1">MCLAVGMSKDAVKIGRYTSETRTKNIIAAKLAREEQQQQKQQQEQEQQQQQKQQKQQQEQQQEQQQEQQQEQQQEQRQERQQQQQPEVTGGCDSNVVLVYNKNSVSGLQDDGLGFSATVKEPAVENAHDESAKHNTNCRLTSDKSPLIPFDVLEPFDFGGISFALDTSLTNESGAVHLQTVDSDLNCPSARSLPHVTMHNPPVTDSNIAPSQDSNMLPSSPMFDSFSSSPELLYDLSPRPHVTLNMMEFQETLQIPTTSATTGQVVGEDYQDFSRLAPELGFENLSLLNSPSPSTSSSSSSSSSSSSSIDEKSTAKETEDQLVEAIKAAYTMCHPKSATQHFAIVKRFQILNAARCEEVTRPICGSTSHQLDTIIHDLILSHNRTLPDCTYLPTRFMHNMQSSYLEGFRLKQSVFGDAHYFVPEEQIFEIYKKTGLDIDGRIHRAKSCIVYFEQSVRSIIKFAKTVPGFRDLCLDDQAMMLKRGGHSVLFLGRYRGFNLDLDVECDAIGLCRHRKVLYTFYSREFVDTIFEKAAVLQATVMQPEVVVILKALALTMIEPEMNIQNPKAVESIQNLLFSCLQRSLKISQPDTEPLALVAQAVTNLNLVRSVSELEPLHQNKFIWKEILFQNPLIKEVVWKGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZN7</accession>
    <name>A0ABM0ZZN7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase family 42E member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937841.1">
        <property type="nucleotide sequence ID" value="XM_013082387.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856022"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937841.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16865" checksum="3878DECAC9570250" modified="2025-10-08" version="1">MVQTRSSAQSRDKEIHVVTGGGGFPGFSLAKYLARKGHHVKLIDVKEPVWDLEANMEFIKGSICDDNQLQSVVEGASAVYHMASYGMSGREQVGHHPSLPLHNRIAFDIICFLSMTSCAIFFIISTTPTPPFFSNLHFVPSQISGSVSEIVCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0C2</accession>
    <name>A0ABM1A0C2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101852851</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 20">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012938236.1">
        <property type="nucleotide sequence ID" value="XM_013082782.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852851"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14549">
        <property type="entry name" value="R5-PTPc-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046647012" description="protein-tyrosine-phosphatase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="137"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="265"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="357"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="457"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="678"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="866"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="985"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1272"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1279"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1315"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1336"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_012938236.1"/>
        </source>
    </evidence>
    <sequence length="1345" mass="150299" checksum="D2F3A11FC3C122D2" modified="2025-10-08" version="1">MDIMKFSGCCVLVTVLCCVALSGGERVAVPLGHNVTLQCTPVGPEEQFATYMWTLNSVLLASMGKDRLVNIVAGSYVGKMSMLPVDGSLTVLDLRMEDSGNYTCGLVVMVTNETSGDVSFPNMEKTYEVVVQDVPSSPNEPVLRDIQSSQVTVTWKASPNDNNSPVKAYILSVKECTSSLGATPVIVQELRTPSSVLAKTVQGLQPFTCYTVNVAAENAMGLSLPSRPSQEFYTEQEDYMADADSTFFINTTDAVNVTIKPPGVAPYNFVASGISSSAILLEWERPPDDLLNGQLMGYEINYGTEVLKTINIEDPNKVNTTLEGLHPFTMYRVFIKAYNSAGPGPEEAQMVQTKEGVPSKPRITHISNRQSNSFYVNWEPPVRLNGQLIRYELTWMHNNTTMPRSITGHLIKHMTAFVQGLKPYTLYHVKVAAVTNGGLGEFSDPFPALTDVAAPGPPRNLNITMKGPRSVLMTWEVPKVFYKNVDNYLIKGWDNRGQDVKVEVMGHLTEYNLTGLRMNTRYHLKVAAVTNALFSSNKWVGDFTKVQKFDIGENVIDGGNVIWDRDYGNSHKDYDPNAVTGTEPDSGGIGAGIIAGIVCAVVLLLVVVALVVGYRWYTCRRCYQAAYLYLAVPSNGQSVQPAIIHVEEPSEGKQYPDIPVEDFLGHVNQMHTDSDIAFAQEFDEINRASCSDKYPCDHSNHSENRNKNRYVNIVAYDHSRVVLLKAEMGRLRQSDYINANYVDGYKKPKAYIATQGPLPQTFPDFWRMVWEQNTSVIVMITNLMEKERRKCDQYWPSDGVETYGSMQVKLITTVPRAHYTVRVFSLRNMKVKKRHSMKASAERTVYHYHYTEWPDHGVPDYSLPVLSFVQKSAAQSGPEHGPIIVHCSAGVGRTGTYILIDSMMAQIQDKKSINIPGFTQHIRRQRNFLVQTEDQYIFIHSVLVEYLLGGGSTEVRDEALMDHMDQLQRPSKSLLLPSLTTSSLLERQYQLVTEYTPSEQDMAAALKPFNQEKNRLGSILPVNLKRVLLPARPGVEGSNYINATYLQGYRKSAEFLVTQHPTVDTMEDFWRMVWDKNSPVIVVLSEFDDIEYKEFWPPKGSSIEVDAGNFRLTMKEEPVANEGQGFVTYEFILDSIQYDYTLMTRIICVSGWPSMWEGHSVFSPICHAFDFLNSLECGPIVVMDRFGGVEAGQFCALWTLRDQVLSEKCADFYQVAKLYHYKRPGIIGKQEDYQFLHRAMAAFYKHCREEHAANGSSSPRHHHIDIFHHNSARKNGTLPRSNANNNAAPAPVSNSTPSNITDAAVPRAGTRIGRSSSGDSVANSNGNNNPSTPTNEEAKKTETNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0H7</accession>
    <name>A0ABM1A0H7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011842</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938335.1">
        <property type="nucleotide sequence ID" value="XM_013082881.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011842"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938335.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="44150" checksum="5FC8DEF35706AA3D" modified="2025-10-08" version="1">MAFTGQGLSVNFKTTGGIGLYISLVVTLTSFFTLTTGQQQPPQTQNVCSSRFEAALAPQCFESYGVNFTGVIYVLSANRSGGIPPTYTYESFLEFLCSVSMQDNIIPCVLGQMQQFNSTQCTEQDRLGVLGRGGQLLAFMDAICGAPCEQEATQSMIQCYAAIDVNPDAILSPNASIADDKYTIVGTNETQYENFCNNRQKLFSCLSPLTATCPGLLERLYTIGVDLEAMEAATGLLCKDKAKFFEGLNCFTTPTSSVTQCRQSTETNMREVLVGRYQTGAVPPSKYMDKLCESKLTQVDCELQAFAQSCDPDISELRTSVECAILPRPCKDAPAFKQVYNGLCKKVTTPTPVTNRPTVPSGGPGKVPGTSDDNGSNRDDDDDDDDSSACAVAMSMSVVIVSVVLNVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0K0</accession>
    <name>A0ABM1A0K0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101858630</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938382.2">
        <property type="nucleotide sequence ID" value="XM_013082928.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858630"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="667"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012938382.2"/>
        </source>
    </evidence>
    <sequence length="729" mass="82046" checksum="9C09CB9D8804268D" modified="2025-10-08" version="1">MEAAVLEAVRSLNCDLVLELLPDSSQQPRLSGELIRSVFLTAVSSLTHNRATGPQASRMIYLLRNLGAHVNRQDQEGNTPLLCYLKAGSPDYDVVEAFLRCNADVHLANKKGESPLEVVSKAPGVPPAVRDLFRRYVPGIWEAVTSDDAMSVRRLVNEWCRVDVQKNGKTLLQMALEMGTESIIRVVSGIRPSMEFAHSVLSGDTLMVRRMLRLKLKININFRNLGDRGKTPIFYALTQSNSEMIHTLLDRGARADVALKGEDEVSSPHMDIPMFFYALEHRPAINTVLLKAVTPMAPIRIDALFYKGRNILFHCVDKDVGEDLVEYLLSKSSAYLVTQRVELNKCARDLALESGCLWMVQAIDTAVMKWVYQEEGLNRQIMVLHGYQHIPAALQSSQKEESEDTFYRYLSMYQDQVSSLHTAVEESDEETVRHIIYFRHPDDHSLDPCLADSRRPGDGQPLLHKAVLRGSVGVVQLLAETLVYQRKQRLDSIRDQYFRTALHYAYGLEQGKELVNLLLDYGASEFTMDKDNRSPLAFKDRRGQALMNDLLEYHYLQDFSEPEPDPWSIPMPIPMIDYLLTACPHSGHTSYLSSPSLEHLTSHLTTGHCITSLPSTELATTESSHPASPLAKSHKYKSVSDTKLHRLTPAKPGLAAQLANFPDAVKSRLSKRPHHQKNGVDGVHKDYLPLPLDAPRDSEDDYDYEEDGTDSKDLLDEKELRKSTSCTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0W6</accession>
    <name>A0ABM1A0W6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iroquois-class homeodomain protein irx-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101847264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938568.1">
        <property type="nucleotide sequence ID" value="XM_013083114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847264"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF40">
        <property type="entry name" value="MIRROR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="148"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="717"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012938568.1"/>
        </source>
    </evidence>
    <sequence length="742" mass="80784" checksum="227AE23D891427D6" modified="2025-10-08" version="1">MFRAGYPLPVSHGEVQMSSKSLSATSSPLPSGAMCEDGRPYVTDPITGRQVCLCNLGVDTPPYGPPRSAAAGDGLKHASLPAAAGVGTTPHLTFDPSAFYPPLVRGLPLRQDRLPPYLTAGMPGQPPVTFDPVLAAHPYGLLYAGMDMAGNPMRKAATRETTGPLKAWLSEHKKNPYPTKAEKIMLAIITRMTLTQVSTWFANARRRLKKENKLFPGDRDDKDDDDEDDEAHRREDGESVHEGNSINTSGPHKPAPLDSDSEDINVDSSDNSDDEDHPNSSHHRHITDAKSPHLLSQDKHTSSLSDFSFQSLSAEQRGLLRHHALDFSQSSLQRKTDGNVYKLTGDNCKDDDVISGSRHNHKQGDINNASSTLDSNSPLKKSNSLSSKPKIWSISEIISSPSSSTSKNSEAHQKDLDSTREYCNYTPPLPQTQSKMKLPSSKTSHTPPTSPGSEERSSHQFSPGADNNYLSTLIYAHAPTQHPAHSSFKHYTVGSMPDLRHSMSNHTVRHSELSLSPARWGSSELRPENSLVRQRRLLQQSSSPIAPCPQKTHETVRGWMAKNEDYIIRCRNALSLDSAKPPSSTSGSMEHHSQHPHSDVTSSPRRKSVGESFSSPVCGSEFGKHPLQIPGSSNTSTPSSYMDKGHSSSRTKSVISSPVSPTTLVKTSTLTGVPCSEPSRNMSMTPEDNHIPTKRGKLTAPGPERSEVLSPHRRENGTFNSNTSDQDSNDGISGTDNMMSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1D5</accession>
    <name>A0ABM1A1D5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitinase-3-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101851415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938855.2">
        <property type="nucleotide sequence ID" value="XM_013083401.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851415"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046489468" evidence="6">
        <location>
            <begin position="24"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="26"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012938855.2"/>
        </source>
    </evidence>
    <sequence length="458" mass="52092" checksum="297C0302F860E07D" modified="2025-10-08" version="1">MVLQRNPIGLGLVLLMFVIASECNEFLRVCYFTSWSVHRKSHYAKFDVADIDPSLCTHLIYAFGKIDVESKLLVPFEPLVEDARPGHIGKYGQFNKLKQQNPRLKTLLSVGGQFDDGSGFVTVTENDIIIKRFAQNAVEFLRKRSFDGFDIDWEYPTKETKRTFIRLLRVTTRPLSFPISSLKDQNSPPPEKSNLTHSTPNMVMPQLSYFDPSERIGVTIGVTAEYVDYANLMTYDYHGHNSQVAAFNSPLYSRKDPTFNPTLSTNWTVHYYNRLGLPLSKILVGVTPMGRQFILVNTNDTFVGAPVTFEEEPGNFYDMEGRLAYPEVCQMRFGVRTKKDFDIEQSVPFMWHGHHWVGYEDTHSAKIKVDYMLKTGAAGFMFWSLDQDDFTGLACEVGKYPLLKAMVNSVKKSEEPVLTEHVNDEINYLTQGARPTSTSLSFQVVIVLSVIAKTLMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1R4</accession>
    <name>A0ABM1A1R4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106012019</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106012019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939061.1">
        <property type="nucleotide sequence ID" value="XM_013083607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012019"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045707014" evidence="2">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="3">
        <location>
            <begin position="198"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939061.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="26928" checksum="6D3580014B6681B8" modified="2025-10-08" version="1">MLWYTAIVLLFLAVPTHGLTVFTSDDDVTECSVEAPCEDAEEMCRKVQECIVASCPVTSYCLECVPQGVDSRCINAQYQYAVLVGSALDPVGLRDRPCDQENNRCPDGATCVFDVADSDVGVCCYGSLDASSPGNTPSDDSDDDFCSIPEDSHCGSCDAGHICKRVLENDDDDDGDDDDDDDDSDSEEADYECREIVNDGYCPSPLFVGTPIDCPPGGSDISCRGDHDCSETDKCCLNICGGRQCTTSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2F7</accession>
    <name>A0ABM1A2F7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">F-BAR and double SH3 domains protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101849298</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012939475.2">
        <property type="nucleotide sequence ID" value="XM_013084021.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849298"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11761">
        <property type="entry name" value="SH3_FCHSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11762">
        <property type="entry name" value="SH3_FCHSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035460">
        <property type="entry name" value="FCHSD_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="11">
        <location>
            <begin position="118"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="536"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="691"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="628"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="757"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012939475.2"/>
        </source>
    </evidence>
    <sequence length="822" mass="90353" checksum="15E8FC604919110F" modified="2025-10-08" version="1">METSSVSGTRHGVANEVDADSQRHGPICVEAVTCSTRFGSASTDMTKYPFHLRDLFCLDGAESKLGNDMDAYRINVYSTGRVTSLLPVVIKSMCKLNVLMFPFDTQVCFDLNTLRLGEGRTVCTVWRSVLEESDRLARARLQAAEVYAEKAAEPLKPTKAAKVQCFKKVMPQLSTIQTEVAQCVMDLVKAQKLYTTEGGVAYEARQKSTEAEDKLKRKSTGIFQSLASLQKSCAKLRSRTEASEVKETSARNEYLLCLAAANAHHMRYYSTDMPDILKTLDCDIYEKIQEALTVAGQTAADLAEAESSSFQTIAVEAAKICRQFSHQCYLFQNPVFTNLVQYQFEPTNGDTCNKVSSDHGAGPELEKEARKWCTKIAKETRAIRDYYRQMTVIHSMRSGDRVSESGSQESASTTDPEVKLEELRHNIRKAETSKLKAEARLEALRSGGDPRYDDLIPRLMEIFMNVDEWMSQAQMESLVAEESGLARTPSQLSLRTESSGGQSTDDHEPTYTHYDDDDDFIDDTFNTTGGTRSGRVYPIYCKALYDFEASNYDEMSIKAEEELELIADGDGDGWVKAKNSLGQEGYIPETYVDLGGLSDEPAPLGVEAMNAINDTVTETTATTIAATATAPAPPAAKSATPDLQSPTSVDLQQDTTSSYSSGDLEVQQTTEVMTGEEPQIPVTVVTSAESTETSWARALYDYEAQTEEELSFLEGAFIKVLRKDDNGVDDGFWEGECNGRSGVFPSLVVEEIVDLSTPQDPLSPGGPDFSIPPPVHVTLPTPDAEPPPPPPMANGEDFKVFRNLYTSPGEDSTTPTADQSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2F8</accession>
    <name>A0ABM1A2F8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endo-1,4-beta-xylanase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939479.1">
        <property type="nucleotide sequence ID" value="XM_013084025.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860746"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.690">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041254">
        <property type="entry name" value="PCSK9_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041051">
        <property type="entry name" value="PCSK9_C3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF1">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18459">
        <property type="entry name" value="PCSK9_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18463">
        <property type="entry name" value="PCSK9_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="7">
        <location>
            <begin position="296"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012939479.1"/>
        </source>
    </evidence>
    <sequence length="911" mass="101209" checksum="CB9309B71407EC32" modified="2025-10-08" version="1">MNSTHQTHSSLGHQRSTVWSPLLHNMGTTKEGLLYRNIRILNVPVFVAIFVLVISNGVVTRAAVELLKNPGFENGVTSWSHNGFSMVTTTDQVHEGRVAVKCTGRTQSWMGPAQDIQISRGKHYVFKSYIRLINDLPGRMFQKAVMKISFTLKDGSKNYFPVCSRPYLTTADGWTMLGGDFIPPNFEWTQASLYLEGLLPGTDYYFDDASLTELPSNPNWEREANERIENFRKSNLHVNVSLSSGFRPDDVTVENCIVSAVRTTLSINEIATTKKTPETISLDQINHLKHLFAWGSVVKPDLFLESDYAQYQQVYYHMFNWATVQDYKWRFNRGNRTNPDYRVAVAATDVLNRNGIKVRGHCMFWAVPFNNPEWIKGLSAQEFKTTVDDRIAYMTAQTKNKLAHWDVNNELLHGYFYEEHSGNPLYTEHMFREIHAADPKPTLFLNEYNVVKSGEMTQSYLTQILKFKAANVGLGGVGVQSHLNDYEEPNPDSINYRLNVVAKGGLPIFVTELTLGVRDPHTKADWLERVLRLYFSHPGVHGVIFWGFWINDNVFRQLVQGSFFTLNESGKRFLKLTKETWSTHVNQSLASGTSFNLRAFQGDYEAVVWYKGKPIKRTTFSLGTQDKTVSISVSGNGNAIQLPKKIDPFSMKVQINPQTTRANLRTLGQASSTSQNSQLTCTTRRSPTSAVGVSKTTQVTCQGDEILTGCSSWLKDSDWHRDGEEILMSGGKQACRAMNGYGSSAGVEAVARCCSAQGLKCEYRTAGPSGTGMDDKVEVPCQGQAYALGCSTLAYSHNSDGSIFTNTSCMGQNDYPRDGVYSYAACCQSPNLQCRTVTSGTSGKKQSDQVGVTCPKGYVMTGCNVFSQYGKTGGAFINPNVAGTDTCVAVNGAEKFGPETGVQAQATCCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2S5</accession>
    <name>A0ABM1A2S5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101845108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939677.2">
        <property type="nucleotide sequence ID" value="XM_013084223.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845108"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033182">
        <property type="entry name" value="MIC26/MIC27_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14564">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012939677.2"/>
        </source>
    </evidence>
    <sequence length="272" mass="29792" checksum="A7A2C8942AC11653" modified="2025-10-08" version="1">MILYLNTFHNEKTNDFLYTIKMAALSRKALKYVAVLGTVPAVGIAVGYRMRAVQASENKSEESRVVRACDLPLYQTSKENFQMAEREPYPQNFVEEQIGVVRKAVMSFAGGFQETYESVESIAITGVEHTKSSLDYVQNNPGELPRVIFIALAGMGGIVLGYRGGVVRKFVYSTIAATSTAALCYPTKTMELSDIVTGEIREAWESMAGPASWPFGESKEAPKPESQEREGDSAPSLLASDMAEETPAVQQLKGDPGQSNPNDKDMYSTRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2V9</accession>
    <name>A0ABM1A2V9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 43 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939727.1">
        <property type="nucleotide sequence ID" value="XM_013084273.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860024"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="879"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="963"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012939727.1"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119413" checksum="086E417C46B13542" modified="2025-10-08" version="1">MADISYTSKQMDANCEEDTTITMYRLNSGNDNGSGCVKTCDLFVPCSSGEGVNLGIDSIVVKSELTSSSGTRSRSSTSTGTLCTNSLREDVKKHDIIIVIGRESESVGVDEEHLSVKEEPSFECLCDVKAETNDKLNVESESSLTLRHSVVKDEPICTEEEDVKPVIKPECLTDICTVKTEPLFGHFPDFGDEVRPKVENFVKEEVSEWEGPDFGEVGKTEGQVGDVEDTCAEPVFVEDHMSQAGGLQLKISNVRSLCMEQSASPDTDVVASSSPTSTFSSDPVTSSGSVVRASWDHGESSVYHRSRWQLVRLSHYTASPIVPPTSCSSQDVSTSPHWPLTSGHPVQQTSDMQRRQGQSSSCRFQTGQRVYEENVGSVRKETSSGDIGAVERVCDLHQNIAGDKQMDNRNLYHGREKPHECKVCGEMFSEVGNLQTHEKNHTRDRPHQSEVCGAAFTKSRHLQDHKGTHTRERPYKCEVCGATFTRCRSLQDHKRTHTGEKPYECEVCGATFKQSGHLQSHKRIHTGEKPYKCEVCRATFTQGISLQRHKRTHTGEKPYKCEVCGATFTRGSSLQDHKRIHTGEKPYKCEVCGATFAHGSCLFRHKRTHSTKTHYQCEVCGVTFASSSSLHKHKRIHTREKPYKCEVCGATFTSGNSLHDHKRIHSGEKPYKCEVCGATFTLSSNLQSHKRIHKGEKPKCELSGDIGAVERVCDLHQNIAGDKQMDNRNLYEECDMSLNDCAFASEAKADDIGVESDVCKIVSQTGPGNRLNVSSKHESGGKSRMSCDSKQSMGQGPDFNLSCAKSFASCMNSTESSSTTPPKVYKEMGAGCQVVPRSLVRESRYSGEQPHKCNVCLEMFTELGDLQRHKRTYTIDRPCKCEVCGVTFTCSSSLHKHKRIHSGEKSYKCEVCGATFAYGSDLQRHKRIHSGKKRYQCEVCGVTFASSSNLQKHKRIHRGEKPYKCEVCGATFTQNGNLQSHKRIHTGEKPYKCEVCGATFTFSSNLRNHKRIHTREKLYKCDICGVGFTESGNLQTHKRIHTGEKPYKCEVCGATFTLSSNLQSHERIHTGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A421</accession>
    <name>A0ABM1A421_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ankyrin repeat and MYND domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101845784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940391.1">
        <property type="nucleotide sequence ID" value="XM_013084937.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845784"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052452">
        <property type="entry name" value="Ankyrin-MYND_dom_contain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="391"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="445"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012940391.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="56972" checksum="A9727CE68FA6A391" modified="2025-10-08" version="1">MRSIIVEDCVRAALTWLLVAFEDFTVLSPSPSFVFRAVSMVTSIFSNIPNVLCRCCIELGQFKIELSTLLKMATTEEDKRTPDEKQLFDLIEKGTNEAVIAHVKASKVKIDCLDPKGMTPLQLAAFRGNKDLCEFFLANGADVNSHFHENSYSTLMFAALSGNREITRMMLEAGANVHHTNSVNRTAGQMAAFVGQHQCVSVINNFFPQSEIDYYTKPQGLEKEAKLPASVAPSLCKLINFSNLHPVKITLFLRDHAELLAESKRVCLVLSRLVEKNMKSREVNDVVALKCHFISTVVKLAAEAKENDKEKSITGWLKSLTRGRDGDGFMEFQERLIRQSLKDFPYVSSALLQQLVRQIAPVKIGNDPTAFSLLTSAINGQQFAWDAGEGCETCGEAKAEAKCSKCKMVVYCNQECQRLNWPTHKKQCARLAEQYKIQEEQKKKEEEQKRLEEEKLKEQEAEESQKAASEGDNQGGGDGVEEAKTSEAEVTPEKQEQLDPSQHEACANES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4T3</accession>
    <name>A0ABM1A4T3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HEAT repeat-containing protein 5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940846.1">
        <property type="nucleotide sequence ID" value="XM_013085392.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860112"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1426"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1665"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1426"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1665"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940846.1"/>
        </source>
    </evidence>
    <sequence length="2084" mass="226891" checksum="57B506630A800DB8" modified="2025-10-08" version="1">MELAHSLLLNEEALKRIPESKRPVFVFEWLRFLDKVLAASQKSDIKGSQKRLVEQLTAQITESPGPPTRKLLARCLALIFSVGDTFDLFETINKCNDIIKNKDDSPSYLPSRLAAIACLGAMYEKLGRMTGRTYEDTVQILIKSLKNAESQGRFEIMQTLEKLVCGLGSAGSHTHKDIYKACRQAMTDRAMAVRQAAARCMHELVSEAPFMSTTELETVANLCFRALDGSNYDARCTIAKLLGNLMATAQAPKLPGAKTKPARLEDVLAVLASGFIKGTIGGFLKTSTAGEMIKGSNPVNREIRVGITHAYVEFIKCMGGLWLERNISVFLTHVLELVANPRATPSHVDAVYARKCVQFIMRSVIGGMLGEKAQIAAAKEICQVIVKQMNTVGEAAVEASEGKGQASELTASQHVLVCALHELGCLVLRLGTSASPLVAEPATGIIEPVVSVLIHPSHAARLSASWCLASIAVALPSQLTLLLDRCVERMDKLRSSPEAVAGYSSALAALLGGVYQCALGIPHSKGKQIFSIAEELLRTASQNSRLSLQRTQSGWLLLGALMTLGPSVIKNHLPRMLLLWRNAFPRSVRELESEKVRGEAFTWQVTLEGRAGALGAMYSFLLHCRDLVTEDVIRRMLAPLECALVMMTQLASVIKMYGTQLKASAATIRLRLYDVLSLLPPESFDGLYPNLLRELVAEFTLTDNPANTTTSQLRFMCHADDSVILGSWLQETDHKAIEDQMEPNRKVDKEYLQPNSASGSGTLEHDSQSLYIRCPPSEPIPGPLPLGVAVIDSSVKLYGVIFPHVAHKHRYQMLQHFNECIRQAKGPRQQAVQMNVFTAVLCALKSLAELKSSPGPDDVKKAAFSLIMDAMSSSNPILRCAAGEALGRMAQVVGDSKFIAEMAQHSFDKLKSARDVVSRTGHSLALGCLHRYVGGMGSNQHLNTSVSILLALAQDFNSPVVQVWALHALALIADSGGPMYRSYVEPTLSLVLQLLLSVPPAIVDVHQCLGKCLSALITSIGPELQGNSSAIGTARLYCLVCCAVMQAHPDSLVQAEAIACLQQLHMFAPRHLNLSNLVPHLCENLSSSHLLLRRAAVSCLRQLATREAGDVSSLALSLVVGQGKDSKTNSHIADTGLEGVLFGMLDTETDGQLLSDLRDTIDSLLQCLAIPNLARWLALLKDVLSASTDATNTDNDVDNGGDGDEEEADDIDVTFTAAEPETTHPSVAPRWPTRVFAVECLMKIISSCEEGEGQFDLQLAKELKEKTGKNNFLVLHLSDLIRMSFIAATSDSNQLRLVGLAALEEVIRRFAAVPEPEFPGHVILEQYQAQVGAALRPAFSPDTPSDVTAAACEVCSKWIGSGVARDLNDLRRVHQLLVSSLAKLGSVSGRPRAPLYNESASTMEKLAVIRAWAEVYIVAVDRELESKRKKEGRQNGEEVQPSGPGGWEDGEEHYEQHSGESLLSLVQPELENLSRHWFHALRDHALLSLPSEYSNQLPSEGGAFYHPDTVETAIGHYRKSWPSILHGLAIWLDYTGFDQAGAEPGNEKEEGKLTLGASAIQPANAPANMRARTMNQDRFFLILGISMEALCNSASRLEESTVQHCLRALRALLGTSWPRSQLGKDATLSRELLNVMHRVILTRDGVDIHNMALDVVQRVATAAKEHLDSQRAKQSENTDSKDGVKEGSEATSGEGGSNGDFPSQTSVVFATLEVCLCAIVRHIPALNPSSGSTGFQPPTHLTRMGSATFDLVARVMKLMMELLDLCSPVGAVTVLPTVLHLVTSIMKETCARGAVTPAPSLVQACLDVLTTACKYQVVPDNARDEDGEEMSNVKRDWARLLQSTMASILQYAHPGEDQAGTDLAVLVSMLSVFTTHCPKAVAGIKDLLEPTLDVYRQAWDSDSPANRLKCIQALTSILSHEDKNVPVPYIHCLAPRFIEQLNRPDAPQMLKSPADRELLLAELDCLEQLVAVVEDSRRVTMMALYVPILVSLLLEETTGAQASAEHRALSDRCLERLTELGRLYPDHLRTVMSASAQLKPRLEAAVRLRQKSQAEAKAKAAAKAAPQLNKPTITLKMDFSNFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4Y5</accession>
    <name>A0ABM1A4Y5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sushi domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101854590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940921.1">
        <property type="nucleotide sequence ID" value="XM_013085467.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854590"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="8">
        <location>
            <begin position="597"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="9">
        <location>
            <begin position="758"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012940921.1"/>
        </source>
    </evidence>
    <sequence length="1183" mass="131694" checksum="558AA1E988F23756" modified="2025-10-08" version="1">MRTSFKEGSGDTPSKKKARYSISHVCSSVLIISPVVIRVTLFFERVALGLSLNIDAACKMARPQVSLRLSCLLLLGLWTYVQAEEIDLHLSNPPLFDYGTHTGDIELKDLSSVNDRRLALPFNISYLGSSYKTLYVSKDGLLSFDPSVQYLRNARWQEGSISKAYDKPFLAPFYFDGYEPIVDDYIGEVLFRLIDKNKLDGDEHESEYRRLLRYMNEYVPSAVVNPPENFDAQLIVVVTWVDVTDSAQKEEELDGGEYCGPTSEPCKSATFQAVIVADSVNTFAIFNYAKMDIPITGNYQAGFNGGYRRGWYNVIPCQEECLANLNASNVNDLPSHTGSDVMGRYILSVGHEVIIRGGCLPPELVAGTLEVYPREVGMFGGELLEVSGKCAGNSNPVHCRFSYDDPSAPVKLYVQTEGQMRNGMKGFCPVPRMTWTGPTVVSWSSDGVEWSTHRSITVVLPDRMERPVPVPDAIEKQWYSQDSETITVVWDPDNFSPRGSQAEVEITLLGYMEDEQSGTVRFSTLESFGRADNSAGQFTFTVSDHRCKKDCEKFEQALLEVSLPPELYAQAKERVALRYGPIPLGWYVNEELTKVRGGDWSNQKCHEWHSKDSADEKWVEEIIPCPCSLDQALADFGRFQPDPGCNLYTGSACYFHIGAKHCVRSVVPSKAGAGNQCCYNHDGTLRYSQLSYQGSTPDRGHVWGAHPFGRPDHVPSLSHWKNDVIPLYYCCLWNDYQLCDLYMEQRPTADCRNYDVPGIAFLRGDPHVTTFDGLAYHFGGKGDFWLVRGPGFQMQGRFGDDFAAAPKQNVGSTALKMLAIRVPGAPEILVWPAPERAITYRGLDILVENERRFFYSKSTMWQDFQGGVSVVNNAADTSYNRHDNFTILINDVGVNVVAAHGLLHIVVALPPSMKPANQNGQKTAGLLGAYDGKSLDDFTSKEGTVTAVGEQNRNIYENFALSWKVEDAETLFKYPKSAWPLSSYTPYYEYSEIPNNYNGAPQEGTIAGTCQTNDRCRWDYRVTGNRAIAQDTRDADKRFDFVSASAYKVENCGLPDVGLMAVMDSHNFSVGREVKVTGCENGKYFSGEATYSCVRERLDTATELERADYGIKVVDEDDNVEYIIHWLPRPGHVCTIDDPAADIGIIVAIAVGTGPPPVYRPSGDPVRMSGSSKEERGLQGSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5X4</accession>
    <name>A0ABM1A5X4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin-like protein KIF25 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941449.1">
        <property type="nucleotide sequence ID" value="XM_013085995.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846443"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF63">
        <property type="entry name" value="KINESIN FAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="178"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="269"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012941449.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="66170" checksum="1AA51889915E647C" modified="2025-10-08" version="1">MHHDKHFLKDLNNHTSLQCIAKKILLRFQRKDERIASLETENAMLYLKLANLRGEVSSAKEEASASNAVLETGDRFKMNVKQRAGQLCLEAQNLKSELSKIRALALDMPHQIGQFLQRAKTVVQHHSAEFQSHSSNITALADQVCQLQNTLSDITDQHAREKRRRQELHNLLMELRGNIRVHGRLRPLMEFDGENEDVSTLGRPGTKSEVVVHYVDDENVCVRTSKHNKVFEYERVYSPSEKQESVFDEVQPMLTSLLDGYNICIMAYGQTGSGKTHTMLGSHRNDDYNPSQDPHPDEGVIPRATRELFRLIEEKAPGTHSIEVSVVEVYNNDIRDLLSSDPNAKHDVITGGDGQLSIPTVISKPVDTVYAVMCLVQRGLRTRRETATLVHEHSSRSHLIVTLTVTSKAPSFFAKSASVDSNLSEVGLGKKGRSLSQTWTNDQLQGIGQGQVPANQQPVIRTKLQLVDLAGSECVGMSGVKGVALREASFINKSLSALADVLGALAEHRTHVPYRNSRLTHFLQDSIGGDAKLLVLLCVSPAQRYITESLQCLGFGQRARQVQRGPTKRRLPSSVEKVTAADGQSSSRMRSGSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6P9</accession>
    <name>A0ABM1A6P9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Gamma-aminobutyric acid receptor subunit beta isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101859661</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941886.2">
        <property type="nucleotide sequence ID" value="XM_013086432.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859661"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19006">
        <property type="entry name" value="LGIC_ECD_GABAAR_LCCH3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002289">
        <property type="entry name" value="GABAAb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01160">
        <property type="entry name" value="GABAARBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="54"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="275"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_012941886.2"/>
        </source>
    </evidence>
    <sequence length="525" mass="60005" checksum="C5A9412A206D0983" modified="2025-10-08" version="1">MRSPSVTMSYQKGGRAAGAMWSITVPCIAFFFFCSNFVVSRCQQSAEHFGNVTQTIEGLLKGYDIRLRPSFGGEPLEIGIEVILASFDSISEVDMDYTITMYLNQYWRDERLQFLDNDTLDNLDNNTIKAMTLTGAFAEKIWVPDTFLANDKNSFLHDITEKNKMVRLYGNGSLVYGMRFTTTLACMMDLHNYPLDHQQCTVEIESYGYTMDDIVLYWLNDRGAVTGVEDVSLPQFSIDTYETINKIEELLTGDYQRLSLIFQLQRNIGYFIFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISNGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGARAKRKAKRLRERATSVRRTRVEEPPEPMVNLNNSNLEAVELKEVHRMAPAPMGITNSQSFNLELDDGSIETSGFRMAPTIPRPYTSHAPTTAHGYIPSTVVRRRSSSHVPPRRRRLLSNFRQKAKSIKVKIPRVQDVNTIDKYARLMFPLLFIIFNASYWAVYLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6Q9</accession>
    <name>A0ABM1A6Q9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012710</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941907.1">
        <property type="nucleotide sequence ID" value="XM_013086453.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012710"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012941907.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22487" checksum="1BA29693C32FF09E" modified="2025-10-08" version="1">MSELLPSSPLQKDWLELPRQLYVAISSAEDVQKKTSDLDLFKTGDAQRKVLGHIPTNVQKLSGGALLVNGATESEVTRLLNTMTFGGVPCTSARYQKLNCSKGVVCSHELKDCCRIEEIVANCEGVTHARGITLRRGKITLEINTIILTFDSCRSPATVRPSYLVFGVRPYVPNPLRCFKCQKFGHSQSRCRNAASLWQDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A810</accession>
    <name>A0ABM1A810_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylyl cyclase-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942603.1">
        <property type="nucleotide sequence ID" value="XM_013087149.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850432"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028417">
        <property type="entry name" value="CAP_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01089">
        <property type="entry name" value="CAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="3">
        <location>
            <begin position="36"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942603.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21253" checksum="871F0BE6738EDC50" modified="2025-10-08" version="1">MKTHKNPALRKGPAPFKAGGGSPKPAPSPKPAAAAPAKPPLTELQGKKWVVEYHKNNREIVLDQTELRQSVYVYRCEGCTIQVKGKINSIILDSCKKTAIVFDELVACLEFVNCQSMQAQVNRTVPTVSIDKTDGCQIFLSEKSLDTEIVSAKSSEMNIMVPQGSGDIKEFALPEQFKTVYNGKQMVTQPSDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAH8</accession>
    <name>A0ABM1AAH8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013275</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943984.1">
        <property type="nucleotide sequence ID" value="XM_013088530.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013275"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943984.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17841" checksum="163AD102EF69146D" modified="2025-10-08" version="1">MRRQSLASPELTAMLERQRTHSVERQRAASADSRRPTLKVDRRAAPRFNLLKDHQQTLLDKKRGVCEEKEDQVQKVSADLPQCFLQRVHRCVQAGSSSCVIASLLKSHVSSRLHTDRAKRVLDAVKDKTDFFCLLQLCNYDKEALTCALWYGVLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABH0</accession>
    <name>A0ABM1ABH0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944503.2">
        <property type="nucleotide sequence ID" value="XM_013089049.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854907"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="77"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012944503.2"/>
        </source>
    </evidence>
    <sequence length="500" mass="55636" checksum="EEA517310220F022" modified="2025-10-08" version="1">MGTEEILLTIGNEGRFQILMIAWSSLFFSCPGWSNSAITFLLEAPNWCCPEQPRGNWTEDAHHRYSNHSLNSCVDTSNVTSGTAIRTYGMMCHVVHNGRQEDCTERVFDGSVNSIVTEWDLVCDRKWQASTAISVQMLGLMLGALFAGNISDAYGRRLSALVAHSAFFLATIACMFSVSITMYTVSGFFSGMMYGAVNTISLPFTIEFLSTSWRAVPTAVPVISSLRLIQCVQWYILPEWRSLYLVSTMFSLPVFFTFIFVPESLRWLAVKGRVVEAQKLIRKIAWWNRTTHTIPEDCFKKELDEVFSKAKAQEKPKGAVCNRVFRFTEVYKTWGLARLTITLQLLWIAVGIVINGLTFRLSELSGDVSINLAITSFLDCACSLVSRVFANRLGRKWSMVTLSFVNCVLALVSLFCVLFAVALNGASGYLITASCLIIKALCSLVNIMLLLYASEVYPTSVRTLGFGWCYCFSRVGGILAPFVIDLVSSLTSSCYSDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABQ1</accession>
    <name>A0ABM1ABQ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013436</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944652.1">
        <property type="nucleotide sequence ID" value="XM_013089198.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013436"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="946"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944652.1"/>
        </source>
    </evidence>
    <sequence length="1319" mass="146793" checksum="6288BCD7B5B63F92" modified="2025-10-08" version="1">MSETCGDVTQSKPTPPTTGSADRRESGGKDTESASDEENCPSDVFRKCEEHLSRISTCTGLQQTIHDEIKKQAKFDSIVYHKMASKSRRLLHHANCLEQAGTSGWMCQAIVELSGQVMRQAEAHRQLVSTLSRQCKTIQHAIDGHHHLLSSVHTKTDPSSGDKPLPTERDVIAHVGDSRNRQERVNLSFREACEWFENIRTSRRALINKMEYLKAQQQKTDEQICQTRSTSQNLRTTCDQNTLPWSMQLKIQDCESRADFLASRKEQVVTDLTSTSQELQQFDLDVEPTLLLLVRVFELHQDSHDSSLRNGFHLLKAVSLRDRHLLEQFQQHPTHAAIALDGEEICDVAKVSRENNVLSPFQERLQGFTRISEPTSSKANYFEQKSNVSNTRDVKDTLLHSSSNVCLTEKTENIPVGAGSERDSKGLQVSNETPVATELGCHQRNKATMTAELGYHDSDKATELGYHQSDHQSDKAIELDYHPRDKATMTTELGCHQSDKATMTTELGYHKPKDDLSPATLGEGGGDSSMCKTTTSQPERQTVDLEQNSDVESVKSDSPCHRSVASESSGCRDSNINHFHYVELPHDLNPGSSVRPTPRRSSMSTNLCDRNGVNKCVDVLDYCHEESLQASQDIVEMYEGKPTEQTRIISRKKSKAFADQNSGINSLVGMSCYRNIEGEVLESVDTNQAAHIENEASLSLTLKSGEEFPREKSDSNTTESLQTEALIAKYADSSVTGRQKHIPYKSEFLMNESRTASVNKEPRPRDPLASFDDMDERGRCSSQWVCGLPAMSSEHSQEYDEMRTSSLLGKYMWSHRKSPYLSKNFNNSEFDSSNAATVALPENGDTLEFEQYHKSPSQKWSRQKVKVCAVKPLTPGLDTYSWSTESDGDKASCSKGSNTDEDACVVTAESQCKPWGKDTNSQEQLNSEKTEPKQLLIQIKNTKDSTSSIGYTCSEHERRNGEDTGSINQSAVEEGLLCPLSSHCATINTLLDTSPDLPRIVSSAEYPQTVSFPEYPQTVNSPEHLQSGNTPEYLQTGSSSAPSQSGCSVEHQQGGSSLEHLRSGSSLRSLQNGSASEHLQAMNSWDYNQTGSSLECLAKTGSSLEHPKSGSFPEYPQSGNSAGCSHSVYDEEDPTYKYRAMCVNGIKQTQRRGIVVNSINFENALPRNHANGVVYGSPISQSSLKLEKEVDNSLVSGIFIPQFQKLRSPFGQWLWGREDTIDRLARINAYVDYYDYEPMPNIGTGIRAEGYSPLLSSRWSQVHSTPLSTSCSFLDACYYRSGRFDGIEHEQGEGADGGQRSKKRQKKVRFSNVVSYDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD07</accession>
    <name>A0ABM1AD07_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized serine-rich protein C215.13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945361.1">
        <property type="nucleotide sequence ID" value="XM_013089907.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862230"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945361.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="63099" checksum="11B42D7EBB6D2FE7" modified="2025-10-08" version="1">MSTSEEDDSDPRGPGSLAGDTSHEDGRTRRKPEGSKVAQHASLWENPGSASQTSSSVSRHRTNIPARHMSDLSAKINATRQKFNQAQDGTSSSSSSKPKSDTAGEPVSKLLHRGRTDFSQLLQKFSGSEASASEKSDCENVGLTSSSPVSGIPRRGFVRRQEAKEIISSSDDSESARRTPERTQSLKLTSNRIREDGNRSSESPGRTGIEKSSSFRSDFMSRRLSQRRDEGSDKESTEPAKQTSAEATVKTVASPTSNKPSASESGTLSGVTSEPAHPEKTSSPPTDLTDGAGTWLSGRGSQEAISKAEDYIKRVETTISTARSKRSAEKSKSPSLGIGSTSASGRTGATKSSDDTKLRAEEERAGSFINPTEKPVVDESSASDQAISGTGDAKSESEEKSTTAAATTAAASSSHLPSSQSASHVPDTLSAVSSSSSSSIKPDTLSLPSVTTTSAEERVPSPVSSTSSISPRPGEAASSDHSFTSSSSSSSSTISSTIRRSASLRDNSFRSDSVDKQRKGILKRTSSMSKSDGGSSDVIVDPQLAKILQQRREIQGDVEEEDEEVEEEEEEAACVSPRRRRSRALSAAEEIEETLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AET8</accession>
    <name>A0ABM1AET8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101848095</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101848095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946323.2">
        <property type="nucleotide sequence ID" value="XM_013090869.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848095"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012946323.2"/>
        </source>
    </evidence>
    <sequence length="422" mass="47020" checksum="80935D4BF532A34D" modified="2025-10-08" version="1">MSYLWHTVSAFMGSVHGLATEMFFKLVQHRSQGSGSWKGHGGQGAGHNDGSDFLLLLKHLVLQLSSCEGNARPWLASCLADSSTSAQLSSSLRLAMGLPAHLLFCNSIHEMVRDHHGQHFLSNLRCFSKSNLNTGGCLSLDATVFVLQGFSCMTERFEPELCEMLLSDPMVTTSVLVHKATLESVNLLRNLPMDWMDQCLQAFVWAQRTVTGENVPECCEKVSPYMKAAAVFALCPDRRSDEKLVPNLQALDPQVLDFVLELTMCRITWNVDSCSLQDTADMTLVAGLLSLRPESLCSLLTHGAHEWTTRVRHSLGLACSGQHRRLRDYLLLRTLEKLALTDLCRRGSQVPSCVLSAYCQLLGHYFEDTDFVSQVVSDDLLTLAKLMSGLVEVSSGEHLRQMDLTLLRHTDPVLYRKVLHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEV9</accession>
    <name>A0ABM1AEV9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Eyes absent homolog</fullName>
            <ecNumber evidence="13">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101857384</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the HAD-like hydrolase superfamily. EYA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="13"/>
    <dbReference type="RefSeq" id="XP_012946346.1">
        <property type="nucleotide sequence ID" value="XM_013090892.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857384"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02601">
        <property type="entry name" value="HAD_Eya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028472">
        <property type="entry name" value="EYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006545">
        <property type="entry name" value="EYA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042577">
        <property type="entry name" value="EYA_dom_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038102">
        <property type="entry name" value="EYA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01658">
        <property type="entry name" value="EYA-cons_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190:SF16">
        <property type="entry name" value="DEVELOPMENTAL PROTEIN EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190">
        <property type="entry name" value="EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 13" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="138"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012946346.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="53229" checksum="8EB1B0F4258AFF02" modified="2025-10-08" version="1">MSVYMGHGQNAGSFMQASYPYHQGSQSPYSMLQTQYGTDALAAKIKGPSANPVVAPGYMTGYSQIPPSAQSYYPAAAGGLSYGSANSVPTYDNAFYSYGTSGSEYYQYPYLSSSSAMTPPTTVPSTQTYQLIDTPTSVANTAGMEPGQRPPSFPCAVPPKDGLRDSCAEAQGEGSYNQMANPSPPLKENGQRGSRPRSGRRTQPSPGPESDLERVFVWDLDETIIIFHSLLTGSYAQRYTKDPQGSMSLGLRMEEIIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSNYNFATDGFHAAANNANLCLATGVRGGVDWMRKLAFRYRRMKEIYNSYRNNVGGLLGPQKREQWIQLRQEIETLTDSWLTLALKSLQIINSRSNCVNVLVTTTQLVPALAKVLLYGLGGVFNIENIYSATKIGKESCFERIVSRFGRKCTYVVVGDGRDEESASKQMNWPFWRISNHSDLAALHHALDLSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEW7</accession>
    <name>A0ABM1AEW7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106013957</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106013957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946358.1">
        <property type="nucleotide sequence ID" value="XM_013090904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013957"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012946358.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12589" checksum="69ED17870BC0F882" modified="2025-10-08" version="1">MTTIRSSVRPESSKQPWGTILKPEFGLGYQKMTDYEIDQTVQRLNTVPVPKERAYTRPNKKMSAEEIEAMLERLTKAEKEKIPDSDRRIVASIYKDMGVVSSYAWQGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFR7</accession>
    <name>A0ABM1AFR7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101851101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946777.1">
        <property type="nucleotide sequence ID" value="XM_013091323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851101"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1449"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1456"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1552"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946777.1"/>
        </source>
    </evidence>
    <sequence length="1615" mass="176217" checksum="EBBC578A9E7E996B" modified="2025-10-08" version="1">MESFFDAEGLKAGEELGNDYCDRRLTFSHQNQGNPTDLSFGLSSIISNTSSGGHTSSGYADSSFADERDELTPTGRQNIPDTCVVKRSKTSILRQKLRLTRVSSRNRSANSIGLGSKPRFRASLVTSDQVCRTGYAQKSSHAHRSPPRCTTDEECVDFYIEKYLPFQHSQQKCRSSIRKPKVDNFISGKENVKGYKSDKRTRGRDQIEVCSELETEKAKYKRRPLSASECRKVGKAKHVGRREARGDYQDGKSRRRRWRADHVSDEYLAKLDACLVSKPCQMNRKNRSWSEPRCSSTSKTFKAIIDEVVSCQGASSQFVNKLWGRGKHDGIAVESSLVGHKESKTRAMHPAAYKKRSKSTSVRRETLLTNSRDCSSEPCPRPTIVPLSGVSAHSRQRARRRYKRSEFRYPPRRGVRLCKTPTVADFELPTPTIASLLRSQLCQMSQPASRNGQSARGTVTVGKTSARGRRQQKGQEQTQRGSLTDRMDMPGRGAGRNSDFVNSSGGSNKAKANPSRELVNHVYILKSLPEDITPSETETVMKSVKSICQKRICSADRCTRPFAFHRSFNRRHRSNQTVKPGWEHDVTSEPNLGSTSRPGRAITPVDRSRKESNRRGCARLKSKSPTESDRNCHSRKAGVQSSTSCCTDRGVPAVRKFGVEGEPRPAKENTEHMAGAEMRCKQGGCSCRSWNKHSVKQSDQKTSVGIQHVEVLEKKITSNEPPDDSLTSMKDVSLQTSLVSTNNVEGGKTWSLSPSQIMHESGVSVSNSSHPVTIPGGQSPVNGRGCSERKNAVSDRAGIESKDKCVWKNGNTFLTSAAYGTPRAVRAVRAAQRTQTHEGGLGETPQYKGWQVAGSGNGVAASSGHWCPLDQTHAAISVRTPPGVVGSAFLPPCPHEKAEDVISVNLNDERHEILQILSDSSSGGTYNVQTSLKDRDKTRTNNPTVRDKSDPVMAVTVPGVPVDNSARGGAGTCAGGADVSSDWFSSLHTEVNLGDLSGLSTGTAHTDTSVTLRLADLRPLTELDSSFSNASTADSAVRECSIGERIVQTADDRARRELKCPCAPCSRVGEDRSDGLTGRTTVHADVLVGLTSVSSTNLETIDGRTMRTNCSENAVHCNILKSSNVSPFFGTLDFESTPKADKNSIHGEKKKNHSVFQGKYFHERTGKPNVPNVPQVWKEHNSEMKCSKKVSSSWETGKGWSPSLSSRLDEDTATDGLSRATSKFSTRTCLSENRQTSCGSQSSAHVSVCLTGQGTSVSHKTVHDKAIMLLHSLSPLHPADVNTVYSIPNTTQNETSSATSNSQSSRRCSTTENCNVQAQSLSRSNHENPTPRVENTAGSNNSREGKPEVTELKKSGSNNLDKANRPSPQFNVTKAHRNICPDSAVTAAGSPSGSSRHIRPSLGLTTDDKFSVEGGVSPLPHQRPVVMKTYASTSDTPVQVELLKPWQASDGEKTSPHSGPQRLQSGRSTRRRSHGNSGHCCFTKGGGEPKSGQLSSGPGGGGRGSHRPTGCFVDGARTRKSSTQFPPLYKSWPSVTSDEDSKDACEWDNSDDNSSNNNNNNNNNNNNNNSLNDSKINNSYGSNNSDDKNKNNDDYRNFKYNSCQPNNENNSGTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFV1</accession>
    <name>A0ABM1AFV1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Toll-like receptor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101858387</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946829.1">
        <property type="nucleotide sequence ID" value="XM_013091375.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858387"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="771"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012946829.1"/>
        </source>
    </evidence>
    <sequence length="911" mass="104205" checksum="D5AB245D8CFC62A1" modified="2025-10-08" version="1">MTTTCVRVCGKINCVHHAVAFCVCSYSIWVLLMLTNVAVYYIIAAETAPAWVNRDTCDNAWVRVRSPCSEHMGQTGPHVNCSGKHLKEINAAWFPCNVSRLSLDGNSLVILKNTSFLRLYQLLWLNLRGCKIKKIEPSTFDSLISLEYLDLEDNQLEFSKAYFPSHLFAPLTELKTLRLARQDSKPSLLFPKDLFSDLRSLLGISISNMGTGILQFGPQFCQLSNLSRLEITGSVTQITNSSFDNLACLTLMELSLYGLQHLKKFDVDSLRHFNNSLRSLHLERVYIGVQNALGILKPFRGRNMYEIYFNNIGLSSTHSDGAITTGDGIVDSDSVIYLKDICVERLTLQKSHIFVLKRSALPVGLLWRCLKHLDISFNDLQLSTGIYRILQMPRLETLVIVERHRENTLTDEDRKIIARQTPLVSFIPPDTRSQTNSRERVQLGPRRMSCRLKYPSDIRRRGRRQVTRTFYTSGSLRAIIVSLSCTRSNHFGGKYVYHVHCENMKTLVCRYCGLNDMTGEVTGLEHVQRLDVSHNDFAFISPSFLEKFTGVEALTLSYTNLDSDFMSRESEVFFSPLDNLKSLDLTSNSLTMLSKGTFRGNEKLESLFLGHNKFHQIPFDISFTPRLKHLDLGYNAILQLSERQRQQLDAHVLKVPEFRMVFQGNMVSCSCGAMAFLRWLQKTTVVLDNNGNYTCVTERGHLSSISAFRDIHGMWRWCYSGYFYWISLLLVAGMLIVFLMAALVLRHGNYFRAAILRLLDNKFKMKSRADYQICVFIGYAEKDYRFPCLRLLPYLESLGMTVYVRDRDSLPCQDVPSSIMDAMQSSWRIVLVVSKAFLTDDQWSEFTMRSAVYCQSPSNPARVVLLVEERNRNRLPLLLLGAVADDNIVCLGRLLMCYELRQRLQVLLKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VNQ8</accession>
    <name>A0ABM1VNQ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118477218</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118477218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824050.1">
        <property type="nucleotide sequence ID" value="XM_035968157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477218"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme NO-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824050.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="32918" checksum="7DE40E0889687312" modified="2025-10-08" version="1">MVPDGLINSDSFARRCDTEEDGSLKLHYHSSRSGYHPLVKGLVCAVAREIFNQTIEMTLISRSREEVDDGRDQEHAIFHVTIKDHQPMVSPQSQGTTIMSKTTSPQSKETTCCGAERKDISSPESEKQDILQKSSTNMINRNKSGSTSNNANGPQPSSSSSSTRPPVCPMSAICNPQTTQLFPYPEPVKNLNEYKVNSTSSRADLQHRDVHSKDRTAADSQNVDTNGIDSDFKQRQSVVSNGEDIEFEQRNGVCSDDFALADSELLAAKVEPHDTLNTSKQIIPVTSQNGVDTEVADMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSX6</accession>
    <name>A0ABM1VSX6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen alpha-1(I) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825518.1">
        <property type="nucleotide sequence ID" value="XM_035969625.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477645"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040010">
        <property type="entry name" value="ZN608/ZN609"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21564">
        <property type="entry name" value="BRAKELESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21564:SF5">
        <property type="entry name" value="SCRIBBLER, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825518.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="36773" checksum="B068AC726AB7BF81" modified="2025-10-08" version="1">MISSGPSRPHDMKSGDLIPLDSIKKEIVHSKDGSRPDSRISVGGPDVKRYDVKEEIGSRPPSSLDMNSKSRPPSQSNTANIPGGGGAPSSSSSSSLPSSSSASLLSSQSLPTTHPAAVINSLTPPTPISGAGFPYASYYPPHPMYRALNHHIIGYAGAPPGPYIHPSQIGYRMPGPVDVDGKVTPSDATAAGVGGKSGGPPGGLLDPVDSVKGGAAGGAGVIASPSDVSGGVLVGSGVPSSSGGLGAPPVHKIHELQEKGRPSPGIRSPTPSKSGSGGGGGAGETGSGSGSGGPPTPGSADKIKEKQREYTNSPPTQRHVHTHHHTHVVGGFPTLYPPEAYSAMFSHPAAAAAAAATLQPGAHPFPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTL2</accession>
    <name>A0ABM1VTL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011803</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825754.1">
        <property type="nucleotide sequence ID" value="XM_035969861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011803"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035825754.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27459" checksum="D6E6591793B401DC" modified="2025-10-08" version="1">MTTFESKADVCSLLQNISIDFVGDSLVRQIYISFLSKLQHQSLNKAETSNTSISHRKRCQEQLIYQGSYQYYIVRSVTDCNQTVNLRFHNHHKLTKPGEEEINRTITGLVGKQYSILYIGLGLHEDLNFEFVHERVVKPMVKIVGKNQWPKIIWATPHSPGPLKTPTFTKQQKDSVIAFNKKMHKVLKGYNIPVLDTFPLTTDIISYDGVHYGKRINDIKAQVLLNLIQRLRNSGWSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUG5</accession>
    <name>A0ABM1VUG5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane channel-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826057.1">
        <property type="nucleotide sequence ID" value="XM_035970164.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011966"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF40">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826057.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="52708" checksum="DFB83F3E222A1556" modified="2025-10-08" version="1">MSENKLRRRGSSRSSRRRRRRRSTHSMTSSYGGMDEDDEMLKMFDNDEDEDDIEINNNHNDDEGDDDENNGDGEKDRIAEELDARRRKLEEALKEEMLLQKIEQCKSLIESVKQQKWKMSRKMKVLSKARSYVEKHEGKLSRSKGYQQRGKQLMKQAMRWWNNVMASLVPWEMRIKRIESHFGSVVASYFIFLRWLLWISVWLAVIPSCFIMIPEMVLGSAHGTTNRKTIPADKEKTAYDLKTIWNAEGVVEYSLLFYGYYGNDGIIGQGYRMPLAYLLTSLTTFAFSFIVVLKRMANNSRQSRLSNKDEQFTFSWKLLTEWDFMIANQETATTKHASITTTFKETILEEQEKAREGKVWLLRSLRVAANVIILLLLALSTYVIQLFVERSREMELKVRNDPNYEAGFWAENELTVIMTLISTIFPNILDLISLMEKYHPRTSLRLMLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUU0</accession>
    <name>A0ABM1VUU0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826182.1">
        <property type="nucleotide sequence ID" value="XM_035970289.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012035"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826182.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24275" checksum="106129A15EEB0E07" modified="2025-10-08" version="1">MVLFPGWELGCTVSGQTLFYCTVSGQTCQTLFYCTVSGQTLFYCTVSGQTCQTLFYCTVSGQTLFYCTVSGQTLFYCTVSGQTLFYCTVSGQTLFYCTVSGQTCQTLFYCTVSGQTCQTLFYCTVSGQTCQTLFYCTVSGQTLFYCTRHTDTGVPTASRWERLAGDKELNQLRHKGEKSDSRSTRADSVGSRHLEGEVPSDKGLIICYGHFLLPVKTCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVC3</accession>
    <name>A0ABM1VVC3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sialin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC118477885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826365.1">
        <property type="nucleotide sequence ID" value="XM_035970472.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477885"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826365.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13912" checksum="9C2EBA2C2A3FBF8A" modified="2025-10-08" version="1">MDMSSQPVVEISPLFCSQRLTLAMMVFLGNCVSYFARVNMSVAILCMVRSDVTVLNGSLSNVTNVASHTVDSCGGPDQALTADLLRDDTGEFSWDKGTQSKLLAMYFYGYIFTQVPANAALLPAPVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVE1</accession>
    <name>A0ABM1VVE1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101846512</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101846512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826383.1">
        <property type="nucleotide sequence ID" value="XM_035970490.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846512"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047276957" evidence="3">
        <location>
            <begin position="21"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="748"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="109"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035826383.1"/>
        </source>
    </evidence>
    <sequence length="938" mass="103634" checksum="B09D85711F02B2A6" modified="2025-10-08" version="1">MHQFFTTSLTFLTLSALASGSRPYLPPELENSVKKLIQTGMNKPRIIESLAHIARRKLMTFSGDAGGTDSRVNQTEGGGNLNHVGSDTGGDYFYYLDNSDYELPPDDRSFTCMVDILSYEEGLRSGHTWALSMVDATGSPGPGLLRHQFHWLGQYSECKEVKATITTQSNSSESSGSDHRDVMFTGRSCLVIHVPSVDGVPRVGEGRESMWEVCMPSSCDGPALVDLFNEVLASFNLSSYLTVVYSVCGSDGGDDGQLMEESIPPVVFVLVLPIVAVIVATLMDFLLDPSGKLQKKRVDTASNKVSGTPSSSAKENPSSSIKEHPSNNAKENHSNNSTQDIAVLPLSYMRKGEQLSVSEENKDTDQEVPSMNTNKVDIAKVGPSTNKDKIESSTNTGKVDIASVVQSKNADKIDIVEVEVSNSEGKSSDTLDEEVSASKDTSDIKQVGPSASAKSDEESGTAAMNDLSSPKTSSKQQTTLMTSESERGTCETGIRARRDNLFLRLLLCWSLRPNVRSLLATTHSQGSLQCVHGIRVLSCVWVMLGHASLLLLVGHGLQEFMYQQRQVLAYQIVNNFTLSVDSFFVLGGLLVAFNLLEELEKRGGKKNWFFFVLHRYLRITPLYMAALVMDTFVAPHLTDGPLRTAINENACRFTWWANLFYVNNLAPNLNGCMGWCWYLATDMQCYLLSPLIIVPLFRRPVLGYIIAAFFFVATSVIPFVLTVVYRYGTDVTFVEGHTEPLNKFRDNLYYFPVFSRMGPYVVGIMLGFLLFKQKGKQQTIPRVVNACGWAVATALALAVLYGQHSYVKRGYKEGINLYLAGAYNGLARSTWGICLAWLIYNCHHGYGGPVNKFLSWRAWLPLGRLSFCVYVMHVVVLKTDAASAQSLPFVSTSYFISIFSTMTLVTFLLSAGMYVCYELPIPNMERVLLRRFAKNAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVG1</accession>
    <name>A0ABM1VVG1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Complement C1q-like protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101851650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826403.1">
        <property type="nucleotide sequence ID" value="XM_035970510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851650"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045546345" evidence="4">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="103"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826403.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25455" checksum="A9B0716CC1DE9BB1" modified="2025-10-08" version="1">MASRQNVILLIILVVSFAMTSSKRSPRRNRNRGQYRDSEIEDDQSGDLQDVCELEVSCKGGEMLPVSLPIRGPRGPSGKPGTPGLPGKRGPPGVPGEAVLNSDDAGHVAFFVGLGSNTGPVSSNTDLLFDKIVTNVGAAFSVETSRFTAPYNGTYSFSVTIAAQGRQRAAVEIVLNGKMVATIWAESFPYWASASNTVILNMETDDQVWLVLLSRASYLHGYMYTTFSGHCLYRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVU7</accession>
    <name>A0ABM1VVU7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multicystatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826539.1">
        <property type="nucleotide sequence ID" value="XM_035970646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857420"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186:SF2">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047005749" evidence="4">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="5">
        <location>
            <begin position="125"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826539.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25869" checksum="E598437474B9DFBA" modified="2025-10-08" version="1">MFVVLLIATVLPFACQAGLAGGKHDIPLSEIKTDAPEILFAVTSINGFYAKQGDNDQRTLVKVVKAQSQVVAGVLYDYTLDVKSNGGEELCEVSVWSRPWLTGDEAMQVSKGPSCKQVQQDTSKLILGGEQLADPQSTEIQNALSFAVDQMNAQENYLYLRKAQTMDKVTSQVVSGFMYHFRGVQMAATDCPKGSNQSLDTCNVSSPGNVRVCDFDVWWQSWMTPEYKLSKMSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWV7</accession>
    <name>A0ABM1VWV7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478066</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826899.1">
        <property type="nucleotide sequence ID" value="XM_035971006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478066"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826899.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="44701" checksum="A669506D356C8507" modified="2025-10-08" version="1">MVFNVSAESGLPSLLDPATATKPAKVTIAEANNNFVNDIHAAVDSAIERDAIKEPREIQIYAESLTTTTSSPDILSGGSLSNSSDSASKLSNILREMAASGKTVVQREVFVSKAAIESMLNNIVEGTAINVAALEPDPDQLGTQTGFSNNEIEFMTDLLAKRRRYQVHTKLDMASDITSNCRETWDSLQGLNRDFLGYNGTIQVKTTAYHMELQRTTRQDILTGGARDRQNSVFAVSDVAADDVADIHTQSTVTKNIFINGQHSKHITTDVVIASVADKAGTKLPMTSPRIFHQVADDCATESSRLSFVTPEFVAEDAAKLFYHSFDYIDPNGQVCVKVRPTDHSVFYRLYLQVGNFPTDINYQYRYVVLTSSTNIRRKEEEEEEEEREEVEKEDEGDGFAVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWZ5</accession>
    <name>A0ABM1VWZ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhodopsin kinase GRK1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118478098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826937.1">
        <property type="nucleotide sequence ID" value="XM_035971044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478098"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826937.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17804" checksum="CEBA69C4A2E54D02" modified="2025-10-08" version="1">MKWRDLETQNNQAAVSLRSLHKKNIYHQNLRPENILLNPRDVAFISDFGAACLLSEGCDKVDTWTAAPGFRGPEADKEDGQLCPFQLDTYSLAVSMWQVLSGLCPVKNKPLDHLDNIPPQYAALLRNLLLPDPDMRWTLDKFLTEALELHPDLSCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXD9</accession>
    <name>A0ABM1VXD9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Helicase SKI2W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC101857502</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005103863.1">
        <property type="nucleotide sequence ID" value="XM_005103806.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827082.1">
        <property type="nucleotide sequence ID" value="XM_035971189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857502"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="337"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="607"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="234"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005103863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035827082.1"/>
        </source>
    </evidence>
    <sequence length="1258" mass="142062" checksum="8E222F29D1649ACF" modified="2025-10-08" version="1">MDTHFDLVETGCCSHLELVPQQIGPDKSSKRLTFPGVTLPVGLPPVLPSLEKEIEKFLIDPESLPIHDLSLSQRLIPREPRYERLYHVDTCPLKTTIQVERHPTTGKLLGFTEELIPDSAETSRNSLSLRRAPDVGSTRSKQDVRGSNINLPFWPGGLDTTADQLLEEVTETELKPSVLDLDNADQYLTTPPGFQSGLHLASSATSESATVPSNSADTPTVINLADIMAVDDNLDLGDSDEEKDEDGKVDGDLDTKETISAELTRSESLENLVQPSDQAPPKTQSEEQPVKKKAAPPKEEWAVKVDISSPVHDFYKRIPNMAYKWPFEPDIFQKQAILRLESHDSVFVAAHTSAGKTVVAEYAIALSLKHMTRTIYTSPIKALSNQKFRDFKQTFGDVGLVTGDVQLNQTAACLIMTTEILRSMLYNGSDVIRDLEWVIFDEVHYINDSERGVVWEEVLIMLPQHVNVILLSATVPNTMEFADWVGRTKRKKMYVVSTAKRPVPLEHFLYTGNSTKTCNELFLLLDAKGSFQTSGYNKAMEAKKERASKNSQGFGAKGTRQGNPMQDKNTWLSVIEMLKRKDKLPAVAFTFSKKKIEETASSLQSVDLTTASEKSEIHVFFRRCITRLKGSDQTLPQVLQLEDLLRRGLGIHHSGVLPILKEVVEMLFQKGLLKILFATETFAMGVNMPARTVIFDSIRKHDGTNFRNLLPGEYIQMAGRAGRRGLDTTGTVILLCKGDVPEMSELHKMMLGKPTCLESQFRLTYTMILNLLRVEQLRVQDMIKRSFSEFHHQKDTAVHRKALEELKQKMTGIKNIECYLCSLDLEKYYEDCREYHELQRYLQSVMLTNPTALKLLSPGRVLMVRRPLGQAVLGVVLASSVGTNNERKFTTLVLSEKGEEGLGEPSKHRVGPVLPSSLFLPEGASWQQVLELKSNDIARVTTKVIRVDADGIIHDTRRRDHPRFKDEPPDRCVTTATQELLRLSESNPSGLPGLHPVNDLKFRDMDLVEQCRTLQFLEEGFSDFNCPRCPVFLEHFSEHDRNMALKDEYRRLQYLLSDESLALLPEYTQRVQVLKRLHYVDNTGTVQLKGRVACEISNHELMITELVFENVLTDLHPTDIAAVLSCFVFEMKRCSEPKLTDTLLKAKEQILQKGEMIAQLQKEEGMKTPVEEFTEQFHFGLMEVVFEWARGMPFSEITTLTDVQEGIIVRSIQRLHETMSDVRNAARLIGDRTLAQKMEEAMNMVKRDIVFAASLYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYV2</accession>
    <name>A0ABM1VYV2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NXPE family member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827595.1">
        <property type="nucleotide sequence ID" value="XM_035971702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850981"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NXPE C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827595.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35519" checksum="76CE4E9570AB254D" modified="2025-10-08" version="1">MNCMDYDDNGATTTTTTTTTRTSRVTKTFKTPASARPDVIVNNLCSRTSAINTIPPCYKFSPLSTWESDGPRGFFDHALTWHSTICKEPKLVPQFLNSCLQNTHVWLLGDSNILRFFFLFFELTNCKWYLGNMTSPWPTYRYCNITDINFTMTFHPHEYHNYIQHQIHPTITSPGFPALLDAIPSTGKQIVVAHYYAHYTTAHLIVLWERLTALRDAIKRLVSRNPEAVVAFRGPHAVTKDWEINHSVGGDVLITLYLPMIREIFAELMDKVVFLDGWEMSVALENTLLHPTDKIPIAMIRTLLGFACEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZ05</accession>
    <name>A0ABM1VZ05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrator complex subunit 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827648.1">
        <property type="nucleotide sequence ID" value="XM_035971755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478323"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048660">
        <property type="entry name" value="IntS9-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21382">
        <property type="entry name" value="IntS9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 9-like C-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827648.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8859" checksum="B169880CF0D20CC0" modified="2025-10-08" version="1">WRKPYIFGSPSLQAIVEGLKQQGFTSLKVEENESGSIIHLMKEDSLIQVDGSSTHIICDSEDVRLRLRDVMLKCLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0C4</accession>
    <name>A0ABM1W0C4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PHD finger protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101851671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828117.1">
        <property type="nucleotide sequence ID" value="XM_035972224.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851671"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031946">
        <property type="entry name" value="KIAA1045_Zf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16744">
        <property type="entry name" value="zf-RING_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828117.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42327" checksum="4F7F6A094146B092" modified="2025-10-08" version="1">MGNNPSSATEDPEGAEGSSIPKSMLTKIQCMGHRLRVEERAELYRALAELREDRRRLSLDLLEEKRIREAGLTSKDMTSRVRDTDKPSWAAYENDPNCSLCGKPARRQEAYPCRVCTRIYHPICLGKCGECRDVDLQAAENALSNTGWSCYICSNLSLLLTELEINQLIDEFDMFDKNKDEHISWDEIMKHTHPALPAGRRREQLPSDERLEMRLSFKMADQDNDDSLDWWEFLNYQAKTLLAKRSKEELVSLLSEKEVIKCKTLFRSMDTDEDGVVTLLEARQAVRDWCQKYEHNMPPEEFSKLLPGLDLHSEIRAQMFVDGEDAHRESVRWPEFLADQSLYIISTRPNVSARHIESVLKDACHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0F2</accession>
    <name>A0ABM1W0F2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Diacylglycerol kinase</fullName>
            <shortName evidence="11">DAG kinase</shortName>
            <ecNumber evidence="11">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101848997</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="11"/>
    <dbReference type="RefSeq" id="XP_035828145.1">
        <property type="nucleotide sequence ID" value="XM_035972252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848997"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20851">
        <property type="entry name" value="C1_DGK_typeI_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20845">
        <property type="entry name" value="C1_DGKbeta_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.110">
        <property type="entry name" value="Diacylglycerol kinase alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047471">
        <property type="entry name" value="C1_DGKbeta-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029477">
        <property type="entry name" value="DAG_kinase_typeI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038199">
        <property type="entry name" value="DGK_typeI_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF48">
        <property type="entry name" value="DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14513">
        <property type="entry name" value="DAG_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="797"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="842"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="345"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="395"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="460"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="15">
        <location>
            <begin position="600"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="538"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="944"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035828145.1"/>
        </source>
    </evidence>
    <sequence length="1071" mass="118077" checksum="C25365A40BFE54B5" modified="2025-10-08" version="1">MSLLQWQKLSPSEFQQLQEYTSYSSKKLKDVLKEFQGDGLLSKYNPEEPIDYAGFQLFMETYLEAEIPEDLCKHLFLSFMKKAAMSSAAAALAASSGKDFHVKDMAVVASQTVCAPLSTELHYFAEAKPVGLTGPGGGSNSSASADGGGGSRSIGGGLAEKLHGLTEKLHGLGHSRSDSGAGDAGKRSRAGSGSAASHPSVAVAAASSLDKNHPDDSTPPDLSNHSRSSSKKSNHSIHSVHNGPLLDGSDPWIRQSNSSLLRTNVDLKAVRNRSMSLEIKTGHIYLKDLVCYLSLLEAGRPQDKLEFMFRLYDTDGNGLLDSCEIECIVNQMMSVAEYLGWDVSELKPILQDMMIEIDYDADGTVSLEEWKRGGMTTIPLLVLLGLDTNVQDDGTHVWRLKQFNRPAYCNLCLNLLVGVRKQGLCCSFCKYTVHERCVQRAPASCITTYVKSKKTSQVMNHHWVEGNCAGKCDRCRKSIKSYNGVTGLHCRWCHVTLHNKCASQMKPECDLGEYRDHVLPPIAVCPAVLFMTDAESHEDRGRGGGCGGSSGGGSGKNTLEKEKDQDKGEDSKSTTPQSENAQFDGPVSPGQSSFQITPLEGTHPLLIFINPKSGGKQGARLLRKFQYLLNPRQVYNMVKEGPLIGLQFFKDVPNARVLVCGGDGSVGWLLDIMYKVNFAQRPPVSVLPLGTGNDLARCLCWGGGYEGENLLKVLKKVENSNVVMLDRWKIEFSKPEDEDEQEGDPIPYNIINNYFSIGVVSGLCVCVLCYDMAWFQWPSSQGLRMAEVFSEKSSLSPLLFCVCYSLVTPLILGTYMTLMCCKCRKTLTKMKNPSHILRVTKPFICLFISQNPAYICVANLFIYLFVSPNSSHVCFCVLLRMKNKLWYFEFSTSEQFFSSTCKNLHEDIDIMCDGCSLDLANGPSLEGIAILNIPSIYGGTNLWGENPSQKKRRKAQKAKKEKDREFSTSSMSSAELAIAVQNVGDAMIEVVGLENIFHVGQVYAGLRASGKRLAQCSQVVIRTRKRFPMQIDGEPWMQPPCTIYISHKNQVPMLMGPPSSKKSKLFKIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0G4</accession>
    <name>A0ABM1W0G4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polypyrimidine tract-binding protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106013039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828157.1">
        <property type="nucleotide sequence ID" value="XM_035972264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013039"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12421">
        <property type="entry name" value="RRM1_PTBP1_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12693">
        <property type="entry name" value="RRM2_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006536">
        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="156"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="266"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828157.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="44805" checksum="9D1614CECE7E1EFE" modified="2025-10-08" version="1">MYVSYYPYGQPAVLSHQPPPPAPAPPAPAQAPPTLIPTPAHLPASLAPQDLLVSVTAAGVPTVTGSQVVASLAQHHQQQQQLHHPATGISSYSSLGPLVICRKVPYRSELKRGSEELMSNSPMVANGTGLSPHASPTELTDAKKAKLDGTINPPSRVVHIRSLPGEAGETDIVQLGMSFGKMTNVLVLKQKNQAFLEFQDEASAISMVSYFQANPAQVRFKPVFVQFSNHKELKTDASHAFQNANAQAALQAACVVMGSEEQSTILRVIVDNAFYPVSLEILHQLFNKFGKVLKIITFTKNNTFQALIQMSDAISAAAAKTSLDGQNIYNGCNTLKIDYSKLSNLNVKYNNDKSRDFTRPDLPTGDLNLDAMSLGGSSGVLVSPVPTYQGLAPAQLTAVGTVPAQQTAGNYSPLSLFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0M2</accession>
    <name>A0ABM1W0M2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118478529</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118478529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828215.1">
        <property type="nucleotide sequence ID" value="XM_035972322.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478529"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035828215.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19461" checksum="75DFEC4277FDF779" modified="2025-10-08" version="1">MARVNKQSAGGLMLVCGRARPRSVQTKRYLFLVRATEPPARLIAMELAASSGFDVAEVNFVGALVVQRLLRVRLLFNRWFNKPDPNDNRKNPSLHGARIKSAFGLRLVELRTDPEGSVFHHWEFLSQTPPTEFTLRRSKVSNMPADVSSITVMAEDSYGNIMKKRFKVDVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W120</accession>
    <name>A0ABM1W120_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450 20A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828363.1">
        <property type="nucleotide sequence ID" value="XM_035972470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852376"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052666">
        <property type="entry name" value="CYP450_20A1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24280">
        <property type="entry name" value="CYTOCHROME P450 20A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24280:SF4">
        <property type="entry name" value="CYTOCHROME P450 20A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828363.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="64741" checksum="53825C58AD898526" modified="2025-10-08" version="1">MFRGFQAAAALQQGTGDLSPEAIEVKGFSTVTSRTSGTIAAELDGNFSDIARAGSLHEFLLDLHNQLGDIAGFWWGQTYVVSIASPELFKAHAHVFDRPGTPFMQKVQIGYNTNNPVCPKTDERLIPPRRDTYILLNEFFHVSGELFKFVEALFGSYSLQYANGPEGWRRRQEYSRPFSHERLKKYLPAFQEVNRFSQEKANSWKRDFSLMFSGMESQHIYVDTGESPVEAEVINILAENVEKKWCKGESDPIPVGEDMASFSIRSTLSTLMGDSFLDEKLVQSVIKAYKTVWIELERRLTDSVPPDENDSREKLFSEEWFRLFSSVLALQHLHTTVKEVVEHRQENKLLDQQLLIDVILQYTTDEDMLISDIILFMVASFHTSANLLTWAMYFLATHPDVQSKLHSEIVQVLGQKGAVTDSNFGQLRYLQQVLQETLRCAVVSPWGARVQDVDSVLGGHKVPKNTPVIHALGVVLQNEKLWPLPKRFDPDRFSTENSKDQPTYAFSPFGFAGKRTCPGYKFANRGSTVLIATLIKKFEVSMWSDQVVKPVFGLVTRPHEEILLKVSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2W0</accession>
    <name>A0ABM1W2W0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101857291 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101857291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829003.1">
        <property type="nucleotide sequence ID" value="XM_035973110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857291"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035829003.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15669" checksum="9761C7413F06A23E" modified="2025-10-08" version="1">MKWLTHGSLHVHTKPKTWSAAVKQESQLTAAERMADDTDFSLDAAESAVSGVEVLVKFPNENVPQRRTVPVETGPDANGDNGGLPLTVAQVKRQLFAENRIPGNPDALTMIIKNNTGETELNNSDIFEDYIEHIATEAVIRFA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>P41823</accession>
    <accession>Q6EI08</accession>
    <name>SY65_APLCA</name>
    <protein>
        <recommendedName>
            <fullName>Synaptotagmin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Synaptotagmin I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>p65</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SYT1</name>
    </gene>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Proc. Natl. Acad. Sci. U.S.A." volume="92" first="11307" last="11311">
            <title>Evidence for synaptotagmin as an inhibitory clamp on synaptic vesicle release in Aplysia neurons.</title>
            <authorList>
                <person name="Martin K.C."/>
                <person name="Hu Y."/>
                <person name="Armitage B.A."/>
                <person name="Siegelbaum S.A."/>
                <person name="Kandel E.R."/>
                <person name="Kaang B.-K."/>
            </authorList>
            <dbReference type="PubMed" id="7479985"/>
            <dbReference type="DOI" id="10.1073/pnas.92.24.11307"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <tissue>Ganglion</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="J. Neurosci." volume="23" first="6238" last="6244">
            <title>Differential regulation of transmitter release by alternatively spliced forms of synaptotagmin I.</title>
            <authorList>
                <person name="Nakhost A."/>
                <person name="Houeland G."/>
                <person name="Castellucci V.F."/>
                <person name="Sossin W.S."/>
            </authorList>
            <dbReference type="PubMed" id="12867508"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>PHOSPHORYLATION AT SER-123</scope>
        <scope>MUTAGENESIS OF SER-123</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="J. Neurochem." volume="89" first="354" last="363">
            <title>Identification and characterization of a novel C2B splice variant of synaptotagmin I.</title>
            <authorList>
                <person name="Nakhost A."/>
                <person name="Houeland G."/>
                <person name="Blandford V.E."/>
                <person name="Castellucci V.F."/>
                <person name="Sossin W.S."/>
            </authorList>
            <dbReference type="PubMed" id="15056279"/>
            <dbReference type="DOI" id="10.1111/j.1471-4159.2004.02325.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH SNAP25</scope>
        <scope>MUTAGENESIS OF ASN-347 AND GLY-358</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Acts as inhibitor of neurotransmitter release. Overexpression leads to a decrease in the amplitude of the excitatory postsynaptic potential in dissected cholinergic and glutaminergic neurons while depletion with antisense oligonucleotides leads to an increase. Overexpression of isoform 1 blocks the reversal of synaptic depression by serotonin in sensory neurons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="1">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.</text>
    </comment>
    <comment type="subunit">
        <text>Binds SNAP25. Isoform 3 binds SNAP25 with higher affinity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasmic vesicle</location>
            <location>Secretory vesicle</location>
            <location>Synaptic vesicle membrane</location>
            <topology>Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location>Synapse</location>
        </subcellularLocation>
        <text>And vesicle-like structures.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P41823-1</id>
            <name>1</name>
            <name>Syt1VQ</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P41823-2</id>
            <name>2</name>
            <name>Syt1</name>
            <name>Syt1 C2B alpha</name>
            <sequence type="described" ref="VSP_013344"/>
        </isoform>
        <isoform>
            <id>P41823-3</id>
            <name>3</name>
            <name>Syt1 C2B beta</name>
            <sequence type="described" ref="VSP_013345"/>
        </isoform>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="EMBL" id="U03125">
        <property type="protein sequence ID" value="AAA03567.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY325502">
        <property type="protein sequence ID" value="AAQ91785.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191553.1">
        <property type="nucleotide sequence ID" value="NM_001204624.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191565.1">
        <molecule id="P41823-2"/>
        <property type="nucleotide sequence ID" value="NM_001204636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P41823"/>
    <dbReference type="SMR" id="P41823"/>
    <dbReference type="iPTMnet" id="P41823"/>
    <dbReference type="EnsemblMetazoa" id="NM_001204624.1">
        <property type="protein sequence ID" value="NP_001191553.1"/>
        <property type="gene ID" value="LOC100533340"/>
    </dbReference>
    <dbReference type="GeneID" id="100533340"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="C2DOMAIN"/>
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    <keyword id="KW-0025">Alternative splicing</keyword>
    <keyword id="KW-0106">Calcium</keyword>
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    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
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            <end position="428"/>
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            <begin position="1"/>
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            <begin position="68"/>
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            <begin position="286"/>
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        <location>
            <begin position="16"/>
            <end position="50"/>
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            <begin position="147"/>
            <end position="395"/>
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        <location>
            <position position="184"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <name>Ca(2+)</name>
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            <name>Ca(2+)</name>
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        <location>
            <position position="379"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
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    </feature>
    <feature type="modified residue" description="Phosphoserine; by PRKC2" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="splice variant" id="VSP_013345" description="In isoform 3." evidence="8">
        <original>ALLQGTKRLKKKKTTIKKNTLNPYFNESFG</original>
        <variation>SLMLNGKRVKKKKTTIKKCTLNPYYNESFT</variation>
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of phosphorylation by PRKC2." evidence="5">
        <original>S</original>
        <variation>A</variation>
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Confers higher proteolytic instability." evidence="6">
        <original>N</original>
        <variation>C</variation>
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Confers higher proteolytic stability characteristic for isoform 3 to isoform 1." evidence="6">
        <original>G</original>
        <variation>T</variation>
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 3; AAQ91785." evidence="10" ref="3">
        <original>S</original>
        <variation>C</variation>
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00041"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="12867508"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="15056279"/>
        </source>
    </evidence>
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            <dbReference type="PubMed" id="7479985"/>
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    </evidence>
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            <dbReference type="PubMed" id="15056279"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="7479985"/>
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    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <sequence length="428" mass="47687" checksum="EC58D0F2B08AF559" modified="2005-04-12" version="2">MDSLLARVKRAADADALNPAQEGVTGGPDAAGLPDVSTSSPGGGGAGDKLKEKMDEYKDKLINEIENLPIWAIVLIIAGSLLFLVCCVYCVCRRSCRKRKKKEGKKGLKGAVDLKSVQLLGNSYKEKVQPDLDELPVNMEDNEDAESTKSEVKLGKLQFSLDYDFQKGELSVNVIQAADLPGMDMSGTSDPYVKVYLLPDKKKKYETKVHRKTLNPVFNESFTFKVPYAEVGSKILTFAVYDFDRFSKHDQIGQVQVPLNSIDLGRVVEDWKDLQSPDTESEKENKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIALLQGTKRLKKKKTTIKKNTLNPYFNESFGFEVPFEQIQKVTLIITVVDYDRIGTSEPIGRCVLGCNSSGTELRHWSDMLANPRRPIAQWHTLQEVPEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R4VD32</accession>
    <name>R4VD32_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 15 16 17">Acetylcholinesterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Acetylcholinesterase-like precursor</fullName>
            <ecNumber evidence="14">3.1.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17" type="primary">LOC101860246</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Identification of acetylcholinesterase in the central nervous system of Aplysia californica.</title>
            <authorList>
                <person name="Carter C.J."/>
                <person name="Magoski N.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15 16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.7" evidence="14"/>
    <dbReference type="EMBL" id="KC618635">
        <property type="protein sequence ID" value="AGM37743.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001267763.1">
        <property type="nucleotide sequence ID" value="NM_001280834.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936378.1">
        <property type="nucleotide sequence ID" value="XM_013080924.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936379.1">
        <property type="nucleotide sequence ID" value="XM_013080925.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936381.1">
        <property type="nucleotide sequence ID" value="XM_013080927.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R4VD32"/>
    <dbReference type="SMR" id="R4VD32"/>
    <dbReference type="ESTHER" id="aplca-r4vd32">
        <property type="family name" value="ACHE"/>
    </dbReference>
    <dbReference type="GeneID" id="101860246"/>
    <dbReference type="OrthoDB" id="9000293at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014788">
        <property type="entry name" value="AChE_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF12">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08674">
        <property type="entry name" value="AChE_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="9 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9 14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004380847" evidence="9 14">
        <location>
            <begin position="27"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="10">
        <location>
            <begin position="29"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Acetylcholinesterase tetramerisation" evidence="11">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="8">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGM37743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="NP_001267763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012936378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012936379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012936381.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="71396" checksum="0E675AD2615FEAFD" modified="2013-07-24" version="1">MGLDYVIRLLAQCHVVLVLMTRLAGAQERPIIETDKGTVQGVTVFADGKKVDAFYGIPFAKPPLGDLRFKPPAQLDSWEGVLDASRLPNSCMQGFDRTFGNFTGSNMWNPNTPVSEDCLYLNVWVPRTNPPYKDKSVIVWVYGGGFYSGSSTLDIYDARYLAAENDVVVVSMQYRVGALGFLTLNTPEAPGNAGLWDQRMALEWVNRNIHKFSGNTRDVTLMGESAGACSVGLFLICDLCRGYFHKAILQSGSPAADWTALPKEEMWRRSESLASHYNCNKPGDPDYVIRCLRQVNATEFPIREPYMTHGIMQFAFVPVIDGIFIRQDPQEMLRLGRFKKVPLLLGSVENESTFFIIYINSEIFRLDTDSPLTAQDYRNLMTQQAFKFYPYYPHKLNDFGIEAVMFHYRNWINPDDGIENRKSFDRAVSDNYFVCSVNRLARAYAREGAPVYYYWFNQRWSANPWPEWMGTLHADEIWFTFGHPLNRTHSFTEAERELSKKIMKYFTNFAKTGDPNKAPGEVSSMEWPLFQENEQLYLNLSTDSLVNGPIWGAGPRAQDCAFWDMYMPKLVAETSDISEAEREWKAEFHTWKTRYIVDWKTQFDHFLHNYQRRMGTCGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBG9</accession>
    <name>A0ABM0JBG9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">5-oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101846472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089828.1">
        <property type="nucleotide sequence ID" value="XM_005089771.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846472"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="234"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="6">
        <location>
            <begin position="539"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="731"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089828.1"/>
        </source>
    </evidence>
    <sequence length="1297" mass="140945" checksum="8C9D1728C784DF0A" modified="2025-10-08" version="1">MSTKAANGKFQFAIDRGGTFTDVWARLPSGETRVMKLLSEDPENYADAPKEAIRRIIEQELGTSQKENINTSVIDWIRMGTTVATNALLERKGEPMALVITNGFKDLLHIGNQARPNIFDLEIVSPENLYQDVVEVEERMVLNQGENQSDGSNKVVTGTTGERLEMWTSLNVQKLREDLQKVLDKGIKSLAVVLMHSYIYKDHEELIGNLAKEMGFSNVSLSSNVMSMIRIVPRGYTACADAYLTPCIKKYIDGFKEGLQDAKVLFMRSDGGLTPMESFMGSHAILSGPAGGVVGYAETTYSRERRVPVIGFDMGGTSTDVSRFAGAFEHVFESTTAGITIQAPQLDINTVAAGGGSMLFFRSGMFVVGPESAGAHPGPVCYMKGGPLTITDANLCLGRLLPEYFPHIFGKTEDKPLDKAATLKAFGLLTSEVNDFLKEQGADPMTKEEVALGFIRVANEAMCRPIRALTQAKGYDTAKHILACFGGAGGQHACAIARSLGMSEVYIHKYAGILSAYGMALADVVYEAQEPSALTYSAENFAQLNERIAALEKKCQEELKVQGFDSDHIETQPFLHLRYDGTDCALMCTASPSSDNGMSCGFGDFYTSFFNRYKTEFGFTLKGRDIYVDDVRVRGVGKSQAASAKEIPKAAGPPVKEKTVKCHFEEGCLETAVFRLENLSAGHKMDGPVLIIDKNSTILVEPECQAEITPLGDIRIKVASQNKKVIGTDLDAIQLSIFSHRFMSTAEQMGRVLQRTSISTNIKERLDFSCAMFGPDGGLVANAPHIPVHLGAMQETVQYQMKTLGADFHDGDVVLSNHPQAGGSHLPDLTVITPVFHKSQPKPVFFVASRGHHADIGGITPGSMPPHSTSIFQEGAVFKSFKLVEAGDFKEKEVTEAFNDPAKYPGSSSSRNLHDNLSDLKAQVAANHKGIQLISDLIDEYGLNVVQAYMKYIQENAEVAVKDMLREIASKTKATTGKTELYAEDFMDEGTKICLRITIDEVEGTAVFDFSGTGFQVHGNTNAPRAITLSAIIYCMRCMVGHDVPLNQGCLKPIRIVMSPGSIIDPSEEAAVVGGNVLTSQRIVDVILRAFGVCAASQGCMNNITFGNEKVGYYETVAGGAGAGPSWHGRSGVHTHMTNTRITDPEILEKRYPVVLQCFKLNEGTGGDGQYHGGDGVVRELMFREPFTLSILTERRVFPPYGLKGGMPGQRGRNLITYSDGRVIDLGAKNSVDVKRGDVFRLETPGGGGYGPPGSENAEGDMEVEVSSSKKRKLEAKGNPQMQSGSLFSYKLMQESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBS2</accession>
    <name>A0ABM0JBS2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Fatty-acid amide hydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8" type="primary">LOC101847078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090021.1">
        <property type="nucleotide sequence ID" value="XM_005089964.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090022.1">
        <property type="nucleotide sequence ID" value="XM_005089965.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826181.1">
        <property type="nucleotide sequence ID" value="XM_035970288.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826184.1">
        <property type="nucleotide sequence ID" value="XM_035970291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847078"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF4">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="67"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005090021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005090022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826184.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="57190" checksum="0BD0447AC86DBAC9" modified="2025-10-08" version="1">MGFRRNVIFWSVSAVTYVVMTLVDALFRFLYKDKGKKVSRVSDPLLLMPASDVAEKIRNRTLRAEDVMAAYIVRAKEVNPLINVVVGEQYDRALRRAQELDARLDSLSQEERDREFSVDSKPLLGVPLSVKEAFSWTGMANTSGVPGRRHIRQSQNAPVLNNLEAAGAIPFIQTNVSEACMWFESSNYIYGCSNNAYNTSCIVGGSSGGEGSVLSSGASVIGIGSDIGGSIRMPCFFNGIFGHKASIGVVDNSGQFPIASEKAMCLLATGPMCRYASDLIPCLKVMAGPAGVAKLKLDTAVDLAKLRVISVPDDAGSILVSKVDPQLKEAQRKAAEHFRKKGATVTEQYFKEFRESVNMWAGKMNLSDDGPSFACIISGKEDGHVNCTLELGRWLVGSSSHTLPAIALGILNDYLPAMTKSADLKAVEKLDSLRERLVSVLGDDGVFLYPSHPKIAPYHHHPVCTPFNFAYTALFNALGFPVSQCPLGLSSDGLPLGLQVVAAPYQDHLSLAVARELEEAFGGWVSPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEJ2</accession>
    <name>A0ABM0JEJ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane progestin receptor beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091911.1">
        <property type="nucleotide sequence ID" value="XM_005091854.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853140"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005091911.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25521" checksum="258A086A099D6B07" modified="2025-10-08" version="1">MGLERATIDYYGVGQYSLGRAFLIIYVSMNDDVFPISATHWLLLICVLLSWTDFVCCVISQLKFHRPYPLLAKKLWQVVPFVVHGAFFSFLIAPRVRGCLTSPDCHMFWDQPGLYYIFLELIAGAICILTFSSHMPEKIWPGTFDFLGQGHQIFHVASVTMTMFQFESGAADAVQYYRAEQARPELWDILAAILLLKLACLTTIVCLKNKTLDCVRKESDMKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEL7</accession>
    <name>A0ABM0JEL7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101845220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10"/>
    <dbReference type="RefSeq" id="XP_005091964.2">
        <property type="nucleotide sequence ID" value="XM_005091907.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845220"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005091964.2"/>
        </source>
    </evidence>
    <sequence length="231" mass="25092" checksum="7733D7D8CB48522F" modified="2025-10-08" version="1">MALSNGCSCRIGPSILNADLSDLAKECQRLVEAGSDYMHLDVMDGHFVPNLTFGHPVVKCLRPKLPGVFFEMHMMVSEPEKWVEGMADAGADMYTFHYEATDDPVGCIRKIKEAGMKVGMGINPPTNVEVVLPYVDMLDTVLVMTVNPGFGGQKFMTECLPKIEFLREKFQTLDIGIDGGVGPKTIQQCADAGANLIVSGSALVGASNPRECISYMRGIIDSGLKEINSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEW3</accession>
    <name>A0ABM0JEW3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101863651 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101863651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N4BP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092131.1">
        <property type="nucleotide sequence ID" value="XM_005092074.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863651"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09032">
        <property type="entry name" value="KH-I_N4BP1_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18719">
        <property type="entry name" value="PIN_Zc3h12a-N4BP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056629">
        <property type="entry name" value="KH_N4BP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056578">
        <property type="entry name" value="UBA_N4BP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF35">
        <property type="entry name" value="LD08718P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23050">
        <property type="entry name" value="KH_N4BP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23054">
        <property type="entry name" value="UBA_N4BP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N4BP1 first type I KH-domain" evidence="4">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RNase NYN" evidence="3">
        <location>
            <begin position="601"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="N4BP1 C-terminal UBA" evidence="5">
        <location>
            <begin position="850"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005092131.1"/>
        </source>
    </evidence>
    <sequence length="901" mass="97999" checksum="83E5687E8944D8D5" modified="2025-10-08" version="1">MELGSRGGSPKDVCCVEFVISQSEVKKVERDRKRINDLFNVKLTFGEVFSKRAQDSKQWMSITGKNDDATSAKEYVLAIVTPEASALMKNIRFHPNFKEQDRADIERSTGAVLRWSLDNQGSLQISGSELAVVLAQSIIDELFASYTGEFTEHEDDGFILVGDVTSIEAASSDTPLNQNNSSTPSSSFKQSGFSSDDAMIISPEKQQGHASAAATASQRSALEGPPATFCPPGLPPYEASQTSSVLGASSGHVFTTSQSSKGEEMPNRALPSALSVRLGVPNSLGHVSNPGLGVSGWRPSVSNQQSGVLNHQSGGSGVLLGPRHQHHILGSGFGILGPNSGGPGDNQTDQTQIKVPLPSWRPQYGQNVACMDVCDSEPPTASSANNNNNTSPLSVQAEKQRVYLRDLGVSCNYSLGDIEIGLSRFSMEEVIIPAVFLSTLNEVKASRHSNRSVPPPPPPLGQGHVAATATTSQRTNRDNTGGQSMNVNANCTGASHSAVTRSEDVVVISSDEEEVKIEEPSSFRSNAAGLPQLPPMSLSLDERGNRTVHMDKGFENLRLGEVGSSSSSRPDLPGNVPATMRMPRTLSTNPSQASNATGSNLRYIVIDGSNVAMSHGENKRFSTRGLQICIDYFRERGHPKVVAFVSEAVRYSGNPIYLAGRDLLEKLNQDGFVKFTPARRINGRNITTYEDRFILNLALKEDAVIVSNDQFRDLHKDNPKYRYLIENRLLQFVFADDHFMPPDDPLGRNGPSLDDFLMVNPPRQTSIFPSSMDQAEVRGPPPPPPQPLARYPYSRWPQGPTTGHPRGGARNVVRPWRGDPAPDMSGDHLPAPRERQGHQKLTGLSLLPGRSEEETQRLFKQLSQVFCDPSQSSCIKKVLQNHKDETDINRLTNFLLSAMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF24</accession>
    <name>A0ABM0JF24_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylcholine receptor subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092237.1">
        <property type="nucleotide sequence ID" value="XM_005092180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848724"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005092237.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24323" checksum="84DE27E07387DC22" modified="2025-10-08" version="1">MSHKQTCSEAFGVCAQAANVPTMPSTVGVFRLQRLYYGITIAIVSFATAMTVFVLNIHHKGARGREVPRIAKKIFFGVVAKIMFIHLELDDPPASPKPGNGPRGLRCSLDFSSWTYDAAGLNLLTLGPDNQGDVSNYKNSTEWQLISYLQEREVYQTIEKNEMRLEDQDRRDAIKNEWQQLAMVIDRLLLFFFIMLTAGITLALILPGYYAQAAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGZ1</accession>
    <name>A0ABM0JGZ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methylmalonyl-CoA mutase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101852674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylmalonyl-CoA mutase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093465.1">
        <property type="nucleotide sequence ID" value="XM_005093408.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852674"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02071">
        <property type="entry name" value="MM_CoA_mut_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03679">
        <property type="entry name" value="MM_CoA_mutase_alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.240">
        <property type="entry name" value="Methylmalonyl-CoA mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006944">
        <property type="entry name" value="PRK09426.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF4">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="Cobalamin (vitamin B12)-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="7">
        <location>
            <begin position="610"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005093465.1"/>
        </source>
    </evidence>
    <sequence length="749" mass="82092" checksum="FDB7A17BA33F668C" modified="2025-10-08" version="1">MFHLRQIGVLRQHINCVKACSPAASRLASTQKPIDEEWYKGAAKELKGKDVEETLMWKTAEGINIKPMYSKADAENVAPEIPGKFPYTRGPYSTMYTHRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLPTHRGYDSDNPRVTGDVGMAGVAIDSVEDTKLLFDDIPLNKISTSMTMNGAVLPVMSMYVVAAEEQGSKQAELAGTIQNDILKEFMVRNTYIYPPDPSMKIIGDIFEYTSKHMPKFNSISISGYHLQEAGADAILELAFTLADGLEYVRQGVNRGLNVDKFAPRLSFFWGIGMNFYMEIAKMRAGRRLWATLIQEKFQPKVAKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVFSARVARNTQIILQEESGIPKVADPWGGSYMMENLTSQIYDAALELITEIEDMGGMAKAVASGMPKLRIEECAARRQARIDTGSEVIVGVNKYRLPEQETVDVLSIDNTIVREKQCARLAQVKATRDSAKVKQSLDAITACAQSGDGNLLALSIEAARHRATVGEISDAMEEAFGRHVASDRMVSGAYKTEFGEVDELQVVMERVQKFVEAEGRRPRILVAKVGQDGHDRGGKVIATGFADMGFDVDVGPLFATPREAAQQAIDADVHIVGVSSLAAGHKTLIPEIIKELKNMGRPDIVVVAGGVIPPQDYEDLFKSGCAAVFGPGTRIPDAAVQVLKLVEGELSNNNKKESAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHG4</accession>
    <name>A0ABM0JHG4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytoplasmic dynein 2 light intermediate chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101856789</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093750.1">
        <property type="nucleotide sequence ID" value="XM_005093693.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856789"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040045">
        <property type="entry name" value="DYNC2LI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236">
        <property type="entry name" value="DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005093750.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39394" checksum="1F27829AE6CC036B" modified="2025-10-08" version="1">MMEKSLWDLAIVQAHDNKEEQSSSEESAIFLIGSRNSGKTSIILRFLDRDEPPKPTVALEYTFGRRPKGHNIAKDVGHIWELGGGTWLSKLMDVPINPNTLLHTTVVLVLDLSAPNEMWFTMETLMTAAKARLEEAINEAKSTDPYIKDKLRKKAMERVGEENPDKSMMDLFLLPLVIVGSKYDVFQDFDSEKRKVICKTLRFLALVHGASLQFFSVKQEQLVSRMRSLVNHHLFATAAGKSLQVDHNKPLSVPTGHDSLQQIGTPPLSDSDIGKIQAKTPMELWKVAFCGYFQQTSANNPAMVDDPAKDPQFAEPAIDTLRAQKDEELERYRRLAERRAKEARSGYIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHV2</accession>
    <name>A0ABM0JHV2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852460</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093996.1">
        <property type="nucleotide sequence ID" value="XM_005093939.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852460"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046058245" evidence="1">
        <location>
            <begin position="26"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005093996.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24465" checksum="07ABE5B0E504FF99" modified="2025-10-08" version="1">MFSVSTKYVSLAILAIFSVVGTALASPVSQPTIDNPCRITSSAPPEYLPLQEEIALTLNVLETLRSSCEDGVTTMNTENLLTSDEIDMLMNNPMYNLPGLPLATATRNVSEEKMASILLEDYHDVSVFTVFAQQVYEEEDGNEVLKADLLKVKHYFYSTLCKLDTILGSINSHVSDFVSCDVMPDSLKNITSDKYRYMRAFLLLNSAMKHIEVLHTDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI60</accession>
    <name>A0ABM0JI60_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Krueppel-like factor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094167.1">
        <property type="nucleotide sequence ID" value="XM_005094110.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850318"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005094167.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="52307" checksum="876491C8DFF15BB0" modified="2025-10-08" version="1">MKELLESVSMNELNLMLTEDILGPFSDQKTLNELNDTPDICDDLDFDPSIGLFNFSEDALMQDYLFSRGTGFGTSDPGFADFRSAVTSLNSLGNTHEDDRKSRDLDFLLSDPTELSRSNEKSGPLPHVEEAFGVHIKKENKFSRNFSSNVGGLTSTAPIDFPCPEREQCGAGEIHGGHFGSRDEMLSSSESSSSCSEGGWEMSGEDNKDMVVLGVDISNLMHDYAIKTPPAHALAPTPPTPPAPARHKGSTKPVGHLVPSHFLTINGNTQACVYAPPVSSPASPANLLPSTDTYVITTSTSLLHKSTSLLENRARTTNPRLRLPNGAGHLMTSGVDPMLGNYTAEPKSPSGSPSSLCSLDSSSGFSTSSFSPSSSSLLSSSPSGHVNKLEDKIYPCTYQNCNKIYSKSSHLKAHLRRHTGEKPFHCSWPDCGWKFSRSDELARHKRSHSGVKPYKCDVCTKCFSRSDHLAKHRKVHRKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIR2</accession>
    <name>A0ABM0JIR2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EMILIN-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101845081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005094580.1">
        <property type="nucleotide sequence ID" value="XM_005094523.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845081"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF50">
        <property type="entry name" value="COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046253265" evidence="4">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="136"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005094580.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="28687" checksum="43188066F5ECFB1E" modified="2025-10-08" version="1">MFKLCYWGVTIATLVICEATVTSAQIGNQRDAGDTLGAERDSTGSGNNVGVADQEGGGDNSSKTGNQNNPWVAGNTNCSCMRELNALKRDLREEMNQRLALKAALDTYVSELYDLRNQVTANYSKTPAPNAIAASPSASSVAFSAKLSYNRELKPLDTVVFDTVLTNEGDAYSPDSGKFTATGAGTYLFHATILSGYNTKVETAIIVNDKEVARIYSGAHDAHGSGSNMAVVDLRSGDLVWVRLLYQGGNHVHGYYSTFTGALLQPAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKH9</accession>
    <name>A0ABM0JKH9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Aminoacyl tRNA synthase complex-interacting multifunctional protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC101857102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005095845.1">
        <property type="nucleotide sequence ID" value="XM_005095788.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095846.1">
        <property type="nucleotide sequence ID" value="XM_005095789.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936525.1">
        <property type="nucleotide sequence ID" value="XM_013081071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857102"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042360">
        <property type="entry name" value="AIMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041503">
        <property type="entry name" value="AIMP2_thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13438">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13438:SF2">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18569">
        <property type="entry name" value="Thioredoxin_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIMP2 thioredoxin-like" evidence="7">
        <location>
            <begin position="313"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005095845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005095846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012936525.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="55485" checksum="5BB06526585AC663" modified="2025-10-08" version="1">MGNQVSRCAHSMRKLWRPCAGKRPEDEAMLNTCDSEPLDKPLCDTSVSGGCRDSRSRSCSRDGSHASLVRLHDKMERVDCRITSATNVSSGTTTSTPKCGRFRFCSSGNNKNHHQNHHVNPGYRSLTSCCDADDYEDEGNGGGDCGTTRSASSAAGKRRVDRESQTSFAAGTCASDGDVSRSTAAREPCVLSKEYIVKTYSIQNATPSPASQSKFPSSGHTTTSQQQEKRSETSQSETQGSSSGNSPLATLERRQEDVLKRLEQLRSSVSKLKQQYNVQDEPPKTATTVAATTTTPLGASSTVASPLEQGQVMLDLVISADPSSVPLSLLVLCGQLCERYAVLKATYVHSSVSDSVPDNLRGLLSSNGGLKRSDAQVAITLVWKKVVNGPQLMVDPTKQTTIMGEVNIARYITRLLQPAVDSEDVVKATQVDELLDLAQLQLVSGNAKEKAAAVRTLNANLGKQDWLTGASPSLADIVLWSVLQQTGQASSPPANVKKWLALCQKHSLFQSAVAFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLP5</accession>
    <name>A0ABM0JLP5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101858932</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101858932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096618.2">
        <property type="nucleotide sequence ID" value="XM_005096561.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858932"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF30">
        <property type="entry name" value="MEMBRANE FRIZZLED-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045192810" evidence="6">
        <location>
            <begin position="36"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="8">
        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="144"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005096618.2"/>
        </source>
    </evidence>
    <sequence length="398" mass="44219" checksum="8222C96EC74165F5" modified="2025-10-08" version="1">MMTWRASPPRPGPSLMVSLLLLGVVISCLLHTCSGESKSACFSPANRTIELDCGEGRMLHIRRTFYGFSPSGQCRLVEEEVGEEGGEGCTLDEHVHYNCVGQQTCSINLPTGQWGLTVPSCGKRSNYFQVEYTCVAASSVSDICRHEQLTSQSGYIMTPNFPSNFHHQGRCTTTVLAHPSQTLRLHIIDMDLQDSSSADCADLLYFNDKLRSITLCGQRNNNSYNMHSNYLHIELQSTSNGRSKGFWLYYEAFPPLPTSLLPPDVKEEGPADDQEGGKSPVDGMQGDASDGQHPESETTQRPYKHPKSTVPLYRSSGHKSKPLPFAAIAGGVIGTLSLVLIVLLLLLLIKWYRERRYNKVEKVLEIRNPAFRSSTDFHEAHTQHQQASLPNNNSGYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNM6</accession>
    <name>A0ABM0JNM6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101861279</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101861279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097916.2">
        <property type="nucleotide sequence ID" value="XM_005097859.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861279"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005097916.2"/>
        </source>
    </evidence>
    <sequence length="335" mass="38513" checksum="3737801567E6DAB4" modified="2025-10-08" version="1">MHFRRGVNIFPEAICSCSQTGQAGRCSEFNTQRSEMEAERPQGYREYQSGDTSWDALGMRIKWTVPEVPGESVVHMLDPLCFKLCLECKKPVPLRDVSAWAWTCLYHTDNSEGIYREIRLPYVENSRQWDDNGVTTYLFSAVVFPTHTDDFRLTYNIKFRDSMIWVDKFQTDHIVTVLRPREVNQWTKQAEMAKITNRIFIGNFLSVILAEELNFEAVITLDKHLQGTAAEGVHAGRVKEEFHNFALEIGAGHEIPRDKVDVVVKRLKTLSDLHAHILMGDLDGQGRVGSAMTAYIFANNPHLTYEEACEFVKSQKMIYCHRGLKSTLHDMYPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPR8</accession>
    <name>A0ABM0JPR8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-galactosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101857570</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyses the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005098659.1">
        <property type="nucleotide sequence ID" value="XM_005098602.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857570"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="87"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="219"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005098659.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40297" checksum="29A2C48A8A6F06F9" modified="2025-10-08" version="1">MWPSARSAICSSCGIRFVKSSVRGQGRLILCLLILMLLTSLIVSFAYTVGESSVVGTSLGSLHHQLFYSKKNSRELRECHFAFNDTSKGPIEADTVSVPGIHELEEMLGPDLMPGGHFVPRLCRSKTKVAIIIPFRDRRIHLKIFLRHMHPFLQRQNVEYGIFVVEQEGVTPFNRAILLNIGYVESEMLHHYDCFIFHDVDLLPLDDRNIYACSENPVHLSASIDTHDFKLMYNNLFGGVSALTKEMMLKVNGFSNIYFGWGGEDDDMSYRVRSHGMDIERYIPEVARYTMMKHAKADGPSRYRLFASSRDRIHSDGINTLKYERIDIQLLPLYTWILVRINESEILEPFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRG2</accession>
    <name>A0ABM0JRG2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hemagglutinin/amebocyte aggregation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101850481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099814.2">
        <property type="nucleotide sequence ID" value="XM_005099757.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850481"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040">
        <property type="entry name" value="DERMATOPONTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040:SF3">
        <property type="entry name" value="SI:DKEY-14D8.6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005099814.2"/>
        </source>
    </evidence>
    <sequence length="160" mass="18368" checksum="19133ACD735DCB8D" modified="2025-10-08" version="1">MSRGGAGFGSVSILSVHDNNKEDRVFDFTCIPLILLYFPETFVELTCEWSNYVNDFDQLIEYQCPNDNVVAGISSYHDNHPEDRRFKFYCCRPNDLVTHGCEYTGYVNSYDQLLNYTVPDGWVLRGMTSVHDNSKNDRIFQFDVCRLDRLQLNPGASVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSA9</accession>
    <name>A0ABM0JSA9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box/LRR-repeat protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">F-box and leucine-rich repeat protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101862587</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005100377.1">
        <property type="nucleotide sequence ID" value="XM_005100320.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862587"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12109">
        <property type="entry name" value="Hr_FBXL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045808">
        <property type="entry name" value="Hr_FBXL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="17">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005100377.1"/>
        </source>
    </evidence>
    <sequence length="839" mass="93114" checksum="2CF7FE770D43B599" modified="2025-10-08" version="1">MAPLWPEEVDVFTVPHSRMKKLVHKYSKMILSADFANETRFKTLLQNLHNVFLEFKAHERIENMLIMRKLRYKLRAASVTSAAVCNCHSDNRLTDMLELVSDGYKWTDKTDYERQVFGVKLREALEDFTENFIPHMEEEEEVFQPMLMEYFSYEELKDLKAKVIYEHGVSKLKESAEHYDSEKFVEDESEESSEESPEPICHADLVPNEICLKIFSYLDPKDLVRAGQVSHRWNQLTRDPSLWMELHPVHWAQGNWTFYPEVTGGVDGAGALEKEYVADPEDEDAYLCVDEDADVDESCESDFSESPQSVELKRILREAKMITAIVKYLLPQVGSGVKVCDLAYSKGISSSLVHKILKLCPNLETLDLTHTRVGDEAFKEYGVSGRQSRLRHLDLTGCSHITDLTLFSLADANAVYAYGWDEIEDDEKERMEVDIEALPPPCCQLSSCCDKKSGFGVNQETSEQGTVDSGSTLGSYSSLSECASCTDGEGNDGFLTASDCCDVEIERSRNSSVGSSSDSSTTECRPSCLAEPFLSGTEQEESWVLRESCCNVLAKPNETNQVPVDGSLQVSDIECDLGGLHLARLLNSETTSHAADSCDPHCDISMGTSPNHCSFSGEGQAVKTKTCCAEKVVEKKMCCGERQRDDSASAPVNRTGSGENCSGNSSSVRQRHGCSESNRNVCMCGAPTCLSSDGRSEERPAPSYRPQEPPCCQSVYCAAEPKSGDDSVWVSDHEEDEVDQEVFTSQLQFLSLNGCYRVTDEGLWALAQGQGIPELQHLDLSGCTLVTGTGLAPLVSTCRQLDLSNLFYCDNMADDPFHAAASGCRNLQCGTRYCCSYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSD5</accession>
    <name>A0ABM0JSD5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AT-rich interactive domain-containing protein 4A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100421.1">
        <property type="nucleotide sequence ID" value="XM_005100364.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852699"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024812">
        <property type="entry name" value="TPR_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47050">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47050:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 24-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100421.1"/>
        </source>
    </evidence>
    <sequence length="893" mass="99719" checksum="4258503D1530AB1C" modified="2025-10-08" version="1">MTMDKLEGEAVIEVERLSKLGTARFQQGHKKKALEAYRNAHKASQALGQFGYIQRACAFNLGAMLISYGNFSEGLLYLNQAVPPEGKCDGRSNGDLFFNYGLAHEGLENWSESVQYFRKALKEYESEESNMKMETDTIQRLAKLSKEAGFFQEADTWLQQLTAAYNKSGEREKSLQTQAEHARLLLEKLGRADVAEVVADQCFESVEKCPSSKVLGYVLVELVLVYTQTHNYAKGIQCCEQALSLHGMIQAEPKLAAVVFQNLGAIYNHMKQYESAVEFHAKAAEKHAVLKDRRSQGHCFMNMGYAYSQIGDMGKAGDFFLHALQAAKDCGDRKTEWQSLESLGAVAYNDKAFNRAQTYYRDALTAFAQSPEAASVETQERILSKLKEIIQQQIPKAPQKIDGSNFAGKGSHVSEGEGSSSEEEKENEKVDSPGTKVEGRVFAVRRNSGGVKYLRVRRSGTLKRFKKVALGLDDELTNTGGSHHPEVFRLFKADVKGKIPSGDEESLIGANDPEDIDDEELENGPNVVELRDGNRKRYVKIRKSGSLRKFKAHGSGAKNGEEERIYEVLESDGELDPEDGLTSQEDEDKDDEEDVESTKIRHQRPPDSYVKSPGRKVLSDTMSGSEEVEEVGDDNSDDDSEKEEQKKMRAAMAKFKDATTLKEVEADVHVQARRGDGDSSSEREEETSEESESDDDEDATERRRGKAPTLPSRPPPDTGEVRTYERPLNNSEKIYETIDHKPPSGRGRDGDHVHFKGEQESGSLYSRRASDLDGHNYFHSDEEPMRKMKEEVSTGGDDPEGGEKNDSPSLTPSRAPTRRGRNTPGAEDGSEDEIVDEAKDDGDDSEETPELSRGQSDMLQYEQFKSDMEGKRLRNQDEQEKGDQKSSKHCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSR7</accession>
    <name>A0ABM0JSR7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBL-interacting protein kinase 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100654.1">
        <property type="nucleotide sequence ID" value="XM_005100597.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846216"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100654.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31194" checksum="A0DACDC62E35DF0C" modified="2025-10-08" version="1">MSSVEQISVIQLPKEVDVFHYHRMQYSSVLHQGQRSKILLARSQIIPDKKFAVKQMPLRSDEDRDRFSREMWLMKLASDIRGVVTLLPRPVFCGPTGYLIMPFYDKRDLLSQTGKLSHDNWMKVFVRAAVSLRSLHKKNIYHQNLRPENILLSTRHVAFISDFGAACLLSEGCDKVDTWTAAPGFRGPEADKEDGQLCPFQLDTYSLAVSMWQVLTGLCPVKNKPLDHLDNIPPQYAALLRNLLLPDPDMRWTLDKFLTEALELHPDLSCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JT95</accession>
    <name>A0ABM0JT95_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 729</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100959.2">
        <property type="nucleotide sequence ID" value="XM_005100902.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857884"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="931"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="968"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1153"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1260"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1378"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1408"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1437"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1498"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1603"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1631"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1659"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1687"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005100959.2"/>
        </source>
    </evidence>
    <sequence length="1803" mass="205517" checksum="5C3FED67DFB89BDD" modified="2025-10-08" version="1">MADVNKHCDNQTGQGSTDSDRISEELKSAASALLELLKNKNVNTTDLSSVKEIHELANLLSQSNRGIEPTGENKSKVDIPGFSATSEDSSHGFGCKILDHCIPDVQVTMGQDHDTDSLLSDTLTSKVQSEKSKSSVELRDQISAEDEDMVHALTETYEVPHNIVSAKVLTSDQWEGGDDKNCVEKIKIEEDMNPSTSMDLDAMVVKVNSSSSGNTSYAILELGSSRMAIENMNVISENVLIQDIKTENETVSGVNLLEEHLDGDHVLTKTKFMMKSWNKKQDGEGKPHHCRLCGLRYQKKCALKRHMIWKHQEYLTAQGLFDKLKDLETVSTGQCFKNMESSLHTESKNKYVCPLCGKLFKQQTYLKAHFLMHIQDTPYFCKFCRKCFKTDVMLSDHMMELHASQFKMKRKKSTHDGSADIRTSMSLKCSECDKTFSSKKSLEFHLEIHKDKKHYACKLCDKTFLQHRIYDLKRHIRQTHGKLEVERHILYLDSSSLQDVSYKNEPGERRKEGSLRKNKKDSKSSQILFKCPYCPKVSKYSGNLKYHMEIHTNDRKYSCKICGKAFLSHRKNDLQRHIKQTHGIAENAEKYMKYLAVKKGDSASSADHQSKGELFTISEGGVEIPKKRGKPSKLVGCEICGDVFKNKAELQVHALEQHEEHYTCVPKVEALDHDSNITSIIIDDPFAGPSGSSSVDGSQVLPHDVPPSVVANVEDVNSVLSSLPYHSCDGDQVKTVVKRSGPGDDSKMYKCPLCPKVMKYAYSLKYHMNVHENAKGFACRLCNKTFLTHKKYDLKRHIKYTHHVTEVEKYIISADSLSHRNLILKQKQLHVSAAHEKDKKAGDVGISEQKQDRRKQVKNVRKSKRITARKSKEIQEDDVSINIIEISSQNACTTDAVNSNETEYECPVCKELFHGEVQFKKHVGSHKSKKYVCHLCNKSYDNIKVLRSHIKQTHVVGNSDLINEAIDLYCSNCGQQFFSSQDLERHYLRRDCAMLGKKQQSQNRNLRKAEVESVYERNESTLETNGIPTGSDTHFESVVGKDIGRARRKPPVLKSVYICFYCKKDCLTKKYLVQHLWTHERTKRYRCKLCDMSFNRIFELTMHMSDSHENEQIPIDELSEAGQKHVCSLCGESFKNRYILKNHYVIHNGTKTNKCKICDKMFTRYSDVKRHIRQMHDRQENIRDLDEFVERMTVEDATSASVSNEHVGFGGMTGTLPVNCSFSDETQNNSANFGEPEGLTLPEHISITEENTDRELSVPLSCDVCQSEFSSVNALQMHRLVHVLPEREKCEFCDKSFFHLDRHIWEMHEDEVTAKSKEDSNAVTEHGESCRSSDFSCELYLCVLCGNETSEPRSESGACSSCSLLAHQNVSEVQMPHYCCSICGLKVMDADTLQRHLASHEEDKERPHKCDQCEKAFKTKRAWELHVIDHSNSKDCYCCEECGLTFSCLYKVRRHRHSVHQKHKPKATHFSCHICLFKSKSSEHLWDHLDIHSSNDELVCPFCDKVFMGPGELAVHGRNVHAGSDRQFSCPRCHFVTEEKYLLEKHMRVMHPEFQGHSCNFCESKFLLLHDLRFHVISKHEKKNTRNLSIQELALRGKYKGPFPCTECPKIFQRRVSLNAHMRVHFGVYKHACDFCEKKFRTPAEWRIHRRLHTKEKPYACQYCDATFSRQSSWVRHKRKHLGELPHLCEICGGRFTALKGLHKHKLIHEREAAREGSAAQQTICVEAIQADTSQLAQIPMNVSQSTVTSFVVKTIPEGDEGSTYETTYILPSDSIVIETGDGTADIILATGGTYQAAAYTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTD6</accession>
    <name>A0ABM0JTD6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101855500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005101035.1">
        <property type="nucleotide sequence ID" value="XM_005100978.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855500"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005101035.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11097" checksum="AEA330646D6A18E0" modified="2025-10-08" version="1">MDKRSVRVWMDGSFDLLHCGHANAIRQAREFGDELIVGLQPSADIVVHKGPPVFTESERHRLLAAVKWVNQVVDRAPYGTSESILDQHGCDFCVHGGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTF8</accession>
    <name>A0ABM0JTF8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteolipid protein DM beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101074.1">
        <property type="nucleotide sequence ID" value="XM_005101017.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845556"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF12">
        <property type="entry name" value="M6, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00214">
        <property type="entry name" value="MYELINPLP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101074.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28737" checksum="5EF50FDBF822C178" modified="2025-10-08" version="1">MAKYFDCLGRTPFASLLAALMVVIGTCVFCGTSFKALQLMIQGVFNNLFHFSVDWLEVLQVMFVIVGVVMGAFAVILLIFGFLATGATRSNIYSGAKCIMGGRLTAAFLMIVSYLLTAAWLVILSVCVVPVLLYASVSAICDKEIYQHTADQLKGYCFNLTRFGVYGLETGADNICEHSDLRSMCNKVEEAGPMFCVACGAAFLVVLGMVNFLITLAANYTRIKISRELTEYRDAVEQEELEMQLAEKRGPPPYRDGSITLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUT9</accession>
    <name>A0ABM0JUT9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101849855</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102027.1">
        <property type="nucleotide sequence ID" value="XM_005101970.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849855"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024868">
        <property type="entry name" value="FJX1/FJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13147">
        <property type="entry name" value="FOUR-JOINTED BOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13147:SF5">
        <property type="entry name" value="FOUR-JOINTED BOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02072">
        <property type="entry name" value="4JOINTEDBOX1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102027.1"/>
        </source>
    </evidence>
    <sequence length="771" mass="87508" checksum="29AC9DCB9C3034E1" modified="2025-10-08" version="1">MVVGRRFFLRHCRTKLVSVVALILAVSSLSLVMVTQSGSHTVAITHRRTHLSLLGKNSEGENPRDGGDGEEENILDQQTDGGSDLTLEYRAFGTEVKIAKESRKEQISSKRESKEILNDDSSSFLDVLTTGGGKLPDKLMDARSSHRRLHLPPVRSTEHHNREIYVEGDNSIKQKASPRQDGRIDRMTQYEEFRLPQYYHLQHEIISSSLSQPFHSRPLGSREDRYKSVQSIDSPSPKSAGFPEAVLKIVREPSNKNDDIPSQEPSSLQNPTLHRPQLQRTDAHLVKTKQPQSPRLEIREQGRLDNSYYYLPKSVPKTIPLFTNVKERSNNGEGEGSLDKRPTRESVMNFRSKSLSPSHIGRDIGVGDSVPKVPKEDPGIGSPHTEQSRRHENASKMPGWLSASQVVVDGIYWSEEVKRSIPKGVSVEVADRWINKTRRLGFQSLTPPDWNKCGRPQNGFVTLEDGTEMCARYRHPHDHLVMGEVLSYWLSRLLSLDCVPPVSLSLVSSAQWAELNKSKTDLGWEPEQYVALIMWIKDMNSSFRSKVLMPQAILHAYKTGVPVSEQIFLQAATVRTAQTNQSSDHNDVTNSGGPEWTVDELVAVAQWSSMIVFDYLTANYDRVASMQDGAEEQRKPEVIEESIRNLRRSRDSAKLWLIDNESGFLDAYDLMYTSPHNGHRFFRFHDQMLKTVCVFQRSLVDALRDLHAAESPRKKLEEFATKSDPFLRRIPKSSVYRTFEEHFDERLNAVIDWVDQCERRGGKDGGVHVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVI2</accession>
    <name>A0ABM0JVI2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101861372 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101861372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005102520.2">
        <property type="nucleotide sequence ID" value="XM_005102463.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861372"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="233"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="401"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005102520.2"/>
        </source>
    </evidence>
    <sequence length="446" mass="50604" checksum="6EE56956278089C3" modified="2025-10-08" version="1">MKTKNSKQETALSLAMRSDLPLDTERPIMATIQEGANFQTYQELIDALRAFERDNHTLFIREGSKRFKGDGEVAQRLVYELLTFACKQGKRRQPTRSTGTRPNQKTFKVDCPARIRVVCKEVEGRCVLQVNKADLEHVGHPVGAEAFDLYPENRRYVADDEFRRLVLAGTSISGLKEYISTKYNKSLRNKDIYNYRRRICAEAGVSTGDSNSQTKGKKPKKRISGTDTTVAEQVVAEVQKRPQLYDYQHPAHTDKVAVEVGWAEIGLILDMTAENAKNMWNKLQRSYLRFKAKQASSERGMVNTFHLQEQMAFLDQHITVICTEENPQVSFELEEVEFDEYAHVQKCEDASGAMVVKPSLPSGGSSSVRAPSAGTAVIKHSPPKRMSDPFDSAWESRFNNRDPDLDFLQGLLPQIKELSKSRKREYFHSISSMLFTCLKEQDEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWP8</accession>
    <name>A0ABM0JWP8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zeta-sarcoglycan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101847889</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sarcoglycan beta/delta/gamma/zeta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103318.2">
        <property type="nucleotide sequence ID" value="XM_005103261.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847889"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006875">
        <property type="entry name" value="Sarcoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039972">
        <property type="entry name" value="Sarcoglycan_gamma/delta/zeta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939:SF10">
        <property type="entry name" value="EG:4F1.1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939">
        <property type="entry name" value="SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04790">
        <property type="entry name" value="Sarcoglycan_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005103318.2"/>
        </source>
    </evidence>
    <sequence length="300" mass="32012" checksum="E1274EFCE44C6178" modified="2025-10-08" version="1">MESEDTNGILDYPPPSPQPVGIYGWRKRCIYAFVLILMVVVIMNLALTVWILRVLDFSVDGMGRLRIVPKGFELRGEAEFLRPVYVEEVKSLKGSPLYLQSEKAVEILAVSENQTSSSSVVVDSDSIQATCDVFKVENSKGDVSLMLKDGKISMSSTDVAYSGNIKFDGSVSTPSVMSPMETNLQIRADSSKVQVSGMGGVVMDGDLGHVMVTATEDICVTSTTGAIHLRSQDVVIKGLPGANSTTSSSSAPSRPYSPPSYSSFTPAVAQVFQLCLCGNGRLFLGLPSGDCRASASICSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JX55</accession>
    <name>A0ABM0JX55_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101862815</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103641.2">
        <property type="nucleotide sequence ID" value="XM_005103584.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862815"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47824">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47824:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005103641.2"/>
        </source>
    </evidence>
    <sequence length="487" mass="54541" checksum="FCCC97819F17327F" modified="2025-10-08" version="1">MASNGIDVYVKMPSGRSAQYDVRNTLKISGLCELVAKDEGVDACRVRLKYQGKTLDGNKTVGQYGVRVETILKAEILVPKNVDLVVELLDERWSKEIVISNLEPVSALFDIISEELDEERNKLQLQIAGKNLPFSSSSLMEVGVIGGSTITVSKKVEEEPVTKNASNAVLDSTARQEILSSFDAHGRNVEVVFSFDTTGSMFQYLTEVRRKLKECCRQLLQQIPNIRIGIIAHGDYCDSSVYVIKQKDLTSDLETLIDFTSTVGTTTGGDSPECYEWVLRKAQQLDWAEDSAKALVVIGDLFPHPPSYTDQNISWREELDLLSGMGVKVYGVQAGRNNDAVNFYKELADVSHGCYVNLTHIDVITDMFLAVCYRESDDGMLENFEEEVASKGEMTEAKKEMFSQLKQKQKEPQSDSKSKAKENKRYVNAPWWDLSKDNGSPQYCYNSNEDKWTPYEQLQSTVSNPVERKSAGSRSSGRRKKGRCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY88</accession>
    <name>A0ABM0JY88_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysophosphatidic acid receptor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101855890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005104375.2">
        <property type="nucleotide sequence ID" value="XM_005104318.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855890"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="51"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005104375.2"/>
        </source>
    </evidence>
    <sequence length="358" mass="40367" checksum="0BD4CF0AE8EE26DA" modified="2025-10-08" version="1">MTLYADNLTSDLTPAPDLPGQGQILTAHEFFVLKWFLVTLQAVVCLFGLVTNIINVVVFGKMGVAESATSLSFFSLAVSDLGFVATYSVYVILLVYRVFGYDVSYNLFVMFSWMFFYNVSTAITVYVSLQKMFCVAIPFRFKNVFTLRRTAVVLLVTTVVIASFYVPVFATLYIGEFRDSLNNTTRLAVAYRPGHRGYRRDYEISMQYLLPFSAQVIVIICLIVLFNKLSRASNFRRQNLTIKTTKDDSANSGAFQLSGKELQAVKAVLVVAAMFVTCNLPPVRSTTASLLEPDFQEFGRYFRLFFAISYGRFTLMTICSSLNIVVYATFNSNFRHTLKAMSPSCWREENGVDTKIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZD9</accession>
    <name>A0ABM0JZD9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101849787 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105118.2">
        <property type="nucleotide sequence ID" value="XM_005105061.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849787"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005105118.2"/>
        </source>
    </evidence>
    <sequence length="193" mass="21224" checksum="126624206E326F97" modified="2025-10-08" version="1">MSLCPEINVDSSECTTELDANIVEGWLNVWEIDHELENHVFGAGRYPTPRWEPHFCVLTSDASKIEFLKSEQERVEDEKTEVSCGCTRVRLDGGREHFERRWGYKTLAVLREDTQGGGGSPLPGAQEEGKAEGGSTEEKEEVVVVEVVVEDVDEGEKDAAASSDADSASAESFFRARTNLDCHDALPGESTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0L1</accession>
    <name>A0ABM0K0L1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sex-determining region Y protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Testis-determining factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101857896</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRY family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105939.1">
        <property type="nucleotide sequence ID" value="XM_005105882.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857896"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="215"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="215"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="284"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="379"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005105939.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="63276" checksum="F7E7E52DC240FDC0" modified="2025-10-08" version="1">MELPSPVPPVDSSSFYPDVLNDDMMRPDYFDSTHTFMDFDEGPYSTYDSNDIVMDMGSPDSASSEDALDSVSVASSISYDFGDLPATPTTPSLEKQSSVDSYTDEKFRADVQLMRSRWAPHEPFPNTREWTLEEKAAELLRMSPCTKYSVDDLVNVNQLENPEDKVTMLIDVVAGIRVPFRWNFVDPKELFKSYTVVTNCKKEKPKKDKAGQLIPKRPMNAFMIWCQKCRTLMAHICPQLHNAIISKVLGAVWRRTTKEDKELYEAEKKKLMLFHKEEFPDYKYRPKKKPKKAPAKSPNANPALGTPASKKSKSKSKKKEKGQQSAPGGIGLTDTTQQIVHPVVRERLQVKIDPDFKRGMGKRSTAIDLADLPCYQQSQISPDCSVSSPSREESSVFDTPDASPENSPSETRTSPSPHYNEQSLSPHLSGGGGSIAFKFEPGMYNLPVENNNNVPLIMAGSGGVMTIKSEPGTLSSAYWHTQLIKSESVSDEEPVEALTIADLPVLGSDVLHQYLHLEANQEISKSEMSVYLNEAEQTLDNFSFQPACFWPSAVSIKVEDTTTDLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1F2</accession>
    <name>A0ABM0K1F2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Spartin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101849873</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106504.1">
        <property type="nucleotide sequence ID" value="XM_005106447.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005106505.1">
        <property type="nucleotide sequence ID" value="XM_005106448.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827801.1">
        <property type="nucleotide sequence ID" value="XM_035971908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849873"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="1">
        <location>
            <begin position="181"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827801.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44265" checksum="D6B63D3F4EBDA8F3" modified="2025-10-08" version="1">MDEELMLHRDHNIIISAAEVSEDRMSHRTEIFRIHYGVEIIYISPEGVVSAPSCPSSLVIVSLTRADEGHTQRKGTASVFLQVGDWMYPLVAGSTPALRTVDGAYLFPDNNTKQPGSVVCLKLPERLAERKRSRFERLIESFTALELQRDHSRHNRQGHKNPPQYGTCKLSEIKASSNSDNIVTGAEWIAWGIEKTAEKVGDLIRVGSEKLREQIPPESTECNVDPGMQMAMAVARKTAEGVADFTGFMVAALGEATMFVGRQLAPHVRRQGEKYLPEHMSRTDPWTGKSELDDLAEKTASGIKGFCTVYAALDSAARSMGRSLANETVQVMQHKYGAQVGQLTENAVYTAGSALQCVYNRKCLGAKAVAKRVARDTGKAVVEDINKSPQHTSSYCGSFYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1R0</accession>
    <name>A0ABM0K1R0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101854523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005106696.1">
        <property type="nucleotide sequence ID" value="XM_005106639.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012942580.1">
        <property type="nucleotide sequence ID" value="XM_013087126.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854523"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF10">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="171"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="390"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005106696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012942580.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="62679" checksum="66481B91A02A4883" modified="2025-10-08" version="1">MMASSLLTSRRGVQTLLPSRPCLGLYFILICIDAVFASEELGSFDYPESMSTMPAPVAQNALTRDSFKPQHVHISFGDSIQEINIVWATQQVCKPKVQYGSHPWGLELTVVGKSIQFVEYNEQGLQNVHRVRLKDLLALTTYFYRVFCNDHQVGPFYFQTPQAGNEWSPDFLLFGDLGIHSQSIPSLVAAAMSGNYTAVFHAGDIAYDMKHWDGLVGDYFMKLIEPLASTIPYLTCPGNHEIDFDSFVHYRYRFSMPNTDWPIPQDKMWYSIDIGPVHLISYSSEVFFTNYGNFEKAQRDWLVKDLKAANANRLMTPWIVAIGHRPMYCSTHIGDDCAKVDSLVRQGFEEIFRNSKVDLVIQAHEHNYERLWPMYQGNVTQHSYANPDVPVQIITGAGGSREGADVFDESERPDWSAFRLDNSSLNSYGRLLVVNSTHVLWEQRSALDHTTLDSIWVRKDRNFSSPQNQMKEIDSQSDLASRDSVFASRLLTIGLSVAGLLAVVVFVLVVRVLVKRRRKRANARLWERNTVNFPHMKTLVLNYDSDDEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1Z3</accession>
    <name>A0ABM0K1Z3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Uncharacterized protein LOC101848541</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9" type="primary">LOC101848541</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106848.1">
        <property type="nucleotide sequence ID" value="XM_005106791.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005106849.1">
        <property type="nucleotide sequence ID" value="XM_005106792.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005106850.1">
        <property type="nucleotide sequence ID" value="XM_005106793.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005106851.1">
        <property type="nucleotide sequence ID" value="XM_005106794.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848541"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2127"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2172"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="763"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="877"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="954"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1222"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1300"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1448"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1524"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1704"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1884"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1949"/>
            <end position="1970"/>
        </location>
    </feature>
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        <location>
            <begin position="1998"/>
            <end position="2068"/>
        </location>
    </feature>
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        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="497"/>
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    </feature>
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        <location>
            <begin position="989"/>
            <end position="1010"/>
        </location>
    </feature>
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        <location>
            <begin position="1244"/>
            <end position="1285"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1448"/>
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    </feature>
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        <location>
            <begin position="1475"/>
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    </feature>
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        <location>
            <begin position="1537"/>
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            <begin position="1583"/>
            <end position="1598"/>
        </location>
    </feature>
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        <location>
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            <end position="1637"/>
        </location>
    </feature>
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        <location>
            <begin position="1704"/>
            <end position="1745"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1746"/>
            <end position="1774"/>
        </location>
    </feature>
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        <location>
            <begin position="1885"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1913"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2001"/>
            <end position="2013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005106848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005106849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005106850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005106851.1"/>
        </source>
    </evidence>
    <sequence length="2343" mass="252068" checksum="12143FB8F534E34C" modified="2025-10-08" version="1">MTSPPPHLGMSEERVSDSLQEEVAQILTRNFQHIMGGGNDCLPPGNSDINDMVDEDDGSFDFMKLSITDDEAFPERISGVVGEMAQMASGGHHHHNGEECGEDTSLESASGSTRQETHTGQGATPTRASESQHNGTEKTEEGTAHLKYDKACVNSKARDSQDKDNLTKCCKEMRNIAKENGEGPDVIPTGSLLLNDLNNSRKPATGRTDGGLVGLSGREEMENITAAPSADSNQSLASNVKCQTSGGVDDATGTMSWSGQEQLVEAGNNASLTEGNLSPDTGHDARSGVIMTSYPSVDGSCSISADGEGEEEAQKALFDEAEFELEEEDFKSMLSLDCSERNDVLSLNITEEEGDRVLTDRGPSGNRPVGRPKRSPAPRRPMVPCPIQPKQPAATTVVNSIVTTTASAIIMPPGNSRNSNSPSFPFPKGHVLPLDGGGATVVGKYPVRFVHGPNGPRVEVDAKNMIPSAVAMAADASSSPESEVEKDRVVASPKETEQIPSPVPSSAHNMSISAASPCSIQIDGPSLPSTPSQFLLHVEGHPCWPPGRRDAPSSVSEDVLSIAVTTSSNTSFAHLHPAQGQFQQTVPLTVHQADPTQNLRQNDFLLYDGQQNLEILQHHGGQSSQTGFVNDSVSSEHSQLLPDDLANLGRLVGSPPELMSPMSNVRQVSGSMGIHSDPVVVETQRGRYVDRQGRVEVSQGVFPQTVSTPGMYLTSQAAPRLTTAPVAVSQYVYLPDSRFHLSTTSTTTTAAAAACGHSTSGPVHGHVWNQGESHSAQPGSRHPQLVLQQRPPTEESGDSRGLYAVRSGQNVVIHQRPATGSAWQHGAQGAGSSSRDSRDLLQQMYDSIPSSASKVRSGADLSMEQMYRVPFPCPSDMLPAPGSSRSSTVKPAGRVAPINVPVQPKQDRTARWVDSNLYHQPDLDEGISDPSDHSLLDSPLEMTGIFGQKLLVIQDRSDPKPSTTSKQRPPRVAANSSSRRNAEGESRKAATTSSTTSSSKKNSPATTNSSQAYKKSSNANVKLPQANLKSSQSVHGVDAGSAVGPSAALPFCSGGASSSYSSQVDQVRRNVCPEDKIKTNMFPVLQQTSASASLTEEQRIADIKRALEQPLSANSSEHQMLSIKPEETEFFSINSEELVNLLAFPSIPGAGTIEESASGVVQVNRDSFPFDIYITPSMKASLEGKQQMKQETSLEKYLRPHLAPANKCLEPLGAHTLAERKISTASNSSSQEEDRQKAVKRKQAQSSEMMTSSSDRQSKTVPLSSSAQTPNATGFRTSGPTLNSQVQRQLRYHLALNSLSTQPSGREEVTPPEAAPSGPLQVQGTGLLPQSQLVASPDHHVTHKASTSSGYPVTSQSLVEKAKNPKNEEVAGSSVAAPFCHYRMGDGPEASPQFSEATVLGQDAKGRFIVQAPRASLPPSQFQYFLPQHSRPHQSQPDYLLSQYTQPKFSQQAQPRPTQIQHTQPQHAQSEPTHPQFTSQSQFTQPQLQSCQWQHIYPGTQQLDLAPALDHYSQTGPTVAVVQSTHPAGGWRPHRQSSSSTTNTSTATASDDNNFKVPSVKPRPYPTTSSGAQSGKFMGDRFPSTQSHMSIGGTSDVSMRSGDSLPHLEPAPQSSRHHSMGQEPSLTTSDMSISVEETANPPPDSYTQQPGNVNYVVCSADGMLFVGQSHYQTAGNNMKYVPLETQDSPSDLIHRLHPQQVQYQTHISQQMQDQTGSQVQLPSSEQSYPQFPVQTELRTQLPSQTQVPVPSQRRSRQQSPLPRSQQRSQLSKSQVQKRLEVERWLLQQDPVPQGAQFSSQAFPHDSHMAAGGADTPNIMMNYAAASQHSPSNVSAAAHNRGSNLVFCHASPSGVSTVPQTAQGYHMARELPSQVNAVPTFLPPTKSAQRVQSGNPPYLGLSSPGQHPSRALTLHQQHPGNHSNQPSLPCPATQSLAPVELLRLEAPVWPNDQGSSTLPDFLPDQNRASSPSDLELEQFMLADSFPPLDLKDDPQSLFLQERGSSSTPSISNQKSKGKNPSPPKDSKNGIASNSTSSEVRKAVGAKSSCEERDMSLGSGSEKGHSRGAGDLSVEKISLESSSVEIPSFEKDDDGETYVHWLCDMPQLQRVKVASLPGFHDALDTLSNNQETALFVAVRRGNLEVVKLLLSHGADPNILCSSPGSNANLRSETVRQTVLHEAAETGHADILKELLLKDGVYLDAPRPGSGFTPLMTALHVHAQQNRDKIIWMLIHNRCSLTAKDNLQGMTPLMFAIKTRDVHLVEEMLKAVGAANARGLVTHRARAGQTCLHFVAQLRTESAMKQNLMRMIIHAGGDPSAQNDEGETAKDWSKADMTKVLQDLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2X7</accession>
    <name>A0ABM0K2X7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005107526.1">
        <property type="nucleotide sequence ID" value="XM_005107469.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850362"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="8">
        <location>
            <begin position="435"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="756"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="854"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="905"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="788"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="953"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="983"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005107526.1"/>
        </source>
    </evidence>
    <sequence length="1044" mass="112899" checksum="6E2DCFB4369D2991" modified="2025-10-08" version="1">METQSANQGDGYKEKPQEGGGGSSSQQTQTRSPRNRSSSLGNENKNQNDSSVGSAVVNKDQVQQSGEPNTADAVVSFVKPNTSEYNKNIPALPKHSGAMSEDESIQEDRDYESEPTPSQRGDSQKRFKSKSLWTSQGKTVYPKSRAVNKEIRELRRNNALLEKNLKIDGLPEPPKLRKRRFSVGSGTGRPHEKDLGHKRKRLGSVDFRPRKDHMPKWELLGGDAGDPLNLNGLAHSEEGRLLNMKTPESSPLPTPEFRKLVYVRVPPNIEDPLNLEGKHDQRVLDKMLDATIKKRHRSKKKHEKQNSGKADGDMQSETVAETTVCSNVSYESMESSIDTTPVVQDGDKSRLPISESGPAQNSSEITTPTKPGPSASRRSRSISMSPERKFKRQISGGKGRCATQNEPKKFPEKPMFIYGNYNRYYGYRNKDHAPDPRLQHFSPSWFQGKDVLDIGCNVGHITLALAEQFRPNKILGIDIDGKLIRAARQNIRHMLSLRRKDSSKYPAVFELTKGPLEAHPLMGTSDQFPNNVLFLQGNYVPASEEILELQKEEYDTILALSITKWIHLNNGDHGVKLFFRKIFRQLRPGGRLILEPQPWSTYRKRAKLTPDMFNHYLSIKLKPEGFKHYLLSIGFVKCEVIAVPVAKAKGFRRPLIVFTKPDNKQSYSSLDVEVAKSICTACGSHDPSSCVHEFTGIRRGAYASYMYDHVNYPRMSSDHYYDPSTHRGASHGNSIEAEYAYAMGCGPAGVYGGDPFPMPWQRPASGGSRATDSPASHGRSTRAENGERSSGSGSSSSRSQSASERSYSSSYTSGSGSASSRTTASSEYSPLHNGPNGDIAQEVLWEDAVLNADMGGEADGDLEGGGDGDGYEGQVVVGPGGDVQDLNVQNDADMQDVNVQNAAVVQDGNVQNEVAGAEWMANADPGQPAEGGGEGGNQPAENVHPGNDDPSVNGNGLNASASSGGNNDDANGNGGLDTSSSSSGGGGDNGGGANGNGLNTSGSSNHDGANGNGLDTTSSSSGDPVGNNNNNGNDSMEMESSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K415</accession>
    <name>A0ABM0K415_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable G-protein coupled receptor AH9.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101860124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108250.1">
        <property type="nucleotide sequence ID" value="XM_005108193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860124"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="98"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108250.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44629" checksum="ED2707D40B2C54E5" modified="2025-10-08" version="1">MGKVRRNPRLFEVHPLITQFSRIISNEDHAKVEEVTHMLWTLVVLGAVTPCVTDVTITRPHPEGEASRGGLITDDQLTEALVIYSVLICSFEITGLVFNTFNLIVFVQMGVSDPVNVCFFALAVSDHCLLATGLLAQIAYNDIGSMPRKLSVNSLHMTMILLFYAHMFLDISILISTFISLQRCCCVAWPLKFKSVFTTKRSLLVIICIHLYALASYFPLFLKQTLHSAPDLLRNSTTWIMTFSKERSRLVSIIDILNQVSLCIITQVVVLICLGILTTSLRSASKFRKSARSEQTESKTISRKEDQVVKTVTLLSVVFVVTYTPAVMLALIQIFVPEFDTYKRLNNLYFILHNANDLFENSSAVLNFLVYLSTSTRFRKTFWVLLHLDNKQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K488</accession>
    <name>A0ABM0K488_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Uncharacterized protein LOC101848073</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14" type="primary">LOC101848073</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108373.1">
        <property type="nucleotide sequence ID" value="XM_005108316.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108374.1">
        <property type="nucleotide sequence ID" value="XM_005108317.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108375.1">
        <property type="nucleotide sequence ID" value="XM_005108318.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943508.1">
        <property type="nucleotide sequence ID" value="XM_013088054.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848073"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="797"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="966"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1058"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1086"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1149"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1177"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1264"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1292"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1320"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="376"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1339"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1339"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1362"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005108373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005108374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005108375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012943508.1"/>
        </source>
    </evidence>
    <sequence length="1536" mass="172297" checksum="E56A0C2DE7BCCCAB" modified="2025-10-08" version="1">MAEAGVRKSGRIKVRKTSYLEDDFEYDFCDIDLGITTIGNSNHPQSKSSGRAKAKSKLKTTTPVVIKKSKKKDNVVSDKVDNRKSVKKAKRVSTDIREVTSAKQTENENATDDLVDSALLLDTNNLSCPLCGQQVSGEAGLEAHIEEHRSKDTGLGGCYVCDICHKVSVDTASYNRHMRTHTGERPFKCDLCDKTFTESCSLKRHQKSHQEERPYVCDICFKSFRDSTSYGRHQKTHLEQPRMYQCLKCEKSFTEKHGLKRHERTHTGLRPFECSVCEKTFSEIGSFRRHQKIHSGVRNFHCWRCKRSFLEKQSLMRHMKNVCGFGGYVDSGDRSFSDPTQDSLKSDLDLRELSQVSVDSLNAQLQAAMKYEMDLGKSNGSDKTDETTVKSEPAVVNSSSTLVSKKADKLTSGQLDKAGKPSPSLGSLMKKDPNLYDSISEIVESIDSYEKMLNLCGDSGQKELDAALTREPALVPDNLLCFECGELLVDGENFKKEGKNFSSSTNSFKCMSCEEEEEFGEPPVLTAEISGVDNSPRSERGEMDKCRDEEESEKLLTSITPGLQSAGSSGMNMFGSAESLQHLRERLRSQHGVYFVGDVYNTAGYKDDDSCTSDATGATCTTGSRSNSTDSDMCKKDASFLNAPLPQKVESFHKNFAFSGGDSGNYEQSGDSAGSQNYHHDLQKKNGNTLMSGSSEMNNTAVDTSLASVNSIYTSQVHQQNIWSSVPRLEYEADDPSIPSVFPCHLCTKVFATSAFLSQHLDLHKKSPHKCMVCGKSFTNAPSLKRHMLTHTGEKPYACPKCNKHFRDPSNLCKHKKNCFAELQDIPKTPSLTSLESLASLTVASPLPYFDMAPAVNNGAKDDVLSLADLTKEVSADKTNALSDNVPITFSYDDNNNNDNDEEEEDDQLTVSFSANLDSTFCNDVNSSTDNYISVTGGNVVPRGSGDLPGTESQPEPADTDTLVLVECEVCEKAFKDVQSLEMHMNYHNGDPDVTCIECGKSFADPHGLKRHLRIHAGVRPHVCEYCNRGYCDAWSLKKHKSRGCLLAEIQVPADFLYPCQQCTRVFGDQDCLQEHMKTHKGLLKYQCDICNKKFSEVFNLKRHRRLHMAVCPGCDREFHDVQSLHQHQASECPANNGGVQLSSKQDGFPCPECGRVYSTKAYLERHKKFHSELKPHVCEICNKKFSEAFRLRRHMKVHKNDAPINTCDADLEVLNPQKLSNNHSELIEGGHFPVNMQKDTRAEIISDFNSKTQQQDGLQPSEFPCNLCNKVFQKKYLLVRHMNVHSQERPFSCDVCGRAYKDTSSLRRHLLVHQGIKDHICPVCGKDFFYSDSLKRHMNGKCGKSSKKRKSRKNSGKGKKNFTNNKVRKTNNNNTEDVLNNNSVLAVSASPAQNAWKRITVAYAPRVVKALLVPLVNNTYAVRHPLRSVSVGRWSCHKRHHCWLCDLKLGSRRELLLHARSHRHLKKFRCPRCFVRFRRKAYWKSHMAQHDGCFQAVVAPRCLSPDPVAPPVAEEVNKRPRRSIPRAQWSWISQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4C8</accession>
    <name>A0ABM0K4C8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101848384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108455.2">
        <property type="nucleotide sequence ID" value="XM_005108398.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848384"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF108">
        <property type="entry name" value="CLAUDIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005108455.2"/>
        </source>
    </evidence>
    <sequence length="292" mass="31986" checksum="176B8E65092B8106" modified="2025-10-08" version="1">MDSKILTLLGIGLLSVAVLVHVICLSMPHYASVNIGETIVSGMAKFGEQKRASFPGKRGWEDVPFDRQSLSVDQPRRGVRDSGQSWAQNVFEKLAKNPSELLKYLHIVGYFGLWKLCAEFDIVQTNLQALICTVFDSDTNFEINLPEIPHVKSVAPGWLKASQAFAIVGLLAMVAGGALAVLSIVKESKGGRLKFLHLFTLGACALGGCAVLLSNIIFASKFWQIWADGNNVPKRMEEMPPVLKDMLNDMFTLDWAFGLDVTAAVLSLVAGVVLFIAGRRMTQKYVEVNLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K606</accession>
    <name>A0ABM0K606_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Headcase protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109542.1">
        <property type="nucleotide sequence ID" value="XM_005109485.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863383"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026066">
        <property type="entry name" value="Headcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031947">
        <property type="entry name" value="Headcase_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054537">
        <property type="entry name" value="HECA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425">
        <property type="entry name" value="HEADCASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425:SF3">
        <property type="entry name" value="HEADCASE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16002">
        <property type="entry name" value="Headcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15353">
        <property type="entry name" value="HECA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Headcase N-terminal" evidence="2">
        <location>
            <begin position="50"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Headcase middle" evidence="3">
        <location>
            <begin position="353"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109542.1"/>
        </source>
    </evidence>
    <sequence length="555" mass="62077" checksum="6C8706298CE7F780" modified="2025-10-08" version="1">MPNTKHHKGHRNVHEDVHNNNVNGQHVNFMRDREDHHNNGDHAEARFQPCCVPAGCSDDPIDPTDPMDAVRVVCNNENCKEGNWMHKDCFIEWEQSVLSFLRSCGRARSWSEKQRLQNLWTKKGYDLAYKACDCKCGRGHLRKDLDYFPAPMNDNARKARKNKKKNDKPMPVVSTNHKSSHNNHNNAVANQHQLDNHGHHNQPQNLDNASKIGKKTIQPTTPTVIIAKRRGSDNTINNNSAHQSTGSTGPTVLGNSKNRSRNNSTSQSENGTDSEVLDNVALNGQGTANTQMTNPFPRLRTNSVSSTGSVGSQASSSGSIPSSAGSLSPLSSSPTGGNIYFKNKKGDIFDPAQPGIFRHRHDLSAFNALPRYKQNPYNIHIDDVQEDEDTRNFVLSNLTTKRMTALRCVLCKVQLPVFDKFPLVDGTLFLSPQAYDQYVVQMIWEGRIQFLNSVCIGCLEGAAEAKCSACKKPWDGSSLVVGTLYTYDIFAAMPCCQKRLTCKHCRRAVIDISNGLDYFSQYSRMIICPYCKANDYHFIKSISETYSIKESICHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6B7</accession>
    <name>A0ABM0K6B7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dentin sialophosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109748.3">
        <property type="nucleotide sequence ID" value="XM_005109691.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851534"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005109748.3"/>
        </source>
    </evidence>
    <sequence length="891" mass="97659" checksum="4F83EE8561D60130" modified="2025-10-08" version="1">MDDMTQSETISPSSVESTDGNSINSDDTDKHYAGVSTHSLSNDNDNGSRPSSFNKVDFDMSCACRDDNSSVDRNNKIDKDDVGMCICSHSKDDNTDNSSSSSISKSGVEMSMSSDDNGKQVEVGICSHQGDVHICTSKDSNDNNDSKNANISSQVKNDGFVDQVVLPNWPSSEATPTLAKQNPEAARPCLNDFHSASGVKVTLNNEDLSNEKVDNVEVEVAMETVKKVSNEKTNPMANGMEDKIVAEKVGVIPNNMANELKGEMLNEPADEKSDKLEDEMAEKLLYEMVDELVGENADEKVDKLAKEIADKLADEMADKLADENANKLADEMADNLADESADKLADEMADNLADESADKLADNIADESADKLADEMVDNLIDDMTNKTGDKKTDTSKSTKTEKLFAEFMSRQDRCAGQDSGSVQGMRRVQSNLNPSTATQTGPANSTAVRRICSDSKLAGDSYNVPQELPRKSSAPAGELHVRFFLGVAGESDGAVPAQTLLRSGNNVRRDRTRLQNSRTRSHSDSSDTYAQEGAGELSQEDQHHSSSRFSRFKEIFRSSIKRKKKKNSEAVGNADGSGCDGVVIAAGKDCNKQRVVLNSERTSSSMRGSGALGAPGSESCAGGRAMTTSGEEKDVRNKPVTSDPGTDSNDDGEFPTTFEAEHGQSQDQSQAEDYDPGNIFEGFDLCQGYRKGVDQDQGHGGHSTAGWQGGPLRFSFRRTQSTKSRRLKPLFEEEDGEEEIASSLAHSAADASVLAQTSRWSIKRRRQRLANAYDHQNHRHHHHRSSSCRSTSSRSSQNNNDHDDDNDNDDDDDCDDNDDCYNGHGRLRHHHHPYYDHHHPNKVRSINDRHTRSNSFKSLKNHVSSFLDHLPSLHGSPSSHRRFSRGQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6R2</accession>
    <name>A0ABM0K6R2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox protein six1a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005110051.2">
        <property type="nucleotide sequence ID" value="XM_005109994.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862686"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="187"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110051.2"/>
        </source>
    </evidence>
    <sequence length="360" mass="39602" checksum="00A305C17077DCE3" modified="2025-10-08" version="1">MMDPYSYSAGNFHRLPPFPSTGFVSKADVFRPDNGASVRPFPSVPMLHDQTGTNVGGSPSGAGGSMLPSFGFTQEQVACVCEVLQQGGNIDRLARFLWSLPACEHLHKNESVLKAKAVVAFHRGNFKELYKILENNQFSPHNHPKLQALWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRTILREWYSHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKDREHPGMGGGPGMPPDPNSPHSDIKEEHSPDSLAGHSKLDESPPHPSAIYADLQKASSMAAASAGSMMAAAHGMMASHGNPVGVPHMGHHLSNAAAANNPGVNPMLQEYQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7Y8</accession>
    <name>A0ABM0K7Y8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PiggyBac transposable element-derived protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110942.1">
        <property type="nucleotide sequence ID" value="XM_005110885.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860535"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="214"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110942.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="79687" checksum="3DDFBA53112C9945" modified="2025-10-08" version="1">MASSRGKRVASSEVLDRYFADGSGDEGDFDDAGGDLDDHYNDSDIFDDDDDDDDSFVENLEAGINESSKSASSSSLSVSGSGANRTNDDVISGRGDSCSVKTEACACTVKTEETEWGIKTEDGECSVSTVPEIGLSDDEEMSDDDFVEPDEYVYRQDDTDSQMDLTSHQDQASHSDSDSEDQDEDWVHDTQNFPKVPPFSGQPGLKINLSDDSTAREVYKLIITDDVINKWTVETNRYARETIGLKKKAAANLSDRSRFKSWKPVTSQEMRRFLAVCLHMGLVHKPTLNHYWSLHPALHSSFCAKVMSRERFLSILAFLHVSNNADYIPYGEKNHDPIHKIRPFVEHLNHTFMSLYEPHRELCLSESVCPFKGRSRFKVFMKNKPAKWGFKLIQVCESKSGYVQRFEMYCADKRVSNKPVEVVDRLLEPLKDKGHHLYLDKAYCCPQLWDRLHRRRTMMCGACRKSCAGMPAAWFQHRQSPGQLDYRRKGQLVVTRWTDRREVVTLSTIHLPQLQGTHGRFGAKDKPVSVTDHAKHTAGLARSDQVVSFFPMKRKSQKWWKKLFFHLLTLVSVQTAILLNKHRRSKDRKALTLSTVVKEIVLSLVDQQQQTLETTASDTASLPNDRLSGKHFPSWCPQTPGRTAHSRRVCKVCMVKARQSGQTAAQSKCRRRLSRFWCASCKVGLCLEGCFEAFHTKVDFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8I8</accession>
    <name>A0ABM0K8I8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101864185 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111351.1">
        <property type="nucleotide sequence ID" value="XM_005111294.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864185"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111351.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="64514" checksum="4654B857EA0CEF42" modified="2025-10-08" version="1">MTTTDTQVMKETSSAGENHSTIIQPDTLSQHSRISGGSSSPSQEGSVPSSPSSKSNKVGDSSVVLDMPPTARKPLVTKRKRVLIVGSGASGTAAAYALGKHPDKFDVQVWEKLSLPGGVATSEHIEGPGDLVINDGVQGGCPTYRNTLNLMSEFGFSGSPVHMMISFGKGPTAWTNYTKTDLIDRLKDEIKRFGRTLKIINKLEFFFIFIPISKVLKWFGYSDAFCYEMVFPLTALFFGTGNQTPNVSAAIVARVFLDDDLRLFDYDPECLLSQTPEMFAFPKLRDMYQTIMRKMETQYHANRAVASVIRRNGKVHVVDDADNEEVFDEIIFACDAETVLRVLKQPSYLEKKALGNVRYYNDVTLTHEDDEYMEKHYELHKDVDQYFIRTDPNDRSKLEMSFNLSNYQPHLKDTGRNIYQTIFLDDKIKDIWTIDEIDKSKVRFTRWWRQFSHTWKHFAFTVPLWRYVQGTKHTWYCGSYTLINTHEIGIISGFAAACRLGASYPFIEDKLAREQFEQYLLMIHGKPRRYGCNGATFLSILFAPLMFIFVGLALFVQFIMRCCGKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9N4</accession>
    <name>A0ABM0K9N4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme E2-17 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112255.1">
        <property type="nucleotide sequence ID" value="XM_005112198.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857461"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005112255.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16619" checksum="671D672AC50BD0E6" modified="2025-10-08" version="1">MATKRINKELQDLRRDPPAGCSAGPVGDDLYQWEAMILGPPDSAYADGVFALSIHFPTDYPFKPPKITFTTKIYHPNIHANGSICLDILRSQWSPALTISKVLISITSLLTDPNAEDPLVPEIAKVYKTDRSKYEELAKEWTRKYALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB15</accession>
    <name>A0ABM0KB15_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101860473</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101860473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113278.1">
        <property type="nucleotide sequence ID" value="XM_005113221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860473"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="69"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005113278.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31439" checksum="FBB99BFECB24D901" modified="2025-10-08" version="1">MTSSVSEQAAPLISGEDLGIALIVTVVGLCGLFSLLGIVTNVTNLVVFAKLGFQDNINISLMGELITGLITAFITFERCLCIVLPLRVRTIISPGRTKRLVVSLFLLLFCLFLPCYYTNQLAWVFVPERNTSILKITRTPALEVVNQIISMTQGVLINTFSFVTVIICTTVLVVKLNKKTKWRKATAGKGSGGSGDLGLKEKKVAKTVTFIGAIFIVCSLYSTVVFFCLVIDTDLFVRGKNENLFLLANSISILLTTINSSVNMFVYLKMSSKYRAVFLQTFVWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBI0</accession>
    <name>A0ABM0KBI0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101862926</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101862926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113585.2">
        <property type="nucleotide sequence ID" value="XM_005113528.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862926"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567:SF1">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005113585.2"/>
        </source>
    </evidence>
    <sequence length="151" mass="17674" checksum="4FCC88225CA1A9B8" modified="2025-10-08" version="1">MASSDQLKSLPSQRKLIWENYNEQKTQHWPARGRHILAHYDDEGIVVYQAFNKAIAEYAVKFQRFGGPAYRFERMSWIKTNFMWMMYRCGWTSKPNQEHVLAIRISRAAFEDILSKALTMEKQKEQSVSADKLQVRLQWDPDHNPQGGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUX1</accession>
    <name>A0ABM0ZUX1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">High-affinity choline transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101852156</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934956.1">
        <property type="nucleotide sequence ID" value="XM_013079502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852156"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012934956.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="55711" checksum="DB80F456843AB740" modified="2025-10-08" version="1">MLADRSIGIFVGCFTMTATWVGGGYINGTAEFVAWDGFVWCQAPIGYALSLVFGGLFFAEKMRSSGFTTMLDPFHWKYGDIMNCLLYLPALMGDVFWSGAILAALGATLKVIMELDLEIAIIVSAAIALLYTLLGGLYSVAYTDVIQLICMFIGLWLTIPFAMTHEAVDSITTNSSDKWLGSLEGSYAANYIDYYLLLICGGIPWQVYWQRALSAKSVQGAQMLSFLGAIGCLVMAVPAVLVGAVSASTNWNATSYGHPALLEEDRTLTLALVIRHLCPPAVTFIGLGAVSAAVMSSTDSSVLSSSSMFARNVFGVIYARIYGTKPSDSVQVWVMRGAQVVITILACLMAISVKSVYGLWLLCSDLVFVTIFPQLICVMYLKDSNAYGSLASFVLGLVFRLLGGEKSLDLPAAIEYPWFTDGTQLFPFRTLSMIVSLVTLILVSYLAKFLFEGEVLPLSLDVYGCFQHLDKKASYVDQSSEVTEKPATLRESVRHRDVTEGGEKKPVIITQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVJ3</accession>
    <name>A0ABM0ZVJ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101854556</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935413.1">
        <property type="nucleotide sequence ID" value="XM_013079959.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854556"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF108">
        <property type="entry name" value="CLAUDIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012935413.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24285" checksum="1A8BEA2ED3F6835F" modified="2025-10-08" version="1">MGESCSTRLSRVLFRIGQILIAMGFVCYVVAMVTTYWVERPAIDYAAQKINPNETIVTRNYGIFRACRQSASRSSNGRTRGNCGSLSANLNFIDSVTTVYIQFVMVLACILYIVGISMEVVQFLPIQKFRNFLAQNRVVELFCAIAAVLVLKGMVIFAGEIRSKAERVPGQEDEQTGWSFIVAMIGLVQCVFGVVLTTMFRELPIRHSGEKGGSWLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVT4</accession>
    <name>A0ABM0ZVT4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Proton myo-inositol cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101852836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935574.1">
        <property type="nucleotide sequence ID" value="XM_013080120.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852836"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17360">
        <property type="entry name" value="MFS_HMIT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="312"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012935574.1"/>
        </source>
    </evidence>
    <sequence length="863" mass="92852" checksum="764C648B40EF7400" modified="2025-10-08" version="1">MGDKIPLIHSGGQKPSLLSLSRKANKETEKPEDDNQGQGQSYGTYDGGTDPGGAASGVTTRQQHILSPPPTTNSPRQSPPAGDNSQEDSSSGLSPQTVPTSATVSNVPPSTTDLVQSTPSSTTNSSVLPPSVSEASHPPDSTPQNNYNNNNNNNNNNNNTFLQGNEPVSDSDAIVQVCRRPDQRKAPKDLNNDRKNFKQSPKAQRASGASQGDTPNTHNQSCAPNSLFGVFIRTLNKRLFSGSDRSHNSLNPTGSDGECTSSERDPLYPDRMEQKNGHYLDTGLDGGKGEANGYSGKKDETPVPTPFFVYYLACFATIGGLLFGYDTGIVSGSMLLIEDYFNLSTFWKELIVSGTVGAAAIFALFAGFTCDVLGRKITIMMASVVFVIGAVIMGAANSKEMLLGGRFVVGIGIGFASMTVPVYVAEAAPPAIRGRLVTLNQLFITIGILISSIVAGAFSSMKETGWRYMLGLAGVPGIIQFIGFLYLPESPRWLVSKGKDEKAKAVLQRIRGRADVEEEIQEIKQAVEDDQKQSGFVLGRVMRTPHVRKALFVGSGLQIFQQLCGINTVIYYSATILRMAGFPPEAAIWLVLVPNSINFLSTIAGVALVERLGRKKLTVASFGGVIIALVVLAAGFQLSANFSPSLDKNITEMSVNGNPFDDECFNASYSSCEQCIEHKHCGFCFKDSGDFGSCLKADPDDEDAGAITGRCNETVMGTQGVDWSHGYCPTDFNWMAVVGLALFVLAFAPGLGPMPWTINSEIYPLWARSTCNSIATGFNWICNLVVSLFFLTLTETITKYGAFWLFGGVCFLGMLFTIAFVPETKNKSLEEVERLFMGSKAKSSVYEREIEASTPKESSVATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWG3</accession>
    <name>A0ABM0ZWG3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hepatic lectin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935938.1">
        <property type="nucleotide sequence ID" value="XM_013080484.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011313"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935938.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9876" checksum="27A88350F319D8D0" modified="2025-10-08" version="1">MFPGSYLIGLTDIDEEGRWRWDVDGTVMTCEMWDTLWRGDEPNGGNRNEDCVASANTGPNASTTIKFLDIPCSRWAPLKFICEKYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXL6</accession>
    <name>A0ABM0ZXL6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Equilibrative nucleoside transporter 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101859926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936591.1">
        <property type="nucleotide sequence ID" value="XM_013081137.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859926"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012936591.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50056" checksum="B5092D66FB31BE36" modified="2025-10-08" version="1">MAYEQVYEEEEEEEDPEETPLIQSGSGPKAPPDRRYAVFLIFGFLGLSSLLPWNFFITAKKYFDYKFRNTSLPSNVSFDGKGHTTDMQVVFESYLSIVSNGSNLLFMIITLLLVRSISVKVRIVVSTVLMITIFVITTSLVEVDTDSWQQVFFIITLVMAAFMSGVQSVLTGSVLGLSALFPAIYSQSAMIGQAAGGTFSAVVSILTHATGGDPITSALIYFLIASVVTGLALVAYLSLYAQKFSRFYMIDQVYIASKINEDIPSYHDIVGRKEYLGAILKKTWMYCVSICLVFMVTLSVFPAVCSLIKSYSHEGNAWTDTYFTPVVCFLLFNVGDFLGRLVTFVFKFPGPHRPQLMLFMCILRIGFIPLLMFCNAQPRYHMPVVFDNDAYPVVLILFMGLTNGYLSTLCMSFGPIDVPDEHAEGTGMMLALAMTMGLAAGSGLSFLCVYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYH8</accession>
    <name>A0ABM0ZYH8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein kinase ATR</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101856065</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012937158.1">
        <property type="nucleotide sequence ID" value="XM_013081704.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856065"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056803">
        <property type="entry name" value="ATR-like_N-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25032">
        <property type="entry name" value="N-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="15">
        <location>
            <begin position="1614"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="14">
        <location>
            <begin position="2288"/>
            <end position="2605"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="16">
        <location>
            <begin position="2603"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012937158.1"/>
        </source>
    </evidence>
    <sequence length="2635" mass="299070" checksum="068267E3C84B80C3" modified="2025-10-08" version="1">MPNVEQPTILFLQRWNSADGPRDFSIHSYRNTIADLVDNFLTDLDDVVKSLETDGNASGSLRSLTMCLEFLRENGEIFHHISSESSTSENLRVLQEENTSQAFCYWFLRHLLRLLGHSECGEVHAVTIKLVIHILQAIKLRHVFVFRQHVTELVKTCGELVALSDRLYAGEQTVALTSFYSDIDLAQQSLRSLSEGSKDELLCENKIKKVDVTISDPKRCELLQVNIVKIFNGMLLDVCQIAGSSVDVIWGCLFCNVENGDVELKAASLECLASLLSIRGLPLISATDYFLQCIIAFWELMCSGCSVLDNSEKEILERSGSEMLSSLIHSDTRGLLPSRQTFFRQFTEKVCMGGLDNLLTVQSKRTLVSMFVHLLRGIPSSDLFDRLNRPATEILISHAVGLMASASSCEYLIPLLYELTLMEVGCGSSQRDTDYSSSSQDSATQRRTSELGSLAHSKKKADTSLSLKRTSFHMYDRILEKETELTSDRGCPTMLEIKCHLTVVEVGARCLQALHARGFAISDKTHHPFLKEFIINSALDCWIRYLKSVASNSDSLSSFIEKFSVILRSIEDILLVQEFHPMPMMVLQELSWILTLPWLANDFSWKDLKPLKPKEVGNICASLVEKLDVETTCRCLSIMALLPKETAVSWRAHIISQAMNDNNETILKTAVRCFPVLLHQLGPKSGHLVDQLFVPLLNHESVTVCQELAERFGEALLAKANVTKLRRCAWNAGQLDCADVRVEVAASNTGKVLKLEEVTPFFSLLTRSGDFRLIALRSLTKVLPFVDLSGSETLKKSTVASCLKLVEDDARDIRLECCSLIPCLVTAEARLPVGKPSVMDNQILQHLERLCSKTHLGRREKAFLETALTALGQFGRVVEGSLLQSVVVRLLEHRLSRQLNIASVAFTQLEQIAAHKKESLQQIYVRFKGAICKFMVEEIYVDQQNTGGTNGKSILMNIARTLEADDLKAFLQGNEKFMVPFLVSKGSPESTKLLKLIAVLQSSSSSRRSLLINNTKYIFSYLVRFCQKEEMEKAFLYLQTETDFSLGNLLRLDFQRVHNELLLHLSTHHHQVFSGLKTLATYDEKCKSAEEIQTSEQMALYLEPRLLGVLAFFDTQLMNSNITMGDKELALKSVISIIQLMGSKHISTIRHKVMNTLRLGLQFTEKPFTEISCKAWNCFVRSLELPLLGVMMSQIIATLLPLLQCLPEQVAQIFDYMIVENRAVLSKHFHEIYFLPDIPELTDAKKVLTQHGDSFESDRDLRLLLAHCIKGVQHESLDVREHALSKLRNILRDKQMEIKNYLLNNEQAEPVISHLVSALLNGCRDSDSRTQILYGHCLGELGAIDPGRLELITNKPSVKLADFHASIDEDKFAFSLINIVVKAFLAATEPRVQDCAALALQELLQIYGISESGSTQGVSPHSRLWKMFPEQTQEILIPLFSSKYRLTVDTDYANYPKPLYGSERGKNFKDWVSNWTGYLSSKVKPGKARQVFTACSATKRHSMQVALHVLPHVVLQVLLDGSTTHVKQMFEELMEVLNYMQKPETRLESASNFHHLSAQTVFSILDYLTMWCNHRAQSLAATTTAAAAAKGINYEKDAGYQAVRRFLDKIPQELFAQACYNCKAYTRALRHFEVFITTTKDIQPHLDFMQRLYVSMDEPDGVLGVATVRMSQPTLMQQILMYESLGLQQDAQACCEIGIQMEPEEISHYHGLLRSLIDLAQPHNALVHTAGLLAERPRWTAELNTYRIEAALKLGSWDKLDEALKHEKQSSRSWPVLVGRVLKAAKEKRAADFIEQLDLARREQMGPLSAASMEIGSYHRGYENILRLHMISEIEQFFQVVSDFPEERRDEKDLDISSTQLLDSWQSRLQMAQSSFRSQEPILTLRRTLLSLVQSERDPSLDVQIGKWWLWSAKVARKAGYLQSAYGCLLQANSYNLPDFFLEKAKWLREKGEPEAAISCLEKGITEHFGGMTQPGQIEALNRPLKEVYAKSLLLYAKYNEEASNLETNSIVKQYKEVYEVCPEWEDGYFHLAKYYDRIMVTFLDDKERAEKQGEFVIHVVRFFGQSLKYGNEHIYQSMPRLLSLWLDSGTAVAEAERKDKGKVSSKLQTLRTVLNRINSNVQQLSQQLAPYQFFTAFPQLISRICHARVEVFQLLQDIIASLLLQYPQQALWMMMAVSKSSYLMRVKRCQEIFATAIGKQPDLNKFIQDCKKLTERLLELCEKDFGSNMTVSLSQMFKPLKRLLEGSNFSKILLPLQSAVTVNLPATVAEGLNHNPFPDDQIYIQGFEDTIEVLPSLQKPKKITMIGSDGKRYVMMCKPKDDLRKDCRLMEFNAIINKFLRRDAESRKRRLLIRTYTVTPLNEECGLIEWVNNTTGLRHILVKLYKEKGLYMSGKELKALMPSLHSSLETKMTIYKEKLLPRHPQMLPEWFMRTFPDPTSWYSARVSYARTAAVMSIVGYILGLGDRHGENILFDSHTGDCVHVDFNCLFNKGETFEWPERVPFRLTPNMTAALGPLGYEGLFRRACEMTLQVIRDQMDPLMSVLRPFIYDPLVEWSKPVKGQRSNASDSGEINNEQALNHVQNIEDRMRGILKTKAKPRCLPLSIKGHVNYLIQEATDEKNLCQMYIGWAAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYT4</accession>
    <name>A0ABM0ZYT4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Folliculin-interacting protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC101858179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FNIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937332.1">
        <property type="nucleotide sequence ID" value="XM_013081878.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937333.1">
        <property type="nucleotide sequence ID" value="XM_013081879.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825375.1">
        <property type="nucleotide sequence ID" value="XM_035969482.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858179"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037545">
        <property type="entry name" value="DENN_FNIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028086">
        <property type="entry name" value="FNIP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026156">
        <property type="entry name" value="FNIP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028085">
        <property type="entry name" value="FNIP_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14638">
        <property type="entry name" value="FNIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14637">
        <property type="entry name" value="FNIP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02073">
        <property type="entry name" value="FOLLICULNIP1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51836">
        <property type="entry name" value="DENN_FNIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FNIP1/2-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="891"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="891"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012937332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012937333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035825375.1"/>
        </source>
    </evidence>
    <sequence length="1162" mass="127628" checksum="65E34C42EB7CB86C" modified="2025-10-08" version="1">MRVFHPDVDRKMFFDIGHNYSTLKNNGLSLISKIFPSRKTVAPKLDKSKIRLVIYVDSDHGRMPYFDSNAIRPVDEVDKNVLRSAPKTMRAKGLYYSQHKEPPVPQQKQVPKFHFQRLGSDVKVLEEMMFGTVGMAYKGTSLKIHLLRSPPQLMVTKVFLPEKPRRESIGDTESDSNSLQGSSADFSSGEFSLPLRKSKEKYARSIPVDVPSREILSDYSTDDDSGLASFTSSGSLRTSFPSPSNNSASSYNSLHRRWMRAQTTTLDGHSRRQDSSLASEGTVARSRKKMLAIGILFGPHDEKDEESTMLFQSFFFSHFALIEGHVEKLRSVIEKAYFNSRSFLPVTMEALDTFRTNVYDLYMAPRLPEPVWLTMMSTTTYKTKLCEKFMQEFVSLVAKYDNKNCKFFVSTLLSAVLTQHLAWVATVTPAGGTPSKTYLDKHSAKWVDTLAKTHPYNPLWAQLGDLFGAIGLPLKISRTVVVGKKADVVRRFLYILSYFIRCSDIHENSDLDCLNNLLSQASLELSISPTASEKTVVDTSTLEGSSASPAATNHLLTSQTSVTSQTSVGSDGGHSIKSGSSGVEFPRRGSRWANTEGCSLVNESSAVCMCKCGRPVRLDGGPMASQGNNIASVGYQVAGDVVTVETGEGRGLAQLTANSDPSSRSSANSKCVSCGRTISSVCAFSKAQANSVEGGAICHAQKGSNIPRVSQTSVSNVPCASEAPVLSDMHVGVHPRLEQSDSLRADISAMLPPSSDLHAMSELQIFSPNSLPVCSMTSSKIIESPCRETVTNVLKAADTSSAISGNIFSSSGAEPILRSQSFSEGKIKSRLSQQLECEVVDLTPDSTKAKTVDVRKLFLSEGSNSMFEEYFEPGVEVKTIDDVSEVERALLSSTGSSTSRMSAEGKKELETPKPSVSRQNSQDIKSHATRPTSLAHRSRSITPTELSRRRHLSSTGSIDYEMFDPVNHCAEIKMPEPLTDSNQWNIKAFDRNFGRSLLAGHSSHYMSDFVLHGTSDTNFKSRLLHDLQMTVQHSILDEPIDEAVCVIADTDNWTVEVASSKVVSICPSGCTTWASSQLVADLIESVVEICRLKMSPEFCLMHLEDRLQEIYFKSLMLSEYLRGTRAYNQRELTSMLGFESSDMPLLLAIAGTHTPSLALGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ40</accession>
    <name>A0ABM0ZZ40_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC101863813</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005097577.1">
        <property type="nucleotide sequence ID" value="XM_005097520.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937495.1">
        <property type="nucleotide sequence ID" value="XM_013082041.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863813"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05040">
        <property type="entry name" value="PTKc_Ack_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09539">
        <property type="entry name" value="SAM_TNK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14328">
        <property type="entry name" value="UBA_TNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.680.10">
        <property type="entry name" value="Cdc42-like binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015116">
        <property type="entry name" value="Cdc42-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037085">
        <property type="entry name" value="Cdc42-bd-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049587">
        <property type="entry name" value="TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09027">
        <property type="entry name" value="GTPase_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22931">
        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="122"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="385"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="1408"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="521"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="718"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="968"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1172"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1255"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="973"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1007"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1045"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1179"/>
            <end position="1195"/>
        </location>
    </feature>
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        <location>
            <begin position="1204"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
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        <location>
            <begin position="1277"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1301"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1345"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005097577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_012937495.1"/>
        </source>
    </evidence>
    <sequence length="1465" mass="159269" checksum="5701D0ADAB636AE4" modified="2025-10-08" version="1">MSSACKEEDEGSEWLVNLLNEIQLGQFYIKLRDDLQVTRLVHFDYVKTEDLEKIGMGKPAIRRLLDTVKKHKSIRKKGILDKILPGGKANPDKPSSGSGKLPHSPSEYGDMALTCLIDKKNVYVFNKLGNGSFGVVRKGEWVAPSGKKKEVAVKILRRDALAQPGAFEDFVKEVNAMHTLKHTNLIHLYGVVLSSPLMMVTELAPLGSLLDRLRDSSQQQLLISTLCEYAIQIAVGMSFLESKRFIHRDLACRNVLLKTAELLKIGDFGLMRALPSQTDHYVMSEQKKVPFAWCAPESLKSRQFSHASDVWMFGVTLWEMFTYGQEPWLGLNGSQILHRIDVEGERLTQPPHCPADIFPLMLQCWAHKPMDRPSFIALKDLLSEVLPENVKATQSFSEEGRLTLEEGDLVTVIGGRSDRFWWQGQNRRTAEIGSFPRSIVEVQRKLAGNDISVPLKNSFIHTGHGDAGGKNWGNPGQIDEVYLRNPMDPPDLHEEDHDLAGQLGSRNLFSQSQFNYNKLKNEATSDPRKSPPTGQKPSPKHQQRGKQPAPKRPPAPSVKKEKRGKNSLSVDTSGSSSLQEDVALIDLTTSPPDKGQQGRVNGNSGDLDIFDSLCSVTEEATHYRNIQLPAPLLGSGSSPDPFDVNARFCLNPAGQTAASGAWAENKTWGSTTSGSSTSATVSALTSISSYSTVSSSASSSSSSALTFSSSTTAASNLTSASSRSSASSSHHYGNSSSSAFAPFRNATSHYSRSEDSPGGHPTNGGLLYCEPPAEDAQYSTYSNGAQPSGRGDSYSVIEQSAHSSESNSGASTLHGLNFSSSSASFPAGYMGSPDKGRSISVDGAFQERLEQTVLKAAAQPPPQQTDSSSIGGNLFPARPHSQHAHVAVQGTQQLFPAGHHQSHHRTVPLSRNPFSQPGTGPDHHSVVRPSARASCSSDPGGKENIDKEKAEKAFDWLKDAVSSLAAQQKKEMNNQLKSCSRSHSLTDGGLPLYDDVPDESKEDLSGGKTSTSAAQQKINSAYSRSVSGGYPRYDEVPVEDGGLYSTASPTRYANNAQSRPAKTDNLSSPSRSGSYSTAPTDHYAFSSAFSDATWGDEFDDYDEDFDETCVKNVNICTDLESPAGEPPPLPPRTYMMSCGGSQRDKTSPEKPYILPLKQDGQQLSHTHYFLIPPLNKQDSQPSSSSSFSSSSASSSLAQKRDHASSPSHSNKSTATVRPFVVNAGYDATDDRAEQHLDYENLSGLIPRDVVHRSLSNMSSASSRSSGGGSGGSDCSSPRHHHHHQHHPAPSVHHSHPHHHQQQQQYQQQHSAGSSSPRSRSSSSSVSSRPRPIQPSSDRSKQRHPTTSSSSFTSSSFSSSSAHYATRNNDDPGMFLSSSPHDRIAAIQSRVIGVTDEECHAALCTFHWDVDRAVNYLKVEQLFRLGVASRPSCQRLLETLDWNLELASSVIFDEVQSKKKPCESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ47</accession>
    <name>A0ABM0ZZ47_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein sidekick-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937506.1">
        <property type="nucleotide sequence ID" value="XM_013082052.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856889"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="14"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="262"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="363"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
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            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012937506.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="56989" checksum="92ACAC3D1F797019" modified="2025-10-08" version="1">MSSAHLQIKSAPDPPINVKVMSCHGNSANIVWEEGNNNGAEIVGYTLQFNTSDYPDMWYDYDEQFDRNARAATLQLYPWGSYSFRVKSRNSLGSSKPSPATSRTCTTPPDRPDRNPSNVRTRTDKKKTLIIEWTPMSRLYFHGPNFRYQVKWRSKGTFIWGSILVTDPNQGHTEVETNDVYTVYELQLRYWKASEEWKNKKKEVEIILGEDLQSHGPQIKVALSDLPAYTTLRAQVAVMNSHYTGPFSDELDFFTQEGVPSSVRDLRLQARGVAYVLLKWKPPQQPNGLITGYDIAYQPVSGVQLGQARPLLPHINDPSVLGARITGLRPGHRYRFIVWARTKKGRGEFAFIDVMTAKGQPPHPPRVQVSELRNSSVNITWMSDQATRDMKYQVEYRQPGRADWHNTEYVYDKSWLMLDRADVPVSDLEIRLVASNRLGDTATSRTIAVAKIVQQESSHKQKRTPNTNKGSSATSWHWSTSLISPGLGVATSLLLTNLVFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ49</accession>
    <name>A0ABM0ZZ49_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011655</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937508.1">
        <property type="nucleotide sequence ID" value="XM_013082054.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011655"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937508.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14585" checksum="2249D751935D6B04" modified="2025-10-08" version="1">MYWPGREGTGFWVECRSERTVMQGQCGRADDGSYKIFSAQYSRCAAYSEIVSEICQWTGGLIPHEKDCHRYYDCSFHDPAMPQGSPLAYLVTCPYPQLFSVHSRKCEDYKLVSCGPRTEVKTPCEWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ81</accession>
    <name>A0ABM0ZZ81_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transient receptor potential cation channel subfamily A member 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101849923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012937564.1">
        <property type="nucleotide sequence ID" value="XM_013082110.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849923"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="775"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="889"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="913"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="953"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1025"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="544"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
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        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="856"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012937564.1"/>
        </source>
    </evidence>
    <sequence length="1190" mass="134579" checksum="35ABCCC074121146" modified="2025-10-08" version="1">MLFLTNSIKTVPDTLNMWKYRKHSDLFSRIGLFGSKRKYETETVFSSVNPRDASSIFGESYTGDREIGLDLDLDLDLVNVEILSTSSYEENPISFLELFQATADGDTEKIGQLLLAFPTRINIPNSQGNYLIHIAIDSNRPDVLSFLLSKGADVNVTDQDGKTALHHAVVEQSPEMVGILVLRNARTDIKDIHNRMPLHTAAEVGNVTILERLLPHYVNPNMEGDGGYTALHYAASRDCADAVRFLIKKQCLLSVFSECRDFPIHVAGKTGSANAVRTILEECQCQGFTKEGILRLRDRERNMPIHSAVNGGSIEAVKCCLQMGSSLICKQEDGWTPLHFAAMQGNLDMVVAMYNGQTEEFRSAVCIVDGLRRTPLHCATLFNHTAVMKFLLDKGANINAVDDNQFTPLLLAASKGKLEATKMLINYGADTTFRDRWNRNLFHLLILSNKVIEDLSGCVKGVKKLYLWLGEKDRNGCTALHYAARYGNLSAVSALLSMGASLFSKNFQKQSPFHVAAMYGRRGICKLMLDTAFAVSLKNEPDGKGLTPLHLAAQNGYTKIVSMLMERGAVVGRDHKDNTPLHLAALNGRVDCVNILLNLQINLIDSGNNSGNTALHFAASNGHTESVCILLSHDAKITRNDDHRCFYDDIITHQHAETAAAIVAHERWREILSYKSAVYGSFLIGLIQKLPSVCQIVLDRCVEVVEVRKGDTEDHAIRYNFDYLNMQNGFKTFAKLNKLSYKAMYPLQEMVTFNRVECLSHPLCVRFLRMKWRKYGLFIHFFDMTFYLLFLACLTCFVVTVDSRFHTDQLYPFENFNTFMTATYANNRTDGIAGTEHFLHYGEIYYHIFPESIRIMHIYIMTYCCVCMFKEMFQIFAMHHHYFTQPINLVEWVVYLSSVLFILPFLFGYSTHLQWAAGAVAIFFAWFNCLVSLQRFDLFGIYVVMFLEIMKTLVHVVFVFSFLNIAFGLAFYVLLSGEKNEAHSSPSMSVYRTLILLLEIDFINTFNRQYHDTSSHSLHFDRLTYFFLAVFIFLMPILLINLLIGLAVGDIESVQRGARLKRLATQVKFHAEIEDRFGFLEKFSDAVVEVRRDKTDSVFNEFYSKTNPTKLDGKEPVTDETSSLGQELKIQKAMLKQIQTSLDSNQRLMSTMLDRLDGNGNTKAWDEGADHSVSAMSVGDSSLSEEIRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0C7</accession>
    <name>A0ABM1A0C7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized histidine-rich protein DDB_G0274557</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938242.1">
        <property type="nucleotide sequence ID" value="XM_013082788.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011815"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938242.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20732" checksum="89922F99FE7BEE8E" modified="2025-10-08" version="1">MSSRQPPHSRHVSQQHQQNTAHPAHPDHRAHTPNTHQSAVTHSAHDPHHQRQLLTLQEEEQQPQQHHQHHFPYPQKQQQQQPSQQHPHHHPHPRPSQSCAHPPPPVWRHGVSDSGLHPTSRRAYPYPGTRFRRSSRSRVRTLSTPLSCAAAPEIKYNLTPNRPRIRSRSVSQSSTDSYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0X5</accession>
    <name>A0ABM1A0X5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101853792</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938583.2">
        <property type="nucleotide sequence ID" value="XM_013083129.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853792"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1490"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1570"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1D8</accession>
    <name>A0ABM1A1D8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 49 member A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012938860.1">
        <property type="nucleotide sequence ID" value="XM_013083406.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854091"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17399">
        <property type="entry name" value="MFS_MFSD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="117"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="147"/>
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    </feature>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="468"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="52"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
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            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012938860.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="53991" checksum="4F199611F2EAD1FE" modified="2025-10-08" version="1">MENQEISDKMGQGRERPEDNEPIIVTENVLDQHYEYLRDPSGYTVYTRRWFLLFVIAVINFTNAMIWIMFSPVTDKTSQYYGVDPTGVNWLSLVFLVASIPCGFMASWLLDTLGLRASIICAAWLNFLGSVIRNLTAYSFMPHSAQFPVLIFGQVVAACGQTFVMFTPAKTAALWFPDSQRTIANTLASMSNPLGILAANVLSPALIKKSDDLPVMLYICTGASLFGVLLSTFGVCSSVPPSPPSPSAAAQSEPFFLGIKKLRKNFAFWMLAFSMGGGLALFSAYTTFLEQILCPQNYDNSFAGLCGALMIAAGAVGAVIAGVIADKTRKFSEVTKLGFVFSNLAGIAFVQLARYRDLEYPVAICITLFGAFGFAVYPTALELAVEVTYPVAEATSTGIIFISGQVQGIVLMIISQYIAQPLSPHAASLPQACPSDGEFDPQDWTIPNLLGNGMGVLYTVAIVLLFRAEYKRMKVEDRHKIEQTLQGEIDSPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1R1</accession>
    <name>A0ABM1A1R1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protocadherin Fat 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101846289</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012939056.2">
        <property type="nucleotide sequence ID" value="XM_013083602.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846289"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046019658" evidence="9">
        <location>
            <begin position="35"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="42"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="153"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="261"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012939056.2"/>
        </source>
    </evidence>
    <sequence length="436" mass="47382" checksum="480339FB9C5FB412" modified="2025-10-08" version="1">MPDHTRRKKHRARSGLMYWWTSMIIFCMLQRADAGNSPPICNQELYVFNIPENEAAGTLVVDLGAECRDPLDGDVLTFSIQTANIGNQFTIGTNTGRITTSFSPNAEALLGNGLNYISPYPMNIFVQDTDDETFVVSVVVHITSVNDETPVISGLPSSLTVAEDTPVGTVLDTCTLSDADYPGFDHSQTEVEISSGNEDGKFVVDYRTCDLVLVSPLDYENTQQYTLTLRVYDLDPINPLSSTFDLTIDVTDVNDNDPTCSSYNHREALIEDSLAGEVVHTVTCNDLDTGLGGTLTYTITAGDSDRLEIKDNTVGDISLVTSLDYEAGDRFLEVEVTVSDSTAPTFSTTVTLAFVVKDADDNPPQFSAATYTNNVLEHAAIGLVVVNLVTSDLDEAGTDLATPTYGFEGACNPNDDWFRVDAHTGNDIYLFLSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A233</accession>
    <name>A0ABM1A233_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arylsulfatase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101859713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939262.1">
        <property type="nucleotide sequence ID" value="XM_013083808.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859713"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047354334" evidence="7">
        <location>
            <begin position="20"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012939262.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="56903" checksum="E4CB6A896726CE35" modified="2025-10-08" version="1">MMTLFLRLLFAVWLAAVSGSNNNNNNNNKRPNIVFVLADDYGFNDIGYHSPDISTPVLDQLATEGVRLENYYVQPICSPTRSQFMSGRYQIRMGLQHGLINSGQASALPRDSPTLADKMREAGYATHLVGKWHLGYYKQEFLPFNRGFDTFYGYLTACENYTSHKRVYPQDGVAYLDLRDNNGPIHNENGHYSTHLFTEKAINVVQAHDTSKPLFMYLAYQSVHDPLMVPEEYEKKYSHIKDEKRRIYAGMVAAMDEGVGNVTKALKDKGIWDNTILVFSTDNGGQVYGGGNNFPLRGHKHTLWDGGMHGVGFVTGGKMPVKGLVNNELIHVTDWYPTLVNLAKGSLNGTKPLDGIDQWDTITAGKPSRRTVLLHNIDQLFPKRGVPLYNDTFDTSVRAAVRVGDMKLITGDPGDAKWWPLPGQKVDFDISDERHKHPNKNVWLFNITADPNERHDLSHQMPGTVRSLLRYLVKFNAESVPPVWPTHDWRSNPSRHGGVYGPWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4A3</accession>
    <name>A0ABM1A4A3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106012355</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106012355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940554.2">
        <property type="nucleotide sequence ID" value="XM_013085100.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012355"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF43">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047239623" evidence="2">
        <location>
            <begin position="26"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Glycolipid transfer protein" evidence="3">
        <location>
            <begin position="671"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940554.2"/>
        </source>
    </evidence>
    <sequence length="848" mass="94701" checksum="513918FD7411C8C3" modified="2025-10-08" version="1">MKAVKVLCVVVTIFTVGGYVQVTECSSKTDVSSRTLSGRQDSERRHVLQEAGSSHRKHRGRKYRSRKKTIRYRVTVELPDKTFEDPLGDRSSNRFQSLRKKLTADIDRLLTKMVGKHRLYNMRFSKIYRQRKKRKNISATIRKITTITPWKWRKTSRRRGDVTTPMTPTTSEEHDGKTSPTSKIPTKKKRPHKNRRRWRKLQRLHRRRGGKKQRRKHWKRRKTKSSSSVKSNTKSKKNRNNFEVVVTRTSEQGNSNNVTNSSSEETIFISPLEETRTAAKNLSTPLPASVVSVTPPTDPTIKTRIEHTSDFDSVRKQENALASPKNVNRPRSTTETTTSTPTPTSTPGVTGPSGFLWRSGFNNRAPRKYSRRHRQHTPGSLHAPLINISTIAATISPPPPIPPIAVTETSSTFKVSSSTVLKDLKERAEKFNSTSDETGLRASSRRGTLQSHSVTSPKPRLPPPSGGLLATTTAPQPASAETATIATSAGAVGHINTPVLPHSTATSNDFDLRNRASQNRMFPVTSDVSPPHTTPSITSPAPVEAVLGKKKPIVTTTNQAMYVESSTQSSLDLKSSPITHTKFVRGQGPYGGAADQTSSIPEATQKTPTTPTAEVGENSSTSSKLDNVTAGLLTTREMATSGVPFYDIRTTSKLFKQCVIYSPLTKDYAISFDLYIRAYLDLVRIFGFFGPVFSFAADDINDKLMILSDLKEADSRRGYSHYETIESMFEFEYSEGQDTSGVDANRWIHRALKFISALILELRNSDSKEHMSARATALYSELLGPYHEWYIRMGVYVAMLSFPSRDLLLKQINVADNPAGMQLLEDASSVIDAVYEEIEMLYEEYTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4C3</accession>
    <name>A0ABM1A4C3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Midnolin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940591.1">
        <property type="nucleotide sequence ID" value="XM_013085137.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846664"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039336">
        <property type="entry name" value="Midnolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23010">
        <property type="entry name" value="MIDNOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23010:SF1">
        <property type="entry name" value="MIDNOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="153"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940591.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="51820" checksum="A3F78F25F40B9A3E" modified="2025-10-08" version="1">MLAIRMGEHMVFVQLQLSTLQHQQQQQQQQSQAGGGGGGGGGRQPQGEGQGGGSSHQAPRAGVTGVTGVAPTAATVLSQTGLSASAIAEATRCLSQRMQLHRLQGINRSSNSSSSRSSNSSSRSIGARTSSSMAGPAQQTRSAVASHPPPRMSTQRSAHSSSRRSLLSTPLSPSSSAHRRSTAPYPSAAPPRSSSSSSSSSSSSSSSSSHPIPPSTTLTSTPAASGVGPAQTLLQLPTRSNLPAVADNAMPSPPPSPGAVIDSMKHVGRGVYTGTFSGTLDPSLQDGNGQPRRSVNTILHILNDLLVAAPHSPPATPVRAQGSSPAPQAFPFNPPTTTSPANLPPTTTSPAYLPPTTSPNLPLTPPVSPKSKTGPGAVFAPREDTDNDKLRRKMQHIQTMLAQRKEQRRQRREMNAPYTTSKSAAVQGLADVSRSLPASSSAPSTVTVAATDLVSPSICRTSSSVTSSSSTATTSSTVSGHGEGNANGGGDSSTYCKTSIEQDSLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4F5</accession>
    <name>A0ABM1A4F5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable deoxyhypusine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940644.1">
        <property type="nucleotide sequence ID" value="XM_013085190.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851133"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940644.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44608" checksum="7D95BA85226A595A" modified="2025-10-08" version="1">MDKYGDRTRDEHEVEEFIRGNLDRMTLNARKFTLAESESDPMPANSREVKGYDFNNGVNYSKLIQSYAGVGFQASHLGRAINVVNKMIDTRFQPIPAGVRTEGHKEHIFANRRVTNCTIFLGYTSDMVSAGTRELIRYLVEHNMVDCIVTTAGGIEDDFMKCRTPFYHRNFRMNGADLHKRAHNRTGNLIVPNNCYREFHKFLNPILEDMREDQMLRTEWTPQKLIWHLGKEINDPASIYYWAYRKRIPVFCPAIRDGAVGDVLYFHRHVRGRTAVKLDIVEDIQALNDMAVQSVNTALITVGGGVIKHHILNANTFRDGADFSLFINTAAEFDGSDAGASPDEAKSWGKISPQRTPVKVFADATLVLPLLVAETFAKREDEFKVFNRTNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4N3</accession>
    <name>A0ABM1A4N3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold-shock protein CS120-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940771.1">
        <property type="nucleotide sequence ID" value="XM_013085317.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012406"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34147:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 WD40 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34147">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012940771.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31091" checksum="58A452EDE26C14A1" modified="2025-10-08" version="1">MRQHWTIWDTLGQYGTLLDNMGHSGTTRDTLGQHGTTWDTLGHSGTTWGNMGQHGTIWDTLGRYGTLWDNMGHSGTTWDNMGHSGTLCDNIGQHGTTWDNMGHSGATWDNMGQHGTTWDNMGHSGTLWDNMGQHGTTWDTLGQYRTLWDNMGHSGTTWDNMGHSGTTWNNMGHSGTLWDTLGQHGTTRDTLEQHGTLWNNMGHSGTTWDNMGHSGTTWNNMGHSGTLWDTLGQHGTTRDTLEQHGTLWNNMGHSGTTWDNMGHSDYLYLNFWNKRAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4P4</accession>
    <name>A0ABM1A4P4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructokinase</fullName>
            <ecNumber evidence="4">2.7.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101850972</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012940783.2">
        <property type="nucleotide sequence ID" value="XM_013085329.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850972"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="54"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012940783.2"/>
        </source>
    </evidence>
    <sequence length="470" mass="50878" checksum="6657048C1323B607" modified="2025-10-08" version="1">MESNTYVPAYYARRQTLMRKSMAAISASRFDQSTARLLSSVENRSHNSWLGATVGVVTAGDDSQGMNACIRAVVRLAMYLGCDVYYIKQGFKGMVDGGENIVEATWISTSDVIGHGGTILKSYKCPSFTERESRLKAVHNLLKAGISNIIAIGGDGTLRALNVLHEEWPLLLRELHDRNQITRELAAKHKTLRAVGIISSIVHDVCGSDVAIGVDSALHRIIEATDAIATTSSSSQQVFVVEVMGKKSGYLALTAGLACDASMIFIPEWPPEGDWTEELVNKIKEDVAVGKEGILVVVSEGATDRQGKPIKAEEIRAVLARKLNLDTRVTVLGHVQRGGIPSASDRYLASRMGAESVLALRDLPEDMSACAIGMVGNNVSCLDIGYCLENTEKVWQCMLDKNYTEAVRLRGRLFQSFLSSYAILHSLRPAAVLSIPGMSGVRKIGVVKIGKTTLGHCCVTKSVVGYCLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A558</accession>
    <name>A0ABM1A558_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101845345</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941027.1">
        <property type="nucleotide sequence ID" value="XM_013085573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845345"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941027.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59649" checksum="440ED9A19E9E8953" modified="2025-10-08" version="1">MEEVEETLELHQLDSLDCPFHQHLLRALGHLCEDLQELVQQAEGRGQEGEELELLKGGVWEVIDSYHLSMSGLHTFLAGLERQTHTLDQHLALLDRKRLELLEERDELIERGHELNCRIGYNALERKLEETFTSTEKYTTMESARCFKDEAEEDLRRCNDVIRTGCMRACQIDRDLFDEMEKITDLFENYERDREHYVKELDLFADVRRIRISSWLAEGREEGDRERGENVLDYLNLTEKQRHMEPQVIKNALRMYSFNASMTFDREDNQKHLEELTSVQSQVNSVSGLSLVVPRWAVGRTNLTEDVEWGRASEEGAESDDVTADHGTAGRGLHKCPRSLHLATEPVTESETVGRLDVALRWAEPDVGSPAHQEADSSLSDVPDPALAFSSSSSSQDEVKVMTSTCGDVPSVMALETGADVRGVVKDPETAHPERTSGSSTQNLLQHMESCTLIPAGAGKHMAGLVRRKKPSGRPVGSLTSVVDTDTQGSGHKLAAGESQERVTRSQGSEPSTRATTSGNKSREHVMSWDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6Q4</accession>
    <name>A0ABM1A6Q4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12" type="primary">LOC101861528</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="RefSeq" id="XP_005105434.1">
        <property type="nucleotide sequence ID" value="XM_005105377.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105436.1">
        <property type="nucleotide sequence ID" value="XM_005105379.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941897.1">
        <property type="nucleotide sequence ID" value="XM_013086443.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827488.1">
        <property type="nucleotide sequence ID" value="XM_035971595.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861528"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005105434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005105436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012941897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035827488.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="50469" checksum="80A21EC85FA9ED48" modified="2025-10-08" version="1">MGKHLITWSVSQRICKAASWMSPRLASRHTSEACYNQSLPGMLESTKRCRYYTTQAQPENLLLKHLKARIKSNGPMPVADYMKEVLTNAYSGYYMHKDVFGKDGDFITSPEVSQMFGEMLGVWVVNEWMNNYNGQTLQLVELGPGRGTLADDMLRVFCQFPSIKDKISLHLVEVSPALGQMQASKLTGKDTSEVEEGDSDCVGAYRNATSKYGIDVSWYRSLADVPQGLSCFIAHEFLDALPIHKFQKTEAGWREVLVDEDPGNPDALRFVLAHGKTPASVALLQVESEEQRNHIEVCPSAGLTVQEICQRIQSDGGMALLADYGHSGEKGDTFRAFKRHKLHEDPLSEPGSADLTADVDFSYLKSFTNADVDVFGPVTQEKYLINMGIGVRLQALLQKSSQEHWPSLISGFKMLTSPDQMGERFKFMSILGKTGSSYKPAGFVELNYGDGQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A707</accession>
    <name>A0ABM1A707_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101858660</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942085.1">
        <property type="nucleotide sequence ID" value="XM_013086631.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858660"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046528854" evidence="3">
        <location>
            <begin position="35"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942085.1"/>
        </source>
    </evidence>
    <sequence length="705" mass="76214" checksum="E65CAC8B3F09FEB7" modified="2025-10-08" version="1">MAKLLNDGAVSLLSKVNGLFFLLSLGVFIPGAAAEKGLHAAQTVDVCQDVHQFRCEDGQSIAISDVTCGSGRYACEPDANRTLFDLCQGQQACTSLGLDAMLGRYCHSGIRARASIRVQFQCLSGPPPTSCRSNVCEENSLGLRCPKDHVLHIQKMACAAGRASCSQSSRVTLYTLCEGSQHCDASGLRSLLAEHCMAADKSSRSVLVHYVCLPAQRAESVCSTSRYRKLSQDFGLIKTPDNDNGGGGGSRGRGRTSAAAMCRWILDPGDREQIKVTIHLVLPKVTGAPCRSSVLDFQYFECGSKLTARQSFCEVMDAPEGLASCGPVRIMSHVPVGGATPDDFVLSYQRLKSAQSPQSPPPAGLPSCPVPAAKNTSTSSSVYSGRTAGQSPTTDESSGGMSRELKLMILYICFGIVILGLLIALIVVIISYRRISRRKSVSDSSEKAALWRRDDTPLDTFPNNSLAEGSGSHTSETTYAFKSPQDTNQVVATIHNDAIFDSEDLDHRTSTGSGISTFLSNKRDSDFRDLIHTFQTGTFDMSSSVEDTNGHYPDHMTGSSHYEGTGSELGDIYEVIDRVPPAHTTTGRALENGYSNGYDNGYDNGYHNHPGDSQDMRPLVNQRGSPCDDLHYCINNDEYAIVQKNRKTPRPVSNAHVNNGSVVEPAVPESDGVVDFRPTSGPYDKKRMSSASHRSSRGDRWRDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9G7</accession>
    <name>A0ABM1A9G7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline-rich proteoglycan 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943378.1">
        <property type="nucleotide sequence ID" value="XM_013087924.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855823"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943378.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45062" checksum="D6A7C36460D19C41" modified="2025-10-08" version="1">MLKERDLDKATIDAYHYYVQRGIRNDLNSVWLGPGKLPFRAAIALIVFALCCLLVGVLLVALRMRHVYLWDWDSQFLGPFFIILFLLCMAGASYLFIIAKRRSNKYRAELYFKPVGDWGINCVHKSELAREEELKHELKSGTTPHKTVKPRSEAYSQSSRDHRRGHRNGKDNQGYDKSPLDANRQFRPDEQRRRGPPPPDGRRGPPPEGYRGPPPPDGARRGPPPDGRRGPPPDGYRGPPPDGRRGPPPDGYRGPPPPQGQRGPPPDGYRGPPHPQGQRGPPPDGYRGPPPGGDRPRGPPPAYREERGSPPSRRSPPPGRRSPPPGRRSPPPGRRSPPPNGQRGPDDRRPPPPQGGGARIPLDEEQGRRPRGVPRFGGVERIPDEDRRDFKLILNKSRDESDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9Y3</accession>
    <name>A0ABM1A9Y3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutelin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943657.1">
        <property type="nucleotide sequence ID" value="XM_013088203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013178"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943657.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12177" checksum="CEAC0D68ACF1E3A5" modified="2025-10-08" version="1">MTEPALPLKVLPGKDVPEPALPPPVGAPPPFAPPVSAPPPYAPPAPGCGYGTNFSTDYGLNLHQPSVAQPYNYNYNVQQPQLYNVQQPYNYNIQQPLTNNVQQLQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA44</accession>
    <name>A0ABM1AA44_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein heavy chain 10, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943741.1">
        <property type="nucleotide sequence ID" value="XM_013088287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013204"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943741.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15244" checksum="1D702C12A04C0A85" modified="2025-10-08" version="1">MSPVGDTLRTRCRNFPGIVNNASIDWFFPWPDQALYAVASVMISPENKLIPGEHREHLVSHCVKVHQSVNDYSQRFLQRLRRYNYVTPKNYLDFISCYLRILDEQDQNIQAQCERLQGGLMKIAEASKMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABZ7</accession>
    <name>A0ABM1ABZ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">17-beta-hydroxysteroid dehydrogenase type 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944806.1">
        <property type="nucleotide sequence ID" value="XM_013089352.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859280"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF50">
        <property type="entry name" value="GH26015P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944806.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34814" checksum="1D297F0BE1A02BE7" modified="2025-10-08" version="1">MLILFVMLFAFLGWLVHWFLRSLVVGDFDDKYIFVSGCDSGFGKHFAMRIDGKGFRVFAACYTLKGAQDLAAQCSDRLTTVQVDISCTESVREAAEIVKSKLPPGKGLWAVVNNAGYTGNLARSEMLSREDVLATLNVNLLGHMDVLKRFLPLLRRERGRVVNVCSVVGRVAAVHAAYCVSKYALEAYSDILRREMVRFGIRVIVIEPGYFKTPIVNAESAMERLTNSYNSLDEEVKKAYGVDYLASVKAKLRNGDNPDAYKQVVDAYVEAVTCRFPRSRYMVGRDAVWYFRPLSFSPDWLQDLVITPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE79</accession>
    <name>A0ABM1AE79_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 3A16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101852816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945993.1">
        <property type="nucleotide sequence ID" value="XM_013090539.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852816"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012945993.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58854" checksum="C7B0A5BF3ED78C97" modified="2025-10-08" version="1">MMELSVLSWALLSLVLLLVVYVFYMSSSLRLFRKLGVPGPAPWPIIGNFHLELKHGISNYHRQAYQKYKSERVYGLYRGKQPFMVICDLDVIRDICVKNFDHFVNRTTYETEEPFSHALTQVKDEHWKNIRTVVSPTFNTVRLKRMFAHIKTNGQLLVKYLENRQERNEPVELKEVLSRYTMDVIASTGFGVQSNSLEDDGSPFMTEAKRLMSGPGFLIILAFFLSFLKPILRLLNISKLPRQSLQFFRRFVDAAVESRKGEAGTVQSRNDFLQLLMEAMHDKDGEDDNMTPEELAALNSSGVKRKLNYVEVQAQALLFLLAGYETVSASLSFTLFLLALNPECLQKAQEEVDEVLQGKFPDYESTQSLHYLDMCLNEGMRLYPPTPLLDRVCSDDIEIRGIRIPKGVNATFPVCAIHRDPDLWPEPDKFIPERFTAENKANRHPYAHMPFGQGPRNCVGMRLALLEMKVALAAILQKLTPVRCEKTVYPMNFVRFRMLAKDGLWVRLEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEB4</accession>
    <name>A0ABM1AEB4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">LIM/homeobox protein Lhx5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101851555</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946044.1">
        <property type="nucleotide sequence ID" value="XM_013090590.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851555"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09367">
        <property type="entry name" value="LIM1_Lhx1_Lhx5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09375">
        <property type="entry name" value="LIM2_Lhx1_Lhx5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049618">
        <property type="entry name" value="Lhx1/5_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049619">
        <property type="entry name" value="Lhx1/5_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF105">
        <property type="entry name" value="DLIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="250"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="252"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012946044.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="39527" checksum="CD1F6364834E2E8E" modified="2025-10-08" version="1">MMVQCAGCDRPILDRFLLNVLDRAWHASCVKCSDCKTNLTEKCFFREGKLYCRTDFFRRYGTKCAGCAQGISPSDLVRRARSKVFHLKCFTCVVCRKQLSTGEELYVLEENKFICKEDYINSKYAGSDVEDDGDMDSGIDTQCNISDKDFPLDGESSPHDSKESILGSIPHALSAGGNNNNNNNNNANNNNNNNNNNSFLNVNGNANSNNSLSNNSLSNHLGASLGGAPLGCAGLTSHGAGNGPGALVGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQRSCFDDRPLTPVIAVLQRPPYRTWRWDYTGRPTVSGLPGRTLSPKVKVAVAHSGVINAFSRHLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEJ7</accession>
    <name>A0ABM1AEJ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase AMFR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC106013891</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946175.1">
        <property type="nucleotide sequence ID" value="XM_013090721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013891"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14421">
        <property type="entry name" value="CUE_AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16455">
        <property type="entry name" value="RING-H2_AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="11">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="309"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012946175.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="41859" checksum="7D22FC0CD9A1A2E8" modified="2025-10-08" version="1">MEAKFPMATQEDLEHNADDCAICWEKMESARKLPCGHLFHNSCLRSWLEQDTSCPTCRTALSETPQGERNPMGPPGAPNVADGIVPPAPQGTTNHFFHFDGSRYVSWLPSFSVEVTHTNLLPGQQAHATQTSQLDNMAREVQVVFPSIPQQVIMEDLRVTRSVDQTIDNILEGRLIVPQVASISSTGHSRTESPGSPGESSSVTELTQVTQSMPPQPIMSADITETTTADSETTAAKTTAAREPTTADSDLLELSPQTGDTTGASAGHEEGQKFASNVSAGGRFSKSASERMSMLGQRKQAMIEQARRRYQAKLEKASNEKTSNDWTRSTAPKSSTAGGTAGIVEPSTHRATSLEQESAAEEQWRRRAVVLEATQRRLDRTSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFH7</accession>
    <name>A0ABM1AFH7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransferase 6B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106014131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946645.1">
        <property type="nucleotide sequence ID" value="XM_013091191.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014131"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012946645.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33961" checksum="0A091A01ED698C29" modified="2025-10-08" version="1">MPLENVADEDGYTLKFYRKSDGRLSGNLTNVDTIENLPSLPLRDDDILFCSYPKSGCHWVWENVRILQTGEIKLDALPKERFFFEQNERDYFNNLPSPRFLNTHEHFDRLPRDLLKGKMKLVLLYRNPKDIAVSFYHHHTRLPYYRYEGPFSSYIKRFAAGQLNASCVFDYWREFEEGLKQNPQIPHIILSFEDLKKNPLSERHRLAKFLGRSYDDEFIEQVAEATSIDNMRREKEGPKDEKGSIYYRKGEIGDWKNTFTVAQSERLDSIIESKLKGCQMFRFVYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPF9</accession>
    <name>A0ABM1VPF9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 26A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101856325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824301.1">
        <property type="nucleotide sequence ID" value="XM_035968408.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856325"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF384">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824301.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="60137" checksum="646E941D6E0CC9DC" modified="2025-10-08" version="1">MCLREYVCIITHPSVNQAVIVVYLFTSLIYNPGWLLLQTLVPVVLFLLSVIMWSVYHTHTADPTVDLPLPPGSMGLPIVGETLSFAFGIKDFFGSRRKQYGDVFKTHILGIPVIRVVGAPHVRKVLMNEHSLVSAYWPRSVQILLGSHSVATAAGEVHRSRRRGLQRAFSGEALEGYVAMIQRIHVFPLSQTVRERIKTWCSKDSVMGYLESKRMTFALSCETLLGISLPTEDHNALVELFTVFTENIFSLPYNFPGSGLAKGVAARDAIYATIEENLIQKQRVLRERQARNDGEDQFPRETMDAMSRLLLASGENEALTVEELKEIGLELLFAGHSTTGSALTSLILQLGNNSNVVSKIREELEAHGLSRPEQGDLNLYVLSKLEYVSAVTKEILRMTPPVGGGFRTVLKTFTINGYQIPAGWTVNYGIRETHECTDVFADGEKFDPSRWLTHREQEYKFHYLPFSAGPRTCVGKEFAKILLKIFVLELVRSCSWELVGDSVKMKHMPVPYPADGLPVRFTEFNSRSDRINSDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ06</accession>
    <name>A0ABM1VQ06_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MutS protein homolog 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824498.1">
        <property type="nucleotide sequence ID" value="XM_035968605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861565"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035824498.1"/>
        </source>
    </evidence>
    <sequence length="904" mass="100751" checksum="94110BD160826BE7" modified="2025-10-08" version="1">MSSVIRHPKYAFGLLQTPSDSENGKSGKVHGASSSASVYPSFSSSSADRTEQQSNLCTPKLQNRTSSKISSSSLLESCSSSIRTPRGRKKTSTPRTASSSVSNDVNSTTLVAVVEGRGVARGEIGMTSLDLSQPVLNLSQFSDSQTYSMTLAKLQNIHPVEILLPNTICDAGDKNKLLNLITCQFPNVTISSVQRRYFSETKGLQYVKQLCATEYKNIELQISTKYYCLATTGALLKYMEFIQNVMFAPNSLKAVFKGCENSTMIDSATVKNLELLQNLRDPISQHSLFGILNYTKTAGGGRLLRSNILQPPSDEETIVLRHGAIAELTEKEDIFFGLQSVLSKFVDIGHIISVCVQIPKQETLRSAESKLNCVIALKHVLQLVEPLKEHLSYCENKMLKMYYKALDDVRFKTILEKIGEVINDATHLEKGALQQHYQRCAAIKTKINGLLDVARRTYTELVDDLESLVQQCAENYQLPLRTAYSSLRGFYIQMSIETRGKRGGGGGAAAVSQDNLPSVFIKVNKFKNTLSFTTMELLQLNERIKSALDQIYMMGNFVTTDLLTSLQGQVSCLYELADIVAMVDMLLSLAHAATLSSYIRPEFTDTLAIKQGYHPILQKVSCDIVVPNDTYAADHSNFIVLTGPNMGGKSTYLRQVALLQIMAQIGSFVPAQFASFRIADQIFSRIGSDDDMESNSSTFTLEMKETNYILQNVTDNSLVIIDELGRGTSAEEGVGICWAISECLLKKKAFTFFVTHFRQLTDLNRNYPNVSEYYFEVQRVFNAEARCEKISYTHVLSRGVTPETHYGLQLASMSTIPTSVIEDARKIADNIEQRREKTRRRDIVVLRQHADFSLAMKLIQVAKNSRMDEDALRMYLKSLRKTYLAELEKLTTTANAQMSTSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ19</accession>
    <name>A0ABM1VQ19_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protocadherin gamma-A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824511.1">
        <property type="nucleotide sequence ID" value="XM_035968618.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846634"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="15"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824511.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13128" checksum="4674334F3ECD199A" modified="2025-10-08" version="1">MLFVSDINDNAPVFVGLPYRTTVRENAPVGSSVYTVSATDPDTGLGSRPVFSIKANIPANQADYEATFTMNATFGYITLRKKLDYETRSFYHFRVSVKSLYIRSVSEDAPVVRFTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRK2</accession>
    <name>A0ABM1VRK2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Apoptosis-inducing factor 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101849043</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825044.1">
        <property type="nucleotide sequence ID" value="XM_035969151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849043"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="11">
        <location>
            <begin position="101"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035825044.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="67120" checksum="A6C66909DEB38804" modified="2025-10-08" version="1">MARRVLFSLGHKWLQSTSLVRLSTTHVLPAYSYSLLIRPSSHSLIGNAGVKVVTVRKFEGSDDSKNKNPAEANRPVSTSATATQASSGGGETTPTASMIESVVGKVGDFNDGEMKEVEIGDKKALLVKESGQFYAVSNKCTHYGAPLTKGAYCKGVVRCPWHGACFNVKTGDIEDFPGLDSLQKFEVEVRGEDVVVRADPASLENNKRVKAMVRKAADNKKTVVLVGGGPSTLVCAETLRQEGFTGRVVLVSQENCLPYDRIKLSKAMSIKPEEIALRKADFYENNGIELMLGQQVESVSTSDKKLNLGSGESLGYDTLVLGTGGQPRRLPIPGIELGNVYMLRTPADANAIAENAVGKNVVIVGSSFIGLEVATFMVNKAASVNVIGRSSEPCGHVFGPQIGQWFRKLHESKGVKFHFETSVKEFRGEDGKVTEAVLANGETLPADVCVMGVGVVPATQFLQDSGVDLTSRGFVTVNKKMQTNVSDVYAAGDIVEFPLFTAGDQQANVQHWQMAHMHGRIAGLNIAGKPTDVHSVPYFWTVQYGKSIRYTGYGPGYDDVVLHGDVDEGKFLAYYTKADQVVAVASLGWDPVVSQAAQLLNQGGSISKAEITSEPSSWVSRLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRZ5</accession>
    <name>A0ABM1VRZ5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Basal body-orientation factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coiled-coil domain-containing protein 176</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101848105</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BBOF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825187.1">
        <property type="nucleotide sequence ID" value="XM_035969294.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848105"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032777">
        <property type="entry name" value="DUF4515"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF5">
        <property type="entry name" value="BASAL BODY-ORIENTATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14988">
        <property type="entry name" value="DUF4515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4515" evidence="12">
        <location>
            <begin position="82"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="244"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035825187.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="61690" checksum="CD6A5C594870FC74" modified="2025-10-08" version="1">MPKKGKKGKGKKGKKGKKGGKKGGKKESVVALATANAKVWEAKLDIAEKSKQDFRENAKKLMLENDALQTQMFQTERDTIDVITFLKKQDQDKDSQIERQQQQMRDLKKDHRKEKDGIVEDFSKQINDLEEKLGEKMREVDLMHSELKLVKEFRRKRGQMQKELEDIKEAMHTANRDHKSTLGRMEQKFFEEKMRLQQEANQKIAELAEKAHTEAISNLDETTKSVYKENVRLTEALNYHMKEGDLLKKERDRLQEENDNLKQEKEVTDMMVQDKVVQVKQQKETIKELSDKIKTLEKSLSHVVREFETEQKSIVQRSETENQAGKVELVKLQRVIELKTREMNKVKRLAKNILDERTELERFFLMSLEQVKAEVAANQAQYRKDAHAAYRQKMLEAHTGKGDFPKIRTFNQMEHSTNSVFRDVEAAEMLKKLMAKYDVSGKVDISDLTWEQKERVLRYLFAKMNGNKTSQRYAPLPGIGQGEAPLSITQGEQSGAEEGRNSTFLTQAHMDMVNQFQKHGLLPPEPPAQAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSY0</accession>
    <name>A0ABM1VSY0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Calcium-dependent secretion activator 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101845091</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825522.1">
        <property type="nucleotide sequence ID" value="XM_035969629.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845091"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01234">
        <property type="entry name" value="PH_CADPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057457">
        <property type="entry name" value="CAPS_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25341">
        <property type="entry name" value="C2_CAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="365"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="510"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="15">
        <location>
            <begin position="920"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1259"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035825522.1"/>
        </source>
    </evidence>
    <sequence length="1288" mass="147263" checksum="3DFBA7A2DFCFFAD8" modified="2025-10-08" version="1">MLDPSSSEEESENGTIEDGDENNSDVLSLPSAEQRSLSASGDNLSVVGGHSRSNSIRPSSPSPSLVSDRDKIDDFDKTEREEEERRRRLQLYVFVMRCIAYPFNAKQPTDLARRQTKVTKAQLQTIKERFHAFLNGETHIVADEAFTNAVQSYYEVFLKSDRVANMVRSGGCSANDFREVFKNNIEKRVRSLPEIDGLSKDTVVSSWMAKFDAIYRGDEDPRKQPQRISTAASELILSKEQLYEMFQNILNVKKYEHQILYNACQLDNADEQAAQVRRELDGRLHNVEMMARTRRHPKFVVKEMESMYLEELKSSINKLKSNLESLPVSKGGADSKYSLQKLKRYNRPAAQTSPTRGSFRTQHSSLSKLDINEDNDPGLSKMDVVLTFTLEVHVIEVKGLKSLAPNKIVYCTMEVEGGEKLQTDQAEASKPAWDTQGDFTTTHPLPVVKVKLYTESSGMLSLEDKELGKVVIRPTANSSRTPEWHHMHKAKNFPDDLRIKIAVRMDKPQNMKHCGYLYALGKTVWKKWKKRYFVLVQVSQYTFAMCSYREKKPDPTEMMQLEGFTVDYCEPLQDLDGGKNFFNLVKEGDSLNFATEDESERTLWVQAVYRATGQTHKPVPPVVQTNKISNTQISRMQGDADRARKHGLDEFVIANPCNFEHHELFSILQTLTLDYRLGDAYTCLGWFSPGQVFVLDEYCARYGVRGCHRNLCYLNDLLERAEKGILIDPTLIHYSFAFCASHVHGSRPDGIGTVLQAERTTFDEIKERLRVLLEKQITHFRYCFPFGRPEGALKATLSLLERVLMKDIATPVPSEEVRQVIKKCLENAALVNYTRISEYAKIEGRKKGAGEVLGEDIPPKKKLDDIMHLAELCIEVLQQNEEHHAEFVWQSTNLQKVKAFAWFSDLLVEHAEIFWSLFGVDMNSVLDAQPPDTWDSFPLFQLLNDYLRTDENLCNGSFHQQLRDVFAPQVVRYVDLMESSIAQSIHKGFEREKWEPQGNGCSTSEDMLWKLDALQSFIRDLHWPEEVFAEHLDHRLKLMAADMIEAAAKRTLKCFEVWLRKGGKSTDYLVFTEICTMMNVIIDCKNKALHLCALDHGQNMHQYHTKIDESLERAQIEMARCLIDKLLSVLESILSKLARYDEGTFFASLLSLTKPVNELGKAYVDFMRGNLDQMRNKINDELYTLSLFEQWYTGQMKMICDWLTDRLDLSLHPYQLTCLMTINRKCFSDFELQGVPDNTLNSKTYQTICSRLQVEEATQSVTQSEGSGRTFLSKPASSSTAASGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT02</accession>
    <name>A0ABM1VT02_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101851265</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825544.1">
        <property type="nucleotide sequence ID" value="XM_035969651.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851265"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="244"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="405"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="495"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="593"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="837"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="932"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="860"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035825544.1"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111890" checksum="64CC1A10A3EC35FA" modified="2025-10-08" version="1">MSCFRGQMHEYREIAIDRFDGGNLRCTAFFLSHCHKDHMVGLSNPAFLDRLSSRKNIFLYCTEVTKLLLLADEEFRCLKNYIQVLQVGFSQPVTVQGINSSEDDYIINVTPISAGHCLGSVMFLFEGHQGTSLYTGDFRWELNQASKMSALHINESVKNIRSMYVDTTFCISEAYHIPSRVQCVEATVGLVSAWLTNSPLHVVTISCPARYGHEHLLVELARQLETKVHVLKWKSDLYAEIPGLESYFSADPNETRIHACSSKGGFPSASRLPCGHHPVKGEKFKIMNIRPSTMWFTSEKTKASAEDLVVAPATQKGLHRVCYSMHSSYSEIRDVVSYLQPERLFPNVLPQSDATMSTVQKRLDSFLKYPHKLRLKTTDCSSGPTFLGELRTLRTVKPFGNLPGLLDTQASDSPDDLVFSSPDSPLKRPVPTAKNPRGVRNLNSLFGKQASPESPKSSASAVHSSYEGSDRNEEELDIAIEDVEAPKEMDCLCSGKEEEKREDEKNEDEESFRLYVSGESDVCDDDEEDEQENDFSEYKIQFFQIADEVSKSVLKSSKWDAGSSSFVDDLSKGKVESSGKMKRKFHVSIDTQCEKSNTESKCSNETDVCKVSDGDHEEKEPKKSDHVSLQTVLTLSERKHPDINEDLNSSVQEESDEDFIPNSQEGKDLSYALCLGRRDSPSLPQNELAEEVEDEDSSHSEPLLVNSYSSKKGTDGTLGDVCKHSDKGNSVNCPDEDVISIKSSEEMNDSNATQSYNCDFLTVKESFSVTEEAAFTPVKDKDEINKSLKESSSPLVVHSEVDKSCSSTVQVEEENCFNCEKRDVHVVSSRKTKLKENDYNCNKSGAKTISGNSNSTPQRLSERALKPEGLGERQDGEKYKGVVRKKSLLSSPPPSSSSLQACLRERSVSVLVSEDVIHVDDAQDDDIEYLFDEKPETEQNQEAVNGSDGWMSKQSNQQKGIPHTFSLKRRSSPVTCGKRTDKKQRKVTGGMPGQEVVDLTDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT28</accession>
    <name>A0ABM1VT28_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">RYamide receptor isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16" type="primary">LOC101847421</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937781.1">
        <property type="nucleotide sequence ID" value="XM_013082327.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825568.1">
        <property type="nucleotide sequence ID" value="XM_035969675.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825569.1">
        <property type="nucleotide sequence ID" value="XM_035969676.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825570.1">
        <property type="nucleotide sequence ID" value="XM_035969677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847421"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="141"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012937781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035825568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035825569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035825570.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="63075" checksum="4696C2D74F1256E1" modified="2025-10-08" version="1">MPRPRTDAMRDQSQPSTGTVTGAFTDVSVAVYVPDSVKTGYVEKDVSIAKRLGTNLESHHHHQHLDTRLETYVEQLLPKNFPENGTNGSLFFSENGTYNDSELVTVPNDYGEKEQFDKAFREAQVAIIVLYTVLCVVAVLGNSCAVYVVISKRKMRNVTNYFIASLAVSDILMAVVCIPFSFVANVLLDHWPFGSTLCPIVMYLQVAVVFQNAYTLLAMSLERYIAIMHPFLRRLGKRRCLQIVALCWVLAFLTPIPTAVTSRVEPMQFGENNETRDICFEHWGSETQRFSYSLTIMVLQYFVPLLVLIYTYAKIVHVIWLKDLPTPAELLNPNEKEKEAKPKDTAVDPRKKAPGTKTFQRQTWRIIKMMLTVVGIYGICWLPLHAITIAFDVDNSVYDAAYMRVVWIASHWLAMSSCAYNPFIYWWMNPKFREGYSSVFSRMRSYLCCCVCSSSSDGKDFVPSSDNRRCIFKCGNNGSSNLCASRRQSATQMVEFTGVSCDVTRADLAREKVMAKEHHALSNISEVAENGTSFNSSKRFNMSNGNDDETPFSHSLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTG8</accession>
    <name>A0ABM1VTG8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate sulfotransferase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825710.1">
        <property type="nucleotide sequence ID" value="XM_035969817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852545"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825710.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="47575" checksum="01491B9CE6131351" modified="2025-10-08" version="1">MINVLKRHLCRAWTNKRAHVIGAVLVCVFTQILCLIVFRSELFTTFERHKYSVEWHEESNDTASKELEDMPITPKRPMKILLLGYMRSGSTFCGDILQANPDVFYVYEPILYTWDHYMPGHTNPSVRRIKASFSKTRSYIPEPLEFLDYMYRCNLTAENVGFLTNVKNSHAFASEKCSGNSTLYNAIHEANVGPCSELVLKRCKAAKSILLKVVRLSMREADKFLEKDPELKVIHLVRDPRGTLLSRMHFTSKLTGEMHKNYTNICRRILDDIQVSKIISGKHFGRILTVRYEDLAQEPFVFFRKMYSFLGLKYTPSVEQYIQKRTSIEGLSAYGKPLIKSTFRKDPFKTAYQWRQELPFQLVKKIDHACKGVYLSMGYRTFSNEEDLRDMSISAKDATYGKGRMTLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTS9</accession>
    <name>A0ABM1VTS9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trichohyalin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825821.1">
        <property type="nucleotide sequence ID" value="XM_035969928.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849462"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825821.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="63739" checksum="9B71D21A628D5447" modified="2025-10-08" version="1">MTEVLRNTSQNFDGAEKKKVLEQVFAQYDANGVEELTPIQVQILHGDLRMGGISLPQVFASVKYICATNNCHISELYDLIQEMDRRYFLIQDFRWEFSFLDREQKQSITVAQAKWFVQSVHGRFFSPGKWSNFVKSRAVPGSGVTFAEIEVMLCDIPSKQILEEEERERERLQKERQKRKEQEAAAAKAERMRRQQEREAAKKLEELENKKAEEERLRREREEAIREKENAERKLKEDEEERERLKRLEEEERRKREADENLYKDAELHKEAAEKAEKDADNELAKLESEKDGADEKKRKMIEEEEERQRKLKKDNKNKRIRYQLKVAIKAKDKYQLEFSMTEFKNAKLSDDDMDYEKAKRLLRQLSAKEGLQKAMTKREIEELDRAMTFVRKHGLEVELASEMMDANKLLSHLRRLERIRHEILELKQSTVAEIRSYTSPPLIVHTVMTATFLLLGHKEGETKDWKAVQALVGKTGKESLKRRCLELDAKTLALKTAKKARKLLEKYELDDVRDISAGAATFFVWATAMIEEAFALLEQESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTV2</accession>
    <name>A0ABM1VTV2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thymidine kinase 2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106010962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825844.1">
        <property type="nucleotide sequence ID" value="XM_035969951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106010962"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF24">
        <property type="entry name" value="THYMIDINE KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825844.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22291" checksum="2BADD93075DC3554" modified="2025-10-08" version="1">MDKTKDHFVTVVEGNIASGKSTLLDYFKDNSNCEDLVHKDAARWGATTQSYIQLTMAQSHVRSQTERVRLMERSLFSGRYCFIDNLLQSGKMTTIEHSVLSQWHDWIVDALQIKVDLYVYLRTDPRVIPDRILKRGRVEEKDIPMKSIESIHGQHEDLFIRGTKVYKPNVLDFNGELSTWRDRSLWPSFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUC4</accession>
    <name>A0ABM1VUC4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemagglutinin/amebocyte aggregation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826016.1">
        <property type="nucleotide sequence ID" value="XM_035970123.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850006"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040:SF1">
        <property type="entry name" value="DERMATOPONTIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040">
        <property type="entry name" value="DERMATOPONTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046058121" evidence="5">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826016.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21422" checksum="93BE3F746323EAD6" modified="2025-10-08" version="1">MELELTVVLVVLLPLASGVSWMTDYDQQFTYECPEQHYLQTIESVHDNHKEDRVFNFGCAPMSTFFSGNELDSCEWTGYVNDFDALMEFQCHNDYIIAGISSYHDNGKEDRRFKFQCCKPGSLVAHACSYTAYINTYDHVLQYRVPDGYAIRGVNSIHDNGKEDRIFKFDICKLDKLQGPIDGEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUN1</accession>
    <name>A0ABM1VUN1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101851955</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_035826123.1">
        <property type="nucleotide sequence ID" value="XM_035970230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851955"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20435">
        <property type="entry name" value="Tudor_TDRD12_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655:SF2">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="730"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="1131"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="16">
        <location>
            <begin position="1489"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="18">
        <location>
            <begin position="1972"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="1131"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="220"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="318"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="408"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="489"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035826123.1"/>
        </source>
    </evidence>
    <sequence length="2149" mass="241700" checksum="F34552E059916E2E" modified="2025-10-08" version="1">MGEKSINLKIIQVTNPWDFLAVKTRGGMTSSQYGDGFEQMMKELHQYFDLTAGQGCNPHKPVQGEICAAQRRESNKWQRVRIEEIMKTARGQQARCFAIDDGEEFMTILLRVQWLPSKFKEFPAQVRRCSLWGVQPLSMIVSEADSGLVARNRPCLKWDPSAVLMMRKWANENPECQAGIMDEDSENILYLRLYFQTGSGLVCFNEKLMEEEYAVSIEPTYESGKHDSKLARESTDQIQSERSTPQRQDLPLSSSVSALSSKTVEPPDPSDDMPPLLPVVNSSETSSQSHTIQSEVCSLAMEENVKSFFSQAEEVMKHSSPEKYNEQTQDIHSLERSQYSSDLEKEMMSPPCGRRLTESDNVSPSGRLDLPGSGVTSPTDVKQPSREKERPLILGRGRGALLQLLAETQKQKSPGSDFESLKSPVKISTDSSKQTLLDQGDLIGTSDQVPVPSPVRPHSPVKPISSEHKSGRGAATVDINCNAKLPVAASPTYSPHSSSPERGTAAVFSSSPVKNSSPLSLRIGARPKVSSHQTTASMESDSRRSSVQVSSDMYESHDPAAVSHHQSSEGEDPHRQTSSTSLDKSERRRLKYGDSSDEGSPSSDSISHLDPGVRLRYRNSIDPLVETLETKEKSAEIKLSKDKYVGQIEGQRLLEMLRIKSGQHIRDNTLPMTAPPDKPIPLPFLGVMAHGKNLPTIHLNVADVPFKSSVIKLMLDKDCEHSQGIQGYVWPAILACRHIVGISTPKQGKTMAYVPALVSHLLDQMNYIELQKGKGPQALIVVPSWKKAREVYELIEQFTGASLRRMRQLKSIVLYAGGTEDNESTTTELFRGCEILIATPNSLLRALADEKTSLKRVCHIVLDDAEILATRFSDEISDLMQQYKIVLNSRKHQTVPKQIMIFGSRWSSAVDEFRAKFTKEPVIVFSSRVEAAVYGGVKQVVKMSKSDKKLTTFCGLLDSLASTSAGEKVIAFSEHVTEAVDMFKAAKSRGIYSLIIHERLESEEMIEEARVLWLEASRSKQLLLMVCTDRCCQDLAVTNATAVIHYGLPSSKTKFGNRLTCMLDFFDDKTAPPQLNHNSRPRPEPVSHVIITEDRADRAQSLFEVLQRCKAEMPPQLQNFLQGFQMGLEKDERKPLCPFLKAFGNCINCDRCEYRHILMPEQDLKTGEVTSNSLPAQGEVKVQIIQVVNATCYHCHLVEHVSQTDNVKTDLRAQYQQLVLHMTLFYCKESNHVPFVPSQDCYSDGLCAFKDKGDVFYRAKVVETWEGSASSPMRHCRVWLVDAAVHAEGTVDQLVQLPKELAEIPYQAVEVYVCRIKPMDRDSEWTDKADLFAHELVEGKELTGRVVLRLGVTMWLDPLVHQVFLKNVGKANNLVIRQELLANKLATPNPDHIQQLYKLCRGKTEIPEQIMRKYFDYCLEIELMQETLTSNQEFHAVNIGSIISPELFYIQKWDTIEELESLENAIAEQMESDGSTDEEETSKVDAEMKMEQGSVCLAQSTDDKWYRGKIISECVDDKLEIFFLDYGDREWVPSDLVKPLPREFSQLPCQAIECQLSGIKPKGEEWVPAAIDVMCDLAYYVDEEKKQLFAKVLRRTDPELSMGQKLEIELFDTNAGEVRFSQELVWRQAASCPDQSPDVKVLLGKPALKNQLFFNPLDKIPYLCAKIYWSENEEESISQAQELYDLLSQRNDGWDSALEQRGVLLDAVKVVGYLGCVRTHGLLLQALTSCCGDSARVSEICISENLIRHLVYCLEQVSRPQVQLQAVQCVTKLLNQKSFVEACSSSQLENTLSELLKRHQKLTLEEEMVKYVCKASAQLVQCSDSGVCQELKTLEVVDLIWSSVPMCTSDDEREPWLELLGALAQCKSVHPFILREGFLGVLLGLLSNLMSPKCLYHMLSTLQCLVYDNRKNKRVLLEHKLLIILNDMLDRGLKSPTLEQCQELQAAMTLQLPQQEVLAGVPAHRSDAVDKAVSPHVTWIENCFRVVLTVSIRNASINDFHIYPNRIFVSAWSEGILYELDWELFSNILPNKSTVKPCPGQTNLFLRKEIKGKWGRLLKQKIKPPCLSLDFEKVYDSDEEEVDDDDAVHLAKEKGSFAGVPRVRIPKPHLCDSDEESSDALVIYSNSDDEEPVIDMESFLRDNNYLQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VV94</accession>
    <name>A0ABM1VV94_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC118477881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118477881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826336.1">
        <property type="nucleotide sequence ID" value="XM_035970443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477881"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="3">
        <location>
            <begin position="40"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826336.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15213" checksum="2B3828535C1A7D5C" modified="2025-10-08" version="1">MGATKEGLLRRKIQIVNLPVFTAIFVLVLCNGVVTRAAVELMKNPGFENGVTSWSHDGFSMVTTTEQVHEGRVAVKCTGRTQSWMGPAQDIQISRGKHYVFKSYIKLINDLPGRMFQKAGVKISFTLKDGVFFMSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVD5</accession>
    <name>A0ABM1VVD5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CLIP-associating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826377.1">
        <property type="nucleotide sequence ID" value="XM_035970484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845174"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="305"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="897"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="1260"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="849"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1239"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1146"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1247"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035826377.1"/>
        </source>
    </evidence>
    <sequence length="1503" mass="166014" checksum="0FE94AD9DEB59AFD" modified="2025-10-08" version="1">MASLHDFMDSVVTQDTKRRLQTHGELVPFLSDPRSSLDLADFDSDQFIEGLTNWVKSSNFKVSLNGLEVLCLMVDRMGEQFKPHVTTVLPPVIDRLGDAKDQVRDMAKQLLLKLMMPASTPQYVFDRLGPAFQHKLWHVKEGALVTLQSTINRYGARCLQLSKIVPDICRLLDDPSPQVREAAVSSLVEIYRHVGDRVRNDLKSKGLSQQRLNQLYAKFDELRVSGNMLPTADITPSRGSSSSHHDEPDFDFLKPTAGKPLQRKSSSVSSSGPRRTTSSASAGGGSGAVDEELFIKSFEDVPNAKIFSSRDVQEQIMKVKEVLSDPNVTWEKRIDHIKMVRSLILSGAADYDDFFQSLRMLESAFILVVKDLRSQVVREGCITIAYMSQQLGTKFDHFAEAVLPSLINLIPNSAKVMATSGTVCIRFIMQFVHTNRLIPIVTANLTSKSNIIRRFSCEFVNQILHSWPTHSLEKHIAILQDAIKRGISDADSEARAHSRKAFWGFADHFKSQADALLNSLDASKQKMLQGEISNSSSSSSLNGDHSRPRSRSRAASEERSGYGGGLGHGPSTLRKTPQRISSSKSDAGDVRIITPRARAASSSSNYSNYSSNSSSSRYYSSHHQHYNTIGHPARQRAASSVGGATTPRGHASSTSGPAPGPSPYNNGSSSLEPPGPLPRSVSASDINSSLRTPRPRPTLLSAARMAKGSTNSLPRQKSHTALSSTAAGTSQLLTPDRAGRAKPSPRVCQSQPNSRSNSPSSARRQLSYAKHTPARVDSGLGPRRSRIPQGSHSQGASREASPARSFRAGQERRLSSSSKVSSGRKTPVLSQRVLRHGSDVEDALHDALAKGPQRHRYDHYDSDDAASETSSVCSERSHSSYGGRTSESRGRTRSFSSGYGATEDMHSIISQLGSSSHLDRKDGLLSLQHLLRSNRSLSRVELKKVSEMFTRMFHDPHSKVYSVFLDTLIELVYLQSADLGDWLHILLPRLLTKAGSEMLGSVANKVQKALDVIRDCFPYDQQFNVLSKFIVDQSQGHNLRVRVSVLMYLHSLTLSMDPSDFVNTMDARLAVSKVISSTTEPKNADVRKAAQSVLIALFNLNPAEFSLLLSELPKTFQDGATRILHSHIRAANEGMGDVLSPRNVASPQGQNRSRPPSRSSQGHPDDFETENLNPEDIFNSIKKTSADIQSLSISSKLDPYEEVKKKHDFPSQDSGIQDLRMDSPDGLDHKRGFFSYAHKSGAGGQGPSPSGPMSAGPFSKADTATSSEEVGKIICDVLEELSNHNERVEQRKNAMQCLQGLVDKGAVSESQLEEHFKSLLLILLETLGDTNGDVKVMALKCLQKMLQKFPRRFEDYAELTILKVLELHKDDSYRDVPYAASEVEDTLVQALSPEQNFRILTPIIQTMEYHIACGATQMMTKVVEKMPKEMLETSLPNLIPGLFKNFEHMQSPVRKASCFCLVAIYMRVEEALRPYMDSLNSHRMKLLNLYIKKRKLEDAKQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVZ6</accession>
    <name>A0ABM1VVZ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Inactive rhomboid protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101857579</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826587.1">
        <property type="nucleotide sequence ID" value="XM_035970694.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826588.1">
        <property type="nucleotide sequence ID" value="XM_035970695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857579"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF3">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="523"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035826587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035826588.1"/>
        </source>
    </evidence>
    <sequence length="735" mass="82136" checksum="BC656CA7F44DD296" modified="2025-10-08" version="1">MSKMDSSNAGTQSVPSGAVSTTGSQTKMGKYRQKAKKSVASFFGLVEDDVKNNQRWEHRRVRIASQMGKGVRDEYVTAPPMDMMDAPNIIDPLRTSRQASRMSTMTATSAAGQARRKKSVLQMTMNGISQLSSARKDLRKKSFKGQSFPPGSIHSTEERPHPGDDFSLVDDVFYDEHPASSEGGGRSMDLAGGPSAPGWRRRPPQALPSTPGVDLPDGPDFGLKRIKQKVVDSVMNRDKRTVGMGIVGRLMRRRLKSNIMTKDVRKQLDNLDDHRPYFTYWVTFVQVVVFIVAIAVYGIAPIGISTTEESANVKMPNLAIQTETHVERDNLWIGPRQRDLIHLGAKYSPCMRVDENLNTALSYDRHAERGSACCIRNDGGGCRQTVKSDCNDILSRWEKWTPSNPGPNGRLSGTVCGQDPRYCNKPSSSPPFEWPDEITQWPICEDTAKPNQSLASTTNEHMTCDILGRPCCFGIQGECIITTREHCDLKRGFFHDEANLCSQVDCFEEICGMIPFANPEKPDQFYRLWTSLFLHGGLVHVAITVLFQMYIMRDMEKLMGAIRVSIIYLGSGIAGNLASCTFIPYQVEKGPSGSQFGIVACLLVEVIQNRKMYRSPALALVKLIVPLLFFFLLGLLPWFDNWAHMFGFLFGFLLAFALMPYVSFGKFNITRRVVTILVSLGMAVGLFTLLIILFYLSLLSECDWCVYLNCIPFTADFCENMEVKLKTNSTYSAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW22</accession>
    <name>A0ABM1VW22_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC106010976</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC106010976</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940192.2">
        <property type="nucleotide sequence ID" value="XM_013084738.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826614.1">
        <property type="nucleotide sequence ID" value="XM_035970721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106010976"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940192.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826614.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11797" checksum="30020DC9D407C154" modified="2025-10-08" version="1">MLARWLRTQVQVHQRNLHGLSPGEGQPNRWTLTRSQVQVYPGNLQRQRPGEGQRNRWTMTRSLVQVHPKSLQRHRPGEGQRNPWTMTRNQVLVYPGSLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX84</accession>
    <name>A0ABM1VX84_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012473</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827026.1">
        <property type="nucleotide sequence ID" value="XM_035971133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012473"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827026.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34741" checksum="382B167C9D6210DE" modified="2025-10-08" version="1">MYSVCFLPFVYGVGIIVLCGELGFRKKLRSLISSPYVSSILVAAVPWIAGLILILPLYLAGFDYVSCSYGDSMTGDRQRAFYVVGIVLPSALAVIFALMTSCWKGDAISEYCDSPQSQGVVFSQAVTTHNAQGFPQQQYYPGPPQQQYYPGPPQQQYYPGPSQQQYYPRPSQQQNYPVPPPATAQQPYYPASQPPAYVSGPQGPGLKQPAYPPQPMPPTQAVIQTPVSSTQPPSNQQLLAAVRNEQSTLVLVAVLYAVLSLPFALFILGYNLNKDHVFLDPIPQTMLSNLFQWMLYLRSIVTPIVWIIKEKTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXW1</accession>
    <name>A0ABM1VXW1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Laminin subunit alpha-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC101862601</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827254.1">
        <property type="nucleotide sequence ID" value="XM_035971361.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862601"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009254">
        <property type="entry name" value="Laminin_aI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF436">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06008">
        <property type="entry name" value="Laminin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045114369" evidence="15">
        <location>
            <begin position="31"/>
            <end position="3302"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="19">
        <location>
            <begin position="36"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="470"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="18">
        <location>
            <begin position="539"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="807"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="919"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="971"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1018"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1066"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1116"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1164"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1211"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="18">
        <location>
            <begin position="1339"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1575"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1625"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1682"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="2334"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="2533"/>
            <end position="2710"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="2717"/>
            <end position="2887"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="2948"/>
            <end position="3120"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="3125"/>
            <end position="3299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2902"/>
            <end position="2948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1832"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1928"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2082"/>
            <end position="2128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2309"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2918"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="971"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="973"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1018"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1020"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1118"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1137"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1183"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1213"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1594"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1652"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1682"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1684"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1703"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2495"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2683"/>
            <end position="2710"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2860"/>
            <end position="2887"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="3272"/>
            <end position="3299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035827254.1"/>
        </source>
    </evidence>
    <sequence length="3302" mass="363031" checksum="70D6581FB81028A1" modified="2025-10-08" version="1">MGKWTLQCVQRASVACALLLCVLFIGQAQGQRSDDDLSGLFPVVFNLATRARIQANATCGLNEPEVFCKLVEHVRIFPAENRHCDICDARSDNQAQSHPIQYAIDGSQKWWQSPTLTNGAGFNHVSIILDLGQIYQIAYIIIKAANSPRPGNWILERSLDGETYFPWQYFAMTDKECRMFYGIEATRGVPTFLRDDQVICTSRYSALNPLENGEIFVSLVNGRPGVFQPSKVLLDFTSARYVRLRFQKIRTLNADLMSFSSIDPDSADASVTRRYYYSVKDISIGGQCICYGHATFCRRHDTLEDRLQCQCLHNTAGDNCEMCLPKFNQKPWKVGGIQGLGCEECNCHGKSDECVYNATVDANKLSLNMTGSYDGGGVCLNCREYTTGVNCERCLPGYYRPRGMTPDMRFPCRQCNCQETQTSTSECVLDDSRVDEGLEPGSCICKEGYSGPGCDRCAFGYFGFPNCRPCRCNAAGSRDPDNCDRACVCKVHVRGSRCDSCEPGYFNLEQANPEGCTKCFCFGVSTVCESVSWGLSRVDDYSGWVLSTLGPGGLTLLPRMFGGWLEAKTYLLKVDAIDPRSYSQDDIHYWVAPMSYLGNRLSSYGGYLTFTLKYSLDDQLSGGYHLREPNLVLEVSFITFRRYRLLFICPPSFFLDLPVCYSPCPSTNNNLLFNILIYLFQGSNLAITTDKEYLREEMENKVRIRLHESGWFRLSDRQPVTRDEMMTVLYSLSRLLIRATYHTAQETVFLKNVYMDMASPLVMDGSSLPSVEQCRCPQGYAGLSCESCSPGWRRVENQLYGGRCQQCQCYGHASGCDPVTGDCMDCRHSTAGARCDRCLPGFYGDPRRGSPDDCKPCACPLTTGNNFFAERCVARPTLEDRDAYECVNCQEGYTGDRCEMCASGYYGNPGTPGGSCRRCMCGGNIDMSLPGSCNNVTGACTRCATNTEGEFCERCSPGYYGSAVNGDCRPCECSNSGSRNNECNARSGQCECKERFTGRRCNKCERGYGNVERGCERCSCDRQGSQSSECDPVSGQCRCVDGVVGLNCDACAEGYYDFSRRGCKDCDCYGPGTNNTVTCDPYSGRCQCRPGVMGRQCDSCKRFHYGLESGEGCKDCACDRTGARSGVCDPQNGQCECRPGVMGRTCDKCQPGFYGFSRRGCEACEPCNKPGHICNPDTGKCECPPNTEGPNCEVCIRDCWGFTKDQGCKPCNCSQSGSASQQCDPLTGACSCLEGYQGYSCDQCLVSFYNFPDCTSCGCNETGVISDTCITGVCECDGMGQCFCKVIIVGSDGGLLCCDLREVKVGLHRCRPGTFSLDGNNPKGCTECYCFLRAQQCMQAPYVWKEIDLPSMSAEFVPPGAGGEPPFKRFGYHVINSTKTEVTSELSSSPLYFALLSDALPSDMTLNYGGKLQITHYFEGPSEYLRPEDAAPLAVMVGNGIQIVSQVSNLEPLNPVPFEVVLHEDMWQLPGQVTPITRRLMMVVLEKVQGLFVRAVQNGRAQYSEVGPIMIERAVPPASAPPNARPALGVETCDCPDRYSGDSCQNPGPGYFRVVPDGTTNIGVPETVIGQVKPCQCYRHSEFCDAETGQCLACEHNTTGRQCELCADGYYGVATRGTPDDCQPCACPLPIPSNNFSPSCVGGRNGMMCTACIEGYTGLRCENCAPGYYGNPQTVGSKCLPCNCNPQGSQGGDCDVLTGQCPCLPGIEGLSCEACSDPTYGVQDGQCISCYDGCTGILLKDMEELAASLVNINFTGAVYPWDRLNELSDEGKALSESLRALEAAGSDNLKDMKESADTYNQIADKLIHRSNTTCEGELSTTGGIACRTQKSAEQVKNNATDLEKVIDQLFKDIKKSVDELNKLINDSLAGQGGTGGQLDEQLKKAQKILDEILDRDFSVADAATQTENMRAEKLSESIQDLIARNFNVSMVEEDLNDVKDRLNDLINQTKGASATADNALELIRNLTDLLNEMKRIKEEIDKLRNDSEDYIDDAWDLIYKADSSLLISTGENDLLARAIDDLYKRVTGLREAMPRLQDLYQRAVQHALYLRGQTEEMKRLFAKTRDLAKDAVTAAKAYQSIVDAIAEAKKSAEKALQDAEESKKIAQLSDLKKEVDELMRISNQQLREADSLLAEAKGLLESLGDVKDDLTEAGEKHGNAKDILEEIKKKLKLLPENFRDSLDNIEKRTKAAEKTAEDAIELINKLNTTALMEKMNEMKNLDLSAFRFDIGSESKYLFCISVFLSNYQLLIFFLHPSHCHCDVHEKSYSSLFLVILLVERVKDAGKDIKKLTDREKDVDDKASAAARKVSNVHDDLEKLRAKIINARNRVNDMKMSLQADGQCYRSYPSSLTPSSTNELRFGFKLDEAPNSDMLMVLLLQSPQAGGKEFLAAEIKDGKVRFSWESGKGLGSVSHGRSLEPQKWYKVVAKRVGSIGQLKVWSLEESTEKRTNEEVASAGAGCSLLNLNEDSSVFLAGTSNLHPIPAGITRENFVGCLGEVSIDNSKLGVYNFKTNEPEHCTACKQIPLVELGDGKTYVFNGRGFARFEVLGGYSSSRTKVELEFKTFWENSTIFFVGNEELGDFCSIELVNGRVQVKFNMGGNSKGSGITANTYNSNQWTKVTFDRKKLQAVLIVNSEKIPMSASGPNSGLDLQGAPMYYGGLPTTFSLSKFQGLTQTRFFYGCMKGLTFGSLPPEDDTSVFVNVQTSSGCRENGIHTVGFRGDGYLTLKSEYIGFNKQKNDISLTFVTKEKDAVILIARDIPGENYYSIALVDGRMEARIRSDGNQPVGIQAKERFNDGVMHCVSLIKDGKIIKLVVDDKVLGTDSALDVSFFNGGDLYLGGSPIDVDDIAPTSIKLDGCISDVIANGKLLSMSDAKQYMRADVGRCHLTTNMNEPVVVPKVDEAEEEPTEEPTIPTSSNLSGNTPVSPTSVPTSCASEGNPAQEDDAKSVANGATFFAEISKVKKKELARRFDFTFDFRTYYADGLFGYLTNADKSFYFGIQLRDGKLEVSYVYLGQPMVLRYNELLNDGKWHSVEVKKKGESVSVSYDGKTAKSDLIDQRLDIKLPLRLGGPAKPEDFTDYNVDLVTHSIRGCIRSLKVSGRGVNITDTQVIQDVGGCYKNVEAGAYFGGDAFGVITDDFDVPKKMTITLEFRTTSQRGVLVSSSDGSKFGFTLELDEGKLKLAVINKNGPFRVESNNDKIFFCDNKWHKVTAVLSDNALTLSPEGLGDSRLTSRLPLGDIGLKSPLFVGGFQDSFTQVASSSADNFIGCIRGLVIDGSLVDWYKLILSPNIRKTACPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZN7</accession>
    <name>A0ABM1VZN7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012895</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827880.1">
        <property type="nucleotide sequence ID" value="XM_035971987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012895"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF62">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="149"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827880.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="65622" checksum="F3CDCAF83EFD7C9E" modified="2025-10-08" version="1">MVEVHCGFLTVKISGLLRAKSYPNFYCVLYSGRGNWAPRIDLYENKEASRPPGNCKKSLFIEDAKWIPVDVVDPAFALDVKGKTCTFFTASQKERKYWAVALCCLSGNLFDTRHIVYPSLGMKSDKVSHLDEEYVVEQNVLYSSSPASFIKKFDVFAESSEGCLRLGLHGAYKFVLAPVVLKLCQFEDETDVSEWPYKFLRDFGHSKHSFFFNAGSRCQTGAGYFNFHTTQGEQIVQAISVLTHRMCDADDDTSLTPPSQDSITPTSPSRTKLLVGKQKSDTVSPPAPPPKVNVGQSHSHPSDANQPSNKFKNELSKAIFQQGGEQKRGSVDSSLSSDSTQSSSKTDKTKSQLKKEQKNMKKEARKAQKEEEKMRKKQKEDERQRKKAEKSKPPEKSKLQEKSKLQEKKPAKTVPVDTSSVNLYSDVDSAYATADSVAQVNTDEHNLGIPNQQDGQVYSEPWGSHPFLKPYPVSQGADYEDDPVDAVYAQPEKKNPKKVANGKNAPHSEEDYEDLDCKFAAPPLVPPKHFDAGDSDGVYAHLHQAQMPAPAVDNVYGVASAIALLNNGENNGGAGSVSRVQQGSYDSTYDTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0G8</accession>
    <name>A0ABM1W0G8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cysteinyl leukotriene receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106013053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828161.1">
        <property type="nucleotide sequence ID" value="XM_035972268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013053"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
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    </dbReference>
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        <property type="entry name" value="7tm_1"/>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="79"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="373"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035828161.1"/>
        </source>
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    <sequence length="583" mass="65670" checksum="C5377AFC035499BF" modified="2025-10-08" version="1">MSERSISLQTMDVTDSWRRHISFTGHQENLSGQEDNVSSLEKNRHICDYLTAASSVQVKVTCVLDMYLPPFLFVFGFVCNVLVILVMRSKFFRKLSTSFYMAINAFTDGLSLLVALPVHYLFVNFPEIFDTLRHSHPICAFFNIFGWGTSDLGILLTVAMTTERAIAIRFPLKANRLCTTRRAKFVALGLVLFEFIKLSHFAFYSKVVGVEVTSRLCEVFRDDPAYVNFTDNIWPWLHVAILALSYSLVVVGNILIVINIRRSDMESTKGGLGRKNSRKDSTSGSRNRQLSVMLVVDSCFLVICTLPFAIIVILISKFNMLPAAEGGKNLAYTASFYMLYLNRCLNFFLYCVSGSRFRAALRGIFTLPSFSASNDNKSNSRERPVSASGRLSVDNNRNTRADRTNNQTVCPLSPSSDPAESQETSSFNTLSNNNIQTEDVSSDLSSDSIYGPEPLSQNSARQGSTFSVHEQEFDRSSRNVSEDNSTHRAFSNKGFVNDSPSFGRKEQEREPNNSDEGERHPTFSKIKINKRQPSVGESERGRTKRTPCKDILEKYQRDFNIHLLIWWSLAPVRGMLLADPVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2Q9</accession>
    <name>A0ABM1W2Q9_APLCA</name>
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        <submittedName>
            <fullName evidence="7">Cyclin-dependent kinase-like 5</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">LOC101857924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
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        </location>
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            <position position="40"/>
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        </ligand>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035828952.1"/>
        </source>
    </evidence>
    <sequence length="1054" mass="116733" checksum="2E8FBFF8761FE6D5" modified="2025-10-08" version="1">MKLDNVMNKYEVIDVVGEGAYGVVMKCRHKENGEMVAIKKFKDSEENDDVRRTTMRELKMLRALKQENIVELREAFKRKGKLYLVFEYVEKNMLEVLEPQPHGVPFEKVRSLSYQLCKAVQWCHSRDIIHRDIKPENLLISKDGVLKLCDFGFARSITGGSNGLYTDYVATRWYRSPELLIGAPYGKAVDVWAIGCIMGELADGQALFPGDSEIDQLYVIQKILGPLPEDQMKVFMRNPRFHGLKFPAVRRPKTLEKHYHGILTSVALEFMKSCLRLDPMDRVPIDDCVSHTIFQTERALDRHPCPPAKSNSGHSSSKRRKTDNSGTQQGNKESTFIQDENKPTEMEISEKLAPEKMDTNIEGENSNGNKEVLINSKYLKQVRNQTTANGSRNALKSAQSSDISTIGIEPSQGFSKPPITHSLSTASAETDIVLSRVAVDRRDKDGENNFHSSDKNSSKNDGGHVFDSDDHHLRQNPVTSVLQESHKKNWTQQLPSTESVPQGEEVPEVRGQMEEDHGISPRPLAAPSGGGDAGKKLMAANLDNRHLSTFADFRSGNILDFSPSGTNTSSHFNAGPTLKLVKGKARRNEEEDEEEGQGRRENAEFSESMDVATTSESRFLKSRNSAHPTEKTARGKNASSELHSDNNVVADKIGSGGANNTQKAAGTYTVSVDAHAIGSSSNSNSNSNNTSTAAVGGQRSGATTSNKLTSSSQVERRKFLNATTQSEIERIKSSTLGKKKARENRDSQIQNAAQPVHTITDKLSDARLQPSVSSDKFLPQSRHVKGRYLESPLDMYESDFGQPAREGRQYGRYPVYNMRADSPSMGPFMSWRMSDGGQSNVYNLVRKKKKKLMQVPEPFEDGRLSPSVNLRNGSRLSRYEVMDYDGGRDNEDAESSHMTPRDGALSQRTLTTTPVPYGPSRAGDGRRAYKQPVSLRHQAAPNTPKDRQVGRLQPLGKNQASTLSSHQQQQHSTSHSSINMGHPEPSSSNNKTYGGMKSSMAGSIMQEEVRGHGARQRQGSLFLEDDLTPRIYAGTLDSRLGRGGGPRSGKSSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I1SKJ2</accession>
    <name>I1SKJ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone 3.4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Histone H3.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858063</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2007-08" db="EMBL/GenBank/DDBJ databases">
            <title>Characterization of histones in Aplysia californica.</title>
            <authorList>
                <person name="Kohn A.B."/>
                <person name="Moroz L.L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EU104714">
        <property type="protein sequence ID" value="ABW86955.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001297415.1">
        <property type="nucleotide sequence ID" value="NM_001310486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I1SKJ2"/>
    <dbReference type="GeneID" id="101858063"/>
    <dbReference type="OrthoDB" id="10013248at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000054">
        <property type="entry name" value="Putative histone H1.5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABW86955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="NP_001297415.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15635" checksum="337A25E1FC399977" modified="2012-07-11" version="1">MARTKQTARMSMGGKAPRKRLATKAACKSAPATGGVKKPHRYRPSTVALREIRRYPSFETRTLSFKHLVREIAKDFKTDLRFQSSAVMTLQKSCVMVLYEAYLVGLLEDISLCPFNAKRLTIMPKDIQLARCIRGERA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q6IWZ0</accession>
    <name>OXLA_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-amino-acid oxidase</fullName>
            <shortName evidence="8">LAAO</shortName>
            <shortName evidence="1">LAO</shortName>
            <ecNumber evidence="3 5 6">1.4.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Escapin</fullName>
        </alternativeName>
    </protein>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="J. Exp. Biol." volume="208" first="3609" last="3622">
            <title>Cloning, characterization and expression of escapin, a broadly antimicrobial FAD-containing L-amino acid oxidase from ink of the sea hare Aplysia californica.</title>
            <authorList>
                <person name="Yang H."/>
                <person name="Johnson P.M."/>
                <person name="Ko K.C."/>
                <person name="Kamio M."/>
                <person name="Germann M.W."/>
                <person name="Derby C.D."/>
                <person name="Tai P.C."/>
            </authorList>
            <dbReference type="PubMed" id="16155232"/>
            <dbReference type="DOI" id="10.1242/jeb.01795"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>PARTIAL PROTEIN SEQUENCE</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>LACK OF GLYCOSYLATION</scope>
        <source>
            <tissue evidence="3">Ink</tissue>
            <tissue evidence="3">Ink gland</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2006" name="J. Exp. Biol." volume="209" first="78" last="88">
            <title>Packaging of chemicals in the defensive secretory glands of the sea hare Aplysia californica.</title>
            <authorList>
                <person name="Johnson P.M."/>
                <person name="Kicklighter C.E."/>
                <person name="Schmidt M."/>
                <person name="Kamio M."/>
                <person name="Yang H."/>
                <person name="Elkin D."/>
                <person name="Michel W.C."/>
                <person name="Tai P.C."/>
                <person name="Derby C.D."/>
            </authorList>
            <dbReference type="PubMed" id="16354780"/>
            <dbReference type="DOI" id="10.1242/jeb.01972"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2008" name="Antimicrob. Agents Chemother." volume="52" first="4455" last="4462">
            <title>Identification of potent bactericidal compounds produced by escapin, an L-amino acid oxidase in the ink of the sea hare Aplysia californica.</title>
            <authorList>
                <person name="Ko K.C."/>
                <person name="Wang B."/>
                <person name="Tai P.C."/>
                <person name="Derby C.D."/>
            </authorList>
            <dbReference type="PubMed" id="18852282"/>
            <dbReference type="DOI" id="10.1128/AAC.01103-08"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <source>
            <tissue evidence="5">Ink</tissue>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Chemistry" volume="15" first="1597" last="1603">
            <title>The chemistry of escapin: identification and quantification of the components in the complex mixture generated by an L-amino acid oxidase in the defensive secretion of the sea snail Aplysia californica.</title>
            <authorList>
                <person name="Kamio M."/>
                <person name="Ko K.C."/>
                <person name="Zheng S."/>
                <person name="Wang B."/>
                <person name="Collins S.L."/>
                <person name="Gadda G."/>
                <person name="Tai P.C."/>
                <person name="Derby C.D."/>
            </authorList>
            <dbReference type="PubMed" id="19130530"/>
            <dbReference type="DOI" id="10.1002/chem.200801696"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <source>
            <tissue>Ink</tissue>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="journal article" date="2010" name="Biol. Bull." volume="218" first="282" last="292">
            <title>Effects of sea hare ink secretion and its escapin-generated components on a variety of predatory fishes.</title>
            <authorList>
                <person name="Nusnbaum M."/>
                <person name="Derby C.D."/>
            </authorList>
            <dbReference type="PubMed" id="20570851"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5 7">Catalyzes the oxidative deamination of positively charged L-amino acids L-Lys and L-Arg and, much less efficiently, of amino acids L-His and L-Tyr. Has antimicrobial activity. Inhibits growth of Gram-negative bacteria E.coli strain MC4100 (MIC=0.62 ug/ml), E.coli strain C921-b2, S.typhimurium strain AA 140 (MIC=0.62 ug/ml), P.aeruginosa strain PAO1 (MIC=0.31 ug/ml) and V.harveyi strain BB170 (MIC=0.25 ug/ml). Inhibits growth of Gram-positive bacteria S.aureus strain 6835 (MIC=0.31 ug/ml), S.pyogenes strain NZ131 (MIC=0.62 ug/ml), B.subtilis strain 168 (MIC=2.50 ug/ml) and B.subtilis strain WB600 (MIC=2.50 ug/ml). The antibacterial effect can be bacteriostatic, mediated mostly by H(2)O(2), as well as bactericidal. The latter appears to be due to unstable intermediates generated from alpha-keto-epsilon-aminocaproic acid, an intermediate of escapin-deaminated L-Lys, and H(2)O(2). The bactericidal effect is stronger at lower pH levels. Intermediates generated from L-Arg have no bactericidal effect. Inhibits growth of yeast species S.cerevisiae strain BY4761 (MIC=5.0 ug/ml) and C.krusei (MIC=5.0 ug/ml). Inhibits growth of C.sphaerospermum in a lysine-dependent manner. As components of ink, products from escapin's enzymatic activity may play a role in deterring eukaryotic predators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5 6">
            <text>an L-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="1.4.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">85.5 uM for L-Lys</KM>
            <KM evidence="3">120.5 uM for L-Arg</KM>
            <Vmax evidence="3">4.5 umol/sec/ug enzyme with L-Lys as substrate</Vmax>
            <Vmax evidence="3">5.5 umol/sec/ug enzyme with L-Arg as substrate</Vmax>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text evidence="4">Expressed exclusively in the ink gland. Within the ink gland, it is only detected in amber vesicles (at protein level).</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Not glycosylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.2" evidence="3 5 6"/>
    <dbReference type="EMBL" id="AY615888">
        <property type="protein sequence ID" value="AAT12273.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191570.1">
        <property type="nucleotide sequence ID" value="NM_001204641.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6IWZ0"/>
    <dbReference type="SMR" id="Q6IWZ0"/>
    <dbReference type="EnsemblMetazoa" id="NM_001204641.2">
        <property type="protein sequence ID" value="NP_001191570.1"/>
        <property type="gene ID" value="LOC100533346"/>
    </dbReference>
    <dbReference type="GeneID" id="100533346"/>
    <dbReference type="OrthoDB" id="5977782at2759"/>
    <dbReference type="BRENDA" id="1.4.3.2">
        <property type="organism ID" value="390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0044">Antibiotic</keyword>
    <keyword id="KW-0929">Antimicrobial</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0295">Fungicide</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5000093471" description="L-amino-acid oxidase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="513"/>
            <end position="518"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="513"/>
            <end position="514"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P81382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16155232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16354780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18852282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="19130530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="20570851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="16155232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="EMBL" id="AAT12273.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60300" checksum="4F288F95F9B423FC" modified="2004-07-05" version="1" precursor="true">MSSAFLLLACALVISVHADGVCRNRRQCNKEVCGSSYDVAIVGAGPGGANSAYMLRESGLDIAVFEYSDRVGGRLFTYQLPNTPDVNLEIGGMRFIEGAMHRLWKVISELGLTPKVFKEGFGKEGRQRFYLRGQSLTKKQVKSGDVPYDLSPEEKANQGRLVEYYLEKLTGLQLNGGPLKREVALKLTVPDGRFLYDLTFDEALDLVASPEGKEFARDTHVFTSEVTLDASAISIFDDHLGEDYYGSEIYTLEEGMSSVPQGLLQTFLDAAKSNEFFPNNHLKALRRRTNGQYVLYFEPTTSKDGQTTINYLEPLKVVCAQRVILAMPVYALRQLDWSQLRNDRATQAYRAVRPMPASKVFMTFDQPWWLQNERKSWVTKSDALFSQMYDWQKSEASGDYILIASYADGLKAQYLRELKNQGEDIPGSDPGYNQVTVPLKDAILEHLTEAYGVERDSIPEPVTAASQFWTDYPFGCGWITWRAGYHFDDVISTMRRPSLKDEVYVVGSDYSWGLISSWIEGALETSENVINDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAK7</accession>
    <name>A0ABM0JAK7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized methyltransferase C25B8.09</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101861999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089253.1">
        <property type="nucleotide sequence ID" value="XM_005089196.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861999"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="70"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005089253.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32029" checksum="2507D439E478B6AA" modified="2025-10-08" version="1">MDKMHCSTKADGEPDGAYIAAVGFKTGADNYEKGRPSYTAEAVDYVVSEVAAVAKSRPESTGTTKYNVVELGAGTGKLTEVLCKKLPESCRYLALEPSQEFHDTMAAKNLGVDTVVGDAGAIPVEDGSAENVVCAQSFHWFADKEYLEEIRRVLVPGGRLMIVMNWKLFERDWMKPIYEQRKKVYARTGSSLKFLINSKQWQRDIKDSPLFSFKEHLSLPGIEFRGDVEKILQNLTTTSAYNMLPKEEQEAYLNELRQILRSWPGLDLNDLSIPFSSEIYTYIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCJ2</accession>
    <name>A0ABM0JCJ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Apoptotic chromatin condensation inducer in the nucleus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101851697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090562.1">
        <property type="nucleotide sequence ID" value="XM_005090505.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090563.1">
        <property type="nucleotide sequence ID" value="XM_005090506.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851697"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005090563.1"/>
        </source>
    </evidence>
    <sequence length="1214" mass="135703" checksum="E4E5FD83D0D186EE" modified="2025-10-08" version="1">MASEEDSSSSITFKGTPVTELKLNDIKRELERRGLSKAGSKTQLIDRLKAQLLLEKLQQDAAQSSGDELSEGKVPNMALQDDKAGQNEFVRQYLQQQQRNLEIQMEVKKQVEEERKRKSADESSADEANVTKDEGKASAAPDVTSPKKFKDDSSNAPAKEVPKMPRPARKSSRNASKGLNENGQEGDAVTKNQSRSPTPEGDRIRERTRSGSSSSSRSPSPEKSTRGRRGRPRRGRAKKSTGKRGGHQTRKDSPSSSPPSSPGEVMPKKKQRRSTNSISSRSRSRSPQMVSPEAPTRRSSRRVSAAQKSASDQSTMEEVPDDGGGDGLPNKTDDVDSSKGPTAVAEAGPVKDAEPEAESKTSEKNIDTVVSGAGQAVEKSGTVQQTAEDDDDTDPGGSTPPPVLKPAAEEETVQTKSEEKAPAGRLSRWRSSKSKTGGQEKDEASEKNSEPVSGQTLVTDAGDSSSKKGDFPGVEQGKSASEPAEKQVETSKDSPGELESLKDSSKKASNISEAKPKRSQSSDSSRSKSRSPSAQRKRSVSRSRSRSSSSGSSTDTGANKTASSSSVVKRDSSPKGSSKPAATDDVMATVEEKSVSKKADTQEASGESASVTTGDDVTMDTGKPSASVDDKDIESTETASKNDAESKPSDVKEDDAVSVVVTGKETDQAQDTPEQEDKSKKEKGVKKRKWGSKTSKAAKTTKRTTSMEISSDSLKGLIGEVKLTETVFDMETEVVNTLDYEPEEDRRDIKMKRTIVQDSPEQMEVDNVEDDARTVEAREDVTTVEETAPPADTEKKIIKITSAAPKEGGKKLKEIKKGKKKKEEDETLKEDKAEGKKAISKDSKERITATTRPAKPLLPAVDEPEPVGTGSQSPARNPVDRVIRIACLVRPFTVNQLKELLRRSGELDEEYFWINDIKSHCLAAYKTEEDAVKARSCLHGTKWPQSNPKILVVDYATLEDVEHRKAEDAGVPIPPKKQEEQRKPVEKKEDDERKKAREQREKEREERDKEAREKREGDRQRRRELEKKNPVREWDRDKIQQLSRSRSRSKEDERPLRRSRSRSRDRERQKRREQSREKKDEDRRKEKKQKETKAEEEPPAKLLDDLFRKTKATPCIYWLPLTEEQALQRQVKKQEQEKERQKRRAALEEKEKEEQKKREAAREERQREREREREKEREKERARSRDRERERDRGRQERARSSESRSRSRSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCX4</accession>
    <name>A0ABM0JCX4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gephyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101848167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090817.2">
        <property type="nucleotide sequence ID" value="XM_005090760.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848167"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="13"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="441"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005090817.2"/>
        </source>
    </evidence>
    <sequence length="675" mass="72669" checksum="34C0C83E65DD8DFA" modified="2025-10-08" version="1">MAEHDSEHDLKVGILTVSDSCFNGTATDRSGENLKQVVESRKLFNGRVITKDILPDEQEQIKNKLLHWSDHLKLDLILTTGGTGFAPRDVTPEATKSVIEKEAPGMIVAMLKGSLEITPLAMLSRPVCGTRGCTLIINLPGSTKGSSECLQLVSAGIPHAVDLLRGHKPGVEKTHATLQAEGIRSVHGGHHSHSQHSHGSAHEGHRGHNVFHASGGHGPHPPQHRAHAHRTCSNSHKQHHEMHSHVDTEKVALRPRESPYPMLSVEEAVGKVMDNATVLHSEAVDIKDALGRTLARSVCAADPLPPFPASIKDGYAVRAEDGAGLRMVLGESSAGDVPDKPVSPGFCVRINTGAPVPAGADAVVQVEDTQLVEASRDGKQEIQIKILKFPTVGQDIRTVGSDIEKGQEILCEGQRLGPAELGLLATVGVTSVPCYRMPVVGVMSTGNELVDPDTPLREGSIRDSNRTTLLSQLKEYGVPSLDLGIAKDTPDALLEKLTDALNKVDIIVTTGGVSMGDKDYLKQVLQVDLKAHLHFARVFMKPGKPTTFATLEHAGQRKFFFGLPGNPVSAIVTCNLYVIPAIRKMTGCPNPHRTVIKVKVDKDLRLDPRPEYHRAALTWESGDPTPTAHTTGNQISSRLLSMNQANVLMRLPPRSDALTHIDKGTVVDALVIGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD37</accession>
    <name>A0ABM0JD37_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-like GTP-binding protein rhoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090941.2">
        <property type="nucleotide sequence ID" value="XM_005090884.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855618"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090941.2"/>
        </source>
    </evidence>
    <sequence length="205" mass="22855" checksum="9C6439A319149845" modified="2025-10-08" version="1">MKTQSEKSQESSHLLSRVCHKVAVVGDTGSGKTSLIFRFSRGRMPTLDERSLTVIEVDVMDITRNGKQFQLSIYDTSGREEYARLRGLTYNHCDVVLICLALDSPQSVHNVINEWVPEVRHLAHNMPFILVGTKSDLRVKGEGRAGDYITQKQGRSLAKRVGAAKYMECSALSEANSDQKEVKRVFGRALREATGDTSCCYCCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD41</accession>
    <name>A0ABM0JD41_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101857085</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090948.1">
        <property type="nucleotide sequence ID" value="XM_005090891.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857085"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090948.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18310" checksum="26BE1DBE1455C3B4" modified="2025-10-08" version="1">MLKFLQWLLYSSKCPLFVPGYFGSNPSSANRWRTLFWAVASCLVWLQLEVTWFNFFAVSLLPVLLAAIFMVVTNQLHVSRSDVGSLLTLAACLGFVNGLVVLTSFPLYMRYEYLAKKIVWREAHLFQRWCPNTYVTVSTVCLITLLVKGLRVSCWRAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEH8</accession>
    <name>A0ABM0JEH8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101849432</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091893.1">
        <property type="nucleotide sequence ID" value="XM_005091836.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849432"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091893.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="42908" checksum="55864FF675800E4A" modified="2025-10-08" version="1">MSLLMLKTKNLSWQDHTLNIEVMLAPLRSTLLLNKHKTLDTKYDKEKALFERQKDACIKDFVVEKRLIERRRQKLNKRKKDILAETRAKSALEKEDTTVTEAVNQERSYSAPGRDRTAHDQGASYNPCLPKLTLKHTPLFGGTPLRPRLFLETGLTSEGKHGKPRESIASTGSARYTQDGSRKSTLIDSDRKPPIPPPKNTTGDNQRGLPRRIPGVTFLDFLDQDDSDDENNNIIVEVKPKTVEEKVREFLRDMEKFNSRPATACSSAGGRTDDSLVSSRYTRMSERSGASVANRYNTFSMDKKSLEKAFDRYCEKKSHEDLLKAMKLAAKMKAHIRQARNASLVPTMAAFKSSRSFMRLLKRQQRKDKQAAQGMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG09</accession>
    <name>A0ABM0JG09_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xyloside xylosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101850701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092847.1">
        <property type="nucleotide sequence ID" value="XM_005092790.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850701"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042465">
        <property type="entry name" value="XXLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612:SF1">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005092847.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42689" checksum="5F900143C8C38D23" modified="2025-10-08" version="1">MRKCMKIQYVSLILGTIGLLALCMKLLAKQTDPFLSIKYHYQYDEDNPERRVQHWPHHNYSSVASHKDENVFHFHVMFIYSLVSKKAYVKESFDACVSTLLNHSSLPLAIHIVGDIESFGLASKTLKAASFYGPVIHHDTESFPEDVQTVISSVRGAVYQKKKSKFSDTIFFLSMVMHRFLPSSVSKLILFDVDIVFQSDVKDLFSLFDDFNEKNVMGLARENQPVYRNVFWEYRKKNPGTRIGEPPPTGLTGFNSGVVLLDLDKMRRSKVYNVYLDEVRMLSSLVQKYEFQGNLGDQDLFTLISIENEELFYVLPCRWNRQLCTWWRRDEYVEIFDLYYACEGPIHLLHGNCKTDIGLPLKGTRKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGK7</accession>
    <name>A0ABM0JGK7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-adenosylmethionine mitochondrial carrier protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093221.1">
        <property type="nucleotide sequence ID" value="XM_005093164.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857008"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="96"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="187"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093221.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30447" checksum="6E01707FE4D4EC4B" modified="2025-10-08" version="1">MEDVIDPDIVENTDFRVALAAGGAAGTSVDIILFPLDTIKTRLQSERGFWKSGGFRGIYSGLFSAAVGSAPTAALFFVAYESTKTTFNNITQDRRYQSFGHMMAASIGEVSACLIRVPVEVVKQRTQALGTGSSIASFKKTLNSEGLGGFYRGYFSTVLREVPFSIIQFPLWEYLKSRVSKHTEQPITALQSSLCGATSGAISAAITTPLDVVKTRVMLAEKGSSIAKGSISFVVQTIIKEKGFMGLYAGIAPRVMWISIGGSVFLGVYEKVKITLTQMFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHE7</accession>
    <name>A0ABM0JHE7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101849443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093720.1">
        <property type="nucleotide sequence ID" value="XM_005093663.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849443"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="596"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005093720.1"/>
        </source>
    </evidence>
    <sequence length="775" mass="87848" checksum="7882FE66028968A5" modified="2025-10-08" version="1">MKNISKYILVYRQQAAQPRLLMTDVSSQSCLLSVVRHFASLRFASLLAISHGGLQNKSSNASVISCRNLSYESNSTTSDLLEEDNSRKRKEECQVQNDKCTARSENVFPNNYCMSTEKVNASETPSAEGAFEALNRGKESLLLHKKHGPIIASLLQKTYHNLVRNEHLHYNVSQASQDGEDQANQLSANEKREIHGNDVIHISQSSHADSRRDKPPVCSFPIDESAQEHSLLLSRYRQKFHQKMFLKYQRPSSREAGLLTKEYGEAEDLVRETVSPFIAAGVISSCSPCVTSHLKGFYWKASLSLYWPVKIGCTGMHPVKEEAVRRAYLLLCVELKKVGLICRGNDGRWTPLKCDQVVSMLDQLARYGEITVGSSRGRGSKIVLEQLKGRREGDIFTINHKAVPAEQRKRLKRCQQMENDTKKVLTEDCFETYKGQGYNTSHDMKKESEKLFSGNDRDNSLQKSVTLKNLMDDTNRLLDFEPSTLEIDSSMSSGPLVDEVGRSMDKERLSKDLKWKCTVHVGWPLPFSVYSYGVSLPSAQMVGYMAVATKLKLYDLLTKCNNQVCGLTLEHHIVNETLKQWGSQSLLWNSDDVAEFEADAEIFCDASNDGFGAYLLQKDTQKVSWISECWKNQPNVLHKLCTKNGQYLHSTQAELFALVTAVFSWKKKLRHKKVLIFSDNMTSVCMVNTYGNTSVTSDMCVDSNDYLIQVLQFTRSVYFLQLKAVWLQRDRNQLADHLSRQDLQFFRRALPNAALNKTKAKKLKIHGNSFWADGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJG2</accession>
    <name>A0ABM0JJG2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-crystallin SL11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095055.2">
        <property type="nucleotide sequence ID" value="XM_005094998.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852914"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="83"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095055.2"/>
        </source>
    </evidence>
    <sequence length="205" mass="22963" checksum="9DF049044EBF2ACE" modified="2025-10-08" version="1">MSSGKVSLQYFDLRARGEILRLVFSAAKIPFEDSRIQFADWPKLKPNTPYGTLPVIEIKGNKYSQSLALATYYARENGLYGSSNLEGLKIDMIQQLREDLLGVEGKGFGEQDAAKKAEIGNELATNVYPRYLKYFNDILKANGNGWSVGSKLSLADIVIFEGTESIQQTNRELIDQFPEVKALRAKVAKVDGIRQYVQSRKVQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKL8</accession>
    <name>A0ABM0JKL8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="7">1.5.1.5</ecNumber>
            <ecNumber evidence="6">3.5.4.9</ecNumber>
            <ecNumber evidence="5">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101854708</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="7"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EC" id="6.3.4.3" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005095912.1">
        <property type="nucleotide sequence ID" value="XM_005095855.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854708"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="19">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="20">
        <location>
            <begin position="144"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_005095912.1"/>
        </source>
    </evidence>
    <sequence length="934" mass="100739" checksum="6161029891C5E93D" modified="2025-10-08" version="1">MAQVLSGKEVSGDIKKQLATEVSEFQSKFPDFKPGLAIVQVGDRSDSNVYINQKLKSAVEVGVAAEHIKLPRSSTQYEVLATVERLNNDIKVHGIIVQLPMESDNEIDAHLVTNAILPSKDVDGLHQDNAGRLSRGDLDSCILPCTPRGCMELIKRSGVEVKGKRAVVLGRSKIVGAPMSDLLTWNHATVTVCHSRTADLKEEVSRADIVVVGIGKPQLVKGDWIKPGAVVVDCGINSLPDATRARGYRLVGDVDYASAKEVASWITPVPGGVGPMTVAMLLKNTVDQAKKSYEEMALASSWNIQYLPLPLKEPVPSDIDIAKAQVPKDISVLAQEVRLTNEEVDLYGKKKAKVSLKVLDRLKAQENGKYVVVTGITPTPLGEGKSTTTIGLAQALGAHLKKNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDLHAITAANNLLAAAIEARMFHEATQKDQALFNRLVPEKKGVREFCPIQMRRLQKLGITKTNPNDLTEEEIGKFARLDIDKETITWQRVMDTNDRFLRKITVGQGPQEKGHTRETQFDITVASEIMAILALTTDLGDMRERLGRMVVASSKAGQPVTADDLGVGGALTVLMKDTIRPNLMQTLEGTPVFVHAGPFANIAHGNSSILADKIALKLVGKDGCVVTEAGFGADIGMEKFFNIKCFYSGLVPNAVVLVATVRALKMHGGGPTVVAGVPLPKEYTEENLGLVEQGCSNLIKQIQNANKFGVPVVVAVNGFATDTQAELELVQRLSRENGAFDAVICNHWAKGGQGAMDLAAAVDKAAGQTSNFKFLYNVKDSIESKIETIAKEIYGADGIELEPLARAQIERYERQGFSELPICMAKTHLSLSHKPELKGAPTGFVLPIREARASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDIDPDTEEILGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLL8</accession>
    <name>A0ABM0JLL8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101848286</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005096574.1">
        <property type="nucleotide sequence ID" value="XM_005096517.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848286"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="13">
        <location>
            <begin position="70"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="12">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005096574.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48609" checksum="714F7DCF0F81A336" modified="2025-10-08" version="1">MNQYLRTHWVACKMYTRDRAVHKLIQTFIFLTILFDATGETAGDSSGNSSPSEPFPGSESGTHRSPILSERMDSGERIKLWPNATVYYKVKPNLHTPTDLRLIQTALDHISSYTCLKFIKSRFEILHDRLIFTNGDVCFSKLGYQGGRQKIILEKACRSYGPGHIIHEVLHAVGLPHEHQRLDQADHMRINYDKIEPFLHNQYKPYGSGVNTYGVDYDCNSIMHYGGDAITSLDPSCQKKIGQRWGMSFKDIKLVNLMYQCPHTGGCEPKDCGQDGIQLPRANGKPSCECWCDSGNVKVPLVLCSNRTPAIRAEVTAPPSTPEQECSDGWRYCERLKEEGNCFSNPKLMNSMCRRTCGWCPKNSYKDSKEGCFNTEDSTNPPTVLTSKQMAGRNDDDDDPWEFSRNRASSVIVTSGPLAVLCLLVTFLLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLU9</accession>
    <name>A0ABM0JLU9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101861358</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096715.1">
        <property type="nucleotide sequence ID" value="XM_005096658.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861358"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040091">
        <property type="entry name" value="LRRC56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005096715.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="79853" checksum="60C2CCB54131EC60" modified="2025-10-08" version="1">MALVIDRPPLRGYSSYQSNTFTMDDEAKIGEKTQDEKHDSSSGGFPGSEARPMSALARGVQITEFAESRVNPTPLLLEESDILLEQYLSPGKLQLLTGVDNLELVESLELKVDSRETSLGNFGGLLPNLTELKLSGSSIACARDLGSSLRKLRVLWLTRCGLEELDGISSMLNLKELYLEYNEVTDISPISMLEHLEILDLEGNNVDDITQVQYLSLCPRLRRLALDGNPICVCPSPTHDEPGYDYRQTIKKLLPNLLVLDDERLDEASSSLIKHNVFDEDWAYLEELQKDAFLQQEFSENQEVSNEAQAIGERPPSAALRPATSYRPGSALRPSSGFRPLSASRRPQTMSGPSTPTRPGTSASVRPVSSDAVEGIESSSELTIGGVICGNPSKALRQRRKGGAGSKEEIQKGLSKLMQKGAIFNHSENAEDVPLKAEDEMNSIIEELQSWKVEHEKRMQDILKTKEAQVLVVDHDEAVEVSDSEEDSDFDLPRETIDYRPGSSQQRHSADLRLKSSKKKMDSVGYPSGSAESSLRAQGVSSRLSASKIRDGDSEYRQRFHSDDYDEDESNPAAEVFHDQGSSLASFSGYARSRSREGSMGDSWSEGEGMTPERPRSRGQGEGGLAPLRAPSPTSAQIINSLRARQTERPPSPRSKRLRVGPTGLPVSSQTPVIRNSIVPPPSRSGLVSTTAMSSVSRGNVPLLPSQPRIARQLPETPKLLPHPPKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMT5</accession>
    <name>A0ABM0JMT5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Progestin and adipoQ receptor family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101856963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097368.2">
        <property type="nucleotide sequence ID" value="XM_005097311.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937376.1">
        <property type="nucleotide sequence ID" value="XM_013081922.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856963"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF15">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005097368.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012937376.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38460" checksum="6906FB4F5C6CDE42" modified="2025-10-08" version="1">MSLPFTERYSSIKNRLGATYSSAKQFEADSYHILDIEIDENGVETCQTGLCELNNSQIALLKYHEIPDFLKGNPYVVHGYRSMLPFSLCMKSLLFWSNETLNIWSHLGGFFIFLLLLLWDNLITLPRLGGSFSDHLIMTIGLVCFMFCMLCSTGFHIFCCHSERASRRWLAVDMTGVSIGIIGCYLPAVHYAFYCLSIWRDVYMFVITILSACTLGFQLHPRFFTHAWFYPRMAVYVGLVAYGIIPTVHWIVLNGGMSSVLVKLFIPKVTMMYLLGGLAFSFYITQFPERMFPGRFDFVGSSHQLWHLLIVVAFCYWHKAGQEILVYRIAHECHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN74</accession>
    <name>A0ABM0JN74_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC118477115</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC118477115</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097642.1">
        <property type="nucleotide sequence ID" value="XM_005097585.3"/>
    </dbReference>
    <dbReference type="GeneID" id="118477115"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045785930" evidence="12">
        <location>
            <begin position="21"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="765"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005097642.1"/>
        </source>
    </evidence>
    <sequence length="906" mass="103873" checksum="935A1FB945C404F7" modified="2025-10-08" version="1">MSSTLRTFPLILVAFTCSQSLEFEHAPRTDESPCDVTDDDVRGGEYVNCTARGLTSLEPNWFPENATTLSLDHNMLQNLVSGCFRHLSELQVLTISDSQVTTIHDDALRGLGKLKELNLENNNIYTRRLSRTLFSHVPNLENLYLKGNTWENEGTRESPSSSAVPFSNLSLLTRLSIDGDSEIYFGQPFFKLKNLTYLYVYCPHDVIKGSNRSFEGFRDVALRELVLESPTQEAYFETGIFANVQNLDILRIHDVAIGNQNIMKCLWPFENKGMVLIDLYRVNLRHHRASPKATCNDGLMTKESLKHLSNICLSQLIWDASKVVGIEPRALSVKPNLRKCLKSLRFTRNLIGKMDQWRSLILELIGFESLEELQWGALDWCGPGYDFKFRNVQNVRKSVKETNYIFDTKHTSVTLTHALPHYSNRNNGNSREILTIPSGNRSLLGTPSIRFPRERERTRFTRSSFFRCPKHLQSLIVVGLDGYLRIPACHIRDGHNVKEIRIVSCDFIEWSGHVTGLENVTLMDFTRSHVISHPNFVPFQNFPNLETLLLNAMSGSDFIDQLLKESWLEKTPKLQHIDLRDNHLHKLPSSVFSSNLRMNSILLSSNRLTSLGFDLSTTPSLGVLDLRKNAISSLDIASRTALDTHAQSKPDFSLLLEGNPIYCMCSRVPFLVWLHTTWVRLDMSGNYSCIDDRGQDRWTSDLITTKALWRRCVGKTFLLVSLSQALSLIVGFLAVYMWRRFRTAVWAFFLNILAPGFRKTKMEDCGIHVFVGYADDDFRFVRFVLRRYLEEDLSLTTYIHQRDLRAGYLDQQLLDAIQDSWRLVLVLSANFLRRYEKAHLVMKMCTSAVTPVNPDRVLVLVEQGQGRHVPDYVLAVLDEEKLVRLHSLNEELGYEQKQRIKHLILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPV5</accession>
    <name>A0ABM0JPV5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101854574</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098736.1">
        <property type="nucleotide sequence ID" value="XM_005098679.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854574"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="559"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098736.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="75372" checksum="1957A2C5C9377A52" modified="2025-10-08" version="1">MSKGGEINKSSDRGRKGKYKGHTPEGDEPDHRSGSRTDDNQRHGSPERQQRTFSKGDRSSKSPDNNTRRPQNNPKNKSGNESKENSRNKALESGGSNKGSTVSNRSNSQKPKNPDNKAALETIICLRNKLKSFKKKHMGASARYKYPSCAQCLEEDILRMWRMSSEKLHEADDFLNITLQKPVYEDIMDSDDYMDLITIAQREQEFRTLVPEVRRRLSNCLNQHVYKSCKSLKEESGDYVVVSAQEYESNISKYISEIEAKSNEIEDGHSSYQQMRTPFLEFVRRGEEHSGCMNKLSNSLLEACKIVETWVREDDEYPDKLTQEMESTRKLKENVNEEVEAIKSKMAVNTSDMLRLQKGQSRAGRSYSQHKRDRDMLRLRHGELSYKKSVVQGKLAAKQDERDRLKEERQQKEGMSPRESGNFLTKLENVERDMERLENERKTTERQMRRVEKELKPTGDKTYEQKPVESPDQVDYVECRNKRQELEKENKRLAKQLETTQARMADIGRQMETLRRMREMKLSPEAYRKGVRQRLRKENLKSNGLQTLTDACKLAAPSIGKDWKKLYLHLPFDPPRDAAKRQHDVDTLDYLCSRRDVTADEQALQSLTKWLSFHRRGNVVELIQTLKDMRKRNVAERLHDKFVIHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ08</accession>
    <name>A0ABM0JQ08_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dye-decolorizing peroxidase YfeX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005098845.1">
        <property type="nucleotide sequence ID" value="XM_005098788.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859857"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF0">
        <property type="entry name" value="DYP-TYPE PEROXIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="6">
        <location>
            <begin position="224"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005098845.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="42072" checksum="0EE1F025C9596222" modified="2025-10-08" version="1">MASFRTLSAVRSSVIAKGLVRPLSTRASTSSRSKGALLLGTATAGLIGYGAYRKWDVFTAKDDAAKAVMSVVNSSAVTAAGPPQAQPSVFSPGKNHALYLWIHLKPEANSKEVARACAKLQKLVDAVVDPAMKDEDDEILAGVGFGPNFYAQVTGRKAPKNFTYPYRKGALGDMPSSGGEIFIHAKSNETSKLFELCQLFIRSLPKDSVDKFEDIYSFVYQNGRDLSGFIDGTENRADDEGRQEVAVEKETGGSYVITQKWIHNLDVISTEKTKTLESWVGRDKSDSTELSRKSISSHVARMTSGNGFQSPKPVEIVRQSMPFGTISGEAGLFFIGYAANPINFEYMLDRMVGSGGDGHSDDIMRLSKNVKGNYWYFPGAQDLAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ65</accession>
    <name>A0ABM0JQ65_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-phase kinase-associated protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101864225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098954.1">
        <property type="nucleotide sequence ID" value="XM_005098897.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864225"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="146"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098954.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="56096" checksum="8C9E30B8CADF0BE2" modified="2025-10-08" version="1">MAKRRSESEFPKHEDTGEENQNRPPITRSVSEKRLKRHCGETAADSETVQDPDAPSGEEIADKERFVTPAIVSHDTDSPNCPGESSESSDQAPRILVLNQGANVENPPNASLSGRELLAPDAFLRTPPTVKSKVYLKLGEETYRGFNVFDKLSDEIILEVFHRLPRHMMCTCALVCRRWTRLVCDFSLWRRLDLRKKCIKPGVLKIVLERGVQILRASQCEVMGSFSSTVHGNPDPRSSPLSEDRMYRVQMLDLSMANVETNLVENLLRFCPRLNRISLEHIPISEALLMNLGQNSPHLQSLNLAMCTGTTGDGLKAIFTGCPWLKSLNISWTTMEGDDVRKVAKALPRQMLQLNISGYREKMTDEVVEDILERCPNLKILDLSDSTEVTDASVLKIPKALPHLQTICLSRCYRVNTQTILSLHHAPCLQSINVFGLMRDPSLAVLEEHMSKYRINKDPFSSVARPTPFNSRRHLIWGVSPSPRGLPVDPDSDLFFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS52</accession>
    <name>A0ABM0JS52_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101860417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100283.1">
        <property type="nucleotide sequence ID" value="XM_005100226.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860417"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005100283.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20391" checksum="667BECD9CBD9E81F" modified="2025-10-08" version="1">MPAYHSQFLNPPRLIGNMALLPIRSQYKGPAPKDTSNYDIIDEAIYFFKANIFFRNYEIKSEADRTLIYITLYISECLKKLQRCSSRAQGDKEMYTLGISNFPIPGESGFPLNAMYTKPGNRGDEDTMRQYLQQLRQETGVRLLDKVFDQGDKPSKWWLCFAKRKFMDKSLSAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSR3</accession>
    <name>A0ABM0JSR3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101862421</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100639.1">
        <property type="nucleotide sequence ID" value="XM_005100582.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862421"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039253">
        <property type="entry name" value="APLF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315:SF3">
        <property type="entry name" value="PARP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="412"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100639.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56428" checksum="CF47EA7C87046C0B" modified="2025-10-08" version="1">MADGPSPAKKAKTDSSDLPECPYGARCYRKNPQHFKEFSHSKDKDEPASTSGAKPNIDDSSLPPCKYGDKCYRKNLLHYAEFSHPTSHPIKAASGSGDDTDVYDSEEEKDEKKGSESKDIISKDLSLVKRFSQLTPEERKELIKRAFEEKQKLQQELDGAKKMVEKKDKELNHMQKQLNSGLLLMEGEEEAMKKNTTTYFELVAERSYKEGSASQFHFRLAESQFYRLLSGPASAMTRIVRVEYVVTPHVVKKFRQAQAELKKKRGEQFSYPVLGFHGTLEKNIQPICENGFRAPGEQKFKQRTDNGWYGAGVYFSEYPSYSMGYVHGASKLMLCQVLPGKIYKCKKIIAGASLQEGFDSHTSPCGKELVIFDSASIWPCYVIYFTKAAHGDFQYASPSGKVYGYKDVVNCPRSKVFSGMMITFSGKMDVSQDLLLDLIVKHGGDAGTAAYFSILVSTEQEVASKKKKCATAESKKIPIVPLAYIYNCIMAGKQLSFEDMRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSS3</accession>
    <name>A0ABM0JSS3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-associated and SH3 domain-containing protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101847825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100662.1">
        <property type="nucleotide sequence ID" value="XM_005100605.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847825"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005100662.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31423" checksum="2F675C69BBF2C230" modified="2025-10-08" version="1">MAEKHRSPQKESETKTENGDIGRRLFVMRHGERCDFAFGRSWVNRCFDDKGNYTQSDLNLPPAMVPRASHKQFLKDSPLTEIGRFQARSTGDALQRAGVDIQHIYVSPSLRCVQTAQHVIEGMGNNATMCIEPTAFEWFGWYKNAMPNWLSPKHLADCGFNINVQHKPFVSVDDLHLDETVTDYYERCHKLAQKVLKKHEAEGGDILIVAHAGSLDTFTRRLLGKSPRNSQEMHQILSSFTYCSFCCCVENSKTGKWALGQPPIPPLHEFNWKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTI9</accession>
    <name>A0ABM0JTI9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Krueppel-like factor 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101124.1">
        <property type="nucleotide sequence ID" value="XM_005101067.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857885"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF174">
        <property type="entry name" value="CABUT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005101124.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35160" checksum="8BF0F363953FFDD7" modified="2025-10-08" version="1">MALRENNKLTYDLDTAMAAHCLLAMSNRQNDHTYVLTCDPPGVGENFDCRPNGDELACKQEVKSESEGENKEQDCKYSPAPSTDYSPSPGENLSETLVARILTDLKSFKQDNDYHEEFSITVRSMGRDNTVNEYEIKSTPKSRQTTPTLNQTRSAMEGASGRASSSIHGKKTHSCPYPACGKSYNKSSHLKSHIRTHTGERPFECDWLGCGKRFARSDELTRHKRTHTGEKTFQCPLCDKRFMRSDHKIKHAKRHALFHPSMLETNTRHVARSVIPPPQQQQPCDFQYVPDCDMGSDGAASFRSNNTSPAAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTZ1</accession>
    <name>A0ABM0JTZ1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101430.2">
        <property type="nucleotide sequence ID" value="XM_005101373.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848827"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="5">
        <location>
            <begin position="291"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101430.2"/>
        </source>
    </evidence>
    <sequence length="732" mass="78114" checksum="23E6ECD3F173E2F2" modified="2025-10-08" version="1">MGALWTRFRGKQTTYEILEGIDKDINRLQKNRKDNQERLKRFVTRLIIYSVVLYVIAAVVFFFLYLPDTWQLRFLYSSPLLVFPFIIWGLKKLLHWYFVKRIAKNDVALRELREKKKQILEDVMETETYKKAKEILEKFDPARFKKMEVESSPSSPPGQGTPGTSIQQRTASRSAQQQPVIRTPAGAPPTPVHTPSQRMVRPPQPMSKQPLRQPTPTSTPLRPMGGYGATPGIRTPAPIGRGTPQQQQQHQRMPMSTPQGGGRGMVMPAGYVPPPGPPMPRTVLPRDRGTMDRLMDYLVGDGPENRYALVCQQCYSHNGMALKEEFEYLSFRCCYCFFLNPARKQRPFAPRMEFFNPLARGQGGQGPKQLPPNNDESDEEDTDDEDEENSEEEEEQKSAGPSSEKPSDRSKVGGQGAAGNGVPSSSVRRGPGPAATTSTDQRSQGTSSKPAAGSSGQSTLRSGIPKVAAAAATMSKGQGQTGEQLLPVGAVKTLRPAATSVVASKNAGAVVSSGAVKSPTSSESRFPQSQTAAQARNTFASPPVSASVDNKAASESASAGSVVSQTGLRSSSQPQKKGLGDSTSATATPVVSSASLRSQIPSLVGTKKPVESESTDNSTAVTAQEVLSAPAAPPVQRDADDIISNADANGAHTENGLNNSDPSVPLGETAPEEVSSSASLVTALEYDGGSGRDNIVDPPSGDAAEGDVHDGRNPPPNEASAEGTADGSSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWK4</accession>
    <name>A0ABM0JWK4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101863915</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103216.2">
        <property type="nucleotide sequence ID" value="XM_005103159.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863915"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047039726" evidence="2">
        <location>
            <begin position="24"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005103216.2"/>
        </source>
    </evidence>
    <sequence length="382" mass="41350" checksum="5224E1E7533E4DAD" modified="2025-10-08" version="1">MGVSVRCCCFLLLSLLLLQHSYSVNVSQICRHRCLYGRGGILCNCNAMHFAGKRNNKATSMYAPPLRPTVAARLAATPDIAAQVGAEEEKIATSRRLRFEGLEDELDEIPSFFASSRGNEDGSASGVVPGKNVGAAANRGSSVGLSRDSDAVSTGSLSGDRHRGARPAFLYPDSAAGENRRQTSEADETAEDDGLVGLWDRNLIDNFIAELEQNVAAAAELTNGFSDNTNGNDNDNNNIASANNEYDGRRRMVGGSNAVLEGSLPYLLFSKQRDRLADRLADRQRGQREGEEMYDPMLRSADLLLSASRAGPSSVAQHQARRLSNNNDHRGDVTGSGRDRSTDHMTKLQRIFHQAVHKSLPQVMFRKPAVGQASRQTGLVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY65</accession>
    <name>A0ABM0JY65_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">5-hydroxytryptamine receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005104325.3">
        <property type="nucleotide sequence ID" value="XM_005104268.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845119"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005104325.3"/>
        </source>
    </evidence>
    <sequence length="193" mass="21241" checksum="C48777DABC39B7FE" modified="2025-10-08" version="1">MIVPALIHNILIVHQAECSDVDDKANLVCFHHSTSQSPHYEPTTQQTTITPGLLKARKNQARLVMDGDEYETMTSANLSSTLPPSSSTEVDDVTANVTSRPVYAMSDEDREKIIIIAVIMGFTLIGNMTLILALLVKRSLRVKRVNILLINLAFGDLAVALFVNSVEILFIAFGDWALGPVMCKISVYVQVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYE0</accession>
    <name>A0ABM0JYE0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Angiopoietin-related protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104470.1">
        <property type="nucleotide sequence ID" value="XM_005104413.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859500"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045507079" evidence="1">
        <location>
            <begin position="23"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="331"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104470.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="61323" checksum="1465B6C5F5812BB8" modified="2025-10-08" version="1">MGLGMTSVYLLLAAAGLMSSRAVLLNVTTDEVVVGKTTNVSLECTDNYHQHDVVEVVMIRMLKKSVTGWTSVAELRDDDTEVTQTLQGVKAEANKSSLYNSFLRLTWPVATKDTIGEYRCDVISLTSQESFNWQKSLPATIYKKNDVTLNTLSEIVEGNRMESIRRLRAQRQSIMEDVARAVEGQREGILSNLSAALEDMGDSFESQLQALSDTFDRNKRQFPHQLLSHKRQVMARVETALEQNNREFLRRTEGLLQNVTEIVERGNSELQRQRDSILEDARKTVAEANRECLQQRDDILQNVTAMVQALEASVESRLNATEVQEKVRPSEVPVKLLRTCADVQSTNPRPVVTLDNDMTVVCDTETDHGGWIVFQRRTSGDVDFYRGWAEYKDGFGDLYGNFWLGLEKIHQLTNKGNYELRIDFSFDGTDYHAQYNSFSIMGESDNYKLRVSGFTGNLEDNMDYHNGREFSTKDRDNDEYSGSCAKSYHGAWWYNTCHRVNLNGDWGSTKSSEGLNWKSVTTYTKSATFSEMKMRPLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYJ5</accession>
    <name>A0ABM0JYJ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable glutathione S-transferase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104553.2">
        <property type="nucleotide sequence ID" value="XM_005104496.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857270"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="112"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104553.2"/>
        </source>
    </evidence>
    <sequence length="234" mass="26975" checksum="B4F8254961220D7F" modified="2025-10-08" version="1">MWARLRVYIHPRRRVNYHSFSVARQLKCTYRMPTYKLTYFDSRGSAEFIRLVFAAAGQPFEDVRLTREEWADFKPKAQFGSLPALEVDGRQFGESVAIANYVARELGFFGKTARDELIINQTVQLMQELKSNAIPIFMEQNEVNKAELGKKFLEETVPRYMDYAKRILEENTTGYYVGSSLTLADLAVYDVAFNLEFRHPGILDKYPVIKAHSETVLTNPKVKAYVDARKPTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYM0</accession>
    <name>A0ABM0JYM0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chondroitin sulfate proteoglycan 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101850497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104611.1">
        <property type="nucleotide sequence ID" value="XM_005104554.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850497"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF12">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 4-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045627558" evidence="8">
        <location>
            <begin position="31"/>
            <end position="2440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2265"/>
            <end position="2289"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="37"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="219"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="693"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="937"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1170"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1282"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1393"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1509"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1868"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1978"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="2083"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2208"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2297"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2355"/>
            <end position="2411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2227"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2355"/>
            <end position="2371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2399"/>
            <end position="2410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005104611.1"/>
        </source>
    </evidence>
    <sequence length="2440" mass="272310" checksum="25E7D337706D969F" modified="2025-10-08" version="1">MTTMTNRLNPVLFGVCQIVVVFHLLQGALGSRSDANEASFYGESYVFTPVREASSSNSVSLQFRSHRPQGLLLLAAGQTDYVVVQLNAGIVETRVNLGSGEAVTFSARGVRLDDSRWHEVLVNRTLDTVYLAVDGIDAGQATTPGTYHDLNIDLGVLLGGTGNLKEEFYRGAKSFRGCLRSVFFNGHDILKEAKELKSAQNAFQVAWHCDDEFTASSNSPISLSSDTSFVAFPHLRIYPQSDGGVFSCEVKTRSPDAVILFNSGQGAAWEDFIAVELVDGRPKLSIDKGSGVIEVWLDYPVSDGKWHKLEVSVSETVAELQIDTEKNLTRFHLGGQNYLNLAGHVYLGGVGFKTRSHAIRLGLVSLLGKSAMKGSMVGCLRNIMMNSRTFGFHQIEVSRLIDPDCAWEFPCSQDPCLPGAQCTELEGTDFRCDCGEQVCVKDTFRSDFDDWNEDTRGIVSVSELKVVKGGVVVINQEVIQLNRALFSNGLTEEHVVFTVKDRPKSGSIEIKNSRGSHSANTFTLRELTSNSIVYRHYGGEEEIDSFTIELTFNSLLHRQEAKLKDKYEFVVPVRVQAPKSSNLEVVLSYGNIISVTPGAKIRITPAILNVPSSDIDSSKLRFVINYLRQARSMFERSDEPKISVTSFTLKDVQDGYIWFQHNGDRIVYTKVNVTDGVSVSESADFRFKEEELQVSIANNTGITLSYGSHRLITNFNLSAVTNAPLEDIELRYHITKPPAYGTLQRMEHQSSKWVDVETFSQRHLNSGRIRYLHLPSSKISNYDNFKFEVSAQDVKKESLGFQIQFKTVVLSVEHSSNLVLSKTSFGKFSNTSLSVISNAENLDFQKIVYMMLRPPQKGDLYLIPQDVTNPVIFSQVSPLKTDDNFTQQDVNNGHVYYKFNKPGFEKVNDFADLQAAYYGFIIMVRPRILYTPESSTSVQMVNNGLLGVPEGGSALITERDLSVKMDKFKRFTLSIINYPSHGHIEIVNPDTGKIERGNASFFTMSEISAKKVLYKHDDSENQSDFFTFSSSIVFDDSQSSLPDEIQEFSGTFHIAMKMINDNAPVRSVSKIFKVASGQSKVLSIKDLAFTDPDIDFDDSLLSYHRQPIPNGDIINAGTKVSVYNFTQSDLIKGNLIFQHKGNSYTRTPISVSDGQFITTSIFEIQASSPYVMAGNNTGVTVLQGKLALITPYNLSIETNMDFDEQDATFQLVQEPEHGQLRVSGRQVLRFSYRDVLRGLVRYWHDGTMEMDDKFTFTVSINSFKSPVTTFKITVEVEGVNEPPQIVHNGLLRVLAYQTKAISKDILQVSHKGYEPWEIEYIITRLPQYGHLIIGGKTVKQGEAPEFNQADINAGRVQYASESPSQLSDTMVFDVGTDVQSLRHIEFLIEIVPLTLPQNKANATVMEGGSIVLLMKTLALKGRLAQNREVRFTVERAPVHGRVVLRSGSRDTHVSKFSYSDISRGRVHYVHDGSESLSDEMAIKTEVPDASTVSQVTTLYLKVTSVDDQPPRIVVNTGLDVWTGSITLLTNEHLQASDSDSTSSQVEFRVTAPTNGHLAFLNNTFKHILRFTQRDIDSGQLVFVHKGNENGEFQFQATDGRNKDDYKIFRIRARPVQLSVMVNETVKAFPRTLELISNRTLLVKTSAENFSQPIVFTVVEPRPRKGRLVTVVGAQTLDINSFTQEEVNEGKVFFLPTSHPKDWSDGEGIYFEISTTYAQPLKKKMLQISISFSNLHQGNYRRVLKVIEPVVAEGEQVTISADLFNSSKMLESLNAYKEDIRVEFSFVASVHNGYLWFRDMTAEMGDTFTQEDLNKGSLVYKHDHSDTVYDWFQFGVMMLVPRSVSEATASMYQVFNFTVDIEPLNDAPFELLTRHPKIIVKQGSEVTLNSFNLSTVDLDTGPEGIVYIILTQPDNGMFVKKSQPLVRLTAFTQKDIDDGDIIFKHDGTRKASSSMYFKVWDTVFDPWFANMDIFVTALEIEVASDRMVPLIQGSRSVTLSSPHLKVTTNGDPDTLVYKVIQAPQFGKLRKSGVQVTDFTQLDLESGALVYTQNTDSPGEDFFVCNIALLNQDCHKDAVQFDIIMKPLVRQGPLLSSPGSHVAITRASLDASELAQITNDNPRFEISSPPEHGKIMKKNRMRKRSVDSQENFTPVSEFTFEDVLYTRVYYVASQGGAKQDSFKYKLTAAGVPPAEGELVIQLEPLDDKDQMETDISGQGEETPISPEHDSDDTGVSERGDDDEEKDSAGQGKVSGASVGSDDGNTNVIIIATVVSLLTILVVVVVLVILFLRRRKQKRSGSMEEEKQYKPRPYISGPLQLDQPHVLIEPKHDDTSLTPMSAEDAALVEPFEENTYMNTSLVSPQYSDRPTTSLGYRPGTPPGSPDVTQSDQASEDMERRSTMTSGRDSNASTDLMDWTLMDPDLLQHCRTTTPVLRSNQYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYM2</accession>
    <name>A0ABM0JYM2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box/LRR-repeat protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104613.1">
        <property type="nucleotide sequence ID" value="XM_005104556.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850975"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22117">
        <property type="entry name" value="F-box_FBXL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="291"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104613.1"/>
        </source>
    </evidence>
    <sequence length="640" mass="73141" checksum="C1E4C6B356D9BDB8" modified="2025-10-08" version="1">MARNVEEYDAFLTDIMTSVQHYRDLDKKQKEEPSEADFLIRLEGQEVVDFSSQYGSESSISYVASNLAGKTFVFPSYGDYTQTCVFRTYGKWWKVAPSGRRKYLRTSSDFYGEDFIEVSFAEMLYPVRIEVYETYNPGAIIRILACDRAKGSDVDKGIRWVTLWSSKPKACKQRPRIFAPRLKKMNFATNLIRLELNHQYMDYYTELDGIKLVGTKTPPAPDLLRNHQVLPADIGDVEDSKDGDQVFDGPSSSARYSEERYGKTYNATADGIDELALSVDALSFSADSEEKSFFTQLPKELIHFILKYLDITDLCRLAQTCSLLRDHCYDPLLYIDLNLQPYWNLVSNASLDALSQRCERLQRLNLSWLGKGGLIYSDHLAYFLHDCQDLQTLELTACKIMDSNTLALIVSNCRNLQELNLSSCVNIEDFSTFNVLSLPKLRMLNLYRTKIDTPSLLALIRSSPDLEHLNLSSCMLLNPYINLVLMDLGDCCKKLKSLDLWRMRSVNSEGLAHLYNNCPLLEELDVGWCTDLKAYTQCFVQLAEKCVKLKKIFMTANRTVQDSDLKSLALHCPNLEQIDVLGTREVTRNGVLFVLEKCKNLIFLDLSFCLGIATEDVWAWRSLFPNVAIKKSFQHISIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K076</accession>
    <name>A0ABM0K076_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105678.3">
        <property type="nucleotide sequence ID" value="XM_005105621.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856982"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="3">
        <location>
            <begin position="248"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105678.3"/>
        </source>
    </evidence>
    <sequence length="387" mass="44456" checksum="39A4BF933DFF7BEB" modified="2025-10-08" version="1">MLATYLTFCGIGIHNAQIFDAYSKEYERNRVLLEVVHDLFTEQTSVDNVVVKIMQRAQSLLKCERCSLMLRDKDGASENSFDKVFDLACPVKNGHSGGRRRPLSRGDTLTLNGQHPVSVKLSSEKDNHMKVTSKIAELVLLTGETINITDASRDPRLEHETENVKGIHTRSVLCKPVRNRHFQIIGVAQVVNRIDGLPFDDHDDQLFEAFAIFCGLGINNCQLYEQVSLAAARQAVALEVLSYHAAVPHEDVAWLKQQDIPEEVELKLQELTFNDFSLDRDQMMTATMRMFNDLGLIRKFRIDNETLCRWILTVRKNYRNIAYHNWRHAFNVCQVMFAILQACMDREKQDEIAKLQLSWIDGICLPLYKPLEDRRFTILKSGVWESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0T8</accession>
    <name>A0ABM0K0T8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type mannose receptor 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106095.1">
        <property type="nucleotide sequence ID" value="XM_005106038.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855362"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045625361" evidence="1">
        <location>
            <begin position="26"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="38"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="179"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="325"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="460"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106095.1"/>
        </source>
    </evidence>
    <sequence length="599" mass="68011" checksum="7554FA3913579AA6" modified="2025-10-08" version="1">MGKITMSLLPFLALAVVLCSDSVAADTPFQCRSGWVSAMGSCYLFNNDTRVIFDRAVAFCDGQNFGSKLLTIQSDQEKQWINTQISKYPDVEMWWTSYKGVDFDGNILIAKDEPNGLTNLTIVTEPDDTDHTQNCVELAELGLFRDEDCSSLRRPICEVEKKSSTSACPSVARFLPVPFGTSCYYYSYSYSTKLTWQDAQAKCQDFSIGTNKGHLLSIGGRDELDFVQKTLMPRLKYLSGQHWTGLNDKMTEGHYVYEDGTQVSSYLIPWMSSRNLASNTDTCFKLNQGSKVYPTSCNVYEYGLICKEKAVPMPETQCPNYWLRAADSCYYPSYDQKNWQDASKFCSDQGAHLLKIDSDDELRWLDTVNMWSRPNFYSGYWTGLNNIQTKQKYVWQDKSEPSKGYVAWARTYSATGNYRCTAFYPGRDYTRFVSCDGRYSSGCQYVKPSGGKCLTGWTEKFNKCYKVVKDTSTFVSSLISCYQDIKRQNSNSQIAVDRLTVENAAVLTFIKGLATNANVYSLYLGLNDLNVYGEFRWGWSNTPVNMTLLNFDTEPDHQDTQNCVSIFQGGFSITDRCDRKKNYICEKEKKWIPGAASTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K107</accession>
    <name>A0ABM0K107_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101848992</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005106235.1">
        <property type="nucleotide sequence ID" value="XM_005106178.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848992"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="96"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005106235.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="64928" checksum="8D0C71917BD63138" modified="2025-10-08" version="1">MENESLTSNSSAPKAKVSKDILVEPTNGFITPPPPVQHSSKDLSSYQYNVNDELRNNRPLKKVVPPHVCGQKKEGNETESEGIVKTPRMTSTLDDFEVLSTIGTGSYGTCKKIKRKKDGKVMVWKEMEYGSMSESEKQMLVSEVNLLRELRHQHIVRYFDRIIDRTRSIIYIIMEYCQGGDLSSIIARNRKEGSFIPEEFAWKILIQTTWALKECHRRKNGKAVLHRDLKPANVFLDAESNVKLGDFGLARVLHHESSFAQTYVGTPYYMSPELVNNLSYNEKSDVWSLGCMLYELCALVPPFTASNQSELNRKIRVGEFSRLPIQYSLELDLIIRKMIQVEVVRRPSIDSILADPIVQCKQETLERRMSAVPLCGDLASDQSGGSDQDLANKQEELQAKMRQLELKEKELESREKSVALREKLAEEKMKKALELLDQYRRGDTSSTTATPVATPRSIIPWSPSQEDCSFGSPHSCLSKGRDPESPKKHVTFHDYLNGKENLRQRSSPYSGLTLNAYTGLYTGREETYTRDLLRRDEVRDRLFSAKDRTSLGSRDIDSRFTSKNLLYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1F3</accession>
    <name>A0ABM0K1F3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA annealing helicase and endonuclease ZRANB3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101850276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106506.1">
        <property type="nucleotide sequence ID" value="XM_005106449.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850276"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF3">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="73"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="389"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="886"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="593"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="938"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="997"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1103"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1055"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1122"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005106506.1"/>
        </source>
    </evidence>
    <sequence length="1551" mass="172523" checksum="5A5E1F53C6CBB88B" modified="2025-10-08" version="1">MKKAMDPSSCGPVHHNNDDNVEDQLLEPDPPPLSQPQVQEQGEKDCYADCPILKKLPTKLFKRLLPFQKRGVQFAVQKEGKFLLADEMGLGKTLQAISVALMYRSEWPVLIIVPSSLKFCWIEELEKWMPDILPKDINLVHTGTDASGIADSLITIITYGLLRHPSSTVLREAVTARKFKVIICDESHCLRNTKTLSYKTVVPLIKAAKRRILLSGTPALARPVELFPQIDAICPGKFGTFWQFTERYCDAHMVYYGKVRQRKVDGASNLEELQKRLEALLMIRREKSEVLTELPPKQRQRILFELKQSTMKTEILSTFANLKSQLCRGDKTVRKILHGQAASSEFPTQLDEEGSRRDDEGQKSDEASVSVFSEVSRLYRMSGQAKIGPVREYLEMLCENSKLKFLVFAYHHNMMDGIAQTLWDKNIKFVRIDGHTRAADRQACVSQFQTDPETRVAILSILAAGVGLTFTAAKLVVFAELYWTPGVMLQCEDRAHRIGQTSCLPVHYLVARGTMDEWVWAAVCKKTVVTSMALTGQSRRLEHAEGDNQQIEILSNASLWEPKEEQDLNISDLVQSQRDPDQSCILDFFSSPRQNSKTSAQAPKLQKPLPLQRHPLLKGDKFQKLRETGPLKSGKEQRCVGQSEADDRKSTCNTKNKKLLDVIVLSSEDEANVFKPVFKRRKKKQKSKLQKSKVKEKVALPALETRTANFQKENTAEVCAASNDEDTDSSLPDIPCIVKRKSEPTIVKQASGKEKCQGADVGAVFKSDTVIASDLGATSATSQMRGKSKHCSELGEGESRKVLVIRGCEEQTASGDDNSVIKEILNSHSTESLKSRVMTVDSHSTELSLSESIKSDSFTVAVGIELKTFSEEVQGPVAENVKDVAVCGDEWSCPACTLVNHIDRSRCEACNTSRQSIISTHKRSNETSIICPAEYSSPSKKRKLSSDSGKNEPDHFLSNSNSVRICGDMSVKDKADLSTTGHSFTQLRSQEVHMVNDGRKPCATTPPNTHAKAEEDSHIHKLKTSPPAWVQLNRCDSPDLFDDSGDSELLKDTSNKSGESSLASDNNVIDRDVGEMCKVFGDGNNLASRDISTVVSQEMYDSLGEAADGGSDPVEKELAPELSSPRSYLSSPSAERKLSLADNTTDCSANSQEQSLKFLSSDALIPQSDLTCKTKNYLPEANYLSCADTVTGTPSVCDKAYLTASSDQPTAESASSDPRSFHQVLKFSCSVHTGRIYVFDQEGTYLQANFLPVDVQVDNFSELPEELQHPLCKKLLQRFVGEWTELSDTKRRLLAKQGLVFSSPLHAYDLVKSGDKNKKRHLTKEDTLAAAQSAADALRGHVRVIGKRTTTLDTVSSDKVNEQAKGVAQAVVEDGTPVCLQCQKPYKNPLLSAETISNPKNAWQLRLCSYPCMDRYWILTHASYCRDQLFDIQRGVCQLCQLDAHSFITRLKCTKDLVVRAELLNKSPFRCLGSKQKKLIITQPSPGQFWQVDHIKPVWQGGGMCDLDNLRTLCTPCHLRVTRRQATQRANYRKLSKASSSGDISAFFQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1U7</accession>
    <name>A0ABM0K1U7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neuronal acetylcholine receptor subunit beta-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106749.2">
        <property type="nucleotide sequence ID" value="XM_005106692.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846911"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="181"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005106749.2"/>
        </source>
    </evidence>
    <sequence length="503" mass="56395" checksum="7494A6F28F96D278" modified="2025-10-08" version="1">MSLLASSYIRLNVYFKLVWTDELLTWNPEDHSNISVITPYSDSIWMPSINQGNTLSDEMVHLVALDDAFPVLLNSDGQVTWTPPAQLHTTCTLDMTKFPNDQHACTFFILLNSYPADQVYLNSSAGDSIISTSWLNDGQWELQSATVFTSSFMFLEDQNRSALSLMIRFQRLPTFFVLNLLFPTCALSFLNILVFILPASSGEKVSYSITVLLSMMVFMSTTTSVLPPTSLSVPLVTQFLTTLTIISILSVVATVFSVFVHHLRERQEAEHGMIVKVLQSLTKLKGGNELSSAHAQSEKKKKNGDGAGDTALFWRGKTSSKVFPSDDECLERASSIIGLDNERSVEPDQIPSRSPSKISTELIHTEKSNINFRNDESLPPLEEPPSYQVSETSNQWVKPKIFSNTLNNNNNQSSVAVFNEKTRTIKTANEEESESREKNKNQGEMCWNGKKLASTVNKSSSDYKSSDPQDGVNIMTRNKGLRLVFSKHLDTEEDQEYPPRRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2X3</accession>
    <name>A0ABM0K2X3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNAation factor subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101849158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107520.2">
        <property type="nucleotide sequence ID" value="XM_005107463.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849158"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1490.10">
        <property type="entry name" value="C-terminal domain of DFF45/ICAD (DFF-C domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003508">
        <property type="entry name" value="CIDE-N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306">
        <property type="entry name" value="CELL DEATH ACTIVATOR CIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306:SF15">
        <property type="entry name" value="DNAATION FACTOR-RELATED PROTEIN 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02017">
        <property type="entry name" value="CIDE-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00266">
        <property type="entry name" value="CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51135">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIDE-N" evidence="4">
        <location>
            <begin position="72"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107520.2"/>
        </source>
    </evidence>
    <sequence length="276" mass="31146" checksum="3EA9B1B7200415DD" modified="2025-10-08" version="1">MVKMISRWSQTSDTDTTDSVGVGFYECEELAHSGSYGSRSRSRSPLDWAAERRELQGQGTPEVKAKVKAESPTKPLKVWSWDRQKKISVTACSLHQAKMKGCENLKLSDDVDKVTMVLEDDGTEVEDEDYFPFMPADTVLMFLAGDKKWTPREDMGIDEPDAASYGEAWDSEMAGLLKGVRHDILRIVSFSEEQLQKIVDCDTALLSRYVGANERFTESLKEGCQRHLDERYRTSEIMNILEQLEKSPQAWSLAGGDRGDSNSRKRRHDDSNGSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3H6</accession>
    <name>A0ABM0K3H6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101856606</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107899.2">
        <property type="nucleotide sequence ID" value="XM_005107842.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856606"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038923">
        <property type="entry name" value="Centrobin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439:SF1">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1439"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1492"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1596"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1754"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1823"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1987"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2063"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1444"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1467"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1499"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1601"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1661"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1754"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1990"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2070"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2105"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2144"/>
            <end position="2154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107899.2"/>
        </source>
    </evidence>
    <sequence length="2178" mass="237373" checksum="435AAE7011B7EA3A" modified="2025-10-08" version="1">MDGQVDYNNLPPMGEDAVDGDESDPEEVAGAEGGTAQESSFGADDGLEQPDGQRNSLSLDDDGGTHFEASNSQETVIRRGGPVHDNSAASSPTQQDVSNDNDVVFNPAQRLNFEDDDDDDDEDEHYDDEVPENSSLENDNSGDGEFLTHRPVVNGSDVAEGGAYGGASSNSASDQGQNIRIIEGHDSSLIDDGSLSFGGFNFLQTQMVQMPLISPVHSGLGHSRMDDPGHNLYDSLERVDGASLFGDNHENVLENNTSEYFSAGSVSLMAANSQGPDTDSVWAQDDNSDHGSYLSHSQPQFHSHAGNAENHPSRHQSPPRNFQVDNSNMYLARKRGSGSNYALEGNMGGFGDVSNSVEDNSDVLSLELSEEGLLHNTQMYAQPVPSAGHVATGDNMATSRGDNMLLYQPQHLPEEMGGLRAANSGQAGYDGASGKVGNHQTQPKNLARNQSQSNSEPLHGSHTEGDGLDSHSDERQAGAGSSSSASDQNQSAGDSSGHQPVAAMRKSASGKVHSRRPAVQGSASSGNSKRSSSMNPRPGVNNPSASAAQTRKAPPPSSARDTGTGDVAMRGNGGARKKTPNEGNKSSAGLSSSASGLGQARHTQGQAAGLSPLTSRASSHTSLASNASSTNSRVSGVGKESHHQQQHQQQQHHPQQQLNPRGASSQAAGGTDVHHHLAQKLQETDVHHHLPATHHHPPPPLPQASGAGVAGLSGTNPHQSQSFERLRPNVAAAPPQHMLRGSQSLSKAHATTSAGHSQHQNTSGFTLEKNEPQLPQSGGQVRGAFQLHPASLSSQEASHPQQQQLMHPHRFMQQQQQQQQLFSGLPTGQERSQVVLPMHPGYSQGMSPSGSEGSHHSFNREMVVTQMDALRRQGHRLSPNEVSSQRAQLDNDLQGMEEVRSHLQNMLRIGTDVSVDASTFDQSGTATDLLLSDQPVNRQLHFETDSSSYLGNSQHEDMSDILENFPTFSSKMFSDMSAVSSRNDAVVHGEVQYLRESLEKERYRRKHCEEHIQKLNTKLLEIQQQLAVAVSTDKRKDIMIEQLDKQLAKVVEGWKKRECEKDEFMKVLSQEKEQIEETLQKQQKMVNNFEQDLAQTVEELRVEKEQSAETINSLKEELIESRQRKEEADAALESEREKFSKMSSEWEELRESRELAEGKAQQAQEKLVQEQDSWQTKEKELTAKILEVKEANQKVINMEKVKLEEQKKKREEVEAQSEELKTELKRAVLDMEQLVREKESQKVEMAIMEAKFESTQRKLETDLHAQMEKEIADQASEFHGRMESTMEEMSERHRKQVAEIHVRHQKDTERQMVALNEDREKKEEEYRRQITDLEEKLQDMRSENSSLKQSKLKLESQRMEILTKLQFMMQSQWNEAVSLLVSTPQKKNLNSSFMSSQSGGQLASAMAVTDGNTSVTSLNLVSSGMHPTAGHPARSLAQLEDTGGSRTLHSSTSSPPRAGGGGGGSREMGRGGDGKDRGEEDRMDRVEEYLHSLGDSRHTTNGSLPQPQGQQRSSPLRQGLQGSSYEGESEASQTSSDAHSKVLNKDIPSEQTQVHGYISGQNGGTLITAAGAGHEGHSGSGSGSSAELLLSQLTHQAVAMRSPQQSSSRHSDSIPPAAQDRSLRESHQSRPHPLTTGQHPYLLDSRYSQQNFPPPHPPHHQYPQHQQQQHPQQQQQNLQQRNYQQQQQQQHRPQHGSPRQQQPQSHLTAAFSTAVSGYHSNSNPLTQQQHHQAAGDLGDYKDVRLANGATSGNINIYSPESPTLTSSPAAMTTTGQWSPRSPGQQVKRFQAGGGHSGVNVMTSSLLLAPASRATNRNVALVPESPVKRHRGRSLSGPGSVGSADGMNESLSPPVKQTAERDHGDDYSDSSGGFHDSNRLLANYSQLSDRVQAHENRQGDLQHYVRMLLSKAPGSVCSEPERDVHSEQDILESSRDLTDQLACLGQKARSEVDLDLNDTAQAFELTAQLNRLQHLRERQGMQRRAYPGLNMDNSEQPSASQSGEALSGHLSDFMSDNGVISTQGLSEISHLLAVYRDQWETNPDQAGQENVAGQLMDALKGMASSMSKTGETSKQDERKVPMSKSSPKSHPMRKPKEISKVRKVRNTSQSADTSVTGDSAGSDKSMGSSRPPGPAMASSRKVPQPQETTNTTGVTAASRERKVAGGRQPKSGGGGPVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4C4</accession>
    <name>A0ABM0K4C4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101864332</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005108438.1">
        <property type="nucleotide sequence ID" value="XM_005108381.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864332"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18078">
        <property type="entry name" value="DEXXQc_Mov10L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049079">
        <property type="entry name" value="Mov-10_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21635">
        <property type="entry name" value="Mov-10_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase MOV-10 helical" evidence="15">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="14">
        <location>
            <begin position="382"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="12">
        <location>
            <begin position="602"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="12">
        <location>
            <begin position="710"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="13">
        <location>
            <begin position="795"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="518"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005108438.1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118507" checksum="9BFA8A718A1E96F7" modified="2025-10-08" version="1">MFSLISNIVGYFVGQTESQQDLKSAANSQNGNVLSPEYEQQELADAPFLVRSADATQRRAVDGKVTHVFHGHGLIDGHIYFSSETVAGNEKLQVGDNVHTVAVQFSEDGGWHAEQIHLTDRDWDAVAEEEDGHREVDLRQLQRNVAVGQVTSWCRGQGMIDKEVEFELEDCVDGYVPKRGDWVSANVEEVKETVAVEDEWSGSDVLIRRKAVHVQPSREMELDGSVTAVMRDHGYINGEVYFTLESCLNGYRPRKKDIVHLKAVESSQGQCEWRAVSIVPLSSEASAYRSKQFRQPAERPGQSWVVPGQRPMNFQKKLILPVKLPQFSVPDSLDFAVREQTELTDTVSCLAQVLSFRNYVTRMSTLLHLEEIQLQMDIREFDMNRVCLQPVGEFLALTVPGLAEGRPSVLIGDKVLLSSPSDPDGPTYEGFVHEMSCSAVHLKFTSEFHSRYSGEDYNVIFTFSRTPLRRCHQGVSMAVQYLGSPVLFPRQVKIRPSQVSQDVISSLSSITNHLSAQNAVASNHDDSSESDPTCQQMGMQQQQQQQQQQQQQHQHQRALYTQSRQDSAQKCEPFDPLTKSQQRMTGSNRRSHTKDVSFFNPKLNQRQQTAVINILAGQGRPSPYVVFGPPGTGKTMTLVEAVLQVLTRVPHSRILACTPSNSAADLIAERLFLSGAVKQTDLVRLNAFQRSLEAIPECILPVCRFAEDLRMIARHRVIVCTCTMAGSLYGLGLSAGHITHVFVDEAGQATEPESLVPIGLLCGGDGQIVLAGDPKQLGPIVMSPFAKMYGLELSLLERLMGRAEYQRDEVTFAEHGGFDPLLVTMLVSNYRSHPSILELPSRLFYYSQLLPLGPPAITNTLVTASFLPTPGLPVVFHGVRGEDVRENDSPSWFNPAETLQVVQYLQRVLKQDVEPDDIGIITPYRKQVEKIRMMMDRLNMPEVKVGSVEEFQGQERQAIIISTVRSNEKLVGFDVRHSLGFLSSPKRFNVSITRAQALLVIVGNPHVLVQDVNWRELLRCCRDRGSYTGCELPDLSVWTEAAQDSSDTATDGWQCDEVKTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5J8</accession>
    <name>A0ABM0K5J8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">RNA helicase aquarius</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101853414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109242.1">
        <property type="nucleotide sequence ID" value="XM_005109185.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005109243.1">
        <property type="nucleotide sequence ID" value="XM_005109186.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853414"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="5">
        <location>
            <begin position="49"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="6">
        <location>
            <begin position="517"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="7">
        <location>
            <begin position="731"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="823"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="1134"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005109242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005109243.1"/>
        </source>
    </evidence>
    <sequence length="1421" mass="165037" checksum="4156AE4A58E00914" modified="2025-10-08" version="1">MEESPFQHTTKAASKPEPMEVKEEPQDAKTPKTSKKSMAITVEQIQEDKITELAVENWGPEAKRKGVPFRPEIVEQIYAKEMIASNFSTKRIMMLEFSRYLENYLWPHYSKNKTSKSHIMSIAAVINEKFRERVPSWEAFKSAPEDFSQLFRQVLELCLSPSALVYKETTVILIFLIHCFNSLEVDLIRDRVQRLVSLPIWINLLPGRREALFKNNPKYKKFFNAFKKRDAKLSPEELNTVQFERNFLARLIEKFYSILDSIPLKGHADYNKVHYCERFLELLIDTEAQLPTRRFVNTLLDDRHVVVRCKLSQLILRKEGKLFSQLLSMLESYAHFEIDDITGEALNMHDRIDIHYNRVNALQTVVFKHYPDLQSFAIKNVASVDSKQSLIKYFEPLSSEDLHTILAHLNYLPPLESDVSPYSKSFLMELLIWKHERMRSQQEAINEMPLYPTENIIWDENVVPSEFFSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDALTHLKPWKAEDGHCLFGGWARMAQPIHAFNVVEVAKPQLGENHPAQVRADVTVNLSVRQEVKHEWEGLRKHDVAFLITLRPDVPIGYRYNHTKPFIPQVGLTYVRGCEIEGLLDETGKLIEEGPEPKPEFFSDNRTYRVWLDPNQYQMDMTRTVNGEEDVYETFNVMMRRKPKENNFKAVLETIRDLMNTECVVPDWLHDLILGYGDPDSAHYSKMPNTKATLDWNDTFLSLEHLKSSYHQHKMEVEGEPEKQVPPYRLTFQENSQEGKRGLESDENKEGSKVVKAVPHIIPNRGPYPYNMPKKNSIQFTPTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPSQRMLVVTHSNQALNQLFEKIMALDVDERHLLRLGHGEEALETEKDFSRYGRVNYVLAQRLELLQEVNRLQVSLDEMGDMSYTCETAGYFYIYQVLSRWEEFQIKIKPFMGQDEHMKKIQELFPFVKFFANAPQPLFRGKTFAENMNIAEGCFRHIKKIFTQLEEFRAFELLRSGSDRANYLLMKEAKIIAMTCTHAALKRRDLVTVGFQFDNIIMEESAQILEIETFIPLLLQNPKDGNNRLKRWIMIGDHHQLPPVIKNMAFQKFSNMEQSLFTRLVRLGVPTVDLDAQGRARASLANLYNWRYKKLGSLPHVLIRPEFRMANAGFQFEYQLIDVGDFNGMGESEPNPYFYQNLAEAEYVVAVFMYMRMIGYPGEQISILTTYNGQKHLIRDVIQQRCGGNPLIGRPHKVTTVDRYQGQQNNFILLSLVRTRAVGHLRDVRRLIVAMSRARLGLYVFARSSLFSNCFELTPAFNKLTSRPQVLHLLPNETYPTQRKLQEAPDESPIVITDMPQMAQFVYDFYNARVDDLKRHRGFLKANRLQAPPKKQVRSSDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5S7</accession>
    <name>A0ABM0K5S7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Small conductance calcium-activated potassium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101848323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005109394.2">
        <property type="nucleotide sequence ID" value="XM_005109337.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848323"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="Small-conductance potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calmodulin-binding" evidence="10">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005109394.2"/>
        </source>
    </evidence>
    <sequence length="231" mass="26574" checksum="3F61B768C075A9D7" modified="2025-10-08" version="1">MGAGCTALVVAVIARKLELSRAEKHVHYFMMDTQLTKRLKNAAANVLRETWLIYRYTKLVKKVNVSKVRTHQRKFLQAIHSLRRVKMDQRKLTENQSTLVDMAKTQSNIQELVIEMHGNQSTMEKRVNKIEEKLAQLQLNLDSLPELIAKSVTSAAAASRPEKTEMRMPLARPLSDFTGLRRTTNPRQRRPFQQQFSLREMPIYDRHSLTGQPNREEVDPDLQAADPDSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K754</accession>
    <name>A0ABM0K754_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Toll-like receptor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101848243</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110330.1">
        <property type="nucleotide sequence ID" value="XM_005110273.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848243"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017241">
        <property type="entry name" value="Toll-like_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037595">
        <property type="entry name" value="Toll-like_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046215800" evidence="12">
        <location>
            <begin position="24"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="741"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005110330.1"/>
        </source>
    </evidence>
    <sequence length="886" mass="100606" checksum="CA5E2C4B8032C480" modified="2025-10-08" version="1">MATKCLAAIVASIFVLCTPNGHCRSLTFRSQSDDDERDRPGSYDVFDDEVRGLSENQLKTKSLCSPTCKYCDCSSKGLTSIPSYLSEDVVVLNMYNNSVSELANNSLVRFPRLEKLFLARNNLSRLHERSFSGLVSLQHLSLVNNRIAMTEHSIPVGVFLPLQKLTKLSMERNNQNSTDPGLDYPHLALSVLGQLVNLSMDGLRNKTFGPGFSNMTSLRHLSIAGFVTGYCKLDVLREDTFIHLSSLHSLNMSDCFIQGSEVHHLTFTPLQNLKTLDLTFNEDFGLETFSQAVCALKNSSLTWLLINNIVSRFSLALRINRSHVDCLPTGLLALEATGNSIEIVDPSVFSALPQGLQLLNVGDNKFVFEHYLQYLWQLKSLKKLMLDGGSYLHNIPSKYPFSAVPHQHSLLQADQYSRDVIHVAQRPSQRGDLESSRECITFRLPPELEELEMSKASLKYNLSPIKFDKRNKLHTLKLDKNYFPSAVGPFEGLEKLAGLDLSRTNLACIKDSFFQNFPFLRRLNLGENRLNSTPDCLLKMSTFSNLSRLTHLHLDDNGLYHIRPDLFLGLHSLVSLKLNNNPFWIFETRIDHMAQLRELDLHLTAVRSLSPDMRRQIDSLKNVSVNMASAPILCECNNLKFLEWMTSSPAFNKTFEGYKCAFDGTKDRNITDGFQQILRNLQRECPKHIAIFFIILAASLLTTLIVVAVLLYRFRWKLRFLYYVAYQRYWDRCPQAEPGAFQYDVFLSYAFEDEQFVLNDLNPALSSLGLRVLIHGRDFRAGEYIASNIVTAVKTSRRTLVVLTAAQVKSNWCTYELQMANVESAYSGRPVLVFLIMEKIRRSRVGIELASHISTNTYIAFPPTAHRTNDQLMKAFYDRLANDLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K785</accession>
    <name>A0ABM0K785_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PrdX deacylase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101864342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRORSD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110396.1">
        <property type="nucleotide sequence ID" value="XM_005110339.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864342"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040285">
        <property type="entry name" value="ProX/PRXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31423:SF3">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE ASSOCIATED DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31423">
        <property type="entry name" value="YBAK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YbaK/aminoacyl-tRNA synthetase-associated" evidence="4">
        <location>
            <begin position="229"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005110396.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="62162" checksum="526A5BB28A318034" modified="2025-10-08" version="1">MACQKPRYGGAHNMEFVYTKSASENEKCTMEEWGLEAEPCQNVRKEKSGRRHGHDHTAEASPDLGSNITGGDGSSLCTVTSSRHAGGTSSSQTHERFSSSHESDNLTQEYKDDPGSSTSAHATVGSSETATGLDEYHETAYVKALMFCFQRLGIQACPKPYARLAEQPRSQSSPEENKDGRACSDYDDTEFTKTPKPRRDCKEELSGISPSGIGNASSETHCPAALLYCKNLFLKDRKGQFYLVIVSENSSVDLKQLKQELTAHRNLSFADKDSMWSILRVEPGYVSPFSVMLDSAKNIKLAIDRTLTASDTRLAFHPMDSTLQVEITFKELEVFVKSFGHTLQLLGKDDTSQPPMTGSKEPTSLKPESKKRNILNNNEITNVSTNSKPNETGVHKGEQSITNVSVTREVKATRERVDNESSTQLVGSGEKTAEKETHESGTERPKQTPFEPEPRTEKSKRRQCGSQPRIERPQQRQSEPDPGIERPKQRQSEPEPGIERPKQSQCEPEPKLKDPDKNDARKNQSEMKFLLRHNLASSHQHGLHTVQEQFRCPRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7T2</accession>
    <name>A0ABM0K7T2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110817.1">
        <property type="nucleotide sequence ID" value="XM_005110760.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849418"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005110817.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14196" checksum="040443F53B096EA7" modified="2025-10-08" version="1">MFILSSVYRTLVAIGDRHVPTKFRPLWEHPAGPKTVHFWAPGIKWALVIAGLGDLSRPAEKLSIYQSTALAATGTIWARYSLIIIPKNISLFTVNVFVGLTGYMQLARALHYRYTHQKAIEAGANTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8D5</accession>
    <name>A0ABM0K8D5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial calcium uniporter regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101850293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111219.1">
        <property type="nucleotide sequence ID" value="XM_005111162.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850293"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005111219.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34359" checksum="79997A370E708F51" modified="2025-10-08" version="1">MTIIVRLSLGRTSESALAFKSFVGAVKQGSVSRKSYSAGSSSSHYDDKLSLKTSERIPVPEQATNTPPVFTPQSLSDSKGQAPFPENDAVVEYKLLKTNFDDVLRDKSAESDPGSVLTSRHVDPTLVHQVYYFDTLAFVKKLEASGFSRQQAEGCAECLVEVINTTLDHQGRHMVTKLQKEITVQQLLAEIASVKKDMTLLQKTEFSSLKTDTEKMSFEMSQIQGHMNDEIVKLKGQFSLDINLERGRAIEAHAENEKRLQMLHNKIDTEVANLKTTYEVYRNDIFKYAGGTVIAVGTLVLGILRLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8P9</accession>
    <name>A0ABM0K8P9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854299</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111488.1">
        <property type="nucleotide sequence ID" value="XM_005111431.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854299"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005111488.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25012" checksum="FE228261FD32AAAB" modified="2025-10-08" version="1">MATAMADQHSQLEGAAYCSKERREQENRAKGHEEKKEELPRKKIVYAEDYNFPTAQDRLEDKRRLDRERIICPILPQNEETRRPREAGPLPLRFPDHADYNSREHDSHEEDAAFPEYEDEDEEREDVLNVDAFIGAFGAAIAVVAGENPQDEEYGEDPYDGYAAFIAALANMQLNSGDEGIGLEYSYMVEPEFEHEEAEDGDESDSGCPPPEYFDDDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8T1</accession>
    <name>A0ABM0K8T1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NF-kappa-B inhibitor alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111546.1">
        <property type="nucleotide sequence ID" value="XM_005111489.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847780"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111546.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45040" checksum="F3D608AE01F72394" modified="2025-10-08" version="1">MEDDIQADCEGYGHGNSRRLHAANMSTKKFNSIEDQEDSALGSLGYVSGDLNSLSIVDFPVVEEEKEQEQQKNNPSFDIVDSFRGLDIVGRAQSQSSQTDSNRCDSGLVEDRPSIDSVERCESNIRKEHWVSPNFSSEQVMDIFRGDEDGDNHLHLSIIHGLPEVTMQVIGLAPDGEWLSQTNNMLQTPLHIAVITRQVAVVRRLMCAGAFVDVQDQMGNTPLHNACRLGFEDVVRTLLTPVRYEETYQNSYDIPLQCIPQDLESKNYEGLTCLHLAAIGGHINVMRLLLFAGANVNAAEGKGGRTVLHLAADWGHIEMMKFLLSRRDIFIDAKTYAGLTPILLAYGRKHEDAVAELFSRGASCTTLLLTEESDGDTSDEEMVDESLYNHRHNAGRGRGFQLTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAP6</accession>
    <name>A0ABM0KAP6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Microtubule-associated protein 11 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113015.1">
        <property type="nucleotide sequence ID" value="XM_005112958.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853054"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055452">
        <property type="entry name" value="TRAPP14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031626">
        <property type="entry name" value="TRAPPC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16096">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16096:SF8">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23652">
        <property type="entry name" value="TRAPP14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAPP14 C-terminal" evidence="2">
        <location>
            <begin position="440"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005113015.1"/>
        </source>
    </evidence>
    <sequence length="692" mass="75428" checksum="3C809D22635282B4" modified="2025-10-08" version="1">MAAQVQSAEGSDCRDSNAKSFIDDIGVLSLEGFGSQGSQTSSRNPQDGISSSLPLSSVYLGETVRYEIVVSKHPSVRESSSWKKLISTISSQAVIVPLLSKQGTDSTVISERVERKSETCGPVKESGTASRVGTKNSSVDNPNPTNNGLLCSVLATFVGSTGSVSSSEEKDSSMSRPYFRDDDTFVVPMSSSLQDAPPECCRIRLSVTVWLYTVSVSTSPTSPEVAMEIGSTPLGSDSTTAATVPCPTTNGHRSASGQDPVMERANLADGQPCGSLSLESPVRVSSSFRSVQEKTVSCLLRIQGPPELTCRHTAAGLKHLLLLSVSNSTSGQMVIKSLQILSSSTPVHDVSVTTDDGSSVKWEHCHQLISLESPKHRQAFPAILQPGESFCLIYRLHLSSIPSESELSLRANIKWTHAGATSELTTLYRLPRIKIRCPPFIVTVKCDERVEIHKTFYVTYCISNQLHDFMSMRLYFNMDNMYRNLIEQGASGEEFEKVVHLKDSVVCHDPDIAISSCPRGSSVPIQVGFQIHQPGLYELSELMKVNLRYSLPEKPSPPAPPDSRESRTPSTDTSLSLQSPDDHLLASEELWRGRSGSTASLATPVLLQTAEERRRSFASKSYSFGDLGPTVSADSDEVAAHNKNKLIQRSPTVPPPRPQPPRMLSQTERELVRPSNFLKQPFYVYVQDPSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB43</accession>
    <name>A0ABM0KB43_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Receptor-type guanylate cyclase gcy-28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101856558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113338.2">
        <property type="nucleotide sequence ID" value="XM_005113281.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856558"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF8">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="9">
        <location>
            <begin position="178"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005113338.2"/>
        </source>
    </evidence>
    <sequence length="476" mass="54183" checksum="41A4F3B236F368FA" modified="2025-10-08" version="1">MSDDSKIWKVDLSTNHFSWLTSSHEMPRHAMMEASVDGRSEEGVKGQRRRCCNKRIFLASATSGYRHFVLACLAVILFLLTFDVTAVKGQPSAAPARPTYRFPSSTNLPNVEAPTPVFTSFSTANNNYNYNYNYNNNRITNYNNNNSSSNVPLKWPPVLKIGLIISYRGDFGISRTDVQAAITIAEQKILDTKFLLPGLRDISVNMKDSECSETQGPYNAIEMVYTDTVHVFMGPVCDYSLGHVTGYCNVWDIPIITPGGGSQSLDNKVEYKMLTRMQGRYSMLWRLLHSVMKKFQWEHIKFLYHDTGMGTSRCYHTAYPMYLGAQKYPGITPYAETFNENRLRQPYEKVLTEASLNARIIVLCASTEAVREIMIKAHELNFDNGEYVFFNIDLFSSDNATSMPWYNASDTPERNEKAKKAYEALMTVTLRKPTSPEYRKFSREVKARASTMYKNFTYGEQEVNSFVGAFHDAVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBD8</accession>
    <name>A0ABM0KBD8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Techylectin-5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101844977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113520.2">
        <property type="nucleotide sequence ID" value="XM_005113463.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101844977"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF254">
        <property type="entry name" value="TENASCIN-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046371376" evidence="1">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="234"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005113520.2"/>
        </source>
    </evidence>
    <sequence length="443" mass="49828" checksum="89E5BE42CA087650" modified="2025-10-08" version="1">MDANWASRKLILAAALFLSSSACVLNVTTPEVEVGQTANVSLECFNLYPIPDVSDIFVMRILKWDHDEWNSVAEIKSGDDAEVRQKSKDVFVEGKIGSVAESFLRLTWPVATNDTLGQYRCDLVSFTLQENVLWLKSLPLLVTRKGDLTVQMLSEIVEQNQNACFQQLSSQKQDILENITATAEVLEARSESQLKNQLQVLSDMVEEYIESMKAIVEKTKKEFLQQIGDLGAGSGSEIQPKPCAGVQGPGPRPVVVLSSGMKVVCDTQTDNGGWVVFQRRASADVDFYRRWEDYKNGFGNLSGNFWLGLEKVHQLTSQGRYEMRIDMTFEGKDYYASYKNFSLSGESENYKIYISGFSGNVEDNLDFHNGSMFSTKDRDNDHDYAQHCAEQFHGGWWYHVGCFHACLNGEWGSTVRAKGLHWVHLTGYTASVSLSEMKIRPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZU99</accession>
    <name>A0ABM0ZU99_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Alpha-methylacyl-CoA racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101860003</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092197.1">
        <property type="nucleotide sequence ID" value="XM_005092140.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012934592.1">
        <property type="nucleotide sequence ID" value="XM_013079138.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012934594.1">
        <property type="nucleotide sequence ID" value="XM_013079140.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860003"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012934592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012934594.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="40207" checksum="C99F80A8BF965828" modified="2025-10-08" version="1">MALKGIKVIELAGLAPVPFCGMVLSDFGARVIRIDRPSGVSIDRLARGKQSVSVNLKKEKGINVVKRLCQSADVLIEPFRPGVMEKLGLGPEELMKANTKLIYARLTGYGQTGAMALKAGHDINYIAMSGALSRFGRFGERPYPPVNIVGDFAGGGLSCALGILMALYERSVSGKGQMVDSSMVEGSAYIASFIDATNDMLFPKPRGKNWLDGGSAYYDTYQTKDGKYMAVGALEPQFYKDLLKGLGLEGSGTSQSDDQDQQRQLFSKIFATKTSEEWVEVFKDLDACVTPVLTPEEAADHPHNKERGLFIRGTVPELQGAPAPRLSRTGADGTERALPDCGANTVDVLLEHGFSETEINDLVSSGAISSNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV84</accession>
    <name>A0ABM0ZV84_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101859770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935159.1">
        <property type="nucleotide sequence ID" value="XM_013079705.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859770"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="238"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012935159.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49352" checksum="AFFE5F29848A46DE" modified="2025-10-08" version="1">MSDEQAEIKLEESSHPASDKKRDKDRKRSRSPRRRSRSRDRKRSRSKERSRPKRSRSRSPRKPRKKRPHKYWDIPPPGYEHITPAQYKAMQAAGQIPTEPVAPMPAAVVASTDITQVPGMSSLSRQARRLYVGNIPFGMTDEAMMDFFNHQMRITGLAQAEGNPVIAVQINLDKNFAFLEFRSVDETTQALAFDGISFQGQPLKIRRPSDYKPLPGMAENPTLAVPGVVSTVVQDSAHKIFIGGLPSYLNEDQVKELLVSFGPLSAFNLVKDSATGLTKGFAFCEYADVSVTDQACAGLNGMQLGDKKLIVQRASVGAKNAQQQAPVQLQVPGLNLNQGAGPATEVLCLMNMITPEELEDEDEYEDIVEDVKEECGKYGVVVSLEIPRPIRGVEVPGLGKIFVEFTSIIECQRAQAALTGRKFSNRVVVTSYYDPDRYHRREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVY3</accession>
    <name>A0ABM0ZVY3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101864052</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935646.1">
        <property type="nucleotide sequence ID" value="XM_013080192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864052"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047159017" evidence="2">
        <location>
            <begin position="18"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935646.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="52806" checksum="F58C768E8DE10703" modified="2025-10-08" version="1">MIKLLHLLLALWSCTVADCFLHPATQNCSDDTLWYRYQAGETITLQCPLAAGTSYEYIQWTMHLTQISVCTLEDSPTAWVCSHNELPGWRVSAYIQDSIVTLNLYAFPSVASEIIHVTGRRGNQSESQHRIPPGKVTPSLGVSPSPLVPSRMTSPSLKAGAEPNDKLGHSSKMSDKRDPSKQANTSTSKRSSAITDKITSFSSMLDAMAQKSVPTNVKKGAYGQTNTVTRRRGDRKKTSGISRRFANSPCGDIPRQLVPGAGRSAPFLHKSSAQRTKESKDAHAQQAFGDDVLLCSFCPFEVYSESGISCRAVDLEVDILTVDCALESSFSSPICELAIVPEQPSKQRDARATNSLREAVLDPASQLYHCLLTGRMSEGRARYSVIVMDRWHPRTLVTLVTFESSSVRLESDCTRHVYQGQAYVLRERTARCTCTATGGMPPSGIARWLKAYWGFATETNTSSSTLQIPWQAGKYVHHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWK0</accession>
    <name>A0ABM0ZWK0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein LOC101855007</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC101855007</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094895.1">
        <property type="nucleotide sequence ID" value="XM_005094838.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012935992.1">
        <property type="nucleotide sequence ID" value="XM_013080538.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855007"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005094895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935992.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13778" checksum="16828B8BF2CD57AE" modified="2025-10-08" version="1">MAGAYEGEVYSHGCKLVLPDLKFKDDIQLRSDPSVTVHHEKQRLLKEHYPAGKDRPDDYKIIIYNRTTRHQMVMNDSKDIEEYCSDLADDIELHIKENNEAQNQPARGHNLQTFGVALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYM8</accession>
    <name>A0ABM0ZYM8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854861</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937241.1">
        <property type="nucleotide sequence ID" value="XM_013081787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854861"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22961">
        <property type="entry name" value="DD_TEX55-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937241.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34684" checksum="083EF07568E01CBE" modified="2025-10-08" version="1">MESEQTKDQQQGQDEEQKESTTHSKNAPPEMSKDAPNRRQNKNPVDQSHETLMSPEPKDLAEIAPELREKLKLVSPDLKKPAASRSSGHGSVSSGEDDNHRTQAGGQGWDNGEDYDDSGAHTHGTTFRASRDDDPGEKTMQLTGKTAQGITAAASAAREETGAKCAGKGDGTKAMSLESGARAKKGKKKALRFGRQPQPKFTSWDVGRLGEHSMDHLPTYIERVPQIKEYIDQNILKKPEIFRQPLSSDVCSSDCAVKEYLEKHGICQLFRMLVTLLLYHKPERPLDCLIDTIREMARQYEAATCTPAGVKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ23</accession>
    <name>A0ABM0ZZ23_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Titin homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937472.1">
        <property type="nucleotide sequence ID" value="XM_013082018.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858022"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937472.1"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112665" checksum="4CAF18FAC91A6E3E" modified="2025-10-08" version="1">MSVSTQGDKRVPAASKKAQKSASTPTSETKVTKEEGQRELVRRSVSVEAWGRAAASKVRLEAKNFVSKSSTSTVARNDTSQAKSAHHDTLQPSTSSKEHVAEECSAQLLGKEGNTYIPHDRRGNLSSLGHHSISGKLGTGDEQKKEGTPAKLSTNWDKSAQKEGSAATGTTAVSGPRGKVSPTKQILSFSKQHRSQCASKSPPKRFQKSTTLSSTRLPSQTAPRNVPVSRRGGYFPGPASPVSCFGSLGAKTPSTPERNGVFASSPRKNEELRGTKNYIGTRKQHNVPRAGKVNEISPRAHVSSSSVPTRCKGAFTTLGNETKGVGAERHEENVPAATLAAALSLLKPATPSISQGERSAKKRLGRFLRRCKKEATEPKSQMSGAIDGNAEKSKDVEITNSVEEDCNAQETTKKEDTGRSSKPFANPKTRNGDVKTIQSQMGGQKVPDKTKDGKEDRDRPVDKLIGGRNRVQDAEKNKRLSTVVKESDIKSDKRKTRSLPRNLNLKPGSPFSLHNNHKHSSDPQSKQRQTVTGKAAKKRSQSDNRHIMSPLKTGNSENSSTPSPPKRPQGKGKKPQLLWGKDKIPAHSGKTRKSRDDALSSPGSPGRVQTHLPHGSKTNKKPSPVRNKDSKVPKRPHQNDSIIFSRLSSVESNKLRLNTKKKLFREKGLGVVSDKKSKSYIYEKTEEELPDKSRDRSVYSDDTDSSDSRDEMRSDPASDADERFGGSDLAELSDTDRENAKRLDCHLFTNQAAETRTTRGLTHRKEQPQALISGRNVPLTWSRSASNVVVYPKKQKSNARSVRGRSTINNHQSSRYGISRGGNDALRDTIVLSPRSKAHRDDFQGTMRNDRLSVARLGDSADVEPTHVYSSVSVSHPILSRSNAARSYAHIHETSWPTVGPTQHLYEDLYFDYNMARRDIKGDSPSSNEKTSFDVEMEMKEVIIGMYNSQYQMAETVMKLKDDFNRIKDDVTSTILLPPFRKEVEACWEGTLLDYLLLLGVMVVQILVQLFFLNLKKKIVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1V0</accession>
    <name>A0ABM1A1V0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase family AAA domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939116.1">
        <property type="nucleotide sequence ID" value="XM_013083662.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851418"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="163"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939116.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="44201" checksum="A6F3454A932A5CCE" modified="2025-10-08" version="1">MTILDDLSLLRTNLKDISSNVVSEVSRSVRGEPDIVMSEIQNGITRNQVIAKVVSTVLGVAASFTLTYLGIKWLTDAMDPTKKEKKLAQAEAQRMLSKLGVQNVGKLSDYELCVAANLLDPHSMEVTWGKIGGLENIIQEIQETVILPFQRADLFRNSSLLQPPKGILLHGPPGCGKTMIAKATAKAAGARFINLQVSTLVDKWYGESQKRAEAVFSLAIKLQPTIIFIDEIDSFLRSRSSTDHEATAMMKTQFMSLWDGLTTDPNLRVMIMGATNRPQDVDAAILRRMPSQFYVGMPDSSQRESILQLILQQEDTEELNYSQLSQLGEGLSGSDLREACRSAAVAVVHEYVQAHSRELEPTGNGDAEELRRMTMADLQTAIHKVKSTKALSARPLAFPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2Y6</accession>
    <name>A0ABM1A2Y6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stromal membrane-associated protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939775.1">
        <property type="nucleotide sequence ID" value="XM_013084321.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855195"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939775.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="70018" checksum="CD7B1A0B1F9928EA" modified="2025-10-08" version="1">MSSLKDKERAKELQEKFQAILSALLKDEDNKYCVDCDAKGPRWASWNLGIFLCIRCAGIHRNLGVHISKVKSVNLDTWTPEQVAMVQEMGNSRGRAVYEANIPDGFRRPQTDSALEAFIRAKYEQKKYIAREWIPPQPKVPKELNNKSWLEDSKAEKKRARAKPAGGVQLPSIPKATEKAANSTVDAPRQNTATKAEVKVPAQPEVKQASASNDLLGLDLGAPQQTNVQQATPAPSSGGNELFDFFIEPKPAETAANPPGQSSAASDLMNGASENNLFGNDNAQVAGSGEEKKSAKDSIMALYGGGGGGGVSQPQMYGVPAAMEMAGNVVPVPANSATQHFVKGSDDLIKMHDAAPGRNPGLFLPPASSFAQMGYIGQGQPVGSLGGSVGYAANNNFQTASYTSPVQQPLPTSSFGKQPVPFGAKASTNSQAASGNIGQMPGGITPQQHQHQQQTSAAGFGAASVGAAQSWNSYGGQVRPGFYGVPGGVYMPQGQQMYQQGMMGPQQGMMGPQQGMMGPQQGMMGSQPGMMGQQQGMMGQQQQGMMGQQQGMMGNPQGMMRPQQGMMGPQQGMMGQQMMNGSQPNVYNGQQQMMGANPGMYTPQQMQQLQFQQMQQQMTSMKLNGSQMGGVPQQAVPGSGAGSSWGAPNSGHTLSTNLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3Q0</accession>
    <name>A0ABM1A3Q0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine-rich venom protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940206.1">
        <property type="nucleotide sequence ID" value="XM_013084752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012286"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045035837" evidence="1">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="72"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940206.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21041" checksum="37E74FD35EBBB3F8" modified="2025-10-08" version="1">MVEMGSQFVFLLVIYAASVLGQSGDMDTFFTDYKDTVQSTDVWDVPGSGEGEATGKGECVIAVVFILEMEASGDGETIAKGKVWDDKLAAVAQKWAKQCVLEHDKNRKIPSYGLKIGQNLAAGHGNWRQAMSNWYDEVADYRYGENVNDYLGPDGFFKIGHYTQIDLYCLSKIHTQGNDRSTTRSEERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4K1</accession>
    <name>A0ABM1A4K1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-mannosidase</fullName>
            <ecNumber evidence="5">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Lysosomal beta A mannosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Mannanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101863684</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="5"/>
    <dbReference type="RefSeq" id="XP_012940722.1">
        <property type="nucleotide sequence ID" value="XM_013085268.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863684"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045349604" description="Beta-mannosidase" evidence="15">
        <location>
            <begin position="16"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="18">
        <location>
            <begin position="39"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="16">
        <location>
            <begin position="357"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="17">
        <location>
            <begin position="866"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012940722.1"/>
        </source>
    </evidence>
    <sequence length="934" mass="105180" checksum="63E75327BD37D48E" modified="2025-10-08" version="1">MFWFHVTVLIAAGISERMLTPHNFVNSYERVSLDGQFNWILSEESSGVSVAASVPGCMYSALLRKKLIQDPLYRDNDVHYVWMGNADWTYSRNFTVSKAVAGSSKVLLVCEGLDTVTSVVVNGKSVGSADNMFVRYTYDVTGIVTEGENRIVVGFHSAVREAATRAQRSSYVIPPNCPPQVQNGQCHVNQMRKEQCSFSWDWGPSFPTQGIWKPIYLDAFSTAIIRQVSAIPKKVSGQWQVDVDVICDVSGGTTVKGQVRVELPGLNLTLTQQVTVSAAQSRVKVVLKVPLVGDPHARDVLLWWPNGYGHQNLYLTNVTFTSGSDVSSREVKVGFRTVELIQDPVSSDTSKGLSFYFRINGLPVFLKGSNWIPADSFQDRITRDKLSFLLRSTAAVGINSMRVWGGGVYESEDFYELCDELGIMVWQDLMFSVALYPTYDAFLKSVATEIRQQIQRLKHHPSIILWAGNNENEKGLRQNWFKTQENYTLYYNDYVKLYVTTIKPIVNGEDDSREYAVSSPSNGKESEKEGYVAKDPGSELYGDIHYYDYAADQWDPTVFRIPRMASEYGIQAWCNNESLSGVFAPGDFAMDAPMVSHRQHHGHGNIEMAAEVGMHMDMSSSKDPAVKFADFTYLTQINQAMSMRTQTEHYRRFQSRLLYDGRGLTMGALYWQLNDIWQAPTWASIDYEGRWKMLHYYARHFFQPTLVSPYLRTTASLDVYMVVDQIPTVERRDENKGELRFEPMTDVEDLRRSSIPPQDVASTQAAVDRATTGRLTLTMYTYASFSPLKSWTVDYSMNTTAESVYTASVSQLLSEANCMSRENCFLHFSTTDKSNAVTSTSWLFLSYPKDAHLAPAHIKVSAVRTISPRVFEVDFSSDAVALFVWLSVGDIPGWFSDNGFLLHTPTTTVQFYADTDVTAAKLQATLRVKSLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A518</accession>
    <name>A0ABM1A518_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 13 member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101854379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940967.1">
        <property type="nucleotide sequence ID" value="XM_013085513.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854379"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012940967.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35318" checksum="2DA938C73226C7F1" modified="2025-10-08" version="1">MMSWLRDLALIWRTLVIVVVPLAALPVLLTDGSKEMSCLYGVILVAVFWMTEVMPLPVTALCPVVIFSLLGVLPARQIAPNYVKDASIFSLSCLTFALCVEKWNLHRRIALNTMLLMGSSPKWLLLGFMLPTWFLSMWVNNTSATAMMIPIVMAVLQELRLIQSKARGVDTNGYHDRDERGEDAAVEQHQTPGPEVKTTKNMAHTSKMAAVTSSTICSMFNMSDRSEESIEYPSDDFRNLCKSLSICICYSASIGGSGSLTGTSTNLVMQGQAEEIFGSYGLPSEINFLNWLIIALPVSMICLLITWIWLLVHFFGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5B2</accession>
    <name>A0ABM1A5B2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101857503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101857503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941110.1">
        <property type="nucleotide sequence ID" value="XM_013085656.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857503"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03156">
        <property type="entry name" value="uroplakin_I_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012941110.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="53501" checksum="1A521551F49A438E" modified="2025-10-08" version="1">MSVSRTSTSPSPSSLPRATLPHYSVTTGFSQGTFELPRFEEQRHRESLECKLTSRVRLLSAISDRERHYSRYEKEEQKQRGRDKERPRARRRAWYRRSIKATRVLANLRSALTLSMAVSLIGAVCLFTVGCVIRFYLSGILNQGLPDDRGGQIPSVFTSPLGQNICPSYPSFALSMDLSSWSLTMGGLIIIFAFIDIIYSLFGIFAAFRNTELLLATLTVILATSTLCLLILHWLLHTQDTSFHDSVKQSLTTQLQASYDKNVVSSDPFNLLMNTLMLMGSCCGVSGPKDFNMNLTFVFQRSKTANMSFHLPPAVVHLQVPPACCELSGIAHGRRVYHMTFYDVLACARQGLSNPHRLHTQGCYEAVYDYLMKEFHLWIFGLLIFLILWQIAQLVLTLLLILRPRCLLSVRFHRRARPRTPRKENTGSGKSPETKPQRKHTLHSPPRTFQPVAIVSSWVSSDITRVNSTEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5M0</accession>
    <name>A0ABM1A5M0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 16">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101861829</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 16"/>
    <dbReference type="RefSeq" id="XP_012941283.1">
        <property type="nucleotide sequence ID" value="XM_013085829.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861829"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012941283.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25117" checksum="191BB742EDA213DB" modified="2025-10-08" version="1">MTDNIYFFVPNIIDYFRVVFAFVSFYYMPFDHVRASLFYLLSGFLDAFDGHFARLLNQSSKLGAMLDQLIDRITTMCLCATLCHLYPSYMLFFQFAMALDIFSHWMHCQGSAVSGQTSHKTIDLAKNPILYHYYHSKVVLFTMCAANELFFCMLYLMYFTTGPIVPVLGVGLWKLVAVLTGPLACLKGVVSVVQLLAACENYAIMDRDDRQRMKAEGKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6F8</accession>
    <name>A0ABM1A6F8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">B-box type zinc finger protein ncl-1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101862821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941716.1">
        <property type="nucleotide sequence ID" value="XM_013086262.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862821"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00021">
        <property type="entry name" value="Bbox_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14959">
        <property type="entry name" value="NHL_brat_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="456"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="525"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="582"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="1074"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012941716.1"/>
        </source>
    </evidence>
    <sequence length="1198" mass="132533" checksum="5081897218F7007A" modified="2025-10-08" version="1">MQRPGSPPSPRSILQRGHPSQTHPASHYLWHPGATDLRRMAMVGSSPATQNSSRPSWSSAPQSSTPPEAEENLPQPLSAMAANLHGAIGEHRRNSRSSSVSSGGSSGNGGEAGDSTRQQAQARLSAMPQPSPADPSLEQQAKHILQHLDMHPSGDDPQDLLDKDKAAQMVGDSQASILCGKQEANTTEADIVSQLSLLSMASTCTQSPANTVQLGHLMDAPRSMEQQAFSSGVTGPASGTTAPGPFSSSNPMDMVNVVGGYVQNFQTRVQNDFDVMGLSKFFDKYQSNSGSGMATGGMATGGMATGGMTAGAMGGAGNMAPSNEPSSMGSGFQTSTSPRGFQNVSSGFGHGSSQQFMNNSNPFPPMGNNVFSSGQNMSMSNRGSSFYSPVNNYSSGSNFFSGQNSSNNYFSPSQMPPFQTFASPQDFSLPPPPPHGWHSGPFSPNMSDPIMDRVMCRGCQKPYKWPMTLDCMHVFCFNCISNKINGTTQTICCPFCNRTSSVPQGPQKLLLDYALCRYMINKLKMNPFFCTSCSRENEAVICCTTCPAYLCHDCQTGHGTMRLFSSHKLDPITKVVINLNGEFEPMCERHYQKPLTKYCVTCPQMICDDCTTDHLHPDSSNNHDLQESYNIVIARLRNWNEDACIKHKEVLELKKKIPDIKNSIENKKRVARRNVDDYADYLKNVIEQNRAVSHDMVERAAEQMESQLNKFSKLIDDIESELEAVSSFNTFSVDEGTPSMVMTSLINMESSYKRAVAEYSEICQKHSSEGMSFEFTFNPDYPRTNEFIQENFSTVTYKINDSEFNVGPMPIRTELSRGRNFPEFGHSDNPDCNYQRWSAAPDSMSISTWNSGNERDRKGTFIPFLNRCRTRTSFVHVFGDYGRGEYAFTEPSGQAYFEDGSYVICDTNNHRIVYYNKDHEYVRSIGQPPNLPALSEDHEMGKGGQRGKGFTRQDGYLYFPNRVAICPVTKHIVATERPPSHDVQIFTIEGDFVRCFGGSVLQHPRGVTVDENGVIIVVECKVMKLTMFDHDGNQLASHSLAKDLEFPNDVAAKDGKIYISDNRGHCVQVFDYDAKFLQKIGNDNLTYFPIGVSINYLNQIVVTDNHNTFNITVFDLEGRASYIFESITKHAQCHNVAVHPTKLELMLTTKDCNVYFFNYDPNSQHPPQAPTSRGSNHFLQTRRARSNGNGNHSNSSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6M0</accession>
    <name>A0ABM1A6M0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neurexin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101858681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941838.1">
        <property type="nucleotide sequence ID" value="XM_013086384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858681"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF89">
        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="45"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="259"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="437"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="480"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="658"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="842"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="892"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1634"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1676"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="851"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012941838.1"/>
        </source>
    </evidence>
    <sequence length="1764" mass="192773" checksum="51DB0E62EBA84358" modified="2025-10-08" version="1">MHGPKEISYTLKILIFVIIVLGEILNVSAQNSSVAVTNSPTSKKQKIIYLDGRAFVQFSFNRLPTQYLLPAEVEQFQIFFITDQPEGLMWYQEDPERITFLAIKNGYILFVNKYTTGSRSDEVTIGKDLSIRFDDNKWHDLIIDRRGKRITITVDNKYRARYTFSGFAQFLTQADVSIGGAHNVGEVTEGRVFSNFKGGLGQCLYKTEVRDGYKDIRNEVSLIAEVSDEKEGIIIREIDWFPTDVVNFPTTPRPVPTLTAVTIRDEGVHFVLPETFEPRPTGTLAFKFQTVKPNCLILFSSNPTGSKFMALELYDGNLYLVNRFGQQAIRTLLLEDAANGKPHEVSLGFGVRRITATTDRNTERIRLPVSDTLPQTLGPLYVGAMPKMDSLPWYTWARTGFQGCIEDLKLNGTIIDLQPFLQNQQLSGRVDPTCTDMPQQCSEDFKPCANGQCVTYWGTYFCDCKYTDYSGKLCEIPAWTGVYDGSTYNNLNFRPQQSFHHDDISFRFQTMASDGLIFQTHARDDEGYMRAELDDGRMKVSTNFGGQEEDVYIGSNLNDRNWHTVYIQRRGGSLWVWLDENINQAKVLPGSGYYHLVDDIVVGGYDDENWVATYGDPEYFIGYIRNFMMGGYNILEEVKSSGGINFYQEPNIPPLIFQDVTFPTYDTHLVLPSLGVVSGIDINFLFRTFDENGILLLSIKPSGNMFVVELFRGRLIVKFRNPGKAPVEVITPDGYKYNDGNWHSLSLKGELVSNKKQLVVNVDRLSSVHTYLGMDRMKLDGPLYVGGAPDNVIENPNLQGFISSRNGFRGCLASFDVASSIYDLFDYGQTQGVNILDACQEIKSKCTEDTCKNGGICHDNLNNGTTWCDCSKTAFGGPLCADEPLGYYFRSLGDPDLYGAMLYNYPPGEQKNSNQDEIIMGVMTDEKNAVLTRLASSNLNDYVELKLVNGYVVATYDTNGQGSSTTITNGDVMVSDGNYHIVRFLRQSDKANLTVDSTSANINHLSNHDNFNRLGNVYVGGLYKDNKMINGTGFRGIIGGLYVNGHLILPDASRGKNTDIFSDAVVAPHPFQLGPLKTTEKPNWVTEPPIVGPTPDKKPFDVIPVLPPGVGGGGLAFGVGGGPVDIVVYPGGSGGTAVGAPAAAFPLDGSAASAARASLSVIPLLPAKGPRAGALMGIILGIMAAISSLIWAFYLCKPGCCFGGSEAPLTISEPNADASAPFLDAIPLADVGDTGKFPLLAGDAGAGGGGGGGGGVDLVDSGLVKGGYGGSHTLNATRSHLASTASAGAFSVNDHQIGVLSPTSLQSYHFEGGDSATADYDIAIGVHHPNYKSSTLPVGRGGMGSGHSTSTLASNYNYTVKTARSLGAYSHTMGYASSTPQIIVTPGPMGEEVRVDCCLMTGNGQSVVTGSSLGPPQVWNMTDGELLRIMHGEIRGSTFLHLVNNENLLTGAINADLEINQYSVPKGVHHYLFQIWDFATGRPLDMAEPEVCAALTVMSDNDKVVFGRSDNFGSGTNIIVWDLLANQPLKEMRYDAPVGNNDYLSYINLSQNDRFVIAGYSNSLDNQAEFVVFDMTLTSYSINDPTIMRMDAVPECTAVLPHDEAVTGLRNGELVIWSLRGAQTTRFLVSHNSKTAHAREVKAVARSENNHYLVSASADGTLKLWDLHSERLLATLSGHTDEVWCTAISADNEVIVSGSRDGNIRLWKLRTAQEICAFNAGVDVFYITMSQDKSTIVALGDKYGARKLIMLQVVRSKIKKQVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7C9</accession>
    <name>A0ABM1A7C9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger CCCH domain-containing protein 13 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942263.1">
        <property type="nucleotide sequence ID" value="XM_013086809.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852497"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039190">
        <property type="entry name" value="TTC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="116"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1446"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1616"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1833"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="846"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1276"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1332"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1370"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1504"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1616"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1631"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1661"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1692"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1712"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1734"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1766"/>
            <end position="1778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942263.1"/>
        </source>
    </evidence>
    <sequence length="1899" mass="215610" checksum="88B9341437ECB5E0" modified="2025-10-08" version="1">MDVKQIGKAVQYHGVALLKKLGEEQQEAPSATILSYLSKREPQEPEIRDEHFQNKLCSFIAKKSDLLFRPLSGEDKETTSKDNIDDAYAIMPPLETFMDLPVPVRREHLYNTLHVDDCVTGVVSQILENGLLIRLLCVDKFQARDIEDLEAMAYCPAKELPKLYANESALDAFQEKDIVRGIVLNVDAKTERIILSLHKKAVPDEKKYPRIGLITEAEFPVHYRRKSQIQDMPYEEMIHSVLGFNNSGNVKALLSELDIPDTASYLRFHSRLRIPEKEYAEGLNKWQSQKLAHQSVAQGVEFFKQGKELEAMQHFSRALQIDPTNVEALVARGALYANKESFHRAIQDFEEALAANPRHNNARNYLLETLLTYGKSCEDDREFEEACVHYQHALKVDPGNVEAKDMLAGCQRLMVIQKQQEGSKPGAEVEKEKTIDVDVDVGQSLISRTAEKLKQLIQEDRKKSSSSAKKKTKKRWSSSSSSSDSGHSGLRKPQHRRSRSSSSSGSDRRHRRKSRKVSGDSDRSSRKKGKRRRRSVTTSPPPRKPDVKEEHGERTLTREKSPVEDRRTKDSLMVKTEGGAETEGFSFEIEPKVTTSFLPVSSRDYFSTTTRIPGLGSPENADERPPPVKRSPQHRTAQLLMTERRKFYEDNARPPQHTFRGVSSSLATGQRRSRTRSPQGSRSRSAKRSLSRSPQRSMARSRSAKRSPSRSRSRSGKRSPSRSPQRPRSRSAKRSPSRSPQRPLLGARARRSRSKSPREGTGLKELDMYLGNVRPSKDKDSQDILSAWESFIRHKEKPSPPPARRSRSDSRDSVGSRSPYSSPRPRYRSRSLSRSPAAPPLSFRQDYGDSWRGERREGDPGWRERVYNEWGGRRGGRRGGGLWSGRGGYRSPGRERVVPRDRDRGRLSRSPPPPPVSSVAANRFDHQFPSRGGYGRGRMGRLQDRPGRPKTFEESPRGIDGSETGRDKSVFVEADSRPSFSQGLVDRQMSQEQFLRWRERQEKYEATVSLNLDERREGIRADQQRRSQDVGEEGKRVRGEELWGGREEKAGKEERAGREERSGREERVGREGGPGREERRSLKDAWTSIHKGRSGDREPSDLAEDRVRLEGQYATSKNPDGGQREREKVKDQGREERDGSSLSSRKLEDGYAYGGPREESGRRFQEERERSRESSASQKFAVEWRQQRERSRESSASQKFVVDSRQQMEEVGVSGGGTSAVEDEVKPSRRRQEVDEEGGGSGKLGTGGAGPRIIRKPVMDDPNLNRPMLSSNELAVLERKKREEKERLRQKYAETKPDTAQDGSENFKGGESKRASKDRRGEEEESDGKTRRTDRKKKKRRKSRDKDKKRRRRDSSDAGDDEEEKKKKKNGENDKKKLKIEASKSRGMPDDDRGDGKGRKGSDDASEGGEKGRKSQWLDEVDLEKEIERRVQQRLREEEARLKEVALASQGQQEAVGHEQGATDVPETATDGESSDTLAAAAQEAQKASRWDSKRRASGQNSVDVRDLGGDKSEKKGESEEEQERDRIGESEGKQEGEEKGENEGKGESEEEEEDNHPEVFIETQSGWCKDMKGNMYYARKWEELAVGWHEDKHGNKYFAHAMDRESYQEAIEGLREEMSEREREREAWRSRARGRGYGRGRGRGFFHGYGARGRFEFNRRSRSPKKSRSRSPKRSRSHREKRSRSRHRRNSSPSSVSDSLKPRGSPRSRRSKDGRSKSSDKKKAEKISAVADKSVKAADHQKSAEPSGRTGSGGPEVADPPVADREDETGVQEEETEVTFVVGTRGDNKLFATADLREASREQTDDWDDVENENWREKVPLKSALKVTPASRWDRMPGVGESGGHSRWADDASVGLETDEVGGKTSEESLTELEKFLRNLKQMKKKQWIAEGKVKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8H6</accession>
    <name>A0ABM1A8H6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chymotrypsin-like protease CTRL-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106012959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942857.1">
        <property type="nucleotide sequence ID" value="XM_013087403.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012959"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045235609" evidence="3">
        <location>
            <begin position="28"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="193"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012942857.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="47295" checksum="115942934E266FF1" modified="2025-10-08" version="1">MKMGTSFERLLAFAVALCTVFLERAETVTVGEGRCSWEDSRNRGKTWCPISQARADMTLKVTVVSGWYSANCVEGSTYKIQPYQNQIYLEVYYPCGAVFRIDSVGTTAAPTTTTTTKAPAVWGPWSAFGSCSASCGGGLRSRSRTCSTGNSRDCVSLTSFAVENQACNTQDCPQTTPPSATNAQCGVANSFRIIGGTQSGQCEFPWMVMVYNVFNGTVCGGSIIDQSTILTAAHCLVNKNELGKDITVTPNQMIIFSGSSEMPFVNAIIPGLRRTGVSTVTVHEQYNINGRLDNDVAILKLSQPLTFDRCQRPICLVDGSKTPQQASGCKTMGWGKISNELDAKPQANMSWTAVPILTDSKCGAVYGSQESHQTFCAGKTNHDACEGDSGGPLVCQEADGRYYQYGIVSAGIKFNCGIFPGIYTRVSTYLPWIESHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8I0</accession>
    <name>A0ABM1A8I0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-xylulose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942862.1">
        <property type="nucleotide sequence ID" value="XM_013087408.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848607"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942862.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="30332" checksum="BC8E5CA2047B26B9" modified="2025-10-08" version="1">MVRQFEDKVAVIVGASSGIGQEVACLLAGKGAKVVLQGRDSGRLEESLALCKKSNGSAKSAVGVTGDITETETRKKLLDKAIHTFGKIDILIFSAATATPNKGIVDETEESFDVQMTLNVRSPFFLVQSAVPYLEKTKGNVVLVSSTVAYVPQAFMTVYAMSKHALDHMTKCLALELGPKGIRVNTTNPTITPTRALRKHDEVYGCDFMEFAQKYNATLHPLYSRCSTVKEQADAIVFLCSEQASFVTGQHLYVDGGYIHSKGNPPPAPDAGENGQEQKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8S9</accession>
    <name>A0ABM1A8S9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106013003</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943021.1">
        <property type="nucleotide sequence ID" value="XM_013087567.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013003"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35555">
        <property type="entry name" value="ENDONUCLEASE-REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35555:SF3">
        <property type="entry name" value="ENDONUCLEASE-REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943021.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24401" checksum="4BA6582F5646FE0A" modified="2025-10-08" version="1">MTMEGQVLSDVLEVSAESYPTSEKEEKGGEEEEEGGRGGKADAASVPGAGVEECEGQGSSPARGISWQSSTLGGDRPPVMRNEDLMFTYFTLLRRLASTSRLLQRWVASWISFVLLWCVLYIVYWISHSAHLAGILQFLTPLLTLALLTSAYAEVNFEGERLLKCILPTEERLSVFFYFHKIRLELKIFSFTMTYNSIVTVIAGITITFATRIILDQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA65</accession>
    <name>A0ABM1AA65_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013216</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943779.1">
        <property type="nucleotide sequence ID" value="XM_013088325.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013216"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943779.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33431" checksum="0BC920C7C98F2259" modified="2025-10-08" version="1">METDEAKGRAFLERYIKQTHQGNMEERANIRAIMTTAVPGVQYGEGVTIQDVKRVISGTKDSAAGPDGVRYSYFKDADEKDLQGMVEDFNESLAKGKILEEWLHSYLMPLPKPGKDHSNIKGYRIITMQNTYGKILEKIVAKRLAIYLEMKKLLPDGLGSYRPGKDTCTNTAVLAYDVVEGFQRKEETAMAAIDLEGAYNRVDYGKLMDLLMEMDVDPWLIQWISEALFERKVVLRSGRWMSDPVVIASGLPQGSALSPVLFNIYTSKIARIGVSGAGRILTFADDVMIYGEGRDRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAF2</accession>
    <name>A0ABM1AAF2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101845958</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943942.2">
        <property type="nucleotide sequence ID" value="XM_013088488.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845958"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943942.2"/>
        </source>
    </evidence>
    <sequence length="248" mass="27481" checksum="7DC2DD605BF6C124" modified="2025-10-08" version="1">MIGLRGISAIAEYPELVCLVSISPQELAIIKNSSRQSSVLTKNYTELLCLSSDVFQKYFMVGGVKNMNDPDQYNFVRRGSIISRDSNYSDWLVIVKSGSLNVLKKLVKAKPTVSRKTGKPLVTSDTNSYMSFLNNGNEYARSLEQNNTSLPEPIGDDLPDNNDNDENCNGAADDSLSDVNDDVLRKVKMANRPHTTAGKRTSTQSTRSLWSASSHSTLVEFKADTLLLRRNKTETKINTKPKAHKATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABK5</accession>
    <name>A0ABM1ABK5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101861994</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944562.1">
        <property type="nucleotide sequence ID" value="XM_013089108.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861994"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF13">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046450087" evidence="1">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944562.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20953" checksum="27788D1D873A450F" modified="2025-10-08" version="1">MKLLFLCVALLPLITADDAKPCCMPRKLEGKIFGTQELSLFDMARDADLKMIVLRNAKDKTDPSYTLIDYGKRLIYRRSKDYSCTKTTILQPQMFSNCVPANAKLLAPSHYGPPGVLPINTFVFTMGNIKMEMMMSVDRCYPVVNRLFGPNSPNGEALNIFLSLKPTISDMNVFNVDTSNCTAPLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC50</accession>
    <name>A0ABM1AC50_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944888.1">
        <property type="nucleotide sequence ID" value="XM_013089434.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013509"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLC-beta PH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoinositide phospholipase C beta 1-4-like EF-hand" evidence="2">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944888.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23712" checksum="553A91DD56F5CF78" modified="2025-10-08" version="1">MAGAKPGVHQVQLKPITVPETLTKGNKFIMFNDNSTIGTPVTLKVDENGYILYWKDQNKEMDFLDISLIKDTRTGSQVKIPKDHKLKESLMIGKMDVPLEDKMITVVYGTDMVNMEYVHFVCAHMETAQEWAQELLDYSVNLLALNSCALTYLDKLFARFNLVLNAEGKVSMKNIVKHIASNRDDRKKVEKALEAVGFHAGKVSTCFCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD95</accession>
    <name>A0ABM1AD95_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial thiamine pyrophosphate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101856390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945487.1">
        <property type="nucleotide sequence ID" value="XM_013090033.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856390"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="216"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012945487.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35293" checksum="AEAFC810260F13B2" modified="2025-10-08" version="1">MVGYNPLEKVQLSHTEHALAGAVTGAVTRAGCQPLDVLKIRFQLQVEPLTKSQSSKYQGITQAVSSIVKEEGVKALWKGHIPAQVLSILYGVVQYASFEVLTEGCWHVLPAWYCTRYRSVNHTICGGISGCLSMAFVHPVDVIRTRFVAQGEPKVYKSAADAFRVIVRTEGVRGFYRGFVPAMSLIGPQIGFQFGLYSLFTDLWHRAKGLWGGSPPESLESLLCGTGSGFCSKLLVYPLDVVKKRLQVQGFEAARRPFGAVRHYSGMINCLVCVVKEEGLRGLYKGLSPSLLKSASVAGLNFCLYEQVRNALIRYHLSQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE24</accession>
    <name>A0ABM1AE24_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106013800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_012945917.1">
        <property type="nucleotide sequence ID" value="XM_013090463.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013800"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF364">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012945917.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41545" checksum="F21D9064040B9F45" modified="2025-10-08" version="1">MESNDAQKRYQITGQNGFISCIMSCNVTATDTDDSRKAACVHRCQAAQTGFETHDIDSHLRTPSPFDTSELPDTSGIDPGLTSYLKRNIQREIDRRNAVLTLLTSPVINAREYTYLHNVPDLCQRSETIILFVIPSALTNFGKRARVRSNNYARFVKDTQNKAKMAFFVGMVPASFNDTYRYQVQKRIDMEFAQFGDIIQADYEDEYSNMWYKTQSVLKWVTSYCGSVQYVIRTDDDIQIHTHRVLAALFFAEGHHDHFVMGVRRRNSKPQRIDTGKWYISLEEYPEEFFPPFVIGGLVGLPGRTAKLLYEASRRVSKIWLDDVYFTGILTHKLNLPVLSDPDFTFAHFPKGNKRRVPQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE60</accession>
    <name>A0ABM1AE60_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein kinase Aurora-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945970.1">
        <property type="nucleotide sequence ID" value="XM_013090516.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862549"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945970.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37906" checksum="5E7933DE6CC7BCAE" modified="2025-10-08" version="1">MELLADRGNWEVIVAGRVRQPKVKRVLKKFLLFEDDDDTSRMWKRSSFEHELSFLQSLEHHNIVRVLAAFQCPSYLGFAMGYHPTDLSHGLLDVTYFEAESYTSQLTDVMCYLHGQRIIHGDLKLGNVLLDRAGRVKLCDFGHSQVIPEDTDKPDGWGGTNGYQPPELYDSQVHNAFKMDNYSLGILLWALFFGTAPRDNIDYLKEVDNGSFLKPQHKHCLQRLLALSPTHRAYIWEIARILKDEDTSERYVSKGSVCSLSSESSSDSAQANQSSPDNGSSVTERPESAAVWNQFLAPPPPHPQATSCYLLPQTAYPDSGDVPASLAPTWPPLHQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEN8</accession>
    <name>A0ABM1AEN8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC106013914</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106013914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946233.1">
        <property type="nucleotide sequence ID" value="XM_013090779.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013914"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012946233.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19145" checksum="6DE929A56A03A7AA" modified="2025-10-08" version="1">MTTCCSVLGLIFLVITNLTIIIAFATPYWVEFGSGSSNQGLWAYCRSDQCTWVFEDHYKILSPMKVSEGWWIATLGLMCAGLALGLLALLLATIALCCDCRGCNASHAIGGMLLTAFLALGVAAVVFGVCANKYYSVLLEATLLSGKQFGWSFWLNAAASGLALLTSFIYIIEGRGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEQ2</accession>
    <name>A0ABM1AEQ2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101845067</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="RefSeq" id="XP_012946259.1">
        <property type="nucleotide sequence ID" value="XM_013090805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845067"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="282"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012946259.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56094" checksum="DB07C7208C2916A7" modified="2025-10-08" version="1">MNGVIQVDPFMLSLWDVCCKVRESGIKQPLHLGLFRNDFMMNCLDDSVCPGQIVSADRLELKQIEFNTVSASCGGIAGQMADLHRAVIIFVVSTSERNVIDQRWVEFKVYDRNPNIRILRKTFLDIYNHGHLDDHSRLIIVIQVDPFMLSLWEVYCKVRESGIKQPLHLGLFRNDFMMNCLDDSVCPGQIVSADRLELKQIEFNTVSASCGGIAGQMADLHRLSLGMAGKDLKPEQLPDNKPAVGLADGLVKAWELYGNPRYRVTHLMPTSLELVESSDILDGDEVALIYLRDGYTAENYTSQKEWDARLKCELSRAIKCPSVQLQLTGAKKIQQELTRPGALERFVSDPQVVNTLRDTFADQYSLDLNQEGDAAVKLALQSPEKFVLKPQREGGGNNLYNDDITHFFKEHNGSKERSAYILMQRIYPWQQKNYLVKPGVPFVLSDVVSELGVFGAYIGSADSEVVNFECGYLMRTKIQGIDEGGIFAGFAVWDNPLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEW8</accession>
    <name>A0ABM1AEW8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106013959</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946359.1">
        <property type="nucleotide sequence ID" value="XM_013090905.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013959"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946359.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="23846" checksum="37A91867827E3565" modified="2025-10-08" version="1">MCGPASGWSKIALLVLVLGICIHIAGWATTNWMVYSTTSGAVDIEVGLWRMESCTSGVCEDTAVASQYETGAFNGVRAMETITFCLAVFTAILLIIYMCSQMESRQTFAAVIMILLYIAGGASFIGMVIFITTIPDPFEVSWSLGLTVIAMTLILIAGTLMIPDAFEASYDDDSDVEDDDDYFGTSRRNAVSPSMRGNGPSSRGITPISYRGEGNRWRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF13</accession>
    <name>A0ABM1AF13_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable serine/threonine-protein kinase DDB_G0282963</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946426.1">
        <property type="nucleotide sequence ID" value="XM_013090972.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013994"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946426.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12759" checksum="96DA364AAC82AA55" modified="2025-10-08" version="1">MEDRFEELTRRLQAERETISQHARPTLSPGADSDTASSMASITSTDDSFRYHGNHNYNHPHNNSSSDQPPPPYHHHQQQHSNNNNDDNSFQQPLPGHSPDSSKMSSHLLDSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF25</accession>
    <name>A0ABM1AF25_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101849030</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946443.1">
        <property type="nucleotide sequence ID" value="XM_013090989.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849030"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF15">
        <property type="entry name" value="SLL1173 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="136"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946443.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36468" checksum="02BE70B0B2792844" modified="2025-10-08" version="1">MGRAVQLQMKVVAALVMLGVTGVMVRYIALPQPLAAFNEKLQLNRASLGEGAMVRSASALHASVNVVKSYPTSELPYKDCVPLPESPRQGVVMCVYPPENDIFVSKYIKSGRLFERELVLEMAEALKADPESQFVDLGANIGAYTLFAAATGHSVLAVDMLPANLHQLQTSLSLSGLSGHVTLVNNALYSDHRQLPAHFVSSNVGATHLNVSKTDFDHYGMVVDRNHTVKVNTICIDDLTPLLKAGTKTLVKMDIERTEARALTCAHNFFQKLDIRVVQMEWVAKTREEMVSINGFMSEHGFKPSKHALRYEPEDTWQATTPGNNVFFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF99</accession>
    <name>A0ABM1AF99_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106014061 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118479088</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106014061</name>
        <name evidence="4" type="synonym">LOC118479088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946545.1">
        <property type="nucleotide sequence ID" value="XM_013091091.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829625.1">
        <property type="nucleotide sequence ID" value="XM_035973732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014061"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829625.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12155" checksum="CB5DEAC70BAC92F9" modified="2025-10-08" version="1">MDQTEYILFEEMYSGRASSHVGPYKRKEYILCQEICCGRESSPVGPAERKGCSALLPSHHHPGKGPTLEYPKRGVSNGPDRFVFDLMSKREVKVGWEVGVIIRNVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG41</accession>
    <name>A0ABM1AG41_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine-rich neurotrophic factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946976.1">
        <property type="nucleotide sequence ID" value="XM_013091522.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851105"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045313784" evidence="1">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946976.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12816" checksum="3C84E3322F0CE378" modified="2025-10-08" version="1">MQMRLFALVSLMAVSSLAMDDIAPYWCSPVCQDFIALRNQCEDSRNCFEGGYNENTYSCLEPCWEIAAPCLQACRDNIYILLRTCDARCSTYGECMEDCFAEEFQAYKPELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VNZ0</accession>
    <name>A0ABM1VNZ0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methenyltetrahydrofolate cyclohydrolase</fullName>
            <ecNumber evidence="1">3.5.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC101861024</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.5.4.9" evidence="1"/>
    <dbReference type="RefSeq" id="XP_035824131.1">
        <property type="nucleotide sequence ID" value="XM_035968238.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824132.1">
        <property type="nucleotide sequence ID" value="XM_035968239.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824133.1">
        <property type="nucleotide sequence ID" value="XM_035968240.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861024"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF11">
        <property type="entry name" value="BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE_CYCLOHYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="7">
        <location>
            <begin position="52"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="8">
        <location>
            <begin position="185"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035824132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824133.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37861" checksum="BA7687D4976CF00A" modified="2025-10-08" version="1">MEHLRRGISMSMHRYFCCKHVKRVIIGTNQLRCFGWRRLCTSSRNHSAVIVDGLSIAQEIKNEIKTEVKSLLGSGKRAPHLTVLLVGNDPASVVYVKNKRKAAEYTGITCDILRLPSTAEEKDVVKQISFLNENSDVDGILVQLPLPEHISERNICDAVLPQKDVDGFNVLNVGRFCVDDTAFIPATPSGVLEIIKRLNITTFGKNAVVCGRSKNVGLPIAIHLNSDGKGASCEGDTTTTVCHRNTPPEKLKFFTQQADILVTATGVPGLITADMVKDGVVVIDIGITRITDDKGKAKLVGDVDFQGVSQKASYITPVPGGVGPVTVAMVIKNTLTAYKKEINFDRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPE8</accession>
    <name>A0ABM1VPE8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized membrane protein DDB_G0293934-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824290.1">
        <property type="nucleotide sequence ID" value="XM_035968397.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477278"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824290.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="25938" checksum="BDD219422CC981EC" modified="2025-10-08" version="1">MSSYALTVSPSHEHHHHHHPLHHFNSSNNNSSNNNNSNNNSSSGVGGGNVGVGGSGGVSNNYYYHHPHHQYYPHYFYQFPSNFDKLHPAYHHAGLIPGSDVSSDLTGSLVDGSELINSGNNHHSNNVNGKGSFSVSHLLDLKKNHGVLTAGSDNCNSSIGSVEDAQENGDESDQNIDQKGNIPCIIESNNNRNKSSSGGISGSNQKNGDSFVNSSNTRNSDNNNSSNSSNSSNSSSRGNGGGGGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPR4</accession>
    <name>A0ABM1VPR4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein BarH-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101861192</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824406.1">
        <property type="nucleotide sequence ID" value="XM_035968513.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861192"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF11">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="64"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824406.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25755" checksum="3C329C7D09C89851" modified="2025-10-08" version="1">MEYNLSYNNILLSLSPTVPACFPHIDPFLEQMADNSYSLPIPLPVYIRTRSPSGSESFVKPKKCRRSRTVFTELQLLGLEKRFEGQKYLSTPDRLDLAESLGLSQIQVKTWYQNRRMKWKKQVCIGGRGHLGYVSVVLQKGAKEAPTKPKGRPKKDSLDGGTESEIEVDDDTPEDDVTTEDNIIPLSPEVNSPTSEDELEAHDVEQTMAHEGAKCSDSEAEEREERPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSA6</accession>
    <name>A0ABM1VSA6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855837</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825298.1">
        <property type="nucleotide sequence ID" value="XM_035969405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855837"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825298.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47893" checksum="E268CDA59137F641" modified="2025-10-08" version="1">MSDPTNSEFKKRSARANSIEKRRLELEVSMFDKAKRTMAIDMRKAQSEYKHRLHLYRDRQKEIMMSRSSASPSTASMGEFLLQRLKSRRSASPLRKVVTPRGQSVEDINSWQKSLPKIQTTRRNSLKSLSDNSQDSSKGSEKGANCLSGPDSRSVKGRESPVDHVASAQRPPTRCCGNTNPPSEARRRSSTAPLRREASRPRTSSILKTRHLVSSLEGRPKTSGASVKILENSSSSSSQPANRCQSRKSLVLSDWDTSANQDATCDMDCVCLEDDSHSHDEFEAEEELGRISNRHRSKLDLRPSTAWSRLNGSTPELRQNSALESTQRNPFTGMTGHLGEPWRQVRYFDDDEIEERGLFYRLLLKDRLEREQTKFQDICAKVNAFCETPESPRETPRDTGSRRASKSQSTTLKQQTQQRSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSV1</accession>
    <name>A0ABM1VSV1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825493.1">
        <property type="nucleotide sequence ID" value="XM_035969600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477639"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825493.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48560" checksum="D31C25EA4D7B6545" modified="2025-10-08" version="1">MGLNRRPAIRDYWSQAETEHCAWYSQMFPRKRFEAIYHTMLHCSENSSAEGKDKIEPFVNSVLESFRRAFYPGKYLALDEMVVGWTGRWKYKQYNPSKPHKYHVKVFGLVDSETGYVVNLLIYFGRETSYRVDLDHSNPQAVKVFETLLDPLGPGHHVYSDRFYTSLDLIRHLSNNRTNFTGTLNLNRRGFPTDLKTLRLQHTERSWYYAPEDEVLCVAWKDKKAKKPVVVVSTMCDTTVEERPTSRGRNASKPAPVHSYNARMNGCDKVDQNVGYYNLHTRKSLKWWKKIFHWLMELVQVNALVLYNQTHAKKSTLAAFKRVLVKELVALAAAHMPQGEVDKAPSNMPPTNSLIDRYTGTKHLIAYSQKDRNCEVCSKPKEGRKRTNFFCKGCAHHPHLHPKGCFELYHTPESQRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUI3</accession>
    <name>A0ABM1VUI3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Exosome component 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101855647</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826075.1">
        <property type="nucleotide sequence ID" value="XM_035970182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855647"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="32"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="189"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035826075.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="45800" checksum="25BC4EC0DA2B9996" modified="2025-10-08" version="1">MRETPLSNCEKEFILNNIKEHRRLDGRNAYDYRDIRISFGVSLGCCHVEMGKTKVLAQVSCEVGQPKQTRPHDGVLFVNVELSPMASPAFEQGRPSEESVELSRLMERCLKESRCVDLESLCIVSGEKVWHVRVDIHVLNHEGNILDCSSIAAISALAHFKRPDVSVQGEEITIHPLEEKDPVGLSIHHMPLLVSFSFFLQGKYLLVDPSEKEEKVMDGKMVIGMNKHREICTLQVTGQNLLLKDQVLRCSSIAVTKVTKTTELIVQALENDKQARLRGEKHGFAEQISSEKVTSNHWRETQVKVKEEVMSASGGSGAESEDVDSDMEAGSGDSQTDAARLKDVEPNVDIVARGVGAIGEGGASRWLDLPKTTQTSKNKGKLKRSHPEETEVKQEYDEDSEEETQTVLNGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVI6</accession>
    <name>A0ABM1VVI6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein 64</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826428.1">
        <property type="nucleotide sequence ID" value="XM_035970535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862426"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF2">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="399"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="852"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="633"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826428.1"/>
        </source>
    </evidence>
    <sequence length="1104" mass="124145" checksum="6A74E5D045F2A294" modified="2025-10-08" version="1">MVAKRKRMGEAAGDRKRRDSVQSLRYISSLDSYISCSQKGAISLWTGQLRLQSCIDINEPAWVTGCDYLPGMRRVACCTERSIAIWDSRAKGKNQSIFIIKPIEHSPQCMVSIPNSNGGPEDKILYGDDQGYVNLLTILAKDLTMKNSKGDNKRSQNSQSYVIEPSKLSHHIIRKKLHDDWVLKVKYFPDLRCFASCSPSSNLSFCLEEVDKIFHLNEESRAVAIPKGVNCFDFCARANIIATGGVDKVIRVWHPHIFSRPTGKLMGHLFTIIDIAMNERDQHIISLSTARVFRVWDIHTLTCLQVFTDNEERPGEKRIYSMIFDNKHERLLTGSSVIDTWPLTRAVQDTMQVPHTHDRPVAQILYNKELNQVVSACTESVIKVWEMDSGKLVYSIPEAHGPNMEVTILALDKTGYRLVSGAFDGSLKVWDFGAGQLIKAKLNPSGSMEEDLSVTGLVCNKSGDDYYIIAAGWNNKLRMYLDSHDNNDLVLLRDFSDFFVLLRERSSLAGTSSPKSQSSLSARDPFPPTDPLPDIGQPKAQVTRLTEKECQLLLDHELTCMTVVTPDLIATGCNNGNIIFWSIEKSRVDKVYILPKEVGNKAKTGTDRKVNEIKLLVHKVRKLDPAYFKKMTRHRKSDIESISGKSNMSKKSRSSLSDKPLDPQIHEEASKQLEELAAKVEGEEGSQDEQKEKTEEGMDEVDSGEGKGDGDETDIDRVAESNQPEAKQEGSSTVDESVPTKTEDEEEGEGEEAPADVNSSSHMIVETFEPIIVSLHQDSFARFWDMDGVILREISPLTRRQGIPVTSLCHDEDVNILVIGDNKGYLTLWDVKQFLEDPETEDSNCLKQQVCWRAHMSKIVSLVYVDAQKAILSSSMDGSVRLWWGMKGRFVGFFGQHRPFNFPSSEDTGHAAVLPYDISEGPLAPVKRKSASHKIRSVQRFEYPLMFDKERWEPFRRSAYMSKRDQVLRPEDKKFFGALIKPKAYNSHLESFTTAEKNTGAVFRALPVYRVVTPKKPKTPDISFKISDDDDDNMYGKHHGGGHSKYSPTKLHPGQRQKPGTTSRNANSSLRGGNPLSRTSLLSPFPRAQQTTRLSHVSSFSIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWN9</accession>
    <name>A0ABM1VWN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">NUAK family SNF1-like kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118478045</name>
        <name evidence="5" type="synonym">LOC101849224</name>
        <name evidence="7" type="synonym">LOC101850182</name>
        <name evidence="6" type="synonym">LOC106011728</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102901.1">
        <property type="nucleotide sequence ID" value="XM_005102844.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937794.1">
        <property type="nucleotide sequence ID" value="XM_013082340.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012940542.1">
        <property type="nucleotide sequence ID" value="XM_013085088.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826831.1">
        <property type="nucleotide sequence ID" value="XM_035970938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849224"/>
    <dbReference type="GeneID" id="101850182"/>
    <dbReference type="GeneID" id="106011728"/>
    <dbReference type="GeneID" id="118478045"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005102901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012937794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012940542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826831.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30454" checksum="5DEAFC3EEE92F153" modified="2025-10-08" version="1">MRQVRVLCQKTITPVQVLEAAMEDDNSIRKAIKKIRLTDCQGRDSWLEIFHEISFMDYASHPHIMKMDWAVKCKDFVAICMPLCSRGSLHDARHRLNREQLERCFVQTACALRYLHNRWAVHGDVKPANVFLDESNNAILGDLGMSRLLAHGQNRVSSKNVLGTKGYLAPEIQSDITVDPFLTDAYALGATLWFLVFKRKPRDGEDLLHAVKSDRTLMPLLGFFRFVLYRLVQNNPRLRLSVCHLLEFLRERFQQFRVIIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXM2</accession>
    <name>A0ABM1VXM2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen alpha-6(VI) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827165.1">
        <property type="nucleotide sequence ID" value="XM_035971272.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846899"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046411658" evidence="1">
        <location>
            <begin position="23"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="30"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="221"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="502"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827165.1"/>
        </source>
    </evidence>
    <sequence length="730" mass="80217" checksum="C5D4C7552278F392" modified="2025-10-08" version="1">MKTLGVASLAILLSLFSQHGGAEQCRVKMDLLFIMDASGSIEAVDFPKELNFAARIAESFAVGPDLAQFGALLFSSRVKKLFCFDTHGTNQEVEDALRATKFTGGQTRTAMALSYARTQVFRAGKCGHRDDVPKVIILITDGKSRSTRRTIRQAKYLKNTGTTIITIGVGPLISMPELRAVASREDLVFSVTDFNALTYLREEVSAKGCQEGEDTCKVPVDLAFLLDSSRSLTKEDYNDQIDFVMNMTHEFMVSPTQTRVSVVQYAHRSYRQFCFNQHMTNDAVIEGIAARERRLRGSTKTYLALKYLRNRIFTPVCGSREGSSKIAILVTDGKANNPERALLEAEELKSTGVQLVTIGIGDKVDYDALKAMASSPSVAFESPEYTLLEAIKPNVSDTACDVAISAEIPTYEEECNSRCKYNLICVGEPMTCQCDQGFQFDSEAPGCVPYPGYQEECEDQCTSNLVCEDRIDVNMCSCPEGFEYDAQQSKCVESETCHAQLDVAFLLDASSSIGGNNFKKMTDFAAKIASHFELGPNAIQFSAVVYADVPKAAFCLSEYHTQPELEQVTGGSQMLKSADCKKLGVPSDGEPCTGACAANLVCQNDVCACESGYSFDNVTQECIMGYGDFCNGECKNNLECIAQAEEHVCLCKVDMFYESTEGTCKPDPGYQEPCKDRCVGNLECDDDTKVCNCEDGWYFNPRLDTCVEKSFIIGPKDTLMSVITYNRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W039</accession>
    <name>A0ABM1W039_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101863610</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828032.1">
        <property type="nucleotide sequence ID" value="XM_035972139.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863610"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1691"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2023"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2194"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2036"/>
            <end position="2053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828032.1"/>
        </source>
    </evidence>
    <sequence length="2385" mass="270459" checksum="F6CEF33D67501339" modified="2025-10-08" version="1">MYSGSNSDMEKKYEDHIISNELFLSEGVSNRNAPDNITGWEESRSSMYCPLKSVSFPRADREGKAEEYINVLEEEADDEDDDDEESSEEEEEDEDKQIWVESSVDTGEMLISVRGKGNRLETMTSSVDGAIDSADALKSDWNKARHTQTWQTNRIMKSLKGRVISSVREGLLSDRDLPPRPLPTPSHLQVVDERGLQAPPRKVASEWNALENSSFDQAIRGGLDGGRRQRFLELVQLPSRADRSKGLSSKRQLHRPEKTSDLERRFGRFETASDIRRRQSERSRTTKKSADLGSKESGRWLDKRKLKPRRERCEKIIEITDRCGVSYQVICKPFCLASANEAEELAKWQRKKLKKTQEKPPKKRLEKKLRGKQEKKLKKKQGKKLRKKQGKKLKKMQEKPPKKRLEKKLRGKQEKKKEAEEKARKEAEEKAKKEAEKKARKAAEEKARKEAEEKARREAEEKAKKEAEEKAKKEAEEKARKEAEEKARKAAEEKAKREAEEKAKKEAEEKARRAAEEKARKEAEEKARKEAEEKARKEAEEKARKEAEEKARKEAEEKARKEAEEKARKEAEEKARKEAEEKARKEAEEKAKKEAEEKARKEAEEKARKEAEEKARKEAEEKARKEAEEKARKEAAERARKEAEEKALKAAEDNARKAAEAKARREARAAAFRATVARIKDLTKSGASNVAMAVLDQLELIKRNNEKYKFPQRRGLYVPPQAYPIWLHREDKAKLLRLLHAITHPFPERKESEEEDVEEEEEEEVEEEEEEEEVIPEKSSSESTLLSDTMPNQESGGALKTILRALARRFTMTEVPLSQILKEQQEMEDEDMSIVSGDSQEGDNSAVIPVEPTERSERSGNVFVINENDLLSTAAPKTDALGVQQVNQASLQELPSIWDDIETDGMSEAGSDSAETVIEVGQDESQPLVARPWSSTVAFQEQGIDRIMSEDLSQNVPMLNEEDFKTQQRSQTDVFEEHSQEETQNIPVVVQGAVLEGVIDKSGKEKPTVEAERLSLIESESLEHKTKPHPAIVNDGKESSVDPDTLLSHASKREASDSFTRKSGDKDPESSSAGEVANKDSTPQRAVTDTGSYDANHPGSMPRKSSSREEDIAHVPGREKSDDVTDTAGSQKRQIPPNLEKEGGETGRFDESKSRGDAEGDLVRDNEEMKRVLKTASTTNAPDGEGDRATYYDETTRDISSTGLKAEEYNTATREGVGKETSKDIMKETSKDIMKETSKDKVKEMSKGNMKEKDNLGKTSKTSIEETSKDNMEGTLKEYFAGTSTGTIQEAKINSADALKLIEQPGRDTVKGHHGQHEENVLLASIGKEQQKRVAVETQYTEGVKTAGSSQDQSRLPPDDHLTTEETDESSHLASYFLDGNVEDGTPNKSTATNEESKAKGGPALVYGLDTDVERIKNEGKERGRKTDQEKTGNRTVLQEGTSSFQRTAEVQGRFGTYKKTPKSELLLALEKKSRKGKSQTLEITEDEGVGARDSLIQQMISRIEQVPKSKKGESTSKDGGLQINNLQTQKANQTGLNAQTLAAQGDGLRVPHMVSPGRGKKQLFQGSITIDKLMKVQPFSKQHKTTQVRNPDSAVFLSEMEECKKDNSHMEEYLAIRKKLQPKITLDCILKPYKNEKSCFAKYGKSNQGEVLLPCKPNNYEAAWCRLQKQRRSRYRPNRIKLDRLLSQNEKNDMKDPCNPQKSKFAKHANPSLPSAKVEEESMRIIKSWKACKRKQEEPIIDCWTLTGLSPRQFYLDSLPLYESEKYQKPHEDSVIAKFKEQLSVDADKPCDIASLCPKLSLNIDEILKQKPQKKSQFLYGKCNAEDWETIKNVRKRCSVGDKREPHTLLLSKVCSDNKNLDDMQEFIDRTKPKLKLNLDDILQGEIISSNQAAERKKTEEETLNRVYEMFLKPRENNKTCLEAEDHTTGAEQKKLDTTNHNRCDYLGNGRNQRIQDTNQTLLSFLDKLKPELSLNIDDILAHTGAIDASEKEKDKTLRTCYRYLQPHIAKETKVQRKKKKALTTEKVGQKSSLKIHDKLLQKEGKKSDQNAHRKPSSTCWSREQETRTFDANEVMSTVEVNNTLEKLKPKQYLHIDDILRQQETHTYTLDILRQRETHTLDTNEVMSTVEVNNTLEKLKPKQSLQIDDILSQKKIENKSKRKSSNVYGTRCYNAQSPFSERNSWTISHEKNKCTHRNPKNASSLNMSDVRERKERNKLHKVDKICDTNCGTKQLHSLNEALVLNSQTLSPETKVTTPVKSDNASKLNSNVEIMSLKSTYNTKRCQSVGAVTREHSNITWSSDLFADDRLDGEFRCHSSPKPHYVRDSGARCKVDIHKGLWHKGEESGGFRGEKMTIEDAKSFIEKIKPKVGINIDDILGGLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W055</accession>
    <name>A0ABM1W055_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Transient receptor potential cation channel subfamily M member-like 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101858128</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828048.1">
        <property type="nucleotide sequence ID" value="XM_035972155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858128"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03670">
        <property type="entry name" value="NUDIX_ADPRase_Nudt9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25969">
        <property type="entry name" value="NUDT9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="883"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="912"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="954"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="985"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1022"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1103"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="16">
        <location>
            <begin position="156"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="17">
        <location>
            <begin position="493"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="891"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1306"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1316"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035828048.1"/>
        </source>
    </evidence>
    <sequence length="1632" mass="185349" checksum="8FD716B92E5B3A62" modified="2025-10-08" version="1">MPKAWYRGITRKDDGFDEDREVNILNMPRVAPNERPLGSTVSLGQTSMQSLKFDDKAINIEEQGAFVDYSLTNQEVRFMKKVKRRECKSFIEKTNQDPSLDEPVCQCDYPKSRHSEEAINAGQAGGKWMPGLHTKSLPTNAFGEIEFVGYGDKVGKYVRVDVDTPMDTMLSLLTEAWGMEKPNLLISVTGGAKNFTMKARLREVFRRGLMKAALSTGAWIVTGGTNTGVMKHVGEAVRDFGLTSEGRVMTIGIAPWGCVQNKEHLITNDNQGKWPALYRIEKDVKKRQSFLDPNHTHFILVDNGTQMQFTVEIPFRAKLEEAIAAQKTDTGTDAVAVPVCLLVLEGGPGTLQTVHSSLMSATPTVVIKGSGKTADILAYAYQNAREEEVIGLDQQGNEVKGTNTILDPHVLAEITEMVQTTFGEASLATRVQWVRECCRNLDLLSVFELDSKNSARDVDLAILKALLKANKHQVMDQLKLALAWNRIDVAKSEIFTDERRWPTGMLDEVMMSAIQLNRVDFVELFLDNGVSLKDFLSIKRLIMLYNEIPRNSLLYTLLTRVKGKMDGGEERQLISIADVGHLIQELLGDFYQPHYLTDQRLRDIDTDALFGLTSKKTGIKRGITMAQLVTSSAATGSYIDPSQGSDNIDFSRPAQELFIWAVLMNHRRLSKVFWREGKEATAAALFASSICKSMRRYTFDAELGRQLEATSEDYAQLAVGVINTCYGMDERRTHELLIRDMPHWGCSTCVLLAAQSDNKPFISQTACQSLLNSIWMGKIAHDNSLLWIISSILLFPLVQFGIRFKEDDQPKQVEIQGTSLSEENGNTTSKEKPRLARRDTNIKPALSREPTTFQLDVQASESTPPKKGYSILDKHFMFYRSPVVRFSVNVIAYIVFLLLYAYILVVQLTREFHVVEGILIGWVFAIFVEEIRQLTSQYAHTVQSKIISYIHDRWNVLDVVTILLFILGMVFRFIENDDFMDAARVILSINFITFFFRVLHIFSVSKQLGPKVVMITRMVQDLLWFVVILLVFIVSYAIASEAVLYPNSELNWKLLFFLPRKAYWHVYGELLLEDIEGESSCTNDPALYNNYTELRCPSTVGRYFVPILMGCYILLTNVLLLNLLIAMFSYTFQSIQENTDMHWCFLRFNLVYEYTQRPALPPPFIIFSHVYIFWRYACCRRGQRIHPFDEFRKEFSSKLEEKQLIQWENVIADNYLSVTEKSEANSVSGRVKSSLERLETILAKVDELQESHGAVGQGPQGLPADGFSVQIPPMLQKRLDSVEKQLVLTTQALDWIMKSLQENNMATKTAKPLMPDLEKEKKEEEEKKKKKKEEKEKKLVQDLMEKKINSHYKSRLSPYLGSNVTRFSVPDEKVLWEIEFPDYDPPTYTSVEVLKQPAYADEDLLAMSPEVRKERYPFNQYDKKCRISRVSLYKPYDVVDGLPVNPIGRTGLRGRGALGRWGPNHAGDPIVTRWKMLDDGTCAMKDGKPVLQFVAVQRKDNSLWSIPGGICSPGEEPWNILKADFSEDVHGTLLDNPEAKREIMAQLDQLAALGHEVYNGYADDPRNTDNAWLETRVVNYHDAEGKILHHFNLRAGDEVELVTWQTIGSHSNLHGAHSFFLKLVADRHQAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0D0</accession>
    <name>A0ABM1W0D0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetylgalactosamine-6-sulfatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828123.1">
        <property type="nucleotide sequence ID" value="XM_035972230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852573"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF47">
        <property type="entry name" value="N-ACETYLGALACTOSAMINE-6-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045862374" evidence="3">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828123.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="54649" checksum="A4DB335F761E01F2" modified="2025-10-08" version="1">MFSVRFALMFCALSYFPLAARSDIARSSTQQSPKSAGKPNFIVMLMDDMGWGDLGVYGEPNKETPNLDKMASEGMLFPDFYSACPLCSPSRAALLSGRLPIRNGFYSDNAFGCNGMCIEYTHLGQQPRYHPLRHGFDEWFGSSNCHLGPFNNRDTPNVPVFRDADMVGRYYEDFPFNKQTGEANLTQIYINEATSFIEKQVATGQPFFLYWAVDATHDPVYASPDFLGTSRRGIYGDAVRELDSGVGRILQTLQKLKVDNNTFVFFSSDNGAATYNKAKGGSNGPFLCGKETTFEGGMREPAVAWWPGVVQGGQVSFQLGSLMDLFSTLLDFADIPAPSDRTIDGISLRPALLSNIVTDRSPIFLYRGDLLMAARVGQYKAHFWTWTNSWSEFHSGTDFCPGQEVKGVTTHKQTNQTASPLLFDLGCDPQEKYVIPPSSPIYQQQMPAILKAVKEHLATLKPGDPQLNWCDPAVMLMLKLKGSRDDSDKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W145</accession>
    <name>A0ABM1W145_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828388.1">
        <property type="nucleotide sequence ID" value="XM_035972495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860283"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF13">
        <property type="entry name" value="PROTEIN ODD-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035828388.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56672" checksum="B5E3EC899E7391D3" modified="2025-10-08" version="1">MMTFPTNHVTSHPGRAGLGPLPVPALLPYPLYLHSLSSAKLEPDVDIPQRHHKQHQQQQHQHQQQQQQQQHHQQQQQQAHHLHPAIHNGSFHSTPQKSNWELHFHKQLQHHYHQQQQQHLQLLHRYQRQVLVEKTEILHHPPPLSKHHHEKTPLYSSLAVIPRSETKDATISRQDIGKSRNSPSHCEKSVFIVSQSVAFLDTPQNTDEEILSDSSKDIKEKTVCHKKLGSVKQERIEDDLNKSLDSHCELSPKQLNRSCDVMSPLSVRGDASPENVLETTRLRLKEDLMDKPSDVKKARFDFANLPRSVSLENEGKGQSSDHCVKVISHVIPHLHPSSTTSLLPTTVHILPNNSNSKVRRQQRSSHARVKKQFICRFCAREFTKSYNLLIHERTHTDERPFSCEACGKAFRRQDHLRDHRYIHSKEKPFKCGECGKGFCQARTLTVHKAMHLQAATRSPQRRRLKEKTGREDNKTTVRGHASSAAGVKREPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1H5</accession>
    <name>A0ABM1W1H5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC101845042</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101845042</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828517.1">
        <property type="nucleotide sequence ID" value="XM_035972624.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828518.1">
        <property type="nucleotide sequence ID" value="XM_035972625.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828519.1">
        <property type="nucleotide sequence ID" value="XM_035972626.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845042"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045023442" evidence="1">
        <location>
            <begin position="25"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828519.1"/>
        </source>
    </evidence>
    <sequence length="562" mass="63188" checksum="305640D2171A2477" modified="2025-10-08" version="1">MGSYGLVVVALLFLTEFDKLLVGAEPFNIVADSGNSLKFQQENTQGDQISQKLMRESHVSEKQGSCDCDNDVSLKWESGSCKSVPSNDIPLHVNGIFPSITATASSGPKRSECGTGALMPWADKLYMVSYLSVPEGGNGTGLYEIDENFKMTKLREHNATFANRLLHRQTNQIIIGAWAIDMQGNINTFSGLLKVRVAATAEHLTSAATSVYMLGMDGPLWECNVVTYSCKQLFDLVKELKIPASVGEQPHFKAAHTMNGRLVVTSNTFEEADYIGLYHGGRLAEWKGPGSNWTILEETAFVEVTGRRNFGRVMYALGWDYRSVILKVFDGRNPDYNYWQTYRLPKASHAYDHLWQTEWPRIREVETERYLMDMHGMFYELSPLGWAGSTWGLRPISQHLRMIPDFTSFRGFLVLGGNQVSSIFDNNVVTGQAQSGLWFGKTDDLWSFGKPQGWGAVWRSDLVFNKNISDPYLMTGFDKKVVHVMTHDSCDQAAFTIQVDVSGAAGHRSLDDWASVYRMSLTRGSTYQFYVFPEGFSAHWVRLLFSTDQLEPCTVTAYFHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1M7</accession>
    <name>A0ABM1W1M7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein turtle homolog B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118478655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828570.1">
        <property type="nucleotide sequence ID" value="XM_035972677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478655"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="49"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828570.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18047" checksum="C24923995363129B" modified="2025-10-08" version="1">MCVSPSINKKGSLVITTAVKGDKGWYTCKPSNGLGHAEASAYLDVVYKPVVLPMPSPVTWALGYVQKIDCPVDANPPMTGVIWVKDQNLIASTSRFDILHNGTLRVSNVQASDAGSYMCTPSNSLGQGLSSSRVRVLVKDKPDPPTFSTLPEPEYIQQPGDTVVMPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1Z5</accession>
    <name>A0ABM1W1Z5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101861771</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828688.1">
        <property type="nucleotide sequence ID" value="XM_035972795.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861771"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF25">
        <property type="entry name" value="DUF4190 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035828688.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29066" checksum="F61D4719FC428BAF" modified="2025-10-08" version="1">MSKEDSFGFTHLVEEDDDDEAAPIGNGNLQVDLQPHLGGPPSYDTATRVTPSDHGGFDNPALQIDDGDCGLSERTLGPNVSRPRGSSQTQQTADPSASNGQSNPTHSTAAANTNNNEGSVNLSSIQVQYDSSQGKVNVMQSQVSTRPDGTRYIDTQGIPQRWSELQRPLRQRRIKYLKIFSIISCIFFFPSGIPAIYYAFRTEREFNEGIMRGNIDRAQKFAKRSESLIILSLVMSVVVAALVVAIIERPYFSHRDHAHKGAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3A6</accession>
    <name>A0ABM1W3A6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ectopic P granules protein 5 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPG5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829149.1">
        <property type="nucleotide sequence ID" value="XM_035973256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853594"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058750">
        <property type="entry name" value="TPR_Epg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059030">
        <property type="entry name" value="TPR_Epg5_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26103">
        <property type="entry name" value="TPR_Epg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26573">
        <property type="entry name" value="TPR_Epg5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26106">
        <property type="entry name" value="TPR_Epg5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epg5-like TPR" evidence="5">
        <location>
            <begin position="1433"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="domain" description="Epg5-like central TPR repeats" evidence="4">
        <location>
            <begin position="1928"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1551"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829149.1"/>
        </source>
    </evidence>
    <sequence length="2801" mass="315964" checksum="BC8AB6164E0C98CA" modified="2025-10-08" version="1">MIKTTKMAEAVRPRPRKQKSKKTKQASAKSEVNEEAEDNVCIQDAVKAPVEEQTPKDDPEQTAPDPVPTEKEEIPTGDGAIEEGTIHQKEKNEEKQTATEFESEDVAEESGTYSDARELLSGDYSGGQEDCVTEEQAGHEARPDQSINEKDTKEGQAFVEEKVVCENESTSAVPDGSSHVVPERPHTLLPQADEARSSPALSHVSDQERGPSLQHHEPTSVHSPPSAASLAAHMQRHHTSSLADNHRYRVGSPNSPLHIDGPAVVEDPDTPMMRATSPQIHKTLQRESTKSPPPTVPTVVYEEKSPTLMAEEALARMRAMDLQLRVEPSHEELASPVTDVLPGNSSVSFTAASHDTASKSSQSSEIWKKPGEKILSTQQQEIAATPAELMQTQNKSVSEEKTAVNIAEQPKVSTKSAFPVQELEKEKQKKGKLGAMTLEELLALYYNPQLAYNARFIDDFVQRESKKDSHEFLEILSNYFRTRHQLVSVEEDIHSLQKNYSGLQKELWQFQMKTITVQGQCADQAKVTINHSYEQCLLNDEAVNKMGYTLETIRSQITDNLSLFAYSAQISALQVESYIHDLYVSCPIIRDIPKNAPIQSRLQVLPQEEHQIQRLKDCISILFMFHRKPTLDGEFINNIRQWTVRLTSSLLRVATFSDHLFILNHLLRCPSGVGRWAAELVQLPVLTPVSSAPHQQTFGGPLLDHTITALATVLLPAKAREEFMCHMRINLSAESIQDERAWILVDSDGEEDEDPANTWLYLHENDIVALLNQFPLADLYAHIMMAGISESGSVDYDIRRSTEPMMIRLFAFSTVLIQLFGSGLTTYNMARYRQLNKRLGRLIRQTVCFVSDHWLNFKIYYGPLAPVASMETLQLEFDQLFMRATYSILTAQNGLYDFRLGSWQFMADMPYTCVSTDSMWQLLWVLHQGQGQVVNLDRLPPVQKCKEYLEDPDSWQQLADNLLHMPTSEAIYLLTTFANMASCRSYEEEAFIQTITLEVFEIAYICNHTREFCSKVGRELLSGIIQTHPTALSFLLARVKDVLAKLGKMSLYLFSELPVSIWQPSDPDILILRQWLLNFDLLSSENQLARVILGKINWDVFEQTGRLVVDVRLHRQMALLLVEAYTRFIADKKAGFFIMEGMRQMAFYMSSSLTAEQSFNNWVWDLAIRLKLHQHSVLLHAMGVVDLNFQPPNLGGDAWLLPVLKGTSNKTPIACFVALTMTNIGHDITSFISEGLDLLAVLTANYQYTTAIHVIGCVFPMFIDCPQYLLENINFIQIIQSLLGADESLLKSTKSTIMSVEFPGLVTQQLTEMIQALITSHLTHRKGDKVIMFWVNVIFKVCKFFTDRNSCYVADTLIQWCFVKKGVNDVMAMIFRENYLKFCYAFKNRQGALSSMWNWIASSTTLPSYMDSASLPEFPWLAYMILMVEGESEVNSRLWQMLIMELHSPNRPNIDNGLRVAVSKLHLEQAPTASRLTIYRWAQQALDTPFDHPLLPILWQRFFALYLGRQVFESCSIAQRASVGERFFESMSYSHMLKKMRKRLIDTSNFHMNFDPQKDGSHKRRRSSHSPTTPPIVDPSLDFGPGTARVNQEAEEITEYASSVEFHRMLAKLFQTYSLWLEEPRLHDGNLYLPALPPQYEAVRLNQVFQGFMGPWIEFVDLDGVQYTLSCLAADWRKRLTCSKTALYTAAAERRNTMIEQGDATERITRRLRRYDTPKPAPAIQNVASPVPEISTAILEDKEALNHLLVSDLQVLTHFTKVFAVRCAQHCALDNVYLELIPNLWANLTKTVQLNAPCKSKVNPLHRCTGPAVLPVKIESKEMNEMMNRRIEENRAEYKQVMIESLLPTAPHICVAAVHTENAITMLIKMSQRSSDTSRVKRLHNIACDLFFRLADMVCDEVNFYPPTKQFFASCMEILGQEFVSRDAAQTEAVLQLCLENPKVSGLVSPHFVPNSCPAQLVTMYGQLLHVLQAQNMELVFMLLTKFDIRQWLESHNPREAERKMLVESLGAAMMACGAEPEANSKLVFGLYLAHLAALLESRFPSNLCLVVNMVLQGSAAERLHTQVWETLLRCCFTDRVVHTADDAETRQRTDSVFDAAKVEACVDSPMSTVQVKELLDWLGAFFSHAKMSGGSENFGLYSHWSRYVPYLGLMIGALAQSFITKVVNGSEEMQPFQVLELVWQPVISVYSPWLQPLVTPDGQMTAPWLEGDSTQAVIMVASLKKSVLHLYQLMHAKHPTSSGGVLSLLLMYYMTALSTKVTPAHVSDVYVNELKELPWKCLWPDLQLLETMTKLKEVASTCCYALVGHILPQIKWREVMSHFSSQLHPDLASRMVASLAVLLVQSYVDPTFSEDENTCRLLTEAETFDWSLVRQDGFSCVCSWFLQLAEPKCALAQRSSNLALGLRVLKRMSGFLPDVPWTDQISTKRLSFIHCLTQQLCQVTYLSDVSTDAVGTAINNLMSDVEAVESSVPSPEIQAEESASLLKDVLSLLNNSNPDGPWLEVIMSSVTGWLRSSPHSILLVPCMKAASRCLASLSQMAAVMEAGIEVYFSGLDGTSPVSGSDPTGWSFILTVFQVPELNQAGYVQESLSENAFLVLYAYLQHRLPFCQRPEEELGLMEAILDWTCRALPSAEDESKLILWWHMMLFLTQRLVDAPWSSLTGVVNVLSRFSNHLNSLGQDRTSRGFFGVIGLGRKSSLSYKMRLLARALSAFLSCQLVTAEILRVYPTMKKGSNNTLQELRALKKNKTYAQCSSTIDHAVEFVQDPNHTIRDSLLFLATVVKDLYSDKQYLSVVWQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4Q9</accession>
    <name>A0ABM1W4Q9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetylcholinesterase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC118479136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829652.1">
        <property type="nucleotide sequence ID" value="XM_035973759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118479136"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF12">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829652.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="14963" checksum="5ADA2E4E2D23A0B5" modified="2025-10-08" version="1">WVHDNAELMGGDPSKITIFGESAGAVSVGYHLLSPRSMHLINNAIMMSGSPTVSWGVQDRVLAMDRSKKLARSVSCPTSSHAGMMDCLRSADPLELVTKQWDLISSFFDVPIGPVVDGTFLTDHPAELLARRQVEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4S3</accession>
    <name>A0ABM1W4S3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118479152</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118479152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829666.1">
        <property type="nucleotide sequence ID" value="XM_035973773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118479152"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035829666.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35019" checksum="E2A1218B6FA667C1" modified="2025-10-08" version="1">MSEPRSLSLLGMNAETMRSTGLNRITSVFVPFTTRALLSGPPLRASSMYTACGPIDDDLWEAGQETPATSQVFRYQSVVGHHAKPVCSELYIHRRDHRNGKKQVVPTMLYNLEANRPPVPEHQLLEDDFRAFRSVAHNRQTVLQSRMTPDLQVEKFLQDNHLACTILGTTPNSSELLQLAKLVRSPGCRGDQMVTYRNSVADPLGYVYRRHARHAGKQEQQGPRVAEKGVMATDAQRVLPTVQIDESFQNMHVPLCARNPNAEEREIHRFCADAILVSDFPERMYVHNEPDAVPSHLTQEDFSKPLIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2L1FDZ2</accession>
    <name>A0A2L1FDZ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cav2 calcium channel alpha2delta accessory subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="21">LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC101845552</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>The CaV2alpha1 EF-hand F helix tyrosine, a highly conserved locus for GPCR inhibition of CaV2 channels.</title>
            <authorList>
                <person name="Dunn T.W."/>
                <person name="Fan X."/>
                <person name="Sossin W.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KY705238">
        <property type="protein sequence ID" value="AVD53848.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826199.1">
        <property type="nucleotide sequence ID" value="XM_035970306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2L1FDZ2"/>
    <dbReference type="GeneID" id="101845552"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000007">
        <property type="entry name" value="Calcium voltage-gated channel auxiliary subunit alpha2delta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF67">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014682109" evidence="17">
        <location>
            <begin position="29"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="245"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AVD53848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035826199.1"/>
        </source>
    </evidence>
    <sequence length="1081" mass="122783" checksum="30B74EB4DFAB6E5B" modified="2018-04-25" version="1">MAAIRTSGVMSPSSILVIFLCFLQFSGGKETPDLKDVEDWAKEVDDKLWNFNYLVDVVRATYKEKSTDANPDPGIRMQYEKVNEEEMVQTMADSLAQMLKKKMDALKLSVEKAEEVAANYEWNKNLVKDNVHYVNAKEILSNGLELTYDERFGKGVNLNTSSVHIPVEIYDGNIDILNGLNWSAALEKQFELNYKADPEIQWQYFGSQTGFMRTYPATQWPGNGVDLYDVRRQSWYTQGSSSPKDMMILIDTSGSTHGQSLQLMQNAVKSILDTLGENDFVNIVSFAEKATFVSKCLNHTAFVQANYRNKKQLERDVDRLKALGQADFSEAIKFAFEKFIEFSQNETNDENNIGANCNKVIMLLTDGGTDNARDVFKKYNWDNNNKTVRVFTYAVGPTPNPITAVRWMACANRGYFSQIPAMGAIRARVQEYIPVLSRPQVIKNKKTFEWGNIYEDTLGLGMMTTVTLPVYNRSAGSSNQTILGVMGVDVTTAELESKSPFSKMGPNGYTFAINPNGYVVFHPNLKTGGTFMKEPPNVDIMELEVHREDKDDAINSLRNSMIEGNRGKKVITTLFLSPDQRYVTESQARYAFTPIENTTFRLGISVPLYQKMYPKFEGSIPALRWKNLESDFYSILVAPWNYYKNATHPEKQTMDDLQTWLSNDPNPDHWNLDLLYHLYWDTHILESGLITFLRNNMRSQKITYFIMTNGGMTVVSPKSEAKFFESMRDPRESSLYKRALHSPSCIYMADYSEAKRPNTSDSAQITMACGISIKKKISGQDLVIDKPVVVGARLSHDKLFDLVRDGMGKAGLDTTKLLSCDDVESLYCYLVDDGGFVVASNQDDAQQQIGRFLGQVDPTVMGKLLNEGYFLQTVQYDFQAACVKTDDTVSAGFKSFQIPSMTLLYEVLNVGWWTSKVSWAFVNFNLYSWLFSPSTQVWAEEDGEDEEKPCVEAMQQYYLEQRDPRPMTFGVQCQNCTRNYTVVKMRHTNLLFIVTDPMCEECTEEYPPLSQAPREVSEEEEESIICELAQNPRKRLQPFGCYHADPRENSKQCGCAALRVSYLSIFLVCLSVVRSYLSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA55</accession>
    <name>A0ABM0JA55_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Bifunctional coenzyme A synthase isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101852215</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005088948.1">
        <property type="nucleotide sequence ID" value="XM_005088891.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005088949.1">
        <property type="nucleotide sequence ID" value="XM_005088892.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852215"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02164">
        <property type="entry name" value="PPAT_CoAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001985">
        <property type="entry name" value="PRK00777.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="3">
        <location>
            <begin position="171"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005088948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005088949.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="60028" checksum="0E28CDB492DE5D46" modified="2025-10-08" version="1">MAKAGLLILTSPLSQLKSLLPRVIEEASVVVSDTLYVCLQPAVQNPTLSSFIQPVSSTQEVKQFISGLYLSGSNVCHTLDIRVLLSHLCKDPSIDIFKPYSVKKEITVWMTDSTKLKDLWQVENVAFIKALQNAFTNISFDSKFHFINVGQEAHSSSIESSELLKTFPNVVVGGTFDRLHNGHKSLLTECCMRCDNKLTVGITDGERNKKKTLWELMEPFSDRKAAMANFVSDVKPSISLEPVQIFDPFGPTITDPDFQCIVVSEETKAGGGMVNEERKKRNFKELEMVVIDLVDDACRADDEEEKVSSSSKRKRLLGTLIKPLPSRPNLSKSPYRIAVTGGIASGKSNVCSELEKLGAKVINCDLLGHKAYDEGTAAYQAIVKEFGQKVVDEDGKINRKQLGAIVFADRANLDKLNSIVWPAIRQLAEEAIAQHKAAGVPIVVLEAAVLFEAGWDDMVHEVWTAFIPRPEAVNRIKDRNQLSQEEAEQRIDSQISNEVRIAQSNVVICPLWAKEITRKQIQKAWSLLQKRISTPPVNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA75</accession>
    <name>A0ABM0JA75_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA (Adenine(37)-N6)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101849013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089019.1">
        <property type="nucleotide sequence ID" value="XM_005088962.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849013"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.10">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023368">
        <property type="entry name" value="UPF0066_cons_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818:SF0">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01318">
        <property type="entry name" value="TSAA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005089019.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="58351" checksum="06D4A5E2CE766A24" modified="2025-10-08" version="1">MNCTMKPIGYMKSLFHYKNGTPRQSSLCESARGILVIEKSVFTNPEHSLEGLEEYSHAWILFIFHKNNNPHSKAKVKPPRLNGRRVGVFASRSPYRPNNVGLSLVKIEKVEGSSVHVSGIDILDGTPVVDIKPYIPEYDAPKQREQNENCLNKFEPPDCSEEPMTVDSILPTVLETTLAPSESIVNAEKSLSSSSVFNEEIDSQSFHIGDNRQVICESQTQSDKCERASPDCRGDSEPESVRALTEGFYSMSAALEKAEHKLSGATRCDTSVGESVTDTLCALDSSLDAGRESEQDAEEEDISLLIGNIISQAALDLNNICPSPQASVHEASGPVSQSPCEKVLSGTETPSTEGGSKKSDKCSQDTTPVHSKSKSGKAKSCSRQYETTTTLSKGCDSVKSKEDNISTVVAPWLKKPPIPQLTVSFTTEALQQMQLFSPQSADPNFRLQMITGPEEARKSISEILQEDPRSVYRRTHCSDSLYFFAVDVLHVTCWFDKELSAQVVRVQPTAFASKLKTVERTFNHNSKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JB33</accession>
    <name>A0ABM0JB33_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089579.1">
        <property type="nucleotide sequence ID" value="XM_005089522.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849974"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF62">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005089579.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30833" checksum="1EF607ABF590763C" modified="2025-10-08" version="1">MLCCRKKKREREEKPAGRSEASDSRESVSSSSRWIMGNSNLKQHIETAQKTGACQLRHLSLKEVPEELQKLSKNLRTVDLSDNRIPHLPPWFVTFASLKNLTINNSRLASLPEDFGQLKKLEVVSLCSNSLTSIPRSFANLSHLKTLALSGNRLTAFPKELLNLQQLDSIDLSQNAITELPQDMSGLQATELNLNQNQVSLLPNTIAQCQRLKVLRLEENCLDISAFTPEIMKTSKISLFAVEGNMFGMKAFNQLDGYDEYMERYTATKKKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC83</accession>
    <name>A0ABM0JC83_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Organic cation transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090349.2">
        <property type="nucleotide sequence ID" value="XM_005090292.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861704"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="70"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005090349.2"/>
        </source>
    </evidence>
    <sequence length="596" mass="66382" checksum="0C4FAD0EE0AA4BF1" modified="2025-10-08" version="1">MFSESSAEAEAELLSKDLTKGGVQTRDHVFTLADMPKYSADNSDDVVNSADEVDQLQQQLGGYGRYQILIYVLIGLVYMRGGWHVWIPGLQAYDPGYHCAATPGLHLNESVPGKMEKGVWEWDTCKQYTNYSVNNHTEPCTNGWVYLFEDPDTTSIVSDFDLVCDRDYLVTLTSTIYMVGTTCSVIFLTPLSDRFGTKRVMLVCLWLQAIVGTALVWSGNIIVYSVFKFFIGLFNMTIALCAYVLMTETFDAAHREPPTIFMQFFWAMGIMSLALFGYLLPDWGHLELVIALPINLLSFFYIWLIPDSLPWLLSKGRTGKAKDVILRFLRVNNLPDIPLLDKTLDKFRKQKDEFDIKNTGGQKAPVSADESQSITGENGGDGRLYTMLDLFKTPRMRINSLLMFYLFLVNALAYIGIMYTSPDLNGNRFLNLFLLGVVEVPAYITCFFANRFIGRRKTICGFLFVCGVANIAALLLPATAGDGSSLEWLQITLVMIGKFAVTGSYSTIYLYAAEVFPTVIRNQAIGASSFFENIGSVAAPSMVLVNDQVNHLPLGIFGGMTVVGAALVLLLPETHNRPLPHTIEEVEQNGANKAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCD5</accession>
    <name>A0ABM0JCD5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nicalin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101864275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nicastrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090447.1">
        <property type="nucleotide sequence ID" value="XM_005090390.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864275"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03882">
        <property type="entry name" value="M28_nicalin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016574">
        <property type="entry name" value="Nicalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31826">
        <property type="entry name" value="NICALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011018">
        <property type="entry name" value="Nicalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="216"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005090447.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="62483" checksum="79828A6C6738977B" modified="2025-10-08" version="1">MWFDEVGEIFELFKGSFPLSFLFFVPIFIIISPVSPVNAAQEFGVYRMQQYDLQGSTFGCKNSIINMEARSIDCKMLTRRCAVAKLQDVTMPKYRDLMTQNAGALLVILPQNLGNLSAEERQHLQSLEREIVQEPTSVPVYFALEQEYLKDIYLDVQEGTAGDNAATAWEALVSSATANGFQLVVSGTAAEALPDFEVANIQGRLSGYGIEEQLPTIVITAHYDSMGIAPSLSYGVDSNGSGVIILLELARLFSKLYTNSRTHAKYNLVFLLSGGGKFNYQGSKRWIEDNFEAAEGNMLSDVAFVLCLDTLGAGNELKLHVSKPPREDSAGGQFYKQLEEVGSSLYPEAKVDMVHKKINLADEMLAWEHERFSIKRMLAFTLSHLGSHKSPDRNTILDTRAAVDSGVITRNTQIVAEALARQIYNLTSQGSFEMFTDTLSVEEPVVQSWLDYLSSGPRAAQLLKSDSEMVMTLEQTMGRYLKDVRKTLIKADKRDPEFLFYSGSEYVMNAYNVKPAVFDLFLAICIASYLALAYLCAQNFHVIYYALKRSVIPVSPKAKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCM5</accession>
    <name>A0ABM0JCM5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101846182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090618.1">
        <property type="nucleotide sequence ID" value="XM_005090561.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846182"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005090618.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35384" checksum="452B52389D45BE10" modified="2025-10-08" version="1">MNQTFRTKSRHGYSVKFSPYLPQRIACATSQYYGIVGSGSIFVLDVDPSGVRVVQQFEWSEGVFDLTWAENNENILVAAGGDGSIQVWDVSQPQGPLKALREHTKEVNAVDWSQTRNEHFVLSASWDKLIKLWDISQAQSIETFQGHDHIVYQVSWSPHVPGCFASASGDHSVRVWDCRRSDGCVALIPAHEAEVLSCDWCKYDQNLLFSGSVDGLIKGWDIRKPAHPVCVLRGHKYAVRRIRASPFSGSIVASASYDFSVKIWDTEQELCLDTVEHHTEFVYGLDYNLHVPGQMADCAWDELVHVYQRPLNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEM8</accession>
    <name>A0ABM0JEM8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC101853293</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101853293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091996.1">
        <property type="nucleotide sequence ID" value="XM_005091939.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012946950.1">
        <property type="nucleotide sequence ID" value="XM_013091496.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853293"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021070" evidence="3">
        <location>
            <begin position="21"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005091996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012946950.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="57363" checksum="52813C27CC1E9460" modified="2025-10-08" version="1">MPSTGALMIFLFGYLVGAEQKNITLFVDKPERSCSRVVDLRDTRTQYSVFLETEDCIKCQKADVCTTLQYRECKVEFVAANSFLSATYKICYDKSPQNISDCSSRIKYEKQNVVSRNDVLELLWCENEYQMDSEKDGRNCLDVNDSLIIWYNSYNYCDVSGFTRVYLWKNHSDAFALHSQADCPNGQENVRGSSGRVISHVDASEEDRAAMCEITLIPDRLCRDYKQICFTFEHVDFPDGGASLFFLSDEIRKFNYDNKPYVDSEYCMVMWKSRVVRVAVEPSVNYSYVLEDRYLHAFSFNYYFKIREFSDTSVLSGKEDSDIENDTASRQALALFFLCVFTEVETLVLLVFRIFAIAIGYSVVMIFLIRRLEKDQRQKASRQGHTVATSGAATASGTSADNGLQCEDENISLVNRGDDDRTEGIPIQISGSPDGCDMAATASWSYVDSWPPCMAPPAYCDIPEKDPNSVVPGSGLPCQIVPSDEQPPPYTDVFPHVEPAASADSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF27</accession>
    <name>A0ABM0JF27_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trinucleotide repeat-containing gene 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092243.2">
        <property type="nucleotide sequence ID" value="XM_005092186.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850464"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092243.2"/>
        </source>
    </evidence>
    <sequence length="396" mass="42045" checksum="8EAF5274B66E35A2" modified="2025-10-08" version="1">MTSKLFLVTAHWRLHGQSQETRRLQWSVDDSNFLKFSVRLEQVFEGKFDKGNVSISYADPFGCHGFITMSSNSEFEIGLQSMSTDLEIFIDERCSPGIQLVEDNWSTVTTTTISSHCSSRDFAMSPRSGNELPTSCPDLERVFSTSTSLSPNPSSGGFSFNDGVAEKSQSETRTSARSKIVLEKDCTITASASISSSSFSSNSNPTSKDGATEAGSSSNNCAKCGKNNTNNSSTGSGGSYNGVSTNDKPCFCKSCYSKVNTWATSTANKTAKNNESALPRNDSTKDLAAKEDSRLQNPSPHNPDTEIAAAAQAAAAAASAETPPAVTAAAGPITGGVVSPRSPSSKSPPMYSKLPPGNPSRRTSASAQAENNQGISPEGLRRRLAFQQSKSKRQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG14</accession>
    <name>A0ABM0JG14_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101852455</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092854.1">
        <property type="nucleotide sequence ID" value="XM_005092797.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852455"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045115100" evidence="2">
        <location>
            <begin position="18"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="36"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092854.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="31294" checksum="E6B3FC6FC58A0D0D" modified="2025-10-08" version="1">MLFSWLTLLAVMASGSAITLNDCPAALPRDKYLQVHGDSCFRFVLTHYRYFFDAERDCEHEKGTLALVKTFEVQEYLAKELVNTYGVLKNTKVWIGLNDFAKENQFVWEDGTKLVPSAYSNWAPDNGPRDGLIQHNLEDCVSIDVTTHKWHDHHCTDFLFFIYEKPYVCEYKVSAPATSPATTTSTTSAPATSPATTSTTSAPATSPATTTSTTSARSSSPATTSTAFVPSSSPETTTITKSTPSSSTQSSQETTVCPPFNCHLDCGLDGYALDPDTGCFVCDCSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGC7</accession>
    <name>A0ABM0JGC7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101847410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093094.2">
        <property type="nucleotide sequence ID" value="XM_005093037.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847410"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="10">
        <location>
            <begin position="146"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093094.2"/>
        </source>
    </evidence>
    <sequence length="351" mass="40617" checksum="54A06889DD17C3DC" modified="2025-10-08" version="1">MNKMAAHMKILTRSTLLRAITKPAVVSPLAVGSQQHDVQQTRNYPTSKHYDLKWRQKRREKVLEIDLPKFVELKKDKKKENRTPDEIRMEMKKEGRLPPRFQQDLPINTSCTRSVIEPYKPKDGDGRQTEILTSGISDNVSRMVQGTKSLKHVRKLKKFEDFVESEFAEQAQNIVIETHDLLQDVYKNQERLHELVTEKAFPEMVHGMESKTMRWRFVESVEPPKVVQIRVEEMITQDNLFAQVTVRMHTKQILAIYDRFGRLMYGDPHLAKSVVEYVIMEKWISDTYGTWRIHGKVIPDGAPSRDALLRTYKVPVFEPLPPLEEKEGGEKKEEGEVDRMTGGGGLKPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH63</accession>
    <name>A0ABM0JH63_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101857175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The helicase domain is involved in the stimulation of RELA transcriptional activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005093572.1">
        <property type="nucleotide sequence ID" value="XM_005093515.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857175"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17938">
        <property type="entry name" value="DEADc_DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12873">
        <property type="entry name" value="SPRY_DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 10 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="11">
        <location>
            <begin position="70"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="273"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="498"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005093572.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="81325" checksum="89CD6C14ACB4580F" modified="2025-10-08" version="1">MTAFEEMGVMPEIGKAVEEMDWSLPTDVQSEAIPMILGGGDVLMAAETGSGKTGAFCLPILQTVHETLKDIREGKSSARKSKKGGGGSQWKMNMYDRGDAMAIDPDGLLCQARDAQGWHGTRASKAVCGKGKYYFEAIVTDEGLCRVGWSTAKAKLDLGTDKFSFGFGGTGKKSWDKQFDSYGEAFGMNDVIGCYLDLDKREIRWSKNGIDLGKAYDIPGHLSNEPFYPAVVLKNAEMRFSFGKTEFKFPPQGGYIAVCQASGDCCLDSKIVGQSTANAAPAPNAPQAIIIEPSRELAEQTLTQIQKFKKHLDNPDVRELLIIGGVNVKEQTDVLARGVDIVVGTPGRLEDLISTGKLALHQVRFFVLDECDGLLSAGYGDLINRLHQQIPKVTNDGKRLQMIVCSATLHSFDVKKMAERLMYFPTWIDLKGQDAVPETVHHCVCTVDPAVDTQWKQLRRQIKTDAVHEKDRINPESHSAETYSEAVKLLKGEYVINAIDEHKMDVALIFCRTKLDCDNLEKYLQQRGGGKYSCVCLHGDRKPHERKGNLEKFKRKEVRFMICTDVAARGIDINGLPFVINVTLPDEKQNYIHRIGRVGRAERMGLAISLVASCKEKVWYHSNCSNRGRGCYNTNLTDHGGCCIWYDEPKLLSDVEEHLDVTIDRIQPDMKVPINEFDGKVTYGKKRTGGGSAYKGHVEFLAPTVSELAQLEKKAQTTFIDLKFKKKLANRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHH9</accession>
    <name>A0ABM0JHH9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase-phosphatase E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101861345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093774.1">
        <property type="nucleotide sequence ID" value="XM_005093717.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861345"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01681">
        <property type="entry name" value="Salvage_MtnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00044">
        <property type="entry name" value="enolase-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005093774.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34403" checksum="096092714797F098" modified="2025-10-08" version="1">MMAPQKRSAEEAESLLVGVRSIVFDIEGTTTPISFVKDTLFPYVRNNIDGFLTKNFENAEVQKAITALRDLATKEKEEKVEGAVEIPGGDASKEDVVKAVSENVKWQMDGDRKTTELKALQGLIWKDAYESKEVKGELFEDVGPMLKMLAEEGVQLYVFSSGSVEAQKLLFANSSQGDLTDVFSGHFDTTTGSKTESASYKKIAAEIGNEPKDILFLTDIPEEAEAAVAGGLRSALVIRPGNADLTDEHLQNFACIERFDELYGDEDDEDDIKRFAGDNGEADDDDDDEDEGDEDDEEGEGDNDDDDENPDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI04</accession>
    <name>A0ABM0JI04_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005094077.1">
        <property type="nucleotide sequence ID" value="XM_005094020.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850942"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044963751" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="41"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005094077.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="62707" checksum="297D9DAEF2109740" modified="2025-10-08" version="1">MAAAWLLHALYTSMLGSSGLQGGQGGQGGGQVGRNDVYLMANTSYGTVRGKVDFTTQVPVAKFLGIPYAKSPTGKLRFKAPEAPDAWSGVKDAFQFGHTCMQMRYPLYTPSDMSEDCLFLNVYTPTTKTSPGAIPVMVWIHGGGYVTGSSSLYDGTLLAAKEVIVVTINYRLDVFGFLSTGDDVIPGNYGMMDQIAALQWVRKNIGAFGGDPNQVTIFGESAGSSSVSLLTISPLSKGLFQRAIMESGASLSPFGFQHPGNRISALTNARLIATGVMCGNLDDPKKLLSCLQNVDVQRLLNVSVAVSKALDVNLIMCPRVEKTFGFLPDLPGTLLSRGEFNHVDTIRGFNTDETGAFIRNLIKRPISPEVADDILHYWLKQMSSLAQEQAATILKSRYMKDELNVVNLQRDAMEAQDDFAFIGPTIIEANEFSRRAPEKSHYLYEFNYRPSYSMYPKWMSATHSDEIGYVFGVQQLVWIYGILPTKDDFSVSKQIMDLWTNFAKTGNPTPTVHAGSVQWNQYSATMPNYLLIKLNSQQKTWQRPEAADVFSQVLQKLDGTRQTPVDTIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJP1</accession>
    <name>A0ABM0JJP1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101854077</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095231.1">
        <property type="nucleotide sequence ID" value="XM_005095174.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854077"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095231.1"/>
        </source>
    </evidence>
    <sequence length="689" mass="76663" checksum="F82AB6C20DCF92C1" modified="2025-10-08" version="1">MYNRVRKPNYTQEETIALLEQLHIYKHLLFRRSGPGALSYSQRADIWANIAQVVNAVPNSAERTIEELKHRWKDMSHRARTALKYIREADASGKKILKPSVAYFDIIMGILGDDVPPHIKSALQPDFFSMPRTWENPVESYESVLFLRSDDTKEVKPDLSQINCSPISGGCMYVPKNVSTYFSRDRENSQSFSAANSSQPSLVHNIKTEPEWESNNKQKPVLSKIFNKVCAMNDSSSGVFTKKLLCETDMAAEQSSNGLQGVMAGGDRADAIPVPMSQVDRCPMVLDPNTEMVVHVNHSKDEEIMRSSASTPFREKSEPRKRRVSTPPRHSSTSPSKKQKVRDGTTYDPETADAEELKRCYYINKIEMVRQKREFIRLQEMKLHMELRLLQQQLFSSGLEPMAEQDSLVGHRSSEASSSFLGLSSRQQDCSPPLAGLHHPATTSGFTGPFSGQNDSRHGLRRSENLPFVNTNNIDGVEIVNDVDSYSVSSRGDFENDNVVDAGENDNEESDDDGCDNNIDARNDSGICHDNDTSVRDDNERDNNGGNDVNVLENGESRDGNDIDAVRELEQNECDNDNTVITSIDNGNGFVVTNQGSFNRTDDCFEGVGDINISGGVSGCRGDDRHSTNNSTENDERDCVQPVENHNAGNCGNYSKLEISSLPGSESNNVPSHTEDLTNEYSDLSSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMI6</accession>
    <name>A0ABM0JMI6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SR-related and CTD-associated factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097171.1">
        <property type="nucleotide sequence ID" value="XM_005097114.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850883"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16983">
        <property type="entry name" value="CID_SCAF8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF4">
        <property type="entry name" value="PROTEIN CBR-NRD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="487"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="596"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="835"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1249"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="841"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1273"/>
            <end position="1283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005097171.1"/>
        </source>
    </evidence>
    <sequence length="1351" mass="147729" checksum="40436693571DC057" modified="2025-10-08" version="1">MDAVRSFNNELSSLYESRPPVSRAKMAQVTKCAIKGIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGPEKDVFSPRFTKNIVNTFTFLFKCPAEERSRVVRVLNLWQKNSVFPMEVIQPLLDLAADPTNTELVAAAQRSVDAVVSMSQKVPLPNTHSSSNGGDSNQLVQQTEMLSTITKLLQQAQDGSMTASAPESQLQQLQHLQQQLVMQTERISKPQQEAAPAIDSNLLAQIQTLTNQLLSKTSGNADAAGDAGKSSKPAEPLFNKKLLDFDYGDSDEDDDHQHHHHHHQHPPPQQRPPPLMMTQPPPGMPPVMQDPGLLQQIQQMSQQTEELQSEIGAQEQLRRRLLEQQQQQFDREIGQAAFMGQPPPQNFMGHDDLRGLDEQEDDENRDGRDRGDRRRRRGSRDRSRSPRRRRRSRSRSRDRRRRSRSRDRHRRSRSRERDSSRRDREKERERRKKGLPDIKDQHISICTTTLWFGHLTKHTTEEELREHIEKYGTIKTINMIPPRGCAFVCLTRRKDAFKALDRLKGVKVNTNALKVAWAPGIGVKESMYKNLWDVEQGVTYIPWEQLPADITPFLDGGMVDEDTLPDRLRGINNGEDDGGDDQQQQQQQQPQPPQQLLQQQQQQQPPPQPDQSMDNEGMHGMESMMQQQQLQMGMPRQPPNFPPGGMPGQNAMNLLGPGGPLNMMGRPPMDMRHGGPMGPMGRLPGMGGPRPGMPGGPNMRPGGPMNLGGPQGGMLGQGNQLRGPGPRMDTPPPGMGMNSPNPRGAFPQMGAMSPRFPQMGGPGGMRPPFFNNNNNNNNDNNMSGMGDSDMRGGMVEPKEWPPDDEVNAEDEPDEDSLMDSDERMLPLNAGQRMPPGMNIRAPLGNPFGPRGPLNASGPMNAMLAGMSRAQAPSAAGMSAMLSLRMMPPGQQQQMLAMAGGPGPGFALAPGGVRLPVSAVGVRPGLMSAGAPTRLLPQSSGGPLPVAVSMNGSVVVSRPTVPVSSTQMNNASPDIPLPSSERPPSRDDDSPHSMLSRRSPNPLPLMQMAGNNRPSPGGPILGRGFAPMTIRPRGGPGLLGLRPGAQGGTFSRFGAPAHRPMMGGFGGMDRPAFGGRFGAPFRPPVGFMDHEDKDERRMLPRLDVDERSGDIDERSVPKSDEKDRDGPQKDVDERRDVDEREKVSHRSGRPSRWSDANDTVDVDVPEPVVPAAVEPVPMSESPGPDVVASPPRVASPVEAVVEPTPVVEVPQVVESPPPCNVPEVETHTSPPPAAPLSAPFDPPSAEFDPPSAEFDPPSAVIDQPPSAMEPPPASEVCEPVATDSGPGEGGPSEEALLPDATVESGEAEGEADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JML0</accession>
    <name>A0ABM0JML0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nudix hydrolase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101863665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097225.1">
        <property type="nucleotide sequence ID" value="XM_005097168.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863665"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04670">
        <property type="entry name" value="NUDIX_ASFGF2_Nudt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003293">
        <property type="entry name" value="Nudix_hydrolase6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040618">
        <property type="entry name" value="Pre-Nudix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994:SF13">
        <property type="entry name" value="FI03680P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994">
        <property type="entry name" value="NUDIX HYDROLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18290">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01356">
        <property type="entry name" value="GFGPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="97"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005097225.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34784" checksum="838BD804C01A9AD4" modified="2025-10-08" version="1">MADQIIYSLDRFSSVHVDTEKQQVRGQDFITSLRDALPTWRAKGHRGVWVTVQKELSACIPQLIELGFDYHHAEPGYAMLTIWLPETLPNNLPAYANHYLGVAGFVVNEKNQVLVVRERYHNTNLRSPWKLPGGHADRGEEISTTAEREVFEETGVKSEFVCVIAFRHLHNYRFGLSDFYFVCLMRSLSSEIKACPNEIAECEWMDLEDYENYEKISDVNRFFVQQYREIVASGNAITPHDVRSYDRISWNKVYSADRLVEQDRDGQPAVSSVVSSALPPSAASDSSTAEGNQVLQQEKGEEEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN39</accession>
    <name>A0ABM0JN39_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101859480</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aerolysin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097555.1">
        <property type="nucleotide sequence ID" value="XM_005097498.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859480"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20219">
        <property type="entry name" value="PFM_physalysin-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.412.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055267">
        <property type="entry name" value="Aerolysin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053280">
        <property type="entry name" value="Aerolysin-like_pore-former"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34007">
        <property type="entry name" value="AEROLYSIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34007:SF1">
        <property type="entry name" value="AEROLYSIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01117">
        <property type="entry name" value="Aerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00999">
        <property type="entry name" value="Aerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045546403" evidence="4">
        <location>
            <begin position="25"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Aerolysin-like C-terminal" evidence="5">
        <location>
            <begin position="192"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005097555.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="64395" checksum="18070FD52195D3FB" modified="2025-10-08" version="1">MAVDIRTSCCLLLLLVASSQAAWCRNEYWTGIFNKQGLAKCEDTKHAYMQGIHRLAKGSPDGISLIDQVGCCYGTIPYTYDFSQVYYADWTKSFDANNRWNSCPRGYFVQGLYRDKGTNTLQDIAEGRCIKPASHPYRYGECYDLSISPFFETEGWHRCNDHFFITGIYRGGCNELYCLKTLKCCKMAPQPQVVNSLSAAKVMVMDNTMSDLAKLADMLGYGWCAGCRAAFVGEDFRRDGDKWVADKREPCDGYKADHRLSMEYGDWKFAIKEMVFGDPIIQDLQPEAIDTGILTNDSPNTVTHELERGTEVTRTVTHTASSEWKHSEELGLTVGYAPPDATGGFSVESSFTFNYEKSSKTEDANGKEQKKSFSVKQSTKVPANSAVKWTMILSKTRRTVPYTAKVVVQFSAELQGFLRWGGGVNGDTTNFHNSYKGSGARPTFNYKFGSPKTPFYEALKEQSDTMQYPWLWADMEARYSNARELIESLSDEGRYEFFLNGKFDDISGKDVQIKWNDAGSARRRKRSADKGITQVVATEGANDPPEVFPPPPVVKKDPVVRVDTLNEMPIQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNB5</accession>
    <name>A0ABM0JNB5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xaa-Pro aminopeptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101856574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097713.2">
        <property type="nucleotide sequence ID" value="XM_005097656.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856574"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045901290" evidence="4">
        <location>
            <begin position="23"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Creatinase N-terminal" evidence="6">
        <location>
            <begin position="87"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="5">
        <location>
            <begin position="385"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="7">
        <location>
            <begin position="614"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005097713.2"/>
        </source>
    </evidence>
    <sequence length="708" mass="78758" checksum="3F0F9659B6FA2B14" modified="2025-10-08" version="1">MRSGLTACLGLLLAVHVCVVRPTTLQDRQNCGPGDTPPATRVDTTERLRIFRQNLNTIRTASGSVIAAFIVGSGDAHNSEYPTSFDRRRGFISGFGGSAGTAVITQNSAALWTDGRYFTEGEEVLDCNWILMKSGLPDTPSIAEWINSQMTSSGQVVAVDWTLVTHTYFTTMKELLAKMSNAPDLQYVTSNNNPTDRTWTTGRPEQANSPINALDIQFAGIPWSEKISDLRTKMTEEDVKAFAVTGLDEIAWLFNIRGTDVDYNPFVLGYAIVEQNTVSLYIRNKNSKLQAAPTDNSTSETLQRHLGTSALGSCAGISTPCVQVREYVQSDVENALRTIANTGRVWVTFEANYAIYSSVQNNVLVDKSPIALSKSMKNSVERMGMQKAYNRDSVVLIKFLAFLEKEIEAGREWTEVSAAEELDKRRSQAEYARGLSFETISSYGPNGAVIHYRPSETTNRAITTDGLYLLDSGGQYLDGTTDVTRTMHYGTPTDFEKECYTRVLMSSVSLAMLRWPEGLYGRQIDALARYQLWEAGLVYRHGTGHGIGAYLSVHEGPGRIRLKTTLNPSDEPLSPYNYFSDEPGYYEENKFGIRLETIVMVSPHTPKYDTAGVGFYEFKPITLVPFEPKLTDLSMLNTKQLQWLNKYNTMIKDDILPLLAGDQVAINWVNKRIQPIDLPTICGAEALTFYPLLAFVSTLLSLSFMHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNW9</accession>
    <name>A0ABM0JNW9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sperm-associated antigen 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101845323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098092.1">
        <property type="nucleotide sequence ID" value="XM_005098035.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845323"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314:SF0">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005098092.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="55047" checksum="73D6EC894429D9F7" modified="2025-10-08" version="1">MSRQVLQVFEQYQKSRTQFVQTVAELASRPQNIETLQNAGVMSLLRPLLLDIVPTIQQTAALALGRLANYNDDLAEAVVRGDILPQLVYSLAEQNRFYKKAAAFVLRAVAKHSPQLAQSVVDCGALDALVICLEEFDPGVKESAAWALGYIARHNAELAQAVVDAGAVPLLVLCIQEPEMSLKRIAASALSDICKHSPELAQTVVDAGAIAHLAQMILNPDAKLKRQVFSALSQIAKHSVDLAEMVVEAEIFPAVLTCLKDPDEYVKKNVATLIREIAKHTPELAQLIVNAGGVAAVVDYVGESKGNVRLPGIMMLGYVAAHSENLAMAVIVSKGVVQLAIALSEEHEDHIQAAAAWALGQIGRHTPEHAKAVAVANVLPKLLQCYLRADVSEDLQTKSKKALKNILQKCVHLPALEPLLHDAPPNILKHVVGQFSKVLPHDSKARRLFVTSGGLKKIQEIKAEPGSALAEYINTINNCYPEEIVKYYSPGYSDALLERVEQYAPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPJ0</accession>
    <name>A0ABM0JPJ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Apolipoprotein D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098523.1">
        <property type="nucleotide sequence ID" value="XM_005098466.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847585"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19437">
        <property type="entry name" value="lipocalin_apoD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003057">
        <property type="entry name" value="Invtbrt_color"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01273">
        <property type="entry name" value="INVTBRTCOLOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045016383" evidence="4">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="5">
        <location>
            <begin position="36"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005098523.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22190" checksum="7214E03EF7B51372" modified="2025-10-08" version="1">MKSLLTSIVCLAVVSLSRSASIHLGKCPDVPPQSTLDAAKYLGVWYEMERFPTVFERGNCISANYSLKSNGRIAVDNRYILNGKEHTILGEAYPEDENSTEAILSVQFPFSPKAEYKIVETDYSSYSLVFSCASIADIFNTQFAWILSRTRTLDKAVVSRLENTLAQYHIDVSSFIPTNHTGCAMDQPDIDPVMGRLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPP1</accession>
    <name>A0ABM0JPP1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beclin 1-associated autophagy-related key regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098614.2">
        <property type="nucleotide sequence ID" value="XM_005098557.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847342"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13664">
        <property type="entry name" value="BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13664:SF0">
        <property type="entry name" value="BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098614.2"/>
        </source>
    </evidence>
    <sequence length="530" mass="60151" checksum="C5D82680ADB0B3BF" modified="2025-10-08" version="1">MFPTNHMAIPQSTIVNRKFVMAASISQTRYDYKIAFQAAIKEGKIVPVAFEKCPLCCENRGFLLCDVCVNKGLFNHTQRRDSGRFCDKRQQLFDKRRERRELVKKFESHVEGLCRVNAKRTEIESAKKNIVLLKKAIADTKSKCITERIVVSQNKKRRRNLRAKLDLDQQETLPNLKLRITNLSDPDTQSLPTVLDVLRVRFDRDLNVQQLIALAATNIPRQRRPSGQLQEGTSIDPKSVPVLWQELQLYNQYLATQRRAFIQCMSQRIFPIKEIFVPSSSNLEMSMATALKDASETAFIAGRWVHVDLRGENHCMVIQSTLPEYSGDSSALGLFVMTNRYASENPDKVPVGNPSYGIQSALGYTNMFVSLAANICDVHLPRKCSFRELRNDISEYDFCNFVWRLHQNIRHWAASQKVECAQMVDYLSLRNLLAILESSGLGRVGAFEAQYRMPVKAELCPLEYESDEEELDASGPDMDVSRDWERVPSGLPSYEAANMGVSAPVDTSTTGAFLNAAASLTGWFKSYYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPX2</accession>
    <name>A0ABM0JPX2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101845328</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098775.1">
        <property type="nucleotide sequence ID" value="XM_005098718.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845328"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098775.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33592" checksum="0542790FF525BA84" modified="2025-10-08" version="1">MAQKQGHQQVSPRKSRYYHAKSSKRELQEKRAAVARRRAHATRHVVGRTGCNNPETRKSVGAVLIAVGVLFLIAGIVMTIVDATDNEQRNKYPEIFAVIGPVLIVLAVIILVSGITLSTPVMSRALHHCFSFDDPESFCRVHCPRFSHFLKPDTAVLINQAGMKALKVEPGKSALRRQPAAPPDQENHIITKGGSEDVEAQYNVQNPSEVGTISCDVDAERKLVNNNSHGRSRLGSKGVRFSESDDGDAVREARAPSVSSSSDHNGSMLSLRHCKVHPKNGIWWTDSVNPQPNEMSESEGHLTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQM2</accession>
    <name>A0ABM0JQM2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CDK-activating kinase assembly factor MAT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101856182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005099251.1">
        <property type="nucleotide sequence ID" value="XM_005099194.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856182"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16517">
        <property type="entry name" value="RING-HC_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057657">
        <property type="entry name" value="MAT1_CAK-anch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25811">
        <property type="entry name" value="CAK-anch_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005099251.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38414" checksum="0E512BB90F8F8218" modified="2025-10-08" version="1">MDEQGCPRCKTTKYRNPSLKLMVNACGHSLCESCVELLFVKGSGACPECGTPLRKSNFRLQIFEDAVVEKEIDIRKRVLRDFNKKEEDFPGLKEYNDYLETIETIVFNLSNQIDVDATKKMIDQYKKDNKDQIRKSQSKMSRDEEFLDTLIEEEQHNAAVRKMMDQEEVKREKAAKKKIQQSLIDDLMFSDMSAKDIISSHRQNIQQQQEEEQEARAATTAFSTGIKIGQHSDNIHLMKQEQGQVFHYCPLIMEWCGPEPPTMDEIYHDGYLRNIRAATDQERAGGFREATACHRALQDALCGLFSFPNINPSPVKSGGAAASSTASSSSSSHLPMVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQQ3</accession>
    <name>A0ABM0JQQ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Myogenesis-regulating glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC101850247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099310.1">
        <property type="nucleotide sequence ID" value="XM_005099253.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938502.1">
        <property type="nucleotide sequence ID" value="XM_013083048.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825891.1">
        <property type="nucleotide sequence ID" value="XM_035969998.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850247"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06592">
        <property type="entry name" value="GH31_NET37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021100" evidence="5">
        <location>
            <begin position="29"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="284"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="599"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005099310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012938502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035825891.1"/>
        </source>
    </evidence>
    <sequence length="684" mass="77065" checksum="422EBC79E0888FF1" modified="2025-10-08" version="1">MTRSKLIAIGLVCCALLTLVIVLSVVLTRDNDDDDDGGNPAPSKEPISLTENMQLAPKWESGSLELTVSGIPTAKIAPVTAYLGRNVELNGSRVCTDSHGIHCRSFVDGRRLEILESVKTSELDCVTVEWSSAGDVTSRESGEDCYDMLDTHWFGGFEENRQHWALDEFVMNSSAFVTGHAWDMGEYGDVIEPIFLSSAGVGIHVDEATPLYLSINEAKSKQLCLVGRTGANTPYYHGSQSASLRYHICKSSNIASLWKAMAEQFIAKPTAGVSEDVLHSPIWCTWAKYKGAINQTTTLEYANLIRENNFPASQLEIDDEWTPKYGDLVFTTDKFPDASELIQNLTSEGFPITVWVHPFFNNDSQAFQELSKKNYLLKDLHSAEPALTEWWRGNHAGVIDVTNPDAVTWYLNKLEYIKTNYSVISFKFDAGETNWLPKKFTSHVDLPNPNMYSKKYVEMAYRADLKERRQEVRAGYRSQNTSMMVRMLDRASNWSHQRGLKTVIPCALAFGIMGYPFVLPDLIGGNAMDTIALDHTVLPERELYIRWMEATTFLPVLQFSVGPWDYDEEVVNITRKYVQLHQNFSDLIVNLSKEAVVTGHPIVRPLWWTDPTDSTALTLETQFLLGNDLLVAPVLEQGAESRDIYILNGDWQDELRGGILRGPRWEYNYTVALHELAYFTRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRB6</accession>
    <name>A0ABM0JRB6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846585</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099717.3">
        <property type="nucleotide sequence ID" value="XM_005099660.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846585"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099717.3"/>
        </source>
    </evidence>
    <sequence length="102" mass="11428" checksum="DBE2A9975812E227" modified="2025-10-08" version="1">MKAQLITDEFNSWLEVHKPQCQANYNGSSGGMKVEGAKVLWGRSLLHKMRYTTLIGDGDSKSFAAVLVLNPYESIIPKKAECVNHVAKRRRLNVSSHTTQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRX7</accession>
    <name>A0ABM0JRX7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Failed axon connections homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100148.1">
        <property type="nucleotide sequence ID" value="XM_005100091.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847964"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="83"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="225"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100148.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34991" checksum="A3F9445C7A07E107" modified="2025-10-08" version="1">MALPWGWPGAAMLSMTTAEDILSSLQESPGKWLVTLGVAVPAFYCLYSRLKTRSPHKSSRTVPPGTVILHQFPRGPFAPSVSPFPVKLETYLRLAKIPYVTETDLNVSSKGKMPWMEFNGEAVADSHQCISHLNRKLGIDLNKGLDPAQRAVARTIQMMCEDHLYWCVAIFRWVLDREKKVIRKAFSQVNSLILWLISRKVREASLAQGMGRHSKEEIKEFLVGDLQALADYLGDKKFMMSDEVTEVDCCVFSFVCQFVYQQKDEDLQGLVEERFPSLYKYCERVKELVWPDWDDICAGRETRLSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUD2</accession>
    <name>A0ABM0JUD2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101852775</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005101695.1">
        <property type="nucleotide sequence ID" value="XM_005101638.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852775"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005101695.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26596" checksum="E0D455A0A34459A2" modified="2025-10-08" version="1">MIKSRAIALGCVSALVVICGIILSILLHFMVVNLVEGYKDSLTFSTSENQYGSLKTVTQNNYIWVAGLVFIVPGVLGFIAAFVQNKCMLVTTCIFSMIFLLIMGLMFFFAGFAIVVLIMAVGSISEQCRDTYEGCQCLSQDSNGYSLEYSNTPFKTCDYFATLASLIIGILTIIVIAWVIMLAEFVLACYYACRSKPQSSQGVVYTPAQQPMMAPQGQYPPPPYGNQQQPMYYDDQPPVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUW0</accession>
    <name>A0ABM0JUW0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101858644</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102062.1">
        <property type="nucleotide sequence ID" value="XM_005102005.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858644"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="258"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005102062.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42473" checksum="0B8142C2A233E685" modified="2025-10-08" version="1">MASVIRVKRRRNEDPAEALRLSCKRQRQSITSSVDEKNDGNADTEDAVQEIESVLSFAGTLSSKDEPVSRHIKEAIRKTKLHREMHPHSSGFRHGGPKDKLSNKLREQASESSRSNRYRVTWTRRALDLDLLDKGEESEKTSESAGSDNKENSKLPSTQSAGQCKNSGQDVLVSTFTTNSPAQIAEQKDAKLPPATKPAAPSALTKGDKMFCMFDVESDDEKEALAGLISGNDSSSGITMNGVPMVSTEVSAPLAESEYVYDLYYTHSNLSGLDVQAVLTVQSICDQFVNEEEEGPDGELVYDDEDDSNDESNWRNDYPDEDPHFFENDDGDCYYAEDMIDTNVLDDGDMLAQYLGSKCKVEADSDDDADEYGENEGSSDDEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUZ7</accession>
    <name>A0ABM0JUZ7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101855879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005102137.1">
        <property type="nucleotide sequence ID" value="XM_005102080.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855879"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="9">
        <location>
            <begin position="362"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005102137.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="68887" checksum="3EC963C4F966F290" modified="2025-10-08" version="1">MENEEIASDDSNEYEEGDSGSDDVDYYQYYAMSLDDPPGLPKVCPQLKNDMDMLTQVLSPKALEFRSFDDINEMDIDIFVSTASLEKSVAEAWGLVYQEPVVVRLCLNQRLYLEANDIMKIEVLQKSCSSSVVLSQLKKIIETFCREQFSKLDNEAVQHAVSKTLPQTACGKDNSLAEIFQMGFRLEDAQAAFTVAEGDKQKAVELLLTGFRVESELYVQPHTPVTSDPKEIPSLERGFLLQLHDFVQQRMKTLNEFCPICDNKHDVTRQSMLKPVVCNRELCIFALETLGVSAGVTFIMNTQPEVTNLLILLTKAAVLSPRHEKILEPYPSVVNPLRPNQMALCSSRKDHETLKVVLRRLPKLHPKIASSEADIRKLLDSQHELCYPLVRWILSSNRSHIVLLPRDQQLNCINTPYQFLLRNSPPVQDEMFRAKKESHGSVFAFHGSPLENWHSIIRHGLIVASGTDKQLHGAAHGKGIYLSPSIQLSSSYCGNKVIGIKNLPQQGSTTKGTQQGSKAKGIEKTPELDEDGPLELPSDTQRMICIALCEVINDPRHLNKLSTGIWTCTLGENVCTRFFFLFDNPLPFQGAPCVESTADSFLKRIKKVLKNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV66</accession>
    <name>A0ABM0JV66_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846433</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102270.3">
        <property type="nucleotide sequence ID" value="XM_005102213.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846433"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102270.3"/>
        </source>
    </evidence>
    <sequence length="832" mass="90173" checksum="5FDF94A5F18A49B6" modified="2025-10-08" version="1">MADRHVSRRLDEHVAHNITSHTGDRPAHQHNPHSELDRDPQHDPEQAATLFPRDGSSGGFEPDNNVYPPSESGTRSPYCRGHSAHSPCKSGRSAQAPLSDSGTTQGSVSGGPDSQGTTAPPSEGIQLTDPSTGLSVPVRDSCSSPSSVSSLQPGSAHRDSGYSTEVSPANTCSPANTATPPRPRYFLFADNDTTQAGSEGRGEGQDCQDISRSGSSQVEQFAELTEASLASATVSSALDELPGQQRKSLYERRLSQRVRHPAAPLRLSPDIFRRASTPESTPRALANHDDVTRLEESADRSYLERVQFDFNSDDDDEEEEEEEDDNEPTSGETDGKRSSSPRAGHGLLRQRTLSVVGTFDSSGNFIGRQSSSNDSGDNDGGDDDDEEVFYTTGVLGQQTNRMFRKDSFSLRTRRFCSDGDNGESAMGDNAPSRRRGGEGDHHFLSEDVRQTFHNEGATSGTSPGRLLASYGLRRRDEGYSPERKKRTDVRNSGHVTDSSRGSSPTAMLMTQNFRTDPALSSSQGFEFEPEPRHDEAIADDENRPDVCCEADEDVFTFDLDDNADSIGGATGGVLPRYVSSPSGRGRPGGSRMSPRGPGRSPTYHERHGRQTSRASPTGLVVTSSSSPLSAALCEHRPPQSPASRLRIRRTGQPLPVPLMDNVRLAGVSGSVTVSVSTQTPHQASMLIRQILTTPVALPNEARGTAASRLRRLSESGVPLPPSPVPLPDIIPVGRDRSLSAPDLQALARQRARRAGREVGRELRRLSDEFNLVFRGNLSPVHEEHGYSNSFPGMRPSYLRNPITHLRAIMRGTFGRSRESSVDLTDESEDRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV86</accession>
    <name>A0ABM0JV86_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prostate stem cell antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102310.2">
        <property type="nucleotide sequence ID" value="XM_005102253.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854960"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23599">
        <property type="entry name" value="TFP_LU_ECD_Cold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035076">
        <property type="entry name" value="Toxin/TOLIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036">
        <property type="entry name" value="CD59 GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036:SF3">
        <property type="entry name" value="PROTEIN SLEEPLESS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00087">
        <property type="entry name" value="Toxin_TOLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047197286" evidence="4">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Snake toxin/toxin-like" evidence="5">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005102310.2"/>
        </source>
    </evidence>
    <sequence length="142" mass="16385" checksum="7C8049F8FEFC087C" modified="2025-10-08" version="1">MELCLSFWLLLSLLGTGLALECYVCQNQMDNKDKCIKTSVQCREEQDTCLTFIEWRAPDFWTPRSEKIHYIHKNCSSSSFCGAAQTDLGLRCMRDWYRDWQCVECCQGDRCNFYVTLGSSVPVPSIFVLATSICAILIQHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW73</accession>
    <name>A0ABM0JW73_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101862051</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102954.1">
        <property type="nucleotide sequence ID" value="XM_005102897.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862051"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005102954.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15402" checksum="73FB7DDFEF9D8417" modified="2025-10-08" version="1">MELVGKWNHRPIIDAAFHPCVIAENARDEIKTSTDAYVTYVGTTYLGIPIDSTTNAIIIPIAVLIVLVVAVVTVCLVKWQTKKEREDRQLKRQMKKTYGTSGSSDAPPNYNILETTNTTFVSGATTTPRHGNGNKVVPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXC8</accession>
    <name>A0ABM0JXC8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat extensin-like protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103759.1">
        <property type="nucleotide sequence ID" value="XM_005103702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851208"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045704203" evidence="2">
        <location>
            <begin position="29"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005103759.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="44608" checksum="B8EF6E62CCBAEEA7" modified="2025-10-08" version="1">MSAAFQWCVVVVAVVVFFLTTPPTLVSGSSPVLYRANKIGIQLDTPPGVHDLPPDVPSPQSDYPPPESSQGRGGGGSGYNNEDRTLPLRPVLPQLNAYSPDPRDRARAESQPELKSFGERDDPIENRPPSSGRSSGVEPVSSGGYFVGSPGGKYVSPSSLQHSGGEDHTKPRVGLQGGAGPASLRGKPVEPRVHSRKPGAYTPNTPAYPPPPPVSNQPAYPAPHSPAGYKPAHNDHHGPAGYKPVHSDHHSLAGYKPAHNDHNHANQPNPYGNSNPGAYHPPAQQNLFPAAKQPGPVSQPMRPPSPPQAPSKDKTTNPISPPGIPANFPAPFAFPENLKINHKFPFPSTISFNSPRPFKNRSPSGFPSAGSVFGTGFPDPVDAKYTRRSPPVTEQQNPAPASQTGYPRYRQSPNLFCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0X4</accession>
    <name>A0ABM0K0X4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101851668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106164.3">
        <property type="nucleotide sequence ID" value="XM_005106107.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851668"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02389">
        <property type="entry name" value="Cornifin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106164.3"/>
        </source>
    </evidence>
    <sequence length="1205" mass="130897" checksum="99AE08770369B82C" modified="2025-10-08" version="1">MASPDAQENHSMDIPSLGMSELFRKAHFSCKFHGENVSVQRGFVSTSTYSKAHGQCLMQEPLTPGQTFQLSCCGTGVIKLGAFPSKRDAVNWLESGQHLGKFCQPLRIRIALLRSFDCSLEPYGRFLELNEKERLSGCWKAVYQLPAGPYTVLGFDIAFGDVEVSLSRFSSSFCPSFDRRFCSRHVNVHGPMASLKHDSPTTLSCLSLRHNWLRQGTSVHLRVSCIPSEPSMGYFRVCLSSYDSIVARGGGVQFTGSQDFPEVRGQLHKVKDDDIFLTIEVVDDKHVLLRMGWDPQAVDQRREVIFVDLSKRQCLVFEQFKVSLEVWKSEPQGNPTTPAPARSAVDGSWGHIPFPAEGHIPKRAKRELPKLPVVRPERSPQSDAATQVYADITNSGRESRHNSGPAMGTTPTHHGPMPVMEKGERQADEEEEEYMRMCRPPPPPRPHLTSRDIHIGLNEDLVTRLTYVNVGQEGDISASSRQRDRHSVGESSRPAAGRRILKQTYPLSLTRPDAKMIDMAGGAPVTNPGASNPADETSKTDVGSSNIGLPEHMKVRHAPAFRRRTETGTGVEKDGDHCSNYEDICLPAWARELKSRSGCNPSAERISSSQDKSKEEDIAGVNNARSKCVLSENVHTSEGEQESVDQNDNFCANLLDCDLVHPSESLMNTDHHKVSSLPSLPGSSGCTSLRGGEPAVDLDGTSDSSFMLCLRSSLDVGSRSEVLGTSHSLSLRPDVNPLNLTLASADVHFSPQDAGAVSFNECSRDIENLKERLPACTVPKRVVSSSRDSEDSDGSGHRRGSGSDSPDSLTCLKTCGSGQSRGSPDSMTHLKACRSGQSRGSPDSMTHLKACRSGQGKGSPDSMTHLKSCSSGQGRGRGSDSPDSLTHLKACGSGPQAEGGEDMLDGAPLQVTEALSLVPPVLPCRDGQRSSGSRINLNSPGDPKWPQYTAPKMKSTPHENVRRCTDGSTREDASLLCFPAAACESRAAAVSNLERCSSAPRAICSVQAWSNELNRPQRVHSVRCKPQTKVQFDWNIVQSSNLNSIADLKDCVDSNTDSSSSSSVETSLSCGVVTPESHNVATPEPRNVVTPEPCNVVTSEPRNVVTPEPRNVVTPEPRNVVTPEPRNVVTPEPCNVVTPEPRNVVTPEPRNVVTPEPCNVVTPEPRNVVTPEPRDEVISAPCDVILLETGSCITCPPHVLDALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1M6</accession>
    <name>A0ABM0K1M6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101861980</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106640.1">
        <property type="nucleotide sequence ID" value="XM_005106583.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861980"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044661">
        <property type="entry name" value="MED15a/b/c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33137">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33137:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="719"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106640.1"/>
        </source>
    </evidence>
    <sequence length="1324" mass="148492" checksum="4D28D70E48322A0D" modified="2025-10-08" version="1">MYDDLKRAHNKLNKAYVYAPHAVTVKAIVSQNCNCKPRLWRPCHWDTAVKLLLGQCPTSLASLKVPDKTGTSPGTGQRTTNRPQLCPSAHALALLRRRLTSRVVLALRIGEQYEQSASSFQTENPHCPRERRSLGNETGRAGTTGDHNGVLGEIVGILQEESILTQLLQIVDSMKNKPECDSEIHVMRTHSGVDRDPNGWNLEESGDKTSHTTGFGLPKVDETVSYGSCSFLRTNNELESKNSWERFIRECAKRDEIVDIHIENHNALKQLYAQGEGENHLTNTSQDMIQHSTEKSMVLTETENTFPKPNTHQLADSLVVLNSTFEDLKSQRDRNYDSNTSTVHQVGDMPSIQNQHFTESFTAAAYFNQRLIHPSKLFQDIAAGRSVPTGDYEVDSQLNMLHCNVSDENLNDHILLSNCQVTNKGNGNQKEKVDNRTMGHYFPNSPKHLQSQAAWDVNFPADRNSVGKRRPQTITSHEMDETCERKDIQTTHRGCNFSSKIMSGQDMNSRSEQERRSPRASFGNPFVHRPRITYKRNPTDMQSHKAPVFVFPSSHACGRQQSSSMAKMIPLDFNLNAVYKMNGQEYLDLAGPSLPQPSLHGCGGSHSEERKFSNSLGSGRGDQQVQTASTCDLCVMSGVQHAGQGEPAAPILPCLQKSFASDTAVKKRDTMTPTRCSEVLSARQMGPVVVVGGTSALLLAISIPLGVTVTPFIRLLWEVVLHMALIVLLLMIIFVALEANNLTDAVLGHFHLLANMLRSSSTCDVDHDTVDDQKVPEFSETAPTQTVIPGSFSEDLAVKTASNKELFHSNKATLTSFLSPSSQLSIDPEVSVPVDASTFINGIKDCAEKSNVLSEHDKDTPKCQLSLGEPTSDTSSVDVSTMTDHAESVDNNVGTVLPEKCVAEVMTEVVNLSSESTQTDDTIFSCDDGVVCDTGSRLVEIPLKAAKVETADACVLADMDAKRIYQQIEKVQQKHDHSMKRLRRKFLAMRRRCQIEAKDLKGNTTRKNEFLTKLQLTIPNLQKEKSFLLAERASVEKQFENEKKRNRELVCRLTKLNQYFYRLGQMQQTPPPVHWRQQTQAQPHNSVVPTLRCPAEGQSSNSQAQRSAATDRQQHLQQPLHQQKTHLHALGTQPHVQGAGSLPSPNRHQAGQHQQQQQQQQQQQQQQQHLLHNHALVLQQQQQQQQQHHHQHQTQQPPQSLLQQQRLPIFQLFNKTFSHSQDSLNPPIYMHIKQQQQQQQQHQQQQQQQQPQQQLPQQQQQLQHHPKTLQQQQQQHQYQLQQLQLPQRSNGLNSLQANDYNEQVHTGMATKTTGNVGNGSPRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K297</accession>
    <name>A0ABM0K297_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Growth arrest and DNA damage-inducible protein GADD45 alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GADD45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107041.1">
        <property type="nucleotide sequence ID" value="XM_005106984.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853028"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024824">
        <property type="entry name" value="GADD45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411:SF8">
        <property type="entry name" value="FI09246P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="2">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107041.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19289" checksum="63D796F6DFA228BD" modified="2025-10-08" version="1">MYTTDTLLISCGCNQFALANLSQDSSNEGAPSGEEAQRASMTISEALAACLTQAVRERRVASGVLDCAKLLGCRPGRVMLCILPEVRQHDVAVHIEHVLIRSFCKENDIRLLTVKDEQRLTELVTPNGESQESYVSCLLVESPVDGQSEADEFVCGYHDVIMARDILPKPVIQLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2I4</accession>
    <name>A0ABM0K2I4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Uncharacterized protein LOC101862064</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC101862064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107243.1">
        <property type="nucleotide sequence ID" value="XM_005107186.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828016.1">
        <property type="nucleotide sequence ID" value="XM_035972123.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828017.1">
        <property type="nucleotide sequence ID" value="XM_035972124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862064"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051186">
        <property type="entry name" value="RRM_HNRPC/RALY_subfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968:SF26">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035828016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828017.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="37524" checksum="8CD039DF056CE265" modified="2025-10-08" version="1">MRRLPRPPMGLPGMGPPGMGHLRPPRGPPPMGPRGPIPALGLPPLPGMGPPPPGHGHAGAVSSCTNSNDPASMDSRLFVGNLNTIALSKEAIEGIFSRYGVVIGISMHKGYAFVQFNHPDEARRAGASEDGKHYAGQAIDINIVSQPKNRNALKRSAGGRSVNEAQPKKPRNENVGSNQSLQRTLVTLSGSSDSNKRTAANNAVKRALATVSKKNVSKPPPTVKNSAPASKTFMARKDSGASQPAAVRSTWPDVLICGVCKMQFTSLHSLAQHKKIPCQLRLSTQARDDSNSPGGDNGEPDILLCASCDAQFNSGWALCQHCTQEHKMSIYKTEVKTDRAAKENASGAKSEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3R5</accession>
    <name>A0ABM0K3R5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PI-actitoxin-Avd5a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108063.1">
        <property type="nucleotide sequence ID" value="XM_005108006.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856535"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047122171" evidence="1">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108063.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8329" checksum="668C37A2B2F473DD" modified="2025-10-08" version="1">MASLKVFAACVLVFMGLVALGQSAPVDVRCEDMGCFALYDPVCGSDGHTYSNSCTLDVANCGKTGDDVIKQVSKGACGDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K653</accession>
    <name>A0ABM0K653_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Melatonin receptor type 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101846382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005109641.1">
        <property type="nucleotide sequence ID" value="XM_005109584.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846382"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="46"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005109641.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38528" checksum="25CCD8B1A0294B4A" modified="2025-10-08" version="1">METNSSLGPRSSPAPIELLPHDVFIIFGQILLYGVRPTAIVLGLFSNVLNILVFYKMGLKDSVNISFFALSLSDGAYLTLSSVSAVCDILVLANLGRQVMWVIQPSVILFFIYWYAVIFYDTSMLITVFIALVRCCCVAIPLKFKGVFTRSRTVVCIVVITVSTVLTRIPTLITQEIVAQYDVINNRTVYSLRYTADRPQAIELNDIMNRTAIWWIAITTMFVCVVVLATKLRASSEFRKSHDRGATSQASRDDRVVKMVILVTVLFLVLSLPFMLYSAVRQLVPKFNEVKGYTKLFSLITTISWALAYLNAALNAVVYYNTNSRYKAIVDAGVRAVFCGQAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6S7</accession>
    <name>A0ABM0K6S7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein SMG5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101849412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110077.2">
        <property type="nucleotide sequence ID" value="XM_005110020.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849412"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09884">
        <property type="entry name" value="PIN_Smg5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF7">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="5">
        <location>
            <begin position="75"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="4">
        <location>
            <begin position="199"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="657"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005110077.2"/>
        </source>
    </evidence>
    <sequence length="1087" mass="123165" checksum="5F77630BA467B1F1" modified="2025-10-08" version="1">MKRRVEPSNGSKSDTDRAKRVYRAALESIKCLESINKGQKAYREVFRQDAVGLRNKLKDYCERLMFYNPVEYGRKAEEVLWRKVFYDVIQVVKRNKDHVRRHGSVETAYRTHLAAAIGYYQHLLFRLQREFSLRLAGVIDYYLLQDQRPGRRGDTGSVKPVNPSVQEWAQRACHRCLICLGDVLRYICDVDHMAIPTTAERYYHQAFILFPEIGMPHNQLGTLAGSRYCGCEAAYHYMRCLACEKPFEGARGNLSRLFEKNAKRFYDLNKQGARDQPPGEQKSQDIKRFLTRFLKLLEIFHGGSPNMEMSELQELCQHTLQDFNLCMFYEPQHQMPTADCGDVDDPLEDGEEADGSGDPGDPISFLYLDNGIVFKIVCCLMCTIQLLEKTGSINVTAAMAFLLALFSHILNHVLMRLQARMDDLQHPNKILLAGSALSKENLQANDSSGSDEEVSKKVPQDNNGNISSKHASMSSDTKKSRPTRIRNLRRRRKRRQLSDSSEDAMSDWSDMSDLSEGKAEAEDQLVSSESDDDDLASYFDRGSDSDLSDTEECSQPTEPNNTRPQGGSTWPSSGHALPNGDLQHIWSNGVDNSGLAHMSSELFSSSLMFLGQDLANNPHASEMSQGNEEVPVPPGFMSSLEAKHVAEITEKLANFEIETDTETNFFPTDTEQSGNLTETDEADNEQSSSSNTEKQEMGQRKLQHRLEAVQAEGLLPTVKVMCDWMRGQVSIISVCAQSSHTLWQRLSLLLNFLPHENELSHHDVCWVQELQLIATQTRFSDWAQGFPLTEDIEMCQLPSLAEVHGQIDFTIRHRAQLTDMQETFLRICCLRRFGYFLTAIEGIDFCYQPETALFLGPSVDSNLPASSQDTMEKMKDTESRRNQLMRDMAQLRLQAEVRELEGSLKTSDQQVFPPYVLVDDAALCRHLTKVKELAATARCILVIPLAVVDSLDMKKKECTSAREVIRWLEVQLRKGNRYIRAQKNQETLLSQQHGILKKKNRDSWYILELLGCARYLAQQTGTFTGNNSVVVILTGEHKLLEPPLLPVIQQVRTSAQQEGVSVETVTEFIARWKSFLQQPPEQVTGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K739</accession>
    <name>A0ABM0K739_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-5AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110304.1">
        <property type="nucleotide sequence ID" value="XM_005110247.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862075"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="902"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110304.1"/>
        </source>
    </evidence>
    <sequence length="1150" mass="119420" checksum="326998A0BE0ECE36" modified="2025-10-08" version="1">MDMQGSPIVIDVHSDEDEDDDDVVLVKEEKVSPSKQQVDEKDEDVIFVSEVPARSQRGAKRGADNRPAGRQPGHGGQRNNNNSNNNDTNSDEEEDLFPLPTLPTLLCYPPGCAPINVVEDILRPLDLSQAALLEGHDPEEEAEHHPDSAPENGVPACTSSAALVSLANAQDSKPSVLSAEQNVTADSFTDSISSQGVNVSVASLLHAANSANSCSDNDSMQLDSIPHSANSANSQSDNDAMQLDSIPHAPNSANSHSDNDAMQLDSIPHAPNSANSHSDNDAMQLDSIPHAPNSANSHSDNDAMQLDSIPNGANSQSDNDSMQLGSIPHAPNSANCQSDKDSMQLDSIPHAANIANSCSDNDSMQLDSIPYTAKGTNSQSDNDAMQLDSIPHAANSCSDNNTVRLEPTAFSSAQDVPNNSSGRQSRDLAASTDATVGTVTMHEVSTVAGLTFDATPRTTAVSCATAAPDSESVAADVVSKDSSSSAKSDLREENPLPVPSPAPTHFSNNNSSGSTACLSVPNLSSDSSSEHKLDDLGLSGDEVKNLIKFLPSLLSENALNKTTCPPVSGATACDKSDSGLSVNVTTSVIPTSEDQGGVAIPQSPSLLQGGSATGRLLPSDEGEKTAAPGSSWDEMDASDRPTAQDMMCPSPPKKSCRSLRLRQSHGDEYAAAPTSGQRSEKSGVEMGKLGAASVAVSSGSVVGLRKHGQRSGGCCPKSGQVATRSCETGPAQGGQCTSTSVCASVCTTVSASVCTSRPVGTSSTLVCNSVIASPSVGSQDSYSAGDVAGTNSVGDVAGTNAGGTNSMGDVAGTNAAEKLTRSQSQLNTQGPPGTSCRSSPRTSRGPKPRAGGVCRHHKTLETSQWDCAQCFTARPARKPKVKARLSPGRRRSQSPLQEGAVSSSVTSPPLLVSSSPPSSSSQPPSSSTQPSSSSSSDGPVGRGKRRKVAEIRRAKSMLTRSHHVAGNSPRDAPSSVTIHRSVSDSGLVGQANEGGPGGARDDVRGGAGGRGEGADEAVPSCMCCRKACQLSALSFCVAGHGTCVTCLEAQVKAVLTGDVKQKNIQCPSDNCPEILDFAELKKTLPSFVVEILETKLDREYVSYITNWFFTNEQPLKPGPSSHPNRALRRTKNRRRISPAVGRPWIQGCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7E4</accession>
    <name>A0ABM0K7E4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101853890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110518.1">
        <property type="nucleotide sequence ID" value="XM_005110461.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853890"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110518.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="66362" checksum="BF91BF41E3DAE483" modified="2025-10-08" version="1">MMSETEASSSPAYNDLLARSIEEWFQYYIFAEDFLIVIKKYDRFFEVLSKQNIAQLQQLIDSKSKTPEAINSILLDYLKKGHPKWFDIVLDILRDTDLNRNFVAELLVQKKSELDLAIREGKVPLQGLDIPRTSQGSQEEQQRGHTSEGMRHLSTGSENFLPNTRSFLNCSNGLDRVTLESGRAGVSSCDIVFEENLNLVTGTEAAPFGDCAGSNDQHGMDHVASLPVFFSLTDEQTEVLKVVEDSKESLRKGAFGSSNSIGQTTVSCNHYPELPGREEEEEDRSLHCSKKQEEESDRAGVNEDIIGVTFLSGDAEYGGNGDEMMQNLTGVVNVTPDAQVTLDHQVRASVESPCGLLSEESNGETMQLSQALERDRMTENMKLEVGPVLIWEVKEDKRKNPELRSEHDAQVERTGQEDGDFTLSAESGTDMAQPTCIGTEQGMGKFEAGSFPTTTAESLSSTPAAAATKPLMSRQPPVYEINSDSADAATLYSSADESSIDFSENCLPHLAESDSSYLQPSDEMNHSSMAGTVIDAEPKIYKSHHVPSNSNREKIEKDITTVPKGPVYKSHFISRNDIKRPSPQQKITVYKSSHMKRGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7E8</accession>
    <name>A0ABM0K7E8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101858072</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110531.2">
        <property type="nucleotide sequence ID" value="XM_005110474.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858072"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="511"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="834"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="874"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="914"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="667"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005110531.2"/>
        </source>
    </evidence>
    <sequence length="1117" mass="127119" checksum="30566ECED9562290" modified="2025-10-08" version="1">MPSTIQAIDSTRSHSIKPAQGLRYGNFEGVRNLPPIRKSDSYSDQNLWSMNNEQIYRTVCQWMETWRPWQQRTLLCGIANRCSVNQLEILSTTLEPLRHRDYKTVSLGRYPSAPFKEDKKGSVTKPKKEKPVSRSLTLSRDKKKSILLADTLDNVADIEHIKSFVSDDASQVNQKPLRKPAVVISSDKAPESKRHSDSHEAQTGGPKEFPLPHEKEGAHTAEPVSEPIDQYASLLSSSIMLSALNDASALTFYDTNQFSTSREGSNLSKSKSFTEEGNEEMQMNEQKELDNCKSPTEYNLILKSKENNVEFLSDFLNGQENRKSSSIEKTDSRSLASERKSRPVTLSSRASSTKFLGGNLEFASQSYRSWLDREPSQSSQFRRSAFASSAATTTDFFDREKLAVLGPMQHPEGADSFQKHVDFSFLPIPLQKYYKNSRWWPAQPPQGKVFQQARKQELASNFKEQLLIIWDWMCEWEDFERIAFTKEVAKMCSADVLDVFLWHIKQRLQDSRDICRLPDKVLLYVFSFLSARDIFQASQVCRRWRYLCAIDNLWILKCLEMGEQEGVSNLPELIQQANKQGMSVDWKLAYCQLNDLMYMLRGSLEQTDESLTDGLPAEEEDSIGTDRIWTGIIRPTAGDFHEKPKSTVDGKRKVDKGKVTIRLNTGVRERLEQRDQRKLSEEGAGRRGSRPLDRDGSDMDSAFSEEDLAPLLEEYNMLKMEEPQVPTAHWSRTPRKSISQRLAPHDTLTEEATPAVSSTGRNVSSKGSSRSTKKEEEKEAALDIRTDLSQSRDILGKMVSRTNLEWETKETYADYMRTTLYAGELIPVKRMRRLQGHVNCISCLYFDNRRLVTCGLDRQIRLWDVRSGRSLHKFLGHKGGIRCVQFDNDIMATGSWDCLILIWDMKQFTNITTLQGHTDSITCLAFNGDLLISGSEDKSVRLWRRPTFYCMLTIRFDAPVSALILIDHLFAVATTDLCFQLLDVYTGTRRKKFEPPLGPLHCLAVHGQLLLGGDAAGRICFWNLETADMEAAVRVHDAAVNKVCYIDGRFFTASSDSTIKEWDLVTMTCLRVLRGHKGPVRDVMVSERRIVSCGDDASTRIWDLVLDTSKETALETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K874</accession>
    <name>A0ABM0K874_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TAR DNA-binding protein 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005111099.1">
        <property type="nucleotide sequence ID" value="XM_005111042.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859676"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12322">
        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005111099.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="29683" checksum="9EE6502F96EAFCEC" modified="2025-10-08" version="1">MIQRVESIASSGDRVVVNSVLVEGAQQMMNRKVFVGRCTEDMTAEDLRHYFSKFGEVVDVFIPKPFRAFAFVSFADPETAQTLCGEDHIIKGASVHISGAAPKASEKYDRRMVPNHGHMAYQGSWGPGRGGNPNSSSNMSVATGMGNNMGIGNLGLGALQLNHAMLAAAQAVLSSQTGWGPLGLTHQSAGATTNGDPLAAVTTTAAPHSMSASGGGSSYAPAAPMGGTGTAASNGSVVTPGAGATANNSFLGWGSQTTEMHPAPVPQHTVATSQIPNWSSVPKATSGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8Z8</accession>
    <name>A0ABM0K8Z8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenosine receptor A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005111720.1">
        <property type="nucleotide sequence ID" value="XM_005111663.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851237"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="73"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005111720.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41504" checksum="CFB3788897DAA7E1" modified="2025-10-08" version="1">MSHTSLPPRMSISHTWGNNSTYSRDDSLSLPLTTPSPSGLYYANIVSDQQWFIVQVVNVVVISGLLSLFGVASNIINIVVFAKQGFQDSMNISLMGLAVSDLCSLLSMIWICICVNPLFYLSKLPFDPRDILYLTGVMPHFLFVKIATFITAFITFERCLCIAIPLKVKTTITPGRTKTIIVSTYITLSLLMIPFCLGNRLEWVFDYSMNSTMLKTTYTPEKEMLEAISFLALGVLTTTFSFVFVICCTIVLIVKLNSKTKWRQTTAAKSDRVAGGVGVKDQKVVKMVTFIAVIFIVCAVPPTLLFFYMLFDIDFRIDGFYKNLYLVIWSSAFLTETINSSVNIFVYLKMSSKYRAVFMKTFLKKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K948</accession>
    <name>A0ABM0K948_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat domain-containing protein 24 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111829.1">
        <property type="nucleotide sequence ID" value="XM_005111772.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857991"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="641"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005111829.1"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112299" checksum="0CFA835D01BF693B" modified="2025-10-08" version="1">MSKLKVRNLFRSKFPRTKSTSELAEWTKSDEKLMKAVENGDVKKVTSLLAKKSLVPTKLGPLGRSVFHIACALGNDRIVDLLLKSTEDVNDLTIQGNSPLQLSAAKGHSAVVDRLLKASADVDLRDSNDMTALHHACAGQHLEVVNVLLQGHASPHLTEKGGKTPLFYSAHRGRDEICKLLLDKGAEINCQDILSVTPLMIAAKEGHRRVCEFLLRRGANADLKDREGHSALNYAIAAGHGELHEVFDRPPVRVFVDDPPSPASVQNHPESHLQSDFGLRISVEPHAAYDDGVDHQINETPVEDYVTDDESVSHIDAQSVHSVDDRLLSREHTSSASALLQTGAAADKTERALRELKEEHDQLNDDYSTLSVENLRLRDRVQSLLGRLNDKDQQGTETDQKDPIHEINNLKLLLEEEKEKVRALQEQDQTKVKQIAADDQNPNLDKMDKEDSGNTSLGTEEDVTLVKLTGGSGLNDGETIGMLRSQLLALKNENEQLKTAVSLPNGDIGSDKDVESEPSEEGKTAQLQQIKTMQFEIKQLHSHINERKDELEKHLLSSAVDQEELLQQNASMTSEVKGLKQQVALLEEALEAAKTEGPTEAQRLDALLEQSRNFFEEVSFDDDGFVNGRDMTKEEFLQSQNQQLKAHCSLLTDELEKLRATFDAILKAGDNLQADYDQQAAEKDQLQDELDLAVKEKTEVIKANEFLLTDNNALHDDLNKLVHELEKMQEKFTAAQAENEELKRSVGVASKVGEVARLLEERDKLQQKCEDYDSTVIRLQHDHGILLEEVQSLSESVTQLTAERDQLTADLEVMESVCQQNEALQQDYGQLELDFGELLKEKESLEQLVAGQEGGVTAAEKLQSVQSVAPSDETASLQVAYEQVAAEKDEVEASLEQLRLDNASLQDQVKKLESNQVDLLAANGNNNVGEEKESDSSEELSKSREELITLKKQVARLTKDVSEWEKRHSDTVTTYRTHLLSAVQGHMDPDVKDALYHIIELRSMEQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA80</accession>
    <name>A0ABM0KA80_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acidic mammalian chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101856395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112658.1">
        <property type="nucleotide sequence ID" value="XM_005112601.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856395"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF248">
        <property type="entry name" value="CHITOTRIOSIDASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046882972" evidence="5">
        <location>
            <begin position="25"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="40"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005112658.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46234" checksum="62F6F7CA02ABAE9A" modified="2025-10-08" version="1">MTLQALSLCILLGIALVVCQAGCARNHRVSNGHGGSDEKNKLVCYYTNWAQYRPGKGAFFPEDIDADLCTHIHYGFAIIVDGLLAPFEWNDDDTPWSEGMYTRVNKLKQKNPALKTMLSVGGWNMGTKNWTLMVQDTSSRQKFIQNAIPFLRQRNFDGLDLDWEYPGSRGSPPEDKFKFTYLVQELLIAFDNEPRPSGTPRLLLSAAVAAGKDTIDAGYQVASISKELDYIVLMTYDFFGAWDPVTGHNSPLYKADDSTSELNQYFNVDYASHYWVDEGCPKDKLYIGLATYGRSFTLRDESDSGRGAPASGAGIAGTYTREAGFLSYYEVCEMIIAGARMEFLEDQRVPYLVLGNQWVGYENKTSIGEKISYIQDNDFAGGMVWDYDLDDFDGEFCGKGRYPLISLISQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUW4</accession>
    <name>A0ABM0ZUW4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101851248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012934948.2">
        <property type="nucleotide sequence ID" value="XM_013079494.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851248"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1063"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1175"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1246"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1341"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1371"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1514"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1546"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1622"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1647"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1724"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2130"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2187"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2258"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2283"/>
            <end position="2304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2370"/>
            <end position="2387"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="319"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="625"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1022"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1514"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1820"/>
            <end position="2045"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="2217"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="2464"/>
            <end position="2698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="855"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2054"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="875"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="902"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2054"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2094"/>
            <end position="2112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012934948.2"/>
        </source>
    </evidence>
    <sequence length="2703" mass="304338" checksum="43BC32CF48AE7D14" modified="2025-10-08" version="1">MSLTMFGGDQEQVCLSFQPPEQNSSFCESTTSVEVEENLFIFADLVPLVPWIPHFFLWAVTPWYLICFLSTGKTTSPIGKLGKMKMSCTLFMATVSAVQLTRMSKIKVMLDSISGHYCCHWARLASLMLTTKLTTIERQRGTHYSFPLFVFWALMLVSDSLSFIQDVSSELYLRDPFTFVLCACCVIGALIHFVISSLPDSRVPAPDAHPEELTSLPGKLTLNWITGIVWRGYRNGLKEEDVPHLAARDRCQTLSPAFEKIWDKEVAVLQSREGTKNKQTDSLREGKCQKEVQPPKVNLLKVLLKRFGAEYLTYQSIKLFFELTMFVEPLLMGCFLTHFQHRDTEPSWKGYAIVMGLFASTLITNTGHNRVWTSVDRLSKNIKSSLKMAVYKKALSARNEGKRDITTGEIVTLVADDCEKLVNASNIVFLILATPVQVSVALYMLYQQLGTGAFVGLAIMLSLIPLNAWVGKKLKKFEKEKSDIKDKRIKIMNEVLNGIKVLKLYAWEKSFLKKVMYSRDQEVSLHKKMCLIHAGIDFMFCTIPFMVRVGGFMTFVCLGGYLDPSTAFVTTSLFAILNKPFSIMAIIIPEFVQASDALAKLNKFLNLEDIPEDIVKKTSVCEESITIKDGVFTWDRSSSKNCIENINVSIPTGQLVAIVGMVGSGKSSLLSAMLGEMEKVEGDVIVTDSTAYVPQEAWILNTSLKENVVFGTGYNTEKYNKVVDACALRDDFKLMSSGDKTLIGEKGINLSGGQKQRVSLARAVYADTGIYLLDDPLSAVDAHVGKHIFDQVIGPRGMLKGKTRVLVTHGVHWLPYVDSILVMKDGQIQESGTYKQLLEQNGVFSQFVQQVTMTGRNECESNRSTSDVGETVSDQDDKSSKNTEEIPKTEEVEPCSNKMEDEVKDTEEEIVEDDEEETQVGTLGMKVYMDYLKAFGFKYCVMCIVMFGLHTYFNESKDHLMAKWSDDDLLSNRLLAETQEYTDRSWNYLSSFTMYGVAEVLLSFGFISLVLCRGCEAAQHHHNKLLLNILRSPMSFFDLTPTGRIINRFSKDIGSVDGLGGCLRGYIASVGWLSVCFCMVLYTTPGIIPYMVPVTVVYLAMQRVFIANLRQLRRYRQKSRSPVFVHLNETLNGTDSVRAYSVEERFINKMEDKLENLMKFEMSEHWFHAWFDMRMTVLCSAVTLISGLLLLWDTRNSLIMFEDDQEQVCLGFQHPEQNSSFCESTTFVEVEENVFIFDDMVPFVTWIPHFFLWAVAPLYLICFLSSGKITSNMGHLGQMKMTSTLFMATISAVQLTRTSNDKVTLNSLTGHYCCHLARLVSLMLTTKLATVERQRSTHYSFPLFVFWVLMLVSDSMSFFQDVSSELYFRDPFTFVLSACCVIGALIQFVISSLPNSRVPAPDAHPEELTSLPGKLTLNWITGIVWRGYRNGLKEEDVPHMAARDRCQTLSPAFEKIWDKEVAVLQSREGTKIEQTDALRERKCRKEVQPPKVNLLKVLLKRFGAEYLTYQSIKLFFELTMFVEPLLMGCLLTHFQHRDSEPAWKGYAIVMGLFASALITNTGHSRVWTSVDRLSKNIKSSLKMAVYKKALSARNEGKRDITTGEIVTLVADDCEKLVNASNIVFLILATPVQVSVALYMLYQQLGTGAFVGLAIMLSLIPLNAWVGKKLKKFEKEKSDTKDKRIKIMNEVLNGIKVLKLYAWEKSFLKKVMSSRDQEVSLHKKMCLIHAGIDFMFCTIPFMVRVGGFMTFVCLGGYLDPSTAFVTTSLFAILNKPFSIMAIIIPEFVQASDALTKLNNFLNLEDIPEDIVKKTSVCKESITIKDGVFTWDRSSSKNCIENINVNIPTGQLVAIVGMVGSGKSSLLSAMLGEMEKVEGDVIVTDSTAYVPQEAWILNTSLKENVVFGSGYNTEKYSKVVDACALRDDFKLMSSGDKTLIGEKGINLSGGQKQRVSLARAVYADAGIYLLDDPLSAVDAHVGKHIFDQVIGPRGMLKGKTRVLVTHGVHWLPYVDSILVMKDGQIQESGTYEQLLEQNGVFSQFVQQVSMTGKNECESKRSTFDEEETVSDKDDKPFEKTEDISKTEEVEHCSNNMEDEVKDTEEGTAEEDEEETQVGTLGIKVYMDYLKAFGFKYCIMCIVMFGLHMYFNESKDHLMAKWSDDDLLSNRLLAETQEYTDRTWNYLSSFTMYGVAEVLLSFGFISLVLCRGCEAAQHHHNKLLLNILRSPMSFFDLTPTGRIINRFSKDIGSVDGLGGCLRGYIASVGWLSVCFCMVLYTTPSIIPYMIPVTVVYLAMQRVFIANLRQLRRYRQKSRSPVFVHLNETLNGTDSVRAYGVEERFINKMEDKLENLMKFEMSEHWFHAWFRMRMTVLCSAVTLISGLLLLWDTSISPGRAGVVLMYATNFMHCLGWVMHHSCHTETELISLERVVDYSNKPTEASWETEEENKAELSLSTQWPESGDLVLDNYQTRYREGLDLVLKGVTCHIKSGEKVGIVGRTGAGKSSLTVSVFRLVEAAVGKITLDGQHIAPIGLHDLRSKLSILPQDPVIFGGSLRMNLDPFGDKTSEELWEALKHSHLKTFVEGLPDQLDHECGEGGKNLSMGQRQLVCLARTLLRQSPVLVLDEATAGVDMETDELIQKTIRSEFRSCTVLTIAHRLNTVMDYDRIMVLDQGKIKEFDAPQKLLADQTSAFYSMAKDANLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVU7</accession>
    <name>A0ABM0ZVU7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 3A12 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101864130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935599.1">
        <property type="nucleotide sequence ID" value="XM_013080145.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864130"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012935599.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47583" checksum="12471FE87FCA31E5" modified="2025-10-08" version="1">MIKEITVKKFSNFTDKFTLTDRSANHPLFSKMLPFARGAEWKRMRSIVNPAFSSNKLKSMENYIGSCSKRLANVLNEKAEAGEKIDTRVIYGSFTLDMIAEILFGVGMDTLRGEKTPLFHHATTLLNNTPTFKFVFLAAALFPILRTPLRLMGYTQLPKKNLDFFVECSLDMVGDRKKSDAKRLDFLQLLLNAESQDRHIPGEEKKLNSFEICAQLCLFFVAGYETTANTMQFLSHSLAKHPEVQEKLIAEIESCLGDEEPNSENLVKLTYMDAVISETLRLYPPIPYLTREAFAACEINGFHMPAGTGIFIPTFAIGRDEEFFPEPEKFKPERFLDETSPVNPLTVLAFGFGPRQCIGMRLAMKEIKIALVYVLRKVKFVEANDIEWPKTLNPTFLQTANTVLVRAEKRSRSSPHHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWI5</accession>
    <name>A0ABM0ZWI5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101860881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101860881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935969.1">
        <property type="nucleotide sequence ID" value="XM_013080515.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860881"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1453"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1590"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1816"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1859"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2263"/>
            <end position="2284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1458"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1595"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1606"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1816"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1881"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2267"/>
            <end position="2276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012935969.1"/>
        </source>
    </evidence>
    <sequence length="2284" mass="254041" checksum="543E385C8D7E9676" modified="2025-10-08" version="1">MVATVHGIVRPSYEFQSRLLNDVYTEFNIDVKDIVCFEAHGACNRKDDEAELKAIDAVICSRRRDPLIVSSVKGNIGHTEATSGLASIVKCIISFQTKIIYNCVNFQVPNPASNALKSGRIVIPTSNFPVPENPNGLMAVSSFGFGGLGGHAVLRRCPDTVTQIADCPMLIPLTLQPYANFQDAAIDILRHMGDPSFYRFFLNSELSKGNAMWERSFFIVNSDKGSLQYFDVSSMDPVVTPVCVVFTDMISSPWSPSKDLMNIPSVRQTFELCDQEVIKLKPDRDGIPTMLESIKVPSPIETGGLTLRLSCQIALIELLKAMGALDKVALLRGEGVGGLAVAYADRCLSLAQCIRVALAMEEILVQENVDHQDTTLMKVSVDEDTVHQLGPWVRVLKKLEHGKYFIAVLHGKKNTVIQKLKEKGHTYEVLKFCVPIYCHNQDRLKDNLKTRFQKIIPRPAIWSAKSEVAGLKPRGNGVQTCSPEFLATLLSGPWDEDSVKEMFVEEKRIKTSSSMTNYSPWSEESVRGNLLSKPEDFYSEDHQMDLDSIRNDGFVDREKREFLVLKCFESSVKHEPMFFLEEELRCSGADRSDREVREIQPNSEGFLTTLGRIHVAGHRIEATRQLSMVETQPSMFTGYFPTDHLYGWTRTAHCETVDWTRTRASQRLPKTMCKRIFPPEYAAVSDPPGVELVHILLSSAAEFFEKDLQKGQVLAFDNVRLAHVTSIDTDHSDPGSVLCKVSAASKKFVVERVGSLSLLGSLEVYSENPVPEEYSFLDQVSRFPKDRSLKGLLKDMLSFLMNGYHELWPLRLIWDPSRHSKLCAARGATLQCSLGFTAGLMTCGGLIIQSHPSKGNSFKISDLCCPNPAECSSEAVSTEPLETDEQLILSRQTPSLSLRKTLKQVRFSPDQIFKIQNVKAEVPLTPGPVPKSGPKDRRKLHEEHASKKSVIFDFTQNLNNQCHSSAMERDRILEKSEENAMGLSDICCSGNLAIRADLGIMLMDILDSWPQGTSLHVYVVPPESPISEAPYVIYLLRQLTPSKVKDNDVAVLLRDRSTDLIEECHGVNDCLSMMSSFIEDLFVTHKVRLFAIKASLDHGLLSILEWEPLLLKKEMLSSKRMEKTISSEDSKNHSVCSMNDEEESKSCVLGDGETFHVCGMQYLTQLWRKNTIFSLELDDMFVKTLTKLTTINNHIVGFVVPQTCRDLDQSCDREHNENTIFPTSTERSRDDSRIFARLRSASDNMFDLPNGKLASEIHLTKTKSTSFDEDDIFEKMTNSSSDFPLFLMSVRNKGRGGKKSGRKKILSYLYCKNPKEILSFKNLDEMVSCLSQRFPGIKATHDVLFSQLTRETDNFDELLYHFWESDKCRDFSSSSLSSSSIYWSMENGSPFEEVMTPQFKDCPSVTVTPPKEAATFECPETVWDGSVRVAHVVDGSSCFQGLNVPDKENRRKACWPASETTDNTSKTGTPYLSKQNNTDIKIINTKDECSVPEISKSKGLEYSEVINSDYPEAVPQISCKNGSVPHTPLFGVLDACNRTVSDTAESHANYSSEVNNHVYSKNITPNTSENNSKDTIDVIAETSTDILGISDTESKSTSSDSAFSTPEMQKQSGNENEQNSKIIEYETQHFEYNKTTKEPCWTMSPDSTEKSTSSGNACNGSDVGALNIRRNDTSPVIVPFTSVCSAMDILNNKATDASNVGEDKAFISSVNDIGIIKIYDESNCKTPTSSQVKTKTSATVQTIENPAEHAVSNCFFCESSREKKDYSLPFTDNFEHSNPLASASSTVTSYKQVPDPSLIQNQSATGLSILQNQPASDNLETQDNSESEPSTRLASSENIEKENSKTTLCFAPVFLPSKDDKSNSGTLPKSSKEFRNEEEQPNVNSLKHSSAPGTAGGQNIATFDNACFLSTIAYESSEDKHSQQLISSVRIALIVQLYDRTGPEDPVNKKAMGHLLLYLTECEKEQGGDAYLGLVLVDNGKPSIHSRFRVNKHFSLSHLENVLNVIFALHILRDLGRLNSRNISKKTVLVQPPLYKDSGVMLLVAHHLGCKFVISASNLTFVIEELRTLMPRCIMLRDSVSSHNVRPLTDGQGCDVVIMFQPRHELFEFLSLVKTSGSVVLCGNVDSERDIGLSVFLRNISLHCVDAKHVVQQTMTMSPEKHAEFENLMEDTMSSLNDTISNLYPSGVEGYFYRVLGKVLELSPDHRPSEKDLLNSLFVGPETASHEYGNCLSVQTSVVCYIAERLLTPAPVSSSVIPSVFSPETADVSSSHSTPGPANLMEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWW4</accession>
    <name>A0ABM0ZWW4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Arachidonate--CoA ligase</fullName>
            <ecNumber evidence="12">6.2.1.15</ecNumber>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101855178</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.15" evidence="12"/>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_012936178.1">
        <property type="nucleotide sequence ID" value="XM_013080724.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855178"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="16">
        <location>
            <begin position="121"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012936178.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="76771" checksum="021FF0EE498998F5" modified="2025-10-08" version="1">MPDPNSAGSPPSALSTVQQLLSNVGPATLAALAASAATIAYVMSTKSRGPKALKGVVDLNNQSVAIDGKPEHRGSWFSTPPDYHHAERLYPDCDTIFDALLRGRRVSENGPCFGARTGPNREYEWMSYQEAIDSAQYIGSGLIHKGIPPKNDSYVGIFASNCPEWAVTDYGCQGFSMCPVPLYDTLGSDSISYVLNQCDIKAILVDTEARLNTVLSIKDEVLSLQLIVVLKEVSGEVKASAAAKGVDIVSFKELKELGKENLKDFTPAKASDTFSICYTSGTQGRPKGAMLTHESFLCMVESIIIQVKADLPFSPADVHFSYLPLAHNFDRGVHVLALISGARIGYYSGDVTLLMDDLATLKPTIFPSVPRLLNRIYDTVQAGVKTSKVKSLLFKWAMASKMKEIQQGIIRKDSFWDKLVFSKVQEKLGGRVRVLISGSAPLSSDVMTFLRCAMGCVVLEGYGQTEMGAGITFQLPGEPGAGHVGPPLPGYQVKLVDVPDMQFFVKDNYGEVCARGKPMLKCYYKNPEKTAETIDEDGWLHTGDIGTWLPNGTLKIVDRKKHIFKLSQGEYVIPEKIENIYIGSPFVAQCFVDGDSLKPSLMAIVVPDVLYLEKWAPGAGFPSDVKGFCSHARAKEVVLKDIMVCADKRGLRGFEKVKDIILEPELFSIDNGLITPTMKNKRNALSAKYKEQIQELYAKNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWX1</accession>
    <name>A0ABM0ZWX1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WAP four-disulfide core domain protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936185.2">
        <property type="nucleotide sequence ID" value="XM_013080731.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856566"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012936185.2"/>
        </source>
    </evidence>
    <sequence length="114" mass="13004" checksum="C3716D2ACF070D76" modified="2025-10-08" version="1">MLCCYNGCGQVCTEDTRVRRAPKRGTCPRVFRDSNAVCTDECASDYQCPGLQKCCNSECGRQCTMPCFHWLTRSSLWRVSPRCGSRATNQSPRRHRHSWKRNQSGGPTNPWLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY76</accession>
    <name>A0ABM0ZY76_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Frizzled-related protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC100533444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the secreted frizzled-related protein (sFRP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936954.1">
        <property type="nucleotide sequence ID" value="XM_013081500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100533444"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF148">
        <property type="entry name" value="SECRETED FRIZZLED-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="9">
        <location>
            <begin position="118"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="10">
        <location>
            <begin position="248"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="133"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012936954.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="52686" checksum="945C59D9C8F7D732" modified="2025-10-08" version="1">MEAKMASSSSSSSSSSSCERPAGVSLLSHMAGDMPTTSSHRPRGSVYSPRASLSFLSVLIFLYVFAVCVTTAASQQYNNGEDSLYNYYYHHDSNNYNGMDEYVSDWSQHEWAKMSGRIQQPKCVDIPSNLTLCQGIGYETMRLPNLLDHDSLKEVTQQAGSWVPLTRIACHPDTKVFLCSLFSPVCLDSLDRLIYPCRSLCQNVRASCESRMTIHGFEWPAMLECEKFPLDNDMCIMPIHDIKPDNNCTACKHPQTHEALIDHFCRSDVAMRVTLKDRRVLGTDLELVLRKRRKLYKFENMEKKEAKNLPVVIAGGTACTCETINDTQGKYLLMGNKRNGKIVINFGMAWKRKDKEFRKGLRAIRKGDCKQLFKTVIDNLHEDQKQPGSSKKERRRRKKKQKRGKKGNKKGRKGKRRKGKKGRKGRKKGKKGEDGGNKMKKRDNAMSKSELEDRALSNFLKAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A032</accession>
    <name>A0ABM1A032_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011787</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938093.1">
        <property type="nucleotide sequence ID" value="XM_013082639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011787"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938093.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25683" checksum="6ECE148CB446E628" modified="2025-10-08" version="1">MVREQNKVNDVTKNPGRLPSGGKWANERRPPAVMTFAEPTYFVGRGELSDPSQSSSTPGKDSNKRPANMASVIGSSAVGDFRPGEFPGTNDVNSFQRPANDVDPTEDDNTATDGSATSGVPDTNKDVDAASEMAKEPEQQDDRTGAGFNPDIINNMSFNVFNPSRMLSDQKNRHEKHTMFKRAVDQTFPDPSLYTTKSPFLWGQVQGQDGVSMSQWQSPSRNGLFDPSAWADYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0B0</accession>
    <name>A0ABM1A0B0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860572</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938219.1">
        <property type="nucleotide sequence ID" value="XM_013082765.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860572"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012938219.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49672" checksum="E22C5FBEC38923FE" modified="2025-10-08" version="1">MSGLLVQTGDVIYERYLEKTLGRVLPECLQYVSEQRPGDPIECISALLYRAVDSQEYYRERRRYLHSVRHSQVLTTSDETRHQTRIQQLNGGLTQNKNQLRQDRRKEKEALQSLIRHEEILEEQEVEIKSRVKELTRLLRERPLIMNLHAMKARLHRAHQEAARKAREAALRALAELGVDGSSYSSGFPNPLPPISSSRKLETGDKNDSTILFSGRDDGGGNEGEGEGEGEGADQGEGQTRDGALRRKRSIKASTTLSSMTLGSSVDTTQMSAAEIEKKKRERHAAKKKAKKQIEAALARGNYELTEKGAIIYASRSWEKLGLSAPFAKRRPLPESPILWSERGYDCRVMYEHEIYTRCDPDDVTGLPTDLPRMTLEEFLMPDSTPEPEEDEVSKPVSNPAAHQTKSKGGKKRKRSILPRLKRRGLSRDWADCNNLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0M2</accession>
    <name>A0ABM1A0M2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine, glutamate and proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938414.2">
        <property type="nucleotide sequence ID" value="XM_013082960.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864662"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01021">
        <property type="entry name" value="GEWL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002152">
        <property type="entry name" value="Glyco_hydro_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31698">
        <property type="entry name" value="LYSOZYME G FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31698:SF8">
        <property type="entry name" value="LYSOZYME G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00749">
        <property type="entry name" value="LYSOZYMEG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045156515" evidence="1">
        <location>
            <begin position="16"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938414.2"/>
        </source>
    </evidence>
    <sequence length="384" mass="42202" checksum="CE8F748C4C6B0F40" modified="2025-10-08" version="1">MILFLVLTSLGVAYGTNYKCHGNVMVLTVSGASSSTARQDGLSTGGLQSSYKMADNDYSELNKRKTCYYQAGKNNCIQPAVVAALASRESRGGKLLYRTKGYGDGYHAYGILQCDGGASGLHSKCTQYAWDSCAHIDFMVKTLLVPYINQVKAKHPTWTQDQALKGGISAYNAGVGNVQTYAGMDLGTTGNDYANDVCARAQRLISHYHWDTLPRYEYFQTTESDDRPNPAVMGTPFYVLNLAVLPPRPDPIPQWSPRTISTVFIYQPFPSSRSGGYGNGGSSYGILQCNSKTTSLDCDKYAWDSCQHINFMVHSFLIPRIKAVRQAHPSWTQDQTLQAGISVYNTGVTNVQTVAGVDSSTQGRDFSNDVCARAQRLINHHKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0M4</accession>
    <name>A0ABM1A0M4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011861</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938416.1">
        <property type="nucleotide sequence ID" value="XM_013082962.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011861"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031526">
        <property type="entry name" value="DUF4698"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34754">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34754:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012938416.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15439" checksum="D44F30C128323E23" modified="2025-10-08" version="1">MPSRDPRLYVKAVPLPIDSQKGLKLQARSAQVYNPTSPTRDEVRQWNYNRRLQQRTDQGFYAHNFRPYKGLGDPFYLEEKKLILHALGQWDETVEWETSSSSEDEDDGEATFAIAPQSTMVSCLHLNLLGYFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1C1</accession>
    <name>A0ABM1A1C1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101859863</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101859863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938830.1">
        <property type="nucleotide sequence ID" value="XM_013083376.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859863"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012938830.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27222" checksum="377D1736923CE70E" modified="2025-10-08" version="1">MKCSWTHPEEYLKPKDISVDCNYMVLTDTKFDHPCPQLNYTNALWDADSFRAATYYFVEVGVTNTVVNLTISVTKEFKVNEIVKPSPIKDLIVLTDRAAPSCILLSWKHSKTYYNKVFRIKHQAEHQTDPDILATNWNQTSFKACGYGPMTEHWFTVDTLPSDPLSGYWSEQVTGSGWTVQTAPSVGPLISAGSYVSTKCKSGRRNVTFYWNKWKGTSTQCSPENRFSYTNRWPDSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1V5</accession>
    <name>A0ABM1A1V5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell division cycle protein 23 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101849892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939127.1">
        <property type="nucleotide sequence ID" value="XM_013083673.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849892"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="8">
        <location>
            <begin position="14"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012939127.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="67567" checksum="58FD669D98E2EDC2" modified="2025-10-08" version="1">MADAEIASLELPKVKADLIVAQRECYARRLTHAAKWAAEMSKALEVKVDPRGLQEPEQAEDFWDEYDAYVLAMSYFDLKEYDRAVHCLRDCQSPKPYFLRLYSLYMSDQKRKADNVRDSNAQLEPFENEVLKILQTELAEKYVKKKLDGYGLYLYGVVLAKLDIHTLAMNIFVESISMEPLNWAAWMELARLISDKEMLMSLKLPQHWIKLLFMAKVYMELQLHDEALLIYKAFMDKGFSQSAYIVAQGAVTYHDMREVDQAVLMFKLLEGMDPYRMENMDIYSNLLYVKEKKSDLAHLAHRCCTINKYCVETCCVIGNYYSLRSQHEKSILYFQRALKLNANYISAWTLMGHEYMAMKNTSAAIQAYRRSIEVDKRDYRAWYGLGQTYEILKMPSYSLYYYRKAQALKPNDSRMVVALGECYQKVERLQEAKKCFWKAHCLGDAQAIALVKLANLYEMLNEKEQAFQAFTEYINQADRLLIHNHEDLSQAYKYLASYHIAHKNWDEAYAAAQKCTEFTETREEAKSMLRNIQTQRGQEEAGPSVSMHIDDSMDSIAQVDQLTGGAARTFGRVTPVNLKFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2C2</accession>
    <name>A0ABM1A2C2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012117</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939412.1">
        <property type="nucleotide sequence ID" value="XM_013083958.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012117"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012939412.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19595" checksum="D879DDB5517C15A5" modified="2025-10-08" version="1">MATFKTVEEGIKESLANVHPPWKVIWQRVPWRRVSNADTQARNRRPTVDRNTATETRNYWRPKIPRIIPRAKSCPANFLPFLTMAVLLYYEQGDKICRMFCRRDDCPEEKFRSRYVLQPCRPEVRRIRQVVHKGHCDCPLVQCKDKNKNKKKKCPPIAFAPCSPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2C4</accession>
    <name>A0ABM1A2C4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012939415.1">
        <property type="nucleotide sequence ID" value="XM_013083961.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847882"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044976369" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012939415.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="57733" checksum="85A38776F1D45FE2" modified="2025-10-08" version="1">MAGRAHLEFIVVVLLTITISLVWECQATAPTVSAPAGRFQGLLENDQKGQPYFAFRGIPYAKPPVGELRFALPEPLPKLDGTFDATKHGHICPMPDMLLELVDREQGKEDCLFLNVYAKELAPSSLKKVLVFIHGGGYIFGSSNECDASTVVTTHDIVFVTINYRLGVLGFLSTGDQSSPGNFGLWDMTLALKWVKDNIASFGGDPNDVTISGESAGGSAVGYLSISPHTKGLFSKAYPQSGTPTSAFGKALDPQKDALTLAASVNCFEGDASQKADSDTTRKMIECLRKLPLSNFTQYLALSIDRTVFVPIVDKDFVPRPPLQLLRDDSYLEDVGFFKRSYLVGIDNNEASVVRPYVENFLAGMIKSRGNITDNEKTELLKSIRSSTYDFYARSRMDAPVSTSIVDKMVSWYDRRFGDDTLTMLISDLGFIVPTFDFIDAASRGKDTKVWLFHFNHFPRFMKGKEKGIVHGLDLCYWFDLSVERLEKILRHGMDGTMGMDDEDLDLKSRLSAIIASFTNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A344</accession>
    <name>A0ABM1A344_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012207</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939859.1">
        <property type="nucleotide sequence ID" value="XM_013084405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012207"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="1">
        <location>
            <begin position="78"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939859.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42104" checksum="994F4B6CBD35FF0B" modified="2025-10-08" version="1">MLSQNYPVAARTAQQAVVNGHHDVYKSPFSDSGEEGYQWRAGRQSLEQILREEKLPLVVRLGTESVVRQKETPVDLQRPILLFQEVKEKKLHARNIQSRAAARDNRVIYQEVGPDVIIPQTFEGYFRPLDGKDQPLTSTADLARLMPEMFLSCSPCEGYSCLSKIGGNLYQKGVLPCGIYYLKNVLEESITYLNKRKSEKKKLLRCLSCEDEHGKTVLFPMDGNRSFYVAKPGSRFPKVHLDSSSHFRVYRWTDFEAPRLKGFRVKMKHGTPPKEDCHFTGFLEFRHVTEDHNVIGCTMTSSPRLFEMAVTTEPYFNVAMNSGSLDTTDSLQQKCLKYARQESQLYLNTIKVRKDYDIEQPDAEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3K8</accession>
    <name>A0ABM1A3K8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin polyglutamylase TTLL11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940141.1">
        <property type="nucleotide sequence ID" value="XM_013084687.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847739"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF154">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012940141.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="59159" checksum="55188F726DC651D0" modified="2025-10-08" version="1">MSEEMDVSNGSPPSLEELEQTKGAKPVTIDTSCCGDNIDILKIMMPYMRWKQVDPGYPCDIYWHNDTFLDQTGIMSGQVNRFPGSREICQKVNLCRWLIQMQSLYPEEFNFSPKTYLLPEQYEEFAAEVRPRTLNTYIHTYIFPSFKFDLRIHAVIRSVSPLEFYICDEGQVRLATVPYTKPTAENIHMTTMHLTNFMVNAKSQSYVLCDEDNEGSQRLVTSVLKTLEKEGYDTKLLWQNIELLVAKTLTAMAPQMLVDYHAAIPDDQNGPTCFHIVGFDILLRDNLEPVLLEVNHNPSIRVFDTVMRPTGKMEKAFAVKSFNMRRKLLRDTMLLVTPKGRYSRPRRRPQPQQGDTDKKVTGPYTPDNVEVEKNEEGEDKSSLIQLVPKLYGKRLQPCRTLERIAEIFIASVPSTGSAYMSRSEFKDFVKKCQLDKNMSSSEVDKFFCATEQANLHLNPKGTSGLSFFAFVSACTEVAAAEYPSLSSAEQLSSFAENCERLLGLPGLKTGTFSNGSFTPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A480</accession>
    <name>A0ABM1A480_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101851966</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101851966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940513.2">
        <property type="nucleotide sequence ID" value="XM_013085059.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851966"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012940513.2"/>
        </source>
    </evidence>
    <sequence length="199" mass="23013" checksum="7589560F980BE417" modified="2025-10-08" version="1">MCPMKYMDLSYEGRQLSERNQFDNGKYPHGGYRGARKHPPCGLSYDKGREFKEKVDEEVIRLMTEDDINLHGKSPTWSLLVHREPTFSDESPLIAGNFMAASKHEQTNGVNLLSRTSLLPAKPLRVSRKQNGVKYYRPNRMHQYLSATELKDSSREQVNIAYGRPTRTTLLRARNRCVPAQTNTHETRKEFFQSEYSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4W6</accession>
    <name>A0ABM1A4W6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940891.2">
        <property type="nucleotide sequence ID" value="XM_013085437.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012443"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940891.2"/>
        </source>
    </evidence>
    <sequence length="367" mass="41600" checksum="B269E5E90EFC5703" modified="2025-10-08" version="1">MSEDSDGGRSYKSKSVSTNSSRQGGEKSRRQWLLDKRKVGQDRSTPEDSRRQKRVQDMKLKSRRTAYTTARLSARLAVLDMYMHKTLVDDVFLGKKELNPRKFEKDQTLNKRWKFVNDIVTTQEMIVSIREARARERAGRGNAGKQETIPEQEPAETEDRTNDVTTVVTSADAEEEPRECVPEVEEDVQQSAEAGEQDTTVPDDEKTTVDLQDHPEPKSDAAKAAPEIPPAQKSKAKADPSSVRGNNKVVVQTKNRLLVHEHPVYAFWSSHRKEKCTYCVMKYGQQKSPARHVRSSHLSASPEMIRRVGDMREIYQNEVPAHVKFRKKMEDRIGEIETIAKGKTNRKIAESSKKSVGSSPNFFTGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5R0</accession>
    <name>A0ABM1A5R0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-linked oxidoreductase pynB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941348.2">
        <property type="nucleotide sequence ID" value="XM_013085894.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851519"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Berberine/berberine-like" evidence="6">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012941348.2"/>
        </source>
    </evidence>
    <sequence length="367" mass="40489" checksum="D24195DCD3D3D095" modified="2025-10-08" version="1">MTGGLGPLSRTLGLAADSLQSARMVLADGRLATVSAGGVTVTDADGEVKTYEDYDLIRALRGGGITWGVPVSFTFSLTPTPVQFASLTASYLIVDNGQVTGRSTLRSILGQMASLNVQWGGYISIDGAPSNSFPNDRGEIKYHLFSYGQYVQNPNFNTAIENLRNIPTSLNGQVPVITTLSTLRQYRNDVAEVEQHFTSKKNTYVMNTLLNADVITDPNKLDQFVELMMDVVNSPTVTSNYRCVGKLAGGKVGSPNSNTYVSEKMRDALFSWTCALSWDEGITREAYYIDQALAFQKRLRALGNGGVDPYYASEDLEDWRTALYGSSYYELLNIKKTWDVDNYLWAHNAVASDFELSCNNIRCPHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6J3</accession>
    <name>A0ABM1A6J3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Triple functional domain protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101857271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941788.1">
        <property type="nucleotide sequence ID" value="XM_013086334.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857271"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13240">
        <property type="entry name" value="PH1_Kalirin_Trio_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047054">
        <property type="entry name" value="Kalirin_TRIO_PH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058918">
        <property type="entry name" value="KALRN/TRIO-like_spectrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23323">
        <property type="entry name" value="Spectrin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="11">
        <location>
            <begin position="84"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="10">
        <location>
            <begin position="1283"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="1470"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="1661"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1242"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1640"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1738"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1831"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1247"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1640"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1744"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1856"/>
            <end position="1869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012941788.1"/>
        </source>
    </evidence>
    <sequence length="1881" mass="214889" checksum="14D13404D3B72466" modified="2025-10-08" version="1">MSWSGRSRSRSSSRSSSGKDLCSHPEGSDQLKTKSGHTHSQGWTVATYRHNNVVVKFRGRRNDGLKAADIVHVLRERVAYLSGGRDRRGGPILTFPSHTHPERLKHDDLRRLMTYLASVPSDEVRDRGFTMILDMRGTKWETVKPILKALQECFPGNINMAFIIKPEKFWEKQRTSLGSSKYNFETNMISLDNLNKAIEPNQLTREFDGTLDYDHEQWIQLRLMLEEFIWKALDLLDKLDELGEILTNPELPDDLNGAQMVLEEHNHLKKRVTMAPVEQLAMEGHQILQRITGEYSGTGGRRYVISGNADFQSAVPQISQLLDNLQSTKQHLNQLWSVKKMRLEQCLQLRIFEEDVEKMFEWISHNRDLFLVNYTEIGTCHQMAVELESEHCQFATSAENVYVNITRILGMAQRMCDSGHYASNTIRMEGGKLEREWKSLAAALEDRSTVLRMSVVFHKKAEQYLAQVIVWQNTCESLKIPSGIEELEEALQQHQNLIETISQTYAEVCGDGKALLDTLQTPVTSSSANSITAKADYSEAAGHVLDVVHEVLAHQRHLEQIWHGKKVKLHQRLGLRLFQQDVKQVIDWLNNHGDVFLKKNTSIGKSLQRAKALQKSHEHFESVARNTITNAEKLLAAADELAQTGECDATEIYSEAHELEQRMHAFLSGLQRRRAVLDMTVIFYSHVHELTNWLEELHTELQSTELADSVEGAEQLIGQFNQQRETTVEAAINTVGEGETLLEQLRLISMETEKTGHSADYKHIEGVLSQLNDSRSQLEDLWAARKMKLDLCLQLQVFERDAMEVSSQLELLSEELQHMEMVTDGSKAEQLLQIHNESVMHVQNCTYEVIQRGQELAQVMSESDHEATNRIGVLLEYLNERQVDLEGLAEQKRLRLQQCVHLRNFEIEARQVILWVRNGESMLTDSFMCPNSLVEAEQLKKEHEQFMIAIEKTHFSLVAVTQRAEGMLQQQHYNAELVRAMAENVTLAWQQLMYHAEERQKLVMASTNWYKTAEQVWSVLESLDRDYKRDEDWCNSDKAGTTNTQAKAAYLVQLINKHSEQKEAFLRACTLARRTAETFLKYVTRNLHFLGMQMKFRSPEQRVKATLTKLLQQENLVLEFWTMKKRKLEQCHQFVLFEQSAKQALEWIHDYGEAYLASHTNVGADKNETEALLKEHYEFRNRAKETKENVKLLLQLADDFVTKGNIHATSIMEWCSMVDKRYKLFSSRMEKYRLQLQAKLGVTPQEQNEKDEQRQSDSSIEEKLEQTSTGKEITEEKRKSARRREFIMAELLQTERTYVKDLEICINCYMKPMSDSSINVPAGIHGKEHVVFSNMDEIYEFHKDVFLKELEKYESIPEDVGHCFVTWAEKFSIYVTYCKNKPDSNALLVEQAGLFFEEMQRKSKLNEPIASYLIKPVQRVTKYQLLLKDLLTCCEEHTGEIKEALEVMMNVPKKANDAMHLSMLEGMEDNLEALGEVLLQDNFTVWDPKQLIKKGRERHLFLFDVCLVFSKEVKDSNGKSKYIYKFKLMIAEINITEHIEGDETKFALWTGRAPISDYRIILKASSLDTKQQWVKKMRELIQERVLYLNDALKDKQATMFKPPPKIFNTSRVSRELEGEAGALEDMTALERRGSLMSIVSSTTTGTNDSSSSGGGPGQAKGAPELTVVMEDYAASSPKEVSVQRGQQVEVIDASPGQLDWCLVRTLPPDGADSAQGLVPVSVLKPLAFLQTPGARNSIDLDDSMGNTEGTSSPVSKRRSSFKKWLTTPVRKLSHGKIEKQGGMLLDPQRALQRGDRRTLINPLGADRDSTGGESVVTGDQTIAPQVAVVNQKSPLDATSEEEEPAQDIEMPPPMEIQEHSFKPDNKEVSTDDVTTKLVSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6S7</accession>
    <name>A0ABM1A6S7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012714</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941935.1">
        <property type="nucleotide sequence ID" value="XM_013086481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012714"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012941935.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19026" checksum="DC5E86D1F19CB3E6" modified="2025-10-08" version="1">MAAFGTKKELKGRDGRKKVINMNITKVYTPTNDAEEDNKDAFYNRLQSGIDKLPGKDINIVMGDLHAKLGPDNSHCGEIMGRHGLGEANDNGERFQSFCAFTTWLWEERSSHIKRFIRLLGPPQMGRRKTRLIMFASPENLDAHWRTSESYEEQTSHQTTIWSLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7C6</accession>
    <name>A0ABM1A7C6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101850666</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942260.1">
        <property type="nucleotide sequence ID" value="XM_013086806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850666"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942260.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20432" checksum="6ABF5215DB763F0E" modified="2025-10-08" version="1">MGGLSVLFSIIAINLHFRPEEETVPKIIRKVTRLGMFISCFNTCCKRKVKPEENGLSRTEHDSRRKYNSQAVDSENQVDDPLDNSPNRTRSPESLMFKPPWHRQGSGFGLRAPTGKFGQRSRGDVNDTDYARALSKVKGKSEEPEMTWQLVAKVMDAVLFRFYFLFLIVSTSVIMITLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7I3</accession>
    <name>A0ABM1A7I3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012815</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942345.1">
        <property type="nucleotide sequence ID" value="XM_013086891.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012815"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046415651" evidence="1">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942345.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16922" checksum="72716486BB107154" modified="2025-10-08" version="1">MKVVAILAVVAFVTVQADFVAYLKEIQTHRSFQSLSIEDKVLFAELVQAAETDTLQAFIDRVTLLKVVELMDRMYYVDAQKFSGYLAEHLGYHHHTDTVKDDIINKRDDDDDDDDDDDLKFIQIFLVIKCQYSRPFFHFTIQHMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7N0</accession>
    <name>A0ABM1A7N0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101847138</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101847138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012942422.2">
        <property type="nucleotide sequence ID" value="XM_013086968.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847138"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="213"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012942422.2"/>
        </source>
    </evidence>
    <sequence length="346" mass="38326" checksum="BD6B3BE5FD7438A4" modified="2025-10-08" version="1">MTCVDGRCSEADLSSPHIASSDGVEIITTHNKVHEGYTEHLTINCSFTHQQGSDFYSIVSLILYKTDSPTDTVYREVASITAFSHNKVEETNTMGSTVTGHHKPDAYSFIALEWLYPTKNVVGKYKCEANGIDHKGHPMTSTAITVVVQTAVSTDMLLETIKEMNIKVEDMEIKLNKYVGLENKVTHLEATLNGLKSQVDNSKDAITLASANYKGSYYFVTEQRYGNAWEANRLCQLYGGYLVEINDRQEFDFVTDFLYNHTSSLGGLGGAWVGATDEGHEGTWRFMTSGGKVSTLVWHGPEPSGGGGENCMNMRIRSKDMNDYPCFKADAEHFPAIVCEIPHSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8B7</accession>
    <name>A0ABM1A8B7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012933</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942760.1">
        <property type="nucleotide sequence ID" value="XM_013087306.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012933"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012942760.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15306" checksum="127250FA704D032C" modified="2025-10-08" version="1">MRLYCLASAAKHVLKLKLPWCPQKWLLQKEWLTRSDLVKLAETSGSSLEAVLAIDHSVDLQHTYRFRCTFCPRLCDREVKEYRKEDLARQTMRAHLLDHIKNFAATVPQEDQEDFLTRNQMWREKKTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8F2</accession>
    <name>A0ABM1A8F2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxypeptidase O</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106012947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942818.1">
        <property type="nucleotide sequence ID" value="XM_013087364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012947"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF140">
        <property type="entry name" value="FI02848P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012942818.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11519" checksum="719E1E55FD57A815" modified="2025-10-08" version="1">MWRKNRRYIRPTCTGVDLNRNFDSRFGTVGVSSNCGSDIYPGERAFTEPETANMRELVYSLQGELVSYLSVHSYSQFLLVPWGNVEYVSRPTNSMELDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9T0</accession>
    <name>A0ABM1A9T0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101852275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_012943563.1">
        <property type="nucleotide sequence ID" value="XM_013088109.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852275"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012943563.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="51793" checksum="DB50351A3544DF64" modified="2025-10-08" version="1">MFIKRCVDCFRPRFSRFTLVSLCAVGLLVLLSTFPRTLLMNAGNYRPDVSIDTTVTPNPRAEVRTDMKGNPTSSLTFLSDARRAINSVQKYVISKLHNSSLRLQHINSTPASRSKHTTDRSLNTPTQTTLPTTSQDAGEDFTTFTDDDVLGSDNSSRSTGVDDVSNMTSTARRGRKVVNPHDFRYIHQSADVCRGREVELVLGAPTSADNFRGRKTIRETWGQYAKNPEHRTALLFFLGRPRTKFFQTRIDQESETFGDIVQEDFLDTYRNLSLKSVALMKWVSESCPNSTFVLKADDDMYINVPRLLKDLRAQYQRTRTFIMGQSHARSAVIRDKKNKWYVALSHYPGRYFPHYMSGCAYSLTTSAAKRIYQESLYVPDFFLEDVYLTGMLAQRTSVPLINNWKFNGQKIAPNGCNYQKRISGHKNSMDEIRKIHKELQDPNIVCYFQNGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9X8</accession>
    <name>A0ABM1A9X8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106013173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943650.1">
        <property type="nucleotide sequence ID" value="XM_013088196.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013173"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="670"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943650.1"/>
        </source>
    </evidence>
    <sequence length="907" mass="100643" checksum="E79214BF0EBCE853" modified="2025-10-08" version="1">MNKHTLNYHTRLHDWYRQHSIQQEKQQQQQSLQQELGGGLGHGGVHASTHSLAVVAPACGTSADHAAAGAHLSQDKLYFISQWCSEVNKTLFRVKRKESPPLYRRCRLGGASSKDLTASGVGLSGGKSTADPRRVRSAEVFTLAGHWSKQPKPTLSGGELLPTSSQVKIGGGRGGDYNKRDPANHVGDSRGVDLCVRNSKDKDCQHEPPMARINHDSLNVRSNAFILRHQYNNGRYSRPGGAGLVNAVLSPRSSATQLEKLDKEQRGLLYNNDLPSARRRAKSAAMHSTRRRLHGMDEEQDEEEEEEGERDYSRTNGAAKSGEESHSSHKELERLNNAKNEEDSLRQQNLRPVSSSHKSRVASSKTKASSMSDLYEEGEDGNSTLVRKIINVVVTDEANVNPQLCNDCNQNLADKAAKEAAENEETVRKILNEELERTKRLAETEKQIDQEITKAEVNVKHVTNRLTEDSLHYSSEREALRLVNANKSFTIPNNFDDLEDERNISFEDINGDEDKMSEEVSDDAHSDINSDASSPIKVTAARRKSLVRIKIENVDDENNASKEESNTENQQPAVVKDSRSLSVSESDQMEAPDVEMLKIIQERRGSRRKSLSFGIKPTVGNLSTSNSLLHVLSIDDCKMSMRYSPHKILEEHEVTDSLMLPLSQILTSEYLNSSPENSPRETGKGNKYNDNNNNNNGVVDSARAYGSKAAMRVSGQDSGMTTLRTASAHHATKTNKMQYRILTDPNDPGYYKNMRPQSACLAKAFNTLINDRTIMQRLGDRPGTASNANNGRNRIRSASTKSLTASATGSKPAYEGPVYQRANTVLKKQMEALLQRHSSQMKARYERLKNNPTPHKKPLVLTLGVPSLNEEVSEKSLSLESLPLVKKGILKDSRESLLKGSSESLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA95</accession>
    <name>A0ABM1AA95_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ral guanine nucleotide dissociation stimulator-like 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943845.1">
        <property type="nucleotide sequence ID" value="XM_013088391.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852575"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00153">
        <property type="entry name" value="RA_RalGDS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF312">
        <property type="entry name" value="RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="60"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="225"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="624"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="534"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943845.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="82871" checksum="C4EDA9E317EECEFA" modified="2025-10-08" version="1">METTSTEQQDDASRFWREEKETGAVYNAFLKKVTYLSQTRLEDENEKNSEFSHLMWETHKVRVIKAGTLEKLVESLTNTRGEMDSSHVNIFLATYRTFATPQQVLETLIERYVQLRSQTKEEKTEFHEQQLRSLKSVIFVWLDSYPEDFHVGPEYTCLHRLEQFAHDYAPGSGIGRKVKEVLAGFRQQDVELAAKQLEYSFSLSEGNGHPVDTDSSKSLALLEISCRKIAEQLTCRDAGLFLRVIPHHCLGAVWSRRDKQGTATDAPSIQATIQQFNNVSLRVIATLLKTRELKSSQRAKVLQKWITIAQDLRELKNFSSLKAIITGLQSHAVYRLRKTWSALSKDSMVLFEELSEIFSVENNQLNSRELLMKEATAKFPDLDSQSKSLKRKNLQKRRSWIDNGIVQGTVPYLGTFLTDLTMIDSACPDTTEEGLINFEKRRKEFEVIAQIKLLQVAASIYNISEDERFWRWFNSIRTYSDTESHELSCSLEPPSESSAKIKKKSASLNGPPFRRRVSAAKLYACFACKSRFSEPNISRSPKSPAAPPYEPPPAECLGNKPSKIDNSKLGLFSCGSEDRNSIASIPDTIAASIGPLLSHSSSTSSVISSDSDTPSTHTPFKSSDSYVIKVSMETGQNDTTHVYKSIMLMNSDHTQVVIEKILEKYGVDGRPDQFCLLQLLPDGELLIPERANVFYALNNSVDLKFILRSRRDYDQGKDKRKTGRRSGKKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAS5</accession>
    <name>A0ABM1AAS5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ataxin-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944130.1">
        <property type="nucleotide sequence ID" value="XM_013088676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013311"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944130.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16246" checksum="DA024FF25874372A" modified="2025-10-08" version="1">MADQQQAQQTMQPPVPQAAAPQPHVAQQPQPQQHPPPAPTPSQQQQQQQQQQQLQQSQQQQLQQQLAAAQQQQQQPRVSSVGSIQGVVAPPAPTPQPSLAAANALRSPSTPMPPLQVIGQPMHGQSYLPQFQSYAQPFMLPNPNALGSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABU0</accession>
    <name>A0ABM1ABU0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein fuzzy homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fuzzy family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944707.1">
        <property type="nucleotide sequence ID" value="XM_013089253.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861852"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026069">
        <property type="entry name" value="Fuzzy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13559">
        <property type="entry name" value="INTRACELLULAR TRAFFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13559:SF1">
        <property type="entry name" value="PROTEIN FUZZY HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="168"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="287"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012944707.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45277" checksum="1451F803DFE0FFAE" modified="2025-10-08" version="1">MDGLYLICVTSGSGLPVFTRSVGNVKQLPFPVIGSLNAVHMFAANHEAELKSTATEDARIVWKEFHDSLVLIAVHCGNGRVVDCELERLLDRTWAAMVLLYGLEELRQIRNVERFKREIKVCHPLIDTLLRRVELPVFSDVTGAVEGVLASEATALQNFLEAFVEAADTPYGCLLSHGRLVGATAKWWDLSATELVLLSLLGLSFSPCSCRDVPIYLPDKSPTVPHRLMTFKLMAHVEVWVICGPTPSLSQLEMEIARFWVAAVDTLHQVRQIHPRNFPASIDVDNNILGFILINAATHHSVTSVDVRREGKDSGELRGRREALREFYGSVWDSQMGGPVTEEASTDVKHTITDSYTVYSSHKCYAHICGNYQIFVLFSSKIPTYAMRNVCKKTLDAFVKDKSVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC22</accession>
    <name>A0ABM1AC22_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="3">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101850761</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012944850.1">
        <property type="nucleotide sequence ID" value="XM_013089396.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850761"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="11">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="713"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="713"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="745"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012944850.1"/>
        </source>
    </evidence>
    <sequence length="837" mass="93343" checksum="67B21CBC1CABFEEA" modified="2025-10-08" version="1">MGRKAIVAACSLNQWAMDFLGNMKRIIDSIVEAKAKGARFRTGQELEVSGYSCSDHFFESDTYLHSWEVLGRIISHPSCQDILCDVGMPIMHKNVAYNCRVFFVNKKILLIRPKIMLCNEGNYREPRWFTGWTKLKEVEDHYLPRMIQEHTGQRTVPFGDAVISTYDTCIGAEICEELWNPKSRHIEMALDGVEIIANGSASYHELRKMYIRVDLVRAASMKSGGVYIFCNGVGCDGERCYWDGGSMIAVNGNIVSRGPQFSMDDVTVITATIDLEDVRTFKNSMRSRAEMAAATRQFPRIQADFALSEGENYNLLAESKPMDVIMLPAEEEIRLGPACWLWDYLRRSGQGGYFLPLSGGIDSSSTACVVASMCHLICDAAQAGNKTIISDIQRITTQADYIPSDPRELASRLFMTCYMGSANSSADTRNCAAELADQIGSYHLGIVIDIAVEALLKIFSATFNVVPKFKAHGGSLRENLAMQNVQARVRMVLSYLFAQLSLWARGKSGGLLVLGSANVDESLRGYMTKYDCSSADVNPIGGISKTDLRRFIQHCSQKYRYQALDKIYNAPPTAELEPLEEGRIAQTDEEDMGMTYDELSVYGKLRKQNFCGPYSMFCKLLHISSDECPPDQIADKVKHFFRCYAVNRHKMTVLTPSYHCESYSPDDNRYDQRQFLYNAKWHWQFARIDAEVQKANGSILQLKANAVVPKTEFNGNSSQSATSPQLGSLNLSRQNSSGPPGGVQVQMSSAGSPMVRNSNSPRLVRAGVKEETGVSHVVMSSQPSGPPQTAQYSVVVRDPQKRLTVESPEVLDVDPADKRPRYQLREMVKVESEASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADC3</accession>
    <name>A0ABM1ADC3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101848858</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945519.1">
        <property type="nucleotide sequence ID" value="XM_013090065.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848858"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="Carbohydrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045861352" evidence="2">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945519.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26565" checksum="7C443CF72DF34AF1" modified="2025-10-08" version="1">MRCFVALAVLALAATALANINVPIKNHWNGGFQGEACFIVNVTVHTWAIHLMFDREIQSLDAYVADVSRKLNGGKEYVLTSKSFNQDQHHGDRLCVQFTGHAHGDVVPKVTAKMDKQPQGGSGPSVTASPTRAPVTARPGHTLPPTSAPATVALPTGHGIRAQLQVGTSWDSRFEGQFDFKVTQDIIGWVVKINFNKEVDAMDVSSDFVAHGSLASHCKPFVEIVGKKPVGRQLTLNEMRIFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADV9</accession>
    <name>A0ABM1ADV9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">F-box/LRR-repeat protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101847699</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945812.1">
        <property type="nucleotide sequence ID" value="XM_013090358.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012945813.1">
        <property type="nucleotide sequence ID" value="XM_013090359.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847699"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945813.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54412" checksum="18FAB0E741486F2A" modified="2025-10-08" version="1">MGSTSSSLNENETPSSPPRKRARTSSPNRSLDQCRPYEKETRSQWQVLPYVALTEVYGHLPGRDKFNMALTCKTWREPFSRPALWRRASFRFNDVDDWRALCCVSRVASALRHVTVDCAASDIPADKSVGSADNLAYFFRCLVNAKNCRLTALNVTNMRRLARYLSRPDHDVVTLLTNLLEVQTQLDSLSLRGARLSPDHGLRLLVSAGLSSGSILSLLDVSDLFATTSPRHDMAANPRFLSVLTVFTNLSEIDLNHQYLSDDVMYIFSENLCGKLRKIRVLAHYMGRPERRTSPETWAHLCSRCPDLSADFSVKGVSEYRNACLVLTRATPLTCLGWTSGIHADSLTAMLCTEHIAHHFRGTLQNLTLDVCQSFLDDPEILAKLIERCTCLRKVSVQCGGLSMSAEMRLELAIRRVSKGRVPDAVTPPSAPPTETPPDTPTDTPTAGLEIWLNGRKVDLDKKWPLSLTAVWLMETLEAFTEQWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADZ7</accession>
    <name>A0ABM1ADZ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013784</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945875.1">
        <property type="nucleotide sequence ID" value="XM_013090421.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013784"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046371445" evidence="1">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945875.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11472" checksum="D450AF0EC6A8EDF4" modified="2025-10-08" version="1">MARLVLVCIALLVVVTYQEVTATCDYGSCPDQPADSDDDGYCKKIRDRVTCLENKGKQEDCSGPEKTIIKGLVKAANVLLGATCGVTTVTASLSVCLALATLARIFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE35</accession>
    <name>A0ABM1AE35_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CD109 antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101855617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945936.1">
        <property type="nucleotide sequence ID" value="XM_013090482.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855617"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="7">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="8">
        <location>
            <begin position="665"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012945936.1"/>
        </source>
    </evidence>
    <sequence length="788" mass="87268" checksum="2A9B9F17C59CF34D" modified="2025-10-08" version="1">MEMMMMPPAPPPMAMADFGGPPAPAESASLAEPDRVRTNFVETWLFQTVTTCDSGFATVESTVPDTITSWVASAFAFNSKIELGMAPNQANLRVFRPFFVTLNLPYSVINGEQLALQAIVFNYLNDDAQVRVTLAQSKSFSVLAEEHGLEVLKQEDTVQDVLIKAGEGMSVFFPIVPHELGKIDIEVKAQTTRAADAVRKQLLVEPEGVAKEFNIPVLVELTKETPSFTKIVDLSMPPNVVPGSELMRISAVGDLMGPSIAGLDALLRMPTGCGEQTLLGLAPDVYITDYLSAVNKLHGDIADKALSFMESGYQRELTYKHDDHSFSAFGNNDPSGSMWLTAFVVKVFHQASSHIYVDDNVIIRAINWIINKQNHDGSFPEPGRVIHKNMQGKAGSGTALSLFVFIALLENQDLFKTGSYATKFQSARTNALAYLETQMEHDDDLYNLALASYAFTLAGSSKAQDIITRLNHEATEEDGLKYWHYPETPTTSNPGSWHRPHPTKAIDTEITGYALLTYALCHDLIGGKRIMQWLVQQRNPQGGFVSTQDTVIALNALSEFNRQVYSDNFQVSITTTFNVFQRFRFNIDKTNSLVLQSKDTTRVPSSVKIEARGSGVALVNLAVFFNVLQEVEETFFDLKLSMDDESLNHFSLTVCACWLGEGSASGMAVAEVGVPSGFSVDPDLISDNTLLKRIEVEDRKVILYFDEIGTDDMCLTLTAERSGMVAKCKKAPVVVYDYYEPSNQVTGFYEPKLLKDSKLCDVCKECKGCQDRLQDKRVEFLDFELERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG17</accession>
    <name>A0ABM1AG17_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospholipase A and acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106014223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946933.1">
        <property type="nucleotide sequence ID" value="XM_013091479.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014223"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="6">
        <location>
            <begin position="52"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012946933.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19257" checksum="56DC128C3AD18922" modified="2025-10-08" version="1">MSFFSGSSSLSSASSSSRSAAVFSSLPAATPPSKEDKAHNLKVLKSLSPGDRVEFKRGVFSHWGLYIGDEKIIHVTGPEPEQAEVRIDKFLDVVQDGRAEKNNSKDEEWNPLAVGEIIKRAKQRLGKVQYSLLSNNCEHFVNWCRYGKSESDQVNKVMNTLFFPLPYSSLTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQF1</accession>
    <name>A0ABM1VQF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Kelch-like protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101856875</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094378.1">
        <property type="nucleotide sequence ID" value="XM_005094321.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824643.1">
        <property type="nucleotide sequence ID" value="XM_035968750.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856875"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF441">
        <property type="entry name" value="KELCH-LIKE PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035824643.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="62481" checksum="1E3A63807410FF4F" modified="2025-10-08" version="1">MESKDFVTSFHAKLHQLWADSELCDVQLCVEEMVIPAHRIILAALSPYFKAMFCSHLNERQEFQIRIQGLNAQAVKAVVQFAYTADLCLSEETVQSVMQTASMMQISAIEKLCCTFLLEHMYPENCLGIRDFAHVMGCFELKEAADKYCEDHFFDVSQSEEFFQLNVDEVIGLISRDGLRVAKEEEVYAAVMRWVEFDPERSKQDIVRIMEHVRLPLVQWDFLTKKISRDELFVSNEECRNYLQQARAFQASSYHPDLINFAFNEAVPRSHPRAFFSAADRLYSIGGESSSREILSSFESFSPYTNEAKELPPLPEAKRSLGVAILDKIIYAFGGASGFQGSRTVHAFDIDKQEWQVKSPMCEVRSSLVAAVACGNILALGGHGENSVLTSAEKYNVEFNSWTFIPELLEPRSMAAVVVIESSLYLCGGYNGLEDLRSCHVLDTKIWQWSVCPSMNERRSMHGAAVLDGNIYVAGGLGHNTCLSSAEVFHVSTQQWTVVQALPGARRGFGLTVIGDTLYAAGGHDGTSVQGSILKYNKSTGDWASIGHLITKRGRFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQT1</accession>
    <name>A0ABM1VQT1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858334</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824773.1">
        <property type="nucleotide sequence ID" value="XM_035968880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858334"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824773.1"/>
        </source>
    </evidence>
    <sequence length="588" mass="64990" checksum="89E08A777796BB88" modified="2025-10-08" version="1">MVKSAGFHQDSIPLKDVEAGNVHYELPGRSQADKKLLSKDGGTSNDSSDNSRDKWGRKAEYVLSMIGYCVGLGNVWRFPYVCIRNGGGAFLIPFFICLTLCGLPLYLMEVAMAQFVGLGPFHVWSICPMFKGIGIAMNSASFFLSWYYSMILAWSLIYLVNSFRSPLPWTQCGQSWNTANCRTPHEMKTGLNGNTTLQELASNLTEYSLTSRNGTPSLDTLPQNVPDLMVSDSYNSTYSLENDTLLNSVASSVGNTSVSSSEEFWINNVLHLSSGLSEFGTIPWESGVALVVQAVIVYLCVIKGVSSVGKVVYVTATLPYILLTVLLIKGATLPGALDGVIFYLKPDFSKLVRVQTWVEASLQVFYSLGPAWGGLITMASYNKFNNNCLRDSVLLSFACEGSSVFAGFAIFTMLGHMAHTLRVPISTFANTGPGLVFVVYPEAISYLPLPQLWGVLFFIMLFTLGLDTQFVMCETLLTTLGDLFPGLMRKRQALIKLLYFAALLLISLPFATEGGMYLFQLVDWYFAAYAVIVNGILELVVVGWIYGAERFFDDIKLMLGRRPPRLFIIVWRFITPILLLVSHQISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSQ9</accession>
    <name>A0ABM1VSQ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Transmembrane protein 127</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101849842</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097510.1">
        <property type="nucleotide sequence ID" value="XM_005097453.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825451.1">
        <property type="nucleotide sequence ID" value="XM_035969558.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849842"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033331">
        <property type="entry name" value="TMEM127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046795">
        <property type="entry name" value="TMEM127_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28358">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28358:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20517">
        <property type="entry name" value="TMEM127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 127 transmembrane region" evidence="3">
        <location>
            <begin position="177"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005097510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035825451.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37433" checksum="4C0A593D9309E9C2" modified="2025-10-08" version="1">MSQSESPDPPENQEEDTPGHSATSLPHSSLPPPVVDPGSSHPRRSGSGGRARSSRRGHSHRSRSANGRSRSRHRHSSNRRHSRHRCRTYFQHKERNFASASCSMVTIVLLCTSLEPNWIYMSGGDCHLLHDPKGSLHTLSTRQFFSNGHFYKNYPLTSAGDMVYKFGGSSNDILVNCVTYTAVLLFKASIAFTLIAVVFSFISFLLDLFGPTYQLLKLLRRNAIFNILTVVMCISINLFAYWITSAVERLQESSRMHLGSKVEVTFAASFYLITAAGGMSVLATACNCLRRHKGVEAEHVRQADRYFDDTEALLPPPPPEEDSSPLSNLPPPPPYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT18</accession>
    <name>A0ABM1VT18_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCY1-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825560.1">
        <property type="nucleotide sequence ID" value="XM_035969667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858105"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="844"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="881"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035825560.1"/>
        </source>
    </evidence>
    <sequence length="944" mass="102532" checksum="48E71FCDD39FF258" modified="2025-10-08" version="1">MDVLHRLKSAVTNVLPGNPLSRDFDIQAQVASAGPRLLWKVFSAVKKSTKEEASVFLFEKKSLERFQKRDREVIVDGLRRGVQQLTKLRHPRILSVIQPLEETREALAFATEPVFASLANVLGSLDNIGSPPQFLTDFELYEVEIKHGLLQVLEGLWFLHQDAKMLHRNVCPTSVLLAKTGTWKLAGCEFVLQASDTQEQNPVYRFEEWRSDVPPEAQPNLDYLAPECELTQRVSPSSDMFSFGVLMYALFNKGRTLYQSHGELTTHRRNLQELSGLRSSQLSNIPPGLVDHVKLLLNTEPTLRPDAAQMTKVPFFEDMACVALQYIDSLYQRENMEKANFFKGLPKVIDRLPKVGPQQRILPALFKEGINANMVPFVLPSVFLIAEQSSTEEYRALILPGIIPFLKLREPIQVILMFLQNMNLLLSKTPTQQLQTYVFPLIFSALESDSPQIQELCLNIIPTFADLIEYNTLKKSLVPRVKKLCLSTSVLNVRVNSLLCIGKLMDQMDKWYVLDEVLPFLRDIPTREPAVLMSILGIHKVALSEAKLGITKDVMANKVLPFLIPLSIDNNLNLSQFNAYMSVIKEMLSKVDAEHRGKLEQLDQMQQDHNGMVCLHRTLEISKITGENGSAKQQTDGKSSFMDKFLTGVGLGGSVNQTSATSPVGGASSPDSTPRPAHTTANATVTKESSLTPKKTGLTLEEKQRLAKQQEQERTLKSQRPLQPLNSSTTSPAAPVNGSLSSSSFSSSKSSSSSSSSSSARNGPRDLTSTLMESNMRNLSVASKSSPAPGATSCSPSTTPLGMMVSSGFSGGMAGGRTGGGGPVNWQGGGGVGGGGGAIPLMNSSSSVNWGSSPSPSSSHSSPFAPPMSSMPSSSSSLSSGQGKSQIDMSSFDSLLTTPGVGANRTPPMNQMGGPGGLGVTGGQPARQMTGTVDDADVFPCWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT56</accession>
    <name>A0ABM1VT56_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Acid-sensing ion channel 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101862647</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825598.1">
        <property type="nucleotide sequence ID" value="XM_035969705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862647"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035825598.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44478" checksum="466B24F9598F600A" modified="2025-10-08" version="1">MNNTAHHNSFEPRPFNTQYDNNIPESISMKPYAKDGVTSSSLDPDVISPQKKKGSLTWKEALFDFTQNTTLHGIRFIFMNDVFILRRLLWLALFLTCSVLMSVQIVERIVFFYSYPVTVNVHVNFNKTLAFPAFTVCNQNAFRASAATDRHLYRLIERLHSGDTSALLSQSPDPLPSNLSLDELYLTTAHRKEDLIVRCEWQNKPCGPENFTLVLTDHGVCYNFNDNPSEPLWVTSTGAEYGLKLTLNVEQYEYMPGPHDAAGIKILLHDGKEFPKVAELGLSIPTGTHTYVGIQLLKIQNLPAPHGTCRSERSPYYERYSPDACQLACLTKYVSEQCHCRHFYMPHIDGSPPVCTLGEYLSCYERIIDQVKDRVRAECDCPVPCDFLIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTQ1</accession>
    <name>A0ABM1VTQ1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101862873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035825793.1">
        <property type="nucleotide sequence ID" value="XM_035969900.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862873"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045006845" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="35"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035825793.1"/>
        </source>
    </evidence>
    <sequence length="571" mass="62079" checksum="6A8F74A6EB67B833" modified="2025-10-08" version="1">MASAWLLQALFTTVLSNEILQARQAGTHDKFLLANTTSGTLRGRVDSGLPVPVARFAGIPYAKAPTGPLRFKAPASPDKWTGVRDALVFGDECLQRVAANDAFRDPNAPHSEDCLYLNVYTPTKRTSSAPLPVMVFIHGGGYNSGSGSSYDASYVASKGVVFVTINYRLDLFGFLSTEDDIMPGNYGMLDQVAALKWVKNNIASFGGDPNLVTIVGQSAGSASVSLLTLSPLAKGLFHRAIMESGSALSPWAVEYPGNRMTHRIAARLISNAVNCNDLNNSSALLSCLQKVDANTLLKASLGITRAVQATLINVPRVETTFGFLPDKPTALLSRGQFSHVDTLRGFNSDEFGGIIPALAGPQPVTREVAKQIWRGQLAQFTDIDREKVLKSMEATFLTGKTTTDAIQRGTLDGVDYFVFGAPMVSELEKVVSKAPEKKHYLYQFNYRPSFSKAPQWMSALHGQEMIFWFDAQIKLITDKGNGIPTLNDRLVSLEIMGRWTNFAKTGNPTSTIPNAQATWNQYRSGAPNYLLINSASEAKRLYSPRVATDFYRKVLDSLQGPSSNSITPIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUA0</accession>
    <name>A0ABM1VUA0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477785</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825992.1">
        <property type="nucleotide sequence ID" value="XM_035970099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477785"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035825992.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14134" checksum="B2E95B7E0A6209C9" modified="2025-10-08" version="1">MDQTEYILFQEMYSGRASSHVGPYKRKEYILCQEICCGRESSPVGAAESKGCSALLPSYHHPGKGPALEYPNRGVSYGPDRVHPVSRGVFWKSVESCRTIQEKRIHLVSRDLLWKRIESCRSSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VV98</accession>
    <name>A0ABM1VV98_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826340.1">
        <property type="nucleotide sequence ID" value="XM_035970447.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854507"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051720">
        <property type="entry name" value="rRNA_MeTrfase/Polyamine_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290:SF0">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="3">
        <location>
            <begin position="79"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826340.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27502" checksum="A9F5E606F94D7205" modified="2025-10-08" version="1">MNTSLYCHPHSTVNFMLVPRLRYSIIMAAARKPMRLKELEGYLQDVEVFENPKVKLEQYPTTPHIAACMLHTITSTYDDLVDKTVADLGVGCGVLSVGASMLGSGYVLGIDIDEDALATCSANLDEFEMTNIDLLECDVKSLASSEVVNRLHGKFDTVIMNPPFGTKHNQGIDMVFLQAGLKLSTNSVYSLHKTSTREHILKKASDWGVDVTVIAQLRYDLANTLKFHKKKAVDIEVDFYRFSHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXA8</accession>
    <name>A0ABM1VXA8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827051.1">
        <property type="nucleotide sequence ID" value="XM_035971158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012486"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827051.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19971" checksum="21932FC887144B62" modified="2025-10-08" version="1">MFVCSPQACTLEQSKAFLDRLVRVSELQLLQYDALMVIDDVEKGRVEPTRYPTSELIRRKNAGEPLEDEEDKDALPRGKANWIGVPSNQFVVEGRPSKLQVTPTIPTRKTTLAHSATVKARDKAYLDYKEQFENMLQQIEKEKERLLISEQRWEESWEKSVEKVKDLYQKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYC3</accession>
    <name>A0ABM1VYC3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC101855040</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005105145.1">
        <property type="nucleotide sequence ID" value="XM_005105088.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941737.1">
        <property type="nucleotide sequence ID" value="XM_013086283.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827416.1">
        <property type="nucleotide sequence ID" value="XM_035971523.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855040"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005105145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012941737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035827416.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44235" checksum="D386A7B220F094C7" modified="2025-10-08" version="1">MAKSGKTIQKVDTVVNADSVEWCPYHDNQHILLCGTYKLQESQSSLLEAESEPPSPAQVDKDVENVSRDPEVQVRVGGVTVYSLNFEGNTPELRETSSAALCGILDIKWLNEEVEDKALFGLVDAEGYFQLLQLDQESKRPSSITKEQLSDSSLGLSLGWSPACSGGTSRVAASDSAGCLTVFDVDSKVNTISSWQAHGYEAWITAFHKTDKNILYSGGDDCRLKRWDLRDTTQPTFTSRRHQMGVCSIQSHPFKDYIFATGSYDEELIIWDDRQLKKPLSYAALGGGVWRIKWDPFQGDFILTATMYNGTHIIDCTDLGQTPLPVVAKYDDHNLAYGADWCRLSENGTQRPARTQNDDQCEDIEKDKAPDDDTYLISTCSFYDHALHLWEWQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZR3</accession>
    <name>A0ABM1VZR3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Uncharacterized protein LOC101856210 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4" type="primary">LOC101856210</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106883.1">
        <property type="nucleotide sequence ID" value="XM_005106826.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827906.1">
        <property type="nucleotide sequence ID" value="XM_035972013.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827907.1">
        <property type="nucleotide sequence ID" value="XM_035972014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856210"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005106883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827907.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11733" checksum="096AB810F81122B4" modified="2025-10-08" version="1">MDRLYRECQETRRDKMMISIRRIAHSTTPVDCGQDQRIVLIDCVEKQETLNDQPQKITATLQTFGQEDTGVISKSTTKSQRTNSWQCLFDPLSIHFTASLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W126</accession>
    <name>A0ABM1W126_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable vesicular glutamate transporter eat-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828369.1">
        <property type="nucleotide sequence ID" value="XM_035972476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853645"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828369.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31746" checksum="EC0C41A58C82EF86" modified="2025-10-08" version="1">MSLTAYSLPSECPHLEERELCHYDPDQAKVQSGSDQLARHIPWRRILLSKPVWAIWLGTFNKYWVVSVMTTLQPQFFNDIYGLRAADIGFLLSAQPLVNSVFVMLGGILADKLMYDKILSATGTRKMLQALGGYLEGLSLIAVAFTSDWRYSYAFFLSAYAFGGLSVNGYKVNRVDLSSQYANIVAGISLTGSSGGAVSTLIASMILGDRSISSWRTIVIVAGSMSFACSTAYMFMGSGERQAWDIERPPSKSVKDKGKSGDHKTDKDEDFSVKNCLLEESDLSDSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1L6</accession>
    <name>A0ABM1W1L6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC100533284</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035828559.1">
        <property type="nucleotide sequence ID" value="XM_035972666.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100533284"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20794">
        <property type="entry name" value="C1_aPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06404">
        <property type="entry name" value="PB1_aPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05588">
        <property type="entry name" value="STKc_aPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034659">
        <property type="entry name" value="Atypical_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034877">
        <property type="entry name" value="PB1_aPKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012233">
        <property type="entry name" value="PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000554">
        <property type="entry name" value="PKC_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="19">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="268"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="537"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035828559.1"/>
        </source>
    </evidence>
    <sequence length="610" mass="69977" checksum="2A64BB6973A0BFB9" modified="2025-10-08" version="1">MPTLEVDELDNSVRIKVGYNGNILVTNIKNDVKYPDFCAEIKDICKFDDVQPFTVKWLDEEGDPCTISSQIELNEAIRLYEVNKDSELNIHIFPNVPARPGLPCAGEDRNMYRRGARRWRKLYRVNGHLFQAKRFSRKAACAFCSDRIWGLGRQGFKCINCRVTVHKRCHKLYKKQCGGAEDIPEVGASPQNGEKGAFGDSRSNGDSKGGRSHQNLPVEYGKEEMKVEQYREEDDEEEDHFVDAESFMTAKVEGSSTKDGNQLNLDHFQLLRVIGRGSYAKVLQVEHKKTKRIYAMKVIKKELVNDDEDIDWVQTEKHVFEAATNYPFLVGLHSCFQTSSRLFFVIEFVNGGDLMFHMQRQRKLPEEHARFYAAEICLALNFLHERGIVYRDLKLDNVLLDAEGHIKLTDYGMCKENLMPGDKTNTFCGTPNYIAPEVLRGEDYDFSVDWWALGVLMYEMLAGRSPFDAVGNADNPDQNTEDYLFQIILEKPIRIPRSLSVKAASLLKGFLNKAPAERLGCHPATGFSDIQSHPFYRSINWEMLEQKQIVPPYKPYIRHERDLEHFDPAFTNEPVRLTPDDPSAINEIDQSEFDGFEYVNPLLMSMEDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1S2</accession>
    <name>A0ABM1W1S2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiopurine S-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118478672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828615.1">
        <property type="nucleotide sequence ID" value="XM_035972722.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478672"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259:SF11">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828615.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14705" checksum="3A3340DD9B330895" modified="2025-10-08" version="1">MSKEGESSDGRMGVWLDMWDNGGMSEFQVNKPHPKIQEHYEFYTSGNPDATLFFPLCGDMHDMVVLGGKGHTIVGVECSETGIKTFFNKNKIEFTEEKCDAVKGKCFKSKDGRYRMYSCDIFDFNKSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4P0</accession>
    <name>A0ABM1W4P0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101852598</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829633.1">
        <property type="nucleotide sequence ID" value="XM_035973740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852598"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="203"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="409"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="615"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="821"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829633.1"/>
        </source>
    </evidence>
    <sequence length="1146" mass="125777" checksum="E5DA45765B1368AA" modified="2025-10-08" version="1">MNVDVVSLMPNRLMTASSDQGTGTLPSDGRMQNPVNSWQPDDNDKNPWHQVDFQTAQNLSGILTQGSPSSEKWVYTFTVSTSNDGINFETIKDDQGQEVTYYGNTDRNTLARNYFPRVTVARYVRVSPKTWAAGGPALRVNYIGCFFSDVSTPRPTVPFVQPPTGPTGIPTVSSTWPSSWSSIPTSPTVAPPTPFTLVPNVICNVPMNVDVVSLMPNRLMTASSDQGTGTLPSDGRMQNPVYSWQPDDNDKNPWHQVDFQTAQNLSGILTQGSPSSEKWVYTFTVSTSNDGINFETIKDDQGQEVTYYGNTDRNTLARNYFPRVTVARYVRVSPKTWAAGGPALRVNYIGCFFSDVSTPRPTVPFVQPPTGPTGIPTVSSTWPSSWSSIPTSPTVAPPTPFTLVPNVICNVPMNVDVVSLMPNRLMTASSDQGTGTLPSDGRMQNPVYSWQPDENDKNPWHQVDFQTAQNLSGILTQGSPSSEKWVYTFTVSTSNDGINFETIKDDQGQEVTYYGNTDRNTLARNYFPRVTVARYVRVNPKTWAAGGPALRVNYIGCFFSDVSTPRPTVSFVQPPTGPTGIPTVSSTWPSSWSSIPTSPTVAPPTPFTLVPNVICNVPMNVDVVSLMPNRLLTASSDQGTGTLPSDGRMQNPVYSWQPDDNDKNPWHQVDFQTAQNLSGILTQGSPSSEKWVYTFTVSTSNDGINFETIKDDQGQEVTYYGNTDRNTMARNYFPRVTVARYVRVNPKTWAAGGPALRVNYIGCFFSDVSTPRPTVPFVQPPTGPTGIPTVSSTWPSSWSSIPTSPTVAPPTPFTLVPNVICNVPMNVDVVSLMPNRLLTASSDQGTGTLPSDGRMQNPVYSWQPDDNDKNPWHQVDFQTAQNLSGILTQGSPSSEKWVYTFTVSTSNDGINFETIKDDQGQEVTYYGNTDRNTLARNYFPRVTVARYVRVNPKTWAAGGPALRVNYIGCFFSDVSTPRPTVPFVQPPTGPTGIPTVSSTWPSSWSSIPTSPTVAPPTPFTLVPNVICNVPMNVDVVSLMPNRLLTASSDQGTGTLPSDGRMQNPVYSWQPDDNDKNPWHQVDFQTAQNLSGILTQGSPSSEKWVYTFTVSTSNDGINFETIKDDQGQEVTYYGNTDRNTLARNYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAB4</accession>
    <name>A0ABM0JAB4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat-containing protein 93 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089077.1">
        <property type="nucleotide sequence ID" value="XM_005089020.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861474"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049547">
        <property type="entry name" value="WDR93_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF17">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21030">
        <property type="entry name" value="WDR93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005089077.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="81137" checksum="1A0E7D12321A6EEF" modified="2025-10-08" version="1">MPVYIRKNVSYTPPSIYNIQLEDDNDYLLDPDQLRDILPQPYRMINKILVQLLDNVWEIVEGKENTILAEARKVRPPRLEEPEELPVFNNATALKESVDGKYIFVGLPNGLAVMETQTQTQLHAWEEEHAEITDIKTYLISPDWHLIVTVDDMAISRLFLFAFNHIFFVKALNENSPEATSKILCQKCEASKDGDYAGLVLENTGSKEVWFEVHKLPVEGWQKELESIAAAISKQKEENEKILAENVEDPPEQVEGQPPPEQPPQQESPRAPVPESTVIEQLGVKFSQPSVILKVKPPHKLPLPPNGSSSVASAISKVDTGDVLGVGTNHVLSSAHLESRDVMFKHRHDSMLKYLPEEKEDFTLSATFHFVNVSRMLTFGLENNTPEFRPVAVMVWWSGSPHLSQYSLLKAAGKDIEFKADIVWPFTSNITCSAVSPCTTHLALGLENGNLVLWDRQLGLDKAVLTVSDKSALRSVRFLDPCLFPMDQPHYPPYPVSSATFLLTECCDGSQALFDTCDGSQQIPRCIATEPENDDDIQTLLKVIPELPELIIYVQKNGSLYIKDIGTGAALCQVVLPPTHSLQSPWEPIFALGGGGNFLFVKAEGTEETEEGEANDISCLFMYNLKSYRELEPYWSREHQKKDLAVYTDLDSRISSLMQERLQQQALRKPHMQNRWGQLRSELSMIQQAHAVPLDSLRITAPSSIHSSHEEIHFKTTKASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAJ1</accession>
    <name>A0ABM0JAJ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089199.1">
        <property type="nucleotide sequence ID" value="XM_005089142.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848929"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07401">
        <property type="entry name" value="MPP_TMEM62_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041871">
        <property type="entry name" value="MPP_TMEM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056230">
        <property type="entry name" value="TMEM62_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24394">
        <property type="entry name" value="TMEM62_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046608527" evidence="2">
        <location>
            <begin position="17"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="4">
        <location>
            <begin position="321"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 C-terminal" evidence="5">
        <location>
            <begin position="454"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005089199.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="74195" checksum="A3259180413383DE" modified="2025-10-08" version="1">MMKWLVFLVGVGIAMAVVLSSILSALDPNSAPEVSHEYKRQPRLKKDWPSMDGSNKKLFWIVQISDIHISAYYDPSRGPDLEKFCKEYLPVIDPKLVVATGDLTDAKLVNNIESKQMESEWILYSNIVKRCRTLAKAEWLDVRGNHDSFDVFNFDSENNYYRFYSAHGPALSKDHHFERAYYHTLNLPFGSYSFVGFDACSKPGPNRPFNFFGYLDDSQVQHLRGLELSTRKSNHTVWFGHFPTSLIVHDPPVLRSIMRRSIAYLCGHLHTLGDTVPQMYSKHKTGQLELELGDWKENRKFRVMAFDHDLMSFTDAQLGDWPLVVVLNPKDSQFLSAENEPVELIERSSHVKVLVFSPDPVSVVEVTVDGRLLGEASQEDGPLYTLAWTPQQYAHGLHDLRVVVKDARGRTKRVEQTFSLDGSQMPFKFLPRLLLMLNLYSVGKLIYGLMAFLFTLILTSLRQCSNIRTFYFQGRNFICQFLNSWLMKMWLAARTNPSYYIVTGSVLYLTFGPWFVGDLLRGRTGLVFVWGMIVQGAFIPGGITYFYGIFQLLSFSLPLVTLLGHLLDTRRKHGNRVTARHVFTIFLPFILLLFLTLYIGFKEFPSAYGMYALLFGPLRTGNIFLLVLSVYLCYKTELKHVLAINGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBM8</accession>
    <name>A0ABM0JBM8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101850922</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101850922</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089948.1">
        <property type="nucleotide sequence ID" value="XM_005089891.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089949.1">
        <property type="nucleotide sequence ID" value="XM_005089892.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850922"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005089949.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="53583" checksum="0176C8A2290227DD" modified="2025-10-08" version="1">MSGDHLPQNTIPVKQEDLAHSPKAQDSVTSQTVKLSAPPELRLKRKCLKAANGTGEGSTEAQKDCNTNIERPQAHEPKTKSFQSHVDIKVHDSRSPMAFRPNHAVHKKVTMNRGRNCDKLMERLRNGKKTRMRLSYEVDVEYVTEGTCSDSESSDDHENGASRKLKPVIAWSFCREGDTTPLFTVASEVCISPTEEEPGASEDSKPDKDTTDGSQMENETCTAKSFDNVRDNNWSMIDLHDMKNVTLRTYRVRRQSDGSVRRELGPALASKVWISEGNRKTLTPGPVHHSSSCGGKSMTDKQHPGVPPNQTRSSITSKENQKKDEASSKVKKFFSWLPLKEKLAQSFKNSQFFKNQQCNDSHNECRPKISKTAKPCKAIKSFNLHTRAQVSETGSPVKISTRYPMTTSAELRLCTASRKLLPPTCPCDDKKSQNCEHNDEAQQTPKQLTNVIPKATPGVETNGQEKKQLWTTHRRAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC20</accession>
    <name>A0ABM0JC20_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C-terminal-binding protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101849741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090206.1">
        <property type="nucleotide sequence ID" value="XM_005090149.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849741"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="39"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="135"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005090206.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="47116" checksum="BB9FCA2F492E0288" modified="2025-10-08" version="1">MQAPKKARLEPSTMSIRGPIPNGPMHPRPLVALLDGRDCAIEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMWHTITLTKEDLDKFKSLRVIIRIGSGYDNVDVKAAGEMGIAVCNVPGYGVEEVADSTMCLILNLYRRTYWLANMVREGKKVNGPEQLRDAAQGSARIRGDTLGIVGLGRVGTAVAIRAKVFGFNVIFYDPYLADGLEKSLGITRVYTLQELLFQSDCVSLHCNLNEHNHHLINDYTIKQMRPGAFLINTARGGLVDEHALAAAVKDGRIRAAALDVQENEPLVYANSPLKDCPNLICTPHSAFYSEQSVTELREMAAGEVRRAILGRIPDNLRNCVNKEYFTPTTSSVRYPFPPAGPFADSINGAAGYPAFNPAVAAVAIHSTTDHPAVSHGGAILTTAHTAPDSGNHVPKPENPSPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCB2</accession>
    <name>A0ABM0JCB2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101850222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005090387.1">
        <property type="nucleotide sequence ID" value="XM_005090330.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850222"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07855">
        <property type="entry name" value="STKc_ERK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="55"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="852"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="952"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1129"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="674"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="854"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="900"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="961"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1132"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1224"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005090387.1"/>
        </source>
    </evidence>
    <sequence length="1360" mass="147992" checksum="E34EAB4A2B6A0192" modified="2025-10-08" version="1">MSANTVKKDGDKVKATLNPGKTTSKSSKASDLDKIRQSLAKRSLNVKFDLQGSDYKPIENIGIGAYGVVCSAIHTKSGDRVAIKKIPSVFDALIIAKRTYREIKILKHFKHDNIICIREILMPKENVKAYQDIYVVFDLMESDLHRIIYSDQELSEEHIRYFLYQILRGLKYIHSANVVHRDLKPSNVLVNEDCHLRIGDFGMARGIFYTPDEPSYYMTQYVATRWYRAPEILLSMLEYGTAVDMWSVGCIFAEMIGRKHLFPGKDYMSQVKLILGVLGTPSEAVMKNCQNDILKRIIKSFGKKEPMAWDKLFPKASKKSIDLLSKMLVLNPEVRIPVEKALSHRLLNNYHDPDDEPICVPTFNFDFEKEEMDKPSLREAIMHEITDFHQPRQPSLSFSAFLRPAPKLEKSEDKHEDVIVSSDSPTSQPKGASKADSVTETRASGSYQTQKTPNADTHKTGSKVSPVSLDVGRLQVVAPSADIEMLSAQSNDGRAMETQGPPELPPVKKKDVGPDGKVSEGQKAAPGEKESTGKSVTPEKPSNTISEDTKALVKQALLNATQRRQRAESQSDDVDRSKPITAQQRQKEREEKRRKKKERALEKVKKSKDKKGVQEQSISLSNQDVELLRRWTVMQNPAQRGQHSNSNSPPHPEPSSSPANHSGTNNAPGGASTGSGALQGSKQSSGTSSVKPRQILAKTSSSTLTMASSVTLSSNQMNSGGTVIISSSQIGLSQSNFIPVIAIPSAVNPGKLEIKRIYRSEEVTPQAGMSGGNTSSFSSSQASDSTKAMLQNAILLRSQAEAGAGNSNQRSDPVKPLGSFLHQIDTKEKVSSVNSSGAPSFPFLHQIDTKEEVSSVNSSGAPSFPSQATSKGLPEVSQLSAIPSHMLPASSTGAGSSSHLHSEPQQDVSSEEKFTPNGQGNDLSDFLDRHIKEEAENMEKLGGKSFGASSFDPYSHHMSGDGQTNIFKSENESPSSENLQINLSPPHPPPSYSSFPQVLQPPQQHGTGAHLPQGTGESHGRPNHSGDASHNTDALPFSVYGDQLLSNSFPTHGSYGGNFHQANNSTNNTFNNHPPNFLTGENFSEYPSRGADLNFAGSDPHPQSNMLFPSTSEFSPQASQIQQQRHQHHQQMFPSTSSSFQTPQNFGGSGPSFQIPSSSSVALGPCASNFNNNNSYHQQRQTHQHNIPMSAGNPVSSSLGNSGGQQAQLFHHQPHGHMVGPSASYGNQHQPLPGPSNVSRGLTVNCNKPGRTADSPADLIALLSKQFSKSQVVDVFPPTLALTPKGTGAGYGVGMDLETMLTDAQDNNACVRVEQSPLSSSLLADWLDVSSSLSQADLEALERELQLQSPMNISYSDVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCI4</accession>
    <name>A0ABM0JCI4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101848631</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005090550.1">
        <property type="nucleotide sequence ID" value="XM_005090493.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848631"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16695">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005090550.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="20432" checksum="91D8C0299D9BBAB0" modified="2025-10-08" version="1">MGLKLSTNNQPRMRTYSASTPGSNGGAGTDVVARNGAQSSRARARSLGNFQSSGNSGSLSIPGASGGTHRSSSPDSDSSSPGDDPGLLFGGRPFTHSLPVHLFALQGIKCPVCSKQIASDDIECHLVMCLTKPRISYNEDVLSEDKGECVICFEELIQGDTIARLPCLCIYHKGCIDKWFEVNRSCPEHPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDG7</accession>
    <name>A0ABM0JDG7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101848170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005091177.1">
        <property type="nucleotide sequence ID" value="XM_005091120.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848170"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="72"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005091177.1"/>
        </source>
    </evidence>
    <sequence length="670" mass="76032" checksum="2AB93060B2436223" modified="2025-10-08" version="1">MKMLSSHFWRRVFIHRWQRRLKDFSKISRTLEDKERLLHRSIFSDQKFFSHTSKLWQQHKGLPFDVADFPVERIRNFSIIAHVDHGKSTLADRLLEISGTIPEGNNMQVLDRLQVERERGITVKAQTASLVVNHKGQDFLLNLIDTPGHVDFHYEVSRSLAACHGVILLVDANQGVQAQTVANFYLAFESELAIIPVLNKIDLKNAQPDIVANQIHNLFDIDKDEILKISAKSGLGVADVIEAVIERVPCPQYDRNKPLRAFVFDSWYDKFKGVVAHVAICDGVARKGEKITCASSQKVYEITEIGLMYPTQVPSGALFAGQVGYAMMNMRNTSEAQIGDTFYHENQPVEPMPGFKEATPMVFAGMFPTDQSEFPQMRSAIEKLTLNDRSVQIKVDNSPALGQGYRLGFLGLLHMDVFNQRLEQEFDASVIVTAPNVAYQMTVTGEKNIKYYGSEDITVLNPCLMPEPSNIAEYREPMVKGTIISPDDYINQITGLCLDRRGRITDQSYIDDKRVMFQVNFPLAEILVDFFDELKSISSGYASFDYEDAGYEISDLVKLEFYLNGKDVEELTLICHVSRARDLARQVCLKLKDTIPRQQFAISVQGKVNAKVLAREDIKAYRKDVTAKCYGGDISRKRKLLKQQAEGKKRLRKIGNIDVPKDTFIQILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGF1</accession>
    <name>A0ABM0JGF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101857933</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101857933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093135.1">
        <property type="nucleotide sequence ID" value="XM_005093078.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857933"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005093135.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14328" checksum="39D8CD5B77CAE9EC" modified="2025-10-08" version="1">METTKLTTDEKLQGNQARFRKHRSCVDQIASLCINIEQLLEFEWNSPLVANFIYYEKAFDSVDRETLWKHMRHHGIPDKIVKLVNATYEGTNCQGFHEGQLSEPFQMSCFKTGDAVLDKEDNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGP3</accession>
    <name>A0ABM0JGP3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Splicing factor 3B subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101851713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005093288.1">
        <property type="nucleotide sequence ID" value="XM_005093231.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824342.1">
        <property type="nucleotide sequence ID" value="XM_035968449.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851713"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="14"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="445"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="863"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005093288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035824342.1"/>
        </source>
    </evidence>
    <sequence length="1218" mass="135340" checksum="9F6DA7A17D21943B" modified="2025-10-08" version="1">MYMYNLTLQRSQGIVAAIHGNFSGSKLQEIVVSRGKVIELFRHDPNTGKVFPVLSTEVFGVVRSLMPFRLTGGTKDYVVAGSDSGRIVILEYIPSKNIFERVHQETFGKSGCRRIVPGQYLAVDPKGRAVMIGAVEKQKLVYILNRDAQARLTISSPLEAHKSNTLVYHMVGVDVGFENPTFACLEIDYEEADGDPSGEAALKTQQLLTYYELDLGLNHVVRKHSESLEEHANFLISVPGGHDGPSGVLICSENYITYKNLGDQPDIRCPIPRRRCDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVSASMCVLKSGFLFVAAEFGNHHLYQIAHLGDDDGERMFSSANPLEEGDTFHFSPRELKNLVMVDEMDSLSPIITAQIADLANEDTPQLYTLCGRGPRSTLRVLRHGLEVSEMAVSELPGNPNAVWTVKRHTDDDYDAYIIVSFMSATLVLSIGETVEEVTDSGFLGTTPTISSSQLGDDALVQIYPEGIRHIRSDKRVNEWKTPGKKTIVKCAVNQRQVVIALSDGELVYFEMDPTGQLNEYTERKSMTSAVVCMALGRVPAGELRSRFLAVGLSDNTVRIISLDPNDCLSPLSMQALPAPPESLCIIEMGGTEAKEESGEAGTAGGIYLNIGLQNGVLLRTVLDTVTGDLSDTRTRYLGSRAVKLFRISMQGSEAVLAMSSRTWLSYTYQSRFHLTPLSYETLEYASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAWPLQYTPRKFVIHPESNNLIIIETDHNAYTEETKQLRKQHMAEELIEAADEDERELAAEMAAQFLNEDRPETIFGAPKAGLGMWASAVRVLNPITGENLEKISLDQNEAAHSVALIKFANRPDDTFLIVGIAKDLVLNPRSISGGELLTYQVTEGGNKLELLHKTPVEDIPGAITPFQGRVLIGVGRYLRIYDLGKKKLLRKCENKHIPNFIVSVHCLGQRVVVGDVQESFHFLRYRRPENQLVIFCDDTNPRWVTCSCLLDYNTVAGADKFGNISIIRLPTEVSDDVDEDPTGNKALWDRGLLNGASQKADVVSNFHLGEVVTSLQKATLIPGGSESLVYTTLSGSVGMLVPFTSHEDQDFFQHLEMYMRQEYPSLCGRDHLAFRSYYFPIKNVIDGDLCEMFNSMESSKQKSIAEELEDRSANEVSKKLEDIRTRYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJG5</accession>
    <name>A0ABM0JJG5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="4">EF-Ts</shortName>
            <shortName evidence="4">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095058.1">
        <property type="nucleotide sequence ID" value="XM_005095001.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853540"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14275">
        <property type="entry name" value="UBA_EF-Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25025">
        <property type="entry name" value="EF-Ts_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="7">
        <location>
            <begin position="101"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005095058.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="37703" checksum="6A5C4B787F444DCE" modified="2025-10-08" version="1">MRGLLRPRLWHILQPSLRNFNSTSSCWGVDKSMLSKLRKQTGIPFINCKKALEKFDNDFDEAKKWLLEEAQKAGWARATKLQSRPMSQGLVAVVGDSTQVTMLEVNCETDFVAKNEKFLAMVSKLAQECKSHFEKQSNKTVFVNKEELGQIASSEQGTLADIVALNVGNLGENMALRRGAFLRADKDSVLSFYVHPSAPLKNPKSVLLGKYGAVVEMVQKQSEGKPVMTFSELGSHLCQHIVGMNPKTVGEYSPSTDVEAGRSAKVDGGERDEGAKSIEGENAEDEGSSRPAEEDEEDELLNQEFLLDSSMSVGELVCLNGVDVRGFIRYACGEELEAEKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK04</accession>
    <name>A0ABM0JK04_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 14">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101855716</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Chromosome</location>
            <location evidence="14">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 14"/>
    <dbReference type="RefSeq" id="XP_005095494.3">
        <property type="nucleotide sequence ID" value="XM_005095437.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855716"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14 17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 14" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="237"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005095494.3"/>
        </source>
    </evidence>
    <sequence length="728" mass="84952" checksum="8B2FA0BFB544464E" modified="2025-10-08" version="1">MKCTFDYSTDNSEYTWLNFHTTSFQERLNKNYFIYSGEDSKLPFVTEMVENHRKCPYWTLLKHFCPCALDISLSAKESCCASKNGAKKNMNLSDDFLPVQSIFLFIRCIFLKVVPKSALGNKRNFNTFLKHVQTFLSIQLKGTMSLHYLCANIKVKVIPWIQAEEHRKRRTLLSSAVDFFMMKVIFPLVQSFFYVTESTTHKKRLFFFRKKTWHRLHQQSCAHFIKQCGLKLVPQAWVQEKRQKGLCLGVCTVRFLLKKPSLRPIVNMSQKSHDVSINKHLKALLLALRWLKDQHPVMLGASILSIDDIHCRWKAFTDYVKSKSIKQLYFVKIDIEKCFDTINPCLLYSVVQNQLLSQEKYHIYHYKRNIQSDGQSKVVYYQSSDKPEIECRTRQGAQFVHSFSVSSEVLLKKLQALLFANVIRLGRQHYVQSMGIPQGSSISSILCSFYYGYMDQVKLYEFQRKPNFLVRMIDDMLFVSPSRKRAEAFFTMMIEGVPEFNCKSSLRKCCATFDYSHPEFGRAHTLKPSEPLTFCGLAIDCRSLNILVDFSNNKNITVRDTVSLCLANHPGLQLKKLLSWYLRPKSYAVLFDKDINTETSIITNVLHIFMLVAVKFHSHIKQLPPKQRIESNPNFFLKLIQEMPHMFMKIVVQKLQKSQSSDQGMVSFPLSTLIVKRLCTRAFLYKLRMHDSMYKLLIKQLQVQERQRHKGQDLTIVDLSEVYRAVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK23</accession>
    <name>A0ABM0JK23_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Craniofacial development protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095538.1">
        <property type="nucleotide sequence ID" value="XM_005095481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845458"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF67">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005095538.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28004" checksum="C416AA179D716CBB" modified="2025-10-08" version="1">MTTGLDTTNLEKTENIRKTAIIDRELTRLNVDITALQETRLANSGTNRERNYTFFWKGLGEDERRIHGVGFAVHNRLLNRISTPQGISERITVMEMENKTGKAHFISAYAPTRTTENEKKDQFFEEHQDAINNVPKADQLFLTGDFNARVGTENKVLPTSLGPFGLGKINENGQRLLEFCTNNNLCISNTFYSGNDRHKVSWCRPRLGHWQQIDFIIVRKKDANMVKQTRSFYSADCNTHHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK74</accession>
    <name>A0ABM0JK74_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101851183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095648.2">
        <property type="nucleotide sequence ID" value="XM_005095591.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851183"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045590732" evidence="3">
        <location>
            <begin position="31"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005095648.2"/>
        </source>
    </evidence>
    <sequence length="329" mass="35530" checksum="199FAB2B513C08A4" modified="2025-10-08" version="1">MLYSNVLRIMEKQIILFFCLLALAVTTVSGQSTVPPGTTDSGITSSGNNTSNATAAAPTNASVTASANETTVTMTTTLPPTTTTTPAAADLPHLDTATFTWSLTLGTDNTSDLVIVDANASVADLSSTLWTAFSEFSSGYELLQSNTDDKNFTFRLYFLSSKLTNSTTDQLNNTLTQLSTDVTVNHQAFTSLEQFSSQTADICTAEHACSEGFFCVPSGCRHLCHTADQYCGQHGQCHAQVTQEGKAALFCTCESSYSTEYFGDRCQDSHMGKDKVIAIVAALLGVIVFLLLVALLITCIKRRVYKTPQEYVFSREAYVNSTYENTPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK90</accession>
    <name>A0ABM0JK90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101856414</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WSCD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095669.2">
        <property type="nucleotide sequence ID" value="XM_005095612.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856414"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005095669.2"/>
        </source>
    </evidence>
    <sequence length="426" mass="48929" checksum="92AF068C0BA4880F" modified="2025-10-08" version="1">MFHYKTVVVHHCGRFQWGYIIYFVFLLTFLLQMAFTFTSRYSVLKFQKSRTFEQKMLALKTENTDSSKSEKAIVFDNENRRSSTPLIKTKVARKDDTWNAPESLTFSGTTPKSWMLSKIPPDNCSQLFSDEAATRKWAVSSFRRFCSLDSVYPIPQSISKQKNRVMFQICKGLLRPVRRVSKACPRDPAIAPYTLPRTGLISFPGSGNTWTRHLIQQLTGLQTGSIYNDKQLLNEGFPGEGQEDGVVVVKSHLDDPTARGFKNFEKILLIVRNPYDALVSEYKRGRLGMSHTGDAFIKQTSLDWQTYVEHKGRSWGRMIFRVLQHPVPVLVVYYEDMKNNLLPELIKIADFLKTSQLSQFSLCCAMRNQEGRHHRNASLQHSLYDNKRRGTVNSVIKDIVDKLRITHQAVADRIKMYTLVDPGKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKI2</accession>
    <name>A0ABM0JKI2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Essential for reactive oxygen species protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC101857869</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYBC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095849.1">
        <property type="nucleotide sequence ID" value="XM_005095792.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095850.1">
        <property type="nucleotide sequence ID" value="XM_005095793.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857869"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027846">
        <property type="entry name" value="Cybc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31837">
        <property type="entry name" value="CYTOCHROME B-245 CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31837:SF3">
        <property type="entry name" value="CYTOCHROME B-245 CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15169">
        <property type="entry name" value="Cybc1_Eros"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005095849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005095850.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24193" checksum="8B0FC20E6891D05A" modified="2025-10-08" version="1">MVYMSVLHDSDTRLKLLREPSLLSKAVFIGFLIGVIGVFLFGSESCFFKVLIGLVTVGLSFFMVDNYEICEFDKEQGEVRLSRLHWFQYLLDVGMQPYIVVKLEDIKDVKIEEQGGDAGKRSFQVALSLYSGVQLGITEIFTTDPIEQHKALSKKIMSFVSSTAPTYGVDDVDKESRDEDKSSEDDDEDDFEQISKADLEDMEEGPASKETEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLT1</accession>
    <name>A0ABM0JLT1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101853782</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005096682.1">
        <property type="nucleotide sequence ID" value="XM_005096625.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853782"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005096682.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40569" checksum="A9007CBA6C3CEE30" modified="2025-10-08" version="1">MTMSTTTASFPQLTSMTSSPDREMSGMVSQDVSDWIRTVVGVWLCSLLSALGITTNALVIAVFAKQGFKDSMAISMTAIAVWDFLKCVCCLIGRLYWVMGLTDPPLGQMWADVTAILLTYLHSFMGFVSCALAAYVSTERCLCVSMPFKVKDIFTRKLTIIMMVVISTIVLGSFMVVFALWEVRVNFDPVRNTSTTTLVFSDFRRQHGVSVLLYYNIVSIFWPLLSFVVIVVSAVIITHHLQKSSEFRGKNVNSQESQMSARDLQVIKMLIVIIVVYIVNLFPRIVQYFARFVEPEFYLGMRYHNLFIVVINVVFIFDFVNASTNLFIFVTMSSNFRSTFVDMFGDWWVIQNKKDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM06</accession>
    <name>A0ABM0JM06_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Ankyrin repeat and SOCS box protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC101847334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096823.1">
        <property type="nucleotide sequence ID" value="XM_005096766.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937044.1">
        <property type="nucleotide sequence ID" value="XM_013081590.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937045.1">
        <property type="nucleotide sequence ID" value="XM_013081591.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847334"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SOCS box" evidence="3">
        <location>
            <begin position="296"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005096823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012937044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012937045.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40295" checksum="CA29606E6B50A90D" modified="2025-10-08" version="1">MQEAIYFYDSAQAQRYYYNQATLQHTFYQEFSECFVQQAFEICPGHEQDFADTVRKIDAARPGFVQSWHVGFALMRAIAYGRPDVIISLLYGGVDVNQTFRGRSMVHEAVKQGNSDMLEFVLSLPGIEKDAYDVTGKTALMHATGSTPECLKVLLDAGCNMFLKDGEGNSAIHQPFKTLDSSCGNVVECLDMLLRYGAHLGARGAQGKTCLQRAVEMGNHLLVHWLIMRNVDLQQHVTNVHIILDTQLYRSRDLYDNVLLLAVHQADRKLMEVLIACGCSFRHYSWLLPYCKSFRMLHASLQGALSQVGSLQSLCRAVIRPCLSNDIERDVACLGIPRPLQSFLLCRGETQVLVQDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM24</accession>
    <name>A0ABM0JM24_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101858178 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096865.1">
        <property type="nucleotide sequence ID" value="XM_005096808.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858178"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046489495" evidence="2">
        <location>
            <begin position="25"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096865.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="67342" checksum="1B74AFD933A58D87" modified="2025-10-08" version="1">MADFVENVLLYVALTFLCVININGDQCGCSIEERVTRLENEFSNLRNEHRQLQTVVEENIGRRNQSSANITESTQTGYYGVDNDHRNQSSPNITESTQTGYYGVDNDHRNQSSPNITESTQTGYYGVDMGRHNRSGSNYAESAPTETVTGDDGDVVVQEVRRTRVPEGVKFTVRYYASPYTDLRVRWTDDSGANIELEPTLVLTTERGVFESEVVTAPQSNSSVTVRLRTPKQRLSLQLRNVEEDDVLQRDISFPVLRTIPQGDIVYEQGQNVDFQIVRSRGNGSSPVTSSKRYIILNPIDHTKAIIVVSYSDFEFSSVEAETTSQGLEYLTRRLRMTSRPTSGVVLYTLNMPKSDVLIERAQIRRTVVIRPSTQSEAFPRGFLDIPNSRYNEILGNRSEVATCSNMITPGCFIACYGAGEDIVRMTLWKVRANGYKERVEEQQVGEDDHYGYVVKKVQPDSGPVSQSHYQCEAVNTEGEIVTRDYFVNFIIGAEIIQEESRVTRINETLVEVQCVAAGNPPPEVLFFLTYGEFKQRDIEPSSVSTNAQNHVVATLYAPTSTTGDYYRPGGPLNKAACNARGPIGGEYSFDYYEWPVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM80</accession>
    <name>A0ABM0JM80_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005096978.2">
        <property type="nucleotide sequence ID" value="XM_005096921.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845845"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045632323" description="acid phosphatase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005096978.2"/>
        </source>
    </evidence>
    <sequence length="422" mass="47993" checksum="9088DD8CA9F3F741" modified="2025-10-08" version="1">MDVKEFGSLSMKRLIQLCLCVCCGLQVFGAPPPTLKLVSVLYRHGDRSPAYIYPKDIHQVPGSWPDGLGWLSNIGKQQQYELGQFIAERYSGFLNTSYYHRDQILIQSSGVERCLMSAQSNLAGLFPPQGPQVWNSNFTWQPIPVQSTPTQNDNKLAIQAPCPRYDQLMAEVLHSPAIQKEEKENKAFYDMVINATGVKKESIRDIWMIADPLICERAHNYSWNEWAYQEGVWEKMDSLRTLSFDLLYRRTEMAKLKGGPLLKEIIYNMKNASGESSPSPRFYMYSAHDTTVAAFLSAMQVFDLHQPMYRALVMVELHHINDQHVVKIFYRNETTADPYELSPPGCKNPCTLDSFIEATKATVPEDWEKECQALNSSASHKLSPASWIALVIGICFCSILCVVLVVMVLRLRTKRNATYSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMC5</accession>
    <name>A0ABM0JMC5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RING finger protein 141</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101845917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097059.1">
        <property type="nucleotide sequence ID" value="XM_005097002.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845917"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16545">
        <property type="entry name" value="RING-HC_RNF141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043400">
        <property type="entry name" value="RING-HC_RNF141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047126">
        <property type="entry name" value="RNF141-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109:SF3">
        <property type="entry name" value="RING FINGER PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109">
        <property type="entry name" value="RING FINGER PROTEIN 141-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005097059.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27585" checksum="F52B5AE36FDF8E77" modified="2025-10-08" version="1">MGQATSSVSTADGDLRQLQGQFAANFNIVKSLATVSHAEVVDCIEELNTVTRSFTDRAGKQLRFLIKRGTDTTFLWKGTIRIRCLKINTSTSVIESSRLLTLRQFVVTYKEIIEQVAMLSRAPADPSAQEDSAPGTSAREELTASAFFPESKKQAHTEVEEDPVNECCVCMDRKACVMLSCCHEFCEICIDNWTRDERHSNCPLCRTKVAGHDDTWILTDKTDTSDYEGELKGYLVGLADRSRGSTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNF4</accession>
    <name>A0ABM0JNF4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101854408</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097793.1">
        <property type="nucleotide sequence ID" value="XM_005097736.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854408"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047278421" evidence="1">
        <location>
            <begin position="20"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="192"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097793.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35281" checksum="75CD114452E8917E" modified="2025-10-08" version="1">MMRCYFPVLLVCGWQLAAAVLDLHTSPNEIQPCTDLQVTIACSFFDHNSTEYSRLVSMTISQLGQTSSAVDLASVDSFSGSQVHTRDVPGVSVTGNITSTATEGHLVLNYPVLHLGEGGHFVCESTSIDYFGHAHQETATATVEQITPDENPGNTISTIILSEFKRLLEKRDYLTPGYYSYDENEVAASGTHEGHTYLASKEALSYEIAWLKCAQKGGYLAEINTQEEYNFVTGFLKNATQDHLPHGLRYFITGGIVNGTTFHFRRHPEDPMYIVWAYYEPGYNDTPCLSLDKENFKFADTVCANTDVSSLCELPYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP40</accession>
    <name>A0ABM0JP40_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855188</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098224.1">
        <property type="nucleotide sequence ID" value="XM_005098167.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855188"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098224.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39966" checksum="F66919BBD03BC25A" modified="2025-10-08" version="1">MPSQEAPSYSSARVQRATRINNIEAARLQQRLQYIEKAKLHQCRLANQDMRLISLSIDYIQASSGHSPEAWRPETQKGSEEIVDEADQGPLFMYGERIVSRKKRRMPRPMSAVERSSSMFMDHSSIADESVTSDRPKSSPGKPRPTTSMGFLRVNASFDSDTEAGSSEHDGPTSSRPSTSASRVTPRQDWGEDTSEMTKKILRAQERSQSGKRSVYQSAEEVMSAQASRHLRGLARKTRISSAVSTSSRPTSSISRHSVENQDFAPKRPPDMVEGLGRRATFGEILNQRRPTMNAGAWRSHLSQTSATPMSTQAHSQMLMSAKKMINDSRLERVNERVQSFISGDRNPPRRAQSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR34</accession>
    <name>A0ABM0JR34_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101863439</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM242 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099543.1">
        <property type="nucleotide sequence ID" value="XM_005099486.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863439"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009792">
        <property type="entry name" value="TMEM242"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07096">
        <property type="entry name" value="DUF1358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005099543.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18097" checksum="4F1835290CA01AD1" modified="2025-10-08" version="1">MSSVSHENQVQDGDDRNTTTNAGFDKYYRLKAGVFLASVTGMSILGGFGMTLAMAKKQDPQMFTKGFAGSREIPESGVSLATRALARGSLYSVAGVGIFCYAVWKLLGVHSMVEFRQKVGTILPTIPKKDNPGRGDFMTIRDLFNYIIEEDEKEKREKKAKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSJ4</accession>
    <name>A0ABM0JSJ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101852099</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100511.2">
        <property type="nucleotide sequence ID" value="XM_005100454.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852099"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045710212" evidence="2">
        <location>
            <begin position="37"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100511.2"/>
        </source>
    </evidence>
    <sequence length="660" mass="73171" checksum="C84D7D83F2BFFBE1" modified="2025-10-08" version="1">MAGIRRFLCPGRDSYPKIIFTSTLFILLVFCGGTTAAPTVSKQSDVVALTRYNTRNDMNTGQTGHKVSSGTTPIPSRAESSDNIAIITERAHSNGDPVSADGKGEGRGFPDINGEQGVHTSTNKSNRLEESDSVSEANDAENIPNISKNMLALDSTPSPHARGGGDVRSTLSRHDNSVVSGSKRKINGSRIQRRRRRKADKSRRWSVDAGQKLLDNFPLGNYQYFQSCPNDTLYRNEERINDLRAIFTMCQKLQDVLLIREIVNSHQDLEPFWAVTSHLMSMLSVANQFGISHYECQLVPAQLFLEYAEEVFEGNKFHRSVMESLQTLHDMIIGRSTHLGRSPVLKIYEKRLPASLKQSKQWYVGGLLEYLTLLQAGGYAVYQASVNVLEEQVSNNATMSTFTKLAMAQEISLKKWMIRVKDFYVNPGVEPFFSFTALKETDTAVSVDTGVLGFTPKEASISSTNDGSVHQALQFVQVKGCQLSDQRDSLSLRCSVRKHPKCGTLSEAKSKGVASASNNWVEREVATQDILTPNHTRQSYESLSCVMTSWVRASKPGQTVCAVKLNVNAQTNCLGLGVYFCSMDSCDVRANQGWAFSKSSSGSALKKRKKRKASSTWDWARSNYIVDSHMTLPEFDGRVTGIRLYNKNGQLAIGLRTAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSL6</accession>
    <name>A0ABM0JSL6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101860661</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101860661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100549.1">
        <property type="nucleotide sequence ID" value="XM_005100492.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860661"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009511">
        <property type="entry name" value="MAD1/Cdc20-bound-Mad2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681:SF1">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06581">
        <property type="entry name" value="p31comet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005100549.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="46052" checksum="EFC0CDB02E7209FC" modified="2025-10-08" version="1">MAGVSISNERRHTPLPCSYDIVFDGAILSRNRGSLVVELIKYLLYERQQIPVPFDDLDKFLRSTRTNSQSHSRFHHQNGQFGQSESLARTFLSKFSSSKNHQQQKTEGVITNLSNIFDQLRKAFESCPEIEQVAVVFGATVVSPKESYVINFPPPCADADCLPFLSCKRTLFKQIIDKDILGVMRHDLSPTNMMLLLSAPRTCPVQWFLPKISLGAPQRGNVISFNFYCSYVVPFCHDLTFNGDVSVLSGIELLDCSQCQQEDLQTPAGTEGDGHCAANGVLPVKCKRTLIPEIGVNGVRVGAAAEHESSNGNASSEEYCLTSQCTHVEQSVNGVASRTSCHSCSGRDAASEASVSTRKCQRRSFSGLKDETGGGVKALEHVHFASPRVALVGRQSDSQTSSVDCIWYQSPLTVKGFKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUV6</accession>
    <name>A0ABM0JUV6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0561 protein C2orf68 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0561 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102058.1">
        <property type="nucleotide sequence ID" value="XM_005102001.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857807"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018888">
        <property type="entry name" value="UPF0561"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34256">
        <property type="entry name" value="UPF0561 PROTEIN C2ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34256:SF1">
        <property type="entry name" value="UPF0561 PROTEIN C2ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10573">
        <property type="entry name" value="UPF0561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005102058.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15499" checksum="FB9F8B77F5E23457" modified="2025-10-08" version="1">MTSHQPKQRINMSHGFMKSVIRNQIDRDNYDKEVKAKQEQVQGKPRGRGSGNRSKKPEIQTYVPPQRSKKDPQENLFTVEYEHKTGEIHKVSMSKVDIPEEVAKKIGAKFELPSVFVDALAQRLHEEMEQRADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVP0</accession>
    <name>A0ABM0JVP0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864404 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102619.1">
        <property type="nucleotide sequence ID" value="XM_005102562.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864404"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055121">
        <property type="entry name" value="HTH_69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705">
        <property type="entry name" value="AGAP000321-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705:SF1">
        <property type="entry name" value="PNP_UDP_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22979">
        <property type="entry name" value="HTH_69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Winged helix-turn-helix" evidence="1">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102619.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="66591" checksum="CCE5D4D1CC0953AB" modified="2025-10-08" version="1">MADEEVVMTPSKRGKVTHIKIERKKKQQVNPEDVVHVAGGQHQGLVVNRPDAADEDLGKPQLQLGFMCFLVDQKTDEQYVESRKLKFWYVTGCDYYNQVTTAYEFFKELVRPENFPRDYVGFIKKCMKQMQSDRYKLARKIDLEVEHVDAEDAPMSPGHFLPLEQFGLENINGVGFNKVDTRPIEEIVREKLLTVLESAYPNVLSVEDLVRITAADAAVVNMQLQELQARELIQPMENGGFVRRVLDEKTEVQMVKSMPMIATNLQPTIAIITAQYCEKMAVDAMMESKTTYVRYKTEGESNVYTTGLIGEHKVVTTKLPAIGHYRAAQISSGNTTTRLLGTFQNIEHVFLVGCSGSVPHFTDYYKHGRLGDVVISTCDDRGYIYYYCDKIMQDKEGQIQYQLKTFSPRDLELQRLAEKLRDTLHHEPNYAPWEQYIEEGQELLQSQEQDYTRPVRAKDRLYMGIGEGQVIEVQHPEAPDGEAIRESPTMRFGVFGAGRPVKSEMSRHDFASRYGITSFDTEFDQVLESIVGNRKDSFMFVRGLADYVDGSKNKEWQPYAALSAAAVVKFIIMSLRNHQLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVW4</accession>
    <name>A0ABM0JVW4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S31, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101850098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102736.2">
        <property type="nucleotide sequence ID" value="XM_005102679.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850098"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026299">
        <property type="entry name" value="MRP-S31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15433">
        <property type="entry name" value="MRP-S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005102736.2"/>
        </source>
    </evidence>
    <sequence length="365" mass="41067" checksum="809D2D5CE037D6D4" modified="2025-10-08" version="1">MIRSQLVRLVRTVHSKGNFTADLGSIGRPCGKLASCPVQVTCQRNFRATAVRGDESQDSNDAPGRPLARPRIKNKKRAGVKVSQELEQAAVKAAKSLPGDWTKTADELLARLSSHQEPKVMSQEEQAGEVPPARDVSEPSLLETMQVGRGFKPQRGRGDGGDQRSGGLGLQDDDMYNRSATQFSGSRTQMGGRRVARRTEVFKDIFSVPRIEIFDAEKVKSKEGDSATVLGQGLSERVEQEKLHHMQGGLPRNAFEEMIEWTREGKMWTFPVDNEADMWEERQYKFHQHVFLDGDLEQFPARGPVRKFMELVVLGLSQNPWMSVPEKRGHIAWFAEYFREKQDLLESSLGLEGRMKEKEGVKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWL2</accession>
    <name>A0ABM0JWL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tubulin epsilon chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103226.1">
        <property type="nucleotide sequence ID" value="XM_005103169.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846437"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02190">
        <property type="entry name" value="epsilon_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004057">
        <property type="entry name" value="Epsilon_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01519">
        <property type="entry name" value="EPSLNTUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="56"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="7">
        <location>
            <begin position="287"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005103226.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="53653" checksum="032AC66EE80C247D" modified="2025-10-08" version="1">MTQSVIVQVGQCGNQIGCRFWDLALREHASVNKNGIYDESIGSFFRNVDGRHDDPADIPVGTGTGKIKSLKARAVLVDMEEGVVSEMMKGPLGEVFDCRQLLTDVSGSGNNWATGHHLYGTQYKEQISEVVRRAAEFCDCLQCFFVLHSMGGGTGSGVGTSILGLLEDEYPDVYRFVTAVYPSSEDDVITSPYNAVLAMRELTEHADCVLPIENQALVDIVNKISQAAPPTRPGKRVFSEHAVKPDSALSTGAGGVVKDEKPFDQMNNLVANLLLNLTSSARFEGSLNVDLNEITMNLVPFPRMHYLIASQTPLFCSADVKMPPRRLDQMFTDAFARDHQMVRADPRHSVYQACALMVRGDVQLSDIRRNIDRLKPNLHFVPWNQEGWKTGLCSVPPVGQPRCLLSLANNSCIHQTFSEIRDRFSKLYKRKAHLHHYNQVEGMDSGQFADSLESLTSVIEQYRDLETAMNQPVVAEPRLKVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JX14</accession>
    <name>A0ABM0JX14_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable RNA-binding protein 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">RNA-binding motif protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101845411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103562.1">
        <property type="nucleotide sequence ID" value="XM_005103505.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845411"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12355">
        <property type="entry name" value="RRM_RBM18"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039157">
        <property type="entry name" value="RBM18_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="94"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005103562.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="30947" checksum="510B4A3A5255689D" modified="2025-10-08" version="1">MSSQDKTLTKNADTRGKSSDNSRRIELKLTTGTSGGSSSDVEVKPSEKVAGLTEDSASGDEDAAAVSESTSGLPPVVDNLDIPDDPFGDEYTDRRLWIGNLDSRMTEFSILKLTQKFGSIRKMDFVYHKSGPEKGKSKGYCFVSFHTWEAADNARRALDGKFAMSRPMYVKWAQGARELIEPAPQIPTISSLPTSTVQSATSSSLKASLAAASETVSTDAKIRAIEAKLQMMDATKKDFSLGETIRPPPGWTPLTTVHQKDDRSRSGPYRKSQHLSGVRHKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXG8</accession>
    <name>A0ABM0JXG8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101853334</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005103845.1">
        <property type="nucleotide sequence ID" value="XM_005103788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853334"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005103845.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38674" checksum="E29AF41A11ECFA94" modified="2025-10-08" version="1">MGAETRMFEDSEPNELVSREFRDVCQQSLQIVILFINVFGVFTNGINIRVFIRQGIASDTTTIGLSALALSDLLGCFFMIPASLCYVIKFLDYIDYRNCVALTTVPCHYPHVMFSRITCWLTVYISVERTLCVMMPLKVKFLLRPKVARNAVSFVFFFFVVFHIPFAANTRIVWEFDPAFNQSMAVNRETKSGQLLFYINSLLGTTILSTVAMVIVAVTTSVMLYKLKTTQKWRKSVSLVSTKSASSASKEHEVFQTVTMVTAIYLVCQVGGHTPGFATLFFPGVSVSGLNKNLSLVMYTFKFFFDAVNSSVNFIFYIRISSRFKAAFSSIYNHNLRDMGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXH5</accession>
    <name>A0ABM0JXH5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101856279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005103857.3">
        <property type="nucleotide sequence ID" value="XM_005103800.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856279"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF2">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="103"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005103857.3"/>
        </source>
    </evidence>
    <sequence length="531" mass="58525" checksum="C808DF5AABED6D60" modified="2025-10-08" version="1">MLISRLTTMAALMRKVVMPPCVLPKHIVRCLMTTKIEHMNICKSLFAIQDNCKSSSTYLTCAMISQCLTFSRMLSYSHPCQNKKGRSTESKSQIDKAGVVPRKPHCNVGTIGHVDHGKTTLTAAITKVLSETYSEENKFVSYDSIDRAPEERKRGITINSAHIEYVTPNRHYAHTDCPGHIDYVKNMITGASQMDGAVLVVAATDGTMPQTREHLLLAKQIGVKYIVVFINKADAVDNEMVELVEMEVREVMTEYGFDGENCPVVYGSALQALNGENSSLGKDKILELMKAVDNYFPTPERKLDEPFVLPIEKVVSVPGRGTVAVGTLKNGILRKGDAAEVVGFGNSVKTVVSDIQVFGKSLKECVAGENIGALLRGVKNDVIQRGMILGPPSSLTQCDAFKAQFYLLTQQEGGRARPITNNYIQMMYCNTWNISACVRLPEGTNMLMPGEATHGEVLLRLPMVISPGHRFTVRQNNITTLTGLVTEVLPPTELRIRGFNEEKQVTHVIQGNAQVTRSARMKRKKSNTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZT5</accession>
    <name>A0ABM0JZT5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 13 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105402.1">
        <property type="nucleotide sequence ID" value="XM_005105345.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853721"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046685621" evidence="7">
        <location>
            <begin position="30"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005105402.1"/>
        </source>
    </evidence>
    <sequence length="611" mass="66919" checksum="D0DC950B75F918D8" modified="2025-10-08" version="1">MSILKDLLLIRKVLIVILVPLVCLPLALSESKEMTCSYGVIIMAVFWITEALPIPVTAFCSVIVFPITGIITSKDIARVFFQQNTTFIMVTLCFALAVEKCGLHTRVALFTLKQVGTSPRRLLLGFMLPTWFLSMWISNTSTTAMMMPIVLSVIEEMKYFRIDVSEQGGDQFSKKKNSSFDIADASQSGDAVGENERPLLKYDDIEETSTIKISRRVDSDKVNKRQEKKAFESMCTAFVLSICYSSSVGGGASLTGTLPNIIMASQADEIFASYGLESNVNFLTWFVVGLPISVVNLIVTWSWLSLRFFGVRSLFHNQTPTEKENRKAIADRITEKFDSLGPMTFAEIAVCAFFLTLVSLWLSIKTPNGGGWGALFTPGYVTTATVGVIIIAIMFLFPSECPTFLRNNKNDKDKLLQTSRRIFRGGALLDWKMVQERLPWGVLMLMGGGLVIAKSAQVSGLSKWIGVRLEVFSSLPPWLCAAIMSLVISFMTEISNGSTVASIICPILGRLAQTLGVHPLLFLFPGTMACSYAFMLPVACAPNNIAYSTGLVPSRVMMTTGFVLDILCVLVLNTGINTYTTSYLDLTSSPFNATLATALTSVEGNSSALTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZW0</accession>
    <name>A0ABM0JZW0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apolipoprotein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105449.2">
        <property type="nucleotide sequence ID" value="XM_005105392.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864645"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105449.2"/>
        </source>
    </evidence>
    <sequence length="103" mass="11361" checksum="B6BA6347CBFB30B7" modified="2025-10-08" version="1">MIEGQAEAVYPAEPARLRVSFFGDDEDGDANYLVVDTDYDTYSVVFSCQQIGPFNLQTAWILSRNETAPANIDDLKNTLTSFGIDVSEFQETPQGNCPSMAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K141</accession>
    <name>A0ABM0K141_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-related transmembrane protein 2-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106287.1">
        <property type="nucleotide sequence ID" value="XM_005106230.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860355"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="132"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106287.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30820" checksum="460714E2BBB91B68" modified="2025-10-08" version="1">MTFFQELRPLLKPHYISNLLIAVLYFILKSTPGVCETLFRSCQLELREYEWLTFLACVVVLKNRKQGNIEEYVSTACLFTKALSTICFFNYSISYGLLYILLCLAHVMFLPKPVYMGPESIVYFRGPNLCEEIERDRKVTWLITFFVAWSPKCVTFAPVFSELSHGYSLDNLKFGKIDVSRYPEIAEKYNINIGALSRQLPTVILFQEGKESERRPVPTKHMTLKFDFTKENVLREFQLNDVYHECKKALSARKKDKAQDKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1I6</accession>
    <name>A0ABM0K1I6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101847836</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101847836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106577.1">
        <property type="nucleotide sequence ID" value="XM_005106520.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847836"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005106577.1"/>
        </source>
    </evidence>
    <sequence length="800" mass="86971" checksum="CAD3CC44DB0815D3" modified="2025-10-08" version="1">MTDARSRRSSAKSLSFTVDLPTAALHQLQFLELCDSELSLRKENVLKQALYRYQFFWLPLAAKHPQKHLEAPLDVAWVWHCHMLCPVTYCDDCVRLVGVVVDHSLDRSMKLRNKHLNESAQLWQAEYPNEPFEVDLSPGAPLNQDFVNTATDFSYDIIAAADRQKEFFYQVRLPHYKDKKYLENSFQRYKKFLYLKQQRPGMFLVPCYDIDLMWHSHQLYPLKYKEDMKRILGKLFNHDDSVNDRSEGSKLYNADLATRVAWKEVFGEGFALYGAMYRGENPQGKLSAITEEELISLTTRSAHLNFEKISIKASPAIKGKPSLKVFTAVNSKKIAPIGTLKGVEQGWQDKSLMQCGFETRSVNCVKFRLRECTGWACLGSKTTVAETSFDMLQVIETIPVGQSQQLELSTPTSANSQFQVDFQVQVGPVKKGPILLFLRPGQYESCIMPEHLESLWGPVPLMRLPPAVDNKCEVASHRLLNHRGGVVFTCRVIHSIPLLQSAIHVFYKDRMVAVAHLISTDTLPLPPQLVNRSNSPSLNPKALERAILIKNHKGDWAVVTGRWTGYKKGVAGIPGTSSSRGTRGVKGNPGTLSFKIWNMGSSNNVTQLTLPYDSQRYSLQLPGVVVDLKAGAVMLNETTKEVAENLALAFSVSLLHVLCQPRPAGWKPGQSLKLPSSRGSQAVQTIPSEDMSFVMAAGFIMATPSNHHMRENYGLYACAGCGGAGDFGGEGFVSDFGDVDCGSVGGGDVGDAGGDAGGDGGAGCGGCGGCGGCGGCGGGGGCGGGGCGGGCGGGCGGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1Q8</accession>
    <name>A0ABM0K1Q8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101853812</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106692.2">
        <property type="nucleotide sequence ID" value="XM_005106635.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853812"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029201">
        <property type="entry name" value="Jiraiya"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39947">
        <property type="entry name" value="IP19862P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39947:SF1">
        <property type="entry name" value="IP19862P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15038">
        <property type="entry name" value="Jiraiya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106692.2"/>
        </source>
    </evidence>
    <sequence length="230" mass="24872" checksum="41B1DB1B3F1C784B" modified="2025-10-08" version="1">MMLDLGRSTDSCRTDSRDLLEVVLEKKEDEPARAVEVTGPRLTSLLARNNLDLSRSVKVPPPSAPSFCRRSPNLSRLSLASDPPDSDLLKAPSLDTFTHSLTLISLSSLLLAGLAFYVMNTFINMQEPPPSTESVGCRRSSSDFGSKEASTKVSEAATTSNSSSEVVGNDSLLKAGFALSSMVLSSCLCCLMVCTMQCYFTAKILKTSEGEERAHKYLRECSSSRILALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1V0</accession>
    <name>A0ABM0K1V0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Protein LZIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101847897</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTNNBIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106751.1">
        <property type="nucleotide sequence ID" value="XM_005106694.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005106752.1">
        <property type="nucleotide sequence ID" value="XM_005106695.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847897"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.490">
        <property type="entry name" value="Beta-catenin-interacting ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009428">
        <property type="entry name" value="ICAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036911">
        <property type="entry name" value="ICAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040065">
        <property type="entry name" value="LZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505:SF8">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06384">
        <property type="entry name" value="ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81730">
        <property type="entry name" value="beta-catenin-interacting protein ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-catenin-interacting ICAT" evidence="3">
        <location>
            <begin position="113"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005106751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005106752.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21237" checksum="136855E47013B21E" modified="2025-10-08" version="1">MASRGKQETGKLRQNLEEQLDRLVQQLSDLEECKADLEPEEYEETKSETVEQLKEFQENLNRMLEGNLSLVDELNAMQLAIQAAISDAFKTPEVIRLFAKKQPGQLRTRLADISRDEKIGKLPKELAIQQSVEILTALKKLGEQLTAPETAYLEQHSSGSLRQFEKVSADLGSGEKVLAVAGSQVEQANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2Z7</accession>
    <name>A0ABM0K2Z7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107563.1">
        <property type="nucleotide sequence ID" value="XM_005107506.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858667"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005107563.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18459" checksum="9353FD32ED87AD7B" modified="2025-10-08" version="1">MSKRKHPSGAASLSQYRDQHFRGNRHEQEQKLLASSTLYIGNLSFYTSEGQIHELFGRAGDVKRIVMGLDKVKKTPCGFCFVEYYTRSDAEVAIRYINGTRLDDRIIRTDWDTGFKEGRQYGRGKTGGQVRDEYRTDYDEARGGYGKMLANKIRRTSDVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4B2</accession>
    <name>A0ABM0K4B2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ficolin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108417.1">
        <property type="nucleotide sequence ID" value="XM_005108360.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859270"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005108417.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20647" checksum="DD22C43CACD6F0EE" modified="2025-10-08" version="1">MMTGLTNWRNVLLCLQRRASGDVDFYRGWTEYKNGFGNLNGNFWFGLEKIHQLTNQGRYQLRIDLKYKGKYYYASYKNFSLSGESENYKIHVSGFSGNVKDSMAAHNGQQFSTKDRDNDQATFSCATKYHGAWWYKYCHQVHLNGVWGSTVLAKGLNWASLTGWTNSVSFSEMKIRPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4R3</accession>
    <name>A0ABM0K4R3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Toll-like receptor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC101848691</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108716.1">
        <property type="nucleotide sequence ID" value="XM_005108659.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108717.1">
        <property type="nucleotide sequence ID" value="XM_005108660.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108718.1">
        <property type="nucleotide sequence ID" value="XM_005108661.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848691"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021129" evidence="12">
        <location>
            <begin position="28"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="877"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005108716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005108717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005108718.1"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117998" checksum="E2909555EE2F8EEA" modified="2025-10-08" version="1">MMTPQLGSAGPVLLTIVLAALGNCCLGETAVNESNVTRAAMVRRDLHLVPSCGSQSLSPGRDIRCDVNLLDSDVVSTSPQPSQLLVETPAELLKYGTPVNRFRCGACVCVNASRKATLADCNFRHTRWSLHRVPNWLPPTSQSIDFSNNRIKQLMSQNLTLYPNLLALNMSNNLLSSIDSASMEMPNFWSPVKILDISFNEVENITDYAFENLSNLTHLFAARIQVSRITNFTFAGLHSLEVLDLSYGIIGHIETGAFRSLERLSILLLTHNIRLSSYKMTSDLFRPLRQLFKLDIAGSSGGQNVPSQSLSVLHNLSELYVDGNKILHFGPEVRNLSKLYTVYVGKNGFCNLVAITPDMFENLIYLKKFAVIDCKLSSIDTMALRSLKHLEEFVLSKPSDITIRQALNLIPYLNNSTLKSLFFDNFHELGGYRMPAIGYNESRLFQGLTKLEVLRMETLHLFFIEPRFVENLPQSLRYLSFKGNRLHSVNILRSLLDSGKLRGLVEFDISDQNYFVSSDPRLREIHKQNTTQTLSPYDPILNPLKIWHLAQRPSHMSSHPESRLMHMGLPLRPRATTNKSPRSLPIYRANNAFKFGDPILRLKSLHVEQVYFSNGYLNSWGTLQLPSTSVVADLSDNKCDEISMRFLPAQNQMEVLSAQRNYLGNALARDYVGNTFVRAYRVTYLDLSHNSIYRLPYKVFQNMSKIRVIVLTDNHLQALDIKLSHMASLSFLDLRRNSVSWISKRSRDDLDTLAMSHTVTLALENNPLPCTCNGLEVLSWIAFTRVRILDQDFLQCRDKDQRIFPMGDIKTRFRVLRRSCVSYAYIVSVSASSVGVALVIITSALLVRNRWRLCYWKNIILARYYGMRQPGENNVNYKFDAYLVYSEDIERFIVTECFRELEDRGHKVCIEAKDFLPGSFIPCNIVSAVQSSTFTVLILSAGYRDNEWFEYSLQMALMEEATSRRQVLHLFLYDPMQDAQLSRDLLRLMRQDAYSEFPPPDSQPEVKKVFWDTFSRFIGHTDNPELFPRLELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K563</accession>
    <name>A0ABM0K563_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitric oxide synthase-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101860365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NOSIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109012.1">
        <property type="nucleotide sequence ID" value="XM_005108955.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860365"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16661">
        <property type="entry name" value="RING-Ubox1_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16662">
        <property type="entry name" value="RING-Ubox2_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitric oxide synthase-interacting protein zinc-finger" evidence="6">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005109012.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32636" checksum="0D6CE9BEA627237D" modified="2025-10-08" version="1">MTRHGRNCTAGTVYTYHERQKDTKASGYGSKSVRFGKDAIKEFDCCCLTLQPCKDPVITEDGHLYDKEAVLKNILHQKKEIARKLKEYEKQKNKTDKELQELAKAEQEAKASKFKQQESNPIGEKYLANQAAEQKGKMSSLSNVEEGRDKKLPSFWIPTLTPQAEATKIEKPDEKVRCPMSGKVLKFKDLIPVKFTPINDRDAKTSVISKTNRYVCAVTNDVLGNSVPCAVLRPSGAVVTVECVDKIIRKEMLDPICGKKLAEKDIIPLQRGASGFTSAGVTLEAKKAGPTIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5V1</accession>
    <name>A0ABM0K5V1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Betaine--homocysteine S-methyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109436.2">
        <property type="nucleotide sequence ID" value="XM_005109379.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858580"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005109436.2"/>
        </source>
    </evidence>
    <sequence length="350" mass="38385" checksum="7DA01B61522E7FF7" modified="2025-10-08" version="1">MPGQGLLQRLQNGSNVMVAEGYLFEFERRGYLKAGAFVPEVVIDHPELVTQLHEEFVHAGSDVVLAFTYYGHREKLRVIGKEDLLEVMNRKALALARDVAWATGTLFAGNICNTTIYRQGEEESNKKVAAIFKEQVEWATEAGVDFIVGETFGELGEAMMALEAIKMYGNGVPAVITLVPAGRGATYDGVPFGQACRKLEEAGAAVVGLNCGRGPGTIVPLMKEIRQACHGPIACLPVTYRTTESHPTMQSLIDPITGERSFPYDLPGQTCSRTEIEKFSTACRELGVTYVGLCCGNCSHYMRIVAEIFGRNPEASKFSPDMSQHYMFGDKKKFSDYTTKGMVEYTGAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6F1</accession>
    <name>A0ABM0K6F1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cannabinoid receptor type 1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005109838.1">
        <property type="nucleotide sequence ID" value="XM_005109781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852211"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="44"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005109838.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39383" checksum="517B2CFCE5A9645A" modified="2025-10-08" version="1">MNVTSHDDPSDVTRPVLPVSLLQMLQHIVVVYVGNPLTLAGSVANVINIVVICRLDHRQTVNISLLAMAISDLVVAVCTLWLCISHSPLLYFIPDLPFIPQEISLPTGSWVHVTFSRITAYLTLLISAERCLCILLPMKVKNLVTIARVKAIIVVIFIWGVGSQVPILATNRFVWKFIPARNRSLLGLIKIDSSDDVQVVVHMLTTIASQFVVFFGVVVCTTILVLKLRQQAKWRQSSSSTEASDIASKRDARVSTTVTVISAIFVVCYFPNTINFVCVTTVPGYNLFQRYHALLVLVSACTFLLEAFNSSINIVVYYKFSSQYRRQFRRLFGSCFRLVSPRETQQEQKTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7D8</accession>
    <name>A0ABM0K7D8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TALPID3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110510.2">
        <property type="nucleotide sequence ID" value="XM_005110453.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851772"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029246">
        <property type="entry name" value="TALPID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15721">
        <property type="entry name" value="KIAA0586 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15721:SF2">
        <property type="entry name" value="PROTEIN TALPID3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15324">
        <property type="entry name" value="TALPID3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="39"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="606"/>
            <end position="642"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="855"/>
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        </location>
    </feature>
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            <end position="951"/>
        </location>
    </feature>
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        <location>
            <begin position="1053"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="396"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="57"/>
            <end position="82"/>
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    </feature>
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            <begin position="135"/>
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    </feature>
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    </feature>
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            <begin position="1053"/>
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        </location>
    </feature>
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            <begin position="1295"/>
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    </feature>
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            <begin position="1440"/>
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            <begin position="1481"/>
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        <location>
            <position position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110510.2"/>
        </source>
    </evidence>
    <sequence length="1499" mass="164792" checksum="0176E24007793508" modified="2025-10-08" version="1">MSVKSLDELVNVTGNAVMSLDRSGSSSGVSEKILTQFVGSAGSPFESPRSQSSHKSSQKEFKSKDSGIEKSGSKVTEVEKKTAQTSMENDNHDTSEDVTENDIQNSRENATVIEITPMPQGDRFFPSHQSFPRGLESHAKKGSDDTGKQDSNHSQEIDCAKSHSDIIVDDLDSKKNQTRFMSQQRHIRIERHGEFTSSFQHANSKASQEASSGGKNFVEEDRFSASDEQPEIIDVHEQVVMTSGMSETSENDSTENVIDTVIEANHPLARGSEERMDTIFKAHSAHGLKQGALSRGSVDPTKARVFDDVYISQFGLSDRQRDLKEALGKRSQNSKPRKKIVQPHIVGSQTGSETDSDFGMDQVTARTRGAVDETAATAAVAASAAVAATQPFIKAQQELESRMQQLLSQLGGLQEQKDLSAPAGLSSGGGDSRVDDLERQVKELNERRLEHLETLQQQQLQMQAQLLMMSRSKSPSDRMMGQSRRQVSPSRQFQSSRIPQAVTKRNNGVSLAQQQPALADPDVLFPYKSTVTPASKQQQPLMYSRDLMEKQRSYLNEVRELQGSHLDTPAPRQKVPTPTPYFLPENTRNNLGFLEELLAHKRTPERDTTFSVKGGYTPPSKLERDMNNSARTRRGDKSPVDQARKLMTSLTELEKETADSVWGPKGHGKDGYLMDVDLGPAPLEKYLKYPENTSSPYPKLGDARAEQKTSTRRSTSDKLAEAKKVLRQLETTRENLEENLAQVIRSRQDLHVFSTLLAPNHDGAPDERLKIERMVNRKIKSLQSDVQRDVLRGLAQREAEKIAAAEEVARQKLLAKKTVTSARYDNAKSGTLKLQAERSARLAYSKSAAVASTSVVPSRGKENRASKVKPPPKPVAIKDEKTMTRTYGKPEYQRGRTTIRDPYLHFQNTKKGVANRSVMNESAAVSPVGRGRSPGRSRSPRSGQNQGYGVTSTVPRQFYFSPTRGYIPLQEGAKAPIQGQLVSMAIPLGEPRLEPGVRQSATPIRPASNPVTSTPVPVTAARNVAMVSFPVEEDQNKTRTREPELAKQVLPPIDIDSISPSSSRRSDIQIRSPQQGNANVTFLQEVHDDDVDLDKTITEEDSDLDQTGEGIQLPGYEPRVAEYSGPSFPPKTGKSGPDWMAGGEQMQPPQQISDVMAEDLRRKDVLENNAVYWLEQELMARVLTEVMPIQVAQSAPLEAANISKAGSVHSEEASEREDSLLVADMIGHGGLQLFIDAGQPVDNNLVSALVKEVIQERVNSMLAQRPAEGADAVRAKEEIETVLKEKEREAGTPQIPTPEPTPKTSPIPSPRRLKQHATAPTTPPISPPPTGHVFSQRVEPEPLVEPVRAPAPAAAKPRSPPPQPEPEPEAVPTAPPAAVDYESESSVSIDISEELRRVAASGKPKHEEDLPLVQRHDVATPPISPPPMDEEEVQVPAPVSQRQATPPLSPQSVVSREPLPPSSPSKTQAPAPVESKAEKEAEQEEEEEEEEQEEETEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K821</accession>
    <name>A0ABM0K821_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC101856225</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101856225</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111004.1">
        <property type="nucleotide sequence ID" value="XM_005110947.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005111005.1">
        <property type="nucleotide sequence ID" value="XM_005110948.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856225"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF905">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="87"/>
            <end position="1443"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111004.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111005.1"/>
        </source>
    </evidence>
    <sequence length="1446" mass="156139" checksum="232254AC0B390EA1" modified="2025-10-08" version="1">MGIPDEMEGPPRKRSRLSLRALRTKDVPESAQDSHDVDLLQDSSGFTEPTMSSMPPQSEGNETSSEDLLLVPDCSPVSKECLVPPVASLYNLGNTCFMNCMLQVLRYTPGFVPALRQLQEEIVLEEIRTASESADPDDISEAIDVEPKAVWQFVKNAHQLFVDMEWTEDQYTDLATGDGVSMSVRPTALLSSIQSLNPMFEGHFQHDAQELLRCLLCYVEDAERELRLIRSRRKEEEEEKKKQESRQSDGGVGKTADSAAQDESEKDTLRCAKTGVRSELTGKPERLESDGETLRGGDCNDGARGRGRVRGGRGRPRKAGSSSSLMASSAFMETFLRCKTLKSGASVSGLPDSSSCCREGGKVEMDACDGGTVDGLQQSEAVKSSILKCDEVVTASGDLKGDSAHTSVEVEKKRATKGSCKKQEKSDAGKRENCDLEVSSKSRKRKRSISPGLKSESTVVRGDGSCPTCGLSKSGKKGRGRRRSKGKAKTEVCSCANTSAMVSEGDDKNVLDSAGADLSEKLEKCPGDVRVDENSIPTADKSESFLQKIQRKFQFPFSSTKGETSTSSGSRGLVGTKIESGSSQQRSILSMFPLGQVKRLGIRGRATVRGSDISKGNIESVSSQPPSLSAVKEEPNCGSESSIVGETSKCLSWNADKSSGPPISNATNCSDSSFSTVTNGDSSQCEAGSSRVSSSSSSCLRSPKLTPQKSDVVLRSSMCLTPRSPMSVAHCDEISPAPRGCVSSAASPIRSGISPPSTPRRRNLTKEFLSCSPTAKREEQTACYSTLATSPLPGSDITVHSPSKMGGLRAVKMELAKAKVSSSDSSSLGPLTVSTTFTTLPTRVSWPTPPTSRSSRYCSSAPNSPDHMATSPPVLSSSLFEERPQLTSAVHHKSGKASQGSLKLEVRKCDWLGVSPVKSISAQRALAVMRSESPKNLKTRPLKCSAVRKICYDEPILPSETNQKGKLTDECKEVGGSMLSGQKSGKFKTLSKSVEKLNQSGAVVAVPEAVDCPSSASAEPSAVPTLKTRRNKNPKKCHSGSSTDKKSSKLSSVSVSLQRCDWLLSDAKRETASMKMLLRGNKCKLSQGNSGSELSESKASPNRSCGNQIQSKNDLLSSSSSLLSSSVTVAEQLFAGSMVHCTRCLDCENTSDRQEAFMDISVPVRGDNPGDDDSDDEDNGGKTENENSSTSVSCLSRLVQAFSSVERLRDSNKYWCETCAHYTEAERSSRYTTLPAVLTLQLKRFSANSGLFGGVSKLNDRVGIPQILPCLHHNCQENCSQPAHQYSLFAVVTHSGLSILHGHYRAYVRVQPGVSPRVLRGLHRATVKEESETKDVFSEEKVETHRFSREKISQHADWLCSQNDSVSLVVEDDSSQSNRRRSLTKSSGDDDDGSLSGGDMSCLWLECDDECVRVLEEDEFESRLNETDGALMGTPYVLFYHKLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9A9</accession>
    <name>A0ABM0K9A9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADAM10 endopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101845373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase of broad specificity.</text>
            <dbReference type="EC" id="3.4.24.81"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.81" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005111940.2">
        <property type="nucleotide sequence ID" value="XM_005111883.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845373"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049038">
        <property type="entry name" value="ADAM10_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21299">
        <property type="entry name" value="ADAM10_Cys-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="8">
        <location>
            <begin position="379"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="7">
        <location>
            <begin position="529"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="801"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="841"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="872"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005111940.2"/>
        </source>
    </evidence>
    <sequence length="890" mass="99562" checksum="ADE1563225DEF54C" modified="2025-10-08" version="1">MVEFLSSSGLKLSLLRILYSLEILHLFVAVHYCGAEKLDEYILDYQRLSLDNLHRNHERVRRSLDKTLRINFRAYNRHFPLLLKPDRDIFSPDHFLEDGPDFAAPVDTSFIYSGHVQGVPKSYAHVAIINGSMRGHVHIPGDTIYHIDAAEQYFDRPSFHSVIYPESRMDKDPFRHKRSSESLGSCGVDHVKDWMDRVARSAVPDADTSHARRKRWTEEVYHTESESPQSKYFPGSRRPPHNTEQEPKGQSKRKKRALLGLNNTCFLYLRSDPMMWNFVQNEKFKRKLTDERVKEEILAFFASHVSALKNIFHRTVFTTYNDDLHYSGVNFVVQRTSIMTPENQRCGSPAASSYCNPNIDVSNFLNLNSMDKHDEFCLAYIFTHRDFTRGTLGLAWVGAREVASGGICERHRSYLERDETVPKSLNTGIVTTVNYRKAVPARVSQLTFTHEVGHNFGSPHDQGVDCAPFGSEQPNAHQGNYIMFASATMGDRPNNDDFSTCSKDNITRMLHVVINELNGKRNCFKPSKTAFCGNGIKEAGEECDCGYQLDCEDRCCYGRGSEEGEQCTLKPNVKCSPTAGPCCTSECEFVSASDNMECLPSDDCKSSAYCNGSMAACPEPKLEPNGTTCNEYAQMCHKGECVSSICERIKWKECFLTASPGDEGPSREALCYVSCEHPRTGQCVSSHDLGAVNKPENIIFKILLVNVTRVRSGKLSATEPEGIQLPAGSPCDNFRGYCDVFHKCRGVDADGPLARLKNLIFDPETLENIQQWIVHHWWAVLLMAVALIVVMGAFIKVCAVHTPSSNPRKPKHRQLTLPRTLQRRNRQRRQQQQQQQQPSSSGGGGGRSVPAGGGGGGRSVGAGRSVGGGSNKPTTSEVPHSSQIPEVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZU78</accession>
    <name>A0ABM0ZU78_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101850126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012934555.1">
        <property type="nucleotide sequence ID" value="XM_013079101.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850126"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026673">
        <property type="entry name" value="SPEC3/Stum"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676:SF7">
        <property type="entry name" value="PROTEIN SPEC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15795">
        <property type="entry name" value="Spec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="983"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="756"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="849"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="918"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012934555.1"/>
        </source>
    </evidence>
    <sequence length="1218" mass="133299" checksum="20CFA6BAA983F9D4" modified="2025-10-08" version="1">MSAGSSYKATGELTPVERTDRVSVPPTGAPDHSVSSPPKLDSETSVKSILVQEGTDNVAGDDNSTATSLKAQSEHCDPIESAFYQISDHDVDQGGHSQTGSHELNNCVFGVGETEKDNESEKRIKSHYRSNSLLSEAEEKIGMTNTEMEDEKGRQIIKDSEMSSNRPVSPTLSILKRQNEGLWDTQRGVETMHQGEGETLPPTSGVDVMSSLDKDPDASDTKGSNENLKDVLPQKDITGALIYSRAGTPTTELTEKDGSHNSDNTTETITGQTKSISNPLSLNRRDSVESSYFALFENESAADDIFYQNVRTSVSEVTKDELKGEQTNERVDKTDESSAVLDNAVLTESRNVSSSEDEENSDDSDYETNYNYREEDGKFMSTRENSPIDQRNSEKSHSGKPHVKFGDVIEEIISVTKLDTDDEIEKEALAHMDIVDDDGVNAPLKSLAPDNASPTSSSPRHTGGGSPNHSSRNGTREIKSSSDSAITIPSGEATGTMAADRDGRAWQDSRLDSLAEPEDQKIFRSTNRVNKRRPKKWCDEEDTHSAGEDFREREDDLKDLDIYSDDEADYRLSPNLDSGSDQDFPMKSPKRRAKPSMATYQSVEEMKAIDRLKVGPYSQSISAPNHKPKSPRRRAFHGATKSSSNKVRKSKQGARPKSKTSQEGDKIATKLKSKPQKPEETVAAAVKMKPAKTQRRKAPNSASEKTRLSSEVKKTVSKKTASGYIVKGKLSREDRSDSVENVATESVDDMEPVDTFGDKEEAKPETLLLKKEEGKLTPLKADIKKRSNEKKVSLAPATKADEKQNGKSANKIEGNPHMIQPPSNGSVHHHKNGIFNKNVSTTVTSETPIEDKINVEEPQEKKSRPSLREWFKSKKKDTPSSPKATRKLAAKYKTENTPRTDRSTPRADASKIIITVPDADKANDTESSKGKKEDKKHAKQSPNSTLPATITIVDETSDSVDANKTPETGKMILNKIKRKLNEKRLSTSTNSNVSLPLNGASRSPSPDTLHGSGNSRLAGRVAHKTQSMSSLQVPGPQTSGSPLAPPLEEDTVSLYSKRDSTLDSVSRKSVDYRIRNTTTVILPHTDEKPTKSVVANDETTPYLPLGLAVTCLCLNIVLPGSGTAVSGLSILCCGQPRLSGKTDQLMSTICANLMLGLAQLFTVTFLLVGWFWSIGWGFKLVALSVQHREEMKEQRAKELQALALSAFGSPKRATLFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUI3</accession>
    <name>A0ABM0ZUI3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane metallo-endopeptidase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101846947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_012934734.1">
        <property type="nucleotide sequence ID" value="XM_013079280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846947"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="122"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="576"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012934734.1"/>
        </source>
    </evidence>
    <sequence length="783" mass="89243" checksum="061EDA4E51AF78BA" modified="2025-10-08" version="1">MAMAKHSHFAAEDIAPLHRPGILTFIQNCLSEKSNKNNMSGGVKALLFVLVLALVAVVVLAVVIVQIRDDNKDTMKETSDKNKGDKIDEEKPPKTSDEICLTPTCITAAARILKNVDASVHPCDDFYKFACGGWLKNNEIPEDRSYYDVFSEVAADVNRKVKRILEEPPASDDLQAVTSARNLYQSCLDLDTMNNRGDQHFKDWLKANIGDSPLISTSWNEATFDLTDVVINATKQGSSLLVGIYPDVDDKNSSVHIMKIDQPGLGMPGQKYYLVPRNDTMLMAYQTFIYRVAETMGFADPATAQQDVEDIVDFEVQLAQVRIIRYLRRDAEALYNPMTLAEVHGNYSTGEFDFMRFVTSLLTAPEIGITDFTENETIINISPSYFRNFTELIRNTPKRTIANYVYWRVTMGFLGSLTQEYKDHRFEYYKVVYGVKTEEARDKMCSRYTRYQTGFAIGKIFVERHFEPEAKAMALEMIAGLQSAFDELVNELSWMDAETKRLAQEKNEVIQSKIGYPEFVRNDTYLEELYSNLTFTSDQYFENNLMIMKEGYGSWMRVLRKPVDTDAWFMSPATVNAYYYAINNEIAFPAGILQPPFFSKDFPKSLNFGGIGMVIGHEITHGFDDRGRQYDKNGNLEQWWSDSVIQNFKDKAQCIVDQYGAYVMEEADMNLNGINTQGENIADNGGLKQAFRAYRNWVNARGKEEPILPGLPYSNDQLFFINQAQVWCNLERRESVIQLIRSGVHSPGQYRVIGPNQNSEDFSRVFSCPKTSFMNAEKKCQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUX4</accession>
    <name>A0ABM0ZUX4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Teneurin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934960.1">
        <property type="nucleotide sequence ID" value="XM_013079506.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853530"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047197375" evidence="2">
        <location>
            <begin position="17"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012934960.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="34653" checksum="AB71815ECAD2D658" modified="2025-10-08" version="1">MLKTFVLFACAVTVYSLTHCQNDVDCHPPVCHDSAHAFCVHSKCECGNVVVGKRATSCSADHDCHPPVCGNSHHGVCQNGQCDCSTKQPDTTVANTTSSLISNSTSCSADHDCHPPVCGNSHHGVCQNGQCDCSTKQQDTTVANTTSNSTSNSTSNSTSNSTSNSTSNSTSNSTSCSADHDCHPPVCGNSHHGVCQNGQCDCSTNQEDPVVGKRATSCSADHDCHPPVCGNTHHGVCQNGQCDCSTKQQDTTVATTISSSTSCSSDHDCHPPVCGNSHHGVCQNGQCDCSTKQQDPIVGKRATSCSSDHDCHPPVCGNSHHGVCQNGQCDCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVK6</accession>
    <name>A0ABM0ZVK6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101846800</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935443.1">
        <property type="nucleotide sequence ID" value="XM_013079989.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846800"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="871"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="936"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="962"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="AGRL2-4 GAIN subdomain A" evidence="3">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012935443.1"/>
        </source>
    </evidence>
    <sequence length="1073" mass="118471" checksum="B65694445C4A9682" modified="2025-10-08" version="1">MGVQVGPVVAPPTVEESIELTSQLVEVTETEVSMEDVMVTSQLITALTTDSDGDKKPGEKKNKEQVEQIVDNVVQAGSNLVSSNKSALWEEMTTEDKVRSASSLLVAMETATVAMADEIEEETVIKQKDENIELELRVVDVETLEQEDKQELVYGSEQSENTFSIPVETLKSVSKGKLAKAVFMTHYSMADIMGGRKRGHKKAKGKKMPSGSPHDDPEVVRVGSVKERKTEMDTDQVYEEESNEEVEEEEEEEEEEEEEEEGGSGKDKDHHCHLSNSKKRCLDMIEVGCGPHGARMECKNDHGCGCHGVVSNPSQQGFIDAEENQRNLKNSEKSHHSNNHHHNHNETQHRGGAAEFTSISITLNDDPIDVKEEEAAGHDGRESEAEKGGVVGGGVDANAEELHSLLNHLNKGEGDVVLENGYLQTRHTNSGHNSMSSSMLSFGLDFNRHGDDDTIYDDDGLEDPDQGVPIDRGWAWMVCLGSFIMLMIYVGHNNVLAVLLLDIVSEMDVSIGTYNIMLSINGIAYCITTQIAANVLAPRVSVRVQMTVAAVVNVAATLMMVILPNFPVFFTMNVIKFCAHGFALIPSLTLVGYYFSRRRGLATSMALMGMSFGGIVIAPMTRFLKDEFGFRGCMLLLAGYEMHTIMASLVSRPLSRYRRKNKNAAKTTNPDNEKETATVYSHSSHPIPGDDVITLHKYGPSPYGSRKLPRSRMDITEISVSEITIDECQELRRAHPEPHQVSLLRQTLRHGLGSGRSLDYLKSRSQHSSVRQLGDYEDRSSISTGGRLRSVSMRQEDLHRSRRSLRDCIETRSVMAASVFGSSSVGLNILPATQMALESSDPDVIRRRTVGQTVCVCVKSLVEISLFTKPLCLMAMTMYSLTYAGYLTLTYLPAYATRIGITQTQSALLLTVSGLLDVGARIFFSFLADLQWVRPHIIIGITATVIGLITQFIPLFQTFKLLIFFAVMHGIFNSVGPSLYSVFIVDILGIEYLAKMLAVGSMATSILVAAQYAFLGAVIEATHSFNPVFYYAGTSYLVAALLVFLEPILRRLHEAQARKLEEKEAAARRDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW32</accession>
    <name>A0ABM0ZW32_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862635</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935739.1">
        <property type="nucleotide sequence ID" value="XM_013080285.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862635"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935739.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12182" checksum="651D430F972669D4" modified="2025-10-08" version="1">MTPVMFSQFRHLYEAYKDETLDPGEAVIVLFLFVCGINAAVLPILMALLVCCYCCFTMKRGLSSAVALRTRRAGPDLSPTASAQHNFLASSSTNFATTEVMGTVHPIYGTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW50</accession>
    <name>A0ABM0ZW50_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101861795</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101861795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935764.2">
        <property type="nucleotide sequence ID" value="XM_013080310.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861795"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012935764.2"/>
        </source>
    </evidence>
    <sequence length="159" mass="17514" checksum="4F5C2192C6B8A774" modified="2025-10-08" version="1">MTGKIYKEGERWTYGCDYNCLCIDGSRGLYVCNDVCKHFVCPASYHCTEYEDPDYACCKLLKIEVATLPPPSTTLAPTTTEKVKIGSITCPQYYNLPTETCQYVEDPSDPCCKIPICHAPDDTTQNPLQPVQLPSGGFEVTAAPGTSELGLLCLQQQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWK3</accession>
    <name>A0ABM0ZWK3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101858095 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935997.1">
        <property type="nucleotide sequence ID" value="XM_013080543.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858095"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935997.1"/>
        </source>
    </evidence>
    <sequence length="649" mass="70516" checksum="BF1A003000D7A1B3" modified="2025-10-08" version="1">MEECLRQMILAVKKRRDDLEYECSLLKGLLKPWPKEKTAASMSSQGKSTSLQWVTERNDGVPVEPHPPPQEPALTAVEEQALSQLDKILQKAAQARQSKGKLHKSEEKGRGPNLNATSGKRGEASGCERTASSQSADLGGTDVGKTQTQMSKSENGADSSKGRKSCGSRSNVTSLGKNVTPAATTDKGRSSSSSPMPLSAGRSRPASSSGRGRPASSKSGHIPAHMSAPFKTKPETAVRGGAHRKQTRQISQQTRLQRSGATSGLLLGNKTYKTLPGIKAKQGQVENTNAPLMPASSPESGGIYQPCPDTIQSGASGSPTQQELKYSSFDEIVGSSDSTGSERENAVRTCTTGHDLPCDGHDRARDTVTVHSKTIQQSQKDLVSDDRDGQDINSCHAAEVECPKSLDLKTIGPSLRLPARLLKLFSLNNSLRQKCRNAQLTRKVMPVDPAQHFVDRLRQSQCAPGAEMYHRAQALACLHEHNTLLDVLKDLNLERLSGDGESSPYEELVRAKTSLEFVLSKFAELEEKSTFLSQVQFRELPHEDLVVESASESLPVLLASQNLHHGPVWQMREPGLLGEQLAACSEWQELQFSLCRLELLAAVTRRAKSEWWPALEKENGDPAVLEAVHSLLTSAAQFLPAFVQNPHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX21</accession>
    <name>A0ABM0ZX21_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ficolin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936278.2">
        <property type="nucleotide sequence ID" value="XM_013080824.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011388"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936278.2"/>
        </source>
    </evidence>
    <sequence length="178" mass="20544" checksum="476586B6B46775AF" modified="2025-10-08" version="1">MTGLTNWRNVLLCLQRRASGDVDFYRGWTEYKNGFGNLNGNFWFGLEKIHQLTNQGRYQLRIDMKYKGKNYFAKYDNFSLSGESENYKIQISGFSGNVKDSMAAHNGQQFSTKDRDNDGIPSSCATWYHGAWWYKTCLRVQLNGLWGSTETAKGLFWEGLTGWKDSVSFSEMKIRPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1E7</accession>
    <name>A0ABM1A1E7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YEATS domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938874.1">
        <property type="nucleotide sequence ID" value="XM_013083420.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011974"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055127">
        <property type="entry name" value="YEATS2_3HBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22951">
        <property type="entry name" value="3HBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="2">
        <location>
            <begin position="398"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012938874.1"/>
        </source>
    </evidence>
    <sequence length="694" mass="73637" checksum="FD20B1358469F504" modified="2025-10-08" version="1">MRTSVDDRLLPVDESSPLLCSLSSPLPDNPVASSSSATNHAQVPTHPTNRAQVPTSSDDCVPTTETSVSSACVRSACVSSVACGGEREPGLANEEGGTLWGTKVAGTSSSLPQLSAPGRAKVVPGRQVSLLTGRVISPVAPRGDSGLTSAAPRASSGQTAAHRAARGRHTTQALNNVLGTIQHGGRQLLLVANTAAHTQRVNQTPTSLHPHTPPHLADSLPNSSSVPALRSQASTPLATVSTKPGTVTILQSFPQSVSQAAPIPPRSTCVALADSPRVVAVQQTSLVHARLTESAAAQSLLSNPASLAVSPSFEKMSAVGVTKHGKGVRAVPGVAINRSLRTDEERRLGQYEILNAWKNNPEKFSRVPSKSRKVCRSTDVIDGDVDHLPSLHLPDYLDVQSLTRAAVKLHPLLRPGVNRLTHPYCAESPDQWSSWPVGKQRAAEWHRACFTLRYLRECLGGRPHYQGEPLLSTRQLVVWCRRHGFSPCLTQATRGDTEATRGDTEEGVEGVVEGRVSQLLPPTLALSSQLLPPTFTLSSTLEKELRVTDRRTNDSQGGGDDQEIVDITEFTVETGLTARRGAAGGEHGQVTGSCESLSHGARFVTDLLRKRGLKLGPVELEAGLVTLTSADMIYRVAVEFAADLLREAAGVSATRFSRVLSVEDVHSALSSLPTAAFCRSSYLGKEADSDGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2L2</accession>
    <name>A0ABM1A2L2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Exostosin-1a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101851506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939583.2">
        <property type="nucleotide sequence ID" value="XM_013084129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851506"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF3">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Glycosyl transferase 64" evidence="10">
        <location>
            <begin position="89"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012939583.2"/>
        </source>
    </evidence>
    <sequence length="356" mass="41599" checksum="24AE74772F533FA2" modified="2025-10-08" version="1">MVRSVSQSKVLAMRQQCQLVWESYFSSVDKIINTVLEVVKNRVHKHQIRPSYHWNTVPGAHVVLPEWSDTPNHFPFYYGPLGERATDKFTAVIYATSPVTASSPLFRVLHTVAKSKFCHKVVVLWHCDVPPPPSHRWPADLGVPVRVKVRDIKSVNARFFPYAEIETDAVFNLDEDVILTTDEVDFAFGVWLEFPERLVGYPSRSHYWEEALGKWRYSSRWTNDYSMVLTSAAFYHRYYNYLYTHYLSPLLLAKVEECNNCEDILMNFLIADTIKQAPIKLTQRKQHKETAASGSQRTVLSEQQHFQQRQECMDEFVEHFGYMPLLHSVVRLDTMLFKDPVSNMRKKYRQIELVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2U4</accession>
    <name>A0ABM1A2U4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855574</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939702.1">
        <property type="nucleotide sequence ID" value="XM_013084248.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855574"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="45"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939702.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="38398" checksum="6FC66D2D0C64F506" modified="2025-10-08" version="1">MRPPGLDSVMASQAVANTLTDTDVCNDIDYLNFTISTTPTAGTGCTPGPLGMASGVIQNCQISSSHYSLSGKGPTKGRLNDVTGWSPFVHNGQVRKERYFQVYFGNKMLVSKVQLQQTGSAKVTAMAVGHSNDGVAWVKYPENVMSPDPSLSDETLDIPSPQVARYIRLYITDQDNNGRAASLRFEFIGCQSSTDGPSGPCQAADPVPIGDFKMRSFLVAAGTVYVCDGTQGDKGIQQRCYSSTDGRTWMDLDSRVGAMVGYESDEPRVYAVSADGMHYMTSADGVVWETGVPDDVTEAKTKATFSSALEVPVDGNPDLDGTPKPAFTQANYAATSVGLKNFNSVTWDNVFNWSTCCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A349</accession>
    <name>A0ABM1A349_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012209</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939864.1">
        <property type="nucleotide sequence ID" value="XM_013084410.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012209"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012939864.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21773" checksum="CD81027E491C7D68" modified="2025-10-08" version="1">MIQAVDYVMSATTCFLRKDNSSSNNTFDNVPYFHDGEDFLCPEDEKHNCTKSRRLDRLVKFSHVRRKDDLFPETFQQCLNKLLSADSPVPFPNTNNETNSTSVTDTDSHFAYDPHRKNILPEHYAGAAERGSGWGEGAFYLLNTVDDGRGHRIWSKVGYITCSGERDLKTVLWPGKSKRRHTMYTTNLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3N9</accession>
    <name>A0ABM1A3N9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein enabled homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940190.2">
        <property type="nucleotide sequence ID" value="XM_013084736.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849551"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="372"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940190.2"/>
        </source>
    </evidence>
    <sequence length="532" mass="57057" checksum="48C72CF4F7D90D30" modified="2025-10-08" version="1">MCMSTEPVQKRALLYIISCVCPQSRYKDEPNSRASSGRSSRAGSDYPDDTREQKKKFRPPCPGKVDTTQVVFCEPCHAQRFRIVLDTIRLAFSDDQVSSCPSSQPNPATPHNGSSPLSQSRRSPRPLTPSYPLSARDSMNRFQPQTPPTGAQMAKSPRYSGYGQAVGGNNMTTFSPNNPYALNRAPPGDQPGNVQGSNFQPPNWQAAGQAPDPYASPGVPTPQCGGVCPQQPTACSTGLAPLCPEAPVGFAAANSSPYPAQPLQTPMVPQQSLQTLIASQQSFHTPMAPPQYPADKFPAPAPQGFGPAPSPGQGAYPAGPPPGMTAESPAPFPPAFPAYGPPDPYAYHSPGGPPPPAQAGDNPRGQDPYALGNGNDKVLFCAPACLVQLDKKKNWREVYRGYLKVLQRAVGVGFSLLLESPDGVICSHHFISRDMTFEPSCKTQYGFCFSSVARCGSTVKGDFLVSFQGREQTDQFRQVVSECQRLLRLTAPNNTGRPDVCMGFGNSSNCNSNNYNNNNNNSNFGNSNNCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A403</accession>
    <name>A0ABM1A403_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipase maturation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101852779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the maturation of specific proteins in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lipase maturation factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940362.1">
        <property type="nucleotide sequence ID" value="XM_013084908.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852779"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057433">
        <property type="entry name" value="LMF1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057434">
        <property type="entry name" value="LMF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="LIPASE MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463:SF5">
        <property type="entry name" value="LIPASE MATURATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25179">
        <property type="entry name" value="LMF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 N-terminal" evidence="9">
        <location>
            <begin position="122"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 C-terminal" evidence="10">
        <location>
            <begin position="445"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012940362.1"/>
        </source>
    </evidence>
    <sequence length="659" mass="75381" checksum="51215188A1381085" modified="2025-10-08" version="1">MGSLYRTRDCFLWFMSLVYLFAFTSLYIQIPGLYGDNGILPAKLVLKTDVDSWQDLMEGQPTLLKLMPRFGLDVQTGMDLLCFAGMVVSFFCVVSRTARDFVSFTLLWMFYLSLYQVGQTFMWFQWDILLLEAGFLTIIIAPFNLQLLGRKRPVGNPHDSITMWLARWLLFRLMFASGVVKLTSQCPTWWGLTALNVHFESQCIPTPAAWYWHQFPEWLLKLSVVATYVIEIPVPFLFFSPVRSLRIFAFWSQVLLQMMIIVTGNYNFFNLLTITLCISLLDDSFCMFSQPKYKKVSSKKKSVAWSGLSGVANYLFPLVVLGYIGYQTVLLFNIKLNPDFTVHSKIAFSEQQFTRWLETVMPYTIYLGAASLGFEVVVSLVRSVVMERGAVRKLMCLAGTVVFSLFAVFIFTVTLVPHTTVHKPTQSALPKPVLTYHSAARPFHITSSYGLFRRMTGVGGRPELIVEGHASERAATKDWKAYEFLYKPGNVSAAPPVVAPHQPRLDWQMWFAALGNYQGNSWFLNVVYRLLQNEPDVLELIAHNPFPEEPPKYIRATLYHYHYTSPKDCAGKANCAWWKREKKAEYLPALAMSDKSFQDYLKHVKLADDDAPRKFRADNWLAKAIVWLRELIGQPEGLGFTVSVFGSAILVMFLNRALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4M4</accession>
    <name>A0ABM1A4M4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein lin-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101864237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940758.1">
        <property type="nucleotide sequence ID" value="XM_013085304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864237"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06720">
        <property type="entry name" value="PDZ1_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06793">
        <property type="entry name" value="PDZ2_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01208">
        <property type="entry name" value="PTB_X11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF16">
        <property type="entry name" value="X11L, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="159"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="250"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012940758.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37461" checksum="8A0CFDFC4E62BC4E" modified="2025-10-08" version="1">MRMMQAQEAVGRIKAPEGENQPSTDVDLFVSTEKIMVLNTDLQEIMMDHSLRTISYIADIGDILVIMARRRLITSPDDVLGRRRRQAKILCHVFESDEAQLIAQSIGQAFQVAYLEFLKANGIEDPGLLKEMDYQDVLNQQEIYGEELNLFANKDFHKEVIVPKSKNEPLGVVIVESGWGSMVPTVVLANMLPTGPAARCGQLNIGDQIISINGISLVGLPLSACQTYIKASRSQTVVKLTVVPCPPVVEVLIKRPDVKYQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVTLLASSVGEIHMKTMPTSIFRLLTGQDVPHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5J8</accession>
    <name>A0ABM1A5J8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ataxin-10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101861376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941244.1">
        <property type="nucleotide sequence ID" value="XM_013085790.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861376"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="6">
        <location>
            <begin position="61"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012941244.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18421" checksum="F768151CDCBD7D48" modified="2025-10-08" version="1">MAASHVRLYPGIQQDSELLKCAVTLLRSVNDIGKSGDNVFTKVEKASGLDAIDPHHPVFGLKKDLIRLVANMAFRHKDNQDLIRTLDGIPLMLDLTTMDCHNPFITQWVVLAIRNLVENNRANRDVLSGMSLQGMAGHMSTLREMGVHTELRGGKIVIKPVDDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5Q0</accession>
    <name>A0ABM1A5Q0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dipeptidyl peptidase 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941328.1">
        <property type="nucleotide sequence ID" value="XM_013085874.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860913"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="3">
        <location>
            <begin position="197"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="664"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012941328.1"/>
        </source>
    </evidence>
    <sequence length="864" mass="96316" checksum="1D6B9DF734C9ED71" modified="2025-10-08" version="1">MASELFDTYDLKVGSPPKPSNGHKKTWRELQNTVRETRKAIARLTPSVPCNFQFRTITDEFGNTITRLYFLGALEMGKDSTLLQADIPDTPLSQPMGGGDASSSQADSAGGDAWSQSLPALWASALFSSQPSGTAAPMSREEQLLRERKRLCSYGLTSYELSREDGLFVIPASNSLYVCHDSGDGAPVPTEVPTMTYGARLDPKLCPSNTDLLAFVHEADLWLTCLGTGKEIRLTYARNSFPSRLEEEYLSAGVPSFVIQEEFDRYTGYWWSPVCQRPSDGKRVYHILYEEVDESDVDIVSLFAPTEHDTSTDQYRYPKAGTANALSNLKLLEISLFFSGPTTQVTDIQVTERSLKPGLFQMCPWGEYLVRAGWTADGNYVYAVVMDRLQMRQAVLLISPYSFRSEAADGPAPHIQCIFEETTDVWINVHNCIHFLPQTSESEISFIFASEKSGFCHLYLITSKLRPQGVGFLHSGQGDGPESYPSQAVKEVVLTSGQWVVLPEQVLVDEARQMVYFMALKDTPLEHHLYAVSYSQPTPMTPIRLTSPGSSHSVHISEDFSKFVTVFSSLQSPPQSCVYSIQHTGPADLSFQPIGQLTPKTATLGYTPPSLFQYPSRAGHVTYGLYFLPRGYEQGRRYPTVLFVYGGPQVQMVSNSFKGQKLLRLHTLAAEGYAVVVIDGRGSSNRGLAFESVLKNQLGTVEINDQVEGLLWLASQTDFIDMSRVAIHGWSYGGYLSLLGLAQRGDVFKVAIAGAPVVNWEFYDTGYTERYLGLPQSNSNVYRSGSVLSYIHKLPEGENKLLLIHGLIDENVHFLHSSSLIQQLITHCKPYQLQVYPNERHGIRNHEASEHYKTTMLQFLQEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5V9</accession>
    <name>A0ABM1A5V9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101859117</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101859117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941424.1">
        <property type="nucleotide sequence ID" value="XM_013085970.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859117"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012941424.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28357" checksum="43C947D205424C25" modified="2025-10-08" version="1">MEDSGDDDGTNQFTQMTKTQLVDYLGARGLSTTGTKLALIGRAFVAWETGVTVKSSTETFQNQLKEDYKTTLKKFSIPDPVSLPPDSWSEKVTKWPPVDMGKIFMYLLSTSEYNRDYIGKYKTQKAYSYFASKFVGTILWAQVPDDCDRCFLTSEVTPSQSVRGDTHKQWILLRNTGEILTSMCSCTAGMCSTCNHVIAVLYKVEFAISNHLNSESCTETSCAWNKCTKKTVEPKRVEEMELKQRTSLSLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7G0</accession>
    <name>A0ABM1A7G0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 13 member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101855442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942313.1">
        <property type="nucleotide sequence ID" value="XM_013086859.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855442"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012942313.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="67890" checksum="662DA17D2831299B" modified="2025-10-08" version="1">MGDSTRLPIRHVIWGARNVIILVLTPLLLLPLPLCIGTSASKCAFVVLMMAVYWVTEALPVGVTALIPVALFPLFEIMPSELTASYYMNNMTLLFTGGLCMAISLEYWNLHKRIALKILLLVGTEPKWLMLGMMLATWFLSMWISNTGTTAMMVPIITAVLDQMRKGKNSTIEDVESNVAASDDQGKSHEVDDKTNGSVVDSSNAPHVAKKEEKPVKSQERYVVAGEGDQYELKKTESEGEKHDNDDAHSDASDSQEDDHMAQMERGMLLCICYAANTGGIASLTGTGPNLVLKAMVDELYHKHDLPSPVSFGTWMAVGLPLSAVVLIVCWIWLQVAFLRCRGPCCSCCSPATENSRRVKELIAAEYRKLGPVSLSQKIVVSQFLILVILWITRDLGGVAGWGKSFPSGFVSSSCPAMLMTIMLFAIPRNIPRIGQKLCVPLMEWSYVQQKMPWHLLFLLGSGFALAKGSERSGLSYWLGTQLEVFNDVNQWAVLFIIGYFATFLTEVTSNSAIANLLLPMLIQLALRTGVHPLNYMFPAALACSFAYMLPVATPPNAIVYATNKVKMSLMIKIGFVMNILAVPCLIVITRILGDAVFDFGNVPAAFSTDTESTQLAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A838</accession>
    <name>A0ABM1A838_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HHIP-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101846760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HHIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942641.1">
        <property type="nucleotide sequence ID" value="XM_013087187.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846760"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF75">
        <property type="entry name" value="ALDOSE SUGAR DEHYDROGENASE YLII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047432690" evidence="8">
        <location>
            <begin position="24"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="9">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="10">
        <location>
            <begin position="206"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="623"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012942641.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="83616" checksum="886D1FC53D06E1BE" modified="2025-10-08" version="1">MLSGAMIWTRVVLLVWLLPFATGHPQCLDFRAPFKPKTALTFCSQYSEFGCCGPHNDEDLAKEYDYIKSRATDSDWDKCNGYVKQLLCQKCSPYAAHIYDAEGTAKARTFPGLCEEFCENYYEQCRTMTWLVDEEFASTQLFSSKESFCKKVSLRDTDYCYPDLLTNPLLNRNLTRIQTSAPSEDCLCLEEVRDNIANPLWARHAGDGSGRLFVAQQKGKVRIYNIRTKEWNSETFLDLTDEVELSRFSGDERGFLGMAFHPDYANNGRFFIFYATDRERGDTPPPDLPGTYSFKIRVSERRVDSDNPDKADSSWEKVVLDLLQPYANHNGGELFFGVDGYLYVFIGDGGAAGDPLKAGQDKSLLYGKVLRLDVDSDTSQPYTIPPDNPFVSESGSRDEIYAYGVRNIWRCGLDRGSSDSDSNRGRVLCGDVGQNNYEEIDLLKKGANYGWNAREGFECYDDDLCGNIGPEELPITAYDHSVGKSVTGGVFYRGCENPALEGQYIYGDYTSSRLFSLKEEGGTWTNKEVTLCGSTLCDGGLRGCLRDYILSFGEDEDGEIYILTSESSGSSRCDGAVYKIVDPHTRNDPSECSQDPTQRGRVPLPARNKFTLGSLRKPTISIKVRKRKRLRQKRRRKLTRKKRRQRRKRRRRQRLQNGKKTPGIRKKNRKRRRQSRRRKLNNLGKGDAIGKSKKTGRRNQKGVSSQTRPKPPFNASQDSQSQGPKSKILKKKRNTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8X1</accession>
    <name>A0ABM1A8X1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101847838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_012943078.1">
        <property type="nucleotide sequence ID" value="XM_013087624.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847838"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="73"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="274"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012943078.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48329" checksum="46B3208CBB9E7A18" modified="2025-10-08" version="1">MAEDSVILDYDEEENEATVDAAGGDGPAKKDVKGTYVSIHSSGFRDFLLKPELLRSIVDCGFEHPSEVQHECIPQAILSMDVLCQAKSGMGKTAVFVLATLQQLEPVDGQVSVMVLAHTRELAFQISKEYERFSKYNNNVKIAVFFGGMNIKKDEEVLSKNCPHIVVGTPGRILALARSKALALKNVKHFILDECDKMLSALDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCKKFMQDPMEVYVDDDSKLTLHGLQQHYAKLKDNEKNRKLFELLDVLEFNQVIIFVKSIQRCMALAQLLQEQNFPAIAIHRAMTQEERLSRYQSFKDFQKRILVATDLFGRGMDIERVNIVFNYDMPENSDTYLHRVARAGRFGTKGLAITFVSDEKDAKILNEVQERFEVNITELPDEIDISSYIEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABG4</accession>
    <name>A0ABM1ABG4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein regulator of cytokinesis 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944497.1">
        <property type="nucleotide sequence ID" value="XM_013089043.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851771"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944497.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="73672" checksum="CFC186CADEE49E07" modified="2025-10-08" version="1">MDGPRSLSPTREQQRFAINKVVEASLKSLHQIWGEMGIDESQKKARGDMAVEHVRNLMGDMVKEEENMRNKFAKTVEDFTEQLNQLCLELALPHVKMAGGLTMVQQEKILRAKVETMTKEKNDRVSKYKELHARDLHLCESMSTTPYYVPSGSVPTLEQLKELEKHVNASQGEKDKRHAEFVSTKQKIVDLYNSLENDPDTSFGRDLLCEEDDTFVLSLPNMETLKSLHEELQKKNQEMKKEAAGLWDHLKALWNRLETPDIDREEFELNKEGHSKSVIAALRAEIETCEQLKFQNMQKFVLGIRNELVTWWDKCYFSQEQRNAFKHYTDDLLYSAPEDFTEQLLDVHEKELSKVQEYYNRRQHILEKIAQREKLFKEMIVFDEKASDPNRFFNDRGGKLLQEEKARKKLMKELPKVEEEVTETVLKWENENNKEFLVHGMRFPQYTVKQWDDFHLHKEEQKQSRLKARAKQTQDEMLFGSKTVLNTPSKRRVPTATTPLRTPLKARKMNDLPKTPNTTSRLPNHSRVQHSTMIHSPFSRQPLYTPKKTPLATSSSRKRRSIRLMKKAATERKATTSRRKSRESFSHTTVSSEDHGSTTLASTGTYNDFASGLSKPNCRSSVVPSGILFPLNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC65</accession>
    <name>A0ABM1AC65_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acyltransferase like protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944913.2">
        <property type="nucleotide sequence ID" value="XM_013089459.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013515"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944913.2"/>
        </source>
    </evidence>
    <sequence length="141" mass="15367" checksum="76CCD69E72A272E1" modified="2025-10-08" version="1">MRAPTNHHAVSKLYQQPIFLSYSNPQPQRFTEFYLTPYTRIGPFVVGVLAGYLMARHGGQIAMKWYVVVIGWAVAVATGLAVVYGIHGDITAKDPSSTEVAALYNALARSAWAVAVSWVIIACTSGYGGEKYCPRGFMHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACF3</accession>
    <name>A0ABM1ACF3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945046.1">
        <property type="nucleotide sequence ID" value="XM_013089592.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862693"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31328">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31328:SF2">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945046.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25384" checksum="32D8639954DA0FCB" modified="2025-10-08" version="1">MAKSGEEGDNSNVEPTEVETSDAEETESPGNANEGAEQGDAAANEEAAGVARAGLVGAEGGAAAQPEDEETGTLSMKDLYNAEPLHSNLYANAEVNVDPKVVQMLTDGFVQRFVPSLENARKTIEQIRSSQTVLVETVQQETSKFTDCKAKGDLEVTMDQAKLYHNKLVRLRREMTALHEKSARLKKRALRLQQQRQKEELTRAHDQEKEFEKERMLTAKVAAPSAPTSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACW2</accession>
    <name>A0ABM1ACW2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855609</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945273.1">
        <property type="nucleotide sequence ID" value="XM_013089819.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855609"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945273.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="31566" checksum="084BF08793AB9E03" modified="2025-10-08" version="1">MNPCDGQTCENYPDARCTPNYCTCKPTFVSGSGDVTSLCKNPPETAKAQTSTGTSTKTCASGVYVNCLTSPCKINSCGPHPEAECRDNNCDDCSAEFWIGDTEVTSSCGDTGPKISFGAIRKSASGRRPSTMDRVPPPADDTDTRIPFGPLLPTTGSGIGFGPRIPSTGSGIEFGPLIPNIPSPPKAQSPRKKCRNSCVFPPCMFRVCAAFPDAKCTNDYCGGCTARYYVNAEEVTDRCNAQIPSSTPSRRLGIFSRLRGRSNSRRQNSSPQEEKQQSRYFSPWSWLFGSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACZ9</accession>
    <name>A0ABM1ACZ9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylhydrolase ARH1</fullName>
            <ecNumber evidence="4">3.2.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ADP-ribose-L-arginine cleaving enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylarginine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101855153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.19" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012945336.1">
        <property type="nucleotide sequence ID" value="XM_013089882.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855153"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF26">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012945336.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45651" checksum="B5416D114B72AB92" modified="2025-10-08" version="1">MLSLTVSILHIWKSLQSVPGHMFYKSASASVDMESRYVSAMVLSGVGDAIGYKDGEWEFCHNGSRIFAQLQSLGGLDKIVVKLPGWMVSDDTVMHLATADALIESSREDDMETLLLSIARHYKQCMKDMAGRAPGNTCRLGTSQLRPAVKKGYRIPFNPRGGGCGAAMRAMCIGLRYPRPDQLDTLICVSVESGRMTHHNPVGFLGSLASALLTAYAVQGRPIQSWGQGLMETLPKALDYIRSSEYCVSENEEAWGYFEKKWQDYLELRGLTDGKSEAKFPEQYGFAERDQFVKSVSFSGWGGASGHDAPMIAYDALLGAGDNWSELCNRGMFHGGDSDSTGVMAGCWFGVLYGYKGVPNGNYSRLEYRKRLETAGEKLYKYAFPDADSEKDQPVMAEAVKVTVEEPAASENASSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD10</accession>
    <name>A0ABM1AD10_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012945364.1">
        <property type="nucleotide sequence ID" value="XM_013089910.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859994"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="54"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012945364.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="40976" checksum="0DA4611E7B9635B6" modified="2025-10-08" version="1">MATKMGLFRIAANQLACLLKQTSLRGTTASSTRCMHFNYVPETPSQDHGETARMNFFQSITSAMDIAMASDPSAVLFGEDVAFGGVFRCSVGLKDKYGAERVFNSPLSEQGIVAFGIGIALTGSTAIAEIQFADYIFPAFDQLRSEAAMYRYRSGDLYDCGKLTVRAPCSAVGHGALYHSQSVESFFAHCSGLKVVMPRGPIQAKGLLLACIRDNNPCIFLEPKVLYRSAIEEVPVGDYELPLSQADVIVEGTDVTLIGWGTQVHVLRETAALAQQKLNVSCEVIDLVSILPWDVETVTKSVEKTGRVMISHEAPITMGFGAEVAATIQRECFLSLEAPVERVCGHDTPFPHVFEAFYMPDKWRCLEGIKKVVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEG7</accession>
    <name>A0ABM1AEG7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synaptotagmin-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946130.1">
        <property type="nucleotide sequence ID" value="XM_013090676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013877"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF378">
        <property type="entry name" value="SYNAPTOTAGMIN BETA, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="61"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946130.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22585" checksum="21C0F30E0FF62314" modified="2025-10-08" version="1">MSTTSRSSMRSEQFTDDTSSISAKSDASVDSLVFDANFGAIRPDLYPRKDIVLQQSSLDSGHGRLHTRLKYDFRTCDLVVHLIEAQDLPAPDPVTGQFSDPYIRLSLVPCVDERVRQSSVKRKTLNPYFNEYFKFPLDFDDLKVVGECGEVLISLSYLPTAERLTVVVMKAKELKLSTAAPSAAWAVLDITSSRGVISGSEVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEN9</accession>
    <name>A0ABM1AEN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101852222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946235.1">
        <property type="nucleotide sequence ID" value="XM_013090781.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852222"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="418"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946235.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="66026" checksum="54716EFA4B1E6193" modified="2025-10-08" version="1">MNQDLCEESTTHVQKLVIGHTMDDSETERSTFVGGHDLNRGLGSGGSLTGSEETAMACGKTTPNGSSCAVLDQDVGKGAKKGEKTSIFGDVSNVLSVANLTPAWFAQSGLLSLVQTEYTSSSSELLSSAKSSLLVEALSSFDRSSVVETSSSPEPSPSVERSSSVDPSSFSETLSTKKEDEGNQASISPYSGLRRLSLKMSSVASSSSSMLPVPPPENNKTDKLNSITEHERESASAGESKPSDKTSPCSLVSAASSARPSSQQSVTRMTPRPCNVFVCSRINPEVRQKQDQGSSASGVAEGAARQTRPQRPRIVFSSLVNISLRLAEISAASIVKNVGRRVSKRPSSPSSCSNAALFLKTSTPPPLHPDSNDTDFSCVGRQEQFTQIQDRQAFAQLPIVTVSRMPPMPKFWEYKPLEFNEVIVVHAESPSSFVAIPEKMKTSLEMMEKEIEENFLSPKPHVICLCYKTLYTVKEKGYEQLMSIQVYYPDHGRFDTVFPPQLFQLPKRFYAMPFLAHRMGLGAITPISNKWSEASKFYFMSRVMNKIVNACVVPAPNSTEQDPQDEAKANPSSFDLKPLEVHLIDASGEDDEVIGDLLCLKGYARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF37</accession>
    <name>A0ABM1AF37_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mesenchyme-specific cell surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946463.1">
        <property type="nucleotide sequence ID" value="XM_013091009.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856157"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055188">
        <property type="entry name" value="Choice_anch_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052956">
        <property type="entry name" value="Mesenchyme-surface_protein"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038117">
        <property type="entry name" value="choice_anch_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928:SF1">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22494">
        <property type="entry name" value="choice_anch_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046921946" evidence="2">
        <location>
            <begin position="24"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Choice-of-anchor I" evidence="3">
        <location>
            <begin position="49"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012946463.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="64805" checksum="CE3A4137BE98CE32" modified="2025-10-08" version="1">MTSPAVLISVLGALAVVICHVQCAVQLTEVSTVYLPHTLTPTPRYGLGTGSVEQLAYHHETRLIYVTGSGVFHVVNATDPTNLVREFSIMTENVDFTDVAVCGDVVFVTVKNLQVKGRGQLQVYNLFDPVNREITLIRSIEVGSLPDMLQARSDCNTVVIALEAERYLDASGAFHDPEGAVVTVKFPDGPRGSAQPVVTTLDFRKYNQRFDMLEPSGVRFVYRDNNNSFSNDVEPEFVTLDEKSEKAYVCLQENNAIAVVDLKSENIEHVYGLGFKHWGHFDASNKDEGIQISYWPIRAWYLPDAILFYTFQGRRLIFSANEGDAKQYSDFDEIERGKKLKNVSSTVPKFVRASLQDDALLGRLKFSSVDGKDEQGNYQHLYTYGGRSFSVWDADQGMTQIYDSGSHIEESTALHCPHLFNMDGNDEQPDSRSDDKGPETESLALAEVRGRLYVFVGNERPGTISVYSFGSDLTKPRFETIFCDGIPDDSRTPDQRFADRDLFAVDPEDIQYLSEEESPAPYPVLLVAGTVSGTVSIVRVNITDEPGDSDPKPPSNGNTYAVSVWVLAASLLVTWFKTREITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFC5</accession>
    <name>A0ABM1AFC5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106014082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946581.1">
        <property type="nucleotide sequence ID" value="XM_013091127.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014082"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042621">
        <property type="entry name" value="TTC23/TTC23L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14485:SF2">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14485">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946581.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57064" checksum="0247E55E94E9BA6D" modified="2025-10-08" version="1">MGEERESVEEAAPLVPVVPVVEISRNERRSRQAWGSGDEYEEDWSDEEENRNNNNNNYDNDEDFDDVDDHAMPSPRRSPRRPASRSRFKSANGKRRVDMTPPDQKLKESEKLARSLAAEGKADKSIQEYIRCVAYSRIVYGSSHWRYAQSVGDLAQAYLDLKGYATQAEHHSETARSILLHGGHTAGDVEEKAQLYAVLIQVYRVMGQACTALKKYKEAEQALLKADKISSERSKLACVSDRDCDRLDILLFHAMARLYSKQKKFALGSTKFDKVIELMEKEYGTETPEVLGTYLDYGKMEQAKGRHANHEKVIQLFLQAHSIAAAIYKEGHPQLVDTAMALSEAYANTGWEEAEGSAVSYLEECVSMCTVSHGPTHPRTLSVQDQLCKLLVRTGRSEEALNILQSSLAHKCEVFTDYSQPVSDTYKLMASVYLSQGNLQQALRLYKKCYTIEVSLFGKSHKKTVDTQKTMELLMASPGLSKKFALSKQEELSNRPRFNSVVARCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPP2</accession>
    <name>A0ABM1VPP2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Anaphase-promoting complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101850873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824384.1">
        <property type="nucleotide sequence ID" value="XM_035968491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850873"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="62"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="9">
        <location>
            <begin position="681"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="10">
        <location>
            <begin position="1637"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1756"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824384.1"/>
        </source>
    </evidence>
    <sequence length="1951" mass="215179" checksum="0137DA3FD44031D9" modified="2025-10-08" version="1">MITCCDTQDFIPFGREYLRRHPGQFQVKRKCNSPVNEQGLPLIKSFKEISLLETTKKEDWVFRQRKGDNVFDEELYARGATVVWSRGGQDSVRKVVKTFTMDGPVLQALWGSFVLSSDENTMDSRSTLGASGKEQHGICVVESSTLSFFVEEGGDYVTPLPFQVSRTWQIKHGLLFERTLTHAERNTPKRNCPSQTVVFSMLHPLDDVAPVITRVSTGGGPPKVSYLTDTNLTLTFTCSDPSLAFTYDSVAGLHSVWRIRKVWGEEINQLSATAEGNSFLHMTPCLGASALNLSSSFSKQHANLSAGAAGLNNSSSFSPLRSFSSKIMSPGGILRASPSAGIMSSKLFFSSGIRRPHSPGMSTANTSALYRFQTPPQRSPNSLLRSPSSLLNTSHGGNESFYGMAAPAIQPCVCLELLWTEGIQQIRDGQLGKASKAFLTEDLCGQRYLCYLVPYKQHLRCLKFEESNDGSQLIFGSLSLLPAKDATPIESQNLLLVLETSGALILYTGTTRVSQVHIPVLPLGSGSLSLLRPMTPMGSPTRGEILTSSRPPSASAMDIRFEDEMKHISPVTAHLEDSTGGAFDSSISGILPVGNSFIQGLRDNMGKKFSVELLSGALCRTELPSMTDSPGISLCLRALKHQLPSQVALQVLARWYTVRNAPGGIGNVPEWAMFTKCILGLMGYDTGKLSLTSKGCTDGSSSPVLKSKKARPSDQGANQDWESLLESDHHSYSYPWQQALSLPHLEPATSGWTPSCPCAINSSALLYPFCPAVLMALHLVYEEMKLSILLQEELSGFAPLVHQIACDLRCWTYTDYYRRDFPELFEKVDDISQITDADLQKMQYPHLYPQQVPTVQGWLTESLNQSHSQQGPMIYIPGVCESVRKIISVYSILLNPEMPAELCVDKCLKKIAPAGHRAPTADTSLSYSMSKSLRMSPGYSQAERLVLTMTELDMTQRDLDCVPIGVSLPLREACLLCRANPPSDWPQSAYDLIGRQDLSELAALDGKVKSFHLPEPVPVEPEEEVEKEEDDGMDCLDEEVLKLRFPKDLRLQEVRRLLQSARPVVISVKQRPEVSDHDFIEEPERVLLNTCVRTMSLPVGRGMFTLHTCQPLLTETLPIPKLCLTGRAPPRNTTVDLTHIDVPANMSVWPQFHNGVAAGLRIADTTQVDSAWIIYNKPKELTNEFAGFLMALGLNGHLPNLSTFNTHEYISEGNELITIAILLGMSAAKRGSMDLTVTKALSCHVSALLPPTSTELNIAHNIRVAAIMGVGLLYQGTGHLPMAEVMLSEIGRPPGPEMENCQDRDSYALSAGLALGLIMFGKGNQMTGLSDLSMADILYHLMVGGHTKQMLWPLRERIYKAPSFLIKEGDSVNVDVTSPGATLALGMIFFDTENSAVSEWLKAPDTQFMLDQVRPDFLCLRTISYGLVNWKSVLPTPAWVDSNIPEIVKKYAFYRPPRGEEGELDPSIDLQTMSQALCSIQGGACLVMALKFAGSANRSAFKTLLDSVRGSMKLLTDAELMEQAGRSTVENCISIKLLALSVVMAGTGDLLTLRLCRALRRRVGPQHHQLAYGNHMCHAMATGLLFLGGGKYSLKTTPDAIGALLCALYPHFPLTSTDNRYHLQAFRHFYVMACEPRLVIPRDVDTHKFCYVPLRIKFKGCDAYKSVSFDTGSPYVIPELSKLEEVQVLGNRYWPITFREDKNWETLRLVLQKGGVLDVKQRAGHLPYMQDPKGYRGLLAKSLMADHSCHFSFKPEVIKSFTSDAKVTALAEFFINSHSIENSSLQELSAAIYQCVTQEAAEAICPHFILKQLSHQCGDRSLNTLGLAQLKLVLTYCSSQHRLVAPANTQNSLLRQEFLLALRCRVEAALDRWANDKPDVVAQYLQADEQTQLHETGSLAHYLVWFSVPSRAELMAPGLSACPPLPVLATMFPRLNIAGVMRLHSILMAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ30</accession>
    <name>A0ABM1VQ30_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C-type lectin domain family 3 member A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118477357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824522.1">
        <property type="nucleotide sequence ID" value="XM_035968629.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477357"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="107"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035824522.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26552" checksum="15449BC47F0ED9FC" modified="2025-10-08" version="1">MDKGGHPLSVWADTVVEERPIGPDMILDRMKEMDTKIKELDAKDKELESKINAIDAKGKELDVKENEMDAKIKTIEAREQEMNSKVNNFRTRLENSKDAIISATTSYRGHNYLLSKPILVNVHEANRLCRLYGGYLAEINDKQEFQLLADFSNSHESVTIDVMLGATDEGHEGRWTFLTSRGNMTSFVWEVSQPTGGTDQNCLYLSTTAKKMFDDACLKYSSSWPKRFLCEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ75</accession>
    <name>A0ABM1VQ75_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101851253</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824567.1">
        <property type="nucleotide sequence ID" value="XM_035968674.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851253"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF100">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="64"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="463"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035824567.1"/>
        </source>
    </evidence>
    <sequence length="713" mass="77338" checksum="035C649CD9B22CF5" modified="2025-10-08" version="1">MEEGQKVAESAPPSFSVTPAEDEAVQSENQPVSESVDEEDCETRCGYWGWRPNFLQSVNKPGFLVFFVAMYSMMLGFVVNGVNNVNVSSIERRFDLQSANVGFLASSYDISAAVLAVVIGYYGSGKRKARMISVAVFASALGSFVMTVPHFATGQYSLGISADKICVDETSSNSSCSATRSNPRLGNYFYVFLLGQLLHGIGGTTMLTVGISLIDDSVMPKKTPLYLGFVYGCNILGSGLGYIVGGQLLNVYVDFDTVDHVELTPSDTRWLGAWWLAPGIAAALQLVVSIPLSLFGAELPTSKEVRRKRISQAHQGQPSAAASTSVPLPTKLKELRAVWIVFTLLRNPCFVFITLGMTVEGMFLSGIAAFLPKFVENEYGISASRAAIVSGLAIIPAAAGGLLLGGYIAKRFNLNITQAIKFIILTSVLAALGSSVIWIRCKPLEIYGVSRPYHGRDKGQLPISLGAPCNNMCSCDTDLFEPVCNNETGVYFSPCYAGCTEQTGPNVFSHCACVSAISRPGNQSSVSQQLSSENCRQPCNMLYLFISLLFFSMCLSFMPIAPGDSIQLRCVEEEHKTFAQGIKMLIVRMLGSFVGPILVGKLLDLNCDTWRERCGQRLSCWLYDHDTLVICIYLFIVTCKGLSILFCCLALKFYQPPKPPVVEQVASPQQEMGNVAGHCMPYGDGHSAAGDDEEPDFSVEDDGSSRTLVRFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ95</accession>
    <name>A0ABM1VQ95_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor ionotropic, NMDA 2D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC118477378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824587.1">
        <property type="nucleotide sequence ID" value="XM_035968694.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477378"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="13">
        <location>
            <begin position="63"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035824587.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16157" checksum="4646D3C9132FCC13" modified="2025-10-08" version="1">MADGNWDGIVGELREGRADMAVSSMTIDEDRSKAINFSVPYMETGITFIVAIREGAISATAFLDHRFSLFRTFWLMWAMLFGAAVTTDTPRGVSSKFMSSIWALFALVFSASYTANLAAFMITKEEYYDLAGMQDWRVRMKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTH1</accession>
    <name>A0ABM1VTH1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Myosin-11 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101847586</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825712.1">
        <property type="nucleotide sequence ID" value="XM_035969819.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825713.1">
        <property type="nucleotide sequence ID" value="XM_035969820.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847586"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038834">
        <property type="entry name" value="CCDC175"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35347">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35347:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="762"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035825713.1"/>
        </source>
    </evidence>
    <sequence length="852" mass="98283" checksum="C10F835886286E05" modified="2025-10-08" version="1">MSIIEEVPGVNNAVQKLQELGGRMRSDDFGFKENDISNLDKIIEALNELEKERKIMREKLETETIKASVLRHDLKVLPGIIREEIMVAVNAARQSNTDALEDLQAELDKMNNNMAELETKARELERENAVLHPERELLRQQHEEIISQLNQKMADKATLPLNDRSMQIALNETRDKVRQANQDIVDLEDGILQLKEDLIQERTEARHEKKRLKKAVTDTQTKTKEQKEQNVEKKRELDTHQERLVDSESRLDSIRKSVRRYETSKNKLEADERALSAQLSKQLKLNEALRRRGADIVNENLKEQQEFETMQRQLNNKVKQYEVDIVKETERSSRLDQKRIQLHCDLKDKERLQEEDALYVQELDEQLQSVKRNLTEKAEDVGRMQTENVEMTEEIEALSESHKAVLAQLNKQIEEYREQLSKERKERLELQEVKDEIGKSLDDIKTSQQQFISNISEGIQDGKKKHVQLSNEGVQLQKDIREDEAVIDKLDQDLQGVQEKYEQMFSAMQTKVDNIEGGILFMEKDIITKKATIAERTPIFEELEVFFNKRSEEYDTMKKSIVALKNKKMGLEDAIKRAKKERDGLKAPQETLKSDLKSHRGQVMRQLKKQGTDTQKIEQEIFLAGCQLRLVMEENQKFEDACKKVEDDLADLETQRMENEKIKMMAQGDLQRQKSELTRKWQADNMMQEFFASRDEATAEAFGRLLDKTEKRETKIDEITGKLRGELEVLSEFLDNLSTRRPEVSESARSKKRPGSLHSAIGTVANANKHSSLPDSSSRLASRMSQAKSLDPRLSPDTVRTPKSLRFDLKSEAGSVVSKKSRTTRSPLQKFVPPASTTLEATPRSQGGKSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTZ1</accession>
    <name>A0ABM1VTZ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger BED domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101857339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825883.1">
        <property type="nucleotide sequence ID" value="XM_035969990.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857339"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035825883.1"/>
        </source>
    </evidence>
    <sequence length="763" mass="86083" checksum="8CA65C6440ECEBBF" modified="2025-10-08" version="1">MPRVRTRARTTKPYSSVVWRYFHVRDPSNEHLVSCILCGREYTRDIGGSTSNLLHHIKSAHADEDPPPIPESQRVRKLTRPVSTSDSDSESVPVKAKRQRTNLSFVWSYFVKPTSPHQPCSCNICGAIFKYSYGPGDKSTTRLWLHLKRKHPDEFLEGQRLTAERGGGGRKSSQSNVLKVSPKDSEDDSNDGEEDDSNLETVVLKQEPVVTKTRTSKATKTKGKRKDVTSSNASTSASASFKAKKSLEFKKKAYIDALVVQVITSELQPCSFVENENLRALVKSLDPHYDLPSYDKLSQEILPSTYEAVKQDVKLSLQLANKVAITVDSWVSWSSQQYVTVTAHFFSMSWDKKVLVLSTFQITNNMTAADTTAELQKIFAHWEIEGKICSVVTDSSSIISEAVQNLEMQQVPCFVHSLDRAVKEALKSAHDVVTIASRVRGIASYFQYSSYGVNMLKEIQVQGGNGPMKMLVKDEEARWMSTLDMFRCYIEQHEVISAALCFLSKAGDCITEGEVDIMKKVVETLEPFQLAANELCVENGATLSTMIPILKQLQECLVELHYQDFPLTAVLLRDINRLFLSLETNFIVGAATVLDPRFKYLSFDDPDKVKNIESRLTSMLSKMFESVSDDADDSSVVQEQTERPRKSLWNRFDSKVNDLLVASSPARNGPMIELRRYFESRQLRRQEVHPFEWWKANEKVFPNLAKLAQQFLAVPATSVPAAYIFSKDSEAFLAKRSCLEEGVIDKMIFLHKNYTNTNTVQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUH8</accession>
    <name>A0ABM1VUH8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable serine/threonine-protein kinase CCRP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118477816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826070.1">
        <property type="nucleotide sequence ID" value="XM_035970177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477816"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826070.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42829" checksum="5402F4773172C585" modified="2025-10-08" version="1">MLGQSERPSPGNVFPDRNSPQGSAGFNQDMPVFSVSSPWTSGFGHQRMELLADRGNWEVIVAARARQPKVKRVLKKFLLFEDDDHTSRMWKWSSFKHELSFLQSLEHHNIVRVLAAFQCPSYLGIAMGYHPTDLSRGLLDVTYSEAESYTSQLTDVMCYLHGQRIIHGDLKLGNVLLDRAGVVKLCDFGHSQVIPQDTDKPNGWGGTNGYLPPELYDSQVHNAFKMDNYSLGILLWALFFGTAPCDNIDYLNEVDNGWFLKPQHTHCLQRLLTLTSTLRAHIWEIAGILKDEDTSERCVRKGSVCSLSSESSSDSAQANQSSPDNGSSVTERPESAAVWNQFLAPPPPHPQATSCYLLPQTAYPDNGDITTSLAPTWPPLHKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUQ9</accession>
    <name>A0ABM1VUQ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 397-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106012014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826151.1">
        <property type="nucleotide sequence ID" value="XM_035970258.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012014"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF138">
        <property type="entry name" value="IP01201P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035826151.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="51749" checksum="DA279174A8E2C419" modified="2025-10-08" version="1">MGSREHVTTTAQSTRQQVSPGFVAASTMKDSNNNEASSLLRVSTTLTTISRKLTSRPDETDTVSDPSAHVLSDSDLSGRDLSSDPGHKGQAMDVSETHTDEVDVEEDTDVSLLDTSSDSDVTGSGCLEGESGRRHSGHLFRPWERQAHDVTGDKSSDIGAAKEIKLTTDISETQLDKMSSPVTSPRLRHKLHPPPATPTGKPLPPTSRLLHLTPPTLPHPFFHRDLQHQDTARHSWRDFFFPVKPLDHRDRLFKFGSSPQSIDNLKPSVWGQATGYLNPNLLFSLDPYKSRHLTFCPNSLLATQNPPSFFPSSTTTTTFPTPPGQSATSLSALSEFASTFQPHMTSLSHVLTSNYLCAQCNKPFSTPHGLEVHVRRSHSGSRPYACDFHGCILFPLSPGEKPHKCQQCGKAFSQSSNLITHSRKHTGFKPFACSQCGRAFQRKVDLRRHFETQHAMGGVLGAVDVGNLVTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVV7</accession>
    <name>A0ABM1VVV7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22 23" type="primary">LOC101847784</name>
    </gene>
    <organism evidence="20 23">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22 23" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005090198.1">
        <property type="nucleotide sequence ID" value="XM_005090141.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090199.1">
        <property type="nucleotide sequence ID" value="XM_005090142.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826549.1">
        <property type="nucleotide sequence ID" value="XM_035970656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847784"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 21 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="93"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="440"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="19">
        <location>
            <begin position="627"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="767"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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    <sequence length="868" mass="98408" checksum="7BFC72B7B49B246F" modified="2025-10-08" version="1">MAEASEGMEEFCDNFFKIKLTEKEFQSPAFERLLENGTLHRNEIEKIREEDEFDEREDLSDTKAGFSDDDEAQGGVDGHETDLRLRDYQFELAEEAVKGYNTVVCAPTGSGKTRVATYVIQKHLEKEEATNAVKKVVFLARTVPLVKQQYDNLQRHLGNKYSILKVSGGEEISLKLHMIIDTYDIIVMTPQILLNHLNFDLIPSLEILSLVVFDECHHTNKKETYNILMQAYHKTRMENGGEKMPQILGLTASLGVGNAQTIDGAYENIVKVCGNLDVRKISTVSKHVSELQKHTPVPTEENVNLQRRGLDNFVENMNSYMTKIEKRIKRLAEGLSCGGVHEELNMLPPDKKLQAYRQRIVLVRQAVETCKPQEDRIKDKGLLISLTRRLEVCSEALDLYDLADTQEVQKFLLKKIMDVPDENLRELPEMDPASASPNKNLQNLEKVLQEHLVEKSQSSRCIIFVSTRALAKALTGWMNRLNPSVRHLKAAVFSGTSASKDKDGTSKIEQNLLLKSFREGEVNVLVATTVAEEGLDITECSLVIMYNHVGNEVSRIQRMGRCRQFNGVSVLMAMPEDRPRDYLNREKAVLMNNALKDIGQKRQEFERKVKQFIEMELEPDIKALSSTSDVTQVPERILEFKCKICHRLAVKSCDLRLIHKMHRVVVNGDFLDNIELLYQRPKNVSELRFIAKVFCKEKECDNSIGTLLIYKYTPFVVLCRENLHCPSLKSNWKWKDASEKGCKCADIQPHDFKEYLFGNKDKWYEPPSVGATKQRRPPPAGPSVVPAPEADNRQVEPAIQIGQASNAEDTNCENGGIEGLGDLDEAQRILADAPPLDILSLTRQNVLSDFALHQTSFESDMSTLKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX59</accession>
    <name>A0ABM1VX59_APLCA</name>
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            <fullName evidence="8">Serine-rich adhesin for platelets</fullName>
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        <name type="scientific">Aplysia californica</name>
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        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        </source>
    </evidence>
    <sequence length="3350" mass="356620" checksum="2706541A3FA3896B" modified="2025-10-08" version="1">MKVKHVISSPTSAGPAPSSSASCSASAVGGVGGVGGATPPGGQAHHTRFPKLEEYAHFHYDLVEIPVLKVTLCGDEDSSSYKHNVDAADGPRMFLVTVTGSAPKPWMIRRTVDNFEMLDKQLHRCIFDRKFSHLEDLTLAQLEVKTRQEVQSILQSYLGHFSELAGGMVNCGSVLSWMEMDNRGHRLVATDDSGINTPAIAAAHVVKRYNAQAADEISLQVGDMISVIDMPPAEDTIWWRGKRGFEVGFFPSECVEVIGDKVPSAVVSRIPEPVASAAAARKPLMRKHGKLLSFLRTFFSHRPPRNQLKQSGIVKERVFGCDLGEHLLNSGHDVPLLLKSCTDIIEEYGIVHGIYRLSGITSNIQKLRLAFDEDRVPDLTEECYLQDIHSISSLLKMYFRELPNPLLTYQLYDKFADAVRDEDNKLLRIHDVVQQLPPPHYRTLEYLMRHLARVAALGHETEMHSKNLAIVWAPNLLRSKELEAGGGAAALQGVGIQAVVTECLICYSDIIFSDKMPSYGSQDNGNQKKPRPKSLAISTPTRLLSLEEARERAFMTHLAPSQKFIDVGGGPKNLPSKYHTVIDLPGYKKKVPSSSKENKPASGKKSSQTTNGTGNVGGGGWKSIFSKPRSGSVKKSRKGSGQEPVALGPAQAKALTEEDVHNWKRHLRSAKSAESLFSLSNSPSARSSISSRTSRSNVDNSTVGGKLSGKQDSTGAAESKALRSLAHLSHKRSLSSDASSVLHNRYRGDGTQVEVHHHVPIDVDDDEDLSGKQSFIRGDSSRKAMHHRRAPSAPNTPGQDRRHGGMERSSSLNRGETSGSDDMDLGLDDFVYPKSESRGDVNIDAAIKSRLLQVAEKNRSAKSNEELTLTSSPLKRSAKTPPKGRKKPKGSGHSHVGSSEDELSSPTNTSQLCPQKVIRSSSDISGSVGADISPYDNDDRESRMRRFYSRFHDYAEILSDDEAIAATPSSQGTMSVSSSGCNMQDVLDQIDSRLAMTAKLFPRQGIGDTSGYRVGDPPITRETVFSRSVETTVTSATSAASKETEFSVMAPSAAAATSSGLLAGSSRETEFPATCNTSPRELSSHQTNTHEHLGLDPDADTHRSLEGQSSSKLSPNQGGTEVSRRRVEISRADSSGRQGSSNSSPQHAASVTDGQTSSTSAPCSTRVVRRQAEFIPSSGAAGSNLEDLNTLLDNLENNGSPHRRTMDPSYPTSSNSVRSPEHRRQNASTSSSSSSKPQDDDVSSSQPFGSRTSPVFLPPGTHDGMMVATATSPGLAGMSKCLSVPSDIARSLENVTASQTDMMSSVTISELSMSVNSFNNGMGVDDHRGGPHSRAAGYGAMYDNSDLRRRRSTSLDSLGDGDRLMTRTLREINRQMDAAFKTDAPGDGSQDLAAAYNARDAVRHQRLISSDLDLSSSPETKMAGKGFHDPSSSGFWGGPGAGSELHGPREPRQEGEAWASSDSIVQLEASDQSITPTQSSADRFSLVSHLPPHHSLQPPPAAVDPSSFLSVRSGVPKSMSSDDSSLRSSSLVPGSSDGGLVRVLSDTLSCPSDISPTLTNVTPEFSPDAIYRQQHQQQQQQASLSSSSSSSLSQPSHVHQGKQFTFSTSSSLSNESDPFSPRPSDVTRRRSDLHDPRGAAADEETYRHEDGHIVAAPGTRSGQQPCGHKDIKSPISKTYVSDTVFGHRPSSQGQQSSSVGRSDVAYVYKKRSSSSSSTSSVSSKSSEEFDEVASPEEEEGDERQVRPPVSSNVVVPVSMADSGPGGEGNVKDNRRGLSLPLGGSSQNERLVGNEMQRQVGRGRGHPPAPLGNLHVDLSGIEASSSYSPPSSHSPVVRRQHSPRVSPRGMAGARAEPGLADSGAHEGSGRQQQQQQQHHFQQQHELLHLPSSPLFSGGPAGQMLADAETSERMSSLCAVGLMSQRARLSRESSCSSLQSPDSLTASCLMGAAAAANTRSPLATPVKEALPDIIQSTTQPDEGGGGVAGSDPGDQTGRSNVPLQLALYHPDEFSMDISAAVSGPPPAPIRQPSLHPSPSLPQVHTSSDTVMERKPTLRKSSTENAISAQLDKTPPSPSSSTSHQEMRESGTKSRSQPSEPSSRSLSNTTPATSSSSSSSSSLRKAQDPNLRALQDTSSPDSFRHRASSDSLTKNRTSNTAAFQDRRGNLRPDVGTPAFPDLRGAQAGPIAGQEASRRRPQKQQQHQQQQCHQEQHQQQLQQNQVERDEQVAMEVDNLCNKLVDDLNSPQSVDPPSDFPSEVLTARASQDVRTDVDEQGTVSMEVETSLEVKGSEHSSPVVQERRILRSSSDNGQNVEETRMVSVKGGATGGRGGGDMEEEEVQNVLNQGREILMSPDVSEGQGLSSSSTGRMGSNEAPTASRGHQQGAAAAAQLSTGGQTGNPTLDEASSSSSSASSSSSSSSNATTLPRPDSGIPVRKTSFSKIPRPKTGSDGSSTRTSNSATSSPNVSASRRPESASYPSSSMSSSMYADISLGSSSSPSSLKARRGSEATSGPMSKRQGHTRRASDTKVTDLRTVSPTSRSHGSPQGKSDSTSTRGVTSPRGRSSAGSDSRPSGSSASPQLSSSSRSSRIPMSHKIPSPQQSERRVDSSSSSSTSSSSLGTQGLSKQGSSKSRSPIPKPRKSSSSGSSGAGGGGGAKEAGVPPSEEVIEITRQSVKRENLTKSGGAASRDLPGRKDVDGGGRKTVVIKDMPDKGGAKLVIDTQPDLKKRIQTVHAKKVSQPPRQLAEALDSEDSGQGQGCERPSEPVVAASTAICRSPAESSVVATPSHSVTFSEEVTQHSPQTSPTTEGGGPPSNEERKKTPPPVAKRKFHYDSKSLPRRSKQLNNTQVSLVQQRTAAELYSDMVGSRSSLDDSVLQLAAERHDHFVPPGDSEAANFAYCSGSLRAKRSQKMQSLVNLFERGSDSNVSDSSGSPGTRHRDRTYSGSVLGSNGPMLTPCFEGRADLDVDDDPFLASSSSPPQVLRHSAGELQLSLSRERIPSYTSARSSESSAVDKENVERLAEGGHKRARQGRGSSGDMGGARPVSGEVGPSHQGASPGRKPSATDRASRQSGQPSSTPAPGGPTDSGILSSPATATKSSRPPRYRSNSKPRTQSESSTSESDTTHQIELTHSQTASATPSSRDSFPSAYPAVDSVVLRDSGQTPVKRERRLNHNRHSCDLPSESHRRDGLLSSSTSSVVPLSPSMSSSSSSSSSVLAVTSNSHTPPASPRRKSERRNSIKELRQVFERSESDPASSDVPLSLSPTSVAGFPSTSALPPPRPLTRSMSPQPDPPSGQREQVNLMRLSLELPPSAAIGSIGPTPATVSAPDARVQSVRLGPKPFYGAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZV2</accession>
    <name>A0ABM1VZV2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827945.1">
        <property type="nucleotide sequence ID" value="XM_035972052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858733"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="10">
        <location>
            <begin position="1892"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1178"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1361"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1441"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1183"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1450"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035827945.1"/>
        </source>
    </evidence>
    <sequence length="2180" mass="242681" checksum="21532A85236E5B2B" modified="2025-10-08" version="1">MTSLAAQLKKLAIPETQGVLSSGLQQASFLYAQGEAATYDKQHFYNIGINGLQQLIEKDACFEEFEQNLFAPSSQSLQRYIQTSEVNKQLDQNISRFLLQLSPYMQLRESHKAMEWLVHRYNIHLRNVDALMMCVLPYHDQDPFMRALRLLNMSSKECAMWRWLEPIKKGESFLPRQTLVTHCRSAKGFLGFICDMLAKHIEANTDDSGVPSRRRLQRVISFYTQTVLGVLMAGPPTEHILSTLIPSIGAGLRSRDMPDHMTSAYMVLSQLLVQTTLESSLLESLLNVLCKNIQPSLVHAAVTVVVLIFQRQAINKVSKKAFRYLTRQSALLPTLSQLSREANAEPFLTPFMSMLTQRALKESDDGGGVTSDSNTEDDDATPPSLLSLLLDAMNSVKLKEKTIIVVVRSVLDWFSKQRKESEMEVDGELSPSEGAFRVFRLLENRFSSTLESVVKEMTTSGESKGIGQTVKKLYKMSVQSAQDSLESDAASALTVCLHHHNEAVRKSAVERLLQDVQLMEDRTAIQSILVSRIQDDSSEVVMAVLDKPETLWELFEDKKLLEKTLCQKLLSLKGKAKGPTTRLVLRALSCIPFEVADDRKLLALFLSHLVPLALEDVTLASELLESSFVLCSKLLEHLNNKFLPVLKKLPSGGKLSAENRQNVTEKLVECVASYLANNSSQAAQFVQDIYNQVSSSPRPGSAALVLIMSCFTLAQRVKKAEMKMELQRVIVSLVVDVTLSQNVVSFGKSRSGPVMSSCLDQLSQDGRLSVEVVSYTLQELNLCPAPAGLKEAKFWDLWAEGSPERNWLVTLTSLTTFLLELSASKSPRVAEVARSIFPSVFKVLGDNASVMKFLCWMWTSDAKRGVTGADKARCLQFSQVFVSGLALDDRVKLTSDPAPTLPCLLLLLSSPFERVRGVAFTLLSTLTKDLSSETSNYKWTANSLMRYKEEVVKDENFLPQVLKNILESEDAVVSPPSPKKRRKSSSKLPPSSVALSFLMDVILDAATPGTVKVGLLRVLHRLDTAESFLQLPSVLASLIPTTDAATPAAVSESTLPSLSSEEKETIMLVLGRYTRAVASCVEEGSGSLSALQGALACPLKVRGQSDTVQIVALEQLSSKFMSGLQYECRRALVIQLLDMMSFTASTEVQRRSRKVIKKMTLEASLVVDELKMVTTKTSAGTVRESKKQRSQKKDEPGEMGLESLPWRRVTSLLELVQSKKKVTQAELMVPALFQLLARVLELEEEGSGEYVKQLVLGTVYNICSRQQVQGSQGVKGEHLNMELVVQCIQTSDNPHTHQQALLLLSAAAKIAPTLLLHNMMSVFTFMGANILRQDDAYSFHVIGRILENVIPALLTACEQKSKEKSSSSKSKKSSSGGVMGALGPEEVMTAVLRVFVEAMPHVPAHRRMLLCEKLVSVVGAARYLWRMVLLVLERITVRPSRTAVEEEGGEEGRGRAEEEEKTSGPVSVSDMEFLTSLCEEFSCSQLLQCFTQTLAYIAQLPEEKVGTTATTPSREGVSLEEMGPEDLEMFSVSQHSAKQLRHFKFAALYALRELVAGQHFVAQMSSLDPNSFLPDFQQLMETTLQFIGQVTVSHDKHREDSSARFWRILLHKSHDLLDGLVHLLPDTLFLDVVSGLMQHRLTLVQRRALELLNNKLVYFKENTAQIPVDLLTSMRGKLQATVKQSLLTGAVPGRKEEELVIGQAAMYGLKVLCRILGEKQQEDFVQVLDLCTSVLSRHHGNGVVAATAMLCIAEVVSCCKVHALTYLGQFVPLIVSQLQSEEITHHETLLLATMSSLQKVMESLPLFLSPYLRDITVQLCLISAQLDVSSGTHKPVVLQKVKSICTTVATVTPTRTFLPMLEKSFVALEKDMAACAACAMSMLREHVVKMSREELTTFSQDLLQFFLVCFDLRVTHTQIDESDLDSIEGCIIDAFVSLVFKLSEAQFKPMLIQLFGWATDEEASRDRVLVFYRLCHSLAEKLKNLFTLFAGHILKHSAETLDLNNKTKQKVKYFGKGKAARRKSCRLLVYVTDTLQQTFAHDTEGFVTKERFDVVMQPLVDQLENDFGKDSVCEERTSNHVVPCLGSLAAASQDDSLWKDMNYQILLKTRHEDPKVRIWAISAVDAFHKQLGEDYTQLVPETIPFLAELMEDESDEVEKHTQKVLAAMETSVGENLQEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W016</accession>
    <name>A0ABM1W016_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101858572</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828009.1">
        <property type="nucleotide sequence ID" value="XM_035972116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858572"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17685">
        <property type="entry name" value="RUN_RUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF16">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="RUN" evidence="5">
        <location>
            <begin position="147"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1206"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="798"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="839"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1134"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1165"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035828009.1"/>
        </source>
    </evidence>
    <sequence length="1279" mass="137385" checksum="5BE5E9DF260754BC" modified="2025-10-08" version="1">MKDDVLTLHIVEGGEGQQVSSDQSVASPTPRVQTSSPPRAAPPTPPSAPPTAPPTSAPPTSISPTSSSSCPSLSSSSSLCVRTHAGADRDTGVTEVTEVTEVTLMESSNLMLLRGIGQAADSLLQHFTQAKDPFEKLRLGSSVDCPEVAALVYCELCPAVERVVSHGLRDYEAGVHLFGKVRLSPWRLAEMTAELGPYTRPLHELARSVRQKNTLPSNRHKFYGFVAGLLNLRLLDFWLGYLRCKEQLVPRVYHDHACLRASLRGPLDACYTRLLRELQPLAVLPFQLEVTVIPALVMGDSVMVASVVDLDPPPTGPSPGNSESVVSEGRKDSAPSPAPASIATSTRRSGSWKWLRNPGAFSNALAHVAAKIGSSSPKPGHMTESGSEPKQEANVATDGEREEKKKKVDEGKKESEGGPEVEGGVTTTEGVSLPAVVRDHRAATRPHPAQQRDPRTAPRSDLSDLFLQESSAEGEMSDGPTPGPTTSDPATPDPVTSDLRPRCAVPEGGLELCPQRLRKYQVPRKISELSQALTLPNVEVIRTHAPDDAHTDALSDTAQGSEVAGQVCEGVGQVVGPRDDGAGQGGKDRTQLGTEDIPSLSSHPDPLPDADPNTDPNTDPDADPNTDPNTDPNPDPNVDLDPSAAIPQDKLSAGKPAGHRKSPRSAFSILSFFDRILLPQDRGKVAVVEEKGKEGRGKEEKEGKDKEAKGKDGRKKEVPEEGKRTEEKGGKGKDEKVVEEQRAREEIGKEEKEEKGEEVRKEEKDGETEGREEGSERASQRDVTAQGKKRDGDVCLTKSATCDTQGKSATCDTQGKSATSDTQGKSATSDTQGKSTTSDTDRKSATCDTHRKSEATVSVSKAVSSPTAGNVSKAVSSPTAGNVSKAVSSPTTGNVSKAVSSPTAGNVSKAVSSPTAGNVSKAAKSSASPEVVSSRPRLLDRGSRVVRGGVTLRDRSGAKIITTAGAVRNKTAEMFPKARPVSAFLERDLEESGWSLDSSTLARPLSLCDLPNMAAPLAGEHIEHVRAALFTDPLPRRHSPRTPTRTAHDAHMLSSTEDTQVWHTPTRQQALEKRQDWHTPTRQQALEKTQDWHTPTRQQALGKTQDWHTPTRQQALEKTQDWHTPTHQQAKSLPETETKEDNEKVVEGGEGRQPASQEEEGAESGGSSLSESDSSCGRGKSRGGRGQEVGETCQWDGRTEEELSQPEYRYVIAVEACHPPEGSEQLSFEQGDYLQVLAQVDHEWLYCTSGRQEGLLALTAVRPLTDHEVFETLTDNLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0F5</accession>
    <name>A0ABM1W0F5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein rotund</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101851829</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828148.1">
        <property type="nucleotide sequence ID" value="XM_035972255.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851829"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF96">
        <property type="entry name" value="GENE, 32687-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035828148.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="54099" checksum="48F242C2D45635B0" modified="2025-10-08" version="1">MTSPGAAASAAGEYTEPHQPPRCQWLNDQDAHFHHARRFQTSPLSYFKWSSKTDNHHHDPVSFSVPLGGGLGPHDGLHPGLNDLHRNNNSVGGGGGGGGGPLNHGAVGGGAGGGGGGGGPGGGLNYVRTASTGSLSGPPTPTTGPGGPNTPLVVPQPVKPPSRTGTKTYQCKICDQVFTTKSDMLIHCQQIHKQDPKPYKCPTCSKSFANSSYLSQHARIHSGLKPYKCEICERKFTQLSHLQQHIRTHTGEKPYKCMHPGCGKAFSQLSSLQSHSRSHMTDKPFRCNSCYKCYADEQSLREHIPKHSDTKHLKTHICHICGKSYTQETYLTRHMAKHSQENMPKIMTRPIKQEPMDLVDRDFIGARLPDKSTPSDLSMNPTGASSCSKGGAPSSAFMPLSPFAANTVSSSSGPGYHYSPGLSHNSLSSPLPHISSMASPRYFPYDPIGFGRKADAPDRNLNMGVPRESMIANSLLSLQHIKNYASQQMPSFNPAPTAGSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W114</accession>
    <name>A0ABM1W114_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12 13 14" type="primary">LOC101847843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828357.1">
        <property type="nucleotide sequence ID" value="XM_035972464.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828358.1">
        <property type="nucleotide sequence ID" value="XM_035972465.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828359.1">
        <property type="nucleotide sequence ID" value="XM_035972466.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828360.1">
        <property type="nucleotide sequence ID" value="XM_035972467.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847843"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021429">
        <property type="entry name" value="Mediator_Med24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12898">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12898:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11277">
        <property type="entry name" value="Med24_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035828357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035828358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035828359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035828360.1"/>
        </source>
    </evidence>
    <sequence length="1035" mass="117224" checksum="2EB3602D28B72025" modified="2025-10-08" version="1">MMSLPVKKEPGSNSSSGPGSVGSMLEVKKEPGAGVSGSAGVSAKAQLASKVKLAVVQAWRERWSEIQWSIQLKKLLAAYSGETVDIAEILMQRAVVGSTPVSLILSYLKHSVLSQMIPFNTVLKYITEFEDFSRPHCVLALLHLAEMFGSKISLSPCPDSALQLMRTMLRLIHWLLKALLSCLQRLQDNRPNQVASEYFVIIDNSSRAISNILERRAVRSLMQVARADSAEEYREFEQCEMNVRGTLTQLSPASMSEDTREKINNALMLLSKMEEQQLVLGPVLEVLHAPIYPTISGLVALEAIFNTNSDVQPFVDQILMVSRLMKLSMPQMCLEMFRACFMGFLDTSEYTEDLQWATFIFLKLPHILSTMRQQMPDWDVAIQVEKGIDMLMEYSHLLDQTDIKQNYDMLSQFINELHRANIISEAQKNILTQKRLEQRSKLRRSDITGSSDAKNLSRVSHAESTVTSILKAERMIKSLDSDPLKTSESMVKVLTIMHQGHSFDMLRLAAASTGRLGDFITKLIRMNEFASQNSGEALRIPNKSQLFDITFLMITSIFQQSGVEIAAPNRENEYTLVYQWAKRWLPEEGRYKNCEFTVVEDQDKVDAILNLLLSSSEIAPCGRVNSWKELIMYLPYALQEVLYALEHKAFGIDKVKSIIEHLRRQSTKSLVVVCTAYLCSYMNMVGAVARAKPLAMLEFLTAPQGAENKQPVQVIIDNIVFDILPEGHPQRPLRRYLLSNKKLSSEIMNETLKESFHRGWLTMCSLHTLEQLLALRGPDWFCREMVEHLLKQSHIDDMSQSLSLAFAIMHLDLERLTISLLQRVLPQLLTTPQTNTLTDPRGYCLAKLCVLSVTATHTSKIGQKDVYVRRLHKRTVVEADLEDDLDDSETSPAKLRKFSEPQLTFSLEEFNLEALAEKEDGEALPTFDMKEPLNKALVNLFMMMNTILLNHSLTPRTWFIVSFIQEAIKCGGQHTRFILQFMPQNMLNQLMRSLPGVFSDDHILHICDLSTVSGRKIAAKAICNNTLIPQLDIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1V9</accession>
    <name>A0ABM1W1V9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101848081</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828652.1">
        <property type="nucleotide sequence ID" value="XM_035972759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848081"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032060">
        <property type="entry name" value="MGA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16059">
        <property type="entry name" value="MGA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="2933"/>
            <end position="2990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1553"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1759"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1819"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2029"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2238"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2295"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2632"/>
            <end position="2654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2697"/>
            <end position="2735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2837"/>
            <end position="2859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3121"/>
            <end position="3154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1582"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1620"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1823"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2032"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2242"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2265"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2305"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2316"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2633"/>
            <end position="2643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2644"/>
            <end position="2654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2707"/>
            <end position="2718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2719"/>
            <end position="2728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2838"/>
            <end position="2850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828652.1"/>
        </source>
    </evidence>
    <sequence length="3154" mass="341715" checksum="FEC0A14AA5B7F2C1" modified="2025-10-08" version="1">MMARTKKQTLENASERKRQIQEEILRESLALKRDNPSGAQEVSLPKGNTVAVSSSSAAGCGKSKTCSSKAAGGYSVNGDSSSYKYGVRRDHHRYISSQVTLSSMSALARTSRAQSVELPKAVICIPDICKSPPKNMDEDASSRNSRESTPKRYGGASFVAGDGKDIRGSGKSGQDSSSRSKHYSNKNIFEQVQTEMSSKLKESCQKQSDHLRSAVNVSLNALKAASEQGRPDKVKKSRPATVSNSPDTLDNSKCKRPSPKSTPVGRRSPRQHSPGSRKDQQASPGSKLHKDMAADAVSEERPKVNIFTDNIGVDLGKRIRSPRRMSEDMIALPIFSARRWSNLPKDNNSVVPAGKNDSSGDGHDSYLKPVVSDSCFKSPSASPSSSRRSSSSTSPHKTLSPTAGSSGSDGAVVSSVNLRPPQGNQGASQPSQKKGNGEEDKVAEKKSKSYPLRKSKLGGVSQEIEPSEEGMVSLPSSMQKSNCIAEKTVECASDSERTSVQVKGSQSKGEKAKPHKKSKHKSEKHAEMEEVMSSICKEIIKEVVISKPDSDNEIEKMVKTEPADMERNDSSGEIVIVLPVCSREINSGSLALAKESLSNVAKVSQDHMSSAEPLPSEGKANENLTAASAEEKPSSLLCAMLVGGTEVAHTYTQEREKYKPHIPDVSDSEGNSSKGERDEIEEVPVSSGATTAIETPADCVNIKRECDDNQPGCSTSSVSFQQSVLNEEHSDCTAPFLDIKKDVKKESTNNVSGIVKGENGSGRLKSLGKRFLNRQKNLKIDFSSKLGELNESVLQLIDIDTEEEFVHNKWEVKASSDANEDTSAAEATKLYGLIQNLVTKLKDSAFPCNIPIDSDAIDKLVESCPKNALSAVVKFDENSRQDKLQKRLEEEAVKLKSVCSGKKNMEMDVEDGLNDSKQEAPVAVDKNVLNDRTGCEVSGHTDFGASQSSSTRNVFCGDKSFSGDSEGLRKDKNCAMAASSSSLDGSLCELDLDAITSAATSVICASDTGGCGEASRASSDIDCSELSNLGVKVPINDMQTSSLSGLSQDSVLRKSKTCDEFSGGGLRHHAALRRVNSSPQMNSRLAAAAVSAALSMPNLNNSPVKSKLGSKIPIPGASHVSRSSKRTWRTPRVIKDPTPLSVLSDLEATSDSRNIFVCQNLQKYLNTPSHRMIVPLVRKEEMEILDAKAKEEEERLEREMAESLEKGKQDKDEEARKMEEEINADYSKFEPDFDEVDGMLFMSFSSEVELEAHVRVERALDWDKNDTMLRISRAKAFEEAKLQNQDMQGVKLKHLRGQHMRWKKYRRLYSCEVKNLLDAKERGVPCKPIQHSRKTSDITKIKGWKKKQTSDISHFDSKENFIDLLTDYPQEEADQSLSTSFENDYGYPYYTSEGQMDEDLQFLGETTAEGDGTNDISPYMRRCKNFSHQKAHKQLFRELNMDWEDRMIHRKLGGWSLKGNRPKAFSQAAKKRQEKEARLTVDAANLDSVKDPAMDLSLSAALGDWNTDGSSADAAGDSPSGKKKKQIKMIYPLLSERMARNALRTLETGDIFNTRRKKKRRQLTPTTLPALTPIPAPRTPIVPSTSSQDHTPLDDTASTIGSTLAGSDLLSTPSQQPVITSQSKTPLTSSSASTATTPLQLDVKEEMVLEGVDVSAVPLSSPALSETPSSTPGRSCGKLGCRYGCICHLCSATEDSPVQAASPVSKPAARDCDKEYCRLGCICDSIDPEKPIPTQTHCRKASCMLRCVCQDSGVQEGNDDIPYLPSMKRRPKPGERFSNLPQREKTHRSAKNLDAITRKAMMLYETSEIYCEKVERTKKKTETASSSPNSSPLVSPAMSSAPAPSTAPINLPPPVVYTEIDDSDYLQDDSQTNTIFSAVNLLTSQETSVAASQVVVNSAPIVASVSSGAPLVPFSRPIKMALKIPKPTFVVDDVLQSAPVIEPSAHKRKRKSHPLSSEIFTNSTCARVHPYKYHMAVMEKSGRRHSEAPLTRDLNGSQSATSSLLSLAGSGIKISTSAEIGMMKTDVKAGVNSGSGRPQSECSQPVNTNPCQKASDVSSSLPTQTALTPGPVSAANVAVSQNMEQNQAQQSHPMPPQRQFHGWHTSMVCLKARAPAKTQSSGEEDVQEEDEVKLLEFAANCNWEGAKKEILSKVAQCLSRGHYPQPRTMNVCEFVVEILPKAHHPSIIPAELRVKLPGQMFSIRVRITRRDSISKSVKAPSVPVIDLSDNSPLKVTARAHSADSNSHSLSIKTSSNFLSSPSRDGPSSLPSSTPSLGISGLSQLCVDSTLTRQQQQQQLNLSSEGHVHTSPDLHKSSSAPNSRRSSLESFPVDTSIKSCKEEGANLQKGSIKTPKAADSVDLTIQGSTFVKVEGCSSVTSPSTTGSLSSENLVVTSTNKSVPSSKAATTVIPLASSLNVPNNMTPFIGPFSSKNIKYMKFPGNDTVMQVLEIKDKASKNKLIALPMALPNNVGDSNCVQPTVPVMAVPFSQSSQSQMVPILPSQASSQPLFLKIPMSHSGSNNTSQQILVQPMPCSVADGKTTTAGGQAVQLMPKKSTVASHLPDKVDSDSVVSLDLSVSDANSVQRSPEETIMVFDTTKIKALQQAKRAVQKSLAKDQNIVKDTHRAVDADSSLSSCPCDTNSSVGVSTSVTPSLSGPIVCTGVLPLRSKDCEENKEQESCSRSLDQWTGSDLKHDALSDSHLDPSCNSSKSNQENSRTVEDSDAERMLASSSNSSVAASANWDVIVTDAKKRSDVADHDADLSKPANGELEIVMGPESEGARSGGTKRPALDSELVGPRAKRVRRLGGDSNYQLLPVVDEDSNLSACSIPAPTCSAVPSPQLSTSDRPTSVMSSSALSTGSSDDVLVCMLSSDEEIDVGEDHPEAWYYIAENSARKYRETVERALQNDHVSLCSKPNIPHVVLKTSVNTPERVKNRSALERQRRFRLKLLFDELQNLVYLINGRPPDVLGQMSKAGVLSAAKQVILKLDEAEKRSRLEVSKQQHRKAKLEKKLAESIANLRRQNVSEEQIVLLLKNSVRQKTSAPSTPSVASSVQPSSTSCVEGKLENFLDVVNLVSPSSTDEKLSDRAVENVTPVYEDISEAEDSGAVALVEVKAELERGQSYEDISDPEEVQPKYEDISDPEEDKGQGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2A2</accession>
    <name>A0ABM1W2A2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calpain-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101856935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828795.1">
        <property type="nucleotide sequence ID" value="XM_035972902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856935"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="70"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828795.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="25017" checksum="15CD62F031B51D07" modified="2025-10-08" version="1">MNNNEFWKTWKEMSSDGEWKRPARAGGCGNHQTFLKNPQFLLEVYEDEEELLVSLEQEDRRSSNFRTRGENYTIGFSIIKLITIKRNIINIIVFSVFNYFVVFFIRTVHNFSGIEAYCILKCEDQEIRLSTTEKSNKPEWKDRVTFYRKKPTEDVVIEVWDSNLLKDELVGTLTLPMSKAHEYTGGNVIRRFNLVKKTGDDQEEHRGFLWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2I4</accession>
    <name>A0ABM1W2I4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA (8-3)-desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106013487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828877.1">
        <property type="nucleotide sequence ID" value="XM_035972984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013487"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF88">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE FAT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="9">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035828877.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23768" checksum="6A7A3A23BA3DB30E" modified="2025-10-08" version="1">MGDTLPVEKAKQTGRGWSVPYNLQSYYFFILGPPVTIGGFWPFVHTYHLLKRKNLVETLTVLAFYVHFGYLFGPMLGFWGTAKLLFMAKLCEGTWFITVSEANHGTLGVEYDAEDSWVEMHLKRTCNLGGGAFKSWGTGHLNYQIEHHLFPTLPRHNLHKVVPFVQSLCKKHGIYYCEKTFTQAVIDIVKSLRESGDLWSKTRAELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3L9</accession>
    <name>A0ABM1W3L9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101859292</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829262.1">
        <property type="nucleotide sequence ID" value="XM_035973369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859292"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046413405" evidence="4">
        <location>
            <begin position="20"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035829262.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="45564" checksum="D5B20FE74C5CD3BC" modified="2025-10-08" version="1">MVSLAFVCLVSCVFSGALTQTVTEAPSLSTSFRALAGAADTNNDGLMSKEERTADFKANFDTNNDGCIDSTEFLARFRALNFTTEFASFMFWSRVAQNGDLNNPVCKGFNVSRPIPVPVDFLISGNLMGLTVFCEQNPARYNGNSDCNQLPRACSLPTLGCYYSCFNYTLNIASQQLGPPIALPVLSQFQQNMPFEQAFNNLISTNDQNGDGVITPAEFAKDVAIYDSNKDGCIDQLEFTASLRRCPSLLPALNFTAELASFMFWGRVAQNGDLNNPVCAGFNVSNPIPLPVDTLLTFNIIGVTMFCEQDPTRYNSNSDCNQLPRACSLPTLGCYYSCFNYILNIASQHLGPPIALPVLSQFQQQMTFEQAFDNLIRTNDQNGDGVITPAEFAKDVAIYDVNKDSCIDQLEFTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3S1</accession>
    <name>A0ABM1W3S1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101846784</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829314.1">
        <property type="nucleotide sequence ID" value="XM_035973421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846784"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829314.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="49131" checksum="1D0A4AC6D09F350E" modified="2025-10-08" version="1">MEVHDPNKTEQLTKIKSLPNLRVLCKHSLQQESSAQCHGAAAIYRSSKPDRLISDELDKFRKLGIKCIVDFRSKTEYMGSDGHRLLDKEYPVFSVKIINNGKKNKGDVHYEYKRLLGATSEQMLVALATDEPSSDSGGAHENESSSVVRNRFDQVSPKQHGKDNVGVSNPTKQWQTYEEVGAMERKHFLINFFPFKFIFSLLFTLPWHLILMGFMLLFLDVIRRNKFKGFTKFFIQEAVNCKGIIGQYIDIAEGCQPSICAALKLVSDPNNLPVLINCAHGKDRTGIVSAMILSCLEMPKEYVAEEYALSNEGLAPIHHLVYRDIVEKYEFREEFCYSEAATMLKLLTYLENKYGSIQNYMVHIGFSLEDQKQLRDMVDAYDQREVGRCKGTTCRAPESGEGVSAVEGGSSVARGSDSVAEEAVSTVGGEGSSSLAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W402</accession>
    <name>A0ABM1W402_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Leucine-rich repeat-containing protein 27 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101857541</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945969.1">
        <property type="nucleotide sequence ID" value="XM_013090515.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829395.1">
        <property type="nucleotide sequence ID" value="XM_035973502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857541"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF35">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829395.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="61679" checksum="5741F19896803233" modified="2025-10-08" version="1">MAAETVGVGDPEGETEDATLESNFNLSREASDVDDAELYPLMNGTGAGSDDGETPADVPFAKTKREEEMILQLIANTKVMKSTSLDLSQKNLQTLPDELLELSHIEYMYLEGNDIAFLPDEFFKFFSRLRWLDLRNNQLSRIPSIFLSNHACLRNLLLEGNNLRNLPLELGLVKSLHGLNIAGNPLDFPPQEIIDKGTQHILSFLRMMMDAKNTAKMADLELNLSEEVHDGFEQISASSDDWNTTASMMDLAKKREGLHKVQSAEVTPSGGDHNQLTEEEEYSLGAKSAELHRPVRHSENKYKHIQKLKKAGALGVVDKKKKKQSKMSWKVNPYPSPPPQEYAAFRMNEEKQLARVKEFREKTDAILQRRKDDAMLKNWRDESKTLQQKKYTQNLLPGKDYEVTAEQAPFGVEKDRMKVLSKEERLRDDLRREKEIKDQRSVSPATRQRIEHEKQARIRDLEKRIKEHTAGMVERRKQPKGTPQHEMEIARRELEIVKNLQRDLMRRYQELKAWSAGESRKSRLRFFARPGSVNSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W440</accession>
    <name>A0ABM1W440_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Neurogenic mastermind-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106013863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mastermind family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829433.1">
        <property type="nucleotide sequence ID" value="XM_035973540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013863"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046369">
        <property type="entry name" value="MAML1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046370">
        <property type="entry name" value="MAML_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019082">
        <property type="entry name" value="Mastermind-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15692">
        <property type="entry name" value="MASTERMIND-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15692:SF20">
        <property type="entry name" value="NEUROGENIC MASTERMIND-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09596">
        <property type="entry name" value="MamL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01275">
        <property type="entry name" value="MamL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Neurogenic mastermind-like N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035829433.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18115" checksum="46B8CEA774A691E2" modified="2025-10-08" version="1">MGDFFAPKRKDVVDKIRRRIDVYRHHHSSSAGRYHGARPGIYEQQKQDTLQLRQRWLDSRAKKAAKQSKTSRDNNNIQNDHRNLVVTKLKKKIDSVSTDASTSSATTATTTAGAETVFNFEEQDQAGFNNLNNHSGSGGANNKNANSGAANNNNNSNLNGGGGGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>J7H575</accession>
    <name>J7H575_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C-Jun</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101863323</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">c-jun</name>
        <name evidence="10" type="synonym">c-Jun</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-06" db="EMBL/GenBank/DDBJ databases">
            <title>bZIP factors regulate basal synaptic strength.</title>
            <authorList>
                <person name="Hu J.-Y."/>
                <person name="Levine A."/>
                <person name="Sung Y.-J."/>
                <person name="Chen Y."/>
                <person name="Schacher S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Jun subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JX228175">
        <property type="protein sequence ID" value="AFP89967.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001268726.1">
        <property type="nucleotide sequence ID" value="NM_001281797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="J7H575"/>
    <dbReference type="SMR" id="J7H575"/>
    <dbReference type="GeneID" id="101863323"/>
    <dbReference type="CTD" id="101863323"/>
    <dbReference type="OrthoDB" id="2187714at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14696">
        <property type="entry name" value="bZIP_Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000012">
        <property type="entry name" value="Putative transcription factor AP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005643">
        <property type="entry name" value="JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03957">
        <property type="entry name" value="Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="223"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="241"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFP89967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="NP_001268726.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="32931" checksum="BFC01651D0D5933D" modified="2012-10-31" version="1">MEPSLYSDADGPDSEVKKLKRSMTLDFNSSSSTKQKKLAAVLASPDLNMLKLASPELEKMIIQANGMVTTTPTPTQFIFPKFVTEEQEAYARGFVDALAKLQNNSTRVLNPNRPQDLDRTFTTLTVPSALSQSATVPSSAVAVPLTSEVATTTTLPGGPASRVPARSTVSPPKTVLPTSVSNIPTTADSSDVRLPQIKDEPQTVPCLSSSPPLSPINMESQEKIKLERKRARNRVAARKCRTRKLERIARLEDRVKELKGQNSDLVTTATNLRDQVMKLKQQIVEHVNSGCQIMMAQNISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAJ2</accession>
    <name>A0ABM0JAJ2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A</fullName>
            <ecNumber evidence="8">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101849171</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55392"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005089200.1">
        <property type="nucleotide sequence ID" value="XM_005089143.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849171"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="10">
        <location>
            <begin position="62"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005089200.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38148" checksum="B7A3492B3003A74E" modified="2025-10-08" version="1">MSFNRMKEKVEYGDTVLVHVGFDNMLPFIVQKGVTHQTKFGAVRHDKLIGKKYGTKFQCPRGWVYIMHPTPELWTLSLPHRTQILYTTDISMVIFQLDLKPGSVVVEAGTGSGSLSHAILRTIQPSGHLHTFEFHEERSMKAREEFEDHGLSQFVTVTHRDVCGDGFQLEGVADAVFLDLPRPWECVGSAKKAMKTEGGRICTFSPCIEQVQRSCEELSKHGFSEISTMECLLRNYNIQFAKLQNMNFGDDDAEDSKTSVKDAEDPSATSPVKGDGDSGKNGSDDCTPAKVAKQEPEVTTPKSSNPKSKTTAGSSEVSSYCFTSAVPALPMQGHTGFLTFASLLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAM4</accession>
    <name>A0ABM0JAM4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein SSUH2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089285.1">
        <property type="nucleotide sequence ID" value="XM_005089228.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849172"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089285.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="53569" checksum="0BE0191FBFB2D25E" modified="2025-10-08" version="1">MTSYPGQGVPSYSGQPPPQAGYPPQGGAPGYPPQGGAPGYPPQGGAPGYPSQGGAPGYPPQGGAPGYPPQGAPGYPSQGGAPGYPSQGAPGYPPQGGAPGYPPQGGAPGYPPQGGAPAGAVPAYKGEVPSQDVRDDPNMAAPQASAPSLDMMDHLPGYDNIGFDGVSLPPPSYEESQREAPQRDNIESVPTISEEEARDALIQFVSEHCCYGKGPAEEMKFNDLNSSSAFHYTLETFGEGRSTKWAREPYKGQPVVVNGPPPGPWDIQAPPPAMFKTTKLDIEVPNTASVKPCHACFASGFQRCYRCHGRGRLFCTSCNGTGREHYYEQGERLHRQCVWCNGFGRKTCYTCSGSGQITCSECKGRANLRWFILLTIKWTNHVEDHIVERTALPDELIRGVSGQMAFEETQPRVWPINHFPEQEINSASNNLVHQHSSKFPSERMLMQRHRVRIVPVTQVFYKYKDDQDSFFVYGFEHKVHAPDYPAQCCCGCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAM9</accession>
    <name>A0ABM0JAM9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101850449</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005089290.1">
        <property type="nucleotide sequence ID" value="XM_005089233.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850449"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08223">
        <property type="entry name" value="STKc_Nek4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF7">
        <property type="entry name" value="NIMA-RELATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005089290.1"/>
        </source>
    </evidence>
    <sequence length="784" mass="87880" checksum="68D6ECEB0278B155" modified="2025-10-08" version="1">MGNEDFDRLRVIGKGSYGEVWLAKHKKDKKQYVLKKMNLGKASRRERKSAEQEAKLLSKLKHPNIVSYKDSFETDSGFLYIAMQYCEGGDLYAKLKEQRGQALEERQVVEWFVQIAMALQYMHERNILHRDLKTQNIFLTKSKIIKVGDLGIARVLDNASDMATTLIGTPYYMSPELFSNKPYNHKSDVWALGCCVYEMTTLKHAFNAKDMNSLVYKILKGRMPPMPGKYSSELLVLMRSMMHQEPEKRPSVNRILRDPYIKKNIAIFLEDTKKSSRRPSSASQVSIPAPSRPSSAGSSRKNSLPSSGAASGGGDKSSRSSQSESSSRSKAKDEPDSPRDNSAPADLAAKPPPARKSQEAAAPRDLEPIREKGEEPLKSSSSEAGDTQDTVVPQTVKEAKSPKKEGAPRKKNFLRNHMRNKSDEGEKAAEGDKNGGGDNISKPPSGGEKRNSKPVAVVEPQKPRLVKKEDKSRPVPMPRAEESSGLPQRRDDILPADGSRRPVSTDSSKSSSVSSSKEDNGGLDGETPRSLPNLSARQRRRQQKSDTAASYENPNTARIRLRRTPERSGSEKVTRAEKALPPKLMRPQRPRHARQPSLNDSTSSSDESQKVCEVEKDNSQEKELKRENKEMNNFISLLDTTLHMNNVRGNSDDEKEEEEEEEEEEELVPVEEEPVNSRASTPPTPPSQKHPHPDPAQMHKSVSMPSVETLTNTSRLMDRIRLLHKDCIQGVGYASLKKAYEILDKIDEDEVEPKLVELLGMEKFDEYAGKIWQLKFCEEALFMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCH5</accession>
    <name>A0ABM0JCH5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prespore protein Dp87-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090533.1">
        <property type="nucleotide sequence ID" value="XM_005090476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863156"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAP" evidence="1">
        <location>
            <begin position="367"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090533.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47670" checksum="7150F8BB517EF189" modified="2025-10-08" version="1">MAQECRVVEHCQKADVCSVGARCIWQGTIDYELDDVCRHNGYLEALLISISKEVDNFREWKCKGPDKFWECPPGSACVDDGKGGGTCCMGRPDYGKPGLCPVECRVVPSSGSSHESPEGCLKLRHFCGYKSYSECNTDVHCGKGQKCQIQTACSYVPPPPSDAPGDVLLRRRKRDMSSDLDSPMCQVCVEHNPGGDCEPFYKCVEPGVAKTCAAVRCGARSSCQMTGTPPRPVCSPRCTKKCRSGFKCQIYKGSQRCTDRRPKTCDGLQCPHKTQCKMIKDTCGPGSRCDKWRRRAKKAECVPVCSRTCKGTRQCKVVSKCPYGGGECEHNERCVQVRKPGTCPKCRPGRECALRRRCRKCKLRHVCVLSQGRCPRLPKRLRHPKSRACRRETRRQPTCADDSDCRQSQKCCSSKCGRQICRYAKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCJ8</accession>
    <name>A0ABM0JCJ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane protein 41A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101853755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM41 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090571.1">
        <property type="nucleotide sequence ID" value="XM_005090514.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853755"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="9">
        <location>
            <begin position="203"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005090571.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40913" checksum="5035FB51FD316D05" modified="2025-10-08" version="1">MDEDSLQVKRPKFNSAFRLCYSLQLVPCHNEKHQLIAVYPRRDSNNNNSSSTTNITWDSRCRCWRSNSSNSSSSSSWQQISPYWERLLQRVMENNNTDRGVRRSPSSQGGTPAPGSGHSPNSHLCWSIMWVPVIFSLATVSLYLLSHWFVDLEAGKSFALKFPTSIEDITQMSSFLLHMKETHLAYLLLVFCAGFIYKQTFAIPGSVFLNLLAGALFGPYLGFLLASPLTALGATNCYLLSRTFGRSYVTQYFPERVKFFQEKVEENKDSLFFFLLFLRLFPMSPNWFMNVVAPLVGIPIHLFFLSVLIGLMPYNFICVQTGSVLSEISSVSDVFSTGTMLKMSLAALAALLPGLVIKKLHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCV7</accession>
    <name>A0ABM0JCV7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoxygenase homology domain-containing protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090789.1">
        <property type="nucleotide sequence ID" value="XM_005090732.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862626"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01756">
        <property type="entry name" value="PLAT_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF3">
        <property type="entry name" value="LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="176"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="304"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="450"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005090789.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="75144" checksum="5C91A971AAAD27F3" modified="2025-10-08" version="1">MDDLNVWAKPPRPVLSGLNGRPRTSNVRYTWTGPIDPQLYGDGLKQLTRNTDRNLSRLEKEKKEILPSKQRHLGGPAQPPFVASSWHDSTVMFAPWGTLSTTSRKSSLADDASTVSSISGATNFCYLCSTLEEHQMHLMRTRIPKKVVVKKPRIVYRAPVPKVKPKIEEPKEILDWRYKVVVWTGDVPGATTDANVYISLKGDLNFLYKARLCRGNHTQKFCFCRGSRETFFIKSPRLGNLEILSIEHDGLEKRHSWYCEKVEITCMKTHRQWVFTCKNWLSLHHGDYSIRRDLLANQVERTSNEYELTVVTGTKRMAGTDANVFVTFHGTDGFSPKIKLTADGQRQVKNLFEKGSQDKFHLAFKDIGEIRTVRVEHDGKGLAAGWFLDRMILQNIKQPSIIYYFLLNGWLAKDVGDGHLWREIRAKKKLAKEITTAKGRRVVVIQGKPVSYQVTVRTGDVRYAGTDANVYIIIHGKKGKTKKLFMDDTRDNFERGQTEVFEVTALDTGEITRIQIGHDNSGPGAGWFCEDIKIKKFLNRENVVEFLKNLKKKKKPKKKHKKRLSDKLKERALADIPEDVTEDEESESEDDDKEGSYRNVFDREGKVVKVPVYEEYFFVCKNWLATDEADGLIERELEVKKQSTFFQDRDWQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JET3</accession>
    <name>A0ABM0JET3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0183 protein C16orf70 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092092.2">
        <property type="nucleotide sequence ID" value="XM_005092035.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855773"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092092.2"/>
        </source>
    </evidence>
    <sequence length="426" mass="48314" checksum="C8711A1DA199D754" modified="2025-10-08" version="1">MLDLEVVPERSLGNEQWEFVLGMPFYQAVNILRRQDSCIKGVQVWYSDQNPLQMDLVLNLSQDGVKLIFDPTYQRLKIIEVNSMSKVKLKYCGVPFNTPQVRPTIEQIDQSFGATHPGVYIADKKLFVLNFRGLSFDFSINSKYEPKYAHGLGSLQFPNGMSPVVARMCIYAGNSLTDARAPALPVACFYGNCFLDCLEVLRDNNVTSGLKFLLVTEGNVQGKLVDPRKKSVERIVRFGDSVQDVVSALGCPSRMFYKSEDKMKIHLPDAHRHIRARSADYFFNYFTMGVDFLFDAVTHTVKKFVLHTNYPGDYNFNIYCRCEFKLPITVEPSRLSQSQTLMLEDDLLVITAYSKWDEVQKVLMTPKHRPVILNRSASTNTSNPFGSTFCYGVQDLIFEVMRNQHIASVTLYQSPSSRDPAAVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFC7</accession>
    <name>A0ABM0JFC7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TELO2-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092413.1">
        <property type="nucleotide sequence ID" value="XM_005092356.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849277"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092413.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55510" checksum="031B7A05B69B94F5" modified="2025-10-08" version="1">MAGHSNESEPTSTMEPLVLPHVADKALSDITALLREASSTSCNEKKVKVLLKASGLIQELHERFTSIDADCVGFTLALQHVLRSCVVSTFSNRDYFSYSYEDFEGISFVSEAVLQVLVAVLVAAVKEKRAGENVPQLVELFCDEIVLDLLIIIGANIEDSLWSSVKASELSNEVLNNVLKLFSCETVNELLCMEVKTANHQNVKKVTLFSLFLSHSKDFLSKEQWQRNPYMCKVFCWFLSQAKFPLLSDHIDLILAVSLNFLLDHQELNKVQGLKVIHHLVLNVTSEEIRWYNRIEVVHQALNQQLHSKECLVLSELLPTLFASVCVLDKNTTSADYHCGLLETLLRNADMENLLVLRRLYMSNIKILIQQMGFPSAGKLGLILGVISNYLQIDDGSSDICRVKTLEVLQTIVEVAWPRIPPHRDTILKCLLKVLVDIQTLHYQETHSKEAQMQMKEKINGICQMLCKVCPSATKCFEALKDSNHVSHLLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFM5</accession>
    <name>A0ABM0JFM5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="9">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101845606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="9">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005092571.1">
        <property type="nucleotide sequence ID" value="XM_005092514.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845606"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="12">
        <location>
            <begin position="135"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="13">
        <location>
            <begin position="256"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005092571.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="43829" checksum="9A9EAF57307FC4CA" modified="2025-10-08" version="1">MDSNTNFPGEFPSQEETFLFTSESVGEGHPDKICDQVSDAVLDSLLRVDPYARVSCQCAAKTGMIFVCGDIASKASIDIQKVVRSTIKNIGYDGSTKGFDYKTCNVLLAIEEPHSNSFSSHYYQEPDGSSAENDPAGDQGLMFGYATDETEECMPLTIQLSHQLNARMAQLRKSGELAWARPDSKTQVTVEYKIDRGATVPMRVHTVVISVQHEEHVTMEQLRSDLMEKVIKPIIPSKYLDSKTVYHLQPSGRFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGALSGKDGAKIDRCGSYAARWVAKSLVKAGLCRRALVQISYSMGVAEPLSITVFSFGTSSKSEEELLAIIKKNFDLRPGKIVNELDLRKPIFQQTASYGHFGRPEFSWEVPKRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHZ0</accession>
    <name>A0ABM0JHZ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Arginine-glutamic acid dipeptide repeats protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101864371</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005094052.2">
        <property type="nucleotide sequence ID" value="XM_005093995.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864371"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002951">
        <property type="entry name" value="Atrophin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859">
        <property type="entry name" value="ATROPHIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859:SF11">
        <property type="entry name" value="GRUNGE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03154">
        <property type="entry name" value="Atrophin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="16">
        <location>
            <begin position="181"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="17">
        <location>
            <begin position="319"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="18">
        <location>
            <begin position="428"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="15">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="15"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="480"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="568"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="815"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1029"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1517"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1662"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="757"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="839"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="896"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1044"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1112"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1127"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1140"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1151"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1208"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1259"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1276"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1341"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1376"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1401"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1415"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1446"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1484"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1548"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1563"/>
            <end position="1585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005094052.2"/>
        </source>
    </evidence>
    <sequence length="2004" mass="212582" checksum="7BFA0030B545A409" modified="2025-10-08" version="1">MNSAANTITTNNAVASSAVSGSSSNSPITTTTTSNNSTTNGGTISIHNHNINHHNNNNNNDDDNGNASSDMNEVDFDKADTPTNAHHRTHNNSASRGDPEQSGGSYSPKSEKSGKSSAKKKATSKSSLKMAVDKKKLEKFVGEGEQLLPVPRARRRLKGSDLGYMVKRGESVVRYIDKDGIVYNPNDTAYLQNREKGKPYFVCAIQRFNLTKRDTLMVGVKWFFRLSEVPGSVYHHLTLDRELHRKNGEDIICDSSIQQRELFSSEATDTLPITSLRGKCEVVQYSDLRAACSFVPSPDHFFYILAYRPDNRRLATTQGEIRVGPSHQARLPECKPGTSPAEMPERCESREEIRWRPNRVVDGDLLMYLRAARSIAAFAGMCGGSAEDRCEAEAMDETTVNALDTLHKHNYDTSKSLQALVKGPSVMYIEKKWNEEDIKRFAKGLRHLGKNFFKIRKEHLPHKDTSELVEFYYFWKKSPAATNSRPTHRSRHRRQLKRQSPRNQPDNEVSSGSDSAEESEESDGGRDVVSICQRCCTTNSKDWHNAKEGGVVCTKCRLFYKKYGDDSAIESPPATSSPSPFLFEDGESTPSKHNMRTRRSNNTASTNGKKKDRTSVSSPDTEAAASLGPNASTSSNTITANNSSSSKGGRKSPPTGDKENKKSSQKSKESNSAKAKKRRIPAEEDSKLAKKKKDRSDSESGTDSSSVSGAEDAANDADSDDNNQEELSSSSRPSSPSSVERGFKPLQPQPPTPGSHPLLTSTSSGVTSGPVTGNKPVSSLELTPSSVTAAQGTLVAASSVSHATGGSTFVSPLAASAHPAVTSSAIKTVPGPPVPPSLVPAGLPQGSQQQQQSSQLSQSSPFNNSLPSSLPPLTSQSSATLAASSLIHLPLPPHHPASLTSSSSATHLRRQQQPQGLGGPLSSSQQQHPLTVYKSGVVGPLPGHISAIGTISGGHHGNSSGPGSLIVPPPTSCNLSSPLVIPTPSLSRASSTGTFIPHPAEVPVPPPPSSVCVSASASLTSVTTASTKTISALTSGEPVIPSPSVLSNRGGSGSSLTSSSSSSHLGLAISSSNSTLSGTLGNSSSSGSSSGGSTPFGRMQDPGEEPQDKKPIVPPPSAYLPPPPGSVPFSPYHSYYYPHPGAPHLPPHPSLHPSVAMSAASSSSSSTSSSNPHPAPPPVPSLVPIKKEPHSPPPPLKPSDKTASDIISSSSSSSGSSSSASPHPLHRPHPENPGKIPHGFPQSGLPSTAPLPPPPLTLIDHRDSNSSSKPDDLSKADSYSSSKDSNPPRGLPPSPHRSSENHPSVLQHRESRMDSNLSVLRESREIGLVGGLPGPPPPPSSSSSQQGAHSAPPPTLKDDPRVLSAAFQPYSHHPHPSSSSSSSSSSSSSHPPPPSHPISSVLQIPQRQLQSDPSAPHPTGPPLHPSQGGPLMPGDAAALMSSHAGGPPPSRPLPPPGADVDSLVKKEPITVEDDTGSDDDMRGGSTTPGPTSACSKEIYKSNSAIFIKVFDRGERNQCSRTDFVFKPLPESNLAKKRRASHSSSTSSIKEEKKRVETPPRATSVSEGQKSSSSSSGSSSNLPSSSGGAGPPHNISSSAYAERHTPRPFADTPALRQLHEYARPHVLGQDIPRGPYTLAGLPHHPQMDPLMSYRLGMYPPGSRERLEMELERDKRERDARERDMRERELRELELREKMKADFELKPGMMKPGLERLLPPGAATQLTDPSWLDIQRRMGFPPTAGGPLVPGGPSVSAAGSHLPGVYPPVSLASDLVAREREKLERYGLAASFPQLAADMSYASAVERLSAERQAAERHAAERERDRDRLAALANDPVARLQLAGAAAAATQHAHTHTHAHSHTHLHLHQQEVAHAQAVAHAQAHGLAPPAFPHPLAAHAQHLYPHHPLAAGGPGADPLAAGPGASVPVSSTNPLSVLPPGVAHHPLLAAGGGREELLSRDLYQRGGPFLDPALAHQLSAQAAAHEALQRHFAMERERFGSAGHLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI29</accession>
    <name>A0ABM0JI29_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine incorporator 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101861194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094122.1">
        <property type="nucleotide sequence ID" value="XM_005094065.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861194"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005094122.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="54622" checksum="57918F238C6BA3AC" modified="2025-10-08" version="1">MGCIIGTGLAGAACCCGSAACSLCCAACPSCKNSTASRIGYSLMLLFGSIVAVIMLIPGIRSKLDDIPGLCSGIFDGKAPPGMDVSVFQKEQCDHAVGFLAVYRVCFAMAMFFLLFCVLMIKVNSSKDPRSKIQNGFWFFKVLIMIGICIGAFFIPGGTFGEVWMVVGMIGAFLFILIQLILLVDFAHGWAESWVELYEETEAKCYYIGLFFFTILFYLISIVAIVLFYVYYASGDCALHKFFVSFNLILIVGMSVVAILPRIQEHQPRSGLLQSSIISAYVIYLTWSAMSNNPDTKCNPNLKDIIDPPTHNITTAATVGGDANGTGTSDGVFDWQSILALAIWLFAVLYSSIRTSSNSQVGKLTLSEKTILQTDTDTYKSKRKSGSSEDLMVFTVSKGSGIPLPGSSDSEGDAETGQKVWDNEEEAVAYSYSFYHFMLFLAALYVMMTLTNWFKPSSDMTTLNANMASVWVKIVSSWLSILLYVWTLVAPAILSGRDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIH8</accession>
    <name>A0ABM0JIH8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein pellino</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101863733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pellino family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094406.1">
        <property type="nucleotide sequence ID" value="XM_005094349.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863733"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048335">
        <property type="entry name" value="Pellino_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF2">
        <property type="entry name" value="PROTEIN PELLINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20723">
        <property type="entry name" value="Pellino_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038886">
        <property type="entry name" value="Pellino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pellino FHA" evidence="4">
        <location>
            <begin position="11"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino RING" evidence="5">
        <location>
            <begin position="275"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005094406.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="45929" checksum="44284B868DBBF761" modified="2025-10-08" version="1">MSADSSIQSAESAENIKYGELVVLGYNGHLVAGDKGRRRSKYILWKRAKANGVKPSQKHLVTNPQSSKAVQDQSKHSVSYTLSRNKAIIVEYLRDEDTDMFQVGRSMEGPIDFVVMDTVPGHLRNQRDSAPQSTISRFACRIIVDRSPPYTARIYAAGFDSGRNIFLGEKAVKWCSDDNVDGLTTNGVFLMQPQGGFSPAGKPGPWREVSVGGGLFSLRDSRPSPLKSHQMTEEDNILRDGTLIDLCGATIVWRSALGLIASPSENEFQQLVGRLNAGRPQCPVGLNTLVLPTRGSLNLRDRQPYVYLPCGHVHGNHEWGQAAPDANIRKCPLCLTDGAFIKLQMGCELSLYVDSEQPTYCLAPCGHMVSECTAKFWSRIAVPHGSHGFQTICPFCATPLSESTPYVKLIFQDNTDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ31</accession>
    <name>A0ABM0JJ31_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">17-beta-hydroxysteroid dehydrogenase type 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094807.1">
        <property type="nucleotide sequence ID" value="XM_005094750.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855631"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094807.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40225" checksum="AD0C24ED82921B3A" modified="2025-10-08" version="1">MDLFSTILGAALLLCGVIATGLLVLKYKSRKKMLLPTFKSVLVTGCDRGFGFMLAKRLDEEGFKVFAGCLDATGEGAKELQMDTSPKLELIQLDVTKEKEIEEAKAKIIDSLAGYMLWAVVNNAGVACHAEFEWIPKRSFQHTIDVNILAVVNVTRAFLPLVRAAKGRIVNMASMAGRTATPGFTAYSASKFAVIGFSESLRREMAHFGVKVITVEPAIYKYVQLSVRDFQIDYSVTALSSTTNFLGQCEEFWAQAEPGIKRDYGEPYFLATQEAKSRLLQWTSPALDEVVDCYMHAVASVQPHSRYVPPWKLQLLNDVMNMLWNSVQDRILAAVMNIRAKPDMLRPIQNGRTGRRRSHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ56</accession>
    <name>A0ABM0JJ56_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-protein phosphatase non-receptor type 9 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101863971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094847.1">
        <property type="nucleotide sequence ID" value="XM_005094790.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863971"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF534">
        <property type="entry name" value="LD27988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="4">
        <location>
            <begin position="81"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="411"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="588"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005094847.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="79978" checksum="BD92790B52392E7B" modified="2025-10-08" version="1">MDFFSGPWSKKNNNLAIQDFLSEVNLSQGQRHRSPVSWGTGCKFLMARKFDVKRAIDLFFSHESTREKEDLLSIDPSDRYLQKELSTEKFTILPGRDRSGAAVALFSARLHQPPQTTHQVVLKSLIYQLDAALESIETQRQGLVFIYDMTESKYANFDYDLSIKILNLLKGAYPARLKRVLIVTAPLWFKAPFKILRLFVKEKLRDRVYTVSVSELITYVPKDTLPIQLGGTQVPCHQVWLQLCFQCATNQQPDPCIYFISRLSGPGANRGSISRSISTDTDNHISDFDSESSKDTVNEKHTNEDREKEKEDDMEEESGKPDSTTVVSKEREGQKVGNRKRKTSESRKHSSDLSTVNEAPPETLSEEMPRKKRPPSSGSNILDDSIHMPDTNGMTVQELLNKVNSLKRKGLVGEYGSIKMEAPTGTFTTSKLKANLPKNRYTDVLCYDHSRVTLPLIDDDPTSDYINANFVDGYMQKNAFISTQGPLPKTFVDFWRMVWHNQTKVIVMTTKTIERSRMKCGQYWPNEEEADEQFEEFIVYNNGMSQNKDFIETVLMLHNTNSGESRQISHLQFISWPDYGVPPAAPFLDFLFRVRSIQEKATKDMASDWTGHPLGPPIIVHCSAGIGRTGTFITVDICLRRLEDVGTVDVRETVRRIRSQRAFSIQMPDQYVFCHQAVIEQAQRQGLMNSIEQIVLEDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ63</accession>
    <name>A0ABM0JJ63_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-like domain-containing CTD phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101846063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005094856.1">
        <property type="nucleotide sequence ID" value="XM_005094799.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846063"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01813">
        <property type="entry name" value="Ubl_UBLCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="4">
        <location>
            <begin position="136"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005094856.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38592" checksum="A4531F94EC402EB2" modified="2025-10-08" version="1">MAGEVGDLIVKYSRDEHKISGLLGSDTVKDLKDAIYKLTSVQPNRQKLLGLKVKPSDLVDDMMLSALKLRPNMKLILMGTKEEQIEKVSETPTDLPEVVNDFDIEEEEIAVENREEYLAKIDRRIKSYKINTLNESRPGKKLLVLDIDYTLFDHRSTAEQANELMRPFLHEFLTDAYKNYDIVIWSATGMKWIETKLKLLGVATHPDYKICFYLDSDAMISVHTPKYGVIEVKPLGVIWGKYPEWSEKNTIMLDDIRRNFIMNPQSGLRIKAFRDSRVSRFTDTELIKMTEYLNCIALLEDFTALDHRNWREYRKKSRDKESRTSDRPSTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKE0</accession>
    <name>A0ABM0JKE0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein VAPYRIN isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101862259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095775.1">
        <property type="nucleotide sequence ID" value="XM_005095718.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862259"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF17">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 10-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005095775.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="43002" checksum="49F199D5C4D784D6" modified="2025-10-08" version="1">MDMNFEKKPPGLLDVISQKLLSQTPLHFACYNGDEQLLETLIGRAFLYNNNDGEAAEACVSSWVSEEDGINGWTPAHWAAFYGQLKCLMKLHVKPNLGFDTATHRSNTSPLHLAAQTGAVLCLKWLLQCGASKNRQDFMGETALHKASKAGNADSAAMLIAHGCSLNLKNHRGMTPVELAEESGYHALAQYLRRAYEQSEYGGTTITREPHSLPLSELNPPTVCTNQTGVQFAPSDSDRLHPYISMNGEVINNSGSRAAPQDSMDLGDSEMQDSDRPSIPEFFLHGDNKASGFGGTKRSFDSEDDDLNSNKRRCFVAASQQTHEERYGNSSNNNIISSYNAVLAMRVEPLTTYTGEAPGSPVLPQSSVMDHQASLVAQQGYDSSFMNSIGSAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLA9</accession>
    <name>A0ABM0JLA9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM177A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096380.1">
        <property type="nucleotide sequence ID" value="XM_005096323.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864380"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028260">
        <property type="entry name" value="FAM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206">
        <property type="entry name" value="LP10445P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206:SF1">
        <property type="entry name" value="LP10445P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14774">
        <property type="entry name" value="FAM177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096380.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19731" checksum="F37CFFDE0C06AF15" modified="2025-10-08" version="1">MADSAIHGSFGTETFTSVPLDAEAAVGADKKKKKPKRILHFSDGILEEYSSSSEDEDAKKDVGPLVDPKTLKWAPWCFYYASTAARKALGVADVCGEKLAWFFGITTPKYRYEIEEYKRAQKELEEDMEQERRQEEKAQGLSTIDVQVVDSCKTSTTTIASNNNSMTEPPELLEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMD0</accession>
    <name>A0ABM0JMD0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NXPE family member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097066.1">
        <property type="nucleotide sequence ID" value="XM_005097009.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847419"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NXPE C-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005097066.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22721" checksum="714B554775688F17" modified="2025-10-08" version="1">MKRMFNIMQTDFCTTTAAEDRPFPSPANCSNPELNITIYFAAHAHPFNLPHPDHFRVFNKPLSHWLDGIRAEADVVVILHLYLHFSQFNLEVFNLHAQDAQRGVARLLRRNPRARVVLRGPHVTYKGWPSHVAGGDLLAEHFHQILRREFTDVRHRVCYLNAWDMTVAVANLNFHPEEFVHRAMLQVVFAHFIGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMN9</accession>
    <name>A0ABM0JMN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101856802</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097280.1">
        <property type="nucleotide sequence ID" value="XM_005097223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856802"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097280.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19885" checksum="D9849FBB626E0441" modified="2025-10-08" version="1">MDNASYHNVVEEEDNIPTSASRKEEMTDWLNQERIPFAPSQLKPELLLLVEERRKAKRFQVDQIVEQHGHICLRWPPYHTHLNTIELVWAKIKGTVASQKTNFKLKDVKQLSENVISRVDKVYWRQWETHGKRMKDEYWEKEGLEFIQPRVVINPCEDSSDSLTEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMU1</accession>
    <name>A0ABM0JMU1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neural Wiskott-Aldrich syndrome protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005097379.1">
        <property type="nucleotide sequence ID" value="XM_005097322.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860566"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21762">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF36">
        <property type="entry name" value="ACTIN NUCLEATION-PROMOTING FACTOR WASL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WH1" evidence="7">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="6">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="8">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="8">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005097379.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="57796" checksum="7A75F891BD1BC5EC" modified="2025-10-08" version="1">MSQNRQKAVNAPSILLQDHENEALFQTVGRSCTTIATGVVQLYLADPPDRTRWSKRCCGVACFVKDATKRSFYIRVYDIKKQQMIWEQELYNQFVYKTPREYFHTFEAENCQAGMNFASEDEAMKFKKAVDQKLHERRLKRQERKRQTMAQKHGGGGTNASGAVPQRMGQSQAPPQQTITVDLNRNNNTSNNLKKDKDKNKKDGGKKKLTKADIGTPSNFIHVSHVGWDPDKGFDMDNLDPDMHKLFQSVGIKPDDKVDKDTIHFIYEFVEQHGGIEAVKKALGPNEGGGAPPPPPPSNRGVMSMPPPPPARSSGPPPPPSRAAMPPPPPPSRGAPPPMRGAAPPPPPSRAPGAPHRAPSSAPPAPPMSAAPPPPPPMAMGSRPPPPPSSGPPPPPPPAGGPPPPPPPPAGGPPPPPPPPPPPPPPTASPAGADTSGRGALMEAIRGGASLKTSSHTSNEAPKSADSRGQLLDAIRHGAQLKKVDNQEDRPVSSGPEEMGGLVGALAKALASRRPACVDSDDDDDDDDDDDDVSDDDDWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNN4</accession>
    <name>A0ABM0JNN4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101864689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005097931.2">
        <property type="nucleotide sequence ID" value="XM_005097874.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864689"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="9">
        <location>
            <begin position="75"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005097931.2"/>
        </source>
    </evidence>
    <sequence length="371" mass="42664" checksum="60F4C835AB60D532" modified="2025-10-08" version="1">MRNLQVGLLNRLKVIPILPCSKWTLRFKGSVSKPEKSKRYANTLNLPQTLFPLSMKHGAAAQRELEIQKTKEFQNLYYWQRQQNWTEEFVLHDGPPYANGKTHVGHTVNKVLKDITNRYKVMKKCKVHYVPGWDCHGMPIEVKAITDDMGQHQKLSPLEIRAKAKKFAEGVIREQRKSFMRWGIMADWSKSYLTMNPQYQEKQLEVFYKIYQKGFVYRNYMPVFWSPSSGTALAEAELEYNPEHVSKSVYLTFPLLTQPKVEQLDKVSGATVHAVIWTTTPWTLPFNQAICYNPGIRYAFLKCAKSSNVYLCEESFVEKLKAIVGGDLELLCNVDGHTLEGTVYKHPLNQQELPFLPGEHVLPGKGTGLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQB0</accession>
    <name>A0ABM0JQB0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101863024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099027.1">
        <property type="nucleotide sequence ID" value="XM_005098970.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863024"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005099027.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39050" checksum="B7A6A69FE4055233" modified="2025-10-08" version="1">MPGGDGDKANDLKERISAFVDEIKKSNTNGSCDVAIKTINLLIRIISQAKFSNARELLVHVRVEGMHIQAADPSENIIGNIIRRVLKIIREEYRELLLQKNEDQVSAMERLSMADVDEGDYSTPFPQLKARVIEAVSELKIELEGCVENIAALAPNYVNENDVILTIGRSKTVEAFLKSAAHKHIKFRVYVSEGAPFYGGHEMAKNLAQAKINTTLITECQIGTIMPLVNKVIVGTHSIMANGGLKAVTGTNIMAVLAKEHNKHVIVCSSLYKLSPLFHSTPQHASFNKFSSPNELLDYEDAELLSKVEVIAPIFDYVPPDLVSMVVTNNGAQSVTYVYRLVKDFYHADDVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQG8</accession>
    <name>A0ABM0JQG8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101851868 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101851868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099151.1">
        <property type="nucleotide sequence ID" value="XM_005099094.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851868"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005099151.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12496" checksum="6F3B9095F2D3C7A8" modified="2025-10-08" version="1">MTKSKKQGPVVAMQADESASETWRKEAQSFVEVELASVKPNGTKVIHNTSFGLDILIGGLKKDVEKYVEGVGKTQIWSHNSMILKDDSTLTDYVDDSHIEGKRPFKVKVFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRF5</accession>
    <name>A0ABM0JRF5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemagglutinin/amebocyte aggregation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101846819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099798.1">
        <property type="nucleotide sequence ID" value="XM_005099741.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846819"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040:SF1">
        <property type="entry name" value="DERMATOPONTIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040">
        <property type="entry name" value="DERMATOPONTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047082008" evidence="5">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005099798.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21075" checksum="10CABD6560007414" modified="2025-10-08" version="1">MMLIFLILSVFGTHHLALAAYATSYDQAFSFTCDVGKYLQTIESIHSNYHEDRVFNFGCESLKDTHAEETMKDCVWGPYANDMDGILEFQCPGDKIISGLSSYHDNHYEDRRYKFYCCNPGNLVPYDCKFTSFINSYDNLLTYRVPDRSVIRGVNSVHDNSHEDRIFKFDICKLGALADEPTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRZ5</accession>
    <name>A0ABM0JRZ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Sphingomyelin synthase-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC101854579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100175.1">
        <property type="nucleotide sequence ID" value="XM_005100118.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938950.1">
        <property type="nucleotide sequence ID" value="XM_013083496.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826105.1">
        <property type="nucleotide sequence ID" value="XM_035970212.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854579"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09515">
        <property type="entry name" value="SAM_SGMS1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="11">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005100175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012938950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035826105.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="52455" checksum="0DE7EB24B5B7CC76" modified="2025-10-08" version="1">MEDKLENVDTWTCEDVEKWLKANGFIEYATKFSQGHRIDGQGLLSLTEKDLKDPPMSIPYLGDIKRLSFKIHALQAQNIKPSKLIAREAVHLLHESSCRERTQPVNPGYDRQGTPSRQDSTESEGFDNSLFQGTSVRSRHTFRNSTCSPSQDIPMELWKTVLSFLYIFVVFLITAFIMVVVHDRVPEMDRYPPLPDLFLDNMPYVPWAFEACEMVGLVLAIMWFALLFFHKHRFILMRRLFSLMGTIFLLRCVTMLITSLSVPGKHLQCSGRRYGDFYSRLERAIEIWQGFGMSLQGVRTCGDYMFSGHTSIITLLNFFITEYTPRKYYFVHIISWCLNFFGIFFLLAAHEHYSIDVFMAFYLSSRLFMYYHTLANNRALMQPDARRTRIWFPLFAFFESKCQGRVPNQFEWPLVYFAPCMKQIGFWIKCMFSKVGRKPEEKEAVKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSN7</accession>
    <name>A0ABM0JSN7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-splicing ligase RtcB homolog</fullName>
            <ecNumber evidence="8">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101849774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Catalytic component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005100586.1">
        <property type="nucleotide sequence ID" value="XM_005100529.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849774"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03144">
        <property type="entry name" value="RtcB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027513">
        <property type="entry name" value="RtcB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="225"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="352"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="401"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="427"/>
            <end position="430"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005100586.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="55662" checksum="F78A5141D56E097F" modified="2025-10-08" version="1">MRTYQDELKYLEKITTNCWHIKKGFVDNMKVDGYFFVNDHLEKLMFDELKQSCNNRGFGGFLPGMKQIANVAALPGIVGKSIGLPDVHSGYGFAIGNMAAFDMSNPKAVVSPGGVGFDINCGVRLLRTNLHRRDVEPVKEQLAQCLFDHIPVGVGSKGIIPMTAQNLEEALEMGMDWSLREGYAWAEDKEHCEEYGRMLQADPSKVSSRAKKRGLPQLGTLGAGNHYAEIQVVDEIYDEYAAKKMGIEFKDQVCVMIHCGSRGLGHQVATDALVAMEKAMKRDQIEVNDRQLACAHIQSAEGQDYLKGMASAANYAWVNRSSMTFLGRQAFAKMFNTTPDDLDMHVIYDVSHNIAKVEEHFIDGKQKTLLVHRKGSTRAFPPHHPLIPVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMVETFGTTCHGAGRALSRAKSRRNLDYTEVLEALEQKGISIRVASPKLVMEEAPESYKNVTDVVDTCHTAGISKKAIKLRPIAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSX0</accession>
    <name>A0ABM0JSX0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed primase/polymerase protein</fullName>
            <ecNumber evidence="6">2.7.7.102</ecNumber>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:22509"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.102"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.102" evidence="6"/>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005100740.2">
        <property type="nucleotide sequence ID" value="XM_005100683.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846888"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044917">
        <property type="entry name" value="PRIMPOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399">
        <property type="entry name" value="DNA-DIRECTED PRIMASE / POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399:SF0">
        <property type="entry name" value="DNA-DIRECTED PRIMASE_POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03121">
        <property type="entry name" value="Herpes_UL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="812"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005100740.2"/>
        </source>
    </evidence>
    <sequence length="961" mass="106704" checksum="42187A4C93F9D8B0" modified="2025-10-08" version="1">MKQQQTPTEMTSATSAESDHVIPVRKFYGSAHRKRRKCLDRPRGHERLDKRDVWRWKVPLDYHTRLLGPTFCWQTFYRQRDAFKFVEGCNEDVRVFAFERSGPETGPSTGQRQYLVTSTPVFWHYYRQLAPDQRHHYEIIPEGNPCKLYFDLEFMVDYNPRADGPRMVDVLIQYVSAWLYLTFGVSCGRDDVLDLDASTKSKFSRHLIFQLDQAVFQDNVQAGQFVRRIFGQLVQHVGHPEPVGNAEARSSCGVVRESVGASGSQRREGSARGDCGTSRSRSLTSPNLLGEADVCDSFCPDDSFDEEISLFEDDFFDESLFSFEVYPMEDGDDDMDAGGGAVRSGSKRAMNAESLQSSAQSRSDLEGGKTISVSPTRVSESADDFGSKENDNNNDGRFCSGGSDKSETHRVDFGSVNDNGGRLCSTGSEKSETHRADPGSRVNVYDSDNGRRFCSSGSEKSETHRVDDSGSRSETCVSEEKCGLGVVPVDLPDVSLPSLHTRSPGHHHQRASRSHKTAESTFSSIGADCTNTDHINAADDGEQVKGGDCCRTASPTDADVARLFEQFDGEDLRSLLIVNKDGVSTLFCDLAVYTRNRNFRLFLSSKGQKQNPLLVSRQNTFRPPEHVDVDEAVFYASLISLGRHTPGAKVLQFESSAPAELRNVPMSSSGLRVGPSSTRKVATESKQDTMEGWGCLSPFVETDHFILSLVSGAGRRGVIRHWTYFPGSDSLIYDIAGSRWCGNVGREHRSNNVMYVVDLRRAVYYQKCYDPDCQAVGYKSEEKDLPRHCLPWTFLSDDEFSDEEMIPDGQEEMTHVGRDNPTSSSMNHIGRDDPASSSMNHIGRDDPASSSMNHIGRDNPASSSSESCERQHPGKGVGEGEGDCESRRAPKCENQRGAQRTVGRSRLGEDTVISTVDRRFDELDEGVVGVGMEEDEDEDGVDFMLVTAAEKAEQEDRLCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSX1</accession>
    <name>A0ABM0JSX1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101847267</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR91 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100741.1">
        <property type="nucleotide sequence ID" value="XM_005100684.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847267"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056327">
        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039724">
        <property type="entry name" value="WDR91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="10">
        <location>
            <begin position="50"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="9">
        <location>
            <begin position="605"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="609"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005100741.1"/>
        </source>
    </evidence>
    <sequence length="789" mass="86782" checksum="593360ABC0E9CAA4" modified="2025-10-08" version="1">MASSCEKLDQLVKDYLLFRGFSATLKTLDQELKTDKDKGLRVDRMMEQIWTLLSGYDLPGLREYWRYLNQRLFSRLEQRYASSVRKLESSLLKLYVVNAHQCNRQDKVLAFFEQMGGELQTHADFKDWFAFPFVSNPAENPMYSLYFQKQWQDTLQLSLHNFLSVVLQAMPVPTLLNVEFDARRMKTLQEENSLLKQQLLNSAANTDALVRETRAGTRRNIHAELHPPSSPPDMVYDFSGLASDADTGSQEKQKPVRRFPLSLTSPLGGRRKSENAQTKSKSAASSGVSLSASASGGASTSGGQSKTAKVTEMSIFPPPAAARLQSESKKSQAVSMAASTAATSASSARQLNTARFGTSSPAPRRSSPVQPVKQQAHSTHESISTTTVTQSFTSRSLSVPNHSAASFSKLSSQAAPEMANKLLHQWSEEGKSLPPGSFSVETDLLVAADCDSPFLLLEDEYREHGSTASFCRFSVTGQYIASLDVDGIVKVWMWSPQPATQATIMSKSAFLSLSWVSKSDRWLLLGNKTGSIRLFDVKESKTFREVMVQPDAPANCMRVTDLSTNPSSSQFVCATSDHCPFLSDPSSLSGRLLQWDLRTLKLERALMVESSTTNAITCSCYSRDGQTLATGGADGWVRLYDANQQKAVKKWQAHEGPIHSVQFHASGSVYSMAADGKLSEWSMARPGQLLNSLKVGQRNLTLVSPGSTRGRLFALDVEGQHLLTYSGRRGAIYKGSGSSALQCIMELKNHMSPVITVDWSPSQDTRVCLTSSVDGKIKISTLLQNDGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JT92</accession>
    <name>A0ABM0JT92_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L14, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC101857032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100955.1">
        <property type="nucleotide sequence ID" value="XM_005100898.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939410.1">
        <property type="nucleotide sequence ID" value="XM_013083956.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857032"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005100955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012939410.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16255" checksum="1CF0EAA84D6D5C72" modified="2025-10-08" version="1">MATLLSNASQFAPAAVRLGTTCCAFSTTSKLLEVRLLSRMRIVDNSAIGRAAAEIGKPPRVIHVYNKKQVGHLGDKVLVTVKGEMRRAYIVGLKQKQRPNVPRTDTNNIVLVDDNGNPLGNRVLVPIPSALRANKKGDLTKVLSLATKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTP0</accession>
    <name>A0ABM0JTP0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Receptor-type tyrosine-protein phosphatase O</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101251.1">
        <property type="nucleotide sequence ID" value="XM_005101194.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847734"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF553">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 10D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047119340" evidence="1">
        <location>
            <begin position="17"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="227"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101251.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="41020" checksum="423502E50491D205" modified="2025-10-08" version="1">MLVIALILGAVFFVHRRRKQRGHKETRPVLPDTLEETETIKTRRPILIRTFRRTLLQLHRDSDLLFRAEFQDLQKLSARLPHGEKPVDELPYVNVDGKLHSDSETMDVFKANYIQGYNSVREYIAAQSPMPSTVPDFWRMVWEHKCKVIVMLSDHTKGVKGKEKSYWPKNLDESVEYGGVVVKTTNVSLFNKYTMRKFQISMGSDTRQLTHFSLQGWTDAKADLTVDDVVGFVQIVRQEATLTNSWPFVIHCSAGVGHTGTFITLDYFTQYVDKHSLDENMDVFSYVMKMRENCPGMVQMETQYIFIFDALMAVIQKKMTEEQEGLYERIEESEEGRNHIAPLEETPHYYSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUR1</accession>
    <name>A0ABM0JUR1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855502</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101967.1">
        <property type="nucleotide sequence ID" value="XM_005101910.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855502"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045316798" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101967.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20716" checksum="27CE487715D9EE93" modified="2025-10-08" version="1">MSRVTALAILLSVAAFAASNPAPQPCQFPSQFVTLETCMEYRRWANVFSDFTNKRKLLDFVDSDDFIYVDMDAQITKRKFGGVCLTYREKGYAINFDSIPASSVLETRAGSTVGEDVEVVVWKIDTPATEGEIAVTKDTCYPVYSSLVDKSTEKSLYLLYTDVQEEGFDASVFDNLDFSGCPDEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV98</accession>
    <name>A0ABM0JV98_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homologous-pairing protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101862123</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102347.1">
        <property type="nucleotide sequence ID" value="XM_005102290.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862123"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="9">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="10">
        <location>
            <begin position="151"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005102347.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24548" checksum="FD0CB1B4C06803E6" modified="2025-10-08" version="1">MSKSKEAVASQAVFSYLLKQNRPYSAQDLFQNMGKDLGKTAVVKALESLTAEGKIKEKVYGKQKVYVIDQTQFPDVDESEIKSMDDKISQLNGKFQLRSEEVRKLESELRAFNGMLSTESARAELSKLYSELEQLKVKLNKFKEGRVLISKEEKDRVYQNREKYVKEWRKRKRVTSDILNAILEGYPKTKKQLYDDIGIETDEDYNVKVPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVW3</accession>
    <name>A0ABM0JVW3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer dense fiber protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102734.2">
        <property type="nucleotide sequence ID" value="XM_005102677.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849626"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF28">
        <property type="entry name" value="BOREALIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102734.2"/>
        </source>
    </evidence>
    <sequence length="267" mass="29673" checksum="61B924E967D971F5" modified="2025-10-08" version="1">MSATQMQHPENKDVGNFRPTRPRCPIAAMYNSPGPAYMLPGLVGQPDHDYRSVHRKYPAWAFGIRHGKMKDDAGPGPAYLPTAKYYRDGPDGAPHYSLHDRRKDLTMFNTPGPGAYAPERSGPNTKYMPPQFSFGTRHRHRRTDNTPGPNVYSLPNMTGRTTESHKRSAPNYTLVGRSKQGGFDEDLARTPGPGTYKTPVPNIYKNAPPQYSMTSRNVMPGDGTVKPGPGAHSPETVYMTKKQAPKFSFGMRHTQYEAPLIVNPTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYL8</accession>
    <name>A0ABM0JYL8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101848058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005104600.1">
        <property type="nucleotide sequence ID" value="XM_005104543.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848058"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17978">
        <property type="entry name" value="DEXHc_DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="66"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="259"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005104600.1"/>
        </source>
    </evidence>
    <sequence length="690" mass="76697" checksum="3147C1422716F52A" modified="2025-10-08" version="1">MWHKHMHSPAKKPKVEHSSSNPGGSGWSGGGGFKNSPKLEGHGQPNEALKQERRALPIYPARQQLIAQIRRLPSAIVIGETGSGKTTQIPQYLLEAGVNGGAAIAITQPRRVAAVSVCQRVAQEKNTTVGTSVGYRIRFEDATSSSTKLIFMTDGMLLREAILDSKLTKYSVIVLDEAHERTVHTDVLFGVVKAAQNCRLKTGLKLLKIIVMSATMDVDHFSRYFNKAPVLYLEGRQFPIQVMHTAEPQSDYAFSSVVTLFKIHKEAPAREDVLIFLTGQDEIDSAVKQLRQLSRDMQDLPKLLILPLYAALPPQQQVKVFEKTPPGHRKVVIATNVAETSITIPGIKFVIDCGKVKAKVFNARTGLDILRVVNTSKAQTLQRTGRAGRESAGTCYRLFTEAQFGEMSSNTVPEIQRCNLSSVILQLMAMGISDVMTFDFMDKPDRESILAALTELELLGAVEKISESDMPKLTPLGKRMAAFPLDPKYAKIILLSQEYGCVEEVLTIVSILSVDDIFINQMNKRDEIQSVRQKFVSSEGDHITLLNTFRAFKSVNGNKAWCFENFINYRHINTAREVRKQLRDICSCQGIQFSSCGKDTENVRKCLAAGLFLNCAQLSKQGDFTTVSSRLTVSIHPASALFHCKPACVVYSELIKLGKNYMRNVSVVDPEWLQEVAPSYFKQKKVHLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYM5</accession>
    <name>A0ABM0JYM5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Abitram</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Actin-binding transcription modulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABITRAM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104620.1">
        <property type="nucleotide sequence ID" value="XM_005104563.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852343"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039169">
        <property type="entry name" value="Abitram"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651:SF0">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005104620.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20186" checksum="6373E52D1AE1C808" modified="2025-10-08" version="1">MAETQQSTNLEKPPPGVVERYFKKHFRIDLKGKKYEDQVVLTHSNRVCVVCIAESHPICSEKKEVIKVDFEVKGSNRMDNKMSGKAKRGAQWLGPTAVLCEVTCSDESKYTLYCCVKGQLVEVNENLITKPCLLTEKPLGAGYLAVMLPGLKHFDKEIAQLMCEEKYKKALEERSTNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYX1</accession>
    <name>A0ABM0JYX1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable G-protein coupled receptor B0563.6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101855359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005104803.1">
        <property type="nucleotide sequence ID" value="XM_005104746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855359"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="43"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005104803.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39927" checksum="38ACAF17D7D206FE" modified="2025-10-08" version="1">MNNHSSLGNKERAQLLSDETTHLVMQILMYGVTPTISTLGVLGNVFSIIVLLKHGLHKCSNILLFCLAIGDLVYLIAFNSVPKLLYELSGVAFAWDYNEVTAHTLFVLYSIFHFLDYAIGLSSLAIPMLITAERLVAVFLPMKFSRIITPARTWTAVGIICLFWIIVIFYSSLWSQFKYVFYPKLNISMGIIERSDRYFQEQDVGDVLEEMIKYLTLKIPPGLTLVGCVIIAVKIKMASAKRRKMTSNGAARETKSNRTSKILLSVCAMYTVTCAIVSLPNYLPQYGYYTMTGDAPNNVGRIGYQFFNIVGCTNSSCNFIVYVGMNKNFRDTWKSLFTPCGYIQKTANRQDRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYZ9</accession>
    <name>A0ABM0JYZ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104842.1">
        <property type="nucleotide sequence ID" value="XM_005104785.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864244"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029160">
        <property type="entry name" value="UQCC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35268">
        <property type="entry name" value="PROTEIN CCSMST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35268:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15013">
        <property type="entry name" value="CCSMST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104842.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21788" checksum="5174B8783C1280C7" modified="2025-10-08" version="1">MLMKFARSRSTLVFRLSQLQNCLPQCRQRCTTTTSFHCYGCQRQRTFAQQATSHHDVSLSESRSVHTGPALWKKKEISSEPIKFTTSAANVRSMPEPVDRNEYQGVIVAASLFVFLTYFLYLREENDLDEQLNVHLFDRVPGIEEPHLAQAIPRMKQLGLDTAEAEGRLKELVQERLKREEEEKKSTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ53</accession>
    <name>A0ABM0JZ53_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101850977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005104961.1">
        <property type="nucleotide sequence ID" value="XM_005104904.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850977"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005104961.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26249" checksum="A34CEC50A4D9CE63" modified="2025-10-08" version="1">MMAAPSENESGNDLQDRVEKFYEDAKGYWASVTPTVDGMLGGFAKISPTDINGSKSFLRQFLKISGGSLMPNRALDCGAGIGRITKRLLLPIFDTVDMVEQDQHFCDNAREFIGSDSSRVENIFCSGLQDFTPAEQGYDLIWCQWVLGHLEDDHLVKFFQRCQKGLREGGVLIVKENTLESDKRAFDDSDSSYTRPKWDLEMCMINAGLKVLSVQKQKGFPKDIYPVYMFALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ59</accession>
    <name>A0ABM0JZ59_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligosaccharyltransferase complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OSTC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104970.1">
        <property type="nucleotide sequence ID" value="XM_005104913.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853112"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042416">
        <property type="entry name" value="OSTC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160:SF4">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005104970.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16284" checksum="7A6783AC59359C64" modified="2025-10-08" version="1">MEALFSIPFSLLECPNLKLKKPSWVKQPSAMVVFAAVLTSYFLVTGGIIYDVIVEPPSIGSVPDEKGNSKPVAFMPYRVNGQYIMEGLASSFLFTLGGLGFVILDQTNKPLMPKLNRILLICVGGAAVVIAFFTCRVFMKIKLPGYMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K050</accession>
    <name>A0ABM0K050_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Steroid 17-alpha-hydroxylase/17,20 lyase isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101864543</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105623.1">
        <property type="nucleotide sequence ID" value="XM_005105566.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105624.1">
        <property type="nucleotide sequence ID" value="XM_005105567.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864543"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005105623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005105624.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="59287" checksum="E6EEA4B36AD4877B" modified="2025-10-08" version="1">MDACCLCTPWNLAVAAAVLCVLYVLSKQFVFRKGNPPPGPRGWKGFMEILQAGRDDSLYEAAWGWAEKYGDMTFYTVLGQPICILNSADIVRRLMGSDEYKLLTSDRDLNVVSEFAWYNGKELFFTPYNSQTRQKRTLFHKMMGIYGEGVDKFESVVGNELDRILEEMDTARATGQDIPISQILSRSLKIILYVLVNGDIDPEKLSLDVVDTMDRYDNAVNRMLDMQTLTALTFFPPLRKVGKYKKICDDVTESKIEAEKIMFEDLKSTYQEGKVRGIADAILHFQSQPGHEWLDDENVKGFLTATFFAAHMTTRASLLNMVLTLTHHPEVAQRIQEEIESVLGDRIPRVEDRLSMHYTEAVILENLRYVSQLALSSLRSAREDIHIDDQVIPKGTQFLVNQWFFHHDPKMWDDPWTFKPERFLDESGVILPANHPVRKKILPFGHGLRMCPGETFARSRIFLFMVMILQKFDLLPPENETLPSCDPRENLKGVIRQAPPFKCRLRNRREAESSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0E9</accession>
    <name>A0ABM0K0E9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105822.2">
        <property type="nucleotide sequence ID" value="XM_005105765.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850105"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005105822.2"/>
        </source>
    </evidence>
    <sequence length="701" mass="79400" checksum="4E0E341B3CC84700" modified="2025-10-08" version="1">MSSRALRRLQADSGLSDFHVDAPNGISEDSDVENDGDGASECNANDTNFTKKGKRDRRKKQKNATLNPFELLNEPDNEEPEENEVEEPDPELETTSVLKTEAKGAKKKKKKNKKGKEKVAPDLNGGCSEKDPIDEVEASVQEVNRILGDPGTACAAEDRSSIQFSVNMKPLLHIDYRNLNPDTEMKRMFGSDLFRGEQQQRHRRRRNRPVLRSTKLVQVKDTWHSTGGSGLSMKYLGEENGFVYEHSSAYQKFQHRFLDGIESGYPENIFNILQENPYHIDTLISLADFYNINEDFQTGAECIEKALYGMECAFHSMFNLAAGNCFLDFKRRENRAMFICLFKHIVNLGQRGCNRTAFEFCKVLLSLDPSNDPLNCLSMIDYYALRCEQYDYLLRLEAEVSYSSTQLQTPNFAFSVALAHFKLALRSNGDTSKADKMLQDKLLLYPMMLLPLLDKCSIQPDKRVSSHKFFHSDPAHEKSNELGRLVQLYVRRCEACWKESGVLQWLERNVNTVLDIVDEGVDSRLETYPALRRQQFKHPPPSILRHYHLSGIAVPSNVSNRTVYGHDPYPPSDSIAGYTRPPRPTRAAGSDQGMLSLLLESLLPSYNPYELVDVNSRRRQNPQENGFAMGAMDDGLGDDLGGAGARAIPQQLQTSVNAIMDAMRQLLNRAVAIPNADEQGEADEENERAWEEDEENYQNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0G7</accession>
    <name>A0ABM0K0G7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell death abnormality protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105855.1">
        <property type="nucleotide sequence ID" value="XM_005105798.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858124"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF12">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105855.1"/>
        </source>
    </evidence>
    <sequence length="595" mass="65550" checksum="1F780B6AFBC94032" modified="2025-10-08" version="1">MIVCCRTSPKFISLYFIWFTAIACVIIRHSMSQCLRGSGRIPCTVIVGQVDIKQSVEKHKATCKSYGMRLLELLSTEDKYAMKYFYKVAKNSLQSRSNTVGVLRSKDSDDAYYRSFSGPAFISKSPLWLDGQPDEDVRCVAITSDKVGEVGYEDYSCASQKYALCEACFVPNPTWTSCYFPYKCQFRNDLVCKIFREAKCIPVFFTNKTDYLPCPYNRYGCECESQCHCADNVPCDLYTGVCPAGCKKNWQGPNCNVTKCRVNKFGENCDKFCLCAGDLQCDLETGQCINGCPEGMSDRYCTKSECPPGKYGAECTLDCPCAEGATCDKNSGRCLSDSCLIKTRTLPFCTNISACEVGTYGKECEEKCPCLDGNACERNLGICSNEVCPAIGKGGLDCYDECPKELTCKRCLRLNMTKCGECVEGFRLTPNNTCEKGQQGPTKPWGSVAGFVAVSASNMWVIILIVVLLIVILVALVDIYIFLQKKDEHSEASQDGEKGLEEQSEQSSEKHEGASDKDEEESMQGSEDEEGDENPQTGEKKESSASSKKHSSASSKKHSSASSKKHSSASSKKQSNASKKQSNVSKMSTVSENLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K187</accession>
    <name>A0ABM0K187_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101861607</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106379.1">
        <property type="nucleotide sequence ID" value="XM_005106322.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861607"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15501">
        <property type="entry name" value="PHD_Int12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039054">
        <property type="entry name" value="Int12_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051776">
        <property type="entry name" value="Integrator_subunit_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415">
        <property type="entry name" value="NUCLEAR FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="445"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005106379.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="56217" checksum="8E9867D3D375FEB0" modified="2025-10-08" version="1">MTSSISGMAVVELDPVFVKALKLLHSKAKDSTAQLKFMLDDAIAQRKGLKAPSALSDFEKAISGKSKTEEDSKKREVEKRSSDKNSKDSSEPDSKKSKLDSSKSRSKDEKEAKEKERERERAKKEKEKKERDEKEAQRQREKAEKERKEKEASSAKPEIEAVVLSDDDGPASQMDAGDFAREMGIACVVCRQFDVSSGNQLVECQECHNLYHQECHKPPVTEEEISDPRFVWYCSRCARSLKKMVAQKPVKPKPALPTTSVAKDPVAPLSKISKPDTSSSTQAFRRIDPKAIVAPKETSSLSSTAKPMVGLAGLAANLAKPRNEAKGSSSSRKSDPKGDGSKSSKSDSKSGYKSDSSSKSSGKGDEKSSKSSSSKEEREKKSESGYKSSSKHDDAMSSKTSSSSSSSAHSKEDKKSESSKSSSGEHKWEKSDSKKSPAHHESSKSEPSLAKSSSSSSSAPSTPTTETAPALKSSSSSGGSSSSNKQAVANLSMVTANKRIQMMKKKAQTKPQDKKIHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1R8</accession>
    <name>A0ABM0K1R8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101856125</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106703.1">
        <property type="nucleotide sequence ID" value="XM_005106646.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005106704.1">
        <property type="nucleotide sequence ID" value="XM_005106647.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856125"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005106703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005106704.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26377" checksum="9E4FC046F38B4AA2" modified="2025-10-08" version="1">MKTKAEQCKEEGNKCMKENKHTEAVIHYTEAIKHEPNSAVLYSNRSLAFLKIDQLYFALDDAEKAIKLEPSWPKGFFRKGEVEFKGGNYTKALMSYRQAQLLDPTDEGITAAITKATREFARDKKDAARKPVLYSCIGLTVGVLIVAADSFLTVKPAIPHVVLQVLLVAGCGGIGFVAAKIYRYLTVSQRDALLEEPIDLLKEMGDDDGTKESSPSSSTSSHKHHSQAAGRQRMKKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K238</accession>
    <name>A0ABM0K238_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase-associated protein RTF1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005106940.1">
        <property type="nucleotide sequence ID" value="XM_005106883.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849402"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="7">
        <location>
            <begin position="319"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="498"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005106940.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="77489" checksum="5FC6C2833B297846" modified="2025-10-08" version="1">MSKRKKAVNMIDSDSDESGSGGEDVDEGLRALVKRRRTSSDSHSEAKANTTNAKSDSDSDTSNSDDDWTVNGKSGSKKKVKTKKPQKKAIASSDSEEEEEAKKSASEPEEGEVSDSGSDDSDSDEDKFHDGYDENLIGDDEDKKRLEAMTEKEREQELFNRMERRAALKKRFEIQKKLKKAKAAQKKVKPSSDPMLPTVSERSKERRKHIEQRKDNKKTSAFQDLKAKREEQKKKAEQIQAQKKIKASDIYSDDDDDDDNSSADEKSDKEERKKETKVSRASSVERADSDSEASERESSRSESEEEEVSRPRHRKIKYIATKEELSRIRLSRNKVERWCHMPFFKKVVCGCFVRIGIGNHDGRAVYRVAEIVDVVETAKVYQLGGTRTNKGLKLRHGAAERVYRLEFVSNQDFSDSEFNKWRYTMELGNHTLPTLDDIQRKEDDIKQGYEYKIKDKDIEEIVAEKQKFKKNPHNYAVKKSGLLKAKEQADLEGDQSGSMKLAQELEDLEERATELDRRRSSKINSISYINQRNRNRNMVEAEDAFKAEIEEMRNATADPFTRRHCRPTLVTRQARAEAEMKKGQDGNASAVKTAAPVDASSLPALPVSKLALSDHGKGGDKPDGPERRTSEDLFAVHDFDITIDLDVPSGGAPVVVPTAATLNPRDSAPKRSLNLEAYKKRRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2W6</accession>
    <name>A0ABM0K2W6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein lin-37 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107502.1">
        <property type="nucleotide sequence ID" value="XM_005107445.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864326"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028226">
        <property type="entry name" value="LIN37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31336">
        <property type="entry name" value="LIN37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31336:SF3">
        <property type="entry name" value="PROTEIN LIN-37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15306">
        <property type="entry name" value="LIN37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107502.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26482" checksum="E023130F78F05A8E" modified="2025-10-08" version="1">MASKGKQEVNSARIRLDATLQHLVDRKEDGQSQSEGEGSMPLPDSRISASPKKSASKPNRKRKRRDDSGEYDGIGEQQTVIMKLFDRSVDLAQFPESSPLYPVCRAWIHNRPHDKSLGTLADRASSPDVKVKEEERSDSYSDVYELPLPIKSEDGCLYDLRVPEAVPQPDERLNIHADPLSAPPAEHLLLNHMARWKEVRNRWHEASVMNEMQYASSIQVLKEMFERNMADSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3L0</accession>
    <name>A0ABM0K3L0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dual specificity protein kinase Ttk</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107958.1">
        <property type="nucleotide sequence ID" value="XM_005107901.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850751"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="632"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005107958.1"/>
        </source>
    </evidence>
    <sequence length="908" mass="99602" checksum="DDAA8D8BE1C4B6E5" modified="2025-10-08" version="1">MNGPTGFTASGPSAISLNYKEQMEKIAANGNRPEDWKEYIDLIKERIDLLDESRKNKTLAYLYYNAFKVIPESCKSLSRAQLLVDYAEFKGQQDEGDAEKLLSLGRRTLRHHSVVHIACAEFEVKRGNTEKAIKILKQARSIGSVPMVDINVALERIKEGKMKLTDSASKRNLGATWQSPDSGRESSGECSSLQLSGYFEGSRECLQQALPGCKSNTQEVQQGLDYITQCVQAEGSDLSAQPAAASHQHVGLPQTPISRQPPDPPHLLSSHYKDLSFLCWRTRNPSSMHPTSSSSSALASTPAPALPASSLGFLSSSTPSSAWAPGQTAGPSSHLSRPERSALSSENGQPVGESGTAKRSLHHFHSIPDMRSKAASAVKEPARKPIGRGIPPRRVPKTLHEEKESNDDKVGEITVSAFERLDLPPKSATIDCSGLKSENTERENSKLLSGHGEQIVNSSRTNEPFAAFAADPTASMNTHSTVRQPPSTNLYDAHRVVNPCAKDSSDSSSKASELNERDKIPSTHISASSSTEKCPLSRDRNKTGNKENFVAMNTDRNMDIVNENRILSPLKQNRVEPPVLAPKLPDEILPSGDGQAKINNATYTAQQAPVQTPAKSCEQMAQKTKQVNGKCYPVMRLAGRGGSAKVFQVLDMENCMIRALKVVDLSGDNRLILEGYMNEIGLLQKLNGCDRVIKLFDWEYSESSKKLMMVLEFGETDLAKFIAQNAKNTDELHSITICYFWGQMVKAVHAMHKEGVIHSDLKPANFILVSGAVKLIDFGIAKALQVDKTSVLKENMVGTPSYMSPEALIASSADPAGNKPRYKVGVRSDVWSLGCILYQMVYGRTPFQHLRHKLDAIVNPSHTIAFPGVDDQALMDILKKCLTRDVRLRPTTDELLVHPYLKKEPRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K455</accession>
    <name>A0ABM0K455_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101857366</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005108328.2">
        <property type="nucleotide sequence ID" value="XM_005108271.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857366"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17971">
        <property type="entry name" value="DEXHc_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044762">
        <property type="entry name" value="DHX8/Prp22_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="314"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="624"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="805"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="380"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005108328.2"/>
        </source>
    </evidence>
    <sequence length="1275" mass="145523" checksum="BA00E8262643421D" modified="2025-10-08" version="1">MEELEKLEYLSLVSKVCTELENHLGINDKDLAEYVIELADKNGTFATFKKALEERDALFSDSLIANLLRLIQKMKPKQKEKSFEESEREEDKKVDVDLNRQLFPGLALADDPKVRSMLDDDEVLSSDEEKQSSKLKPSSSSTKEEKSVTSKGEGGDQSVADSMMLELEALLGKASGKTKESKDKDGGSRSKNRRSRSRSKDRDRDRKRKKRSRSRDRSRSRSPARRRDRDRERDRDRDRSRDRDRDRSRDRDRDRDRDRDRHRDRRHRRDSRSRSGSRDRDRRHRDRAERKTRDSDKAKEKEKYNDIPLEPVVGSIYEGKVTSILPFGCFVQLEGLRKRWEGLVHISQLRREGRVINVSDVVNRGQKVKAKVLSFTGNKPSLSIKDVDQSTGEDLNPSRVRVGGEVKDGEENSARNPDRPSTLPLVDAPELEDEKSEMKTFKRLSSPQRWELKQMMAANCIDITAHPDFDEETGLLPKEDDSDEDVEVEMVEEEPPFLQGHGRQWVELSPVKIVKNPDGSLAQSAMMGNALQKERREMKQAQREAEVSTVPAGLNNDWIDPMPEDGGRTLAANMRGVGMAPKEEPEWKKHISGGAKASYGKKENKTIIEQRQSLPIFKLKDDLLKAVHDNQVLIVIGETGSGKTTQITQYLAEAGYTTRGKIGCTQPRRVAAMSVAKRVSEEFGCRLGQEVGYTIRFEDCTSPETKIKYMTDGMLLREHLIDGEMTQYAIIMLDEAHERSIHTDVLFGLLKQAVKKRPDLKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVAILYTKEAETDYLDASLITVMQIHLTEPPGDVLLFLTGQEEIDTACEILYERMKALGPEVPELLILPVYSALPSEMQTRIFEPAPPGSRKVIIATNIAETSLTIDGIYYVVDPGFVKQNVYNSKTGMDQLIVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLSTNVPEIQRTNLASTVLSLKAMGINDLLAFDFMDAPPMQTLISAMEQLHALSALDDEGLLTRLGRRMAEFPLEPMLSKMLIMSVHLACSDEILTIVSMLSVQNVFYRPKDKQAIADSKKAKFHQSEGDHLTLLAVYNSWKNNKFSSPWCYENFVQIRTLKRAQDVRKQMLGIMDRHKLDVVSCGKNTVRVQKAICSGFFRNAAKKDPQEGYKTIVDSQVVYIHPSSALFNRQPDWVIYHELVLTTKEYMREVTAIDPKWLVEFAPKFFRHSDPTRLSKQKKQQKIEPLYNKYEEPNSWRISRAFRKFHTKVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K535</accession>
    <name>A0ABM0K535_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-uridine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TDD superfamily. DTWD2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005108956.2">
        <property type="nucleotide sequence ID" value="XM_005108899.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845358"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039262">
        <property type="entry name" value="DTWD2/TAPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392:SF0">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="7">
        <location>
            <begin position="43"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005108956.2"/>
        </source>
    </evidence>
    <sequence length="275" mass="30927" checksum="69A9B59BDDFC54B7" modified="2025-10-08" version="1">MRVTPPCNMAAAGDNENNDNELLLVDDFACLDVFESDSDSTSKRPTCQRCKRPLTVCLCPFLPREPLEIKTTIYILQHPFEESRCLRTVPILQNSVPADRCQIFRGKRFSKSRFPDLVPILESANTVLLYPGDDAVDISELPTGQTYNLVLLDGTWAQAKGIYTQNEYVRNMRKVKIRAEQKSKYVIRTQPSDTSLSTLETAAIAVATLERKPEIAETLLQPLVALCDFQLQHGATTHQSREYQMEHGLWTKPMSRADHRKLAKKCAGEQGSPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5B4</accession>
    <name>A0ABM0K5B4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101860848</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101860848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109100.1">
        <property type="nucleotide sequence ID" value="XM_005109043.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860848"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487:SF1">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005109100.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33176" checksum="D99D63C25A34750B" modified="2025-10-08" version="1">MATQVTDYRLEINESRFRAESYFPGITYDDFDRAGGISPWKICRMFEAGRNVPFYQGNFLELQDLRSENFGFYVLGGDYYFDPCVWEVARKYQYFPYKISIELINQGETSLTFREILINTLDGKEIATFYGKLVYVDKSAKRSQVLPYWHRMKYRSVESPDRVRIDFTLSQVPSDACRVKTLVSASDVDHNGHTNQASYVRFCMDAAESVNRRKQLKRFSGDICLYPIMKLSTAYRSETYVGDELSTCLWQDDLSPFMIHFVLFREDTIVFSATVTFKNAPCSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5G9</accession>
    <name>A0ABM0K5G9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 216 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101861076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005109190.1">
        <property type="nucleotide sequence ID" value="XM_005109133.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861076"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF0">
        <property type="entry name" value="GEO07735P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005109190.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17440" checksum="7F9BC96B16739B92" modified="2025-10-08" version="1">MAAEQAQTSTQAPPRRGKSQVVRSSLPFQILLYLNGWYFVFFFVCEILLFVFKGETLPYASNVLAAEILLLFLLAIIEGLRLFFGRRGNLTEQIVGVIVFLVLSVPTIFGVLFFWLWQTYVLRAEVILTAIQIAFIGLEIIIGIISMITFAKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6Z0</accession>
    <name>A0ABM0K6Z0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101855831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110189.1">
        <property type="nucleotide sequence ID" value="XM_005110132.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855831"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="321"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110189.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="66962" checksum="D837CE35E8C7E43C" modified="2025-10-08" version="1">MGGTKKKKYERGAATAFVSRNKALKKLQLSLPDFRTLCVFKGIYPVEPLHKKKVNKGSTAIKTYYNLKDIQFLSHEPLINKFREKKHYVRRLKKAIAKKNRFAESIIRDNKPVYSLKSVIKERYPSFTDALRDLDDCLNLSFVFASLPHSKLIHVDLVQLCRKRTVEFQHFVMATKALRKVFVSIKGIYYQADIKGETITWVVSHKRGHQHPQEVDYKIMKTFAEYHSVLLGHINIKLYSDSHLVYPPQIEEEIGYVSKKFCLEGDKMDEHLACLSLPIKSAGDFVEEEEDDPEVDQLNAATEDDPDFVEKSKLEAESVRQLQSLFKGLKFFLGREVPRDELTFVIRSCSGQASWDDMLGLGATYEESDDCVTHQIVDRPAVQNQRLDRTYVQPQWVFDCINARVLLPVKDYFPGVPCPPHLSPFVEEKEGEYVPEDKVKFLNRIKGLDEAEEDESEPEDSEEEEEEEEEEEEKPKSRKRQRQDTEEAETEGKVAKKSKVNSMAVTEGRVEKVDKGKLLARQQAEEKRLGEMMIPKKHRRLYHKIMTSKKKSSQEAKKLQEKKDKITKEKKKKKKQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7C3</accession>
    <name>A0ABM0K7C3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tachykinin-like peptides receptor 86C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101864569</name>
    </gene>
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        </source>
    </evidence>
    <sequence length="2306" mass="253423" checksum="FDDA92A1E8432436" modified="2025-10-08" version="1">MTSSTPSSGPPVSATPTAHVMGVTEGQALDNFLKDILWFVYDYQLLLILCLPVLALNWWALRILRQFRHGRTVLDATGWRELVNTSNVGLDNTAGFAPHVVFPDHLPAHKDYFVYHRRKRGYGPATQKSSALLTPPTSRAPFSSPSDHRELQSPSPSMSPSPQVELPPMSHLLPSDESECESEDRDCMSPDFSGSATMLRDNDETLNEITWAFDSSPSAYRSRTNVITESHEISKRKKLAVDPDKFLKGNIGGHGNQQTRVRERGRRSESEEARWMHVDRAHGERAVNTNPRKESNRSLSLPKDLRTAACRNDFGPSKTSPCKDNRWRSTVAQSPPSPAVKIRKISKSPGGGGVLVNSNKWGRRSRKLAACTINQKQGTASGQQLMSHRSSDSEEAFVHLTCCPEPSCRSADTTEPQASRNRSETNLVYKRDSWIWFSPETRPSVESFATRQRKFQSSDPRVARLAAEIKRQEKLNRDIERKAESMIESSSVSSDRVFRADAAKGKKRTDLPRGSALPPVNSSDHSPTVNRSKNRSHSVPSALVSRHNAACKKQQGVITSKMNFRGFEKNARSPKMLHEGARVRENSASPSRKDGRSPKRKQSAHHPETEARTPAPRSASNNSRGILQLPGRWTESRLRTASLSPLRNESLSPQREAQLGPRTKGSQGFQTQVPSRQRNLLNRQGTFSGNSSKPNEGIISKASIFSSRQITRSIRFEKSPHAGSPQRRPVDFGDEGLNTYSPRARSPDKSGQERAGAGVGSVRVLESPLRVSVSPSASRRRGGEKEAQSQGDMTSALFSTTDTGTSRLKSPSVVLSTGESETESAFLNRSGHVCQVVQKVINREVKDVVRSLLTDPEQSSSSHTSKNRHYDEKQQQQQQQQQQQQQHHHQQQKPTPTTRSENTHSEEELSPTQRRPNKKQQNDAACRFGNNGNSLGSERHHGGSKCSPPSRKPASRAADSTESPLSDVGVNTSQYEDMMSNEARTFNSKIPVAIRSYSASPQEWKRQNSPLVQVTNHVSGQGDARRINIYTPEYYLGRMSPKGPIRKTPDSPQHDMSPFEPVKNKAKCLTMQNQEEPAIKVSYQKPIQAAASRVHSPAMCDGKRYTQQQSPGSKAVKGVVQKKKTRFMPVNKSTLLMNTLNGRDSENTIRHRATKESCDKRSGSLGFSNENKTGVQTDSQRCQKWEHVWRETSEGVDPMSALSSWSQDSDASVRDNEKRAAAPVRFNKRREEGPSADRKSSTTAVVGASTNNSSSYLPYKGCPALRPHVGKCDARSTQYQYHSRGESRCQMDDIKAPNLCTSTAALTNVQVSHVDTFAHTNKNKHCPPLPVWPRPVHTRGSEACAGTLTHIRAGAATPGPLRAMKKRHLCWTKRNLGASHRDTTCGIYEQRSNIHESLGIGKKFACLYGKRRAVSRNKTEDQSLLSVNTAQSGIFSNDVSKPNKMTYSVFRRGLQIQEKKDELVRPDSREVDESFLLNRVSGVGKFRAAHRVMLPPTSSDEESEEADRNCQILQKQNSFSATEGSQITDLVQPSIKLEADVLVPNSNPDSGYEESVSDKTMPLSDKTMHLSDKTIPVSDKTKPVSDRIMPASDVLGKTMPVSVKTLPVSDKSMPVLGRTKSALDKTTRVRHEVMVTEKRPPPSTSALPETQNAATDEPGVWEAAPGTSTSSRSDSRSSEDAAQRSPWSADGAMDQTTLSSVSEPAAWSCDLCDHTDLCDPTDPGHLGDNGDPMDLNNGSDPGDSCNSLARNSAEDEDTKPTDQDTLPSVSEISCWSWESVSSVEYNTRGQTEEPERSSAATAGNSKSSSRDHLGCAEGASVPPEISNTGPDPSLCKAKVNCWSQEMCSLVQCVSRAEGEDTNQDSRVVTRGEGGFSYGVKSSTPSDVQASRIPEGQAFSSNRPSSFSFCGMFRSVESGGLGVSKNAADEQPGGDRVTDSGPSNLTSAACPGQFSTEPDIDLHNTTLHTSHDGSGIYYEAEENSVSFSDLTGLSSTSLSNLLEDVSDFPSDISLQSLCCSSYLSPQVSSTQPTQSFHVPPTRPVAKLPMNRDSPAIHQRGDLDRRCGGDIVKEKVLIHKDDKNTTSLTDFLKSSNRFPPVLSAKQKPLESDNVPGDFVCGIIARTVPLPLTSSDDEEDEERPRRNYDEGVSDVRKKTHHFLDRSSKISEGVPESHGFETPCSGSCESKRSPGTFSKEDMESTTPPDRGSSLSVGSGQQSNTYGTVLSLDFPKSVGDPKTDLTEKSHRHAPCPASSEIQLSGEKASCEVATGEQQLTQEEEDLDCQPEHRRPIHFQRSMPFAELLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAC9</accession>
    <name>A0ABM0KAC9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101862161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101862161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112760.2">
        <property type="nucleotide sequence ID" value="XM_005112703.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862161"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005112760.2"/>
        </source>
    </evidence>
    <sequence length="139" mass="15329" checksum="EDF01F1E9DA6F72D" modified="2025-10-08" version="1">MGANKQTGIGQHTFAPVTMVSHSLKIQGVFLERMVNEMSEDQGKGLAHDGMMSLVKSFCHTSPIWSHFTLITLSNKSAFAPADKQIYMDNFSTRCTRLKDLSHQGIRAAGMLRTDRKTGEACPVTCCQKPSSCSLKFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAQ5</accession>
    <name>A0ABM0KAQ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major egg antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005113030.1">
        <property type="nucleotide sequence ID" value="XM_005112973.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856400"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="70"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="186"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005113030.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36787" checksum="4FA194FD9642FAAF" modified="2025-10-08" version="1">MATRYISEIHVPIKKDDMSFQDRQIKQWGEMETRMQERRKLWEDEFDRMRRDFFTLKPAEKSPQALASINLDTGMKSMFEADADGVQRFKVRFEVSEFQPEEIQVKVQDNKLIVNARHEEKSAQTSVSREYSRQVDIPSSVDQEKMQCVLSKDGILSVDAPTTQPSLTGSDAIFPVKSSPPVKSLDVATPVKNPIITEADGSRKLRLQVDIGEFSPEDVVVKTMDRKLIVHAEHEEKTAGRTLHKEFNKEYDLPESVDPATIQAYIADDKKLTIEAPLKPAQRKLYSVTQSQDVRKVVVTKESSVTITDGQNRPVVTISVHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAX9</accession>
    <name>A0ABM0KAX9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">cAMP-regulated phosphoprotein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101861262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005113205.1">
        <property type="nucleotide sequence ID" value="XM_005113148.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861262"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3 4" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005113205.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14816" checksum="7FA7D87E0A6E4B9B" modified="2025-10-08" version="1">MASDATEERTSTPCETVREEDEDNVNDELPPQPQPDKKVIEQREEEKLKSKYPSLAKGGGGSALLNKRLQKGGQKYFDSGDYAMAKAKLSAKQKPPPPPEKIIKAEAVGETIPTPENIQARKPSLVTSKLASGELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUA7</accession>
    <name>A0ABM0ZUA7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tigger transposable element-derived protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106011021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934611.1">
        <property type="nucleotide sequence ID" value="XM_013079157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011021"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012934611.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="64704" checksum="05DDE9E5498BF66D" modified="2025-10-08" version="1">MEEAVKLVRSKSMTLYGASKTFKIPLSTLGDKVRGRRAVKPQVHKLLTDEEEERLVMWIKVHAQRSMGRTHEDVRQKVKEILDLRGASVRREDGLPGRDWVTNFKKRHPGLSLRSPQALGKERALVQEKDIRDWFSEMKKYLDSRDPALLKSPDRIFNADETGFAFAPVSKRVLAPVGMKHVYNICNNTKNQITVLACASAAGEYVNPLLVFPRKRMPSANFLAGFKDAFMQLSSNGWVNVTIFHTFIKDVFTPFIAEKPKPVVLFVDGHTSHNSDIGTLKMCEEHGIILYGLLPHASHIIQPLDLSVFGSMKARWSVVVKQHLEETGETPSAANFSHLLKKVWEHCATPEASLKGFRRSGIFPFNPESPLTSGKMEASRSFFSSPEDTALPQVATTKLDAVSSLLRLSSMLGIIRCESYLDMLKERKTSEDKEFQEFQRTLVAAGVLEVQDQGIPASSVPSRRKSLDDLFAPPQLPKNKRGTASKKNSSLTMAFSSDQYRNFLQGKEDKARMEKEMKERRKKDREEAKARKEQEKKERQEKARVERERKKQEKKETQERKQCDFVTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVS9</accession>
    <name>A0ABM0ZVS9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Major facilitator superfamily domain-containing protein 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101845078</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005094141.1">
        <property type="nucleotide sequence ID" value="XM_005094084.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012935568.1">
        <property type="nucleotide sequence ID" value="XM_013080114.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845078"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17485">
        <property type="entry name" value="MFS_MFSD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005094141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012935568.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="48566" checksum="00A8969A51F2C658" modified="2025-10-08" version="1">MNVVRSSSSQEYKTRIRTFFVLYFLQGLPHGLQSGFLPLFFRAHGMSLANVSLYKLLLIPWVLKAVWAPIVDLYGHKKLWLTWSLIALIFISVTASNVSPSDYTSLTGILFIFNLITSVQDIAVDAFLIDVLTPTQLATGNTAQVVGYKAGSLFAGGVFAWFIDLLSLRVIFITLAILYTLGLLVNITYLPYTDSAKVHQISPNAQQRTSTNNLVTGTVQPNATNQSQSLSHGDGRWFFLKMFETDGTLWMLAFMLLYKTGENGVTNLLPLFLLDEGVHAHDVGFWTGMVGQGMSILGSAVGGFIFTSSMTTSLQIQLTSRTVSVLFIWLSVLLWSSSFPFVNGSCIFFLMVLFFFGGAVTTCTFTLVMQLSQKAPQKYRASYYTMLTTTEVIGKLFFSAAVGTLAQYTSYSFAFGLFSFLSIMILPMIFQAPQVVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWW3</accession>
    <name>A0ABM0ZWW3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011365</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936175.2">
        <property type="nucleotide sequence ID" value="XM_013080721.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011365"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005049">
        <property type="entry name" value="STL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362:SF0">
        <property type="entry name" value="EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362">
        <property type="entry name" value="GLYCOSYLTRANSFERASE STELLO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03385">
        <property type="entry name" value="STELLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936175.2"/>
        </source>
    </evidence>
    <sequence length="725" mass="83770" checksum="E49066C0ACEC0640" modified="2025-10-08" version="1">MVALLVFRCQRRLGRVTSLALLLVVSTMIYVLLVPDYIYLRSSAHALYWVLPTAHSDVFTMMNFSTFSNWTFLLPKDVGSEARCSGCTSPDDTIRDYIQKWTYDLDLPSESPMADQFSRMASALFALDHGGVGVLFTSDVSSFEVSKNRLIPDNQPDGVKGIEYYGLNLTLDSFHFHHRIKVGPGNPCLYRIRKRMKPLWTVGVRCRAHKQKGIDTLTLIDQHAPPVYTSEPRVNVLEYSDSFFDYEGLWAMFMSFVPSGETSGIWGLWAQRLLQELGAEMALTSLPCPNSATLSIMPGTPSSESQKVFKFVNSWVCPHQYSFYECAILLAEELHARNFVVLNDVQQLRIWFEGLKRLGYLEPKRRELVPRIHDLLLGCVIHSPALVTASSNPSPVKQFPAIEPMCKNLTARSGVLDPFKNYTLDPNSSRVKDIALVIIFYDASIYSNVQFLEDLYRKYFRTLIYCGPDSNVFQTFYKTFKKPITYVEVPDTQGFLAYECVSRAVMINYDVRGYLEMADDVILNTWTLGSIPRDRFWFQKDLRIASRHQQMMLDFALNYPFPWWPWTVHGQMWGAKAMAKVWKTFEFIRASNNSGAKEIVNVFLDTLKQNSGEPDNFFYCSSDIFYVPARHRQAWAMLSDIFFSNNVFLDIAVPTLINGMELTTDIVRMDGVYLWYTERANYPSYYREFHQFFHPWKMGWIQQKDHANFMCYYILPHIVKDLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ76</accession>
    <name>A0ABM0ZZ76_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear pore complex protein Nup214</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847336</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012937553.1">
        <property type="nucleotide sequence ID" value="XM_013082099.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847336"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF46">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="614"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="930"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1018"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1076"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1203"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1344"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1380"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1478"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1613"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1824"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1949"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2159"/>
            <end position="2188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2201"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="516"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1126"/>
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        <location>
            <begin position="1207"/>
            <end position="1244"/>
        </location>
    </feature>
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            <end position="1366"/>
        </location>
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        <location>
            <begin position="1408"/>
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        </location>
    </feature>
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        <location>
            <begin position="1501"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1518"/>
            <end position="1542"/>
        </location>
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        <location>
            <begin position="1543"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1555"/>
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        </location>
    </feature>
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        <location>
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            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1644"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1664"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1682"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1706"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1740"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1782"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1824"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1880"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1901"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1923"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1983"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2015"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="2031"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2053"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="2072"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2159"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2203"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2216"/>
            <end position="2231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="2232"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="2264"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2276"/>
            <end position="2290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012937553.1"/>
        </source>
    </evidence>
    <sequence length="2290" mass="229652" checksum="809675AD6F0E61ED" modified="2025-10-08" version="1">MSVEPPERDVKDFEFIQLCKFRIAPPDPDVSTSRLKLLACSSQYGLLFYGTKQGFYAVKTSELMAIDEKLGKERTKVVISDIPLQYNVPLNSPVLSLDCSGDGKTLAVIVKEVGQLDVLLYDVRAFLDKNCAIPGPFTQTRLQAAPSACVVDSAWNPAFFNLLSLCLSDGSVQLLEVKERAVLVASLPSTVAATCFCWSPKGKQLLVGKKDGSFTQYDHIMVEKRQWPCPNVLNGPHAAVDVVWQSTYVFMAAFLQAGAPPADQPSVVMTSSNKENNTTYINFEDVCYGNGESRKPKYFFHFVQKWEMILMASSNATETTVVGKNLDDKVNWEHWNLEDCSRAELPLTDDKNDSYPNGLAVDYSPQKDVVLSESKTFPACPVMYLLSTDGILMAYHLIYAHKDAPPITADVLPVGNVLEIRKGAPPVLSQQARPGIFQSPQAGSSGSVFGSPAMTQATNTASPASVPTPPAQPAPSPQQVPSSGRAASTPLGTSALGPSFQFAGLGAKTTTASPAPALAPAAATTTPGNQKPPLLFPSLASSSSAPSSSSGGQAGSQTTLGQPKASNFPFSFGSPATSTVQSSAFSFVPASSTTGITAAGGVAPTQAQTAVRFGSSLPKPSLPQGQAASSGSPALASMLGTPPKQEAKPSQPQQVPDAASQQRKGPPAMGSFPPQQQDAPSAFSFQPAPQAPTAQPGPATATPPRPGFVSQPSPAALSAARAVPAQPSGGGVGSQRSIEATVDDAFTQNILEEMKDFNKELQDFRQRSCRDVKTVGTKEEMQTLRQDSEKMNNFLLEIKDTTKEQQRESQEQKSFCFNLFAMAEECRVKQERDSDPHYHSLLQGRTLDPASAEKLKNLQQLCQTIEQCVVEVDGILDRQWQEHLDKKKSQQRLRTPTGDTIYKSVRNNNMLIAGQRRQLEKLEEQLRNVKLYTSSPGKQTRGQERSKSKLMSPMTPGSESRKPEKTLTSAVAAGMTPEKISRLRDVLSQRKVPTVKSTVPANLSKSRIVSQTPAANLSALSPQPTQGSQSAGPAAHTPLPSLPPMMTPKGFPDRPLRVQKGLPLMDQLQQSPAPVTQVLGQGQTPVKSSPLAASAASVDSPRQQHQQGPPPPAPTAFSGTAFFKHQPQPQQQQQPGLHRFAAHGPSVASGPVDPAVGMSSAPVSVPAVGMSSAPVSVPAVGMSSAPLSVPAVVGVGSLSRQLLPPTEYEDITPTETDETNDEDEDDYDEEDNGYEDEDEDEDEAGLVGMGRVSGSVVFPGAVGPAGADRGMSLGPSALTAAATTAGLFKPPSSGAALGATRQAFTPVRPLDAPFGADNAGDASTRAPPAVKDLFGSKSAAATTSVTPATSATVAGDSNKSEASSRSGSVGFAFNMAAAAKDGGGAPEEGSNADRFSFTTTQSQPPPVASSNAAATTTASSSSSSSSAFSGSLFGQRSETTSGFSFGGPALFGSKMSPGTAASGSGGAVFGSVATPSKGFGFSDLAKPEGKSDTPAVGPSDKVPDGQESSAKDAQKNLSAAAGTTAATAASSRASPATVSSATDSNATQEGSSVTGSIFGGKKSSGGSPFAASSSPGESGPSMFGGKSVSPPGGKFGFSLIPSSSASTAATFPFGASAATTPPSTTSGAQQQSVVDTGAGGDNPSTSSFSFTATAAAQKSPRDAPSSTTSTAETGKATESSDSVVGTTLSSGQTGSASSAGSGTTDAPVSSAESQKPASIFGTVPTASSSASSGTSGGFLFGSTPASTATSSTPASTTPSLFGQPAAASSSSSDTPLFGSGGTTAASTTASETSTTSTSLFGGDSSNPTTASSSLFGALSASIPSTVSSSASSSPFGAVPGTTSSSSSVFGGFGSTAGSVSQSSSSPFASVPGASSSGSSVFGGGSGPATGGAPLFGTSTVPSSKPFGFGAPSSGSAGSGGLFGSASTPASSAAGTGLFGSSAGSGSLFGNSASSATTDTTKPSGGLFGTPATSTSVFGANPATSQQGTGFSQQSSPAFGFGQSSAGTSGFGQTSGFGQSTVSSSSSAGSLFGSGSGFGGLGGKPSEEKAKQNVFGTPQTFGNGATQSQGLFGNEGGSTFGGAGSSSPFGGGGGGGGGMGGGGFSTGGQGVAAAGFGVSSANQASSSGFGGSPAFGGSPSFGSTSSFGASKPGGFGSSPAFGSSAAFSSAPSFSGSLGQQSSFGSSGGGFSGFANAASPSFGSLAQSSPSTSVFGDSSAGSGFGTSQTQSSPFGGGGGGFGSPQPFGGGGSGGGSLFGQSSASPGFGGGQTQGFGGNSSFSANPAFSSYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZT3</accession>
    <name>A0ABM0ZZT3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850169</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937912.2">
        <property type="nucleotide sequence ID" value="XM_013082458.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850169"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF41">
        <property type="entry name" value="PROTEIN CED-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937912.2"/>
        </source>
    </evidence>
    <sequence length="242" mass="27945" checksum="922F1DFCB92E7378" modified="2025-10-08" version="1">MALFTYNLMMPFCGNRHMNLVVAVWLVGLFFEQLYLAVVKRWHFGRVSIVANVRYMLVMLVTLALIVVFRILYWPVLPFFIVKIFLCFSLIYFFYYAMGYFFPVSKTLGPMLINITVMMRRDLVKWLRIWSMTLISGAVAVHAVLYPAAPFNLNTLWSAFIRGVFALFTTDISDLDTDDPVCACLYHETGEKGCRAPEQVGSEVLKKIERCPYQSHGGYVITLQYIFITKLIFGTLIFAICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0Z5</accession>
    <name>A0ABM1A0Z5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminopeptidase W07G4.4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106011924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938616.1">
        <property type="nucleotide sequence ID" value="XM_013083162.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011924"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045074653" evidence="6">
        <location>
            <begin position="22"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="7">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012938616.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="72690" checksum="6EDCC7F7530F0559" modified="2025-10-08" version="1">MPPPPPLLLLLLASWVAAPTAFVIEKDQLVTEETPTNVLNDAVNLHLDQQNITLTTDVQSADFDAVVVITDTPDNLIGENLVPVKEVIQRYLAADKVFGTSPAVTLTDVVASKRLVYASVGSLEGDENDVRTFAEAAARGVRRALLAGSKRPLLVCAPPPGDKRYTSAFFVAVLGVLQELYQPLSVRESDKEAPVEVLGLWHDGLNSPATSTALRVVQAIEAGRLVARDICGADPERMAPPKVEEYLSQVFADTGVSMYSTSNQEDIQREFPLVAAVSRAAQPVTRHRPRIVKLMFSGPGEVNRTLLFAGKGVTYDSGGADIKYGGSMASMSRDKCGAAAVVGIVKALHILQPPNLRVIAAIPLVRNSVGANSYVSDEVITARSGVRIRIGNTDAEGRLILADALCRLKEMAQYAPNPHIISIATLTGHAESTGGNHYSMLLDNEPARAKHIADSLQATGDKVGDPFEISRIRREDFQAHKATSDPEADLVSAVNNPYSRRKRGHQKPTAFLLQASGLDKHGSSSKHSLGFSHVDIAGPAMIFPVNPVPAPVVAMVTHFGLSREDKLLVGVLAEGESGEESEVGAEKDGEGEGEEEEAEAEVGEEEEEEEEGGIGEGEEVAGEEGLEEGEDEEDEVEEEDEEDEVEDEEEEVVYWGEEMEEELEDEAEEEVGQNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1Z6</accession>
    <name>A0ABM1A1Z6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="12">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101864153</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="12"/>
    <dbReference type="RefSeq" id="XP_012939199.2">
        <property type="nucleotide sequence ID" value="XM_013083745.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864153"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF218">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1132"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1165"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="15">
        <location>
            <begin position="989"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="537"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012939199.2"/>
        </source>
    </evidence>
    <sequence length="1213" mass="136594" checksum="EB4D790EB0158077" modified="2025-10-08" version="1">MGNFLNSCLPGRGVKPQVRPIVPNHTVDENISIKKKSHPNHGYSNNFIKTTRYTLLTFLPKNLFEQFHRFANIYFIFVVALNWIPQVQAFAKEVAALPVLFVLLVTALKDAFEDFRRYRSDKKVNSIACRVFDVKEKRYVKREWAHIFAGDFVHLSCNEIIPADILFLRSSDPQGICHIETSNLDGESNLKQRQIVEQFANVAKREDFSPTMFPYTVDVDEPNSEIYSFKGSINMDGGTKASLNSSNLLLRGCSIRNTDFIEGLVVYAGGETKAMLNNRGPRYKISKLEGKINRDVIWCVILLLFLCFFCAIGSGIWLADYNNLTENTNLVPFIAFGDLDQYSPLYQGFIVFWTYIIIFQSVIPLPLYVSLELVKLGQIYFIMQDIEMYEEDSDKPMECRALNITEDLGQIEYIFSDKTGTLTENRMEFKSCTVGGVNYPHLPCGDESSSHSDYNSRQSFTAYSRASSTIENLYLEPALQRELSNMCLRSLDSAELTIPLHVKRVQEFFFLMAVCNTVVVSYIHEDAMDESGYVTEAVSPKKGSTPGTSTSRESLNVSGGGTLGSTRSSDSLDRPAPHTRMQGGLTPLKSRSLLSLSASESGGDFMSEGSVTGSSFISEGSARMHYEAESPDELALVKAASTYGCKLKGRSPGKAKVFLPADNEEVELDVLNVLHFDAVRKRMSVIVRHIKSRTIILYIKGADSAILEILHSRYESDEDDKRVKTMTLEHLNSYAMKGLRTLCMGKRELDAATYERWAVEHRKAESSMNNRDELILESCLAIEKDIELLGATGIEDKLQDGVPSTIHKLREAGIKVWVLTGDKQETAAQIAYACHLFSSDQELLKINADTKEATKERLDEILADIRATRTAEDTENFGSRISFISQSMTSLRSTVNDQQKNYALIINGPTLNFATHEDLQRRFLKICLQCQSVVCCRATPIQKSTVVKLVRDNLKKLTLAIGDGANDVSMIQTADIGVGISGQEGMQAVMSSDFAIARFRFLERLLLVHGHWNHDRLSKFAAIMFYKSLLSVLVLFWFQIFSGFSGSLMIDSLYLTMQHVIFTAAPPLTIGIFDKDLSARTLLADPTLYKPGQRGDMYTHWTFLIVMIDSIYQSLCIYFVPHLSYENHAVGLWEFGTTVDVCMILTILLHFCIEINSWVWLQWASLVLSFALFWSFLLISNAIFFTFDHPSNPYWVMENTIATAIHSAIVICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A260</accession>
    <name>A0ABM1A260_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Solute carrier organic anion transporter family member 74D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939306.2">
        <property type="nucleotide sequence ID" value="XM_013083852.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860178"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939306.2"/>
        </source>
    </evidence>
    <sequence length="515" mass="56687" checksum="F3D60FD1E0910C96" modified="2025-10-08" version="1">MSESHDRATQGRNAENGDVTMNNGNADDEDTNPRDVEKASRLEEHPVFVEDNDDNEYDANFFVGGDVIEVSTDDVETRCGVFGCRPDFLQPLAKVGCFAGMYGFSGLVTSTLSVYVNSQVTTLERQFGFNSNQTGLIMAANDVGYLLCVLFVSYLASRLHIPKALGIMTIVFGISGLICCLPHFIFGATLNEGRATSVAPPNMTSSFLEPKGRAQFFGDLCISGNLTEDRCMEKKGSEESDKAAGRGKDDVATISLVIIFIGMMVQGFGKAPRNSYTVTYVDGNTKRTKTGFYMGIIITVGILGPALAFLIGGVFTRIYVTLEATDLHPKHPQWIGAWWLGYIVFGLLAFVVSLPLFCFPRKLPRNKPRIDPMAKPTEKRNKDESNELMMLGTGSNKDPKQHADHPKGPLESIMWYLKDFLSMCLRLWTNPVFVSVSCAACFLLFVVSGSSAYMPKYLETIFDLPAFKANYIMEPPSSVRVIALAKMRVFTLFVETTEGPITPLALPAARSIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A464</accession>
    <name>A0ABM1A464_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101854810</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101854810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940476.2">
        <property type="nucleotide sequence ID" value="XM_013085022.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854810"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012940476.2"/>
        </source>
    </evidence>
    <sequence length="177" mass="20188" checksum="1938461CD47562DF" modified="2025-10-08" version="1">MFTDMQELMTSYKLFHDTLDSFAKQLPSHLTSDAPEGLANNVDVLTNMLTPTDPHFFDGEVKLLQKKFNWVRQVLRAVLCLSFPKVKKESHSWFVAERTKFQTQVDIIKPIMERLTLSGSGVITMPSGIGGNNTGVQQTSYFNPLKLEKLKQALLECLLQIEQEDENSTYTFQCPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6U8</accession>
    <name>A0ABM1A6U8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012726</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941973.1">
        <property type="nucleotide sequence ID" value="XM_013086519.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012726"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012941973.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19198" checksum="95B59AD3461E80C0" modified="2025-10-08" version="1">MKNAEMKCYSDQGLVLHLPDDPNNPDHIKQTSVANALTSTPEVVCKNRAAYDAAIHCSLALSQSCTPKAYQSLLPDENNLKMVQNIMCNNLNSLNHMCTVNNTHDLVDCGIKKYGTMTVADAMDPYKSTCTAYQHAEECLEEEIQECGQANLDLQKQFNQLSAPVACQGAGTAIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A733</accession>
    <name>A0ABM1A733_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC101854996 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101854996 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC101854996</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942127.1">
        <property type="nucleotide sequence ID" value="XM_013086673.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012942131.1">
        <property type="nucleotide sequence ID" value="XM_013086677.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012942134.1">
        <property type="nucleotide sequence ID" value="XM_013086680.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854996"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="410"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012942134.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="52023" checksum="FA4C6A31F0E0CCEC" modified="2025-10-08" version="1">MNQDLCEESTTHVQKLVNVQTTDDSERSTFVGGHDLKDGVGSGSSLAGGAGTTMAGRKATGKRPRSSRAVLKQDVAKGSKNGEKTSILEGMSNVQPVANFIPAWLAQSGLLSLVQTEDTSSSSELSSSAKSSLLVATSSSVDQSSLVETFSSTKPSSSVEKSSSVDPSSFAEILSAKKETRGTQASISPSSGSRKSSLKMSSVARSSSSLPPMPLSGNTKTDILTGITEHAREPASAGESKPSRPSVPAGSSTRPSSQQSVTRMTPRPRSVYTWINPELRQKHYQGSSTSGVVRGTAGQPRHPRPRSVYSWVNPNLRQAQVSAAPGFKSVSQQVSNRSSPPLSCSNTSRFPKTSSPPSLHPDSNSTALGHVGRQEKSTQLQDRQFFAPLPIVTVSRMPPMPKFWEFKPLEFSEVIVVHAESPTSFVAIPAEMKASLGKMEKELEENFLSPQPRVTCLSQETLYAIKKKGVYHRAVFMQRLSQGGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7S1</accession>
    <name>A0ABM1A7S1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101853486 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942483.1">
        <property type="nucleotide sequence ID" value="XM_013087029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853486"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942483.1"/>
        </source>
    </evidence>
    <sequence length="1506" mass="167718" checksum="F2E04DC48E21328E" modified="2025-10-08" version="1">MEIELRSSACHSEGPNRYNTDAGRGLARIEIRSRTKWRLDTGKECLWATFCQVRTSCETSGMTQVPAVSSGFESPHKMMLNPDDPHCSEPATVDRESHISSSPSARRTHAVTDRSPRPAMKELITKFETKSPGASLGLGQASTGGESARVARQAWRADRVSVNLELDPSALTSSSLSEDYNSKSLSTGSKPPYAKSSQATLSLNTEAAAATTATVAATTMAAVNTVVSSPATAKSNVTTQFEQTTGGSGSEASAHNSTPLGETNVQGATMYSPQQPRQVQSTPKILQAGGKLAPETVQLENVLRKDPKVVTGHPPIYPPQSDIGQKSDTQTTDLAEQGAPQRVNLREFAFRGNQGPAKDSRYTVHKKDWGKRFGSRQPITNPIAQLLPRATSTPKPEALTPVFSRIECSKVSRGLRSTEPRRAQSAMSSATSRSLSTGCSLYSLKISPKMDRTQQRSTTSTPSNTQQRLHRRNMTRLTDATKGIDSVSHSKSEERKKTAMERYLQFLKRSTPPLPVPPRDAIRVSTQAPGRALSKEAPSRNPEETASTRGAGNEDFGHRRLNESLEEHLETAQVYREEMFPINLSPRDKHGGGSPSLYHPKLGSPLYMSRGKDTEHGETAGVAADKTLVNSPAEQKTKSPQLCRQGSQCSQILEARLPHRTFQSISGHLGQALQQHQHQPQQEHQHHQQQQESAQNALYQKGRRRSPELFPPQVSNINLPAAGAIDSRPATRRSSPSPIAKDKSQRLRREVSKLSSCQGSPYAGSKGPGAGDSSPIKSKSSEHEMSPLHREISDLANQLLTEDELADNDLMPFHLRDPHRRAVQGKSRGKVTTDSFSSDEDSCTVSIEDRLRKIKARRLLKLMKDAESTKQPGVSYSEALGNAALNQRHHEQGTQRCDQLNLRENVNILSQPRDQSQESHSSSKIRSSLSRQRRPKSEPRPNVYSSGAASSHVHKREKIPLLYLQSPSEHDPSAPGSPKKMALADKQHTPLARIATLQPAFEERWDDDLELREPGEKWEDSRRGVSGHEAFDPSPTQWSVSLTQGKSSPSRGNPAASNIETVTETELAGHTGDNSSRRLREPVQREVSIEDLHNHSEVGYHFGMTKPEEEEKNEVQRAAKDSVVRKKRKAEKIKRVKKRKKKMKVEEADLSQTYRTESRNVTEGRRPPHDGSRTRRHGRQQQHSEHRQELCLPHQELDEAGAFHLPGRHRPQSEERTSFRGNHENNKTIVKMPNARSHSLEIATADKSKHSRQDTPQDITPTKSQRPGSDYFSSHETPGRLSRHPDDNTYTRSPRRLASPVNFTSRWTPRMFLRSVRIRPVRRLSNLPTARWPIYSHIPLIALEWSPPRKRVDTLMCYRRWREDFMDCVRPSRLPLSQAFKKALDSAVMQEWTMHCWEPVSRLADSTGAWVMRADDQEPFYSASDLSLRPMLPLRPRIQDMKLGPLRVSHVMYLLLGAVSLGLGHLAVTLYNCDGTDVEYFCTEDDATCLAQLAPALLAEQEPGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7T2</accession>
    <name>A0ABM1A7T2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="13">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101857136</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_012942497.1">
        <property type="nucleotide sequence ID" value="XM_013087043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857136"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1011"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1062"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1147"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="341"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="658"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="1015"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="1338"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="915"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="940"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012942497.1"/>
        </source>
    </evidence>
    <sequence length="1577" mass="176505" checksum="ACD21B6A46730E1D" modified="2025-10-08" version="1">MANESTPNRWTSFEEFCGYSPFMNKTLLLEDDYPHFTECFKEVGLIWIPCIAFLAGTPFYLVYLLYRKRVRALPAGFLHVSKMVLSFSLLCLSMAVLIVRGTDNKQGDIVDAEYVSEGLRAGCFLTSLCLLRMERLKGVVASYIHWFFWLVSFLATIVPFYSNVKESRDDFDNFGYVTDFIYFVLLLLQLLISSVAEKRPVDYRDLSEEVEYPSPELTASVPSLLTFWWIVPLIFKGFRKTLTDNDVFSLIPDDTSDVVVPKFEAQWKAEVDRVEAHNKKIRPPAHSFYTDMTPNGFGKGSSEKAPLLAKEKPEKEKQPKSPYKTASLGNVFLRTYGTYFLIVMIMKVCSDLLLFATPKVTEALMEHIALKNFNVPSERDWKGYVLAGSFLVIQLVSAVGSNKATLMSRRLGMHIKAAAISAIYKKALTVSSIGAEKSAGEIVNLMAVDTQKYEDLCLYLPMVISTPFQLGLAIYMLYDQLEVAVFAGMGTMLLAVPFNAVVGVFIKKYQELLMAYKDQRMKLLGEVLEGIKVLKLYAWEGSFQKKIEEIREKEVKVLSKFSFMIAVTIFVFTIMPYIIKLVSWGVYIEISDEGYLSPTVAFVSMSLFNMLNQPLTMLPLFFPMFIQAIVATTRISAFLNEEDIKQNVKKDPSAVKAVRISNGNFTWDKSQALPTLRDINVAIKSRGLVAVVGTVGSGKSSLLSAILGEMEKLTGTVIVKSSIAYVPQEAWIQNATVRDNILFGSPLNYRRYDEVIEACALKSDLEILPAGDRTEIGEKGINVSGGQKQRVSLARAVYSDQDIFLLDDPLSAVDSHVGKHIFTNVLSHRGLLKDKTRILVTHGVHWLPLVDQIVVLSDGRVSEVGSYEELLSKDGAFAQFLKEHLQDNMEDSSEGEVDPEVEALKRKVIERLESVSGPVMSGHSSQEDEQTKSFGNSGSLRRRKSQSAPRRRSSVQPKRQRSAVDEILESSLNIPKKDPVAGERLIEEEKGAEGKVKLDIFIHYMKAIGPWTCGIAVFLYACHSGASIFTQIWLTEWTGDDYLANASLSHESYYDEKTNKYLLVYGAGGVGSALFVLGFSVIAAFTMTRAAKRLHMAMLHNIMRAPMAFFDTTPIGRIMNRFSRDSETVDFLLPNTIQNTMEGISQVIVTIVIISYSTPIFLSVLGPLAIIYILVLITYIPTSRQLRRIDSVTRSPVYVHFSETQNGASSIRAYGAQERFIRQSKARVDHNFKFYFAGVGLNTWLSLVLQNLGNVVVFAAAIFAVTNSDIETEIVGMSVTTAMQMTVALQMLVQQLSEAEINIVSVERMREYTYTPREDDWVYPNRRPDPEWPQKGNVEFNEYKTRYRPGLDLVLRDISCQIKGGEKIGIVGRTGAGKSSMTVALFRIIEAAGGKIVIDGLNISDMGLHDLRSRLTILPQEPVLFSGTLRMNLDPIDQHTDAQVWSALEHAHLKIFVEGLQGGLYYECGEGGSNLSVGQRQLVCLARTLLRKTKILVLDEATAAVDFETDELIQKTIRTQFQDSTILTIAHRLNTILDYDRVMVLDRGYIKEFAAPSALLSDPSTIFYGMARDAGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8K7</accession>
    <name>A0ABM1A8K7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012970</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942909.1">
        <property type="nucleotide sequence ID" value="XM_013087455.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012970"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046803484" evidence="2">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942909.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="27669" checksum="4E344B986463CCE8" modified="2025-10-08" version="1">MKVSLKLVVVALVVCACVTESFAQRGRNSDGSGQSGRRRGIRGRQQGRRRNSNRGGSSSAAVEESLPPQPPRESGRRRSGNVLPVPDVGEEAPQEGRGRRRNGRERQEGSNFLRGAVQGLNQGLRRFREWQGTMAETLNGVLTQTFDNIPFEAISDTAFRAAEYFTDVASRRVPRSMFVALLTTTAGGPEDTLAVLRGDAELAQPILNQIAENYRNVVSMAAEEAGTFLDVVLGPGRVAPSTDVMPTETSEENLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA00</accession>
    <name>A0ABM1AA00_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synaptonemal complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943680.1">
        <property type="nucleotide sequence ID" value="XM_013088226.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860693"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008827">
        <property type="entry name" value="SYCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46918">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46918:SF1">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05483">
        <property type="entry name" value="SCP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="558"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="820"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943680.1"/>
        </source>
    </evidence>
    <sequence length="1033" mass="118315" checksum="802C1A7387E5EEB6" modified="2025-10-08" version="1">MASQHTLRFQSNSKVFHQEHLDSKKHAEQGKTCNAYYPGQMNTFSMSQKFTQAYQQQDSEHLTSLHAKLHQEADKIRKWKMQTELDLRDKEKKLNEAYVRIEKMKKSLLELQLDNEKTSAKLQEEITNREEVIRRINSTREMCCLLKSHASKTEERLLKCETEKTELKYVGKENMQHIEDLTFKFKKLQLTAIENEKKMKTKVSVERNDQEQKEKAMKVRMDASEDEIKLLRDEIDQQRIEVANLGSTLQKKENDLQDMGKSVDELQAQVTFLSGQLENKEEELKTSSLHISSLQEESSKMEKAVKKLEQDLTSLQTAKDVMALGMTETKTQLQEQLLKASEEVTTTKEQLEEEKRSLKSCESRLEEMTALIENLKSSRDILILEKTDVEMNLDTQKFHLNCLMAEKQEDKEEMHRLNGEIAILTKKVDRENLLRVQTQDECETLQGKISALELERVEHIDEIASLQVELRAKEEKIKCLESLLSEQESKTINLQSNVENLEQHLTSERDQNTKREEHISVLEEDLQKQEKCVALKDEEIAALKKDISGLYSVKNSMADDLKATVSEVEEYKIKLEEKERQITELTSELEDLSEKGKETGKSMSSQNKKIADMMKQNKALEKEVKTATTKLNKQQKLTEDQAEELENLKQEISSQKELNLEMEERLKTCVQDMQNLKVACERDQKEAKHATEKAVEMQASAQREKENALAMTDCQLTEMMATLDSYKQSSEKVVSEKDVEIQALRLKLESTERASMKLERDIAEYRKEIKLSKDRFEKLEREKDQHIASLQTAAAEKAPYDSAANTHSPTGKVQIPPSTPVVSVAPQQQSVTSVPRTPKTPVNPIPKTPQKSILRVCNSASKKRKVVFQQEESPRGSSSEESDLMELDPEQTVKDKSLTPLLRRASPQISVVKDSVRSYTRSTPSRIPLNQTTRNSAVKKKKEPSELIKNPTTPVVGDRRSYDDVPIERSKQRDDKSSTPNVRKASSKFFTSTRERSGVSTGVSKTKVKDKSGGGGLLSWIDMDEVYGFGPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABM1</accession>
    <name>A0ABM1ABM1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein in mobD 3'region-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_013089138.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47485">
        <property type="entry name" value="THYLAKOID LUMENAL 17.4 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47485:SF1">
        <property type="entry name" value="THYLAKOID LUMENAL 17.4 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944592.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15109" checksum="1752C9BB0AB6270E" modified="2025-10-08" version="1">MSQANMSQASMSQANMSQANMSQASMSQASMSQANMSQANMSQANMSQANMSQANMSQANMSQANMSQASMSQASMSQANMSQANMSQANMSQANMSQANMSQANMSQANICVFGRVIEHPADNSPWGTQRVKFFIHPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABM8</accession>
    <name>A0ABM1ABM8_APLCA</name>
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        <submittedName>
            <fullName evidence="4">Serine/arginine repetitive matrix protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858975</name>
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    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944614.1">
        <property type="nucleotide sequence ID" value="XM_013089160.2"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Mif2/CENP-C_cupin"/>
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    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
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        <property type="entry name" value="CENP-C_C"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1655"/>
            <end position="1731"/>
        </location>
    </feature>
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            <begin position="84"/>
            <end position="507"/>
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            <begin position="519"/>
            <end position="729"/>
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            <begin position="815"/>
            <end position="862"/>
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            <begin position="876"/>
            <end position="1411"/>
        </location>
    </feature>
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            <begin position="1424"/>
            <end position="1445"/>
        </location>
    </feature>
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            <begin position="1458"/>
            <end position="1501"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
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            <begin position="351"/>
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    </feature>
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            <begin position="381"/>
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            <begin position="421"/>
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            <begin position="458"/>
            <end position="481"/>
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    </feature>
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    </feature>
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            <begin position="915"/>
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    </feature>
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        <location>
            <begin position="976"/>
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        </location>
    </feature>
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        <location>
            <begin position="1000"/>
            <end position="1010"/>
        </location>
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            <begin position="1012"/>
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        <location>
            <begin position="1097"/>
            <end position="1109"/>
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            <begin position="1148"/>
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            <begin position="1203"/>
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            <begin position="1329"/>
            <end position="1338"/>
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            <begin position="1340"/>
            <end position="1350"/>
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            <begin position="1385"/>
            <end position="1402"/>
        </location>
    </feature>
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            <begin position="1436"/>
            <end position="1445"/>
        </location>
    </feature>
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        <location>
            <begin position="1458"/>
            <end position="1473"/>
        </location>
    </feature>
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        <location>
            <begin position="1474"/>
            <end position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944614.1"/>
        </source>
    </evidence>
    <sequence length="1747" mass="190237" checksum="2BD0C616523D992C" modified="2025-10-08" version="1">MDAEEVYVYNPFQGIEIGRRTGISIHKVKNVKNGMDNIDDYFTDSEADQTLDVTQQVPLTSVENTKVSPHKNVKDVVLAPAQTGTTKRGGAVKNVKQPTTARKSEGAPSKSPAMEVPVNPFDWNPRVGRRTGRDLLAGKNVSRVENFSQLQSDNESTMSPQLTPETSSIKNSLRSGSPGETNQPNASTLHNSGSVHHSDSLSSKVHRRMEERASSNSGKTSSAKKKVLDSGSGELASSGSDTETRKEVKATTGRRKSMRKNHALPASHDDEEGKSSPADSQEDKDQGSHVDRRRSVRKNQALSVSHDDEEGKSSATDSQEDTDQGSHVDRRRSRRKNQALSVSHDDEEGKSSATDSQGDTDQGSHVDRKRSRRKNQVSPVSHDDQGGKNSPHVDQDPNQGGGHGGKLDSSRKQSKITNDVGQKRTELDKRPHSEHLGTEQTEDLNLSRKGTLRKGLKKLQEKSPSEERKTGSSSDSSEKLSKSANVSLKQLKESSGRDSSACGADPPLEQAVAELSKNLNKSQNEGVRKSLKKVKIIAAGDNVETILHLSRIKPSPQKRTGNNSDRDDDTEHGATASAETEPPESKDGSTSGDSSTLFKRPPSSGGEESEGLTENGGKTKSSRGASKVRGLNTSSKVNVSLKSKPSAVGESEVVMKREKSVQSASQSGRKTDGSGKDQMSSREDGSTAVSQEISGLGGSLLSRPGRSLLDKSKDTTTTATLNFGGDVTGSVTNAEKASASHFFGIKKRLSYSVAIADASKNKTDRSQNDIEKKKSAIPVRTRANLSQSQQDKTLLSTFESFTFVDVGGQDNFVIVEAGDEEERNDATERSKTKETRKRKSSSNTLDQGASSPSPPKLSKTDLLALGYSAEKIATLAADEESAKGKRKGKGKAVQTRSAAKNDGQKEKDMVVISAGQDSESVRSEPNTDISPKRSGGRAKLKDKKPSQTKPSQTDRKSSESSDESAELPADLDTRKKATKRSSRKRKQEAEENVPSTRAASKREKDSREVSEVTLSSSKMLTLSRTVTSKDISSRGRVRKKAASKEYPFSKTSGPSKEEETDDEIILGGFKKGSGLEKENSIKRKRVQSQPKLTRAVSKSKKVRQSKRRQAAPLNKQLRKRKRNVDANTSAGPEEQECLQTNVAGEISEVCEEAEVSLAEDEKSPVKPPQSDTKSCDPPAEVQDEEKVPGNPTTGSRTRTKSSTTKEVEGSRTKAKPSTKELGGRSAKTKSSSTKELESSCSRSKSCTKKELERQVGTSGPRRSLAAVLEDSVSASDDGDKEKEVEEENAQDLAGEGAESTEGEAERLLGVSETKPEKSKRLSTSKRGKKEKEVTDQPRKSLSRKPRHSQKHVPASATPQRVNLLLSLPSVTPQSGPSFRLSRRFSPQLSSPDLDSSPESPSPRVETPGPLARNTKMAIPAVDATPQAPASCLRGNNPHKRSLKGRKVRISNIIDRLEVSQNESNEGELSSDGRSSTMLPSPTSSPVHYAETTHHYPSPKDFLVPDLSNKIIRPGSENDDGLRRSHRTRVRRLSAHKGEGIIYRRDSTGFGMMVAGIQPSVVEAKERAREDKRRKQIKQRKMKALSVPAHGPKKRLSCHYKTDKDVTLTTEVAVLDPDTEEQKMMDLVARKDQREWYDSDLAPLTGSGPIAFGLQLQQANFFTGELQLGPLAEKIYSRVVQTVVFHIVHGKFCLTVNDVSTVVETDDDFFVPRGSNYSIKNLRRDVGRIHFINFNEIVGDTDADEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC97</accession>
    <name>A0ABM1AC97_APLCA</name>
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        <submittedName>
            <fullName evidence="9">Transcription factor 12</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">LOC101848788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
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            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_013089499.2"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18945">
        <property type="entry name" value="bHLH_E-protein_TCF4_E2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051098">
        <property type="entry name" value="NeuroDiff_E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793:SF13">
        <property type="entry name" value="PROTEIN DAUGHTERLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="592"/>
            <end position="645"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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            <begin position="49"/>
            <end position="97"/>
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            <begin position="119"/>
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            <begin position="475"/>
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        </location>
    </feature>
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        <location>
            <begin position="663"/>
            <end position="706"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
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        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
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        <location>
            <begin position="285"/>
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        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="321"/>
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        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="491"/>
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        </location>
    </feature>
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        <location>
            <begin position="522"/>
            <end position="540"/>
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    </feature>
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        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
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        <location>
            <begin position="585"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="673"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012944953.1"/>
        </source>
    </evidence>
    <sequence length="706" mass="75145" checksum="2413957719F0E57D" modified="2025-10-08" version="1">MQNQGQHPGVAQHWNQIPERGGNAVSFGDRMNVADKELNDLLDFSAMYSPPVPGSGGPVKNGPSEPAGMYPHGYKPSGMPEGGSWSNNQPSSFENRYEEHRAQYNGNGGPEHMDHFLGAGPNEDKSELYPRPGYAGRDGLPPQGMMGGSMSLDAMVGGKTTCPAYFPPYKRPLDESPRGGRSNDKFAEASKRRKTGAVYSPGPEEFPQDSPRYNSPKPGMYSEYFMDHPPGSNEQWAGPPGSLPSSYPSSHLPGSSSAFSQSSYSSMPHPHSDMPYHHSPSQQELLSSSGLPPMSSFRGGQPGPANVPSSASAPAYSAPSPTVNGSDMMVTRPSVSATQTGIAVGKALQSIYSTEQTSSSYGGSNPSTPVSSPPPMTGGSQSQQWNRSASGQPANSAAYEGSHLHSLSRMEERLDLDDAIHVLRTHAEGQPLLPQGHPGLPPAALMGAGHPGAAPGMAAAMGAYPPGMMVGPPLDAASHMPGHHGMSDRVSAPSSLQPQSSDPPKPTFDPGDDPDDSSEGPIKIEKSDKGDNDKGDKSGLEKSSQSSSQGGEPPVKRSRPHPKASSSNDDRASLPDDDPNLSVADKAERERLRRQANNNRERVRVRDINEAFKELGQMVTLHCNSSQPLTKLMVLQQAVNVITSLEGQVRERNLNPKAACLKRREEEKTEELPGRASLSGEDMSQQPGLPNKCPPSEPGKGPWPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD96</accession>
    <name>A0ABM1AD96_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC106013676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106013676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945488.1">
        <property type="nucleotide sequence ID" value="XM_013090034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013676"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012945488.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43322" checksum="2E3B8F1DEE422EBF" modified="2025-10-08" version="1">MNLTTVFPPAHNVMSRDPVSDELRASMTIAFSLCLHTSIITTGCVTNVINAIIFLRLGLSDSISVSFFFLAISDFVILFQNLLARVFGILDSYLGVNFGMLDIRSLGFLLTTFASVPYDITVCITLYTAVQKCCCVVFPFRFNRVFTRSRSIFINIFIYLVVVCYHIPAIASQHLRLVRNPSSNSTKLSVWFSPDRNRNVAALGLLRNVVITTAEIVVSFCVIVFAYKLKASSQFHSIRAKGEFPSQKEEGTVDPEIEENGKTRGNETDTKRKNKTGQNGHQTSSGEGRVGSSRKNQTSKEVRATQAVTMVSTLFVSCTLTSVVIIYVSLLYPAFSPRGELVNLYYVTVQVRLTLIFAWLSLNIVVYCAYNTRFRNELFKIFCPKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADB4</accession>
    <name>A0ABM1ADB4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA dimethylallyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101864432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945509.2">
        <property type="nucleotide sequence ID" value="XM_013090055.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864432"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012945509.2"/>
        </source>
    </evidence>
    <sequence length="121" mass="13603" checksum="27A9292295048C50" modified="2025-10-08" version="1">MAATRLPLVVVLGATGAGKSKLALEIAKLFNGEIISADSMQIYKGLDIITNKVTEEEQRECKHHMISYLDADYKHYTVVDFRNAAQPIIEDLLSQRKLPVIVGGTNYYIESLLWDFTIDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADG3</accession>
    <name>A0ABM1ADG3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101854611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945584.1">
        <property type="nucleotide sequence ID" value="XM_013090130.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854611"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF232">
        <property type="entry name" value="LAMININ SUBUNIT GAMMA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045034944" description="Delta-like protein" evidence="10">
        <location>
            <begin position="30"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="12">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="298"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="467"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="566"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012945584.1"/>
        </source>
    </evidence>
    <sequence length="693" mass="77998" checksum="F4D4BD11A6387288" modified="2025-10-08" version="1">MSGFDEGWRRRRWIRLIVFFAVLAKVADAKGVVEIHFLRYTDRCEDNFGFTDCDPKFTFCLSRPVNAPTLTGCWYGWQGESGHYHDENDIDFSTQTDIKGIPNPWVIPINALERSMSLSAKVVDDEVFFDEDLEFWHTTFSLTTSKSVNEAPWKRVTMTKNDHTLKFRARQYCEENYYTSSCTKYCKPRDDSGGHYRCEDGTGKHICLPGWKGPPACTTDVDECTEVEDSCVRGTCENLDGGYKCNCPEHYFGTRCEGVEDACEPDPCNQGICFVHRTDYGFHCACANGWEGKTCEKREDPCQSSPCHNYGACLSNNQRTSFSCSCFYPYTGTLCETDASTTTSTTTTTSTTPTTTTTTPTTTTSTTPIGSGSNEGLEQQQIKKKEKHEFKMWYLGIIGAGLLLVLLLLLLLFVRRRRKKAHDFPMQNAVVVFSNDEMAFDNALYIEANESNIEAERQARTLPAVPTENDDIVKPSFENVDESQGAVGGKIAPDEKKTSPSATELKRASGREKAEENPYSDFERLRNESQRQREAIYDNNEEDDYQDLDEMAINLQFVSDGSPYDNSLHVDLSSAQTDEVSSSDPDAQTNPGVNEDTPPQQLSDPDEIVPPPRSQRILQSSLIIDQVTTSSTSMNGEENVSIRGEETRQENDEDEDVELSSDDDQEDIAHLKRSVRASQKHLHMENPTFQNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADJ2</accession>
    <name>A0ABM1ADJ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106010996</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106010996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945627.1">
        <property type="nucleotide sequence ID" value="XM_013090173.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106010996"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="128"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945627.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33574" checksum="8F69101160139EBE" modified="2025-10-08" version="1">MATFPRRTKKCILICCLFGAITMIDLVGANSNLDTKTQALEEFKVSSNDELMRKSNATRTLLNEEGRQSSQHTDGSEKQAGVRDNLFKQHTRPRYPARGPGQVWDDVMMGFQTSMLEKTSDVTAPGDQEQCQEDLSRVFLSAVSQAPWALQFLDSWGKPGAGLFKYKPAFYGDFDTCIGLEPPENFTTQYCTVSVSAKRLSFFMRYIVSDWEDCCDGLIVLSVFAGLMALGTIYDVMVVRGYFRELTGSDGLSSNNARLSEQISGSYTDSTIRYNAKGEYQPLLDSTQKSMEIVVDYKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADM1</accession>
    <name>A0ABM1ADM1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 7">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101848860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPK1 type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 7"/>
    <dbReference type="RefSeq" id="XP_012945660.1">
        <property type="nucleotide sequence ID" value="XM_013090206.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848860"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012945660.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="44428" checksum="73259AC023E42748" modified="2025-10-08" version="1">MDSMREFANLEYRGEGNCAIVLASKKTKQVYRLVKCKATQKIKKKLERNSDCGLSNSDAKSIQSAIRAELDDVISYMNNVIKPLMSEQYVVTPSVTTIPKSFGEKSVALVSDARPAHRRKSQCDIVDPDVRSALVLPDFCFVYHPKTQTSTTEPILEQFSDLSHRGIQSGHVCLTITDRSASEHGSCCSSESDSFGSSHTDLSCSSQRKDSLEEEDDDAGDEVDGDLCVRNQDGHFNDVSDSQQCVHKAHNGGGGYVQPYICNKASPFSPNGYRKGVGTDCCVMQDRRVGGEGFISDFLRSPSMPSQNDQGVNDSQFTISIEIKPKKGFILRHPHGESSGGMEQVCRFCMHQILKRKSGQWPQTSSYCPLDLFSGNRQRMKHALFSLIKTPQNNLKICRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADQ9</accession>
    <name>A0ABM1ADQ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 13A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106013736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945731.1">
        <property type="nucleotide sequence ID" value="XM_013090277.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013736"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012945731.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32458" checksum="96D9A7986E764F7C" modified="2025-10-08" version="1">MVFESIVVELINRYLGEFVENLDTSQLKIGIWGGDVVLNNLNLKESALDELDLPVKIKAGHIGKLTLKIPWKNLYTAPVVAEIDGIYALAVPNIAIKYDEAKNQKAAQDEKQAKLQKIEDIKKMEAEKDKPKDPKQDTFVEKLATQVIKNLQIRVSKIHVRYEDKYTNPDRPVGIGVTLQELLFQTTDENWKETVIKEAVTQIYKLIRLDSLSVYWNSKAAMIQDKDKETILVCTYALLPSPHFLLRPICYFVLACAHTLAYAYTDAHLHTDKQKHVHIDNCVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADV0</accession>
    <name>A0ABM1ADV0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protogenin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945800.1">
        <property type="nucleotide sequence ID" value="XM_013090346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862316"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="37"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="147"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945800.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24209" checksum="0804910C7EAE5167" modified="2025-10-08" version="1">MASELLYLGILFTITFNCIYGQGFSRTKGNGVDKIKPGVALVPAAYKVYLQRRTPVLLNCSLNVTDPSLRPLSYTWFKDGEEVDVDRPKSKIQLFQNGSLYLGPGFRRRNRGRNSRKMDGLYVCKVKTTKGILIARRVHVVMSVMARNFSQEPASREAYQGGVARFTCDIKAEPPTSYEWFKDKKQLSSERFHTLSSGILQISDVQDSDTGFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VP22</accession>
    <name>A0ABM1VP22_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Collagen alpha-1(I) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824164.1">
        <property type="nucleotide sequence ID" value="XM_035968271.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860554"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046175336" evidence="6">
        <location>
            <begin position="38"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="7">
        <location>
            <begin position="1478"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="832"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="866"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="920"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="969"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1162"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1207"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1252"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1334"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1358"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1415"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1428"/>
            <end position="1440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035824164.1"/>
        </source>
    </evidence>
    <sequence length="1700" mass="170551" checksum="08E7BDD3B8A36B13" modified="2025-10-08" version="1">MLMPSPRRMGKSFSATDLLNVLPLALIILASVPFSLAANAPLPPDSVDVLEVFDFDSVSQAQGVVKVDGFCQDRVVSDDPDDTAVVADPAWRIKNGEFLQHKGIKEVFPDGIPEDFSVIITMRPDEGVEGKVFSIYSDRTAHEIMSLSVGSSPQFLYRDTNNQPGPETSPRFDIPLNDGFWHRVALSVKGKSVTLIHNCQQQATYTLNRTLPADMDRKGMMFVGFHINGEESDVFTGDIQDLLFIPDPGAAYMHCETYAPDCDIPLPYMMSHSSSSSSSSSSSSSSSSSSSSWSSEVGFSNSSGSSVTLEYGSVEMTDVTYRFGPPGPPGQRGPPGPPGLKGETGLEGREGIPGANGVPGPPGHVFVFPMNWDNKQNNYADQFRSMLDSHMLAMRGSPGPQGMTGLSGRVGPPGPLGEKGDIGNNGEMGPMGPMGMPGLSGPLGKRGRPGKDGDRGMMGPQGDKGLPGFPGIPGMPGEKGHRGIPGAPGEAGPVGPEGDQGDPGEIGPMGISGEMGPRGFIGPRGRPGPIGPPGLPGGEGPVGPKGNQGTVGAPGAPGQTGPAGQTGPPGSSGPLGPGGIPGATGKPGLPGLPGPMGPVGNSGSPGEAGPKGDTGPRGVQGTIGYPGPRGVKGDSGQRGGAGEKGDRGGAGLEGVPGELGQKGEKGLRGLRGLPGPEGIEGPKGEYGTAGETGPTGSQGEKGRIGIPGFPGYPGGPGSKGDQGRTGRRGRRGLRGKTGLIGPQGEQGEPGLRGQRGERGKQGIPGPPGPKGDLGVPGPPGFTGEQGIQGPPGPPGLMGPPGPSGVAGQDGQTGVPGDRGEPGIPGSPGQPGPVGVMGPAGPNGESGPPGERGPPGNSGPPGDTGIPGASGKTGAPGAAGPAGNPGPPGPTGPPGFIGDRGYPGSTGKEGDPGSPGPEGPLGPMGDKGAVGPAGPAGPIGMAGPVGTPGSQGKRGEKGNSGPEGPRGLPGPLGGPGPRGYRGPSGPVGPPGMNGDKGDSGPPGERGVKGSYGAQGPPGPQGPIGLQGPPGPPGAPGEKGPRGLQGPLGSKGSEGPRGLIGPAGLPGLQGLPGPPGSKGDSGEAGKLGPPGSPGPQGNPGTPGAAGSQGDVGGPGALGPPGPKGDSGAPGPPGTPGIDGPLGSPGLQGAKGDEGRPGLQGDPGPRGERGEDGIKGHMGMMGPPGPAGEAGEVGSKGESGPPGKDGDTGIMGPEGPVGPPGEAGLPGIPGKQGEMGIPGLPGSDGVTGPKGDRGFPGNRGQRGQPGPAGVTGPQGLIGPPGQPGPVGETGVPGPPGTPGGQGPVGPPGPIGTKGNRGPKGVKGHRGSIGNTGPEGPPGLKGEPGPRGFEGPKGGPGPIGPPGSRGSPGLDGPTGNMGPQGPIGPKGENGMTGPKGEQGPPGSAGPPGPPGEVLGVQPRTISQARPQNDSARRRRRRRRRRRRRSVEPADIDDDLDSVRSKLLAKQENGIEVQVGEVIQEVSTVMLNHIDALKKEVDNIRYPEGKRENPAISCREIKLGHPSYKTGWYWVDPNLGSIDDAIQVWCNMTETPETCVYPTQRTKMSRERFYEKGKKFKMFKQLKDGFQIQYASSIQMDFLRLLSEKATQRFTYYCTGSVGWYDTKADGFENAVSLIGSNDYEYETAKFHERQVVHDGCKDREQSSFTAFEITTKKIQRLPIVNFRPRDYGEPWQKFGFEAGPVCFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ33</accession>
    <name>A0ABM1VQ33_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Protein enabled homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101853686</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824523.1">
        <property type="nucleotide sequence ID" value="XM_035968630.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824525.1">
        <property type="nucleotide sequence ID" value="XM_035968632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853686"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035824525.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24467" checksum="656BE4691C0D2C50" modified="2025-10-08" version="1">MDDLIIVYILTAFCTLLAIASAVLIYRNVQWERSEVNRHRLRKEKMRSKPRAVFTSSQRPRPNPVLTMPTKCASTQTDDIDLCLPETPDVAQQEVFLRERTSRYDDNSDVTTAAAVTVDSVGVMDSSSSKEEGLSRKKPDFEEYRTQKMGHPASPLKPFHPPTSAAPPPPPPPLPPPPPPPPPPPVYSFPSEDVQAITEKLNDRTRLFPRNGLPEGLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRV3</accession>
    <name>A0ABM1VRV3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Arginine-glutamic acid dipeptide repeats protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101847101</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005096569.1">
        <property type="nucleotide sequence ID" value="XM_005096512.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825145.1">
        <property type="nucleotide sequence ID" value="XM_035969252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847101"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040169">
        <property type="entry name" value="SUGP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340">
        <property type="entry name" value="ARGININE/SERINE RICH SPLICING FACTOR SF4/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340:SF0">
        <property type="entry name" value="SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="6">
        <location>
            <begin position="655"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="712"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005096569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035825145.1"/>
        </source>
    </evidence>
    <sequence length="1074" mass="116037" checksum="8A20CB282FBE839D" modified="2025-10-08" version="1">MSNRKKDRNQGKVLDLSEHEKFLEERVKQYKEKLEAQAKSATVNKAPSASDVNTARLIGKSTKTTTTPAVNNLFSNDGSFLDQFRKLTGQDKTSVAKKSSASSESKALLQNKVKSEPSSSKLDSNKYKLPTPSIILPSFISKGYGQNDVKEEVKQEASEDSSKSPEDFASYSPEEEENGQEGEIASPADSPGQQTQEESQNGHAQNDVSTDQTQAAPAPEVAVLSTEHSHNYQSYEYSQAVTQAVSDPEMVSQVAFSTYTTHGQCLATSSQPSQPVPSFGPSYAPQYSQAPPLLSQPLLTASQPQAVQMSLTLSQQVPPVDPNLYSVANPILQPSLSVAQGTAPAMAAPGMVLVNAQNVASPPVINLHHSVAPPGSMPSHMAPLPVATSGMAAIQSPLPQIQTVIVSSVPLQIPPSVAVVTSFNNGVQSVAPTQHIQAVQPAQPTAVSSMYLVPMQPQNPPVMTNVYTPPPPMSAGSLPVVNSVTPTAHFSTGYPPPSVAPSSIVPTLAAQPQPASVAYNPHVNAGMGMYGPTPVQQQPIVTLTQSQPAAYVPYVQPDLSKPVIKQEMGMYGPITTAVKSEVEEYDPAAPTDDTDVSDHVMPGVTMVSRCNGVSFSLGQKNVAKNDGTRLPGAFMSELDNGPPVCPPEDKETLDVIEQLAAQILLSGPETEQKALDEHANDPLYWFLRNRASDTYKYFRWKVEQVLRLNVKQEADDADAEDDGERDLRQPMRKKRRSRWGDQKAPIAQPGVAAPSLAPPGVVMTPSIAPPGVANPVLGPPGLITPSLAPPGVATPSLAPPGLVVPSLGPPGIAAVGGTVPGVATNIQLGGVTTIQPHMQLPPRAQIPVPNSSNMQDYARKMIGSDSISEEQLKQIREQQELNFMYELVVAQKKIQEQAIMAEIEGIKVKRKYEYDSDEDTEGGTWEHKQRAKEMTATKEWAEKLTSGSRGKHFIGDFLPPAELEKFLETFKALKEGREPDYSEYKEFKLTCENMGYQMLLKLGWKEGGGLGAKEQGITKPVNRGNTTVEGRGLGIDRPAELTKEDDEYDAYRKRMMLAYRFRPNPLNNPRRPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT50</accession>
    <name>A0ABM1VT50_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101854637</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825592.1">
        <property type="nucleotide sequence ID" value="XM_035969699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854637"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="64"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="217"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="416"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035825592.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="64643" checksum="7715FEF99E4E8406" modified="2025-10-08" version="1">MTMEDDSTKNSRSCECTSLQHSVCLESMVITLTIVSALAVTGEMLLDFHFFTVTETISQDNQSLAGEAPFQEDKDVMDILDTVFHYTSLCIAGLFGLEILLKIAFLRMRFLRHPWQILDIFVVSGTLGVEIAFHFLDLPYDSLYAVSYVVLLRLWRVPFVCNIRANLIREELEEDMELYRCGRQKAEERCSWLEENLNQQANIIKGLEQTLLGLKPSSMEDEESSHAETQDNSQPSAAGSHVTTNYGQNGPMMSEQPSVQSSRKDQNQKKRLHRSKKRVESDNAEMEMSEFHKDNSRPDHAGKRENIESSNFSESGTKRELKDKGDNSKAEHIDTSEVQLRPRGYSDNMLDFSNTNSLPRSEASLNSSSSTPRPGQINMRQRKRRSSTSEYIDYSNLSSPEQDKVFYDDVKDKFSSCPSLDHSTQSGEKERSVKSPELWTGKKKEVIEGGADEVDGGTKEDADNGSIKKTDSSTSDASSGVSSEVSVNGKRERRDRKKYKRFTSCPEYVITQRMSITNDESKLLDESHTTEDPSMYDNMAFLNDEDTGLHVLAEFDGSKTYRNEDGIPMTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTU3</accession>
    <name>A0ABM1VTU3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011839</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825835.1">
        <property type="nucleotide sequence ID" value="XM_035969942.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011839"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825835.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38198" checksum="D88C3CC9BA49F867" modified="2025-10-08" version="1">MQANHHSVSLSLKISGASASDLFALRDKRGAKDFIAAIDSRIEEFHPSVSHYKREHAPNRRYLSSDITIREMHSYFTETYCSLKAGYKSYPCRKTFADTLTKCYRDQNFGRGLVFLNVTERRDAILGVNKTEVERFCQVKNTIIQCLKLSAVQCNDSPIMLRKFSLDIERLNSTYTVLCNHTDVYEDAVKCFRQPTREVSACRQTVVSKVMSLEGQLADLNVTEAQFRDDICRIRVDQIQCETNAIIAENDTSKCHDVVLGMRRQQECTLLPKECRNSDLGRISRLCRVSDFYIPDRAFYKSLAPPFFKSSQNKWNLFVAVFVVVLTANLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUH6</accession>
    <name>A0ABM1VUH6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101853623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035826068.1">
        <property type="nucleotide sequence ID" value="XM_035970175.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853623"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="31"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035826068.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45521" checksum="5C137BACB73B2A30" modified="2025-10-08" version="1">MADSVFKNVEMAPPIQVFQLTKMYNECSNENKVNLGVGAYRTDEGKPWVLPVVREAESQMAADLTLNHEYLPVAGMPDFRTSATKILLGTNHAAISENRTESFQALGGTGALRLAAAFLGNVLGFKVVYVSNPTWGNHKGIFKSAGFSIKEYRYWDNANRSLDFSGMMEDLSNAPENAVVILHGVAHNPTGVDPTPDQWKTICQTCIDKKLFVLIDCAYQGFASGDLDQDAFASRYFADQRMDMFVAQSFSKNFGLYNERTGNLVVVTKDASKLPEIRSQMEIQIRVIWSNPPNHGARIVATVLNNKAYYEQWKGDILTMANRIKKMRQELYDALRDMSTPGNWSHITKQIGMFSYTGLSEEQVELMKTKYNIYLLSSGRISMCGITSKNVAYVAKAIDAAVRAYPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVQ0</accession>
    <name>A0ABM1VVQ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101855877</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101855877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826492.1">
        <property type="nucleotide sequence ID" value="XM_035970599.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855877"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="291"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035826492.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="52193" checksum="BA9F669002EF6883" modified="2025-10-08" version="1">MVVLGGILMHLTLGTLYTFGNLSPYLTSFMREYGSAPSLTHTQCAWIFALASMGQGTSFGCISNLRDGKGVVRTDGPHIRPHVWIRYWPGLHSTAGVCNEEMAFHRKLHLPRRLTANEDNNFKVKWFPQRKGLVNGLVVAGFGGGAFIFDQVQTAFINPDNLKPLKEVGGDKHFDQASVLDRVPTVFLILGGCYSGMQLLAAPLMCNPPGYSSTQPQPEKKEPVNQGGGATRRDDDLHPPSPLLDQPNKDGREGSSSSVPATTADKADEQPCVEDTDDYTVSPRQVLKSRHFYCLWAMFFLNGMGTTFISTLYKAYGQTFIKDDTFLALVGSFAAVFNGAGRIFWGTIADKFSCRVALLCMSAAFCSLMLTMSVTSYGGKPLFFIYVCLLFGSFSGSYVLFPTATAKCFGRKSLGVNYGLVFTSQILIAPLGVFLSETLKTLIGWNGLFFFVAAFSLTSFLLAMFAFTAKDKNGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW26</accession>
    <name>A0ABM1VW26_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface glycoprotein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826618.1">
        <property type="nucleotide sequence ID" value="XM_035970725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477954"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826618.1"/>
        </source>
    </evidence>
    <sequence length="1025" mass="117330" checksum="B9D6FE525C0F4FE9" modified="2025-10-08" version="1">MEEEQPSRESQLIQGESSPTSRQSGSPRTPISRASSNSNRFQPREVGEEESQREEPDQPVQELIGEPVYKELDEPVVEIAEEPQHEESIYREAELESVPRTPSSRKSPSPSRTPSPRKQSQPSRESQLIQGESSPKSRQSGSPRTPISRASSNSSRFQPKEVGEEESQREEPDQPVQELIGEPVYKELDEPGVEIAEEPQHEEPEREESIYRDAELESVPRTPSSRKSPSPSRTPSPRKQSQPSRESQLIQGENPPKSWKSGSPRTPISRASSNSSRFQPKEVGEEESQPEEPDQPWQEPIGEPVYKELDEPVVEIAEEPQHEEPEHEESIYREAELESVQRTPSSRKSPSPSRTPSPRKQSQPSRESQLVQGESSPKSRQSGSPRTPVSRASSNSSRFQRREVGEEKSQPGEPDQNNYQNDGPYQSYDWQEHYQDWDPQLQEGDPSEEPVQELIGKPEYKELDEPVVEIAEEPQHEEPEHEESIYRDAELGSVQRTPSSRKSPSPSRTPSPRKQSQPSRESQLVQGESSPKSRQSGSPRTPVSHASSNSSRFQRREVGEEESQPGEPDQNNYQNDGPYPGYEWQEHYQEWDPQLQEGDPSEEPVQELIGEPVHEERDEPVVEIAEEPEHEELEYQEPEYQEPEYQEPVYREAELESVPRTPSSRKSPSPSRTPSPRKQSQPSRESRLIQGESSPKSRQSGSPRTPISRASSNSSRFQRREVGEEESQPGEPDQNNYQNEGPYPSYEWQEHYQEWDPHLQEVDPDEEPVQELVEDPALQEPRERVIEIEYEPEDEEPEDELPEDEHLDVYDQEEPDQGEQNYDDEEEPVWGRETELEPDLRTPSSRKTPSPSRTSSPRKQTRSPLRTPTSTSTGAERAPSGERYYTSPRGSEGRSSKNQSTQLSPQASVATQTAFMSPRPRSRQEEMWEEEEDYPEEVYDEDIAYSKRERREERGEREEREEREEREEDARNNNAGDQPSGVIVYQMSIRFACTNGIRVSGGVRVLLDINNRMGYVQVISLLNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWD2</accession>
    <name>A0ABM1VWD2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826724.1">
        <property type="nucleotide sequence ID" value="XM_035970831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860181"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="14"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826724.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34992" checksum="796565BDD53B08A5" modified="2025-10-08" version="1">MNVSADWDKDRCFRLLEEYENYTELWDTRNDLYYSKSRKNDCWEAISVTMNCHVDEAKRKMESLLASFRREKSKAKKIIALGLERGTHEVYESKWFAFDKMSFLMDRSRERDEVLVSTSSNFIISNARKPPKPKSTETLTFQEPQCEIVKQEIEIIEDDPPDLPPSDIEYNEEVSDEIEDEIPEMSPASPAPSISPPASISYNKPDAKTPTSSPIAKRRPIKRKANDRDIFSRLANQLRRSDGSNNSRCDEEDDNFDIFGKNVAAKLRSMSREQRIFAEKVINESLYYGELDCLTQLSRVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWM5</accession>
    <name>A0ABM1VWM5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter F family member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826817.1">
        <property type="nucleotide sequence ID" value="XM_035970924.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478031"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826817.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="52549" checksum="5004CB4FDBA6AD20" modified="2025-10-08" version="1">MSVEHSGVYMPRNNPALGSFFRGPKGLEYLKEFPESPRSAPASRTPPNSARRRPLTAPPPERRPLPTTSRPLWPEKKKGRRPHPHSAENIKRKQTKLNVVGSRLPIGLGKDLDMRIARMQRQDSAHQMRGAAEDEIYVVNQPPPTPNSLAPIKDEATEMKEEEEEKQEEEEKPEEVEEEKVVETVGEKEKDKTELGEEVRGEDVPKETVGAKEGDEGGEEEEEEEEEEEKEMSLPRVVVDVRGTDERGDNELENTEECKETKKGTERGEESPDTEPAAGGEGRNEEEKTEEEEETGVIVDEADHAEEELPREGEESEQAAGETGEDNTEVKVERTKSPTAGMSEAPNEAKAAEEIGLLQGETSGEGVVGDAGETEREDGNVKTDDEEVNENVEKDETQEEEEVGAKDSVVEETPEMNNSEEEEEEEEEEEEGCKSSKEVRFFITEEAAIVKGGDNEDEEEVKEQEEEAENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W022</accession>
    <name>A0ABM1W022_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine protease 42-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118478469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828015.1">
        <property type="nucleotide sequence ID" value="XM_035972122.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478469"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828015.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25986" checksum="3D6EFA67F9668492" modified="2025-10-08" version="1">MLHTEEPSSIADAGNTVYDAPSRILVVAGEYNVSGIDRNPVTGQPQEQLLNVQSVYFYPTYPFKTQEQMIAKIQDTRAINNDGVALIKLRQPINGQCSALACLPTEFEVGNACAHYEECVITGWGFSTENFSDVQDELLLSRVRLSSSEACDFLTKRLGLSDFRPRGSACQSPRNQNTDSCLGDEGGPVLCAWGNHWVVRGILPFNLCASGRFNLYVTEIAPYLSWIKRTMTSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W036</accession>
    <name>A0ABM1W036_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478472</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828029.1">
        <property type="nucleotide sequence ID" value="XM_035972136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478472"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828029.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25762" checksum="9A6509F94F350D49" modified="2025-10-08" version="1">MCGHLFMWSVVISSCGHLHVVISSCGHLFMWSSRVVISSCGHLVWSSLHVVISSCGHLFMWSVVISSCGHLFMWSSLHVVCGHLFMWSSLHVVISSCGLWSSLHVVISCGHLFMWSSRVVISSCGHLFMWSSRVVISCGHLFMWSCRVVISCGHLFMWSCRVVISCGHLHVVMSCGHLMWSSLHVVISSCGHLVWSSLHVVIFSYGHLFMWSSPDSAILTVYSSVQIRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0J1</accession>
    <name>A0ABM1W0J1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101853967</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 11"/>
    <dbReference type="RefSeq" id="XP_035828184.1">
        <property type="nucleotide sequence ID" value="XM_035972291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853967"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01570">
        <property type="entry name" value="NAPRTase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="28"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="447"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035828184.1"/>
        </source>
    </evidence>
    <sequence length="571" mass="63004" checksum="422A1D6AB47C4907" modified="2025-10-08" version="1">MSDETAMMTEPAVSQNISNGSNGVVQALLTDLYQITMAYAYWKSGKMNDPSVFDLFFRKNPFHGEFTIFAGLEECIKLLKGFHFSKSDIEYLRTAMPPGTDPGFFDYLASLSAQDVTLEAVPEGEVVFPKVPLITITGPLPVVQLLETPLLNLVNYASLVATNAARFRMAAGPETVLLEFGLRRAQGPDGGLSASRYCYLGGFDGTSNVLAGKMFGIPVRGTHAHAFVTSFITLNDLQTRNLKSKDGSKEIDFVSLCLTYKKELSSVIDFLPDQTIEGELAAFISYACAFPDGFLALIDTYDVIRSGLPNFCTVAMALNDLGYKALGIRLDSGDLSYQSNVVRAKFVQIAAHYSLPWFERLTIVASNDINEDTIHSLNQQACNLCEVTSHTQPIIQGHTINCYGIGTHLVTCQKQPALGCVFKLVEVNKKPRIKLSEDVEKVSIPGRKKVYRLFGADGTALVDLLQEESEPAPEIGKRVLCRHPIQESKRAYVIPADVKLLHKVWWKDGQVGENLPSLTELREKTKLSLSAVRQDHKRALNPTPYKVSVSSSLYTFIHELWLESAPIGELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0V8</accession>
    <name>A0ABM1W0V8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101862068</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828301.1">
        <property type="nucleotide sequence ID" value="XM_035972408.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862068"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055475">
        <property type="entry name" value="DUF7047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23088">
        <property type="entry name" value="DUF7047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="496"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828301.1"/>
        </source>
    </evidence>
    <sequence length="776" mass="87404" checksum="FB0E374B06348C8B" modified="2025-10-08" version="1">MDMKTTEGFEKEIQSWIEEGILLPWNEKVEIGIIPLMAVVQPTKNKVRPVLDYRELNKYISSHTGGDFTDVCGETLREWRQTTDAATIVDLKGAYLQIRVSQDLWKYQLVNFKGKTYCLTRLGFGLTSAPRIMTKILKTVLNKDEKIDSATQSYIDDILLDESKVTSAALVKHLANYGLTTKEPEPLDGGAALGLKLKSDSTGDLIFSRANRIPHAVFKVTKRELFSICGKLTGHYPVAGWLRIACSYIKRRANGTNWEEIVNDEVEKMLKEMLSRLTNEDPVKGKWYVPKATKGTVWCDASSIGYGVLLEVNGNAVEDAAWLRKPSDFDHINVAELEAVMKGVNMAIKWNISEIEVITDSATVAGWIKTVLSEERRVHTKGAAELIVKRRLGILKSLINEFGLVLSVTLVPTRKNKADILTRVKKEWLSTGGYGMEEGEPEPCVCATGHLDLKDLHDMHHMGVDRTLYLARKVLPETSRADVKKVVQACEQCQSIDPAPVVHEAGNLDVATDWTRLAIDITHHHQVPYLSIVDCGPGRFAIWKKLRRETAGFVTEVVEELMLERGPVREILMDNGTVFRSDCFWQMLQKWNIKPLFRAAYRPTGNGIVERHHRTVKSIAERGNIPPQEAVFWYNSTPRAGLDPASVPQRAVYRYDWRNHIVVNEEEDGPGRFEVGDDVWVKPPQSKCTTKWNRGTVTGVNSINNVAVDGMARHVLDVRRVVRDVTSEEEDDEGGGGEQQTLQTLTRNEGAGEPPPRRYPDRVRKTPGWLVDYETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1B5</accession>
    <name>A0ABM1W1B5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Y-box factor homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828458.1">
        <property type="nucleotide sequence ID" value="XM_035972565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854444"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828458.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30386" checksum="85AB38A0557A847F" modified="2025-10-08" version="1">MSGALRSTPNAACKIHTNLEPLDMRREAAVVEINNLFLFFRDDTKEDVFVHQTAIVKNNPRKYLRSVGDGEKVEFDVVEGEKGNEAANVTGPEGSNVQGSKYAADRRRFRRGGWYPRFRGGGRGGRPRQDMDDGAPDFMPSPRGRGRGRPYYQNRRYFGPPRRGGGRQYLEGEGEYQLQRDQGFRGARRPFYRRYYGPPPRGYYDGGYYGYQGGPPRGGPRRRGGGRGRGGFRRGRGQNRDKDDGAAPKADASNDTVKSEPSSTSVESKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3Y3</accession>
    <name>A0ABM1W3Y3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478950</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829376.1">
        <property type="nucleotide sequence ID" value="XM_035973483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478950"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829376.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17759" checksum="F5A9F5AA15D089D8" modified="2025-10-08" version="1">MTVMNEQPMIFKFPQIWKGWPQQLNKANTDKMAPGEIKAMTKRCLLSTVFNDKRKVSVLSTNSSPGVSTVTRRVKGGVQHIEIPNSVLNYNNHMFGVDLADQLHSYYAVGRSGVKWLRYVLWFVVTPETPYGCSICKVHLHKGLCFASFHKELASAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>O61471</accession>
    <name>PGK_APLCA</name>
    <protein>
        <recommendedName>
            <fullName>Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PGK</name>
    </gene>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Learn. Memory" volume="4" first="478" last="495">
            <title>Identification of specific mRNAs affected by treatments producing long-term facilitation in Aplysia.</title>
            <authorList>
                <person name="Zwartjes R.E."/>
                <person name="West H."/>
                <person name="Hattar S."/>
                <person name="Ren X."/>
                <person name="Noel F."/>
                <person name="Nunez-Regueiro M."/>
                <person name="Macphee K."/>
                <person name="Homayouni R."/>
                <person name="Crow M.T."/>
                <person name="Byrne J.H."/>
                <person name="Eskin A."/>
            </authorList>
            <dbReference type="PubMed" id="10701873"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2"/>
    <dbReference type="EMBL" id="AF042738">
        <property type="protein sequence ID" value="AAC13267.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191644.1">
        <property type="nucleotide sequence ID" value="NM_001204715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O61471"/>
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        <property type="protein sequence ID" value="XP_012936693.1"/>
        <property type="gene ID" value="LOC101859700"/>
    </dbReference>
    <dbReference type="GeneID" id="101859700"/>
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    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ADP binding"/>
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    </dbReference>
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    <keyword id="KW-0067">ATP-binding</keyword>
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    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
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    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000145842" description="Phosphoglycerate kinase">
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            <begin position="1"/>
            <end position="412"/>
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    </feature>
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            <position position="20"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
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            <taxon>Euthyneura</taxon>
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            <taxon>Aplysiidae</taxon>
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        <scope>IDENTIFICATION</scope>
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    <proteinExistence type="predicted"/>
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            <end position="405"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005089463.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="45854" checksum="643685C847D6BFC0" modified="2025-10-08" version="1">MKRKVYVKQLHQLKAAQATANQIKKKAREMSCIPSNTPQNTTSVIKRSTRNSVNKNSDSPPTALPNVGVLMRGSSSSSRERQNCVHEEPSSSGSSASRVTSEQRRKMKGDAIPTVVEATSADIPLGSEPTEQPDDVDNAVNGDPVRPLYEAPPSYTYLTAATNVKYGATSASEPAHGSDPDQYGVPPGMNYVIVPSVVDSVPTSAPPQYTQTVLERSTFGDHSNFTHPVPYPSTIACHQEPFEGRSHDVKSGHSTEENGDSLGSTETYSYPNHATTWEQENGRYVSYTWKNHDVDVYNNNNDVSLTNNNVQYNVTSPQEGMKRRSSSHIRDASMIKLSSSSSRRRRKRVQTPVQRSAANMRERRRMCHLNVAFDRLKERLPNVKDKKKLSRIQTLKAAIYYIHLLRDSLNMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCD2</accession>
    <name>A0ABM0JCD2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101861409</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101861409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090431.1">
        <property type="nucleotide sequence ID" value="XM_005090374.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861409"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005090431.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27870" checksum="84C1B8E280E29C0D" modified="2025-10-08" version="1">MASPDEELMDSESTDVFDKLVVRSPGKFENFEKIDATGKYLPFYGYTIINMVVEQQLHDLELFIKSTQTLKKYVSALPSSSYHVTYYDIFSQRKIPEKYLSRSGLVPSNHWTQSMETLYQDLGKAQTFCSELPAANAFVKKQFSLGPSPGQALLLLITLEGDAEVSQLRQKCTTVFGERGKPEFHMTLGYTYKAIPVDALKLISKELKMLWSIIPDGVQLQKPDVYYFETMEEFLPFKLRLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCS4</accession>
    <name>A0ABM0JCS4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Transmembrane protein 50B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101849743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090730.1">
        <property type="nucleotide sequence ID" value="XM_005090673.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827935.1">
        <property type="nucleotide sequence ID" value="XM_035972042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849743"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005090730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035827935.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17685" checksum="10E3F50243BA3A24" modified="2025-10-08" version="1">MSGFLDNCHWPRCECIELGDRRNLIVAIASGVLFFSGWWIMIDAAALYPDGGQFNHAYQTPGVVLTVAFFMINSVSNGQIRGDAYTTGCIGQTGARVWLFLGFLLAFGALIAASWILFGFYVVEYVQPDWPGIAVFLQNALIFFSAFLFKFGRTEDLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD52</accession>
    <name>A0ABM0JD52_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101860305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005090962.1">
        <property type="nucleotide sequence ID" value="XM_005090905.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860305"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17974">
        <property type="entry name" value="DEXHc_DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="290"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="479"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="789"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005090962.1"/>
        </source>
    </evidence>
    <sequence length="926" mass="106620" checksum="ED3EF0E44D0DA593" modified="2025-10-08" version="1">MEVETFKAPKFGSRSKHLRKKKESSSSESDEEEEESEEDNQGASSDDDSDPDMERKKDLKERDEFAKRLRDKDKEKTRSVMSKSDKKAYEEAKKRLKLEQEDRKKIIPELRKQSRRDYLKKRGNDKLEDLEADIEDEIRFFGKEKLTKREQKDLEYKKTVLKLAKEHRAAGELEKVDRYYIPKDDVKPQEKYVEDKSEQRMGSEQSRWEEEHLSAAIMKFGAKDAKDKKKSKDYEVIMDEEIEFVQTLKMPGTVKDKVKEKKSAPKLDKKSSIEETKKSLPIYPFKKDLIRAVRDHQVLIIEGETGSGKTTQVPQYLHEAGFTKKGMKVGCTQPRRVAAMSVAARVADEMGWKLGNEVGYSIRFEDCTSERTILKYMTDGMLLREFLSEPDLASYSVLIIDEAHERTLHTDVLFGLVKDISRFRPDLKLLISSATLDAQKFSEFFDDAPIFRIPGRRYPVDIYYTKAPEADYLDAAVVSVLQIHVTQPMGDILVFLTGQEEIETANEFLLERTRKLGSKIKELIVLPIYSTLPSEMQAKIFEPTPPNARKVILATNIAETSLTIDGIVYVIDPGFCKQKSYNARTGMESLVVTPVSKASANQRAGRAGRVSAGKCFRLYTAWAYKNELEDNSVPEIQRTNLGNVVLLLKSLGINDLLNFDFMDPPPHETLVLALEQLYALGALNHMGELTKLGRRMAEFPVDPMMSKMILASEKYKCSKEIITIGAMLSVNNAIFYRPKDKIVHADTARQNFFVPGGDHLTLLNVYNQWEETEYSTQWCYENYIQHRSMKRARDVRDQLEGLLERVEIEVTSNQNDTVAIRKAVTAGYFYHTVRLTKGGQYKTVKSQQTVMVHPNSCLFEEHPRWLVYFELVFTTKEFMRQVMEIENLWLLEVAPHYYRAKDLEDGSGKKLPKKMGKAKEDLVRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD78</accession>
    <name>A0ABM0JD78_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">28 kDa heat- and acid-stable phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091019.1">
        <property type="nucleotide sequence ID" value="XM_005090962.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853992"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091019.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21837" checksum="9FEDE9D87A29567B" modified="2025-10-08" version="1">MPRGGGASGGRGGKKNHKGQRRHFTDEDELKQQAQKNEREKEWRRQRGIESEEEEEEKDGEKAAAGAKNRDMPPSDSSSESSSESEDEKPKGVQHLINIENPNRMGGKSTKKVTEMGESGGSNLSRREREELEKQEARRRYQVLHAAGKTEEAQADLARLAIIRKQREEAAKKKEEERKAKEAAKDAASKSKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD92</accession>
    <name>A0ABM0JD92_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC101857763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ECSIT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091035.1">
        <property type="nucleotide sequence ID" value="XM_005090978.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091036.1">
        <property type="nucleotide sequence ID" value="XM_005090979.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857763"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029342">
        <property type="entry name" value="ECIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046448">
        <property type="entry name" value="ECSIT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113:SF1">
        <property type="entry name" value="EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14784">
        <property type="entry name" value="ECSIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
        <property type="entry name" value="ECSIT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01284">
        <property type="entry name" value="ECSIT_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ECSIT C-terminal" evidence="12">
        <location>
            <begin position="325"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005091035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005091036.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="55039" checksum="34B7EBA02A15EF3F" modified="2025-10-08" version="1">MYSPITALVRRQLNFNELSLCLSVCRKYASKSKYSYRKLIESTPPSRQTYSCIRGLHVSLRPSQKEVPSQKNELQEQKQEPELVAKEAKDLEVKLRVPAPRSQQEEWKSSIPDHDPGRITGVGEKLERKALSIFDDEANTRGRNKEAFLVAVSKYISKETLYRRGAVEFVYAGLQEMKTFGVVRDLASYKALLQAFPKGKMIPRNAWQVEFMHYPRQQQCAIDMLEQMEVNAVIPDDEFGVLLKDRFGNEAHATRKYRRIMYWLPKFKNMNPYPVPFDLPENDEELALIALRRMCVDKETRYTVWKTAEEELECEEDTFVASAQSPTQQELLRKHKSEQPVFVEGPYPVYLRTHRLQYFLLRAEPNINALMKQMQLEKEAENDENLFEWTNFFEEEDCRELQPVLSVHEQEDSTVLALAVTGSSSKTSLVSWVRLLQRSNPSLARTPVLFKLLSSDRELEVIGDNRAFKDFDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDQ3</accession>
    <name>A0ABM0JDQ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Terminal nucleotidyltransferase 4B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101856779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091309.1">
        <property type="nucleotide sequence ID" value="XM_005091252.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856779"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="5">
        <location>
            <begin position="111"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="4">
        <location>
            <begin position="304"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="511"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005091309.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="85897" checksum="3F5C5A777028A18B" modified="2025-10-08" version="1">MDPRIAWYPPEQLGPAHDLWTRIWETQYCLDSMLLGSSSDQKPQEFIPLDEPTDSTDPHKRLEAQQKRKRQDNRACTFGLNFPLNTRILRDGGLTPWRKDDRIYGRGIIGLHQEIEDFYEYMSPQDQEATMRNAVVERLTSVIQGLWPEAKVEIFGSFRTGLYLPTSDIDLVVFGNWNSQPLFTLKNALLEKKLAEPSSIKVLDKASVPIVKLTDAESEVKVDVSFNMDSNQNYGVESAQLIKEYMDKYDCLKYLVLTLKQFLLQRDLNEVFTGGISSYSLTLLVISFIQLHPRGFTANNVKPNLGVLLIEFFELYGRNFNYFKTAIRIKNGGAYLPKEEVCKEMENGYRPSVLCIEDPLKAGNDIGRGSYHAMFVKNAFEYAYLVLNHAVAPHNLHLTTERESILGRIVRVTDEVVEYRQWVKDKYLKKVKLNKENVMPGFSHSGPKSLLSLPTCEPTDLVHAIPVPLSSPDGLGSGMSSPKKSQSQQQSQGATYAAIASGKAEVTRSASAGALNEVRKSSSIASQEGNNESEGSESGGNSSGYKSSASSDDEDYETGEEGVISRQAIPHHSGDYPGPAPSAKGNRSSASSGLHPIQSQEYYRSRESTRMNPPLSNGSGMGKAQRDTSASSVSSTRSNNGNNSGGGGGSGVYGAHHYPPSGYSGGYNGASASQHESSPAPYYPAPNQQQQYLVSAGPGLARESRDLRERYNNYNGGVHQAPLHHNHHRPPPGPFPGSHQNNNVRANGSKTYSRSSGNNKQRRKKGRDNSANRGASNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDV7</accession>
    <name>A0ABM0JDV7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">39S ribosomal protein L11, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101862555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091429.1">
        <property type="nucleotide sequence ID" value="XM_005091372.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862555"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="8">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005091429.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21559" checksum="11E966EC559F8712" modified="2025-10-08" version="1">MAARRAVGVVSDQVKRKTFLRRNIPAGKATPAPPLGPELGQMQVQIAAFCKDFNEKTAHLKPGIPIPTEVNVNPDRSFNIAFLKPPVSYFLLQAAGSQKGATKPGQQTCGIITLKHVYEIAKIKSEDPAFATYTLEQVCNSIIGQAHGIGIKVVNNISEPLDVEELREFKVQRALEVEEEEKELEELRLSKMLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEL5</accession>
    <name>A0ABM0JEL5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101863722</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091958.1">
        <property type="nucleotide sequence ID" value="XM_005091901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863722"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091958.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12177" checksum="6307B2D870CA30B6" modified="2025-10-08" version="1">MSQRKKPVFGRRVRKRRGREVLPPPDPADLAKGQIVTDVRNSDDMIQAVRDRMCLWPTGDELICLLTMVQSEQSSESWRDTVQPPPAPPPEETPEEIPDKKFGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF30</accession>
    <name>A0ABM0JF30_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101851710</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092248.1">
        <property type="nucleotide sequence ID" value="XM_005092191.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851710"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113">
        <property type="entry name" value="AGAP001705-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113:SF4">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046727151" evidence="1">
        <location>
            <begin position="21"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005092248.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24089" checksum="CD1979807B730322" modified="2025-10-08" version="1">MATILQIVTLATVLLVQVRGHGRLIEPPSRSSMWRYRFDNPVNYDDNQLYCGGYDHQWRVNQGRCGVCGDPYDGPRENEAGGTFANGIIVRQYQEGDIINVKVQLTKSHLGWFEFRLCPNNNVNRAVTQECLDSNLLESPNGFTRYNVRSWDAMVHSLKVRLPRGVTCTQCVLQWKYNAGNNVDCDSNGNCCKGCGPQEQFYGCADVSISPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG62</accession>
    <name>A0ABM0JG62_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine-rich cell wall structural protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092950.1">
        <property type="nucleotide sequence ID" value="XM_005092893.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854478"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092950.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="28223" checksum="30C7F5DB0998566C" modified="2025-10-08" version="1">MFAPLKTETHLEDPPSPPPSQFSMDPRIHVLIPFLYLTTHVRADETRVLAASVKGLGGAGLTNVPGLGTGVFLDRDDTDLVFAKTGLVGNTGNIGVVGGGAGIGTGVVGGVAGGIGGGVIGGIAGGVGGVPVMGGLGGLGAGGGGNNVVTVVDVGGQGGGGLGGGIGGGLGGGLGGGLGGGIGGGIGGIGGIGGIGGIGGGLGGIGGGLVGIGGGLGGGLRLIGGGGGGGGGGRAVAVGGGANIVIKGGNVSTRSIRQPSFVKYVVPGRKRFLGPGYGPVFYGRKGISKRRFIYSKRRRFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG95</accession>
    <name>A0ABM0JG95_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger BED domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101848025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005093008.1">
        <property type="nucleotide sequence ID" value="XM_005092951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848025"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005093008.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="62072" checksum="1FB4978120870178" modified="2025-10-08" version="1">MSAKPSLCWKLITQKSGGVGGAKIAVCDVCKCELAYSGRSTTNLLRHLRKKHPLHIAQFEEVSESSSTTSVPAAASSSTTQSSAPTAGPSRSTQPTLFDTIERVTKYKPGSDRKKELDNCVLDLVTVDLQPLSVVENTGFRRLVNKLDPRYDIVSRKTLSTQLLPMKYRAERDQLRRQMDEVNHLTVTTDCWTSRKTESFMTVTVHFVSPDWKLTSRVLNTVLLETTHTSENLAAKILEIFTAWGIKDKVTTIVTDNAANMKLAVELMRCRHQPCFAHTLNLVVKESIRKTYDVFTAKNKVKDIVSFFHHSVNASNLLKEAHKAKNTTPKKLKQDVETRWNSTFEMLKSYLEQHEQVTTALCLNGKQDMCLSPIKLPVLQKAMEVLEPFHEATVEISTEQHTSVAKIVPIVFLLRRLTAQDRSPLSNCLNSQLSQRFENIDEKTHLRLATLLDPRFKRDGFPTTASANSAVDKLKTTAMPIALPQQPGQIQTTASKEETTAPPPAKKVSKLWTQFDQAVKGKQAAVPRVAGVESEIRRYLDSDMMPRDSNPLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIL8</accession>
    <name>A0ABM0JIL8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rab3 GTPase-activating protein non-catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP regulatory subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094482.3">
        <property type="nucleotide sequence ID" value="XM_005094425.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861108"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026059">
        <property type="entry name" value="Rab3GAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029257">
        <property type="entry name" value="RAB3GAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032839">
        <property type="entry name" value="RAB3GAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472:SF0">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472">
        <property type="entry name" value="RAB3-GAP REGULATORY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14656">
        <property type="entry name" value="RAB3GAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14655">
        <property type="entry name" value="RAB3GAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="6">
        <location>
            <begin position="79"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP regulatory subunit C-terminal" evidence="7">
        <location>
            <begin position="790"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="876"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005094482.3"/>
        </source>
    </evidence>
    <sequence length="1456" mass="162087" checksum="DFF2407BBD34444F" modified="2025-10-08" version="1">MSCQLSAISKFHDISTVRNFFFPSPSKESTPNRDEGGEDSVSTSMNEDWNAAWGFDDEKVMVQEAEVGDGSCEHDHNKWLQSCLVSLSPTNDVLAIAHGSKICIMTQKWDAKNKGEEIDTRLMPVWEANLGLDEKETITAVLCLPLASQKRSTQGGPDWTCIIVGFSSGYVRMYSQTGVLLLSQLLHLEKVERLKCRTYAPPRFLGMAETHDELLIMYTKAIVSIDGFSLIQTLRACRNQVARATASGTENLLQPPPLAYKKWSLGDQERVGDYVACGVVCANPFDQLKAASMLGGMKAAVKTSPPAMSVFLTSGSGPYVGFFYAIEGFAQPILSEVAIAMANKIKSALLSAASGWLGFGGKAKEEKEKPPKIEPATPLPLRFGLPDKRRCGEMIILSPNNNFAATTDSFGRIILIDVQRGMAVRMWKGYRDAQLGWIEVKEESVEPGKNNDHYRLAQFLIIYAPRRGILEVWLAAHGPRVAAFNVSKSCRLVCPCYGMMGLNNVTCRGVRSRVFQCALIDPDGVIKTIDIPFHLALSDKSSKRARDLHLLKKLKTFLKESSEDREGLQETIIELLLDLKVSSIAHQAIERVLSTRYLPVKVMQNIVRASIKRLEARGDETLDLDSRMMLKFCKAQRSLLALYASVQKLNSGQIEENRLSASEILTDVLRNSSREAAMVLKTLLRLDALTTPPSPERQPSRVTFNDDRQPIAATSFLHAFSYRSLFSTEEDPASASPPSGKLTQITISKEATEERRLALAEFLFGGCLRGTCQAPELVSVIQESGLPPDQLMNLLLLHWLSESGRSVSSLGSLYELVKSITAMTDVNEVVVDSNEFSAWWTRVRNMCSQSVNCRAAYLAVLVCKAVAAHALGVVPKEKDPDADSASSTSDDNEAGDGTKLSSDLSLDSQDWETVTVDMESWEVLLKQCEDVLAITTLLNIHTEEVAGSAGSEQITVSVSKLLQSGKGSVPEVIARYVVQQHLNPASLFYNYHSQENVEPDDGEEQSGDGDKEKKAGDQNEAAKNEEDSLSEESMEEKIRDMSQSDRVKYQLEELRQRFPHSLHNDVLLANCCWEYAVGWNKNPEKTQNLELSLEFLRLVHNAVLRQGVSSLLWHMFVRKKVSAAAHLMEKVGKPPKDRLCRKEVHISDTALVTFISLCSDFVEIIMDANCEANEVPVCNMEPAWQKVQGPASLLELAIDQKATNYGLLKVHQHLLKIMSAMLTLGIKSVKVLSLFDNKGRAALFKELHSHPLLPNQKVEHELFLARRSFLCKVITYAVGTIDPPPEHTPGQPTMGTSPPVYKRQRSLFPNAFKWPQEVLALAKDFGLDLDYLKRHHVCELYSYGHDRLAEEAMNTVNDQEEMGLQLMNMAGKRLAYEIFKRDIDKNFQHLAGMSPTLTRWMKTLDLNTLHFPLVPLSNTVLLAEQAAARLNESSVHHELSQELFEQTKMVSDFQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJP3</accession>
    <name>A0ABM0JJP3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TNF receptor-associated factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101856795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005095243.2">
        <property type="nucleotide sequence ID" value="XM_005095186.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856795"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012227">
        <property type="entry name" value="TNF_rcpt-assoc_TRAF_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015614">
        <property type="entry name" value="TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="12">
        <location>
            <begin position="128"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="12">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="407"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="128"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005095243.2"/>
        </source>
    </evidence>
    <sequence length="574" mass="64802" checksum="1506CB61F9F44FA7" modified="2025-10-08" version="1">MALQVNAPVFNENGDRKAGGFFPGIFSAGFDHKFLCCHCHCILRDPIQGYCGHRFCRSCRDELLRTQDSNLLNCPGCVEENVGPQEMGKISENRMFPDNAVRREMYNMAAACVFPGCTWRGKFRDYEAHEESCPFRQIACAQCAQPVTDGRMAEHRANECPQRLVLCEHCGMELMFARLQPHLEVCEKFPLVCERCGQADILREQMKEHLEKHCPKRLISCPMGCPEQFNMDMFSDHIHKSIESHLVWTVQKMMLLEQKFEGGMAQPAGLMQVKGEMNNIEKKLQAVERQLKNMTVPKSSSTSSESSQDARAEGGTGQEGKPSKVSSEVAAKTSLRLIEPIVAVLHSELDKAIHSLQILEGHFRQQQAQLDELESRFRAQQQSLSLVDASKADLEMRLAAQEKARYDGTILWKVFGFESKKKEAITGQTTSLYSPAFYSGPCGYKMCARIYPNGDGIGKGSHISLFFVIMRGNYDALLPWPFSQKVTLMMIDQNHKEHIVDAFKPDPTSTSFKRPTTEMNIASGCPLFLPLEKLHSRQHGYLRDDTIFVKIIVDTEGLDRFTEMNPGRFASGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJX5</accession>
    <name>A0ABM0JJX5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6 20">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 20">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">Mitochondrial translocator assembly and maintenance protein 41 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101854785</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Mitochondrion inner membrane</location>
            <topology evidence="2 20">Peripheral membrane protein</topology>
            <orientation evidence="2 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 20"/>
    <dbReference type="RefSeq" id="XP_005095408.1">
        <property type="nucleotide sequence ID" value="XM_005095351.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854785"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 20" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 20 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16 20" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR028840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_005095408.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48886" checksum="A1982DD8CB849B47" modified="2025-10-08" version="1">MASVHRICSMRGHLYTFSFIRYIRGQFMSQSGGSHSETASQWKSFTSCVTGRSTLSLECGSVSQLRVSSIRRLASVPDLAVTVETEKKSQEANILFSSSQALVEENPQRSLYRDIVHEFPDGIQMAFAYGSGAIQQGNANDKSKNMLDFIFVVDKPRRWHRINLERHPHHYSFLKHFGPRTITRIQERYGAGAYFNTLVPMAGRTIKYGVISTARLVTDLLDWESLYISGRLHKPVSFVVIPSDENLLTALTVNLRSAVHAALLLLPDMFTEEQLYLTIAKLSYAGDFRMAVAEDNNKITNIVQPSLPLFRQMYSSFLLEDVHSTWWPQEGQLEQALTFESRHHHLKCLPTKVLYGLLMQKYQIGVFPDLEEIIKLHAYDSDCGSHVAQSIRHIVKRSSVSQSLKGILTAGVLKSLRYSSSKILKKVRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKR4</accession>
    <name>A0ABM0JKR4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101862493</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101862493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096021.1">
        <property type="nucleotide sequence ID" value="XM_005095964.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862493"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005096021.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11411" checksum="761FA0227B408217" modified="2025-10-08" version="1">MSAPENPRPEADDFIRCMFHLEVAATRTTIIQLADCSMRVSIGHLKEDLARYFGDPAGQVWSVEDRVFEDDRTFGSYCVDPSHDELRPLRIVVRISQPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JL84</accession>
    <name>A0ABM0JL84_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101852683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005096331.1">
        <property type="nucleotide sequence ID" value="XM_005096274.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852683"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF8">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="5">
        <location>
            <begin position="64"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005096331.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="55055" checksum="7798F2B89130F172" modified="2025-10-08" version="1">MADDKNKLLPHRLVHLDLKGAPLCVDYLEKVFPLLKRWGTTGLLVEYEDSFPYSEELKVLAAPHAYSKEEIKQIQTLAADNDLIIIPLVQTFGHLEFVLKHEEFFPLREVEKYPMALCPSNPDALSVVCKMIDQVMALHSGVQHFHIGCDEVYHLGLCKTCKSRMADGSLSKEQIFFSHVREVATHVQKNYNGVMCIVWDDMFRFSELPVILNCRLGGLVEPMIWHYVPAFMLPNDLWENLSAIFPKIWIASAFKGATGPRAAITNIRYHLDNHHAWLETLRSMSQKFKAIQGIAITGWQRYDHYAVLCELFPHGLPCLALCLRFVEQGTLSPTDVEFVGKELEFTTPLPINPFASRDVPACDFPGSLVYQMTIEFVHAEATINEFFALEGIASWMHEYNMERKFINPVHVEPLLARAESLLESLHGTQRKISPAFTGVFVSGVEQEWKGLFVQPLVKRLEDFIEKAKTFLAPPAITNQVENNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLQ9</accession>
    <name>A0ABM0JLQ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Group XIIA secretory phospholipase A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005096638.1">
        <property type="nucleotide sequence ID" value="XM_005096581.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863338"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010711">
        <property type="entry name" value="PLA2G12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824">
        <property type="entry name" value="GROUP XII SECRETORY PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824:SF8">
        <property type="entry name" value="GXIVSPLA2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06951">
        <property type="entry name" value="PLA2G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045349834" evidence="3">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005096638.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19689" checksum="20EA56493A5FD4F1" modified="2025-10-08" version="1">MPRLISFPCVVVLLVAALSASCSAQGSISDDVGNILSSIRNVVGNLEDFVGDRNGCKFECKNGAKPKPRPYYTPTSNGCGAFGIKLEDHIAIKGVTKCCDEHDFCYDTCNNDKDTCDRVFKKCLQRICKKVKGMLTDNVYEGCKSTADLLFAGTVALGCKPYKDSQEKACVCKGGFANRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM69</accession>
    <name>A0ABM0JM69_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Insulin-like growth factor 2 mRNA-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101863015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM IMP/VICKZ family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096966.1">
        <property type="nucleotide sequence ID" value="XM_005096909.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863015"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22400">
        <property type="entry name" value="KH-I_IGF2BP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22401">
        <property type="entry name" value="KH-I_IGF2BP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22402">
        <property type="entry name" value="KH-I_IGF2BP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22403">
        <property type="entry name" value="KH-I_IGF2BP_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="81"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005096966.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="64344" checksum="1B1C614DE8966DEC" modified="2025-10-08" version="1">MMEKVFLGNLPGDVNESTLRRLLEQQGIIFNSISMKRNFAFVTVKDKYTVDDMVKKLNGYTLEGCQLQAEPSNGKKRPRTNKIQIRNVPSHCSKEQIEELVNVTSRNHKKFEQVGSEGAIYVTFSTPEEAEECVEQLNDYRFEDGTQLKVEFFRNQKRSNRSNSSSNPGVSRQELPLRIIISSDYVGAIIGKQGLTIRKITSESRARVDIHRRESHIPDTMVTIKGSPESCSKACQEIMRVVQEEAESLKRGNVPLKMLCPNSICGRIIGKQGNVIKVFMEDTSTNIVVSSFDPYPGGLMDTGNNYMDRVITISGSTENCSKAEGKISEKMRQCFEQDVGSFQFGPQQHLMFSGMPGLPLMPSMSPFQSMRPPMPYMGSAYYPATLGGPSQAVQQPEVVQLYIPEKSVGAVIGSKGQNIKNIMRLSGARIKILGANDKNGSGENNPFSNSGDERKTVISGSPEAQWKAQFYIFEKVKNELRLAAHDEVHIRTEIVVPKQSIGRIIGKGGQNVKEMQRVSGAIVQLPGEDPDVDEVPVTIIGNFYAAQSAQRRVRSLMAVFLRAQPAPRRARPGAPQQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM86</accession>
    <name>A0ABM0JM86_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101848041</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101848041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096988.1">
        <property type="nucleotide sequence ID" value="XM_005096931.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848041"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005096988.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36889" checksum="C54F61BB45656596" modified="2025-10-08" version="1">MSKKDRKRVLAQIWGTPTSHDIDMVDEGDQIVVFSNYRGIINWWMEIFKTYYPNIKCREKGDVIKIKPTVGVTIKLNKTTKLMRVSGKDHWPWFVDTFEALLEVGNGDAIELPSDGGSVSENSVTRYLQLNKEDEEVQDLLDRIPDGGGIMHHEFIMRLWKTLLDDWFGVGANVFVVTPRIDSERLFTIMLLMIRNKGTGFKVTLMTPFKQDGDRFDKIMDKTKRRMKEVKTAQDSRLVSDVKLQWVINTLEIKHEDFSTNFVAAYKDEEAEVLTTTAHFHKAHFHHQQKDNVCYNRLSPHDLRKNYLLPLDIGSNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMF0</accession>
    <name>A0ABM0JMF0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005097114.1">
        <property type="nucleotide sequence ID" value="XM_005097057.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858103"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF378">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005097114.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41939" checksum="ECB2AEF15DCA7352" modified="2025-10-08" version="1">MVLKSMVSRRAPLLSTLGISFVVLVLIYNANKDNILSASPCATQNRQHTRNTAQLISQNPFLNSTVPSEKPASASIPVSTSSRKTYAHIIQETPPNAGPEQGFALEYLDQEVQKAVETKKAAIRLLSSPIINQHNMMYLVGREQKCTNMTPEVIITVPSGWGNFEKRQKVRDGPQGKYVRAHSQNALLLFFVGLPPAGIGKNKTQKWAKLQEESEKYADVVIAYFEDKYRNILFKHLSMLQWVINFCPKAKFVLRTDDDVGVKIDSMLVSLRRHSDERQNFILGKQRVGDAPSRREERPHYYLSEEEYEPDTFPPYVLGGAIGYPVSTVKLLYEVARRTKNVWLDDVFMTGICAAALGIPTFNERSFQFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNA8</accession>
    <name>A0ABM0JNA8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Transaldolase</fullName>
            <ecNumber evidence="3 7">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101855018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 7"/>
    <dbReference type="RefSeq" id="XP_005097705.1">
        <property type="nucleotide sequence ID" value="XM_005097648.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855018"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005097705.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36254" checksum="2A70E7A96AAEB8A3" modified="2025-10-08" version="1">MSEAKKRAVSALDQLKEITTVVADTGDFEAMKQFKPTDATTNPSLIFAAANMPAYQKLIDEAVSYAKKLGGKEPEVLSNAMDKVCVNFGAEILKIIPGRVSTEVDARLSFDTEAMVQKAQTLIKLYKDAGIEKERILIKLASTWEGVQAARILESQFGIHCNMTLIFNFYQAVACAEAGATLISPFVGRILDWFVANTDKKSFESLEDPGVKSVTKIYNYYKKFGIKTVVMGASFRNTGEILGLAGCDLLTISPSLLDKLAQSTEEIKPHLNADTAKASDIGKVNVTEQVFRWQMNEDQMATDKLSEGIRKFAADAIKLENVLRQRMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP05</accession>
    <name>A0ABM0JP05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Growth hormone secretagogue receptor type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101860094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005098158.1">
        <property type="nucleotide sequence ID" value="XM_005098101.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860094"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005098158.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="37772" checksum="D2E145BB47FF39EC" modified="2025-10-08" version="1">MASGNESYGTPLGPPQSRMVDDHVLAIIIICFFVIILGTISFFGIVANVINLIVFIRQGFKDTVNISLFSLAISDIGALIPLLWMSIGLNPYFFADPPFDPQEVLYLTSGWPHICFARISGWITAFITLERCLCIAMPLKVKTMITVKRTAIALVSIYVAMIGALLPVFYALRLEPIFSPLKNETKFRTVYIPNGFAIESAVFLINAFSQFVSFIVVIICTIILVQALISKSKWRKSTSSFGDHDSFSNRDKKVVKLVLFIAIIFIVCFLPSAINFLASSLEPEFNTYGKYGDLFVLMWSFSANLSATNSAVNIFVYYKMSSKYKQILDKMLLRSTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP97</accession>
    <name>A0ABM0JP97_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101862648</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101862648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098340.1">
        <property type="nucleotide sequence ID" value="XM_005098283.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862648"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051548">
        <property type="entry name" value="Grx-like_ET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34386">
        <property type="entry name" value="GLUTAREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34386:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN NRDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="5">
        <location>
            <begin position="363"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005098340.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="64061" checksum="452178D92A89F951" modified="2025-10-08" version="1">MVFFSVNYIRTLRPVLLSQKVGTFCVQQRQVGWTFLWLSTTRSIISSRRIGCPVELVRPLRKSATRSILFWTQRTKFRSPPGIIIMSTPLKGTIVVYSILGCPHCMKAKQALKELDLPFSDVRLDLFPHIRDEVSKKSGMKTVPQIFFNNVFIGGNDSLTKLIADKGKLQGYIDELKKNPMPDDGPVIPDPSTAVADADPFSFQCEPDEYFLLMNELRKDNVIRTHGSFFKSKKNGLTGKDFVKWVKEKKDSDEQKAVEIGQALLDRRFVRGEDASGKFSTGSELFTLVEDDESDALNNGPMTECVPKTANEIGDHLRKMILKLYSVFLSADGKAVDYQGMKASDEFQVYKKMTRELLRVDVESASREEKLAFFINIYNALVIHANIERGPPTNLWGRYKFFNSTKYIIGGQSYSLQDIENGVLRANRKGVGQFSNPFSKDDPRLKVALERHEPLIHFGLVCGAKSCPPIKTYSAQNIYEELTLAAAAFVENDDGCFVDVKTKTVKLSAIFKWYQEDFGSNKKELLKFVASHMDAGQKKKDLEELLKIGNFKVSFLKYDWSVNSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPZ4</accession>
    <name>A0ABM0JPZ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Co-chaperone protein daf-41 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098825.2">
        <property type="nucleotide sequence ID" value="XM_005098768.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855423"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="48"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098825.2"/>
        </source>
    </evidence>
    <sequence length="205" mass="23243" checksum="3AC2B2DA554CB2DF" modified="2025-10-08" version="1">MTCANNSCFRRVCCFACDCRHTVGQLYFISVCEQRATKMNSSSNASHVSPPAVVWAQRKDKILLTIQLENCSNPTIDIKDSSLYFKGKGGTGNVDHEVLMEFNKEIDPQACKHQATGREIIFVLMKKEESHGFWPRLLKDSKKVHYLKTDFDKWRDEDDSDVEEQEDFNLDEMMQSMGGLPGGAPPGLGQEEEDSDDEELPDLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSB5</accession>
    <name>A0ABM0JSB5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuromedin-U receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101845171</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005100388.1">
        <property type="nucleotide sequence ID" value="XM_005100331.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845171"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005100388.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44301" checksum="F4495F013AB7E103" modified="2025-10-08" version="1">MEDSVFNNTSVAAKSPRFEKLPGLLSSHDYDVVRIVLLCVIDPLLLLFGITSNAIDMHVFCKMGARDTVTVSFLALAISDLAYLIIGVPETVCFLPSHFFSKSFHDTIDMSSLGIFISRWKQIFYNFSIFTPTFVSVTRCFCVTFPLQFGEMFTRFRTIVVLSVAFVAFVVLYIPILSFHGMKNHYDPRRNLTRLWIYFAPEYAVLQPIHAMLFRNVFVNICFMACCISTVILIINLKSAARTRREITGWKQTDAEPSTKITTQTAKTAGTHTENSTNEDGQTKCSGSRLAAKTFSSRDTQVIKSVIFVTLMFICTHIPVVVFSELIKLFEPEFRYLGRYSNSLLSSAMLARSGIFLSSACNILIYFNFNTKFRETLKALYCGPGRDYDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUK0</accession>
    <name>A0ABM0JUK0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger BED domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101864401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005101836.1">
        <property type="nucleotide sequence ID" value="XM_005101779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864401"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUF659" evidence="7">
        <location>
            <begin position="129"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="8">
        <location>
            <begin position="503"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005101836.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="66156" checksum="086AA41514186F66" modified="2025-10-08" version="1">MCKQNFTYCQRSTSNLVRHVKTKHPIEFETEEESNKRKLQVSRREESTLAITDSTATTSTAPQVQPTLQQTVERTAKYKPDSVRKRQLDEHILDLILLDMQPLSVVEQKGFRKLINALDPKYEIISRKRLTSQLLPSRYQEEKDKLICELKAVNDVAVTSDCWTSRSNEAYTTITAHYITSQWELKSSVLLTRSEGKRHTVENLAAELRDAFQEVGIERKVSTVVTDNARNIVNAVEVLMIRHHACFAHTLNLMVRSSISEVEEIKSLVKKIKSIVTYFHSSTGATNSLREVHERRGSKMKKLKQDEETRWNSTFDMIRSYVDQHEEVTTVLCLAGKSSLCLDAADIPAAKDAMSFLEPFYEATTELSAEKNTSASKIIPLVKILSKITAKNTSSLSKKLHELLHIRFGDVEDRTHLKLSTLLDPRFRQSGFLSTERAAKAVEELKGAVESVVLPCDHSKQAEELSTAPPAPKKPSLLWSDFDEEIETSQRTAATTLTAAEMEVKQYLESQGLARDKDPLIWWREHAKVLPRLQVIAKDVLAIPATSVPSERIFSKAGELISLRRSNLKKKNVDMIIFLNKING</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVR4</accession>
    <name>A0ABM0JVR4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Exonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101853866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102661.1">
        <property type="nucleotide sequence ID" value="XM_005102604.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826769.1">
        <property type="nucleotide sequence ID" value="XM_035970876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853866"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826769.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42547" checksum="85EC390531FDFE1C" modified="2025-10-08" version="1">MMATDGASCSFDSWSDADEEAMANLVFDDDQDSDRERRQFDLECDRVLKNKGGPLQQRRHKYLIVSDLGRQHWCEQQLLYSLDPDVYLMRALPGEVVNIEESKEVKEIKSKGSDIHLTRELEVHVPVEVKVVTKEDKWAVKLLNLQAAVVTFHTGGHIAREVPVFGAPFDLGIFVFGIIDELRYDPEHHKVDILELKTRNSQYPPKQSQQRKDQYQVSVYAQLFNELVLGKVSKEMVKKHLGLDLNKPLTADVMEHVRASNLGDKDRENTNLSSLLDTVLSQVQSLACISQASLEYVHQESKKQISLTDFDLDAESLEMSFSHHVKWWRGERGTEGVDIEDCWKCSFCLFSELCEWREYMANKTSKVSHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVZ0</accession>
    <name>A0ABM0JVZ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101861826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102790.1">
        <property type="nucleotide sequence ID" value="XM_005102733.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861826"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005102790.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12335" checksum="E49C3EF94A9AFF3F" modified="2025-10-08" version="1">MLSDGVVLLHDNATPHKSAQTQNLIASFGGEQLKHPSYNSPDLAPSDFHDLFLHLKKFLAGQDFDSDADLTEETRHRLLTSQAAAFYDGGIQKLIPRYDKCLNSSGDYVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWE5</accession>
    <name>A0ABM0JWE5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier homolog 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103103.1">
        <property type="nucleotide sequence ID" value="XM_005103046.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857348"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF18">
        <property type="entry name" value="LD43650P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="121"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005103103.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35569" checksum="34996BF7F9D01012" modified="2025-10-08" version="1">MAFALAQYGSGAVITAVLHPFGYAKVLMQMGHEPLQPEVSTTFFFHKQTMTYPNIFKYIGHIKYVDGFWGLYRGVFPRVLAGTLGNLVQYNIQDKFKALRDQKPKGERVKPEDEDFVPWLQNFAKETSEDTLARCCGVIVSHPFHVIMVRSMVQFVGRETQYNTVWSSVKEIYEHDGILGFFSGLIPRLIGEILTIWLTSFLAQTINKYLVQEKDLKSYTGAACGLVVSHFTYPFTLVTNIMAVNNCGLRASQPPMMPVYNGWVDCLRTLAQEGNIKRGANAFWRTYNYKPTGVAAYKFQPQGAAYPHNSPAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWP4</accession>
    <name>A0ABM0JWP4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">28S ribosomal protein S28, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103314.3">
        <property type="nucleotide sequence ID" value="XM_005103257.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846976"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019375">
        <property type="entry name" value="Ribosomal_bS1m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13447">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13447:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10246">
        <property type="entry name" value="MRP-S35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103314.3"/>
        </source>
    </evidence>
    <sequence length="212" mass="23323" checksum="A2BB6BC97E51E6F2" modified="2025-10-08" version="1">MAASLVRRVLYSPPTTLVYQRFLGSRKLFHTSEDNSDKSNHSSSTPGEEALDKFAKVVEKVKQAQQNEGNVSSASTAESQSPTTAADPTESFASMLRKSKLVSLGEYKDRLVEGKIIEVMEDDLYIDYGGKFHCVCPRPKWNGEKYKRGTKVLLSLQCLEMSSAFLGSDIHVTLLEGDATLLGLRTSRKSNTNRSPQTQVSSVQAARSSHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JX90</accession>
    <name>A0ABM0JX90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101857265</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005103699.1">
        <property type="nucleotide sequence ID" value="XM_005103642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857265"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005103699.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26446" checksum="6FB0B1091AE00E90" modified="2025-10-08" version="1">MFVSLERCLCITWPLKFKTLFTTRKAAVICTAITCGTIVSYIPVQLSQGIREQYDVTTNRTLLMLWFSDDREEIIKYSNSFHRLFLHNASLASITISATLMAVRLRASAAFRQRAASAEPGDKNNSRALSRKDSRVVTMVFMVALACIILLLPSMLFVSARRVVPDLGQQPRFMNLLSTLVDIMFIFSTLNANVNIFIYYNFNSRYRQYLRQHMHCQRIERNSQTETAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYU4</accession>
    <name>A0ABM0JYU4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LOW QUALITY PROTEIN: C-factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101864473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104753.2">
        <property type="nucleotide sequence ID" value="XM_005104696.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864473"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005104753.2"/>
        </source>
    </evidence>
    <sequence length="256" mass="27488" checksum="00D08A50C22DA1AF" modified="2025-10-08" version="1">MPLAAKTILVTGASRGLGLEFVRQILQASAAPEVLIAACRNPSSAYDLQNLAKAHPSVKVIKLDVEKDEDIISAAQETKNIVGERGLNLLINNAGIYDKTDGSELKTQSRENMQRHFDVNCSGPIIMAQKFLPLLEQAAAQNKSQPMSSNKAALINISSIMASQNVTYESGRGTSFHYKCSKSAVTMATILISRELRAAGILALSLHPGWVRTDMGTEKGDISPEESITGCLQVIGSQGEESTGKLVNYKGDVIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYW9</accession>
    <name>A0ABM0JYW9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal acetylcholine receptor subunit alpha-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104795.1">
        <property type="nucleotide sequence ID" value="XM_005104738.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853479"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044988695" evidence="5">
        <location>
            <begin position="25"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="32"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="243"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005104795.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42522" checksum="F631F5D14FD337B4" modified="2025-10-08" version="1">MPRRPLNTAFLLAIASCLPSVVLMTSSYDDYSRLYTEMTTGRYNPHTRPVRNQSHPLTVYVIFHIVSLLRINELDQTMDINAYIDFSWNDEIRTWDPACYSDITVIRPDPSHMWRPRNIISNSVGKSDIFEDNYIPASIKYNGESKWSPGSVFSTSCDMDFTYFPFDQQECRMFFFFYNSEREVKVTKGQQEGRLFTYSTNGEWDIVFSTIEIISSVNKDVPAAFIVRFKLQRRPDFFVFNVVIPLVIMSALSSLVFVLPETSGERASFSTTMLLSQTFFMGTVTGELPHRSDTFPIIVFYIFSLFILNCICVIAAVLQLRCHTRPSKSVASKTYSDVKTAHTAAFQSNKIPFSSQLALVPVYKYCGLSTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYX3</accession>
    <name>A0ABM0JYX3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein DDB_G0271670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101855812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Hyccin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104805.1">
        <property type="nucleotide sequence ID" value="XM_005104748.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855812"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220:SF1">
        <property type="entry name" value="GH21176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="HYCCIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005104805.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="53284" checksum="2823E032F2B4C013" modified="2025-10-08" version="1">MPGVSEQLTEHALRQLNLSHTSWRSGPFPQFESINAQNRFSILALVMQRYNKDLDAFHSHALISACRVSHKLSQTGFSLDSDSEPRIALSPALLVELLISVYYAMFNGHHKAALKAVESVHKRASYELFSDVLLMTNALLNSHRRGNFKLERDDSIAKSTKIAHPRGTSITNASFKAKKLPDDIEFVEGDDVHKLATVDELETEQSVTKALKAKLMNIGGKLGGDRNKNRDSLTPRHDGDSPRGDPMDSVDVAVVKAGGFGSSRRGSGGSSVSGSSKIIVDMLEMQPVRTRGLRNQNGGDFEENGNDSGEAEYCESSDGGSSDKTTATTKIASSSLIFSKKHGISKVSGQAPGSQASSRITSSPSAPGQSSFSSPNLNTSSVNGKPHGDGPDFSSPRAQSEGPVGKDAKPRAPPSLSSMSTPPSSSSSSFPNSSSQAIHSSSSLASEPPHANSSVPHTAAAPSSSTSTHSMPEELNASSSKREKRYSGKGRVNRNSYSTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ90</accession>
    <name>A0ABM0JZ90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysophosphatidylserine lipase ABHD12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105030.1">
        <property type="nucleotide sequence ID" value="XM_005104973.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847985"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="159"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105030.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43895" checksum="03321FEAB3ADE9E0" modified="2025-10-08" version="1">MKTTPLARVLFTCGNSRLEKKMEVHSEKDEKTKPKSSTVIFYAKALWKYVKDHGQGTFSFIKIGLLTLFLLYVAVPIFVRANQWILPKVVFCNILRWPPFINLSHPSDFGLNYTRNFYLHVEDGIDIGAWHTLPKSMHDEKKNIPWESFEDELDNGKIVFLYLHGNSGTRGSYHRVQLYKLLSRQDFHVVTIDYRGYGDSSGSPTENGVVADAYHTYKWLKKRIGKSKIFIWGHSLGTGITTKLTKKLSDEGDHPAGIVLESPFNNIQEAAFNHPFASPYRMLPWFEWIFVDGIGEHGIFFNSEESIESVIPNIMMLHAKDDFIVPFHLGEKLYARAKGTRHHKTGDVEFVDFEGHLGYGHKLIYQAPELPELIRKFVSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZF8</accession>
    <name>A0ABM0JZF8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein C19orf44 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105165.1">
        <property type="nucleotide sequence ID" value="XM_005105108.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859503"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040120">
        <property type="entry name" value="C19orf44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027884">
        <property type="entry name" value="DUF4614"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22409">
        <property type="entry name" value="CHROMOSOME 19 OPEN READING FRAME 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22409:SF2">
        <property type="entry name" value="CHROMOSOME 19 OPEN READING FRAME 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15391">
        <property type="entry name" value="DUF4614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4614" evidence="2">
        <location>
            <begin position="545"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="249"/>
        </location>
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            <begin position="273"/>
            <end position="441"/>
        </location>
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            <begin position="455"/>
            <end position="600"/>
        </location>
    </feature>
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        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
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            <begin position="137"/>
            <end position="148"/>
        </location>
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            <begin position="150"/>
            <end position="162"/>
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            <begin position="177"/>
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            <begin position="221"/>
            <end position="232"/>
        </location>
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        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
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            <begin position="395"/>
            <end position="420"/>
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        <location>
            <begin position="475"/>
            <end position="490"/>
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            <begin position="537"/>
            <end position="552"/>
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            <begin position="569"/>
            <end position="580"/>
        </location>
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        <location>
            <begin position="585"/>
            <end position="600"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15391"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105165.1"/>
        </source>
    </evidence>
    <sequence length="734" mass="80221" checksum="1E845D2D40676D4E" modified="2025-10-08" version="1">MPTGRSSASALLQKVNSQLRGERVPLKTKEEDELAGYLNSLTQKTQHVPSANFEDFGDISISSGKDGMQAITPRGRRSASPAPAPASSKFLKKKTPQGAAGPAASVTGPKAARVVDDDEDEDDRDYRGGQIVIAGKKKAEASPSRPEKSSALNKANALTNKIQGRRADGFPLRRHVSRDSDSESEIGRRPGSADTSIGRDGRKFLKGRKTLDEEVPERGTPSPQLVQRSSSADQKKKTHRRSSKARGEIVRTLGNVYLTSEEESLAEFIHGLSASESSARRPQNLVAKKQQKWRKKAASPGPRQTPSPVQRSRSPSPFKRSPSPFGKLSRSQSQDSDLLDSMASEMMEGPQRHRHDSASSDDPLNINLMDVASLIPVSPRNKKVKGKQSHHGKGQKQSGALASSSGSVFKASSDNLSKAGKNNKKEAKKKPLKKSDSKSSVFESLGIHMVDELLGADGGKDQAGEYDLSDQSEIVTEKSDDRLKSVKNYDSESEIITELGAGSRPAPVRHLSTERSISTQLERSGVARKTNRRAVSDEETETGGDYSDDSFESDSRTVTQSQSVSARSKGGRKKSRRRPASRSESYSHESPRRHKIVMEQREVQVTAGDPLAGVAHRWDARQVGVSVSGPYGLQYVDPAPIATHVVSADALEAMTAYSPSVLALHEMMKAQVELVRNFADIQRGIYHSCLDGIKEDFKYTTLEDTKEYIKQNRKPRMTFKEALELVEQEEGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1K4</accession>
    <name>A0ABM0K1K4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein DDB_G0271670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106605.1">
        <property type="nucleotide sequence ID" value="XM_005106548.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853811"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
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        <location>
            <begin position="219"/>
            <end position="318"/>
        </location>
    </feature>
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        <location>
            <begin position="354"/>
            <end position="412"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="130"/>
        </location>
    </feature>
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        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
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        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
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        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
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        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
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        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106605.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="62357" checksum="52D28C8E70ED135C" modified="2025-10-08" version="1">MLSSCKKKNFGRYLKKANNNSLDLPADRMEERPELRSEGKLKHYLIPKKKPESALMCPISRSTLSPEHRNSSSSSGSTNQMSSPSSGSSKHTSSSWSESSNHHTSSSSSRSSNHHTSSSWFRSSNHSVSSPTRSLNYHTSSSSSSSSDKSSTWSGSSGTHLNSPSRHSGCLSSWRPDKHVSRTSPHSYKSHESSSSSMYQSSSSGTETYVVRKIVRRSNIESQQSKANHDRHVVPTIHHARPLVRTHTGSTSPTQRNTHAHQQTAKKRTPNAIHKENSKKREGGLREGRHSGKQRDVADKHGEKAKSPVSVHDIVSSEEDETEYTLIHALLYDMKSERKAQLKREKIARKAKEAWERAVKKDYSNTEKKPSRKRTSPHKRSICSSQIFKSSSEKSCSSDTNIRENSMSPLSDWETTPALSMPKKHIVRHSRNGACTPMNYGAVLTMAKQNLEKKIKPKITTLTKMKIIEEPETVSPEEMEREEIEKADVFSDCLKVGGELLSQSALVGDRAVSPPASKTRPIPSSGSIRNLLKPLPCSEPVCCKDSYSGKTAPQICRKLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3M9</accession>
    <name>A0ABM0K3M9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase 47</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin thioesterase 47</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-specific-processing protease 47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101861467</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005108001.1">
        <property type="nucleotide sequence ID" value="XM_005107944.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861467"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045578">
        <property type="entry name" value="USP47_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF702">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25985">
        <property type="entry name" value="Ubiquitin_USP47_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19718">
        <property type="entry name" value="USP47_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="158"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="907"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="996"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1511"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="996"/>
            <end position="1019"/>
        </location>
    </feature>
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        <location>
            <begin position="1035"/>
            <end position="1047"/>
        </location>
    </feature>
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        <location>
            <begin position="1118"/>
            <end position="1130"/>
        </location>
    </feature>
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        <location>
            <begin position="1154"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1178"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1198"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005108001.1"/>
        </source>
    </evidence>
    <sequence length="1570" mass="174750" checksum="034CFFD3825C4FE6" modified="2025-10-08" version="1">MIESRSSVVAASPVDDDKVLCIIRDFVDSHGGQTGKQSLNLQASLSAQQAAQDIARSCGYKENTVSVHYEQQQGGSDDILLEEQDADVSLRNVCCSGAKRHNFTIHELEGVSPEKLGDAADRSGNVFSGKLSFPGNFSVDLPHSSSSSALIKSETGYLGLVNQAMTCYLNSLLQTLYMTPEFRNALYRWSFKGTSDEAVKSIPYQLQRLFLQLQTSKKRAVETTDLTRSFGWDSSEVWQQHDVQELCRVMFDALEQNWKNTVQANLINQLYQGKMKDYVKCLECGYESARVDAYLDIPLVIRPFGSTETHDTVEKAMNAFVQPETLDGSNQYFCEKCNKKCDAHKGLKFVSFPYLLTLQLKRFDFDYATMHRIKLNDRMTFPERLDLNPFVTADEDGLSPLTSGQVDSSDEGIDEGIEVETGCSAASSSSDSSSVSSEAAANNARNSFCSDYKGPYEYELFSIMIHSGSAAGGHYYAYVKAFKDGQWFSFNDQQVSEITLDDIRKTYGGSSGRGFYSSAYTSSTSAYMLMYRRIDRTQNAEFIEPEDFPESLKAELRQQKEKEEAERRQREIDKSTCKIKLYCFHPVDQRKMDVRLEIHKDKTLLEATEIARELLGLQTSVPLDCCRLVKYDEYQDSLEKSFEGEEETAVWELLGGVKANYTFDLLLETKKPEQVFLEYKPGGVTVKVHVVDIHRGVIQPPISVRAYHVQTVQEFKLILQQILGYPAANMRCVLERFHNELRPLSELQKTLKAEGFYKSHKLFVECSGDVKDSSVPYVQSQLCHLLDQYQHTIRITCTLPSRKSLEEYISSLKESPSKAGHSRLDVSSILPLYRHADSSQVDEGISENDSAFYSGGTNSKHSLSGVDPGSNFSISSSTTTETRYGVGASVSASEGVQAAFDTDQESGYFKSTTPRFTSDCEESQSSSGIGEEAGGSGGGGRQHSVVSLPHSSSHEHLTVDMVNLYSKFSSVGLHSSHSDPSIYHSCADNSDSSLQCLGSGPSSGSQEDTSTSAEFNFSCSGPDPEPVLSSPEDGYGFEEDNDEDEGVSIETALSSSTPLPPGGARRPDAVTRGLDLPPSGFSDNYNQFQFPAPSYDDSDDWDRELAKERTACGGTLHSFPSSSSLPQTTGAAEACDPGSEPQAGTEAAAARSETCVSNASAQAAPSTLTQSNTSDAAHPPPLPPPPPPPPPIPPQFLAGSSSLTPRAKSSAQQASVKHCEEEEEVLEVKRYFHAVISDSCETEDRILDVSVDKRITLGAFKRELEPYVGVMSNFFKVYRVYSNNQEFESVRLSDTLSFFEDGKFNIKLGRALQPGEHRVKVYRLCVNEAEPCKYLIETIFAKGMTVLQSKKIILEEVKEQCGLDIPLDRCRLRKKSWTNPGTVYLDSHMYENEIPIYPNWEIFLEVLEGPEELTDSSQLAVYVRHWRPSTHQIDPFQEVVLTHKSVEELKNKISAISNIPAENVEFSKGKGTFPCEVSVLEINNLEWNPHVTSLNMWPLYICDDGHVIYFRDNSEELVELSEEKKKEIQQKENKVSRQTHRISCSPRKERALKIYTDEDDQPSKTSLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K575</accession>
    <name>A0ABM0K575_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tumor protein p53-inducible protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">p53-induced gene 11 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101845429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005109031.1">
        <property type="nucleotide sequence ID" value="XM_005108974.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828448.1">
        <property type="nucleotide sequence ID" value="XM_035972555.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845429"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028266">
        <property type="entry name" value="TP53I11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31584">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31584:SF1">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14936">
        <property type="entry name" value="p53-inducible11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005109031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035828448.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21889" checksum="2390ABC0E3421124" modified="2025-10-08" version="1">MLAEDEQKEGLNKDKMSEEAVSSQQKEPPNMVNQFLKLLLRKHSSGDLHSRLKTRKLLGVGETDDGDIHRSKLSQILGHSDQLYVKLPAGLRVWQVFVALMFTVIGLWALILPSHIFHTTLETPGVELITLPIRLYGGALLSLSIVYWMTLSSQDRDIIRMSLLTCVVYFIIQLVGKKVLLCLFRCTIRDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5M4</accession>
    <name>A0ABM0K5M4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box only protein 36 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109289.1">
        <property type="nucleotide sequence ID" value="XM_005109232.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864022"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109289.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25440" checksum="48A85ACC3EC7FEDE" modified="2025-10-08" version="1">MASLWEQKCQPWLSEDGSIYSKTDTAPAPSKDFVQIYITPNEIYFRQWKIIPPTRADANQQPVEMKCTYEEFPDDDGLRESISRNLGEREVSYVDRLIAGQIDYPNRLPRKILLRIMFNLDLTSIAKLSQVNKQFRELGGCDALWSKIYMEHTTQPVTQELLMLTDQKGWKEVFFMNKLQLQRNLRRQDPKPPKEKRFTFGEKFGKGGSSSRLPEKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5N9</accession>
    <name>A0ABM0K5N9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101853126 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109325.1">
        <property type="nucleotide sequence ID" value="XM_005109268.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853126"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051149">
        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123:SF13">
        <property type="entry name" value="BICAUDAL D-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109325.1"/>
        </source>
    </evidence>
    <sequence length="865" mass="96125" checksum="6CA79299C89CD184" modified="2025-10-08" version="1">MAESVNKEVKEPSSMEDSSAGYETSEGECLEEETSDVYAQLAHKERDLILAAELGKALLDSNQELQTRYDQMVEDFSRKIEILQQEKYDLHLELEKAGTQHQNTVKDLQDDVASLRKQLRNSDQIESSERERSRSLREAQQNTDYLMEQMRQVSAKEEELQKELSRQKEQNETSVATIQDQIDHIAMLREQVEYLSEKLREANQKMIDMEGERDSLTNALEAAHEKLQALELELASRDEQILKQNHEVEELQESNSELQEQLRRRNQIQYHYSPYPNIAFTQGHGNVRSFDRPAAQANHNDLSKNQRNSQNVPSLISQNLPPEPATFHGGHQKTKGSPEDIECSNTSPPSDPSAENSNVDQRMNEKSLLAEFNDSCPELGNDESPPLLSHLSIATESSLPLRHRRNISDGSISSMTEGSRKRHHQNIGGDSDDEDVNRAGDKTGPSSGCKQTLYSKSITKHQMPQKMVSEKSRVILSSYSENNSEVCQPAVKKEKDQTLSSVAISQEENLCKALIASEEAATVLVVGPPLSSGPTFQVKDVIQRSLSLPTDEFSEPDGECGMITSPDSNEKSLLSELSSHILDSGSYSSCPPEQSLFSELSSQLMEDKNGGSCSDSSSTCMMGVFDFSSGQEGHDNEQGSEDLFTDSHSGRPTRHEMDVWHNTTCVAADLLDEDDFECDDDDFLVGNLAGTTLSIGDSGHRTLHYQYHCYGVEEAETDSRTDALYRDDASSKWKAMRQPGARDSQQEKISLACVQLRELVQKVQGHPAPSPQPAAATKGPEAVTPDDLLDLIEQMRLCIDRMPVMQADSAEQQGTTSCNAQSISGEEGSAKGQERGVGQDVQISQKSAQMRKSKSSSSLHLRMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5R0</accession>
    <name>A0ABM0K5R0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sodium/bile acid cotransporter 7 isoform X5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109358.1">
        <property type="nucleotide sequence ID" value="XM_005109301.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860369"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046732083" evidence="3">
        <location>
            <begin position="27"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109358.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="37835" checksum="386640E95EAC3BEF" modified="2025-10-08" version="1">MKNNHFCCGILIVILFAKLFPSIGNAGGILKPEITVKYIAVSVIFLNSGLTLPTEELKTAIFQWQLHLLVQGFTFVVFPLIVYGLVSVLQYTFLHPALLEGMTILSTMPPPVSSAIILTKSVGGNEAAAVFNSAFGSMLGIFVTPSLILLLLGSSNVQVPTQKIFQQLFTTVVLPLIIGQIIRNSQYRWLQRQRIPFRTIGHVLILFIIYTTFCATFSRTDIQMDTLSLLSTIVLIFCLQLSFMCFLLLFSSHSMFSFTSNDSVTITYCGTHKSLTLGIPVIEIIFEGDPNISFLSVPLLVYNPMQIVLGGMSISLFRQWLIDQKTKRRKPPFHWYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K781</accession>
    <name>A0ABM0K781_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulator of nonsense transcripts 3B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101860700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110381.1">
        <property type="nucleotide sequence ID" value="XM_005110324.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860700"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="29"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110381.1"/>
        </source>
    </evidence>
    <sequence length="662" mass="75887" checksum="E8C9B48AF6724205" modified="2025-10-08" version="1">MAQGKDSKIQQDVKPTANTDKKKEKDHTPSKVVIRRLPPSLTPEDFLNHVSPLPDYDFFYFVRADMSLGSNAFTRAYINFLTPDDIFIFRDKFDGYVFLDSKGGEFPAVVEFAPFQKVPKKKQKKVDLKNGIIEQDGDYKKFVESLAQPVENAAVSLDAMVVEVETREAMAGKNGGAKHTTPLLDFLKKRREERKYNIAKLKEERRRGSARDREADRKRSSKDESEKRRAEKERLRDRDRDRDRDRDRDRRRDRNKDRLRDRDKDRKRERDPPKSDKYKEDRNGEKKSSKEGEGAARQPVVLLKNTDRETQKGEKEGEVESKTEGGKKIAEREKEGRPGRVESGREVREWKNEENRGKRPGDKWSDDRRRDGEKDRPRSVKDKERGNEERDRGKGRKDWGDHGGRGYRDEEDRKRQDRDRTRFREDRGERGGSDRYHEKERGGGNLGNKDKGDRGGYGAREKYRDERGGGGGRNRDDRKGGGDGWKKKDVETDRRKYEKERPAEKGRPESGRQQRGGKDDGRLDNKKEREAGSSSGKDTGAKDVPREEKDRQKDSERSFRGPSSTGEGKSSRVKGEVDSQSEKGGGTPDTPPVARHGKEEGGRGGGDTQGGDSGAEVEDRKRKRKERPERQIYIPRKALERQKQGSPQVADTPKDKASGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7K2</accession>
    <name>A0ABM0K7K2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101863937</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110632.1">
        <property type="nucleotide sequence ID" value="XM_005110575.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863937"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110632.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13864" checksum="23C638CB4D1657DA" modified="2025-10-08" version="1">MPALYNKSQDNIYVRRLYRCECLHCTTSQDNIYVRRPYRCECLHCTTSQDNIYVRRPYRCECLHCTSLRTISTCGVRSTRRFLSGKTCHHESSKEEEGALSEMTDGGQDDGQRHHSHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8F1</accession>
    <name>A0ABM0K8F1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4 8">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101862539</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4 8"/>
    <dbReference type="RefSeq" id="XP_005111262.1">
        <property type="nucleotide sequence ID" value="XM_005111205.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862539"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="12">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="13">
        <location>
            <begin position="176"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="11">
        <location>
            <begin position="338"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005111262.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="46867" checksum="BC295D3C56C6DFEF" modified="2025-10-08" version="1">MASPARVFSLKCAVQQYAWGKLGKESAVAQLKAGADPSFTIDENAKYAELWMGTHPNCPSMVSIPGQEEITLQKWVEKHPEQLGPEVRSYFHDSLPFLFKVLSVRTALSIQAHPNKVHAELLHKNHPDLYKDPNHKPEMAIALTPFVGLCGFRPIKEVAQFLQDVDEFREAVGTRAGKLISASHSMDMPLQREAMKDCFMALMEQEEKVVKSSLAGLVNKVKTLQNNPAELKRFEGEVLLKLDSEFPGDRGCFAIYFLNIVRLEPGEAMFLEANLPHAYLSGDCMECMACSDNVVRAGLTPKYIDVRTLCEMLDYTGRPVSRTKFLGIESHGNVDITIFNPPVPDFGVSKFEVPEGTASFQLQSFESASICIVIRGEGEASSESLSSPLKVRPGSVFFVACETSVDVSVSGGSGMLLFRAYSGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8V4</accession>
    <name>A0ABM0K8V4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Tctex1 domain-containing protein 1-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101857216</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111590.1">
        <property type="nucleotide sequence ID" value="XM_005111533.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005111591.1">
        <property type="nucleotide sequence ID" value="XM_005111534.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857216"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21458">
        <property type="entry name" value="DLC-like_TCTEX1D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005111591.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20812" checksum="59B88AD99AAEFEBC" modified="2025-10-08" version="1">MSDRDVARDKAARLLKKQGSVSSFTSSEAAKHDRAQKVGHLSNRSVSSVSFMDEPGHDDHYHAPVKFENTYQLEPAKRFPYATVRSIIKESMENLLSEEQYRPDFCRDMSKTLSDTIKARVKSLMIPRYKIICLVQIGELKAQGMRVGSRCLWDEANDTFSSHEFRNKSIYAVASVYGVYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9D7</accession>
    <name>A0ABM0K9D7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101861480</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112011.2">
        <property type="nucleotide sequence ID" value="XM_005111954.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861480"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057208">
        <property type="entry name" value="DUF7886"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47915">
        <property type="entry name" value="SI:DKEY-19B23.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47915:SF1">
        <property type="entry name" value="SI:DKEY-19B23.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25377">
        <property type="entry name" value="DUF7886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7886" evidence="2">
        <location>
            <begin position="112"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112011.2"/>
        </source>
    </evidence>
    <sequence length="352" mass="39211" checksum="06859B160F35C9B8" modified="2025-10-08" version="1">MEVSNQEAFLKKKLQNFLHELQRIGTVGGFKHFSCYVRGREELVVSINNTLEASSYSCNLSGPPSRKQSVCYSDSFTSAQLPYDKRSLVLSHNSQLGLSGLQEKGVGLPPASPSEQEGTPDRETTLFLIAGYARYSCPYVWVRSNHERLFKLSGDTDRDRDSPLKLKSTARWKDGDVHVIDLLAEMVKLCTYPAPRNPFEVDLDYFRNLAQPHSTLASAAMVSCLQKVVIGTSAAKPYAGKVFEDLHHMAKLHFSGLQDLVKSGKLPVLQQQQKPQQQQKPQVQRQTSRSKRHPPASQQHPHYQPQVPPPSQQSPMSVYLTSPVNTSGVKYGQGPRGAFPGGFERMPAPSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9E6</accession>
    <name>A0ABM0K9E6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-deoxypentalenic acid 11-beta-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101847922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112039.2">
        <property type="nucleotide sequence ID" value="XM_005111982.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847922"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005112039.2"/>
        </source>
    </evidence>
    <sequence length="328" mass="37217" checksum="1E5FB0A66F26AEA6" modified="2025-10-08" version="1">MAADDTGRTVKLGRRAVQFPSAELQVLEDCNHLLGDLAALKRELQEKGYLFIRGFHDQEEVLAARQAVLEHIDSFGSTLNKQHPIREGVLRDGCGLGCVPLMEGKNDITHSELVLRVLEGKRPLKFFREFFKDEVKTFDYKWLRAMHHEGFTGVHVDNVYMSRGSADLLTLWTPMGDVTVEMGVLAVCEGSHRLPGFQKFQEKYGNMDAEKENLQGTGWFTEDPYEITSKFGGQWKTVDFSAGDVLIFGMRTAHMSTTNTTHLARISCDTRWQPASEPVDPRFCGLIRVSDSKFGLLSKMTKEEKEEDRLRKERNTVSIEQLKAVWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAQ1</accession>
    <name>A0ABM0KAQ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101855465</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101855465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113026.1">
        <property type="nucleotide sequence ID" value="XM_005112969.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855465"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35841">
        <property type="entry name" value="PHOSPHONATES-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35841:SF1">
        <property type="entry name" value="PHOSPHONATES-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12974">
        <property type="entry name" value="Phosphonate-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005113026.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31593" checksum="28B03B331A7783F4" modified="2025-10-08" version="1">MTSTDNSGRLRMLTYMCPDVPLEVFTLLRDCVEEATGLEVDLMVEDRFNGPRQDRANPFSSDLADIVYVHSSSYLSLRAAQQENMELCPVAPVCTHPLVNQQPVYFSEVIIHAGNKEKYKEVKDLKGCSWAYNDERSLSGNLIVLDFLKKNFSTNASFFGSIVESGSHLNSIKKVLEHSVIGAAVDSTVLAGYLQDHQEHRDKIVSLKSLGPLPIFPALFNSRLSGATKQKIVDKFLSLSGSATWSERLAGLGISGFAQVDSNLYSLEEDVAEYTQGMKMNTAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB64</accession>
    <name>A0ABM0KB64_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113387.1">
        <property type="nucleotide sequence ID" value="XM_005113330.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849521"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113387.1"/>
        </source>
    </evidence>
    <sequence length="929" mass="100209" checksum="CFDF4CBD13FFA03D" modified="2025-10-08" version="1">MAEIRIPRDRIPHDILLRLQAIGQSVMFPVTGSPPPTQPASQSAVTSSATNYSVSTAPLFTNTSAAAAVWASSTPTATAAATTAVPGVAQCSSSSSPSSSSSSSSSFPSLHSSSLQFNPVSIPVATTACPAQIHIDTRVSLSPDNMSSTSLSPSLQSPRLSVMPSSMSSSPSLSHTPPPPPQPSSSLPFNSLASSPKIYPTAESTPLSHQTQSSASITHHQKSNSGKKSPTRHMTSETRHMTSKPRQLTSEPRAMTSEADLRQQTIDETDGADPGSIVHVLSEHPNSKRHKPEVDDSDIVRVFPLADEHDSEEVDSSQRYPVDDDSGIVRIFPESYSDVKRQQGSSPFRENDTGGCTAEESNMVNVFSPSKRADSQSGVPSCTNARAGSKTDICASEMPAASTVRYLPPPQHSFTSPAAFNNSRSHHAPSHLSRPNSSGLHFPSNHASRTSPTPPSLSHSPSANQTPSRHSRASPQTTQKLLDAQDFSSGNNRHGQQTVPKDIITPAAGRKLGHFRHSSALSVCAAARRSPEIPTPPQTPDDAEDDEVFSYDVVSVADDGFSSRRLGVDAFRLSQESTPQKESHAPLRHNSDSRSYESRHAHGFRTSPFSPAQKMSELNVGDRQHTRKRLSFEEEDLATPLSSSQTIQYHSDSALANHSSQYFHACNTFAPQIFASQGQLLRLPNMPINSLANQRNCPQSPSPCMSQAPPSSVQNAPLASTSVLQSHTPTKCEPLAPPPSPFRPTSVNPSSIPEVKDIIERLSSPGQMLPRSRLHSDGDREAESQMHTFGGSPVYGRGSPVLAPPRARGQTFSHGKRRRLDHCDEHDGPSPTFGSAHSQSIPRPESTEAKRETCACATIERNFLQMAEGAYKNIRRMDSTVADFDRFRQELAQTNTILRESFAIIENFKSICEHKGVSSMSSDNVHQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUF5</accession>
    <name>A0ABM0ZUF5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101856080</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101856080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934693.1">
        <property type="nucleotide sequence ID" value="XM_013079239.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856080"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012934693.1"/>
        </source>
    </evidence>
    <sequence length="738" mass="81256" checksum="6A80F901248D50FE" modified="2025-10-08" version="1">MVYSEVQSVLEPYEASLLLLLGFGGLSVCLALLYNFIRRRVFADANNLDRTFDAGGNVSMSLTAVTVAVQLLWPADLLQSSSVAAKYGIAGGFWYSTSVVVNIILFPLLSITFKTRAPGAKTYLQVFQARFGKAAHLVYCVFALLTNLVIISVLLIAGHALFKSLVADISDELILLIFATLFGSYSFVGGLGSTFYVSYANAVVTFIVLCIYVIKFFYQADEADLPFGTIEDVYNKVIVLEGPADNEENNFLTFWSADSMVWAVQGVFVAASVTFCDQASWQSRIAAKPMQGVLGFFFATFIWFAIPATLGTTSGIVYLAYSSGGNNTLALSDDDINAGLVTPYIAQAALGRGGGIMILIMFTMLMMATGSGEVMGVSSIIVYDICRIYIYPFKKNLKDGHCILCDQTKKGENHNTEEGKPYIVNDHQHNVGHQEHEQYCTCPSVVDCADCQADNDRAQQASHSSTLTPQVHRCPVHGQYRMYQDMLVRLKSWVMLWVTILVVPWGLVVVRSGIDLNWIFMTGCIITIQAFPGVVLAIVWVKTTGVALVIGGLVGLVSGVITCLARASTLEGGLSDFLLNTSEGYSVMAGSCVTFFVSLVLDVVISFCTHRIKSETDADQEWQKLRDIDNPLSPWREIYKEEFPHLNSQQRPSFKQLDSCFRKAKLTAIIGTVGCLLLFVIIIPGAMASLHVLTSSEFKAFLMILQIWTFVMACIVIVLVPVEEIWTIVKQMRKRTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVS7</accession>
    <name>A0ABM0ZVS7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sortilin-related receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Low-density lipoprotein receptor relative with 11 ligand-binding repeats</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Sorting protein-related receptor containing LDLR class A repeats</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">LOC101857914</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endosome</location>
            <location evidence="7">Multivesicular body membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">trans-Golgi network membrane</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Recycling endosome membrane</location>
            <topology evidence="6">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the VPS10-related sortilin family. SORL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935564.1">
        <property type="nucleotide sequence ID" value="XM_013080110.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857914"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="19 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0967">Endosome</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="20 30" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="27" id="KW-0732">Signal</keyword>
    <keyword evidence="26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046685798" description="Sortilin-related receptor" evidence="27">
        <location>
            <begin position="31"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="2190"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="1678"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="1788"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="1983"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1134"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1141"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1153"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1173"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1180"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1214"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1221"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1233"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1254"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1261"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1273"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1314"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1346"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1358"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1422"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1464"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00029896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00032450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_012935564.1"/>
        </source>
    </evidence>
    <sequence length="2262" mass="252957" checksum="25979D99458F4063" modified="2025-10-08" version="1">MAQPVLRDSGHRILFLHCVFCLVLFPSVQTAVEATKINEHGFSTFRHKTLHFPPAENERNSNFLTVSVSQEFQLSGSKIEKIFYADLPGLARKKRSTGSDDVDPLHLTTKADLDDAHSTIVVHWVGSGRDEIFALAKDVNGLSSALFISKDYGKHFTDVSDQLMVNASVKGVIDSYYDVNAFNYMYMFADVKHDCVFTSVDTGSTFETFCHLPFKPRTIKLYPSNPNYVLAMDDEDPLGRLYSSIDFGRSWELAFSHVKSFHWSESSHDQELTVYMEKEVGGHLKEIVRCSRTDEGWLASEVLLSNVVDFEMRDEYLFATKSVRLLGLKSNPNLQLWVSHNRGSFMKAQFPVSFNITDFYVADTSEGQVMVCVSHNSSYTNLYISEVNGYRFSLSLEKIVFFNPRSENPLGLIRFYTNKTFADIKKLSGVEGVYLASQQIGDELDVDTQRTLVTFDKGGRWQPIPPPEEVLSKNRNRCSARNAHGIRTGQLNNCSLHLTQEFHRLYPTSQTSTILSKDSAPGLVIASGMLGTSLNADADVFVSSDAGFKWRMVLSGNYFYNFGDHGGVIIAAHQFIPTNEIIYSIDEGATWQQYRFLHEQIRVYGILTEPGEKTTTFSIFGSQTSHHSWIILQIDFRDIFKNKSCSPNDYKMWSASYDLMKEGCLMGHLTEYQRKIANAACYNGQGFVREVQKKNCSCTREDFECDYGFKESVFGLTCSLDPSVPASQIHQIPTSCHPGSFYESTRGYRKVSGDTCQGGEAHKFAPLLYSCPVRETPEFFLMTREESISVVDIASLSVRDLVHGPDIGNLSVFSLTDNCLFYVSRRNRVKKICFSHNSTVDSEDSLHGDLGEGVLTGMDYDWTARVLYLTSAAGNEVRVLHSVNSFTKTIYDSSNGVFQPRRILVDPHHGYLFFVGAMSAGSSDFGIFRAVMDGSDSKVQLLANSSVVSQATTMAFDLSVEKLYWVTPEKRSIFSMDMNGDKNEVSKVYSNWFLNSASGIAVYKQRDFYISCSDTTSLRRVKETWRGWEDVVPDVNFVASMRLVSNTSQHAVSACNEFHMRCSQLCLPRPTPNPSASTHHQNRTCACGDGYRKSLQPSAAPGGKGPQDETCLCGNGETMIEDGTCVTAENITTCATDHLRCRNGHCVLALWKCDGDDDCGDFSDEIDCPLRSCGSDSFTCRTGRCIPFSWKCDREDDCRDGSATDEQNCENQTCSSEQMRCNNGYCVSKRFRCDKDDDCLDGTDEENCSYNTTCYSWEFQCANLQCVDSWFHCNGHPDCDDGSDETDCDPPSNCTNTQFACETGDQCIFNSFHCDGNSDCQDGSDEKDCEMTPTETTSPQTCQFRCRNSFCIAYHDVCNGFDDCGDNSDEVYCSDVVYPTQDVISPTTPTMPSPEVSCDNNHFLCREGPGFVRHCIHRSWLCDGDRDCYSGEDEAHCQTHNVTTAPGDVYCQNSGRVISMGQFCDQNVDCSDGSDELGCEYTGHVDCSHFNDHKDICCSTKQCQVYSQRHGSIFLSSGRCRSKNSYHRGDRNSCEGVTPHEPETSQVCGAQQFECRGYWTCISFVQVCDLKMDCPDRMDERQNCGCKIHNSFQKPVTGLVTNSSISWVFPPYVTSIAYSMVESEVPLANLTWVQVNVSNTHLDVVDLVPYTAYRFVFFEDKCALYNLYERTEEGVPAAPENLKVRVHNEYNLLGVDVLWQRPSVSRGEILRYNVYYQEMAPDGTSVGDVQEKLVPASAMRTNHRDFKTVVVDGIHNGRKYDFWVAAVNHKGIGKSSSKVNITVSDKIPLSDLKVKVAKLTDSFVNLTWVKDNKATGFKVTVHMEERGSRVVSLEKTVTWHKVDKLCPGSSVQLEVQAVYPKGVVGRPNYPRTSQGGGWLVMQGVAPVVHIESVNMTGSTSAIVHYHQQAGTIPQHYNIYYSTRAVGRESLVEPHVFKTSASHSFELHGLLACESYFVAVQPDLGSCPLSDFKRLVTQEDESAAPKHLKGQLKKFERSYSVTLTWSAPCSHVPVPVRYLLQIKMGSSSANNFVTPKATNESHLSYVVKQVVSGETYRFTVRTYVAGSQESHPLTMTIPELGAISDVQFAVTGVDSLSIFWIWPQKDTQNFKEYIVSTVDQSRIFSWANHTSESHIDLSDLPVDRVFNIHVKAMSKEDTVLAESHTKEFSFLSQPGASRQDDDSVSIKKTNLVAILVPVGVVVVLLSAGLVVFIVRHKRLQRSFLAFANSHYNIQSGTTTFSDDLDGDEPLIQGFSDDEPLVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWR1</accession>
    <name>A0ABM0ZWR1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integumentary mucin C.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936091.1">
        <property type="nucleotide sequence ID" value="XM_013080637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859695"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047321145" evidence="2">
        <location>
            <begin position="20"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012936091.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="54915" checksum="1D503E85936CC367" modified="2025-10-08" version="1">MRLRQLLLPILLCLSAASAHDPRCCAQIDECETNEANDECVCGSLKSSLSCRLFVVKSGVQRATRAIVDTLRSRLDLNQIVRAKPVAFYSHSIHKRQASFSAQASCCDGSNIIATTLGCVIVAGECKCPASAQASLPECSAAAPTTAPPTAAPTTAAPTAAPTTAAPTTAAPTVPPTTAPPTTAPTAAPTTAAPTTTAPTTAAPTTAAPTTAAPTTAAPTTAAPTTAAPTAAPPAATTTASSRKGSTFIGKTSCCDPSQNFRDYATGMAYCSLEGGDCVCQNVPEASECLQPPIPDGYVSSLSSCCDPTPPTLDQLIAKLQGQCIIQAFTKRCVCRSFVQSTCGLPATTGAPTTPGSTTPTTTTTPATTTPEPTTTPVPTFYQTVPACCDPTNTPDYFIARTLGCVLNDGKCMCREDQAPTQCAPYSGPTPYKGSRECCDLLYAINSQKPTTYFMVQNQGCRPPVPDDGKTCDCPDPADLALQGKTVLTTCPKVVETTTTTTTPVPTTTTTTTPEPTTTTTTTPEPTTTTTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWU1</accession>
    <name>A0ABM0ZWU1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Pleurin precursor isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC100533448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936133.1">
        <property type="nucleotide sequence ID" value="XM_013080679.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936134.1">
        <property type="nucleotide sequence ID" value="XM_013080680.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100533448"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021885" evidence="1">
        <location>
            <begin position="22"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012936133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012936134.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20264" checksum="68AB1991FE5F9E25" modified="2025-10-08" version="1">MQSHVSSSLLALCVLTGSACAMFYTKGSDSDYPRIGRRSFYTTGNGNHYPRIGRRDSPGAAAGTDILYPNTASGFSDFSAGAPAVKRGIFTQSAYGSYPRVGRRSQVGDDGSQEGLQTARSKIFQKITGLDGPVEEELGDGSAERLEADNQIGLELMFLAFDLDGDQALSKSEFQSGMEKFRRHNPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYA1</accession>
    <name>A0ABM0ZYA1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011528</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937017.1">
        <property type="nucleotide sequence ID" value="XM_013081563.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011528"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937017.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33758" checksum="94D9D4E4C2C76780" modified="2025-10-08" version="1">MADVTESAGENGVEYSSALHACPEGLTLQDARTHSSIPTSDMYELHDLDFDVFTRNVGWRASSRDDGRVNHGFSFGESSFSVGTDDHGADSDHKKEEDDEEEEDARISQAYVTEANAHTPAPSPNFRGRRQVLSHRIASVGSMGHNLALGHITGVLVEDSELKPGAVLPDTLTIALGEDSPLQTDLNWEKPANVHRLTGVSYDVEAKAPDGENDWQLITSVRQPVFRIYHTEETLFLGKCRIARQETDVTVCLRVRARGELSHQGQPSGHMLLGDWSQDIRVIFVGTRPTHNVDVHISEVLDITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYI4</accession>
    <name>A0ABM0ZYI4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859632</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937168.1">
        <property type="nucleotide sequence ID" value="XM_013081714.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859632"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042651">
        <property type="entry name" value="Rgs22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46583">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46583:SF2">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="403"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="644"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="962"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="1336"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937168.1"/>
        </source>
    </evidence>
    <sequence length="1561" mass="176401" checksum="CF675F133364FF90" modified="2025-10-08" version="1">MPGTTMAEINGKYFGDERINPKVLMFPLEITGENLEDLLAYDDLFLDYFNHFLALPVFPQALLYNRLTGAFDEVEGLRPEALGTLPTISPSLQYGPTDAERERMLEWAREERLPLFLRTQLFRELKMAKLLLRPLEFDRQSASRGSSRNLRGYSRATESYISTLSVSGDQSGNDLYDYDDIWGELNYSALYRWQRPGSHALSLPTRVFFGECKSYGLPSSLDSASTHSSERSTIKALSAITSRRFGAASTVQFAEFPEKPEEVPPEDNAVVPVLPSSGKTTETARQRARISNKVEVIPTSKSVVKSQGSKSKSSKSKAPASSTEEAFLRGARVLSAPVNYEQYLKMPRLALHDFEALFGEAEPELGGQAFVQFDEEGISEEQTETDMRNMEGRLKMTVQQVKEKILGSHDGFEEFREFLQGTMGEHLLAFWLDCENYKDTMEDFDDIENMEIRNAHFRDIQDKYKLKLTTDAREQITRAASNMGLSHTIFLRTQYDVLRRLRAYWMPRFLIHCHRTRSDSLEGDETDQVLPSAMPVPPSQSLIDTASLKPARPQNALFPCISLVHSMPVLPEDARDYANRLLVNVAFENSNSSARRMFPRQRSTMSAASRVSTASVKTTISTFRSTKERFLLALAADRLAGGPFQRYLAKLDDPQLLASLLFWEDVTEYGATEDRSSDRLLRLCHAWNIYNKYLSLDSPHRIDLPEKERTRLQRHLEKAREMLEASIFDRAKTEAVEKLERAWVRYLKEDLKTFLDCRVKAGAESPPSTADAIEITVTEYDVVIKRPRPWVRRLQPLRYSRKRNPCSLLRFPCGFVLTHSCVPYWCATRHPFVFSFSTSFAALAAQIGHISVENRCIDCQSSIHRKVPGSTSSERARRLDRALNTAGEVDEERRAQKRAEALARRKAMERERRKAIRAAQARQKEARRKKTSGGSAQDKLDEELPEGEEGENAGERQDKVPSFADLSGNRQIMSMFRKFVSEAENKDVHSSIQLYSDIETYFSTKESKVKKDAAAATIYKTYLDPQGKRHTTLPEKVAARVAQEKDRPKTPLLREIQRSVLPRVEEIFKDFITKQAEEFNMDPRDLATMSQSELAMRMGNDQAMMSGWNKRKSRGKEDKTDRDGKDKDKEKKESKDKEKNSQDKVRELEFSSVRVSVLEGGQTGKFAKTKPLPPIGNGPDATRAGSGTSESNTSSADVTSSGKSRGRGRRSKASRRRVLFGTISEADEMSAGDGGSSRLGRGRQDQLTFDLSASEGGALLATPPGDPLSLPLQQAPPPRPASVLSTRSYSRASFITVTKRGRKKTTGRAQATREDKNEFLAALGLSASGHPTLSMLYFYKYLMKHGEEDGMPQIDKDLFFYIEVQKFKDGSHAFSDEEMLKRKVQSIVDCFLESVYTPTLQVDIPSDLHQRTLKAAQRYLGGKEVVPTLFDEAQFHVFKELLFYWAGYKRATSTPDEAKKRPVTKYDKMLRRRMENIVNYQVPSSDFLLPSIPEGAIPSFTISLSEGVKFKDYRGELEESFAGTPLPDTSQKEHRGSKATIAGDVARRSRGRSRSNSVIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1S0</accession>
    <name>A0ABM1A1S0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stress response protein NST1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939068.2">
        <property type="nucleotide sequence ID" value="XM_013083614.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863030"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939068.2"/>
        </source>
    </evidence>
    <sequence length="539" mass="62429" checksum="60136692FE9D376A" modified="2025-10-08" version="1">MALWKETDKTVEQNLLSERDRQRQIARDRIEALKKQRADKNKGKTPATDDEPGVSSDITNETVFLQDSILAGMEKHQGDERDMLMTLVSKYEHNKDKGKQFAKMSDEDVKLQLLKLEQNYAEWEKKVSKSIADVNLSNLPPKKKLKIQMESQKRQKEQAAILEQALSHKFELELRQLKVQHPDISQSEAHNELSICALADLQEKQMRQVESTQDSIKNQAEDQLKEMRKMQRAVNSEGWYKTLASTLFSVSLMMGELHTEEDMEKKLMEEFEQQKKELLERGGFTRKAGQREAIDVDAMLKELEDQYNSRKQALSSDLQRQREMFKQRLALKKQSNEDKEWNAAAMVGQIVAATQANDSAAKLAREGQRGKQDNLLQQKLQARREARRQAAEEAADTLDSPMSRESSLMGQASDRSRSPRQTPTFSLTREKTVVDVRVSDEQKQEMYDQVVQQGLKRQQQIFAEQSRQEELLKRKLELRSSKRENEAAALYSLGERQKTVLQQSQRDERERQLAQMKERVSKMRESRSKSPRGGSMKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A280</accession>
    <name>A0ABM1A280_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coadhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939340.2">
        <property type="nucleotide sequence ID" value="XM_013083886.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852417"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939340.2"/>
        </source>
    </evidence>
    <sequence length="269" mass="29227" checksum="817D8C1C602E6FAE" modified="2025-10-08" version="1">MVKCPVHGGWSLWSSYTLCSTTCGRGVRERSRSCDSPRPQYGGDKCDGPANQKQQCYGGKPCPVDGGWSSWTNFGYCRAPRCGRGYQIRSRSCSKPRPAHGGKPCPGQQYERIACHNDHDCPKNGSWCGWSQWNQCSSSCREDAPLQARQRICACPAPRNGGAECQGDSFQVQDCEGVPVCNPEEMSEEVEGASGGGDTDDEETEAETSSNSSSTKNSSSGETETTSKSMEDTRQAAEQVTQEYSAVTSEYSETERDEVDNTTTTVVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A297</accession>
    <name>A0ABM1A297_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurofibromin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939367.1">
        <property type="nucleotide sequence ID" value="XM_013083913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012108"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13313">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="41"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939367.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="53552" checksum="A0ACCC29956C74E5" modified="2025-10-08" version="1">MATLLAYLGPPEHRPLDSQWSSMDMTSTKFEEIMSKHNMHEKDEFKSLKNLHIFYQAGTSKMGNPVFYYVARRYKVGEINGDLLIYHVLLTLKPFYNKPFELFIDFTHTCSENRFRTDFLNKWFVVMPENVYQNITAAYIYNCNSWVREYTKYHDRILSSLKNNRKLIFIDHPAKLSEHIEPDNQKLPGTTMSLEEDLKVFNNALKLSHKDTKVAIKVGPSAIQVTSSEKSRVLGHQVLLNDVYYAAEIEEVCLVDDNQFTLTIANESGPLSFIHNDCDNIVQAIIHIRTRWELSQPDTVTVHTKIRPKDVPGTLLNVALLNLGSSDPSLRSAAYNLLCALTQTFDLKIEGQLLETNGLCIPANNTIFIKSISEKLSTKEPHLTLEFLEECIQGFGNSNIEMKHLCLEYITPWLPNLTRFCKQSDENKRQKVALILDKLITMTIEEVEMYPSIQAKIWGNIRHIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A301</accession>
    <name>A0ABM1A301_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012193 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939796.1">
        <property type="nucleotide sequence ID" value="XM_013084342.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012193"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012939796.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18610" checksum="6017DA4A42ECB44C" modified="2025-10-08" version="1">MSFSPRGAAKRPPGSSALPYPALPVCCVNSERRCGAIPFLYPVVDPPWYDCPPKCPRVRKPLIPRAKFHHDLVYNHFQEYISPEHEDLVMPIMAFWHYCDHVPDLDPYHSGQQFRRSRASVTGNPVGPWPPLAQGVCPPSRDCQPCGPGPWANPQIRRFFFTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A345</accession>
    <name>A0ABM1A345_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012208</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939860.1">
        <property type="nucleotide sequence ID" value="XM_013084406.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012208"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939860.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33037" checksum="77B61003FC416DB7" modified="2025-10-08" version="1">MHRATDDVPTIARLSGTRQCCVLYVIFTMAAVCVVVASTDVTTNPQNGGATGNAFVYDDYRSNSTLQLDIVFICDGTAREYCSADVMMSEINKHFPPPDDLFFSDEDSSFNISDCDVNPQSKCHNFFSNTKNTTSPPNGVRYSLVNNSIVATKLLESDSSSSFFLKLNVTFHVLTGDYPDLLVEINTLAVTASADVIIAVGGAVTLQSSAFVGDALDIPTIGYITNFKDGIKNIYGRTFTSLNPSPEAQGTALAQVIGSFNMKQTTVMVEDTRLADGFLSGVRKVVGDRNQDVFRILPLQRDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A347</accession>
    <name>A0ABM1A347_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850573</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939862.2">
        <property type="nucleotide sequence ID" value="XM_013084408.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850573"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939862.2"/>
        </source>
    </evidence>
    <sequence length="748" mass="83697" checksum="4810772F03C060CA" modified="2025-10-08" version="1">MSVKNEGNLFDTELCASRQKDPQLTSERELSDDEQLAPAQLSVQKTTEGELFDNEPFTLAQRSPKITSEEGLFDDESLSVPARHSPKERSDGDLFDDEQSIPAQHSPKETSDGELFDDEQSIPTQHSLKETCEGKVFDDKHFTIAQQSPKEPNAVESVDHEKCAQCSPKRVNDGEFLKFDNEKYAPQPQLPQQKIIQREFFENEQLVLPLLSKKISANDHGQYRAQLSQKEISHETFEFKEEVSSPYFSTLSVENVTLSNVLAQHSAEKVVPAETLSRNEPQETDYSDVSGFERNLSASGALLTFPSPTNSPSQKVLLQPSVENTPISVISSPLCSVEKVPDKRKNNSQVSSPVESEYKKLKLFTEEDYQVMGLVSTPPVGNGLKEEPVRSQSTGYNCENEKLECVEVYQSPEIVQSNDGDISESDPITPDSIVKTISREFSKFHAPETEIARHQDLIEMKQYESERRSPSDEDAIVVTSKDDGTTERMISQGNDTGIEIQVRHNCQREGTFKLSQMFDSNPKNTGHDAQEPVVDHPDYIGLVQKEKETTSGGDFVPTLGEDVFVETFQKGESDNSVVPQNPDQTSKEIKIHHSDSIEESNVKESEHSYEKTSIESNVKESKHPCKMTSVAGSVSIVVQEEYSEHIVPSSSSNEADPVICSDVSLYCAHEDTATQLNKDPHADHHRVFQWTSTSVQHELKSHDDHGTVPRPSELTPLARLVPSYRSLRVGLSKKQKVAHLHKQGNRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3F1</accession>
    <name>A0ABM1A3F1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-catulin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940031.1">
        <property type="nucleotide sequence ID" value="XM_013084577.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852188"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030045">
        <property type="entry name" value="CTNNAL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342:SF1">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="723"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012940031.1"/>
        </source>
    </evidence>
    <sequence length="787" mass="87002" checksum="4BF544B227398F37" modified="2025-10-08" version="1">MAGLQPKNDAKLTLEIRTKSVEQTLVPLVTQITTLVNHKEKQRISEKAHKALERVGLAVGSAVDRFVSVGQSIAEENPDIKADMCFACHDARSAGSTIQALTTVRQTGEEGMVPPADKTAMVRAARQLLSAITKVLLLADRIVVKQLLLSKDRVLLSLAQVEEVNNFTDFVNAFSQFGKDMVELAHLSGDRQNDLKSDKHRAQMGSARAILEKSTMMLLLSCKTCLRHPDCSSGRHNRQGVFSMIRQSLDLIQHVVTQGGQEEVRPEGGPIVNGDSGIGLASSHPTASRAFSDFEDQVDMTRVTMIGPAVEDRLLSAFESVKETVEEFTDSYYTSHEAREKIVQLSDVLRDDLQSMLLLGQNLNCRDARTPTHDLETAIIKTLESSKILRKQLLCTAMSQASDLFRQNDDEGLLKALRVAGVSGELDRVEELTVKFSEHQEQLEEVCKLFRHMASTEPLVITAEHNESFLHSLGPLILFAAHTLAQHPDSKITRENLEVFSDAWESQINDLSILVKEVNDVCQGRGDKLVYLSLPRPGVQTPPKHGTTSRSLRPAKLDAEEQAKIAKLGLEMKLITSETEAEADKWEEPDNAVVKRAKNMSSMAFSMYLFTRGEGPLRTTHDLFVQAQFFAQEGNKLYATIQHFAQRVPTCPQKEELFMYLDRIPVCCHQLLTTLKSATFGKTATFNKVDSAIQETKNLMNIVAKVVTTCFVCATKFNIDYRSSPTPSTSSQVTRWTSASTSSNPTRYELRSSGSDTESGPGSSGPSEGLYRSTSLNKPLSTLDKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3N1</accession>
    <name>A0ABM1A3N1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein enabled homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940172.2">
        <property type="nucleotide sequence ID" value="XM_013084718.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858789"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940172.2"/>
        </source>
    </evidence>
    <sequence length="191" mass="21502" checksum="67FF550C4045E11D" modified="2025-10-08" version="1">MTPDEYREHRRLQRAESRGRESAQKKRWIREKKRQKIKAKRDAERGMTSHPQAISTPVPPSPQCDGPCPPIQTPPQLGAQALPNAPPSPPAVPGPSTAPDPSTPPRNLARKTLYNIKSKIKKLLRLPTPSESAGLVEGLANPKTPEFKKALRKRNFLKSPQKKARRILFGKKLVFSFTHLIIVCTNFEKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3T3</accession>
    <name>A0ABM1A3T3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein HID1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940253.1">
        <property type="nucleotide sequence ID" value="XM_013084799.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863278"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940253.1"/>
        </source>
    </evidence>
    <sequence length="846" mass="94471" checksum="1A0E00E694F13FFA" modified="2025-10-08" version="1">MGNTDTKLNFRKAVIQLTTKTQPIEANDEAFWEQFWSESVTCVQDVFTLIPAAEIRALREESPSNLATLCYKAVEKLVTAAETGCPSQREQQTVLNCVRLLTRILPYIFEDPDWRGFFWSTLPGQEEEEGDSPPLAQSLITAVCDLLFCPEFTVASSRKSGPDNPEDMGTIDSCEYIWEAGVGFAHSPPHNTVHDQNRTELLKLLLTCFSETMYLPPVADAHVVPNQWIQFFTSTENRHALPLFTSLLNCLCSYDPVGYGLPYNHLMFTDSREPLVEASLQVLCVTMENDCNAQAVSVDGTSGGTAMEQGGEGGGSDNLFLNYLSRIHREEDFAFILKGITRLLNNPLQQTYLPGSTKRIQFYQELLVLFWKMCDINKKFMFFVLKSSDVLDILVPILYNLNDARADQSRVGLMHIGVFILLLLSGERNFGVRLNKPYSVRVPMDIPVFTGTHADFLIIVFHKIMTTGHQRLQPLFDCLLTIIVNVSPYLKTLSMVASTKLLHLLEAFSTPWFLYASATNHHLVFFLLEVFNNIIQYQFDGNANLVYTIIRKRNVFHQLANLPIDHSAIAKAMTKRGRKFAAPPQDTRDPQTMEGAQPALEAEPGTLKVSLAATPRIDKMTEKAAPDDNHRQPTLKELAETPGPQNVQPPNEIQDPVDSDDRNENAAAASGGSGSAQSSPTRSSSKAGAASQQPSVTVSPPATPTTPTSPLTPTSPGAESIGDRSRMLKAGTPGHWVASPEWVQSWKQKLPLQTIMRMLQVLVPQVEKICIDKGLTDETEILKFLQHGTLVGLLPVPHPILIRKYQANSGTTMWFRTYLWGVIYLRNVDPPIWYDTNVKLFEIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4J5</accession>
    <name>A0ABM1A4J5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Gastrula zinc finger protein XlCGF26.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101862286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940711.1">
        <property type="nucleotide sequence ID" value="XM_013085257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862286"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF159">
        <property type="entry name" value="GROWTH FACTOR INDEPENDENT 1 TRANSCRIPTIONAL REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012940711.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49418" checksum="5B8DA4E1FD58B16A" modified="2025-10-08" version="1">MNTTVVRENNAATNLLLSGFTGEVDISSSQLLQSDEKNILSGQTAQLDEEATGISSLAVNTSQRGRGDKNRPFQCDLCGKGFKRRAHLQDHQVRHSKVKAFECDVCHARFGLKHVLQAHQRLHSGEKPFRCEFCGLSFTQHGTLIRHHLTHTGFKRFRCDLCNKRFACKRDMTSHAIRHLGERVYGCDTCGKKYTNPKTLASHKYYVHSAERRYVCDTCGLAFKMKGSLMNHKLLHSGEKRFACDVCDKRFARKKDMQTHRVRHSGLKLFACEVCGKTFSSKSERTVHSKTHTAERLYVCAVCGKDFNQKRNLTKHLQRHTGVKLFQCQQCDKRFAADRDRREHELTHTRDRPHACDICGKTFRQRSHLRGHRLTHSDLRPFVCTVCNKGFTMRWRLTSHQKTHLGGGGGGAGAGGGAGRGAGAGGGAGGQPLAAHNLPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4M9</accession>
    <name>A0ABM1A4M9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940764.1">
        <property type="nucleotide sequence ID" value="XM_013085310.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861967"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028015">
        <property type="entry name" value="CCDC84-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31198:SF1">
        <property type="entry name" value="CENTROSOMAL AT-AC SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31198">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14968">
        <property type="entry name" value="CCDC84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940764.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="58910" checksum="5228048626EDA80A" modified="2025-10-08" version="1">MSSVGSFTQFLYCPLCRISYKKSRKHMYSKRHQEIVLNILKKFSTKIQNAKASVTQPKIRMLTAEDREIFFWCYFCQKDVLVHSFKQSQRGDCVIESGGILEHISGSDHGVCADRFLKENKVELERKQEFVMSSQGYMKFWEAASYACESFVSEKVKALQQITADISGQNLHSQYTLMSATLDKNDGRQSTQGSFVQPGPQQQTRDEATWFDPEAQRKKTERAFGEGLTALDRTQEDDSVGNIYTNALPPWLRADPDADGAATASRKIGPDIGDWDKHKKLKKKSLLRADRTGAKFDRQKEQSDNWLPSFGGVWRHSARTHSVKHFQKRQDLKDPSRPSASSGSLVVRSGLSKSSNSTPTGNPWLIPNCLPTAPSSGSQTESRVNGAVPSSFVSDSGGDGARSVNVRPYVRKQGGCVGSGRSMSDFHASPAEPTGNLASSEESFMDFVGVKPYVRKRRSQNKAAGSVAMNSYPYPTVYGGGEQDRWRRQVSGDHYRPSSSRQQADSTYSKGDREDSSFSLISTPVLHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4R5</accession>
    <name>A0ABM1A4R5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox protein PKNOX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101859344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/MEIS homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940812.1">
        <property type="nucleotide sequence ID" value="XM_013085358.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859344"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="340"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="342"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012940812.1"/>
        </source>
    </evidence>
    <sequence length="696" mass="74401" checksum="01302DD05A85F89C" modified="2025-10-08" version="1">MSIIQQGLPPPYSDPQGMVGVTEASMQQSFLTLASQDSTVPTTIHTELVHPVTDAGENQDAFKQSIYRHPLFPLLALMFEKCESATASPDTASHGFENELQAFAKHHDHLKTPVLGADEEVNELMLKAIQVLRIHLMEVEKVTELCRDFCSRYISCLKSKLTSESLLHVEGCDSPPPGELAGSQGVLNLSPALQVPQPVVAPTVVGGSVVLQQQQQQQQPQQPPQAPQQPQIVSGNTVYQMVHTPQGIVAQPIQIQGPLTPISQAMPQVIHGSTPLSQIGLSLASPQQQQQQQQSQQLQQSQQQAVQTAMTPQLQHVQKEAKSAAKLNNMLQDDIDDDDKNSKQKRGVLPKQATQIMKSWLFQHIVHPYPTEDEKRQIASQTNLTLLQVNNWFINARRRILQPMLEASNPDKAKTKKMNKPTNKPQQRFWPIPLDTSANGVAEKSEKEGSGQGLKIKPEVSASTSSASSASSSASSAQKVGLERLQPVVTMETAAVSQSDAMMGYLSNGGLVLKISPEGHLVPNTQMALPANPAPLSLESLQALQSSGLVFAPGPAPLPLHLPLGSLPHSAAAGLGLGMTPFPTLAAAAAVSPMSIGGLNFGAPAFSAPLQFANLNAAPIDLSTMSTGGHLQMSAMASATPVPQQMNAASGQVLMSVSLQEAGQEAGMEDGESEPEAGELRVDTRDSRPALDMSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5L0</accession>
    <name>A0ABM1A5L0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941268.1">
        <property type="nucleotide sequence ID" value="XM_013085814.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852199"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941268.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18206" checksum="7594AC4B3853EEB1" modified="2025-10-08" version="1">MIDSPLADDDANISDPIPRLQSSNHYSHNYNIYNTNDDDDEDDELSSTAKAALVGCTVVGVMLVAILCSCLRSCTPCSSPCSQLWPTQTTTGTDTTVVDANSSFIVSLSETGCELKERDMRPSFSEATSALASDITSCGGRRSVDKRRVSAGENAEEHDVMKDWWGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A655</accession>
    <name>A0ABM1A655_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101851663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101851663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941571.1">
        <property type="nucleotide sequence ID" value="XM_013086117.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851663"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="4">
        <location>
            <begin position="410"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012941571.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="67890" checksum="168AF93CE12DF81F" modified="2025-10-08" version="1">MFTNKTRQWRQTRPDLAHLHILPLKGVILLFIRVAFVVVSATGISEGNSHHTPAEKIHILRADKSQTARSSYNPFEIKSKSRVISPVVTRKMEKEPGDKVGDSENVDAIETPGGPTCSVDKMGNDVDCRDKSKTVDSEKVDTETPSDPACSVDKTGNDVDCPDKSETRDSEKVDTKTPSGPTCSFDKTGNEVDCPDKSETRDSEKVDTKTPSGPTCSFDKTGNDVDCPDKSETRDSEKVDTKTPSGPTCSFDKTGNEVDCPDKSETRDSENVDTVSETTSGLTCSLDKAVTDMDWQDEFEAESVQNQYGGPTIKYSLGDFNTDSEEDCDTETDEMASKDDKSDEYKREPAGKKYKQTTLNFGGRVASRHARAAKRPKGEPERWRLTKRLSDRDTQAYRDGYPGKEDNPRLKANLLFYQGKRSSSPDGALIDDIHQDWWGNYRLLERHQGYIQWIFPIREDGMNWQAQSLQLHEAEAIRNDPKAKDRVLRSYEMMLDFYGMELKDADTGTLRRTKNWEDRYDNLSWSSHNYLRITRILKSLGELGFEHLKKPFLQFVLEEALVTTQLERTLKSCRDYWIGTVKNDADREELYRYIEEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7D5</accession>
    <name>A0ABM1A7D5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome b561</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101857273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012942274.1">
        <property type="nucleotide sequence ID" value="XM_013086820.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857273"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="25"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012942274.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27841" checksum="50563F32A23CA236" modified="2025-10-08" version="1">MQGMYFDSNQASSADMRYFNWLVLVVQVLGVVSVVITAVWMGHYQGGFAWQSDPAREFNYHPLFMIIGMVFLYADGILAYRVFRNDRKVFIKILHACMHISALIFASVGLKAVFDSHNLRTPPFANLYSLHSWIGLFVVVCFGLQWVLGFVAFLWPKLGMGARTTYMPYHQFWGVALLILATVAALTGIMEKTAHVTNYSGLPPEGILVNSLGIILLVFTGLVVYLVTRPEYKRQPSPEEDHVPLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7M4</accession>
    <name>A0ABM1A7M4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012835</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942413.1">
        <property type="nucleotide sequence ID" value="XM_013086959.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012835"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012942413.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22363" checksum="84C93D2EFD644222" modified="2025-10-08" version="1">MCRVRDYITFPRCWRPAITYYYTWSWVWLFFLQEVEAKALRVPLPVHARRRRRYAYEDTHEWPADGSMDYDFEEEDEEKEGNLWEEVARNWQVVGVRLIFVLCGVCMLFMLLFCCCNVCCRVCCHSLRENCVPCGGALEYITSCYEDPNYKRAKNLAEMMGLKLDYATYMKIRDSHDLEAGGGFNPMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7P8</accession>
    <name>A0ABM1A7P8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAC3 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942451.1">
        <property type="nucleotide sequence ID" value="XM_013086997.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863839"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF38">
        <property type="entry name" value="SAC3 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="15"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942451.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44119" checksum="92EE5089D6234332" modified="2025-10-08" version="1">MESTEAVVTGTCQFMCPVHERMMREREGLLHPLEMQSCIGESGPQKFRKADPGTTVKEFSRPAAGRHDSEPADLRPAPVLKETTTYLFEKIVPLDHPAWSSVYEFVFDRLRSVRQDMVIQGISGPDAIQLLEQIVRFHLYAAYRLRDADISSFDPVINKQHLLECLKRLLYLYQVCGGDHRHREEFESIYLLDNLGDRHAITHCLDLSPSLRRRPLLRRCFEINTSFVLRNYQRCLRLIMGLDSPLCLLAVNPHLHNLRVNYLQILSSGYSVKNCRYPMRQLQNVLHLEGSDAVVSLCSQCCLLDLFDRPDSDSVCFSKTAFRRPEKLGPPSGLATLDRLLARCSVSSLLRGPAAKLAGVTTQGKDGVGRGRGRGRGRGRARRKNEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9C1</accession>
    <name>A0ABM1A9C1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC106013075</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106013075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943309.1">
        <property type="nucleotide sequence ID" value="XM_013087855.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013075"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045625849" evidence="4">
        <location>
            <begin position="23"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="415"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012943309.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="60868" checksum="FEC13876B6999662" modified="2025-10-08" version="1">MKLTSVLISFFVLASQVDVVILQDFSDSEDSQTQLPPLPPQTTQMPLEDGPPDITMPLPSETVGPSTTAAEPAAESGVEPQSETGENPAAAPVEGGIDSDDRKDDSLVDYAARKIGEMFGSGSETDSQSSQNDTTPNLTEEQIIEKEMEECSLPDTLDRYNCTTIPKAVYDYFGGNVSVQGLLNGLYSDSVNGDLRNCTSGEWCLPFEEHLKIKQSLPEFFMKGPFCSDAMTCSLEKMLEKRERCEEKPLMYLINSVALLCDMRRSYEIDSPEPQLCQDYDECYARTMEALYVLYEDIQVPNEQHLADLERDDCNDFKVHIAKTYLCASECCQFSQREILTRFELWARLPVSAQDIQTTCNFTVDCEHNRRPSNNDENVNENVDENIDENVDENEEGENLLNAMYPDYDSTQRGNETVEEEEEEEMEAAEVMEAEAEAIDEIIQEIEKEGNETDEGTVGPTGSADNSFGDLGEFSGMDMAGGGGEDDHTIIFGVVTVASMVLLSLLLILLVGYRRFRHSKAHGYRRGYSQLTEEETRMLKNEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA32</accession>
    <name>A0ABM1AA32_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106013199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943727.1">
        <property type="nucleotide sequence ID" value="XM_013088273.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013199"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943727.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20883" checksum="50D264B3973D5489" modified="2025-10-08" version="1">MDTVSSDPSQFYSFKDTSDLYIKYRPTYPERLYEKVIKFCQESETCTWELAVDVACGSGQSTLPLAKFFEEADRIVKPGGSLILYSFGTDSLTHPEADRYMQYLDIHSKYVAKYHPATEKLINRYRDVTLPYLGWRREELEPYLRELSIEDYGGYVASLGSAQWFTDSPQGHDLPGEIIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA42</accession>
    <name>A0ABM1AA42_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein heavy chain 10, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943739.1">
        <property type="nucleotide sequence ID" value="XM_013088285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851371"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943739.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="57262" checksum="8AEA1DD481EA50A5" modified="2025-10-08" version="1">MMREQLSFTFTPLLHRALFVRVLVIKASINKSLMVWSGLVRVEMIFQVWITDLLERGIPLSQPYKLEELLTSDVEISKWSSEGLPPDELSVQNGILTMRASRFPLCIDPQQQALNWIKKKEERNNLKICTFNDDDFLKQLEMAIKYGFPFLFVDVDEYIDPVIDNVLQKNITGGQGREVVLLGDKEVDYDKNFRLYLNTKIANPKLGPEVFGKAMVINYTVTLTGLEDQLLSVIVGYEKKELEEQRQSLIQETSANKKLLYELEDSLLRELAQSKGNMLDNVDLVETLESTKTKASEVSSKLELASKTAVDIEKTRDGYRPAAMRGAILFFVLAEMSVVNTMYQYSLEAFLDVFTFSLRRSLPDTVLRKRLNNIMEALTMNIYYYGCTDPYWLFRPDTSAFNGNTSLQKSEVEKPFSWIPDVSWEDCSRLAADFPDQFSTLLTDIATKETAWKEWYDLDMPEATELPAGYDKTLTSFQKLVLLRCFRVDRIYRAIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAV0</accession>
    <name>A0ABM1AAV0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101851678</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944167.2">
        <property type="nucleotide sequence ID" value="XM_013088713.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851678"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032736">
        <property type="entry name" value="Hinderin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28375">
        <property type="entry name" value="PROTEIN HINDERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28375:SF1">
        <property type="entry name" value="PROTEIN HINDERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15369">
        <property type="entry name" value="KIAA1328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="832"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="846"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944167.2"/>
        </source>
    </evidence>
    <sequence length="1336" mass="147881" checksum="51C23AC86881FCBA" modified="2025-10-08" version="1">MADRRDRQAKETVFWTTAKGMASPTFVVPGVSDVGNLRPRVKGGRTKEVKAAVPVEQLVVETLDPLGSTITTATMLTTDVSQSNATTEVASSVPGQRVSLRDLCVEDKKRVANLIKELAKVGEEKEKAQEVLEQERLQYQEQILRLVEQQEQILQEREEVNKRLMEYQDYILRLKKERQLRAPQQPQKLQPQETAINDKIGGGVMNHGKAAHVHRPPPSPRPPPPPPLPPAMSNGSGRRNDEEGGGGFSGEEEEEEELPEQPSQNLYMNQLEETGVAEFSTQALPSLSPPRPAPPSSKPRPPRPFTTLIDQELANQKRILALTVDSAAALEGEEEEERVEVEREKRRKAGGKTGTLRDRVNTGQRSLDKQGSSEGRGGGGGDGGGRYFENKPQQVHVVAGNRAFLSPEKNELITRYMESQTEAYRAYDAAAAAVAFTGGQENNHNNHNNDVHPDRENQNPMEDGKKGERRRKKRKKQRPPSSFGPLHPPIMSSTQKSSEFVDLVSVDSLVVSEVPPPACDNHGDKRPGNLRKDGGSDGNREKREKRGGVVERKGGRNDGRNEDYESSYSDLDDDDDDDDDESVNNKAFGDGVAAAVVAVDGGRGDYNENSGRKRGGKRGRTAKVEFSDKPGQRSEEEMAAQVDPGLLSAYRQMSAPERKRELMKQRSMLLEEQNRLREILAQQEYQLKLKKQETVAKLQRQTELSKEERKEMKRMQKELSDKEMALTHKEKQLAAERESVAQRRLQQQGDAGVRGRDGTAMAAGVKDSEMKDLNLNHRRSEDVAATFAGKMDREKRIEQINGGEREMEGEKEVDRLERKKRKDGGMTDGEDGLVKKLDYSLHSDTESQCTPRTEPANQNAGSDTPPTNQNGRFDVPTNQNARSDVPANQNAGFVVTTTDGMRRREVEDGRAEGEWKVDVGTSISYAHLPREEFVGETNTATQTRRQTGAPIKTSSKSRKKQPPLSPGDKTLSVLEIINSMSPRDGAPPSAAAGRSKVNNKDSGHWLRQEARSRGHGGVSDTRSSRESWTRSARGRSSTGGTSQHAPTGTTTAQRHGDFYPDFYPDLSPSSRLAQQQHWGEGRSDPLRPGKRSWGSAKVDATRTNFGTDKPAPRRTQNLPEGFSNRTNNRMTVGGDEGEEEDQDLNLELFELKRRPPNPSRLSAAVPEVVVAALSSSHRGKHDGGSGSVLSIDGSFSTAVYEGVDYNDEDDNIDDIVDSLTSVDKIADGEVGEEEEEEGRRGRWRRSDKDNSLDYNDDDDEIIANDESYNDDNDDDDFDDDLVNVVIRTFGDALLSPRYDDDVVDDLGDGLDDGGDSDCGDGLEESQILEDVFFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABY3</accession>
    <name>A0ABM1ABY3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Structural maintenance of chromosomes protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101848082</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944778.1">
        <property type="nucleotide sequence ID" value="XM_013089324.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848082"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="73"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="335"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="823"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012944778.1"/>
        </source>
    </evidence>
    <sequence length="1111" mass="128322" checksum="94F0A548413726D7" modified="2025-10-08" version="1">MSKRRKSPDENFPTASPRKRHRLELEDEEDSGGDENDESVIESSLQDSSTSLLLANGQLARASAACAPVAGVIKRVSMSNFMCHDRLDVVLGSHVNFIVGRNGSGKSAVMTALVLGLGGKASVTSRGNAVKNFVKSGKRSAWVEVVLNNKGKDSYKPHIYGGKIVVHRRFTVEGASSYNIKSEKGQHISDKSHELARITDHLNIQVDNPVSILNQDTSRNFLNSKSATDKFKFFMKATQLEQMSSDYDQVRRKKEGAKQIILDKEQTLPGMRSEVREWETKFKNMTALSELKVKVKHLKHEMAWALVNQKERGLRPMEKTLSNEMEALPRFQKKVEDSKRQVEGWEVRHKEVQERLIECSEEVKSLEPVLQEKKRDIQKAKERLQPIQIKLKECERELAVTRRDRKQCQERIEELRTAASHDYEAERKQREEQIAKLEGQLEKLSLELRVKEHSVEQFRGAVAKNKSDLAAIEAQLKSREHRLRTVENTLGDLRRAKDDRLLRFGAWMPAVLEKIRQNSRKFHRVPIGPLGVCFDLLDSKWAMAVETCLRGLVSSFVCHDHHDERLLLSFFSVCPRSRRPTVIISAFSDHPYNVTSTRCQSDRYQCVLDVLKCDDPMVVNTLIDQRTIERVVLIEDSGEARTVMQRHPPRNARECFTLEGDQVYSEPTFRYYSNDKMSVKFLMADVAEQVKALERDQDHLTKERARLIEQARSSKYEMGRNQQEEKKLLTQCNKNKEQAARIDYDIKELRNMEDPLPVDVTALEEEVRGFGEKEVELKTRAEGLLDEKRVAETDMAAVKESYAAVEASVREKSDCGIPLREEISQAQVEVEKARNERKHYLAKLKEQERKIQLLDADIEKYKSDLESDRAKATEICPPIATKRTDSSIENEIRQIQRRVEEEEEVHGNEREVMETYKGKKERYDQVMGEVRQLRNYLSKLDEVMERRQEAYLKMRKDIASRTKYYFIILLFQRKYGGKMMFDFDKKTLDILVKTEGGVKVDQAEGKDLKALSGGERSFSTVCFILSLWEAMEAPFRCLDEFDVFMDMVNRQVSMDMMLETADMHKDMQFVFLTPQDMRSLRKIDNVKIFRMPDPERSQKTLNFSQNSTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACU4</accession>
    <name>A0ABM1ACU4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malignant T-cell-amplified sequence 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101861086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945250.1">
        <property type="nucleotide sequence ID" value="XM_013089796.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861086"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="5">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012945250.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21197" checksum="7BE961990804C63C" modified="2025-10-08" version="1">MFKKFDDKENVGNVNIAKSSVLKGIRSQILDQFHHVESYLDQILPKKEPLKIVKCVLYFPSHEHIELLCSQSGEILFFRQRDGPLFPTLKLLHKYPFILPHMQVDKGAIRFVLSGANIMCPGLTSPGARMTNVDKDQIVAIMAEGKQHALAIGQTKMSTEEIVTKNKGVGVDNIHFLNDGLWLMKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEX5</accession>
    <name>A0ABM1AEX5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Active breakpoint cluster region-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864282</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946368.1">
        <property type="nucleotide sequence ID" value="XM_013090914.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864282"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037769">
        <property type="entry name" value="Abr/Bcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182">
        <property type="entry name" value="BREAKPOINT CLUSTER REGION PROTEIN BCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182:SF1">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="629"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="829"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1028"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="895"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012946368.1"/>
        </source>
    </evidence>
    <sequence length="1380" mass="153363" checksum="EAEB83BD51D2F9A3" modified="2025-10-08" version="1">MSSSPHYPSVTEVGEGEIGDSNRGPCQPHFELSDNSTRVGGREGGGEAEEERDLSAKTNTAEVAECSAEDVGTSGPGFEPHLLGREGERREARRSSIGQLVLGSSSYFVQAHTALSRPHTDPHTDSHTDTHTSDVGGEHSSSPPAHSRPAHTQGAGHPPTSLSPPLQLCGGAVENQPDPSPLLVHHNDTTLSDDTTRALSDHDTTHDTTRALSDHDTTHDTTQALSERDDLKDRTQALSDQHKNTHKDTHKDTHKDDTGVTSQDFPLPSRDPVSPPISRDPLSPPVVGVRTSNVERCDSSDTLVSGDRDRARSESFTSDLDVRDAIRDLENVIRTERSDSVEDSWSAMTTPATPTTPTNPTTYRPRAAPPPPAQPRGRARPPSYENWTINRAVTTSLSQPPDFVSVSDEDDLDDLGSPLPSPLLQRPPGRARDSPDSGLSDDTGLVDSGHHPPGPATRPTVAASSTGGTRSLDHQPVEVRGGRVRDLRRIHAMSLPTEEGREEEEEEEILVDEATLDKDIDRISVASDVVFIPGPESRGFSLVHGADDVSERSRRRQAESGGVGGQADDRTDERADERSDDRSDDRSDERREDRTDGASITSSGEEESSLLMDSSYDESDSAREGTLKMRQLLVKGVLDSEKAYLDILNLLINYKKMLEAAGTTSQPVIANEDIQSIFFNIDTLYKIHQDFVQALEPKVRHWTHDERIGEIFKILVMRFDAFKHYLTHYQEAVSTIHRCSQESSRFQELAEQIIVNSTIREVTSLEDALFKPVQRVQRNTLVLNDLLKYTPSDHPDCAVLQKAHKLSLYNLEKFAQTAPKNHTTQENRRLVKSSFLVELVNGVRKLRYVFLFSDVVICTKRETNRNNKASFDIKWYTPLSHASCDTRFAYTDDAKHSKREDIDELKNKLRTLKKELKTEMKKYDEKDKHRSIVSLGGAARVVEKLRKKINHYEAQLILACPKLPFKVSLHGGKVYTLLMTTDYEREEWKETIASLSKKCVPGDQQNQMSSIFIQELINSVKETPQINKIGNVLLQRDEDMLNGILNVTIHKLNGLSEECDTYCCLEMDSFGHFFMKARTHICEGSRDPAWNEDFELELEGSQTLRILCFQKLSREHGDDLLGRGALELSKSWLKGSFQEKTVAMNEVSLVISVRHTPAEKTMRRTPSMTGSAVFGVEIASLARREGKPVPSIVTACLKEVEKRGLDEVGIYRVSGVTSELQSLKKLFDKNIKVGAAAVTDVDIHAVTGVLKLYFRELPSPLFTEESYQSFIDTLRLSDEEAKAQCMLALLHGLPDTNYFTIVNLMEHLIKVARNVGENKMSIQNLATIFGPTLLAPASKETSSDPLEMMSKGAEQVMHQSSVVNYLLGLAVSGRSLRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFL2</accession>
    <name>A0ABM1AFL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC106014158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106014158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946689.1">
        <property type="nucleotide sequence ID" value="XM_013091235.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014158"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF4">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="743"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="802"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012946689.1"/>
        </source>
    </evidence>
    <sequence length="868" mass="92991" checksum="15B2CDEAC1178E86" modified="2025-10-08" version="1">MTSDDDPIVSRAGSTREEQETAASHQRQAPSPVVRSRSRPAGTMTWEWREQLMTCYSTMTWVSLGRVRSENVVGTCPADVVVSMDIPHDSTSTVISHNTCTNIPRDLTSTDTPRDTCTDTPRDTCTDTPRDTCTDTPRDSAPLTDDHKEGLPLSDDHKEGVPAPQVRADVSRRTLASPGDQDDGGLLLLLPPPASDLSDRCDVTRPVTSVPYGPSVQPTRPEVTPQQGDLTHRPHLCNRLCDLDISSLCDLDIFSLCDLDIFSLCDLDIPAPCDLDISSMRDLDIPPLCDLDIFSLCDLDIPTLCDLDISSMRDLHLPTLTPAQDTKPPKTGTVPQCSNMTQKPRPPPLTTPARPTSQQSAPMAAPTSVWDTHLVCVGQPVFLIFFRIKSDVFCVKRPEADTDERLGRHCHLQLPVLPCPSDADHSPPRAVRGDGSVSTCVVCESPPDSVSTSGAHGSPPGSVSTCVVCESPPGSVSTCVVCESPPGSVSTCVVCESPLVSLTSRHGHLRSTVSCVHSHSRYHTNNTEVSGTEDLCSIPHGPVVVCIPHGPVVVCIPHGPVVVCVYSSVAGSQTLSSSPGEQSPSVHFHTAPTRSPQPASLFCPDCQVWDIATSSITHHGTPTAPPTVPPPGRVSQTHVLTPPTQVLTPPTHALTPPTQVLTPPTHVSTCAMDVGDVTPWPRLLSLLAVLCVAPRPRPSPLAPPPARRLGVAHVCLLLMALTHVWPGVLLTHAQGLSGTVSRCDKEGEEIAISGITDDPCISCVCKDGLVQCETKQCARLEGCHAILFDHPSGRCCEMCKGCRYKGAQYSSGDSWLDKSDPCLRLSCRAGVVSRSRARCFSHCHSTVVVEGMCCPVCAGCYFRGHTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFN7</accession>
    <name>A0ABM1AFN7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MLX-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101859304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946729.1">
        <property type="nucleotide sequence ID" value="XM_013091275.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859304"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21739">
        <property type="entry name" value="NES2-NLS_ChREBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF37">
        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="883"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="389"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="807"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="925"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="836"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012946729.1"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119993" checksum="004A8072D6263FB3" modified="2025-10-08" version="1">MAVDDVRPITSHSNMLDIKLERQLSESSQQKGTIHSGHFMVSRVHDVNNEDDDEEVASPFSEDTKGFDFLSASKETSKTYDFGNGSQSIIDASLTKLFECMTLAYSGKITSPRWKQFRGMPMSQKQRIRLNNLIWREWHMQYIYQRHPIVCQFATPLWDHIHSKPEAVVLEGKYWKRRLDTVTAEYKKWRRYFKERISQKQGINYKEMNNLAEWELLERVKDVTFIPHSSGDQMSSTDLNLPQADVMDMDFPNDLFPFLNQPFAFPNPRELSQLGCADLIQPGLVQLQPNLEEYMDIDSMQELFNARIPSSSFMSDTSPSIEMTSSTMQGPSITDSQELSLVDFMSSSPGLVPRVVSTAADSGVFASTPSLTSATVTQMQQQQQLQQQQQQQQQQQQQQPPQSITFHLAPNSSGQYPVDSATILLEPPSDGATGSGMVVSPPTFTIVPNSSGLYPNFLGPSALSLTTNPPKPAAPAPVVSVDSSGGGRNITALTQDLLAQMLQQQQRQQQQQQQGLSASTTQKHHQQQQQQQQQQHAAQVSSQPIQLSLSPSPVQRQPHQQLEQRDFSVPLLSPTAQSHQTLTSQLHQPQAVVRPTLQMRNLVTKGNKLAKQSAAAVNNSSASGVMSGLAKLAESNKKKDGPFAVPAKPVIVPRKNRMIAPAPSTTPLQQNVVAPSPSSQASYLAELLKNGTYRGALINVKKEPVVASSPIKTTTNYQHIQPSPLPLPQQQQQQQQQQQISSLVTIASASPVHSTLPSLLARPSQSSVEVPSSISQGVCGVVLSSPLSGVDLNPSQDLKVSPLRFAQSPDNKVSLGGSPVSLLPKSPGMSPEVKRSPSPLMDTSSLLDSSTGSPLSSVMPMSPSAMGGADSPGSSDGLYPKGNRRAAHLSAEQKRRCNLKTGFDMLQQLVPSLSQNPKVSKATMLQKTAEYCKKLKAERSQMQKEAAILKQEIEALNSAISNVQSQLPETGVPVTRQRKDQMKEMFDEYIRVRTKDNWKFWIFSVIMNSLYDSYCNTVSTASLEEMCRTSLTWLDQSCSLVSLRPNVLNALRRLSTTTSILTEPQKVKEQALQAVTKSQGKTQGNSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFS5</accession>
    <name>A0ABM1AFS5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin-specific chaperone cofactor E-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946788.1">
        <property type="nucleotide sequence ID" value="XM_013091334.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847085"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="425"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012946788.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="57900" checksum="9E5593ED342241AD" modified="2025-10-08" version="1">MSEEQRDVLLEERPTGTDVPHEPEENISPTNEECRLPVCKSASAALEVGTSGSQSELRQTSSGPQCDVNKEESGGDEGVTEMLKSFVLAVHQKYNDDTHVADAVGNVVLVPKRGPVKMTASGSIMLPRQVTMSGCEISVAGDPQLIQRMCQKVQELDLMENHIKKWEEVFAIVRCIPHLTFLNLTKNHISCDFPNLDCWTSSCLKHLVLNDTLVTWDVLIKLLDVFPLLEELHLSVNEFQSVDFSTGSSLSTPLLTYPSLRKLFFIRNKVFQWSELSKLGSFFPGLQFLMLSETEIETTENGTDIQMCFPSLSVLGLNRTQLKSWEDVEKLRHFPSLTDVRLNGIPFLEAFDEKFKRWHTVALLPNIHFLNGSPVLENEREDAERAFIRLYMDSPDKPHRYFELEQQHGRLDPLVKVELKPKKRVRLLVKVESSSGDLKSSELMDIDVSQNIKDLKKLLSNVAGCPTSKLTLFYLDPEGYCGLERLMSMERKVHSYKMKDGDEIVIVIKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFT4</accession>
    <name>A0ABM1AFT4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B(0,+)-type amino acid transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106014194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946800.1">
        <property type="nucleotide sequence ID" value="XM_013091346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014194"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012946800.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22373" checksum="CC7B9DCD7E02247A" modified="2025-10-08" version="1">MLGADAVAVLWGDRVLGAAADIIPVAVVISTLGAASNGFFGNTRLIFTAARDKNIPDVLSYIQVDFLTPICAMGLLLGLALLFLVPAEVGTLINYIGFLNAFFNGLVYICFLVFRFGSMRDAHRPIKIPLVVPIFMVILNIYMFVAPLAISPEVQYAYVAAGVFLGSAVIYVPFIFFRVSVPFYDRIVPVIQLCLRVSPPAKYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG40</accession>
    <name>A0ABM1AG40_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADAMTS-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106014237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946974.1">
        <property type="nucleotide sequence ID" value="XM_013091520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014237"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF305">
        <property type="entry name" value="PROTEIN MADD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="ADAMTS/ADAMTS-like Spacer 1" evidence="4">
        <location>
            <begin position="208"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012946974.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35064" checksum="1727223173B83629" modified="2025-10-08" version="1">MAGLSYLLCECVHIIAVISILFLTCYCDDPRLHPLRDPVYWGPWSSWSACSSSCGRGVTTKRRDCLMWRSVEVKAAKPWKCQGRDTRRRLCFSQACPGNRMYDQSVDDECQVLQHARRSRHRHRNWQRVDRGNPCRVVCAVIGGYTVRTLQVLPDGTVCSQNGARYAECNKGICKEVSRGCHDSDGTSLRLDMCLVCGGNNSSCDQVTGSFRASTSRTETYGFSGVVRIPQGATFINIVKEGDISSAIALLDSLGQHVPASEAGKRLPVGSNSFPAEGTNWLRERGIYRETLTATGPTVGDLTVVVSRRSVMELVAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSE7</accession>
    <name>A0ABM1VSE7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phthiocerol synthesis polyketide synthase type I PpsA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC118477585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825339.1">
        <property type="nucleotide sequence ID" value="XM_035969446.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477585"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035825339.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="8867" checksum="AC98AA42CAEB11A3" modified="2025-10-08" version="1">MVGSVKTNIGHAEATAGFNAVVKCIFGIEEGLLPANLNFERPNPEIPGLLDGRLKVVTEMTPWSGQVCGISGFGIGGTNSHCVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTJ1</accession>
    <name>A0ABM1VTJ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846814</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825733.1">
        <property type="nucleotide sequence ID" value="XM_035969840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846814"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825733.1"/>
        </source>
    </evidence>
    <sequence length="1258" mass="138049" checksum="1B27500EA26F5FC1" modified="2025-10-08" version="1">MADFVVQDVSDLVSKEDDGPAAVWTLEQPEDGDLPQWIKSRLGENYVVKLVAPTGSECCTVEQDSAQHDNGSPREAEGSIELSSADTMEKSSFYSVSAPIICSQGYKAPKSHPMLKDNDAERSAEAIALSVSGEGVLLQSNNLATSPDLNLKALLQMLEKNSDTVAEAGCNSDVLNTSDSNSLSDMTLDGGQLCSAGTESSRDVLEAGGAQKPLLLRGTVPTATVHSLGVVHPSQFIHQPLETRGDVANSWSYSVQLPGSDTVSADETGLYASSKECFENDERLASDIETQFGRYSPSCKSVGRRALNRSKRGRRRKPIRQFHSELFMRPYFRREQSPQLQLVKLVRQKSQNEDEKAALALEQMVHEKEKLNCVDNPELAFMKTIDMPSGKRVEDIYVVPSVWISDEKKQAPSDLESQEANLALSAALAGEKGYHDVGESPQMPLRVYQCEGHHGALAAVSSSHIMKNSSVNVHQYRHILPSSFPLARRKILSVPVLLDSQALSRGPDLGKGMKGHIITTLNAPKLEPVPTLRDLCRAALGFREYRLGCVGEIIRDNISPSKKQLEKFVSLSPEEEEEEEEKILEECSSSRVMSPKEFLDMKEDMSEGKPISVPREEEATSILSFSEEDEKVSGTDPSNTIDATNGVQEGLGVKPGENTDSPCSLPGLMMGQTMNFVSENPLEKLENKRAVPCDLKDTMGTKMLSNEPSETTREHFCLDDDQEKPNKFVKSRLIGNDGEQNVFTHEEQGFEANDRTDSHNNIVIPVVSFDCKDAHPLPQADGESHNPVIPRLPHALPMSHHSGSRTVERFDITPGETATSTKPDPSVVSITKQIKHLSCLEPLNKPLADLAATLNVLCNAERTLCNADFAAYRQVKGTQESRSGSLNMCILRLGEAVVTVGNTLQAWAKDVSGNRCFKTIGILTDSYNTNIVTLIDLITPYFHHICELIANCRMDPSTKNKHLLSAISQDGDPFSSSYQDSYDVGRWCSATVSSSSTPAASDPPLSFTHVSHQLAAPPAPPVDGQRDGDWFYSLEEAHRNNYVQLAMKPNLSRMKSPGSFKIKAGSKRGRPTGSKNCQKRRKVSLLRCRKPLLEIDQNKLNPSTPRNVLSVSSVESSTSCEELKSHNVPHSGLVEIPSENFCSPLIMSKVQQQQQPQPHTYQAMIRSGNGLCESLPKPDQMVTTWTLPVRTYCSTGDPSSSQHKLPPTETDDDKSVLYQAVAGSGYEASVVEEDSNCSMDLRNGQKLDENGECKSKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXY3</accession>
    <name>A0ABM1VXY3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101855358</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035827276.1">
        <property type="nucleotide sequence ID" value="XM_035971383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855358"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047275884" description="acid phosphatase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035827276.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45980" checksum="E4E9E408722C7D04" modified="2025-10-08" version="1">MDVKEFGSLSMKRLIQLCLCVCCGLQVFGAPPPTLKLVSVLYRHGDRSPAYIYPKDIHQVPGSWPDGLGWLSNIGKQQQYELGQFIAERYSGFLNTSYYHRDQILIQSSGVERCLMSAQSNLAGLFPPQGPQVWNSNFTWQPIPVQSTPTQNDNKLAIQAPCPRYDQLMAEVLHSPAIQKEEKENKAFYDMVINATGVKKESIRDIWMIADPLICERAHNYSWNEWAYQEGVWEKMDSLRTLSFDLLYRRTEMAKLKGGPLLKEIIYNMKNASGESSPSPRFYMYSAHDTTVAAFLSAMQVFDLHQPMYRALVMVELHHINDQHVVKIFYRNETTADPYELSPPGCKNPCTLDSFIEATKATVPEDWEKECQALNSSASHKLSPVSSLLIRGVAIISMFMAVTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W170</accession>
    <name>A0ABM1W170_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding cassette sub-family A member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118478604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828413.1">
        <property type="nucleotide sequence ID" value="XM_035972520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478604"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="6">
        <location>
            <begin position="243"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828413.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="40122" checksum="A4FBBCE219AF163D" modified="2025-10-08" version="1">MKLPAQVKLILWKNFVHYKRRKWMTLVEILLPSLFAMMFVVVRELVDKTEIDYDTFYKPNNTVLEYKPISFNLSDDWIFGYVPSSPIGEEIVNRTLEGFRRKAPWAENATWSVRGFETDQQLLDFYRLNIAHMPMCFKFHDVGPTSTRLGKTASYAIRPTTMREDKWQTDETYPLLRRLRPEVNDLTEDDRPHYRDRAVLFFIRLVDEAIISHWGGKPYEDWTISTHRMPYPPYVDDEMTVVIQQQLALYLVMSFILTVVQFTKSIVYEKEKRLKESMKLMGLKSSSLWISWFLTSMLFQIMAILIYSAIMKTVTINPIFFLQTVTINPNYITIYRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W218</accession>
    <name>A0ABM1W218_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013402</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828711.1">
        <property type="nucleotide sequence ID" value="XM_035972818.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013402"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828711.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27730" checksum="0C5E710F47982097" modified="2025-10-08" version="1">HTRTHTHCIYHEHLYSTGKRITKSKIVYFFSACDKFPNYKACHAPPVIIPGPVNDVKLTLVPYWGRFLGLVSWQPPDKFGSAGVVKSYHLFWGIINLRRHDLISGFKKILGHIILPATELNADLDINMTRLTTYETVGVLIRAAAPSQVIDSPFGDITLASNTISPASITRSVLLRQKDVVIVQQDEEEEEGGQAEPVEVEVYWRQPPTDSELNVTAFGVQWGRLSRDNENGTSGSAQLLDGNFTVTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2B4</accession>
    <name>A0ABM1W2B4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828807.1">
        <property type="nucleotide sequence ID" value="XM_035972914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847294"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10283">
        <property type="entry name" value="MnuA_DNase1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051675">
        <property type="entry name" value="Endo/Exo/Phosphatase_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00426">
        <property type="entry name" value="competence protein ComEA helix-hairpin-helix repeat region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF32">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="3">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="3">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="3">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828807.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="64517" checksum="B23D9A772E23E639" modified="2025-10-08" version="1">MGGLNSCCIPRKGFGEERHATTSTPKGKGHRRNLSATFNLSTIESEKSTVASLVNVNTAGEEELMTLPGINRCIAKNIIDHRNHIGGYRCTEDLALASGVGAERLATIRDDIYVIPPVLDDRKSSEGKAPLRLLSNASGDDENVTQVNINTANVFALLKVKGIGMGIAKNIVVYRDKHGTFSSVDDLIRVKGIGPTSLDAFRQYVCVADKFPVNSNDHSHQNGKSSCDHSSRGGLENDSDYTRRSTSSLENLLEILGPLAKIPERPNVAPITLKHKNRKVFRLASWNLERFSTEKAKNPGVKDVICMTILENGFSIIAVQELADEEALDEIVQELNHPTLPNVKKWSGRRGKWACVVSKAAGRMFQSMEYLGYLYDKSQNIEIVHHSLLQKKEGHKKPFVRMPYMGIFKINNNFDCVVTNVHLKATGLDDRDRHRTEKEVGTVTDLIDVIKAEIRGEKDVIIVGDFNLEPDTEAFSTLKSEDYTPCIPADTHTNISNSNVSGSKNYDNLWINKDTRKVYTGVSGVVRDGLSSHWIPNGWTWGGVVSDHCPVYGQFYSNMDLDPKDINTSDVSFTLGHAQIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2C4</accession>
    <name>A0ABM1W2C4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 239-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC118478760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828817.1">
        <property type="nucleotide sequence ID" value="XM_035972924.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478760"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035828817.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11739" checksum="425199C0A9147A82" modified="2025-10-08" version="1">MHTGEKPYRCEVCGAGFVNSVQLKTHRGIHAGVKPCKCDVCGAGFANGDDLKQHKSRHDGEKCYKCEICETSFSRKSNLQIHRRIHTREKPNKCDDCDVRFAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2G0</accession>
    <name>A0ABM1W2G0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Slowpoke-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828853.1">
        <property type="nucleotide sequence ID" value="XM_035972960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848787"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22064">
        <property type="entry name" value="WH2_WAS_WASL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF8">
        <property type="entry name" value="FORMIN 3, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="3">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828853.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="54881" checksum="AEA6B0A81E763166" modified="2025-10-08" version="1">MADDFGEWLGDHIYVPILAGMVIAFALLFLIYCGCKRRRSRASYYVYKRLEHEAELAEQMNRERETQQNVLRDASFMNSQYYLRSHPYYTNMQQFKDLGSRIDKHWFLVTDMRNNQERVLSCMQFNSKMAVPFTKTTCKTLKDLFSLLQHPHIFPITDFDFSVEQNLIFVFQPVSLKGSLKDLIYQCRYSESWYSKYSQRHKGLPVQNIKTYGKQVLTGLLYLEEKGFPPHGNIQSGNVLMDNGVCRIAGYENRFLANTSRVYSLVKKKLKDENKGALDTLCVGHLLYEMAFGYELDAAHPEPQHLIGHQSPVVVEILNFIFENETGKYPTISEVNSHEFFASVGLNEMKRYNPVKIHLSEPMKTLLKAVKKDKPLKPPKPSSQSASKKKRSKGNSSPTTSQVTSPTAGPSGLHTQLSTSAIPPPPPPPSAPIPPPPPPPGGSLPPPPPPPAVSSPPSSSSGRSALLGDIRKGSKLKKAITNDRSAPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2G8</accession>
    <name>A0ABM1W2G8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myotubularin-related protein 13 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101856614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828861.1">
        <property type="nucleotide sequence ID" value="XM_035972968.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856614"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20827">
        <property type="entry name" value="C1_Sbf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13208">
        <property type="entry name" value="PH-GRAM_MTMR5_MTMR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01235">
        <property type="entry name" value="PH_Sbf1_hMTMR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14534">
        <property type="entry name" value="PTP-MTMR5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF109">
        <property type="entry name" value="SET DOMAIN BINDING FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UDENN" evidence="8">
        <location>
            <begin position="6"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="9">
        <location>
            <begin position="1132"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="1865"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="1960"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1335"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1335"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035828861.1"/>
        </source>
    </evidence>
    <sequence length="2064" mass="230621" checksum="93C0A9C989A3B6DC" modified="2025-10-08" version="1">MSRLADYFVLVGYDHEKDRSGTSCGKILQRFPEKDWDDCPFMQGLPLFCQPVGWALYNQRQQPSFYVAVLTDMDGERHYCAVFTFHEMVAMTPCKPDDEEDEQEGSIIHHSSMFAPKSIALISRHDYIEAFRNCLGIIYTVHLENLTVKIETLVGNILGCVQVPPAGGPQVRFSIGAGDRQALQPALSASLPVSHISVAILFEQLGVNNTLTVFAAALTDHKILFYSESCSRLSDACRALTVLYYPLKYTYVFIPVLPTSLLEVLNSPTPFIAGVHAKLKDDIADLLDVIIVDLDGGSVRIPECVTIPPITDSILTSAKKALTMILNPDLVCADYAYAPSPKKLASHVHRDKELRSVFIRMFAEMFSGYRSSLAIVRIHPTPFITFHKAHFLGQRGMVEEEFLGRVIDSMAFSSFVAERGPPYRVCDIFDEVSATIQEQLQEEHNNPVRMMENIKELAHHLYLNECPSQQPYVPKVPKPTEGAYARIHQPAFPTLDGKMIQDIIDEGLYTNNTKKLNSVRTQNVRMVPMSSSIGAWSLQKTLENNARRLEVLKSCVNFIFDNKIPDARIIFPAVLRALKSGIARLALTQELGEHVRSNRAMLEHQQFDLVVKLLNCALMNDSSLDENGVAAAVLPLATAFCRKLCTGVIQFAFTCIQEHAVWGSLQFWEQAFYQDVQIQIRQLYLPLYEEHVLMKRSTDSASIESPNGSENGKSSTLVKPRQIGALEITAEQLRIWPTMSDEQQREMINNEESTVYSQAIHYAYRMVYLRVPLDASRSMKNIAIDENSSTVTPSVAESDSLDAESGFDETEQTDVAAVVTKFVSRFVDKVCNDGGVTQEHVRALHQMIPGVVAMHIETLEAVNRESKRLPPVQKPKIITPSLLPGEEVVMGKLRVYLLPDGREEGTGGNMGGPCLLPAEGAVFLTTYRIIFKGTPCDPFASEQAILRSFPVSSLTKEKKINVQMYLSHLDQGLQEGLQLRSNVFQLLRIAFDEEVTSDDIEAFRKLVNKVRNPATVYSTFAFTGYAVHASTQMQKNKEKNASLRQFAKRTLLKTARKAGLKKHNRNKPKYSITSPPTSRRSGNSSPHSTDSESECAGSVHNDDLSVSPFSSPVIDENELIPSYSSDPKNVERLMERHAYQDYQRLGLGSVAMSGQRGGRSEPFRVSTVNSTFQLCRSYPGLLVVPQSVSDESIRKFSRCHRQARFPVITWRHPRTRALLLRASGFHSRGLMGMLKHNAAPSTSSGEASSSIEQEKYFMLLVAATPSSHRSSNNALVNSASDSLTSLDSLMMIGVGGESLNIMPTTPEPLRHTASSGGSGAGGVVSGGGGVVGGGSGAGAVGGGRGEALDKRVSAPPGPASATKAKTAFLTLPRRVSRPGPSVGRVGSMRERSPNLNIRSRTSRDPSHGNLVDNSIKSLHHVALYVLGEKAQMKGIKMESFPKCDFIPVDFYEVRQVKASFKKLMRACVPSSPPSHPEHSFHKAVEDSEWLLQLQSVLQLAGAIVDLLDLQGSSVMVCLEDGWDITTQVMSVAQVMMDPYYRTMEGFKTLIEKEWLGFGHRFSHRNNQTAATQTSGFAPIFLQFLDIVHQIHNQFPLSFEFSQYFLCYLAYHCSSNRFRTFMLDSELERVEAGWLLEERRPSLGSDSRSEDSTDHHAKLHLPGLTDHRQGMSDHRHVPCGASLWAHIDKQSKLSPAFFNVAYAVEEQEPILRPYSNVSNLKIWDFYVTEDLSRGTPYDIDIEETDGLREELEAEAMGVTRRQTLNACYHNIERVQPNCFWSKIEELHRIECDMGIKPSPWRAVWDRLECPGREQFHRQPFPPFSTQVSLNTQLVRSHGRSFHKRSTLEILVRGKMLGEAARIFSQPHRFEKHTYTTSTFCDHCSQMLWGLSKTGMRCVDCGYNCHDKCQQYVPKNCQKLRAVGESGVATQNLQSNGAASVNASAATSSDGFGQYKSSSPEHRTHEGHLFKQGALFKQWKQRWFVLDSMKHQLRYHESIDDPHPRGYIDLAEVESVSLVKSMPGAPKRADENSFIEIRAMRRVYNFMATDSKSAIDWVDKLQSCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3P6</accession>
    <name>A0ABM1W3P6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829289.1">
        <property type="nucleotide sequence ID" value="XM_035973396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478913"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829289.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="86133" checksum="19DD13331FD789E8" modified="2025-10-08" version="1">MLSSSKHRIRLEEPPQHESPDYRHGYHSSLTAGESRHWYSTVKPSEGVDDVTVSQQKRSERELSLRHDRLVSETVQHLQHQHQRHNSLLQLPESEHLREPEQLTQRHFRDVSYQHDSRVSSEMMRESQIQQKQQKQEEQQSSVIPSSEKHSQFGQLHGQSQFYESVPAKSDGHLPPPPPHHHLSRRHPPPHSKQLHHHHHQPQFDHHQRAEDRTYPRQQQLSLEVQQSLSLHREHGYLEHGSSKEQSQYQQQQQWQLDRINLPDDYNYRRVYQRDYTDLRTVEHSSLDRPLEHSSLVRLLEHSSLDRLEHSSLDKPLERSSLERSSQDRPLEHSSLVRLLEHSSLDRLEHSSLDKPLERSSLERSSQDRPLEHSSLVRLLEHSSLDRLEHSSLDKPLERSSLNRPLERSSLVRLLEHSTLDRPLEHSILDRQERYSQDRPLENSSLDRLLEHSNRDRRVERSSLDRRVERSSLTVGLAELPETEARKAYSPSQPHHFHHRIDVQEAQPQRDFHELVPATTSTPHPHHHHYRQSYHHDHHHQRPSSEQRHREEKSHDKFPSEKSYRHVSLTPSLPPPLPSYRHHDIHHHHQRPHHPQRLDDPPQQHFYQLLQPAHEEAQRQPQQGHQHLQHPSQQQQFHPHLRDELDDHYHGSPHHVIHSQHLPRGHVTDSAPEGYGQGIGDDGGRPLESRRYHQLTAVDLGPAQGYLGEPQPKPGVASGTDVDVDPYYLVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4B7</accession>
    <name>A0ABM1W4B7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted RxLR effector protein 78-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118479039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829510.1">
        <property type="nucleotide sequence ID" value="XM_035973617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118479039"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829510.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13988" checksum="6BEB0A3A8E7DE100" modified="2025-10-08" version="1">MGSDGEKAFDQVNRNKLWKILEQYEIKGQLQDTIKAIHANSRSAVCITSGTSDWFPVTAGVRQGCSLSPLLFVIYIDQITKEANPDPEALNEVMFANDFAMMNNRTQLQEHMNQLNAPKPTSSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4V2</accession>
    <name>A0ABM1W4V2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin delta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Delta-tubulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">LOC101855927</name>
    </gene>
    <organism evidence="16 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a positive regulator of hedgehog signaling and regulates ciliary function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091576.1">
        <property type="nucleotide sequence ID" value="XM_005091519.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091577.1">
        <property type="nucleotide sequence ID" value="XM_005091520.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829695.1">
        <property type="nucleotide sequence ID" value="XM_035973802.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855927"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02189">
        <property type="entry name" value="delta_zeta_tubulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002967">
        <property type="entry name" value="Delta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01224">
        <property type="entry name" value="DELTATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="9 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005091576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005091577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035829695.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="50188" checksum="9C1B6354F7F9D1B5" modified="2025-10-08" version="1">MSLITLQLGQCGNQVGGQIFSTLVDDIFAKSTGLSNKENQAYMQSSLEKFFTQRETAGRDGSSSLPMARAVLVDMESKAISHTLQQAKKSGRWTYCAKRSYHQKRGSGNNWAHGFCVHGPKSHEDVMDLVRKEAEKCSRLGGFVSLMSLAGGTGSGVGAYITQSLRDEYPHSFILNQVVWPYTTGEVIVQNYNAVLTLSHLYDTADALVVMENDTLHKICNQLLAIKNISFEDINRVIAHKLTSVLQPCVSDSAGGGQMCDLGSMLEHLVPHPQHKLLTIKNIPQMSDVAREFSFHQWSGLIKNLRQMLIANAPMEEGINWAIKPSSRTASGHTCFNRSLSSLVVLRGKDANSVDPFYFTDSSIYTPWMPSDMTCCVARQPRLFCEYEKSAALVSNSRASVQPLNRIIDKAWTMFSTRAYVHQYLKHGMTEEDFLDSFVSLEKVVASYDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W530</accession>
    <name>A0ABM1W530_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101861423</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829773.1">
        <property type="nucleotide sequence ID" value="XM_035973880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861423"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF58">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="47"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="529"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035829773.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="67552" checksum="8D161C0104381ABB" modified="2025-10-08" version="1">MANNVTSELFQPNATVQSTGTTLAFDQVSTGETEKAREARTWDDATWILTSAFIIFTMQSGFGLLESGCVSPKNEVNIMAKNVADVIFGGISYWMLGYGLSFGDGRGSNGFCGVGKFFIDPEDEAMGEEFSRFVFQSSFATTATTIVSGAIAERTRYIAYIIFSFFNTFVFCFPAHWVWSKHGWLNKLGVVDVAGDGPVHIVGGATSLVATLMIRPRAKRFTPQDDHEMGSPTGALLGLFILWWGWLAFNCGSTYGISNGKWKMAARAAATTLMSASAGGCVSFIASYVVNKGKFHVQYIINGVLGGLVSITATCAVTGMWESIVIGAIGALLCLSSDSLLAKLRIDDPVSAVSVHWVSGFWGLLAAGLFTHKDTVAQFFANRHGLVKGGNFYLLGVQTLAAVAITAWSATTSALILKVIDLTVGLRLSKEEEELGADLIEHNIGRVLVVESLSKRSNDENGNQPQFANCSHTNCIPQRMDHDLETSTCTSQTDTGRASVINSLSLDNGLVLRIDSRSTVPNDVMLSDSVTNGSTSKDRRSSIGRAFSLFGKKRRGSKQNTHRMNTRNKQSKRHSDVTTASETCPDVRMFKMARKSSLTNYSSSVNMLSFTSREDLDEMVTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q26268</accession>
    <name>Q26268_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Calreticulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">calreticulin</name>
        <name evidence="21" type="synonym">LOC100533294</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="1992" name="Neuron" volume="9" first="1013" last="1024">
            <title>Long-term sensitization training in Aplysia leads to an increase in calreticulin, a major presynaptic calcium-binding protein.</title>
            <authorList>
                <person name="Kennedy T.E."/>
                <person name="Kuhl D."/>
                <person name="Barzilai A."/>
                <person name="Sweatt J.D."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="1463604"/>
            <dbReference type="DOI" id="10.1016/0896-6273(92)90062-I"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 16">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="S51239">
        <property type="protein sequence ID" value="AAB24569.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="JH0795">
        <property type="entry name" value="JH0795"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191523.1">
        <property type="nucleotide sequence ID" value="NM_001204594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q26268"/>
    <dbReference type="GeneID" id="100533294"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000002">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000122">
        <property type="entry name" value="Calreticulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009169">
        <property type="entry name" value="Calreticulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF2">
        <property type="entry name" value="CALRETICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002356">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 13 16" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 13 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18 21" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18 21">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012113302" description="Calreticulin" evidence="18 21">
        <location>
            <begin position="16"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="193"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="339"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="344"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AAB24569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="NP_001191523.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46738" checksum="14CAA201840D1D69" modified="1996-11-01" version="1">MKVVLLCALLGIAFADPTVYFKEEFGDDWAERWVESKHKSDLGKFVLTAGKFYGDAEKDKGIQTSQDARFYGLSAKFDKFSNEGKTLVIQFTVKHEQNIDCGGGYVKVFSSDLDQSDMHGESPYNIMFGPDICGPGTKKVHVIFNYKGKNLLVKKDIRCKDDVFSHLYTLIVRPDNTYEVKIDNEKAESGDLEADWDFLPAKTIPDPDAKKPDDWDEREKIDDPDDTKPEDWDKPEHIPDPEAKKPDDWDDEMDGEWEPPMIDNPEYKGEWKPKQVDNPDYKGKWVHPEIDNPEYEADDKLYSFADFGAIGFDLWQVKAGTIFDNVLITDSVEYAEEFGNETWGKTKDPEKKMKDAQDEEDRKAREEEEKKRKEEEDANKDDEEEEAEEEEEEEDDDAAPEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0J9Y6</accession>
    <name>A0ABM0J9Y6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005088846.1">
        <property type="nucleotide sequence ID" value="XM_005088789.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850682"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005088846.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="47215" checksum="70787D959E131A5B" modified="2025-10-08" version="1">MAPNNPLTVWGNEKTMNLNPLILTNIQSSPYFKVQLFELKTFHEVVDEIYYKVEHLEPWEKGSRKTAGQTGMCGGVRGVGAGGIVSSAYCLLYKLFTLKLTKKQVNNLITHRDSPYIRGLGFMYIRYTQQPQDLWDWYDGYLDDDEELDVKAGGGHFMTIGEMLRQWLVKLEWYSTLFPRIPVPVQKDIDMKMRSRPVAAGFPEYAEQEVGADEPEHIPDDELSFGEAERAALSQRGRGSASNGRREDSHNGSSTSRRSPPPRRGSPPVRRPSPPGARRSPRRSPPRRSGSPRHSPYSRSGDDFSRELERERDRQRKEKEDYKSSKSDKRGSHSKEKDRKRSRSRSHDRKRSRSRERKRSRSRDRERRRSRSKDRKEHSSKHKERRKEEKKKSKHKDKDRERRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA02</accession>
    <name>A0ABM0JA02_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Metalloendopeptidase</fullName>
            <ecNumber evidence="14">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC101856539</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_005088874.2">
        <property type="nucleotide sequence ID" value="XM_005088817.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856539"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0420">Kringle</keyword>
    <keyword evidence="4 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0768">Sushi</keyword>
    <keyword evidence="7 13 14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045008835" description="Metalloendopeptidase" evidence="14">
        <location>
            <begin position="30"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="21">
        <location>
            <begin position="163"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="20">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="16">
        <location>
            <begin position="657"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="18">
        <location>
            <begin position="777"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="20">
        <location>
            <begin position="848"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="19">
        <location>
            <begin position="899"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="17">
        <location>
            <begin position="964"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="20">
        <location>
            <begin position="1086"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="794"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_005088874.2"/>
        </source>
    </evidence>
    <sequence length="1357" mass="152200" checksum="72D2B0C95CD465C0" modified="2025-10-08" version="1">MKPHRPSVYVQPSLCVLFLLVISFTSVHSKSKRSQDVIEPVDEGRVQERRDLEHADEGLSALLVAAFEHRERELEEFYRDVPDEEDVEPDPNTDAQSLFAQIRSEAIDSQAQAYSLEQKSILTEKRRKRSERKRKRFLDRLTGQANDPSKTKRGNDAKIRNKRVVQSEEKRVWTEGLVPFMFTDEINNVSAIQIKRAMSTFQRFTCLRFMPWSNETGNGTQTTNDVLALDHQSYLKFVNGPGCWAEQGNRRSPSGQEISCCGGLTCIHELGHATGHYHEQQNRKGVGIVRLNRFNSLEKYKFTFEYAPKDAFSTGFDLQSVMHYGPTLWTRNGNETNSVLFSDLPSGSEYFYLMEEVSLAHNCHGMYCSEFDKTCVNDGYVTTVDGTCNCFCPKDLDPSTGCATVLKAGSFTGGFPGGKYALPAPIGGCPDSAFLEGARTHFGEAAPCEDASSYCSYWAKIGECERNPGFMVTTCKVSCNLCYQTESFTSKSYHLAGTVSGARVEHEFCVNDGNAISSKQMWPSGRYCIFRYGDSCPEGFENGTVEFPDVNNSSSSVIGEVPAGVYEEDLTVFEFCCRQDGFDSDNLYFPTDKPFALLQFGMGCPAMEAMRAIPEYMVFNSAGKAKITGITPVLEYNEENTQYIIRHCYYEAVNMDCGGVIELSPDKPSETIVSPTGANMRCTWLLKGGEGTRLLLNFEKFNITKSGKKCEDKVSLRYNRLGQKPVEYCGDNFAKSISTVYNTLMINFETTTQDTSSFEAVVSLIHPDTMCYKADDKGASYAGQVNFTRAFKPCLPWYKVMECNHGAFEYPDVLGNLEENYCRNPGDGVRPWCYTELHNCRRDYCDVCFDENRYDVHVDCDLLAEMGMCENDPRALSTCAATCESNLQSFTEPPIASTVSCSPPDPLPDGAVVGTLKDSYSMGEIVTYQCDKSNMTQERTCLSNGMWSSLNYVCQECYKDWKLYDGHCYKYFEDALKYSEAEIACAAFGGVLTTAKSEEENDIVSSVRMDEKEVWLGGSDRVTEGEFKWGDEEPFDYTNWLKDQPDNFYNSDCVIMKADKSWNDIACEFYSKSYVCKHKQFEVKACDDVIEDCVNLNYYDPVACTSQAEFMHRNCRRTCGLCKSISCTVEQPSENVELLSDLTEVPQGSTVTYKCKDGFVAVAGNTVRGCQDCGLMTGDTLKCVAQESVEVTMDSPPLEKPKMSGTPRRAFTGNVPYMRVPIDGHIVRWEFFSSSYGDGAFQVWRSFGEGNFTYQLIGQNPVKTVSDFQVNYYVPEADRIPVRKGDLIAIYYGNDYAGIGYALCSLADNPDYKNLGYLKNPITSAADFEAGNYYEFAPLDASSACRQYIFRAVVLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAT3</accession>
    <name>A0ABM0JAT3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase-associated protein CTR9 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101856767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089414.1">
        <property type="nucleotide sequence ID" value="XM_005089357.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856767"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="895"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="840"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="895"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="982"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1188"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005089414.1"/>
        </source>
    </evidence>
    <sequence length="1197" mass="134990" checksum="CAEF55848D3DBCFF" modified="2025-10-08" version="1">MASTSGGGSRSIEIPLRDTDEFIELDLNTLLDGEEVLSILKQEVAPLHIWVTLALEYWKQGAVEHFEKILEASRTDASLDYLNCEKDQMRSLDTLAAYYVQKAHKEKNKDRKRELFTKATLLYTTADRIIMYDQNHLLGRAYFCLLEGEKMDQADAQFNFVLNQSSNNIPSLLGKACIAFNKKDYRGALAYYKKALRTNPTCPASVRLGMGHCFVKLNRLAKARMAFERALQLDSQCVGALVGLAILELNSKAQESIKNGVQLLSKAYTIDSSNPMVLNHLANHFFYKKDYQKVQHLALHAFHNTENEAMRAESTYQLARAFHVQEDYDQAFQYYYQSTQFAPANFVLPFFGLGQMYIFRGDNENAAQCFEKVLKAQPGNYETMKILGSLYANHQEQDKRDIAKQHMKKVTEQFPDDVEAWIELAQILEQTDVQGALSAYGTATRILKEKVEADIPPEILNNVAALHFRLGNFEDSRKYYEASLDRSKKDAQHDETYYSAISVTTTYNLARLYEALHEYDKADKFYRNILRDHPNYVDCYLRLGCMARDRGQIYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILQRQSTKDDAYCLIALGNVWLQTLHQPMRDREKEKRHQDRALTMYKQVLRNDPRNIWAACGIGCVLAHKGCINEARDVFAQVREATADFCDVWLNIAHIYVEQKQYVAAVQMYENCLKKFFKNHNVEVMVYLARAYFKCGKLAECKQTLLKARHVSPNDTVLLYNIALVQQKLATMILKDEKSNLKKVLIAVRDLELAHGYFTYLNQHGDRMKFDLAQAAAEAQQCSDLLSQAQYHVARARKIDEEEKEIRKRQEEEMEAIKQKHQTDMMEKLKQKEEMERKMLEQRAVFVEKAKKINLEPEAEDRPRKSGGKRSKRAEDGEILSEGSEEERPKKKKKKKGSSSGSEMDDDEGDKKRKKKKIKRKSKKDDFVNDSDDENEDRDRKRGKKKKGKEGKAEKKKKQKEEDDGLTAKQRRKIVSKAVISSSEGSDSDTRKKRLQDSGSGSEDNAAKGKRRRIIDSGSDSDAGGGEGGKKSGSGSENEGQRRSRSGSRSGSERKSRSRSGSRSSGRSKSRSKSRSRSRSGDEGNKSGSDVGSAKAANSDGEGSGKEGGGGGRSGSDGEGNKSGAGSGDEAGGKSGDEAGGGGSGGDQAKSGSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDF8</accession>
    <name>A0ABM0JDF8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein glass-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101863158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysioidea</taxon>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
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            <begin position="401"/>
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        <location>
            <begin position="485"/>
            <end position="511"/>
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        <location>
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            <end position="204"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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        <location>
            <begin position="117"/>
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            <begin position="168"/>
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            <begin position="242"/>
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            <begin position="260"/>
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            <begin position="278"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDS1</accession>
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        <name type="scientific">Aplysia californica</name>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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            <begin position="45"/>
            <end position="72"/>
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    </feature>
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            <begin position="65"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFE8</accession>
    <name>A0ABM0JFE8_APLCA</name>
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            <fullName evidence="3">Ketimine reductase mu-crystallin</fullName>
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            <ecNumber evidence="2">1.5.1.25</ecNumber>
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        <alternativeName>
            <fullName evidence="17">1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">NADP-regulated thyroid-hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101859463</name>
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    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Aplysia</taxon>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58517"/>
            <dbReference type="ChEBI" id="CHEBI:176873"/>
            <dbReference type="EC" id="1.5.1.25"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:12506"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12500"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58517"/>
            <dbReference type="ChEBI" id="CHEBI:176873"/>
            <dbReference type="EC" id="1.5.1.25"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:12502"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lanthionine ketimine + NADPH + 2 H(+) = (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68040"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176891"/>
            <dbReference type="ChEBI" id="CHEBI:176892"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:68041"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-cystathionine ketimine + NADH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:68032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:176808"/>
            <dbReference type="ChEBI" id="CHEBI:176810"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:68033"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-cystathionine ketimine + NADPH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68036"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176808"/>
            <dbReference type="ChEBI" id="CHEBI:176810"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:68037"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Delta(2)-thiazoline-2-carboxylate + NADPH + 2 H(+) = L-thiazolidine-2-carboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176895"/>
            <dbReference type="ChEBI" id="CHEBI:176896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:68073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61185"/>
            <dbReference type="ChEBI" id="CHEBI:77631"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:30809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12524"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61185"/>
            <dbReference type="ChEBI" id="CHEBI:77631"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:12526"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-proline + NAD(+) = 1-pyrroline-2-carboxylate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:20323"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-proline + NADP(+) = 1-pyrroline-2-carboxylate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:20319"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Binds the thyroid hormone triiodothyronine (T3); T3 binding inhibits enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.1" evidence="16"/>
    <dbReference type="EC" id="1.5.1.25" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005092454.1">
        <property type="nucleotide sequence ID" value="XM_005092397.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859463"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005092454.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="33544" checksum="548D4C26ADD0EF0E" modified="2025-10-08" version="1">MEGSQEHPLFVSAESISDCLEFKDLIPAVEKGLATFSRRSGDELIQPLRTVMTFPESNGYFASMPVYSKIDDIIVTKMVSFFPKNTDVPSHNAVILVFSTKNGLMRAIMDGDVITLKRTAAASAVATKYLTNGQPHTLAILGSGSQARSHYAAISHVFKFQQVNIWNHRSAGAEALAKEIGPTAQAFASVEDAVRDADVIVTVTSSDKPVLKAEWVKPGAHINAVGACRPNWAELDPQLMQNSVVYADSREGAMSESGDVIMSKATIHAEIGEMVNDPTLARPAETTVFKSLGVAVEDASAAKIVVDKLKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFI8</accession>
    <name>A0ABM0JFI8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101850144</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="RefSeq" id="XP_005092505.1">
        <property type="nucleotide sequence ID" value="XM_005092448.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850144"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="144"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005092505.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="56740" checksum="C57F0AF4C90DF488" modified="2025-10-08" version="1">MATTDSKMSTTERIIKSVPFPPSHRVSMSEAFDAKGKPRPDVLKQHFILEGRVTEDVALRIINEGAALLRQEKTMIDIEAPVTVCGDIHGQFFDLMKLFEVGGPPASTRYLFLGDYVDRGYFSIECVLYLWALKILYPTTFFLLRGNHECRHLTEYFTFKQECKIKYTERVYDACMEAFDCLPLSALMNQQFLCVHGGLSPEIHTLDDIRKLDRFKEPPAFGPMCDLLWSDPLEDFGNEKSSEHFTHNTVRGCSYFYSYAACCDFLQQNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAILKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVSEGDADSMEGDGANKSKSQANFDLIAARKEVIRNKIRAIGKMARVFTVLREESESVLQLKGLTPNGLLPLGALSGGKDTLSSALSGFSPNHKISGFEEAKCLDKMNERMPPRKDAVNSNNKEHQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGJ4</accession>
    <name>A0ABM0JGJ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E3 UFM1-protein ligase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFL1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093191.2">
        <property type="nucleotide sequence ID" value="XM_005093134.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850149"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056761">
        <property type="entry name" value="Ufl1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056580">
        <property type="entry name" value="Ufl1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23659">
        <property type="entry name" value="UFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25041">
        <property type="entry name" value="UFL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25870">
        <property type="entry name" value="WHD_UFL1_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like" evidence="6">
        <location>
            <begin position="561"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase-like C-terminal" evidence="7">
        <location>
            <begin position="687"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005093191.2"/>
        </source>
    </evidence>
    <sequence length="809" mass="89933" checksum="C3F199A2411EB4FF" modified="2025-10-08" version="1">MFTYCLTAKRVGSLRLNVDNMEEVWKLAAEFQALQLSTAKQKLSERNVIELVSKLVDFRLIDVLYTADGKTYLTHQQLGKEIKDELIIRGGRINLVELQQLLNVDYSHIEAKVNDMVKHDHHLVLVLGQLIDSSYRTRLSEEINDLLQEKGHVTIIELTKTHDLPAEFLREVIEENLGKKIKGQIDSYDRDVVFTEVFVRRKRAEIRGALSAVTVPTTLGPVRQAVGCQEHLFHTILEELLSSGRLAGGVMGSRQDKSQFLPDIYTRAQHEWVDSFYRQNGYLDYDAIARLGISDPKSYVKKRFKSETMVFLSSCCVGPAISEQVQYSLDEALGLGTYVDVASVLPSVLSRKDVSELVTSCLKSRSGAIVCDMTIVASESLVADSALLFSDIMAQKAEKTVLSHPTLISGEATGGAGDKSNSHKVAGIDDGSSAREDKKEQRRKKAASAGTTKKEGTGGREVKMKSTKKKGRGRDIDDGSDEDMAAPAQGSKGKQQELQFLSVAEITKVLREQERLKDCPEELLTEVASRLHRPLQKQYQEVAKSIFLKTSGAEKKKTAGEIQDKVNGLWTNARLFEKGLKLFEEPAQGQLTKHLLKTVGSDLANTVVVALASDSLLNVANNEEEQLTPEARLRLIGQLPKELQEALSRLHGLLSGQSLEDFFSQLETLCGPAHLGILLKKPDKRKERQLVFHHRQSLSEQLREETDPAMTLHLCVVVLFQTVTQCMLHAPGRLVPTILQFLTTHLEADKLEVLTQMQDLVVRHAKLKADPDGENLPEFKDVANSMTVLLGKVKDIALNTKKTTSTADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI96</accession>
    <name>A0ABM0JI96_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101850549</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101850549</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094253.1">
        <property type="nucleotide sequence ID" value="XM_005094196.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094254.1">
        <property type="nucleotide sequence ID" value="XM_005094197.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850549"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021084" evidence="1">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094254.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25380" checksum="56B80284C9528B97" modified="2025-10-08" version="1">MRMFQVILVAVFIAGYAASDFHDENQQCESSLQTCAFPVAMKFAPHTESEESFISYVQSIPVNTVCTVVMEPFMQCVQTALDTVCAGSNSYIATEASNFLGVISYACGPAGRLVLESMKQSPCLNNAYAFEAAGNLVEMCQSVTYAQVEPQLEQSNDQETRPDPAIVCPLLAEMRACIVGGLGSICGDAFEEFFSQIWANLRLSMTGQYFDCGEGLKRAAIFKKRNLGSIFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJH5</accession>
    <name>A0ABM0JJH5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Germinal-center associated nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101859920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095086.1">
        <property type="nucleotide sequence ID" value="XM_005095029.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859920"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031907">
        <property type="entry name" value="MCM3AP_GANP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16769">
        <property type="entry name" value="MCM3AP_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="478"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="566"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1090"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1985"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2060"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1859"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1090"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2075"/>
            <end position="2086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005095086.1"/>
        </source>
    </evidence>
    <sequence length="2130" mass="235681" checksum="83183E80AE57EEFC" modified="2025-10-08" version="1">MDQTNSVFGTFSAPVTSSSTAAFGSTSGVFGGSFGQAPVFGSQNLFGSASSTSTSSFPVPPTTGGQQSQSRVINSTSSVTSVFGAQPLFGAAAQSSGGNTSSSVLGKSTQAATTASSVFGAGFQTSQPTNVFGSGSTFQTSSMTSSGKSFDTSPFGQTKSSLFSVPASSGFGTFQTKSTAVSVFGGVGKNEKSSPSQSSLFQTGKSTTASGFGSGTFSISKSNIPFGKAATQLTSAQHSALFQKASGAQSVSSAPQNIPSLLSATPKSILDPQVAGDPDKPRPTAVGLPMVKMEKTKGTGSQGHQLLQSTNTDLQKQNLFKAKETSSLQPKSLFGGTKSEVGVKVSPFSTQGPSSSTSSSKPESNLFGASQKSSVPSGRVSLFGKSYNKEEDQGVEQAHSSSQNSPRKTLSKWNRSRDVAGPTDRKRRESEHEDVERDPTEVKRSRTADSTSGTDGSGSLTLGRARTTRKSVEDTTRMSIIVKDIPAHLNKGTILRRHFSRFGTITRLLPVPSKGSANITFQSHEEAAMAKSKGRQLEKGGPQLQIFWRASGSSVKSPEANKPFRLAVAKDKRSPSKVSLSSVPEGSVEDELASMAGTADVQYEIGPVRKAPKEQKKTSREKPRRRSPTPPPSAPAPTVVPASTSDLDVAKGLLKTLWGSRAPDSSSKINVLDARDKLLRLLRGRQQSDLASAKAFAGDCPDLCPEKERYYREDIRRLALYEVIPETLSSLTGLKSEVDHYRAVKEYSRSSADQEEPLPHELRPLPVLVTTMTYLLTEVADEGGEGKWAEWYDFLWNRTRGIRKDITQQQLCDIQVAELLEKCARFHVFCSERLCEEDMMSFDAKINDENLTKCLQTLKELYADLENKQGVFCPNEAEFRGYMVLMKLNEGDILREVQQMRPDIRESAPILFAVEAYNALNSHNYVRFFRLIQRASFLNACILHRYFIQIRSQALRIIMKAHGALGKNKIMYPVAEMIRLLRFESAEEVEEFCYHYCLSVEESDVLLDAKAYMEPEGSLSQRRSQTLVEAKCTVSVGETINGCPLPMLILPTPSSSFDENGKFIISNELKAALYSSGLKLQPSAADLMQQAAAAPLPQQSLQEPQGRSDDGGGRGGGGQSQGALRGPSQLPDATAMARGRTAFSNEDIKNIARTVILEVIDTATLDIAREVMSEQKEQDAVIRTVFDDLSADVVQSLTRSLAKEVHNEEESRVQQARAKEMAEQRQRVFNVLCEDIVEDAVNDIVQEVAINQMNIVTRELNRQCMEGMSLSCQDSLLSVVTLEIAQDIAQEVFEIDVVAKRERLEETERCVQLMRCRRVFQFWRSSYLSRVRVKRAMLDFPSAPPTRKTGEQLMRLVPNRPDTRIVNNSFFINERARLYVSSPMDVIQQQLKLTASLSMASVHQMLLGLRMWQPLDIVQTLGTQLHRAFAQWREADCIEPDCDSIHWKLCMSVPNKKLCQDEEQKKFIDWLRAKLCKDGDRDKLLEETPGYQGEVLSLYHCQLGAQRARGPTLRLCVRCFHGHWNDTHELKVLKEGVLKGCTGVLFVTSPVEQLMEDQNLWQQDKRRLHQVLKQKPKVPAVPLVIILPRRSARVTVAVSEVSQHLDLEGLGQGQRVSAVHLAQPYVGQGRQPADCYNEWTEQLSNCLRFTASHIPTPARLRVKPVSDFVEDTVVEMYKAPVYQDLRTRHRHQQLHQSPNVLVSLYNTVIEHTAMVCASSSLTDLSWPSPEFDSSASLALGEPLSSWNSESHLSDLYELVSRLRLPVFRYQDLEAQDWTSVCQDVWNFVALVTKKDSGSAKISLHHQVSDLLTYAKKTFDQFCWLASEDGPCEPTYVNMAWTDLIDACIHYKLVSLRTGHLRIEVERDEDEEEEEEYEEAVVFYKEEELEDWEAPVAWVDALRDTETARAGQIKLTVVESAVKRDQSLLEASQMKDTLSSAGKDCHSPQTDAEKLSPSWRDLKERFAQERAKLDTFEQSLSSKLLQGPLPANSTLSPIPLPKESLSRFDPGSGAMSGQRARYASKATTESQEKGHGLSQGQRFGFVNSSRSLEAFTPNIKSQARSLLSSGAKDTEKMDEDTTDTEEEKGEKYELTLTEGVSNLQDLVEEQRRADRLFEMRLQRLMNPTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKB6</accession>
    <name>A0ABM0JKB6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005095719.1">
        <property type="nucleotide sequence ID" value="XM_005095662.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848508"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF8">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="6">
        <location>
            <begin position="168"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005095719.1"/>
        </source>
    </evidence>
    <sequence length="812" mass="92752" checksum="316C1FF889B32E2E" modified="2025-10-08" version="1">MSMRNKPGLSFVLVLVVCLVILYFSWKSLLAPKIAPQFKNVDGGLGWKGIFEGLKDEHPWFKEKPQAENRVIDVPPRKTNRVQPSSHDVRTKAKSMKNSPASKSAVQKPSANDPHYQAIDISITDILKSMNRFVHLDLKGAAPKISYFKELFPLLSKMGATGLLIEYEDTFPYSGSLQGLAARNSYTKADIMQIQSLAKDNGLEIMPLVQTFGHMEFVLKYENNEKLRESAHTPQVIDSNSKASLTIISEMIKQVLDAHPRVTRLHIGCDEVYELGRGVSADVMVKENVTKERLFLRHVKHVATMVGNYRTGGRSVTPIMWDDELRGITFEDIRDSSLPSLVQIMVWHYTRNILKKIDDDVWQKYSLLFPRVWIASSFKGASGARQFYTNPSFHIANHFSWLKIIARYRDMIQFSGIALTGWQRYDHFATLCELIPAAVPSVAVCLATMKYGGFTKDIHRSTSDILRCSSLLEMSVPVLDPKTRNAQVSQDCRFPGSPIYYALQEYYGYFKKSDKTKQRLIGWLSDYQVAHGFSNPGLLKGLKADLTSQTSNFLKISTPLKEELKAIYSEDTVDEWLEENIFERIRENKNNIMRLDKLLNTTSWKARPFDRIDVERHSKMVVKTDDEMKSKSVKRSTSPTYRDREVVLPSGGVDDGRKKGKQYNSPEVKAAKRVENQMFALQGNNMRSKYISGSERRTPPKESPPFLPKNRLEALIENHDTRKKQFDMRMDSNNRVEQADEGIVNKRVAAEKKVGKRVSDPRPIIDRSKQGPKKSLQFVQVLKDTNAKGINNKDFEDEKMNSYESRLLKMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKH0</accession>
    <name>A0ABM0JKH0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101854317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101854317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095831.1">
        <property type="nucleotide sequence ID" value="XM_005095774.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854317"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055470">
        <property type="entry name" value="DUF7042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055471">
        <property type="entry name" value="DUF7043"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055472">
        <property type="entry name" value="DUF7044"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF1">
        <property type="entry name" value="LD32918P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23069">
        <property type="entry name" value="DUF7042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23070">
        <property type="entry name" value="DUF7043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23071">
        <property type="entry name" value="DUF7044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045978344" evidence="1">
        <location>
            <begin position="27"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7044" evidence="4">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="2">
        <location>
            <begin position="150"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7043" evidence="3">
        <location>
            <begin position="298"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="2">
        <location>
            <begin position="437"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005095831.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="74177" checksum="C4180393E2DAD845" modified="2025-10-08" version="1">MAFPNMGAFTMLSLVVLITLFHGAYGQACTFHESHHGDWYSMEVGRDTFTLVSEEKWGDYTCVRKHEHPSQVANEFQKGINVTMLIKESDTCFACLDVLWRTENILQYRKSGCFSSNSGFESLCKGIRKLPSQNEVITLFRQTLKTVNCIDTWEGVYQFTYEVNWGGGGICDHPDNRLKACQDPGSVYVDNQVFLMTYARCPGVQTSKSETIRYQCMGSWYALIDGEGYTFASIADTVEKDTREKYKCLMTKRDQKQEDNSISWGMSRFADCSALNSVYSSPVRLRLHRVPPQTPYVAPQCSMPRNISGEWFTQGIQFKSRVVVNETHFHYFTQKNKFEYEETYLSCQQTLGTRYLMTKYIVGKCEVDFVCYDILPRHHGIVRYRVGKPSRLTDDEIADPTFMVKKFREVCSWQSFTFNRNDTDWKYEVLILDPPSPVTCPVAGRYSFVQNANGFLEKYMTRIRGVTVKPRVQVNCRIIVSELKSCSQDRSRIEIDEEYCESVDYRGRPIGEYDEPDHILTCVGFWMEDMKSYMITYDEEDAISRFRCWVYERISWTELSLSRSQTARCQRAQNATSYMLEGTGLQMVLTENERLFDDCPQRFDPGLNPHMRPTVIYVLSSAPQISSLGVLAIFSAFLVASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JL75</accession>
    <name>A0ABM0JL75_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Partitioning defective protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096318.1">
        <property type="nucleotide sequence ID" value="XM_005096261.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849919"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF11">
        <property type="entry name" value="LD29223P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="157"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005096318.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="41534" checksum="02CAFFC964C7FD18" modified="2025-10-08" version="1">MAKSSRSAFRSAGGIVEIKSKFEAEFRRFSIDKNKTSQFDEFYLLLEELHGLIDTPFVVTYTDPVHMDLLPINNNENFIKALTTARPGLKVILQKKGESYGELYGYGLQPVKRRNPISKLMSGEPAARPRIKISVMEDFRRVSAIIDVDIVPETHRRVKLMKNGSDKPLGFYIRDGTSVRVTPQGLEKVPAIFISRLVPGGLAESTGLLAVNDEVLEVNGIEVAGKKLDQVTDMMVANSSNLIITVKPVNQHMTLAPQRGAVGRHSNMSSTSQISHQSQASNISYHSAKSFDNEPVPEVDDEDEIHDHLSPTATEPPTSIGESSSKDNKSSASDPGFVKSENSEKGASSNNNNGSKAKREKVKNSEVEKENDDPIVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN56</accession>
    <name>A0ABM0JN56_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Colorectal mutant cancer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097587.2">
        <property type="nucleotide sequence ID" value="XM_005097530.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846813"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040171">
        <property type="entry name" value="USBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019536">
        <property type="entry name" value="USHBP1_PDZ-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347">
        <property type="entry name" value="COLORECTAL MUTANT CANCER PROTEIN MCC PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347:SF6">
        <property type="entry name" value="FI17904P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10506">
        <property type="entry name" value="USHBP1_PDZ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Harmonin-binding protein USHBP1 PDZ-binding" evidence="3">
        <location>
            <begin position="287"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005097587.2"/>
        </source>
    </evidence>
    <sequence length="394" mass="43896" checksum="5F8FF541FA724E2B" modified="2025-10-08" version="1">MGVLLANCRAAGLGGFAVTEGEDDLEVTSILQRAHHARRRAESVARLLLSRLDRSCAGHMTSSGGCQPWEDVSTNSRTASTSSTSSSTELDFAKTDELRLREHIQQLKTERSAVRTTVMELESAHVDPLALEPRGRVEAQRLDLENAVLVQELMAVKEEKAELKARSYLLEKEKRALELRLSGKETQETAYRIQIEHLQGELELVAGEHPPHAPLTSPSPSSPRSGASGHQYHHHHQSSRTTTASSKQQQQQQQHLPDAWKVTEMASRDANDLARDFLLSLERERVLKWRVSELMSTLEKISRNSESGHKQWAQFVNDLKRANSALISAFDKARKKYQGRLKKMEGQLKGWKEKYDADTAALRQRLSVLEGTRGGGGGVRTPPTPQPPPSETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNC2</accession>
    <name>A0ABM0JNC2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859099</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097723.1">
        <property type="nucleotide sequence ID" value="XM_005097666.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859099"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045313677" evidence="1">
        <location>
            <begin position="26"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="H-type lectin" evidence="2">
        <location>
            <begin position="228"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097723.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32072" checksum="308676C8224962AB" modified="2025-10-08" version="1">MNSGNGLSSLGAVVLLSCLLVTISGSVIVLDASSDVIEKNLTRTATLRCSLDDTTSSLTAPVVGRRDITQTATNVEYVTSIIVTRDTGEIVARVTEHETAEALVDQASLRVFGNLSVTSGRRGYMELTWKFPTQRQAGDYKCEVNAIDDNGHFVTFSTSLKVNVTTPSVEDVVDQLHVTSNTVDRLANEVAEMKSLLANFSGVQHVEAGTLKCGYPRYEYYVDDQILTQKFRSPYDKPPVVTLGVTVVDFGDIYEDAQFDVSLVSVDEQSFTIQCEKGRGYNAYNMTVSWMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNZ1</accession>
    <name>A0ABM0JNZ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852094</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098123.1">
        <property type="nucleotide sequence ID" value="XM_005098066.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852094"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047396143" evidence="1">
        <location>
            <begin position="23"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098123.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="55041" checksum="BBF3FE369E05EF4D" modified="2025-10-08" version="1">MTFSAPVWYTAWLCLAVTQVSADINSGCPTWGCLSWGSFSLSAGVPSSNGQVKWSKAIEQIGNAADVGVVGRGCISNQDFVVCTTQRGYVSLDPSTGEQLWNYTAMSNPYLPLMDVYGDVIGIDKNNLVYVSNDGTPKHPIGIKIMQPDFGVMVSNNSILFLTATKTETAQIFTYDTDGIIDAAFTLKGSWERMNGTFVPCSHPVIAGNRAYIVTKFIPDGANTTTKLAWKRLFALDLLHQMAPRIVIAWYANFLMEGGAQDSMPSTVSSTQPQPVPVEEQVPIVTYFNNTVYINMIWPNKVSKREPYDSKLWAFRDEGAYASRLFNASSFYGPMAVFDTYDEPIKFRGPRKAERFHMVWVSSNSPAKLTGYRTQDGAVVQVIDVGMVSKLGPNTTITSKLSITRQNTSSNRDTIVLGAVDANKQAFLLAIEADPANAGSSLLWATKLSEQRADPSTWAVEGQVVNTAQPIPGTGGSVDFKLGLIAMVTETGNDYKKTYIKGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPF5</accession>
    <name>A0ABM0JPF5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 178</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098448.1">
        <property type="nucleotide sequence ID" value="XM_005098391.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848885"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038826">
        <property type="entry name" value="CCDC178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35088">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35088:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="744"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098448.1"/>
        </source>
    </evidence>
    <sequence length="978" mass="112447" checksum="B1B9F1C158E1AF13" modified="2025-10-08" version="1">MSRKSMSMAGTKVVKLEEVEQEEAGLLDTDRSLLKSVIKKTSICDDSQRGNSRSTSAVHSKRGSSVSEAGTESGCVDESEAEDKVYPLPENWPKISLLKLRPRSCELSLSRMPCVKKAVSHIELIQNIIDEWFKRLTEDIKSRASSRHSSAHGVKKQLRFQDLPDETYVSSHGSPSYKGSTVSRASSSRLSGSTAELSVTGKGTHQVEEVEEEVIDVEEIPYLGAQDVIDEVITLLARLESDRQDTQENYMKEIEKAEKLRQKIDEWQLKRMRELPSLVQREHEACIVDLNELHWHVSFAKRNEAKAQTRFSTAERLNTQLKEDIAFVKQHVPLVQEKLILEMEAMEKIRKAQGETDQELVMTKQRQAKTEMKSTEALTKAETERGHIKKELDSVRDDLTNISEELTEAKMTYNAFVHQVNDIHSQLTDNDQELKVLRVKNENARTAEEMQATKVRDLQAKITEAEFEHRRLENENEQLEQELKMNKNRNFHKLQDLERQLKALEAKYRIVSRKNQELSMEIEDCEEKIKKCDRQKTADEKNINRINREIERTASMLHHTMEEHHRISTVNHHIRDQLSSEQDKAFRTEETLKTTTETLRRQVKDEIHTRTVLQARINSDTAEIEKVKTESAKKKGKAKSVADDVEQAVSGVLQKVEQLRVAKQEKEQRMNDLKSKLEETQNQHQESSDRFHQTLGRIEPRHQMLTAEVSDLTKKLDHMEWRTQLMKNKMEEMDAAQGMMERSVRTSEQAITTLTAELDELNLQIEAGKKIEEDLRKQYNETLERLRGNENKHGNLLKDRQDVLKKHEVDKARFIEKNKELASRYRQLQNDYVICKEQMLRSYDERVKIEATITDVKQLKSLQSKLHGALAEYFKLSGLYNEAELSKLEQESSVNGVRVSELQLNMEHALDDISEFISSQMDGKVARQMAWDAVKRKSVVDAGDLGLGDGLPATAATTLTKSTSHLGSRQVSQVTVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPF8</accession>
    <name>A0ABM0JPF8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">THO complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101854170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098468.1">
        <property type="nucleotide sequence ID" value="XM_005098411.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854170"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12680">
        <property type="entry name" value="RRM_THOC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005098468.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="27610" checksum="636E409494E62697" modified="2025-10-08" version="1">MTDKLDMSLDDIIKQNRRGRGRGRGAGRGSRGGPGGGGRGGRGQSRGRGSGNAGVFRGGVNKRRGGGSFNQNQRSRDVPNDVWQHDMYDGGSAPLRRGGGGGPPLSGGQGKLLVSNLDFGVNDSDIQELFSEFGPLMKAAVHFDRSGRSLGTAEVIYQRRTDAVKAMKQYNNVPLDGRAMNIQLVGAVSRIGPTRGGGGGGGGGGGGGGNSGGFGNRQGGGGGFRGGRGGRGGGRGRGRGRGGREKQEVPTLEDLDAQLEAYNAKMDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQB5</accession>
    <name>A0ABM0JQB5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101846504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099040.1">
        <property type="nucleotide sequence ID" value="XM_005098983.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846504"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="142"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005099040.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="63066" checksum="38D78C9FFA957416" modified="2025-10-08" version="1">MTMEHLVGMFGPDEQDDQSEEMDELPSALPPEEEEGNIEYKLKLVNPSEFRVEHLVTQMKWRLEEGHGEAIYEIGVEDSGFLAGLSDEELDASLSTLRKMADRLGASLEILREKVIEDDIDSSITRRALEVLVRKVPDDQQFIDLKLAVLGNVDVGKSTLLGVLTQGELDNGRGRARLNLFRHLHEIQSGRTSSISYEILGFDGSGQVVNYSACRSVEEICEKSSKLITLIDLAGHHKYLKTTIFGLTGNCPDFAMLVVSANNGIVGTTKEHLGYALALDVPVFVVVTKVDMCRLAVLERTLSQLEQILKSPGVKRVPIRIKNPDDAITAASNLESRQITPIFTVSCVTGKDLDLVKQFLNILPPVTPHCEREKLAQDMTEFQIDELFSIPDVGTVAGGIIQRGSIREGDQLMLGPSDDGSYRKVKVKTVHRNRLPCRLIQAGQAACVALQDIEREAVRKGMVLVSPQSPLYSCLRFEADVYVLFHNKSITVGFQTTIHIGTVCQTAVIRDIDRHHIRTNEKAKVTFEFKFKPEHLRVGSRLLFRDGKSKGMGEVTKIIPYDDVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU04</accession>
    <name>A0ABM0JU04_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101854876</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101854876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101454.1">
        <property type="nucleotide sequence ID" value="XM_005101397.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854876"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005101454.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15281" checksum="EA12EEA11B18CC19" modified="2025-10-08" version="1">MVNKFLVQMDNGYADHRDNSYMDIQHLAQQGEGPLSRHKRSITLPSNVTFDLVKEGVFQSQDTVGVGHRIQFKLDILFPAGDTDIQTFTPEFNLSGPDSLPVGGSGLYTFEMTLPFVKKNVQFDVFAPINATVFPAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUI8</accession>
    <name>A0ABM0JUI8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium and integrin-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101818.1">
        <property type="nucleotide sequence ID" value="XM_005101761.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860261"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0401">Integrin</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101818.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20930" checksum="E02458FF1C4E10C8" modified="2025-10-08" version="1">MGGSQSVFTEEELDDYQTLTYLSKKEILHVHKRFKAISPGLVEADKNAKLPFTKIRELPELKVNPFRDQICKVFSSSGDGMTFEDFLDMMSVFSDGAPKNVKVEYAFRVYDFDGDDLISDEDLKNVIECLTGANKLTEDEMQQLIDNIMEEADLDDDKTLSFAEFEHVISKAPDFVNSFRIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW38</accession>
    <name>A0ABM0JW38_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Protein dimmed</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101864536</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102880.1">
        <property type="nucleotide sequence ID" value="XM_005102823.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005102883.1">
        <property type="nucleotide sequence ID" value="XM_005102826.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864536"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19712">
        <property type="entry name" value="bHLH_TS_dimmed_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF167">
        <property type="entry name" value="PROTEIN DIMMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="79"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005102880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005102883.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21266" checksum="379AEF7864A53DE9" modified="2025-10-08" version="1">MDLELNDDLSFSSSMWEETEAAAEFGIRKRGGTGGKRDNPGSPSDSSSSNMDEPSEKKPRGGKKSTRRRKGVSAKERNLRRLESNERERMRMHSLNDAFQGLREVIPHVNLDRKLSKIETLTLAKNYIKALSNVICNMRGETPPYKFEDAPPSNDGEEWDEEDNEGSEINVESLRQSSHSSSGSSLLDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW39</accession>
    <name>A0ABM0JW39_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101845480</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102884.1">
        <property type="nucleotide sequence ID" value="XM_005102827.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845480"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102884.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33490" checksum="CA3F9CF3A4AA1BFF" modified="2025-10-08" version="1">MLDTAALIERLEKLPQRSRHGSKDALDERHGHMGLRFRQNKSAEMLSLGVTPGFVTPSCMAAITTPTVSVATNSRELVTSMSLPHGMTPGLTPRLIAIHSSAHVPLRGILKRPSSEPTLFTPSLTETMIQARAKRHIQLGKVRDQPGVKSPDLENTSKLYDARGSQEMGSLETEQSVSLVVSKCCNSFDDDDSNSVSLSVPKTSNEMAKLNSAPPATSEQRTETHSISLHTKMDFQPQYNTEPIEMLQGYSTYMTMHSDRVNQSELGARATDTCHTSCSSQSEDRALNGVRSPSPWAMDSSEMKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWM1</accession>
    <name>A0ABM0JWM1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103242.1">
        <property type="nucleotide sequence ID" value="XM_005103185.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850263"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005103242.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13333" checksum="CD68E4642A6D542D" modified="2025-10-08" version="1">MAQKTEGIQQLLIAEKKATDRVHEARKRKAARLKTAKKEAEAEITAYKEHREKLYKNAEQAAAGKHGSAETEIAAYTNKQIVELEKNMKMQMQKSMVLVQDPLFDIDISLHENVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JX19</accession>
    <name>A0ABM0JX19_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein Rab-20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103568.1">
        <property type="nucleotide sequence ID" value="XM_005103511.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846667"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005103568.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24070" checksum="EEA90B74F44F892F" modified="2025-10-08" version="1">MSGKKKADLKVIILGDYAVGKTSLICRYIDGKFQTQEPTVGAAFFLKQWGPYNVAVWDTAGDERYSGLSHFYCRSAGAAILAFDLNNPKTFESLWARFGSILEAANEDCLKIVVGTKVDLLEPEHREITIEEGRKLSRDLNEHIDIRKLPHDPYFETSSLANENVQEVFEYIFQYCLPLSADQKKRHRNQQKSVVDLLENSEEGDKGKKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXK2</accession>
    <name>A0ABM0JXK2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenosine receptor A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101847056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005103902.1">
        <property type="nucleotide sequence ID" value="XM_005103845.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847056"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="64"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005103902.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40528" checksum="0202EF6616A37610" modified="2025-10-08" version="1">MSISHLLWGNNSTYSLNENMNLPITTQSPGVQYAQIVSDEQWYIFQVVNVVVISGLLSLFGVASNIINIVVFAKQGFQDSMNISLMGLAVADLCSLLTMIWISICMNPLFYNSELPFDSTDISYLTGSAPHVLFVKIATFITAFITFERCLCIAVPLKVKTIITPGRTKIIIISIYITITILIIPFFLGHRFEWVFDFTRNATILKSTYTAEREMLEVISFLTLGVFATTFSFVFVICCTIVLIVKLNSKTKWRLATAAKSDRAAGGVGVKDQKVVKMVTFIAVIFIVCAVPPTLLFFYMLIDPSFRFFGVYQNLYLVIWTSSFLTETVNSSVNIFVYLKMSSRYRAVFMKTFWNAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYQ4</accession>
    <name>A0ABM0JYQ4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100533552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="RefSeq" id="XP_005104677.1">
        <property type="nucleotide sequence ID" value="XM_005104620.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100533552"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048776">
        <property type="entry name" value="HAT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21183">
        <property type="entry name" value="HAT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Histone acetyltransferase type B catalytic subunit C-terminal" evidence="11">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005104677.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="47689" checksum="F3B8451FB4595665" modified="2025-10-08" version="1">MAELSVAKNELEEFKCSANDAIEFKLVRNVQDIDDEEKAFPPDMTHQVFGDSEMIFGYRGLKVSIYYTGSKLIPYLRISHSEVCNTKEHGVSPDDIEKLLAQELPPGYLTNLDTFKAALSDEATFKPFGEKIDSYTVTTKNGEERHFDVYFAKMEKSGFQKFHERIQSFIKFYIDAASYIDVDDPQWQYYFLFERYKEDGETRLAAAGYMTVYNFYAYPTHIRPRMSQVLVLTPFQRLGLGAKLVQTFYNTCYSRSDVLDITVEDPSDNFQRLRDFVDAQNCMKLKYFQLSELKKGFSHDMLHEAQTKLKLSKLQTRRMYEILRLKATDQSNKEEFREYRLDVKRRLNIPYMKTKRMFLKLENCLNPEEIAQTLGLVTKEQKFLTLENDFQTALAAYRRVLERLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZ33</accession>
    <name>A0ABM0JZ33_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ homolog subfamily C member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104922.1">
        <property type="nucleotide sequence ID" value="XM_005104865.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861833"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052763">
        <property type="entry name" value="DnaJ_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104922.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34260" checksum="664149472B15ED04" modified="2025-10-08" version="1">MFRFCRCHCLRGSPRTTFSDLQPSSSSAVAPGNTDLSSPSTPSYCSWNVPHSSMATSPNLAFYAVTKKSALNLFSVYKGAPFFHCPNPRRFITILSKANHYEVLGVEQNATGNDIRAAFLKQSKECHPDLNRKDPNNHKKFVQVNEAYSVLSKPLSRREYDLSLAMRTATDGVKSNSSGRDGNPYYHHPAHFYDEKLYSMRDKSKDEYYKSQPYYGVKGIEKISNMQIVTGCMIFMLCGIVLHFVAVKKSSDLHIKNLDARDVKTHELWMNAKKNAEMYTSKEQTEIWMQRAAEIRASKGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZC8</accession>
    <name>A0ABM0JZC8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Agrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101845945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105101.2">
        <property type="nucleotide sequence ID" value="XM_005105044.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845945"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047238653" evidence="4">
        <location>
            <begin position="26"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="152"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005105101.2"/>
        </source>
    </evidence>
    <sequence length="206" mass="22133" checksum="713CC1E650B192B0" modified="2025-10-08" version="1">MKMDYFFIKVVVAICFAILMKGTQSQTSTDTLCKNVVATLDCSLDTPRNICATNGVTYPSGCDFAKVHCQRPDVHIKYEGSCLESDAVGDSFCRDLLSYSCPVVSSPVCANDNKTYDNFCRYQQAKCSNKDLQLALLGVCPTPPPVTTTTISVFELICQGILNTPCPDNQPQVCGSDGVTYDSGCDLEKANCIAASGVTLDKTGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZD3</accession>
    <name>A0ABM0JZD3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101847676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101847676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105108.2">
        <property type="nucleotide sequence ID" value="XM_005105051.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847676"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF11">
        <property type="entry name" value="ALPHA-TYPE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005105108.2"/>
        </source>
    </evidence>
    <sequence length="652" mass="72189" checksum="C528BC44433E6922" modified="2025-10-08" version="1">MGQAESLSISGGDGHRYWVSINSKPMKRGGKKTIHKARLLGHGPRQGEKVVAKSFTDIEGTKEAWTHEVTKADVTKQLVTKFNEACPSAPRIRIVLPGIVEMDKVSKFENWREGRGGHRGLSKDEWISIEEYITGQMSRYCPWSTSRDVDDVAHSDDLQTFSHFTYMHSCESLVACDFQGVVRTKQSSRKTLYIVTDSIIHSRYKMYGVFDKGDYGITEFFKLHKCTDICKDWPRPTPLTPPPSFDDACAALLMNNITPPPQFENIVFPAYQGEEGATGGEGADGGLSRRRHRSAKEVRHRIRPQGSDQLEVEEPESLRRRSHSDADMSLASYLMHRHFHESVDDPNAAVMTPPPAYESVVVPPLQDVASPPTNNTVVPPVHRDTTQDVSSETAVAPEALSRKSSSTTSSMDELAKVTFALSLSDENSIDDSSVWQEDEFSGAATGHEHGHGNPKSGAQVSQTCMPPLLPLGAQRPSGSSGSSTRSYNNAQHQASGFAAQTATQHRVLAKSNSGGDHNRLYMARQATNRHRHASEEAALRGNPHSSSYSQGVRQHQSLRHVLSNEESSLNREVHRVHRSATDSSIQNSDGRPRSISDANAQLRRAASPLMQRRMNNERENSSEERRNCQELPTLIVPSAPPMEFCDVSFDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZR0</accession>
    <name>A0ABM0JZR0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multiple PDZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101862369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005105353.3">
        <property type="nucleotide sequence ID" value="XM_005105296.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862369"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015132">
        <property type="entry name" value="L27_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09045">
        <property type="entry name" value="L27_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="L27" evidence="10">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="143"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005105353.3"/>
        </source>
    </evidence>
    <sequence length="252" mass="27353" checksum="C15DB96A6C9569EE" modified="2025-10-08" version="1">MSGKMSLVNDSETAAEYVEVLQRKLWTRGDHSQDDELSSIIYMLDSPLFKQLLTLQESLQELKHVSQTQPLSEESFDITASGELILNDEAANGFTPEHVADSSTLKLRGEPFDPAVTDTLDYGQQSELDVAVEKVASGRPVHEVQLFKPESQSLGFSVVGVTKPDNEGQLGIYVQDIQPGGIAAQDGQLREGDQLVAINGQPLDISHHEAIRLLQGARGTVHLLVARPLPASDTIQAEEAVSTAATPRTTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZS7</accession>
    <name>A0ABM0JZS7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101848604</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101848604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105380.2">
        <property type="nucleotide sequence ID" value="XM_005105323.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848604"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005105380.2"/>
        </source>
    </evidence>
    <sequence length="205" mass="23374" checksum="8C1026242EB1F581" modified="2025-10-08" version="1">MERPEVSSVPVAERRVHGLVFDLSAYGIDLGELEVTAGFSLKLFGSTRQRFLSLALPRTELCLVRHMRLVLDRSMMRNIFVRCYNLCRCETEPELSDAWAIRHLQFSPRLYDIKLFQRLETVAYFQETDMFVLVEGEAARCCNFHTGMDVNLSVSGLAPLSSVLSRAACAVTEADILSLLLAHWKHSHNLARQFIRHGLKQDIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZT8</accession>
    <name>A0ABM0JZT8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDB1- and CUL4-associated factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105405.1">
        <property type="nucleotide sequence ID" value="XM_005105348.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854432"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23761">
        <property type="entry name" value="Beta-prop_DCAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105405.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="70240" checksum="9C0C3B5C919A928A" modified="2025-10-08" version="1">MPRTRRRRRDRPWQNPGQQAEADADTNVWNQGSQTSTRGRNHREWRPRQRTDYRAQGQRANEDADTNVWNQGSQASTRGRNLRERRPRQRSDYSTPVQNTRPSRQQAVASTSSESSRSASDENSTFTAARTVPHIASRPSSSSQGTSSGSRQTTARTESDIPGYYYDEESKNYYKILPDQMSGTSFLTRTKIREQNAEKQRQIDEKAFLENDSPECMFQFRNVIKSRARHLPGILQDVQCGQVPINDLKTYLLRKQCASLLPSVQEAVKAHGSNFVPGSLLEHTECMYPNSKFDTLLCMWTLKSYVPQYAQMMKVQSQVTHPHPDERNKPVQRLSLRVMGKPIHPMFHKISCLCWAPSRGNKCRAVIVTSCPFGKESSVATVVSLDEGPEPPHMPSNTDVHVSLGEKLVWTCAWNGWNQRVSIGTRGNAQVIDVVRRNKWVFNTCGGDPVTQEFSSKLPFELYSGTKKGLIIRHDLRANNRSEPVQKWNQTHSLACIKLQRDPNYFTASDITGRICSWDKRMNRVVLTYEGLFNEYHYRPFFFDETESILTSTGTDSYTNVWDVRTAVLLRRIPPPIQASNEGWPMAVFSSYWGGMPGKGCLIMAVRDRFEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0N2</accession>
    <name>A0ABM0K0N2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846835</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105978.1">
        <property type="nucleotide sequence ID" value="XM_005105921.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846835"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005105978.1"/>
        </source>
    </evidence>
    <sequence length="1264" mass="142217" checksum="1779DED55F5A43B7" modified="2025-10-08" version="1">MSKKKSYWQLMDLEVAQRNAQQDNQVHRHTVQQAFGEKIPVLISKPKSSTTPFGKMDKDGNMWPIDPKHQTGDANVSGGDLGPSSSTNGTRNGSDNLVRIDAVGESNAKKNGDEKSNKKPAPVERSREKRRSLSVPSEAGESRSGQSGSSIGSSASAAIDKNNRYGNFQTRRREPRRNSFSASRRRHGDGWPHGRYNNGRDVMDPWDQRRESTPRTPPPFNSFPTPQAFREWHGSTGRNMPLMDRPEWYPPHHASRRTHQLMHRPRERRNGVAEFDLGHRGDGFDPGWNPAYARHQNAFGYPNLGYEDYLRNPVVGSGWENPREYFGLDDPQNRNRYQNRSRQDRFQKTNSYRSSSIPELSLNRSAAVNCYQPGPAYDVCAEGNINGLTQQMNRITVFEPRSRPQSYDARLSKKLPNVFDQRLIKTASQPPSAPTPVRRRESDTGSKVRNHALETNRSAGNYSYGTRTDSNTNLIQRTPRNGHSHPNNIRVVSVPHPRNNLEKNTNHRENQEYNKTRNGCIQPKSRSRAHKAHLEYDTVFNHAPLVQTDQAPNETPSDRESSTRRAHRLNGLLSEVQEELVMAEILNLPFKRGPRVQNGTPNSSKLNPQASEFRPNSIQDGRLCQVPLEQNSTYDPETSRNVWPSTNKDRSDKNNNYIIPIESNESESVYDSCNSYEKQIENQTKPKVRDSSQISNVHVENTHQNSQFPVANGEFSHYQPVTVYNQNLAQANGQVVASAPVITAATQAGAVFMPSSTPAAHLIEPQTPQVNFQSSANFAQTPQVVDYQQMSVYNPPNCHAEFQTPAASHYVQAPMPQGFPQPGVIATPAYHEQSHFRFPENYQNHEQQGASQEMPPNAIFLNTPVIATPVGLYNGNHFTYQVASVPAQPVVNRPDLPLRTTQTEPRTFDSPHHQAFFQHAPVFNFQAYCMTVENDQPFRYPGTNVPTIEELKNPTKNKSCGEKKTSLMDRVGNTIKEVQASLKTSKTRRREGQESWEEILEKLIKLPPNFREPSDMAEYRQLRKLSEVISTYIKEIKKDSPGSLSESEIFQEVLDLSWPIASMNLDMVSGKMSNSLPEIVPDTDAAVKNGKSRTARMNRSRQCLQKAWNELAMTISRKCAIQIKRDGELTPIMQTQLPFEMSTRSEHSLSDELPQCDQVHPNASSTPSQGDGEHFTFGDGSLTTRPRPVSLAYSPAVSQDGHFLPQAHGVMLHSAMSGTVSEQNEHSDNRRDSLGGVNVGTRISYFESNAKGEEAAQRQTKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0V5</accession>
    <name>A0ABM0K0V5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101862296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_005106124.1">
        <property type="nucleotide sequence ID" value="XM_005106067.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862296"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="140"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005106124.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44650" checksum="0ADEA41E13E42E12" modified="2025-10-08" version="1">MPRMVKVHWRLSECPSRLTANIRDRLESWRIIYMSLCYNQFTTWNTVLDTSMEPLFWLVDNSARVMGPIMVTMVVLLTTMVVMVFYVCILPHIYYQTDIFWSLVHLIVAHWVLMNIVFNYCMAVFTKPGHPPQSVPEVVSICKKCISPKPPRAHHCTVCNACVLKMDHHCPWLNNCVGFHNHRYFFQFVCFMWFGTVYAGIAGYDVFKQHFFGNKDLIVPAFFFPINMVYHMWNKSQDEEAVNASSETNKMADDDSESDIKATLEDQVLHNAIILQFLLCAGVAIALGLLAAYHARLISQGQTSIEQHINNKERARLKKKNMKFRNPYDFGFWKNWKLFFGLSRGRSFFRHVLFPSRHDPVGNGITWDTCTFKLDHNRLLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K242</accession>
    <name>A0ABM0K242_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat and SOCS box-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850836</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106946.1">
        <property type="nucleotide sequence ID" value="XM_005106889.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850836"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051983">
        <property type="entry name" value="WSB_SOCS-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622:SF2">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005106946.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46112" checksum="6EBA2DAA4204ABD5" modified="2025-10-08" version="1">MRQVKSSSFEFLEPDQIDQADVSDHLTAALSPYNSGKSGREGWTCAWAPDSSYFAWSSGYRILHLIPWDANKKKRHDPADTEGLKERKYHMIDCGELIWALAFGSGLPQKASHIYRHCSYDKNLVVATGLASGRIKLFNCFTGSVIVELLDHRDTVRGLDFSKDGSLQLMSGSRDGTLKLWDLNNEGNMYCTHKARAKVNACKFSMNGKFAAAVGTNKTVLLWHGPIKDSPFYRLEGHHNEVVGVDFSSDSVLMATASFDTRVIIWNAYRVQRLRELGHLHPSPSLIFAGGANDNFVRSVNFSRDGVNVATVCDDGFVRFWHWEEDGDPVSVLQVSDPLCGQFSSDGTVLGVGTRSGDAQFVCAPQPLPSLLQLSRVAVRKAMRSDSVDGLPLPYLLKHFLKYRDFLKDDSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K304</accession>
    <name>A0ABM0K304_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Multiple epidermal growth factor-like domains protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101860924</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107573.1">
        <property type="nucleotide sequence ID" value="XM_005107516.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005107574.1">
        <property type="nucleotide sequence ID" value="XM_005107517.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860924"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021128" evidence="4">
        <location>
            <begin position="23"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005107574.1"/>
        </source>
    </evidence>
    <sequence length="763" mass="84411" checksum="4E545C8E46BB245F" modified="2025-10-08" version="1">MAEVFLTVATTLASLSIPASWSRECSQLERRVFFVKAGYVTSFWNAHERCTELGGNMAVFSGGSMKPKDRMSWMKNISDTFIIGGRAFGNNNILRWYADKHMSFTKALPWGHAEPKSTFDHKCIFVNKGIARTGKCHSWETNSVRALCQLSDSEKKYQNAKCTLCLCPGAESPSCKKDRCDLPCVELVEGQECVWYPCKQNEWNPPKCDKTCMCKDDCDSITGKCRGECIPGWYGDGDSKSCNRTKFDAGKFHHYETHNLTGCACRGDAWCTFSGLCVSCWPGAGGNYCAESDCPIRRYGRDCEKTCHCADPVKCAQEQGHCLQMPFKGCSGKWLGRSCTETICSTGLFGPDCQYICACKYGEQCDLDSGHCAAGCEDGWMGPSCNDTLCPVGKYGTKCRKDCVGCELGENCNHETGRCLSSYINKRSACEDLDKYGYNCDKNCTFKVVGLCTGCDRDFGDRCGECKYGYHLNADGLCQECPDNTFGIRCRGSCDVSCPKKGYGCNKFKFKCYEHCQRMVKTTCNNICSLPCPDGTFCDAGRTNSCQVCAKGRFGFNCARLCSHVCGPGVDCDVVNGLCAAAALPKRPFSIAEQCYPDLMDKTVSIWLPFWTVLPAICVVCPMVLFAIIFYFKSENTNIIDKYDLEEVEEEEEEEEEEEDEEDEEKGSRSDSSQSVNSSSSGASDGSRDDSSRDSDTDSESEMESDVENKKESGRKRRDKESGKRNNKESDNKEGTTENTSKIVNEGAKEAATKGATKKETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K331</accession>
    <name>A0ABM0K331_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SCO-spondin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101852722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107625.1">
        <property type="nucleotide sequence ID" value="XM_005107568.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852722"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="470"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="4">
        <location>
            <begin position="546"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005107625.1"/>
        </source>
    </evidence>
    <sequence length="649" mass="71408" checksum="FE76129A573F8475" modified="2025-10-08" version="1">MADLPLSDVIIQPAPASSTSKFVFSAPAGSSPVEVIVQVEKGGLLEYLLVEGTFTSYQVIIKDESLTASAPLENVDGDDTFVPGQENLFNKDLEDNEQIYIVFQGPAEGFDVSIEKFKLCLPEMRFCQLTKDEVLRELSFLPLNGVLGVSPDDNEEVNYGLTGPGDTLEEGTKVQGNCYVCECVNYVLECTVDPECEKCPNYTATCEGSCDNPELVFDFENPGVDPSCVANETCVPDGCTTPHNCPSPWGEWSECDQCVKQRTRTCDESCGSLCNNIQLSEVEQCEPCVTVPPPVQCDENEELKCYNTFVMCNESCKMRLDQDSCNSLIADEDLPCNESCACKDGFMRNQAGVCVEEQECECYNGTVALPMNYRENVSACKYCICAETGYECYTIDDCCELGEWSGWSECSVTCGQGIKTRTREQTGMGCDAEKLLETEDCMENECPCIYMGKEYAPDEIIDDECKYCKCDSGSMQCEPKNNPDTWQTDDCQETCYCGENGEMVCTNTSKPECEEIRNNCNNDTHMLEDNPDDPCCPKCVPRMKPCEDKVVGSTKLNYTSTNSGLCISEDIEIKVCEGSCGFSSSGGNYFASYSQDPIKPPAFDMNTYSDCKCCNANLVVKEVSFNCADESVTKISVTSIGSCSCMQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3F3</accession>
    <name>A0ABM0K3F3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pancreatic lipase-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101846528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107857.1">
        <property type="nucleotide sequence ID" value="XM_005107800.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846528"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046608015" evidence="5">
        <location>
            <begin position="22"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="41"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005107857.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="54187" checksum="1986DB0DA2CAE55D" modified="2025-10-08" version="1">MGKVIFIIFVQALVLQTAASASSSSISGSTHATTPKPYRTVCYPPLGCFSNRPPFHNAGGSVPASPESLNVGLRLYTRANRASYESLDYKTTNSRRFSNQRDTKIIVHGFANSGDTEWVVKMKDALLSEGDYNVIVVDWHSGAGFPFYEHATANIRVVAAEIKVLLEGYERKGLNLTTVHFIGHSLGAHLSGNAGSMLGSRIGRISGLDPAGPNFENTPDVVRLDKGDAQFVDALHTNGAYLSLISGGFGIHKSVGLVDFFVNGGQHQPGCRDSVIGKKRFLSSLGHQVSCSHGRVHEIYIESIKSRCSFLSYPCKSYEEFQKGNCLTCSNGGCSSAGYFANKHPSTGGKYLMTNDHAPFCGNHFDVYVKGHEDAPSRTDGTIYVALVGTQGETNYTRVTIKNRYLNGSIVTDNLVLFNKDVGEVQSIRVKYVKDPGFFAHGKNNHVISAVHLKSGINSKSYTTCVSRFELQTGVARTIPVRLVSRSRSANCEVPAYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4R9</accession>
    <name>A0ABM0K4R9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-like protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108729.1">
        <property type="nucleotide sequence ID" value="XM_005108672.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851609"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005108729.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="65044" checksum="F9D7DF7514C725CE" modified="2025-10-08" version="1">MDSAAHKSIHHQYLCRGLSKLKASSEHTDTVLVVGDTRFPCHRTVLAAMSPYFSAMFSSGMRESYDGIVTLKGINPSHFEKVLDFLYAGEIELSQECVIEVLQISSMYQIQALQLICEKFVSRDLSLHNCLLYWNLALIYNCSYLELHSFWCILEYFPQLKNTKEFLELSKDELIKYIDADGLNFEKEELVLDAVVLWLDHDVDRGKKTALDILPYLRFPFMDSTSVHNIAQHSSVLRNCKACQEFIEKALKANQNSPVPDVTIHPNAFKHRKEDALVMVDGRRQEVCCFTLYSKKLYFLAKFPYFSNSKAACVHRGELYVSGGYHQPNRMVKFLTEQNRWENCHDLLEPRFFHVMVSVNQYIYILGGYSKLGNVNPTGVERYDPVTDEICVVGEIAHSSGKMSAAACGDVIYMFGGSSYLYDYLDNELVSKSSVLISYNIKTNSSCLLGAVPAITMGSQAVSLDDTIYIFSPNGNVVTLSSDENPVIVHILRSVDHRHFRVVHHHGKFYLLPLAAPKFHEEVLVLTWDPRSCEEHMLLWDKLPRTLLDSHWMAVMIGKQHLCYQCHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5E9</accession>
    <name>A0ABM0K5E9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box only protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109159.1">
        <property type="nucleotide sequence ID" value="XM_005109102.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854445"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939:SF5">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST C-domain" evidence="2">
        <location>
            <begin position="208"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109159.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49499" checksum="596DE7CFC6E5C4ED" modified="2025-10-08" version="1">MSTHDCCWAALSNIIVLEKIFKNLNARELNGCSRVCKLWRDEAVKAKCSRRQMRWHSFFCEHNTADEEWWSSVNSYFLDCPIEPRAVMMFCTEFLWSCVMQPPKLKKKKRRKSVDLMDFYRFSLPKNCSVHITVTDGIIATDESMKTQEYEDRERVMSLVMFGDYAGVELVPFSCKHAECQVMQNHWAGSSSAVPAPLQKLKKKEVKMINLYCPVSGIDQEIGYSFFRMFDRPLIAGGYVNEKFVKDASGKFNSSSCDITMSGVAICGEDVQVASVLIRDEVETEPEVDAVIKQLTQYDFPLDSSLGLMYACVGRGTHVYNGAENVESKIFRKYFPNTPLLGFFGNGEIGCSYSPVDPLHMPWKRKSVVLSESGDGGGAEGEEDVEEDSVLSNAQLKRQMEEMRRKDIEYRLKHPPKLLHAYTTVMCLVSLPKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5S1</accession>
    <name>A0ABM0K5S1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101845884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an essential role in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109383.3">
        <property type="nucleotide sequence ID" value="XM_005109326.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845884"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF177">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044980475" description="Transmembrane 9 superfamily member" evidence="8">
        <location>
            <begin position="25"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005109383.3"/>
        </source>
    </evidence>
    <sequence length="592" mass="67326" checksum="17B14FBDF9E4D7E5" modified="2025-10-08" version="1">MATSWKLVALALGLCIMHRSLVSANTYKEGDKVLVYVNKVGPYFNPHETYHYYQLPVCRPQKIEHKSLTLGEVLDGDRMAESLYDIQFRADQPTKKELCKVTYSATDLELLRSAIEDLYYFEFVIDDIPIRGFIGHLEEGGFLPHSHKIYLWAHLHFNIEYNGDHIIYANVTTKEQLPISLDGASTPMELAFTYSVKWVSTDLKYENRGLRLRDNAFFPKNLEIHWLSIINSLVLVFLLIGFVVIIMTRVLKSDFARYNIEDEEDADDLDSDDNGWKIIRTDVFRYPPNKNLFCAILGVGSQFLALATGILLMAMAGMFNVHRHGAINAAAVVLYAFTSSISGYVAANMFKKMGGDGWVWNINLTSALFAAPFFMVWAVINSVAWGYGTTRALPWTTVVLLMALWVFVGYPLTVLGGIFGKNYAGSFDAPCRTKNISREIPSVPWYRSAVAHCAIGGFLPFSAISVELYYIFATLWGREQYTLFGILFVVYGILLSVTACISIALTYFQLSAEDYRWWWRSIFSAGSTGVFVFLYALFYYYKRSNMSGLLQTLEFLGYTALTCYVFFLMLATVSFFASLKFVRYIYVNIKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K773</accession>
    <name>A0ABM0K773_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TELO2-interacting protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110363.2">
        <property type="nucleotide sequence ID" value="XM_005110306.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856385"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24176">
        <property type="entry name" value="TPR_TTI1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="37"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="807"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005110363.2"/>
        </source>
    </evidence>
    <sequence length="1153" mass="128616" checksum="2EC411DA8ECDF197" modified="2025-10-08" version="1">MAGPSSEQTGSESKPKNAVMEADDHLTAERSAGLALMKPLCIGLMQERTTGSVQAILNALPRLDDDVAREIQVYILFPVKTALSMKDLSDNMFLALCQVIEALYRKTKMAEAHEVYDIIGLILLRVAPPKLSSQIPKMSEDSKKAMCDAVNSVLSAMPKKAFEKFYILKNVPAIGQLISVLLQIAEFERSKASQFAALSCMKTLYFYESVQYGPTNEIDDFTCLKSLTFCLPAVTMAAARIITGDSKQGHKVFVEAAHLWTIAVYRAIDNRVYQNAVDKSASLQKQKKEKKGDPLDSLTVVADTAWVETTAEKLKVLLEKICTARSHSHHKARMALVSLGSCVLIHCNSSLSGLVPLAVDLLVGYLADPRPEVSQRASEVLRTFAADANQSGHKRFLVETLQENLYNLCTSLPRQMRMADEEEKPAIIRLLRGYLTLLGTDVRTVLLSQAHLKRVCLALVNSLELDTSDIQILEERNTLLHQDQDVFVEKSSSPVKVWKRRKYFKHVIDPEVISELLRVCQLLGKFGDLAILVDFFLELYHESSTYQPAAILIINEMIVGVTEAAAAENVIDSSDELIPNLPALNDLITLLLDEYLSTENLALVSRYDDTKSAASSPSSSLSSSSSSQWMSSSLSLLPSSSSSTSSSSLLMIESPESFESKKRLSQRNRAIMLACLFMEGVGNFAMALGSMFESHMVRALYPLVENLGHENVHLSSTAYFALTHICTACGYNSLDLLMQENADYLVSSVSLRLRHITVNRRCPQTLSVMMRYCSSSLLPIVEHSILQLLDTLDDHYAEELLLFLPALLELATAIGRWFPSPTEVKEEAQVPEALTAELDPQSIVAFVEEYVRTKKTADMEEDGNEMSDGDGTTEERKMEDIEADMQKLMEEQRKEEERQEAAAEAEEEQEREKEKTEECPRHLQVVIDILQRVKHFLTSPDGRLRIKSLDILCQCVTDLKGNSKELLPQIHQLWASFYPLFRSEEKFVVIKALTVLHLISDLGGDFVRQKTMKNVIPGLSSFMDKQGKISSGSKSAYQITGNYKLQLAALHSLGPIAKNLCLDSGDLESVAKMCLPYLCDKQPRPLQQASIESFSFFIGLDPDAMWFLLSQVHFPPMPEPPGPEFEPIKVPHTSDQKNSFKTNVQHLFDTFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7Q5</accession>
    <name>A0ABM0K7Q5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Prenylcysteine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101854760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110758.1">
        <property type="nucleotide sequence ID" value="XM_005110701.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854760"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046096602" evidence="8">
        <location>
            <begin position="34"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="136"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005110758.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57302" checksum="9FC2FBF224989844" modified="2025-10-08" version="1">MAASWFSGQYVLSVVVLFLLLSSFPSSFDKVSCTEEDEMLPRIGIIGAGLSGTSSAYFLRQLFGKKATIDIFEAGKVGGRAAVININGLNYEAGASVIHKNNHYLVEFSQAFRKNTVRLSHSPGMVGLYGTDDILFQTSDWLAITLAKLVWRYGTDFYNIQSWTKNHIFPKFDRIYKFQDQGLSFTTVEDLLGAMGEDMLNMTKHSIKDVLLDAGLSQRFVDEFGMAAMRNNYGQTTDVHGFVGAVSMAGVEPGLWSVEGGNQRIAENLLWGSKATLVEAKVSTVALIKDELGTGSVSYEVEYEQSGKTNSREYDILILAMPLEGTKNEINFVDFPVKVTPFSQPFHKIVTMFVQGRINKTTFGLNSADDFPPDLFTINRDTFFNSIGKQSPVDSHQKPEKSPPSDYAVWKTFLNQVPSEEQVGKLFDKYEDLRFVDWMAYPEYKPNMDLPPFMLYDRLYYVNAIESAAAAMEMNVIGSKNVALLAFNQWQGNFDKIDELHLPSVSNDKSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8B3</accession>
    <name>A0ABM0K8B3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101856851</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111170.2">
        <property type="nucleotide sequence ID" value="XM_005111113.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856851"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF15">
        <property type="entry name" value="SLL1173 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="136"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111170.2"/>
        </source>
    </evidence>
    <sequence length="284" mass="31393" checksum="7385B0BEF31B60D9" modified="2025-10-08" version="1">MIDFRRGRERAVLVVGIAVVCVTGLTIHYLYQPVPQPLRMNTQPVLAPQSMIRAGGSSNLHPSVNVVKSYPNGELPYKDCVPLPESPKTGVKMCVYPSQNDVYVSKDLKEGRLYESHLVHQMAEVLKSDPTLQFIDMGANIGVYTMFAAACGKTVLSVEMLPANIHQIQHSLAESGLSNQVTLVNNALFSDHRSLTANFISGNVGATHLNVSKTDFAKYGMQEDNSHTVTVKTICIDDLIPLLKSRKVLIKIDIERTEAKALSCAHKFFDEVDVRAIQMEWLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8S6</accession>
    <name>A0ABM0K8S6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101864269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111531.2">
        <property type="nucleotide sequence ID" value="XM_005111474.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829115.1">
        <property type="nucleotide sequence ID" value="XM_035973222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864269"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="110"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005111531.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035829115.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="27753" checksum="17872D847DC218BE" modified="2025-10-08" version="1">MSGFDQQEGFFQTNYYDNQQNYSYDNQGQQAQFGQEPQFGQFDYSQGYSGEQQYAAPEQNMYTGSIMTPSTSNFADKADSGGDSYEDEPPLMEELGINFDHIVQKTMAVLNPLKNTDHSIMQDTDLAGPLVFGLAFGGTLLLSGKIHFGYIYGIGLVGCLAMYCLLNLMSLSGVSAGVTVSVLGYCLLPMVILSFASALLSLQGLVGLVLTLVTVFWCSTSASKLFVSALALDSQQLLVAYPCCLVYGVFALLTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9B3</accession>
    <name>A0ABM0K9B3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111948.1">
        <property type="nucleotide sequence ID" value="XM_005111891.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847234"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111948.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="70308" checksum="CA41966A250CC12C" modified="2025-10-08" version="1">MSGAAGGTTVDHADSSHQVLALDSLGNSHKVLQSREYDTAGWTFEQEKWPLLNLTILPILAVLIFLVCVALKMYKWYRDGSKLKARGDVEFGDESEVNYGIITAGDKHFCQIDIRSDTTSVYDTVNSFRYMGNGAAIQPGPHPYQDTVTSYKSLLLQRADGSQYDSVKSYKAFLQRVTQNKDLAVEVKLLENYPIRSKSAEHCFVVEEESSERSGDVATKLLNFLPLKKQLHTEGKISELERKKQRCRRASTDLPPAMRKRSASNPTCRRAVARGAASLPSVHYAVSSDSDEETQQSFQSDRRRKWAERKKMYRSTSAGKISKDISHMVCADDVVGVGKRRRHFSADSARRPGKTWYVHKKGTTAMAKKARETPPNDHQVGGRPECKVKVTTDRRGEESSSENPHSSPSSCEVEAMSDAVVSDSEEDTRLNTILSTASDKTLDNDVFFSLDSGAELGSSTELLQHSPLRLSQVSPAAIPPCIDEEQDLRNLDELGPVGSSPETLPIPRLLYHPSSSSNQNCRNVVSSKQVFVENNHQAIPTISSDFCHSNSTVGDASKKPHDDPVSTHPQSSSTLAADCHKPSDVHNKGADLSKDGLEKAAAAAAGGGKAGVSATGKVQSPQRVQRFHVTFVNADSSTLQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA96</accession>
    <name>A0ABM0KA96_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable glutathione S-transferase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112690.2">
        <property type="nucleotide sequence ID" value="XM_005112633.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863952"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005112690.2"/>
        </source>
    </evidence>
    <sequence length="97" mass="11024" checksum="B017298C7EB2F34E" modified="2025-10-08" version="1">MVSYRLLYFDQTGRGEILRFLFALGGQKYEDVIISQESWPKFKQTVPFGVLPVLEIDGKRYSQSVALAVYLAKQFGYNGKTDLESLAVLEVVQLVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBH3</accession>
    <name>A0ABM0KBH3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger BED domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101858917</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113571.2">
        <property type="nucleotide sequence ID" value="XM_005113514.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858917"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1070">
        <property type="entry name" value="Zinc finger, BED domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005113571.2"/>
        </source>
    </evidence>
    <sequence length="564" mass="64185" checksum="5AF289E78AAB0162" modified="2025-10-08" version="1">MATCRKNASDIWNFMTRTSPTTVACNLCQCIFNHTTGSTSNLRRHLQVKHLSMTGPKPLEKNDESVMKETPRRPGSMTQPTLLTTISNVSKYGADSIKKKALDDLLLEMITRDLQPFSIVEDRGFRGFVRGLDPRYELPSRRTLSRDLLPRKFQAEEQKLKASLESVTHVAITTDLWTSRQTESYITVTAHYFLPLPSWDLQSAVLTTQRVTVDHTAANIAKVLTDIFHHWGIEDKISSIVTDNASTMVSLVKDHLKKHHVRCFAHSLNLIVRDALKNSGELVELITKVKSVVSFFHHSVKATEKLLSFQQNLGRQQRKLIQDVDTRWNSTLHMLRRYEEEHTAVTGALCALSKTTMSLTDAEVDRIRAAIEVLTPFELATKEASTEKHTSLSKMLPTVRQIQEKLSGESSSALRDQLQAELRRRFGSLEDNFTLGAATLLDPRFRRLPFCDQSSAKNVEDRLVSMMQRSEPQQTSATEASQEVNNDGPPAQKKSLWDTYMKKVEQLKKTASPGLTGPYVEMRRYHESEFLSMMEDPVQWWRENCSNFPRLSTLARQFLHIPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBJ7</accession>
    <name>A0ABM0KBJ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Forkhead box protein P2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113607.2">
        <property type="nucleotide sequence ID" value="XM_005113550.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849433"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113607.2"/>
        </source>
    </evidence>
    <sequence length="129" mass="14197" checksum="2E2235F07336DADA" modified="2025-10-08" version="1">MMAAQQGLSQQQLQQLQQQGLASPLQQMMQQQSMVMQQAQQQKLHEQLLHSLNEQLQMNLMHQAQLLKEPGGAGKGGGAKGGGASPSTNQNLQALLLQHQQIMQQIQLVQRQFALASALQPFGMPQGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUD9</accession>
    <name>A0ABM0ZUD9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="3">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101863796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012934667.1">
        <property type="nucleotide sequence ID" value="XM_013079213.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863796"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01780">
        <property type="entry name" value="RA2_PLC-epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17114">
        <property type="entry name" value="RA_PLC-epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028398">
        <property type="entry name" value="PLC-epsilon1_RA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF6">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="7">
        <location>
            <begin position="2105"/>
            <end position="2271"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="2273"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="9">
        <location>
            <begin position="2467"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="9">
        <location>
            <begin position="2603"/>
            <end position="2701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1241"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1543"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1984"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2651"/>
            <end position="2679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2766"/>
            <end position="2790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1545"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1558"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1588"/>
            <end position="1597"/>
        </location>
    </feature>
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            <begin position="1984"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2001"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2017"/>
            <end position="2061"/>
        </location>
    </feature>
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        <location>
            <begin position="2651"/>
            <end position="2663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012934667.1"/>
        </source>
    </evidence>
    <sequence length="2803" mass="314798" checksum="C761BD175FA1A453" modified="2025-10-08" version="1">MEEKDRDTQTPFIRLSGSANSLTGHYDGDLSSCPHSRPTFSPLNSPSCSTEKLESSAYHQSLREYFLTGLPMVVHPVIVLRLLFHRLFGNMIRRKTLYSDAKLKPPKVDKVDICPPRKPELSQGDGVTLAKEQQHSHQQQQQQQQQQQQQQQQQQQQNKRFGPEEGVGLQDQEQQPLLQQQQQQGKTPKPKPSLRVMISDSGIDEDEGHTHDPDDRDVMMTGTGSEKILSPKSQATGQNYLQSKNGTTTKLALRAIGESLVTPLDLDIMSKNGESSGRQIGGSATTPPEVEASGAQELPMKSQKKLFRWPSKKRLSKSQVNVQLTHQDSIVSQHSTASSNDSSTPEVDIVAFQRELINLPTFVMETPPCEVSPVFSRSSSVPENLASRHRSNLINSSTGQLHVHTDIADSKHSPSRPTFIFPGTSLSVGTFKTGSMVTITTTDVGGKSERILHQPSTSSSAVPVIPSLSDHSHHHHHRPPGRITSPKGTPPATTITVHFEAPSSPNPSTSSQSPQATQFDFPTIPPSTSFSNHLSVKQEYGPPSMLSPLQQQFMPHTSLSSPALCSPTNDHRASGSPSCVSSTSPSATPSYEISFQHRGVLKVLESWSAICKTDLEGNSLMALETMEFLKRLSTMGHEYKVWCQKFGNSLRLEECIAADKAAEAKDDNASIHMQYKKLQQLIVSGDLPCSKEEAATLAGIQVHLEEAWPETDDDDETVRHAQARGNHHNHPHHQGSNSCGSPGDNVSNPEDSPQEQTRCFRVYGDSERQDNLRHKKELIRSHRAQRITSTRRSTKFARTLLCTGDNNDWQTQECLDLTRYLPPHYTSSKKVRELIEDKHTKLWHTPHYENEAKLKQLYIKICKNLPSYGCKLFQVKEILRGNTQKKVPRLLAISNEKIMLLDTKTQVPAKWHQLKDMEDWLSGSGKAHDNLVLEFRGTKPWTLAMPTVDTLKSVTAAIWEALDMDGRFLGNGAMQRESFEFDYQRRQLTPRPELEPLSKYTEELEGLQKLLHFPEEVALMLTETEHQLFCSVPSQHYVRHVTMELSRPLLQKTQPSVEQLIQRFNEVSSWVTQLIVTQATHDDRKAVLSCILRLTVYCWVLGNFNSAVEILCGLRSEKLKPFWLSIEDEDLSTLYSLSDMLLTRELSPEYREAINRALDIPQCKVVPFFGCFLRELKSIFVGVPSIVVLPSEENQSLEFVSDFNGEDRFMTRIGVGGLINLDKLRQAHLVLGDIRLFQQHGKKEEEAGEEDEAASAASKDTQSTTYDSDIDYDLDLDSYQPVRPLSSEHEVMVITPRVLQLDLQTLQILNHGTTMIQWDEDAGRSGLCVLRLEADNATLTWCRPGWSALRGVTSPPDFILHSDQPHPSLHVLCARYSSGSEDNYNSLEEGYLDVLHIKEVYLGDETLDRASISKRHGLESLESDHNCITIVHGSSLSANHKLWFVGPPSVTRAWYRGLCKLRAAAGMLRNQMDKRVMWLKQQYLQLYYDGEKCQGPTPAEAVKVFGGRSWSSGLPSSALSEPVGSFKRAPSFVVGPPNIFKKGKSSGSVSKQSEASKGANQTQTAAPVDSGKSTAGKSKRTPSPLRKVRSEMNKSHNSDPTLNQIARGSPTLGFRPRSLTFSFTSRYRSRRRRMSLGCRTGDKSASITHSTQLSFLDFVDLFKSFGLRCRKDLKDLFDQMSSTKKPHVDEATCSVDIPSQVPTSDSICSVTRITPQDLKLESQQRHKICDALAVSSIISNCAGVDTSHSSYLTPAEIHDFLVNFQEEHLDQEEIAELVRRFEPDPAMRGQCFMSFEGFARMLMDKENYAHIYEKSHHTDEDMDHPLPHYYVASSHNTYLTGHQLKGESSIELYSQVLLMGCRCVELDCWDGEDGSPIIYHGHTLTTKISFKGVVEAINRSAFVTSPYPIILSIENHCSLAQQQKMAQIFVNVFGDKLVTDFLFDSDYAEDPQLPSPNQLKHKILIKNKKLKDNDSLAAAKKVYTQNRASSIPSSETASINDFDDDDDEDEDEDDVADVVKELRRSVDSQDSPTPEHEDKNKEQSRSRTDSLEELRTSRDSDTFTSKTTRPKSHPELDWQFDEEMTSNKVPRKTKPKKASQIAKELSDLVVYTHAVKFRGLSMSPNTSLKQKKLPARRSILTSSMGTSPSTPVLLPGSAEKAEATLQVTMPRLKRCEVPSCYLVSSLNENKAKQLCRRSPLATINHTERQLMRTYPAGMRIDSSNFNPVIFWAFGIQMVALNYQTEDVAMSLNTAMFEQNSRSGYVLKPTVMWDKSHVMYNRFNPWDKEFDGLHTTILTLQVISGQYVCQNYSTNVQVEVEVIGIPVDCAKQKTKVVPKNALNPIWNDIFTFQILFADLAFIRFVVIDASTSHMVTQRVIPLKCLRPGYRHVRLRNGSGQPQELSTLFVYTKHEEELLETRNGLDISSLTVSSVKRMSIFSKVRELSEASKQDSKEILTSSGTKLKRRMFFISVFGVTAPDEYIILKVTQDSTVADTIAQALTKVGRLDEKVADYVLVEDVQSGWEKKDQEKASCQRILDVGEKVLAAQNKWKGAGKFILRRLSDDPSSRAWMTTMLKEQKRQMEESNTDWEVTEHMFLVCVFNVSPDQPYTIFKAPVTSTAQDIITQAMKKAHRANTEDPRDFVLLEELASQSETHQATSSKRTGSEKGDSSRTLADDENVYQAQNEWKTAGRFVLMSRMEVSIDEEEKKRYLKGSISKGGNFTKRFGSKRLSRHPTQGDKLLSCQPQETFHRSISFPSQVNNSAVVAKATAPSPTMSPKPPERSPALPFSKKISKLSFKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUN4</accession>
    <name>A0ABM0ZUN4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101846195</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012934814.1">
        <property type="nucleotide sequence ID" value="XM_013079360.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846195"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055162">
        <property type="entry name" value="RET_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF617">
        <property type="entry name" value="RET ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22540">
        <property type="entry name" value="RET_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="220"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="772"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1081"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1131"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="806"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012934814.1"/>
        </source>
    </evidence>
    <sequence length="1194" mass="133559" checksum="88D3BB3FA2A4F36C" modified="2025-10-08" version="1">MSCSAYRPGMTSSMTSRSVMLLLISALAHISIGGIYIPRRQYNFFIPPVADTPDLTIKIPVLENSAVQCEPRQANFLTTLSDFVDTAYENNAIVLRFIGNVNASISDEPVTFDVTITCDADTESKSHNYYRQFLTTSVTIVIQATPTELPPDFHRDTVSGQLFNANVTKQLCFGGDLLAYNVTENDKNVRLDVISGYRKLIMPEGLEATLIPKQDNTVGLSVDSTSQEVTLIRALDREEQETHTVPVLCKLTYKGSVLFNKSYDATIHVIDVDDNVPMAMQGRKILVPLDVRLLNNNPKSSQLTLLSYDPDSLALADTSTFAVTLNDSATPFTLKASNFFKIPKWKQERDKKKPSATIIRTVLLLKPVNPSFLPYVVDVTIEDLTYTPSLTATPKKNMAIHRLVVQSQTSDEVIRRDLPTIRMDVAATRYSLVVRLEEEPEKVPTNVSYRIVTSNPEALKRVLAVTNSGDVYVNEVYNLTRYKGINPILAVVTKTDSGQEVERIAIRVELADTLREGPGDECRAGCSAEYNEEDCVTSCGYGAISGRCSWREGDTTMSANYSTCTPNLDTCPDGICSELEVKDFLICPQDCSQESMTGQLLRWPLNRGIFKAKGPCWCDGDRYCQCGPLKLPPGHTNYSFSGTAGHREKSGQHDPLGADPNPGDDEPACSSSCRAAIASSVTVVVLLVLLVVVLRWTAWRRQRRRQSMSLKHVNSLVSMAAVPSDYIVDDSREQRAHAHRQTSSASSLQWPPKVAFGQDVFEDKWEFPRHCLTLEHVLGEGEFGQVVRAQAHMLRPQEESSVVAVKMLKPEASGAEYQDLVSEFQLLKEVDHPNVIKLLGVCTLKGPLYVIVEFCELGSLRSFLRASKFKNKGSWEDKQRSGNDPSMISEKNETRILTFRDLFSFAWQISKGMDYLSGLKIVHRDLAARNVLVTEGMKMKISDFGLSRDVYEADTYLKMSKGRIPVKWMAPESLYAQIYTTKSDIWSYGVVLWEVVTLGASPYPGIPPERLFPLLSTGYRMDRPDDCPEELYAIMQKCWKTEPEHRPSFFMLTDILDSLLQQNTEYLELADEHYFTHNAASDRGDRVSRHPTPSFPDDRHYGNLCPVTSLPATQPDAYVRPEWSADESDDESRLPESSKLLTDPHADTQKTKQADTDKFKGADDASVDTSLLNDCNTDTTHKHRVLVHENLTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUY5</accession>
    <name>A0ABM0ZUY5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MAP kinase-interacting serine/threonine-protein kinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101855912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934977.1">
        <property type="nucleotide sequence ID" value="XM_013079523.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855912"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="123"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012934977.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="46245" checksum="7D1F41BC1170F8EF" modified="2025-10-08" version="1">MRTSVYTQTVKETGLSKASEPALHNCSSDDDVLNTLKSDGSYNNMDIVLRSHVSAMCSEDGVLCTPSIRKTCSDSTLLSSRANTDYECEASGTFPYCSNACEVEQNPKLVKQPSTVNFHDVYEATEQKLGEGSYGSVFTYKNRESGAECAVKIIEDCDDASRRRVLREVGFCQRYSECDNIIKLVDVFENGDTFFLIFDKIAGGELTRILASRECLSETEASRVTGAIARALLALHNDGVAHRDVKPENILCHIEGEVTPLVLCDLGLASHLPSPNDPLTEGDSTKPAVVVSGGGSPDYIAPEIISVMCGQSTTPYDTHCDLWSLGVLLYEMLFGVMPFSHGCEQHTGSIELECEDCEVVLYKDILQGNYHFPKDVVELCSDSAVDLIQRLLVVDPQARYSAAQVLQHPFVAAYASDVLVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV00</accession>
    <name>A0ABM0ZV00_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TATA element modulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935003.1">
        <property type="nucleotide sequence ID" value="XM_013079549.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852905"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="1284"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1210"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="751"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="894"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1210"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012935003.1"/>
        </source>
    </evidence>
    <sequence length="1392" mass="152991" checksum="BD055EA696F8B8CA" modified="2025-10-08" version="1">MSWWDTAGITNLASQALKNAQKKIDKVLDIDEKTSGSKRKRGTSQQKGTDQKSEKTPEKTGSKKDKDAPEDQGADFWSGWMGSGGRKESKPEDGEKSSDSHSSWNLPWSFAATGSEDQDSPVKSELSVDSNDKQVAPSDRKATASESASERAKSDIAVTDDTSEVSELDEVTGQDVIDSKAASNSPTEAGIASGISSSGSLPDCKAEDSSSGWQDFSLDDNIDELIAGSEGEEKKERLAAVSEFQGSGVVSSSSPTEKESQILFVKNATSPAAKQEDSIASAIPHLDLSPPQAASTSSGFEDKARETNTAVTGETTVLPLQLDSSGLKTSTSSSFTEVCEDSLSELSLSLLTQDVDELPTTLPGEEHGVSETRSEPLVVGSTVDVTLEVNDTVLSGEAKGVLQADDSPLSQVQNVDSVVEDTSGEQPVNVSPLGGAVPGQERSQTEVSGEYVNISSVSSDGAQTLLSETGSDDVVQASSDLDLGDSRASSDLDLPGGQAGSTGSSDTSKFDSSMDTVVDRSLVDTPSEADHDTTGQGDEPYSLFGEKEEGFEKEEREKLAGSEGTPASLSSSYVKCMIEEAMEESKTEDSGSDNHSSGEKSESSKVDSEFEKSVYSGHESSDDIETTTSSDIEILQAPSANDESKFHTSFDLSPLKIALQKTAGAHGHRRSDSQSSSSAHSKSGELDHPSPERGESSLWRDDDSPHHDLQAVREEGVDNPYHPERLLKLCQRTLLQELSGGQKLAEMAEVLQARENKLIQLSKDNHQLMEDNSILRNQLQQSEEARETETADLTAVTNEFTARLSESEKKIQQVLKEKENVKQQLGKTEEELKKRSANVDLEAELEEKTEQVEQLMAEGEKLSRQQLQSNNIIKKLRAKEKETETTITGQKKKLETQTAELERLTVVLDSKEEMEKTQGEAINQLNAAVQKQEKELSKLRSELEDSQEKCRGLQAALDNSYKEIAELHRSNASQDSKAQEAALSAESHVREELKAAMEREQQRFRQEREAFIMQADDLRLDMTRLEKEHSRREELLRQEITHLQERLQEGESRSQELSQTVSSATRPLLRQIENLQATYGAQATAWEKVEKNLTDRLAEAQTAVAMAQEKERTGSERVMELSARVTSLEASNSRLKQEKAQLVAQGEADRGRLEELEDNRHSVVAQLETSRQRMVEELNQLKVDKVHLESQLGVERTRLETEMKKGLALEEQLRLAERERPRSRGTPSPSPSMSVSRQESLVGSMHERQSPGWSWSFHEDAEAGGSAGTLGKSSVYDSLRHSGAAVVVENMQAQLKQKEGEITQLQSEIQQLERTRESMARELVDLSNQNEELKEKKAEHEKLQTEFQELSGRYSALLQMYGEKEEQVQELRLDLQDVKEMYKTQIDTLLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVA1</accession>
    <name>A0ABM0ZVA1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein PHOS34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935194.1">
        <property type="nucleotide sequence ID" value="XM_013079740.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850872"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935194.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17727" checksum="914C0AD1D7174D44" modified="2025-10-08" version="1">MAMEYNRVVLLAADLSEHAEKAFNWYVQNFHKPENKVVIVHTPEYSMGPSEMSTSKIEEAIQEANAKTEMIKAKFVNKMSECGMNGEFVALEDRSPGHAICKYAERINATFIVTGTRGLGKFRRTMLGSVSDYILHHAHVPVLVCRLKYLLKDDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVI6</accession>
    <name>A0ABM0ZVI6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor ionotropic, kainate 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101859917</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935403.2">
        <property type="nucleotide sequence ID" value="XM_013079949.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859917"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="13">
        <location>
            <begin position="156"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="166"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012935403.2"/>
        </source>
    </evidence>
    <sequence length="571" mass="62912" checksum="BE5AB7D1620E520E" modified="2025-10-08" version="1">MILKTINAFNYQRKFYEVAATLVEHVNVSLDEETQEAFQSPVPRYVSTCDEAGTVDQTEAHAMERPLRKILSELFPGTVHDASAANPDVFLLQKLVTVTHALAESTPLPGNERGLMTSSRVHPLLEEVGTWSVDKGLRLGNRRLYVPKTPLNVSGTLLVGTVEAPPFTIKSNGSWSGFSVDLMIEVLEKLGLKYQIIESFDGKFGGKSPNGSWNGLVRMAQLKSIDLAIGPISVTSERAAVVDFVQPIMEDGGGIIVKKVEDTVDKLFSNMKPFQATVWLTIYAMIVLMAALFVLVNRFSPFRWPASGFGNSVKHCVHRKRDSAWVFVSSYMEQGANRLPYNTSGRMILGCWWVFAILISASFTAELAATLTVNRARQPIETLADLAEQTDIKPIAKQGTTWYSVIERAETEIFQKLRVLARSAPKVTSTRQGLDLVRRGGYALITDYSQIKGQRRMDCENLVIAAGAKGRGTSLHPIFRSIIQLHGAGIVDKYKRKWWPLATQCPITNQQVTAKSQGLDSAGAQFIILAIIMVVAAVVSCLERLVASRCSANTTNDILDALNRALEIPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX39</accession>
    <name>A0ABM0ZX39_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">5-hydroxytryptamine receptor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101849365</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936315.1">
        <property type="nucleotide sequence ID" value="XM_013080861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849365"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="41"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012936315.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37058" checksum="396EA95814C66696" modified="2025-10-08" version="1">MSTVPEATTQSSVSSESLEVTLVDIGLCVFSALLSIFVIGSNVITILAIWKTAALRSITNAYVASLAVTDMIVGFDLILMALFMLPNLRAELFYKSIHACVLMQGISIAMTVLSVIHMTFIAVERYMYICKPYLYPRVVTKRFVSCTLAFAWTFGIFYAILPQFTHVPYGEIPLCDITKTLRIEYLFYCISAMYFPVVCIIVAMYVLILRVALRQTKAISSTVPSVTGAISQQGNTGTGDQHKNSKDNASRRATLKSVKFFLTVFGVFFVCVTPTVVVAGLDFYTMVPPSLYRLFNVITFMNSGMNFIIYAVQNQQFRAAFLRLAPWSKARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXH6</accession>
    <name>A0ABM0ZXH6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium bicarbonate transporter-like protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101848427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936531.1">
        <property type="nucleotide sequence ID" value="XM_013081077.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848427"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="10">
        <location>
            <begin position="168"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="10">
        <location>
            <begin position="357"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012936531.1"/>
        </source>
    </evidence>
    <sequence length="678" mass="75838" checksum="922A0B7BCC3E3045" modified="2025-10-08" version="1">MDQEFTVDLAVAQIFTHHIGTNPQRALQGTNFSDEYGIMFDDMWLCLLCEISSVRKRHIGLARLESSMYLIPSCQEARFLIIIISNPAEKGTRSGLEAGRYFATLMCSPDFRQRMIKANTVDLMRELLIEESMMLERAHKFEAEKELEMFDTIKGGPGFSLKELFYPPFAGIRADLARRIPHYLSDYSDGVLGFKTLQKLFAAVLCLYFACILPLIALGYLLSTSTKGRIGPKSLVFAQSVSSIIYGIFGGHAVVIVMISTPLVLYAKIIHSVASDLDLEFPALYSLTCMFASTLLILYSIFNLANIMNYFTKSIGETLDVFVAVTFAADVIMALIANFQAHYFSEACVKPDLKLEDTCRRDTSMLYVLIVCCTLVMGLLFNSFTMRPFFSASIREAISDYALPLAVLFSTVIGSFFFSAVFQEPFMYDSDEVILIIPDLKGVPAKAYVMALLLSIPLSLLIFTDHSTNAVAVNSPVYKLRKGSAYHLDLLVIGFLNLLLALFMLPLANGASPHSPLHLKAMADIDNRIEQGASVQRLIRVRETRLTGILMGCFIGMSLFLLPLPLNYIPKAVLEGMLIFLAIVSLNGNDFIERLTLLFKDQATFPANSTIRQLPLSILTKFSALQLVQLALITFLSYSPFVYTQMLFPIMIILLFPIRHMVIVKFFRKKQLAELDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY35</accession>
    <name>A0ABM0ZY35_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="RefSeq" id="XP_012936878.1">
        <property type="nucleotide sequence ID" value="XM_013081424.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850163"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF547">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044949216" description="Peptidyl-prolyl cis-trans isomerase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="47"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012936878.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25574" checksum="7B5C1618C4C1E780" modified="2025-10-08" version="1">MKSVCLSAAVLVAICACAFADKKEEVQWQSKKTNVTVTAEATIDILVKNYDSSGDLHGTLRVALFGEDVPMTVLNFFSICNGVKRPSGELKYSNTYCHRLIKDLNFQCGDVTVGDGSGGISMYGDTFNDENFELGLSERGTFAMANKGPNSNGSQFFVTFRSWQYLDGFHVVFGQVIGKESLEFLEKIGEIDVEDDGLTPKRKIKIVDCQAKDVKKFKIQRRVAVSEDSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYT0</accession>
    <name>A0ABM0ZYT0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase B1, membrane-associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937326.2">
        <property type="nucleotide sequence ID" value="XM_013081872.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011621"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937326.2"/>
        </source>
    </evidence>
    <sequence length="162" mass="17635" checksum="49EEFD8FF7165730" modified="2025-10-08" version="1">MVTSGQFDTSDDFTVVLQPMMRELEVPRLPSGDVDYSLMAADCFHFSRKGHALAGIGLWNNLMQPVGKKAAFVDFGTTVHCPDEDRPFLATRRNSVLGLQLGADGPSSNSTTPRASSSKSNTTKKYAAPVVAISALIAMSLVATGLAFWRKKTNNHRLYEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A113</accession>
    <name>A0ABM1A113_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Radial spoke head 10 homolog B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101856966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012938645.1">
        <property type="nucleotide sequence ID" value="XM_013083191.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856966"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46613">
        <property type="entry name" value="RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46613:SF1">
        <property type="entry name" value="RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="676"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="808"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012938645.1"/>
        </source>
    </evidence>
    <sequence length="865" mass="97730" checksum="902B499BB53D9071" modified="2025-10-08" version="1">MIGSYTHSEIFELYLKLYTQILFIKGLKSFCSLLRLFIPLSNMASKEKKKGEKRSGKKTDAEEEKKVETPVTDCVDTPSEDATNAEPAEEPPRDPTPEPTYDEPALSELIVESFEGEKVKGLYEGEGEAQFTGGHYYKGMFSEGCMHGKGVYVWANGTQYEGDFLKNQVTGKGMYTWPNGSTYEGDVSNGKRHGFGTFRSADNRLSYSGDWVLGKKQGKGRMDYDAEGKSYYDGDWVNGIKHGWGTRQYPSGNVYHGMWFNNVRHGEGTMKWLDRDQVYAGQWENGIQHGLGQHIWLLRRVTKSQYPLRNMYDGELVNGLRHGTGVFYYANGAKYEGYWRDNMKHGQGKFTFKNGRIYEGLFEKDHIVEYPDFTMDGSASPDMTQIRTRTPVPTDNVSVHSNDSKNTVSPSFQLEIHTLLATLPADDVEHEVSQVLYSITRHVSALRRIYTYYSMLGYEESPDNTFIMNKMQFWRFLKDIHLHHDRHMLTDMDRLIGANYHKSNYELHNPYEKILQRQFVNYLVILAHLVYKQDYKEKNESGPILEYCFSRLITEKVLRFACMVKSPIYCETRRATNALVHMDQAYEIYQGISTLRKHAPREPMLKMRNFMFLLKELGLVNQDLTPAKILEVLGSDNPGVSDGEGCYNLELEMTFLEFFEALVGCAEVFVTENVVKDPTTPRPSTAMTHDPSMYSVPASPSRMTSQGAGEEGAESVRQQTPFPPSTSPVPQSPVRNASSVALTNKTGGDESNKAGEGSTMNLPGDAPTTKSSQPGSVRQDLPGEMQKSASFISAHTGSEENQPLMQSSVSLIGPDGQPIDNEEDSQSPEHHSKCHSGSGISYIYCFWGACFLFFLFHLNVFVVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1I3</accession>
    <name>A0ABM1A1I3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synapse-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938941.1">
        <property type="nucleotide sequence ID" value="XM_013083487.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846357"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF6">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012938941.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44049" checksum="F8CFDDDE782AE388" modified="2025-10-08" version="1">MFSSVTSWLGVGSRPKEEEENKENEGHVHSESKDSISSTSVETSVSSKEGLTETESEGEGKASTTSESSQDVSPLDTLEDVSAKALSTAKEFGNILFSFGKAASKTVADTATKIKHTVEEKTILGDFSKEQDKFVEAKKEKVKQEEAAVSPWVGYNDEENLKTQILALSQDKRNFVRNPPSGVQFQFDFNSCYPVALATLQEDKNLQKMRFDLVPKVVNEETFWRNYFYRVSLIRQSSQLASSLAQKSGKSSSSSSRRSSTGSEQKESTPADKEEQKAKEEEALVGSPPTQDEFVSDAFGESQISEEDIRREMEQQLRAAAGTGEPGKELLEGDDWKKELQEKLLEQKGEDWEKELQQELQDYELVGGENDDEDDDDALEKEILQQIEQEANSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3S3</accession>
    <name>A0ABM1A3S3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THAP domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106012292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940239.1">
        <property type="nucleotide sequence ID" value="XM_013084785.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012292"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP9-like helix-turn-helix" evidence="3">
        <location>
            <begin position="133"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940239.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24879" checksum="F21F6390AAA02273" modified="2025-10-08" version="1">MPKKNDKVCSEHFLPIDYVDGKERHTLNGKAVPSKFPGYPAHKQQADKKRPSPNKRKLPLPEEPSPKRPTLNPSVSVGLDHTYHSPSTEVKVQQLQKKWKEACGKLKEKNREVKLLSEKLKRRESKISTLLEKLQELKLINEEHCEILKENFPENTFLLIENELAQQGKLKSQLRYSDEIKAFAVTLHYYSAAAYEYLSTFLHLPHAASIRRWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4C6</accession>
    <name>A0ABM1A4C6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylcholine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940595.2">
        <property type="nucleotide sequence ID" value="XM_013085141.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012362"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045750059" evidence="1">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940595.2"/>
        </source>
    </evidence>
    <sequence length="232" mass="25925" checksum="CE4ED5D70E1184FF" modified="2025-10-08" version="1">MARFILLCIALTFAGASSESRYLELYNWVSGKASPAFPQPDNSGPLDVDMRLTKLDVVDVDSANNLVTLIARRRVLWADRNLAFDQALFNVSCVYAAATNIWTPDSTFYNSASQEHVLNREVIVFAGGELLEIERVQVTINCNVKGVNTYTGATCHLQLGSYGLGNELFRLREPKDNWTFHLESAFNGASPYELLSGDVSRSVEPYASGDPEQHYYDALTFTFSFRRKWGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A658</accession>
    <name>A0ABM1A658_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protogenin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101853021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941575.2">
        <property type="nucleotide sequence ID" value="XM_013086121.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853021"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF43">
        <property type="entry name" value="MYOPALLADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="127"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="217"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="314"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="411"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012941575.2"/>
        </source>
    </evidence>
    <sequence length="461" mass="51270" checksum="75DDF569561F68F5" modified="2025-10-08" version="1">MDGLYVCKVKTTKGILIARRVHVVMSVMARNFSQEPASREAYQGGVARFTCDIKAEPPTSYEWFKDKKQLSSERFHTLSSGILQISDVQDSDAGFYLCQTTSYLHDFRIKKSGKAELRVLSDVSERPARFVAAPANTTVTAGNTAELECLVDGNPKPSVEWRRKDTDLRWRGQALSGPGNLVLTNVGPKDEGIYECVLFSRGLTKTAAAKLTVQVAPKLEQGLESYSFPVTKVMTTACLVSGSPAPNISWYLNGELIEKTGLYTERIKKTGGESMILYTLQKKHSGFYQCVAENGVDQVMSVAFLQVSQKELAPRGRPTNVTAVTTSTSILVTWDNNLVQSDRPSVVAYQVVGERFPRQKICTVKENTWSQQCTVKNLRPATNYSLTVQAYNKYGASDLSDIIYVQTLPDVPSKLPEVSVSSPEFHSMLISWTTLSAEDSRGQLQAYRVYYRRIGQNEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A661</accession>
    <name>A0ABM1A661_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012623</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941578.1">
        <property type="nucleotide sequence ID" value="XM_013086124.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012623"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046097738" evidence="1">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941578.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22476" checksum="4B23308F394AFC5D" modified="2025-10-08" version="1">MKGTTVTSLALLTTVFGVCLAANDTANDPANEMTNVTETDMGDMGNSTTNMAPPGCLGRISQCVMSSKLYVNATDGRISCEKYKGLKGCATTDNNGSVCSEKEFKATSVQTCLFEKVMGLKDDITPACLTKLDSCGDLTILQNGMKSDDPEKYFCDYYKSEAFKNCFMDECSDNDYSLFQGEVCSGCQVLAGTLWTGLLLALLAMMVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A743</accession>
    <name>A0ABM1A743_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942147.1">
        <property type="nucleotide sequence ID" value="XM_013086693.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860193"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942147.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15664" checksum="0036E42A0DE9F468" modified="2025-10-08" version="1">MCGRLCCPFRSSNSDSKTDLEDDLTRILIFGVTGMIGSAVMEATLSCAWFKITGFTRARDGEILDELVSKGIDVISGDMKDPNSLLVAMQEIDVIFLTTHYWETMSSENEYIQVGGASFVLNAGWLISRCCCCSSYFDRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7S7</accession>
    <name>A0ABM1A7S7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Degenerin deg-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC106012858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942490.1">
        <property type="nucleotide sequence ID" value="XM_013087036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012858"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012942490.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50680" checksum="798D1535A32CF260" modified="2025-10-08" version="1">MGLFQEFSESTSMHGLQRAVSSESKWKRPLWAALVLAGACLATFNLSQTLKDFLHNPTTTQTSVHYNPDMEFPVITICNLNPFRSSLINAVTDSDFIENLWRNPGNFTYEDVVDLTWQYYKMKNVSVTHQLEATVMTCKFGTGPRGYGKFLPSFNLKYTTKPGPSNGLILELNVQQSEYLSATESAGFKIAVRPRDTLAFPEDQGLIVMPGTNTNIGLKKVEMSRTPPPYSACVELTDEPNVELNMFSFTEGTRYTAEACRKTCYMRELVRQCGCCDLHFICPPEIYNNISFCNATNTDEFVCKKQVLKMFEKGELDCLSRCLPPCEEVVYDVALSTAIWPSNNAIPYKMTALGFDQANLNTAMSEMKRNFLRVAIFYEDLAVRRVESRPSYDWNRLLSDIGGQLGLWLGFSILTAMEWLELAYDAGIRATTRMSLGAQTTRAHGQEQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7Z7</accession>
    <name>A0ABM1A7Z7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pancreas transcription factor 1 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942586.1">
        <property type="nucleotide sequence ID" value="XM_013087132.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859884"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19686">
        <property type="entry name" value="bHLH_TS_FERD3L_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF112">
        <property type="entry name" value="48 RELATED 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="78"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942586.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25718" checksum="28F1191320D21F40" modified="2025-10-08" version="1">MEGYVCGLSEGFFEFCGSHGYSMEPSYPYMSDAHMYTDFPDFQNDPYLDSPESDQENCAGYFEPRLSGVGDGVPKKHQQRKAANMRERRRMKSINDAFEHLRRRVPANTNADRRLSKVDTLRLAIRYISYLSELVKSCGDLREGSKHKHVQKKIILRCHVSDGEDGDMGNGQTVIGHSLSWSRRKPEVNERSTLTAKIWMPGSPTDSDLINLTSCSHGLDPSFSSVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A842</accession>
    <name>A0ABM1A842_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101850593</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942645.1">
        <property type="nucleotide sequence ID" value="XM_013087191.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850593"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046568778" evidence="3">
        <location>
            <begin position="25"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942645.1"/>
        </source>
    </evidence>
    <sequence length="780" mass="84111" checksum="708C4759816C3095" modified="2025-10-08" version="1">MGTSPHRSLFVVLFVTLVLRQANSANCPNPAEEGGSTIIMFTVPDASSTSSSFTWLAMNNIQDLVTCCTGNKTCITTTGFGTYPTGRFSSSPSQITLELNISGVTRSSPPFNMETEWRLLDDRRHTVYSCDLIVYKKPSNVSCDQPRFSGDNSSVSVTCETDRVYPQALCQFYRKSSAWEPGNPIDNTGVQYSHTEVTSSSVKYYRSSCTQTVPLSSLQAGDITFTVNMYPEFPGSDTSYGITNVGSPVSITLSYPTVTITSCPVVVDSANNYKGGYIREGATFTCQCNLAHSGNPTGEIDWLNNTGHIVATGNMLPNGIAKPGETFTCRGTSPIGIGYNPLAKETYSPNVAHGPTQVTVSLGDGHGKSRTLCPLQNLSIPVVCQTPLVNINPKPRCSILVTKSGLTSYTEDFSTDQGQVQTEQYTFSSDVPVTEAGDYVVTCTMYNSVFGDLTHSDSIELSVTDPVISHPVFTVNGIVRDEQIVHGDNVTVTCSDTGVIGEGFELLCTNNSVSISQHDEDKIEFLSIRTADNGTVCVCNFSSTQGCLLEGTKTLRVTSTPSTSALGGGDSDFPTTAVAVAVAVIVVVVVVVLIAVLLIKRRKQRRRSSKLGHHRTETISKTGKGNQLYDDMVIVDNSELYGIPGDETVTVDNSELYSTSAHTNGTIDHEDEVQDEFEPYELIDKPVKVQKSSPGTTPEARSAPTTTQTPKQKKPPIAPKPAILSNPMAGEKSPQQTDKVGPGQHLYENVDKARPTDSRDLEFVGDVYAVVNRKSQQSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAN6</accession>
    <name>A0ABM1AAN6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944074.1">
        <property type="nucleotide sequence ID" value="XM_013088620.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854538"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="267"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012944074.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40602" checksum="4B31309A59BEA86B" modified="2025-10-08" version="1">MADNSEQNVGHGQETTLNEVPDQLDRLCSLKEADISENNSAVNGATTKEDCDADPTGLSETKPQDSLLGQKTVSPKKSDLETSPAKSDSKCTNESGVSTNSDEEFHSADEGSDSEEDSQPVPVCDDAHENNAGDFIPPNMDDDDDESEDGDEEKKEQSETEVTEELEARKRLEEALTAEEVEERKCNGQHLKEEGNNKFRNGEYDEAIESYTEALSICPLSFLKERSIMFSNRAACKMKKELYDSAIADSSSALELHPHYLKALLRRAELYEKTEKLDEALKDYQQVLELDPSQHAARASCVKLAEQIKDRNEKMKDEMMGKLKDLGNLVLRPFGLSVNNFQMQQDPNTGSYSVQFQQSPPNNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAX1</accession>
    <name>A0ABM1AAX1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101847290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944207.1">
        <property type="nucleotide sequence ID" value="XM_013088753.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944208.1">
        <property type="nucleotide sequence ID" value="XM_013088754.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847290"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF12">
        <property type="entry name" value="DEFECTIVE IN CULLIN NEDDYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="34"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012944207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012944208.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27198" checksum="843D3850987D992A" modified="2025-10-08" version="1">MPSRRRRREATVPDEVAPKRSRTQTPSKDTATEFSKKRCLTWFQEYSGPDDDCLGPEGMEKFCEDIGVEPENIVMLSLAFKLNAKRMGFFTAEEWMKGMTELQCDTITKLQNRLDYLRALLSDPTCFKNIYRFAFDFARDKDQRSMDIETAKAMLSLVLGKNWPLFSSFHQFLEQAKYKVINKDQWCNILEFSRAIQSDLSNYDEDGAWPVMLDEFVEWLKDQRGVSGESGMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABD2</accession>
    <name>A0ABM1ABD2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-like protein 40b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944448.1">
        <property type="nucleotide sequence ID" value="XM_013088994.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849413"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012944448.1"/>
        </source>
    </evidence>
    <sequence length="556" mass="62923" checksum="B4736C1D6DA632A3" modified="2025-10-08" version="1">MATVDRIARGLLQGMKLQLDRDSFHDFEVHVEGETFRCHRFILSSCSHFFRGLFNSGMKESETDSVVIEEISSETFRDVYEFIYSGRNVVNSENVSRLCFAASHLLIDVLIQECELYLQKNLTQHRCVEVFNLAKVLNSQKLSSLSFEMMRKRFNFIRRTEDFLSLDECDVKQLVACEDLPIDSEDEVLEALQRWCLVDSEKDCRLQALSNLLLSARTCLASSSCLQNLLDFDVVRSNKEVTRTLQEALNYHTLPGSRHNYLPAQAVHREESTQQNVLVVVEPGSKEDEEAEKAEEEKEEKSRVCQVVAFGDFMFGLNTNHAAFLYDLKTGQSQSLPSLVKPGGDYKLVSHGLYIYAIGGDEYDNIERFPAQEHIVNPGSAEWEQIGNLVQPVRNTAVMVVNNSIVVFGNDMSSEQATVVQRFNLLTMRCSQFLDEMPGHAESAVCLRDRDNHFLLQQDGSLWRLVACNDSNLQMVSEGSLWEDNIVLCGAIVCKGELIVLGKLKDPDAAAVKQWKLKENFFFSKVCVLNLAGSGMINTVVPKEMRSQIMQCIITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABR8</accession>
    <name>A0ABM1ABR8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatase and actin regulator 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101845131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944679.1">
        <property type="nucleotide sequence ID" value="XM_013089225.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845131"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036218">
        <property type="entry name" value="HIVI-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021567">
        <property type="entry name" value="LEDGF_IBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11467">
        <property type="entry name" value="LEDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140576">
        <property type="entry name" value="HIV integrase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Lens epithelium-derived growth factor integrase-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012944679.1"/>
        </source>
    </evidence>
    <sequence length="764" mass="81188" checksum="B57C865A94E125F5" modified="2025-10-08" version="1">MDAEIKKALNLDNLDIDKCVAILEDLSAVPMTVVLLKKNPAIVQTIKKIRKFRGSEAVRCKAELIYNRFKSFFLAEEIPGKLLEPKLKENKENEGQLSQAGDTQTDTAPVVEGNKGAGSVSEPLTLIETQATAVVSSTGDVVPPTDTLTARPGDAQTVGGAALTAGPGDAQTDTQADAESARPDTSERVGQVEGESGAGVTGPDTPAVDRPDGAPPPTDRPLLPSPSPHSLPAQTSSGEDTTSGLVTSTSDPATSTVDPCPTTSTTQPEADSSESAITSDSDTRQPPPAANILPGLDAIFSPQGAGESHGRAAPTTSLGDNVTSLPPADVLTQAGDAASLNATAAASLPGDVTSKPSSDTPGQRSDDTVSQTANPSSVSSPSSSHGQSGVSVAAVSGGARGPDSSHYDPRRPLSLPLPPGAGEEEEEEEDDSIRLNKYVIDPDMIHPQSPYEAVLASEPDLNKRPQKSALKKSGLVGAGTAGGLNAASSWTARPLDTSRASPTPGAGPAGAPLGGGSAAGLPRHIEGPPAHVSPQSTPVGTVRPIPRPRVSIQATGDNESDKENSHPQVQEQPDYDNLGDSDSEDEEIRYKDDYDPNSLAAKVARNDSLARFLDNRPTKHDLVAKNIIPDLTDSQKKELREAVGAKLTRRLSLRPTQEELENRNILHQQSTAEQRAEKERKKRYLIRKLSFRPSIEELRERKIIDFSDYVEVTDAHEYDRRAEKPWTKLTPRDKAAIRKELNEFKSREMDVHEDSRHLTRFHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACV1</accession>
    <name>A0ABM1ACV1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945259.1">
        <property type="nucleotide sequence ID" value="XM_013089805.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847161"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945259.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23059" checksum="76FB02608AD4F1FD" modified="2025-10-08" version="1">MVVLDSVTYIPECLGFLVLMVLVIQLFLTLRAKVMERLHHYSLARDPATHNGAAVKKLSNSGIPKSSSNTSINGAAPSPKSVSYSKQDVCVTTFSRNNAKIVTSQAELLLRNIDDSKTFVKPQSCVIESLDILCECPKSKLYLLFVDAASCGTRPDDVTTAAATTTTAATATINSEPKTTTADQPDLTSQPAILSQTELLLLTVRHVKSMGGLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADH4</accession>
    <name>A0ABM1ADH4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106013709</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945602.1">
        <property type="nucleotide sequence ID" value="XM_013090148.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013709"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046804134" evidence="2">
        <location>
            <begin position="33"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945602.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39139" checksum="E9E6C84BC74AA3BB" modified="2025-10-08" version="1">MGRWGVTASRWSCMSAVCLILATSSYSQRATAMQLFDTNRMPKEAELVPIDITALTFASPRSRGLNGESRADESDDHMPSSLEVDFICRGKRQHFRLEQHSGPSSPLTPKSDPGEIPLLTRTSSTGPVHVDHIPRIFSRHCRTYQDKDSQAVFLVIRDFEFSSFKLFGSFLMSDGQFFIEPFNSSNSKDSKRLHLATSTPNLDFSSDSGSVLLRTEGQHLKKLKKRQTFAPRRDSRRQEQQTGSGNGNRNGSRQRGFVRAQREAMFNYEVEVIIACDFLCYQRFQTLYDITDSLKTKNVIALYFSFVREVLKISYASVHKLYPEMNMDIDVSVPALFIADSPDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFM2</accession>
    <name>A0ABM1AFM2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 49 member A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106014170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946701.1">
        <property type="nucleotide sequence ID" value="XM_013091247.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014170"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="52"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012946701.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="28401" checksum="1CED21CDBBFD7B7D" modified="2025-10-08" version="1">MENQEISDKMGQGRERPEDNEPIIVTENVLDQHYEYLRDPSGYTVYTRRWFLLFVIAVINFTNAMIWIMFSPVTDKTSQYYGVDPTGVNWLSLVFLVASIPCGFMASWLLDTLGLRASIICAAWLNFLGSVIRNLTAYSFMPHSAQFPVLIFGQVVAACGQTFVMFTPAKTAALWFPDSQRTIANTLASMSNPLGILAANVLSPALIKKSDDLPVMLYICTGASLFGVLLSTFGVCSSVPPSPPSPSAAAQSEPFFLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQG4</accession>
    <name>A0ABM1VQG4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protocadherin Fat 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101851025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824656.1">
        <property type="nucleotide sequence ID" value="XM_035968763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851025"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1357"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="3"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="221"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="287"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="390"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="492"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="599"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="704"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="811"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="912"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1015"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824656.1"/>
        </source>
    </evidence>
    <sequence length="1386" mass="147431" checksum="14F4C8C79F953B3F" modified="2025-10-08" version="1">MAGTSVFEVTASDKDSGLDGEIEFIVVNGGTPFSVDSGTGVVRVAANLDYETDTSYSLVIRARDKSTATRSVAEQTITVTVTDVNDVTVTCDSVATQVIPDPNSVNYVVATLACSDIDDPPTAVTYSILSEVALPSGTTTAVFSLTGSNLVLTGDPQNTRYLVTIEATDGTNSTQVEIVIITETQLRLTALTSPVTVDEGVSGNTLHIFNWTDVFPFARVTITSGNDDNKVILYSTSGDLVLLSPYDRETTGSYNYFVQASTSSNQVATTTLTVEVNDVNDNTPKFESSIYFVSISENAIVGTTIITLTATDLDSAAFGPVAQSIVSGNTDGDFAIDPVSGIVRQVKLLDRERTDSYTLILKATDQNNVSSTATLTIAITDINDNDPAFSQPVYEFNVDHNTGMGVSIGNLSVVDADDAVNAETDVVIDDAGVTGIFSLSGLQVETATIMDYEVVRRYSFQVKVTDKGATSRSGTARVVVNVLPATEEPKFDPVLDTITIDEGTLAGYQVYDLDATLLGASETDGTMKYSIMSETPAGGFTVRSDTGQVVSLVTMDYETSAKYDLTLQACIVLDCSIKKVDFTLTIAVIDINDNTPYFNDGSYSIQVEEIVNVSTVLDTIITATDEDNSSPFNVLTYTLTGTSTDFELVDSTSGAIKVANSLNFQSQSEYSYLLSVSDGGTPAKSAQVSVVIQVQDSNTNDPIFTTGSTTTVPDSSPVGSDVFHFHATDADTGPAGELSYGIIIDSSGGVFSLDPSTGILTTGQLLDAAVVPSYTLTIQVEDRGTPIRSAQSTLTITVESTVPNNNDPVFSPTVINVGLARDATFGTLVTTALASDADNGNSGELRHKIQAGNSDGYFAIDSQTGQITTVTSVLLANDAYTLTVVAKDNGVPQRSATATVSVVISPPKTTLTTVDYSWTVTENEDANTEVGRIDVDTGRTVTGTYAIELGNFANTFKISLNAGDSRGILEVNVPPDYETKPLFSLLVKVGTDIGDVYKVVQIQVVDTNDEPPVFAQSSYTLTLAENTPIGSTVETISYTDADSDSANRDNILEVKAPGTSLFTIDQLGHLTLLTSPDFESMSTPITFDVTARENKSPAVTATTVVTVNVIDILEEETVPSSDVTDDALISLELPYQSSNGHVLHTFKPGDFGIAESATATVEYVTVQAGDPFTIDTTGTITVTDSTLLTDATKYIRWVICRSTDGGVVTSRLSLIRIDTFDRDTQMIVIEFAESLTNLRNNIVNFKKRTQVFFSAPTRVGFAQTFDTSTSGARRRLLATQSVAYAYAVADTSADDIANLNQNKTFMTQEQLLAILQQSADGSPVAGLSDPSSLTVSTVQPFGSTATSNSFWKTPAGIAILVLITLFIVILVGFAVVCLLYRREKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR05</accession>
    <name>A0ABM1VR05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable serine/threonine-protein kinase cdc7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824847.1">
        <property type="nucleotide sequence ID" value="XM_035968954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477446"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824847.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="39919" checksum="819C730E3213DB74" modified="2025-10-08" version="1">MHEQMSETFSDSGCADVTAGSESRMNAESPYRSVSGGGGGGSGVGGGGSQKVGGFNSDSCNSNNRDSNISNTSEPSGQGSELNLSPNRGHNNNNLCHKNSGCSTSLEFKEDSDDDDDEDDADDDEVGEEKSNFQELQNMEHHHLTPHHFLVKEHQQQQQHQQPQYAMAVHPHPSHLHQRLKVSVDTNPSDPCRYSPVPDPSGQLYGLQSVMNLSRSFLGQPDSPFIRRGDREHAVKSSTDNNNDDNNNSDNNTNSMTNPSDDIQMHCGNMSFEERVGLNTDHIYPNMPLDCSSADQPHQNAFLLHADNQLANHHRPHPHEQHEQQQQQQQQHTRGIPPAHGLVTRNQWKGYTAVLGRLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRM7</accession>
    <name>A0ABM1VRM7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101861723</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035825069.1">
        <property type="nucleotide sequence ID" value="XM_035969176.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861723"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
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        <property type="entry name" value="Chs-1/2_IV_N"/>
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        <property type="entry name" value="Kinesin_motor_dom_sf"/>
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        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF42">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23000">
        <property type="entry name" value="ChitinSynthase_IV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="705"/>
            <end position="733"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="754"/>
            <end position="777"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="789"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="823"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="860"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="969"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="1014"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="1042"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="1570"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="1606"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1630"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1659"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1691"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1945"/>
            <end position="1964"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1984"/>
            <end position="2006"/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="348"/>
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            <begin position="420"/>
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            <begin position="371"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="616"/>
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        <location>
            <begin position="1835"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
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        </source>
    </evidence>
    <sequence length="2243" mass="254867" checksum="6796DBF59E71F9F1" modified="2025-10-08" version="1">MQSVFKLIDLADDEEEDVYYILAAVLLIAEVEFKEEDHDTVSIANQEVVAKVAVLLNIDEEKLTAVLIQRQGRLGSDNETIYEVFGARDSRIAVDSFSSASRGSVVGNRRSWRPESIRGIIEQGEVIRYSKNKKQAEEERDSLAKALYERLFGWLVQRVNKALSPSDYHSRSTSIGILDICGFENLVGENGFEQMCINVMNETLQNFMNRHIIEEELQILKYEGVDVGEVDTDKLNNDLILSMFQDKHGLLALIDEDSKFDIASSDDKLVRKMNEKFRKNEKYIPSTHDRPEFAIAHFAGDVTYRADNFLKKNKDALSDMMLDCMTSAKDGLVMHLFRAKEGLTGTISMSQYQFPNESRRPRGSLRPRPSNFSHTHNLSESINQSTRKSLFQKFGDKRPQFKKLDSQKKTTHITFFKNSLQDLLREMQSATAYFVRCIKPNDRLTPDRFLRDRVIEQLRYNGVTQVARIRSHGFGHQIPRTEFKNRYQDLVDSYGLEGEGQICDAILNSVCPDPNMYKVGITKVFLKEPVYYDLRTRLEKVKEEKRKKEEEERLKREEEEKRRKKEELEEKRKRQREQLQVELERERQTPIAVGTSRIGRSVAWFDDLNTIQEAPHSNESSIYNRTDSASQSYSASLTPSEPNSRKDGPPTDKENTAVKDVHTAQGDETKEEDAFTGGWDIFSALDEEEDKPDVHEQPVLMGVKAVIYILFFIIIFAAVVCQKISLLVLVQDVRSTNLTGADRRDIIKENTHKTVAYILLIIALCIPPGLALLISMAKLCFGSFKSPSIWTWILVCAMECVQTVGVVLLVFRVLPELDSLRGALILNATALAPALLKLVMAKDNSKKRVAGGLRCASVALDSLCVLVQAAALPLIIVLDYIPEGIQNQKPISEDPRRAVELLGALVLVNFCHWENFVDGRFLCFGNSESEETGGAVSDAPSAQEGEKKRNSGFSNAVLKVRHELAEGRFYPYVVANLLKIGLIVWMSFQLRGDVSFKYSRAFRYLSWYYETPNAISPIITITISGFTAFLTAFVACTFQMQVFSVCVPLLLASPATVLILYLDCHYDFLSVLTTIDRSCSWNVWDEYFYHVLMGVAWWVSVVVLTRHIWKPVVDRTANMDRLLVNPSYCPVLTGESIMLNRKRQLAKVVEQVQMNKMGERIGVSYKLSNNVKNKKEKEENVERPTDLNPSAEETVPMLYACATMWHETKTEMVQLLKSLHRLDRDQYVRRYAREQHKKKDPDFYNFEAHILFDDAMELDDNNERVPNRWVKDLVQCMDEACSSVHGKPMKVHDPLKVPTPYGGQLIWMMPGGNLLYVHMKDMGKIRNRKRWSQVMYMYYLMGHRLVMQAKKVALEQLRKINQERGGHGLNIREINYLLGEGTAEKSYNTFILALDGDTDFTPGSVKILMDRMKDSKVGAACGRIHPIGNGPMIWYQKFEYAIGHWLQKAAEHVFGCVLCSPGCFSLFRASALMDTNVMKRYTTEPTEATHHLQFDQGEDRWLCTLLLQQGYRIEYAAAADAWTFAPEGFNEFYNQRRRWMPSTIANILDLLGTATRTTRLNPNMSRPYIFYQWLLMVMTILGPGTVLMMIAGAIKLVFQLNLIESYLFATIPAIVYTVVCFWFKSKVQLAFAAILSVFYAFVMVVVFVGTLITATTTQVLHPSVIVILLLAGIFVLAAVCHPNEFWCLPHGLLYMVVIPSGYLLLVIYSIVNLNDVSWGTREVPTKAQKEENERRKKEKEELKKQKKQKSLVSRIFGRGEEHIRELTTLVKTLFPERGPQQAGADEEAGDLEAGTLVRDKDLVKLLKRIEKNTRPPSHRSDSSDDDDEEEKQAKTVAQQPSQHAATSTPAAPVVQATPQTSTEPAPAKESPGKPQTKKSTRDEMVNPLWAEDKGLGQERVIKGNAEEMIFWRKFINKYLLPIKPSADEKKKIADELRELRNNASFGLIIINLLWMAVNFMFQLTTAAKVTIPTGHGNGTVEESALGLSFVGLLLILMLTQVAGMLIHRMGTLQHLLAITEIKIKRSSGRHQEDGEDTSIQDAIRHIKDVLRMPAEDDPGAVTEAPEIADERTAFGETVVGASTRRLPFDESQQMNQTIKKIGTILDAGRLNQTLDRNTSQTLNTVRRRLTGENYRENLGLSIRPELPPRNRHPRGFLQSHQFGFTTRELENNPVFARDDSGTRRDPNLPRDAMGKSLFQRTRIIKAVTDELMPNGRVHFGSEDIPGLRSNGLFDTDIENRYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRV9</accession>
    <name>A0ABM1VRV9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101855484 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825151.1">
        <property type="nucleotide sequence ID" value="XM_035969258.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855484"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417:SF7">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN EAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE LMTK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045038044" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="116"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1214"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1531"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="984"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1227"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1342"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1359"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1425"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1469"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035825151.1"/>
        </source>
    </evidence>
    <sequence length="1577" mass="169057" checksum="E0176B92B3A905EB" modified="2025-10-08" version="1">MVLVVIASVALLLCMVVIVLGCLNCLQRKKPGFSNFNNASPSRDNQLAQHNAAFTVDMSDVEASREAVVIEPLPDIITKATDMPSLRPRMMCLERGKQEATLSLISIQRSFPREDLLFLDEIGSGWFGKAIESEALRISGGTLKSRVVVKMLKDDATKVEQKQFLDEVNAFRCLEHANLLSLLGQCTEAAPYLVILESAPHGNLKTFLMENRPEADSLIKKNQLISFALDIGSGLACLHRHDYLHNDLAVRNCVVMGDHNVKIGDYGISDVLFKEDYFDTGKELLPIRWMAPESLIQTEGVWTAQVSDKTSDVWSFGIVMWEILSLGEQPYSMLSDEAVLQGVVIDRLLLPQEVDTRIPFKEDLSTIMTQCWKNPGERPDIEQICHSLNQLLRQRVDTMDTMNDFDQKWNFLVPSRGASSSGADSLAGSRTALAGSFATVNSSSPEEASVMSDGAAVNTTQEAAAFVGAGFESQGISTSTPVSSKGKVQEMPQAVAAIANDIGDSRAGKIASAAENTSKSSPQDDSIIIENEVSRIEETRDTFEATVSSPSDLLMVTTSTPKNQQSQNSTAQFYSAESSRNSAYMSAMEKISSPEPSDNAPELLQGIGQDFSLDSNGLSLSEFADNTLQDPTPEVSKNYSNITDLDDLVMSKVEAKETADEETGDQFGDFVQTSPTAPRADFTDFEKASIGASSAGGVSEEFEVIEKTEAAEMETASMNDFSDFVVSANEEKAEQNQSSISVNNTAKDELADLSFSSTTGDKSADTVLPASSLSSTSHDALFITSAEVDPSSSLDSGLLTSDLSAQEQDAVKIEVSSTDPGSKEETEQNIFSENVSQGLEEKEVFGFASGEPEIPPQSSNNNSLLIGFGEDDLLSTPDPSLKSDLSLIPDPEGFLQFQASPSKPEESAFPDLIVPISENTQNFAPLEAEVPTVKEALGEAQRDLLPALNESNDFSFIEVGDQPPAAATSLTDQQQDLLLIGDTGSEKVGTDSKFESASSHSPESESGINSRSVTESLSNVAPTQDGLDSSDSLGFVDTSDPTGDSVISEGHSADQAFPESADFRLSPPSSFSGSNLYRSSHILLAKSNENLLIDSQNQESEPVVREKSPDPVESPEDSDSEVCSDSSETSSTSGSGKEYNCQEDVFSDTGQPPPSPHPQASSQLNSVSSNCFDSEEAPESSSYGDFDEQALRIASEIYLSKGVKSSRVYEIPPLETIPEHQPMPAISEDPVPTPSSDTSSVEVKYDDLFSSDGYEWDDFFDDPLMGKEMEGNHSFQEQQPLFRDSDVSDWSLDIDSESIHSSSSLQSRISEDLPVNKSTMSDVALDNSLDSDKSVRCKSDSELLVSSSASHSRGRTISGKSLVSSILAQRSINPLTGSSQRRPNTETGNTSFYSFTEDFDTDTDTSSEGPLSPTGASQNTKPQEPVSSNSSSISLPSLPSIPSSSSPVLLDSSFLSSPHIGPPTPAQFSFPSPSSSHSSFISEISEVHRGSPPDVLPGPSMGSDLWLEKTGATAPSAQINQDISSDLMGDLLGSAPSLAESVGSSDNETLAAPKEDDAGDSEQAATTESGVGSLIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTF8</accession>
    <name>A0ABM1VTF8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825700.1">
        <property type="nucleotide sequence ID" value="XM_035969807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477157"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035825700.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12846" checksum="D1B5D4B1AF3156FE" modified="2025-10-08" version="1">MCLVKGSVSHPTEDGGFPLIERETEGHTRVESQRRCCENQTVQRIREVTPKMAPLSRRDYEELGQEAMEKLKEYQNSTEGWKVVSKTKDGVLVESKPSDVFQGGNMQVKFTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTJ6</accession>
    <name>A0ABM1VTJ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deoxyhypusine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825738.1">
        <property type="nucleotide sequence ID" value="XM_035969845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847959"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825738.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="43460" checksum="338B6A055B2BAE91" modified="2025-10-08" version="1">MEREGNFQRVPKDLDAQVAEYQVFVIMAEVPKIAAEAVLAKSEPMPEGSEVVRGYDFNEGVNYHKLFESMVTTGFQATSVGRAIQEINKMIDCKFQDIPESKKPDINLNPSGRELTNCTIFLSYTSNLISAGTREAIRYLVQHNMVDCIVSTAGGIEEDFIKCLAPTYLGDFSLSGRTLRSKGINRIGNLLVPNSNYCLFEDWLMPILDNMLHEQKETGTLWTPSKMIARLGKEIDNPESVYYWAYKNNIPVLCPALTDGSIGDMIYFHSYQKPGLVVDIVDDIRMMNSQAVHAVNSGMIILGGGLVKHHTCNANLMRNGADFSVFVNTANEFDGSDSGARPDEAISWGKIKASATPVKVYGEASVIFPILLAESFAGREKEFKDFYAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTV4</accession>
    <name>A0ABM1VTV4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101847424</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825846.1">
        <property type="nucleotide sequence ID" value="XM_035969953.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847424"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046613920" evidence="2">
        <location>
            <begin position="23"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="122"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="503"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035825846.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="69184" checksum="1E831A4894DF6EAA" modified="2025-10-08" version="1">MANHLFLLSLVAALTLPGLILAQNDTTRQPGTSGADVVKAAVHVLREKCVFPNDHLFLRRLAYVLTEDGTDPSTYRPGYDGGIWKVDNDTFHLTLKIVNDDLFEEAFGITWSQVTWDELRKPLYSVIAASLYVISHTPNGQFPVTEDEQAALYHSLFGGSASDFKKNITSLDTGMHLGKQGIYKSTHFNFSVYNSSSSAKNAVLRIPKISGGTSTWLALDEAADTLFSNTSTRPGASRVAVLATDGYSILSMTNASAERLKSKDVSVFAIGVGSGTNLQELNAIASTPKCIHMRELSGFSELASIITDIKEESCKAAAVQKEGSNNTYSCQKETAFSLDVQNGYSVVVRPDSGHVDIYGSFSTSLPSAALSDFSSEAKSNRPVILFIEEKGNERKIYLTVSSSPNKTGDCQSYFELVVYTKNVLSLEVPLVPLCAINGTANACDILTIIKGQLNIGNKTANTTATTSSDTTILPENQTSPFPNTSSPHIKPTAPATPTPSTTHIPCPGSGPGVYAHPVSKTSYVACAEDGSVYVFQCPAGLSFTVKERRCSTPVRYRNVTCTLHDPTVTYPTLGLASDVTPAIFYVRDATGPMYLTVGGGSGSCSGFVNVTRLDGNALHKFDSACFRHCGNFRLIQQQSPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VU10</accession>
    <name>A0ABM1VU10_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101854021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_035825902.1">
        <property type="nucleotide sequence ID" value="XM_035970009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854021"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035825902.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36004" checksum="5DD7AAA091FA233B" modified="2025-10-08" version="1">MWNFYERPFQTPPAQRYGYPQDSQVCATSTPDVLIVVHSEANNFYDRLMIRFTWAAPRYRTINGIHFRTVFFLGVPGELSWKWNSSGTHSSHMTSDLLNLGIKRRDRAGVIAKIKEESKQYGDIVQGNFTEAYRNLTIKNIMVMNWVLSRCPKIQYILKVDTDVVVNLHNVVRFIQHRSHNNTGLLLCSQMKAKPAIRSTSSKWYVTENEYPFSYYPPWCLGFGILMSRDVVQQLYLASRDVRAFWIDDVYVTGFLAMKAGVQVTALGGNHTAQLGGKFKADSVNAMFTLADFFKINTTAFRYWEQLVTSQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUD9</accession>
    <name>A0ABM1VUD9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC101853166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826031.1">
        <property type="nucleotide sequence ID" value="XM_035970138.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826032.1">
        <property type="nucleotide sequence ID" value="XM_035970139.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826033.1">
        <property type="nucleotide sequence ID" value="XM_035970140.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853166"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035826031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035826032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035826033.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="60682" checksum="03F60D61F6680ECE" modified="2025-10-08" version="1">MQNQLRTSFVFWGLKAKGAQPASRCFQNGLSSCGCVRGLSFNKSLQCRDAAHHRNASTTVQEMESMDLNPEPIRSVPKPFSSMPSPKGLPYLGSALEIAKNVGKLHHFHLQRVKDYGPVWREKAGAMDFVHVACAEGVEDIIRCEGATPFRMPIVPHTEYYKVNSRPEGILVSNGQQWRRMRSALEKPILKPSLLSNHVSTMHTVSSDFVRRLDALRNDHGDITDILSELFKWSLEAASVVLYNRRLGCISLEPLPGIEDFIQAATVLNTLMGESLIYPLFVLKTYKRKLWTSFQEAFDKVVAIAEKEIDKIPDDPKAHSLVSHIMSHGNLTSSEMYTNVTEIMLASGDTTSTWAHHTLWELCHRPLIQDKVYQEIKTVVGEVEEVSHSTLGRLKYTTGFLKEILRLHPPVFMTGRELENGGVICGYQVPPGTTTAVPLYAIGRDPNIYKDPMEIKPERWMRTARDREVTNTFAFVPFGWGQRSCIGRRIATANMQLLLIELLRRFRLTSVTKELTLETRLTLTPNPPMQLTLTPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUF3</accession>
    <name>A0ABM1VUF3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pro-neuregulin-2, membrane-bound isoform</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826045.1">
        <property type="nucleotide sequence ID" value="XM_035970152.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845775"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004850">
        <property type="entry name" value="NtA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF103">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03146">
        <property type="entry name" value="NtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045198956" evidence="5">
        <location>
            <begin position="24"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="158"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="759"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="787"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035826045.1"/>
        </source>
    </evidence>
    <sequence length="882" mass="97336" checksum="6AE351F04B75D682" modified="2025-10-08" version="1">MRWCRIRLVLLGLLLCVVHVVSGTCGQTFTDPGSSALLSDLVIEGKVQKQSSTRGDGTYEVSVGIRKKVLKGEELLARRGRHNKRTKRVTVGYFKDGKADGEKCLGEVTVGRTYYFFLKKVPDGAGLRFQLSALPVKKSKKHSRLLRKILCDKCAQSPKIKRLTGPDGVKSGTKVTLKCSAKGIPKPEFSWYKNGKLVTSSRGVRLRTSGKRMSKLQIRKATAKDEGVYECVARNAVGEARKKLEIKVNQQRNAVPCESQTYCLHGGTCMQNVAVGLVFCVCREQFAGHRCELLDAIGVREDYMRQATLQFERTLITVGIVIAVLVLIVICIASYFLAKRRREEFRRRQKSKKNSNARARAADGVAEAHAPAGNRYPPGSSVLTAINVSASPNMTNYPAGQPLNMSFLSHHQPPTGVASQPDGSSIGQPPQEPPTLRSGPRTESNNDMMTRGRLVASSYDNCEPTSPLWKERDHSVRENPEEQVESFEMQPISKMKEPTELENGFADASTRQEPSDSVDLPPPPPYQSPPPPTSSSYPSFSPPKQLEGHGPVGDRFSPTSHIPSSFPSPPASVRDDSSSREDLDTATAAVVKPLLQVDHQLGAEQPSNDHLPDAEMDAVTSPKGPGLSRRRRDEDSGTGYDSDNCEKERLLLESPIHKGPPHSHTYPKPKMNGKGPGLCIDSDDDDDDDDDDDDDVSEVPYKPHKDELHISEEFLNLSEENLIGSSFNSIPTPSRQASYDGGYNDGTIPLLYNMRPEMRKYQSEDVSPRLLSKGRALGLEPGRSRSMDNPSTSDRPSGHVSGNSCGQMNSTLAGSPEEEDYDNLPLQLRKLENPFDPTDDDDSAPWDVNESSQPNFQNLSEEERDRMNRLKHVRPEQEAIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVK1</accession>
    <name>A0ABM1VVK1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC118477905</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC118477905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826443.1">
        <property type="nucleotide sequence ID" value="XM_035970550.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477905"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="63"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035826443.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33201" checksum="614B25FE32114688" modified="2025-10-08" version="1">MSTGKKETLTLQERMQVIKLGDEGNSTRAIAERFKVGKTQIQGILKRKTELTAEFEASAPLAKRRYVKATSNKPINDRLDEWYLDATRRGINITGPMLKEKALEFASHFGITTFSASNGWLQSFTKRNSLAVGKIKPTKCFNKVGFTQPTPDEGDIPDVQVRVPERFDELSNALFGVPFARLPEIDQDLATCDNNPVDWDRPATDLLADLKTEDSEDDDEEDEKSETDSTINAVSTQKALSALRTLRLYLQQQKCLLPSLRPLAFIEEEIIVASRSATKQTTITNFFPKQSRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWS0</accession>
    <name>A0ABM1VWS0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC118478051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_035826862.1">
        <property type="nucleotide sequence ID" value="XM_035970969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478051"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="71"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826862.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30424" checksum="9F2DDA701B8A3A86" modified="2025-10-08" version="1">MLSTDEAAVKQGKNLIRLAFGSPALETNPLVGVHFDLRYGPLNEWLLQLQKDEHRPRLLTIPDHPMQFDLIITSGAFDGLRNALHCLMNEDDSVILETEVFGNVTTAVQLYGTEVGVAHDDQGIIPGHLEQLLSTWPQTHPGRPLPKAVYVITAGNNPTGYNWSEQRMVDIYSVCRKYNILILEDGAYYFLQFGQVVIYNVLNHWGYETFQEKVTAVAELYRKKAMFVEQVAQKHLKVSVRQLTRQRGDLKRESARKILQQCDLSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXL7</accession>
    <name>A0ABM1VXL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer dense fiber protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827160.1">
        <property type="nucleotide sequence ID" value="XM_035971267.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012543"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827160.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24287" checksum="43D7F80BFAD8585D" modified="2025-10-08" version="1">MTKTRVPGPKYTLPPLIGTNNHDPTREKAPGYSMAGKRTYSYGHSPGPYYFDSGITNRGRVNNSGFTLLGRPKHSIWGSSSSSPGPSSSNDYSQTEPSSPRYSFGLPRKINYNNGGPGPNSYYVPSGIGQGRKATIYGRDDKRGFAYDYAKSPGPSYNYGNATYSGGPAYTMGMRTKRLTNKTVTPGPDYYFPTVNGTAFSSPRFSMGIRHHEDVMPLADVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0P3</accession>
    <name>A0ABM1W0P3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrosomal protein of 290 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828236.1">
        <property type="nucleotide sequence ID" value="XM_035972343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013104"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828236.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27060" checksum="9C57EF6595423251" modified="2025-10-08" version="1">MASKIKVTAAAKAVDNRANEAILKQRVKELEEEVSGLKRRLDELRKAKNTTVMRRERELLEVGAPFGRRDSKSADDKEVEKRFAAREKEWQKEMEELRTKFDSQLEAAKKSPVKDDKDCGHWKELTFLRQRNEELENDNAALMAQNRELRERVDSLLADLSVKEATWCEMEEKFKLELKRSWGEKYKEWMDQTEAKITDLQRTNALLRSYLKNQRPGGPDPTGQDRDFDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0S7</accession>
    <name>A0ABM1W0S7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LIM/homeobox protein Lhx2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828270.1">
        <property type="nucleotide sequence ID" value="XM_035972377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850034"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035828270.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19008" checksum="4C7EB80C969E72DE" modified="2025-10-08" version="1">MVVGLGPDNSDRPGEVMDRDGYPHQTPRQKRVRTSFKHHQLRTMKSYFALNHNPDAKDLKQLAQKTGLSKRVLQVWFQNARAKYRRNLLKQQDSDAGSGGKGGQGQGAGSPEGPDKDIKDPNSIPDMNAGSPALSDISSTPSLSDIQSSTMETDHNSSSNNSISDLFSSTIAAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0X9</accession>
    <name>A0ABM1W0X9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiosis inhibitor protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118478570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828322.1">
        <property type="nucleotide sequence ID" value="XM_035972429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478570"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052133">
        <property type="entry name" value="Immune_Signaling-Apoptosis_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12044">
        <property type="entry name" value="BCL2 INTERACTING MEDIATOR OF CELL DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12044:SF14">
        <property type="entry name" value="MEIOTIC DOUBLE-STRANDED BREAK FORMATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035828322.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41131" checksum="1F80A4502A8030A8" modified="2025-10-08" version="1">MLPHAGHCRHDSSWTFIVPGPSKDNQCLLCLIDIMGDMSVSGVQRHVALSMLKGLLEAQDTAWDQMSHHPQLLFHIFDLTTDVYYNEPYTDLAVAVVTFVISATQEERVLKYFMEKCYDIVHCKRQEEPIQFCLLVMNRQCDIDAGNTKFLMLCQAHLLSEILAVSGTLSKTIRKTFVQLLTHVMAVFCSEDAEWPPDVENFVWKIAEAQIPWLNDGDLGRDFHRACLRLLKETLRSRDLRSILIHVGRDVPGDPTLLMGLKKILTTKDEELVLLGVQCLYVVVSSAEDVQQSRDIMATDLAEFVFESLHTKNSLLLSTVFRCLLSMAQHQAFYEKCHAVYGMRLLVLRVDTDSFLGFFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W141</accession>
    <name>A0ABM1W141_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC101860529</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943705.1">
        <property type="nucleotide sequence ID" value="XM_013088251.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828384.1">
        <property type="nucleotide sequence ID" value="XM_035972491.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828385.1">
        <property type="nucleotide sequence ID" value="XM_035972492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860529"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012943705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035828384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035828385.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="58232" checksum="740996801645FD0B" modified="2025-10-08" version="1">MADSGKVKAPDSGKKKNKSQKKRAESSGDGGATPTPSKENVPVTKPASPEGATAAASTGEKTPDVKPAQGAQGPKQGGQNPKKEGKQQKNQNKPEQGQKGKGEKAPPKPEAGEGEQKSKAQLKAERRAIQEAQRAAKATKTAESGGGAAAAGAQGQPSSAGAANAGKKENQGEKSKPGGAAVAVRRIPKKSSKTTEKMTEEQLWAKKEKNLLGKAYKMDHTIVRLGYQYFYHNIVGANARCLALLTTLKELIGKYKTPEEKELSRDLEKNYLTPCISYLNECRPISTSMGNAIKHLKLHINQIPSDMDDKTAIARLQEEIESFIHVNLVMAAKGVAEFAIAKIDDDDVILVYAASSLIAKVLKAAHDSGKRFRVIVVEGRPRTEGKSMLRFLVRCGIMCSYVYIGSASHAMSEATKVLLGAAAMFAIGDMHSRTGNSMIAALAKANNLPVLVCCETYKFTEKVQLQAGDSQMHARSKDLLHIGHRPPVITDHDAMGLRLLNQMYDVTQSRYITALVTELGMLPCTSVPVVLRRQEDLKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1T7</accession>
    <name>A0ABM1W1T7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable serine/threonine-protein kinase tsuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101862758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828630.1">
        <property type="nucleotide sequence ID" value="XM_035972737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862758"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11459">
        <property type="entry name" value="bHLH-O_HES1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="7">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035828630.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="64137" checksum="12E4288A1BEAC5D8" modified="2025-10-08" version="1">MMTESDLVSPTSTSAPHELSPGRMEEKTSYRKSNKPMMEKKRRARINSCLGQLKSLVLQAMKKDNSQYSKLEKADILELTVKHLKNVQRYQVSSSLTQTPDAISKYRAGFNECANEVIRYLGQSHGVNDEARSRILSHLASILTPINTLPLQQAHHHTPILPAPSSSVVAASQQQQLQQQLQQQHHFHLQQQQQQHQQHAAYLSAASQGLTLDSNNNNSSSNNNNNNNSSNINSKSIKLETSSYATHSSAVVKSVGREATAMNLATPTPDVTSANSASPTAFQAPIVSGVTAAPPGGLQLPCIATAAMATGTQFQLVPSALPSGQLALVLAPQHVSALNMGVYTQQQQQQQQAAAATRTPLLHDAAQSLPPPPPPPPAPHSQNQKVTTAGTRIPLLHDTTSTMHRLHQHHHHQQQHHQQQQQQQQQHPHSSVLEDGKNRLPSNLRNESPMSLVTKHPRSPKLTGTPPTTTAVQPSPLQHQEVSQGGGQGERSAAVEQSTAARATVTTSPNHVTSHQASSASSRDSGKKTETDMDTDDNDNSNIHRNIINKNTTANNNNSNNNNNNNKNNANNNVMRGTTKENDPMWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3R6</accession>
    <name>A0ABM1W3R6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829309.1">
        <property type="nucleotide sequence ID" value="XM_035973416.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862158"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056576">
        <property type="entry name" value="MGAT4_A/B/C_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF9">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23524">
        <property type="entry name" value="MGAT4A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 conserved region" evidence="5">
        <location>
            <begin position="82"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 A/B/C C-terminal" evidence="6">
        <location>
            <begin position="370"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035829309.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49139" checksum="B903DED5E987E346" modified="2025-10-08" version="1">MRVIQFPRRKILSLVFVFSVVLLILGINQVFVPAKQDEPDIFENNEQVAAFNSRDVESVLTPNALELARAGGLRVNQPDLPGVFTYLPHIAQRPEVLIPKYNVSQGRTGVKFVIGIPSIKRPVDVYVYNTVGSLLDAMTESEKQQTLILVCIAEPWNDQYAQEVLSTFKKRFPIEISQGILEVFSPKPEFYPNLARLKLTLGDAKERVRWRSKQNLDYAFLMLHAWTRGEYYIQLEDDLSAQKGFITSMSNTINKQYGEWFLLQFSTLGFIGRLFKCSDVPKIMEFLLMFYNQKPCDWLLDDYLRVQSCGHGENWKKCILKIQKIARPIEPSLFQHEGLHSSLQGTVNKLKDKSYGINQTSIHRNPSIENIISTIKQYSKYDIFSAYMGQDVFWGANPKAGDLVDFLFHPPIPISRYRYEMFAIVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W5D1</accession>
    <name>A0ABM1W5D1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase-like protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101853526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829874.1">
        <property type="nucleotide sequence ID" value="XM_035973981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853526"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF101">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035829874.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27884" checksum="D8602E6FF330953F" modified="2025-10-08" version="1">MSTSNETIEVARKHLAVAYKNGGHPEKTATFYSDWSKDDGYDQHLNPDLYRGPKIAAQAVADFFPSSKPADIRILDVAAGTGFVAEHFYYFKKAFFHLQLRDLGFKHIDALDPSEGMLEKARQKRLYDHFICTYLDSNKKLPILEDTYDCAVTSGGMGEGHIPYNSLDQLIRVVKPGGLVCIVMREEYLNHSQYKDLLEPHMSRLEKEGYWQLVSRTVEEEYCFDLSGLVYNFKVLPRQIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A1L024</accession>
    <name>A1L024_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 9">Beta-catenin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100533383</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2006" name="Cell" volume="127" first="1453" last="1467">
            <title>Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Edwards J.R."/>
                <person name="Puthanveettil S.V."/>
                <person name="Kohn A.B."/>
                <person name="Ha T."/>
                <person name="Heyland A."/>
                <person name="Knudsen B."/>
                <person name="Sahni A."/>
                <person name="Yu F."/>
                <person name="Liu L."/>
                <person name="Jezzini S."/>
                <person name="Lovell P."/>
                <person name="Iannucculli W."/>
                <person name="Chen M."/>
                <person name="Nguyen T."/>
                <person name="Sheng H."/>
                <person name="Shaw R."/>
                <person name="Kalachikov S."/>
                <person name="Panchin Y.V."/>
                <person name="Farmerie W."/>
                <person name="Russo J.J."/>
                <person name="Ju J."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="17190607"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.09.052"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="AY952205">
        <property type="protein sequence ID" value="AAY29569.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191600.1">
        <property type="nucleotide sequence ID" value="NM_001204671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1L024"/>
    <dbReference type="GeneID" id="100533383"/>
    <dbReference type="OrthoDB" id="195736at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000015">
        <property type="entry name" value="Catenin beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013284">
        <property type="entry name" value="Beta-catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45976">
        <property type="entry name" value="ARMADILLO SEGMENT POLARITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01869">
        <property type="entry name" value="BCATNINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="297"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="340"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="463"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="510"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="618"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="755"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAY29569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="NP_001191600.1"/>
        </source>
    </evidence>
    <sequence length="819" mass="89962" checksum="E54B533012FA1F02" modified="2007-02-06" version="1">MSSYQMNANSGPNRAMGTVGEPSYMDLSNMPVDNKQQQTMMWQQNQYMSDSGIHSGQTTQAPSISSKSHGEEVDEGEMDPSKMMFDWGLGADSYNQEQVDEINQQLNQTRSQRVRAAMFPETMPEGVQIPSTQIQADQPTAVQRLSEPSQMLKHAVVNLINYQDDADLATRAIPELIKLLNDEDQVVVYQAAMMVHQLSKKEASRHAIMNSPQMITALIRAMANTEDIETTRCAAGTLHNLSHHRQGLLAIFKSGGIPALVKLLSSPLESVLFYAITTLHNLLLHQEGSKMAVRMAGGLQKMVSLLQRNNNVKFLAITTDCLQILAYGNQESKLIILASGGPGELVRIMKSYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALAMHLGHQSQRLVQNCLWSLRNLSDAATKMDQLDHLLQMLVQLLSSNDINVVTCAAGILSNLTCNNHRNKVMVCQVNGIEALVRTIMQAGDREDITEPAVCALRHLTSRHPEAEMAQNAVRLHYGLPVLVKLLHPPSRWPLIKAVVGLIRNLALCPANHAPLREHGAMPRIVQLLIRAHQDTQRRASISSNGPPLTGYVDGVRMEEIVEGTVGALHILAREAHNRAVIRGLNCIPLFVQLLYSPIENIQRVAAGVLCELAADKEGAEMIEQEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSMELTSSLYRGDPNWADPPVFEEMTMPLEDSRDPMYNAQGSQGSMYGGAHSDMGRGPTGYEQVPIDSMQGLDIGSQHGSGYGPMDNLPDLASPGDINFDNIDPALGPPGGDNPNQWYDTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0WLR9</accession>
    <name>G0WLR9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 15">Neurexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100856796</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2011" name="Neuron" volume="70" first="468" last="481">
            <title>Neurexin-neuroligin transsynaptic interaction mediates learning-related synaptic remodeling and long-term facilitation in aplysia.</title>
            <authorList>
                <person name="Choi Y.B."/>
                <person name="Li H.L."/>
                <person name="Kassabov S.R."/>
                <person name="Jin I."/>
                <person name="Puthanveettil S.V."/>
                <person name="Karl K.A."/>
                <person name="Lu Y."/>
                <person name="Kim J.H."/>
                <person name="Bailey C.H."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="21555073"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2011.03.020"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HM461999">
        <property type="protein sequence ID" value="ADM64537.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001240692.1">
        <property type="nucleotide sequence ID" value="NM_001253763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100856796"/>
    <dbReference type="OrthoDB" id="6275838at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000029">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF89">
        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1476"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="35"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="216"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="261"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="460"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="645"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="685"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="884"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="1120"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1292"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1370"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1521"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1376"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1408"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1420"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1444"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1521"/>
            <end position="1530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADM64537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="NP_001240692.1"/>
        </source>
    </evidence>
    <sequence length="1552" mass="170694" checksum="F1D1CEF3A7610EB3" modified="2011-10-19" version="1">MAVELFPFSPRHLQCLTLAVAIFAAILCRLPCAHTLNLDGSPGSYVEYPPWEPCLNGSFSFEFRTSEPLSLLLYLNRGSYSYFEVKLLKGGIRLRMNLGERTMIIRAGQNLNDNKWHSVEVVQDGDLTTLIVDGIEHSKTSSGLLHTYNGLANETFLYLGGLPMEYESKKFNSLALPSVIFEPKFRGSVRNFFYRSCGGEAVRPQPLSSAGLLTTDVDLCERGNPCLNGGRCLTTDNGVLCDCTATEYRGDRCDIQKIPSDATFMGTQYFSYNLSSRGDVMVDQDRVRLDFRTKQANSLLFYTGNSKDYMTVGLMDGAVFLTINLGSGMYQAEIRPSGTRFDDNRWHQLLIQREARELPRDAGVCFVTMELDGMYRKQGSITGKFIRLSSNLLYVAGSPNTETLPGSRVRTNFKGCLRKVRYRADGVLLDLTDLARREHSLMQVTGDVIFDKCQELVESHPVTFTSPESHLTIPTWSKPGIRGSLAFQFRTVEPGGLMMYSNGGRDSKDFFALELLDGHLYLVLDMGSGILKIQASKLPVSDGRPHDVYFEFKGYRGDISVDGQKVPFASGRVSDRFDLHGFFYVGGLGSEINASLLPRELWAVMLGLSYVGCLQDLVLDGSKVDLLAAARLQNKSDVAGYCKQTEPQCVSHPCNHGGKCVEGWNRFSCDCRATGFVGAVCQTAAATLQFDGTQFMKVTMSRESVTQAEDVSLRFRSLHPSGLLFLTTGGNDNRMQLFLQQGTLFLSVNVGSGSKVLSVGHRLNDDRWHTVFIRRRVQTVELAIDSDRPVIDQLPGSTFSLATNYIFVGHKNPPGTEVADLPGRARELGLSSVEAGHMVQDDSGAGTGHSGSDHSGFIGSMQAFIFNNNHFFQMAKSGTGDNIEISARFSSDEYVVRDPVTFKSVDAFAILPTLQAHEEFSVSLQLKTTESDGLILYNGGNENDFFALELFQGFLYYVYNMGEGAQRVKANVQHPINDNKWHEARIFRVEKFTQLLRVDDNTPTVDDLTGTKNNRFDLDGFLYIGGVRKTMYPSLPKLVYSRHGFVGCLGSLNLNGYLPNVLREANPIHESVGDGCRGPMSKCVNDSCANQGRCVQQWTSYKCDCDMTSFTGPMCKDESVSYKFGPGPGLMTFAHLADHEPSTNFDNLAFGFKTFLSDAILLRMDSRAYDDFIQIELADGYVYLVYNMGSFDHPLGDFYHKVNDGQYHVVRFTRAGPNATLQIDADMPQTKHPTGKQAHTFNNQAFVRIGGTKVENGSITQHFEGIISGLVLNGINVFELAKHEDPKVRLEGSVSLNQRPQPGPFRPPQLYTDDEDLDEMQSTQGHTTPRDGVTDDDIIQAGAGSGCQFDNSEDCSAVGSGIEEIITPVVIVKTTTPPPTTTPKPVPKCQGEGCETSSQLRQRPDPSLPSSTLSPSGSGHDYGGDGGGNGDIDYVGGSGEIEPTDNRDGYHGHFDKSTTKPGKTTDDDDDDDGVNLVLILGITGSVLLAVIVLCIVLCKLRGRDEGTYKVDETQNFSALQSKKSQGNGSLASGGESCTGKRGKKKDVKEWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>O77063</accession>
    <name>O77063_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 15">Carboxypeptidase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100533325</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="1996" name="DNA Cell Biol." volume="15" first="937" last="945">
            <title>Molecular cloning of Aplysia neuronal cDNAs that encode carboxypeptidases related to mammalian prohormone processing enzymes.</title>
            <authorList>
                <person name="Fan X."/>
                <person name="Nagle G.T."/>
            </authorList>
            <dbReference type="PubMed" id="8945634"/>
            <dbReference type="DOI" id="10.1089/dna.1996.15.937"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="1999" name="DNA Cell Biol." volume="18" first="121" last="132">
            <title>Cloning and expression of Aplysia carboxypeptidase D, a candidate prohormone-processing enzyme.</title>
            <authorList>
                <person name="Fan X."/>
                <person name="Qian Y."/>
                <person name="Fricker L.D."/>
                <person name="Akalal D.B."/>
                <person name="Nagle G.T."/>
            </authorList>
            <dbReference type="PubMed" id="10073571"/>
            <dbReference type="DOI" id="10.1089/104454999315501"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AF007570">
        <property type="protein sequence ID" value="AAC36548.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="T30916">
        <property type="entry name" value="T30916"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191551.1">
        <property type="nucleotide sequence ID" value="NM_001204622.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M14.016"/>
    <dbReference type="GeneID" id="100533325"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03868">
        <property type="entry name" value="M14_CPD_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000004">
        <property type="entry name" value="Carboxypeptidase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF57">
        <property type="entry name" value="CARBOXYPEPTIDASE D, B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3 13 15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11 15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004159826" evidence="11 15">
        <location>
            <begin position="27"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="34"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="467"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="859"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="1227"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAC36548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="NP_001191551.1"/>
        </source>
    </evidence>
    <sequence length="1446" mass="158940" checksum="B329C37F3950C112" modified="1998-11-01" version="1">MELPEQYLCRRIFYLLLSCFVLVCSTENVIDTSKYHRYDDIVSLFTSLHAQYPDITKLHNIGSSVQERQLLAIQITDNVNISEPGEPMFKYVGNMHGNEAIGREVLIYLTQYLLFKYEEGDERVKKLVDSTNIFIMPSMNPDGFEKAKINDCMGVGGRGNYYNVDLNRNFPDQFGGNKEKVQPETKAIIDWIESNPFVLSANLHGGSVVASYPYDDSKSHRHGTYSAAPDDAMFRLLAHTYANNHLTMSKQERPCSGDFFKDGITNGAQWYDVPGGMEDYNYLHSNCFEITVELSCCKYPPVNRLPIEWDNNRESLLAYLEMVHIGVKGFITDAETGQGIENAVVMVEGIAHNVTSAQFGDFWRLLTPGTYSLRFVADGYEDTVQKDIVVPSGEGVSVNVTLSRKGKAVAMPSATSKGPEEKLETTKEPVVTVPPGEPLDRLMSYLDGLKDFSHHSSTHFKEPSEFVHHNFQEMTKFLQDLADKYPALAKLTSIGQSVQGRDLWVLEITENPGQHMPGKPEFKYIGNMHGNEVVGRELLLLLAQLLCENYGQDDLVTLMLQQTRVHIMPSMNPDGYEKGREGDVSGIRGRANANLVDLNRNFPGLFHNTSVNERQEPETLAVMRWSRSLPFVLSANLHGGSLVANYPYDDFEQETGHGAFSPSPDNAVFKQLAEAYSLAHAKMHSGKPCPEISGEYFPDGITNGAQWYVVSGGMQDWNYGFTNDFEVTLELGCVKYPMENELPKYWQANKDSLLVYMGEVHKGVRGFITDKQTGMGIFNASVMVDGIEHEIFSARDGDFWRLLTPGTYSVSATAPGYDLQTITVRVTSGAAVPVNFTLERSSWSEDHDFDIKENMRGHAYMSPHAIVETLGYLARTNPSVAAYEVLAESSDQENLPMLHLTKELGSPGGGSDGLHRDDRPHVLLVAGINGDAPVGSEVLVRLARHLITGFNRGEPVVTSILSTSHVHILPRVNGHSTAAHPGDCSGVNYTGPRFNDLVESKDPVVADLTRLIALHQFDLILNVDAGGKFIVIPRNVLASSEMSAASALTDDEDVLQMLAHSFAEGMTEVYHGDACPGARHSGIVHGVDMGREAIALADSVYGQYGTLMLSTHVACCKYPAASEIPGVWRVSLQPILNVLSSAMQGIQGKVTNEKGEAITSYSLQLDNRQKREKKSAFFILATTGLHSISVSAKGYVPMTQGVMVTNGAPKPVTVVLTAEAIGGDELTYHSNEALTAALQNLSTSCPHLVSLSDIGKSTMGQTLWMLRLGHGHVTERVPPSVMFIGGLHGDEAVSSEALLMLGTHLCSQYSRNEFVRQMLDSMYVYVVPAVNVDGARVAVEGFCEAGMGHNNSQNVDLDKNFFPGDEYRQVVEQPETRAVKKAMEAAKPSFVVNVRAGNNVVSYMGPADRAVAKAFVNSRDVSDKDSAGCGKQTGECLMPLVDLISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0J9Y5</accession>
    <name>A0ABM0J9Y5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-related modifier 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005088845.1">
        <property type="nucleotide sequence ID" value="XM_005088788.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850446"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005088845.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11411" checksum="334A2E951D93FEC3" modified="2025-10-08" version="1">MPLPLIIEFSGGAELLCGNVKKHNVELPEQKDKWQVRTLLPWIRDNLVQERPELFMQGDTVRPGILVLINEADWELMGELDYELEENDRIVFISTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA49</accession>
    <name>A0ABM0JA49_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein KIAA0825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005088941.2">
        <property type="nucleotide sequence ID" value="XM_005088884.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850608"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027993">
        <property type="entry name" value="DUF4495"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960:SF1">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14906">
        <property type="entry name" value="DUF4495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="934"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005088941.2"/>
        </source>
    </evidence>
    <sequence length="1404" mass="157060" checksum="9E8C3FC396B45F4A" modified="2025-10-08" version="1">MSHSDNNNPTAGYIPPFASLFQGDMVPSPSALQSLIADIDGQLDQNTRELDKCLQSILTSANNLPGSRTFSIPRDALGYVCSSHTLEKDTCYDPESEEAVAIIVALIDSLEKNPGSEESILQEILALASEEGLTLPLKNSLAGISQSSSSLNVQLDSMDQLIEGKWSKLSHAVQKHLVSELLKLPQLSKNRRTAWAIIERRSELVGGLRSLASDDEAWVMYRNVRGQQLEQLFNSLLPDNDSENVNYKEFCCNCGTVADRLIDMIEEDFTVLCTGVFKKIGGVYRILHDLYLEKYSDEMSLLVEEIADDIRDFNKKVVKASKSDHGLSKTDTGSGKGHSKSGPRGSLGATDSWASKTPLNSQSLDTMFLASSFRTDKDKSGTPRLQKQSSMAFPKDCISSLRHIAMSLMKLEDFLDGLTKMTSWDVTGLPNRKSKKKSSLRGVLKTSASPELKRHSLNLGSSFSSSDTPYDLAHPTGQTTPPFEHTPAPKVIERSRSEDKVKWDWRLIFKKIASGLASAVEAKIDHTMSTTLTHETSTWHGKHLLDTVTLDFAQYGEGMDHPRVVSKDTHDFIQAIDELLPLARAGIEGCLIPVRTAFIDSLGIAVKNFHLHCVTLSKDVPHKATVRSVLVIVSNAVYVKNYLLHVETILSTEDNGKKFMTSLLKQYTDLIDGLGKHILQLHNQMLATSVFSDADSGNWAEIKEFQEDERCSFTVQMWNFYLQGIQQDMWQTLPPRLAQNFFSSVLQDSLLLMMQRYARVRPSFRRFKQMRYDITSILLCSIEHLLKACSSISQYLDPGHNQLPHYSIHNQCSNLLAVMAVVTSPIDTLYRVFKRGYSRRTESQDSGSSSQYGNNTQWLHWMWPSLIHSGTKHYDDMQTTSALYLHLRIFLGQPQMDWGGLTQALFMKDYTLSILLLTRACQQEESRASLLAKTLKSKSSSDNSNSSNAPVTSKLIPQLSNQSSTDSNSPMDPSPSFLQTGIVLNDNDQPTDIQMVVDALVHILGQVHYFPDALAKCIIPVIDRCTSWEMFNIKNPLVTPEMKVPEWVTSVFKILEPFSDRVIEPMLRYLNRVKTSETFIRPVISYVADLPCGCPPGYSLRDHSKPPGLKDVLSHCLELLITEIEKCVIVLPASVCTLFSMIETNCRDLGIKTSHRCVALQVITWSIWTSLQQFSANVDGLGDLMSSDTRKQIMTVADSLFHVLVYGKGPNTPKFALKFIKSHKDWLTEKINSIASYISDEFHSLPNTDFTEAATNIFTDHVYSLLASSIMDSPNGFKYLDTVSRLVVNNSHWLLEQLDVQPPVPLAATSQRPSSAFKMDISEPVPSDDFNPIKAMMSIGDSPFNQMAIQEFPFDWMAILTSDLGLSQPAFRSLLMNRHEMQEGATLEEAEKKPVDVLRAVYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JB94</accession>
    <name>A0ABM0JB94_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101857844 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101857844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089697.2">
        <property type="nucleotide sequence ID" value="XM_005089640.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857844"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="4">
        <location>
            <begin position="347"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005089697.2"/>
        </source>
    </evidence>
    <sequence length="504" mass="57967" checksum="D34B197BC721D821" modified="2025-10-08" version="1">MVTCSLFENWHNFVARNTAAFALCHRRFSLILNSQSKPFSAVTKVTVRRMDGVEKDAIGSWALPLAMDIDMDTEDKIQSTNMDDFEDEQCEERDREAVVKKTPIRSYADLRRKITENHSTESPSSDLTPEKTSVDDPQRHSEYDLREKLNRKGSRDQERRDVTMRGQRYRRKEFHSNVARGSRVTSPLRSPHDNVKYNILDMDNSNSHRFTRNRIGAPQQDFKRPYHSRDSPPPRHRNSRFQRNKATVRESNSGESVQSTPSSHTVFSDESESDGTPVLSRISPKRLRMSGSRRRLQLPAEDESEQDADERDSESENASSLVREDEEAVSEERSPGSSHRIDLSPIDEARLARKEKDVQYGKNTDAYKLYTEVVPKASRSRNKKYHPRTPEKRIKCSRRSWDSQIKIWKRRLHTWAEAHRTSHNAVEEEGSSHSLASSAGDDRVPQAQKATEAADDDLVPQAREPIEAAEDDYLDLDEDDFLDSANLNLDVTEIEEKIKINDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBG5</accession>
    <name>A0ABM0JBG5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G1/S-specific cyclin-E1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089821.1">
        <property type="nucleotide sequence ID" value="XM_005089764.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845141"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20519">
        <property type="entry name" value="CYCLIN_CCNE_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="167"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="261"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089821.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50530" checksum="F862DD43A19936A7" modified="2025-10-08" version="1">MSRKGQRQALRSRSVENESDQEIERQASKRRKTIDASEADRQQYRIQNQWIPIGDTVSLPSSALVRCTDSQSDVTDEVDGDMVASTSEPVANQSFEKFRSLDFQLRFQNVFATPHTAIQSPLPAFNWANSGDVWKNMLLKEEKFRRDAGMFRNHPELQPRMRSILLDWLSEVCEVYRLHKETFTLAVDYLDRYLSVVDNVPKTQLQLLGISSLFIAAKLEEIYPPKLSEFAYVTDSACTEADIVRQEMIILKALKWDLSPMTTNAWLGVYLQVANMDHITDPELGFVFPQFSTHAFVQISRLCDLALMDVGSFKFYRNVIAASALYHHTNEKLVMEVSGLNWADLYPCVKWMNPFAKAILEVGQSPIKYFPHINAEDCHNIQTHNVDMVLLDRALAHQVTMEEREKLYPSSLDLSAQLVGLLTPPSNKKTQPRTQTSSGCGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEW5</accession>
    <name>A0ABM0JEW5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Cell division cycle protein 20 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101864047</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092134.1">
        <property type="nucleotide sequence ID" value="XM_005092077.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005092135.1">
        <property type="nucleotide sequence ID" value="XM_005092078.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864047"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 11 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="196"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005092134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005092135.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="57072" checksum="DD97CAD18F014BDD" modified="2025-10-08" version="1">MAHFNLENDINSALRMDVPSARPPLMRVQRFEQTGGSSSFNTSTTATKTPNKSLNKSLSSGALAKTPSAAKTPNSAGRKKTPGAKPPKTPTAGDRFIPNRSVNNFDLAHYKICTQARPSEDEQSMMSPSQQEYKAVMSENLNGDLMDKKILSFKEKPPQAPEGYQNDLRVLYTTGKMGSTAKKTTRYIPQVPERILDAPDILDDYYLSLIDWSALNVLAVALGTSVYLWDATTGGINLLLEMDSSGGDYISCVNWTSDGNHLAVGLSSGAVELWDPVQKKRLRTMAGHAARVGALSWNSYLLTSGSRTGSIHHHDVRVAEHHVGTLQGHTQEVCGLRWSPNGNFLASGGNDNLLNIWRANSGSLMTGTEPLYTFNEHQAAVKALAWCPWQPNVLASGGGTADRHIRLWNCNNGGSLSSVDTKSQVCALLWSAEHKELISGHGFSQNQLTLWKYPAMTKIAELTGHTARVLHMCSSPDGATVVSAGADETLRLWKCFAIDEQAKKTKSKTASKDDRSSLRFHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEY2</accession>
    <name>A0ABM0JEY2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein MEX3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101854000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092167.2">
        <property type="nucleotide sequence ID" value="XM_005092110.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854000"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22424">
        <property type="entry name" value="KH-I_MEX3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16518">
        <property type="entry name" value="RING-HC_MEX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047226">
        <property type="entry name" value="KH-I_MEX3_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047227">
        <property type="entry name" value="MEX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23285:SF7">
        <property type="entry name" value="LD09246P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23285">
        <property type="entry name" value="RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="585"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="543"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005092167.2"/>
        </source>
    </evidence>
    <sequence length="639" mass="68409" checksum="4F5A02D15F62F9AF" modified="2025-10-08" version="1">MPEPISDMNRNQEVGYFGDFYGNEEPLDINVRNLENLSLMDNFSSVSTLAGAENNENLAYFQDNFDAACAAPFLDDPKEGNISKTVRVPSSEHVAEIVGRQGCKIKDLRARTNTYIKTPMRTQSPVFVVTGKEEAVLHVMEEINSAAEHFTHIRASRNHHKAGGGLESAKPVSREGDIVQYVTVPYRVVGLVVGLKGQTIKAIQQDTDTFIVTPNRDKAPIFEIRGQPENVERAKMMILRHIETRTRHCRLQDTTNLPSNWNDEQRFTNGNDYPYYHGDVSSQMGPGSNSGLPSVSNNFNGNSGMLSGTPMPSQQGPGFSNTFSASSPTSSSSYNSWRGFNSLLDQHPQQAAGHMATWSNATSDYPSALGSSSVVSNGSNNPLSSAVRSNNNFQYSISTGSISSPSNSTVSVSPPNDFLNDGTFTNHQLPSPYGGAAPMNNPFLKRMSEPSAADSPFSSFPLLTTAPSTSTKGSLVLGNLFQPNNNVTSALGIGLMSSSNNVLSNSALNGFQSPGSDEPNATNLPALGGGVSFRRGMTSTAPGEVSVFPGPMGVEMNRFPSGESSPTSKMSDTSGSQGSPVPRVCKVCEEAEVVAALVPCGHNLFCMECAEGIVNKASEDDRTCPVCKDPAADVLRIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFD4</accession>
    <name>A0ABM0JFD4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC101851392</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101851392</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092421.1">
        <property type="nucleotide sequence ID" value="XM_005092364.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005092422.1">
        <property type="nucleotide sequence ID" value="XM_005092365.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851392"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="704"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005092421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092422.1"/>
        </source>
    </evidence>
    <sequence length="1061" mass="119658" checksum="CFF10C11FF923D56" modified="2025-10-08" version="1">MGKLQEEEKSDVKREVVSASANLEVISQESFVKRLEGMSSACANCQRERTRTQRSKQGRKGKGARRKQQHSKASTPIVIHLKDTLRSPGKQYHQSSLDRDSDGFGRSSEEEQQQFSSRSATGVRNSIYHPQKLRRHGSDYQRFSSFYRDVDSIPEFVPNSYHHFHQACPQFHHHHHMSQSLTSFGPSYHKSPFVQSHLMIKDAKDKSRKNLTALISVIEKAHRKEPKDLELNLANNSADTKTFNILNNISVTSHSEHGTKRLNMAECENVELICNDLSTTAEKVVESTDESDTSDKASVVSSSDTLSDDIGDLPLLDEVRGCEFTRDELEQLAEYTSGVPLIKYDCPPSHCPECVNTWCLYRCYQYDDSASAEDAGFLSAPPGSEPRHQPHGKPQQHQFRGQLRSHGQLRSHGQYRPNQKAAAAMAAAFPRVSLSSDSDVSSDVEDSCSTRSLPSNSPPPPSSSPPPATMTSSSSPPPPPSSFFSVPSQRAATTSVKSSAGSSSLHVSYTQERPSHRRARHVAPRCLNMDSTQEDQGGNQKPKHQPRPKRATASWKGARQLWDIDVSQASRRAHLQGSDHITDSVYMDLTGLDVTISVIYHNEPPQFPSPHHHHHHHHHPASSTWPYPVHSLYQAVYSPTLPSPQESFSFPSRYSYPLFHPLKSDFVPLHEMKKYEINTQPSRPWISAGNPDKDVPAAVFTVMCYNVLCDKLCTKSMYAYCPTWALNWEYRKKGIMNDIVRTSGDIITLQEVETEQYFNMFLPDLAQHGYDGIFLPKSRVRTMNSEKEKKTVDGCAIFFKKHKFEKVNEHYIEFSQLATKEGASNTDTDMINRVSTKDNIAIVAVLRTKPGVYENSPVPAPKGLTQMLMVSTAHIHWDPQLPDVKLVQTMMLIEELQKYVKEASMQFRPNAPPPSVDAGDLCNSMPLILCGDFNSLPDSGVYEYLSRGRLNASHKDFEGQNYQVFMKDRKDNGIISHNFKLKSAYKDYIPFTNYTYDFKGIIDYVFYSDQHLRLHGLMGLQDEEWFKANKIVGCPHPCVPSDHFPLFAEFSLPATSAQHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG61</accession>
    <name>A0ABM0JG61_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101851712</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101851712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092939.2">
        <property type="nucleotide sequence ID" value="XM_005092882.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824258.1">
        <property type="nucleotide sequence ID" value="XM_035968365.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851712"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021078" evidence="1">
        <location>
            <begin position="27"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092939.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824258.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28748" checksum="7FD97DE322B23E54" modified="2025-10-08" version="1">MASTSSWITVVPSLLLLLISWERVHGEETTRPVSRQRVGEYSFGKCVVQGLYPQDLDSFNSVEMTREHALGSRWTERCRTCKCDSFGAWCQGPTCPVPYDFSQEKWCLQWSEDGCCCEQLGCSVDDEEYPLHQEFPYGDGNPCLTCNCMIGQSKDHCLRQKCGTSDIICEDRSVTYDDDCCPFFTCPHGAFCDVIPDPYPESPRHELLDWYRNIDPLPVGMTQHFHIDSWNTYVCQCMRGGTANCTMQSFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHX7</accession>
    <name>A0ABM0JHX7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Protein NCBP2AS2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4 5" type="primary">LOC101859693</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094026.1">
        <property type="nucleotide sequence ID" value="XM_005093969.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094027.1">
        <property type="nucleotide sequence ID" value="XM_005093970.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094029.1">
        <property type="nucleotide sequence ID" value="XM_005093972.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094030.1">
        <property type="nucleotide sequence ID" value="XM_005093973.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859693"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042407">
        <property type="entry name" value="NCBP2-AS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41161">
        <property type="entry name" value="PROTEIN NCBP2AS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41161:SF1">
        <property type="entry name" value="PROTEIN NCBP2AS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005094026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094030.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14437" checksum="8ABBBB8172524674" modified="2025-10-08" version="1">MPLRQLLRMLMNNEEIIRKLSDSYPIRRAAQLTAYFFHKGKEIGEDNLEKLKESDMVNRLKQEGQHSVDKGKQQFDQSVNKTNSFLIKFFDAFSDEWKKAEKEIEEKRVKEIQEKTKRKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJL2</accession>
    <name>A0ABM0JJL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101860157 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095172.1">
        <property type="nucleotide sequence ID" value="XM_005095115.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860157"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="228"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="333"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="546"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005095172.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="65090" checksum="6B6141029B482F79" modified="2025-10-08" version="1">MRHRATDKTIIKSRSNVRRCESYTPGRRCADMKKKEAPHSLRQRHGAALTLTPTLTLTAANVINVMVVCWASASLLTTVGADECGTRFVDPASSAVRAQAVVMGTVMEWNPSARHERTRSANVSVEKVYKGEGIVNNARAGDDRMIMVSQFGREDKDSCVASDTEMTSEKKHIFFLRQSHHRGMLQMSALPLPMESRAERRVRRSLCDTCVRPPRIKKLVCRDCAQPPKMKDIKPKKVTMGRKVRLRCVAKSQPPPSFSWSKNGIPVTTGNGGITIRTTATSSSLLILKTMSAHAGEYKCIAKNDLGTSEKVAVLELSRRRRKPKYTVQTAPDRVACAGGNLCLNGGTCFHSPSLNLRSCVCPPHYDGVRCELLDESKVPSVHIGPTSAAEAGNSRRSGQPRQGERPRQRQGGVTSTETETEASRQQTARNSAVNNNNVVRENQTSRRRLDSNVSGSAGSERNNRREGSDTESNTVRSTLPAKSTPGSQLSNAPTPTTAAGAPSERSSGGHIDSTRRQKLKTRPSNRKSSVSYNELQHRLRNTHIKIIHCREKRYCHNGGRCRYIPKQKFKFCQCRAGFVGKRCERSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKT5</accession>
    <name>A0ABM0JKT5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101849918</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096053.1">
        <property type="nucleotide sequence ID" value="XM_005095996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849918"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005096053.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24089" checksum="1F04A44C1D522B6D" modified="2025-10-08" version="1">MTDPTRIFNADESGFSFDPKHRKVIACKGAKNVYNITSNTKTRVTVLATVNAADFYLPPLLIYPYKRVPGKNLLNGFPDALVQVSENGWITAAIFFAWLRDTFIPETMHIKKPLLLLVDGHICHTSLYETSEICEDNGIILYCLLAHSSHLMQSLDQTFYGSVKSAWSDASRRPIAETGDAVGLDTSAKVFQHFWQTCATTENAESSYRAAGIFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKX2</accession>
    <name>A0ABM0JKX2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aerolysin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101846954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aerolysin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096128.1">
        <property type="nucleotide sequence ID" value="XM_005096071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846954"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20219">
        <property type="entry name" value="PFM_physalysin-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.412.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055267">
        <property type="entry name" value="Aerolysin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053280">
        <property type="entry name" value="Aerolysin-like_pore-former"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34007">
        <property type="entry name" value="AEROLYSIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34007:SF1">
        <property type="entry name" value="AEROLYSIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01117">
        <property type="entry name" value="Aerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00999">
        <property type="entry name" value="Aerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045391841" evidence="4">
        <location>
            <begin position="23"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Aerolysin-like C-terminal" evidence="5">
        <location>
            <begin position="188"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005096128.1"/>
        </source>
    </evidence>
    <sequence length="588" mass="65942" checksum="FBE9F07EABC31DE5" modified="2025-10-08" version="1">MVVIATSCACLMFLLYASSVHGCGRSGSSDSDSEGVLKCSGTSSEYVKGLERSSRGNPDSILLIEEAVCSNAPSPYRRDHTQIFFADWEHSFDRNYNWNTCPDGYFVQGFYWTGGERLGNIRDGRCMKPASHPYHYGHCYDKDVSVSFNYRGVSECRDDYFVTGLYRGSCDQLYCIEKMRCCNMAPRPDTINSLSQAKIRVMDNTMSDIATLAHYLGYGWCASCRAPYVGEDFRRQGDTWQADTTEPCSGALSHHRLSMNYGHWKFSIKNMTFGTPVLQSLQPETVDTGVVNNELPYDVTRVITRSADVIRSVTHTATSEWRRSHELGLTFGYSSVGFSSSAEYRFTYGTSTTTSDSTGRTQAGSFTVKESLTVPAYSAANFTIIISQTRRTVSYTATILIHFSTELGGFMRWGRGPDGRLTNCHYQHKGSERRPTVHYRFGNARVPFYEALKEESDSLQRPWLWADMKQRYTYGQNVINRLTREGRYEFTLTGKFDDVAGNDVQIQWGEPYPMLGRHKRSAHAHATGSARVSDKAPHKVVIHDAEVEVKKVVATEKPGDPPSEFPPPPVVALDPDSVVDPPKEISSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JL24</accession>
    <name>A0ABM0JL24_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 28 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096213.2">
        <property type="nucleotide sequence ID" value="XM_005096156.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845913"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="8">
        <location>
            <begin position="243"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="9">
        <location>
            <begin position="426"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005096213.2"/>
        </source>
    </evidence>
    <sequence length="664" mass="74281" checksum="CD88B373661BF1D7" modified="2025-10-08" version="1">MADGATNDEKGDNYRTNAIMLQNNHTGDGNDGANHAMNNGDKTTKLALDFEPSGAVQTAEPLSEKAKLEPVVEIETENLLKDEIDDNEYWTDEDEEEDEEETKKEGILSKFVISVQQIIIRTYYTLMKVTKGHLIKVVFLILYAVYFVRAMIYEFGSEASHRLLGFTILGVVIATRNLIMQAYNRLFRACVGSSSFGPTGQRRMDKIRLALRWFMYFALAGVVIYTVVDEGIDEPKNLRSLPGLVVMLLIPLFFSTHPSKINWHTIYWSVGLQFLLALSVLKWDTGRDVVLWIQDRLDEFFANSEEGSVLLFGQSYRDHYMIFGALPIVFFANAVITALYYLGALQFVVRVMGNALNFCLDTSPVESMAVTGGIFIEGITSLLALRPYLKKCSKSQLFVVITSVFSSLGGAYLAILSSLGVSLEFLIPAMVVSAPATFAVCKLMIPETKWKKEKDKNRQLVVDESEMSQYTGLMDAAQAGATNMLALVGNVAVVGFAFFTAISWINHTLSWIGDRVGIRKLTIELISSYVLYPVALLMGIDPSDCRNVGMLLGYRIGINNIIAFFKLAEMKMNRAQYDQYMLATNFTGPVSETRDDVILDLWNVTLNNGFISDRSEAIVTYSLCGFSRFVDTFPNCVIYINQCIQLIMIPPPSPLLLLLILFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLI4</accession>
    <name>A0ABM0JLI4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein Xfin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101857182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096525.1">
        <property type="nucleotide sequence ID" value="XM_005096468.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857182"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="635"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="749"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005096525.1"/>
        </source>
    </evidence>
    <sequence length="1076" mass="119829" checksum="62A30483EC6639BE" modified="2025-10-08" version="1">MNESENDSNPTSDTLAFIDLNGTPVIADGDTEEDYFICRKCNKVFKNLPDYLEHKIKDENFRITQTRSKADKRFALPNLVQKRKRQVRKRKAQVVSVRKDANGVDAAVEQNTDTDNEKKEENLDLLKQEKEKDSGPKHITGNVERAATAYSCSVCQKTFRREATLRWHIKYEHNQKEENSDESDAEESKIKEEVLSSRDEDYKAEKEIEEEDDHHLNDDAEGPGRKPREIHVVIEKPGTAEPVKQRVSKPSTGAAETERPYSCDICFRSFKELTVLKAHAVVHSDERKYICTFENCPYGFKTKGCLVRHMRRHTGERPYECERCGRAFAESGALTRHMKARRNCSEAPDSQFPRYRKSWNYHPNIPAVIDPSQRDAHRGPSTLPVPNKPELPVTDLHFILSHGAEEIVEGEDTLTGVTVKLDSSAAGAPSVEEWTVKAEPGSLAQVEVGAETKMVNSVVKPLGSLVSTGAGQDSEMLELQSIAQAEVLKPTQCQVCKKDFAAEEGLEIHLRSHLADKPSHCGLCHFLSNDREELRQHILSMHYDSLNNIEASVLSSEDPAQNKGQNSNKKVVLREALIAVKQLFSLKKNRASPTETTAPEPSTAGSVKCMVCDKSFRGSTYLRQHMRMHTGDRPYQCPHSDCHQSFISRDILKKHMFVHTEQRDFKCGECGKMFKRLAHVQQHLRVHYQDRSFRCSVCDKLFKSQNSLKVHMRTHSGINPYRCHVCGRHFRERGSLQRHQRLHTGEKPYVCPRCNRGFAEQGTLSRHLKAKIPCSADREQSSGTQGMEEGTVLAQFSTVVADTQHYILPQLDDDQSLILPSAPGAEQEELTGEYVVENIEVITEEADSSVRHSTEEAILATTVDGQRVEGAVVDGQMVSTGQVVDGQMVSTEQMVDGQIVTTGQVVDGQMVNTGQVVDGQMVGAEAVEGQMVDSAVVEALANEGDEQTETLQIFDASTGESVIIVAERSIVDLVREQQLTFDSVQGESSLQRIKDLIIAAGEGRVTASTQSELDVAVQEPLWQDQQIDIGTADTVIVSGIGAETTETSQLGTEQVTVLDTVSDLGPELMAERGSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLR1</accession>
    <name>A0ABM0JLR1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101863808</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="RefSeq" id="XP_005096640.1">
        <property type="nucleotide sequence ID" value="XM_005096583.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863808"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005096640.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52227" checksum="B717C8DFC47D5B19" modified="2025-10-08" version="1">MSTSTLESDLRQRSSGQTQTTKDQDAEEEKRQAAAASASDSDDDDLPVKPSVPTTQGSDKTTDALDSALKDLTPRWRNWVIRGIFTWVMILSFAVLIYLGPLALVLVTFALQIKCFHEIITIGYIVYRSYDLPWFRTLSWYFLFASNFFFFGESMIGYFGVLLARTDFLRPFVTYHRFVSFSLYTAGLVGFVCSLVKKHYLKQFTLFGWTHVTLLLVVVQSHFIVQNVLEGLIWLLVPVSMIICNDIMAYIFGFFFGRTPLIKLSPKKTWEGFIGGAFSTIIFGIMLSYCLLQYDYFVCPVSYNEATEGLSMDCERSHVFVISEYSLPEAVQTFRKMFGFQKATVSLYPFILHSISMSIFASVIGPFGGFFASGFKRAFKIKDFGDTIPGHGGIMDRFDCQFLMATFVHVYYSSFVKVANPQNIVQSVLMLRPDQQVQVFTMLRDKLILRGLIGNGTTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLX1</accession>
    <name>A0ABM0JLX1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101849838</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101849838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005096750.2">
        <property type="nucleotide sequence ID" value="XM_005096693.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849838"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045075086" evidence="7">
        <location>
            <begin position="19"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="870"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="391"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="908"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="944"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1086"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="961"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005096750.2"/>
        </source>
    </evidence>
    <sequence length="1105" mass="122589" checksum="26739B30C8B653F0" modified="2025-10-08" version="1">MWLLPLILSSLTLAVTSGDFIKTCDEQQHTSVSVTPTGSVSLCVKTDYKPHVFVKAGIHWFRKGEEGNGFKIDWKKDDDSNFNITIVALNLTAGRTHDLKFYPFDGTRDRKNLTVTVHVVRATPQEPAETIPRTSAPPKSRVNQANSPKEQKEDSEDREKGGARQQGEDDGDHNETHESGCPDGSIVLGEFCAVFHKKRSSMADAHRQCQSKRMSLSADGLSSSDFDMLKKSVQVKAVWTGRRKWSKCETHKLNNATTSKYKSCGRNRAFFCFSSRKGKPKLCSWKKEEKEPKTVFFDPSSSDYIRFQLCVVAFPDLIKTIKLNEKQVIAKLSYNEHRVTIQPDPRGLHQHMVEIELRDKSYRAEMSVEVEVISSEYNRATFPVELRPVGCPKSLSAIGSSFNYVTLSWKPVPEFDMNQSYYVFYSKLSEGTWHRSHVRESKPMGGLVSWNVTGLIQDSRYLFKVVALSNGSRVDDVIKNYCSKEVSEATGFPLTTTALNITTPPTTTATTTSTTLRSTRRYFRSTTTSKHTETESTVTSARCFPPSTVRGQCPLGWLTTRDNSCVAFLMTPSFLEGYKDCSKKGGKLFSIGEKERPCVADFLNNTRYVWYGVDQSWCKLQDLSSGRWDWKTCQTQHHYPCEVSIPLPQTETVTFERIDRGNNSPVDICSDSPLQILLQCSTTFNPKPKFTILVNNQVYARSRPEHVIGSGNNTYVYSYDFVPEAGGSYNITCVAQGDNTAPVESDQLTILVREPPQTEPEITIISIGPPGNVLKNPEVVSKSTATNVTCLVDGGYPPVTSQDILLTCGNISGSEQITLPPVDSTDGEIACSCSASHITGCYSRSAHTRFNVSALPLSPEASTDISDVTVVASASVAVAVLVVVVIVVVIVLVVRRRRRHSDTAMEMEPMNDPRRVTGQPTETCKSRGRHSDRLFEDDLYVYPRDTAVTTEPEDDPRRVTGQPTETGKSTDGNPYNDAYSDDTPTSDIHSPILVTKTMAEIITPEAPTDPSPYNNVLASAPRSRTGQDGQSRITNPTGQYDVFPGPDSVAFVSDPYTSMRPENEYSQADEVDASYLSTQASCTGPDGYVKMEKIKNQGGNPYEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMT8</accession>
    <name>A0ABM0JMT8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101859402</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005097372.1">
        <property type="nucleotide sequence ID" value="XM_005097315.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859402"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="215"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="294"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005097372.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43451" checksum="3F81C7A5228CEE6E" modified="2025-10-08" version="1">MSMRRVVCGISGGVDSAVSALLLKKKGFDVVGLFMKNWDIRDERGKCSVDEDREDAEFVCRTVGVPLYEVDFVKQYWNEVFSDLVKDYENGVTPNPDILCNRHIKFNHFVHHAETKLGADAIATGHYARTSAGYDLDRIDPDVGVSLLCAKDEEKDQTFFLSQIPQWALQKSIFPLGDLLKHQVKEIATEAGMERIARKKESMGICFIGSRNFHSFIEEYIEPKEGNFLDVETGAVVGTHKGSHYWTLGQRCHLPGFRAAYFVCEIRPDTQDILVAPGTGHPALFTDSFLSGPGHWIQGPPNAANPDSAFHAQFRFQHRHRLIACSGVGNDAGGYSISLERPMRAVTPGQYAVFYRDNTCLGSARIVQLGQTLFDRNVKDTVVFPKDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN50</accession>
    <name>A0ABM0JN50_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="4">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101845167</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005097581.1">
        <property type="nucleotide sequence ID" value="XM_005097524.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845167"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="15">
        <location>
            <begin position="303"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005097581.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="65937" checksum="CE3A7A2953707172" modified="2025-10-08" version="1">MPTISVKRDELFKALERTYTDEEFDELCFEYGLELDEVTSEKEQMEREKGVGKAVGASEVVEYKIDIPANRYDLLCVEGVSRGLRVFLQKDPTPRYKAVPPKTGAPQRLVIQSSTAQVRPHCVAAVLRNIKFTQERYESFIDLQDKLHQNICRRRALVAIGTHDLDTIEGPFSYEALPPSQIKFKPLGQEQEYTAVELMELYSGDSHLKPYLPIIRDKPVYPVIYDKNRVVLSMPPIINGEHSKITLNTRNVFIEATATDLTKAKIVLDTLVAMFSVYCEVPFEVEMAEVVQPDGTVCKYPELAYRTETVSAAQIRKQVGAEIASADMAKLLTKMCLQSSLAADGDSLSVEIPPTRSDILHQCDIMEDVAIAYGFDKIQKTVPNTNCIAEQFPLNKLSDLLRRDVAACGFTEVLTFALCSKADVADKLGKKIEDAKAVHISNPKTAEFQIARTTLLPGVLKTLYHNKGMPLPLKLFEISDIVYQDPSKDVGSRNERHLCAVNYNRSSEFEVIHGLLDRVMQLLEVPFGGPDGYRLEADTDPTFFPGRCAKIVARDRVIGHLGTLHPDVISNFDLNMPCSALEITIEPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQH3</accession>
    <name>A0ABM0JQH3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-dependent L-type calcium channel subunit beta-1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099165.1">
        <property type="nucleotide sequence ID" value="XM_005099108.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854720"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11863">
        <property type="entry name" value="SH3_CACNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046937">
        <property type="entry name" value="CAB1-4_N_A-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12052">
        <property type="entry name" value="VGCC_beta4Aa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase/L-type calcium channel beta subunit" evidence="3">
        <location>
            <begin position="260"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099165.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="65074" checksum="302DA69E5A0D810A" modified="2025-10-08" version="1">MALAPTQFQEFVETVMPSASQGKGGKRKGKFNKRSDGSFSDSSNSFIRQGSADSNYSQPSSDISLDEEKEALRRETERQALTQLEKAKTKPVAFAVRTNVSYDGSVDDDSPVHGYAVSFGVRDYLHIKEKFNNDWWIGRLVKEGCDVKFIPSPAKLENLKTQSGGGGRQGKLYTSKTNSSSNIDNLLNSSKPSNSRGSTPPTPAGIEETQNGVDSNVGEDSDSLGNSKSSKASITPPAKEKRKPFFKKSESTPPYEVVPSMRPVVLIGPSLKGYEVTDMMQKALFDFLKRRFEGRIIITRVAADISLAKRSLLNNPSKRAIMERTNPRASGLAEVQAEIERIFELARALQLVVLDCDTINHPSQLAKTSLAPIVAYVKISSPKVLQRLIKSRGKSQSRNMNVQLVAADKLAQCAPEMFDVILDENQLEDACEHLAEFLEAYWRATHPPNMMPPSPHAQHRPGGSGMALNRHNTLPAGHMSHSRSGSLERVHSPDSDRHHQAREHHHSSHHHHHHHHHDRQAGGGGGRHHDDDDDYDSDRQRGGGGEHRSGDSDHHHSSHHHHHPHHHASPRGGGGSSSSKYPVRHGSIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR56</accession>
    <name>A0ABM0JR56_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucose transporter type 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101854869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099591.1">
        <property type="nucleotide sequence ID" value="XM_005099534.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854869"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005099591.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="58846" checksum="59DAC6464005AB53" modified="2025-10-08" version="1">MGVEHGGDGKQKTHSPNDTKTSQIDHQSAWTWQFISVLVISYTSMSALTYVVVCLNAPTELIKQFINDTNVKNREEALSKEEVESLFGLLVAVVGIGSIVGCLTAASIADAIGRKFGIFLSSVTGACGTLIMALAETAGSYEMLFVGRVVLGVGLGWNLTIAPSYLAEMCRPSMKAFAVVLNMLFQSFAFIVAQVLGYEEFLGNKEHWSLLIGLPVVVIAVHLLLLMFCPESPRYLLMKKSDYEGAKAALRKIRGIKDVQYDIDLLNEELAESTVDAQISVIGLAKSPVLRKPLIIAIVLGLQQNWCGTNAILFFSTSLFEDAGVSTKDARYATSGTGIIFFICNIVSIAIIPRFGRKTIFTAGTLGMGLASAVIAITMVYKDEVEALKYVNVCVSLLIVASYALGPICVFWTMLSELFPHSARSAGFGVAVTGAFTGYFVHCYVFPEMLNTMHSYTFFVFAVIDVLTAVFVVMYIPETKNKSFAEIASTWTYAPATQTATPDSDAVLYPKEIVIEPASKDVPEIRFSPPHFNSVKRDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSZ8</accession>
    <name>A0ABM0JSZ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AFG3-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101859023</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100797.1">
        <property type="nucleotide sequence ID" value="XM_005100740.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859023"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="312"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="732"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005100797.1"/>
        </source>
    </evidence>
    <sequence length="765" mass="85430" checksum="A9C3C8830CF9A461" modified="2025-10-08" version="1">MAHRFVFPTRQGERILRTLLSKNCICHEARQKLHTTAPLTTKTLFRQLAALNKSAHRFFSDKPQKPDSSSPKSKGDPKSSKSSKEDDEGFEFKFKFEFGGDKGGKKLGGGPPDKQMLAFGALGSAVLLYMLYSSQYREITMKEFFQNFLTSGMVDQVEVVNNKWVRVRFMPGSQVDSSHTIWFTIGSVETFERNLEKAQMEMNVEPNNFITVVYKKESDWGSMVLNSLGWLIPIGIMIWFFRRGPMGKPGAGRGSGPGGMFGFSQTTAKVLEKDIGVKFSDVAGCEEAKLEIMEFVNFLKNPQQYLDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFALARKKAPCILFIDEIDAVGRKRSGRNWGGNSEQENTLNQLLVEMDGFNTQTGVVVLAATNRVDILDQALLRPGRFDRQIFVPLPDIKGRASIFKVHLNNLKTDLQIDDLARKMAALTPGFSGADIANVCNEAALIAARDLNSAIQEKHFEQAIERVVAGLEKKTQVLQPEEKKTVAYHEAGHAVTGWFLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTEEQLLDRMCMMLGGRCSEQIFFNKITTGAQDDLRKVTQTAYSQVVMFGMNEKVGQLSFDMNQQGEMAFSKPYSEATAQLIDEEVRTIVQNAYQRTLDLLNKHKQHVEKVAIRLLEKEKLDKDDMVELLGKRPFAEKSTYEEFVAGTGSFEEDTSLPKGLENWNKEKEEKKSEPDAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JT14</accession>
    <name>A0ABM0JT14_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100831.1">
        <property type="nucleotide sequence ID" value="XM_005100774.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847665"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047162628" evidence="2">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100831.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="41935" checksum="573CA161B15EA6FA" modified="2025-10-08" version="1">MVLRASLCLSLILAVVSQPSFSSLFSEQGVPVTTSEEPCSVTVNMKEHITYSPFVDNQTLPLRNTRNTGVCGSCPTPPSKECRITFTVPDEMDKELFRICYHPEVYRCSQCQRNVTFKESSTNGTSDLETLACSSGNYSGIYTPKIDNECLRPGQNLEIFFYDENFCSHVRLIRMFPQENLLDQPCDSGHLHSHANKGTLYSRQGKGIPVSETFCTKSTNVQKDKKRREFCYSFHYADFQPDGATLHISDQSGNDDREYGYNSPPEIGKEYCVRAQREPYEVKIFLQSDCSSANKSECALHLVEHAFVLAYEIKVLPDPVDQEDDNTGELTAMILCPLAFFLICGILIFCVCRKKKRASNSTYIAAAPSPSQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTD7</accession>
    <name>A0ABM0JTD7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bromodomain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101856190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005101038.1">
        <property type="nucleotide sequence ID" value="XM_005100981.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856190"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021900">
        <property type="entry name" value="DUF3512"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12024">
        <property type="entry name" value="DUF3512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="157"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="476"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005101038.1"/>
        </source>
    </evidence>
    <sequence length="706" mass="77567" checksum="D4FB2E7AC5E9282C" modified="2025-10-08" version="1">MGSKKHKKHKSDNKPSIDQDDGSQEKPLKLVLNLKVGGGSSQESLPDAAGSPQTEERRHKHKKKKKKKSSDKDRERSKYAEESSSLKRPHEDNESGDDDEEEVEKEETSHQYNEMEEDSDGNSSPSRKFREPRMCTIRDNDGAILKQMLNYLLKNLQNKDVNGFFAFPVTDSIAPGYSSIILCPMDFSTMAAKIEAAEYFNVMEFKKDFILMCNNAMTYNRPDTIYYKEAKRLLHLGIKQLSKEKLLYLKKTQSFLTSITLQELGFDESGHIMEPSSVPPVEEAKDKLKDEPSLEVDPSKMDSMVEEEMSPEEILAQAQEAAQKAKHALTTRRPKTDLGFLRQEEDGTTSMTILNPWNDGTVSSTQKVISLGDYMGKLKNGSGTLFKFKEDKRNKVCPETYLCYGPFSSHAPAYDSSFASCTKEESDLLLGTYGGETGVQYAKSVQKFVENAGISAVEMVDKLLDTLTNGQHSKARLRQEEQKRREEELAEKALQDEMIAKAQKAAEEAERAAAPKDPVQHKLNETAAILSELSQTQKERLSQDPPPHLGFIAQPSDKEADLANKVTDNLVTMAKQVYPGDVVSTGAVRSAMGITNYTTSGPNQVGARAQASSLSGSAQNSKTSDRQKSATVVDDSDDDSGDEDDDDDDDDDDDDADDDDDDDDASDGEGESGNDGMDSVDDSADGAGASGGGEAGDTSGLGMEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU90</accession>
    <name>A0ABM0JU90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101850966</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101608.1">
        <property type="nucleotide sequence ID" value="XM_005101551.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850966"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00103">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF17">
        <property type="entry name" value="IRF TRYPTOPHAN PENTAD REPEAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00267">
        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="2">
        <location>
            <begin position="59"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101608.1"/>
        </source>
    </evidence>
    <sequence length="1413" mass="151442" checksum="4751C15F1C1CF908" modified="2025-10-08" version="1">MELDPPHSIEVITVTTTSNPGSSGRSVIPLQIELEKFPTQQEIEGHDNKMRRPVRPIDRQRMRPWLMELLDLNNVFGLRWTNRHQGIFQISWRHASRLGWNLETDGDVFERWARHTGIYKEGDPPEPKRWKANFRCALHSLNDVVELTNAVERRGRNACRTYRFLQSGDDQVLGRKRAKAKKAREAKLSAYERSLREPVRQVVVESASSEELLSEGEAEETTQDKVIVQKVDTKCEIAGEEYGLHHDHDYSAGPDKTVSEKTIVVRQGVGSIVLQKEIVSAPEPDNSTKNLFISNLDQLASAAMSSAGLEAGTVHEVEVSSSNRKVRQQKARKHRVESEDLSKKSDFSLKRLLTGGKGREEGQGSEHGPVTRKRKASTSFEMNSEERSEQFQVRAAKNRRRKLSEPTSPAKSSRSEAVKASGLSPPSPRMTRQRSERSSSPKIRGRKTRRGKKEEDEKSESTEPLMSSCLLLLEAATRLDNAEKGSNSSLRSSGSGETNISLSNMEVCEESVVETTVESEVPLSDHNVAQEVDITDIKLEPTEVEKSGDETKDETDDAGLTEAPHSSSPGILRSTLETIGTELKADDMRPRTRSGKSFLDSYSMSVSEGKIVVVKDSEAKGLFSGSSIQSEPNVSSEYKRRGRGRGRGRSSRGKYFVDIRTNSGPALTLMNNGDERNPDEVTMESVTTDGDVGKTEYLEEMEVPQVANFATVKSNSGVQQTVIQRALPVLSAPVQKSGSSATEFSAPVVIAHKVSGLAGTPQILMTSTAVNPQPSGRPVVASQKLVAAVANKTQSTLLPAQLLSKGLKNQSLMPGSTLPSVTKLAGSQTVGSVLPVALGSSMHVTSAPSPTSPIIANISAVSMSPGSGENPQLLSLPSSSISSLMNIKAAATVGPRTIILTRPPKTSVVTTSAAVTTTATAAAQKKEVATLEQGKEVQNEVKLHVLPVKPTTQLPNHSHPSVQAENALISQLQAHVTSAIQRESENPAQGVSGQTTPTQAVNVTAQIIFDPIKGPMLKFPIGPPLPLHSSIFQPQNFASQAQATSRTATGGADSTVVSSPALNSSTTLVNCADRKPTVPVVLGTKVFVDNPSSPPNSEAGSSSSSTATPTSVSLLRSQVETSKNSTVESKPDAVTTLSITKSAPISSSGESHVQQGTVSILPFGKMTSKFYPLKALQNPVSLLHKHQQGAAGANSSIVMDFQQALLAHRLAMPDGSEATVAETVLSAGSYSSVCQEDSGEVKPLAELCKSLLAQFFKSLDNQTSESEASGSSFSSPCVDVKQDPAVVQKQQESQQEPVLSDLKGVNCTESAQVSRLGSTVASNLKEEVELTLTDNNECIMASSSAIAGPADSEACSQQDSVMTEVGDEESKRIKYDSNIVMDPTAPLSLGEVPLFASGKGDSDSMSPTSDGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV75</accession>
    <name>A0ABM0JV75_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bcl-2 homologous antagonist/killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101851280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102292.2">
        <property type="nucleotide sequence ID" value="XM_005102235.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851280"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF41">
        <property type="entry name" value="BCL-2 HOMOLOGOUS ANTAGONIST_KILLER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="5">
        <location>
            <begin position="107"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005102292.2"/>
        </source>
    </evidence>
    <sequence length="248" mass="27255" checksum="517ED68A8EA443E7" modified="2025-10-08" version="1">MANSNSDPELQSGLNYDHSDNGNNGRSLLSPMGLGGLVRVRSAPHMMQPDSEENVQAQSEAVFLNYVYQSYRNDSVRTDVDSTPAAPELINFPASPITPAAEIGRQLARLGDQINERYSDVFDGMIANLNLDSNNEDAYEAFACIARRVFTDGSSWSRVLFLLSFGYRMAINTLRTQASKFASFLSKIVSFVCRFLAVEKITKWIADHGGWRAALSFVPGASSNMFVLISGLAALSVLAVFALHKYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVG0</accession>
    <name>A0ABM0JVG0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIA subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102485.2">
        <property type="nucleotide sequence ID" value="XM_005102428.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853176"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005102485.2"/>
        </source>
    </evidence>
    <sequence length="349" mass="38659" checksum="E2FA0E383F40203F" modified="2025-10-08" version="1">MSNASQVSKLYRTVVEDVINNVKEAFLDEGVDEQVLQELRQLWDNKLAASKALEPPPSDTELVLAPGNLMMLPQSVQGATAAATAQPGQQVQPQATPIQAANQQFQPSAAATTATLALPSGLFQQQIATIGAGGQIQNITVQQTGTGQFITLSGLTPQQLPQFQQQLQQQQQQQQQQPQRAQLAPQITPQMLQQQQQQQRIHISPQQQQQQQQQQQPKLLQGAQILQSAAPGRTSQAQALQNIVQLDGPGDSSSSEDDGEFDEEKEEEEEKEEENDDEAQGEEEEPLNSGDDVSEEDPTELFDTENVVVCQYDKINRNKNKWKFYLKDGIMNLNGRDFVFQKATGDSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWS9</accession>
    <name>A0ABM0JWS9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RIIa domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103385.1">
        <property type="nucleotide sequence ID" value="XM_005103328.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863201"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22971">
        <property type="entry name" value="DD_RIIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059162">
        <property type="entry name" value="RIIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505:SF4">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103385.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12676" checksum="6530CAA64B59E640" modified="2025-10-08" version="1">MSDQPKHGAPHGMEKYDLGGGDDLGALSLAQQADLNQFKISTRMGNERYLRDHPEVESLIAGFLGDVLTQRPESVREFAAGYFTNPSLPEKVEKQLAERQEKLKQNRVIQSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY44</accession>
    <name>A0ABM0JY44_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC101855356</name>
        <name evidence="11" type="synonym">MCM7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005104285.1">
        <property type="nucleotide sequence ID" value="XM_005104228.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104286.1">
        <property type="nucleotide sequence ID" value="XM_005104229.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855356"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="12">
        <location>
            <begin position="334"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005104285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005104286.1"/>
        </source>
    </evidence>
    <sequence length="723" mass="81811" checksum="FDCF0B8C0A3FA87E" modified="2025-10-08" version="1">MAPKDYAAEKEKVTTFLKEFYRDIGSRKKDFTYANQLTKLAHREQVALVIEGDDVNEYDPDLCEAILENTRRYVQIFSDAVHELLPEYKKKEVQNRDALDVYIEHRLLMEQRNHPDGQEVTRDPKNRYPPELIRRFEVYFKAPSNQKFAAIRDIKANNIGKLVTVKGIVTRATEVKPMMTVATYTCDTCGNETYQPITSTAFMPLLMCPSQVCTTNRSGGRLYLQTRGSKFVKFQEVKIQEHSDQVPVGNIPRSMTIFCRGETTRKAQPGDHISVTGIFLPLMRQGFQQIAQGLLSETFLEAHRLVQMNKTEDDQNEAQELTPEELKLVAEDDFYDKLSMSIAPEIYGHVDVKKALLLLLVGGVDKSPKGMKIRGNINICLMGDPGVAKSQLLSYIDRLAHRSQYTTGRGSSGVGLTASVMKDPVTGEMMLEGGALVLADEGVCCIDEFDKMMDGDRTAIHEVMEQQTISIAKAGIMTSLNARVSILAAANPAYGRYNPRKSVEQNIQLPAALLSRFDLLWLIQDKADRENDLRLAKHITYVHQHNVHPPLTFQPLEMKLMRRYIALCKSRNPTVPESLADYITGAYVEMRKEARNNKDMTFTSARTLLAILRLATALARLRLADTVEKEDVNEAMRLMEMSRDSLNNMHDAQTRSQNPTDQIYQMIREMAPATGAKSVKLSDVMEVVTSKGFKPDLVQVCIEEYEDLNVWQVNSARTRLTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYA0</accession>
    <name>A0ABM0JYA0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860674</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104396.2">
        <property type="nucleotide sequence ID" value="XM_005104339.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860674"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF1">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104396.2"/>
        </source>
    </evidence>
    <sequence length="604" mass="69601" checksum="11176E0C4C5410EE" modified="2025-10-08" version="1">MCRPLLIAFRRYIPLVTSFRERYAKTFLLVCLFSILLSAYMSTYLLDSVRRIQDIGSENNLILYREVYRHEAWPEVEGVVKDPGSLPPNAHYFWCGEKIFRFEDYLGVLSIVRVLKPVKLIFHYNTLPSVDDNWYHTWFQELKQSVPNLVLQYHVVRHKCGSVEALRFYLGTLAEEGGVYVGERTIVTEMPEVEGYRESEVFHSFRVNELEHDFTQGLVIARRGFPRQQVAGLLSSILNHDKKCYDVTEYNRIFPSSSSSSSSSPSSSSPSGDSGPLNSNKNSSSFSPCLVLSEALVPKDIVTSPTPLAELSRWLFYGERRARQVTPDPLGTPLIPLISHIIWLPPTNIFKSSEFKLLHYLSIMSALHVAGFRRVFVHGAVRPHGHWWDQLRGENVTFLKISHPESIFQQSVVGPAHQSDVLRLNLLNTYGGAYQDRDVIWVSEIPESLRRYPVVACPDWPINGEWPEVFNMGVVLAKPGAEWLSHFLNTFRYYRDDKWAFNAVFMPYKAYEFHPDKIYIDRRLQIICFRGVCHPAWHKDYKRDINDQRPINFQWQEGRSFHFTVPKPAPGLASLEAIRDGQDMFSEIGRMILTKSGRTDLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZB3</accession>
    <name>A0ABM0JZB3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Histone deacetylase complex subunit SAP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the tethering of the SIN3 complex to core histone proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105071.2">
        <property type="nucleotide sequence ID" value="XM_005105014.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859188"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017250">
        <property type="entry name" value="Hist_deAcase_cplx_SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037637">
        <property type="entry name" value="HDAC_SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005105071.2"/>
        </source>
    </evidence>
    <sequence length="153" mass="17380" checksum="CC5E935E93FA59B5" modified="2025-10-08" version="1">MATLESMVVEDQREQEKPIDREKTCPLLLRVFCSNDRHHPLMEFSRGSTPTNELQIYTWMDATLKELTGLVKEVNPDARRKGTFFDFAIVFPDSRSPTFRLREIGTTCAGRKSNDDTVTLAQKKFTIGDYLDIAICPPRQGGGPPMGRGRRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZD8</accession>
    <name>A0ABM0JZD8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105117.1">
        <property type="nucleotide sequence ID" value="XM_005105060.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849393"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005105117.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38637" checksum="452A1C54279EC15B" modified="2025-10-08" version="1">MVLTCRFYKNKFPEVEDVVMVNVRSIAEMGAYGRLLEYNDIEGMILLSELSRRRIRSINKLIRVGRSECVVVIRVDKDKGYIDLSKRRVSPEEVIKCEEKFAKAKAVNSILRHVGELMGYKTDERLEELYEKTAWFFDEKYSKPGFSYEAFKHAVQNPNVLDECDIDEDTKKCLYDNICRRLTPQQMKIRADIDVECTYYDGVDAVKSALKKGLEMSTENMPIKINLIAPPLYVVTTSTLERNEGLERLNKALDAIKAEITAAKGVFNLQKEARVVSDIDEIELEKQLLKLEEANQERAGDDDSEEEGDEDEDDEEGEGKGEKKGGEEDGEEEDGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZU5</accession>
    <name>A0ABM0JZU5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Gem-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101857272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the core SMN complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105416.1">
        <property type="nucleotide sequence ID" value="XM_005105359.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857272"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017364">
        <property type="entry name" value="GEMIN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038038">
        <property type="entry name" value="SMN_Gemin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005105416.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30046" checksum="222AE6002D3FE472" modified="2025-10-08" version="1">MADSDSDGPCEPALAIDESVAADMDLNVPATSGNEYLRRVRLEAMECPKVVVADMDTSSFLTQQTVKVSEPGGLLPVPVSYKAPMSWQRMQVAEFAALRQKLIQFKALLKQKKINVPSPKLPQANDADTWCRLCFGRLKVKIDQGDNSSTNASSENEKVPVDSPGEGTPPLLHIVAHMNQHQVTCVLEYHTNWLEATGFTSAQGRWFYALLANLQKPLSPEVCSWLRRLARLCSNIRASLEDVDQPMLKELNLIICLVSRYFDQRDLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZV1</accession>
    <name>A0ABM0JZV1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Toll-like receptor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101860761</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105430.1">
        <property type="nucleotide sequence ID" value="XM_005105373.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860761"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046336424" evidence="13">
        <location>
            <begin position="28"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="14">
        <location>
            <begin position="821"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005105430.1"/>
        </source>
    </evidence>
    <sequence length="961" mass="109188" checksum="ED4026548F7BE177" modified="2025-10-08" version="1">MALLKSLPNRNPIVLLFMVLALGCMKSSQQGSDLSPATTSHTKESTPTLNTSLGLSERSSTALSTYSGSGEETDWGEVDDPTLDLGSKQFADTSTKKYAQEVLTGSTPEPSSCSTQNSPCTVTVQADDVIVDCKGKRLVTLCSEWFPIDTTILWLDNNCLDSIEKNVFSKLSLLRALSVTNNVINYVEDDAFYGLEKLEVLNLEHNGLDDYYACFLWAMLDDDEEAGVLKHLPALREFRANYNYPSTDMCDFNQFIVEIRHLSKLQLLTLDIFGPELEEHTVSTRLFEKLTRLEMSLFSDTLSNQTFRAFWNSSLTQLIIVNAPQLKVIEEDTFVPLRFLETLVLSNSAVGFGNCAQALKPFVGRLLTELVFDNVNLHEKVFLNSYSGCPKSEVDRFPFIGDCSELWKYRYLPHICSERISFKSNNIASLTFAFSEGLTSLYTCTRVLDLSGNDQFHLDINLWTSLTELSVTYSKKMWSFRDNIKKQYLDGLRDLNNERSTSRCDPDGSEIVDCISPDEVLLVSSLRKLNNSASVLDYSTRVCNEVEYFNATGLEELDLSRNGFRNVRGSIKGLKNLKRFIFSHNDLAEFTDTYFDHFPNIQYIDLSFCNIQDSFLTSRGRRLFKNVLKLKQVVLSNNDLSVMAPDTFEANKELEIIDISRNRFSSLPIDVRYTPSLQVLNLAHNSLSFFTLEGMKKLDEHYRKQSNFTLLLDGNLLSCSCDNIQFLLWLRSTHIALDKAANFTCISKGAVVSFTQDIPHPKVLWRQCFGGTSLLISLSLLLSLLLSVLSVVVYFRNRTFVKAFVLRALMPEFRPKKREDYPVGVFIGYAERDYRFPCFPLREFIEGRLSLTTYIRDRDMLANQTMGDAIVRAINASWRLLLVVTHKFLDDDPWAHFTIKTAVYSVTPANPHRLVVLTTYDVKRRLPADLLSMVSESNIIVAPSFRMNYGLKEQLRTRLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0F9</accession>
    <name>A0ABM0K0F9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable beta-D-xylosidase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105841.1">
        <property type="nucleotide sequence ID" value="XM_005105784.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854039"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF42">
        <property type="entry name" value="FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046922551" evidence="4">
        <location>
            <begin position="20"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="5">
        <location>
            <begin position="679"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005105841.1"/>
        </source>
    </evidence>
    <sequence length="773" mass="85610" checksum="5ED3FF00B1A60B22" modified="2025-10-08" version="1">MLSRLPYGISLLILTAALSSHIATSSRLYRPSHSNTIRHMNIDEDQAQFGDFPFQNTSLSWDERVDDLVSRLTLEEIQVQMARGGTKEIGGPAPAIPRLGIGSYQWDTECLRGDVDAVENATGFPQAIGLAATFSPDILYHVARATGQEVRAKHNDFVKRGIFATHTGMSCFSPVINILRDPRWGRNQETYGEDPYLTGNLVQKFVIGIQGEDSRFIMTSAGCKHFDVHGGPDNIPVSRASFDAIVSDTDWRMTFLPAFKKCVEAGTYSVMCSYNSVNGVPACANKKLLTDILRTEWNFKGYVVSDEAAIENVISKHKYCNNSVDAVVACVNAGTNLELSYNLPTPVYMSIVDAIQQGKLSEDLVRERVKPLFYTRMRLGEFDPEKDNPYAKLGMDQIESAEHQQLAVTAAMKSFVLLKNQGGILPLQKGKFSKVAIIGPMSDNAEQLNGDYYPRQDKSFFTTPLDAVKTLYPNAKYGQVCKDNTPCTQYNKAAVPAIVKDTELVFVALGTGQAVESEANDRPDVELAGHQKELLLDVLDNSGDAKIILLLFSASPLNITFADQSDRVVAIMECFFPAQSTGKALYNVLTNTGPYSSPAGRLPNTWPLYSTQIPPMVNYSMEGRTYRYFRGNPLYPFGYGLSYTQFNFSDLMYNTTIKAGDSLSVQVDITNEGDVDGEEVLQCYISWNDKSLPVPQLQLAYFDRILIASKQTISRRFSMYPESMAFWQGGKWVIKAGGMSLFCGGQQPNQKKQVPSNVLSGTFTITDSITLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0W4</accession>
    <name>A0ABM0K0W4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptides capa receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101846024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106139.1">
        <property type="nucleotide sequence ID" value="XM_005106082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846024"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005106139.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="39929" checksum="6080A2ECB7DC43A6" modified="2025-10-08" version="1">MAVNISDSIASPSGSSTMLGTSDIYLAFDIALNCFGNILVSILGILGNTLNILVLRKYGLRDSTTILLFSLSVCDLLYVLSTPVLRISCLVSFFDSLLAVSIESLAFAYVGMFNRLTNLLSVSHIGIISVERFTAVYFPFSVSRIFTVTRTKQLLVLLYLAQTLSVSPLFAIFTYQWVYIPEYNHTLALVESSMFYTENYQQINSYSFIFLNVCGTVLTLVIVLFTGAAISAKLLLTSAQRKTMTSSTAARNSKSSREGADAKALKMIGVICAIFVLIFGPASGWDLYGYALLGGEFYTNSLYVAVQRFFDFLYTVNASVNFLIYVSMSGKFRATYKKLFLHSHNTVTRTSESKTGPKTSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K272</accession>
    <name>A0ABM0K272_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101862892 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106998.1">
        <property type="nucleotide sequence ID" value="XM_005106941.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862892"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1438"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1625"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1446"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1630"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1671"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1690"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1727"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1758"/>
            <end position="1771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005106998.1"/>
        </source>
    </evidence>
    <sequence length="1798" mass="205861" checksum="123B5FADA648F222" modified="2025-10-08" version="1">MYQQNMKAKIIQFITKHRANLIRSSLLQLLIGITMQFHGIEHLRHSQRRSPKDTSAHSLGTKSDWDFLHDRRGSNLEKFENIRTPSVSKTVIRREKGRTIAWLKTTSDVKAPSLWSTFFRRFLLNIPRTHLSRFEAGTRTVDMVSTLQRQSRRLRVKELLLKPDSITFNEKKGFPWLKAGNKVEKKKDKFKEDTATTRGKHLQITSLVLKKKLKSSMWSDLKNASRSLYNFKHQYTRATSPLRKSNIYNLYLANQRDRRLFFLLKRARQMLFVRIHDQEEHVRHLREILQEERKMTDSLGVNINKVTRGLSQCLQWLRAVLDGVSLMGEYFKGKDVISYLDKGKISRVNNTTSYTQKALLPLQVKITVSTNTSFPILEYLFQVFNHFYNAFMYVIRGAPKAIFEALQKYQKWNGSRERDAGYSVETGRSHYEDLRNETKDAVQKTIHLAIHNAEESRGSLGTGSKSLWSRSDIKPLSMDVLESLGRTSVKAKRETSVKPAPQENMVVEQSDIYSINKRGGRHLLSYPQPRPNNKQHANTRQTKHGGARKDDEMTNDFDKVPHHIPPGYSDSHPGRLAAPYEDSSRYELRRRIKNRHRQNFFFEKSSNMNPLSRDIRFDRSPLRQSEHRSRATERQKTHRDKHNLPTVTSEPQTNDKAYTTDQRYGTASRKWSHSDITADKLRGKLLALLKILHKKRLLSKSDRTVLSRPLEKAHDSKESSTNKDLGNEEKLADSTLSNILARKTENQMDLGLGSGGSKAIRLTQEERDLGFPFHSFRLQQNKFLHAEPTEADRQVLRNIELLTRRVLAADEDIPTTIDDGGEIYQTHDEETVSTVTDTKGESDGAEDGGGENGAFSDESDKDKNIMKSKRRKRREVFAGGQSYSNRGKKNSTLKSKLRGKTQVVEPKADPGNNLKNSVFKKIHEGVPGLPSRLSKYYANERVTGRSVSVKSVSRRERAAVQVDVVDRYGNKLRATHEEQMMNNFSQRWAKLRPGLKKMQRNISKGREKFEESERQLVRLLKKGDKLANMVLVSNKRSRVDEAMRKAAFKNAETEFRRYKADLKLQQRKTEAKEYAAMTDDISKKISLVKNVLAKQRAYQDAKEETEFELGPYAPFSFENRNAVYKVKGRDGLHDDDRYVLVDEEGEVEQLGSEDQAVNRLAILYFEGDRKVHKALAATTKGVVTLDDYKEETKSDPDLLKVDHMLTNLLQRNRRSAVVGERNADDDPLRRLEKSDRDTTYIGDEEKVDDDSDDGVHDVSGIVQNPNLDPILSYAFEKDIPTGDSDPDADPADILFNNLGKEKDTRSHREKVDNNYQKNVLPAEFIPERGLTSRVQPNQIHILDSRLSTLGNSKTGNDGYLEHSPMSFSSTTSVDDNLDILEKSKSMEAVPADLVLSVQFPNSVMSGKYDRGGLGKQNAYGKENELNSVKLAVGNNGLGGKRETHSQRYTPAVSPQNPLGRAQEMFSTSRHPLEMGDVTDLGDINDDEVDAQAESVLIRHGVFPGDGGLLDIDKEMQKIDVDTAKGHYESALFDRNRNMGAFDDIVEASIGNVTLADYKDINWDAMERQKGEELLSQKERNDIDMDKKKLDTTFAKLEKAENELKQKLDDEEKNAVKEIHDEIKARRKEQKHIDKELERDEKQKQMEETDTKHAVNELEKEMEQRTKKKIEKLKTKEKELDRALKEKKKKSGEEEKLAKEDKKVKNKEDKESDRFVRIRVDNNQTMRDFLKENKGGRNSRYEGRVADEKTKEDLNGEGVNEDIESGDLEDAEKENQEPTVATVEGGDEESGPLSWFGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2C3</accession>
    <name>A0ABM0K2C3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC101845193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101845193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107090.1">
        <property type="nucleotide sequence ID" value="XM_005107033.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005107091.1">
        <property type="nucleotide sequence ID" value="XM_005107034.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845193"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005107091.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40480" checksum="335F50E096ABB7CA" modified="2025-10-08" version="1">MPSASMYASPYTYKEPPRRINYPPLFSSLNNLTFRYIFDSKILALSALLLLVSFIVITLMAIMPFWFELVLSQQDGTFGQMQEKPGITINTGIFFMREDHFDNLIFLNKFSNEDVVPKTLAFAQVCSIIGNCIITCCLVATLILVFRRFGSATGTIMLAGAATVGALFQILAVVFCGVLLLQSNCEPSDQTDENGVRTASSDCDYTENQVWRMIPMYTQLYRVEPHLTPYVKPNWAFYIAALGALLCVASAVMLWLEAITTGKSLKGIRYQQMRQVRDPHENDIAPTGGRKFVYAAPQNYGPGSYGMQPVMAASGPYQTRPMYAPPHPPAIGFGGPPQTIGFHPGMSRRPESESGSSGVVTREIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4F8</accession>
    <name>A0ABM0K4F8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101862975</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101862975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108516.2">
        <property type="nucleotide sequence ID" value="XM_005108459.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862975"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005108516.2"/>
        </source>
    </evidence>
    <sequence length="616" mass="69430" checksum="6DE8D22A2DB90DA1" modified="2025-10-08" version="1">MFHLFFSSVPESVKILASRVLAELLLTVGKSMSLLMSCDEQLLAAGLMHIRWSPEQPGELERSLCREEETVTALVLLHVSYTLGFRVVETEDMLGVLHKVAVVCPDMAAHLEADAVQSFVFLYSLTWADLTEPDIFILEDLDHWLCGQLVRCPVQKWSTLDSLLFRWCLSSENKSSRLGVHLVEHWVMEVGVAYASDPSFDFDSDHRHGKIFAEAKQSFHFLSSLLSFWSKEQPDSCIARTAVDILLWWINLISSERATEKTVSLYQRVLSHACRHFEKAVCSSVETIDKAERFLLPIICAMLKSPLYFGDLWTFRLKTTLHVAKLFCRDTLESMVENCLQFLSAVCSVLQKQDSKALISPLMQIEGFARKLGSAFESSRESVSALAVTVINWLSQNGQSYQGNQSVLISVQQLMSRLAAAPARGSCSLGLVRLVRTALSAAENGGRVSCGGAVEFVKETQTCRLFDKIFSTTELRQIYVCLQQFLLEENPDVRLLSVLCVGSLLQVSEEVCQYVVQQPWNWTLVNSMLSSRASDRLTRAEVEFCHLLLMNGMELFRTKATADNYLTALLKSELSEEMFPKAEWFVEQLKNASVSADKELLSAAENHLLRFRDLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K589</accession>
    <name>A0ABM0K589_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852277 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109062.1">
        <property type="nucleotide sequence ID" value="XM_005109005.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852277"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005109062.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20715" checksum="E8CCEA08D7C92043" modified="2025-10-08" version="1">MWQYLWAHAIFHLVRWFPPSNRVKITVVAVFATLCLLIPQFYVLLQDKTTRWCPEPLMPLLITSIIFTFFVIGFTFLFVTMVPVPREVKLTFHGFGLVTFITGMIQCVSTSKAQDCDFSTPELYDISLALAVLCGVSIVYVAVLLPFWIINQVKQNAVLDKGERRGVCYEPVKCCSCLWHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5Z7</accession>
    <name>A0ABM0K5Z7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Caveolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101860610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Caveola</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the caveolin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109531.1">
        <property type="nucleotide sequence ID" value="XM_005109474.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860610"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001612">
        <property type="entry name" value="Caveolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844:SF32">
        <property type="entry name" value="CAVEOLIN-3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01146">
        <property type="entry name" value="Caveolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005109531.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14576" checksum="4260D7BC93D1E2F6" modified="2025-10-08" version="1">MAEIDLVNRDPNNINDHLKVTFEDVLAEPEGNHAMDCVWSNSYKCFNCCKKLCYTLMTLCCGICIAAGWGCEFAYIAFVHIWYVTPCFKCLELNCGCLQKLWGMIVHCYYDPFFETMGLCFSAFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K696</accession>
    <name>A0ABM0K696_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutaredoxin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101863301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109712.1">
        <property type="nucleotide sequence ID" value="XM_005109655.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863301"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005109712.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11726" checksum="CC20B6FAFAF321AB" modified="2025-10-08" version="1">MSGVKEMCDSKIAGKKVMVFSKSSCPFCKKAKTALQKYLGKELPPEDYEVLEIENMSECQAIQDYMQKLTGGRSVPRVFVNQKFIGGGDDVVAKDKNGELKQLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6J8</accession>
    <name>A0ABM0K6J8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101855529 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101855529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005109935.1">
        <property type="nucleotide sequence ID" value="XM_005109878.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855529"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1865"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="2177"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="998"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1085"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1402"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2050"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1149"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1169"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1202"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1245"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1277"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1293"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1321"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1348"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1402"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1414"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2050"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2076"/>
            <end position="2086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005109935.1"/>
        </source>
    </evidence>
    <sequence length="2311" mass="255662" checksum="F9B09D1E3F15B80D" modified="2025-10-08" version="1">MASEKGSSAVNWEALGILTCERCHLKTSDKTLLQFHNCRISKRKVSSSSHVSRTAPCTEAVVANTASSSNTVPLAVSREKPGSSAGVTSVTLPRVTAVVQYNRAKGTFACSLCREGYNEQEFIEHLQSHMWLKPYKCNYCVGEFETRDAIYAHISTEHVGEELRVCLKLSPRTKDVIYGAKGNSKNTYFFSALKGNSCKSKSDLPQDGSLRQCSVSINQSRSVVGPPQGSQEIVTSVNQGVPCIIVSVAVPVASVAGVTPGGSLIVASPKPSLCSITSMTTTSSATIPRLSTAQPSNPTSIAQSGSIFRPHQMKPNANQQMAGAQLRFPRVLAPVPSAGMKSDTHRVCRSVSLNDGSLSQAPDLRRSLSAREGNVSTSLSTLSRSADCPVTSRKVSMKLVNSATESSVAACDNTYGYDQIMKEGQGAKVSQSNKVDMKSTLRALRGVFLCMTCKIKWADHQVLLFIKHVWEHIHPGTCQCSNEFPEKNPCASLKEALRVIFSNSLEKMPDEVKQYISRVTADSDKEDTPVAKKEVEPLQTAVTTDIPEPSNENLCPSNHSVPKASESSLPEKQVENNVCSASPIYSSSALPHGSKKTIPCHVNNSQAQSNESSLQKASLGNALIDDTRPADEFLLERNKEPACVSSENERLIPQLSSEQTSNSLTNVSSKAANRRCNSDAEKSQSVESESELSCFYKCGFSQCTFSSYKPMELLLHTSQAHGLESEFPCVYCGYIGSRDSVLLSHMQEHICDEEKSKFMYSCSLVFDSGDVKDLRHQRLDVLFSMVNSYMMGESSMNTSFKLLCKYCDQTFDEIGDLKQHYDDSLLLTVVECRHCMGYFLDSASCKRHISREHPNSRVFYRFSKKLLCKKNEVMGAAFEKFKKAYKDKFVSRRQSTGTDLSDNIAVCRNICSPDPMSKAPQGALNRTPVCSDVSDTNLVQQKNCEAFNYTDGQAEKIPKENGVCNSTPPLVDLELLGVIRNECVEDGDGEVSSVAIQSTSDLNQGNRMGETGDTGHDKGTTNSAEVSTVRRCPAQDLISSNLEPSKNTSSEVCGQKTSLKPSWELHSECVDVMEVPNGENEQAVKIQSSKKVQNEIDVSAESSDVPIEKRDSTVSSVSPLNIALQGNDDQGEKDPNCPRKKQSPNTDIQGEKGDDQKRGGKSSDAYCQKQKEDSKKEKQRSIVSECVDHGENDQLLKGFKGQRGDHNKTEKPSDSCSREEKDQNHSTEEPNVSLIDGVVHNNSCRAEKQKFSDTVCEVDKDRDNRTEKTKSSNAGSEGKKDQDYRTVKQSSHGRTEEKDHEDGNELECSSSGNDQGGKPCRLVEKQQTSDKEKSISVSPQDFFCAPSRSKDKSEHHGKDLEKLRCSVPGSDIKSVQESETVTEEKEGELENVVHCDTQFVTDSVTSDNSSSPSARDRLNSAENEKSVASGKVMNSSLSQRTSASDNLFERIGSDILAAFSNSVHRPSSKLPEKTKQLVLNTEVVETLEQPDVPVPHDKDKRQGEVQLLRLYDTCGTEALDCLDSLYATDRNGKYTCKKCTKRFKGLKIIHCHVLWCVGGIAIALCPHCLYKDAHPKLITNHIKKMHPGEDAEEKLFHQVDWPYLSNTLQSQKLNIDNFRNICKPFTAVNVHAEKAQEEHVEMLCSESQESDEKRGQAQVCVEKECAGDKTDQATEKLCLEVIAEKSTSHSCLSEKRKASDHLHPLSSSSASKQNKVCANTEPSIPVVSECQVEETSLSSQVLNENYDSNEKQVNSMHTSVDNVPQNSHQDIQSSTGLIESHSSSKSTVLFMCTHCTYKSYSYTVAQRHARHDHEGTLAKVKKVSTQEQNIEESRERYKCRLCPVEYEKWDDNAMQKHIDEKHKFFECSYCKFPYFILSHLYNHMKFAHQDDGSKVDKLSPSSVFVDVCDAKSKPILTLETEGLLVQKGQKRNMNQNETDAVGIKTVKRRCLKKYVGLKKGKFPSKELTFMGNKLPSESENEICIDLTTDKDDIEASSKSEKQMTEVPVSEIVCNICHAHFKCFKTLKTHMGLLHRTLPFQGIGRQLNPVLSKSSADTPMTNELPAGTASDDKDQSESPSTQNGKSFNKTEEFLLNNELAESDACANMPVSSLTDQTESDTVTVSQDTTHVPAHSPPTRYSCHLCDAILSTEFFFRLHLAKHGGFSKLSVLTSTDGLLLCSKCGYIAVSMNDLAQHTASHMDERRYFCSLCGADAHQKAGVTCHIKKMHREEDNAMVKDRKKQKESVDLKPKLVCFDPMVCIVDPFKQTPEDLRNLLSRNGITLLDSVVDEHSNILDFVKDDELFEVTIKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K815</accession>
    <name>A0ABM0K815_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTPase IMAP family member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110990.1">
        <property type="nucleotide sequence ID" value="XM_005110933.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853357"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF184">
        <property type="entry name" value="GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="7"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="267"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005110990.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43657" checksum="3FE76B6632560D47" modified="2025-10-08" version="1">MASPGSDDSIDLFLIGKTGHGKSSSGNSILGREAFHVSDNTESDTYDVQVGWARRDGRKVKVVDGPGIGDTRMQRGDAVQKMVQDMGQGIVQCPRGFHALLLVLKYGNRFTEEEFGTIEFLKSLFGPAFVKDFCILVFTHGELFDINNKKRNPPISFEDWRREQKGAINDLFNECDNRAVLFYNSDEEKMEDQLKILLGIVDGLKSRGKRYTNEAFDKAAKGREELIVRENAPKLREEIQAKIDILVDGLNSLRQCSELDPVTKERFDQLKKDARELEVEIAEQDKGTGVLQQLNQVVKSIITNINSHMEVMKAKLDKSEKERKMRLVQEQYTMNLRHLENEQRERKQGWGAFFIDIFKSIASAFVAPAVTFAAKKILQWFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K959</accession>
    <name>A0ABM0K959_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101862916</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101862916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005111850.1">
        <property type="nucleotide sequence ID" value="XM_005111793.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862916"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005111850.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33160" checksum="350972D870D23296" modified="2025-10-08" version="1">MDVEALIDAVFVRPAIWDRNDKRRSNRQVVDKCWADIQAELNVEEMLLRRKWKYLRDQFASEWGKIETLGANSCQVVTSKWQFYKQLLFLKGVAKPRTYKVVPHGEWDSTRGGEPGRDSSRDWEDSLRSEVNAGAVNNDNSNSNAGEPSYVVAVSDTSENGEEDGDTRATTHARDTHDTRESQHTSTLYVRGKRKRKRKRLGNATGEGNEFHPASLANIYDSLETIIHNTNPSSRNVGPTEDDDDLLFLKSLLPHIKGIPMPKRLCFRGRLLELVQEFAYPPPEDQKFLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9P6</accession>
    <name>A0ABM0K9P6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane channel-like protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101863791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112282.2">
        <property type="nucleotide sequence ID" value="XM_005112225.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863791"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF24">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="888"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="708"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005112282.2"/>
        </source>
    </evidence>
    <sequence length="958" mass="110676" checksum="6DDC5CD4DC8003C7" modified="2025-10-08" version="1">MDRRRVYTYPEPDNISGDYDNSQDGGYADDAAYDSQYVGGHTRQDSDPPADYELGNSPHVRSNNINNNNNNNFGSVVRDDDRYQHAEPRYNSRESDRHVHDMEEGGVGVGGGGRATGHHYERHGDRRESAAHEWLRHRRTKSQHLNGYDFYRHQIQYHVNRGFQHDDDDNKDGVDNHYNSRVDNDDDADRRSVQSLNFEDLKRARQILATVRVRRKSRKHSSRKRRSGGASSDDEDFVDDVPADYDDDDEEEVGLPSAREKMKSLAERLVLAKQLQSAKEVARQYRDSLWALDHEGVTFSSGRVPKKLQRVGGTFSDALRVLNFWSHQFKEIEGHFGIATATYFRFTRWLVKINFLVLLLFLGFIYIPQLTYSTIFSDQQPDQVNITDSSRFYEETFKCSNAYSDHLDNITRKESDIDKFLNIALGTGFIENTMLFYGYYSNLSFWRGQDPGEEVFGSHYNMGLAYLLTVGASFIVLFLLIVKNSSNTIKETVMDFDQQAFPKYANAVFGGWDYCINSENMAAFKQNIIYKEFMADLEEIKLKRKKQNRTTGERSKLYLKRFGINLFVIALLGASFYAIFAATDFLLEKQTEQLSFIVALLIQYLPSIIISVLNFFIPEIFLKLAEVEEYSNNFTTRITIVRAVFLRLSMVGVLIVSLYYQLQYERERTSYTCPEEENFFPNVTRCCGNPMWKIPDSPTEDEKGTVKCWESYVGQQFYKLAVADFAAVTLATLLLKLPRRLVHSKLKQRVRLVSTLGLAKFDLPLEVLDIVYSQTLCWVGMFFTPLLPAITFVKVFFFFFLKKFELLFVCETPKNAYRASRSYSFFQTILLVSFIMIAGLLGYMIGNIQPSKSCGPFRLYSSDQYVMFDTVSNQVNSWPSTPRNIVKYFGTVAFFLPAFLVLLLSIYYYWATSQGYKKMEKLLKLQLKSEAYDKQYLLARVDEVIKKGQLVTHDNEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9W8</accession>
    <name>A0ABM0K9W8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uridine diphosphate glucose pyrophosphatase NUDT14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112432.1">
        <property type="nucleotide sequence ID" value="XM_005112375.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860143"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF15">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005112432.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17546" checksum="51AC40F565CA38B0" modified="2025-10-08" version="1">MILSAVYLAEAETEVRGEHEVIDTEKWQSVRGLTVELCSGIVDRDEPFEKIAQSEVLEECGYDIPVKSLRRVTSFRNGVTLSGAMVTLFYAEVSDSQRVGPGGGLAQEGELIQVVELSVSESRKLLFDENVNREAGLLCALYWFFQHIWSERTKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBG2</accession>
    <name>A0ABM0KBG2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Relaxin receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101853139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113551.1">
        <property type="nucleotide sequence ID" value="XM_005113494.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853139"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005113551.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21567" checksum="18D9AF879E3AE8C2" modified="2025-10-08" version="1">MFVTLITLERFLVIKYPFGEYRFSTLAAYLSCLGAWCISILIAAVPFFPGHEDWALFSASSLCLAVPLDNAQHPGHIFSSVVYMGINFVMFVLLAGGQWAVYRAMSANSRTKFVGKCARKARRQEIAVARRLSVIVISNFLSFCPIAVLGLLRLLKGVEDMQRAYVWTAVLILPINSALNPLLYTLPSIKNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVD2</accession>
    <name>A0ABM0ZVD2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pleckstrin homology domain-containing family F member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101847941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935262.1">
        <property type="nucleotide sequence ID" value="XM_013079808.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847941"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15717">
        <property type="entry name" value="FYVE_PKHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01218">
        <property type="entry name" value="PH_Phafin2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051765">
        <property type="entry name" value="PH_domain-containing_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037871">
        <property type="entry name" value="PH_Phafin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280:SF3">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012935262.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30536" checksum="90524A4F8E165198" modified="2025-10-08" version="1">MVDRLVNSEANARRINNVEQCFGSSGQPLGIPGRVLVGEGVLTKMCRKKPKPRQFFLFNDALVYGNIIIHKKKYNKQHILPLEEVKLENVEDEGGLRNGWKLKSPSKSFVVFAATATEKKEWMAHIRKCVNDLLAKRGIRQSTTNDSPVWVPDSEAKTCMHCRKSEFSLVNRRHHCRHCGRVVCNACSSKRWLLPQQSSKPIRVCLTCYHKLSGEAADSNVSRTYAVIATGENRNSSGEDSSDDDDDQGRDGLPPAGQSGGLDIHDAHFQSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVG8</accession>
    <name>A0ABM0ZVG8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101854555</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C12 family. BAP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4 11"/>
    <dbReference type="RefSeq" id="XP_012935345.2">
        <property type="nucleotide sequence ID" value="XM_013079891.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854555"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF28">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045120450" description="ubiquitinyl hydrolase 1" evidence="14">
        <location>
            <begin position="23"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="UCH catalytic" evidence="15">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="266"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="392"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="11">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012935345.2"/>
        </source>
    </evidence>
    <sequence length="668" mass="71902" checksum="C85B7CE94A4E7522" modified="2025-10-08" version="1">MILSFFSPGLFTLLLEEIGVHGVQVEEIYDLQKPMEGAVYGFIFLFRWIEERRSRRKTNTEVESFVTDAEAVNKIFFAQQIIPNSCATHALLSVLLNCDNKVKLGKTLTLIKDFTENMSPEDKGFAIANMPELARVHNSFARPETSKPVPEKQSGLSSVRAMDSETFHFVSYVPIRGHLFELDGLKPHPIDHGPCEKGEAWTEKFRRVITDRLGMATGGEPYHDIRFNLMAVVPDKRQLLEQKLSTLKTNRNIVLEALQQLLDAKVVSPASSEKSDSETKSEVKKSVTFTADPSVMAAKSSTMSSDPATSLGPSTSSTTSGLPSTSSTSQLISTLPLQVVGSSKTSSSLPISILKAPASSSSSSVSLLTSSVVHSSSSSACSTSVSATSSASLSVTSGTTVTTSVGTDSSNSEDAAQMKLRSAVLSSSKVPSEISSQMSSSPSSLSGEDTIKATSSEEDNPTPTNKDLQTVKKEENATSDRDAPVKQEVMDTSNPLQNPDSEPTISIKVEVTSAVCGTNSGDPKPGAGMEVKSDVTKPLSIETKFNNSSPCAASSESTDTASEIGSGFSSPGSLNTSSCQSSPQFSDGTSGPDGEVHHHHHHRDKRKRRSSQAFTPKDLLDLLKNVENEIELCENNLKEENEKRKKYKMHKIPGQPPCIVVRLPDSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVU4</accession>
    <name>A0ABM0ZVU4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101846202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935593.1">
        <property type="nucleotide sequence ID" value="XM_013080139.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846202"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045511797" evidence="6">
        <location>
            <begin position="30"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="7">
        <location>
            <begin position="609"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012935593.1"/>
        </source>
    </evidence>
    <sequence length="744" mass="84847" checksum="01645E18B9282FC2" modified="2025-10-08" version="1">MMASEPRVQWPAVLLLLFTLSWFLHIMSGQLTNSRNQHLVSRSANTHLHWPKERFFQADRITRHDMVVEDLQQQPWRQNQGRLVKNINDKSSDLADNKAVLSSQSFETVSMSAPSKASDRLLQLQDLATPPTSKTMQRFSFVPKLVHSGTSSPSSQAQSRSYVERWFEVFHYLPEVSRTQISSLRNKRLAKPRQVDAPSGILALPQTALTKFQQKSKRIPAVLERQEPQKKGIILSRYKLQNASKFRRLRITPLRFHRSKASMKRTQWLKVSTLVGGISTWRFDHGLNSAFHSLHIFDRARKVLHPVGLWLSKKGKLNTVENGVDFRTYHNNRPVRNQGCKNVTQTFPVVNNTNAIRSEINKKLEYDFKKAFLPHSSHKPIQRTSIEHLVRQDQQTSSNSTQLSSELNLLAVQDTNKLNSLDLGSNHKQEKDLSNRTLSRLKRSSKSNNEFTSRRRPASSSEKRSSGLPFRNRFPRPPGDRDSRFPNSRPGTGDRFSNFPGLGNGPGFQPPPLGPGLGTEPQPVSLKVIVHLGVRRGYQRYIDSAITKVTRQQEFLPLIPYIRPTGRLVTLANDNPRDILQAFCTNILEANSTAVFHLINPFYHTRSWSSAQYVANLLTTLNMPVITWGPEYIGTTDKKESDTLQLTISATLQHQVQAMLAVLRHYNWKHFGVVYTPVPGHDAFLTAIRILVNDNNSNTRHSGFKFDIVVQQELSNVSDAATMRRELRDLSMTEARILLLYCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW82</accession>
    <name>A0ABM0ZW82_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetylcholine receptor subunit alpha-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101845763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935825.2">
        <property type="nucleotide sequence ID" value="XM_013080371.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845763"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="42"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012935825.2"/>
        </source>
    </evidence>
    <sequence length="258" mass="29267" checksum="D9A11AD5BE553DD1" modified="2025-10-08" version="1">MLLRRVTFRAMLGAQLAVSTVLWLALRHVHVGMAFSAEDMVRLRNDLLTNYSVGVLPLRNQSKSLPVSMSFFLIMIHNLNMKNQVLTASGWLKFEWCDEFLQWEPDSYGGIDELILFQKDVWLPDIFVENTAQHYRELGNNQMLISVKSSGMIHWEPGIITETSCAVNIGKYPFDTQNCAIRFLTWMHTNNLLALSTASVVCAGIVLNIHYRDPSHPVPRLIRILFSSSVTDTDTDTSMDRASSTDSFRLAYVDLSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWG9</accession>
    <name>A0ABM0ZWG9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101864186</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935948.1">
        <property type="nucleotide sequence ID" value="XM_013080494.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864186"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935948.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="61639" checksum="DE1E6BD1C6804B84" modified="2025-10-08" version="1">MSGTFKDRIRSLIRSGLRRQKTVSHSPPPSATRPASTLQQRISHPSSHPYCVPRSSSTSEGLQDPSTKAGCSRDPNYVFSRRHSSTLPFTQSDQNFLPPCSGRDLSHNDDDDDDADEDRNDHEDREKLSPIKTPESARYTAISPIAHFYEVYKANGGKFSKTTGAGGGNSAKLKCLTGSSMRREKSDSSEDLINCVTICSQNIPEPTFHNDVGYTETKQSDVAERKETKSEDQGSAGTVEDGNSGADQQNAADTLKDRGREGTVERCQPKEEASKKIQMCSSPKNNASKEGDLDGNDDDHGVENKGSAEESKDMMSDETGMVDVYRLQEEASVTGQLLWKGIRRYRKKTAKIAALQKYIDQLNRETAELKRLHTQANRATRALLLEGREVKNAMAAVCDVTVATIRKETQAQKLEPLCYRRYINLRTAADATNVLTAIRNRQRALSDLEVLVYRKQLVLHHSLPCQEVEKTPSKKMKSTKASKRKEQDQEPPLLPKDTRCVTLEITSAVATPVAVDQESVSWSNLVSGSDSTPTLSVALSGSNDVTGPGENEGDEQGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWJ0</accession>
    <name>A0ABM0ZWJ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Elastase-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106011326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935976.1">
        <property type="nucleotide sequence ID" value="XM_013080522.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011326"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF15">
        <property type="entry name" value="RIKEN CDNA 2210010C04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047394288" evidence="7">
        <location>
            <begin position="32"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="114"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012935976.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="26956" checksum="B42D9E7FE6BF8605" modified="2025-10-08" version="1">MMGPQAVLGGRVCVAVFLLALTLMTSAPANGKAILGNPAFGPMLNLSRLGHLSETPGVQENTLDENSDSKKTYGPTLVYRELFSEDAIPYSGVGPLVYQGSGVTDDDSGQDNFIVGGGTASISNYAYQVALLVRNNGKYYQICGAALVGKRKVLTAAHCVDQSRTYYVMMGVSDLRDSNNQYLQFIQVSRKEIHSSYRTYQDYDIAMLTLSSSARLNSRTRIVSLGFYIDTLPTKQCDLSGWGRTRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWM9</accession>
    <name>A0ABM0ZWM9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein LOC101858702</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC101858702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936038.1">
        <property type="nucleotide sequence ID" value="XM_013080584.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824749.1">
        <property type="nucleotide sequence ID" value="XM_035968856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858702"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012936038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824749.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38517" checksum="812FF6C4FFA8A3D1" modified="2025-10-08" version="1">MAEQCGSQDSDCGSFEKGDTEDHTLERLRLAAEARLTQGVYEVEVSYGGEADLHREKGRCGKNPGHKNFIPSPQFSLTHLPAGFQDKQLLETIGLCAQLTVRLVVNYTSMSRPEFLPNSKSAYPFSRFRGKTVPYRFGSGWLFDAFPRGVLGEGKGGECPCSECGQSGKPSSAWYELMFLTALHVVFDSEESKATDVELFYDSDVDRDSTVLKLAGGCVEMADIETDGCLLVCWTHDLDLGDKLQALSRQRWDLMREINMRYTREERGGLVVVVSHPHGCSKQVTVGWAVDRSDWTGLEVYRYSADTCPGSSGAGMWPVGWADPDFSILPHSKGVSKGVNECSPGVVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWP2</accession>
    <name>A0ABM0ZWP2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101846064</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101846064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936060.1">
        <property type="nucleotide sequence ID" value="XM_013080606.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846064"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012936060.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="28097" checksum="0BC0C49A4F0E54B7" modified="2025-10-08" version="1">MPRIEGKHTAASTVVGWQAQDIRRNVPFPSFRPRHTTGDMFSQIIGRHSYRKDLDLAQIYTQLSRREYHECIQKALTGIKQERTVQVRWRLSKELPSFSPDFLYLYLSRYGEVEAIYQVSVNCCLVTFANEQTLRVVVNNAHLGVPYGRLYVKLWNPKPQDNDFFRVVKHLEEASSTCRRFHAMMDTDDRKAFRGSLRHVCRLLSDNNRRHGPSIIPYLCGELKDWKKPVFGHKCWIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWW8</accession>
    <name>A0ABM0ZWW8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Metalloendopeptidase</fullName>
            <ecNumber evidence="16">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC101855633</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_012936182.1">
        <property type="nucleotide sequence ID" value="XM_013080728.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855633"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04281">
        <property type="entry name" value="ZnMc_BMP1_TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015446">
        <property type="entry name" value="BMP_1/tolloid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034036">
        <property type="entry name" value="ZnMP_TLD/BMP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF43">
        <property type="entry name" value="TOLLOID-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001199">
        <property type="entry name" value="BMP_1/tolloid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 15 16" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 15 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="21">
        <location>
            <begin position="241"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="19">
        <location>
            <begin position="444"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="19">
        <location>
            <begin position="553"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="665"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="19">
        <location>
            <begin position="708"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="821"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="19">
        <location>
            <begin position="865"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="19">
        <location>
            <begin position="978"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="306"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_012936182.1"/>
        </source>
    </evidence>
    <sequence length="1114" mass="126655" checksum="CE68C571FBF9DA8A" modified="2025-10-08" version="1">MVWTRSAAGGVHGGGAPVMWGLGLLLCSVSAALAMLMDKVPHRTSNDLYIDPCKAAGFWGDIALSDEEYRSARKMMMSRRANSSDADGLFEIQVEDPGIHSRYHYKSVAERKRQIVADRKYLRKVIKEKLAALREPCEDSSKRQCRQEKAMLREEVKKARTKLRHFKTLLRDLRGQARHSRDMTREAKLTQRHQMARKTAKSKEKKATWYTPKAKTNSTQNFWDRKRKSQSRLHHHRERRAATARKDRLWDYGVIPFMIESNFTGANKALFKLAMRHWENYTCITFKEKEPEDQHYILFTERSCGCCSFVGKRGNGAQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDQHVQIIYKNIMPGQEYNFNKLTAADVNSMGETYDFGSIMHYARNTFARNTYLDTILPQRKPGIVVRPEIGQRVRLSPGDIRQANKLYKCPSCGRTLQDSSSEFLHSPTPGRPEICRWRISATHGEKIVLNVTRLDIPQSYNCETDYLEVRDGYYIKSPLLGRFCGELIPDTLTSSGTRMWIEYRTRNGGGKGFNAAYEAICGGEITREEGFLTSPNYPDDYRPDKVCVWKITVGPDFTVALKFQSFEIENHDDCVYDYLEVRDGPSEMSPLIGNYCGYKIPEDIKSTGRHLYVKFVSDGSVQKAGFSATFVKEYNECEKEEHGCDHVCVNTLGSYRCSCRIGYELHSDGKRCEDACGGYIDQENGTITSPSYPDLYPPNKNCVWQIVAPDDHKININFTHFDLEGHNQDCEYDSVRVSSGKGKELKLHGVFCGYTFPAPVTSEGNTLRIEFNSDNSVQKTGFTATFMTDKDECAVDNGGCQHLCKNTVGSYQCACHNGFTLHDDMHGCKEGGCQFEIRSHYGVISSPNYPEYYPSRKDCVWHLTTVPGHRIRLKFRVFELEPHQECTYDHVVVFDGDDSTARSLGKFCGALVPEPVTSSGNRMFMLFFSDASVQRKGFEAEHDTVCGAHLVATAAPQSLVSHARYGDHHYDNREDCEWKIQAKEGHRIQLKFTAFDLEDEAECGYDVVTVYDGLKDTDPIRGNFCGGEIPEPITSSTEYLLIRFRSDDTINWKGFSASYQLATPPPDYVEGKDIYDLEGDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXJ4</accession>
    <name>A0ABM0ZXJ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC101855416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101855416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936554.1">
        <property type="nucleotide sequence ID" value="XM_013081100.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855416"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="10">
        <location>
            <begin position="233"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012936554.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="65017" checksum="0E45445E4D59CC34" modified="2025-10-08" version="1">MASLSTVVATQATLRPLEERMCMPGFICEHGYCVKADLECVCDQGWDGAFCRVQKVADDTFPTAATTTTVTSNDTMVEEWERLEGFPPLVPLPLRHCINGFVCRYGNCTEDGDRGYVCKCEYGFIGPFCEELCPLTCGPNSYCAVSNPSRNVSCVCDLDFIGPNCTHKSALSGVDPDLLTRSDMWVGVGVTTAVLLLVTVTVSVTAYLLWRRRNVTMMKIVFWFRDFEEDDGREYDAFVSYASTDWDRHFVIQTLMPRLEGRLCFSLCIHQRNFEPGLYITENITESVKRSRRTLLVITPAFISSTWCRFEYQVALKEMLDEKHRILPIVIGDVTEHKKKMDETLKTILGTVTWLEYPGHDASQRDLDKFWKRLALSMPKKRPAQSEDPSSPTSSTSQNSNDGSIGQLVTSKPPSPTTSAGEIADNDPKISPGPIIKVPFPSENGKDVEYKQIVRVPASELKDNVQPGRSLCPFSTGWFRKAPPKDKISRTKQMKPPLSGNSKKQDQLQSFTHFGFESEVDGGCGVSRYAVQKGLSDQNGVSSSANDGQRLRQAPIHREQEALFALTDNFLGDQSIHRQLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYR9</accession>
    <name>A0ABM0ZYR9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101855185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012937309.1">
        <property type="nucleotide sequence ID" value="XM_013081855.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855185"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF46">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="181"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="771"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="896"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="658"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="845"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012937309.1"/>
        </source>
    </evidence>
    <sequence length="1238" mass="142308" checksum="9B66757F26DE6EAF" modified="2025-10-08" version="1">MPGKALKKKDLYLGKCMDDLHKLSEVKPLGNNVNIIIRSAAKVFKDAESFDGQNDEERSFVMYIKYFNILKQVKSKPDYKKQKDYFDNLIGKKNQLTAIERAEVLADSLKERYDLKEAEAVAKKLASLDTNSDAKNGGEEKKNEITAAPEVKENGKPAESEPAPTPGLIKCTDLCKLLRDSEVQLILMDVRPASDFAQSHISHTDCISVPEEIIVPGSTVNRMQGNLPSESKEVWMKRKHADHIILFDWKSTLNSVTVGTPLKTLKDALFKFDTSTIIKSEPLVLEGGYEQWLLFYPTMTTNAHVVKPSDLHREKNPSPTATLDFDYPELDENLQKIVPSKGKLQPDSMPTDQSTHIDNGAPLANETHPPSSAQPAAPKFDRTLKPSRSGELALNNTTALPRQGTLSPSSSSEFTSGGELNNSSQSSKANTSSSLSSGLYPRVLYEKNSDMKVNNKNINILNNDLSRNDLKSSNLDVDLKESMLQRGKKETELRDFQQQKDKTLREDDQRLREAEQKLKNLEEMRKKEQKDVADLMRMKRKLTEEIDVEKRRQEEDQQRLAEEEVTRTQALEAARQEEEEKRQRMREVEKLREERKKNEQQKEEERMQQEEEQRKQLAATREAKLQTEQLEREREMEEKEEEKKRILDEVEAKRLERLRVEEEQKKAEDAIQEKLRRQKEAEEVARQEVEREAAERRQREQERQRKEREAREKREIEERARERERKRKEQEDRQREEERKKKEELQRDEKAKIAGQIAGATNGQSKSVPSTYLPKGWEKRLDFSTNRYFYIDHNKGLTQWTPPSMPADMKGASVYTTQLKDEPSVSSSRGLSRSHSSPNIMKELADEEKARRALPGVDRGSKPSISNSQGLSKQIVYQKKAPDLNPVYGNVGPALTGLRNLGNTCYMNSTVQCLNNTTPLVTYFVNDYHLADVNRENSQGMHGEVVDDFAAVIKALWSQQYRSITPRDLKNTVGKYNPMFAGYQQQDSQEFLTFLLDGLHEGLNEVKKAPQIPEQNNENLPDHQAAETAWKHHRMLHRSVIVELFQGQLKSTLMCRTCRKTSVTFQAFMFLSLPIPASNRCSLKECIREFLKPEMMTGSSKWKCPRCKVERDSEKKIDIWKLPPILLIGLNRFYSEGMWMQKKTTYVDFPTQELDLSDAVIGPKPRKAFNLYGVSNHYGTMEGGHYTACCRNPVNKKWHKFDDQDVYEISASDVKTSAAFVLYYSSIELQEPKYKMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZD7</accession>
    <name>A0ABM0ZZD7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101858181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the large ribosomal subunit. May bind IPO9 with low affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937659.1">
        <property type="nucleotide sequence ID" value="XM_013082205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858181"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012937659.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24251" checksum="A0C60CE278C9D233" modified="2025-10-08" version="1">MPSPKPAQEFVTKKIGGDKNGGERKVRVKRLPRFYPTEDKPRKLKNYQKSFSQHKRRLRASITPGTVLILLAGRHKGKRVVFLRQLNSGLLLVTGPYHLNGCPLRRINQKYVIATKTKLDIKGVKVPDRVNDEYFRRQKLRKPKHTEGDIFNTKKEVYSVSDERKEDQTAVDRQVLDVIRKLPEKKLLFGYLGALFSLSNNQFPHKMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZR6</accession>
    <name>A0ABM0ZZR6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 50-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106011746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937889.1">
        <property type="nucleotide sequence ID" value="XM_013082435.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011746"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="291"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="723"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="757"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="790"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="824"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012937889.1"/>
        </source>
    </evidence>
    <sequence length="1088" mass="119509" checksum="3C75BE927BC53561" modified="2025-10-08" version="1">MGKQSFQGAPSQCQKKDDHIPPGRRSMRTASKASSQNAQSHTGGEDTLGASVRVGRRSLQGTVSSSKCYKKGQKPTTQNTRNGGHRSSLASTRKRKKSCRSSDSETPAKRQRKSKCDKTVESVSSCTSSQDKPSHSCQKKNQRSNPNSSSWFTKLSQSLLKAVEAGRSIKVTEILKSHGKCLLSVLDVALLKAVSRGHLFMVQNLIHHGASLHTEIFGKTCFHTAAENGHIDIMEFLLEKSDGRHFFMNDARDRGGNTALILCQGTPSAAHITKILLPHSNEPAINVQNRKGETALMKAVQSQNISAVLQLIKAGANVDLKDKKGNTARSLATALGMDGLLEVLAKDTSGQGLTPIMIAVRAQNTDLLELLLLSKQFNVDEKAVETDEIGDVHFTDTALTMIFNSKLDKKEDLLTYYIDWKTCLHSFEQLTVKEQDIVAMLVKDGANIHIGGKYDYYYISPFLMAVELGDGQLLDLLLKNQKWIGNVDSYAKALEVAARNGRCDLIDALTPWVESLEHHFDLKQEWNCTFQDALNNALKVANEECVGKLLKIIKNIDFNKTMTAAVESGCYPVFLRVRNAYPEKFHQFVSRDEGAKWLCAACKNNNSAIVESLLNSGAKATGSDLYYVPLECSKSADITEMLILNGADVNKHHCSYINGHLTNTALEQAVLSNLTEVVKVLMKHGATLHIKTLNLALSRSQCLGEMRKVLLCFDVNLNQTGPGGQSPLSISAFHGDLESVETLIKKGADVNFKGRRYSCPALISAIKGKNVEITRYLLDHGADVNISNSKGETALTMAARTDDGTIVPLLIEKGAWLNVSNSCNNLTALMVAAKYKNFATFQCLVEAGVDLDVRRNGKTFLTRLLLKRSYFVMSRFIVCLVKHGAKVTSGDAMLAVHNCIALGNFHVLSALIHCGGFNPTLFKDIQIEKTPPFCRAKVTLIVDFTGVFSPLCMALLCGHVTVARDMLKASYLTTSDLTLLPIHTKVREFLNKRGFDESVAVLDEMSVSVPSLQQLCFVHVSDMCGSEPGRKETVRQLGLPGRIERSLLFSCNDQLVGGKCCMAENSSETTPAEVDETSDRYIYRGFMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1T5</accession>
    <name>A0ABM1A1T5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Argininosuccinate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC101857188</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100441.1">
        <property type="nucleotide sequence ID" value="XM_005100384.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005100442.1">
        <property type="nucleotide sequence ID" value="XM_005100385.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939094.1">
        <property type="nucleotide sequence ID" value="XM_013083640.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857188"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="3">
        <location>
            <begin position="368"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005100441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005100442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012939094.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="52585" checksum="AF354057FFA2A54E" modified="2025-10-08" version="1">MAEKGNKLWGGRFTGTVDPIMEKFNASIHYDKRMWKADIEGSQAYVLALEKAKLVTAEEREDIYEGLEKVKHEWEAGTFEIRPGDEDIHTANERRLKELIGSAGGKLHTGRSRNDQVAMDMRLWMTDAVKTLTRHICELVRVMVSRAEVEIDVLMPGYTHLQRAQPIRWSHWILSYAAMLQRDVQRLDQLRDRSSTLVLGSGALAGNPFDVDREFLRSELHLERISLNSLDAVSDRDFVAEFLFWASLLGVHLSRWAEDLVLYSSKEFSFVTLSDAYSTGSSLMPQKKNSDSLELIRGRAGRLYGRCTAFMMTLKGTPSTYNKDLQEDKEAMFESYDTLVAILQVATGVLSTLQIHKENMSKALSPDMLATDIAYYLVRKGLPFREAHGMAGLCVALAEKNGVQVSQLSHKDFHSVSPLFDEDITQVWDYNTSVEQYKAQGGTARPSVEGQITKLRTWLEETACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2L1</accession>
    <name>A0ABM1A2L1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prion-like-(Q/N-rich) domain-bearing protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939580.2">
        <property type="nucleotide sequence ID" value="XM_013084126.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012142"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0034">Amyloid</keyword>
    <keyword evidence="3" id="KW-0640">Prion</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046608585" evidence="1">
        <location>
            <begin position="29"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939580.2"/>
        </source>
    </evidence>
    <sequence length="250" mass="26398" checksum="4F30D87A1D021D7B" modified="2025-10-08" version="1">MSPFTQVMGGGTLSVMFLFCVSLFAAEAAATASTPTQTNPTTATPEIQFNETCTENAVCTENLQCDDLTSKCLCNSSLYYNDSLCVERIGYNQGCTTGTVGSCAEDLQCIGSVCKCQDTQYHSGSNQCSPKIGYNGQCTLGPQGSENPCAGDLSCVNFVCKCSDTEYHSGNNLCATKIDHGDVCFNGNNESCKGDLECVTSGVEYQCVCPAGKYHFENNQCRDKIDYGGGCAVSDSCNGNLQCVSSVGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3H8</accession>
    <name>A0ABM1A3H8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940082.1">
        <property type="nucleotide sequence ID" value="XM_013084628.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012255"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046883403" evidence="1">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940082.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21396" checksum="5577BDCF7E854DEB" modified="2025-10-08" version="1">MFAIFLAFASLLAAPAPSQAQSPYGCDRLYESCTSDPLWLGPWILGHLHEEKVYDHFCSDAESYMSTVSCYRGVSKFCDPGNENHLPTVSNTYFVHQDHCENPNVNRTSVMEAAKDQETRYCVSAANIALTTQRTIAPNATEAQRNMWECDNHNDRIDCYMTTLKKLDETTWGNLSKIAEKALPEICLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3M5</accession>
    <name>A0ABM1A3M5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012278</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940161.1">
        <property type="nucleotide sequence ID" value="XM_013084707.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012278"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940161.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="54015" checksum="7520A51308683A75" modified="2025-10-08" version="1">MRKGCVGMECTRAGRQCSGITETDRREIFQDFYKLADLQKEREFVARHIETTEPKVGKPNSRRSKTHAYYLTVNGKRLKVCRNTFLATLSISEKFVRVVLSKITETGVVEEDKRGGRQSEQMKTREEQNRDKISRHIDRFSRVESHYCRASSSKEYLSPDLTLSKMYDMYVKENSCNDIPSFHTYRRVFKTKSLAFHSPKKDQCSLCNSFRKGDEAQKNELREIYNRHEAEKQKVRQLKEDCKKMAQADHSILAGNFDLQQVIYLPISHEDALFYKRRLSNFNLTFYNLGDHTCDCFIWHEGQSRRGSSEISTAVCRALREYDQRGIKTAYLFADGCPGQNKNTIMPTMMLHMINTSAHMEELSLRYFESFHGQCEGDSAHSAISTALGNAGDVFLPSQLFPIIALARRKQPYKVHPLEHGDFLNYKKLSEDLKVLNVRKDNQDSGVPVNWNKVMEVRVNKAHPTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A485</accession>
    <name>A0ABM1A485_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EKC/KEOPS complex subunit TPRKB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101857162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940519.1">
        <property type="nucleotide sequence ID" value="XM_013085065.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857162"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011465">
        <property type="entry name" value="PRK14886.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012940519.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19806" checksum="1BA5A196F7574F34" modified="2025-10-08" version="1">MAAYIKVPHTLYPDKTITVALYRNVSCKELRKSVMSGAIEVSLLKTSMVIDEFQVLVAANKALHLQHAGTMMTKNVHSEILFCLSPSKNISESFQSFGAADSDTNVVVAIADDQDDERLDKVSEILGKSPVALTELSELADTKLITKAYKVSADELNSYDLRDAVVSRISAKEIITAGKGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4J4</accession>
    <name>A0ABM1A4J4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101858200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940708.1">
        <property type="nucleotide sequence ID" value="XM_013085254.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858200"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046292827" evidence="1">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940708.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="49904" checksum="AB3A1D908AEF5E98" modified="2025-10-08" version="1">MKLKVLLLLAGFAVFAESACPGCDTAETLKVTVGSLDFQKDCTAYKTAYDCNAKCPDVQKAMTSDMADICVSGTDTLSPCGMKVADCVTDLRKVETASKENNKKLVCSDVAKFFKCAGIALDECKSQNDTRFIDRLKANLDEVDMEEGCGGECAASVGKCLKNLSADLSNIQDTTKFKDMCKNLAAVEPCITPLKKTTCASTPTNLKAADSLLQAGRTQLSDFCAADGTPSQCVIGYGKCGDKVKAALQTTDTTTQCSDLSSFLTCAERLPCKNSIEDDIKKQIQSIDSNEIKSNCPTIGGCVDRLDNCTKLLEKLKKVTPADSQFCTISKQIEACFVVVEKDPSCKLENLKVDSTEQKFFDLYGTTCGNGTLCYGGLTECYGDIKGVSQVTNKKDCDLFGRAVTCIDSLLKSDICRKVQGKLRSQDNHLKSSYHSTCDDGVMLQASLLLTVFAALASYLKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5U9</accession>
    <name>A0ABM1A5U9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier organic anion transporter family member 2A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101850586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941408.1">
        <property type="nucleotide sequence ID" value="XM_013085954.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850586"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF157">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="519"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012941408.1"/>
        </source>
    </evidence>
    <sequence length="725" mass="79296" checksum="7BDC25E9D59FDE6F" modified="2025-10-08" version="1">MSDQQAHDNGGYVNDPKDNSLKIKALPVAPPLDEEDDEVDLSFGIGPFRSKLLGKCFSNMYVFVVCAGLAGMVSRMGPTTISGHMMGLKAQYNLNDGQIADFPMMNNVGTVITTLAIAHFGKKSHIPFIIGLCAFTNGLLLMIPAFVHFAKPYHLPGKEAADPQQMMMMLMTQMCVPPTNGSGSIPMMPPRDDDRLGYDLFMTVMTLSGMVTPSFFVLPPIFIDNNTVKKARTGILMGITTVLMEISVPVGLFINRATVKEPVDLKDTSLDPKDPRFVGAWWIPLLIFGVLGVTIGIPMMLFPRHLISPKRQKMALEKAKIAFVGGEKTDTGMASNGNGKLNGDSPPTYQETNGERRNSLYPPAATTTERRASLIGDVVYSQPVEKEGASLAELLKEVPSTMLRLLKNPFFVLTIFFILMVTIIMRGAETFRFTYPVYEYDYDLEDALLFSSLSVGIGMISGTFFSGFLSSRTKSKGGLVLIMVFAYLAAAAITPVVLAFPCDTVKFHGLDDAKYGIPVNGSDVCSCQNGFIAPVCGADGNTYYSPCYAGCTGRTPDMMGYVNCSLLENFDKGDTAANLPCPRNCENGFWAFIVIMGLGIFAFQASLIPAELLIIRSVEPRDRSFGIGCLFFAMILLAIPAPKMFGSMYDNLGCIAKIGNICVGYDREIIRYILTGMDTSAYGGAFLVVCTMYLVTKYQDRKERKKKARKQLSVMTPPSVNVYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7A0</accession>
    <name>A0ABM1A7A0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Post-GPI attachment to proteins factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101851599</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105999.1">
        <property type="nucleotide sequence ID" value="XM_005105942.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012942220.1">
        <property type="nucleotide sequence ID" value="XM_013086766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851599"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22190">
        <property type="entry name" value="PGAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005105999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942220.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="48605" checksum="7C890ACA4AC6F939" modified="2025-10-08" version="1">MVRLALRRNHLLALSGFFLVLLLLCYRLPFSQLYRKMHNYNTLFKQVQEASRLRSHVSQKYFQSLERTPKPNIYQERMKKGNVTIAVGLITVKRSNKETEHLPPGTLDYLMQSASLVDHIMRHHAFFQTSVPFICNVDTFPESHKTAEKLYKFLPYTERYGLNSFGIGPLTFPGSKKLYQDVQSHVSRYHKETYDYAFCLQSAASLHPQYVILLEDDVLPHKDLPYVLEHMIHSRLNLTKSDHYKNGIAYLKMYYPAKWQGYATEWTRVFDLLSVSAVGAAVVLLISFILPAKLKSKIMCNESWKTFLISFLMVMLTCWLLGRQNINEFRRISKHLYRLQQSEGCCTQAMLYPIDVVAPLTQHLVTVSPHTHTDLAIMDYAAQGTLPALQIEPSLFFHVGLITSLNQRQKHPEEFIFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7K0</accession>
    <name>A0ABM1A7K0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DPH4 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DPH4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942370.1">
        <property type="nucleotide sequence ID" value="XM_013086916.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860681"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="7">
        <location>
            <begin position="105"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012942370.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18966" checksum="E773560642466185" modified="2025-10-08" version="1">MENLYEILQSSPQASAEELKKSYMRLARQYHPDKMSHSRSNGQESLSEPSRCEASNEQSENTFQKNCSDEFVKIDRAWKILRDSELRTQFDLKWQERCLSQDLPIQDTVPYEDFDWDDSEDMYTYPCRCGSFYLLSETDVKLLYDIVCCETCSLTIKVVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8S2</accession>
    <name>A0ABM1A8S2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTPase IMAP family member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106013000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943010.1">
        <property type="nucleotide sequence ID" value="XM_013087556.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013000"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF184">
        <property type="entry name" value="GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012943010.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21782" checksum="B0DF350994F3E12D" modified="2025-10-08" version="1">MFKLGKRPQPPLMPNGNKKFKFGPIQWNLMMIGKTGHGKSSTGNSILGRTAFVVSDSSESETDAVQVAFTSLSADRGSVKVADTPGIGDTRMDTVTAIRKACKDLESGIQKCPGGVHAFLLVLKYGNRFTEEESRTVRSLKSLLGEDVLRRHCVIVFTHGELFDLSRKKGPGNSGDFSSWCCEQTGGLGDLIEECQHRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9D9</accession>
    <name>A0ABM1A9D9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101862530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943338.1">
        <property type="nucleotide sequence ID" value="XM_013087884.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862530"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012943338.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="52071" checksum="A9CEB40EBA6ED9BF" modified="2025-10-08" version="1">MAFLGFVNVYCLRVNLSVALVAMVNSTSDSNTTNSNECPDPDGGNSSSSSNMGEFNWDEETQGYVLGAFFYGYIVTQLPGGWLASKIGGKNLFGYGVLCTSLLTLVTPVAARYSVYLFIAVRVLEGIGEGVTFPAMHAIWGNWAPVWERSKLAAFTYAGAQLGTVVSLPISGVLCDSDVAGGWPSVFYVFGAIGCLWFIAWMLVVHNTPADHPRISASEREYIESSIGKKEKVDTPWRHILTTPAVWGMAVAHFSNNWGFYTLLTCLPSYMKNILKFNMKENGLLSAVPYLVCWLMQNASGLTADYLRSHGHLSTQNTRKLFNSLGLVLPGGLLIVVGYVGCDHVLAMVFLTLSVGFGGCTMGGYNVNHLDVAPKFAGVLMGITNAIATIPGFVGPAIVGYLTNNDQRRSQWQIVFYITAAVYVFGTIVYLIFARGEEMWWSRAPPKRQDQRPPLSRENSEETQSVNSDPPPAYSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA78</accession>
    <name>A0ABM1AA78_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Inositol oxygenase</fullName>
            <ecNumber evidence="4 12">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101859737</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 12"/>
    <dbReference type="RefSeq" id="XP_012943819.1">
        <property type="nucleotide sequence ID" value="XM_013088365.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859737"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012943819.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41527" checksum="5724C547D594329C" modified="2025-10-08" version="1">MTTVCTNMKILLFEGHFDKAMACPGLLDNSTEILIKVGLVTLAGNRGGLICVGFGNLKLILLLILKKTQGRKSDTTTMATTVSRPAKIVLEDPSEFRPENQDASAFRDFRVHNVPDRVRKTYDLMHTNQTVDFVKGRMSHWLQLDHGEMTVMDILEELNALVDESDPDIDLPNIYHAFQTAEAIRKHHPDKPWFQLTGLIHDIGKIMHIWGEPQWATVGDTFVVGCAPDPSIVFGVESFANNPDLKDPRYNTTLGMYEANTGLDNVLMSWGHDEYLYRVLLGNKHSLPEEALYMIRFHSFYPWHSCGAYTQLTNDKDNSMLRWIREFNKFDLYTKAPDMPDIEELKPYYQGLIDKYLPGKIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABC6</accession>
    <name>A0ABM1ABC6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arylsulfatase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101848696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944441.2">
        <property type="nucleotide sequence ID" value="XM_013088987.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848696"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046607207" evidence="7">
        <location>
            <begin position="23"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012944441.2"/>
        </source>
    </evidence>
    <sequence length="500" mass="56938" checksum="D54FDB5B8E562FEC" modified="2025-10-08" version="1">MTMSRLSLCALVLSLCYDMTLGKPPHIVFIVADDFGWNDVGFNNPDIISPNIDALALNGIILNQSYVQPVCSPSRSAFMTGYYPFRMGLQHMVIWAQVPVCVPLNKTFLPEVMRSHGYATHAMGKWHLGMCNWKCTPTYRGFDSFFGYYGSREDYYSKINMKYFDFRNNTDVFLNAKGTYSTYQYTEAVQRLIASHNATRPLFLYFPFQSVHEPIMVPKHYTDLYPNVTSEGRRIFSGMVTAMDDTIGALVQALKDKEMYEDTVFFFTSDNGGWPARHGNNFPLRGSKITIWEGGTRVPAFIHSQKFVQKGVRFNGLMHAVDWFPTILQAAGIDYHDSNWDGLGQWQAIRLLSASPRSEFVYNLDNSTHPTQGRAAIRVGDFKLIEGFPGPYSDWYLPGQQGQGQNDASCATFDRADDLGCWQDGPEQMGKNWTLFKGLFNLRNDPYERENLYEARPDIVSQLRARMSYHYARMVPANYPPADPRGDPARWGGVWSPGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACR7</accession>
    <name>A0ABM1ACR7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein heavy chain 6, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945205.1">
        <property type="nucleotide sequence ID" value="XM_013089751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858903"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="1">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945205.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18355" checksum="7113285D6CF361D5" modified="2025-10-08" version="1">MVGLGERRVTVYGRSRRERVIVYDRSRREKGKVIFFNLRDLSKCVQGMLQADPGVIRDRLQIFRLFVHETQRVFHDRLINSEDKMFFHQIMAEMASKHFGETVEPDSFVTSPVLFGNFIKMVFSVVSQACRSMVMWVRAMDLYAKVFRTVEPKRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADQ7</accession>
    <name>A0ABM1ADQ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106013735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106013735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945728.1">
        <property type="nucleotide sequence ID" value="XM_013090274.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013735"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945728.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="65350" checksum="72A5647DF08DCC58" modified="2025-10-08" version="1">MSRELQNQLLESLRQENKGLRELLSVISRQFEEVSHAQKEGRQILDSLVGEKYVESLGFMTCEHWRDMLPAIACKVDGIRRCFRDGGSVESDFHYIEPFGYFVKAQVLFQGDSFNLFVIMDVGKFDDFLPWPAMVECVMKGVRPDGEEVEVGVRSGEYSRPTEEKGASVVAWNMTVGRQFLEEHQLIKHDSACFKWVLNVISRRGSRRVVAGTGVASGGQCAPNASSEAENYFQTEACTCKSPREIPTAPPPETPCRGYTQVVTGDLGNVAGDVTGGVVDNVEGHTADSVAGDVTGDTAGNVVDDTAGNMCARDDATAAAPGESLGDTEHVSEREESEEEGGAGHGGNDNAPNTGVGDGEVYVGGDGTEVVLAGTEDGEVYVGGDGTEIPVVMAGTEGGERTGHRQQRRKWTTLFRFLCVMLFCVSMCPGFTFVATARVCSYTAGVCRQVWDSQFILGTTFNNSSKANMCLWADEWKCLPEDETTGYGELLAWVQNPPRVWNTALLAWLQNYPLRFFLPLMANGVSANGVDGYVLENMGLMSTETSMAVHDFFLRLQRRGKELEEGKKGQTSSSQRKRHRQPQKQHNEGPEMSHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VNS8</accession>
    <name>A0ABM1VNS8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium/calmodulin-dependent protein kinase type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824070.1">
        <property type="nucleotide sequence ID" value="XM_035968177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477224"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824070.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18451" checksum="12CD81D2AB7DDF7E" modified="2025-10-08" version="1">MPLFGKKNEADKKLKESDIRRKYEFKDTLGTGAFSEVVLAENKLERGKYNAVKCINRRGLRGKEEALENEISVLRRLSHPNIVRLVDVFEDKTHVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQVLEAVDYMHDRGVVHRDLKPENLLFYSPADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VP30</accession>
    <name>A0ABM1VP30_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen alpha-1(XII) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118477245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824172.1">
        <property type="nucleotide sequence ID" value="XM_035968279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477245"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01472">
        <property type="entry name" value="vWA_collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824172.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20865" checksum="D02749A5CEC91FFD" modified="2025-10-08" version="1">MSSSIFILDFMKQLTFVSNLIKLFDIGRHKTRVAAVSFSTNATVEFHLDEYYDQKDVRDHVETIRYTGGVTNTDDALNLVKNSVLTSEHGVRSNVLHVVIVITDGRSQNSPDTRTKAKALKDSGIFMFAIGVGPYVDDQELEDIASAPSENFMFTIADYDALLSIKNTLALRVCKAGRPGSQRQIDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VS68</accession>
    <name>A0ABM1VS68_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polycystic kidney disease protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106011567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825260.1">
        <property type="nucleotide sequence ID" value="XM_035969367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011567"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF197">
        <property type="entry name" value="POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin" evidence="9">
        <location>
            <begin position="170"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="8">
        <location>
            <begin position="385"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035825260.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="57453" checksum="6080E6327A89C19C" modified="2025-10-08" version="1">MTLIPPPRPVSHGKDAAENPMGISRDLIPPDPVPEDVIEKMREQKKEQQQANGILVELILYIIFIFCLFSVSYSNRDVRSFQLQDHVLESVYRVPKRRENSQVSDYPLPWNKLRTHQDIYTWLNTTMVLRMFPSKFVSGKELTPEGRQFMEDLANYRVGPVRMRQLRTHQDIYTWLNTTMVLRMFPSKFVSGKELTPEGRQFMEDLANYRVGPVRMRQVRMPPIPTPEIHTNRMTGPGLSNEGNLVGDKQFYPTYDISSEETGTYCLAWRPLPCSLDEQFKSTLDENAIPVVGKLNVYSGGGYITDLSGNRDVIKENFISELFSNRWLDLQTRAVFVEFSLYNVNVNLLASIRLAAEFPVYGSANTWIDIRILRIYPHIGPLGVYILLCDIILVITTFVFTFKVFKGIARERWSFIMSWWGGIDLLMVLISLNAIIFFIIRTVHSSQVLGRFRGNPKAFVNFYALIIYDDVFGWLLACLVFLSTLRIMRILGYNQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSW3</accession>
    <name>A0ABM1VSW3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho GTPase-activating protein 35 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825505.1">
        <property type="nucleotide sequence ID" value="XM_035969612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860974"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22207">
        <property type="entry name" value="pseudoGTPaseD_p190RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057284">
        <property type="entry name" value="FF_RHG35_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039007">
        <property type="entry name" value="pG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051978">
        <property type="entry name" value="Rho-GAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032835">
        <property type="entry name" value="RhoGAP-FF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045786">
        <property type="entry name" value="RhoGAP_pG1_pG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039006">
        <property type="entry name" value="RhoGAP_pG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23083">
        <property type="entry name" value="FF_RHG35_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16512">
        <property type="entry name" value="RhoGAP-FF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19518">
        <property type="entry name" value="RhoGAP_pG1_pG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51852">
        <property type="entry name" value="PG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51853">
        <property type="entry name" value="PG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="489"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="PG1 pseudoGTPase" evidence="6">
        <location>
            <begin position="595"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="PG2 pseudoGTPase" evidence="7">
        <location>
            <begin position="781"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="1521"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="977"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1147"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1285"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1448"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1148"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1223"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1286"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1318"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1381"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1476"/>
            <end position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825505.1"/>
        </source>
    </evidence>
    <sequence length="1723" mass="194268" checksum="E104AF098994AC01" modified="2025-10-08" version="1">MARRAEGRTFNVSVIGLSGTERDKGQYGVGKSCLCNRFFNQVADNYYQEHISVLSQSDFAGRVINNDHFLYWGSVTKTDEGNNFTFHVIEQTEFIDDVSFSPFKTARTETYLKRAVGGKVQSAEKLMYICKDQLGMETDSAYPQVLMPEGKLTIDGFLCCFDVSKVPQRSIEKQVEFVASLLNNALKTKKPVILATTKGDSSCQEYVREAEKLTNRKEFKGNVPLVETSAHENINIEAAFLLLAHLMDKTKARTKLLPFLDARKQRHEFLAVAKDAYLSLLRSTVRDPKAVWNTWKKKLEVESDFGHYVEMFGTEQARKEFRAHTKRLRDEQIRSKEQRYLEKLPVLLKTFLPSLESIPERSWNTLRRLICEHEEFESNFVVVEEDGVTSWKQVESFLDNTEETRIPFDLLNSAEAEMCFRNHLNELQALHRKRELQLQFKKVLEENPQVTPGKPLSETYVFFLGKECFSSLDEMERSQVYEQHLGELRAAARAQFQELLWEKSHVFMVWNTAERLTQKDLQSITAALQDDPRYKALHRLEEDRKVTILNHLGFIQSPSRGRCSFGSFCIDTQVENLLGERAIRPELKSSSDSVDSGSKTLNLVLLGKDGLAIALNREIRTLCTDDEYRLESTTYSLDYRPIDGDVSREQNALATANFKPHGCLCVYNSEETLNYVKDSLERSLTNDVVKEGEATLSGMPIAIIQASNSSQSEKENERLSEKGRSIAARYHGEFIVDSEEVEEGVLFVEEQIHSALQMVIRGCSPGLSSWYLSDQFEPDIRLSMCLMCGDPFPLELPLGPLLNHDMCRVLADTPYCITLDLFLELAKQKVEVEVASYHGGNRLHQGLFHGHILVYSAKRKASLATLRAYSETLLGVPKLILAVADSGGASSSFFSSEVCQELIQEGNQLADTLGAAFMTTTANFPQQTAVFLPFFTSVWLQREDSELLFHEPSEEPCPPAYDEKAYYASRPPAPLPKQYAYHHTHKSSTSNSTDSEPVYDQPNLFHSRYSDSDHEADRGSSVSPPPGANEEIYSEVIIPNGEHLVKPSVVKARKNVYAGTSKWEHRKSLPIMPSAVSMSLDAGSMMGSTSSSGNNTMGATTTSSSGSGSFCNNSLPLAELSQPVRGRAMKDPQEFFRKSCSMKIAAEEAVEAGDEAEEEEEEEEDEESKENRLKGARGWLDISSASGKGEAFGPSRYGTSQSSHDIHWSQNDAESVSRRKAMSSRSQSQSAAMFRSHPGQVTAPLAKPEPIEIADYCHVKDAVPLLPLGDHDYQIVEDALPPGQLHRIRSTKSPIRVKGRTDSEDSEFSSLEREQMQKSRRSTPHRRKSKPRHQDNSAIYASPMPSSGKHRYFAFGAKENKGRSHSPSEGSDGTGDELLAMKKKGKKRRSFNHRKWRTPLSAQGHRASSPSMLSDEVQLLSSSQVHSLEDMSYYNPVVHHFQTLPKNVGTSSGAGEEAEFDPNDSNNWSNRFLFKTMKDPEKQRKKDERRKQKEEEKRAKEAQKRTKKKESKSSVTSTSGLPLEDYPTSQENRSIPHFVYKCVSYIEAEGLKTEGLYRIPGNKAQGELFLSQYAADPNVDISTLEIPVNAIATLLKSFFSDLSEALIPSALCDELLEAAVVVKKTEMTDKSSRLLMLRGVIKKLPNQNVEVLKFVISHLYKVSEHQEYNSMNSGNLAKCWWPTLIRLQFKTYEKMVQYSQVPEDIVQTLIEQCYFFFYGGNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT16</accession>
    <name>A0ABM1VT16_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cartilage matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825558.1">
        <property type="nucleotide sequence ID" value="XM_035969665.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859934"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF87">
        <property type="entry name" value="COLLAGEN ALPHA-1(VI) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="201"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825558.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="42679" checksum="827A59FA6871E38C" modified="2025-10-08" version="1">MFLLEDSRNIQSTSFREMISFVKGLVAQFDISAAGTKVALATFGKKLNTEFDFGAYNSLAEVEHALDYVHLENGDETNIGKAISYAHSTLISHQRPGVPHKLIIIINGASSDQKEASKAAYLAREDGVEIIVIGIGSQNNTQLQDMASKPASNYLFPVTEFPKLSSIGDQVKQKTCPGAGPTDTPTDQSTAEQECQLRPAEVVFVLDESSSIFIPDFLKQLAFVSNLINLFNIGKDKTRVAVVSFSTNATVDFHLDEYDEKSELKERIGKIRYTGGSTNTGDALKLVNDSVLTSEHGIRSDVRHVVIVITDGRSENYIDTQVQAEALKDSGALVFAIGVGSYVDDLELQGIASTPSDHYLFKTTGYDALPSIKDTLAIRACGQTIQQTIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VU14</accession>
    <name>A0ABM1VU14_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477765</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825906.1">
        <property type="nucleotide sequence ID" value="XM_035970013.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477765"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035825906.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33023" checksum="66487008603F9105" modified="2025-10-08" version="1">MAAGNYRPSLSSNGTVLRCAFEDSNSSLSEHGLVDERELLVIRAVISEARDGVLNQGLAAITCSVIHVPDWSTISIQRVTSPSSSQDVLTVGRDGSTTWYDESMRMRAVPEFRRSDLESVVTLWLSSSRCGDQGTYTCVVEGSGVRRRSHTKLRVFAPPAHPSLSLPSLILQDSKAQLDISCDVTNLGRPRATMTLERKLPHETGFTSLTFDDVTRVENGACMTSARGIYKTLVSRDLNGTIYRCVVRPAPGSGHLFEPTWAEETLSLIPGDICESRGATLLPHPSQCRHFLQCSPGSAAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUL5</accession>
    <name>A0ABM1VUL5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein LOC101860416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC101860416</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826107.1">
        <property type="nucleotide sequence ID" value="XM_035970214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860416"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="932"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="973"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1003"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1193"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="19">
        <location>
            <begin position="807"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="820"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="17">
        <location>
            <begin position="826"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="449"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1296"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="463"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1296"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1331"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1382"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1399"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1420"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1431"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1473"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1516"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1558"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1582"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1593"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1609"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1642"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1660"/>
            <end position="1675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035826107.1"/>
        </source>
    </evidence>
    <sequence length="1692" mass="186695" checksum="61ADE214A29793D2" modified="2025-10-08" version="1">MSVSGLLQPAPALPVGQSPGALGPPYSPNLINLSQQYNMSGNTLTDALLLLSGMYISLVQPSPGPVDVGLHAFFPLTTSGDFIAAVGDAFKPLKIGWTHRKYPALAQAFNANSTTSRSFYSPKDFLNILCTDIFPQNTITVFYLNNHLVIEQYDKPASDYIPRIIESLGLPIISYDTEFSVNKRPALSIQLAPTMGQMTDVMFAFLRKFKWTDFSFLCTLSYGCMDEIAAIRAKVEESKSRTNLSVYGVDMFSYNLLSYVNFTNGRDREEVEEKLRYELDKDTRIILVHGRYGEVATITDIAKELGLTGHEYVWIYTHASISLKKENSIVGRSYPLGSFILGYDNKREDIQAVSKMAVDLWLDTLNRMAMSPDMQDMDFKTGFSCDRLQAQLEEEDEGAAKKPLFWKYGEKLYKKLLEAKLPGGLEFDKYGVLKANRFWIKNVQLKETRGRSSSRGRIGGGASRTSSRFSRPSSSSRTSSGFLNRRPSTGGSTDRSRGSGYSFSRNRGGSAGNTTSGDRSSSSSSSRNRFSSRNSTSGDRGSGSPFSRDRNRSSGSPFSRNRDRTSPFGSDRNRASGSPFSRGRDRASGSSFSSGRSRSSQSPYSRDRNSNLDGRGDEEDSEDDDDSTAARSQPAQKEGALPTGSSLSRGENGSQMTAATLSPEGNVAGTTLGDESTENTRPVRHHKKHDRQRHDKEKYPNDRDIKDRAGTGKLPRSRDSRSVGNKKRAISTGMYSKLAIKIAEWNGHNLTVDGITWPGGSSIPPKGKPEKYVLKVVTWFEDPHVLFVPQNNITHEDDEICDTNALPCKVYENRDEKSHRLDNVTTDMCCTGLCIDLLKRVSEKLHFEVDLTEVPDGRYGSPLNANQTEWNGMLGMLIHHQADMAMGALSITPERSKAVDFSVPFLQTGIAIIVAIREGAISPTAFLEPYDYPAWMLILVFSVHATGASIFIFEWLSPYGLDQGKTPLSVHKFSLFRSFWLIWAMLFGASVSTDMPRGCASRFLANIWALFAVVFCASYTANLAAFMITKDDFYDLSGIQDWRLKNPHHRQPPFRFATIANSSTDLNIYKNYKEIHNYMKTFAQVDVKDAIRALKHQDIQAFIYDSTTLEYEVGKDVGCKLKTVGKRIAETGYGIAFPRKSQWVKSVNKVLLKMQEDGEIERLQRFWLAGACHEKKETGVSSHTLGILNFTSAFILLGGGVILGLVLMVMEHVYFRFGRKSLRKWDRRGCCSLVSLSMGQSLTFEQSVMEAIDFHRQHKCKDPLCETQLWKVKHELDLALLKISQLRKQIAHTASLDPSCTQSREGSFKREPDAPPTQNGTAARRRRRQQPSDSNAVTSDPTSSRPLLGADDCDEDDLLDKPLMYPDERTHPPRTDQPLNAARSSYPSSYPQDVLEPSSRYSYPQQSRPGDNDKRGSSGVGVVRPVSRGPAPRDEGSERFADLDIHAPPPTFDEALAQSPTSSGGEGRAVSSPSPPLPPPPTSPSTFPPPPVAHGTGFPAPPAEELYTPAVAPRSRVPPPPPVRSFVPPPPPPAEDDEDRRYDPVILDSPASPASSSTFSDVSNNVPSSPGGISKLSKEDSGTSAATSPEPNSSIGSSRDSSERVGSSKPTTNLPSQQSSRVPSQAPVSSSQGREPPSNNVDKMKPSAEERELSYVSSPREADNDVSVRRPRDNDGNVYVNVDDMGGKETSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVH9</accession>
    <name>A0ABM1VVH9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transient receptor potential cation channel subfamily A member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101859749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826421.1">
        <property type="nucleotide sequence ID" value="XM_035970528.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859749"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="898"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="999"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1071"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="677"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1215"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035826421.1"/>
        </source>
    </evidence>
    <sequence length="1264" mass="141692" checksum="D0EAF2BB7612669D" modified="2025-10-08" version="1">MPSNSHEKRQLKKQDALMDMSHLNSNTCLSGDCSPNLNSRHRANDSSNERISIISNRTPPRKNSDGWDIGRKLNHKKSCYDHCSLPGEGAAMLDSHTPGKDSGGGGGGGGGGDSYRRPSRLLDKIRMFSKMRSLTRPSKTDSSQENHVLEIREDGPVCLIQESPNRIFRCAQNGSVKEVVRILKSDPTRLHARNNQGQMPLHVAAAKGKVNVVEALLEHEADVDAVDNQGNTALHLAVEAASPDICNLLIKHGADVDVVNSHHMMAIHLAADLGDVDVVKALLDNQVDPDSRGESGMTALHYAASKDHGEILRLMMQKGAKPCAKCDYGYYPIHLAAKCAAADAMEAIIEQALTKGYTREQILSFKDRENNLPLHAAVNGGDIKAVTVCLKAGASVKAQQDDGSTPLHFACAQGNMEMIKLMESMQRDNFIAAVFTTDAMKMTPLHRAALFNHTHVMQHLLEHGADIDSRDSVERTPLLLAASKGCWGTVQLLVSNGADVHVKDKNHRNFLHLAIKFGGKLEQIGGDFVKDIKNLQNERDDFGCTPVHYASREGHLLALDDLIRMGAVLNLKNNQKQSPFHFAARYGRYNTCRRLLDSVHGPNIINETDGSGLTALHIAAQNGHTKVIQLLLERGAVVNKDNEDNSALHHAAEQGWTHSMKVLLSVHSNLRDVANVDGDTPLHVAAKNGQTSAVSLLLTMGAKLLKNHEGIAFYDYVIQNKHREVAVAVVNHDRWEEVLTLHSNIYGCFVLGLIQHLPDVCLNVLNRCQTYSQDDPRSSQYHVTYNFKYLDTSTTCLQKSKEQKSGYLPMMALNTMVKNNRVDCLSHPVCVTFLKVKWNKYGMWIYTAYLLVYMLFLASLTSFVVNHNSLRHHDYGADNNTTIYLGGNTESGYNYSPIYMLALWFIAVYSALNVVKEVFQIFTQGTHYFADIGNGLEWCLYITSLVFSTPFLMGMAFHFQWEAGALAIFFAWFNCLVFLQRFDFFGIYVVMFLEILRTLVQVLCVFSILIIAFGLAFYMLMFKEVSKAYSTPGLALLRTFMMMLELDYMASFNEYFVDGDDRTLHFGNLTLVMLVIFVLLMPILLMNLLIGLAVGDIESVQRDARLKRLAMQVELHTGMEAKMPMFLHRKVTITEYKQYPNRCKKKLENFFSMISGANSDFGGKCGDMYSFQNSYMYEELYKQKVRMREMSGVLDKNNQLLRKIMQKMEIHTEDEAWDEGAGGSSDDSGDEMRGNRNRFKSKSFKEKMYLKSAVVSMWQKGHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW46</accession>
    <name>A0ABM1VW46_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Techylectin-5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826638.1">
        <property type="nucleotide sequence ID" value="XM_035970745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857728"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="170"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826638.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43444" checksum="8557470C31F23AFE" modified="2025-10-08" version="1">MYTYSNVTLQILSSIVEENKNDYLQRLRSQRETILEHVTTTAEEGKRQCAQQKENLLQNVTATVESLRESFESKWKSQLQVLSHTVDQNKKECPHQMLSQKRQILENVETIMEQNKLASVQLEERILGNVTATFEQNEMKFVQLETCILGNVTAMIEALEAGFERKLSATKTKLQTNTCADVTIQAPRPVVTLSNGMQVVCDTETDNGGWIVVQRRTSADVDFFRGWVDYKNGFGDLSGNFWFGLEKIHQLTKKERYELRVDFTYKGTNYYAIYKNFLLLGESENYKIKISGYSGNAGDQMIYDNGQAFTTKDRDNDPNNSGNCARIRHGAWWYKQCGHVNFNGAWATEKWAKGVCWYRVTGWGSSATFSEMKIRPLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWU8</accession>
    <name>A0ABM1VWU8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 20A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826890.1">
        <property type="nucleotide sequence ID" value="XM_035970997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851382"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052666">
        <property type="entry name" value="CYP450_20A1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24280">
        <property type="entry name" value="CYTOCHROME P450 20A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24280:SF4">
        <property type="entry name" value="CYTOCHROME P450 20A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826890.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23820" checksum="ADD35516CACD301B" modified="2025-10-08" version="1">MLDFVIFALTCFSVLLVAIKMLYRSSKMVTTIPGPDPSRKEDGNLSDIARAGSLHEFLLDLHSQFGDIAGFWWGQTYVVSIASPELFKAHANTFDKPAALLGLFEPLLGSQAIVYANVSEARRRRKVYDRPFSHENLKKYFPEFQEIAAMVEKKWSLKTETDYVPVGEDMEFFSFRSTLSTLMGDSFHDEKLVQSVIKAYKTFGHKSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VY11</accession>
    <name>A0ABM1VY11_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478236</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827304.1">
        <property type="nucleotide sequence ID" value="XM_035971411.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478236"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827304.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="45599" checksum="8056F9A4C3290113" modified="2025-10-08" version="1">MPGIKNSVTPDLNMAITHSPKSTTGIPASDTGVHTIEMSATHGLAGHNHAPPTSEQTTNRSPITAVTDAQGVTIDVPIRRCALRPIHEPVRAPISNIESNGSPCTPYGSSRKLPKISTDPSSNHNPSPSPLTLDLTDRQGFVDSQTNHNAIESPPYNSKAFPLIDSANSHSDFGAKYDSSNNNGSAISILSTFKLGPGVHVTPPPPLLRLSPTERSPDQTSKRQKLRFKDKEDVGNIFTRSLDTGSRSNDNGEFKTVSFVSPKASLASTDLHINSMSSINSSRQHSALKLNSSSQLFPETGKVMLASELSEEDRRANAQSAHSPLSPNDYSSDSNVTILAGVCRCANLSTARGRRNHALMIMLVSVIPVIALLIQNSIDVYDHNEELNLHRGVKNQILFRKLLGMIKAAQDGYKSRTIIIVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYG0</accession>
    <name>A0ABM1VYG0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106012685</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106012685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827453.1">
        <property type="nucleotide sequence ID" value="XM_035971560.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012685"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF2">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="80"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="153"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827453.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39215" checksum="CA5E7A6F43EC84CD" modified="2025-10-08" version="1">MRRLHRLNLKDELYEENGLPFYQNKIIVPLNLRGEILKNTGHVGTRRANDLARQSIYWPNLAQDIIEKYFRCYWRSAAKREKLADFVIIATVDREHKESTIAFAQLGYHILLEKPMAVTEADCREVVRVCNRWNVKLSVCHVLRYTHWVRKIKEVIDSGELGDIVSIRHTEPIGYWRFSHAFVRGNWSNEAASTFSLMSKSCHDIDLINHWMSPHRCRRVSSFGKLSHFTKENKPPGAASRCLDCPYKNSCLYSSKRFYLDLGHTGYPLGTLTCEVDIENVTDALRTGPYGRCVYDADNDVMSHQVSALTTEYLALLGVDALASLLLLVYAAEAFYIYIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYV3</accession>
    <name>A0ABM1VYV3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101848308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827596.1">
        <property type="nucleotide sequence ID" value="XM_035971703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848308"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035827596.1"/>
        </source>
    </evidence>
    <sequence length="683" mass="76639" checksum="F4FE28A64AE3D6FA" modified="2025-10-08" version="1">MMFHNAVSTKTCQDPPGEMAVFIASDANTRKALDAEEDDDEEEVRDQWTRGLDFVLSLIGYAVGVSNLWRFPYLTLRNGGGAFLIPFFFFMTLAGIPLFYLEVCLGQFSGISSMFVWRMCPLFKGVGYGMVIVSGMACIYYNAVLSWVIYYLVNSFYSELPWAHCGNWWNTPTCVDSSGANSSLSSGDNNTFFNDNTSLPLLNGILDFHSLNSSSFSNDSLYHLWNSNFSVPFNESGLNASFLCNWNSSFCENTEDKVKTAAEEFWQYNVLRKTEGLEDLGGLQMHNAICLLVAWVLVCLCLIKGVKSLGKVVYVTALLPYALLTIFLIRGCMLPGAVDGIIFYVKPDFEKLKSFTVWIEACVQVFYSLGPAWGGLITMASFNKFHNNCLRDVMIASLADGLTSFYGGFVIFAVVGFMAKEANVTVTEVATQGPGLALVAYPEAISKLPIPQLWAVMFFFMLLLLGLDSQFGMFETVICGLIDAFPKQLRKKRIMLTFGLALISYCVSLPIATRGGIYVFTLLDWFVAAFCVMLTSLIECIIIGWLYGVDKFCDDIELMIGRRPGIYMKVCWTVVTPLVMLVAFIFTCAKYTLPVYDGYVFPTHANAIGFLISVIPLIPIPAGMAYVLFKEKGTFSERLYSSVQPSPEWGPGARRYKAMYEDHKEERKHRPYWLKTLFRRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W009</accession>
    <name>A0ABM1W009_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose dehydrogenase [FAD, quinone]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828002.1">
        <property type="nucleotide sequence ID" value="XM_035972109.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853728"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828002.1"/>
        </source>
    </evidence>
    <sequence length="665" mass="73688" checksum="562782B9CEEC9379" modified="2025-10-08" version="1">MGPWTILFSVSGIVFGTGWLIQWKLNELPELITKPDAEYDYIIVGGGSAGCVLANRLSEVSSVRVLLLEAGPDDRNNEEVTIPIKAADSVHSNIDWDYYTVKQKDALQAFNEQRGWWHRGRILGGTSNVNEMLYARGLPKDYDNWGVKGWSYKDILPYFLKSEDNENADFVKTGYHKMGGLLKVGRSKTHALTNFLVRAGKEMGYNIIDINAVSSEGLVEVQSTLRKGVRQSATKAFLNPSMFRENVHVMTDSLVTKVLIENGRATGVEFERNGTKSSVKARQEVLLSAGTVGSAQLLLLSGVGPKKQLDSLKIPVVKDLPVGENLQDRLMFEYPVAIEPAISITQAQLESFWEQIKYKLIGKGMWASTNGVEVATFSSTRGNQQQDWPDLQHLFRGILPDLNQAAALGYSNKTLTEMANRSKFVYGFSCLGNVLRPQSRGNIRLASVNPRDMPLIDPKYLEKAADVEILLEGSWRFLLTLTEMANRSKFVYGFSCLGNVLRPQSRGNIRLASVNPRDMPLIDPKYLEKAADVEILLEGVKLCKKFLEMPSMKQIAAVHAEGPSSSCGKFKFDSDDYWRCLIRARALSAHYPVGTCKMGTEQDTSAVVDPDLRVRGVKGLRVVDSSIIPMITSGGTDIPAIMVAERASDVIKANLQKRPQGQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1B1</accession>
    <name>A0ABM1W1B1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polycystic kidney disease protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101850676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828454.1">
        <property type="nucleotide sequence ID" value="XM_035972561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850676"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1245"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1531"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1563"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1609"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1660"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1693"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1721"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="11">
        <location>
            <begin position="831"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035828454.1"/>
        </source>
    </evidence>
    <sequence length="1859" mass="211587" checksum="72906E350E2058EB" modified="2025-10-08" version="1">MQFTTDAPEIEISCVVNCGARTAVSSDYKLEVSCVFCSHYEFIKAKVVWELKLHLNVSTTPETFQDVPNFQSFTETLVDNHAALVIKANTLTAGARYRLSARMKIETRDAEGWAFQIIHMNSPPFHGTCYTTPHEGILTSLFQTTCSGWLDDGFEDKYRTDNRPFALTYKHYIKNGEEIIPFFQGGEATSPRSKLPILSDDNSGQYQIITRIYDVQEDYAEVMHTIQITVTSRSLEEAAEQVATDKPTDYAFEKSSLKKQLLETVFSAVVLQAVLGRNLTSFGQSMICSTSNLTSESYDPAVLLPEESIFEKIKVMEENQKKQDTKKQELSQEMRKLINQVQGRRHDYEDLDGYGIEALGETLYSVMYSDHNIDLETADIGSDVAEEGALKLLNLSSASIFPIGDKLDEVVAGLIGALDKTLARTTPDFHHTYLHVEICTEGLNAEEKLYFQKRIMDERMALNKQRTQAAQTTVPKVEDIITYLWKVMLSSEVMGQHMKKAFKKDLALATAKISARAVKGLHFAGRDCSIIFKAEFNQSENDNRNLNVKMSEVRKNPYTYAEDDSAHDISPPVVSWQLEDEEGHLHSAGKELSFNCTRPISNGSIGVFSVNKTRQGEEGLCHHKFQLKKDSEVIFVFVDIGNKTTNLTGYFRYDEAPTTYGSNVVKLASEPVVGDLSMNGSGKSFVNRFFVKPLTFKRGLIYVGLAIPEGVDEYKFLVYTDSCRVWNRNQSVWTNESCKVSPLSSLGNTVCDCFDAPDYTFGSSFYIPPNLIDFDLVFKKFDAENASVYGTLISLFIVFVFLAVWARRKVKEDIDRWQVGYLSDNLGMDNYYYLLTVHTGLSRGSGTSSRVSFVLTGVNGDTGVRLLTDGERHLSTGSVVTYVMATPYDLGELSYLRIWHDNSGEGQNQSWYLNKIYVEDLQTRTRSVFFGNQWLAMDQDDGRLDRIIPVSCKNDLMTFSRLFSEHSRVNLTDSHTWLSVILCPEKSMFTRVQRLATCLMTLHLAMIANALFYKPEDGEGVSSNSPGPEIQIGQLRFSLTTLYTSVVSGLITVPPVLLVVWLFKQRRPWRSSEADRSRRLSSHHGGSTVPLEGNLSDSKASLNIPDSCEANLVSRFDKNPLPPWCLYVAWTIMTITSLSCCFFLLLYSMQWGKTVSEEWLASFFLSFLESVFVLDPVKVILLTCFLAFFLRNPHEDYDSRVSLETVCLEAPGRGCQDRGSIPVPPAPVPDREVVKMRNQKLQEQVAVGVLVELVLHIIFMFCLFSFSYSNRDERSFQFQDHVLENLFRIPKRRVNSRASDYLLPWSKVLTHQDVFTWLNTTMTTRMFPASFLSRKELSLEERQFTADMANYRVGPVRVRQVRTRQMMMSDIHVDKMTSHPEYLVGEKQFYWPYDITSEETGSYCMGWQHKPCSLDKEYIESATLNSWVHRSILDENSIPIMGKLHLYSGGGYITDLGGYHDIIPDVFISELYENRWLDLQTRAVFIEFSLYNVDANLLATVRLVVEFPVYGSGFPWVDVRTLRIYPHVGPLGSYILMCSIILVISLIVFSFKVMKQLFREGRLFLKSFWGTMDLMIVLCCIAAIVFYILKTKLSSDVMGRFKEKPKLFVNFYALAIYDDIFGWTLAFIVFLSTMRIMRILGYNQRVTMIATVLQRAGKDLFSFSFLYLLMIGVFVMFGYMLFHSTEDDFMSPWNTFVTIVYLLLGKNVIKNLEQAPPVLVRIYFALLSFTLVFVLMTMFQAILNASATQVRTDAQNAPEPYGIINVLQKMYNSLVVNNRLLAFLRCPIGKRQNQRVSPEKNHWMFGEPETSDALVVFTMMREYVHRLNGDTETTMEGLKKEPAMAMGLTRRTAIEVSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1E8</accession>
    <name>A0ABM1W1E8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101857518</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101857518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828491.1">
        <property type="nucleotide sequence ID" value="XM_035972598.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857518"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045471644" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="40"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="657"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828491.1"/>
        </source>
    </evidence>
    <sequence length="1187" mass="131644" checksum="F2633B680284BE7E" modified="2025-10-08" version="1">MLPTTLTGATLAFLGMLSFALRNVRATEFVSVQLGPTQWLRGKVTTLSTGQPMNIFRGVRYAQPPTGSYRFAEPRPSSGWNGSQDALEDKPRCLQTWLPDPLKPESEDCLFLNVFSPNVTGTVPVMLFIHGGAYYRGSEDIFDASLLASQGVVVVLIEYRLGLFGFLSNSDHVIPGNYGMLDQVLAMKWVQKYIHVFGGDPEMVTIFGQSAGSAGVSLHVLSPLSKGLFKRAIMESGVSLSPFAIYRAKTKLQSSNYTSLLGQELGCRTDSSKVLLGCLREANAIHMMEASSRIRWHTHSDILATPTVETTYGFLPDLPYNLLKSGQFNKVDTLRGYNSGEWSFVIFDPVDEGISRDAFPKNFARMFKTYGSTQDFETIVLKSIENAYLGQHTDKKVIRSQLVDALAHFAFALPGVLESRSMTKYAPNHKHYFYEYDYRVSELVSIISVLPKWMKIVHTGELKTLFLEDGHIFASETDKAVAKQMQTMWANFAIFGNPTEKNVPQHLQWVPYTEQNNAMMKISENSKMTTFSRPENVPMYEKLLKIAAGITPDLFVEQPLFEILNICFVIILQFLPCPYLAKGFCNYKAPDEFIFTQQNNYKSLVELGRCCICRKISIVSPSTKMGISSCLTFLLVVLCGVAHCRLRRQTSTPDYVTVELSAGQSLRGEKITKDGQGLNVFKGIRYGAAPVGSLRLAAPQEAPSWTGSQDALDLPPICWQRKQTDPHHAQSEDCLFLNVYSPDINGSLSVMVWIHGGSYNRGAGIRQDPSQLARHGVVVVTLNYRLGPFGFMSSGDDTIPGNFGLLDQNLAMKWVQKHITAFGGDPASVTIFGQSAGAASVSLHLVSPLSKGLFKRAIMESGSSLASFAVERPATKFQQSNYTSEMGVRLGCNDTDSPSLLTCFRNVPVSQILDEDHNMREETGTDILVTPTVETAFGFLPDYPSNLQKAGKINAVDTLSGYTNGELSYLISDPDEDGVTRSEFLPTFRKTNQTYAFNKESVPVVDRFIESYYLENATNPIAIRSRLVNSLSEGTFGLPAALEIQRMQNAEGSDTKRHYFYEYEYRISVLLSFISLAPAWMGIAHAQDLEIVFFNDKIMATNSDRAVANTVQTMWANFAMYGNPTEKNVKQDGVDLNWTPYTKANNAMLKIAAKSEMTTFPGSDRVSIYAKLLENFIGNSDAASLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3K9</accession>
    <name>A0ABM1W3K9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850860</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829252.1">
        <property type="nucleotide sequence ID" value="XM_035973359.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850860"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829252.1"/>
        </source>
    </evidence>
    <sequence length="721" mass="77964" checksum="8CCE20562FC5485A" modified="2025-10-08" version="1">MESDEDQMAGSISKSSSFSPKVTRPKLPPFAGSGSRSVSPRAKTDPGRGEIKAIMEDIMNLKKTDWKTFSRSRTSPHSKGKSMSTNTSPNSSPRIGSPVADESRSGLTRDRSRSLKLLTDRLKNKNTGAKPPVPEKKPEDEAKDVVIVSRTIELQPSGNKCEQWTPHNASVPSLPPGGSPRRSPDRRSMERTYEQIPEFPEDAEQEAEAEGAKSPLTASSEESFRSAPEVPDDGAREKSPDSDYAGGIREKSPDSEGGCSGKSQDDYDRHHGDKYKPVDDEGIGEGGEASAPVVSTYIYHPIPRNSKFLQLAATKPPKRFPPERRSGITMLATRGRVGGISKSTGDDHRPSDDQPSRQQRLQRRSDSAKSTAPKSSPRFITHPPHMKASHKEAGSVDTNGFAALKSTGDSEDELKQHSQVSLADSQFASELSDEPTYQDVVDCVTLDSNNDVSDRKNGKSTKQKSKSDPSGDRAREMLEFPQSLESPQSHSAPLLSEEELEAMGFHKGMTISEEDARQKSRSETLLSSPSNLDDEGREEHSSGGEDDDGSVECYKGSDTAAQDSSEFVALSPTAGSSKSSSKSIVISAPGTPHGPSPAPSSERPTNLLSVPTSTSGGGSGRKPNIFRSASSASVLQSRKPVGSPLREKDVVRKYSITSDEAMINSKSSVNLVPDFLPIGDTSNAASMPAVWNKDRLHSSDSPEREPGFIKDKRYHIVEELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3Y2</accession>
    <name>A0ABM1W3Y2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829375.1">
        <property type="nucleotide sequence ID" value="XM_035973482.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863793"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829375.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38834" checksum="4C43E38997A08F64" modified="2025-10-08" version="1">MARFKGRCHFRQYMPDKPTKRGFKCFSLCDSVSFYCLKFIVYTGKDYFPVPAGKPFTHHLVETLMDGYTGKSHILFCDNFYTSPALFADLREKQTGAVGTVVESRKGFPHALKHTNLPLKKGDEPVFSRSGDMVATAWHDTKRVHLLSTVHTNNTMDKLVRSAKDDGGFRRVEKPVIAETYNAYMGGVDHFDQLHKNYSYPHRSYKWYLALYLYVKDACLVNAHILYKRSGGKDNVKDFKSAVVDALIKPHMAVRKSKCRPQPNPTVDRLSAAQFGHFPAKYLDPKHRPVCKVCATIKKRAQTRFHCPQCNTALCVDRDCFRIWHTAVDVKQARQQLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W412</accession>
    <name>A0ABM1W412_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein unc-79 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829405.1">
        <property type="nucleotide sequence ID" value="XM_035973512.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860711"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14776">
        <property type="entry name" value="UNC-79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1566"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1645"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1681"/>
            <end position="1696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829405.1"/>
        </source>
    </evidence>
    <sequence length="2369" mass="266819" checksum="D6AB4273141EDE6C" modified="2025-10-08" version="1">MATRAATFTSKIRNLKEYHYKIVTNIAPLPTGVDIANTLKYFSQTLLSVLKDVPNIPIENYGLRQKDSVRLSIFPTLNYSGLYQAVLSILDLVPVVQIGQLALGEAVLNVLGWLVPFLEHDLLDALPYTVASTLAIFPPTLHKDTIDLLCTSLLPMTLSADVSEEPTYASESAAAIITMVFQHTENGAFHSQILECFMSMKKNIIKDILSIIAYAPPTAKAPAAHLLFYYWPQLNPTLSDRRGIHYKYSGIEFTAWPAILCQRKGCINEGNCQAVKMCINPALAIHSGDTPPPLYICSDCTEALKKDHGEYMMDLLMPMPHVSSVCENKNCKSSQNIAICTCFSIECASYNSNRPVRYCSTCHERRHGNSGSPNHIFHTSISDIWGCTPEVQRYLMDAIVSLLKEASPIGTKRMVEMGEDLRRMPDDDDGFEVEDVGERKLLSRYGIWLLVELCKPGEDIPIEVLGRLLGMLFQWFDATAYLPDDNIGNALERLKPEYIYSWLQEVMKTHFEVIVSCLLPHPVEYSRVGGFWDTLCTRTTQIKEGLNCFFCLVPYDVISFEIWDYVMPYWLEAIRTEVPEDELHELKVLLSKAFDIDMCPLPFTLHKMYNFVSDRFNDTSASVMEQALQWLQILGSLDIVIPMHQILKMFKMGVEKISTDVENSQPLQQEEGQGHSILTPGSPAREHAAPLSPERFPFVSDPYDLYDKESELVLPCFVMMLDLTLKQMDLQEAPQHLGIYNETSREVMSLLTGMLHKNWDGQHTCDTDTKRVNCMFCQNIALWHQLAAQLMEHVCPRDPLKIPNKDLPKLDDMKPHTRTESLNESVELDEEKEEPEFNIPAMPMYLQLYDVLLESLVNVSDVDALYAVLSSLRYLILHGECLNYTINQYTEFITISFRKRFIPTLWKLLQTEHSQLATLCIPLLLHCITLPSGSHTLWCLVEQDFGHDDWRARFAAVEKVTMIARCLEPEVIRNNHIIQTSLAHTFCHLIGAVEDINASVAQRAMMFLETIRPAALKCLCSCLEFQFDSVIEDRSLILHRIQVLENALRDVLILTWEFFLNRFDTLSLEAQVDLENSGDIPYPTDLTSSDRHSEHFQRKLNRAKFALARTDSVRSVSQSMKGKPPYRRAVSVPLHLITKGVSPPKLNLAQHHQEPSETERKQRSLPHIFDKHSKTFLYKRLLMEKEKPCVRQWSAPQFNLPRRMPSKLNLGSFGASMFPGGQLREFTDEESNFAALLQRAMEGVDRDTVYQLVSLLMTFMVQCNDHDDAEERTDTKAQNIVLRHLNVLLGYNQTEKSFSVPPFKLRSSAVFNAFLSGVMYVLDRNFKLGYVILSITLLVLQYCPSPQRYASDNQPATYTLWYLEPHTRVSWLKSLLVILYKYQISTSPRSAIIQSLVQLVINTIDAQHHRCKKTEDGFPPPTPTVHRSKADLSKISVSDLENIQETDTPPQSPSSQKQENGEMASVQVKPHATGGMVHYFKHVHTDGAESSEGITSDAEGTPPTLGGIRKDGSRKQMKARQPRRLIEYSEPDSADDDSKDLTERSDAPLLSQKTKSPISVEKKMAQQLQEFSVSSSQPTVAGGHSNPVVHGGATSSSATTEGSSGREHGTTSDHSREAASEGETSDDSEKTQTSEGDSACDATLEDSKGSDSVTEKRVSPVLKPNFRQRRPRKTGLTTIDFQRKFPELQEEKHPQEEPSQAPRSSSRRSRKAELLAKQQSMKKVASVRYGENVMVERCSECNAVLEQYDDDTIGLCITALATFIHREPGLATPMLLDMLQCVARIASGSHYSWQAESNVIIPGNCVSIARQFLRCVLHQLAPNGIFPMVFQSNMEDPHFWKTMAASLIDFSDLPSHAPLQYLLEGLNERKNLPQDSIMLLLNNMATYLNCVSLESSLPMWTAILTHFDTFLRRLPLVLPNPCDMGPILKIIITLLKVYYIGNVRGILEPFSKILSFAIQNCSFKLQQLLDICSLCNRALTRERDKMFLTRTVIYELVQAIKFKSSIPDENLLMLMQFVVLDAGGTLSLYNTSGSEAGSLYSTQSPSLISTCAAECMRQHLNDCLEFIADLHTISKVKANMKVAGASLNEDTLGSQLKSGVSQYLALEITRGNGRDNRAITRYLPWLYHPPSAMQQGPKEFIDCIGHIRLMSWLLIGSLTHTAVTEGGAPISCLPLPLEASCHIADHIMVIMTGFAEQSSASVLHMSSLFHAFILCQLWTMYSESAAALHSPGSEQHLMASAMIMDFWARVTPGILQLLSHSKVDKPILELAEMVNLHFLSLMEALQECNSSVLAKLFPMWTSILFAYHAQLPGHLQVRLQTCQNWEPPHPTKDQTSFNSAILLSWLKRIQFKLGQIEVQSSAATQIYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4F3</accession>
    <name>A0ABM1W4F3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microtubule-associated protein 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118479057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829546.1">
        <property type="nucleotide sequence ID" value="XM_035973653.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118479057"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026106">
        <property type="entry name" value="MAP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14739">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14739:SF9">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829546.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="21888" checksum="D2CCC3346C4C49DE" modified="2025-10-08" version="1">MEKKKEVLKVEEEKKKRAEKDKEMKEKEEREEKMVESVKSFQSWKEKKDHMIKRELRKKEQAEQRAKEDEEYEKKMKNKERESAFRGWQRRKEKEWKSNANNRKEENKTKKEKDYEEKEVAREKEEEAMNRYYEWMEQKEKQAKLEKKRAKQRRLMGEDEYKPAWSPASKTIPFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4N5</accession>
    <name>A0ABM1W4N5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hornerin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829628.1">
        <property type="nucleotide sequence ID" value="XM_035973735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863648"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="892"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1426"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="482"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1343"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1373"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1463"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829628.1"/>
        </source>
    </evidence>
    <sequence length="1473" mass="154899" checksum="102489CA4D6C625C" modified="2025-10-08" version="1">MLDKFKFFKDKDKDKDKNKSGGGGGNSGGGGSGGGGGGGVVKSTSKNSSTSTSTTSTSSRSDTDSRTSSGDTAKSSSFTSSHSSSSGGGDGGGATSTSSGLPSAPATPSKSGGGGGSSKSGKKSLVKAFSSKKDAAHHDESPRAQIPPPIPSAQGLGPPTGGPPYAPAASQSASRTASPSQSRKSGAKNDRSDSRQAAADPRMATASPTPPSSKKASKLASLSGIPKTQSSSSGKSSSSKAPSSSSSSSQVAVSSSSSSAGPASSTGIPKPSSSKSSGKLSREDKARAAAASKEYNKALYKDLPGMGVPKAFGSSSKQSSSSSSSAQQQHQQQQLQQYQQQQAAYSQRQQQQQQQQQQQHSSPHHSQQAASYSHHHHQQQQQHHQQQQQQQQQHQQQQQQQQQQYQGYPPGYPSQHYYNPHSVAEHPYNTPHVYTPPYAHNPGYATPTRVPSSPLIQNVHPRVNIQSMERQQQQQQQQQQYYHHYQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVSEQTSAFAPPQQRSTAQASHYVPVTIPAINMDTHPTNLAAAAAQSGRCSKQMLPQSPMMSPNLGRHPNGQQPSVNVVKPTMASASPSSTSAQKSNKSDSNTQTNLSVLHRSATPKHITASSESGKSSPRLGGDQSPNLNASRSSNSSASPASPAMSKKSSKSGSNTPDRTLDSPGTGSSSREGAMKKCATPEKELESPRSKSSSKENLLGDGSESDSLGRVSNKELPGSGVEKSLTPSNTSSPKLGVKMLGSHIAKNASNVAVVQPRPGEKMETTFDAEVRTETIHKMSSEQEKAQTGGKETTFLTPEKEEKTTFLDDQGETMDIKPMPPIMRALPYGYFRGYSGYGGFNNRNFHIPGISVPTTAMYATRTGSAQGLGMPPRPLGESSQHGGPPKFYSAHIKRAGSASSGPHGPPPPHSSSSDADYASESDTYDYVSGYMSDGDILKNNRNNGGGGAGADDWSSGYLSEGGASLYARRLQQRFREGMQAVRECMQKSSGIMDDDSFDDSSSISSGEISDTIAEISTDENLTGSSQGALSDNPYNSLKRTPKDILSIHAGYGTNGGSSGHPPPLGHPPPPPGYAGKRVPTLGTSAFMGTDYNSDSGIGSGWGRKYSLTQAGKFLSNDPNKLLSSDPSDYGYGYGWPSSRSEGGYSSLRKMSNGSNPDYAYYSEGDYDSPHRSFSPAPGVGGMKKDTETNTDQSHLLEASMRRLNTSGTRSGNATPPGSNGAGTQFGYRRSLSNASNSSAGSSSKNGGGSSKSSSHGSSAVGSRLAKHGVDTGQRSVHDIPRPASAAGKPINPDMALVEGYNSSTLDRKKKNGGLTPSKSTGCTQTDRDFQSSSLGRRRLFGSKGNLNKSQGDSPSPVGGTIISNPHATYSRGGEKPSSHYVNLQELHARIPGSNYVPLEFASSPRNSSLGSPAALGPGSMWLKSSHSSNGVGLPPGPPPSHSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4Q4</accession>
    <name>A0ABM1W4Q4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101850306</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101850306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829647.1">
        <property type="nucleotide sequence ID" value="XM_035973754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850306"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035829647.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37327" checksum="64A24F24352AFB58" modified="2025-10-08" version="1">SGDGEVDKMLSKSLGSCFTDTVHYTQYRLQTHLTQAGDLDEIKFYTDVLLSLGLHCRDVLPSLRELVTFVNNVLHSAASGADSPQDLAKLDVLSCSAVRLLSTVFKIISRSKVLQSERSAVISEIVAQVSMPLSDLPLPFSRKGVSNDSGSRAQVGRVISRFISSKWQCQGHVLQHNKSGLDGDSVSSVLEQAMEDMTIGSGSSDIAIFQALLVIAPQIAQHAPPAKIPQFLDLAWQKLMEEKKNILFWKKLESLIPLGLHKSLMQHEDPEVEEGMKEFMQKLWTLGSEKTGITFLMFDHICGHILKDDPDRRLATKWTSLLLDACAFGNVHKKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4S8</accession>
    <name>A0ABM1W4S8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hyaluronidase</fullName>
            <ecNumber evidence="3">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101845825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035829671.1">
        <property type="nucleotide sequence ID" value="XM_035973778.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845825"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF35">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046607325" description="Hyaluronidase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829671.1"/>
        </source>
    </evidence>
    <sequence length="571" mass="65703" checksum="1BEE0F03A072B1B9" modified="2025-10-08" version="1">MLQLQVQTVGMLCLAFCFFSFFFFLGASAEGCTAPLILPDKPFFVVWNHPSFGCENHGVHLGFENWGIVDNSKDRFTGEQISIFYRLGLWPYYSGTNAVNGGIPQLTNETAHFTKVENDIKTVIPDATFSGLGVIDFEHWRPLYRLNWSKLRIYQQKSLELAKQRFPLFNSSQLLAEATKEFEEAARSIVGKTLSEVTNLRPSGRWGYYGYPRCWDEMCNTSTLKVNDEMRWIFNTSTGLYPSIYFDLSVPPETRHTRIKQKIHETLRVKAKFSPQDATVFPYALNQNGPFKFFTQADLSYSIEEPANMGSSGVVLWGSSSSMRAKNECLLLQDYVNKTLGPFVLNVTNFFGNCTQQLCQGHGRCIRKDYEKFFQHHLRASGRSTCLMNEEDLDSSSQSYGKRTALKLKNSNNSKKKADMEILNNLLQRFVDNSLKFRRRGELAFREWWYPVRLKELQDYHVQMYEQNKDLFKNQDLLQNEAIPIVDKFSISGLRNKNYAHFQTSHLSAPMSISSSSSRINFWQGEEISSDSSYGQDEGSDEDVQYDFDDYVCKCFEGWSGNHCDHKDKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W5C8</accession>
    <name>A0ABM1W5C8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="11">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC101847776</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005089107.1">
        <property type="nucleotide sequence ID" value="XM_005089050.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829871.1">
        <property type="nucleotide sequence ID" value="XM_035973978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847776"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="14">
        <location>
            <begin position="183"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005089107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035829871.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="41063" checksum="27215B914E09FBB8" modified="2025-10-08" version="1">MSDFNASDHTHRRYNPLVDEWIVVSPQRAKRPWLGQVEKAAADATPRHDPKNPLCPRVTRPNGQVNPDYKNTFVFDNDFPALLPDGPEPPENDDPLFQSGSAHGKCRVICFHPWSDLTLPLMNVTDIRCVIDTWVKESVDLGKKFRWVQIFENRGAVMGCSNPHPHCQIWACSFFPDEPSKKDKNQRTFKEKYGKTMLVDYLEKELVKKERIILESKHWVWLVPYWATWPFETMLLPRRHILRFEDQTDEEKNDLSQILKELLTVYDNLFEVSFPYCMGWQGAPTGSSLTEDCSHWQLHGVFYPPLLRSATVKKFMVGFEMLASAQRDMTAEQAAERLRNLPRVHYKNKEGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F2Q754</accession>
    <name>F2Q754_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="22">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">trk</name>
    </gene>
    <organism evidence="27">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>Invertebrate Neurotrophin Signaling/Differentially Spliced and Processed Neurotrophin Isoforms and a Cognate Trk Receptor Mediate Synaptic Growth and Plasticity in Aplysia.</title>
            <authorList>
                <person name="Kassabov S.R."/>
                <person name="Choi Y.-B."/>
                <person name="Karl K.A."/>
                <person name="Vishwasrao H.D."/>
                <person name="Fiumara F."/>
                <person name="Bailey C.H."/>
                <person name="Kandel E.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="27">CNS</tissue>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="22"/>
    <dbReference type="EMBL" id="FJ861323">
        <property type="protein sequence ID" value="ACZ37086.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001232923.1">
        <property type="nucleotide sequence ID" value="NM_001245994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F2Q754"/>
    <dbReference type="GeneID" id="100579130"/>
    <dbReference type="CTD" id="34376"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043121">
        <property type="term" value="F:neurotrophin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005030">
        <property type="term" value="F:neurotrophin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990090">
        <property type="term" value="P:cellular response to nerve growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000034">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000033">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF614">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 27 29" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 22" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 25 29" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 22 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="25 29">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003288587" description="Tyrosine-protein kinase receptor" evidence="25 29">
        <location>
            <begin position="28"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="614"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="476"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ACZ37086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="NP_001232923.1"/>
        </source>
    </evidence>
    <sequence length="902" mass="101523" checksum="70CEC2EEEBB1A128" modified="2011-05-31" version="1">MEANRIVYFLHTLGLLLWWLPFPCCRCGSNGSIACPEMCTCESNLTPNNTAGVIVTCNLTDTLTTLPQMDPKDAETVTELAIQNQPHFRSLDGEAIQFYKHLEVLIITNTSLKYVNESTFSHTLRLNTLDLRSNLISRFHEQIVKDTVIEHLLLSGNPLPCNCSHQWLQVTILHIDTDMFCLAQTQDVWRGDLAGERQSWNESGILTNKTADRALLALSDVDFSHCEKPLVLLPDGFLQVSDSQELSTRCQAHSDAQVSIAWSVPPLAAWWTTTQVYQGATAHGDNDDVDGAEEMTDVEKGEEGEDLGKVNETAKTSTYIAISEIQIHNLSVTDHYQPVSCVATNDVGSTTLSFRIIVPSAPNITSLRARKRYSLQIRFRVTGWPVPSLMWYHDGRVSPSSRLNQDYYSKNDSEKGEIHGARVFESEFPGMAGQYTLEAKNSIGGVNKTIWIAPGGLVPADINEFGLRPHPGISGVLRGRNKPANERVYGHGHDQLPSQSNETHPGLNSSSTNITATDKSFINSSQIIVITSTCVALLFVCAVVIFCIIRRRKSRVLARGRNARSQMFSAWKSTLQESVPLTGVQLVDNPNYNGHGRKRDESSSSLRKIKLETILLIRAIGEGAFGRVFLGTCAHLLKKDEFTFVAVKTLKGDCNELVRADFEREAEMLATLQHRNIVTFYGVCTEGEQWMMVFEFMEHGDLNKYLRDRDPDSRIRVHENNRADQPLHTDELMKIIMQIGNGMEYLASQHFVHRDLATRNCLVGSSYIVKIGDFGMSRDVYSTDYYRVGDAAVLPVRWLPPESLVYRTFTVESDVWSFGVTVWEIYTYGKQPWYEYSNMQVIEHIRNCKLLSRPPNCPDVVFDLMLGCWKANPQERLTMSQICNILREELSKHPVYLPIIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0J9X5</accession>
    <name>A0ABM0J9X5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM domain-containing protein WLIM2b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005088830.1">
        <property type="nucleotide sequence ID" value="XM_005088773.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847001"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005088830.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8418" checksum="7AC900F954F61BAE" modified="2025-10-08" version="1">MAPRFGGGEKCGICDKTVYAQEKIEAGGVPFHKTCFKCSHCKMSLSLQNYAQAEKILYCKNHYQSEVVAKNAQIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JB40</accession>
    <name>A0ABM0JB40_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0600 protein C5orf51 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089588.1">
        <property type="nucleotide sequence ID" value="XM_005089531.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852134"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037657">
        <property type="entry name" value="RIMC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28494:SF1">
        <property type="entry name" value="RAB7A-INTERACTING MON1-CCZ1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28494">
        <property type="entry name" value="UPF0600 PROTEIN C5ORF51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17716">
        <property type="entry name" value="RIMC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089588.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41673" checksum="276EAA1FDD51A4BF" modified="2025-10-08" version="1">MATGNTDAKQVLATYCESLLGEIRKQKQNTGDDNEKDIVLSLYEYKCQSLWEEINSCDNSALAQESNVVKYLQNIARLVLDSTYLEECTLVNEEFSTPTTWTTIKEIAGILNNVEKLAELAVPGKKPVVSLGAEIVECLRWRRGALCYMYGYTLNEAQPDRGYPDHYKQCLENGVSEILTMLSTRANPNWLRSHVAHNTESDRSQEQEVVCNDRTAARLFLEGILSDTHMLALMYCGELCYWHAQAVEKKIFPKSSSPGQSPDTSALSVSDFLARINGEVAEDSPSKCVSSSEKSGKNSESDRTESSEGKSSCESENSTGQKSDVKGQRTRQGQVYIDIGLLCLKKYVEIAQGPLSIGGWTTDQAKKILQYFSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBA6</accession>
    <name>A0ABM0JBA6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101862986</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101862986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089726.1">
        <property type="nucleotide sequence ID" value="XM_005089669.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937479.1">
        <property type="nucleotide sequence ID" value="XM_013082025.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862986"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937479.1"/>
        </source>
    </evidence>
    <sequence length="555" mass="63607" checksum="607E615A729DD2BA" modified="2025-10-08" version="1">MDFVSLPPEIIEKIFLQLDTQALAACALVDECLAKLIYGRHFLDEYCRKTFCCSWLTAQDVHDVDIAVPFEFWFWVYETVKAQDAHHGTVIYQSKYLTKIGTLKHLFIMWLMCGHRSSFIDSHALMNVLYPLPHTVHDVFDSKCKQPEPFIIDTLMKIFFSLPEIMHVSCSNLKVFSMQKGTVTTAPIQYIVRTKLKERLPKNFRPVFSVEMLCASNSARTPALVILMDRDWWILWFGMVNFSTDRPDGLDHFCYGTYSHSVMLGDIKLDAKSAIKHFNDHVQSHRDVSRGSSSEPAMRVLPCPLITFENSDMADMTFSLAQESLRGLQKKFQIVLNRTCSHVIKALRKILCEQDYTRVSRLFSTRASQNDQIDEFVLHLLHVDMVSAMFNPSHQLDFVVYKYILERIAFMFRNEIHKSLVSNFSHAFLCNCLGPSFPLKCCCNPQLTIEKCLSVKIKDGLYSPQMWPPHVLSAACLIMPALAEVLKSDILLMKMGRLKWALSRNAVSQLNQKLRISGLTLTNRPPGKPRYPPVLKQVRLLIVDSLGLTRKDPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBV8</accession>
    <name>A0ABM0JBV8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005090107.1">
        <property type="nucleotide sequence ID" value="XM_005090050.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845514"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005090107.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31906" checksum="B7DA8150D0CF0527" modified="2025-10-08" version="1">MFYLIGIGLGDAKDITVKGLEVVKSSKRVYLEAYTSILTVGKEALESFYGREVILADRDMVEQASDELMEGADTEDISFLVVGDPLGATTHTDLILRAVEKNIPYFVIHNASIMNAIGCCGLQLYNYGETVSIVFWTEDWQPESFYDKILVNRERGMHTLCLLDIKMKEQTIENLMKGRPIYEPPRFLSASQAAQQLLDIVERRDKDQKTDADLTPSSICVAVARVGASDQKISTATLKEMAALDMGPPLHSMVIPGHMHPLEKQMLRLFAASDQVKNDLASEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCI7</accession>
    <name>A0ABM0JCI7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101849343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005090553.1">
        <property type="nucleotide sequence ID" value="XM_005090496.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849343"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044992533" description="Peptidyl-prolyl cis-trans isomerase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="30"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005090553.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="21623" checksum="9A6F590833C7C669" modified="2025-10-08" version="1">MTSVAVLFLAVAVSTTVLADQRPLVTDRVTWDITIGGEEIGRIVIGVFKDVAPITAKNFIELSSGVNGYGYAGSSFHRVIKDFMIQGGDYSNKDGSGINSIYGGYFDDENFDLQHYGAGWVSMANAGKDTNGCQFFITLKATPWLDGQHTVFGKVLEGMDVVYQIGDTDTTATDGPVEPVVIARSSAEKATDALYVELASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCU7</accession>
    <name>A0ABM0JCU7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable serine/threonine-protein kinase drkD isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101859754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090776.1">
        <property type="nucleotide sequence ID" value="XM_005090719.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859754"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11419">
        <property type="entry name" value="bHLHzip_TFAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005090776.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61246" checksum="48730F0166CACE00" modified="2025-10-08" version="1">MMSVDIRNSERRRFSELEAREKEIAAGLVNRVSPPVSPKAQQENEKRMRREIANSNERRRMQCINAGFSSLRALIPQLEGEKLSKAAILQHTTEYITSLEKDKTRMQLQVEHLKHVLAELGQERVVTDPYISSSPPPSKRKKRDTAESSDEGVGSLSDGSDEGGTELRQENVALQHQLEVERQRCASLEEHNRRLEDQLYSLLQRQSAQAIRELQPVKLEAAHSLTPHEPMYSREVVEVIASRDVRPPSPPPRPLSPTPERGMAMDISTPPMDTSRHEHSPPAAPSPIKPLPIQSPALDSNNSSVGGLVQPTVGGLVQPAARVNPPSVPEGRVPHHHNYCHRDHPRRRHRHQAQLEQQQAEEELRLQQQQKQQLQQQQQQSQQAVPAQSLENLVEAIRQIEGDGVLCQMEGERMVCDERKLYEEEQRLYTKRQSIPTTEESERETSSISDMDEFKSEGSGRDSPIQHHHHHMVHLKQQQQQPVIMSSQPPPPPPLSTTNSSSIHNSGSSSFSEKYPIASHLLHRPLHPSFYNRPGVIVHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCX6</accession>
    <name>A0ABM0JCX6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Uncharacterized protein LOC101848794</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8" type="primary">LOC101848794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090820.1">
        <property type="nucleotide sequence ID" value="XM_005090763.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943114.1">
        <property type="nucleotide sequence ID" value="XM_013087660.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943116.1">
        <property type="nucleotide sequence ID" value="XM_013087662.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943119.1">
        <property type="nucleotide sequence ID" value="XM_013087665.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848794"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="553"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005090820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012943114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012943116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943119.1"/>
        </source>
    </evidence>
    <sequence length="612" mass="66932" checksum="5C1407B3F5AB8681" modified="2025-10-08" version="1">MLEPAAGCCREAVAAAHVTVGRTRTAQNARSVTMGEQRAPVTAQVLGRMVAVILLVLSHCLTGCAGVLSPLSHTQNLGTHFGNREPLEMVSSPLSSPSSSSPSSSPLDGVSVVDGNLEKSETSEHLSGLTSGSKGWDLVSKTYNDRPKGSKEDVHFHTYLQNLYQIKSGELRGGRVDEGKRLKVDNGKGYLLRSHDDTNSRISIKGVQSGGAPNDLLKSGSIRGDKSSSGAVVKVRNKHSPASNADDVRDKDHFASQIGYQKRIGDHQSIGLSPRHIYGDNTKYSTKYLHGESTGNRDTPISSNHGTENRQAKEVGGRSEIASDGVDSIDIAQLLSGKGQVAEIIASPGVINGVITNSGHGEKNSQDGTKPSGHSIELGEDDFESLQALIQETVHKMVERLDFNVLSHEERHHGSDVSSPPSSSSFSSSSFADTQNGGRLQDPKHQSIKAKHLGDKNSLKHWEKNSTDEHFLGWQEQFEESYNRVLNALLDATVSQSVPENFEFWRNVSSILDSSIYLSRTKRRSPRRRSRHPAFKARFLQHMRRQLAINYGHVTPCEYKDRFYCMNGGTCVIIGTLDIKTCRCPIGFTNTRCQEIDQEYILSLLSNSLVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEH2</accession>
    <name>A0ABM0JEH2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tubulin-glutamate carboxypeptidase</fullName>
            <ecNumber evidence="11">3.4.17.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101847472</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:63792"/>
            <dbReference type="Rhea" id="RHEA-COMP:16435"/>
            <dbReference type="Rhea" id="RHEA-COMP:16436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:149555"/>
            <dbReference type="ChEBI" id="CHEBI:149556"/>
            <dbReference type="EC" id="3.4.17.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:63793"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.24" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005091885.1">
        <property type="nucleotide sequence ID" value="XM_005091828.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847472"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06906">
        <property type="entry name" value="M14_Nna1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033852">
        <property type="entry name" value="CBPC1/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF11">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25571">
        <property type="entry name" value="TPR_CCP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="904"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="400"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="580"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1230"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005091885.1"/>
        </source>
    </evidence>
    <sequence length="1273" mass="144405" checksum="A0727A83559E6522" modified="2025-10-08" version="1">MSAAPAEPSDKLVDRNRLHYWVQHIAKVLSRNSKKLTLEDMQQIRYASAKLFQLVQQIEKPSKDSFMKQYSSVDTLITVLQIVSCEQTINNIVNIFIDCVGKIQPAKRATVLVNHGLTTVLFQMLKLAHTTEITFLEDTLIAIHVLLSRIGHKDRKFAVKARLHQSLMLTLNLVKSNFHNFRSLQPLLQVLKLYTNNSVNASYLGKNNSINIMFKVISACGKRHTVDLRLALENLSNMTKSKSNSARLIGMGGVPQLLTLHSEWQQMDTKHRNLSIRRAILLILRNITNLKSGRKAFVDADGIRILYESALEASDCRDMESLILLASVILRKCYPRNKLPIDSTLCPARFILPDSPNHIPECYSLPNYPDSDNREGLLPSKFGRVYDVVRNLIGGAVPVCSWQDGPQAEESDHSSMDEDDDVDSDDEEFRTDTEEPDDDQLDGLEPAERRTTEDLRMYDTFFPELFLNESSQPNILTSPAQSSTSDFTTARSQTFMSPPDVLGMRQTVSDVSLFDMYRKANMDFTTTSRYYQQAPSSCGRPATHSQTFVKGLERDEKSVSAINLKTGSSVISLELGPRPSATAAKSAKSLPKGKPKKRSVTVPKEKKGRKLSTSRADEIVPDTSSALNCTSFQECDDSDQGTLSSNEDLDGEFCEFIHDAQLYGQMAADTFSVHRFQKLAFPDLYGAKGHSKRMENLVSRKFGVQRMKIFEDIDRMIHEQYLVDRVVYDLDRIIAEAGDSYCGSKSNLSNRDELRVGYIDQHSEALKFNAQFECGNLRKVIQVRQHEYDLILSPDINSNHHHQWFYFEVSNMQSNVPYRFNIVNCEKLNSQFNFGMQPLMLSVMDSIQGNPCWTRVGNDICYYKNHFIRNPNTTGGVKGKSYYTATFTVTFEHSGDICYLSYHYPYTYTQLKTHLCQWEKTLDSNLIYFQNQVLCKTLGGNDVPVLTITAQPKGVDRESLEEFRSRPYIFLSGRVHPGESNASWIMKGTIDFLLSRKPQAQQAREMFIFKIVPMLNPDGVLNGNHRSSLVGEDLNRRWAKPCSILHPTIYHTKGLLLYLNMINKTPMVYCDYHGHSRRKNIFMYGCSPAQSWIANDTQNPVCTNGKMNDTSFKALPRLLHSSCPSFCQQNCSFVVERVKESTARVVVWRHIGVVKSYTMESSYCGCDQGKYKDMHMNTSMLEEMGHKFCETLVRLARLKGAYDQQMPNLDPDSGLTGAMAEEYGDDLAAGTSRVFQGKDDPLNMESLLNASESDDDDDDEDEEEEFDDDLLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEM1</accession>
    <name>A0ABM0JEM1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat, SAM and U-box domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101846268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091969.1">
        <property type="nucleotide sequence ID" value="XM_005091912.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846268"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="390"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="465"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005091969.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="57863" checksum="E32F7EF19E2F5E6C" modified="2025-10-08" version="1">MFVSRPQVFHGEDYRTSSVMTDARIRAPCSLVASNTHTITTHTSDVTCLAFSATVLATCSSDRSVRLWGAKDFSELASSPMLGHTYMIHCCAFSPLGSVLATCSTDGTLRLWDVKTGETTAILAHPSKCAIRVCQFSSDGKLLVTGGDDDTVCLWNVADKKLVRSFKGHDESVMAATFTPDGHYVVSGSSGGDLGGDLLVWDALYGHGKALKRVADCHDLGVACCQFSPTYGSAGQPSPSGSVRQFLLATGGKDNLVKLWMFTAEVGSVNVTVILDTMLPGHTDSVLWLAFSPDGTLLTSCSLDKTARLWNVETKQTLISIDGHSSYVTSCAFSSNSKCLATASNDNTVKVWQLNDTSDIMTEGLSGYEQGEEVDSLAGGSFSKVAMETWSVEDVCHWLVSLGLAQLEDKFRDNAIDGRELLGLTGEDLRTSLDVAALGHRNKILRARTAVQRHPIGGGRSEPADTPEEFLCPITQEIMKDPVIASDGYTYDRPAIVAWMGRGDQRSPMTNVQLNSAELTPNRTLKMMIQKFLQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF76</accession>
    <name>A0ABM0JF76_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Voltage-dependent calcium channel gamma-5 subunit-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005092324.1">
        <property type="nucleotide sequence ID" value="XM_005092267.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848725"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008368">
        <property type="entry name" value="VDCC_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF0">
        <property type="entry name" value="STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01792">
        <property type="entry name" value="VDCCGAMMA"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005092324.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33043" checksum="15BD2E35774F6BAB" modified="2025-10-08" version="1">MPIEAEEFTVRRTNRRNRDVCSAFIMTCVSVTFGAATACSMVLAVATDHWLFTSEPYFFTAEERSMMNLTDLSSIPKVPIHVRSGLWRVCTVNILNGTFPDQCISIDYRQPGSGRMEGARTCMAIVGAIRYSTPMFVGGLVLVAVAVVLHFVGTLHQDVKTVISAVLYIATGLSLAVGIIIYISAINDEVGYSFRNRRHIDFEYDYGWSFYTTCLAFLSAKCSAVMCISQYLKGKHRMQDMVQIIPGLEEKLEADKSRDETEPPDCRSVRVWGSRKCKDRDKLIGRLNRSGLWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH02</accession>
    <name>A0ABM0JH02_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome c oxidase assembly protein COX15 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101855472</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005093477.1">
        <property type="nucleotide sequence ID" value="XM_005093420.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855472"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005093477.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47132" checksum="C45D8C3DA8BA1E31" modified="2025-10-08" version="1">MALLLRSFVRAPTTFSSCTGCLQTFKSHSLTSVRNFHQFKTYTSKQLNLALRPAQVSLLRKSTNVAAAQLSARSQKIVGSWLVGCAGMCFGAVILGGVTRLTESGLSMVDWKLIKDMKPPQSQAEWEEEFETYKQYPEYKYMASHKEMTLSDFKFIFYMEWGHRMWGRATGMVFLLPALYFLRKGWVSKALKPRLAVYAGLLGFQGFLGWYMVKSGLQDKPDPSDVPRVSQYRLAAHLGSAFLLYTLFLWQGLTHLLTPVKLQEVKSIARLRGMAHGVMTAVFITALSGAFVAGLDAGLTYNSYPKMADRWIPDDLWAFAPKWKNIFENPTTVQFNHRHLAESTVALIGGFWFLARKAPLHPRARLAVNLLLGMAFGQAALGITTLLTYVPTPVAATHQSGSLVLLSLAVWVAHELRRLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHV3</accession>
    <name>A0ABM0JHV3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852678 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093997.1">
        <property type="nucleotide sequence ID" value="XM_005093940.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852678"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047473922" evidence="1">
        <location>
            <begin position="26"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005093997.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25327" checksum="43B6FAA7A98FB125" modified="2025-10-08" version="1">MFSVSTKYVSLAILAIFSVVGTALASPVSQPTIDNPCRITSSAPPEYLPLQEEIALTLNVLETLRSSCEDGVTTMNTENLLTSDEIDMLMNNPMYNLPGLPLATATRNVSEEKMASILLEDYHDVSVFTVFAQQVYEEEDGNEVLKADLLKVKHYFYSTLCKLDTILGSINSPVSDFVSSDVMPDSLKNITSDKYRYMRAILLLNSAMKHIEVLHKDYEKLPQNVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI03</accession>
    <name>A0ABM0JI03_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101850547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094075.1">
        <property type="nucleotide sequence ID" value="XM_005094018.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850547"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="9">
        <location>
            <begin position="63"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094075.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38096" checksum="F402B4735E6F000E" modified="2025-10-08" version="1">MSLDTGNFTEDANGTSVTTPPNIWFPSEPNLPSYNVTHLVPRGDAGSCDVSTKYGIMAGIMAVVCFMFGVLYTFFGYRFFKAIMFLTGFIFGTVLVYMILEEHAVLPPWGTLGVGVGAGVVLGLVTMLIPHTGLFLTGFDLGVAVGGLILVLVEQFVHPSTKWIPISVLVVLGVVFGVVGLRFQRVVTIVSTGVLGGALALAGVDYFVELSRMSRYFWDRVLAHHSASPCWYSWLMLALWPCLTFAGVLVQWRFTGSGIDHRIALRSRTEQGANLQHARAREKRESQQTRYRHLYQARRVKGDVISQNFIQSIQHKLSPAMQSLTALNVEPNEEESTATTTLTQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI84</accession>
    <name>A0ABM0JI84_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Indole-3-acetaldehyde oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101846635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005094236.3">
        <property type="nucleotide sequence ID" value="XM_005094179.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846635"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="13">
        <location>
            <begin position="230"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005094236.3"/>
        </source>
    </evidence>
    <sequence length="725" mass="79458" checksum="19C21DBA23A8B550" modified="2025-10-08" version="1">MATKEMFKRPGDPHDISFYINGTKHEVSDKFPPTTSLNDYIRDVAGLKGTKVMCKEAGCGCCAVAVTHAFAGDKMETMSINSCLCPLYSIDGWQISTVEGIGSQRDGFHPIQERIAEYNGTQCGYCTPGFVMGMYGLLHKDSKPTQQEIEDSLDSHVCRCTGYRAILDAMKSFGSDATSPGAKCIDIEDLNMKLCPKTGDVCKREGGTGCASSSKADTHLKGHAPTPLTIDLRGSKWYRPLCLADLGWILRQHEAQSTRMVFGNTGAGIYKHEGPFEIYIDLRAVKELHKVEESDTSILFGAGTTITKFKDYLQTVQQKPGFHYSSRVVRHLKVVANVLVRNAGSMAGNLMIKHKHPDFPSDLFTILTAIDAQVDIFDSQSSQTTRHSMMEFLKEINMDGKVLVAVEIPALGEKDHYRSFKITPRWQNAHAYVNAAFKITVDGRRVVGKPNCVFGGLNSETVNVTAAEDFLKDKELNNAVITQTLKILYSEIDPSCDPILSSPNYRKNLAVNLLYKALLEIYKPSKLSLQSGADSMERPLSVGLQTFQEKPEDFPLKKPTPKVTAPLQASGEAVYINDIPTYQKELHAAFVISDVGPAKIAKVDASAALNIPGVVNFLGAADIPREGVNNSVPANPLLQWTEELFASEVVEYAGQGIGIILAETQALAEEGARQVQISYEDVQKPIVDIEEAIEKNTIFESATQERIVGDPEGMSTAIDSEMPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIT9</accession>
    <name>A0ABM0JIT9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101859774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005094645.1">
        <property type="nucleotide sequence ID" value="XM_005094588.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859774"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094645.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53672" checksum="C8173B27ED895B6A" modified="2025-10-08" version="1">MEFSCRLKSCAHPHPLSSKSARVEVKSALPRGGLRKVEDKLAVRWKKNGEAVFHPACWQRLTEAASQQKRKKRVKKKTVKKDKALGMSGASPTTRDNLGAHVIECERVMIQEASKTEEIFDSEEDVKEQAKRVALMIKSAKHCVFFTGAGISTAAGLGDFRGKGGKWTEEDRETVTIDDVEEEDLGPPPVKRARSVGKKNASSMSKNQSQGTAASEDKIEKEREEDDDNGNEELDYEHLRPTFTHEAIRRLVDDDHIKYLISQNCDGLHCLSGVPSSRISELHGNVFNEKCEKCGAMYSRPYYVCDDIGDMYLEEVADFGKSTIIAPKFMKKCRKCGLSHRTGRQCDVGGCGGQLIDTIINFCDDLEADILDKAFASAKSCDLLVCLGTTLTVTPACNIVHHIKKPRRIVICNRQVTEKDEESLKLGRDGTPLGARIHGDCDVFMTYVMKNVMGEEAYDAFVASLPERKAQYDEQRSKPSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJA3</accession>
    <name>A0ABM0JJA3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101845765 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094941.1">
        <property type="nucleotide sequence ID" value="XM_005094884.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845765"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045861598" evidence="2">
        <location>
            <begin position="30"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094941.1"/>
        </source>
    </evidence>
    <sequence length="1153" mass="132261" checksum="6318A35B9E6E3631" modified="2025-10-08" version="1">MRVARLSGRMSGWSCACVLLVALMVAVVASEVSGADQQATNESPSPTGAEDKDLLIPSKAGKDNAVTSPEEDTGSSADVSQESRELQTSDSSASKMAAGEATPGGSDVEDKDTETQPEDDNETDNEDSNSENSAQQQQPEVDKSSSSDAGELSGDLVGKRDVSGLVDDKRFLRGFNQFARRSGVDAVPSDVDKRFMRGFGKRFMRGFRSDNDGEAEKRFMRGLRDSLSASSPNDESDSFWKWDSYLNVPNHMDNLLPLDFSTPDSGPGADKRFMRGFRNYVTSGEDEKRFMRGFHKKDPILAGDISDVDLAEDKRFLRGLNNYAKKDSLDVDGISDSADKHFMPGLIKNSSSSSSDNVETSPDKRFIHGLQLYSRSYGGLGDSPVEEKRFMRGFGKKNEVYSDEEDLQTVADKRFMRGFNKRFMRGFGGKRFMRGFNKRFIMGLNNYADKRFMRGFQKKEDAFSESDDEIVDDKRFMRGFGKRELVEGNDDEKRFMRGFGKRDLIGDDTDEKRFMRGFGKRELVESLGGEDKRFMRGFGKREPVDDVTDDKRFMRGFGKREPVDDVTDDKRFMRGFGKREPVEDVTDDKRFMRGFGKREPVDDVTDDKRFMRGFGKREPVDDVTDDKRFMRGFGKREPVDDVTDDKRFMRGFGKREPVDDVTDDKRFMRGFGKREPIDDVTDDKRFMRGFGKRLPTEDDTEEKRFMRGFGKRLPTAETENDTEEKRFMRGFGKRLPTEDDTEEKRFMRGFGKRLPTAETENDTEEKRFMRGFGKRLPTEDDTDEKRFMRGFGKRLPTAETENDTEEKRFMRGFGKRLPTEDDTDEKRFMRGFQGKRFMRGFQKKADEINELEKKFMRGFNKRSAGEHQRTKREVRYADVDEGDLVEKLLEQDLFGEPKSEKTELWYDEPIIYPGEVNNEKRFMRGFSNYAKRGGSSLGANFEVGDDIVNDGPVNKRFMRGFQNFVNMARRRYSYPREGDSQDKRFMRGLSAYKRGAGGDSLDEDISKRFIKGLERYALPASKRFMRGLQNWQKRNSLEGSGADKRFIRGLHLYHKRGGDMSSVDKRFMRGLNLYAKRYLGWDIPDSKNRFPASSVSVEPVLEVSQEDGPSSVWEGEYDQPKRDYMFTSSLGNSSPKSGSRQFMSWRGGDYVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JL83</accession>
    <name>A0ABM0JL83_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Y+L amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101852315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005096330.2">
        <property type="nucleotide sequence ID" value="XM_005096273.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852315"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005096330.2"/>
        </source>
    </evidence>
    <sequence length="490" mass="52227" checksum="18BD5E57A55A6051" modified="2025-10-08" version="1">MTEPADTETREMSDVAAESHDVTIETKVQMKKELGIPGAVSMVVGNVIGSGIFISPKGVLRASGSIGLSMVVWLIAGFLQLGSALCFAEMGTMIPQSGGAYTYIRKGLGNFFAFFIMFKGVIIHSPASKVVILMTCSKYLVTLLPTCGSPRVVEKVITATLMLTLGIVNTYSTRYSARIMIVTTVAKVSALVVIIIGGFIVISQGTVSELGSGFQGTSQDPSALALAIYSASFAYSGSESVNSVVEEIKRPSRTLPLAAIFGVIAVMAIYLLTNISYLAVMSRAELLQADAVAVLWGDRVLGKMAVIIPITVVISTLGSANTSVYHSSRISFAAARDGNIPDALSYLQVGTLTPLCAMIVDMTLALVMLIPADIGTFINYMGFLNSVSDALVFIAFIVFRFGSMRNAHRPVKVPILIAVLMVLVSVYLFIAPLALSPKMSYVYVTAIVLGTTLLVYVPFVACGINVPLYDRVVTWVQLTLNVCPPAKFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNS0</accession>
    <name>A0ABM0JNS0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098000.1">
        <property type="nucleotide sequence ID" value="XM_005097943.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862944"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098000.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="43745" checksum="70C44DEEF4DF54B1" modified="2025-10-08" version="1">MEIDIQNELNRDGIVFYSVLYSSVTVIFAFAVLSKFLTNEFRFGFRSFLSLVTLFLGEPLCQFLVEGPSGLVVFSLGCLIIYYILPASHLPIKNRSVLITGCDSGFGHALTIKLDSLGIQVFAGCLEDRGPGALELKNRCSDRLHILKLDVTNSKDIAEASNYIKSRVGEEGLWGLVNNAGVWCFAELGMTSETIVQKVMDVNLFGAVRMTRAVLPLIKQAQGRIVNVSSLLGRISVEGCGAYSMSKHALVAFTNTLRMEMKKWGVCVSLVEPTGYFTGVMQEHSLQRKKEELWSALDEETRQIYGKEYFDSAYAHILTHAQSYPRDLSPVIRCLRSALLSKRPRERFPCGGGAEILMCVYPLLPVWMADCVSSSINLVPKQLRPQALSGMTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ57</accession>
    <name>A0ABM0JQ57_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101862415</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101862415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005098945.1">
        <property type="nucleotide sequence ID" value="XM_005098888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862415"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="186"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005098945.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26401" checksum="E3AEDA8A228BE371" modified="2025-10-08" version="1">MAYFHDTELLILEIRKRPVIWNCSLDDYKNKIKKNDAWAGVCRALQPNFDAQDDVTKKQTILEIKARWKSIRDTYTRSQKKIQRKSGSGATKTRKYMFADHLAFLRMAPSSRATEDSLDFVSIVSRDQSPDGHKVEQVDEEHEGLASESQSPSPAPSCGSVGPQSKSRKRKLEEKMLTFIDKCDKPDDDREFFSSLLPAVKKLNEDQKLTFRVDVIRALQAAKAGGQSGSTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRB7</accession>
    <name>A0ABM0JRB7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTMP kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101846818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005099718.2">
        <property type="nucleotide sequence ID" value="XM_005099661.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846818"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005099718.2"/>
        </source>
    </evidence>
    <sequence length="166" mass="18946" checksum="6E93965184E04D5C" modified="2025-10-08" version="1">MIDSYLKQSVELDDHTIHLLFSANRWEVFKKMKDLLLSGSTLIVDRYAYSGVAFTAAKGLDVEWCRQPDVGLIKPDKVIYMMVSGDCASQRSQFGEERYEKLDFQVKVKNVFKQLEDPDYWQVVNGDVSVDEVHSQVYQIASETINGASEKPLLKLWTDGTVSQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRE9</accession>
    <name>A0ABM0JRE9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UHRF1-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101864148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099788.2">
        <property type="nucleotide sequence ID" value="XM_005099731.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864148"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026728">
        <property type="entry name" value="BLTP3A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774:SF11">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24917">
        <property type="entry name" value="BLTP3A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005099788.2"/>
        </source>
    </evidence>
    <sequence length="106" mass="11973" checksum="680A539D8FD6213A" modified="2025-10-08" version="1">MAGLIKSQILKHLSKFTKNLSSDKINVSTFKGEGELSNLELNEDILTQLLELPTWLRITKAVCNRVAVKIQWTKLKSQPICLYLDEIIIETETCEQPRTPSSSEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS15</accession>
    <name>A0ABM0JS15_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101862952</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_005100209.1">
        <property type="nucleotide sequence ID" value="XM_005100152.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862952"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="63"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="195"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005100209.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="34987" checksum="50A47628B442B841" modified="2025-10-08" version="1">MKFRRFKRIFIKNTQPKALLALCCLTCMAMVLLSRFFGVPRNPDHPHNYIQYFPHREWRSSGAKTILLWTPRFGYDYWAMDPDYDFGECPVKTCRLTNDRTLLDTSDAVLFHSRALWNNFLGTSLPTHHQPHQVWVYQEMEPLPHVFLDLGHYKGVFNWTSTYRLDSDVPAVYSKLIRHGEPWLGWMEETDPAILWLTGALDERRRERIVNALSEFLPIDRYGRCGNLTLDCPQDFLCEKSLSQYRFYLSLENAVCTDYVTEKFFLPLQRRQIPGEVCEPLEDVKGDRYQVRFVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS90</accession>
    <name>A0ABM0JS90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Filamin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC101854724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100345.2">
        <property type="nucleotide sequence ID" value="XM_005100288.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939034.1">
        <property type="nucleotide sequence ID" value="XM_013083580.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939035.1">
        <property type="nucleotide sequence ID" value="XM_013083581.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854724"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF13">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100345.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012939035.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12504" checksum="54CBAC74F33B0491" modified="2025-10-08" version="1">MTSESDIIDLKARSREGRGLSQKAGEHWIEIQKNTFMNWVNLQLQSSGLSVSDFEVDFDDGVRLCALVEALQNRKIGRINKKPINQHQSLGNVSIALKAIADDNVRLVNIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSL1</accession>
    <name>A0ABM0JSL1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FERM domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100537.1">
        <property type="nucleotide sequence ID" value="XM_005100480.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857881"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051594">
        <property type="entry name" value="KRIT1/FRMD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057096">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283:SF10">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283">
        <property type="entry name" value="KREV INTERACTION TRAPPED 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24522">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="35"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100537.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="50376" checksum="F1883654E7D7F204" modified="2025-10-08" version="1">MAEKKQKRKRVDNENGDAGEHNELLALAANPEEAMNLVVFLRDRTGVHFSLEEAYLTRTDSLLHLVIHEQGLPAEAHNVFSLWLVSPLMDIRLKKQHNPFDVVQKWDELCARYTDATNDEIHESEPVLMVQRDVFFRKEQEQHIQNEQILCLLYQEAKYNVVEGRYVLHSEDYHYLAGIQALIHLGSFDPQQHILADYRANLVQFYPEHMFCQSRFAMFSLNSTQPPPCEELFMDAHRKASEELQHIASSDSVAQLYRKYLELLWTYPFYGGAFFSGIVEAKMPKWRRVLLPSQDFRVNICINTDGITLFNKEKCEFLLYVPYSQLSWRYQDLEWDGDSDPPPTLMLQFLCNEQCDEAPGQPVTKLLQIYSREAKLMDALIETCVKRKLELQKLGGDTDLVDGGLSDAAEKKILNKLEKLCLETYTVEGDQLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU28</accession>
    <name>A0ABM0JU28_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin domain-containing protein 12 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101513.1">
        <property type="nucleotide sequence ID" value="XM_005101456.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849471"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF11">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101513.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19339" checksum="A798922094476A98" modified="2025-10-08" version="1">MASYLTQAANLVFGSLSAATEYARGWGRNIQWVSMKEGQRLAREQNKPAMVVIHKTWCRACRALRPRFANSRDIEKLSNEFIMINVEDDEEPKTSEFKPDGGYIPRILFMAPDGKVMTHVQNQKSTGYRHYYPETTSILDSMKRVLKQTGGNPNVLETVRPRSTSRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU69</accession>
    <name>A0ABM0JU69_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein unc-93 homolog A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101862282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101572.1">
        <property type="nucleotide sequence ID" value="XM_005101515.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862282"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005101572.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="60120" checksum="A1681084DFD416D3" modified="2025-10-08" version="1">MELVEEEDEEPEVKPHRKRVNFRREMLRYQSLRNPISESHIPAPDEEEEMEDKEGNIWRNFVSQCSATFLAVFAVIPSRNLQTSIHSDGQLGKISLVCMYFSYIVGCLLTSLILRKIRAKSLLLISLFFHILYSVSNVIPSAYTLLPASCFVGLSQPAFWAVQDSLLLNYGLQYAVRARLTPHKSLRLFQTVTIITIHSAQILGNLLSSGLISVSEFHCTESWDIVNTSSSHQSSSSSSRSSGRQQQRNDKWTYTLPFIPIQARRSTEPSPPVNFYQLLTLIYLCMSVVAMGAVLIFFESPDTVLQRRVISWRERFKDIRRCLTDPRWLLAWAAAAYVGFAQGVIMCDITKLYGTDSMGCYIVGYMMVSFGTGNLLAILALDKLRLCATHPIFLSLGFLMNIGVLILTSLWKPGPSQSSELLLYTAMWGLADGTLQAQSQAVVTRYATEEKDTAMTGFRVCQGLGLIASFLSSIFAHNLMTSLYVALVLLVMGFLGLIFVANDIARRDRTSGTDQGSTDGQEADHSGANLTTENEAEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVM0</accession>
    <name>A0ABM0JVM0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgin-45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102586.1">
        <property type="nucleotide sequence ID" value="XM_005102529.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856441"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027095">
        <property type="entry name" value="Golgin-45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066">
        <property type="entry name" value="BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066:SF2">
        <property type="entry name" value="GOLGIN-45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005102586.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="50765" checksum="E2A8AE605A87133E" modified="2025-10-08" version="1">MSSTPKAKTNSGAAGTVLLRQAQPKYNFQGRKLPKETPGNKNNSDSSSDAVIMSSQSLSASNSMRKGGKPVAVVGAQTNSSSEKSHEAKTQLVAASPISSVSSMPNLTPGTNSSASGYIPGSGHVAGSDSSKDSHSSLGMSSNQRTSLPVSASFSSQPDFANMQNSNSTVRQATMGTGDSLPSLEASHAQTLAVQVLQNVHSGREQLEAVERERDSLKKDLEVQLQVNAELKKLLVASVGEDLSQRVERLARDRAQLSMDIGGFSKKMSEDHENFDKVSIQADMWRSKYLASRVMVEELGNARAYYALQSHDAQDALQQMLNERHELRTNLLENYKVLQQVKNAFDPLNSQRSSSLASTNVLDLSRACQQLSEAVRFRLLPAHVAVPVGTEGDEDLWENAVTRAEQYAHVVLSRPCEPVGSIQSGSSHLLPVMGSNTQGCQINRFHPHTRHENLTFNCCTKCKGDINVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWH3</accession>
    <name>A0ABM0JWH3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Nicotinamide riboside kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC101849306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103154.1">
        <property type="nucleotide sequence ID" value="XM_005103097.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012940690.1">
        <property type="nucleotide sequence ID" value="XM_013085236.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849306"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005103154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940690.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21899" checksum="6BE1BFA817C4F145" modified="2025-10-08" version="1">MSSKKFFIIGLSGTTNSGKSTLTSMLQSAFPHAFTMCQDSYFYGPDDPRVPLESQGFQNWECLGAMDMEKMVAHVNSWMAKQESNKTPALLIIEGFLIFNHRQLSSLFDQKYFIKVDYSTSAKRRVFRTYVPPDVPGYFESVVWPKYLQNLEDIQDQTQIEYLDGSKSLDDLYNQLVQGIKAVLSGDKKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXM1</accession>
    <name>A0ABM0JXM1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101854591</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103935.1">
        <property type="nucleotide sequence ID" value="XM_005103878.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854591"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046530338" evidence="2">
        <location>
            <begin position="19"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Apextrin C-terminal" evidence="3">
        <location>
            <begin position="252"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005103935.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="51354" checksum="CC15BF8F50FBD353" modified="2025-10-08" version="1">MPGQRLLLLLLLLPVAQSWTRGRPPVYVDLQPNHVIVQPGVTEMFTLTCTVTRGSYKVLENPGPTSRAPDFSSIVKEHLVRVRLLRAAIPGPTQSAWEVVAQQTDTDPKATTFEDGVVASGKVIPESRGASYLNVTWFLAQPSTIGTFVCDALVVARDSAELIRSTTLEVGNELMGEDFSRMLEVGKADILSDALEENKALKEQLETLTETVRQTLAEHRETLAMIESKYRRILETGFLGTGFLETGFLLHWPSGSYALLGPASGCPKDDASTWEKGFTKTHTESEDRNHDQVSELSHLRGPVLSREDGDHFVTQHFCVKTSILSFGSNWPKGSYCINKKGGCPAGFQEGRIYWDTEDTEAKFRSSGNLPDGDHGANPNLHYCCRDDGSPDDEIYLPPYQPFYLYRRGGRCQKVHGMDVTQEFLLFDTENSRNGDRTENVVPDSQTNDIRLELCYYHNSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY08</accession>
    <name>A0ABM0JY08_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain-containing protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104210.1">
        <property type="nucleotide sequence ID" value="XM_005104153.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857426"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18493">
        <property type="entry name" value="BACK_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056184">
        <property type="entry name" value="TRAF_BTBD17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF41">
        <property type="entry name" value="HL07962P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23651">
        <property type="entry name" value="TRAF_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104210.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="58155" checksum="58C7CBEBDBAF1665" modified="2025-10-08" version="1">MAGAGEIIISNASGLSFRLQSLYQSGDMCDIQINVGKKTFQAHKLILCASSDVFKTMLTSVRWTEANKQSIVLVEDRSCETIFDRFLHYIYSGELFVSHATVGPLFILADKYNIRDLIPLCRRYMLENLDAPVDDLSVLQWWQIANLHRDFELQEKTLSYIELNFSKVIQTTDFLNANVHTLNILLSSSRIVIPNELMLFYGLKHWLEAYIECSCSSLTVRELKKVFKELTRHIRWPMMTKDELEWLQEDSDMQQFIATYRNFMYLPSPEDLELDSTDEPGISDPWCFVAEFTDRHCLNVEPRCSASPKSDLKKRKPRKIDNGICDKNRSAASRVYLSDHWSSSLTVSDFAAFPRYGTRTFFFSTPRTGFRRDTSTLDWEVEVHPKGVHFQPAILIGLERDGNKVVDETFVNTVRVSVMSRSPAELPVKVEVNILVQASSPSNPDCLYIERCRRQVCIFDSSSSRHNLDDIVPQENMGVYLQPDVHFPGLAVSPTLAFSLGIVIRPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY41</accession>
    <name>A0ABM0JY41_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibrinogen C domain-containing protein 1-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104278.1">
        <property type="nucleotide sequence ID" value="XM_005104221.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853403"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047157642" evidence="2">
        <location>
            <begin position="23"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="334"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005104278.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="62277" checksum="7C1656BC38BCC7E0" modified="2025-10-08" version="1">MGPDVISGYILLVAAILSSCDALVLHGTTAEVEIWKTKNVSLECMDNDQQPDINSEVIMMRILKKDHDGWSCFAELRDGEAEVTPKRKDVLAEANKTSISDSFLRLTWPVATDDTTGEYRCDFVVLTSQENFIFKKSQPTLISRKSNLTVQILNKIMEENKREYLQRLRSQREIILENVTVMAEESKTQCMQQKDDILQNFTAIVESFGASFESKWKGQLQVLSRTVDQNKRECPHQMLSQKRQILEHVAAIMEQTKEEIVQQKEDILINVTAVAEQAAKREFAEQREDLLNRVTATTEQTKSELVQQEERILNNLTAIVEALEANFERKLGDLKIKLQPKSCSEAHDLGPRPVIVLSDGMKVVCDTVTDHGGWIVIQRRASAAVDFYRDWADYKNGFGDFSGNFWFGLEKVHQLTSQDKYELRIDMKYEGDDYYAKYKNFKLSGESEKYKIQLSGFSGNVDDKMSYHDGQEFTTKDQDNDFSSSVNCAVDRHGAWWYDSCHYVNLNGYWGSKRLKEGMNWYGLTGEDDSVSFSEMKIRRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K054</accession>
    <name>A0ABM0K054_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847361 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101847361 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101847361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105637.1">
        <property type="nucleotide sequence ID" value="XM_005105580.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105638.1">
        <property type="nucleotide sequence ID" value="XM_005105581.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847361"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021122" evidence="2">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105638.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="13374" checksum="8696F7F358449D7B" modified="2025-10-08" version="1">MNAKQICALLVGAVLLVSVCAAEENRLKRHFFLGGILGGRPPYYRYPFPNNPAPIPVNNPATGTNPGPAVGPPIGQPTGNQPTTTGNQPTTTGNQPAQGPVTINLTAQQAQLLRSILAFLLNGGAAPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1D2</accession>
    <name>A0ABM0K1D2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase MARCHF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Membrane-associated RING finger protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Membrane-associated RING-CH protein V</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase MARCHF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101859194</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005106458.2">
        <property type="nucleotide sequence ID" value="XM_005106401.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859194"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16701">
        <property type="entry name" value="RING_CH-C4HC3_MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="14">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005106458.2"/>
        </source>
    </evidence>
    <sequence length="296" mass="33517" checksum="3821F3CF07B06047" modified="2025-10-08" version="1">MSYSRLQSDQDRRSCWVCFATEEDDRSAQWVRPCRCRGTAKWVHQTCLQRWVDEKQKGNSTVKVACPQCNTEYLILFPKLGPVVYVMDIIDRVIYKMCPFVADGIFIGTVYWTMVTYGAVTVMQVLGHKEGLNVMEQADPLFLLIGLPTIPLMLVLGKMVRWEDYVLRLWRKHSSKLPLLNYLFPDEHSRMSRVPADTVTLTDPISATRVLCGALIMPTIATIVGKLMFGLVQSNFQRTLLGGIAFIAIKGVLKIYYKQQQYLRQANRVIKDYEEVGESSATATPTSEDGAATNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1M4</accession>
    <name>A0ABM0K1M4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860684 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106634.1">
        <property type="nucleotide sequence ID" value="XM_005106577.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860684"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106634.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44628" checksum="F58E246E7B2A5684" modified="2025-10-08" version="1">MDDYFRSCAERARTDDSCWSRRRVYVNSILCFAFLYGFYLLFNIAGARYVLLRLVTPALTDADERDVPNSQERLFFSAVGLCVIAVVVAFHLLVRESSHRETSETHGHETGIQCDGSSSISLAVDDVILGEENTKESTDNSSDKNVVCLGCDVILAHVKAEIAGTEPIPRKSASEDLVCKMRFERKNGCPAMDDNRIKEQEGPDKSSHVAHSVTDLQGTAQQNTSESSVQTDGLGLHETTVSVTETSFCSIATMTEVPEMVDAAVNTQQLRYKSFRNSGTSTSGPFLKKLRRAQRLLHEARWRTARDRKRKILEWRAIMGRYQEKLLRLTQSLISKDHLIGYTVSTRKLSEEEVKVIRTTVRFSQDKLESQQKMNKKLETNIEEKSTATANLEQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1W9</accession>
    <name>A0ABM0K1W9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC101858663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101858663</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106799.1">
        <property type="nucleotide sequence ID" value="XM_005106742.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005106800.1">
        <property type="nucleotide sequence ID" value="XM_005106743.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858663"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="481"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005106799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005106800.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="74657" checksum="28A37D6035984024" modified="2025-10-08" version="1">MGSKKKGRKKRHHKKVTTRHAPVEEPASENTCLRRASSGGASYVVVNDDSSSSSSGKMTECWAESETKRKDSGTECSRENECVDFPEEIANNEANSGTMRYDLGAECSIENELVDILKEIATKKVTSGTMKNDSGAECSRGNELVDFPEEMANNEANSGRMRDDLGAECSIENEWVDILKEIATKKANSGTMKNDSGAECWRENECIDFLKDMTENEVYSETTKKDSRAEFSGEKESVDFAANIMTEEGVNNETLRKDSGAECSRANECVESLEELAEYEVTSETPRKGSGLESSRENTKITYSDVYGEDRYDEEEEIERKFGKTVYRKSEIDHRKDEVDIMASPCLSPPFGDRRWVQHKRWAPRKVITATRGPGVQEDLAVLGAKLDALHFARERRERQKRIVVGKRQENERKTDTAGGPVGAEEGGDSLDEQPIDMRKGHYVDEGRKGNKGKEFKREEKKRKQTKMVEFTGEEITNKVCVCCGKRGVMLPCSHCLWAGYCGQRCQQQDHQDHEKSCKNTMKFGAALREYLLDRPEVEIPGCYSLCDLNRLSSVVVSPGAVISKHVIAEIVCPHQHSFRPSVVIQDIHGAITFMVFYSDTEMYTSTEPTYPHLQPEVPVVPLKDCLVPGNFVVIHRPSWHYFSDTTVGFRIDNLTDVHFITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3R3</accession>
    <name>A0ABM0K3R3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-like protein 6A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108061.1">
        <property type="nucleotide sequence ID" value="XM_005108004.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856050"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108061.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="46838" checksum="287D9391368C394D" modified="2025-10-08" version="1">MSGGVYGGDEVGAVVFDIGSYSFRAGFAGEDTPKAEIPTHVGVLDDLEAAMETENGGDNNVTPKRYLIDTVYMKHPVKDMELTNFLKAGMIEDWDVFEKVMDYVYSHSIKSEAQYHPVLMSEAAWVTKGKREQLTEIMFEKYNIPAFFLCKNPVLSAFANGRSTALIVDSGATQTSAVPVYDGYVVGQCIVKSPLAGDFITAECKKMMTEMGIEVPPPYSIASKEVVGDAQPAKWKKKENINVTKSFHNYMVKDVLQDFAATILQVSDSPYDQAQADAMPTVHYEFPHGYNQDFGNERFKVCEGLFDPSFIKESGGNSMLGVGHVVTSSVGMCDIDIRPSLYGSVICVGGNSLLQGFTDRLNRDLSNKTPPSMRLKIIAASSSSERRFSSWIGGSILASLGAFQQMWVSKQEYEEGGKMCVERKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3Z8</accession>
    <name>A0ABM0K3Z8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 15">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100533212</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 15"/>
    <dbReference type="RefSeq" id="XP_005108216.1">
        <property type="nucleotide sequence ID" value="XM_005108159.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100533212"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008349">
        <property type="entry name" value="MAPK_ERK1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01770">
        <property type="entry name" value="ERK1ERK2MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="33"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005108216.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42570" checksum="D217C0E47BC03FF0" modified="2025-10-08" version="1">MAAQGSQAKSAGRNVRNAGEIVRGQTFEVAPRYTNLTYIGEGAYGMVVSATDNQTKQKVAIKKISPFEHQTYCQRTLREIKILTRFKHENIIDIRDILRAPTVEDMKDVYIVQCLMETDMYKLLKTQQLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLANRPLFPGKHYLDQLNHILGVLGSPSQEDLQCIINDKARGYIQSLPFKPKVPWNKLYPNADVKALDLLEKMLTFNPNKRITVEQALAHPYLEQYYDPADEPVAEEPFTFEMELDDLPKERLKELIFQETLQIQDKNLEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K483</accession>
    <name>A0ABM0K483_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">39S ribosomal protein L27, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108367.1">
        <property type="nucleotide sequence ID" value="XM_005108310.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846688"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005108367.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16793" checksum="6733DF53A8F2BEF1" modified="2025-10-08" version="1">MAASLLRKSVTGVLQVPRLATNFLFSKSLPVLAVEPARCASKKAGGTVRNKKGRTKKKYRGLKAQDGSFVHSHDVLATQYGLRFYPGENVLLDPDCTLRAAYDGIVVISTETLNPYPDSPLYAPTQNGLVLQKKFIHVIPTPLHGKFRLLSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5F9</accession>
    <name>A0ABM0K5F9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21 22" type="primary">LOC101858067</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21 22" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="RefSeq" id="XP_005109176.1">
        <property type="nucleotide sequence ID" value="XM_005109119.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005109177.1">
        <property type="nucleotide sequence ID" value="XM_005109120.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943926.1">
        <property type="nucleotide sequence ID" value="XM_013088472.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858067"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07902">
        <property type="entry name" value="Adenylation_DNA_ligase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07967">
        <property type="entry name" value="OBF_DNA_ligase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031916">
        <property type="entry name" value="LIG3_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16759">
        <property type="entry name" value="LIG3_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00347">
        <property type="entry name" value="ZF_PARP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 13 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="16">
        <location>
            <begin position="101"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="579"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="18">
        <location>
            <begin position="952"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="194"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="832"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="846"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005109176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_005109177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_012943926.1"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114624" checksum="42C538C27ED58F2E" modified="2025-10-08" version="1">MLCTSPVVVRRLHGSSFVSCVKVICSNSFVSKCQEKRFGVVETSSFQKYLSRYSCHDALCAKKLNGPTDFLAKRKLLSLSVPYSSHSISYSNIIIMADNKYVVGYAKLGTSSCKKCKQKIEKGALRIGKVTPNPFSEDGGDMKQWFHPACIFETFVRARATTKKIEDPEDAEGFGDLKPEDKDVIKKLIDEYLSKTGNKPSPKPKKAVQATLPGASPAKADAPSSSSDSAPSSSRTPSKPSTSSAADGEDPNAEKDNSFRQFRRLCADIAEENSYLGKTKLVKSYITKGHSGDGFQGNLYLLMKLLLPGVVKTVYNLNSKQLVKLFSQILATNLSRMIEDLDQGDVAETIRIFFEESKVFVPQKKSTLSLTEVDQYLSDLAQVTKEDDQQKVLTKITKRCTANDLKMVVRLIKHDLRINAGAKHILDGLDENAYAAFQASRDLGDVVDRVLEQQTGSGDKPGLKKKLSVRAALMTPVLPMLAEACRSVEQAMKKCPNGFYAEIKYDGERVQIHKKGNDFRYFSRSLKPVLDHKVKHFKEYIPKAFPTGSNLILDAEVLLVDTNTGNPLPFGTLGVHKKAAFQDAQVCLYIFDCLLINDENLMDRSIKERRKILEKNMSVVKNRVNLSEIKRITKPGDLQDLMSRVFKEGLEGLVLKDVNSIYEPGKRHWMKVKKDYLHQGSMADSADLVVLGAYFGTGNKGGIMSIFLMGVYDPDAGRWVTVSKCGSGLDDKMLETLNKELDMVKISKDFSKVPKWLHINKPLTPDFVVADPKKSPVWEIIGAEFSKAEIHTANGISIRFPRVQKIRDDKTWKEATDLPRLKKLFAESKEKADSDLMRAMGKGGDDDNDDGGSETEDDGDNSGEENGRNGDATGATRISTPGKKGEKRRASDDVSEESSPPKKQANPMGKYGASCHQKRGKHTEEFRHPESSSADTASSGGSSSQTAGSASGLPAVFHGCKIVLPSSVERFRDLKRYILAFDGDLLHQFEASSATHIVVAPGSEPPSVSSKVPRVSPRWLWSCIRRRQLVDTAPYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6B2</accession>
    <name>A0ABM0K6B2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell cycle serine/threonine-protein kinase CDC5/MSD2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109740.1">
        <property type="nucleotide sequence ID" value="XM_005109683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849501"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109740.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39662" checksum="7DD83E50AF5989C1" modified="2025-10-08" version="1">MESVAVPVVRFIAGDFWSSVKMRQVRVLCQKTTTPVQVLEVAMEDDDSVRKVIKRIGLTDRRGRDSWREVFKEISFMGNVSHPHIMKMDWAVRCKGFVAICMPLCSRGSLHDARQSLNSEQIERYFVQIACALRYLHVRCAVHGDVKPGNIFLDNSNNAILGDMGMSRFLAHGQDRVRSWSILGTRGFLAPEIMSDVTADPFLTDAYALGATLWCLVFKRNPRNWEDLLTAVESDSILLPRMGFYRFVLSRLVQNNPRLRLSVCDLLGFLRLRFERFRCLSYTTARNESRGQDAMGQLRAEGLEAKFHPLDITDHNSVITLRDFLHDNYQGLDILVNNAAIVFKIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6J1</accession>
    <name>A0ABM0K6J1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable serine/threonine-protein kinase CCRP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109919.1">
        <property type="nucleotide sequence ID" value="XM_005109862.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851449"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005109919.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35494" checksum="3BF131DCCE15165B" modified="2025-10-08" version="1">MLSLRPPVFEIHSNCLTEALSVSKNQLLGSGGSSQVYLVTDVNNPDNKKALKILSSLDDEDSEDEDNKLFLFETEVKILQDVRHPNIIRMERAVKCQDGVAILLEYHRSDLFHSLRKLSLMESFRFFIQLIDTVSFLHQHRLVHGDLKLGNVFISHCGNAVLGDFGQAQHLPEHSTSSERWGGSRPYRGPEFIKDATVEDVFKLESYSLGLCLWALLLRVHPEPGMDFLQKLKDAVSIPEVRRKCVERLLCPSPVDRATVVETQQLLIDHNLTEPCDPNAADRPRHSQIRHRYRNQAMKTVARPWKLKTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7J6</accession>
    <name>A0ABM0K7J6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9 10">U1 snRNP C</shortName>
            <shortName evidence="9 10">U1-C</shortName>
            <shortName evidence="9 10">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101859822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110617.1">
        <property type="nucleotide sequence ID" value="XM_005110560.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859822"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="12">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005110617.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="17866" checksum="998C3EB1CE5A9B5E" modified="2025-10-08" version="1">MPKYYCDYCDTYLTHDSPSVRKTHCNGRKHKENVRLYYQKWLEEQVQKLVDDTTAAYQAGKISANPFSSGTPGGPPSGAMVPPPGAPPPNVPKPPMMGPPGAPPMGPGPMRGPMPGPGGPPGGPGPMMPMMGPGPMGPMMPGMRPMGPPMGGPPMGMVPMGPMRPPVIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K803</accession>
    <name>A0ABM0K803_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18 19 20">Delta(14)-sterol reductase TM7SF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 19 20" type="primary">LOC101848155</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110968.1">
        <property type="nucleotide sequence ID" value="XM_005110911.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005110969.1">
        <property type="nucleotide sequence ID" value="XM_005110912.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828938.1">
        <property type="nucleotide sequence ID" value="XM_035973045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848155"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005110968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_005110969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035828938.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="65214" checksum="688F0BB7C06AA85E" modified="2025-10-08" version="1">MPSPKKSKSPARARTRARSKSASRSRSRSSGRKTKATAAKVTEVKEVVRTSSRIPTRRSTSKSPSRVRVKESSEKSVVTQSAGGAAAAASTVTETVVTRRTYVSSGSSEGQQKASVTPVRSSSRIASLIEKEREESSRIREQMKSEVMANIKTPEKSDSEERKPKEKAVHYEFMGPIGAFLLIFLLPLTVYYVNMACRKGNCSVLVIPKLPRNIVAAFLDVEVTLIFLAWIAFQALLAVLPIGRVVEGQPLKSGGRLKYRCNGFIAFVITLLTLGAAVYFKCPVTLVVDKFFKYMTAAVLFSFTLSICLYVSSFLVNKKKLASTGTTGNHIYDFFIGRELNPRIGPLDLKFFFELRPGLIGWVVLDWIMVVKAYQETGVWPPNLILATFFQTLYVADALWFEDAILTTMDIIHDGFGFMLAFGDLAWVPFLYSLQPRFLLESGFTLPWYCLAPIALLNFVGFAIFRMSNSQKNLFRKDPKNPALAGIETLPTQSGKKLLVGGWWGLCRKPNYLGDLIMALSWSLCTGFHHIIPYFYPLYFLVLLVHRERRDNEQCQQKHGAAWDRYCERVKYRIFPYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8H9</accession>
    <name>A0ABM0K8H9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DPY30 domain-containing protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111336.2">
        <property type="nucleotide sequence ID" value="XM_005111279.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861011"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22966">
        <property type="entry name" value="DD_DYDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049630">
        <property type="entry name" value="DYDC-like_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005111336.2"/>
        </source>
    </evidence>
    <sequence length="193" mass="21840" checksum="1A57C573CF1AC2A0" modified="2025-10-08" version="1">MVVNNNRMEARYLKENLGCLTACLSEVAEKRPHDPIEYIAFWLKKHIENERLIANKEEEAKQLEREKEEEALEQERRAKRLEEARQLSEEEAERRKAEEEKRQREAASASKLPVVEEKEEPSDGEAQAAQAEQAEQEAGQTDGTPPEESVTEPTVEEGEATTTEGEEAEKTEQEESAEATQEETSGEAGPTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K983</accession>
    <name>A0ABM0K983_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Keratin-associated protein 19-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111891.1">
        <property type="nucleotide sequence ID" value="XM_005111834.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852813"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046924347" evidence="2">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111891.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="14584" checksum="8CDAB3C7A8B06260" modified="2025-10-08" version="1">MKVASLTALLALLLCLSPATGFGYPGYGYGYGGYGGYGGYGGYGGYGGYGGYSLIHPGIGGYGGFGGLGMGYGGFGGIGMIGGGFGGGFGGGFGGGMGGLFLGEIFDDLMEEMENMVNDDDDNGDNGDNGDNGDNGDNGDNYDNNGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9U8</accession>
    <name>A0ABM0K9U8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcriptional enhancer factor TEF-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005112381.2">
        <property type="nucleotide sequence ID" value="XM_005112324.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846623"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016361">
        <property type="entry name" value="TEF_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002603">
        <property type="entry name" value="TEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005112381.2"/>
        </source>
    </evidence>
    <sequence length="365" mass="40972" checksum="6CD2A83FE4A8550B" modified="2025-10-08" version="1">MYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAKEIQAQLKVTVSTNLQDQAARDKALQQMASMSSAQIVSASAIHNKALAGGLGGLPPSMASGPVRPPYPGAPSIWQPGLSQGDVKPFAPAYGFDSKLPSSISGEMALPPWQGRSIAGPKLRLVEFSAFLEQPRDPDSYHKHLFVHIGSTATYNDPLLEAVDIRQIYDKFPEKKGGLKELYDKGPASAFFLVKFWGDINTNLQDEAGAFYGVTSLYENNENLTIEVSTKVCSFGKQVVEKVETEYARMENGRYIYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTRETLLCIAFVFEVSTSEHGAQHHIYKLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAB8</accession>
    <name>A0ABM0KAB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101856150</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112735.2">
        <property type="nucleotide sequence ID" value="XM_005112678.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856150"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045941273" evidence="2">
        <location>
            <begin position="27"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112735.2"/>
        </source>
    </evidence>
    <sequence length="297" mass="31785" checksum="D069465CF065B40B" modified="2025-10-08" version="1">MAAAKIPDVVLVVCGILLVLSGLSSGQTTEECTERYQNASAALTNLDQFCDITEEYVECILRAMHAQTLLTDAFVTNFETSIEAALGPLQLDCPIEFEQIAAMIRNSSDSSNNTSSEYEICVNTYASSLNLSAPRAEVCAVTQELYICTFDAINLDLSTLTELQMDELQAQLNQTLSDSGISCDFTIRSIAAAQGAGVSDAPTQPSPTPTGPVDVTTDISGTGRVTDGPVPSAEPTHWSIPDWTTRTGGVTNWPSPLTKPTLEPGHIHDGATVTSSLDTLMWGLVSMVIVLWRRGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUK5</accession>
    <name>A0ABM0ZUK5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859624</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934771.2">
        <property type="nucleotide sequence ID" value="XM_013079317.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859624"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012934771.2"/>
        </source>
    </evidence>
    <sequence length="109" mass="12702" checksum="F8806BB6610F4F37" modified="2025-10-08" version="1">MASKPSQLRLTYFDGRGRGEICRLILAHAKKNYEDKRITFEQWGEFKPRLFFFLQITLADIAIFDGSDWISMVKPEELDKYPEIKALRAKVASADGIKQYLAKRKQTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUN8</accession>
    <name>A0ABM0ZUN8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">39S ribosomal protein L37, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934820.1">
        <property type="nucleotide sequence ID" value="XM_013079366.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011061"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052482">
        <property type="entry name" value="mtLSU_mL37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012934820.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48405" checksum="B21D288E41B381F4" modified="2025-10-08" version="1">MRLTRKLCAGIRDVTVRNWNIQWQRHGKFNDQPVKVPPALVQKGVEIVDAKELLKRKAVPWSPPVADDLRWAEAVPPEERADWKTEPAYSFSHEVQLYEGMKQACLIAKAQHFEGLPPAVQELVGAVPTPDRDLLLQRLIMLSQCWNTDETRLPKRKAPPHKILWKFKRAYGITATKSSEILLRSLLRLCQSHVGDLPSLAARRQTYQPLLHSHVMYRDKAIVQRESLDCVVSSDSWLPPFAGEDALDESVAHRIPDMWPVLPTVDFTDIHNYELDSLPGFSRERQFGCPHTILQIGRSSEWSVGQCQASQLLTCLLYTAALARHKFGDNVRILPEPISIQHVSMQPTGFLLTFFQLNTLDLDNSEAGVKNLVWTADKCQLFEKILGQPWMPQPLKRDRLVHFDGAAFEPFLAAYLNGCPELASSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUX9</accession>
    <name>A0ABM0ZUX9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L18 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100533263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934966.1">
        <property type="nucleotide sequence ID" value="XM_013079512.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100533263"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046687805" evidence="5">
        <location>
            <begin position="17"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="41"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012934966.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26011" checksum="6DABF4A28E4418C3" modified="2025-10-08" version="1">MFRFVTLNFPALFVLTLKLSPLFNTTIRDVLPFSPKTGKMGIDICHKNDRKVRRTEPRSQDIYLRLLVKLYRFLARRTNSNFNKVVLKRLFMSRTNRPPLSISKLARMMKKDGRENKIAVIVGAITDDIRIHNLPKLKVCALRITERARGRILKAGGEIITFDQLALRAPKGQNTVLVQGGRKARKAYRHFGLAPGVPHSHTAPIVRSKGRKFERARGRRKSRGYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUZ6</accession>
    <name>A0ABM0ZUZ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase unc-51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101851791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934995.1">
        <property type="nucleotide sequence ID" value="XM_013079541.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851791"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="721"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="721"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012934995.1"/>
        </source>
    </evidence>
    <sequence length="1040" mass="114763" checksum="1669FD9FC79EB897" modified="2025-10-08" version="1">MLSETNIGDYEIIKGGVLGTGAFATVWKGRAKKNHDQLVAIKAIKKKNFLKSQQLLSKEITILKELSSLHHQNVVGLLDCVELKDDVCLVMEYCNGGDLADCLHRNGTLSEDTLCSYVKQIGEAMKALQQKGIVHRDLKPQNILLCYEGTKYPHPSKLLLKIADFGFARFISGEDMATTLCGSPMYMAPEVIMSVKYTAKADLWSIGTILYQCLTGRAPFQAQNPQELKKKYEKTPGLKPNIPSSTSPELRDLLMRMLKRDAEERIGFEEFFNHPFLKLSTGPKVSQPVSVPRRRSSSSSESSTPGKSPGRNSPSSRCSKRTCSPAPPPPPVSSKVTAEHKEEDMVTTLTEAAGFTKVEKEEVRTGRSTPEDFVMVPEALCIESDGEESVSVRKAPLAEAEMSFSSSTHRSPKSIRIQGKEAVTFSKEKDEKEKESLPSSPSRPVTLPMATPKTSEPITVPSEMKGTGEGSDTCVADGANSGVKRKIKSPDVRMQEKENQDRTVARRNSEARQSGLDTVNAGSFSPPAVQFCVGTPPGGGTGPSWKRSSVVTPPPYSTGNLTGSPHRRGSVTSPLFNPLQLSNPSLIQPPGSLPTILGSPNKMPAMFHLGSSPHDNSPEPIHAPFAAACMQQQQGTTTSSSSISSAVVAGSAPYHTSNTVPDNLVAMARQRDALNEIQPMDYHRVSTDSSLLSHQLHNQNRQGMYLTRVGFAAGPVVSYGSRERVSSVSSDKDRFGSSLEQDRSPSFVRRNSGIDMSPPQHLLVTHSPPRGPPPHHHQHQQTTTTAPLRFVPQPLSEETLMDDNHNETLGKLSFVLDLVECILDLARSLGSAFRSLDPSEAKKVEQLSPEHYSQYRSSQRSLEQLVLYARACHLLNSALHMARDEIRNDRLQQSTNLRNVLGEMNTYYHHVVDRCKSIHKEFSQNCKTPLTQKLVMATADKLIYNQAIQMCQAAALDEFSQTPSTDSMAEIVRRYQVAQILLHSLAQTARNENDKHMLVKYRKSVESRLSVLTREGSHFDRHSMSQYQQTVDNQRFQMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWR7</accession>
    <name>A0ABM0ZWR7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101861197</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936100.1">
        <property type="nucleotide sequence ID" value="XM_013080646.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861197"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012936100.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13669" checksum="B0D434BDEA73FCC4" modified="2025-10-08" version="1">MAYGGNDYDRGHPHPRPMQDPFRDRGNEDLEKFQKQKQDMEQDIQRMKERQMKEKMEREDEKKKVKYPLVFGFLVLITLSFSDVFNSGGEGSDDGEGDGDGDGSGGNCLVCLVNYFVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXV5</accession>
    <name>A0ABM0ZXV5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101859095</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101859095</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012936746.1">
        <property type="nucleotide sequence ID" value="XM_013081292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859095"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012936746.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35529" checksum="D7C189652AD00F0F" modified="2025-10-08" version="1">MTVSNATASSVQLTTAALLSLDRELTGIVGHEAREWFKTIVEVWICSILSALGVATNVLVIAVFTRQRFRDNISISMTAIAVWDLLKCVSGVLCRLYWAMGLEDPVLGEMWLEVPAILLSYLHSFMGFVSCALAAYVSMERCLCVSMPFKVKDIFTRRLTLIMMITISILVMSSFMVIFPLWEIKQVFDLDRNASTTIMVFSDFHSDFGVPVLRYYNIISVLWPLLSFIVIVVSAGVILYNLQKSSKFRGKNENMQEDGMSKRDLQVVKMLIVIIAVYIVNLFPRIAQYFARFFEPQFISACDIITFSLWLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYR0</accession>
    <name>A0ABM0ZYR0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101849611</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101849611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937299.1">
        <property type="nucleotide sequence ID" value="XM_013081845.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849611"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041249">
        <property type="entry name" value="HEPN_DZIP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844:SF1">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18738">
        <property type="entry name" value="HEPN_DZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZIP3-like HEPN" evidence="5">
        <location>
            <begin position="67"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="433"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012937299.1"/>
        </source>
    </evidence>
    <sequence length="1144" mass="127867" checksum="6637BFF110DE477F" modified="2025-10-08" version="1">MELPAIQENDQPLVNGHTTGQGKDEAPPEHLVTSREREYLARVCWLLHDVGTLALRTTFDSIHPPLSLPDHLQHVHVKTMLQKLHQQNILTDKQWRQLYPPKKKKKTRKVVCSRDFDTKVLVVLLQTVCHLTPPYPHGWHAEPLPADSSLSADVVRLQLKLQEIGALSGVRKEEYPVLWQQAAGVLQRLGGQEVHVKIQRIENEALPAEQSLHYIQLVKGAWAPGEAAVMMGKLRDLEEQRRRGSRGATSAYKRKEGGDDGIPPEDRVVITKCYKLFHDTVQAEDVLDRLQQGQVVKVTDRQEIMAPSKNVDRMQILLPKIMKSPISYAFKLLCDAIKFKYPRIYEQVMKTRKAVYKQGISDSIDYVGLSIEGLQAHYKEVFSKMRPLAWAEGEEVTIKDFFCQPEIVCSDGPKISLTDLLPPRSSASRGPRVVLEGFAGSGNTSLAAMMTYLWATQSDYFTNKYKFLLHLDAHAFKQSLDEEVYNQLLPPNFKMSQSEFWNLIENNARDVIVLLDGWEGGQGGPDISALVQGSILRSAAVLIFVRPEARVDSFVKPDYKLFNLGLSVSGISRCLGNFCHILDEPSDVSDDGSEAADVIAFPLESCQAISDLLKLPFCCTAVMAVYRVLGREKLETISSLTGLMEQYLVALAFAFCQNEGLEVQEQEFPEVVTRTISQLETLAFHSVSTKSLTFTDDDLVGVTSNPAVTQMGVLTKAGPGLRWKFTCTLLRDFLTARFLADLPQNELVRKLEDHHFLRSPRAASIVAFCLGLYRNDHSAQTLDFLFSQMASLNARRSKKVVFKPKAEPDFMDENHLRSGAAMSYCHSLMALTEVEGRSDAIEILANSFPRLLQLRGEGIINPRMVSGLCYMLKDPKVKVLNVEINLVNLHTRQKELYLSIAEALSQTSHLKTLTVAWSSLSLMSEFLKVCLSKRPALQILRVEDFTKKAIKTVEASTWADLQEFCSCLSSVTHFSFYGCHMSSVTCHVINSLPAELQILDLARSSINMIGADALGKFMENSVATRELRLTDTELEGTDLAALFQGLKRCETLTCLGLSGVSLGRTGFVHLIEYLRLASTVRDLDLSRGRLSMEMCSALADVLSEVRGLKRIDFTDTIVPAKGREVLEANATEAIYLDGLDIDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ37</accession>
    <name>A0ABM0ZZ37_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ragulator complex protein LAMTOR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101847955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LAMTOR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937491.1">
        <property type="nucleotide sequence ID" value="XM_013082037.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847955"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13401">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13401:SF2">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012937491.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18101" checksum="15B29C8671573E4A" modified="2025-10-08" version="1">MGCCFSSDEDKDVGIPNASERTPLLDPGQADHIQQIQGARSGSTYSQQNQKGDEQSEFNRILRQTAINVIDVTSTESQNLEQGEMQDRATQYSNRLNMVLSGSGKSRVYRPNLPNGITSPQMTLSAPPVSLSDLQLINDFSEKLASAAREIKIEHKESLVVTFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZE8</accession>
    <name>A0ABM0ZZE8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adhesion G-protein coupled receptor G2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101854016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012937684.1">
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="ADGR_G7"/>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
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        <property type="entry name" value="GPCR_2_secretin-like"/>
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        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
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        <property type="entry name" value="7tm_2"/>
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        <property type="entry name" value="GPCRSECRETIN"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="25"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    <evidence type="ECO:0000256" key="6">
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    <evidence type="ECO:0000313" key="8">
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    <evidence type="ECO:0000313" key="9">
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    <sequence length="389" mass="43103" checksum="D73EDC56307559C4" modified="2025-10-08" version="1">MASLVITIVTYALFKVLRGEKSGKILLNLCVALLLLNTIFLVGTVDVSDFSNTTCVAVALMMHLLVLAALMWMLVEAIEMYQALVTVFTSYERLYLLKRCIIGWGIPVLIVAITAAVDISSYENKKENRDVCYLTSDNKATYYASLVAPACLIIIINTIIFIMVARVILKPRFQQQPASTGSVSVTPAQVRGAFAVMFLMGIPWIFGPLALREARVVFAYLFTICNSLQGFLIFVFRCLFNPEAKLAWIQLFTTGTLKRRRGPIKSMYTDTSSKGADSQGRRLSNSNSGTGYHASGTTRTTISKNGTGSHPHPHQLHTTNGWHPSLNGMRRESDYKDGPPGYSTNDSRSSSRSLSPLDRRSSEDLTTVVKRGSPPDEYGRPYPDEMTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A016</accession>
    <name>A0ABM1A016_APLCA</name>
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        <submittedName>
            <fullName evidence="16">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101854327</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_013082608.2"/>
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        <property type="component" value="Unplaced"/>
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        <property type="match status" value="47"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR001881">
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="EGF_Ca-bd_CS"/>
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        <property type="entry name" value="VWF_A"/>
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        <property type="entry name" value="vWFA_dom_sf"/>
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        <property type="entry name" value="Growth factor receptor domain"/>
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        <property type="entry name" value="ASX_HYDROXYL"/>
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        <property type="match status" value="6"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
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    </dbReference>
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    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
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    </feature>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012939252.2"/>
        </source>
    </evidence>
    <sequence length="259" mass="28785" checksum="7E0745A66636B52B" modified="2025-10-08" version="1">MTVTDFGGFFANACLPFDPKDVLYLTAGWPGTCFSRISGWITASIMLERCLCIAVPLKVKTMITVKRTVIALVSIYVAMIGALLLVFYALRLEPRYSPLKNETKIRIVYITNGFAIESAVILINAFSQLITFSIVIICSIILVQNLISKSKWRKSTSSSGDHDAFSNRDKKVVKLVLFIAIIFTVCLSPSVINFIAQSLEPEYTASGKYGDLFLLILVVWSFSASLSATNSAVNIFVYYNMSSKYKQILDKMFLRGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A322</accession>
    <name>A0ABM1A322_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome transmission fidelity protein 18 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101860109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939837.1">
        <property type="nucleotide sequence ID" value="XM_013084383.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860109"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="387"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="858"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="858"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012939837.1"/>
        </source>
    </evidence>
    <sequence length="964" mass="110553" checksum="BBD7CC5000D3E61E" modified="2025-10-08" version="1">MDDSFELEYADELDAIDDFCPDDDLVSQTQNPPKSKRSLQFESPRAGGKNQDELISKSQNRHAEEVDDVHLDLSPPSPQPLVINSDDHSHGNERTTNRKRQPSEDDWFEEETDVSLFELAQVSSSRKKQRLTADQEVGLDEPDSHTIRLIEQIQQHRMKSHTHVEDSDDAGKGHQIRFNDAEDMERPRVSKRIPKEDFVSTVGYGGERVYMKLWAEDVLEAEYLSLGEESRSSGLLTVPVCVMKEKMEEEKSRRAFQESVDLSASIERQLDDPMVEAELSTTEDISSATVAGDVEESDGMQELTDEMRSLWVEKYAPRKYTELLSEESINRSLLHWLKLWDFVVFGKDVPKPQKTKNFKKDKEKDQKKFKKFQAEVEENLDAHNRPQQMVALLCGPPGLGKTTLAHIVARHAGYNVVEMNASDDRSVDVFRNKLESATQMKSVTGADPRPNCLVIDEIDGAPLPAINTLLNTVKKSENEKTSKKKKDKGLLLRPIICVCNDQYVPALRQLRQMALVLNFPQTEPSRLASRLYEVVRIEQLKADLNALLALCERTDNDIRSCLNTLQFVRQKQKELTLRDVQTMSVGQKDRQKSLFTVWYEVFSMPRPKKNRFVSIQDLAAGKQEALTNNISPPARYQHILELCQSAGESERIMQGLQENYLEAKSKDPHLHGLSLANEWLCFADHLNQYTAHSQDYSVMKFTPFLPIVFHFLYASNAPPRVQFPHKQAELHQSVTKTLNLMTTLISDMTPVVRKFVNPRNMVLDLLPPLLDVLQPTLRPVNAQLYSAREKEELLNVVNIMIAYNMTYQQEKSPEGQYVYSLDPNVEEVVKFSGLKQRKQLTYAAKQMIAREIDLEKMRKSERPAVRSEPEQSVKPAESETRKKTPAVPNHLQKLEAKRIADEKPSVNFFGNFVRTKRKKVEKEEDKEPKQDPKKKSLLDTLIWFHFKEGFSNAVRRNVKVQDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A326</accession>
    <name>A0ABM1A326_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal transducer and activator of transcription</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101861517</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the transcription factor STAT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939841.1">
        <property type="nucleotide sequence ID" value="XM_013084387.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861517"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16855">
        <property type="entry name" value="STAT5_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16849">
        <property type="entry name" value="STAT5_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.20">
        <property type="entry name" value="STAT transcription factor, all-alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.532.10">
        <property type="entry name" value="STAT transcription factor, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046994">
        <property type="entry name" value="STAT5_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035858">
        <property type="entry name" value="STAT5a/5b_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048988">
        <property type="entry name" value="STAT_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036535">
        <property type="entry name" value="STAT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013800">
        <property type="entry name" value="STAT_TF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015988">
        <property type="entry name" value="STAT_TF_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013801">
        <property type="entry name" value="STAT_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013799">
        <property type="entry name" value="STAT_TF_prot_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01017">
        <property type="entry name" value="STAT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02864">
        <property type="entry name" value="STAT_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02865">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21354">
        <property type="entry name" value="STAT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00964">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47655">
        <property type="entry name" value="STAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48092">
        <property type="entry name" value="Transcription factor STAT-4 N-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0010">Activator</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="644"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="161"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012939841.1"/>
        </source>
    </evidence>
    <sequence length="839" mass="95276" checksum="7DA831A3AE52DDD8" modified="2025-10-08" version="1">MENFSDSDSSYVSLSELDSDYCLNKNMAECMMNGISRLPQEGPSQDLPVPTPTMSQWAKVQQSPTIFRQMQQFYQSPFSMEVRYFLCQWIEDQQWDQIDENSAQYSQLAEQILGEMLELLRQKAGELTSQEFFIIQYKLEESVQKMEMVVKSNPLELVQIIKQCLAMEQRLIEQAEQAELQQQHLNQDIVGATQTGVNEKIMAEIQVLQRKTAATENDLKNLKEKQESFIIKFSDTQRISAQQQQVQQMAESADRTQKLLQLKKQKEDLDMQLTLLAQDLLQNRMALSKKYETTITSLGDLQKEILDNELIDWKRRQQLAGNGLVMDASSVETLQQWCESLADLIWQNRQQIKQSTTLQQQLPIKHPDGEDDLLPKLNDTITGLLSSIVTSTFIVEQQPPQVLKKDARFGAVVRLLVGGKLNVHMNPPTVKATIISENQAKDLLRNDLKAKNDTSGDILNNTGNMEYQQNTGQLSVSFKNMQLKKIRRADKKGSEAVTEEKFCILFQSEFSVGGNELVFQVWTLSLPVVVTVHGNQECNATATVLWDNAFAEPGRVPFTVPDHVDWMMLGDQLSMKFMSQTGKGLSDTNLTYIASKLFGAKDPTTCKVTWAQFNKDTLPGRPFTFWEWFYAIQKLTKEHLKDLWIDQAIIGFVSKGHAQEWLSNKPLGTFLLRFSDSEIGGITIAWIGERQGVWNLAPFTTKDFHIRGLADRVKDLNSLVYLFPSKPKDTVFSKYYTSATEQVSNDGYVRPQLRTTIPDEFNTIAESEMHPLSPDTPAYVHNPGSVHSTVTDMDDLPLTPLAEIDLNGITDYIPADIDHINAISDMDVSQLLSNTNYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3N2</accession>
    <name>A0ABM1A3N2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862048</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940173.1">
        <property type="nucleotide sequence ID" value="XM_013084719.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862048"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940173.1"/>
        </source>
    </evidence>
    <sequence length="816" mass="89489" checksum="87F04A7FE45D4F6A" modified="2025-10-08" version="1">MCASLSSLGTVVDDGGGNPWCTAGQFMSAVKGSPINDIELTGVKNHEMELVNPVLRAVQNVRAILKSHKTLDVDEKGQGCDSETWPKSFGADQRRRQRSKLNIARSDVNLYEVCYDGHKGYTSKAFKLLCSGTDTLNDSQTLQPSGAGRGCHMAENDVKRAFPRVYDRMTGQESKQRIGAREQIAVGDRFFKRNFVTGSSSEQRFNRSPAPGWFWEVVALGTSQEVSIKMDKDMGYEKGLSVDNQADVKGGTAYTGRLGTTNGYPSHVKDRAAGRFVRGATRKAPCAGAGYDERLCFQSLERRLRAPKKGVEKPKYSVVRMCSDCNQFTPVSEEVVSELAGKQSEHEKTAQRNDGNCTRALRGGNVVADSVEQTIKANHVAVDNTLDQKNVSFCVTHGERTESQEGHRVTADVSKTPAENVNFSDAGIKKRGSRELTGENYVLGEAPADVIRAPQDSSPPSPYTPAPVALGVCHRDSSAPRVSGGNADTKDREGTDPQSCTEEESCSRKPCGKRWISLGTPVKKKDWNNTEMSAYSHIHVPKTMGGKKSHAAHEKSRSSQCNGEEVKTGGQEPHEMNYHLNPLQLLPNRAPGKRLGSKPLGQAVMYFSCDDKAAQRSVAVHQMPRSKVNTMPRSRRFQGRGSRAIHHTREQAKCEETGRDVGVSQTETNVNVGRTSEEFFTRFPSHHQLSSSSNLQAAIAASRKAQLKSRDRKTPIVSKSSSGRSRPIAGGDAFVKYRDVMSRVRRQAFFAWEERQAAAHPGTVVCEPHVSRDPGKTDQHTGRQTCECDSCTQTARWVSSLGHSCFRPGLHDVPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A411</accession>
    <name>A0ABM1A411_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012319</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940373.1">
        <property type="nucleotide sequence ID" value="XM_013084919.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012319"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940373.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20471" checksum="F2EBFF95525FAF30" modified="2025-10-08" version="1">MVQSSVPGQYGHTAAQVMARRHVRMHLRKIREREYCKLRALIPSVASKKKVSKVQVIEEAVRYIEELHSALLERFRQKHGELAEDKAQETVQYFMNQMVPQSPVTLTTTTSSPSSSPLSSSSSLSSSSSLSSSSLSSSSPLSSPSFRSPLRSLDGPLLMRFSPANFEKQRKQPSFSLRKTRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4U7</accession>
    <name>A0ABM1A4U7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012433</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940866.1">
        <property type="nucleotide sequence ID" value="XM_013085412.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012433"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012940866.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32520" checksum="5DA670FC07BB9855" modified="2025-10-08" version="1">MKDPHRAAQVLASDSLDTYAKKFEEAMSGQGVSRKECLTHDTKKALVQTMRGLSAVTRHLLSSGFQNVLLREIQSDRIEGEFSVYRQSTGANAFMTAGDVISACKKRLVRHATSFLESIDVIADDSPSTSDKHLCCGPLVAADGEAIESSFSDVTLTANEESCCAYVAGWLERKCIDDITFSDDEPFVSTEVKSFLEEVSRGSLKTPHMSTYELTRIGLSFVKKAKNRVYCRQRLVGILSTMGEFPDFDIVQSKKLLRHLASVLLRGLHNLEKYHQKKAALLQTSIKKARMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A516</accession>
    <name>A0ABM1A516_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centriolin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940964.2">
        <property type="nucleotide sequence ID" value="XM_013085510.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847597"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940964.2"/>
        </source>
    </evidence>
    <sequence length="510" mass="57621" checksum="36B67BEE3BF0EDE7" modified="2025-10-08" version="1">MVAGSGAGAGYPVGSQMYFPSGPAQVSHYGPGRMYLPAGAGHRGQHPARIYYPAQHSIPMPAPGGAPPPPPPGGPAQLINMGHRSAPMTPIASGTPVKGGAPPTGYYDGSFMMAPPSPIRGVGMEGPPRGILKNSGPDQSGMDDSYLFCNVPEHHDLEDYISELQEKLKKLKVRLAKEKDFQEDSIQYQEKKAIKGLLRELEDRRDELEGLDLAIERQKRNLQEMKLDERDLRRDKRDARDELVSLRKRNDRRLVSKLKSGADESFDEAMERSRQQYLQSEVTCLEKTLAKRQAQLKEVERSLRDCNVNLKDAKEEARSAVERYDEASTKLHEARREYQEIERRSNEVGIELVKASEQLGSLRSEVKDAERKKSKQEKLLREIVNVISKKDIEFKDVDGKVKSASQSLQRLQTDVSVHSQREKEMVEALRDSEDVLAKRRGEIQRMRDQSAKVKNAITQKIEQNRQELERLDQQLGRKRTELQLLQDSQDRKQQEMSGVLHEAEADIASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5C5</accession>
    <name>A0ABM1A5C5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC106012521</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC106012521</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941132.2">
        <property type="nucleotide sequence ID" value="XM_013085678.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012521"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057448">
        <property type="entry name" value="BCL-11A_Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25491">
        <property type="entry name" value="CCHC_BCL-11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="736"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="385"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012941132.2"/>
        </source>
    </evidence>
    <sequence length="761" mass="81943" checksum="2570D8E085E31D48" modified="2025-10-08" version="1">MSSYQQRYLTGHLYKESPPDYLTCGHCAKEFVLDNITLFIAHKAGGCDDWAQSKGSPSGFSGYDTSSPLTCSSCSRVFMTARGLLQHVQQDHQMSICLQKGPLFIDGDSAPAEGDTGSARPPPAHASINSRDYMTTDKQKSPCPTASSAATACCDHSDQSDQPTDLSMTCSNGLGKAVVKCNDHGCKITLEPKKNVRDAPAPSEVTDANKAATLPKKRRFLTATDNEFTSNSGNPSNPNNANDVMQAIPSNASDVTKNVNIIESGEMTNALEDIAEGDDDSVFYQRTTNVEESKEAESASNVSVYVTAQYAKDELCCVSLSTQKEKNAKLKKLLETEPPADSKALESVVADADSQCADKSTTKLVYKFPFLVPKSPDSVKPLLAVTEGSADGGGSRSVARGSDSSPHLPPAGDSYGQASRGPGLGFVPGSTLEQNIDRIIRASISSDAYPEEFDILRMETDTPGSLKSGSDSSRSPPTGHPSMARSPRLVTPTQQYRRMSQSSVDYDMPMLINAVKSSDIYDSPIYKLKPPPPVTPGDLSNKMSPVPVATFLPPGLSPHPSMDDQVGLHRQKDVPHLDSASPPGGLRRYNNSLARPEPPTFMPVDGANPGHSDRHFLQGHYATGTQGSVERAVGLDKAFRKGFGHPRVGVLDPGLPSLTSVQQQHQALYRDVADSQWLGLQEDNSSNGEFHGAVGRSGMDPLDMMAGSDLSALDLEDKGYEGKAMKKRRYPTSRPFKCDHCDQAFNQRIHLKKHMSKHTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7B9</accession>
    <name>A0ABM1A7B9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942252.1">
        <property type="nucleotide sequence ID" value="XM_013086798.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849638"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="728"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="951"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="854"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1534"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942252.1"/>
        </source>
    </evidence>
    <sequence length="1598" mass="179468" checksum="4D83106274D784BD" modified="2025-10-08" version="1">MDRLGQFSSPLLGSFSLPSLAEGSEAISEAEEINEVKSLHDRGARAAKTSDFDEALQFYNEALEIDSRDVKVLQARALVYLQQGNTQAALQDAEAILAIDQNSSIGYLLQGIAYQHMSMHKQSLSAMLTALDVEGSNPEKVTNHIAGSVSQFCQITPSLAITLKGMDPYEKLSEVGVVLFHHKRYEACIDVLEAARKLQTNQKGITMRVLLTLANAHSQQMHVETAIGLYQECLTLAVATHEQVYQTKSLVNIATLHLENGDTYQAIIFYERLLHLEAELLSQVGGSPGGMPDYWTRELQCGLHLNLSIAYKTIGNMSSALIHARKYMGLTQKFGLDPKLVAESHHNTGMLNEILGNYQEALMEYKQYLAMSKNNSNRKGIGQAYGCLASVYAALRNWSLSLSFHDQYISMATKAKDRRMMAIAHEMMGDTLCVKEDYEQAIEHYNHMLMLCRNRDNRGDATSRCKMAAAYRSLGQLQYSIYYYNEALALAHRFGFRDIETMAEFHMACINKDSTQYVERDEAQKSFMRLIPFFERKIVEHTEENSHCPQEYEEKLQQCYDGMQAVLSVMSNKLGCLQYAEAHRKRCVIALPNFHATCRASNHSLDSSREIWGTEHMRRIVSEQNATVLYYSVLDHFLLMWVLQPAEGVVRFYTARLPPGSSSFPCLITELLAEVREGWSKADLFSTSEPRALPLRDAETQLLRSKNLRLSSAKPATESARSPDVKKPALRRLFDLLVAPVMDILDKLEDQSHLVVVPDKQLKLCPFGALLDYGNRSLGEKFNITYLPCLLLLDRVVQNEVAAVSAEGELDFQRDQCRKGGLPKQISEHSEILNLSPDPVDDIVSESALSREPTVNLREVSNPRLASSRSQEVSSSKVNKTARSRESTFVSLGGRSHRDIPTPVPENKPVVPVKPSTMSLGIPTSLEKMLSVHTYSTLTTRTWTGTDITSSSQVVTQFQQISDPRAALVFGCPNITKPVTVHEKDWMPKAELVRAQQELVIVAECLGSFPVMSEEATRHVLLERLEKAEVVHIATWACLREGILLVTPDPVDDQSEDSSHLVTVADLLNTSMCAKLVVLSSCGLSAARHEQECVYKLASAFLSAGCQCVLVSHWPLPDDLLGKFYFHFYQTLQNGAFLSEALQAAVQAIKADDRWDHVCHWAGFSLIGKDSKVNLNEIRHAHLDQLIDKCEAELEEESDTPILNPKAVVPNVSSKEHNLSVLQKHVRSLLKEHYKNPRVITDLVDLLDAALKRLHTMENNRQPCRLTDVIAGSSPAVALLKWLGFHFQAKEAELTCPYIVFPHWNTDELLIPTYDALKAVIELSASPKCVSALTEALPITQDNISCLIDLMSITKHAPEIQLKVTDLSVHPLWHYTKTRALLQATGFHQVGLLLTFNMMATHKQLLSSMLQLLLSFSCHKSPVLLYRLDVNLLGRASDTKSSLTEQPRLPSLTPLILPRNQLRMSTPWFSVTEHRDEMSEKMKLAKSSSNLSEEFQDYLERARTWHQTTVVAQTDEEAKETLDKYGRPTTIPKRKVKVKSGSTASQPRVPVDEARSLSAREVKQRRDYAHFVLQERETDIANRRKDGLLKLYLPYIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8A7</accession>
    <name>A0ABM1A8A7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein CLN8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101856776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012942747.1">
        <property type="nucleotide sequence ID" value="XM_013087293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856776"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF7">
        <property type="entry name" value="PROTEIN CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012942747.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24579" checksum="FD88053A53DE4AC1" modified="2025-10-08" version="1">MISFCFLLPRLPTTGAWVVFTPTNHDRDPVFGLSATGTFAMTVTAGFFLFECLALTWSDWTTNSLSKMLHLHHWLSLAGSVTVVLTEAGYTVASRSLTLEMSTPFSALCWMLLKAGLGRSWLWTVNQMVLLHAFHLRSVVECHIWWNTFTHRQAIWADMPWSTFLSVYAALSMFTFMATPYWGYKKTLQMGHPHDWNFENDQDDTLKNGKLAKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8Z5</accession>
    <name>A0ABM1A8Z5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA (Guanine-N(7)-)-methyltransferase non-catalytic subunit wuho</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101847685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943107.1">
        <property type="nucleotide sequence ID" value="XM_013087653.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847685"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012943107.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32775" checksum="A3B77967B37165FB" modified="2025-10-08" version="1">MVLDMLLIDHDQCVVTCDRDEKIRVSDFPDSYNIRSYCLGHTAFVISLVCDSRQKVLMSGSGDCTVRLWSLQGKQLLTHNVLTDLPSCDVIQDDPNPEPPSTETTDKPSTDGVTTGHRPAIQQLCFCEPCGLLCVAMYRSPQVLIYQLTYPPPSPDPDTDISQPSLSLLTSLSAEGLVLSMSVSGCVLWLLSQRDSILKLSAHRMDGAAGTVQEVEPSATGEGGVSRLLHVIGGQADFLTVTDLGAPDPIPHLWKSHTDGYIEEYKERKRQRMEGKEESRWGRKHQRRPERQTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A924</accession>
    <name>A0ABM1A924_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TBC1 domain family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101849238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943151.1">
        <property type="nucleotide sequence ID" value="XM_013087697.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849238"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF16">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012943151.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="59359" checksum="A94B78B60DDC8E5A" modified="2025-10-08" version="1">MLLMHMEEISAFHVLKYMMYDLGLRKQFRPNMMALQIKLYQLTRLLHDQYKDLYEHFEMHEISPTLYAAPWFLTLFASQFPLGFVARVFDMMFVQGIDALFKVALMLLGNHRALILQCNSFESTVDFLKTTLPEMVQVQMERIINQAFELDISKELQAYDVEYHVLSEEMSFSPALLPHHHHNHRNSNSHRHHSLPQQHNSPSLQHQAMQHVHHHHHHAHVAKSSLEDRPTRLVDRRRSSIDIEMLSRLEQQNRGLKQQNMDLLEKLQHSQSQQRSYEHSVHAHQIEQDKLRSHVRTLELERAALLSAVAKLRKLVPRAALQNLHLTLPQLPPTTPSPTSSSSSPGFPGSEPESVGPSEEGILSSNVRGDVEAPDGGQKSESRDGNMEKASATFIGDNSAGGLFSSEENTGDLSAKPCSNVEGSSVNTLSGASAEVSSQRGLSSQTTPSGAATTPTIARRPRELSDKNVLSSSSVVSESSLSEQSGPWSTPSMHSSSTGAAQSRNAPRGSGHRDEDNKPAGPRSLPHDAAGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9W4</accession>
    <name>A0ABM1A9W4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC101855751</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101855751</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108570.2">
        <property type="nucleotide sequence ID" value="XM_005108513.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012943624.1">
        <property type="nucleotide sequence ID" value="XM_013088170.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855751"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021281">
        <property type="entry name" value="SNAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15132">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15132:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108570.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012943624.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="43700" checksum="34E1BCE23D85F868" modified="2025-10-08" version="1">MADQCPQNSSRRSKSKCGTEGSTPSGVVKRSARIQKSVTKFSEVKEWTVVEKTKLLEAVRRFSPDNVEVLSSIVGTKTPEEIADYIKTLSKMKPSSRRTYQKTKDDDKEKSPMELWTELVNELVHYEPTDLGRCVTKVFGLITHNEEFAPSEQPRLSWRRIYQFLSDVLEDKAELQELSDVESHVVLDMMHGVGDTLHSSDTRVHQRLLTTKYKFLNTKLTELSEPARRRRYSLVHRGLHNDFDYLEEPSEVSDPTEPPTSCQENDDVTDVSAAAIGNTECSPAGYVTSTSVSTCASAETSSSSAQQSALTSSSPPAPTPGHSGHREESPPLTAESPSLAPGVATGDCRDASSSSSANHSSCGVSTTTKEFVKSKLFTLNPLCIPTSLLPLKPNIDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA94</accession>
    <name>A0ABM1AA94_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101853413</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943844.1">
        <property type="nucleotide sequence ID" value="XM_013088390.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853413"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943844.1"/>
        </source>
    </evidence>
    <sequence length="792" mass="86707" checksum="4F20D8609A9581DA" modified="2025-10-08" version="1">MNNKKDSGASGVADLPLPANWSMKMSKSYPGKMYYVNKVTKESSWRHPLDKTPTNKKKTGSAPHLASHKSTKGTNSMEDASSSCSSTPNLGPSAVSAISHLSEEEQVHVMGFKSKTQQKSAPLMSLATDSNNSTLNDSVIYLRTDPNNSTLNDSVICLHSDPADTKKSEAKAIPEESSSKECSDKRKTRSKKKKKKKKKSKGAPELEKQSDAKAERILGKDSRCDLKHKLAVSPSQEMTSKGLSLSDCNAEKVTSTPSSGACLSNSRPVLKAKRRSKGLEEDSSAKHSQVNRVEPAAVSQKNTEKERQADIVLDPLPTGRDSYHDHSPTSSSSSNFGFRDAPILPSVSDSSVIIVEPNDYSTDQRADSSVIVLDNTHDVIDLCTPMKRRRVSSKSDGTLTLPTRPQLTMISHINLLAKKQDVGCESMSHKVKEVMPVASPEKIANEMKRKKPGLPGECSSEKSSREIAYNESTSELPREKSSAYGAEAVLSSKKSVEQCEISTQQQPSQSSAAFPLPGDVGVNDGLADGTDATETVREIEDMDFEEVGEIVLLNIQNLRRNSSHLTCAPIGTLTEAVAKSPLVSSPVVIKIEESPEKHKALILVVDTNVLISCLTFLSEIMNADLPGLGIPTLVLPWVVMQELDFIKDSRKRRDRYNEMTWRRAVEAVHFIHAKLNTKDQNLIGQPPKEAYQKTDMVISSNDDRILQCCVQWKEKCPDDHVILLSRDLNLTNKSVIMGISAANTETLWNELRMPKPNLKLLQKPPSNETTQKGNQNVAATSGKSKNSEGSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABA8</accession>
    <name>A0ABM1ABA8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101853197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944417.1">
        <property type="nucleotide sequence ID" value="XM_013088963.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012944418.1">
        <property type="nucleotide sequence ID" value="XM_013088964.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853197"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012944417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012944418.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17186" checksum="B39EFCC44E7BD01E" modified="2025-10-08" version="1">METIVEENIDPNDLKKFEGLYNEQARRGHISEKTQFDYAWCLIRSRYVSDMHKGIALLEDLMRIAKDDLSQRDYLFYIAVGFVRIKEYERALKYTEAIRKIEPNNRQAQQLDGYIKAKMKKDGLLGMAIVGGAVLALGGLVGATIAAVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABL0</accession>
    <name>A0ABM1ABL0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013420</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944567.1">
        <property type="nucleotide sequence ID" value="XM_013089113.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013420"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944567.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29103" checksum="04265E4512574B37" modified="2025-10-08" version="1">MPRDPTGLTSAASRESRKSLPVPVLRSEKTALARLSLAEDGRKKSTLLPPLDKEATFLRAPRKGASHTSFSDDFTETKRFKRVSVEMDRKIVTHLKRHLNKRIQKRFDGLGETWEYTSDGEAGPAVGTDGWRSQQKQERERTIFHNYSETGEKILNGGRGRRSSSQSPTKTSVTSNGRSCASLNEEHGENDVDSTASNAKSSQRQEDVNQTFSKPAPLPDIRRNSSQSTGPSTGGDASRRTSIKTVNGGGGGGGEVAKVLVTQMSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABY4</accession>
    <name>A0ABM1ABY4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101849503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944782.1">
        <property type="nucleotide sequence ID" value="XM_013089328.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849503"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059081">
        <property type="entry name" value="PRRT3-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052836">
        <property type="entry name" value="PRRT_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578:SF6">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25987">
        <property type="entry name" value="PRRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="942"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="Proline-rich transmembrane protein 3/4" evidence="9">
        <location>
            <begin position="812"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="562"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1331"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1384"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1478"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="750"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1337"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1496"/>
            <end position="1513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012944782.1"/>
        </source>
    </evidence>
    <sequence length="1531" mass="166175" checksum="5F657B0C32B70B6F" modified="2025-10-08" version="1">MGSSSSPSPFPFSPSPSSSSSPPRVLLLCAAFACLLGPLGLCWGLHLTPQQQGFKHHRHPGQSTLHPPPAIPSRHHTTSAKLLTASRSGDILARPLVHSISAGQIRLLSSLSPRGSDERPAHYPPPRRSDKSKLFVSRESQPFAAATSYAGTEIDQAGNNLRSLSLPSSVFKYRRGKNVDKTLLSGSNKLYGNTKPFTELSLGDVGYLLDESSRDKLTRSDASRSNNDQDMRVVSLNSMTPGGQGRRISSGSVISNRRAERGTTPSPLSNSEISKGGNHRVSATTTTTTVYSGGRRWRYPGRGGPSSHKGINSWEVKRSRGGAAATRHTEIIISSSSGKLIRRRRNAGDNSSSAAGDGFGFFNDSFDHNNDTSTAWSSDNVTSEADNNEIPVAEPSTAVNLNTPVFSEINAIPEGIFDSNADDNSSLKIENPNNPSIHSNTSTVDDESLSSGVNNNDFNITIPESEGESEPKISTNETNTIPPVTTASPSIPYSNLNQDVVKDSNTTQITGGSSNKEKDATTSADNLKDGMNDDQLTGTITTGSPLTTAKVGGVHWIPDLSQVTSAEPLEPEPETTESSATKEPVPETEPPVSEEPTPETEPPDTSTSPETGAESESGPNDDNSNLWSIKSEKITPNDPSDPDLRLLTTAQTPPYTKLDDGSETNPNTPVVIGGDKVPPFDPDSGKVIADPNSSGTDPNPEGFDTSTNSHPLPRANGSEPEVEPEPENEPTPESEVGLAPKTEPESESAGEPKPEGEKEPEPEGEGKSEPEGEGKSEPEGEGEGEGESEAEGNSTSEYENRHRKRGGGTYEPAVEPGPEWEEAKEAWQFAWEIHIYAFGGLFGLLGLYTCLSVVRLWRIQRLLSRPYFLSLNSLVLLLCGTRSFYLLYDPYNSEGTYHVSLNYFLYSISFPCLTAAFSILLYALLRATNMRLVSPAVQKLEILVLIIIVHFVLSIATDVLLGFFAGIQVMLFVCQVYFILWGLFLFFGYAYIFRKLYLHAVKRQKNVMYGTGNNANNSTKTKTKSKFTLSAAIKVTFFTAICGLVTVGLEIYAIVGVYNTFTGDTPKPWPWWLYHTVLRLIEFLMAATMSYVASQPFRYRKREGSCGCSAFCAPCTEILCCGHTINRPSTSSTGWTDVDGTSASKFHSLRLDSRGSFNNGSTRKLFARSDLASDSVPIVEQPTPNLGSRPSSLLIIEDGYVRFQTENDINRLVDSSYNNVADAEKNSTSPQNVHNMNTFRVRDGFVNTGYIAHNTLEDKKKRGGGGEGGGKRVGVIKEENADATAVVDVTDGVEKDKSRKSSMTSAEFFRIPSSVSLADSMENELEKAFESFKVDSSGEEEKEEDPDTRSLDLGLVATSLPHLRETDLISVDSLEDTTNFRGASEKSVLHNAGQLENGDPDGGLSNRLSPERRPITLLRRAKSSELAKPPGDQEAEEEAAPYPAQQKLCRSYSDHSSGCQRKNSTHVKYSYLQDMESKENRVLNSEGNDLDIERTSPISNRRPSDSQGQQAAIMTSLLKSKDAGSSDNIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC01</accession>
    <name>A0ABM1AC01_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="5">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101860933</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="5"/>
    <dbReference type="RefSeq" id="XP_012944811.1">
        <property type="nucleotide sequence ID" value="XM_013089357.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860933"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="113"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012944811.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33965" checksum="D3BDB830520378E6" modified="2025-10-08" version="1">MNLGWKPKYGRFDVLPLVISVAGADPVVFDIPPDLVMEPIAEKLGLDTMSNSSLWKDRALVEINVAVLHSFQTAAWLTHVWEKDRGMEKKKQIPFKILSHHLWSKTLAQRVMCTILFASETGRSESFADNLYDMCKPYFNAKVVCMKDYMVSDLCNESLLLVVTSTFGNGDPPVNGQTFDKGLKEMIKNSATLIENGYSVFALGSKAYPHFAEFGKTVDKSLSDLGATRVHKVGEGDELHGQEHSFDTWAGAVVEAACKSYNIVPDKESKNKKETSRKAVQAWTPDTYRLLPQPQTPNPDLCTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACY3</accession>
    <name>A0ABM1ACY3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein DDB_G0283357</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945313.1">
        <property type="nucleotide sequence ID" value="XM_013089859.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848627"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945313.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="65113" checksum="28DA62F6BE7350C0" modified="2025-10-08" version="1">MYFMISKCVVCVDISFANILLNCMFSPSRFPLPVEPHMPHDPMAGGYNPELGMPPNQFPPEPPHDGYDGGASTDEPPSSGRRSNDTLEQPVILGIVLGALLLALAVLMAMCWWKQQQQKRRNLASNPQKFQDQSQCIYADASGHSKPNGGLYPPINGGPHMANGHGPPQDSGGHPRHGCMNIDVNPLAEYDMQTSVHGDRRPPQFYGNGLSGNSKRYGGNHSHENLTSCSGGGGGGGGKSHLQCNGGGDMAYMEQGSGGGVYPMQHRTLPLAPSQPLTTFYADSGSNSLGRPSLNHEYSEPGEREMMTATSSGIPRSSPGLPPHHHHLHQSSSSAASYNGKLSSGGGSERGGGGGGLNNMMVGHRPHHAAEYDYDWSAGNSYDQPRGGGLGAGGVGGETTGALGVSSSLSQDRLPPTYHTASDFGGGSNNNINNNNNNNNNSGHMLYPPPPPPHLSSLSQQQQQLQQPSQRLTTSVSSSGSSRGHPVSAPSYPARPGLPHGGEVESRGGGGGGGGDRGGKQRRRRKRPPSRDIPPREYVMKDQATNTDLSSNEGTFEFTSYCKSGSSSNSGSEVGANGCDSNFGNNGSLESIEDSAQSASSAESDEFEPLRVTHRSVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADU4</accession>
    <name>A0ABM1ADU4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfotransferase 1A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945789.1">
        <property type="nucleotide sequence ID" value="XM_013090335.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858824"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="98"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012945789.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41212" checksum="289D3059A693C2FF" modified="2025-10-08" version="1">MNENWSYLGEFSAWTSYFSPYKLWALYIDDIIIFAVFFFFSSVNGNNDNDSKKFPEIKGIDPKLLKVIDGVTYFAFSAADRISLRSILDNVRNFQVRDDDVFVAGFPRSGNHWAFEVVNMILRGKLEFAEVSFHTRILELMDSCPNERLKEVESPRQITSHSKLSVLPKQIVEKKAKVIFLIRNPKDAMLSMFRLYSVFKNERFRYTGTWEEFLELQFQERFMHGGWFDQVLDVERFMKNHPDVPVYVHSFEKMKENPVEATRALCKFLGRPEDLVEDIANVTQFRNMKEKLDAGKLGKVKDQVFQQGSEGILQKGATGGWKNAFTVAQSEAFDRVFQEKMAGSELAKLVLPYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEB8</accession>
    <name>A0ABM1AEB8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854997</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946052.1">
        <property type="nucleotide sequence ID" value="XM_013090598.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854997"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046724937" evidence="1">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946052.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="17542" checksum="435AEE67DBADC5E2" modified="2025-10-08" version="1">MSPATLLLFLGLSLCHVTCVFGQTFNFAADPFTFEPSCGLENLNGNWSAQGTLTITAAELAGANPQISIQTTSELCTVDISNCNVTSPSTIDACYCTGRTGDVYTLFVRRRARSSQSGASLTAVVIPSDPFLANLAKTDIGTLPLIYNTLSASLQVDEDPPIDLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEE3</accession>
    <name>A0ABM1AEE3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch-like protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946091.1">
        <property type="nucleotide sequence ID" value="XM_013090637.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858000"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18450">
        <property type="entry name" value="BACK_KLHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012946091.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="69385" checksum="E3570C6F5464FD1D" modified="2025-10-08" version="1">MSAVDARPDESVSDESAMSASLKSDFSSQACNVLAELREQGELCDAVIRVESALFPIHRNIMSACSSYFRALFTSQMLTTNQHEISLTQVGADVMSVLIEYAYTRTAKITAMNVEQVLPAADQFHILGVVKACCEFLTKELTPENCIGIRKFAQSYFCSGLEQKAHSYTLDNFHAVFTTSNEFLQLDIDEVVELLQSDNLNVRTEELVFDALCRWIDYSPERRRRHIARLLRTIRLGLLTTNFFVEKVKPHEYVKESEQCRPIVIETLRFLYELDMDDRREVDMSNPIARPRVPHEVMFVIGGWSGGAPTNMVETYDTRADRWVVCSVADTGPRAYHGMITVDGTIFIIGGFDGVEYFNSCRTFDPVKKLWEEAPPMNCKRCYVSVALLAGYIYAMGGFDGHVRQNSVERFTKETNQWSLIRPMHHQRSDACATTLNGKVYICGGFNGQECLNTAEYYSPDTGQWTLITNMNNRRSGVGVIAYNECIYALGGFNGVTRMNTGERFCPRTRQWTDIPEMYSPRSNFATEIIDDMLFTIGGFNGVTTIFNVECYDSQADEWYDATDMSLYRSALSACVVKGLPNVQDYIYQNRTVRNQDHSSTVDPPEHSGPASPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF35</accession>
    <name>A0ABM1AF35_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleolar MIF4G domain-containing protein 1 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946458.1">
        <property type="nucleotide sequence ID" value="XM_013091004.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854388"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="2">
        <location>
            <begin position="109"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946458.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26274" checksum="616D20BEE6A7198F" modified="2025-10-08" version="1">MEEEEEEELGDDDDEEAEMEEEEEEELGDDDDDDMAEEHEGDVEDVESKSLKRKRGENEEDDSELKEDIYGRLRDKQGNIVKPGHIGTDVPPAKRAMMAGSQGNEQLRKKLKGLLNKVSEGAMQAISSQVEALYLDNSRADVNETMTSLIMEAIVTPVITPERLVAETAMFIAILHSNVGTEIGAYFIQTVVKKFDELLQEVDYGAGKLLDNVLLIIASIYNFKQLDSVCAKMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF67</accession>
    <name>A0ABM1AF67_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846482</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946503.1">
        <property type="nucleotide sequence ID" value="XM_013091049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846482"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1840"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1913"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2084"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1435"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1531"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1554"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1688"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1744"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1789"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1850"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1913"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1924"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1940"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1970"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2000"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2089"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2120"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2161"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2251"/>
            <end position="2261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2268"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2305"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="2327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946503.1"/>
        </source>
    </evidence>
    <sequence length="2327" mass="248852" checksum="E381317AAC819D72" modified="2025-10-08" version="1">MEAAMQQQASHEARLLLEGRSSSSSLERKSLEGLRGPHELMASKDPQRVLLDPHHPTHPHPHGPPLHPHHHESRIDTRGFHDPRAGPPPIQQQEKSSRSSSSSSSSAAMMADGRLPRDVMPMMDSRAMHAGPSISSSVVVSSPQSMTSSSRMSRGGPPSQQQQQQQHQQQQHPHGGLNPHHPPDGRINALAMTDPLRVMYDGLQSAYAAVVPGGGPPSGPVLSPHGLPPKSLGTTPNRVMTPMGLSPNSGYPGLNPASGQKPGSLTSSRGGPPPPHPPPPDGPLTPGGGGGGAGGIPSLHGLHDPAHVAYLAGKSSNNTPVGFPPGDPHKLMAAASAGGHYLPADVVKAAGGPSLHDLKQLNSGPSGGHPHQAMSAQHRGEFLRDQSSASSSDMSRGEGGGGGGSSSHYGLSSSSAGMRNMQNLAGKPVGGLDRLDLPPGVHLSRSHMDGHHHHHHPNQHPHQHHMDVRRMAEEQVRKSGGGERVGGERVGGGYHNVSSYESPHAGGLSMSKSSSYPPGAQDMYHHRPPAQVLSGSSSSLTSSSSSSMAPHHLSGVHHGSHHPHHPHHPQPHGYPVDRGGQHEHHVTSGQKGVTVIRPVGHMTDEKGAWREGGGGGGVGAGAGHTGGYHQNMSKTGLRPSGYEEHSSRSSSSSSKSGGGLLPSSSSSSHVHELDTGHHRSLPLAGPPRMQGSISTGQPRIVSESSSGKHSTYPDRHNPGSLSRYQTSSQREQGPNPDPVRQQPPHAVQEERPLHRQTEKSPSRSGGHTPLDLTKIPHGPLDLTVKTKKRPAESPTERGTPEYERMLSAAKRQKLDTNSSNSNSSNSSSRSSVGLGAGKGGMLGGQDNAHNPIWISSPSPRAPETHELRSLASPAYSGHTSPASSLLRGGPQQQQKQQQQQLPFGVSDGGRVSTDSSRGVTSDGRVSVETRVSGDGRASVESRLSTGRGTPVSPHLHPRHAAGAGGMVVGPHPSQHVAKASAAPTSSVIPEMVKNAAGGAGNNPQMVPLTTQLQKVREEQAYQMRMQRMAGGESAVTPHGESKRVYKDTVNPALMEVNPANGAEVVVVRHLQQHYDIPSQQQQQQHAALQHQQMKQQQQQQQQHHHSESAHMSQIHAAQHMHAKMVADQQEIIELAMKDSSDPLQASRTHAASHPGRGFPTPTLLQPQQQQQQLYLQQQQQQQQQQQQQQSQRPYVSKEQASHPLTQYPHHQHMQYSKDPILQHQMAYTKQQAGGGHLGSQSHYPSSGAPYPASKRKEELERFYQKQQHQQQQHRKKVEHDMYKQNVPSMSVMTSPTQKWGTSSSAQQQRGSLKPSPHFPSSSSHQASYSSSSGVYKYGVGGPSGYNPKAPAQTLPNAAGAGVVDPSSSFNKYSGHHLKPERRSSDVIKSTLPQIAGPLPAGGVREESRRALSRRVSCSAGSSGYGASDVMMSSKHPPEGSSRKDSSSSMPDRPLKIDTTEPLSSHVSKSMTSSLNEKPSPGSSNDVIIIKTEEAKVLEPISSIATTSSSSNQGHAPSLSLIGGQSKKGEESNSSLLKESQSMQPPSTQFATPLSVTIPQSPSPITSSTPPPPSRPAVPHKAWSRKQMILNAVNQDETLKRIISNTGSKHESGGISSECKNRILASSTGSPVPTSPKMPILSPQDDENEAGVEERGVQGAQANDDDPPTLDPIKGRQSKPSGVGRSFPMGGSSQSQSSSSSSSSSASMGGVASSSSVPAHQQQGGGGFPAGPTSDSPMVKEAYKNNNNNSHEVVNNNSNGNSSNGNSSGSSSNNSNNSSSSSSVVVATTGSGGSGAGMFSGSTGGSAGAGVPNPVEAAATTAGAKKSEDVPDNSIVVRRCSIGTAALPDHQQQQQQQQQQQQQDEGPKTPQSSVSFHRAEVIRRNSLTGHTLGWGHMKNIPIANVAPFVHSRVDNEKSKQKVEDQIQQSQSQVTTSPSAQGQALGTQNSDIHQPPKDSKIKSSLQSEEEDLKEKAEGIEVKVEGGLKKKEEEASSSSKKVLSPKKKKLAKLRVSSPTKMKELDLIPPSIEYRVLKSAELDDLKALEKLNQHPIVKKTIENRMKYKQKLSKEKSVTKSKRVVKKRIKYVFDDDEDEDDEEDDDDDEDNTMDEDEEDSDMYDVDGKSGKEAGRCDAEAKARDREERALRREQLRDQSEESSRQSPSTTATTGTTPGNNSSSNKDSASKVREKNSSTNKHRTRSKDAHAQGGDKQLKQTSKHGGNKAASRISRRRLSSTNQRAQELKHNALQRRNTGKRKIRRYNRNAAYEQECHREESRRAVVRAKRQASSRARERLQQQQKHLAQDNDNDDATADETWELPETPSRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF85</accession>
    <name>A0ABM1AF85_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106014052</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106014052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946525.1">
        <property type="nucleotide sequence ID" value="XM_013091071.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014052"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946525.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="44474" checksum="69B33BCFAA04A74D" modified="2025-10-08" version="1">MAAPSTEMKALQVAVEHNATVLETILRTVQELHTESLKSNRRMSCLEMTVKSLVDRASPSPGSPTAAQTPGTSELSAKEEILTEILHTSHDLKSKLDKGFGDLLFQQRTHHRDVTASLQNTKALVTSQPGKTTHDVSAEIDNLSKKINQNSAKIQDFSSTIARLINITTFSNTKTKQELDRLCKSVNDTQARLKELRDTSRKQVDSLGSIRQDFDTKGRVLKLLRADSRWVIDQLIAEGQLIREVVLKKRHALKTYSCDFFITNFKTWVGMGQHLFSRLWYIDQAQTYVKGCVMFSDDKTMSVYLVHGRYPRTVGVAGRTGSDVRVSVAAVREIGTGDNWELGSGVMSTDETKIGTQNDGWISVSGCLVNKSLACDELFKRGFVTWDKVLLRYTITVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFC2</accession>
    <name>A0ABM1AFC2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein kinase Aurora-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946577.2">
        <property type="nucleotide sequence ID" value="XM_013091123.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847703"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946577.2"/>
        </source>
    </evidence>
    <sequence length="361" mass="40820" checksum="80474AB1262315D5" modified="2025-10-08" version="1">MPVLKEAKYRVLNKDALEILDMEQMELLADRGNSEVIVAARVRQPKVKRVLKKFLLFEDDDDTSRMWKRSSFEHELSFLQSLEHHNIVRVLAAFQCPSYLGFAMGYHPTDLSHGLLDVTYFEAESYTSQLTNVMCYLHRQRIIHGDLKLGNVLLDRAGRVKLCDFGHSQVILEDTDKPDGWGGTNGYQPPELYDSQVHNAFKMDNYSLGILLWALFFGTAPRDNIDYLKEVDNGSFLKPQHKHCLQRLLALSPTHRAYIWEIARILKDQDTSERYVSKGSVCSLSSESSSDSAQANQSSPDNGSSVTERPESAAVWNQFLAPPPPHPQATSCYLLPQTAYPDSGDVPTNLAPTWPPLHQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFG3</accession>
    <name>A0ABM1AFG3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic solute transporter subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101852378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946629.2">
        <property type="nucleotide sequence ID" value="XM_013091175.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852378"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012946629.2"/>
        </source>
    </evidence>
    <sequence length="300" mass="32786" checksum="7E040248E471D249" modified="2025-10-08" version="1">MLAVVIPRAVLLSDLVSSVYIAFSLHNFTLLVVDFAGGEKRAVEQLAGENLRLRTPPCCCCCFCLPRVAITRVSLRNARFLVLQGAVIRPILAFLSVILWLDQKYVAGKVGYDKLVSCSQLPIPPFQMQADNAYPYLAFPIMVSTLLSVYGLFLTVLSTQGIMASQKIRPKMASLQLTLVSTNIQGIIFTLLNSNDIPPCRGILSTEVRGEVWKHMLIVLEMFLLSMMARCFYRRPHSMDGHGDVESNPSAPTSDIKSISALVVTNGHVPAAPILNGKGVKSVDNLAFSGEEMKVVTASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFR4</accession>
    <name>A0ABM1AFR4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101858915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946772.2">
        <property type="nucleotide sequence ID" value="XM_013091318.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858915"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012946772.2"/>
        </source>
    </evidence>
    <sequence length="131" mass="14833" checksum="472990EA29137D74" modified="2025-10-08" version="1">MMSLSLSNASAREWFSKTRESVRPWAEFVHTKRFGVPKSIVPVPKRIVKNIDTFQGNYLFVFMGLVVFCILTSPFLLVALAACFGACFLISVKNQDKKITVMGCYLKNKSRCYQVVPTLHQLTPEGKCEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPB2</accession>
    <name>A0ABM1VPB2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101861940</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101861940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824254.1">
        <property type="nucleotide sequence ID" value="XM_035968361.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861940"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035824254.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="57444" checksum="FD0588933840C893" modified="2025-10-08" version="1">MAKSAAPTLADLNAKQKQLENIIKSMNTQIMQAQLFLEERIRSDGASGIKAVRLYHEGTSAFFEDNHIGNGALSMHDHANYDRTVGLGEFIAVMNGVEFRTRHNDYKLRMPLKRGKYLDTEYIPFPPVPPSVLKQGSVPKQVAEMQEYFRAFRDQNVTHRDYRNYFKANLCVAEGSWTLNTNTLSEPFQSDRHHIDATSWQDLQDKVRFTSYTGTKSRLENFSWLPTKFYGQENGVPKVAQWTYRIICNPIRYVIKAKHPDLVLPATRRPGSPAEPLADRRSDQEIKSRQVQAQRVRHGEYRFLHRLFHRVSYAIPLEIVYMTPLLSWNPYHVAYTDITPSPQAAAVTANGRYGGFDKRTAFNGTNKSVFYRVSGVPSVYIQFYYSTESEGPRVKNRVKLIPNLAVHHVSFLSPVFSRTPEEFYATGKVEADKADTARGSVGVLDKQGNVHRVAGSGVRVITPSIGGNVGQVRTRYPIFPVHAEGSSTGIELSVRIFCLKTEHVQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQD7</accession>
    <name>A0ABM1VQD7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101858170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035824629.1">
        <property type="nucleotide sequence ID" value="XM_035968736.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858170"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="300"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035824629.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="62234" checksum="A0E32756D9DF2845" modified="2025-10-08" version="1">MTLKTKRINAIIATISAILLISALRNMDVSSSRSSAVNAWTTTPDEAGDDQRLSAAGYGHPRKKITKDMLLRLISSRINTTKQEKQMKDQNLGTAAIRRGESSNTSGVETKTAGDNPTSDNYLQVAKAEIKTEKESVVDKQEHHHQQQEKQEQQQQKRTQKQRQRDLQEQNRNMKKARELQTTILPLHKQPNGKKKNTKTESTLKNVSLPDSTASTGDSGEDDEQGEVIPNLPEVHDVSTPVTDANADKEENSDQNKHSGKDLEPGGSKNDSSANRKESTEGEQENDLKEKTASTHKRPRVLIFVLTGPNSQHTQAQYVKDTWARRCDKVLFFSAQTHKDFPVVDLKIPEGRDNLAAKTLKAFTYVYENHYQEADWFMKVDDDTYLFYENLLDFLSDKDPDEPIFYGHLFKSVKPVQGYYYGGGGYVLSREALKRLMVQGLYPDRCESGGAGEDIKVAKCLERVGVKTANSTDSQGRHRFNCFRIDQHMTGLYPKWYYRKDYNATQKGVKSLSDTPISFHHVEGPEMLTIDFLMYYVRRLKTDHWTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSF5</accession>
    <name>A0ABM1VSF5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Cathepsin L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC101845846</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825345.1">
        <property type="nucleotide sequence ID" value="XM_035969452.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825346.1">
        <property type="nucleotide sequence ID" value="XM_035969453.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825347.1">
        <property type="nucleotide sequence ID" value="XM_035969454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845846"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045023425" evidence="7">
        <location>
            <begin position="17"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="152"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035825345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035825346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035825347.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41843" checksum="5E1DD6F0BEC0CCF0" modified="2025-10-08" version="1">MLLPTVFLVCLSYAVAGPAYMKYFKIESAIPAYPETKVDKDPLMMPAGTTKTYKLSYDDYEETWKAFKDTHGKVYETPEEEKKRFSIFMETVNLIEWHNWRYHNKRSSFWMDINHFSDLTNEEYRVLNGFNKTRSRPFNRDCSEYHPKTKDVPSAMDWREKGYVTPIKNQKQCGSCWSFSTTGSVEGQWFKKTGKLVTLSEQQLVDCSGNYGDQGCNGGLMDYAFEYIIDAGGLESEESYPYEAEDDTCRFEKSRVVATISACSDVVPQENEKALKVALGNIGPISIAIDASSPMFQSYSGGVYDNPECSETQLDHGVLAVGYGNMDGQDYWIVKNSWGPTWGDKGFIYMSRNKNNQCGVASQASFPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVF0</accession>
    <name>A0ABM1VVF0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrinogen C domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826392.1">
        <property type="nucleotide sequence ID" value="XM_035970499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858190"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="315"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826392.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="62062" checksum="34B44FF7C2A9B9C5" modified="2025-10-08" version="1">MGNFFFSVFLVDFRARYLKIFVNRLTSSTRDMDATWTFTNLILVAALVMCSKAWRLNVTSEEIEIGKTAQVSLNCFNPYQQPDISEILLMRIQKKQLSGWFSVAELRDDDVDVRLTAKDVTATGSIVSGANSYMRLSWPLATNDTIGLYRCDVTILNSHGSVGWQKSLPISITHKSDVTVQILSEMVEENKRQCMQQKQDIQEYVAAAIEENKKNGLKEKQDVLQNMTATLKALEASFDSKLDSKIQALSHTVELYKRECPHQLLSHKRQILENVAAALDRNRKEGLQQSQDLLVNVTSIMEDLEASFESKLSVVKSQLMPQSCAGAKGLGIQPVLHLSSNQLVVCDTVMDKDGWIVIQLCLQRRASADVDFFRGWADYKNGFGDLSGNFWLGLEKIHQLTSQVSCLHFDTMDCPNTLSSRSHHQGRYELRFDLRFQGKNYYASYNKFSLSGEKENYRIQISGFSGNVKDRDMAYHNGEQFSTKDRDNDSWGDNCAKTYHGAWWYKSCHHVNLNGLWGSTGGAKGLRWLSVTAGTVSFSEMKIRPFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVM7</accession>
    <name>A0ABM1VVM7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat and sterile alpha motif domain-containing protein 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826469.1">
        <property type="nucleotide sequence ID" value="XM_035970576.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854647"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01274">
        <property type="entry name" value="PTB_Anks"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF1">
        <property type="entry name" value="IP14385P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="1176"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="1340"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="641"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="741"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="810"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1235"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1485"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826469.1"/>
        </source>
    </evidence>
    <sequence length="1508" mass="162419" checksum="97ABF75B0D20C6CB" modified="2025-10-08" version="1">MGKDQDLLEACRTGNVAAIEKLLAGRLGSKGRGSKAAGGGALSSISKSLWSLKSANVNCVDASGDTPLHLAALNGHKEIVTMLLECDASPTVLDSQDCSPLHLAAWSGHTDICSHLLHSPDGQALVNLQTRDGNTALHFAAQHGHDNTLSLLLQKKADPTIRNLEDLSPLDLAAQYDRLDIVKQLITSHPELVAQRSVQQTPLHLASRNGHRQVVQYLLDSGFPLDAKTDKGTALHEATNFCKLDVIRLLLDRGIDITVKSQTGCTAEDILRSIPSKAAEEALNILKTHIYHQRTPDSDGERGIVGEDSSTSRLHQELPPRPVTITGTPLSEGTAANTTTAAATEIPVITTDTQLQKPSIPPSAERKAHLHKRRTKILTWVLPTTDEDFGPPPIPPRHSVRDTDSLGSYNGITPLKVPADRSSEPSSDEDRGKLSTSPRDASPSTRSPSDQPKKPPRKKPLSFRRQDQQGPYITPAAATTGAAPTSCDTAAPATASSGINSSAPSGGSVMPGGSKFYVNLNPEEERAALEAKIAAEALAQSQVQGQLQGQVTEPVVLSVVNVAEPAQGPRLSCELRDTPPQPAVDVVRGSDLADQGSINTEEVKAPEKYVCDRESLKDLPVEPAITKPPNSLDFDSSVIDAQVQQHQQQQQQQLPVSPTHHRQPPTPDCPPPSPGTALQNIQRKIQPMLRFHFDEEEQDEEKRLSRDMETITDSTLIGPEQLPAAPGPVPVDDPTQVVTLTPVTEETPPGPIAGGRPMRPDRPKVKPKPLPRRSSLSSETRDLPAADVAPSVGSSEVASEVFKVQAPVATSVSPGPRGAGSGSGGVGAGTASREGYHGATPANNALQGKVLRKQGQVGSEDNNDDVSRGRRASEKGVVVLTEDEGASATTRDRIVSSSSSSSSSSSNSSRPTSHCGSCSGGGDGGSGAGGDVDQRVEGSNMVEVMGEQVQMRRSVSAGNEPLDWEGHVFADYEPYLLRGSVVGGARSVVHQLAGDNASAAGLRKKRKSTASSAFVTFAPVMEEDKDLDPDKVLAEIDKIGNLPAEERDRKISDDVFSEEWAKISATFETFGVGLSRESVFVVEHEANFAKFLSAGKTGETKIQSVGEWLTDIGLPQYENTLVANGFDDTDFLGGTILEDQDLSAIGVESAAHRKTILEAASRLSALQPLDPDNLPDSVADWLGGLRLDFYYDTFMTHKYDTIERVVRLWELELVTVLDITSIGHRKRILASLGDKRPETTSPARTRIPSSDGFPESRSPFDHVDLFKDYTGVRSRVADPGQEVMGQGPLLDFENSKDGEHLKGQGIRDSSIHIRAPHLMHYTGPIKQWRHKPEILIKGCCNYTAHYLGSTLVKDLKDVISTQEGITKLKHRLRRKLQKSSEVISKIPTIMLSISFKGVKFIDAASKKVVCDHEIANIFCACQDSEHMNFFAYITKDRQAGKHYCHVFSVRSKELAGEIILTLGEAFEIAYQMALKDRAEQEAEEFEKLSVSDGDDSTSVSSKASVNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX23</accession>
    <name>A0ABM1VX23_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10" type="primary">LOC101857810</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103457.1">
        <property type="nucleotide sequence ID" value="XM_005103400.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826964.1">
        <property type="nucleotide sequence ID" value="XM_035971071.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826965.1">
        <property type="nucleotide sequence ID" value="XM_035971072.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826966.1">
        <property type="nucleotide sequence ID" value="XM_035971073.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826967.1">
        <property type="nucleotide sequence ID" value="XM_035971074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857810"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="482"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="515"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="548"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="581"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="614"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="647"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="680"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="713"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="746"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="779"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="812"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="845"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="879"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="945"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1140"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005103457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035826966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035826967.1"/>
        </source>
    </evidence>
    <sequence length="1178" mass="126918" checksum="5A561F47FE1148E6" modified="2025-10-08" version="1">MGNDMQKAAEKAARDAAEMAGKLGFDGDIAEALKKGGLGQGQDLMSDLMQQMERLASQSGGGGSAQRGKRQKPSDKSKEFLKKLVGKDKTVKDEELWQKLRERTHASMDEEDPSCGATPLMICATLGRLSLVTRLLESGVNIDGQNGRGHTALMMACAAGQEDVAQLLMEHGADVNIQDYQGNSVIVTAIAAGKENLVRDLLDRNADIEKRNNKGDNAILTAAHEGMTDVMRLLIRIRADVNSTNVRNWTPIMMCGQYGNPETIQLLVDNGADVNLTQISGGTALEICAGHGHLENVKILKKAGADVNHVNKIGITPLIMAAAHGEALTVRKLIKYGAHVNAADKNGRTALFVSALDGYRNIVEALVKAGADPNIADTDGDTPLMCAALKGHTGIVEILLENGADALMFDFECINALNMAVQNKHKHIVRALLNHQQKPYPSINFKSRKGITVLHKAAMGGQREISSLLIEHGANVNLCCKDGRSPLGIAAFEGHLFDVLLFLKAGADVNTADTDGDTPLMLASAKGHLEIVQALLRMNADISLSDLKGRTALMDAAYSGNKDIVELLLREKAKVNCVEEKGWNALMLAAQFGYTSIVSILFEHGVDKHTRTKTGSTALNIAAANGRYDCVALLLDEGFAVNVRDEDGDTPLYEAAKKGHVCIVELLISRGANVNLRNCNNHTALAISANNGQTEVVDHLLQHGAKIDVVGCEGECPIHTAALNGHRLIVEALVENGARVDLVDAKQRTVLMMAAHKGDAELVKFLVDNKASVNQPESQGWTPLMFSTQFGYCSCMEVLLQNGANIEAHDHKGNTALSTCSANGHQKAVRLLLEYKADVNTVNSMGFSPLMLSCNNGHVEIVHYLLHHNADTELMEHERGNTALLIAARKGKGDVVRALLKAEAKVNSQNRAKTTALNVSAQYGFKGIVDDLIGKRADTELADSYGDTPLLSAAPNNDHLVLTSLLNAGADISKRNDSGQTALLLSAKNGCRQNVKLLLERGSHSDKDIQEALKASQLNPNPEILEMLNKALGKEGEVHDMLPSVATPQQPVFATSVLYWARPWPCPRKSIYDRISRASSSAHSHPCSNNQHRDMLAGPMDLQSSLALPRSAQTPKPDKSVNICVVKNAMYVAGGKQSSIVIKEQKTNDVSDLYPGSDSDRDPDDDDDFECGDSDHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZD6</accession>
    <name>A0ABM1VZD6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855047 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827779.1">
        <property type="nucleotide sequence ID" value="XM_035971886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855047"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827779.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48601" checksum="641C098EFB5E9056" modified="2025-10-08" version="1">MCVQWVNLFSTNFIGRASSQELRTVEEVNNYCLDPYDISHAEEWQEELQNLLKRKQQLKSELLAITQEQKLVCECFENPVQWMETHQSVDKDLAKSDEVLSEVNSLLKESAVKIDRTVDSAFEALSVLRDTLRTSEQKVAALESELSDHLSGQTDSELQLSSLHKLQRGEKSASEKLCLLLEAAKAEQEVLKNRLHRLQSNLACLQQISGPQHQLESDSQRELARLTDLKTDIEQLSEVQCIVRDGRTIDVIFSPQAKRCRKMPSEMEGQVSGSVQLVATLCFKQLADDSLHLGDVKLNENVLGSEEIIERAKSSLDIPTLIMEMKSLWVSSVTLFSEISNIRERHAVDWIQEESVLRLMVKKGRSVVCTLHIPDTYPYSGSVSLENVVGDTSDIAMDQIQAPKDNTLTGWILYLEDIFSRQTVMDSGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZR1</accession>
    <name>A0ABM1VZR1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-beta-hydroxybutyrate dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106012904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827904.1">
        <property type="nucleotide sequence ID" value="XM_035972011.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012904"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827904.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40160" checksum="855E04F9414B4BD0" modified="2025-10-08" version="1">MSDLDLAGFQKLETAGWIVALTFLFFFLGHVFVFLGVCFVVRAIFLTYKNRTLPKIDTSGKTVVVTGCDSGFGLGLAQRLHNRGFTVFATCFSLESNGAKQLSGVNSERLKVVPVDVTNDDSVARCLRVVREQCADKGLWGLVNNAGQNFVGDCELTTMTQYLEIANVNLFGMVRMCKAFLPLLRQAKGRVINVTSVKGLFAIPANAAYTISKFGGEAFSDTLRQEMTQYGVTVCIVEPGNFGGTTGCLNEAGIKTLKRFFDEQWEEASEEVKEFYGRAHLQQELDDAKTSALTGCTTINPVLDAFEDALRNQSPKYRYLVDGSKSYIDVYNWLARLRPYLPSRIFNRLRAYFFSYSVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W150</accession>
    <name>A0ABM1W150_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Espin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101845722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828393.1">
        <property type="nucleotide sequence ID" value="XM_035972500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845722"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178:SF9">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178">
        <property type="entry name" value="MOLTING PROTEIN MLT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="607"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="471"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828393.1"/>
        </source>
    </evidence>
    <sequence length="929" mass="100837" checksum="F15DBAF4B0B124FE" modified="2025-10-08" version="1">MVSDPAFEAAKIGDLETLKKLPGVTERLVDDNGAGCLHFAARGGSLVVIEYLIKTLAFSALNRSKTGASALHDAAARGNTAVVKWLIENSEIKVNDQDGSGVTPIHLAARYGHFLTVEWLLDEADADISVRSANGALPLHFAVFGGDVNCIKILIDENPRLINMQMNNGITPLYLACQSGFLEVAKFLVSRNAASKIKAYDGMSCLHAAAQLGCTDVVQWLVKEDGSNPNDRDFDGATPLHYAASRGHAHLVCWMMRHGGFKVTLDNLGGSPLHNAAELGEMQSVQALLECGCDVDLSDNAGLTAAELADDCHQTQAAALIRGQLSPPPSPPPPPPEPDTLRADCLPTDRVGHLRSPHLNFPPPPPFPPEEDTEVDQIFTRAHNTASTTNALNSNNNSSNNNSTISNGIVRGSSHNYNGYIHQHHSSNIYNNNNDQKNSVPYNNNNNNNNSNSNSNSNNRNSGYTHTGHQYYSNTTTTTNNNSTNNYNSTNSFFKSAPLHSPSPPLPPPPLAISPDASSPSTVGSPISPPTPLHEAPGFGSPYHEEAQETVSRLHSEVEGWAHAPRYSQDLGTEPLIRRTVSRISVDSSASNFGVFEVQEGAVLHTGSPQTTTVRPLLSSSGKLSTLPSSEDRADSPPLPPPPPPIASPDLESLASEVSGSTTVSPPATDVQFPSDVTTRGEGRANEIVNRSPVYQRGRDPGRYPQQHLKELKSDTQNAFSKARALFGQGDNQPQHSQPQYSQPQYSQPQHKIRQLFSLPSPRSPTQKTYNREWSSSSTNSQPFSPVESKHNLIADIQSAVSGNSSLSLRRAKSRGEGVSMVYQSSKAAKRNGGETTPVSESKPLTGEFDPKNFLDKVEKIDSTGRPIPEWRRQVLAKHAAEKAQKDFEENKVVEDYEARFKDMPAWKRALIERREAQAKEEEARLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2H2</accession>
    <name>A0ABM1W2H2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C-C chemokine receptor type 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118478774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828865.1">
        <property type="nucleotide sequence ID" value="XM_035972972.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478774"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="48"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828865.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22807" checksum="D637BF5B3C0FFC06" modified="2025-10-08" version="1">MNSSKIANQFPTDKAMARIIVGEDAARQMTLVINCILTQIVTTVGSSCNLVTVLVLRRHGYRDPTNLLLLSLAISDLLFLFCLWLRKLQCPLAYIAEMVGGEDNFMLAKRYDAYVMVHGVFTVYRVAMFVSMTHVVLLTFQRFLVVCFPLRVSQWLTFKSTLAALISLWALIVVADACLVARLHFSLIDIIQIIQESGFDPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2N0</accession>
    <name>A0ABM1W2N0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC101854055</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101854055</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110915.1">
        <property type="nucleotide sequence ID" value="XM_005110858.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828923.1">
        <property type="nucleotide sequence ID" value="XM_035973030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854055"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005110915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828923.1"/>
        </source>
    </evidence>
    <sequence length="805" mass="91397" checksum="FEA26331E62937B6" modified="2025-10-08" version="1">MSVTATKNKGMKKFVMDNKGFIDNLQDHEISKTFAFGNVCQNCSLLCDYFSAGGNLNARDSKTGETFLHMLCNYTHLYLTANGTRIMYLLCTKLDPDVTDLRGDTALHKVVRVPGAWRCIVALLRCGSCPLIKNNAGRTPEDEILHLKNTGWQENLHWLRKFKPGLWAAVKSQNPDPVLIERLLRYWCRTTKIIGKETVNLKCLVHMCETQLDTVLILEKYENTNEMALAMLSGKTHFIDMWKLAENLQKVDINTKDHSYQFYYRDYPTAPRPLMAAVWEIDQLELIQSFMELHPDTSIKYTFESEATSPPKPLFFQLVNPKSRPQNEAITSLILRDADLNIRNTQGQTVLMEAMYNGETEGIIRAILNSGVNVAARDSNGRTARDHSILLKRNDYRELIDSHIIEMVQDCDILRLEALVLQLYEHVAPVCARHQLLCIARQKCSKQLHELLKNAAGTQAVVKKLFSFVKSGNKVQLMRQMTRKYANARDKAGRSLLHFAIQHSLTDSSGKTQQLPPRGLPTVRGDVIMDDISVRGVAIESLEDPTHNSDTTQLHGRGYRCRVLDSVKKECNRFKKNRCLFSKCMNQDNFTPDHVGVIKYLVQEFPFMLGHSNNLGQTPLHYAYIYTANQEVLDLLKTTGSCEHIKDVYDFVPEDYDYLQCGVQTFNVRRKPAVNVDLDIFLTESDFEHQFVNAVKNGDQEEVKKLLVPLLEHGGESRFSCVLFDCLDKGYFDLASFLVEAGFDIDISKQYEVCDPDDPMCAMMECGHASTTFKQRAEELGATSLVRLIDSISLAPTRTAVHTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2N2</accession>
    <name>A0ABM1W2N2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: uncharacterized protein LOC101858449</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828925.1">
        <property type="nucleotide sequence ID" value="XM_035973032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858449"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828925.1"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110833" checksum="09F8E36CC34C9C51" modified="2025-10-08" version="1">MVGLADTNIVGATDEVKRKTSYCSHDVMNRGRAPHDRPATAQQGEHEPRSGVMLARPDHVRRQQTSSSVTRNSTHVLYTVSATDTSHSFSNSSNTTDSHGKLSREARFYESYNPSTGVHTAAVLGGILIWLVLYVIYRTKIRKCVITLVKKKLGSFDDIDAKKSTDSENNSNTASNPNTVRALINPSIIIETSPPESSPKSPSTYEQYMKGGGHDCMSQHGCGLHEENMVFQFPCPTHGGSTQQLHTTNCQHQSQLHLQLPKSEMDIPSATAQWVQNMPLAARSHQDFAKLMMHIQSRGLLAMHKPCSCPHVPAASPAPLPLLDLPTTWNKSLPVLSSSVSSQLMSAYETLNNNHVTRTKDLKELLNAKRRQSSQENRGMSMDKDEGHDEYLKKKKHSNRRQSSADVKQAENQHNQRKKRSSRNNPNLTIQIPDPKETATLINNASVNRSPMPIPVTPTVMIQNSAPKVPPRRQGCGGSNTSISSSSSTDLLLGPPIVAPVQISYPAPSSRIPSPHLLSPACDTRTHGGHRRNSQHFTWSQEDLHRYHSTPGNLPAPSPTPRPPAQHPCGLSGHQCSFKYKKRDNKCVSPLATSNCPEMRRYKSLSDQYFQNVANANENASNVNTLAQHRRSMSDYGSETPDNSHFVRRHQRSLSADVAFMNLQRDLGSPTYSNGSNKNSLPASSPSPNRLQVPDPSGFYRPVSPEVVNSNINHRTGTVLVGGGGSGRYSPTAQSALMRRFVHSDSNLAYLSDQFFPASGLWPDSTAPATPRRHSSTVQPSVVDSNFLYCCETSSRPTSSLSRHSLLSPASPPSPYPASSASPQSPHLSRHHHHQQQVDNKAKQLPLAFALTSGKRRRDYQAVLPALKGELRRLHGEDAFFSLEAALAYVRLTWLDNTLWHPSSGSAFYWFVRTNKDVEGWHHRLNSKAAXGQLSSVSAASTLVQGGCSRISKPDPVRESAIIRRHRKAAKNATRKLFKLWDQLIAREKTARQILRAASKLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4B1</accession>
    <name>A0ABM1W4B1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">A disintegrin and metalloproteinase with thrombospondin motifs 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101858466</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829504.1">
        <property type="nucleotide sequence ID" value="XM_035973611.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858466"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF200">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 18" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="15">
        <location>
            <begin position="404"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="16">
        <location>
            <begin position="1535"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1262"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1302"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1303"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1324"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035829504.1"/>
        </source>
    </evidence>
    <sequence length="1587" mass="177761" checksum="F00201B76A6E5786" modified="2025-10-08" version="1">MWLSGLDGLPTLASCRQREELADSPCAHRHSNRRSLSISTEDTSDSRLRHCCHRHQSECTGIDDDISFIAHNETVDPSASQCSRQLVCAGDVMVKDSSCLVCRSAGTPDSTASATTSTTTTTTTTSTSSASSSTRLALSLFLVVSLLNGTSAAVTGFHFPDIKQERFARDLSQFHISWPSRVDHQGEFVSHELQATDNLVRKRRSAGDPLDIGVPLEGESSGQAGEDLVHYKISVDPKRDVIVKVKESKLLVAPGAVIERKVSKFKNVSDSVFSTLDHQKGCHFTGEVPGQSSSLVALHTCDGLRGFLQLDEEEYLIEPVKGHESSSIGSRPHLVYKRSAIPEHLDFVSRSKRHEPACGVQEEYNRVLEHRERWERRRRSTSRAQSSEKTSGHSRQKRSISIERHVETLVVVDPEMVQYYVYEDIETYVLTVMNMVAALFHDASIGNAINIVIVRILLMQDPDEELKITHHADKTLKSFCKWQKNINFRDDDHPNHHDVAVLLTRRNICSRMNEPCSTLGLAQVAGLCQPHRTCSINEDTGLSLAWTVAHEMGHNFAMKHDNGQDNCKSDDVIQYVMAPHLTWDKTPSKWSSCSRASITKFLDRNWGYCLDDPPGLHEFKYPELPAGTMYDADHQCRLLYGDGAERCNGIEVLENICTTLWCRVNNKCSTKLQAAAVGTICGKNKWCFAGQCVDIGERPQAIDGQWGQWQEWTSCTRTCGAGVSLSQRQCNHPPPSNGGRYCTGERKRYRICNTDPCDEEAQSFRAQQCAEFNKLPYKGSKYEWEPISTPETPCQLHCKPKDMFFSVLLKDIVTDGTPCVMGSRHMCISGRCRHVGCDWILDSSATEDRCGVCFGDGSTCKTIKQQFKETKKLGYVEATVIPVGARNIRVEEVAEASNFLALRNDAGEYYLNGHWFIQWSGDYEVAGTVIHYKRIGNREKFLAPGPLKEPLHIMLLMQTHNPGVEFEYTVPKENATDNRKPEFSWDFMGWSHCTVSCGGGKLWTHNSLWRRILVIRILEDSVFWNTKRSITLCIHTKISVLFPLYKILLKVNGTFYAHFSLVFTTGTQRSAVVCKEQEAGLVDEMFCDSNTKPDDQLRECNAHLCPARWWTGPWQHCSVTCGDKGIHRRTVICVRSLGSDEQIALEDEACGGLEKPVEVEPCHHKDPCPGLGVWVVEEWSNCTRPCDGGVQFRKVICTRGSHCTAGKPDVKRSCNEHKCISEVEEKMLDISEGGVVLSDSTLNSPLPASSDFIPYVNGSAVLPPGDNDNNNDSKNVLIGDSYKSYTPPGANVDFELTNQDTNHKHKHRYHRHHRHHNKNHHKKNNEESNKADHDSGKKGEEDPTSNNTGNSGPPEELQGTGDNSKFVWQTLDWSRCSRQCGKGVRTREVFCIQAHTGGRVGLDFCALGTKPSTIEECFESECLNWQKGDWSQCSATCGYATQQRQVLCDNPGRCDDRQKPASVRECKDLGPCIAWVYGGWSQCTKSCGTGIQERLVQCVNLTSQQLAHGCKADRKPQRKQQCNEQDCPDNVNAALSVSCESNDLNYKVCRMLKKVGLCHKQYVQAKCCRTCADHSRPKPHKSKMARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M4VRP0</accession>
    <name>M4VRP0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Neuronal acetylcholine receptor subunit alpha-10-like precursor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="19">Nicotinic acetylcholine receptor subunit type R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC101857921</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="J. Neurophysiol." volume="112" first="446" last="462">
            <title>A potentially novel nicotinic receptor in Aplysia neuroendocrine cells.</title>
            <authorList>
                <person name="White S.H."/>
                <person name="Carter C.J."/>
                <person name="Magoski N.S."/>
            </authorList>
            <dbReference type="PubMed" id="24740855"/>
            <dbReference type="DOI" id="10.1152/jn.00796.2013"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KC411666">
        <property type="protein sequence ID" value="AGI03858.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001297423.1">
        <property type="nucleotide sequence ID" value="NM_001310494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M4VRP0"/>
    <dbReference type="GeneID" id="101857921"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000043">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15 21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022251118" evidence="15 21">
        <location>
            <begin position="22"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="43"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="256"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AGI03858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="NP_001297423.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61386" checksum="E54689B49AE27863" modified="2013-05-29" version="1">MNAVSVLLILLLILRCPASLAHQYPRYSPHREIEVEGLPATDEQRLLSTLTFNYDPAVRPVFDAKMPVIIKLGITLTQIIDIDEKNQVLTTNVWLDQEWTDEKLKWNKSLHNDIGILRMPCDFIWLPDIVLYNSVDNHNKGYMRSLAMVHHDGTVFWPPIVRMRSSCKMDITFFPFDDQLCALVLGSWAYDGFQVDVTNRSENVDLTNYVDNGEWELLGTKVIRRVKNFTCCPEPFIDVTFYLMIRRRVLYYFLNVIIPCMLLSSLSLTGFLLPPDSGEKVTLGLTVLLAFSVFMLLVAENMPPTSEYIPLIGIYLTVIMAMSALSVALSVFVLNCHHRGTSMHRPPRLVRGMSIAVAKMFCMRLLYLNKSVNVNNTHSFGASDRQTLIDDPHFTPPPQQSSGIHYQSTLSNNSRNSTQITPTSSLHDMTSQPIIDEADNSGRSCNGSVAAGSAHRTTNSGRGRLNSTRSLMEGQILYYLKSVLEAYDRGHGERTAVLEWQEVARVLDKFFFWLFVAITFMTTVFLLLISPITKHLEFPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAS3</accession>
    <name>A0ABM0JAS3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta-1-pyrroline-5-carboxylate synthase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Glutamate 5-kinase</fullName>
                <shortName evidence="16">GK</shortName>
                <ecNumber evidence="16">2.7.2.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Gamma-glutamyl kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Gamma-glutamyl phosphate reductase</fullName>
                <shortName evidence="16">GPR</shortName>
                <ecNumber evidence="16">1.2.1.41</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Glutamate-5-semialdehyde dehydrogenase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="16">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101852520</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>L-glutamate + ATP = L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 16">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">In the N-terminal section; belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="16"/>
    <dbReference type="EC" id="1.2.1.41" evidence="16"/>
    <dbReference type="RefSeq" id="XP_005089394.1">
        <property type="nucleotide sequence ID" value="XM_005089337.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852520"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04256">
        <property type="entry name" value="AAK_P5CS_ProBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041744">
        <property type="entry name" value="G5K_ProBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005766">
        <property type="entry name" value="P5_carboxy_syn"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01092">
        <property type="entry name" value="P5CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036429">
        <property type="entry name" value="P5C_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 16" id="KW-0521">NADP</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 16" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="18">
        <location>
            <begin position="57"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="17">
        <location>
            <begin position="336"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005089394.1"/>
        </source>
    </evidence>
    <sequence length="782" mass="84643" checksum="75880CB2D1664063" modified="2025-10-08" version="1">MLRHTTASFLRGFQNLKCVNSTLRISSSRAYSSTEIVELDLSQSSAALLRSDLNKVKRIVIKLGSAVITREDECGLALGRLGSIVEQVAELQNQGREMVIVTSGAVAFGKQKLRQEVVLSMSMRQNLSSIENGGAWIKSRPPSLEPRACAAAGQSGLMSLYDAMFLQYGVKTAQILLTKPDFQDESSRENLRETLSELLKLNIIPIVNANDAVAPPPEPDMDLAGVISVKDNDSLAARLASEMKAELLVIMSDVNGLYTAPPGMPDSRLLHTYSPERDQVIIAGKSRVGTGGMDSKVKAATYALARNCSVVICNGCEENAIVNIIKGKKVGTFFTKAQARGTPVELQAKNAREGGRCLQALTGVHRTAIVNRLADLLLERKSEILQANQQDVQQAFAAGMQQSEMARLYLSDQKLETLATGLRQIGKDSVDAVGRVVQRTRLADGMVLDKKTVPIGVLLVIFESRPDALPQVAALSICSGNGLLLKGGSEATHSNKILFSLVQEALEPYAPADTVALVSRREDIADLLHLNQYIDLIVPRGSEQLVSRIQELSQGIPVLGHSEGICHVYIDEDVDPEMALHIVKDSKCDYPAACNSMETLLIHKSHRNGTLFDKTCEMLRLQGVKIHAGPRLGQVLRFGPSLAASMRTEYGNLECAVEIVDDLDDAIAHINKYGSSHTDSIVTNNDENGAQFLKMVDSACVFRNASTRFADGYRFGLGAEVGVSTARIHARGPVGLEGLLTHKWVLSGSGQAASDFSSGKNSFVHERLPVYGEYEDSDSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBD8</accession>
    <name>A0ABM0JBD8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinone oxidoreductase-like protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089767.1">
        <property type="nucleotide sequence ID" value="XM_005089710.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851994"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042633">
        <property type="entry name" value="CRYZL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44461">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44461:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089767.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="38429" checksum="CDB61FFF9F2C86D1" modified="2025-10-08" version="1">MLLTMQTLRGNFIGPDAVLTNEEHGVPDLGPNDVLIKVKACAVNLEEERRYQQLLTSSLKSCALGRDVAGDIVKIGSQVESLQEGMAVVGFVSFDFELAGCGEMCICNQFDVVEKPSSVSYELAAASIGAGLSAYTAVHYQGHVTAGDTVLVLEGATPRGSFTVQVAQAWGAKVLSTYKTQGEKQILESMKPPVAQAIELTQRTNILASSVQEETGGVGVDCIIDNGVRLFTNEEDKDMMEERALRSVPHKQDIIGSLGFSGKWVSSQPNLQLDPPDSQQLFLRGASVSFLFPPAWCLMKAQHGRFLHILKDIMDRIQNGEFRCNEVLSIPLTEAPEVLSRKDLDSTKSLVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC57</accession>
    <name>A0ABM0JC57_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101850769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090304.1">
        <property type="nucleotide sequence ID" value="XM_005090247.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850769"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005090304.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9107" checksum="0F6246239D721667" modified="2025-10-08" version="1">MQNDAGDFVDLFLPRKCSASNRIIAAKDHASIQLNIAEVDETTGRMTGAYKTYAICGAIRRMGESDDSLIRLAKRDGVIAKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDU9</accession>
    <name>A0ABM0JDU9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine kinase receptor Cad96Ca</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091416.2">
        <property type="nucleotide sequence ID" value="XM_005091359.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859381"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="130"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091416.2"/>
        </source>
    </evidence>
    <sequence length="437" mass="49708" checksum="90FAEDD97418DB92" modified="2025-10-08" version="1">MLDVQGQNAAYIVRNHDPAHTGPQVADTNMHYSSARASPKSHTSIFSPYAVGAVISAGLAVLLIIGFVLMSMRMKKREKRMREKMARAHDENLDDQEVELLDESTQPNTEYLPTEYSRLKMSWEIPRKDVRLLEQVGQGAFVEVWKGRMRRSPGSTEVMRVIIKKLQGEASEKERHFFTAELEVLKMLPAHANVIRLVGSYTTHEPWLMMMEQASEGTLQQFLQRHRPGHQQVMIGRGDKASVSMRKQMLTAQKLLALAAQVASGLDHLEKFKLIYYRLRSCKILVAKGGICKMSGFGFANEITDRNIYEVNCVPVRWSAPESLQHQLYNIKTDTWAYGIVAWEILHFGTTPYPTMGPQEVVESVHTGFRMPKPQHCSSELYELLLRCWHTLPEERPSYQEILEVLSHLVVNADLHIDFSGLPDHLLSLDTADNAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEJ1</accession>
    <name>A0ABM0JEJ1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein C10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0456 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091907.1">
        <property type="nucleotide sequence ID" value="XM_005091850.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852225"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026317">
        <property type="entry name" value="P_C10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13463">
        <property type="entry name" value="PROTEIN C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13463:SF3">
        <property type="entry name" value="PROTEIN C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14974">
        <property type="entry name" value="P_C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005091907.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13647" checksum="83A2D1CB25A0E411" modified="2025-10-08" version="1">MMALGKHQFSLGDCKAALREILETFSQPENVTKLEEVRSAAGNDMLKSMQTVFPAATQMQIQVVQRYGFLPDGEGLVQFTKAVRGYEEQDQEVRQLNSQLRNFLLPPVSVPHPVAPILSGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFY2</accession>
    <name>A0ABM0JFY2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase</fullName>
            <ecNumber evidence="5">3.5.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Peptide:N-glycanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101859388</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue.</text>
            <dbReference type="EC" id="3.5.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.52" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005092800.1">
        <property type="nucleotide sequence ID" value="XM_005092743.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859388"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1020">
        <property type="entry name" value="Peptide N glycanase, PAW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038680">
        <property type="entry name" value="PAW_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006588">
        <property type="entry name" value="Peptide_N_glycanase_PAW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04721">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00613">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51398">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PAW" evidence="15">
        <location>
            <begin position="445"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005092800.1"/>
        </source>
    </evidence>
    <sequence length="653" mass="72805" checksum="87F6F9B522F977C3" modified="2025-10-08" version="1">MASSTVDYAVKELAEENSVTEFLTAADILLKFASNVLEHPLESKYRRIRIANQNVQNKLLNVTGGIECLFAMGFQEADDGECLLLPQNASLQQVGKIKADLLTERNRVSGTSQTASPPAPPPSSISAASPAVAESRASSSAAISSPAQQNFNMFAASERDFLNRIMGAMSRVQNYEVQSSQERARAVIPIERLESEAKAKLASLQQEGSNPGLNVDLQDCLVLALLRWFKQEFFHWVDTVPCELCGGQTRNTGSLTPVESDLRFGASRVEAHTCDSCSHVSRFPRYTNAVRLLETRRGRCGEWADCFTLCCRALGFEARYVLDWTDHVWTEVFSVAQKRWLHCDPCENVCDKPLLYESGWGKKLSYVLAFSKDDLQDVSWRYSGKHSELLSRRKACRESWLQRTVHGLWKKKLATLPEARQSELRLRLLQELVEFLTVKTGSGEVLPGRTTGSLAWREARGEVGDGAAAAAAVASTKDFVFSPTESERESEIIHVCYNCAEDKYVRKSSGNAQQVGWLACVNSSSNVVRKEEHDWKMVYLARQNGGSSAEISWKFDVTDTDLRISKMELKASTAVYENGKISWQICAGDNCFSQNGASLQDFMTFDLHGTKTLTITAVMRGGKGDVAWQHTQLFRQSLQTQGEFPFEVRLFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGP9</accession>
    <name>A0ABM0JGP9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC101852390</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC101852390</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093291.1">
        <property type="nucleotide sequence ID" value="XM_005093234.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093292.1">
        <property type="nucleotide sequence ID" value="XM_005093235.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093293.1">
        <property type="nucleotide sequence ID" value="XM_005093236.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093294.1">
        <property type="nucleotide sequence ID" value="XM_005093237.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852390"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005093291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005093292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005093293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005093294.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18418" checksum="7C6323C911F64909" modified="2025-10-08" version="1">MAHGRWPYPNDISPDASPMSSQDLEDKNYVVIQHATNVVQGNLTVIHGEPRSQQKQRPRRERKPKKPITESTKPLNQDQKEGISKRVGDDWKRLGRRLGFDNALLEQWELEKKPDYTELNYHIITNWEQEKDREATCATLAEILYKKLGRGDLADLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGS7</accession>
    <name>A0ABM0JGS7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC101863728</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101863728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093339.1">
        <property type="nucleotide sequence ID" value="XM_005093282.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093340.1">
        <property type="nucleotide sequence ID" value="XM_005093283.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863728"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19724">
        <property type="entry name" value="bHLH_TS_ASCL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005093339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005093340.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30794" checksum="B3097E2532E81FCF" modified="2025-10-08" version="1">MRQLSPQCPSSGIPSVVIQKLSDCGRSHKMSHDSPYTRDFMPTCGELGIPLMDDCRVADFAYCNNSTSGNNNSNSMGVSVNRYSDHGSGVYSRDCVVGLSTPDVFRFGRLIHSPGLQIDGLKYESQTYRVDPYSPVCMVPLPGHMTEPTFVRRRNERERERVRCVNEGYDRLKEHLPLGNKDRRISKVETLRHAIDYIRGLRQLLQDTERQKQHTDKQHSNKHTNKRTYKHNNKHATSISHSPHEDAAGPAHKRRRPSLTSSGHGSPESDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHJ7</accession>
    <name>A0ABM0JHJ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Zinc finger protein 62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC101849678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005093808.1">
        <property type="nucleotide sequence ID" value="XM_005093751.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093809.1">
        <property type="nucleotide sequence ID" value="XM_005093752.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849678"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="701"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="824"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1020"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="949"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1152"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005093809.1"/>
        </source>
    </evidence>
    <sequence length="1182" mass="132684" checksum="111F372D6EEF832E" modified="2025-10-08" version="1">MEQQTVTMMSEEETPEVGPNDIVIHLVNPYKCGQCELEFLEKTVFKEHMFSHLEQIKQERPSSQIVMNITLPPETPGGVTVTRDILQLGEDGSIKQVLQPANNITLNQVSPLRELEEAGVIKLDPPKPLEPVIHSVKSLTQPVQQVPKMNAMTTTDTTNAALGLLRSAAVGEQAAAIVQQTQTTDSAVPGGMAVLGGDGMEGLVKAAEEGEETEVSEIVDNKDGSFSVAFKGPNNEMQHIQILRPEGMKGDMMLELTNVQGRRRHSRSGVTTKSNECDICGKVLSSSTNLIRHKMYHSSERPFVCEVCNKGFKDVSNLKKHTQIHKRIYPCFLCKKSFLRKSLLAIHLKRHEARTTFVKTGSSSKEVTMRTFVDGDGTRVEEMSMVALAGQTFEYKHRIMKADPAEVTGIKKEEDNSSESGVVDTGTTTNPETEVLTSAADEAEGKVVGNSKPLFTVTSGGLREAGAPGEEEAAVGTKPNTDGTEGMDVDDLPDMKIPPVPEEFVKLYQCGHCGKRTVQRGNMMRHLIHHLKDKPFVCDECPKQFVDKGELVKHKKTHTKPYRCHQCNGAFAHNVQLIKHLHSECLGNSENLNYTVLDDGKTYKCDICHIEMKRLGNMIKHVSTHSYDNKRSSWPHRSLQTPKAVKSSNSEQVSPATQSPNALYYFDATEQAFFCSICLKMFKQRANAHRHVKVHIKEKPFLCQKCNKEFPNSNALKKHVLMHRRPYRCDMCKASFSHRLLLEAHKRKHSDKERDEETADYGVLEDKSGYYCKHCDKKLTKKYRMMSHIRSHLNQRPFECQICNKCFSCQYMLQKHKKSHATPFICDKCGVTFSRKFFLNMHKKKMHCSEEGIEEEETGMDGDGKEFLCSICKAPFSRVVIKMNHEKKCREESKVLSRLPSGKGFKCKICNKVATLKHNLMVHIRKHEDAIRMDSSGRITLLTGALGEDDKNGGKKSFPRSMSMLTKRSRSPRTPRKSLISQMNQDMEGSDWEGMEEEVLVEEEQEKELDERCQRTPGGWACTICRRKFTDKDTLLRHLESHATKENSQKEEGKEENSNEEEAEKKETPDAAPEESTDEPPLETSKTQEASDTPLPKVENGNTPATTGTANKKLRVRGKAPFATTPATSRPVKDPKSLKSRAAETAAKSELQESPGSSQEGTPSRSAHRPSRTQKIPSRFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN00</accession>
    <name>A0ABM0JN00_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Cadherin EGF LAG seven-pass G-type receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16" type="primary">LOC101845166</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005097489.1">
        <property type="nucleotide sequence ID" value="XM_005097432.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005097490.1">
        <property type="nucleotide sequence ID" value="XM_005097433.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005097491.1">
        <property type="nucleotide sequence ID" value="XM_005097434.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825447.1">
        <property type="nucleotide sequence ID" value="XM_035969554.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845166"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF321">
        <property type="entry name" value="CADHERIN RELATED 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 14 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021096" evidence="10">
        <location>
            <begin position="34"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="49"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="148"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="250"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="421"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005097489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005097490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005097491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035825447.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="62446" checksum="07AE1F4EA93EDB2F" modified="2025-10-08" version="1">MAALPVSSQLFSAPRVLTLLIVISAAIATVTSARPKNRAPIITLGLPYSEQPGVLKLSEEAPEMSLLGLLKINDSDTAECTTDNEFVGLGFVSDTIYKIELQRFLDRELESEVNVRFECVDTGVPPATGVATFTILVQDVNDNVPVFQREHYSAQVAENVQYGTLVVKVEARDMDGGENGIVSYALSEGAREAFRIDAKTGEIFTATDIDREEVAQMSFSVIATDMGEPPLSSSVNVTVTIDDVNDNSPVVLTNEFHVQENQKPMSVVGTLRAVDLDEGKNGEIVFSKFDDSEDDSSSTLPFLVKPNGKVVAVVSLDRERRDTYMMKVLVKDKGRPKRSSTSVVNIIVDDVNDNAPELISPCLEEPWRGMNFRRRRRNADEGYETVRDDAGESPEGMDKMENVTSRIFDIPGFVTIDWHCPEGERVVYQVKASDADIGINQAIFYSIESLNGQGDVDESEDDTLFTVDASSGNIFLRRYFRKTDDLQQLLNISVRDSGNPSLVSYCALNVTFDIDINEITVPTDPERAPNTIGDDGGPENGAGLGAMNVTILGLMSCLLVLYNTWVFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNL9</accession>
    <name>A0ABM0JNL9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097906.2">
        <property type="nucleotide sequence ID" value="XM_005097849.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858937"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF83">
        <property type="entry name" value="CITRATE SYNTHASE-LYSINE N-METHYLTRANSFERASE CSKMT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="82"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005097906.2"/>
        </source>
    </evidence>
    <sequence length="321" mass="36095" checksum="EC66A6DF7BBB26FD" modified="2025-10-08" version="1">MMWSRLTFTRKKLYATGRHFLSSEEKLSKLSFWKSQYQKQSPDPGFDWFVGPENVTNILQHHMQELWSVLCGSNSKPSSEIKSQFMYLELGCGTSLVPHDVIKTADVPVSAVLLDYVHEALAFQRQNFDVNKRGGNRHALTVCADVMSLPLKSCSFHLAVDKGTMDALLRNRQHGKSNSQAMLSEALRVLQRGGRYLQISDEDPDVRIDYLDSLWKSVWPKVCYSNSSNADSASRNLKNSVDSTGEKNTQANSYLCESNLVRNSSSGVKNCVSSGNLSSAENSELCDKTSLVDSSCPLGSWSFKVVPSQWGQEYFVYWRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP42</accession>
    <name>A0ABM0JP42_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Splicing factor 3A subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101855946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005098228.1">
        <property type="nucleotide sequence ID" value="XM_005098171.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855946"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025086">
        <property type="entry name" value="SDE2/SF3A3_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13297">
        <property type="entry name" value="SDE2_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3A3" evidence="9">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2/SF3A3 SAP" evidence="8">
        <location>
            <begin position="226"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor SF3a60 /Prp9 subunit C-terminal" evidence="7">
        <location>
            <begin position="387"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005098228.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="58257" checksum="FC71D08A8033423C" modified="2025-10-08" version="1">MESILEQQRRCHEERERVMEAMTSEMLLQKKTQREQINSDHRLKVLHDRYAETTRELKELYEDKDGVRREEIQTLAGPNEYVEFKKRLTAIEHFYKQHPNEVSIPMSLEFDELAKQREAPTEESQNMVDFTDEEGYGKYLDLHKCYEQYLNLKGVEKIDYINFLSTFDHLYDIPKDRKNAAYREYLVFLLDYLGEYMSKIKPLTDLSDEVEQVQSEFDKIWSEGMFPGWPKEATGALTHSGAHLDLSAFSSPEELASLGLDRLKSALMALGVKCGGTLEQRAQRLFGTKGKNLEELDPSLFAKSKPGKAGKVGKNKDSEKQREIALLEAQVYRLSELLSEQRSATRDNVQRKQAQTGEEREESDDEKYEESDSDDEGEDAPYNPKGLPTGWDGKPIPYWLYKLHGLNLTYNCEICGNHPYKGPKAFQRHFAESRHALGMRCLGIPNTAHFANVTSIEDALALWTRIKSGKEAERFKADTEEEYEDSQGNIINKKMYTLLKKEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPA2</accession>
    <name>A0ABM0JPA2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleckstrin homology domain-containing family D member 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098346.2">
        <property type="nucleotide sequence ID" value="XM_005098289.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863897"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098346.2"/>
        </source>
    </evidence>
    <sequence length="313" mass="36614" checksum="A790BE7BAA151714" modified="2025-10-08" version="1">MFVTDRLQSEVLALSEEKMRSEELEKVNQELEKEKRKLETFTKEIQEEYEKIKSEMTETADLMKQVEDDRVTLSQTLEEQRLQLESLNKDKQHILKELNHSMAEQSSLAEERNSLSARSQELQAQLADIENQTQAVQEDRTDAELRLKDNEERLEQLEEEKATISQHAHELETTIHDLVSQKELTERELKEEIRARISAEERLKEAEKSLTSLDRAVTSQSHRIETEAKEEMTCSVRKLKDFFEDLAAEAKISSEQPLIIRNGLMARKTLARRAKTVRYENKKKSSNNRMSCDLLRPQQPRTPLRRVVSTLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ04</accession>
    <name>A0ABM0JQ04_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Corticotropin-releasing factor receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101858628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098840.2">
        <property type="nucleotide sequence ID" value="XM_005098783.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858628"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="11">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="117"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005098840.2"/>
        </source>
    </evidence>
    <sequence length="226" mass="26066" checksum="D0CE278DE1BCA1FE" modified="2025-10-08" version="1">MADHNETHCETWYPSISIEPGALYCPPKHDGIICWPATRANTTAYRLCIDLPRHEDDPVIPGNTQAHAHRTCLPSGEWLPYTNYSECLDAYANYSITTQLSTQPPEQDITRQAARTLSMIIFIGSTVSLVVLLLSLLIFLKFKSLQCQRTSIHKHLIMSFIIRFTIITVMVEPFVFGHNPWYKEMEWLCRTLTTIQYFSIVANFCWMLVEGLYLHLILVLRPMNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQN8</accession>
    <name>A0ABM0JQN8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101862417</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099277.1">
        <property type="nucleotide sequence ID" value="XM_005099220.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862417"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046764555" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="28"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005099277.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="38351" checksum="96D07F4F1F44185F" modified="2025-10-08" version="1">MKNLIMRSWMLPVLLLVLGTVTQNAGAFGDYNSDKILLSDLKALTLHQGQMTNARRSPPVPQLKCVGGSAQHRFQPKVVQCINQGSNGYDIQWECKTDMDNNYRFGHVEVSCEGYDYPNDPYVLKGSCGLEYTIEFTEEGLAKEKQRGGSSYSSYPTSHKSEGGVGGLFMFLAILCVMYIIYKTCIAPDVTPGGHRAPPTGTAQPPPYGFRPEFQAPTGPPPSYESTQSSSYCDPGFTSSAYSRASAPPPFSSNTAEGTGGGGFWSGAATGGVLGYMFGQGNNRHHYNNSHNRGWGGSGWGGSGWGGSGWGGSSQEHHHHHHHRSDSPSGSFFSKSSSSPSSGSSGTRTASGFGGTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQV6</accession>
    <name>A0ABM0JQV6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854868</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099419.2">
        <property type="nucleotide sequence ID" value="XM_005099362.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854868"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045708270" evidence="1">
        <location>
            <begin position="22"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099419.2"/>
        </source>
    </evidence>
    <sequence length="524" mass="59726" checksum="530AFF32D28A5A9D" modified="2025-10-08" version="1">MSPLSLCVSFLFVLTVSVAQGRDIASNLHGIAFAAVTTEDAQRAARWYSEFLGAKHLTDLSFSFYGDEHYYRFFQKEILEARAQGIDPDRLGVPDISDNGNYEIRGEFVLFDNGLVQLIEFARRDTEEHITYPRRIRLTGPGVRNAPQICLWTKDDLDFNQFVHELEEKSIKAGYDKAIFNRAVKVKNEEERRNAPIKDKGINVKEGPFAGLSFVYMKGPSGEQLELYKMVNHTRWHFGKEYCKRRGVTTAFLDNYKDNEYKKKAGLTGQMWGLVQFGTHTDDLFGSVNFYSNVLGSQTMEYPMQAIDLKGDPFKNMLYQKETLEAARLGIRPREFGILDVSANGGGRIDYRFNLFDNYHVETLRYTDGPTMDYPSFPVAYNHSSLAYVGDMAAAFHVNDNADFNQLVADVERRAEELGFEGVKANRVIDVRRLGEMVDLSEYSRPFTSGNLEGYNYVVMKGRSGEHIMFVQLRGPMGEKVKQAMLEYGAVSTAWPETNPWTYGGYDEFCSKYHNLDASPKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQY1</accession>
    <name>A0ABM0JQY1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell number regulator 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099460.1">
        <property type="nucleotide sequence ID" value="XM_005099403.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863986"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099460.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11767" checksum="517FD3CA8D2192C3" modified="2025-10-08" version="1">MSAEWQHGLFGCFDNIGLCIISYFVPCYQFGKNAEAIGESCFTCGLAYILPIANIIAALKIRGKIREQRGIAGSTFNDLLLICCCPLCTLVQEAQEVQVPGAQSMARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSQ2</accession>
    <name>A0ABM0JSQ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Merlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005100626.1">
        <property type="nucleotide sequence ID" value="XM_005100569.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859712"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046810">
        <property type="entry name" value="ERM_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20492">
        <property type="entry name" value="ERM_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002305">
        <property type="entry name" value="ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="5">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="318"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005100626.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="69395" checksum="4689B42FC693F1F2" modified="2025-10-08" version="1">MPKMTMTKASKGNAKQFPVRVTTMDAELEFTIEPKTTGKELFDMVGRTIGLRETWYFGLQYVDSKDYVAWLKFDKKVLDQGISKESQIQFTFLAKFYPEEVSGELVQEITQHLFFLQVKQSILNMDIYCPPEASVLLAAFAVQAKYGDYDESTYQPGMLASDDLLPQRVLDQYQMTPAMWEDKIKFWYAERRGMTSDEAEMDYLKIAQDLEMYGVNYFQIKNKKDSDLWIGVDARGIGVYDRDNRLLPKVAFPWSEIKNISFNDKRFTIKNVNKKEPHFVFYAPKPRINELILELCMGNHELYMRRRRPDSMEIQQMKEKAMEEKARKQMDRSRLAREKQLREEAVREKEEMERRFLQMQDEVRQTQEALARSEETAELLHEKMTVLDEEARLLTQKAAEAEAEVQRIKLTAIKTEEERMHMEQRAHDAEILAAAILEDSENRAKEAEQLKDELMKAKLSEKAAKGKLLELTQTMSHTDYSTSIPSYPVLASDLSPTLQYVESGAPLPDGDIFSGNLDQLSLEMEKERREYLSKSKTLQDQLKDLKSEIQVLKVEDRSSTLDRLHDESMQRGDSKYATLRKVTANSAKARVAFFEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JT48</accession>
    <name>A0ABM0JT48_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 137</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100887.1">
        <property type="nucleotide sequence ID" value="XM_005100830.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860580"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026680">
        <property type="entry name" value="CCDC137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100887.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39545" checksum="8F4AF8FE52813626" modified="2025-10-08" version="1">MGKIGKPQRSRKQKKIKAIDPFYHGDRKGVRSKDLNQTPKSLIQEIPKKLKRLGYIIDDAKNSGGRKKSKNKFLTPEQGSVKYDSKFGTPLGSKSPESKPAAISTPSQKPQKKKKQRTPKHSADMTKEPGKKGKKSKFKQEDVEEYIDNLKPNKPFVEPFQFKRRNDESQAKFMRRVDRETNVVLAKAKIDEQYDVDDEKKIGMMVKAKKSKLNEKKKQRLADKKKLKAEVLKEKKQEKLTGFNALQDKVEFGDVVHAPPVLTVRPKKAVDTMGVDKPGLRMPELKEAIIRNMAESANGVDVSLQRQRGQTVKRKALSSGQQVIADARRNEFIEAYRQLKVKKAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTT0</accession>
    <name>A0ABM0JTT0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Meiosis expressed gene 1 protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC101863517</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEIG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101314.1">
        <property type="nucleotide sequence ID" value="XM_005101257.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101315.1">
        <property type="nucleotide sequence ID" value="XM_005101258.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101316.1">
        <property type="nucleotide sequence ID" value="XM_005101259.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826398.1">
        <property type="nucleotide sequence ID" value="XM_035970505.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863517"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020186">
        <property type="entry name" value="Meiosis-expressed_gene_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17008:SF1">
        <property type="entry name" value="MEIOSIS EXPRESSED GENE 1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17008">
        <property type="entry name" value="MEIOSIS-EXPRESSED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15163">
        <property type="entry name" value="Meiosis_expr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005101316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826398.1"/>
        </source>
    </evidence>
    <sequence length="93" mass="11240" checksum="69252BECDDBACB49" modified="2025-10-08" version="1">MAAAVSMPSVSQPKSMKRPTHWSEEVEEAYRFQLAGYRDEIEYREVQRTDHIDRWPHNGFVKKLVRRDGCFYYYNKTRECPDKQINKTKLYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUG9</accession>
    <name>A0ABM0JUG9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Chromosome transmission fidelity protein 8 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC101851275</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101776.1">
        <property type="nucleotide sequence ID" value="XM_005101719.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101777.1">
        <property type="nucleotide sequence ID" value="XM_005101720.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939928.1">
        <property type="nucleotide sequence ID" value="XM_013084474.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851275"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005101776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005101777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012939928.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15562" checksum="06C41FA8C738117F" modified="2025-10-08" version="1">MVQILVKLPGDETECKEWAIVELQGDLETRHPVPLSGKFIGDLHFAHKDAPVLIIGHHILHGKVMSLEKPFAVITKASNSETADGSEVTPMEADHADQALAPTSGSEDNPSQPSYHVKAIIRKKVLFKTRPKPIIAHVPKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUV4</accession>
    <name>A0ABM0JUV4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101856671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102053.3">
        <property type="nucleotide sequence ID" value="XM_005101996.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856671"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="159"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005102053.3"/>
        </source>
    </evidence>
    <sequence length="295" mass="32632" checksum="B4CFCB499DB6D875" modified="2025-10-08" version="1">MSEEEQVVAAGEIPVPHSAPLPFGLSDGKEIIVDGVAGHGEGFSINLCDGPDLNSQTAFHFNPRFNQNEVVRTHNAGGWGAEEKQGAFPFFRGSGYQVKIVVKDHAYQVFVNNSFFCDFNHRVPKEMVRYVFVTGDTSLSRVSFADQYAPVINNPPVPFTTAIPGGMYPGRMIFISGVPNFGADRFSVNLVCGGDFDACDVALHMDNRLAYGNGNTVVRTHKQGGNWGAEESFQNFFPFSPNAQFEIMILAEPSGYKIAVNNQHFCEFAHRIQPVQRADHVHVRGDVRLTQVRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUX0</accession>
    <name>A0ABM0JUX0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864696</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102087.2">
        <property type="nucleotide sequence ID" value="XM_005102030.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864696"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046724896" evidence="1">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102087.2"/>
        </source>
    </evidence>
    <sequence length="133" mass="14861" checksum="6C470B3D70C43C8F" modified="2025-10-08" version="1">METADGLYLLATLLLWVAECDMYARYLERPVSPWIPREHGLRCSVWNQSGCAEGECCIKEVISFQDLDKDLQVGTKCQPLLAVGELCLRQSEGYLCDCAKGLRCDFRNNETYGHCAFDDGSQESPERKGTAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVQ4</accession>
    <name>A0ABM0JVQ4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101849625</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102642.1">
        <property type="nucleotide sequence ID" value="XM_005102585.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849625"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF191">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045709768" description="Sodium/hydrogen exchanger" evidence="14">
        <location>
            <begin position="20"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="524"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="15">
        <location>
            <begin position="155"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005102642.1"/>
        </source>
    </evidence>
    <sequence length="683" mass="75191" checksum="975084A1EB21E48D" modified="2025-10-08" version="1">MSQCSRLLFVAFIFLWSNALIGHSAVVEAEAESQDEQALNVETDNLQSRSRPIRNYYGRMRKQAGDNANDHIVTTPAPVVESTQNISSGNATADVNATRSETGGGAGEEEQKKVPPTEEPEEEKEGGLPAKGAAEEEHHSSLTIFFILLVVAISILVVHLLIQTKFHYLPDSIAIVLIGALIGLILKLSKFGNWKNEEAFPPTVFFIVLLPPIIFEGGYNLHKGNFFHNIGSILVFAVFGTVISAVIVGGGVYLLGQAEVAYKLDLVESFAFGSLISAVDPVATLAIFQALDVDPILYMLVFGESMLNDAVSIVLTTTMLEFASPTAVVTSGTAAFFQALSRFCLMFFASAAIGVAFGLVSAMLTKFIDLHKTPSLEVGIVFCFSYLPYALAEGIHLSGIMAILFCGIVMSHYTHLNLSPVSQITVQQTFRTIAFIAETCVFAYLGLAIFSFKVNVKPAFTIWSIILILLGRAFNIFPLSFLMNFFREHKITRKNQFIMWFSGLRGAVAFALSLHLEIEAEKHFVLVTTTLILVLFTIVFLGGSTMPLLKFLQSSDKKYKKRKKSEGQVSMSKTKEMGDAIDSEHLSELTEEDETHIVRPHLKGFLKLDARYLIPFFTKRFTQQEVREGKSQVDLLTSQWQMEVRAAPSESDEENIEMETSLIPQASSGGLLHNGSNGSNTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVZ5</accession>
    <name>A0ABM0JVZ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Autocrine proliferation repressor protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102804.2">
        <property type="nucleotide sequence ID" value="XM_005102747.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845253"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009199">
        <property type="entry name" value="PhoPQ-act_pathogen-rel_PqaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31497">
        <property type="entry name" value="AUTOCRINE PROLIFERATION REPRESSOR PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31497:SF0">
        <property type="entry name" value="AUTOCRINE PROLIFERATION REPRESSOR PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10142">
        <property type="entry name" value="PhoPQ_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014728">
        <property type="entry name" value="PqaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046018088" evidence="1">
        <location>
            <begin position="28"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102804.2"/>
        </source>
    </evidence>
    <sequence length="502" mass="57047" checksum="F4DC2385F7A6CADD" modified="2025-10-08" version="1">MTSQISWPQTWLLVGVTVLYFLSAASARESNMRVDYGPWQSTPLDDYVRAPDPHYSFSFLKTISGPGFTLHILNMTSQKWLTEEVTVKPIWWHYLTIIIPDVINYNDTGFVWIDQGSNTDGIPSLEDPFVELVTAISVGSKTVGATVKQIPNQPTVFLKDPERKERKEDAIIAWTWKQFINNSSFPDILLRLPMTKAVVRAMDTVTTYVKKVKNYNIGKFMVAGASKRGWTTWTTAAVDKRVIAMAPVVMDLLNFQKSLHHHYRALGGWTFAFKDYYALNFTEDLDNPNITRMRAIIDPLTYNDRYSMPKLIVSASGDEFFMLDDSHYYYDVLQGPKFLKITPNAEHSLIGHEMDVMFALRSFYLSVLTSAPFPAFNWTRTQTTTGGKITVYTSQEPTAVSVYYATTLSDGRRDFRLLVKGPDGNAFPHPVLWFKDKARRVSAHVYEAEVERPQDGWRAFFVQLNYPGRAGTSLELTTETCVVPDTFVFPDCRGLACRGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW03</accession>
    <name>A0ABM0JW03_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC101847594</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101847594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005102815.2">
        <property type="nucleotide sequence ID" value="XM_005102758.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847594"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046764473" evidence="11">
        <location>
            <begin position="31"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="721"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="420"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005102815.2"/>
        </source>
    </evidence>
    <sequence length="763" mass="87255" checksum="68801DE5FF863E0E" modified="2025-10-08" version="1">MEKQNKTKMSSILRIFFLILGASTCSQSLASDHAPRTDEYPCDVTSDYVRGGKYVDCAARGLTSLEPNWFPETATTLSLDHNMLHNLVSGCFIHLSELQVLTISDSQVTTIHEDALRGLGKLKELNLENNKIYTSRLPSTIFSHIPYLENLYLKGNTWENEGTLEYPFSSSVPFSDLSHLTRLSIDEASEIIYFGQPFSKLKNLTYLYVYCPHYVVKGSNRSFEGLRNVALRELVLGGTGQEGHFETGILANVQNLDILRIHHVAIGNQNIMKCLWPFENKRMVLIDISHVFLRHHRATPTGTCNDGLMTKESLKHLSNICLSQLIWDNSKVVGIEPMALSAKPNLRRCLRSLQFTRNLMGEMDPWRSFYLELIRFESIEEIQYAGYEWCGPGYDFKFRNDHNVRKSGYETIHSFNTKSTSTAQTHALPHYSNSKNGNEREKLTTPSENSSSYETPSIRIPRESERTRFVLRFPKHLQSFIIVGFSGYFELSAWHIRDAQNVKEIRFVSCHWIEWSGPVSGLENVTLLDFTRSHVTSRPNFVPLQHFPNLETLVLNAMRESDFIDQLLKESWLQKTSRLQHIDLRDNHLHKLPRYVFSSNLIMNAVRLSGNRLTSLGFDLSPTPSLSVLDLRKNVISSLDLAARTALDTHAQRKPDFSLLLEGNPVYCMCSRIPFLVWLHTTWVRLDMSGNYSCIDDRGQDRWTADLVTTKALWRRCVGKMALLVSLCLALSLIVGFLAVYMWRRFRTAVGAFFLNILAPGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXC6</accession>
    <name>A0ABM0JXC6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein C10orf67, mitochondrial isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103756.1">
        <property type="nucleotide sequence ID" value="XM_005103699.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850494"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040119">
        <property type="entry name" value="C10orf67-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031651">
        <property type="entry name" value="DUF4709"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22382">
        <property type="entry name" value="RIKEN CDNA 4921504E06 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22382:SF7">
        <property type="entry name" value="RIKEN CDNA 4921504E06 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15821">
        <property type="entry name" value="DUF4709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4709" evidence="3">
        <location>
            <begin position="50"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005103756.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="67927" checksum="A90F429BD0532665" modified="2025-10-08" version="1">MADSPALGTEDGRESESPNDQHAYHKAEEDLQDHILAIYGDSSANNDMFRPALADNAKIGFFSLDSASQTEVTEIVDLKEMTEVLQILLQDVANLRRDINFTKHVMQADHDSKLQEKSLELYCRINERVVELEKMHQDRVNSLRKAFRQQLADAIARLSVHFSKNLQTKIVRERTKQKSDLADKEEKFKEMQATILRNEGVIQMLKTQLQQQQMKQQEEDDERFMERRFVMDESSSNKSKSSRASGSPVVPRVDSALQDQLNTAQEELEEATQKLEKSDKKISRLEEALDIKDEEILTLHKEMDAMKEQQERSEIMVEQLKHEHNELMEAAAQEKETTKKMADDLLGHQKEEMKRMMDEQLRLAKEEAVEKAKEEAQKASTAEQSKMKQMKSQLADLEKKLAKEKEKSSSATQDSISSKTLKESEDKLKTEILRLQAEVEKAHRTWEKKFAILQQSMHALKDESYLRQTLQRQAAQLHHAAVSYSTDMPSGVLPTKAPASSPSKKPLPEIRRGSKTGNQAQERDYISYTVSAPSGRGTAMFSADENQIMSDNELDLLPPEMEPLPEQPSRKGKDCGDQSRPSTQPHVVVLPTVEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXD6</accession>
    <name>A0ABM0JXD6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103775.1">
        <property type="nucleotide sequence ID" value="XM_005103718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855202"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027914">
        <property type="entry name" value="DUF4456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14644">
        <property type="entry name" value="DUF4456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4456" evidence="1">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103775.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13137" checksum="3FC6CDEEAA16B48B" modified="2025-10-08" version="1">MIFLSHRHRRISKPAKFDKKYMVFGEKPEEGETEAEEKHFLAMITRTLRDALDGLLTTAEVFYRQKGAHAVTRPQALQETFEQFADIITHKMQSYYQQADQYHNQCLQAVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXU9</accession>
    <name>A0ABM0JXU9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101850023</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104086.1">
        <property type="nucleotide sequence ID" value="XM_005104029.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850023"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005104086.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="50133" checksum="2AEE10631E3BCA7B" modified="2025-10-08" version="1">MASGLVLPTFHNAHHPSLTTTPQPGLGPLSRPPDVRPKERSVSRQERRTTSSLTSLNPESSTLNSSVERAPSVHLRRALREHKAVLDSVSVDESYLTSASVRAVEINLREYALPGERQLIVSAVRACAVRGRNYPKAAELLSCIIDADFEEWNIVHEFADFCHGYGGVENVPFFRHWRAVQGQAQGQAQGEGQVQGQAQGESQVQWGGQKENETVREGLSGSRAAVSDVATRLQESAEQPVRAQADVTAPPAAGTADVSTAPASGPVKGHLTSPLRDTSPTATNTAPKFEPQNQTTQGLSSNTCCPTSVDVNEIKIELNSSAPATTEKGKKSETSERGKKVTEKDWDEGRIDEKRKGGEEEVVQKPEVNQGHSETEACNRNKRPQLTQSQRREQLLRVLERERRYLKDKVTCSVCNSRPVETTFLPCSHLVSCLGCAKKCKKCPQCGKKVLAEAKTFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYV1</accession>
    <name>A0ABM0JYV1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Katanin p60 ATPase-containing subunit A-like 2</fullName>
            <shortName evidence="8">Katanin p60 subunit A-like 2</shortName>
            <ecNumber evidence="8">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">p60 katanin-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101846903</name>
        <name evidence="8" type="synonym">KATNAL2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
            <location evidence="1 8">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Spindle</location>
        </subcellularLocation>
        <text evidence="8">Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_005104763.1">
        <property type="nucleotide sequence ID" value="XM_005104706.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846903"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03025">
        <property type="entry name" value="Katanin_p60_AL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027497">
        <property type="entry name" value="Katanin_p60_AL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF78">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="337"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="345"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005104763.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="66163" checksum="C95611F0FCF8C092" modified="2025-10-08" version="1">MTELSYQAIRTANQAREADEVRTDSRKKNLLILVLNYLNEEGYLDSASNLSRETNIDLRRYEVCDNIDLETILMEYESYYFVKFAKYPKITKKLSPQSGMAAGAADKRAQAKVSRTNSLHRPKFVRQNDSPKSASVKSNTPSLPRIPQNSRPPTPPQQQQQQQQQQQQARPASGKSRRNITSSTRKALSHPALNGTALTKDVGAANGSADSLSLHGMTVHGTNGAAEPPVPPTPKARQRFGQIIDIRSMINDATKMNAEEGCDPSGTDRILKPLGGYMGYNSEWRELAQVIQRDIYHQNPNVKWDDIIGLDEAKRLVKEAVVYPIKYPQLFQGILSPWKGLLLYGPPGTGKTLLAKAVATECGTTFFNISASSIVSKWRGDSEKLVRVLFELARFHAPSTIFLDELESLMSQRGSQGGGSEHEGSRRMKTELLVQMDGLSKTDDLVFLLAASNLPWELDHAMLRRLEKRILVDLPTYEARRAMFRFHLPPVVSSKEGGLELLSELDYDMLAVKTDSYSGSDIKLLCKEAAMRPVRKIFFALENHTEGEELHIHLDKIKTSDVLAALERTKPSAKTMKQKYVDWQREFESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0G0</accession>
    <name>A0ABM0K0G0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein regulatory complex protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IQ domain-containing protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101854519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRC9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105843.2">
        <property type="nucleotide sequence ID" value="XM_005105786.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854519"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23766">
        <property type="entry name" value="IQCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042618">
        <property type="entry name" value="IQCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005105843.2"/>
        </source>
    </evidence>
    <sequence length="406" mass="47844" checksum="478C3903A73A4D65" modified="2025-10-08" version="1">MPGDMVKANEDYSSDTEEFLPNFDPTSVPLIEAVNLAVVFEDFSDQLDILGRSIVGPEIELRSKPSVDLDRELHRPVLDLHDKTNAPKDGSEPRYLLKQHYEMAIPRRIRQGYQGPATNFQRRLSDAIRESYLNTLTTNGKLQVDRGFLQKTVQDLMIDIIQKSSFECLVDTIETEKAKKEGMRNLAEKSVEDTRMIKQHKREIKLVRKEKVTESRRMDRFIWSLEDATQELLIRTKMEALYVTKTGAMITTRSTKICKKREKDFTNQLEDANLAMDNEYQVHQSMMEAIRSRHEQMQIKLDYWMDKYEVDKENLQNELDTLKANRAKDLELMAWLKHTIYNYNQICQDHRRIRAIQESRTKRSELENKKSIKIQAWWRGTMVRRKLGPFKPKKEKKEKKSGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K194</accession>
    <name>A0ABM0K194_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA-splicing endonuclease subunit Sen54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101862970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106386.1">
        <property type="nucleotide sequence ID" value="XM_005106329.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862970"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005106386.1"/>
        </source>
    </evidence>
    <sequence length="603" mass="68097" checksum="398422FE67BB2C0A" modified="2025-10-08" version="1">MAAKSFYDLTKDAALSAKSLFKYRVKRDNTVPSKGGQKNFEPDGTWMESKALEAFLQERTSVLGEPRVEKLKNLVHGVWDDSKNLVNVDKPGKFWSHMGFTDKRRNWLYPEEALFLMEINALEVSQNGIPMSIQEAYDLFLDDEMGLTEYQVFSHLRRLGYVVVRHEEQPLVTDYERQINLDKYLDKRTLKARKKKGGRPQPDKPGPSGVCDPQISSSQERLDEAEESFDKSGHSENSAAVVKDDSVESVGQSGETMANNSAKQIAEGQKRLRSESEELESGQADGVSDAKKLRSDDPDVSDVSSSKGDGDKTLSENSQGSSSPSGSVREFYSEAWLDCFKQKSRTDGTGEEIQDNKKTCLEQTSFQDNSVKFPDLAGKRVLSLVLPEKKLLPDNIHISEDTDDMLFFDVDDYRLKNPVEPLARQAQHEEDRERRLGALSFSFAEWTQRRPVVKSHSWADHRRKIADRMKELSNSTPVSHLWQGDITPLVNPCDAWSSESILEKLNIVKPADDKELKVSDDVIEHSHLSFDVHLPDSRFKKSMPGRPDHRVLVSKSRNSRPPELCQLQILSQADGVAVHWAVVDCGEIAFYVFDTKRTLGLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1W1</accession>
    <name>A0ABM0K1W1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101854664 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106781.1">
        <property type="nucleotide sequence ID" value="XM_005106724.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854664"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038817">
        <property type="entry name" value="CCDC192"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38580">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38580:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106781.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="58298" checksum="55C5FA76CE3A7EBB" modified="2025-10-08" version="1">MGSGASNQVRSDGVDDVSSIRNDLDLDCKNSGKIRPSSSTSLVSQKGFKKGRVDSSRVDKGSLNKRTTKPGEDSQSSVKTKSSPKTLTPVHSVSMTGTSNTSPVTPLNSTNSVVHPSVEKKGSALSEGQLTEKIKHLELELAKSESQRLDIQDQVQILEEKLKSAGSQSRLTDEATDLSETIHAKDQYIVKLEKDLKTLQTESTTMRLKLKRRIKALTNQLHEVRQEASINQMELKSEIAQCKEKLKSTGGQTSGTSTEESFKQDGSHSPSHSKVIVELSNQLSEQSERISTLETQVKEKDAFIQKLQAANGKPSRTSQVAFSKTIAVSNSNVKSSPNSEDVSFDRLHSSRGLRNGQTSTAATRESPLLVDDDDFNPEPSSRPQNSRMSTALSDSDSDWGADDVPALTRSAPARVRVKSAHMSQAKQSVTKETNALQGDDDSIMQYLHNSDIPARDSSTSESRTRPHKKSALRNHLEKRKNENQMSSLMGPSIAFANPGHELPSDTSCEPTPRYKDPSRLPGFSKLTVVQASNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2C6</accession>
    <name>A0ABM0K2C6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101847212</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107098.1">
        <property type="nucleotide sequence ID" value="XM_005107041.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847212"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047357062" evidence="1">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107098.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23804" checksum="C3E1B9E0599D16E2" modified="2025-10-08" version="1">MKFAVFLLLLSLAFAGCSAGRRWGMRGGGGRWPCRGFFCRFWGLSRRLPAPWRPSLPVCSGKGTLGERFALNLGINDADNDTFVSGPEIYNDFKNNYDTNNDGCVTEAEWTQRWERGLRFSKAYAVNRFAALASDNVTCPITYESFENSTDMQMPVGIFLSANLQTLVETCQSDNSRLISNCDCLQLLGACVNDAKLSEDSVCKAYVVQPVIATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2M4</accession>
    <name>A0ABM0K2M4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101860999</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107325.1">
        <property type="nucleotide sequence ID" value="XM_005107268.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860999"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107325.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="57842" checksum="E6BA420428B76C58" modified="2025-10-08" version="1">MLSAKVGPNFPGGGQLILEAASIPAKRLAQDGETFPRCVRSQREESNHSDKKLRNVCSPAELLDQDGGKPQGSSHECPPVTDSAESLEASTTAACAGDKISSLYNSEVTFSDSVPQKTTPKNGASDTDRNYALIPSQVPSDPVSLGGYNDVIMETAPSQGRNPEVLGVARDETCGVSHNVSSFGVENCKARTTADCEQTAHAKGRNNKSLYQTTLARGVPGYHEAEMSFRGEADLQRHLIDCDKHPGHEMFTPISSFGVQNLPEGYQDPDIVAYIRAQADLTVRVVSRYTSPDRPDNYAFSGNKGGTILRTGTGFIQYVYKCEGRTDKPCPCPECKKSDSPRAQWAKIKIRTATHVVFDDVEAKNSVAELFFDNHEDRRNGKVKTVFGDNVRFGAIQGDWCDMRCVTHDLELCDFIKDAWGRWRWLESKVNEKFRGDEHQLAVVVSHPHGCNKQVSVGRWAERVVVGGSKGWENSVYSYDTPTCPGSSGAPVWLLGKVKWGGFFGRHPHSGRPLEGLNLSATGWDKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K350</accession>
    <name>A0ABM0K350_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fanconi anemia group D2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107672.1">
        <property type="nucleotide sequence ID" value="XM_005107615.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862679"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11721">
        <property type="entry name" value="FANCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="802"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1370"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="849"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1382"/>
            <end position="1413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005107672.1"/>
        </source>
    </evidence>
    <sequence length="1427" mass="159278" checksum="CD5C7174059DB3DE" modified="2025-10-08" version="1">MASRKRRQSLVPSDLSNIAKKSKAKDDSYRKDNLLCELTKKAGLTLKNGKQPSVLDVSKAVFQKQLGLLLKNHSGDLLEDVETFLEEFGEYIDDQQRFHKSLQPCTVSDDSESTSGTVADSVLRLFLGVDVIQSPLMTLLLEKLQEFVGEEEDFIFHLGQKVYVPRLVLSQFRFLDRIVDGKELTKKLMEILGSSCLDVQKEIIACLPDIVEDSEHGEVAKKLRDELMSNKELTCPVIDALTYLSIPQDLVTEIRNSVLDMLKSFSICDLPIVVNFLLESITANDAQEVVTEIRSKVDFTSSSKLPAEELERVRTNIKLTVDALKGRMQFQRFVAEAWIKVIGAAKDSKVLDVFVLLILHWMNHKKAVESLVRNRIRAGLFTDFLLTKAFSSYSQVVREYFPSLQCLAQALLRSPEIVIGYCGSSVYSLAFTTFDAYCQQEIVGSLVTHIGSGFTGEIEAALDILADLVKKQPQVMARYAVFVKGVLDYLDHNNLTVGQIRKLYLLLAQLAYQNKAADGSYLQDDLHIIIRKQLTSTNSRYKRMGVTGAISVVHALASDTSDSEEELPADSYKQVIELLELVHKSGRRDPEMTALFLDSLATTIDTENLYSNVENWVAGNMVEAFEENYVMDVDGDDTELKEACPVTIESTYDLNKSESTIVINLVDLAQNLYDRTARRHLEADVSALCLCPLFHLVAVCTKKQSKGDLEAIDALLGCPVYMVEKTVSEKMATMSRKEKDIVCASVFLCINWFREIINSFASMSSAEVKGKVMMRLKHVCELTTILEKCLLQHPSFQPPPASFDLENSFSKTDASTSSAKPSAGGAEKKKGKKGGGKGKKGKENLEVSGASQLDKTNTQGSQALQKGSEEDSSDKEDQTMNMSVYRQYFRELDISVFTILKAGLVTRAALDSEMNTKATEQLQIGLPELQFLLEDLSLKLSHALVATATKRRSFLKTKSNKTVGFSSLDTYSPAEVAERAVKLLPCLLDHLEEACTFFQTLVAENDGVEDGPGRFTPEALAVSACYHLTLQCLLSLFSWNGFASDTHKPLLKEALLIVFRRMRASQDQSSFVSQQDSLSCTFQYLSNFVETIPTLEAAVTLLKLLAGLAERAGSEQMNVKLTKQAKAFLKREWRGADGERLKGAKHNELLLVVVKTYIVYCSEPLDALEEITTKGLAELANEDKDGCAEEFVSLNRHSFSTFYKVVLTELISHIKQIPALKKNDSEQVKEDRLLSWMMAVKVLHVAVSLIKVFSARGNLSAALKFGRQFVEIFLRLGMPLLDVTFRRHHEEVEKLLRSLQQSTRMLHHMCGHSKINKDVALINQVPMLKRSLEAFVYRVKAMLTLNNCQDAFWMGNLKNRTLKGEEILTQQSSIASSGETTANEDADENEEENQGDEDEDGDSEVELEAEVPEQETNADGGSYSEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3N2</accession>
    <name>A0ABM0K3N2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">NAD-dependent protein deacetylase Sirt6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101862375</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108006.1">
        <property type="nucleotide sequence ID" value="XM_005107949.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108007.1">
        <property type="nucleotide sequence ID" value="XM_005107950.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862375"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="105"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005108006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005108007.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="43449" checksum="BA8485BFC5E8963D" modified="2025-10-08" version="1">MESGAASSTSAGTCCLKCCIQNPPSRMIATNGSRVEVRAFEAKGKKNLVVEWKAGGEAIFHRDCWNALVHASQRAPGTATDIELTDLERSMIKESKKTAEYHDSHAGVAEQAARVARILKDSSYCISFTGAGISTAAGIGDFRGKDGKWTEREKKKNYGSQATKAKGRGFVIEELRPTYTHEALVKLTEMGILKYLISQNTDGLHRLSGIPAENMSELHGNSFIEKCESCDARYERTFACRQNKVPAPPLPCPKCKINHRTGRKCERKGCDSYLMNTIINFGDYLESDVLRSAEHHAKRADAVLVLGSTLRVSPANSLVAMGVEPHRIIICNRQTTPYDDDCGNGARVFGDCDRLMREVMRCLLPLPELTTWEKEREQRLVEYSLRRTLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4I3</accession>
    <name>A0ABM0K4I3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005108564.2">
        <property type="nucleotide sequence ID" value="XM_005108507.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854287"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108564.2"/>
        </source>
    </evidence>
    <sequence length="505" mass="56384" checksum="3FB23C0E782CA145" modified="2025-10-08" version="1">MYRIIKNNFNRSSVRLRLSRVCATYKMLSLCCVLAVLVVQAYAAPEEDLVTSLPGLGWKPNFKQYSGYLDAARSRHLHYWFVESSSNPKTDPVVLWMNGGPGCSSLHGMLTEHGPFRIQDDGKTLGPNPFAWNQVANMIYLEAPAGVGFSYSDDGNYTTDDDEVAMNNHLALKAFFTKFPEYKSHDFYISGESYGGIYVPTLASVVLDDPAINLKGFVVGNGLSDDDLNDNSIVYFAYYHGLIGESDWKFLLSYCCPGASSASVCDFAAGSRKSQQCLEKLSAVQQLVWASGLNVYNLYGECAGGALDRRFYYDKKADRFVTNQYLYPFNSMLKTDMSVMTMLKLASAKNVGVSPPCVNETSAKIYLNTPAVRTALHIAAKALTWDVCSGPVGAGYHRLYTTMRPQYEKALSRKMRILVYNGDVDMACNFLGDEWFVDQLDAKNPQQRKSWYYEAADGTKQVAGFYKAFDQITFVTVRGAGHMVPSDKPRPALKMFLSFIQRQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5G6</accession>
    <name>A0ABM0K5G6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urease accessory protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101859892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109185.3">
        <property type="nucleotide sequence ID" value="XM_005109128.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859892"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109185.3"/>
        </source>
    </evidence>
    <sequence length="226" mass="24533" checksum="19385BF12A7813A4" modified="2025-10-08" version="1">MEDKAMLLLLQLSDSAFPVGGFSHSCGLEALLQSNGKQRTDKNFLQSAFVSALENAGSFGVPFVQGAYQAGLVTQDLKSLDRLCQASSPNHIACRASTRQGQSFREVCSFVCTDLDPGVTSALSELPHCHVPVVHGALFSALGFDLDTTLTAFLFGVVRNVVAAAVRLDAVGPMEAQRMQKKLQDMIPDVILRNKWRSADDASVTFPVLDILQNTQDTLFCKLFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5L9</accession>
    <name>A0ABM0K5L9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial coenzyme A transporter SLC25A42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101861077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109276.1">
        <property type="nucleotide sequence ID" value="XM_005109219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861077"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="55"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="150"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005109276.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31259" checksum="3448F5916507C99A" modified="2025-10-08" version="1">MPVAAVVRGGGGAGKAGPAQTLAEGAEEGAEPHDQEEEHYHQEEHKVNEKVAAHHKVLTSLIAGAMAGALAKTVIAPLDRTKINFQIANKPFSAREAARFLYDTVRNSGVLSLWRGNSATLVRIVPYAAIQYAAHEQYKLMLNFRNKKHLPPHLRFLAGSLAGVTSVAFTYPLDLCRARMAVTPKAFYNHIGEVFMRMIREEGFRSIYRGFTPTILGSIPYSGFSFFTYESLKKVHAETHSGRDPNPLERMCFGAVAGMVGQSASYPLDIVRRRMQTADLVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K643</accession>
    <name>A0ABM0K643_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Placenta-specific gene 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109623.2">
        <property type="nucleotide sequence ID" value="XM_005109566.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861913"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005109623.2"/>
        </source>
    </evidence>
    <sequence length="133" mass="14424" checksum="DDE65840C37C1CD4" modified="2025-10-08" version="1">MAHQQQPVGFAPAPAGNTTVIVNQPMSDKSQVRDWGTGVFSCFDDMKICLCGWCCPLCLGWNVATDLGETGIIVCCVPSWLTVVRTKLRTQQKIQGDVCNDCMMSECCGICVLCQVAREIKTCKANGTLNNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6R1</accession>
    <name>A0ABM0K6R1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101862455</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101862455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005110049.2">
        <property type="nucleotide sequence ID" value="XM_005109992.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862455"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="292"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="426"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="787"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="816"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="933"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005110049.2"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115239" checksum="C4DA5497066275AC" modified="2025-10-08" version="1">MIMASLFCDFLGQIPSKDYRKISQKSHSSRRVQMMEQEVVGEPAQTDTELDVSYLEQRKISCLPRCPETERSTVCGHPTVVALSYHKESDTNFRLLVPTSGNSKCQIGRHSSEKTQSGGMDLCGSDVQSRMFGGMRRGGRTYENCPSRFVSGDFAWRNIVISVLLLFTAPLASSQGCERPPFAVNVNETDPPGTVILSLNAPTGVSWTHSFPANKANLSDLLGFDFDPVTQSYQLVVKETIDIDLPEIRAKFGNSTNHVQLELTCRQDSSGESREVTVIIVREFNEYPPEFNQSSIVVSVEEAAPVNQEIISLLAWAFDRDYRSGSREISIFLLTNASVDPQINGFPFLEMFNALNGDVTVKEKLDYESLPADQKYIVVGLEVQDSDRQSGTATLTVEVMDSDDLGPVFFYPSCPTPCVPKYYFTVSPNYTGLISDVSPAPIQARDGDALGYDVNYYITNGPDGYEEFLRMDPATGEITIFREIQSVEEGVDRLVFIIEAREVSTQALATSTSLLISVERSGYRGVPAASTDDNDVIIVAIVLSVIIFIIVIVLVISICYFRQRYKKAIHPDGTQPIVRADDDSSRSDHGTVDSKTDTLPIQDRLRRMNLSEDEPMREEEEIVTWMPVTQHKDIVDLSDEDTLRWKKRNGAPPKSTALANRDSAYEEGDKKSSSEDSHRDRDYAPETVYAEVDSAPEPSESLGRPGHVYKNQLTGVPSHETGGDSGVEEADYATPRGDRARTQPPSVFLNRAFISDEETERRKANKKMSKDKRSNEKRGGKPGGFGSDPNNNNSSNNNRGSGSGSHTYGDNRAGRSGSDSKSNSSSDNSAGKFLNDDATTFHTSTTHDPEESEATEYCIPISERASYVGRPLPIPEDVEEGRLTSIQLRQQEESRPLPPPRPRIKKLSGLIIQDDTEDPYAKVEKRNRNKPLQQQSSDADQSAPNSSPDHSPRSLGLMTSIQAPARRKRPRRRSRSTQGRAAEEDVYDGTKDYEDLEMDSGFYTDSTKKRIKRSTRVPVMKPDPNDTRYWITVTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K770</accession>
    <name>A0ABM0K770_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101855448</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110359.2">
        <property type="nucleotide sequence ID" value="XM_005110302.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855448"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050831">
        <property type="entry name" value="CEA_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427:SF8">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="71"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="149"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="283"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005110359.2"/>
        </source>
    </evidence>
    <sequence length="404" mass="42643" checksum="566DA3D680E963A5" modified="2025-10-08" version="1">MTFELIDGVTGARLQTSSSGIFMVNATAVAKFYRCASLFNGIKKESRYNITVQGKDARAVGISGPSEWEVGVPATLKCETVSLNNTKISYQWLKKVLDSTPLPGETGETLTVTSPKAEFALYTCLVTTPGGTKDEASVEFSVVQDLSTPPYVSYDARPLNLGGRYTLECHSNFGETAVTYKWTKDGVVLPSTSNNYVIPSMAAKDAGKYSCSVTVNGKTLEAKNPFEVDTPGAKGKACKAALFTATCSGEEYTGNCLAGRCECSPGAELQQNGCALSVASSAPTVVSDVTTAMNLGGRYILICASTASVTGATYTWTKDGQTLPYTSATLEIPSMSLTDVGEYACRITVNGNTSPQAAAFSVRPRAVQPGQPVTDDPNPGTRVSVSLLVFTVTLLCGLVVRQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7G5</accession>
    <name>A0ABM0K7G5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HEAT repeat-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110564.1">
        <property type="nucleotide sequence ID" value="XM_005110507.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847537"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="384"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005110564.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="70351" checksum="6308E0DD395A8218" modified="2025-10-08" version="1">MGKSRTKRFSAIKHNPTGLLQGTDLGLDLPDDQNENGSSQSCNDISSFVTNIVDKLQSASSEDRACGCQMLTRVESQPRAVEYLLQQNIVRIICPLFLDSSSEVQINALGAVRNICIHGNESVCSAVVASDVLTPLTALIKQYDNTWTARKESGKCGSSSDVLIQAVELFTILCENNAKAVTVFNKENLLMLLLPMLKVETYSYDLSCAVAQCLHVVSENNPDVTAVCQDHEVQSTLFHIACGTATEIDAILFRTLVTGIVLNFSEAAVSPYHKVIVKNLSDVLDIDYVPVLKTALEKQQQAAENEMYSEEGVSSGVDKLLRAQGVCLELLANLCCTDDDEWEDMEMDCQGSEESSDDQALEEAGACQENSADGNMESLCLSTELHSSFMENNVLSKIMQKTLPVECPLMEQMRQFRWGKVVQTKLNELQSRGLLCLSNVVSALDAESLSTSPTPLSSIWTNVHKLAALSQSTHGSDEDHKWAVTSAMRAVIQRMAEFDVSNVGEVSTADLESMVNIGVSSKSRETQINVLRIISTIGCILSAQTPPHVLLTRIGFILCEVACNNEDVVVMAEALDSLFDVFKEDHTDAVVREIGLVDKLRSLQSSFKSKVSGQRKKLGENYGVVMMAKANLAGFIKYKTSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7K4</accession>
    <name>A0ABM0K7K4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein SON</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101845203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110637.2">
        <property type="nucleotide sequence ID" value="XM_005110580.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845203"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19870">
        <property type="entry name" value="DSRM_SON-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="812"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="879"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005110637.2"/>
        </source>
    </evidence>
    <sequence length="958" mass="105728" checksum="9BC55B7B54397F2C" modified="2025-10-08" version="1">MSEPNLSSIPLPSGDDAPQKSLSSAKKSAKEMLKEALKDHTGVQRKDSIQTMRKTSAVEAARQETTSSQNIVDKLFNDFITRKMSPASVCSSSSIAVERGKDSVNVGSMTSVDEISQLLDLEIKSIQSNSGSANVASRKLEEKQDNPETSASAKTIAHEVNQSSKIPNPKSSQSSGDQVNSQKLVSVNDVRSGSDNPKGSSSSNSTGETSDAVVAPQTVLPSCHVEEKKEKTQPVSESKRLETPTADQGDKSCGKSLSMLPLPLAKKAAKPKLLDLKLSQQSLSLLKEKETASSESKQWEEGEVVSSNSEDSDRNDTNSDGDGELPSDAGSVNSSTEEKKAHSSKHKKKHKHKKKKKKKSTKSKERSRGERRLDKSRDSAEKSSRLSSSEVTGTVFSDSLSDKESKDTRESGERKRKRKSSSEVGKEGNKSDSCRSHEDRQKETTPQKQRTDGKRTLSRDEFEDEKKKEKKRRKKSRSRSRSPKRSKHSSSRSKSSSKTSGTRNDDYDQWDAYKYKEDSRKWKTGHSDRTKDGQRGREDRDRDLRVRIDKAKLRKIAIANALQNMKTGHGPEISISTRAGGKSVEELTDFCKKISEKEKNKNDSDISESDEEEAEENEDDSLIHHPFKLKDNSSNIVLNIRNARQLPVLTPSEKQAQQAALRLTFPVSSGSHHRATESEWVPVQPKAAPSETVAPATPSKNTATVDKPVVEPPKSEPSIFPTAESKIDIGSIISERLQAVRKLQENPFDVQALSKMHQVQEQANKWASSQHLPGQFLGSTGAQVLSQEQLLGDRRHQAWAKKSQFLQAAPVNGGIGMFLLQKMGWKLGEGLGKNNEGNKEPLMLDIKIDRKGLQASTETQKGRNCQPQQPRAKDLSNKHPVSALMELCNKRRWGPPAFTVVSESGPDHKKNFLFKVKVNSVEYQPAVASSNKKSAKAQCAAVCLQEMGLLPRDVPLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7Q6</accession>
    <name>A0ABM0K7Q6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101854987</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005110759.2">
        <property type="nucleotide sequence ID" value="XM_005110702.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854987"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF2">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="6">
        <location>
            <begin position="374"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110759.2"/>
        </source>
    </evidence>
    <sequence length="611" mass="69358" checksum="AE2D07584E924061" modified="2025-10-08" version="1">MPSFDGIKNHAFSLGSNLFIPDEFEFPPLSTGINKSEYRSVMSPTFCALADEVEKNFCDLDFDIPEQIGGNTNASVPIENVQNVDSQTPNTDQPVGNLEQWCAEAIRRSDDSYDEMLSLSEDLSKCELYSYEMTLLGPIFSKLSISGPQNKAVNSGSPDQESGVVKQASLQHDSQSHTISHQVPTNSQYHTIGHQAPMHFTSQYHTISQQTPMQSRPQFHTNSQQAPMQSDSHRQTFCQSTPILPGSQCQSSQTFVPNSISSPTPLPSSTPLSTTYSTSLSLHPTHHQRSGSPSSSSPSLPQPKPARSAAQRLCNAEFKKPLPWCEFSESHLDDLTFMLMEAHKKHIGKDLNCVSPEEIAEKTEIYKKVCRLKERVFGKKTLHRYREEYYKILESTGVDIDGRKKWMELSVKVTDDILFKTVRFIKNVPGFRDLCKDDRVTLCRGSFLDCFVLASFRGCDFKNRIMIEDSNLAFNINEILGLFPDFDESIIFYLSVTKRIKKLNLTLEEIVLLKAICITSPDRDGLKERQKVEALYWQFLCCLLLSLHRRHPKPYSIYSQVITLLADLKTCVIIDHQLLEFFRMDITKLTRETDAPLYKEMLLYNHPATAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8K6</accession>
    <name>A0ABM0K8K6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribonucleases P/MRP protein subunit POP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005111375.1">
        <property type="nucleotide sequence ID" value="XM_005111318.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849807"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="122"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="514"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="709"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="742"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005111375.1"/>
        </source>
    </evidence>
    <sequence length="904" mass="100902" checksum="0F200ABD35C69700" modified="2025-10-08" version="1">MQTERKRKAGDSLLVSTAEKQPKMSPGRKKELQIVKDVNVQSYIQSRAVEVRAFTELVKNVGGNHTAFQKLPRHMRRRAMSHNIKRVPRRLHEVVKAELERTKAPAKRPSRRYRRRPSNLLSEYERRKRRIGWLETHIWHAKRFKMVEKWGYRLALHPCDKSVRACYRAVNMHCMMQDVSFESYIEVKGSREDILSGLSHITSQESGPTFASKMTSAGTRQGLVTLYSFDSYPRGCIGQVTYLWKGRKIADGESEDESLLWICCHPSFYSQAMSELRKCFPVSESQDGINGCENGNDGVPASPLVRVTSLKDQLVTLRLYGPGSNTVLAEVLRPASVVPAQSEGSAGTTGKVESERNNPAMWWKEYYSSEATRGDLDRQIEVWSRLKLCRSPAESPPHSVIAVTVRDPRVLLPPKRQKVASSNTGSVCAQLPSELFSPEVSSSPLWDVSVRQTVKSSKMAEKELNKLKGQQLIPGSELDLGDEESRIPVLLIQRPGIPSSPSLSSSSQAGYASGWDVVIPGGWAMAFWVAFVYRGARVGGLREAQSVWLQAGQLSAPGDFPDSRAGLSEINAELGDLKTRHERRPPAKRPNYTKLGMLFPFEYKAGELVKIWTAKVVENLPGVVLNSQYVLDGNNDNGVVVLRERKLLCLLDSVLANPSRFLKYGLTSMSKNNNKNNNKNCEQNESGNIYSQLSRYAAGKRLLDNFLSALVPVSFHMLLRGVPYFRGHVCLPSDDDLRTLDGDKSYGGPVENLHKDPGRSVRKAERKERLKLRRKKQKGRKTNAGSSVKGEETSGSHSSAFVVQSLDLLNRTAQETLKTQEVQSAPQQHEEKLDVLTQTGRPIIGFVRKGDFDLGRGQGSGVAFCSVAALLELVEQQKARTRSLVLVRNPSSLQFRFASLSIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8P6</accession>
    <name>A0ABM0K8P6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded DNA-binding protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111468.1">
        <property type="nucleotide sequence ID" value="XM_005111411.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850614"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111468.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19283" checksum="80AF5733C16D2BBA" modified="2025-10-08" version="1">MFGTIRRAVLQNPSRVFTALQAQCGRVMSGMSTDSVPFDEEAGDFKERRQERGLNRVQLIGRIGRDPEHRGTDEHPCIVFPLATNLSFRKASTGELMSKTDWHRICVFRPGLRDNVASRIAKGDRVMVEGSLSYQRYTDSDRPVNITSILADDIMILARRRNQEQEGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9P8</accession>
    <name>A0ABM0K9P8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N(6)-adenosine-methyltransferase non-catalytic subunit METTL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Methyltransferase-like protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101864274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112284.1">
        <property type="nucleotide sequence ID" value="XM_005112227.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864274"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005112284.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52657" checksum="1D043C5CA1F2BF55" modified="2025-10-08" version="1">MGDRLKEMRQRSQKRKELLAQVYGIENPNNLKSVLKTHDEIKVPEKKEKLSSFQGGTAASSSTTPVPSAFSPLDQKTTRERDSGQTAEDFEPDEIYTDSSAFLKGTQSANPHNDYCQHFVDTGERPQNFIRDVGLANRFEEYPKLRELIRLKDELIAKTSTPPMYLQADLETFDLRDLNCEFDVILVEPPLEEYQRTQGAVFDKYWDWDEIESLDIPSVAAQRSFLWIWCGNAEGLERGRACLKRWGFRRCEDICWIKTNIKNPGHNKNLEPNAILQRSKEHCLMGIKGTVKRSTDGDFIHANVDIDLIIEEEPQYGTKDKPVEIFHIIEHFCLGRRRLHLFGRDTTIRPGWLSVGPGLTSSNFDAEAYANFFDTNPEAHLTGCTEEVERLRPKSPTPKSKQSSSNERGARGGRGRGAASGGMGMGGPGRGGMRSGMSRGGPPGRGAPSGRFRGRGGFKPRGMRDDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAX6</accession>
    <name>A0ABM0KAX6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC101859687</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC101859687</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113198.1">
        <property type="nucleotide sequence ID" value="XM_005113141.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005113199.1">
        <property type="nucleotide sequence ID" value="XM_005113142.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829553.1">
        <property type="nucleotide sequence ID" value="XM_035973660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859687"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021139" evidence="2">
        <location>
            <begin position="26"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005113198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005113199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829553.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43407" checksum="E1FF758B37DECFD5" modified="2025-10-08" version="1">MRKHLCLYSAKLLWLLMLAGPMCESKVSNVFLNSYYHCGHDKTYEVNPNSGYLVMPDVSPDSRTHTFRDCEVTFHSARQTGNLCVSQEGSLSRIMDSNAELSVYDGYGDDKPKVFTLGYYPDEWAYREVCTNSPYLHFYIRRKDKTVNVNVRNMKLLFKVLDIESKDRTLYFDEQYCDGNYKLKKSWVNVLNRLPPSSTGEGREAKEICGFELDKEPRDGRRFCVVYVPLENFDCSSGWELSVSSKPRSLKRQFFVFSLSCSESRARKTQVWCGSNSTDSYSLIMQRKVKGDSVVEPARMFRLIVTDYDGSVESLRAKVEAELRKGRHESEGLGTVYIALIIALVVGGLVLLAAIVYKVRHKMPWYHAVHNPGSEKEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB31</accession>
    <name>A0ABM0KB31_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAP kinase-interacting serine/threonine-protein kinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101849990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005113317.1">
        <property type="nucleotide sequence ID" value="XM_005113260.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849990"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="97"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005113317.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="43372" checksum="14FBE03367248383" modified="2025-10-08" version="1">MSTSMCDQIETMRGRSQDSNTSKDDMLSILKTEEVCNDGVMHPSATNAASLDSVFSTSDSSTSFSSSGSFDSSSSELTGKQSRLNQITFANFCERYERTGQKLGSGSYGSVDTFRNRESGREYAVKVIKNCDNKSRKKVWNEIDICQRYSCDHIIKLVEFCEIGDMFFLIFDKMGGGDLRGMLESRDCLRLSETESSKVMNTLAKALQALHVDGVAHRDIKSENILCKNSGEVTPLVLGDLGLASDLASRCELSKGDTTKTTLTSPVGTPMYMAPEIVALMCDDSKPPYDTSCDMWSMGILLYEILFGVMPFQRGCDKDRGSMDFSCNDCKILMYQDILRGDYSFPVNVGEFYAHSAVDLIKRLLVVDPQARYSAAEVLQHPFLTEQNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUN1</accession>
    <name>A0ABM0ZUN1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin iota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934811.2">
        <property type="nucleotide sequence ID" value="XM_013079357.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850540"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012934811.2"/>
        </source>
    </evidence>
    <sequence length="142" mass="15238" checksum="0E7253F0DF09E3CA" modified="2025-10-08" version="1">MGVDDTTDIFNSNLQIIQVQDKDVHEDFEDIYDHNIAMLTLVSDVTLRASAQVVKLANLFEGGPGSTCTVTGNGIDEGGSKTTKLQVATLSTVGLLSCIITWYRRSEEFKVNKREVCAVSETATPCTGDNGGPLVCKRPLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV16</accession>
    <name>A0ABM0ZV16_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.4</ecNumber>
            <ecNumber evidence="4">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="4">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC101859606</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.4" evidence="4"/>
    <dbReference type="EC" id="6.2.1.5" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005089238.1">
        <property type="nucleotide sequence ID" value="XM_005089181.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005089239.1">
        <property type="nucleotide sequence ID" value="XM_005089182.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012935037.1">
        <property type="nucleotide sequence ID" value="XM_013079583.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859606"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="6">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005089238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012935037.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="33617" checksum="9523ACCC28A6152D" modified="2025-10-08" version="1">MAASSKVLARLPGLFRPAVRSVYTASRQNLMLDENTKVICQGFTGKQGTFHSQQALEYGTKLVGGVSPAKAGTEHLGLPVFASVKEAKDATGATASVVFVPPPFAAAAVMEAMDAEIPLVVCITEGIPQQDMVRVKHRLVRQSKTRLIGPNCPGIIKPGLCKIGIMPGHIHMPGKIGIVSRSGTLTYEAVHQTTLAGLGQSLCVGIGGDPFNGTNFIDCLEVFLNDPQTEGIVLIGEIGGSAEENAAEYLKQNNSGPNAKPVVSFIAGLTAPPGRRMGHAGAIIAGGKGGADEKIAALKSAGVDVTMSPAQLGTTIAAAMAKKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZW80</accession>
    <name>A0ABM0ZW80_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC106011271</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106011271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935815.1">
        <property type="nucleotide sequence ID" value="XM_013080361.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011271"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="44"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012935815.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41839" checksum="ADA5626FAFC31937" modified="2025-10-08" version="1">MDDVTVQTSPRPEPEPLLNMDQYGTALMIIAILTTVPSLFGLASNILNICVFSRMRLSHTVTISCFALSISDLGTVVALLMLNVNVVFIVLDLKTGIHIDVDPQTILMLTGDVMEVFLIISTLFTCQLAITRSMCVLLPLRFKEYFTPRKTIVILCLLTVPCFTHLAIYTQVEIIGIKIADNSTRAVLTFRNTYKLATLIFDVLRGPVIILGSEIIVTTCISFMIYSLRRNMTFWMKTKQAGHVNAPHTDIKHDSNAVGGSGLAGTLPKNTSGRKKSSMNATVAVREMQVIAQVTLIATIFVIFKLPIVALLILRYVDRNFILNGLYRKTLVVMSGVRVVFEALSASVNIFVYYRYNTKYRITLRQFLRLKAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWI8</accession>
    <name>A0ABM0ZWI8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protease serine 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106011325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935973.1">
        <property type="nucleotide sequence ID" value="XM_013080519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011325"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050850">
        <property type="entry name" value="Peptidase_S1_Elastase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24257">
        <property type="entry name" value="CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24257:SF0">
        <property type="entry name" value="CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045978467" evidence="7">
        <location>
            <begin position="31"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="158"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012935973.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33547" checksum="C7321172042FF1E6" modified="2025-10-08" version="1">MGPSGVLGGRLHVAVWVLALTATTSPTTDGFALLNGDTPDFGPMFNFSDFNKLEHQDSDIFAAEASEDDGSEFGPTFNISEWKQVLSQESNSFDAKENVMDDKSDATSEFGPTLVYRELFAVDDIPHTGDGPLVYRGPEARDENLTRGDDGIAPSPSIIGGINVPISLVPYTVALLVRSGGLYYQICGGVLMTRRKVLTAAHCVDQSRTYYVMMGVSDLRDSRNPYLQLIQVSRKYIHSSYRTYQDYDIAMLTLSSSARLNSRTWIVFPGYYLDTLPIKRCTVSGWGRTRTGEFFVGCCYTLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ55</accession>
    <name>A0ABM0ZZ55_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-type mannose receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937517.2">
        <property type="nucleotide sequence ID" value="XM_013082063.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855487"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046690256" evidence="3">
        <location>
            <begin position="25"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="37"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="189"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="336"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="485"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="626"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="772"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="924"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1219"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012937517.2"/>
        </source>
    </evidence>
    <sequence length="1237" mass="138517" checksum="FA7D1DFB249AA08A" modified="2025-10-08" version="1">MSPSLPSLVLAVFCSFVIFHSAQGACHSGWITVGNGTTAQCFKLFSGQKKTYNDAVNFCKQKGGYLATDTSLAIHNKIKPYMRNARNSGSKPEYFWLGLSDANKNVWTWSNGQPYGSWRWWWGGKEPTPNATKMDCVYMATNEPLMVWHVSTDCNTLKAVICQANQNAPRPTTPRPRVTCPRGWSLYAKAPTCIRLFTQGKPWVDARAFCQQQGGDLVKISDSGINGFVDGLVNKQKATYWIGLHDRHKENVFQWLDDDVKTPFTYWTPGEPNNSGGNENCAELVSDKQNHWNDGVCESRLRFICQAPTVQNTLPATSPATPPSKNCGAGWEDDPNSDSCYQINTELLSWLDARHACQSAGGDLATISNVQEQFYLSGRSLILDADFLWIGANDRGVETGWRWADGGPMGFINWAPHQPDNAHESDCVVMVTQSGRWDDLPCQDRYGYICEKKGFVTSPTPKPTTSPAHLPANKMWGCGQGWRGFRGSCYQMQYSAGGMSWDNARTICGTKYSSLVAITDGAENKFVLSLLPKSTNQYVWMGLNDVGMENSFVWNDGTPITYTNWSPHEPNNLGGEDCVAMYAKTGAWNDAKCAIKAKLSVCKKNKAVLNTAQRDIFKGCTKGIGYEAMCYSFVYQPAKTFAQAQAYCKSFGGNLATVNDRYVQSFLAAEIVPKLGVGYWIGMSMTAQTNWTYAWVTPFDVDFTAWDKSHTGNENNTCVAMQKKRPAGLWVNKNCNQAQSYICEYPRQGYTTPVPTTTTTARLLCPTGWFTVWNRCYKAFQMSPENMLTWTDARDYCASLWTGGALATIRGKTFEGWMLNHTLQNMQDIFWIGLSDRSTEGGYKWEDESPFSFSHWGTHQPDDAGGKEDCVTWNTAKNTWNDETCYVAHNFICQVPRGAVITTPRPVPTGKSSLQCGNSSWSEYNNNCYYISPSDGDDATKTWFEARIACMNIRGDLVSIGNDEENAFVTSLVSRHPLGTFWIGLNDLDQDTFKWSDGSPVSYISWMTNEPNDAYGSERCVRIGSGSLWGDQHCQEKRGYVCKKRPGDYTVPPMTPASTKGGCPLGYHSLPSLSKCFTIGGLKPSQRVNYTDAMSVCNLLNYKSRLASIHNPVEQKFITVLLANSGSRSPSWIGFNDRRFEDQFVWVDNSKVDYTAWGYKQPDENKNDKRWIARRDCVDMDMGVQNSGRWNDRRCSNKYSFVCETAKGEEKTQTASTHTHTHTHTHTHTHTHTYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A015</accession>
    <name>A0ABM1A015_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase MARCHF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Membrane-associated RING finger protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Membrane-associated RING-CH protein V</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase MARCHF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101859679</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012938060.1">
        <property type="nucleotide sequence ID" value="XM_013082606.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859194"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16701">
        <property type="entry name" value="RING_CH-C4HC3_MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="14">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012938060.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33459" checksum="3BEFEE1E1B7E7D97" modified="2025-10-08" version="1">MSYSRLQSDQDRRSCWVCFATEEDDRSAQWVRPCRCRGTAKWVHQTCLQRWVDEKQKGNSTVKVACPQCNTEYLILFPKLGPVVYVMDIIDRVIYKMCPFVAGGIFIGTVYWTMVTYGAVTVMQVLGHKEGLNVMEQADPLFLLIGLPTIPLMLVLGKMVRWEDYVLRLWRKHSSKLPLLNYLFPDEHSRMSRVPADTVTLTDPISATRVLCGALIMPTIATIVGKLMFGLVQSNFQRTLLGGIAFIAIKGVLKIYYKQQQYLRQANRVIKDYEEVGESSATATPTSEDGAATNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0N2</accession>
    <name>A0ABM1A0N2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101853002</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938426.1">
        <property type="nucleotide sequence ID" value="XM_013082972.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853002"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045309968" evidence="1">
        <location>
            <begin position="17"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938426.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="31522" checksum="5C0B917E4628BDCE" modified="2025-10-08" version="1">MKLAILCLAFAAVASGLYIPAEEKRDLHGTAVIIENVIKEIENALHPGNKRDLHTVAEVIENVIKEIENAIHPGNKRNLHDAAVIAENIIKEIENAIHPGNKRNLHDAAVIAENIIKEIENAIHPGNKRNLHDAAVIAENIIKEIENAIHPGNKRNLHDAAVIAENIIKEIENAIHPGNKRSLHDAAVIAENIIKEIENAIHPGNKRSLHDAAVIAENIIKEIENAIHPGNKRSLHDAAVIAENILKEIENAIHPGNKRGLFDFIKDKIQDVKDTLEGIANVDLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0Y2</accession>
    <name>A0ABM1A0Y2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101852855</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_005099498.1">
        <property type="nucleotide sequence ID" value="XM_005099441.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938595.1">
        <property type="nucleotide sequence ID" value="XM_013083141.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852855"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005099498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012938595.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43735" checksum="5BB70A64D840D090" modified="2025-10-08" version="1">METDSTETQGSLESGESSGASASSSEACGAIKPTCVIVLGMAGSGKTSFVQRLTAHLHMKKSLPYVINLDPAVIEVPFPANIDIRDTVNYKEVMKHYSLGPNGGIVTSLNLFATRFDQVMGFIDGRSKECKYVVLDTPGQIEVFTWSASGSIITEALASSFPTVVVYVMDTPRSSNPVTFMSNMLYACSILYKTKLPFIIVMNKTDIISHSFAQEWMSDFEAFQEALEHETSYVSNLTRSMSLVLDEFYSNIKSTGVSAATGEGLDDFLAQLDVAREEYEKDYRPMYEKMRREKEEKEEAEKQERKDNFRADRSSDQSKKDSLLSSVSSKVTIAPGDDEDSDDDFLGRGRAVDSDEDKDPEEKSFQRYLDARRQQLEKKVHISHPSQPPPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A161</accession>
    <name>A0ABM1A161_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101856901</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938724.2">
        <property type="nucleotide sequence ID" value="XM_013083270.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856901"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047157740" evidence="1">
        <location>
            <begin position="23"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938724.2"/>
        </source>
    </evidence>
    <sequence length="209" mass="22825" checksum="A2DF63C6ACA769B5" modified="2025-10-08" version="1">MALVLLPVAITIASLSVPALWARHCSQSESRVFYANAGHVTSFWDAVQTCSRLNGFLAEFPTPADDTTLTYVNKTAVAPYEPLVVGAVSFGSTSVFRWYTSGEIVEKIGDVDSAMNVSRSAGTEGEKKCFFLMGGRLGRGVCEGWEPQLVHALCQINLHEKKFLTGACTLCMCPGMSRPQCRKTVCGWPCAELIETTTCEYYPCRSNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A216</accession>
    <name>A0ABM1A216_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calmodulin-like protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939232.1">
        <property type="nucleotide sequence ID" value="XM_013083778.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012066"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939232.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17028" checksum="CD9F23EC96C1A5FB" modified="2025-10-08" version="1">MALYFTENQIDEFKECFFFHARKGHISTEADLSIIIRSLNFSVTKDEVGKYFTQAIAGDGKIDFASFLNIMHEHSQVERRQSELKAALVAQDRNKRGTVDATQLRHILTNMGEKLSAREVDALFREAGVQPSGQININGFVDAIMTPSPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2B7</accession>
    <name>A0ABM1A2B7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC101859791</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="RefSeq" id="XP_012939404.1">
        <property type="nucleotide sequence ID" value="XM_013083950.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939405.1">
        <property type="nucleotide sequence ID" value="XM_013083951.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859791"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012939404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012939405.1"/>
        </source>
    </evidence>
    <sequence length="734" mass="82210" checksum="701BAA3B9FF8D5EA" modified="2025-10-08" version="1">MAAQPNSQYLIPNETEVALLNCSEAFEGLSQRERLYSHHLAQASFKGGLIVLLQTSPESPGIFVLLQKLFRSQSPAEVSELAKSVGFSDEDVQAFFIYAAAFYCNMGNYKSFGDTKFVPAVERSKMELLVKASKAYTDDSAGLQQLWDKVKERMFSLGDRDKELGLAPKGTSTYYSANCDENDAKLVQPFLDEKKISPYNTRLVKTADECGETVYEVCLASAEHGAAVISGFPDDSVFGEHMYTPSGEKKAIKFKVTRGDYSPLMLMLSEELSNAEQYAANDNEKSMLKEYIKSFTTGSINAHKDGSRFWIKNKGPIVETYIGFIESYRDPYGVRGEFEGFVAVVNKAMSTKFAALVSGAEHLLAHLPWPAEFEKDKFLRPDFTSLDVLGFGGSGIPAGINIPNYDDIRQSEGFKNVSLGNVLTSGYKDSKITFLRDEDKELYSKYKISSFEVQVGLHELLGHGSGKLFVEEKDGSLNFDVDSVTYPDSTEKISKWYKPGETWDSKFSTIASTYEECRAECVGIYLCLLSDVLEIFGHTGDDADDIIYINWLNMVRAGLLALEFYSPDTSSWRQAHMNARFVILRVLLEAGEGLVKIEKFTGEDGKPDLRVVLNRAKITTIGKPAIGKFLCKLQVYKATADVEAGRQMYSYYSDVNDSAEPHFLSLRSIVLERKQPRKLFVQHHTYIEDGEVKLKSYECSASGLIESFVDRFPSADIDRVLLGLWEKDRVKPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A416</accession>
    <name>A0ABM1A416_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940384.1">
        <property type="nucleotide sequence ID" value="XM_013084930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012323"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="59"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940384.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29886" checksum="CD31904452D29317" modified="2025-10-08" version="1">MRGEMLSRIHDGHLGRERAKSSIWWPGLSSDIREVVSRCDHCQRKCPAQPSEPLNPTALPERPFQKVGVDLCNYEGHDYLVLKDYFSWYLEVGYLPDTTSETVVYKLKNIFARFGIPELLVTDNGPQFVSDCFHKFVKGLGCKHTTSSLHFPQSNGELERAVKEVKKALSLDDPFLALLIYRSTPVSPTGASPAELALGRRLRTTLPTLPSNLNQQVYDRAKIAARDAESKHKYKQAFDRGHGAQNLPELNPGQLVLQKLENDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4E7</accession>
    <name>A0ABM1A4E7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylcholine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940634.1">
        <property type="nucleotide sequence ID" value="XM_013085180.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852974"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047320462" evidence="1">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940634.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25629" checksum="2D0A173C5341C5FC" modified="2025-10-08" version="1">MARFILLCIALTFAGASSASRYNELYNWVSGKASPGFPQPDDSGPLDVDMRLTKLDIVGVDSANNLVTLIARRRVLWADRDLAFDEATYNVSCVYAAATNIWTPDSTFYNSAGQEQVLNREVIVFAGGELLEIARVKVSINCDVSGVNTYTGATCHLQLGSYGLGNELFHLREPKDNWTFHLESAFNGASPYELLSGDVSKSVEPYASGDPEQFYYDALTFTFSFRRKWGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6L3</accession>
    <name>A0ABM1A6L3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein REM 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941826.1">
        <property type="nucleotide sequence ID" value="XM_013086372.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854597"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012941826.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="35673" checksum="61AB7E83CAD5435B" modified="2025-10-08" version="1">MLEGLGIPHAGTSSSPLVIGNDDPGHLSAKDRLRMEPFDSSISVTGIFSGKTKANISTKQESSCQPREARTPEGPKSFTTTAKGVINAGDIVRKTSVNSLMSSGSAVPLEERQEAPLSAGAADVVIQGDEGVGKTALTRQFSSSEYMGTYNNATSTDGDMTETTIVPVLLDGEESVMEFIDGADAYQIDDVHVDAYIVVFSIVDRNSFVVASDLARQLRVNMGTDRAIILVGNKSDLVRKRQVNTEDARQVATTYDCKYTETSAALNHQVDELVAGTLAQIRHQLLPPVHELAPPPPMKTRSRTPSPVSFFHRLFKRNPKGSASCEGIFMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7Y0</accession>
    <name>A0ABM1A7Y0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ficolin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942560.1">
        <property type="nucleotide sequence ID" value="XM_013087106.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012883"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942560.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36429" checksum="95134A50ACF45A3B" modified="2025-10-08" version="1">MSAVDDVTARSVVECTSICSQTTDCSAVSWNEQTRTCFLHIHCPPDTTCSDSSSELVHFKKKVPCQNGGDFIPETKTCLCNDGWAGDECERYPYNCVEFYQREYGTRSGPVWLDPQHDVTKLTRTQCNRPGAKVITTIFRSDGRQPHNKTYEDFVSGYYINSKNYWMGLDNVRALNQQGFDEALYSVVFDNPGMGDFKWRYSGFQIGDPSSGYPISYTTANDASSQVPAATDFDLSLSNCFENISGVSFSAWDHETTGSDCAGRHGAGWWYPDDCHAPCRLLGLRRELFPDQGEEEYLTIPGLRLDNHTVEESMAWTYLFFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8E9</accession>
    <name>A0ABM1A8E9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942811.1">
        <property type="nucleotide sequence ID" value="XM_013087357.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847837"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF36">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942811.1"/>
        </source>
    </evidence>
    <sequence length="565" mass="64221" checksum="760050A01E02DFA3" modified="2025-10-08" version="1">MPGQMFDHIRDMYQAELYEDLKQLLCVVLSMIDGNAGGEAGEILSLPQKYQSLIYYGEALYQLGEYKKAESVFMRCLLLRKTLNKSKIKSVSSTELTLEVDVKYKIYQCLHKMKQNSEALSVLESINTKKRTSRVNLALAKLYLHEGRDRSAITCYKEVIREHPLALDALTGLLSLGMRGVDLMTYIMNSIPQVSCDWLNTWIKGHAHMAAKEYSSAISTFRTMEPRHGLKDNVLVLSYLGEGCFHAGHFAQALTQFRRIHTLDPLYLKNMDMFAYLLAKEKKLSDLHCLAQNLMSVSEQSVEPWVAMGYSSLHSPTLNKYKTIRAIYCAQKAYSLDNLCVQALVLKGAGLLDMKKSQQAMQHFQEAVRMAPSRFEAYQGLIDCCMSNRKMKEAYAWAMRACKTIGNNARTFTLVASVLAKDPNNIAKAKQYLNRAMTFDPNLLDPVYLMVEILIQEQEFAKGVELLRKMLENHSTTRLHQQLADCLANMNQHQEALDQYSISLSLDPNNVRAREASEIVEKHNEMGLESFIPDVDAEEMMNASDGEPDYSDMESTWSETEYSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A926</accession>
    <name>A0ABM1A926_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106013032</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106013032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943153.1">
        <property type="nucleotide sequence ID" value="XM_013087699.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013032"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012943153.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41011" checksum="CD4EBE92AD43454F" modified="2025-10-08" version="1">MQDDLAYRVPRHYKWDRMNQNRAARFKLNEFGTDRYNYYSFLDSLMGEIPGKDNYGANLTDDAFGLLNYDVGVTSKMSVLNTAMYHRWFKLGQKGAMGLTVNHRGYNDENMWVAMTNQPNVMPMTIKHCVSGHCSWATRRVSYALPLEIIYTTPLFNWNPYKLAFHSVIEFYHNANGNGQHDPADTAKNYVSVLDTKGVMKSVAPTGFRVITPDIQDVGKIRLRYPIFPVHAEGSTVGQELMALKEMVMKMGRYQYLYEETPMGQALPPDEDKTFHVRDSAKNPPGLHGHDFTLTSDEYKSLMAGNDTTVTTSFNLGHQHQMVIYYNTRNHNYYFKSCDGQPRCWDGHGSLLQLYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9V0</accession>
    <name>A0ABM1A9V0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ciliogenesis-associated TTC17-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101848238</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in primary ciliogenesis by modulating actin polymerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CATIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943597.1">
        <property type="nucleotide sequence ID" value="XM_013088143.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848238"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22973">
        <property type="entry name" value="DD_CATIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048777">
        <property type="entry name" value="CATIP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047501">
        <property type="entry name" value="DD_CATIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505:SF3">
        <property type="entry name" value="CILIOGENESIS-ASSOCIATED TTC17-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21772">
        <property type="entry name" value="CATIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliogenesis-associated TTC17-interacting protein N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012943597.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44217" checksum="6E43C03EBE7B3190" modified="2025-10-08" version="1">MSATTERSPSLFTTGASEQVAQPPASVEIPKSSPEAVSYMEELVPEEDFKYVMFDDNLVTVSDAGKELGEFTVTVEPTRYKGLECFLIHANSHGSIDGVPCGTSIVCHVSKCLETLEQQHHEYVKLDNCPLDRKTFLVRHSDGYTINRVITQGEDVQRTTKNIPVDQMKGFISEGSNLLLHRLLIEKPMDHDLQFISFDSDTNLCPAVYKKLDGRTQTVEDVELRVYGIERTIHSTFDLPTTWQSYFMNDGHLTNRVQVGSPVTMKLAKVPMRIERDEETPKPVFEKKDLNWEEDMQLHSKFLDRKEELKGDHATYMRHHPELRALLADFLQFLLLRKPEDVIAFAADYFSAFSTSMPDPSPYLASNAPTPFPASRKNTRIDDLRAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABD5</accession>
    <name>A0ABM1ABD5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein transport protein SEC31-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944455.1">
        <property type="nucleotide sequence ID" value="XM_013089001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013394"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944455.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38089" checksum="A89ED5B2BCEBBA99" modified="2025-10-08" version="1">MLSTELVKRQKGLGQALPSLDDQQEASLPEGLYPEMNPALQQQLMLLQLQQQQQALMALRNGARDRGMPPMEDLRAASMDPRLAMMMNGPPMQTPMPPSMMAPDMLRGAMPTDMRRMPGNDAPGVPEPFQDLRPMPPGQETGRPYRQRIRSFLEKLKAKVAERKAEASPEKRKGGDRARALRARMMMRLAAANGAPNPMMGPGPVMGQSPMMGPSVMGPYPAMGQNPLVQNPMMGRHPMMQNPMMGQHPMAQNPMMGQHPMAQNPMVGRHPMAQNPMMGPHPVPQNPMIGQNPMMQNPMMGPRPMTPRPPLQRPGMLPPMAQRTPGLPTSPSDPRSLNGQSRFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABF9</accession>
    <name>A0ABM1ABF9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862243</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944492.1">
        <property type="nucleotide sequence ID" value="XM_013089038.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862243"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046686003" evidence="1">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944492.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31010" checksum="AF647FAB6E0F9B23" modified="2025-10-08" version="1">MLRLAVLVCALCSSHALLFSTSGGLWNNLKVTWGLNPFSSSTFVGMPRTETQAISQGFKKISSCSTTGTFRGNRYVKGNDYAVVLLYDVKGYIAGIQASIPGNQTDGFPKHRSDKIFVKDGDRYTITAYFVDPSTICTTGRSAAQFSSHGTGTNLYIQKDENPEASTMIPHQETNVKKVSEWTEGKCFLTMGKHYWHSLTKDKNMDCNKMLPVFLLYNGGELNGFGWAMNTNLGSPRYEHPTKTSIPSFMHTVPTCLLNAQHLSTMHIYFTTHVELDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABS5</accession>
    <name>A0ABM1ABS5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox protein OTX-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101851156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944689.1">
        <property type="nucleotide sequence ID" value="XM_013089235.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851156"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF9">
        <property type="entry name" value="HOMEOBOX PROTEIN OTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012944689.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="25385" checksum="9A535A947F9068FA" modified="2025-10-08" version="1">MSSPQVWFKNRRAKCRQQAKAADQKKTSSSGTGSNNNNNSNSNNNNNSAGGGGGGGGGTGGQPGGNTTTPPPKKELKATPPPPASVSPVDYKPSVSSPMLHHAPGGPLPSNQATRRESQDVWNPANPMFQPMADIGMSSCMQRSPYGLPNGQPQYGQQAAYNSYHHYGSNMDAPYSLPNMQLPVMSSSAHQMGNVPSQHPYQMSSGYGSLPSANTLPRPNTQAHPEVGDYINKEYVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC28</accession>
    <name>A0ABM1AC28_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multidrug resistance-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944860.2">
        <property type="nucleotide sequence ID" value="XM_013089406.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857069"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012944860.2"/>
        </source>
    </evidence>
    <sequence length="240" mass="27484" checksum="613F5C866C4D157C" modified="2025-10-08" version="1">MTVRWSVYLDLLRAYGYKYACVSVLFVLGFHFAYNFSYTWLAQWSDDHDLANFTTLPAASGGRWDRNWHYIKIYAGLGVVQTACCMTYSAIMQYRHVVTSRVIHANMLDALMRTPMSFFDTTPMGRILNRFSQDLDVLDSDLFLELEVVIEHGLFAVGITVVICVTFPPFVGVLVPLIIIFYFIQQFYIRSSCQLQRIASNNRSPVFAHFSETLSGVGVIRAHQAQNRFIHDSESKVDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD02</accession>
    <name>A0ABM1AD02_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101859288</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101859288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945347.1">
        <property type="nucleotide sequence ID" value="XM_013089893.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859288"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21965">
        <property type="entry name" value="Zn-C2H2_CALCOCO1_TAX1BP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041641">
        <property type="entry name" value="CALCOCO1/2_Zn_UBZ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18112">
        <property type="entry name" value="Zn-C2H2_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51905">
        <property type="entry name" value="ZF_UBZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ1-type" evidence="8">
        <location>
            <begin position="842"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="646"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="721"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012945347.1"/>
        </source>
    </evidence>
    <sequence length="879" mass="93249" checksum="EC6F16AE80D6CE65" modified="2025-10-08" version="1">MKTAFENDRLLHFRTFSPHLGSVMETAGGSGGGGSRDSNRGSYELYDDQRAPGKLAGEPPTNRPSPNVGQAAPGCPGSLSESTQKVEELERQLMDMKLREDKLLQIISDLRSAHGGHTSNIALDSAPFLNMDGATGSPSSESVGENVKDARMKYLQRQVTVLQANMYKAEGWGQRATEAMKERDKAVDECRLTSGQLAKALQENESLRQELSKLNAGYLELQQKLRLTMQELDTESRHERCQSQAAKLQEEVTSLRSQFLVLKESSLRLSQENKGLRELTSNSGPGSSQSPMSGNSACSQELEYLHSVVDMLKTTVLEQRNFLVSMKVPQQSFSGQTRRPALNGLHDNTSHLGLQLTRDQVAAMSKSASAALGSEYQQIGSPMVPNSSKAASSVLSMFSGQGDTQQLRANGMPVMEARSTAGGSHRALADPISSAQGEQNVPKSFTGTAPLATSGPGAHVQRQLQGSSPVSSPMGSSHNMKMQPTKTTASTREQSQAAQAAQLGRISGGSGVVPQSSASSVAQNVNVNGTTDTLLAVPSGRKISSEILAYRQSPDQGLNINHGGSKSDILQRNQNKLATEGKNFPNWLYSSTSGYGYQQGSAPGGGGSGGIGQFQATGAGKSALAVAGLSGHSPVAYEGAMMLPEQEQGVPSPRHNVSSAVQTASSQDPHASAVGNHAGGVPQGSHPSAQQQHIYRPPMLFADNASSLRLANVDMKSGGLMAATPGSSSAVSDQRPPSHSGLDNGQKLQEWLSGPTPASGGGGRTGNRDGPPIGASPAVAFNGGSFESAVEPPRAHLNSDRICPVCSKDYSEVSMEDFQTHVFECFDDENTPETMRPEVSLDRTCPMCNGKFSQEMSQQDFEAHVHSHFGEEVFTLLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AD22</accession>
    <name>A0ABM1AD22_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SCO-spondin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101853361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945382.1">
        <property type="nucleotide sequence ID" value="XM_013089928.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853361"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF53">
        <property type="entry name" value="HEMICENTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046099089" evidence="4">
        <location>
            <begin position="23"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="5">
        <location>
            <begin position="1291"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012945382.1"/>
        </source>
    </evidence>
    <sequence length="1373" mass="153638" checksum="63401D4871C8A30F" modified="2025-10-08" version="1">MKGSGFAPLLLGLSLAVSLVQSSGHSSKHGGAAQRSNKFTDTKTSADSDDVIPLPEPMIKVRVIKKHQHGKEGLGEVRELSRAAAGGQDIATGGGWSGRERGAEEEMTKDDASDHVDTGVRPGKNTERTPPKPESLSFGLDSGTDERYKTPQKNKAEKLLVGGGQDWVAPTSMSFMDKVSNLVRSAMGLLEKQEHLKEDDGARSSGEDSEFKTKAQDSNKESISDYTKNKKKVNTLEKTVTRGIDEGSNSTPTEQMMRDQRMVSSHGVAFPGVLIEEKNVSELPAKNAQLDKRKKTTVNVRGAMKDKSAGVRAETDRKMKVKLRGDRKPKNNKRHWWKKGGKSKRKNKKEWRKNHDGGKSLDNGSVQTGKLSDEKLFDRKKSDGTPSNGYSVVPQGHEETVEPSHVGHSDLQDDEGWGWGGWGDGDDSEEEDGWEDEEDSLEEEKGEGEAEDGGANVVKNVDSKDAPHDDNDDDDEDDSNGDLGSDVVLGGEKDNILPSNLIRIDYPEYTNGYEESFYQLQRLTRYYAKCETCMVSSRTGQCPYYRGQTSQLRAVVDDLNSLFTLGCGLDSRNGGKQCCHTRTGELTKAVEQLTRAGQSLVSVLRHQCNKCPVDCEWEAWSAWSDCPPCQSGHRRNRNRRERFPSYGGRPCPGPNLQVESCPAVNVTIGIWSPWSAWSQCSRHCQGLQTRKRQCGRDDRRGFSGPIGCFAPCQGDNVQTVACGRDRCCYDRQWSTWGHWEPCTDPKVGRSKKSRRRLCSNHPSFPNEAMCPDPCPGVSVQEMDCPICEDSRWTEWGEWSTCSGRHVQSDRDTGRPCGRGQRSRSRSCVESQCGGRSCVGRRMEAMDCNLGPCCEPPEWGRWGSWSACSVSVGMGVAKRSRLCRSRPQYWSSPTCHIGGCNGQGSKLNREDFEMMNCSGICQEPCIDSEWGTWGSWSVYDKDTGESKRVRCCIRHRDSADHCKHECVGEKEQVDQRPCVSPRWGEWASWSVCVVNNGRYSRSRDRDCVVRTPYERCLRECTGAESESEECPCDAPYLSEWTFWSSCVGSDTVRTRSRSCVTDPRCPDQECRGHTQDSELCPCTAPYLSEWTLWSSCVGSDTVRTRSRSCVTDPRCPDQVCRGHTEDRKPCPCRKPTWSGWSSWSACQGGSIHRTRTCDRRGVEPNCNTDCWGVAREEMPCPCTWANWVVKTDCETSVRRRRVRVCTATTFRHVCRPGDCPGSDTQDNPCEVDCDEGAWATWSHWGDCSCDKLKQVQTRVREKRSRTSRELCLPERQKEERHSCHDECRTGCAEICAEDPVARDSKRFPSCGKNCNFYVQCCEGNTTTVACPDNTFYDSECRECLPVSRTCNKSTGYVDIHVSRFDIAYRTCEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEZ4</accession>
    <name>A0ABM1AEZ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC106013979</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106013979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946400.1">
        <property type="nucleotide sequence ID" value="XM_013090946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013979"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF109">
        <property type="entry name" value="ZINC FINGER PROTEIN 845-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="869"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="768"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="948"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012946400.1"/>
        </source>
    </evidence>
    <sequence length="995" mass="109556" checksum="2642D07515518722" modified="2025-10-08" version="1">FRADPEVIPASCDEEEEQRGSRDGLREERKERERLERSVSHETAAAARMLSEGRSNLVARDADGRPSRAMTLDPSLYRREQGFFPGRHGGPVPSPTTHRPPFGAAMRQLPSGAPRHPNFPFGKELAGHFSVPGMTPDLSGGPPMPPSGPPFLPGVGGNPGEDKFWEHARSHIKEDKLLQCPKCAFVTEYKHHLEYHLRNHFGSKPFKCNKCNYTCVNKSMLNSHMKSHTNVYQYRCSDCTYATKYCHSLKLHLKKYDHKPATVLNQDGSLPQGVDADASGLSIITKRGPPRGPRGSRKEKGGGDPYMRQLFGMPPMPMSVPGMNPVLNGMMPFWPMLPHSGIPGHPSPQPGMLPGMGNLARHMGMRPEAPGMDAGSGNELNESNTSEDSSYQLREDADAHVCRLCEHVAESSEALCLHFLQAHKDETGAGEVARMYNISEAALTESLHSNHRGVATTTDSLSGRRMSEPAGETGGSDHEVTETERRNTIAGLLFRDGGEKQTAGGSRLQDMCYPGGECQREEDRPGATDGMDILQQMTLKFGSGTMPDTRGGEDQRQAGVSVTQGQGRRRPGSQHKESPLDLTKPKSVSPALSSNPNSPRRSFENEEEEGEEAIEEEEEEQRRLRCVRDARDGGLSKVTQLLLRKRPAPEDEDVTPVTSSVPPTAPEVPHIVTRKRSRKGKAYKLDTLCRKLQERHTRSPHDTDDSDTDAPFERFQPLHATTGGTHGEGDVGGSTHRQGGSSTEETEVEEGEGLEEGEVPSGTQPSSRTEELKVDPEVTPHKDDESEQTCPPQTDVGPRGLSTASEPVIKVEVVDEGNDTDFKDKSNDTDFKDKSNDNKMAAFDFPGDEDEEDPEVEFEKLKRSLDILNNGLPDEPADADSRSSLVEGKKEREEMTVSNKPVSEAGSDKTEDYVDELEEMEGKGLSDRDSLTGVTPPVGCQDRHRGGEEEEEEEGEEDTKEMINTVLENRKKPLPPAVRRGTDLAWKLLHDPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF86</accession>
    <name>A0ABM1AF86_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ecotropic viral integration site 5 protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946526.1">
        <property type="nucleotide sequence ID" value="XM_013091072.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851705"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF22">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="359"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946526.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="48907" checksum="481DAA2341A5575D" modified="2025-10-08" version="1">MSILCPTVVETSRGAAPFIVTMATSAEQNGVEGKVKDSAGAVGTAAGGDVVGSVVCVDVPTCVNGTTTETMTGTVDQNQNCATAGALADLKNDLRTDLKYDPMEDITDVTPDLTSQSSEGEDKMDGSWENGGSTHTINGDGDGVSKTSSEPEEDSRKPTEEELLRQLEEANRMLEADEKSYPTLAAFSATPGHSRKGSGSSIVSSTSSNSFYSAQNSNECEDPNVDPNQTPVPAAAPPTSTPEPTVKQKKAFLRALGKNRKRILTLKRNSVPDLILNGCESPASSSMPSSPVTKNSPSLMSPAGTEGQGHEGSEQTADPVRTILGTSSETLWEIWGRIINDWEPVRKKPAFLRELVRKGIPHEFRGMAWQLILGVHDSVWKQEYAEHMKKTSPCEKLIRRDIARTFPDHDFFKEKDGFGQESLFNVMKAYSLHDREVGYCQGSGFIVGLLLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFR8</accession>
    <name>A0ABM1AFR8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101845752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946778.1">
        <property type="nucleotide sequence ID" value="XM_013091324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845752"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF185">
        <property type="entry name" value="BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012946778.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59363" checksum="450E78E3B088A3EF" modified="2025-10-08" version="1">MTSSCVQSCRLRKFCLCLCLLVFFWFAGMLYMVTLQNRTLTLATRFYFQHTLLTSRTNNTNNLTSTSSFKDLFYSFREILPGSSRKTDSDETRDESSRPQSGMTSSWSPGTANDVITQLPPPPPSPPPPPSRERLDALTSVFKVKEVDCDGVFSGAKHDIEIAVNVTRQMENNKTIGLSNAFYMEATKNCTDFIQTRGYITSPLTKEEEHFPIAFSILAFTDSEMVERVLRSVYRPQNIYCVHIDKTADEGFFKAVESVVKCFHNVFLAPKRINVQWGSFSVLEPELVCMEALWGYKTWKYFINLTGQELPLKTNYELVKILTAYNGANDVEGTVKRANPERWKKTTPPAGIRPRKGSVHVVINREFVGYILHNDTASALIKWVNTTDIPDETFFTSLNHNPHLGIPGSYKGEPESDTGSRKPFLARFKNWGSPPYKWPCAGYWTRGICILSTGDLPLLKDRPELFANKFHLQKDRVVVGCLEELNYNRTRDEFLGVREFNTSFYESLGFVKDQVKSSSVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFZ1</accession>
    <name>A0ABM1AFZ1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101853836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946897.1">
        <property type="nucleotide sequence ID" value="XM_013091443.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853836"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="9">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012946897.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="50122" checksum="DD5656832584056C" modified="2025-10-08" version="1">MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLSDQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVEGEGEEEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQ37</accession>
    <name>A0ABM1VQ37_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurogenic locus notch homolog protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824529.1">
        <property type="nucleotide sequence ID" value="XM_035968636.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861878"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00286">
        <property type="entry name" value="PTI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824529.1"/>
        </source>
    </evidence>
    <sequence length="1360" mass="144025" checksum="1D2649681EAF9BD2" modified="2025-10-08" version="1">MDVRCDPPFYALSDEGICMPEVPVGQFCTGLGQCVKDADCQTPFGGVCVCSKGFYATGPRGEECAPYKNPGELCLPVDRCVKNAYCDDPTRGLCVCGDAYYATTDDCRPRIKPDLNCTARGQCVRDAECLAGVCECLDDFVSWENRCMPRILVPETCESFGLCVANAECTRGACECNPGYYARSGRCLPLVNATEPCFDGPGTCIANAECVGGRCVCVKGFYAKDGGCLTLIEAENPCNGVGQCVDNAECVGGVCECNIGFFPQNGACVDLIPAKTRCDVSTEVCVDNANCTKGFCQCGPGYFAKNGVCNELIEAKKPCDGIGQCMANAECMRGTCECDPGYFARLGMCEVIKNATQSCEGFVGECVANAKCVMGECVCESGFYAKNGLCRMVNNATQFCDGGIAGECTANSRCVNGRCRCDSGFYNRYGQCESLIKAEKMCEEIAGECVPNAVCTNGECVCAAGYYARMGWCEMVRNATQPCENVVGECVDSATCLLGKCTCDEGFYNKDGLCKNIINATEPCDGTPKECVANARCERRLCTCVDGFYPRKGKCELLLKVPDPCEGVEGECVANAACVDAACACERGFYAKSGLCHVLRNASQPCENLPGECVAHARCLSGTCTCVVGYYDRLGLCAKRINSTDACENVPGECVDFSTCTSGICRCDNGHYAKDGGCQVLIPAENACEGVAGECTANAQCQSGICECLQGFYARQGLCVEKIRVKNPCEGVAQECVANSQCVTGACECVQGYFPKDGFCSGLINASLSCNEAVGGCVANARCVNSQCTCVDDYYAKNGVCEPVVPASGPCEGLLGECTDNARCAQGACTCLSGFYPREGLCREILNATDVCENLAGECTDNSNCVRKVDETCEGAINGECVPNANCLRGRCACDLGYYAKGAFCLRHINATDSCEGVPSECTPFAKCTLGVCQCGDWYYPKDGKCARLINSTNSCDYTPGECVEHASCVGGECVCGEGYYPKDGLCSVLVSVPEPCDYTPGECVEHARCDVLTQTCRCEEGFYDEGGRCFPLRNASQPCSASRQCVMDSSCDGGGVCACDVGFYEMDGRCFLLVNATQRCSLDKQCVNHSACVKDECTCHLGYFPKDGACLVWVNATDPCDAIGQCVPNSECQVFNGGTCVCHEGFFTLHGSCEPIVNASSTCGPLDQCVDNALCNWDTTGTCDCVRGHYTAGGQCPEQINATQKCTAFHQCVPHANCSATKGGLCTCAAGYYATNSSCEQLKKEGETCVSTGQCILNAVCRAGNCTCEPEYFALNGYCPLRKLAGDKCNGSGQCVTHAECTSPDSDGVCRCNAGYYRDPEGRCAGIIPPNKACTGTGQCVANAECSSDVYGVCVCDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQQ6</accession>
    <name>A0ABM1VQQ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Irregular chiasm C-roughest protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101858479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824748.1">
        <property type="nucleotide sequence ID" value="XM_035968855.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858479"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="226"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="336"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="434"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="532"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="611"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824748.1"/>
        </source>
    </evidence>
    <sequence length="894" mass="101776" checksum="A550226B90E74E66" modified="2025-10-08" version="1">MTRSEENSTFGCSSCQHQHCHSHCQRVQPQQQQQQQQQQQQQQQQQQQQQQQIERCPTDSSSVTMLKYWKQQQQQQQQQQRHHTDDYPGNTLLFLHRPRHHHYHHHHHHYSNDTNSTHKQQQQQSLPHRHQHSQQLPSNALTQRQNQHEQQILLCSSSLSQQQQQQQQQQEDQQQQQQQQQQQQYQGKRRSGLSFLPSGMGRLVPGVFLACLTLVLLCQPGDCQQMSFVVEPGNRSVAEGWTVVLNCTVANRQGSVQWTKGGFGLGVNRSLPSFERYSIIGVEQQGTFSEYNLQIRDVRVEDEDVYQCTVMASDDFPVGMRSRKSFVTVVVPPERPTIINAPIVPVVLHTPTNITCRADKGKPVAEITWYLDGQRLSRATTYSLPRGDFYDAVGVLTFNATQADAAKRIECQASTELMARPFRTFATLDVQYAPDLEMTYNVTTRNIREHDFVRFQCVGRANPSNVRWRWFRNDVLIPNANSNTYHVHAITPDYNNDKITCEGTNNVGSTRKDEVLNVEYGARILEITAVVGADVGLSAELKCETDGNPSPNVIWRRKDRSTYAHRTLSTNKVYHIDRVNDQSFGWYVCTATVIGFPDTSQEALLLRNGKPKMGSKKEQLATSGEAGFIECMTKSIPKPSEIVWSRHGQAIDYAMSGRFSQKDHQLPYGVKSILHITSVQDGDFGTYNCTVTNAYGFGFDSIELKEKHVFPTIYVIIGTIGAVVVISVAVLICFLYRRYKKEDQGSVLATTAAGSYTDTDSSSDKKREKADSPNTLMGQLRQDYNKDVYRFSADYDDMPYKYLQEQQSKGNNNGYGFIEPYEPEYASDHQIFDGEYVHRGEDLVPDRYDPAYHSGTGYSLSSFRGNNFDNSTPPPTMTRLTPIHMSNSKLATDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQU2</accession>
    <name>A0ABM1VQU2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Very low-density lipoprotein receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824784.1">
        <property type="nucleotide sequence ID" value="XM_035968891.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849281"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF15">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035824784.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="34908" checksum="ECFB4618F952012F" modified="2025-10-08" version="1">MAISCNNGGCVPASYRCDGFDDCGDNTIPFVSNTGPIKLDVNIVPLEDESLYRKKMCILRIATARLIKDQQSPNYALRLKAVSCESDQFACSDKCINASWVCDGESDCLDGFDEQNCTAGCMGPNKISCNNGGCVPVSSRCDGDNDCGDSTDEKQMNCANSTCQANQFKCDTGACIPDRWRCDDDNDCRDNSDERDCQTCSGPTVFQCNNTVCLYSFELCDGDDDCGDNSDEVGCTCSTDEFTCKSGECLAYHYRCDGQFDCNDNSDEKDCPDIHPAACGDKLTLSDCAHMNVTSYPICQNEDDAFKYCREFCGLCKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VS31</accession>
    <name>A0ABM1VS31_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101857715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825223.1">
        <property type="nucleotide sequence ID" value="XM_035969330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857715"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF241">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035825223.1"/>
        </source>
    </evidence>
    <sequence length="617" mass="69565" checksum="6E696AC7D36D246D" modified="2025-10-08" version="1">MAKSSASSYPNNYTLILDTLDSDRNSEVTSSNGRYVHHPESVPLHDVIVDNDTKRATVDRENEIPTGRPTTEERELYENEASSEDDGVVSRDKWGRKVEYILSMIGFCVGLGNVWRFPYVCMRNGGGAFLIPFIVCLTVCGLPLYFMEVAMGQFVSLSTFHVWNICPLSKGSCLLLHISMRNDSVSSSEEFWIHNVLQLSSGTTDIGGIPWQSGVALLAQAVMVYLCVIKGVHSAGKVVYVTATLPYILLTILLIKGATLPGALDGVIFYLKPDFSKLFRVQTWVEASIQVFYSLGPAWGGLITMSSYNKFNNNCFRDSLLLCFACEGTSVFAGFTIFTLLGHMAHTLNVPISKFANAGPGLAFVVYPEAISYLPVPQLWGVLFFLMLFTLGLDSQFVFCETFLTTVTDVFPWLMKRRQFLFKILFFTVLFVISLPFATEVNQLHVKSSAGGMYLFQLVDWYFAAYVVIVDSILELFVVSWIYGAERFYDDIQLMLGYRPPYIFAIFWRFLTPLFLMTVLVNTLRTYGPPVYKDYHYSQTEVAIGWCLATVSFLPVPIFALYMLVKTPGSFIQRLKITCRPSRQWVPAEPKLRDEYRAESRQKQLCTFPVPCLGQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSP5</accession>
    <name>A0ABM1VSP5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101848657</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="RefSeq" id="XP_035825437.1">
        <property type="nucleotide sequence ID" value="XM_035969544.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848657"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="11">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="12">
        <location>
            <begin position="184"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035825437.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="54598" checksum="B636774EE32A2E60" modified="2025-10-08" version="1">MPIKYLLELRCSMLDNVWGKTGRDSLVARLKESTDEHFVAHPSSHYAQLWMGPEPEHLVSVKLEEGEMTLQDWVKEYPEQLGSTVNKTFGGKLPFLLKVLSIQTVLPLQAHPNKELAEKLHLANSKEYKDDHHKPEMMVALTPFAGLFGFRKVQELCSFVARIPELRKVLETIPDELFDEVVTENGQQFKQDGQEDTMKECFKALMRADKDTVSTELVNLAERITRMKKNGEDISHLEGEVFLKVYEDYPGDRGCFSIYFLNVLHLTPGEAVFVNTSVPHAYISGEKNGEDISHLEGEVFLKVYEDYPGDRGCFSIYFLNVLHLTPGEAVFVNTSVPHAYISGDCVECMASSDNLIRGAFTQKHMDIDTLIEMLDYSDAYAICPKLQGEDISKNDVRVTRFSTPFPDFGITKYEVPNHNESFEMDAICSPSICIVIKGHGTATCQRGAPATLSLKEGSTFFLAADTVMAVSCAGSGMLLYRGHVRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSQ3</accession>
    <name>A0ABM1VSQ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864458</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825445.1">
        <property type="nucleotide sequence ID" value="XM_035969552.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864458"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034754">
        <property type="entry name" value="GEMIN8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16238">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16238:SF7">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15348">
        <property type="entry name" value="GEMIN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035825445.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="49547" checksum="052A2AFCFB2AA65A" modified="2025-10-08" version="1">MAEKGQTSSMTSVTEEDSSADSESDTTESSYSLVTSSVLSSSDYNTDDKLTPGLVSISISKTPTRDALKQGKSKLGIGNVTEGYFGCKRESTKECSNKDLKTISQAAVELPVAPLFPYGSNPLPLRKASADNSYKNSQKLWTYCDRERCVENLGVDDPENRLSTDFSDTSSICKDPDKTLTNDNTVQDSVDIDSSNGASNSENSSRGSKQKSDERPHLPDLSSATWYQAQCFDRYWSNYRFVMDWYQLHLKTVQKLSGFKMGVGAAANVSHQGRRQQSSNRARKARRSRRARNRRLAKERQRVGSADNVASHGDNSRTETAVSGSSRPSDEEMKMEITDEMVEFFTTSYKHKMERDTKKKMEGKSEEEDAHVNIDQVVSGQQAPSTSAPAEQPGLRRTAELKYLYGTDAPMIHGMETALQLTFDRVSDKCQPKLWPNMPLKINFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTX6</accession>
    <name>A0ABM1VTX6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Guanylate cyclase</fullName>
            <ecNumber evidence="2 14">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101862233</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 14"/>
    <dbReference type="RefSeq" id="XP_035825868.1">
        <property type="nucleotide sequence ID" value="XM_035969975.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862233"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF502">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="153"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="482"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="669"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035825868.1"/>
        </source>
    </evidence>
    <sequence length="729" mass="82309" checksum="2F787E9A75F1A9C6" modified="2025-10-08" version="1">MERITGNVKVDANGDREPDYWMWDMAPGTDNFSVILEARMTAISKQKIFILGDIVWQTADGSVPLDVPVCGFFSELCPVDLTERNTIIIVAVIVLASLIATGMAVTWYIRKMKREKELDQMLWQILYQDIRFTKSKCMGSISQMSLHTLQSVTQQSGRLSGTGEGQLFSAIGMYRGRLVAIKKLSTIKVTVTRPDKVHFQQMRDLQHENLNPFIGICLDERFPCVLSTYCAKGSVQDIIEHEDIKLDWMFKISLLTDMTNLLEAGLEKRNDTNIVLLEIQPELIEDSISDVIDKRGKFWTAPEILRSGVDLKSHLELQKADIYSYGIVLWEILHRNEPYDTQYYTPKEIVERIRVTENPPYRPDVNHHADLSSPDPDIPSVAFDVVETCVEQVPEKRPNIEIVKSNWNSVNKGKRVNIVDNMVCMLERYANNLEDIVELRTSALIEERKKSDTLLYRMLPRVVAEKLKLGQTVCPEMFESVTIYFSDIVGFTSLAGDSSPMEIVDLLNDLYTRFDFVIAQHNVYKVETIGDAYMVASGLPIRNKNRHVMEIANMALDLLTSIFTFRIRHQPDKQMLLRIGLHTGPCAAGVVGLTMPRYCLFGDTVNMASRMESTGEPLKIHVSEDTYQALTDFGGYRMTVRGNRDVKGKGMCTTYWLLGKACPPISINQDNSAPNTSTNSDHLIKSQPGAKAVHSIDDPWAHNVSRLSPSSETSVNKTLPGELHQSSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUA5</accession>
    <name>A0ABM1VUA5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neo-calmodulin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106011939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825997.1">
        <property type="nucleotide sequence ID" value="XM_035970104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011939"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035825997.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24515" checksum="BF0A12CF7169FF04" modified="2025-10-08" version="1">MVAYAEADRLSHEQIAEFKEAFSLFDKSGDGTITTKELDIVLRSLGQNPTEGELRHMINEVDQDGELMSLQTRSLRDHTSYLQKFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDADTEEELKESFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADTDGDGQVNYDGELTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUN6</accession>
    <name>A0ABM1VUN6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857414</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_035826128.1">
        <property type="nucleotide sequence ID" value="XM_035970235.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857414"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035826128.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42845" checksum="DF53EE3B28EB46A5" modified="2025-10-08" version="1">MKASVSIGSAPYLPNPHKLVAMRLGSRLLILVVALGVVVPIVVLFSSLDTGLGKIRGTQPSNTAATRGAMQESTVQDPQGRAGSSRLISPMWWTNHIHSTCERLGYQKPRVEEIKPEMFKKILVDDDNKLLYCQIPKVASTTWRRVFLLLSGKMNTTNPLELRSNDVHHKYDEFLTYLSDFSTSDIMYRLNHYFKFVFVREPFERLLSAFRNKFETNTLSAAYFRKQFGRKIIEKYRENPTKEAVELGTDLKFEEFVNYLTDPKRKLHLNEHWDKFQDLCHPCIVNYDFIGKLPNIDKDSGYVLERTGIADKVKFPSRSESKYGRLGTDSYMKKYYTQIPKKSLIQLFNMYKADFAIFNFTIPEVIKEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUS1</accession>
    <name>A0ABM1VUS1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101847194</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826163.1">
        <property type="nucleotide sequence ID" value="XM_035970270.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847194"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1511"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1945"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1623"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826163.1"/>
        </source>
    </evidence>
    <sequence length="2037" mass="234515" checksum="2FC5167C7414AE8D" modified="2025-10-08" version="1">MGILDFETVFDELDSSRKGYVTIDQVKYFLESIFEDIADDKHVYLSVEKICGPGSETIPKERFYLVLEEIERRKTLDSEAYWDFQALDYSGSGLIALKDALLLFQEYHADQFSLDTWHEFLCSRDSPDADVYFNEIRDWLCDIPRSSYPSTKSEVRKERASLEHRRTDAAYQDLEDMKVLLQDEDLDRQERGERTEDILHHSKRKLNKWNQHGLDSLLHDDGLGQTEGDEQMSKLSDTVTTSNVMEALDLKYSLLQDKVIVEMASFAANMDSEKSETFQQIKRLVTASIKSKSLAENVDDLPGAKVELSMSLLGLIGDLHSAEANRKEKFKSLASELQTEERTDEQVDAELAERYKRDVAGPRSCGAILTQLDMRHKAERDAVLHSLHQSSSSLPPSAVLALAYWHLLRQLRLLQLEPFVTSAAISVGLAERKQEYKPKRYDWDRQRSEILANLRLESRRGHRPIKRSTAAPDLDSLQSLALAGIKQRLVEEMEQRYFLEREAMVFLLQGPDSKSSFEAAAKMSPDERKLRIRTLRNQREEWKMMNNSDSSVNHKLLQEATGLYFEQSRADVESKDHNATDSTVMSFVLADLQQRQEVEFEKTVSEIHKKNAQEVTRLVLSEIEATKEEHFNSIAYVILGCVDLSAEDTAFLKVLDGKYKALRDQVFVFGLVDKMGSEWKGLSKENKQREILRQRKEEKRLRGEGLLEQMSALIGPRSQALALLPTLVGEDKVFPNSSPPQTSESRSINLLADLVPRFDQEQDSLVSWLRSEEVKGSTLRSKHGQLTRIAMEKFAASAERDHETALLFVGLLERIGMALSGRSKSDREKQILLAQKRATLRKKCVNQGEKQKPPPEEKDKSNENDERTMQAIYMRAVLRRHYKEREVMLNLLQDEGMEELLEAAAVMSVDQGRKRMQELQDKRENMDLDDKANQEEHTSILEEAGAIRCASKKFAMVMDGGRAVLMDEVVVQLLAELQDLQDRDLATILNQLGTLNGHEMQEKAWAEEKAKKNSHSHLVMKVFMKFDGGSSDIDFDQLLDAKYRKLRDHLIDECLSQRQGKLKWAKMGQKQKNKLISTFQAKESALWNEGDSGSLSACLTPAFTLKPTLPYLSGMSRQQYSSAVWAGSEDPIQENEGLNPDDQGNGETISFLHRRYMAEVDFVKNYIAGCLEKVPEESDKKLLENKLKWECQLVSSVGDFVTASLVCGLAERQNTDRVFRLKLDHDRYGLLAQQLLACKREQIKKSADIVKGDDVNKLQEAVMTLLHKKHQDEWNILCQMMASDRFKEVRELVATETQQQKSDRLMVLHGIREKFDLAASSEHQTILEEAVTVKREMRRCHLSGQSSSGEVGDSEVNVSLMADLLKTQLVEAEIYLGAFSAESNEDLIENQQAIAAELTQSHAINIADVVFAAEGHDSADSQNQDGLLEEAVDGKYDALRDQLLIQALINEMGEAEWNRLSEKERQRRLMELKLKERQLRREGRYDEAAALLGSLLNDEEKLRQLLGDSKAEQERKLRERLERRKKRLAEGMTEEECDELEAEEIAREEEEEREKKKNILLYLEHCHDEEKAALLRRLAEMKDESEKQRQKQLEMLRLRREQRRLREEDKFDSAAMVLGLSEENDKRHKMSKDEERQRQQDLARQRLEAARQRKLQGENMVRGETIVLPEGEMEDESKVGETALRMLDRRHQLERDLLIKLLDEGSESEQRDEVRVLTDDELKMKLLAAQELYELWRNSDSGEKEDGEKILAEVAVLSLEVKKRDMQADGELASDEDVKVALLAELQMKQDGEAAQMMETLTTVDNEHKKQILNSQRKQLEDKRYDNVAGILFTFANEEDIFGEGKGEDEEEKTEEEKEDDKVVKALEKKYDAMRDKLLIEALMKEMGEGDWNRLSELERQKKLLELKMKEKRLRREGKMDEVAALLGQFLDDNEEMRRMLGETEEDQKRRMQEKLALRRKLKEEREAQGLAVDDETLDELVEEEDKKIRRRNVLENLDHQFEAEKAALLAAFKRQNDQLEREKERQLAVAKLKEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVZ9</accession>
    <name>A0ABM1VVZ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein HtrL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826591.1">
        <property type="nucleotide sequence ID" value="XM_035970698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860027"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826591.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="39033" checksum="5115413DE37168A5" modified="2025-10-08" version="1">MRAGSRSRKMFHLSPARRKVAITTAAIVFILMTMTLYRWGYQNEKKTMEDAYMAMSWEGFGPERGLYNFTVVTAMVDIGRGSWGQQRRTYNTYLMYMQRVLRLDVNMVVFVDAKGKPFIDWMRRGRENRTNIVVQDFKALPYYKLRGRMSEIMKSPEYQQDNELVWKQLCESYIPEYDILQLSKLYFMDRVVRDNPFGTTYFMWMDGGYGHGHDIHPSDGVWVPKGLFDHPDQVTFMERPPGVRKFEPVKHKIHKMSINILAGLFFAGGGGAFKELYDMQKKQVETWMQEGVVDDDQTMYMLLYYKKPSLFHLVPGDWYDVFSLFNSHVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW86</accession>
    <name>A0ABM1VW86_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="20 21">Nucleobindin-2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">LOC101845252</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleobindin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940282.2">
        <property type="nucleotide sequence ID" value="XM_013084828.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826678.1">
        <property type="nucleotide sequence ID" value="XM_035970785.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845252"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057576">
        <property type="entry name" value="NUCB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25434">
        <property type="entry name" value="NUCB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045023433" evidence="17">
        <location>
            <begin position="24"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="367"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="380"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012940282.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035826678.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="63185" checksum="88E0A320EF381BF7" modified="2025-10-08" version="1">MGDYRLPRLLLVLGLLCVPLIMGKPVRRGPPAPKPVEENSPEDVDNTGLAYDSYLRQVVEVLESDSEFRKKLETANVTDIKSGKIAMYLEMVNHTIRTSLDEIKRREVARLQDLARLEMQAVSGTELIMNALLGGGIKNMEIPSHLDVRNPHSFEMKDLEALIKKTTSDLEELDKKRRGEFKEYEMEKEFEKQEHLRELPEEERKKEEHRLEELKKKHAEHPKLNHPGSRDQFEEVWDKVDHLEDQEFNPKTFFFKHDLNGDMEWSIEEVDAVLQIELDKVYDARNSPDEDDPMERQEEMNRMREHVFQEMDKDHNQRISFEEFIEYTGAMGDNEEFKKDEGWKTVDEEPVFTDEDYMQYIQEHHAQPGVVNPPPDLRFQQEQHLQQQQFQQQQQQFQQQQQQFQQQQHQQQQFQQHPGQQQQFQQPPQHQQQQFQQPPQQQQFQQPPQQQQQFQQPPGQQQPAQPPASQQVNQQQQQQQQQQQQQQPSQLNMNQQPVADQQQMQQQLKDLQEKLNQQQQGQQQQQQHKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXE0</accession>
    <name>A0ABM1VXE0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101857965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827083.1">
        <property type="nucleotide sequence ID" value="XM_035971190.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857965"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035827083.1"/>
        </source>
    </evidence>
    <sequence length="747" mass="85132" checksum="CB4F829DBE6C6C17" modified="2025-10-08" version="1">MADTRRDDDFDAVPTVEEIEEERKLFSNSPEKFELRSASPRGEDDDIDAADGRVLKDYGDPVKYDPSFKGPIHDRSCTDIICCFIFVVFLLGMGVVSVIGYARGDPYRLVYPTDSHGSICGLGKLEDKPYLFFFDLVTCAKMGPAVVTGCPTPQVCVKECPSENTVHMAMDRSQLICKYAVDVNKSPYREMSTDTLVKRNLCASYYLESKPIINRCMPKIFAKTFDLAETLVDEQGQNQLVRANGEQVNGNLLKEGTINLAHFYKLKGTMELLFRDVQNSAHLIAICLVITMVLSMLWIVLLRWLTIVMVWVTVVLFIGLFGFGTGYSYYRYYELKNANVTEEYGLPYEFKFDFDYYLSQKTTWLAFGCTGATIFIIFLLIIIFLCGRIMLAARLISEASVAVSHMWCSLFWPLLPFLAQILILAYWISSMVYISSMGEPEFYNNTVVTSNDVDALLTRLPCDHASNDTLGEICSFVKYGGNTYKTAMLVYMLFMFFWLMNFVSALEQMTLAGAFASYYWAWDKKKDIPAFPLGSSFGRSLRYHMGSLAFGSLIIAIVQMIRSFLEYINRKLKGSENSVAKFLLKCLRCCFWCLEKFLRYVNKNAYILIAVHGRSFCSAARDGFMLIMRNVLRAVILDKVCDFLMLISKLMVTGAITVLAFFWFQGDLPLFEKVTPDLNYFLAPVILVSIGTYLIADSFFDVYSMAVDTIFICFLEDLERNDGSDERPYYMSKTKNLKRLLYVPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXF9</accession>
    <name>A0ABM1VXF9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC101862200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101862200</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941130.1">
        <property type="nucleotide sequence ID" value="XM_013085676.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827102.1">
        <property type="nucleotide sequence ID" value="XM_035971209.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862200"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012941130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035827102.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43881" checksum="E03354E1B6F1D106" modified="2025-10-08" version="1">MVDEITTRYGLQEQHVVSIYRNPTSFNIYITLVDTVPETLLHDTQFQIDSYTHAYIQKLTREKKKLYLSWVPPSFPPDVVEDILYTFLDKNKPITILPQKHNHNADRYLILAEFQEDDIPHYVQVTLDNTEKTPELIDILVTLPNRPVACHSCGVPGHWASNCPRVTGRYPQHQPPPPTTSTTTTTNSYSNALRQAPKQNRGHIQKTALLPTPTTPAQQDPATPRPASPRPKPRPSSPPPDPPTVDLTSPTPTPNTTETDPTAHPNTPHTDTACSFARHLTTNRRHQHARPSTIRLGQRKRKYCLVRPTNRKHRNRLQGSTEKRQGEKKSRSQLSRLRLLLRLVCGRREANKCLPRSSDDERNRGPSLLVHESRPSSRRHAIGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VY90</accession>
    <name>A0ABM1VY90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitogen-activated protein kinase-binding protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827383.1">
        <property type="nucleotide sequence ID" value="XM_035971490.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847360"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055292">
        <property type="entry name" value="MABP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056162">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24782">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="MABP1/WDR62 second WD40" evidence="4">
        <location>
            <begin position="375"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="502"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="682"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="768"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="865"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1184"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1271"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1695"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2047"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1995"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="887"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="938"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1295"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1318"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1353"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1385"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1396"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1411"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1440"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1538"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1580"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1603"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1708"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1761"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1805"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1838"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1856"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1913"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1971"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2048"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2063"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2090"/>
            <end position="2100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035827383.1"/>
        </source>
    </evidence>
    <sequence length="2158" mass="235271" checksum="5B1AE3F56F505007" modified="2025-10-08" version="1">MDSVRPQRKVLRSPSVKRKSKVLPVNQRVHLERVLGVTVSSNAGLSCDSNNGTIAYPAGCVVVLFNPRRNKQSHIFNASKKTITALAISSDGKLLATGETGHQPAVRVWDVVEKTQLAEFRGHKFGINCVAFSPNTKELVSVGTQHDMMINVWNWKTGVKVASNKVSSKVSSVAFSQDGKSFVTVGNRHVRFWYLEDRRSKINQTVPLQGRSGILGDQKDNFFCDVAPGVGPMSGRFFVITQSGLLCEFNEKRQLDKWVELRTKSANCITAGMEHIFVGCAEGVARVFSATSLHYICSLPKPHHLGVEVTTATSPSAMVNNSEGARYPDVMAIAMDDDHKKVTCVYNDRSVYIWDVHDLKRVGKAWSFLYHSGCIWALEVYPQIEDGSKAMLPPGSFLTASGDDTIRVWNLNPHMPEDTAYKRNIYSNELLKIVYSDPSLNSLCNVDYNPAGATDKTDTSYDGKNGVRSIRVSPNGADLASGDRQGNIRIYDMQYLEEKRSIEAHESDVMCLEYSYTNSGHLLATASRDRLIHVFDVEQNYGLLQTLGDHSSSITAVRFTDTDNKLRMISCGADKSILLRNAVTSPDFQFQLEQHLATKITLYDMVIDPTQKCLATACQDRNVRLYNIQTTKEKKCYRGSVGDEGILLRIHLDPSGTYAVTTCTDKNVCILDFHTGEVVATMYGHSEVITGVKFANDLKHVITVSADGCIFVWRLPSEMSAQIKGRLSDLGKIMKDTDFIRSDQPLMPNPVVLGDHSSDGNFPVVKSASISHIPMPDDESVDGREDYDDEDDDAFHPKETFDDTASQVSLDYRFSVGELPNWAKSKKTGEADGADSSMEMSQPKGRWAQRVDRNVEFKSQLDLTSEDDTFSDRRRTLGPESVASQRAELRRETRVLSRPSGDKHNLPIIGDELRASTGDLRSSLPITPKTIRDASPRSRGTFSQYSSDTTLNLSGPSSRWADRFVDFKSNSLEFDDTDELDTGSDTTEVIYPPTDGDSDLFASSYKVFAVDDVKKQKSRTSVGNVANLDDASESTDPISLEDEEDPNDDTLAVSNPTTPSDPDKDFLSRTPEDKADFVRENFEEDSFTPVPLEKFTKNIENLERQILEGTPKAASESTPFSPRLSLSARFMSRSQQAGFKNFSSLAPTSHRPDNWFSRNKMEMTRAMDETRKSLLAARRSIESSVKMNLRSDSNESDSPDREDPPSPPTRLEQEESKFASSSSFASSPPTVFVSPPWGYCSKNLRRLWSTFSLSQESIKEEIPGLYSSRAVRRPCCQPNPRLLKPPNQPRPPHQLYQSRIPTPCSSPRPSRVRKGGVSSPSHLSTNVTPSGGSNSPASRRQSRAEAPAHTSRSRSQGSSSSRNSSCKGSPLSRPCRRGQGAELQARLKDSQKDPLSKSQSPLSSSSVGASNHVTPPIISSVTARRISQERERRRSSSSRTPEQSNEIRANAESAGNTSSDSGTPTKSTMRTRPTYFKTTQSSRNKVSKSGDGILSSSMPADASSKAKDLAAKKTRRSGRLPGSKLAMYASTPNLISGMEDDDAEDEDEDKPQMAVKLVSTSNLKLLSDLSRSVPDVNEVDSSTDSSSCGSGPSRPTSRRSGSFVQSKMRFSTAPTDKQLMPPPTGAVRPIIQGRKNSSSDGKSRRKSSTSEMTLDQAKSILLGKSGILGAGGSKAENVIAPSHPSLTVGIASLQASGRVASQRDSRESSSSLSSVSTLTSGQSPPVFDAASNGIPTPAQLAVAEEIEHTANMLRHQKQANLSSSSFSPDRLLSHPPTDLEASPLDLPERDQPSPNQKRSSPKPPQVSSSLQQPQPPSSSSSPGHPAMSSASPAFHSLGSRTSTANTTFFMGQPGENEGDVFEKEEEEENPRSIRERIAMYQKEAAKDVSGSPGLQIGGSSSVNRRVLPASPGVLSSPQNTSQSDTGLGSESSDTDTPAAQINTATYSITVKPGVHESSPSQPGDRSRLALSLQSTHSSGQVSSTNTSISQCQTFLADFRSQLQKLKDLFSQVEDKSDETSQEILGMLGSAVQEANSVIMEIVAKSPGSPLTNGDSQQNTLCESSLSTSSSSKASLSSSSPPSQGLYKDTFQPSETDTVSANHGDEPRKSQVSSLSAGEHTVLLSSAKEMLQPLVDQLSRDLSQEIVHLIREKLDKMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZN0</accession>
    <name>A0ABM1VZN0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium- and chloride-dependent glycine transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101849721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035827873.1">
        <property type="nucleotide sequence ID" value="XM_035971980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849721"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827873.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39293" checksum="693C02781D0EC353" modified="2025-10-08" version="1">MAYPLYYAAMSCQPDLPWASCGHSWNTDNCREANYTARSLEVLDAVVVAVTNGTEQLINGTTQLGSDVHNVTDDQGSVLRNITALNGTVRGPEEEFWLYGVLDISSGLSDSGSVRWPLLICLAVAWFTIFLCLIKGIKSMGKAAYVAASLPYLILTCLLVRGCLLPGAGVGLYYYMVPEWEQLADFDVWRNATAQVMFSMGMGSGLLNTLASYNKFNNNLQRDAFLLPVMDTVTSIFAGLVIFVYLGHMSYLTGKHMDNVVDEGPGLVFIAYPSALSTLPIPQFWSIIFFLMLFCVGLDSQFLHVQIVITALTDRYPHKLRSRGRLLTAVVCFIFFLLGLPYTMQASFLPAMASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0H7</accession>
    <name>A0ABM1W0H7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine-rich secretory protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828170.1">
        <property type="nucleotide sequence ID" value="XM_035972277.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478515"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047079363" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828170.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15986" checksum="FBDC2107F6281C45" modified="2025-10-08" version="1">MSRPAHLALCVLLVVSWCSGQDHVLTVQDAREILDQHNDYRREEGAADMYLLHWNTSLQERANTWAHKCNFRHEHNIDVGENLFFDNDHKEKVLMRGLKAWFVEKELWSFAMPTCGDACHYTQVQVYLWWLTGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1F8</accession>
    <name>A0ABM1W1F8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Low-density lipoprotein receptor-related protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101845746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828501.1">
        <property type="nucleotide sequence ID" value="XM_035972608.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845746"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="3">
        <location>
            <begin position="293"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="3">
        <location>
            <begin position="336"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="484"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="3">
        <location>
            <begin position="739"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828501.1"/>
        </source>
    </evidence>
    <sequence length="807" mass="88521" checksum="EEFB5661B3097781" modified="2025-10-08" version="1">MVFVNPQSCYVEQMMDSNAITYYNMGCEKRLICDVLGNGELVGKRNVRSEPDKHPVTRDVTLCNKCCLTDNCNSELCVDRETSPTVGIPASADIYVRLIGGTNAFEGTVEVFYNNQWGTICDDKWSGNDAKVVCKMLGYKGDGAGGLTGGAFRPGLGSRIWLENVNCTGDEASLIDCPHGQWGIHDCDHGEDAGVMCPAVTPEDDVIFLLDTGLGGMIFRMDLRSQSFTPIPINRLYSPSSFDYDPSMGRIYFVDPRLFQIVTVNFDGTDAKNIHQLTSSAILEKVEVDPLNRLLFYTDAGNDVIAMMNLDGSGYKEVITSGLDQPREIVLDPTTKTMYWSDWGANPKIESASYDGSNRKTLTDTGIQWPNGLAIDYDAKKLYFVDGGTGTIETMTLQGGSRREILKDVGSHFFAIDVFDDYLYYTDWNHNTLMRVNKDGTGKTTVGPPSFRELADVKVHKYGYDLPGVTTPSPVHFDPSHIFVRLAGKGYANEGRVEVYANGQWGSVCDDHWDDNDANVVCGMLGFDRYNAIATNESAQGGAGGLISLDEVHCQGTESHIAECGLTPDNWAIHDCGHDEDAGVVCSTGTYVHVSKTTGTTSGANEDFLLFSDAYTGLLVRMDLNSYSFTAISQPYTANLVAVSFDSTDQNIYFSEVYPNPASVIKKSDVLGKNIQLLGSPMNGSIVDGMAIDHVQNLMIYSDAGKKAIVSISLGGGAPKTIVTGVDQPRAIALDTNNRMVYWTDWGTSPKIERAMYDGSQRTVLASQRLKFPNGLALDNKESTQWHHLDTLKMSLKDFNMEGFIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W211</accession>
    <name>A0ABM1W211_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phospholipid-transporting ATPase ABCA7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101862380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828704.1">
        <property type="nucleotide sequence ID" value="XM_035972811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862380"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF185">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1473"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1759"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1811"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1841"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1870"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1959"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="954"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="2019"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1189"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1352"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2338"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2382"/>
            <end position="2432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1193"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1373"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2339"/>
            <end position="2363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035828704.1"/>
        </source>
    </evidence>
    <sequence length="2432" mass="272227" checksum="2C6F34BFB3C90C12" modified="2025-10-08" version="1">MAFFMQLRMLLWKNFVLRKRQPFRVVVEIVWPLCLFMILLAVRFRPDIRENIPECHYSPRAMPSAGTLAFLQSYVCTFDNKCYPNATSAGTNVQGSINTFNSSLLDVAVRDLEQILTDNDFSTLTNDLELLLNFVNALQNGTSAAGDVGIRVSNVILDRQSLLDIVANQSINLTPDAIDTLLNASLNVQNVLADFNQTNADNLVTLINDIAEVQAAQTPDNVTVQEIQRLLCEDEILLRYFDFNSQSDAETLQEQLCNLTAQELTTFAIDVYNDVNSTLVMDEFSNIVNDVTGQRPTNLEDNVIYQLLVNNASSLASFLPVAADLGSALQQLNVGSDSGSVTSLLGPLVCGGSGQFLALSEDSEQDLQQDQDGGAGSGGGSTQPPKNLPPERGIPDECVDVVDSIRSTQSGSLLWRQLKPIVLGVIPFYPNSPAARKVMEEAASTFNDISVLFNLSVNIESQLDSLEAFLENDIGFLRDFFASEMCRNLVGFSTLLGNSPQMQQVQTALSAFGGLSCENISNFIALEDRNDTYTWRDALNNTRQLFDSIQNFSKCIMLDKFVGYDSLNELVEASLEHIENNTFLAAVVFDNIGPSDVSLPSTIKYRIRMDIDKVDSTKKIENKYFRPGPRDGINDLKYFTFWFIFLQDMVDHAIIRLQTNSTDGPGVYMQQFPYPCWISDRFIFAISRTLPLFMVISWIYSVAMIVKGIVYEKELRLKEVMKIMGLGNGVHWLAWFINAFVMMLISVILFVAIVKVGKILEYSDPLVVFVFMMGFVVSTITQCFLISVFFNKANLAAVCGGFIYFVLYLPYTQLVQFEEEIETWHRIVACLSSNIAMGYACSYFSQYEEGAIGAQWSNIGTSPMVDDTFSLEMCISMMYLDAIIYFLIAWYIEAVFPGEYGIPRKPWFFIQKSFWMGTIDRQKQDRMDVEMSVEDFRDNSGNMEKDPTGRKVGVSVRNLRKVYNKGDKVAVDGLSINFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYVYDRNILTHIDEIRSDMGMCPQHNVLFDLLTVEEHIWFYARLKGRSNEEVKRELDQMLNDVGLANKRKATSTNLSGGMKRKLSVAIAFVGGSKTVILDEPTAGVDPYARRSIWELLLKFRKDRTIILSTHHMDEADVLGDRIAIIQHGKLRTVGSSLFLKGRFGSGYYLTLVRQDGGDGSSSAMDSVSMSSRPSTAASVRSVVDVQPRTDTPKIDTTKNGLPSVMNEVEDEGYEEKNASDGSGSDSPIPLPIPKSRLRMVPGFSVSRLTAFIQKFVPSAALVEDNSMEVCFRLPEEEEHSRKFQELFAALEFSHVELGVSSYGISDSSLEEVFLRVAEEGEADENSEEKYQEETTENGRYPRRPSVRSKKPKTSMFKLSYRNRVNSAERLTNDTSDTDNVKKGYESMASEPADSINDINFSGAGKVQVVGKVLVMRQLLALFLKRFHHVRRSKKGFISEILLPAGFVCLAMIFSLILPPFEEEPPLELQPWMYEPKKGDNFLNTFYSQENPTNLLAQSLEATMLNSPYYGTRCMNDSQHSIESKACLPFTSLWTPRPFMPNVSDLPSCSCDSGFQRCPDGAGGPTPSYSVIQTNDRLHNVSDRDVSEWLVRTIDLYRRRRFGGFSLGEENPLGQFNTTQVGEVLERLVTAASNDSSIWAGSEQIWRDLETILEDGYVADNVKVWFNNKGWAASVSYMNAMNNVILRSMLPPGTDSHYYGIVTYNHPMNLTKQQLNEELLYSSAVDVVVAICVIFAMSFVPASFVLFLIEERVSNSKHLQFVSGINPTIYWLANWLWDMLNYSIPAILCIFIFLAFGKDAYVSAKNFPCLLALLFLYGWSITPMMYPFSRVFDVPSSAFVALSCVNVFLGTVSTLATFILELLSQDDPDLKDINVILKQVFLLLPHYCLGRGLIDMASFQLQANVRNRIGQNFNYDPFDWEVVGRNLFAMFMVGIFFNILNWLIEYKFFLSWAFLARKPVKKSNTLDVDVAREKERVLSGGAANDVMRLEGLTKVYSTPGRKGKMTAVDQLYVGVPKGQCFGLLGVNGAGKTTTFKMLTGDEGVTKGDAFINQYSIRSHMVQVRQFMGYCPQFDALDPLLTGREHLEFYARVRGISYREVKSVANWAISRLGLTRYADKISSSYSGGNKRKLSTAIALIGNPPIIFLDEPTTGMDPKARRFLWNCINSIVKAGRSVILTSHSMEECEALCSRLAIMVNGTFKCLGSTQHLKNRFGNGYTIILRVSGENPQMAPVMDYITTTFPTAKLREKHYNMLQYQLGNKNLSLSQLFRAMEEAKRDLGVEDYSVSQTTLDQVFINFAKKQTDLKDDELGEDPADDEEMDENMDDDGNDDNLSAMFNADSVSTGIPSEFDEQSISGSTVELIRPGSRHSHTHIQGKGGASAELSNNEPSPTVMESVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W270</accession>
    <name>A0ABM1W270_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphodiesterase</fullName>
            <ecNumber evidence="4">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035828763.1">
        <property type="nucleotide sequence ID" value="XM_035972870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852283"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013706">
        <property type="entry name" value="PDE1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08499">
        <property type="entry name" value="PDEase_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0140">cGMP</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="6">
        <location>
            <begin position="319"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="692"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="833"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="726"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="908"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828763.1"/>
        </source>
    </evidence>
    <sequence length="929" mass="103130" checksum="401997F933AC98AF" modified="2025-10-08" version="1">MAGNINSPGSKRSPYDLDLLNQLTNNIMKKYGSEFELVSKLTNLKNRPRPKSEQLSSRSVSSLPLVKVTGPDVSDGQGQSMEYLPTRSQSNPCSPRVTRRAFTTCLDGTQYIIVANPPERAKDDSNVGTRNGQLSRTGSLTVLRRTNSRKTGSSSSRASSISIDSIDSYASADLGTDKLPPVDTSEALHACSLRLRNLVRRLEKEELNKDDMRKNLEYAANVLETVYIDETRAKEPSSSSSSTLSHTARRLCEEDDELSEVEPDAVPSEVRDWLALTFTRSMSNMKRKGEDKPRFRSVAHAIRAGIMVDRIYRRMSSSVGLHVPPHVLLLLKNLDDWSFNVFAVNEAADGHALKFVGYELLQKYDLITKFKINTQMLESFLYALETGYSKYKNPYHNLMHGADIAQTVHYVLSQSRLAQWLTDLEVFATLVAALIHDFEHTGTTNNFHINTSSEVALLYNDRAVLENHHISAAFRLVREEEHNILCNLSKEEYREFRSLVIDMVLATDMSFHFQQIKNMKSLLGMPENIEKSKVLSLVLHCADISHPAKDWELHERWTGLLLEEFFRQGDREQELGLPFSPLCDRKNTLVAESQIGFIDFIVDPSYQVMGDMLEKVMSPLHQHPPTASARNIDEAISEEVFEGRDRRDKSTSTTSLCSRPNTPKTPASPYKYELKRPWVDCLSSNKSHWKEKAIKDAEEREKSKQCASEDEPEKPSDSRQPPSPAPRVTTATTANAAPSSPQPAPSSSSSSSPSSPLPPPSSQKPKLSPKPVLPPVRSSSSSTNSHPMVGSVRKGSPQDSNPNPLNSGDKVATTVYVSRQTSTTGLLTNIKLASVDDRKRAGRQKLVTPQGSSVIPLGTTAQGSDSLDDDVFTANRSFPSEEKSRQVADNTTEQKSKRLANLPEVASLSFTDDSGSESRNIGDVKTTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4C2</accession>
    <name>A0ABM1W4C2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101860071</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101860071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829515.1">
        <property type="nucleotide sequence ID" value="XM_035973622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860071"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="240"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035829515.1"/>
        </source>
    </evidence>
    <sequence length="608" mass="66608" checksum="71C7730A5FC8213D" modified="2025-10-08" version="1">MNKGSPDSVLTRKLIEVSRSPVPMMCPVPALVENLYISNYLGKAAVPEGTAAFMCETAGSPWANITLYKEDKPLKTSIGKTRSTASLTLPVQLTCEDSGRYQCHAENGVGPQNLRTQWKTLDVHVKCEETALFCKPRACDDTEMAEGFGSLGKDAIISVCVIAFPEPYEMRLSQNGKAVRLDRYNTRFSYTKQPRGIVTITLKSVTQQDFNSPYKLYIENSDGQYSYTEVKLSPRGPPRCPRSLEVSKVSSNFVTLQWRAGSDRGQKQTFFVLRHSGLNDSHESGRHQEVAASDVTQNSRQAVNVTGLQQKTDYFFSVTARNGFGSAQNCKIVQVSTIAATGAEALSDSEDSTPTVMIVVVVIVILIVIVVAAVVVIVLSRRWRRDRAADRLSQDDPSTYPRDATLVMEPVDDPRRVIGQPTETGNSSGHEYENPYDEVNEMPASDIHTPIPIMSAMAKIAIASPSLSTDHEYEHPYNDATSMLASDIHTHVLIMSTKAEIVTPEAPQANTDTNPYKNVSASAPRSRAGQEGQVRVIDPAGAYDVLAAPDSVAFVSDPYTSLLPERENSQADEVDDSYLNARAGSAEPEGYVNMEGIKKEDDTPYENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBE6</accession>
    <name>A0ABM0JBE6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089778.1">
        <property type="nucleotide sequence ID" value="XM_005089721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854459"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13551">
        <property type="entry name" value="HTH_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089778.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17891" checksum="6844F00194F466B8" modified="2025-10-08" version="1">MPRSTNEERNQVVGMLRANTPVANVARTFNVTRDTIYRLMNRLQTSGSVQDGPRTGRPRATTPAHDWYIRVMYLRDRFRPATKTAREWPGRKTISAPTVRRRLRAQGLIPRRPTRRIRLLPRHRRVRLNWARLHRRWILRQWDNVMFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBL7</accession>
    <name>A0ABM0JBL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein maelstrom homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101847163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the maelstrom family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089929.2">
        <property type="nucleotide sequence ID" value="XM_005089872.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847163"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21992">
        <property type="entry name" value="HMG-box_MAEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024970">
        <property type="entry name" value="Maelstrom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039259">
        <property type="entry name" value="Protein_maelstrom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21358">
        <property type="entry name" value="PROTEIN MAELSTROM HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21358:SF4">
        <property type="entry name" value="PROTEIN MAELSTROM HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13017">
        <property type="entry name" value="Maelstrom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="HMG box" evidence="13">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="11">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="584"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005089929.2"/>
        </source>
    </evidence>
    <sequence length="628" mass="68567" checksum="EC36FEFDD109E227" modified="2025-10-08" version="1">MPPKKAAPNGFYMFMQARQAEIKKQTKRAPTMREMPHICREAWNAMSAEGRAKYEDQAKKAKSSQHSEYSRKDALRQKISDRIDPVKENEKRRLQDNQNMRSDWNGQNLLDIKFHIINFQVMYSNWTVEHRLPMEVGMICITLRDGLIKDMHRFINPGDAPEGYRSMAMQHSEQTHQIPINFEHGDTNFRGLWKQIEQFLADDLEDDDIPPVFCLSSERQDVETCLEYIYDRAATRQPKRVNKVYCLEDMAASLIMLAKPQSAEPSKTQLLDAMQQNRWDYRSDIRCFFHEENDCSHCAISKVRRFSFSLFDMLASVLGFKLTGNHLPDDTATVNTVFHPATIGPSRYRESGYRDREPSSYGGGGDAFSPPRRGRRERSPDSVSKLCPVVSRVQIQLSDEDVARDADSDEEGEDDDDDVLHTQEVKSTADRYQLKELRLPKSVSIAQSGARAPALEEARVGAGDAGVGEMSALSQVPQQPAAGMGVFQHNGLRMGSALAVGRGRPVVNPGAPGLLGGVRPPPGFPALAPGTRGQVPSAWGQVGGGGAAAASAPTGSVWRQGSPAAPSSMAAAAAASHVMGRGAGPTVGRGAAPPPSLSAAGGGVGGRGVLPMGRGRGLPMGRGYAPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEB6</accession>
    <name>A0ABM0JEB6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Craniofacial development protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101861421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091763.2">
        <property type="nucleotide sequence ID" value="XM_005091706.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861421"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091763.2"/>
        </source>
    </evidence>
    <sequence length="248" mass="28429" checksum="A0FEF5E7D42CE8D4" modified="2025-10-08" version="1">MSNELAYTIPERSSPGSPRTAPSAVVHQNGGEKCATDAQKIRARNNISIGTWNVRTLRTAGKLEELTYEMDRYQWAVLGLCEVRWKKFGKITTHEGHKLYLRGEEDKHMNGFGFFIHKDIVNTVMGCRPISRRLITIRLRAVPFNITIIQAYAPTSDYDEQAVEGFYDQIQEVIDQTPIKDTIVVQGDWKAKHHGDGHGTVQVENITTRLTTSRRWTWNSPSGEHHDQIDYITEMDMAQSKWRTSRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEC9</accession>
    <name>A0ABM0JEC9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD repeat-containing protein 75</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101847636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005091786.2">
        <property type="nucleotide sequence ID" value="XM_005091729.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847636"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="323"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="736"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005091786.2"/>
        </source>
    </evidence>
    <sequence length="805" mass="89513" checksum="209E41192CEAC97E" modified="2025-10-08" version="1">MDLVPCLQAGSRFGKLCFSHDSRYLFCCCGSVVKVFNTTNGECVHDLTAHSKAVTGVFLNPSNVLQIVTCGQDGCLIFWDYLDGVKLKEHDLHMPLYGIVSVNADTKSMMIIAETSAHKKTYCLMQWKRSKTNPNEFSKPKMLIENCAGDYGLISFGCSREFVASASGHMLTIYSMKKESKRITPNGTLSPDPAGPQTPIRVFLTFQLQLVEALEKEKSPIKTPYYFFSGIVGSNLLSGGHECVLVKWQMSNTNLKDFKPRMGAPLTKILCSPDGTFYATEHSDNAVQLSNISMKVLQVYRGLTRGNMGLSSDKNPIPCGLKFDHRSQALVTNGLPGHLQFYSLALNRQLFNLDIVGQNYISPENIERPKVVTEVIAAAVSGSGEWLATFESWDDGLFTPELRLKFWSWSTEAQTYSLNTTVEGPHDGKVKRMIFRPQSELNLSLVTIGSDCCFKLWTLVDDTDIYRSNVRWDCESVGFYRGMEVSCADFSQDATALAVGFEHLVTLWDPDNNIVQATVSNSLPEREPISHILFGNKQCSHLLVVATTKTLLVWDLLTLTVQWKLPSANITSLFRDPASDLMAFVSAGASLNVFSPRNSTMIYQHENVSRSCVLDALFIPDGRHRGIAGVGWPGTSQIYIFNADEELLTLDYPKQQKSSETQVKISQNLPQSAVSAFLAEKMVRETGDSRDKIPLSSRNQVDDSFISVLLHSNEPVSLHCDQYLKNLLVKSSAMSSSTIDTGDDDIDEDDRDDSSESEMETDEKGSALPALDTTDGDQIQEEEDMNKLLSPSLDWIQWCAKLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFP2</accession>
    <name>A0ABM0JFP2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Dentin sialophosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6" type="primary">LOC101853066</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092603.1">
        <property type="nucleotide sequence ID" value="XM_005092546.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005092604.1">
        <property type="nucleotide sequence ID" value="XM_005092547.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005092605.1">
        <property type="nucleotide sequence ID" value="XM_005092548.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005092606.1">
        <property type="nucleotide sequence ID" value="XM_005092549.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853066"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005092604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005092605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005092606.1"/>
        </source>
    </evidence>
    <sequence length="710" mass="77895" checksum="998E52A1A70F1DD2" modified="2025-10-08" version="1">MMDRQPGQNAEPPESLNSLEFPPLPSRSDTVHLVPQTVAASQGSMSQKNQGVKRTICDDGSDSMKEESFLSSSNNSGSHGSSSPPSRKSRRMAYRDVNLPSLDSDTLHSMFSSPTFGDSQNSLSSTAFRSSMAVSPNDSLGSLGDIISRYNNATLDSMKGFEISFSCDSDNANTSPVLLSPTSKGNSSSDFSVSSMPSISKSLSKPLAQEDSSDSGNVLFESKRSFEYYENVQITSAASVESDFTSSGELQCKAVTLSAGSSCKSSLDVKIPESRETKSKKADDLHQQQYLSHGSKKDRKVAGCLQKGKGSGKFTVDSTRVKDTSDDDYDCEDAGDFCDAIHMSECNTDILQNLKKCKKNPKHEKFFLTSDLKVRDLPREIQHEDSLTFLNCMSQLVVQITVHSTSSGRDSDDVYRSYIGTDRKRHGSGFIASVDESIQRFRCRKEDCLECCLNMSSDSNTPYSPPITDIAPSFDRSVSTISTASSSSASSSGGSSQKHYFYGGLNIRTNRHVIFDKSEADNAYVKFFFNTPDGKGVVHGHVGSIIGVNTCQDHIILHVMSHKKSLFHYAETCLKNARSSYNQMVCSTIKTQETLAPKLLQSWVAVISHPHGLAKHISIGHVCQEKVEARRVIKYYNAATCPGSSGGLVITPTLLKLQWPGAVHSLYDKHTRFNVTLDSRFPDLDNTDMGRLHKTIVCRKDSFPDNYFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG31</accession>
    <name>A0ABM0JG31_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat, PH and SEC7 domain containing protein secG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101857775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092878.2">
        <property type="nucleotide sequence ID" value="XM_005092821.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857775"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="469"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005092878.2"/>
        </source>
    </evidence>
    <sequence length="537" mass="58489" checksum="D93A63DEDC4B804B" modified="2025-10-08" version="1">MEFGSAGDDVNEFTKLFVAALDSDNMTVVESMIRTKVKDFRFPLDMSQCAIMASARGNSDVLSRLLPLHPRMSYSDSAGRRAIHYAAKNGHLTCVELLLKAGAISNCADGTGFTPLHLACDNGHVDIVSLLVRQCAHINSCRTELGESAVHAAAKAGHVQVMEQLLAYGADLNATARRNKGGETPLHKAVAADKPEMVEFLLQNGAVASIADAYGKSPVHIACERGLLRCLGVLLQREVSLEVRDNIGQTALGSAIMENQTEVAKLLIEQGADVHSVDQNGYSLLHKATMRGNLELMECLVASGSDVNVRTPANLQSPLFTAVSLGKLRAVQRLVDLGADVTLPDVKGHTALHMAQAKIGGDPVEEIILALLKAGGRLDVRDEGHCTPLQRCIIIGVIRRNVSLPCLRLFCQAGSALGPDEFTMGKKSPLFWLAYSGFLPEALYLVRAGWNLGEEIWIVLPGKDERQDRLHEYMVQSYRTVPSLLASCRKTVRTHLSEMRQHREILSSIEQLPIPVPLKNFLLLLDIDANDHRALEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JH97</accession>
    <name>A0ABM0JH97_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101851021 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101851021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093631.1">
        <property type="nucleotide sequence ID" value="XM_005093574.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851021"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FDX-ACB" evidence="1">
        <location>
            <begin position="658"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005093631.1"/>
        </source>
    </evidence>
    <sequence length="763" mass="84186" checksum="489FC821F64973A6" modified="2025-10-08" version="1">MDSACHGRVLLVGDGDFSFTVSLLKLSTLQPSQVISSNIETPATIQQHKLASDNMKAIQDLGGLVLLETDARELHTHPIISQYKYARIIFNFPLADRHNIKKNRALLADFFASCASILSEDGQIMVTLCKGQGGTPADNPMRSWHDSWQVVAMATNSGFLLTDVMLFDATKYPEYHSVGFRFQDKSFNTGGGLTHVFERAPLVEVGEAVARTSILCGDVAYSCSSYIADRRKRNLLHEANNPVSLVCRVLKQTVSQNLELDCKDVEDDFLFVKGHRSRAVVNLCQPCAGSSTLTGSSARQLDVDDEGTVEQKTVKEKKEEFNVTLQNKEKLSSNTLAHGIVQDKTTPTERLHEHHDDVSTTFSQLGLILPSEPEAVYSAIKRTPKSCQGADGDSACQEGVHELSGDAEMKSETLEEDPSQRVFHLRTSLLEVAGDLWSHSVADSSSVGTASSVLGTDGSVGQGRGKCVAFTGQCYQPCDVRPGHLPVTHELLMIHGPGGVVERSTLFDSPKDSSCTDGHSSPPNETLATYSSFDKDKLIPDSVLSKVIAACNTSSLCSDWCFEVRPADQTCEVLIESLDSVTDLKTVQLRRQCREDDTEKFDKTVCTVGLLCSADVCGQKCEICLLSLDNIAGAVCSLPNSRLLWSLRDKFTQQFHASGFPHVYQPFSLFPMKLVHDLSFWLKDSEETVDEYELADAVRCVAGDFVVRVQLIDTYQDQESGQRSRCYRLHFLSHDQALPYLTSWKLQSLIRMEVARRMGVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIV3</accession>
    <name>A0ABM0JIV3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Ultraviolet-B receptor UVR8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101846803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094677.1">
        <property type="nucleotide sequence ID" value="XM_005094620.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094678.1">
        <property type="nucleotide sequence ID" value="XM_005094621.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846803"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="131"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="205"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="261"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="315"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005094678.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="39314" checksum="568B2442B0903296" modified="2025-10-08" version="1">MALYTWGLGSNGQLGTGNLETKHTPQNIKPPGKVKQVDCGALFTVVLTEDGAVYSTGCGKFGRLGHGSSEKDSNILGPVVLSVKCSQVSCGSWHVGVVTTEGALFLWGYQKAFVKVLKPENMGLPNLFALPHKAKVAGVSCGHNYTYAWTVEGQLYSWGRGQNGVLGLGSDDDQRLPQHVETLKEEKVATVGAGNSHCGIVTESGLLYMTGKGSDGALGFGHSHLGNALLPKRCETGTEVKAVSCSKGEHHGHTLALTVSGSVLAWGDGYKGKLGLGGQESRYTPAVIPPELFNNQPVTSISAGGIHSAAATASGEVFTWGCGSDGRLGHPEGQGHRYLFRSDIPKKVEGLPKAGAGKVTVSCAYYHCAAVVHNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKF1</accession>
    <name>A0ABM0JKF1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrinogen C domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095801.1">
        <property type="nucleotide sequence ID" value="XM_005095744.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847813"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046096427" evidence="1">
        <location>
            <begin position="24"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="250"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095801.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51006" checksum="82A077AF260DE163" modified="2025-10-08" version="1">MDAVRTFIPKLILAAALVMSSRAWRLNVTSSEIDVGRTAQVSLNCFNPYQQQDITDLLMMRIEKKQLTGWSSVAELRHGDVDVRLTANDVTATGNIVSGANSFMQLTWPLATNGTIGLYRCDVTFLNSHGSVGWQKGLPTSISRKSDVTVQILSEMVDETKRQCTQQKQDIQAYVAAAVEENKRHCLKEKQDVLQNMTAMLKALEILVTVTAALEMNQREVRQHSQRLLANTSAAMGEVQASLEQRLSDVEDKLWPQSCASVKGLGPRPVVLLSSGQRVVCDTVTDQGGWIVIQRRASADVDFSRGWEDYKNGFGDLYGNFWLGLEKIHQLTSQVRHELRFDLRFQGKNYFASYDKFLLSGETDNYRIQISGFSGNVSNDMANHNGQSFSTKDSDNDSSSTNCASRYHGAWWYNNCHTVNLNGLWGSTKNAKGLRWRSVTTGSVSFSEMKIRPFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKJ3</accession>
    <name>A0ABM0JKJ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylglutaconyl-CoA hydratase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101845231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095876.1">
        <property type="nucleotide sequence ID" value="XM_005095819.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845231"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005095876.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="33714" checksum="BFB7CD01EC2AC90D" modified="2025-10-08" version="1">MAVHSVKRLLLACVFRTGPIKLGSRCLSSSTTTTTQFEAAPSVADEVKVDHLDGDQKGIAVLSLRRFRYKNAMGKNFLIRISDAVEEMRFNNDIRCVVVRSEVPGVFCAGADLKERLQMTDKEVAEFVNTHIRENITRLQNLPMPTIAAIDGAALGGGLELALGCDLRVASSNAKIGLIETSLAIFPGGGGTQRLPRTVGVALAKELIFTSRVLDGVQAKEHGIVNHCVEQNDNGDAAYLRALQLAEEILPNGPIGVRMAKAAISKGSQVDLESGLKFEEAYYAQIIPTKDRIEGLKAFKEKRRPKYEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKQ1</accession>
    <name>A0ABM0JKQ1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-processing factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PRP6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">U5 snRNP-associated 102 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101855246</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005095991.2">
        <property type="nucleotide sequence ID" value="XM_005095934.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855246"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="12">
        <location>
            <begin position="41"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="126"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005095991.2"/>
        </source>
    </evidence>
    <sequence length="944" mass="106942" checksum="4607A71F3782D469" modified="2025-10-08" version="1">MNLSADQFLPSLLCALPLRSNINMSVQFVNKRKKTFIGLPAPLGYVPGLGRGATGFTTRSDIGPARDADDIPEDRHAPPNKKSKQDKEDDEEDLNEANFDEFTGYGGSLCSKDPYDKDDEEADAIYEAVDKRMDEKRKERREEKLKFDIEKFRQERPKIQQQFSDLKRNLSGVSVDEWNNLPEVGDARNRKQRIGRTEKFTPVPDSVLAGAAARNSMNSSISEQDQKYGGLTTPFGAITPLGSATPSADIDMKKIGQARNTLMDIKLTQVSDSVSGQTVVDPKGYLTDLQSMLPSHGGDINDVKKARLLLKSVRETNPKHPPAWIASARLEEVTGKVQAARNLRQPDLWXVCVCVYPGDQAKAVVAQAVRQLPQSVRIWSKAADLEMELKAKKRVFRKALENIPNSVRLWKQAVELEDEEDARIMLSRAVECCPTSVELWLALARLESYENARKVLNKARESIPTDRQVWITAAKLEEANGNSHMVEKIIERAVNSLRANMVEINRDQWIKDAEDCEKSGSIHTCQAIIRAVISVGIEEEDRKHTWMEDSDSCAARQAYECARAIYAFALSEFPSKKSIWLSAAYFEKNHGSRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENNEYERARRLLQKARASAPTARVFMKSVKLEWCLGEIRNAEILLEEAVKHYPDFAKLWMMKGQIQEEAGKKDTARESYNQGLKKCPQAVPLWLLLSRLEESQGQLTRARSILEKARLKNPHNDELWLEAVRVEIRGGLKSFANTQMAKALQECPNSGILWAEAIFLEHRPQRKTKCVDALRKCEHNQHVLLAASKLFWSERKISKAREWFNRTVKIDPDLGDAWAFFYKFELTHGEERHQEDVRQRCLLAEPHHGEHWCSVSKDIKNWRLKTEELLPLVSKSLQVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKU8</accession>
    <name>A0ABM0JKU8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine 5'-monophosphate synthase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
            <ecNumber evidence="6">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101854248</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EC" id="4.1.1.23" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005096073.2">
        <property type="nucleotide sequence ID" value="XM_005096016.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854248"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010382">
        <property type="entry name" value="PRK13809.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="14">
        <location>
            <begin position="251"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005096073.2"/>
        </source>
    </evidence>
    <sequence length="477" mass="51750" checksum="0CA65C1BD265A955" modified="2025-10-08" version="1">MAASIMSCSPATTESLIIQLHSIDAVKFGDFTLKSGIQSPVYFDLRVMISHPKVMVDVANLLWGKISSCNFKSLCGVPYTALPIATLMSASHDVPMLIRRKEAKGYGTKKLIEGTFSEGDVCMIVEDVVSSGSSVLETAESLQAAGIRVTDAVVLLNREQGGPEKLAANNIKLHSIFTMNDVLSVLSSAGKMSPEMVDRVTKYIAENKFKPDQQVPSAVKPKVLTYAERASQCTHSVSRRLLKIMEQKKTNLVLSADVTKSKELLDLVDKTGPHICMVKTHADTLDDFCDDFVEKLKQLSNKHNFLIFEDRKFADIGNTVVHQFSGGVHRISDWADVINAHTVPGAGVVQGLQKVAQGKDIGCLLIAEMSSAGNLATGDYTQVTVKIAEENPDFVIGFICLSKLSSNPALLHMTPGVQLKEGQDALGQRYLTPQEVISNRGSDIIIVGRGIYGASDPTEAARQFQIAGYDAYLARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JL03</accession>
    <name>A0ABM0JL03_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101856336 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0046 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096169.1">
        <property type="nucleotide sequence ID" value="XM_005096112.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856336"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096169.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39273" checksum="AD00567275141308" modified="2025-10-08" version="1">MRPEIEKILPSEMNDDVMSIGNVNCPNSATKIVRIVHISDTHHAHNTLTPLRPLSGNIAILRSTSIDSPNQIIDETGADAFARSASARLQMQASESNDSSFHKGGTFLSSFRRSHSSSTSVPPGDVLIHSGDFAWNSKAPGLFRSENFEEIIQAMNDFFDRFPHKVKIFVAGNHEASLEGKKLLSVQERLTSAVYLYNSSYTYEGIHFYGAPYTPFRLTTNATGFQRHSRSIAAHWREIPSRTDVLITHTPPHGILDLATDFTARKVPKLSSAIHRLLPKGPCSTCGIIHPGRSHWGCRHLREEVLIRIKPKLHLFGHVHECNGITTKNGVTFSNAAYKLSKQHHVFDYYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLB7</accession>
    <name>A0ABM0JLB7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynein assembly factor with WDR repeat domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096405.1">
        <property type="nucleotide sequence ID" value="XM_005096348.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850556"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF744">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR WITH WD REPEATS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005096405.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46307" checksum="8CFB960F5D7A95AB" modified="2025-10-08" version="1">MKLKRFLLRYYPPGIILEYEQGGILKTKSIDLLDLSPTTEIDKVVEEITEKEPLITPSKVDQVKKLIVRLQEKIAQRDDHHFYLFKVLRAHILPLTNVAFNKSGSSFITGSYDRTCKVWDTSSGEEVHTLDGHRNVVYAISFNNPYGDKIVTGSFDKTCRIWSFDSGKCYNVYKGHTAEIVCVSFNPQSTLIATGSMDTTCRLWDVEKGTEVATFQGHTGEIISLSFSSTGTEVITASFDHTVSLWDVRSNKRIHTLIGHKAEISSAQFNFDCSLIATGSMDNTCKLWDRASGRCISTLRGHSDEILDVGFDCIGQRVITASADNTAICYSAVTNQQLSKFVGHEGEISKITFNPQGTLVMTASADKTARLWDPETGNCRQILEGHTDEIFSCAFNYEGNTIITGSKDNTCRVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLE6</accession>
    <name>A0ABM0JLE6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="13">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101860887</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="13"/>
    <dbReference type="RefSeq" id="XP_005096448.1">
        <property type="nucleotide sequence ID" value="XM_005096391.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860887"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07541">
        <property type="entry name" value="P-type_ATPase_APLT_Neo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="906"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="934"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1010"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1072"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="107"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="199"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="16">
        <location>
            <begin position="872"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005096448.1"/>
        </source>
    </evidence>
    <sequence length="1107" mass="125474" checksum="EF4CC1ADA2289ACA" modified="2025-10-08" version="1">MPMTNRVNYTTSLTVSKRPRAVSSDDEDDHGACLDTVPLMCGDSFEMDESDRLVNERRRRYRTRGFFSFLSQRWSSFCSNCWGRVFSVCCREKELRPRTVHIGLGTHQTEKHPRNVVRNQKYSIITFIPKVLFEQFKFFLNLYFLIIALSQFIPELRIGYLYTYWGPLAFVLFVTMSREALDDYRRYRRDKEANSQKFKKLTRDGIIRVPSSDIQVGHLVILEKNQRVPADMVLLRTSEKDGGCFIRTDQLDGETDWKLRLAVQDTHRLPSNVDILDITANVYAEKPQKDIHSFVGTFTRSDTGSEHEDSLSIENTLWANTVVASGTALGVVIYTGSETRSVMNTSQPKSKIGLLDLEINTLTKLLFFAVLVLSLVMVTLKGFGGPWYRYFFRFVLLFSYIIPISLRMNLDMGKAFYSWVIQRDKTIPGTTARSTTIPEELGRITYLLSDKTGTLTQNEMVFKRLHLGTVSFTPETMDEVVSHLKTSYSTPSTTNATPVRSSGPVRRSVLTRVVEAVRAIALCHNVTPVYEESSNGDVKSDDTEADQQLKQRVSYQASSPDEIALVTWSESVNLTLVKRDLNSITLRTPTGALASYSILQIFPFTSESKRMGIILKDKESGEITFYLKGADVVMQSIVQYNDWLEEECGNMAREGLRTLVVAKKVLSEEQYQEFDSRYHQAKMSIQERNSKMQAVVEGLERDMELLCLTGVEDKLQEGVRPTLEMLRNAGIRVWMLTGDKLETAICIAKSSKMVSRLQDIYVFQSVNDRSEAHLELNSLRRKNEAALIISGDSLQVCLKFYEHEFVELACQCPAVVVCRCSPTQKADIVKLLQTHTGKRTSAVGDGGNDVSMIQAADAGIGIVGKEGKQASLAADFSISQFSHIGRLLLVHGRNSYKRSASLSQFVIHRGLIITTMQAVFCSVFYFVSIALFPGFLMVGYATVYTMFPVFSLVLDKDVSADIAITYPELYKDLTKGRSLSFKTFFLWVLISLYQGGIIMYGALLLFEAEFIHVVSITFTSLILTELLMVGLTVRTWHYLMVLAQLLSLAIYIVSLAVLKDYFDNQFLRTWDFVWKVLVITSISCIPLYVLKYLRKKFSPPVYSKLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM73</accession>
    <name>A0ABM0JM73_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cartilage matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096970.3">
        <property type="nucleotide sequence ID" value="XM_005096913.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863977"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01472">
        <property type="entry name" value="vWA_collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047079138" evidence="2">
        <location>
            <begin position="23"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="31"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="247"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="456"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005096970.3"/>
        </source>
    </evidence>
    <sequence length="702" mass="77464" checksum="200E3616B46F20C1" modified="2025-10-08" version="1">MHPFKIVLLVALAIANIKTSSANIACDQTADIVFLVDTSSSIYPGDFNLHVKKFINDVVGSFNVGPGPLDTRVGMVLFSTRAHLQFYLRSYKTAEQVQAAVNRTRFRGGDTYTHKALAFTSRIMLKEYYGAREDVSKLVVVLTDGKSIDEKRTLQEAQKLKDAGVEIFAVGVGEATDFNELSSMASSPSDQFAFRVTDFKALDSIKNSFTRSTCQGRYQRLKDIHVDTRTKQLSFCIFSGCKGKPADIYFLLDASSSVYVVHFQDRVLPFVRDLVSSFKISPLHTRVGLVTFSNEVDHVFGLSSHADLDSLKKAIQPDTVEYLTGGTNTGDAISYVTKTAFRSGEARKGVAQIIITVTDGLSQSPRRTAKAAAEARKEGIYMFAVGIGNFTDDQELMDISSNPDEDFVFSVDDFNALGSITNLLAQKTCKAVAKGDKDDNEPKPNDQAECSSQPTNVVFTYSYMNSISASRTIVQDVITEFVRDVQMQAPHVKIGVVTQPCVSGTDSLVAVSRFQRALAQIRSNYYIGYPGIIRRLRVEVFSRVPLTDNRIAVMFVDENTKNLDLLQEEVRKMKFKNVKVIVVAVGKLDNSVLKSLASFHHSVNVFHVDSYDTLKEQKLNLLGSICKQQKVDSSSSSSNSGASTIVKVENHTNIYPSYVHGKIYGTGSNGKGPGKNSDDKPRDDKKESVESTTAWNFFPQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNT0</accession>
    <name>A0ABM0JNT0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Cysteinyl leukotriene receptor 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC101847820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098018.1">
        <property type="nucleotide sequence ID" value="XM_005097961.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825572.1">
        <property type="nucleotide sequence ID" value="XM_035969679.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825573.1">
        <property type="nucleotide sequence ID" value="XM_035969680.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847820"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="115"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005098018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035825572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035825573.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="51972" checksum="9FE2D27EDFF2C396" modified="2025-10-08" version="1">MSSSSFRLVPGHSSGGLMVSVKDLCLFLKYRVMGLDICNESTSLNSSMCATVEENRELYKLLGLLAEHPDLQMNATNCSTLSKIEEDHTKVTALVVGSLFYAYFTPFVFVTGILGNSVSLSVFLCKSMRHLSASTYLAALSTSDLMVLIFYVLTEWLIRGVPVLSPDTKVTFMHVNGACQVIMYFHYVSRFLSAWLVVAFTVERYIGVCHPLHRRHICSPTSTKKIVFGFTVFSLVINIFKPLLSVVHDVELWGPMCTTYPQHRQLSFVLDSIYAVFITFIPFVIITVINILIIRRLVKHNRQQRLVRVVTEESVLRLEFTSILLVVSFCFVALNLPYFAIWCKLFLTSRFVNVQTFEDPDELDYFRGLALITRAIFCMNYCINFFLYSITGAYFRRQLRALFHYRSARYKQHSPCQGYCMHGSLQNSDSHSKNSLRRESVKSLRMTSTPQTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNW1</accession>
    <name>A0ABM0JNW1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein SERAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine active site-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101862033</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SERAC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098079.1">
        <property type="nucleotide sequence ID" value="XM_005098022.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862033"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005098079.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="67712" checksum="D7C15DE9C931987E" modified="2025-10-08" version="1">MQNLSLHQSAVVEPENCRYRKWRAQLGKMFQPTEPVAAFTDFEEWFTFQYVSFTSARDVPWGDESEAGQEKHFLGWLFPWELSKSDNPWVLLQLTKSTNFWIRQMGVASLASKLHWEDYKYRGIAQACEPRTTVALARYPSAKDAFFLPPPRLHDSQRDVLLDLKHQLSQLPVPNFASSISYFRTIALDPEIMFQRDPVTMDMDVITHMYTLPGEDEKKRERKLTFCLEAVLAYTAVQEYALQFVENHGLSVLQRLQQVITDSWVQIYIASILANLSQCPSLLDIIVQTGWVYILRQWAASEDAFLSLLALTTLANLDQDWTSHDFFQDMILIHPTQRNSKPAKADIVFVHGLRGGAVRTWRQKDNDEGITSQCWPKDWLAADCPHIRILSIGYNSSLHRWGDYCPFEQDKRTLEGRGHELMKKLKQAGVGSRPIIWVGHSMGGLLIKQILALSGEDQESSDLKSNTKGIVMYSVPHHGSAIVDAMMYAKYLLFPSVEVQELLTTSPRLSDLHDQFLNFMTTHSVPLLSFGENAKTAVGRPLPKLLVVPPGSSDPGFGKFVSLPVNHINTCKPHSENDISYQLTVAFIKGVIDRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNZ8</accession>
    <name>A0ABM0JNZ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM227A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM227 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098145.2">
        <property type="nucleotide sequence ID" value="XM_005098088.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856892"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029417">
        <property type="entry name" value="FAM227"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33560:SF1">
        <property type="entry name" value="PROTEIN FAM227A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33560">
        <property type="entry name" value="PROTEIN FAM227B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14922">
        <property type="entry name" value="FWWh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098145.2"/>
        </source>
    </evidence>
    <sequence length="635" mass="72049" checksum="AD852A1A5B05DD64" modified="2025-10-08" version="1">MSGINRVGSPMDLLDESLDEAPDKVSLRKRLLEAKQRTKSPFLIGSIEEVNKKISRLDHKLQSYTELICESRASAYDNDGPMPSSARGRDQYQKREKETKEVCKFAGVYTLKSTFVPNLSTRVKNISKISMKPKKAKAPVAKKGDGSKPKFVELHQYPGYDPSELTPLPGGLSASEIFDKVVKASVLLNRKPHYKPEFERLFYSQMSQAVLLDIFWYIFVEKFQPNTITQAKLFNRVAHNYVKLMMYNSDLFSKDTFFKDYPKLMSQAVYASFCFAFPDSYRQFGEVFKDELIFLVYEWMAGIRPAPRSWMSWDMSNLEPPNIKLREEMMNRKNSKKASSLIDFDYLDSLISTNASQYASTMSLAQSTSKSSANSNLGPRKTRMHARISKVTHKPMIRSSSPNKSQSPTLSQDSNVIDAVADAQGSPRVRGVNREGKDTKRASEALTPIREMTSEDEADTLGKKISQLSVSQTRDSKTVGKDEMESHPVGRGCDFVRSAFNVEGKSPLVAHFLSMKGLRRDAGQLVWMQRVEVENLPSLDAPTYKDLITDSSKTIKKIEKNYQDMYQRTQQESQVFVRRRQDWLWEHTRKQSALLANQKEVKRLSDLLILEQRKGPDSISVGASAAVEAALMAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ11</accession>
    <name>A0ABM0JQ11_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101860815</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098849.1">
        <property type="nucleotide sequence ID" value="XM_005098792.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860815"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098849.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="18020" checksum="D3E1C6A168E6E6C0" modified="2025-10-08" version="1">MAYVDGVISLRRQQTRTSVPHCIRLLPENRPQNRAEALAYRLLWPDDPRAYLDHEGRYLYDTRPLAMRLEDAKKDRWRRLQDIQDKLEIVKTLMGAEDDQRPPCVVDFDVMRHRMTKAHKKTARENRGERKTSQPTRTRKIHHYDKTTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ82</accession>
    <name>A0ABM0JQ82_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyadenylate-binding protein 2-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101853939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098989.1">
        <property type="nucleotide sequence ID" value="XM_005098932.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853939"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12550">
        <property type="entry name" value="RRM_II_PABPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="95"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005098989.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24555" checksum="6968BE938044D8C6" modified="2025-10-08" version="1">MADTENGENETHDEESSMLTQGSAGDATNITEDSGVEDPELEAIKARVREMEEEAEKLKEMQTEVDKQMNMSSPTAAPTASPFPTPEEKLEADQKSIYVGNVDYGATAEELEQHFHGCGSVNRVTILCDKFSGHPKGFAYIEFADKDSVITAMALDESLFRGRQIKVVPKRTNRPGISSTNRRPRGRGVSRGGRGQYYGGFTPRGRRPYGRFRRAAYYSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQF3</accession>
    <name>A0ABM0JQF3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Nestin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11" type="primary">LOC101864226</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099118.1">
        <property type="nucleotide sequence ID" value="XM_005099061.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099119.1">
        <property type="nucleotide sequence ID" value="XM_005099062.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099120.1">
        <property type="nucleotide sequence ID" value="XM_005099063.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012938404.1">
        <property type="nucleotide sequence ID" value="XM_013082950.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864226"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF12">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="100"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="752"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="936"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="998"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1205"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1345"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1584"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1679"/>
            <end position="1834"/>
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    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="90"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="365"/>
            <end position="431"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
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        <location>
            <begin position="569"/>
            <end position="579"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
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        <location>
            <begin position="852"/>
            <end position="865"/>
        </location>
    </feature>
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        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
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        <location>
            <begin position="1010"/>
            <end position="1021"/>
        </location>
    </feature>
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        <location>
            <begin position="1136"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1226"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1250"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1345"/>
            <end position="1373"/>
        </location>
    </feature>
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        <location>
            <begin position="1386"/>
            <end position="1397"/>
        </location>
    </feature>
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        <location>
            <begin position="1398"/>
            <end position="1414"/>
        </location>
    </feature>
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        <location>
            <begin position="1422"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1455"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1584"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1594"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1626"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1750"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1776"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1806"/>
            <end position="1819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005099118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005099119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005099120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012938404.1"/>
        </source>
    </evidence>
    <sequence length="1834" mass="198649" checksum="7A41A6B0C1A4A5F1" modified="2025-10-08" version="1">MSQSFIRSSTTIPGNTSVTEKRTVITSSSSSGSALGGLDDDSIYYKSSITPRASSIMRTSMPTSPIRTTRTVEMSSGFIPHTANVTATGVNSFKSNREREKKDLQDLNERFANYIEKVRFLEAQNKKLASELEQLRSHWGKETSAVKQMYETELEEARKLIDETNKEKARLQLRVGQLEEQLDDFQRQLDEAKKWRSQDRETINKLNQQVSELEGEIRMLRRTNDSLDTERARDKATIARLQEELEKLRIDLSNETIGRLDAENKYQTLLEEIEFLKSVHEQELKELSALAYRDTTAENREFWKNELSQAIRDIQQEYDIKVDQIRGEMETFYNLKVQEFRTGATKQNMEVTHAREETKKLHKQLADSRGRLSDLEARNAQLEKQYQELLRELEQKDSEHDLEINSLKEEMNKLRAEMEGMLVELQTLMDAKLSLELEIAAYRKLLEGEETRIPLRNSFWSAYTPYSDSSHKSEPISAPYRPSSSSSKTSFSRPSVRDTSRTTSTPRGHDVRIKAARAPVVESVTSVQKATTSYEAPPTIVEPEEEVIVKEEAETALRCEAPSPAPAVQDDEQKEEEENSAQVEMVDTRNEISGDVSQGDTQDDGSGKVVIEASDIKQEIVCQDPSYAEETHESTTIEQLVTHSGDVMSHDEVTEGDGAKREVEDRTYDQPEVGDAGDGKQKVTEEQEEEVARSTEDTSGVKVGVDSFTEILTAAVQDAVVKEISASEKAETEKIEQVEVVEEAIVRSEIVEIPEAAPAKDSGRDDVGSMAPRQNEAEAGEGGVGEEGEAEGERVIECARGAEGQEAEAPIVLDPQIQANDQVGQGPEQVEISRNEAQGEGDAAAALVSSGGDDDEKSGQTEDDVLVCAPKEQKTDTDCKAAEDAAGEDDSESTVASLETSQTEVFVTTQAAPETAEVVSDTVTEKEDVEPTQAAALLISKDSTTDTTHVTEDISVKSQSTEPHEEDESKAVERKVEEDVIISKTFSMSESSAKFLSEVPVGSDSGEGGAAAAEVPGDVAGQNGMVVEQKDDHFRTETVVERKEVTVSTGSSDVVVQAPICPKEEDELEEESVLVNGVKDDLMDASSPDVSAVDHFRADFSMATPVPGAEKGTLDDTDDDALNDDYMGGGVEGGDTDDKGVRSSGEARVDEQSTEGVKVEGLVTTTSVTAADSTDSSESVVVVDANANPAVGQTDGDIVTVVEKKEASDDTSVVTAEVEANATEDSNEKDKQHEAMAEETSGGDGVSTEKTAEVERTETTTVYHEVRSEGVQKFTTSTVETESEKMVFDGGADAADIKVEEVKVEPHQEPQTSIQGIDTILHQGSVVTSQSETDGKGIVVEEKQETFSSFSKHESSSITVEETKSVVDQEVSKAGEIASDAKVLKSVSTTETHFEVNTSTGKTDSGLTSSGTTSKTDEEEMSQGQGDTQENTQEFTSTDAGVPDLEKDAEESVASGISETTEKTTLTSVQMSQQESPALSQAEKDDVVQSVAGEKIYDAAAGLQLNEQVETSSVTVEKHVLEETVDGSRAGNILEAEESLTEKSIAIDNAEIREGSTQVNDNTTVTESTSVSFGQVADNTDEVKVKDGKDESQKTLGISSGTIKESSTSEVKTEVTDEGDGVSVEKTAEVKRSETKVVSHEVTDEGMQKVTTTEEHSSVEVVHTKSGTVTETSFSTVSVQESSTKDAISFGTQGLDETDKEKEDVDVLVQGSVAKDGYEEGDDDTTSIDSQGGTGELQVATVDLKDSTASDKSSGTMLASSSDELPKGQPDAILETQVNQPGLASGTLSLATEKTENKDGSDVAESGTTSQESNVTPRESTSEEENVGSIKSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQJ9</accession>
    <name>A0ABM0JQJ9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Forkhead box protein N3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101846815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005099217.1">
        <property type="nucleotide sequence ID" value="XM_005099160.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846815"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20059">
        <property type="entry name" value="FH_FOXN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047404">
        <property type="entry name" value="FH_FOXN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047119">
        <property type="entry name" value="FOXN2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13962:SF22">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13962">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N3-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="10">
        <location>
            <begin position="167"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="8">
        <location>
            <begin position="167"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="796"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="848"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005099217.1"/>
        </source>
    </evidence>
    <sequence length="863" mass="94136" checksum="D14164CE9C17449D" modified="2025-10-08" version="1">MKMADSGCEDTVPSMAPVCKLPEESDASMRARLFTSLSQSFPHSQLYKALHGGGDMILNGGDGGGLSDDDDDSLYGDHLSNSCFASLRMDRRDSDDFDDDLRSLEWLQSEDLLKNIGGEKLDKDEDGEEQKENEDVKPDINLLQAGHAPGQQPNNLPYMPQKHVNSKPPYSFSCLIFMAVENSPKKMLPVKDIYNWILKQFPYFQNAPTGWKNSVRHNLSLNKCFKKVEKDKGQSIGKGSLWCIDPAYRPNLLQALRKTPYHPYHQLQMTSTQPPSYINMQYQSLPGGGRTVLPLTQRPIPNTVSPHLFPFLSRRLAQTSFDVDNEMKDVAQTLVALKGSYKKESPDSSPGEDIGPTWKYHKRSYSYNNPRKRPSSPVVVTGHPYDDHAYSSTRLLEDDLPSPSSSSSIDEEYDFGDADEEGESDYQSDSDWDSDDKDEVDGVLPSTKKLKIDMDRDNSGSASKPSAPNDSEDDEQKKIQEGANALLNLAGLLMSNRSSSSTSNSNSVDGREVREEAKSKRKAGDKKKVRKKQLPQSEKKREPKEKEEGSQRKRGFSKRKNAGSNGKYDSEEYSLLKPRKNTKTKGTAGVAAKPLKSGVSKSSAEKDSSFSSNSAAKSKAPPGRPKGLKKAGVVKKKLKLSKSFGTKKNIIAGKSETALDSKTQKKRVTSAGEKKCVTKTKLKSSTAEKGNKDTEENMVVTQDVFSSSSNANNLNNNNNVVKDDSSPNELLSNNVQLNKPKSPSPEQILKEPVGLIADSQPSLSSLSSVSGEELTPAGDAPVKSACRSLAGDFSAAANEKVSSAPTDTCSSLLEETVLPSSKTSSSKSGLSGRSTPVSSAGSPGAAHKSPHFTRFSKKKAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRA9</accession>
    <name>A0ABM0JRA9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864229</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099709.1">
        <property type="nucleotide sequence ID" value="XM_005099652.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864229"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099709.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="34497" checksum="871F9737A1765BA7" modified="2025-10-08" version="1">MSGSTATCECRQKTEGVPAGTVVLSQGGSTLGSGTVASGTVNNPGKNNNDQTLTCRSESSLGQAGPFDPKIVKFAYGPSSATLTFSPTSPSNLCQGPSLSVVSLCTVDPSTVNPQPDYQLSVNGTQVDTYVQQTLQLQGGAHNIRCLVENLLFPTDLFTDVTESFIAMVPPPDPPEITVSQPSVLSTGEILVKENVTIRVQCEVRGGYPATSDVRLSCPSSQAGSSDVSSVVVTRSQETQCLCTATHDSGCYNKRSDVTIKAAYGPEGVTLERKNVRPEEAGTYNLCPSVTPDITMECSVGVVYPAASFSLAMAPTGIQTFDACTGNDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRH3</accession>
    <name>A0ABM0JRH3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 1 regulatory subunit 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099837.1">
        <property type="nucleotide sequence ID" value="XM_005099780.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856431"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026142">
        <property type="entry name" value="Pro_pase_1_reg_su_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055:SF3">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14895">
        <property type="entry name" value="PPPI_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099837.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50588" checksum="258444E1D1B9B5B6" modified="2025-10-08" version="1">MAKVATMFDGIAVSGKWIWKDDPVNPSLEFVSNNPNADRQDRRRRAKGHDGKGRGDRAASGIQRGGGAGRGRGGVQKMINKSAPGKKDQTEHTIVTLDDIKNVSLERMSEVDQIRDDFYSLYRREQFDFFLLYLLSYFNCFFNKMTLENKKNPMYIEPSVSEKIEYAESCERLSVAQKLLGRAYCILVLGLGLEEQHHMECGMSRVSKTHTDRSRFETFYSFCTFVVWITFRRKEFECIKKEIGRILRSDTFNPAIRVKYAPEEPKGQDPTKAPKKPNEAEEEKKEPEEEKKLTPAEYRRLHPKRPAIKSIINQRSPAIVAILPSPKEESARLFKRPQFTSGESSGFDDEEDDIVDEKYSDLLLDTKKFKTGILGEPYKMFNPQTLSPVGAENEDEEHEGEDGEKRTGEESAAAEKTQASDRGTSRQQTAFSHATTEAFTDDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRI9</accession>
    <name>A0ABM0JRI9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell death-inducing p53-target protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099873.2">
        <property type="nucleotide sequence ID" value="XM_005099816.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846003"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LITAF" evidence="2">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099873.2"/>
        </source>
    </evidence>
    <sequence length="118" mass="13486" checksum="F34421E2E60250E0" modified="2025-10-08" version="1">MADQDSPPDAFLYTDPSKTRVHTTQPSPSVFTPEQAGHFAPRQQYGFEQQQQQQQAILQSQQMMSTIINSNIVFPANSLGSDPEELKCKHCHEKVVTKTTYEFGNYARQWLFCLIFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRY3</accession>
    <name>A0ABM0JRY3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Four-domain proteases inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101849215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100155.2">
        <property type="nucleotide sequence ID" value="XM_005100098.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849215"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045546251" evidence="4">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005100155.2"/>
        </source>
    </evidence>
    <sequence length="166" mass="18427" checksum="91C7AB8FFA7F7F10" modified="2025-10-08" version="1">MKWLVLVLLAVYVGGAMSASCDALKKRRCTREYKPVCATFTRTFPTQCVLESMRCELAKQGWQLDKIVSKRDCCQRPITSEFHYVCGSDGEVYMNPMGMEIAACEKRDYIKSVPLSNCPNIHRPPGTLDGPGIVPVPRPMPMPMPGPGPIPIPAPELLPWEGIVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTX2</accession>
    <name>A0ABM0JTX2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101860258</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101395.2">
        <property type="nucleotide sequence ID" value="XM_005101338.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860258"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF144">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="173"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101395.2"/>
        </source>
    </evidence>
    <sequence length="788" mass="87662" checksum="F7ED598F4291E15B" modified="2025-10-08" version="1">MDFIRTFEVELDRQVYYAGEMLTGHVYLEVEENMRIQNIRVFLRGKAHAEWKITRAGERRAMKQDEHYMDERLLLWGKDDSDPHQGIPILSRGRHRYPFHFQLPDTTLPCSFESKIGNVRYYVRVTVNIPYASCPQCIRYFSIIGPNIDCVDERFLVPVQAVAKRNSCSLCCGKGPLLLRASLERTSFVCGEPIKLKAEVQNGGDSEVWVLCKLIQYVEFFINKGVLGLSKEVRHTVLEAESDKVPPHDTAQLDELMNRLIVPVMPPTMIEVCGLVQIYYTLKLYLETSKGKGDAAEINMPITIATVPFRIPNAPPPDILYESANPNVEGGMYISPEFQLGQVYMGEEVDPETTILYRPMYVCVTGDRPSSNSDAHLLQVPSRQACRSRENVRGSREALQENIICSQNVPQQQQMVKLFQVHDEGGESSRKAGKPVVEDKFLKEITAKIANRQVNGNDDEDKSGVTSGSPPVPCEIESQVHLMRKQLVSKDNVHKALVNELRKHLSEDEGAEKPHPGLKKVPLKKVPDSSGAGVEYNKHLKTEGDKGIGHMPSAVPEFPSHKDQQHGDIGQSQAMSSEVHTSSLNSSLEHAEKLLESMSELEDQEVEVEYSEHSALISTREIVENMDVEVQKMEKRASSKSPVSDFRASYDESMQQYIEELPSPAEELLSTPTAPLILSDMTMATDNTEGSTIDSNPVVSVQPMSSAANRNSSSSMHTDSAGVGGERMVRSQPQVAPKPKQGARHSFPASGAFISESGELTVQVTTRPKSQVVEGSRSAQDEVKDSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTX6</accession>
    <name>A0ABM0JTX6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Androgen-induced gene 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101862590</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101405.1">
        <property type="nucleotide sequence ID" value="XM_005101348.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862590"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045192508" evidence="18">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005101405.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27114" checksum="0D4B06E461A0F0A4" modified="2025-10-08" version="1">MSALIILFHLIVFTIDAVSLVYDIGYIDIGHAGFGGKFKFLTIWNICLQTLYYGLSLLKDLTEEEAGPAGQARRSTLHRWRDSFLTIIAFPVGSFVVMTFWALYAIDRELVYPKRLDGIIPPWLNHTLHTTVLPFLLIEKSLIYHQHPKKHVGILGSCGLALIYLAWILFIAYYDNFWVYPVLEVLAAHERAVFIFVCLLFFASLYILGESITTFNWRKELRVLRVVQISRNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUW9</accession>
    <name>A0ABM0JUW9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864468</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102086.1">
        <property type="nucleotide sequence ID" value="XM_005102029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864468"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102086.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14989" checksum="CCDC6EDCA5C052B9" modified="2025-10-08" version="1">MCSHWVPKQLTQAHKDQRAASALTFLTNYIDEGDDFLTHIVTGDETWLHHPTPESKQQSKQTDSSQQKKVQAGRVSKKKVVQDFDSDADLRGETRHWRTSQSAAFYDEGFRKRVPRYDKCLNSSGDYVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXD7</accession>
    <name>A0ABM0JXD7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">tRNA-dihydrouridine(20) synthase [NAD(P)+]-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101858954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005103788.2">
        <property type="nucleotide sequence ID" value="XM_005103731.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858954"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19871">
        <property type="entry name" value="DSRM_DUS2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044463">
        <property type="entry name" value="DUS2_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="421"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005103788.2"/>
        </source>
    </evidence>
    <sequence length="550" mass="61645" checksum="B9E12F3B3A5B488F" modified="2025-10-08" version="1">MAGSGSRLQTADCSKLPHTSTRYININNITTCCKSREIFRCLWHISKLKMSVRDEAMYTGKVMLAPMVRVCTLPMRLLALDYGADLVYCEEIVDRKILMCQKYDNELLGTTDFILSDGTVVFRTAPREKEKLIFQIGTCDAKRALAAAKKIQDFVAGVDINMGCPKEFSVKGGMGAALITQPEKVREILTLLVKELSVPVTCKIRCLPSLEKTLELVKIIESTGVSAVGVHGRTKDERSRNPNRDEFIQAVAKAVKIPVIANGGSMDIKTLADMERFRERTGACSVMVARAAEWNCSVFRKQGPLSFLDVIKSYLRYAFQYDNNEMNTKYCVLQIIHDKMTELSEADKCLAAKSLEEFADIWDMRSEYIKILAQRKERQDELSQKHADPNHGVKRRKVEGGCVLIELPVRYDKRLYPSTMTPKQVLNDWCKKCHVRKPEYDTTERAEDRCFHSTVKVEGKLYTNPYWEKSKQLAEQGAAISCLVVLGESDGRLAEPQNESEDLRRKWRTVIAEGGGGDSEQEVGDVGGQVSVTDKGQGDMSGAVVNGSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY33</accession>
    <name>A0ABM0JY33_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101848450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101848450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104256.1">
        <property type="nucleotide sequence ID" value="XM_005104199.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848450"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005104256.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18842" checksum="09B37F39E1BD8778" modified="2025-10-08" version="1">LSYVFVEAFPPTDREGEENYVCDVTDNHGHHVTKDYRVTTYRSVYIIEAESGARWINETTLELKCAIWSPRRPRVLLGLTIHSSHGEFSPDQLVAQGDNRYVASAAIHSDTLDRLDPHQMYLLNTYVTTGGTCSATTQIYDGGNHWVDAAHLYNNMLVPDRPNMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYL1</accession>
    <name>A0ABM0JYL1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein FAM155A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104592.1">
        <property type="nucleotide sequence ID" value="XM_005104535.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846231"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031521">
        <property type="entry name" value="DUF4695"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15766">
        <property type="entry name" value="DUF4695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104592.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="26678" checksum="62022BFEBFE11BC6" modified="2025-10-08" version="1">MMTSQASKVLDPMYNFDTHFPERLSRLHIHGDFNASGSFRKKKSRAQRSGARYKTQPVTFDEIKEVDEEPAANSSGSAKDGEKRASSSEQLMGQLQAFSRSMDGLLPKSAVFPDHVSFHVSHSRSGSRKFQRHPDCIPERAEAEAQQKQQQQEQQQQQQQKDQNPEQRLSESSTSATGSLTTPASQQTSTLTPPTEAGGGGASSEGGSPSPVPSPNIAPRRQKITAKAKKRQKAQGEGGDGNLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYU3</accession>
    <name>A0ABM0JYU3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864243</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104752.1">
        <property type="nucleotide sequence ID" value="XM_005104695.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864243"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104752.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="64870" checksum="D75234572A3DDFCF" modified="2025-10-08" version="1">MEEGRHGPPTNYGVVRSPQGPMLVSRKEGERLNFSSSWCHPRFGLRDRLLLSWVPALLCLSALLATTASESLPTLAYAQHARISEICSEKFYGREGTPVKGFELEKVFVAMTPGVRTPVERVHGLVEMSQTSSAECRFQEFAQRHASVKVQSYPETVLLKEEMKSSSAKSDFRVFKRFTESRGCKTNSLSSYGIAQLIQLGEYLQRCYSEKLHSFQSLPLHKEFAETVGEEVLFQSLSAVLHGLLTEKQFVRFDIRKSPANFCKRCKSQVGPCSCREHEDLHYFVEPSFYRERHILKEGLVHVQKRAFLKQHQNIPVKEIISHISRVACGDENGIRGAIQVPLREIDNLFDLSDSFNSYISSQPLFRSYAQARMRPLWEVVEAWLHPTHAPDNVSVEGKIDDFKIVSVDELMMLSFLASMSKTLDRHMAPASRFVVEMFELKSSQHLPHQPIYQLSKVDDVSLNSTSLEAGLQYNDSETGLHFKSSSLMKERSDSKESNVSLSASTTAEKLGVTRHMLSNRHRQRYVRVLYNGDVITQALPACADDQMVSLGLCSINTFLSGLRSSESGSRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZC7</accession>
    <name>A0ABM0JZC7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Matrix metalloproteinase-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101845711</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105100.1">
        <property type="nucleotide sequence ID" value="XM_005105043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845711"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="entry name" value="PGBD-like superfamily/PGBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045821278" evidence="11">
        <location>
            <begin position="24"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan binding-like" evidence="12">
        <location>
            <begin position="60"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="10">
        <location>
            <begin position="244"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005105100.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48970" checksum="155F3A42F28D695F" modified="2025-10-08" version="1">MKKACDVIFCAMVFLVMVERTDAVSVDEGNPLSTILGLSDVTKDLFAKQKSGETFDVLEFLTQFGYLPKTETEHIGHLQSADVVARAIGKFQKFNGLEVTGDLDRSTLTMMKKPRCGIPDIVEEDRGRFLDRLQPMAYTEYGTQSSYELCIHVSVVMWRAFQRALDLWFKEIPLKLRYSAHKPDIEIKFARGEHGDGWQNRFKGRGPDGFMYAFRGDKVYRIGAEGLEFRFPRLIRDIFQGAPRRHIRAATYVKEEGKLYMFKDFRVWRFSNFRLDSGYPRVWTNDHSHLPSAALTLNLNGNSQVFLFGHDHFWEWDVVREKMVPNYPLSLAKYFPHAPLLPDAAFLTSHGNFIFFKYSGYKRLEHRRENSPTLSLGPDLFGDVCKGSATLGAGEQRPLFVDLMTSRGSQQLRLSPLVWALVNRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZJ9</accession>
    <name>A0ABM0JZJ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate carboxypeptidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101852716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105224.1">
        <property type="nucleotide sequence ID" value="XM_005105167.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852716"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF77">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="182"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="357"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="629"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005105224.1"/>
        </source>
    </evidence>
    <sequence length="750" mass="83388" checksum="B859706D046D026A" modified="2025-10-08" version="1">MMRGFDTIESMNADEVLVKRKRGTKRYMVAAAVIGGLFFIVGIMIGYFSHKAEAEGAGRQKPNKRLEPDEFIIEKVSKEFLDSKLRMFSSKPRLAGTKAGTEIAETIKSLWSESGLDEVHMKTYNVLLSLPNASEPNMVEVINKTTGEPVFTSQLYEAALRPEDNTTLIVPFAAYSPAGIVEGNIVHVNYGTTENIESMLQNLTFDLTGTIFLAKYGQISPKQKVQNAELYGASALLLYPDLADTNGRDNANEKVYPDSWLMPDSGVRREMLLDKYGDPDTPNYPSTEYAHYINPETRNLPKIPCQPISYHDAVSLLEVLTGSAAPQYGVVSDNGNGSALEVRVTVNNILQRRPIHNVIGIIKGSIEPDRFILLGGHHDSWTYGAVDPHSASAVLSQIVHLFGQLLQSGHRPRRTLVFCSWDAKEPAIIGSTEWVEENEKLLSERAVAYLNADLIAGGHFTLSVKASPLLQDALFTAAKRVPSHVENYKTLYDLWAARPNDESWNSQEPKVSYAFGSDGDYVSFHENVGISSADFSFTYEKKKFQGANYPLHHTAYDTYYLYKQFQDPNLACMEAGARFWGILANNLANAPLLPLRASRLSSAVSAFLDALTLELQDMLDTDSITLDAVISAVRNFSDATSKLEHDMNDSPELTANPLMLRRYNDKLMLLERAFTHINILPGKEFVFRDGTPGQDVSPEDIYLYDILNTVTDMTHGPEQIEQLKEQISVIALKVQSAADSLYDIGLIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2I7</accession>
    <name>A0ABM0K2I7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adhesive plaque matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107250.1">
        <property type="nucleotide sequence ID" value="XM_005107193.2"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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            <begin position="19"/>
            <end position="1446"/>
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            <begin position="416"/>
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    </feature>
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            <begin position="443"/>
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            <begin position="816"/>
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            <begin position="1221"/>
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            <begin position="1258"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107250.1"/>
        </source>
    </evidence>
    <sequence length="1446" mass="165444" checksum="6211325769ED54DC" modified="2025-10-08" version="1">MTLVVALIALSSAVLVTSSGLQDTPISPRNDESTMPLGPQLPREWLPEKFIWGSTDIKQKDASFPHVSKSLDFDIAEVNSLQGPPLGSNVKSTVRKIFEISALRRKRQTSRFRKVSLPPVPLRMFSDESEHGLRRKSGPISYSRSHPKEIPRIEGGYDESHTSRNPPNEFSRTRTNKRGPPVDDTPLGSNREFHKSLNYGRSNDRNSDSGSEAENYVPQRFPQMQQQGSWNSKNYNSYSPKTSDFDYDRTSTGTYRSQYDSNKQSSSTSNRRDSYDHSNQDNKYNGDQNKDYNGEGSYKTGEGLVPPVPLPSDKFYGHELDPYERAFLFPQSKSTFPNERVDLRRFSDPLPDSYDSRSEGENQKGDYNPVTGDNYNSGNTELYAPRQDSRYPRPPTGPVNNGVSYNTNPYSVPNELPRRKEGNYDNARYYEKRSNDKIYGTSRPEERYYDGERPKDKTYGTSRPEQRHYEGETSPRQHNDDIRANMDRRSTNSFYNTDRTKDTYRQDYLPPPERYERSEDRYYENASPSSRYYDNKPYRRPYNTRRPENSFYEQRGHEDQYNGRPSERYEGSRDHYPQSSSHSPRTKNFYYKPSKPGLRDGDRYNDRYYKKPAYENDYTNNHRFSSNSDFENSGHDYRSDFSRPKKGRPVYPSPDSDYSDQYEIYRNRNESRRRPYYDPYLDSNSNSYPPQSGSSFRYPARKYSNQAREDNDYQTFPDYNDRNSPNYVSTYENGPGGRPYSTETVYNNKYRPSQSEKEPNYGNNYSSSYSSSPRRQQGSESPYQVRPYTSSATDYEPYKGGQFSNSYRGPPRRQSDQGSSGQDNNGGQAYGRVTESRDQEPAYPELLYRDSYKARQTTDSYRFLNPPYSRNSPQGYGIRPYESYRHSKETNGVTETDYHPAEVHSFTKPQHKGVGEDEGDVPRDKRQVSTAAQTRLQNRVNQSPTPNLRLYGDVDPRTIGAAFGSSADNGYQDARATPYQPPSNLGGRIPFGQAPNQQTPGPYSVYPQQPEGLTQRIRNGGTQQYFPQNDYRGEQQILPSPNLNYPRPPQLLPPELTSGSGYRNTVPTAGGFLGNRQASFYNSGPQTYPRPEYRVNPAESTYDRFPPSRPAINTYEPPIQTRPEYRPPPTYSPQLLGDPFSRDQGVSLQTPYANQPPQQNYPVTSSSQGLPERILVPYVRMHPNQKFARERQVGLPFRDASESQFLVAGKPFPMEGDYPIPTSNQYNGHNNPSKYTQQYASPPVRNPYTSYLAPEYQDPSSQLQGYPSSQYPAEPSGVYDTADNFPYLTSAPQSSSYGSDGPTGSRLPLTFAQTRQNKYKGLAPGVDNANYQNTQLVDSSKQDQIPPPKSRVSFSRFEDNKNSYSPTPDQAEKPNFGQYSPNREPGPQGRFPRGSSRTSAQKDIRAPRVGQTDVSPTSAFIEPLSSMFKRDSSGNLHIHLYIPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2Y2</accession>
    <name>A0ABM0K2Y2_APLCA</name>
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        <submittedName>
            <fullName evidence="6">26S proteasome non-ATPase regulatory subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101853409</name>
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    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_005107482.3"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CSN3"/>
    </dbReference>
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        <property type="entry name" value="PCI_dom"/>
    </dbReference>
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        <property type="entry name" value="PSMD3_C"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
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    <dbReference type="SMART" id="SM00753">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINT"/>
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    </dbReference>
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            <begin position="258"/>
            <end position="437"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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            <end position="506"/>
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            <begin position="1"/>
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            <dbReference type="ARBA" id="ARBA00022942"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107539.1"/>
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    </evidence>
    <sequence length="506" mass="58116" checksum="7CB7D11AD841EDD8" modified="2025-10-08" version="1">MVVKNSEDVEMKDVSEASTSNKQDDSKKEEEKKDPELLTLEDIKEQVRHIEKAVATKEPRFMSRVVRGLMSIRRKLNPRILRSLMKGYFTAQNIANKEELLPFLADGQSEGMNGVSGTFRPRSGKLASAPIVPEIEIYIHLLVLIYLIDTKQNERAVECSELLMKKLALLNRRTMDMLSAKCYFYYSRAYELTNKLEQIRTYLHARLRTATLRCDHEGQASLLNLLLRNYLHYNLFEQADKLVSKSNFPDSASNNEWARFLFYLGRIKAAQLEYSDAHKHLLQAMRKAPQHSAVGFKQTVQKLAITVELLLGEIPDRSVFRQPPMRKTLAPYFQLTQAVRGGNLQKFNETLATFGTKFQAENTYTLIVRLRHNVIKTGVRMISISYSRISLSDIAHRLALDSPEDAEFIVAKAIRDGVIEATIDHEHGYVQSKETGDVYSTKEPMAAFHQRISFCLDIHNQSVKAMRFPPKSYNKDLESAEERREREQQELESAKEIAEEDFDGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K346</accession>
    <name>A0ABM0K346_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101861687 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107666.1">
        <property type="nucleotide sequence ID" value="XM_005107609.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861687"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029281">
        <property type="entry name" value="FAM194_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093:SF16">
        <property type="entry name" value="FAM194 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093">
        <property type="entry name" value="SIMILAR TO CHROMOSOME 3 OPEN READING FRAME 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14977">
        <property type="entry name" value="FAM194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM194 C-terminal" evidence="2">
        <location>
            <begin position="411"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107666.1"/>
        </source>
    </evidence>
    <sequence length="1118" mass="125689" checksum="B34C3CF0D8F94D04" modified="2025-10-08" version="1">MESNHFFYEQTRFRAFPKRFKKMPEDLPDSLKFAHLNPKVAAYLASKEKQKHEEDMFGDGLGKKSLMPEISQAFNAVKNRLDSSLSNDEDSQRYLFEEARVSAGTILMQLSRIIYYYDNIAGHIPKSLEYQMMSSFTELTADVQLVPREWQTTAMKEAYLRRLTEAQSDDDQEKVAASVMEDGRSSRAQSAASDSGKNNKKRLLAKGTAGLPEIVEDSEGIAESMRHLAKRSDSRMSIASRRSRTDRNKSIDMKGPGSVTGKSPATKRGFHDYDFMSALTETPSDTRSTAMANPSYYMSVIQFQLSSKACEEKGWIVQKGREEELAKEAIMEWCLQLLLQSLKDIKEQRTHEIEMGYNNPVVVRYYGDTRKETLLKYRKSPVRTSQNASMNSMKGLKPRIPHMYDDSNEGKQLMKTCHIDGTMVAYYPSGRPAVVASAAGFGRPGYYTIVYDDDPDMRMLATFTPSGRGVCYHMNGNIRFLSTHKGGHIANREGRIIRHWKWPQAQVKLTSPVSFQMNQHLGFRCVSENYIIILFSCQKESTRFFVSATPGACDVKPDENDQLLTTFTFSSKAAKDLLRLFAPKTKSKSKRKKQEKMTKQLAELVRSVDNQEKLIYDLESDKELARLQRKARNLVDDWLEHYRVTIGLKSPTLLHIGDSPRKSRMGAYSAKTTDGREDRRSTLGISAQDSVVGTARVPSAPSRASVMKQRSGSAGSDATSPNRNTGSPTVKFDQRVEGVDIEIDLEEVEDGRPFTSTLSDKLSRFSESTLRSKSASSPTKSVSRQPTAVSLPERENLSANLNNCPQALRMQMLSDARPQCRCSRHSIPYITDVEYERYVAEAAPRNQLQIIVVVSSLYPQTNHAEMMLNQIHQNQNRNRTRPCMQCRSDMFRILKYDINTAMEGSDHTQPLLLTRHNVVPGMFLIYADGRLLFCDHIFNGYGNTRKDFKKQVMKSKLDFIHGFSLPKDFRFSPSQGTHGPRSPWGGEIGGAGVDHFGSPGTALTRSLTDLGARDSLTDRQMESLRVAWEMLGQMLDLQEVTAQESSRIPELPPILVPSSKKPGHGAGAQYDAIRHSYGAPPPNRSRGLPRHGAARPGLATSKTSLQTISLRNNQLTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3P2</accession>
    <name>A0ABM0K3P2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein 128up isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101846915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108025.1">
        <property type="nucleotide sequence ID" value="XM_005107968.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846915"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="288"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005108025.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40862" checksum="FC16C08EE1821BF0" modified="2025-10-08" version="1">MSILQKIADIESEMARTQKNKATSGHLGLLKAKLAKLRRELIEPKGGAGATGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGKQVIAVARTCGLIFIVLDVLKPLQHKRIIERELEGFGIRLNKEPPNIQFKKKEKGGLNLTSLVTQTELDNDLVKTILNEYKIHNADITLRYDATTEDLIDVIEGNRVYIPCIYLLNKIDQISIEELDIIYKVPHCVPISAHHKWNFDDLLEKMWNYLQLVRIYTKPKGQLPDYSSPVVLKAGRSSVEDFCNKLHRSIIKEFKIALVWGSSVKHCPQRVGKEHVLNDEDVVQIIKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3Q5</accession>
    <name>A0ABM0K3Q5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat-containing protein DDB_G0287407</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108051.2">
        <property type="nucleotide sequence ID" value="XM_005107994.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852959"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF40">
        <property type="entry name" value="WD40 REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF4062" evidence="2">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108051.2"/>
        </source>
    </evidence>
    <sequence length="215" mass="24702" checksum="E474F5C66E3F0FDC" modified="2025-10-08" version="1">MFRKTPKMAPVSSYKLKDPRVCRVFVSSPFGGYEKEREELVLKYFPQLSHLCQGRGVQFVAVDMRWGITEEAATDAQVVSICLREVDRSDIFIGFYGQRYGWHGAKDPMLQKNIDNAKKRYPWLTKVKDRSVTEMEFLHGHLNSPGALPSIMAFRSKSYDDQKRKKAEEKKNSREATKFTVESSEANKLLTSLKERVASTKAKCVAFNDDYKTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4K2</accession>
    <name>A0ABM0K4K2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized oxidoreductase MexAM1_META1p0182-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108611.1">
        <property type="nucleotide sequence ID" value="XM_005108554.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845035"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005108611.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="29734" checksum="A1DCA98FB4E3098D" modified="2025-10-08" version="1">MASRRSQHNEQLKGKVCVVTGASSGLGESIAIMFAQRGASVTLCGRNEDRLQASLTLCVQASGGQAGRFLAVSGDVVDPSARKAIVEKTVEKFGRLDVLVANAGVADPQCGILTASEETFDKIMNTNVKAVFFQIQEAVPHLEASKGNIIVVSSVSSKIASTPNIAYPMSKAAVDHMIRCLAVDLGPKEIRVNAVNPSYVPTRIHRVPSETAGEAQEFLLNIEAMVAAKHPLGNRCISKDAVTEAVSFLASDAARFITGQCLLVDGGRHLMGFLHRPVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8K7</accession>
    <name>A0ABM0K8K7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101850294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005111377.1">
        <property type="nucleotide sequence ID" value="XM_005111320.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850294"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005111377.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42322" checksum="4DCA9F5BAC43C121" modified="2025-10-08" version="1">MDQKQTNSTLTEKISNLSSQSLIYNSTLVANRFAERNERIKKWCTKPEYDKAIQELRKKPIIRIAGGKLEWCSVPKVGSTYMKGLTNNLFGEKPLFIRKPKKNVDGVKRFFFVREPYSRLVSGYLGKIATHPVWWNTLGAYMTAYFKPLKDRYKPKCGHNVTFPEFIKYFIHSEETGRKQNIHFIPINRICDSCVGKYDYIGHLETISDDLKYIFQTVNESQDTSVLDSDAMTISGKCKSVVKDFYGQRYARCLSLCDAMKKVWWSFHVRGLISKDIEFPIDEDSCDQTTGAHFASLALKANAESRGKFDKRGQKREFLISLYSQVPLEDRVKVKELLAQDFNLFGYDAQPDYVFPQSEENTQTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB03</accession>
    <name>A0ABM0KB03_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854925</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113259.1">
        <property type="nucleotide sequence ID" value="XM_005113202.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854925"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40240">
        <property type="entry name" value="PLEXUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40240:SF1">
        <property type="entry name" value="PLEXUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113259.1"/>
        </source>
    </evidence>
    <sequence length="742" mass="81374" checksum="F5AD9DAB479F68D8" modified="2025-10-08" version="1">MPSRVVCFVCGSLGGHFQLHSRPREGSAYFPFLEHHDPPKGSRLPGQDGVVDACRVCYAFLTQQWESYERSSTPAIKRLYWLKRSDDGQFTGAEMKLQGEYMAQVMGLQYQPSCGDNCAPLSPEDSANFSSRDGFGMGSREHESHGRKFEEREGVLDLSVPVKSETSSKSSCKSGGDAERNGRPSSRSKPVIEEFSFVCFTCGVENQGVAAKFISSTYLAASEPYFPFLTKVTPASGAIPLSSQGICRVCDHCFSSLCHQWLTYEQHGTPSSARIFKVKDSFFSNDSSIVMGGANDVLGPSAREVCYLCSQPWPAPKMCALFTVPSGKENRMMYFPFIKELRRPHGARPLNPDGSVRVCISCYGNLQVQWQAYETENIPLLQRRYSLLPLSSSAQGTSLSASSSSTTDGGSDVKLTAVKREEVPKSLTQPLNIDVSESPTFSKSHSHGLLAVVPPSHSSSATNPSANHASKTSATSSIMNSSSVAYERSLSAEQKQSSGGATGQASSSTTIPHPLQQAGERPKKVCFLCGEKCLASRAKTLFSYPVRHEAKSASSQSQTIPFFPFLANQEPAPGADSFTEEGSVLSCSYCYHSLLNQWRDYEESKSPTEKNRWLRKYTLNEFVCFVCGTSVPRRKMRTLEVQKFPFLREHKAPPTALVMWAGEAVGACGACHFSLTHQYADFERLGLPVELRKYNWTVQHQAHIDENSCDTQDSIQRPPSASGNEDSNLSVTDVGEDSNSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUM2</accession>
    <name>A0ABM0ZUM2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Laccase-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106011057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934797.2">
        <property type="nucleotide sequence ID" value="XM_013079343.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011057"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="173"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="332"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012934797.2"/>
        </source>
    </evidence>
    <sequence length="504" mass="56626" checksum="91239079659F39E6" modified="2025-10-08" version="1">MVMKGGAMFASWTQSSNNNVVLLSLLLMLVVLFGDLDVANGKLRHHMNYYDIEDYNDHPCKRPCLDGESPMTCDFDFLVEHYHTLTKACYDCPHNETACALPHCVPADGGLRGLIVVNRKLPGPAIHVRCWLCVFKELLPQHCNRELWKGAIGVKGKGIYMTIMDPVTGKNSTTPREEFLLKPGKRYRFRFVSNGILNCPIRISIDRHVMEIIASDGYPVESFDVESFDIFPGERYDFILTTNQPVGNYLLRVQGLADCGVEFKNAHQTAILQYEGAERDVGYNPPAPELLGTIEPRNKRLLTPQMNHISMMLPPAPALTQMGDIPKEMFCNNDTMTLNCTEEFCECIHVLKVDLDDVVEILLVDEGHPWNANHPTHMHGHGFRVVAMDKLLKCLGYSKPAVEVEFVFSGMWFLHCHIEYHVEIGMGLLFQVGDVSQFPPTPPRFPTCGNWEPGEAEDITGDVPSPEGGNGAQSVNVLTGSWFCLLFLLPFMHYMFIKVSTISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUS4</accession>
    <name>A0ABM0ZUS4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium-dependent multivitamin transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101855705</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934878.1">
        <property type="nucleotide sequence ID" value="XM_013079424.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855705"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF2">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012934878.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="62172" checksum="EA3B1B2CEA8386C1" modified="2025-10-08" version="1">MASPELHWADYIVFTSVLLVSAFIGLLYALKSRNASAEEMLTGQRKLPVLPVAFSLSVSFVSAVSVLGIPAEVYANGSDYWMVGFGFFWSLLFVGYVILPKLYKLNITSAYEYLELRFNRPVRLMASAVFLFFMICYMAVVLYAPALALSQVTGLSMEVSILTIGFICTLYTALGGIKAVIWTDVFQTVIITGGLLALLGRGTVEAGGVSQVIEKVVNGSRDATYPMDLNPFIRHTFWTLTIGGGIGMAAIHGGNQATLQRYMGVESLRKSKIVLLLNIPLSEFFLAILCLCGLVMFAYYYGRDPLKSGRISKRDQLLPLFVMDIMGDLPGMPGLFIAAVFSAALSTVSSGVNALATVAVEDFIKPIYLRTRGIALEGRAKSITVVVTALVFGMLTIGAAYLSGLLSSTLLIIVVSIFGMMGGPLLGIILLGLLCPWINSWGAGCALLSSLVICMWTAIGAITRPWPKAMFDNSTNTTVVVNPPRHAVDDWYDLSYQHYATLAVTVCLVVGSLVSFLTSCNRGRALNPGTFYDTLRPCRKSPLQESTFDLEKSPQHNKAFHASAGTYGTANSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVQ7</accession>
    <name>A0ABM0ZVQ7_APLCA</name>
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        <submittedName>
            <fullName evidence="12">Neuropeptide receptor 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106011228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="nucleotide sequence ID" value="XM_013080076.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
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            <begin position="100"/>
            <end position="121"/>
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            <begin position="38"/>
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    </evidence>
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    </evidence>
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            <dbReference type="RefSeq" id="XP_012935530.1"/>
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    <sequence length="350" mass="39675" checksum="D48AC12875615425" modified="2025-10-08" version="1">MGKFKPSQAILPTEIRQISEITIDFTLSFLISVTGIVTNTLVIIVFARLGYRESVNISMTTIALWDLAKCAGAALQRFAGPLSLWSLAVAESWSNVGVVVMNYFVCFSSYVTSVLAAYVAVERCLCVCLPFKVKWLLTPKVTLFMCVSISIVVFGCFAVMFSIYDVIWVFSPEFNSTIAIYRYNTFALENKAILFDYYNYSGIVWPTASFVVIVVCTTIIVYKLAKSSEFRKGNSDVSQAEKQGEAPSSQNLSGRDRQVVKMLVVIIAIYVINLSPRIALYIAKQIIFDFYFLRKYHNMFLFVVYLLYIFDLTNGAINFFVFYTMSTAFRSKFLNMLPANRFKRCCSPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVX7</accession>
    <name>A0ABM0ZVX7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101852610</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">LOC101852610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_013080184.2"/>
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        <property type="component" value="Unplaced"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1767"/>
            <end position="1794"/>
        </location>
    </feature>
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        <location>
            <begin position="1796"/>
            <end position="1826"/>
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            <begin position="1828"/>
            <end position="1857"/>
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        </source>
    </evidence>
    <sequence length="1917" mass="210376" checksum="FA2E8EA0A757EDAC" modified="2025-10-08" version="1">MDTVSCTGARNSTKGVQSRSVSKDAVPDSSSKEKKILPGRRQQRHSTEIGAEYHRWWAVRNAVGFETNEHIAGLLLDGFHALLEQIVFMCGGPAYHPKPEQNKKSSADSVNQGGATSSTSGGAEEDEEFTEYKNAIMFYCDTLWQMCGQQDSRLQELDKASQPMQDFIIRLMGYLKVAKGRGFSLNYKKKRFKQSSSSNSGAKERELFPTPSSSSQGPSFVGGQSMAAGNIQLSNPAVQFVPTSSAVFSKPHQQPWLHGRLAYVPNSGSYAFTPTSGSSVDGTKEQAEKEIQALRDCNNMQSCAITHSGRHIDNTLYNLIPGANPVGYSKENCVGNSFPSCLTEQEFDGEEQSWQRQIRSSSKRKDANFADLPQVKSELVFTGSEKSVCTGDVCSPPLPPCFEEPDSSSYHASDFPSQKSLPMCGPANEISENTWREEVQSGQQQQPPSTSDILEGSLKSLLKKPVNLNSYSQRKCHENNQAAGDADQMKGKQESLRSSGHRVVLTEDVHSSAQYGKKLESAVQKLSKLTTDKESTCRSNVKVEKYSKSTNTAYSNEVKMDSQASARDSRIESELSSEKSSKAEVRGGNTSHKMASSEHLLPIQPALCPQGLSAPSLTTSLGTPVFFYPAQSLNSRDSSLASLSSLVQNIVYNSHSTVFKSLSVVPGMTMSSSVASQAVVSQLSLSQDNNSTKTVTSVPIFSTHISNSSYKPTLLPLYISPAGVGALSLAKPGMKSVLTQPSALKLVQPTTVPLVQTLDGSEVKMEATSMSQVINLCGADELKITDVRSCAEEDFLSADYMKGFEEVQCNKLLSSGDACPDYSECHGLSGKKLEFDSLSSDESHPTLSQRRTDEKNTGPGPGNAIATEGRPGCKHGNVLNSKVLSQLPHSQALESLKSAFLEKTKNTATSLKGEETQKITGSSFSSQEKGCSDSKNVVRSKLNSSSSNTKTPHWRRLACSSCQLIFFSGTDLLVHRYEQHSHVCGECDGRFLSRARLEQHKAADHPEIILCQRCRFHTFSKSVMDDHLRDVHDLAPETEEKKSKERSDENPAQTESSCERTTGQGENDSQKANTDGVSEKCEGPLTVEGRSVGTGNVNECRSGGDKLTDEPFRPHTVSRDAAQDYGNGSRPQDNGSSLRGKEGTKRKLKEDNMGDFAEWGKNCSSGNASGQSLVSKDGLLPNQGQPCPGPVFPSFSHQPAARLSPRSAACDPVSSMYSQVMQHCLLDAPPSFLHISDPQSQLQDFSDPKHERSPKSQVSLLLDLSEPRELQQTHMVDSQPLQQQQQQQQQTQQQQQQQQQTQQQQQQQTQQQQQQQQQTQQQQQQEQEQFSLEMNEQREQLSECDEPPQLVIDTGEQPSGREENFFNNTCRQADVGQGRSEQEAAASWHQDQPLCLVVHNRQHTMAAGDGKNSSNSPKDNTSEDWKAFSSLLSVDQPPLDLSMLDQGVSYVCPPDSGSVVNTSAPVQSFMQTSEYSQATYPFREDVSTNRYGVCESAPGIDAKKKLVMKISLKRSAVGSPPEEAPRKKRKRKRRRKTRVVSESLVDTTAVDIDNPEVDDEGNCVLLDATMDSALCRHGVESFAEFDSLRRDVSETEENPRSSNVNVSHVALDGSSCNDLGVAGKVLSLRERHRMSSLPPKKRNFRKSPRGHAKNEEMVPNAADAVNPTLVTDDKSFPDMERGTVHKSSTGRSARSQATAEGQRKCSGKELRSHGRKSSTSSDSAQQVTAYPRTNEGDYGLVEESTEFSGKDGSECVVSQSSQRTGRYACPVLNCSATFSRKWSMDMHINKVHSGVLSCTVSGCREKFASRRDLRQHVTTEHKGKTRKYLCSWPGCSKSFYAQTHLQVHNLTHTGEKPVACQICDYRCRQRTALLWHMRKHGIFQSGGPESPSTARSVSLRAHRNKSAGRDHTPASVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWC3</accession>
    <name>A0ABM0ZWC3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC106011290</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106011290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012935879.1">
        <property type="nucleotide sequence ID" value="XM_013080425.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011290"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF82">
        <property type="entry name" value="GH19567P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012935879.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35428" checksum="0C0A2C49E94832B0" modified="2025-10-08" version="1">MPSTRSDPRQGSQHSQHGSSSAHPQSSSHSPASRQSSRSSSKKGSRRNPRERARPQRQRTYRSRAASWLEPRLLLIATATTMLGFVLQIIAISTDSWLILDAPDGIFRNASGKYLVEAYTGLWRLCRVEIEKKMGPNGKWIEEKHESCEPHNLFPSEDEIQSNKDFDSHYLDFDVKDLIQMDYTRTAIAFTIIALMVMAIGHGFAFYALRRPRYIIKRLAALLHFMAAACLLVLNEVFVKTVEHEKENMPGRIPLQAETHYGYSFILSWLVFCFFVLAGLVLLFTSHKKKAEYADSSEALEDEPMEIFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXM2</accession>
    <name>A0ABM0ZXM2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">G-protein coupled receptor GRL101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC106011444</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936600.2">
        <property type="nucleotide sequence ID" value="XM_013081146.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011444"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="981"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1015"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1056"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1099"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1150"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1207"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1238"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="14">
        <location>
            <begin position="235"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="992"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="719"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012936600.2"/>
        </source>
    </evidence>
    <sequence length="1312" mass="146377" checksum="E8E2A36AD57C4755" modified="2025-10-08" version="1">MTEVPVHTSTGHFDSPLVEDCYSSQLDLLLIVNGDKKFRKFYGKQIEFFSKFLEVFSSGRADDFWRVNVSLALSCVSRYEKNFQILLEFGQYSELTALRRAFMNSTLRQSTCLLPKPKNVYRAAMNYLDSVSAPGRRSLIVLLTFRGMNRFTAKSLLSELEPVQNRTIVTIFVRQNIPASRASMVYAASHHLRSVVILSSFRFLMADQDLSLAVCRRCHRGWIFNSLSSHSGSIAASSCYKILPRADSHWVDANQQCLNIKSTLVKIETVEELTFLENSLSHHMNLVKTANSSAPDEQNFFIGLARNKRSLRREHEWLNRLPLVHSLWATDQPYHRHTGGCAYWRRPAGGGSGYWESEGCGKVISGAPICEAQVNVAVPKVVGVTCPVSEIQKKRALQRGEVAFNVENGGSLKPYTLYPASSRQVYAELPRNNLSFSVYQRQTQITPVSHKDLRLFTCSGSKRLIPYTSVCDNRRDCRKRDDEKFCKNDEDDGDYFRCANGARVLSDFACDLFPDCSDGSDEMGMCSACANWMCPNGECLPKHWFLDGRNDCTGCEGEHEAGRVVEREIAARHGVTDCVFTCNRTDCVTRAMLGDGVLQCTGPEGPLDETVGALESSSCYGENDGVGLSNWGPRCVFLEDPYGGVLGCPNLRHLQGCEDFVCPEGYVKCPRSYCVPVQYVSDGRGQCPLGEDEVLMKLDCTGLFQCPASAMCLHPASVCDNRRDCPSGEDEQNCDVTCRTGFLCVSGTVVKTDYDSSLPLTDLGFVDGRTRYLDVSGVDVSRAFYNFTCRKWRTLVHLEARGSSLRLDTSGWCPGADLTSVIYLDLSDNFLQDSHLTSLFSALDSVRYLHLSHNRCLRRVEIPWLKKLAVLDLSFTGITFFKLHPRFRNLNTLNLKGTQITRLTAHQFPESLKISQLDLRLNSIKHLEKDSLSGLIINKLWADSYKLCCPQLRVVVTECLAPSDPFSSCANLMEGFTSRTLLWVSGVLAVAGNLLVVAHRLVLDRSSLRLAYGQFVAHLSLADFLMGVYLLTIASADLYFRDAYLMHEAGWRESALCHLAGCVSTLSSETSIFFVLLITLDRYLVIRFPFGQYRISGRYVHVLCALAWLLGLSIALLPFVPSFRHWQTYTFTGVCLGLPLSDRSVPGFCFSVSVFVFVNLGLFLLVAAGQLSIYRAMADTRRQMARRMGGWPGAGGREQDLEVTKRLFLVAATDFLCWFPVAVLGLLSLSGYRLGYDAYVWSATLLLPINSAINPILYNAHNILNTSKRLLKHLWLAATEVKATAATGDKVRAAPEVKFKDATEAKVIAAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY29</accession>
    <name>A0ABM0ZY29_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histone acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101856257</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012936868.1">
        <property type="nucleotide sequence ID" value="XM_013081414.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856257"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009464">
        <property type="entry name" value="PCAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06466">
        <property type="entry name" value="PCAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 15" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="480"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="17">
        <location>
            <begin position="715"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012936868.1"/>
        </source>
    </evidence>
    <sequence length="809" mass="92236" checksum="FBD35B2E3140B14A" modified="2025-10-08" version="1">MSACANGEATADDAENATKSSSTPVSASEMNKTNNFQRIAQKKLLVRGYSRSKKLEKLAVYSSCKFEGCKCNGWKNPNPPSQTPASDPNQPTSNLTDPCKSCRHNLGAHVSHLESADEEELNRLLRIVVDVENLFVCVTREEDAEAKQVYFYLFKLLRKCILHMSKPVIEGSVGTPPFEKPSIAKGVTNFVVYKFGALAQKEWQTMYDLAKMFLHCLNHWKLWPPASRGQHLGEKDENDYKLNYTRWLCFCHVPAFCDSLPRYETTLIFGRTLLRSVFQTMRRQLLEKFRAEKDKMPPDKRSLVLTHFPRFLTMLEQEVYGNNSPIWNPEFSQQTNNLPSPSPADWFVSWLVSPGGVAGVSGLNRFTSSTVGGEACSGFNISPGLLTNGRRSSRSQDAAEKRKADEAGLSDGAKRPKIEGDISKEVLEEVLAEINSEGDGVIVGPEILHPSHAARDEQARQEEKDGKIDFHIVNNSLSHRPTRQVFLWLIEVQNLFSHQLPRMPKEYITRLVFDPKHKCLVLIKNNHVIGGVCFRMFPTQCFTEIVFCAVTSSEQVKGYGTTLMNHLKDYHLLHNITHFLTFADEFATGYFKKQGFSKDIKLPRSQYLGYIKDYEGATLMGCDLCPRINYTDFSRVIRKQKEIVKKIAARKAIETEKVYSGVGLFKEGIKLPLPVEYIPGLAESGWKPAAKKEKEQSLEPDQLYNIVRTILQQVKSHASSWPFLKPVDKSEAPDYYDHIKFPMDLRTMTERLKARYYVHKHLFIADMNRIITNCRSYNEPDTEYYKCANTIEKYYITKMREAGLMEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A136</accession>
    <name>A0ABM1A136_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mucin-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938683.1">
        <property type="nucleotide sequence ID" value="XM_013083229.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853092"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1503"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="930"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="969"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1426"/>
            <end position="1440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938683.1"/>
        </source>
    </evidence>
    <sequence length="1524" mass="161043" checksum="06724B684E04202E" modified="2025-10-08" version="1">MTAMEEDVDDRFAGIDIDSLLNRRSQERKPFSYGRKKALYESPEFIQRLSGEETVLEGQSLVLECKVQGFPAPSLRWFKDDEELLDHPRIHAEGDGKGGYSLYIDNVNKGDEAAYRCRAENMEGACSCCFFLSVKAKKSNKRKKDSKSAPNKRTVSFPPMFATIVEKVEEEEKQGKELETLPPSPMTDFYYALTLKGRQTWPTFVGDWAFANGAQDLNHTRRRNSTGSMDSEGLDYTSEEESSDDDDENEEGEEEEEEQGPPSKRPLFYLDHSLEAEDLDGPTPPAADLAVCNKNSLDLNRPRAENSSDVENKQGRTNNSGTESMTGNPQAAKGLKRQSHAILDENLNPQTTTLGTEENKNIPSSTSVKENKSLTTEAVNNVETGEDEQEAEIPPKEEGAQRKGRGSDIQRGKMTVKCVNVITPCAKGEATPPIVVEMWEDDKEAANANDVNKSGGVPPALSVAEPNREDREPTPFFRDSGMRSPTLNISPGQQKQTIPQFTLSADVTGDRNEREPTPFFKGTSTAASENVKPPSLNVPGATSSGDGSSEFHREPTPIPMFDKKVTSVGQGHTLQLPGADFLSVRGPRESTPFFTEEEKEQKNQQNEAGLLPVNPRRFFPLSLSPSPCSSPGSSASPSPLNSPTSSPFLALPSSPEVGSEDRPPTPFFASEDGHHPHYHHHLTPRGQSLSPERQLPIESLKTTMNQVQATIQREQSPVSYRSLDSKRIEMSSKITLSSESAAPQMKNRPVSASSEQAHITASAETSSSLLAESAEAKPAINETPQVSHSSPPASHKTIQSAITDKAVGLDNKTNTSKSNQNTKQGGTKRVALSALQVASAGTNHGGPPSPTRSSSPQVTYQSTVKDTAGPKPGQSNRNASASPTFHVTIGVKSDLLMQASASASQTSSSSVNGTSKSPSMPVGATKPTTVSASVVSSSEQTKNNNNNNNTSSTTGTTKTVEMSKRITTKRTTTTKSALSSSETKVVQKPSAPPNSAQGISPTQSATVTKTTVIPVAVATTPISAKSQDARTSGIPAPHAKSGTQPESTSQHVVVTKPSTLAKPAANNKSSATTLSSPSSSPSSSSTTTTTTTTNMKGVTKAARTAQNGGAASTAEMAAHRVNATKENTKTLVTTTARTSVAPTTSQPAGTTTARNSPADANRATPTASKIAIPTSKPQGGTGTKIPTPAGGNNPASTEASPAHQTTTTSSATDVRQNTKPSSGMLAQTKSSSSQMAGKSPSTQVASASLDATNAKNSKTSGISSVSQSASTPKTSVPQSSPTGPSSSTDPKSVLAKSSAITEDANSKRESNPNMVKPRSVCGSPDPSAIPATLTKVPVISAPIQLTSAIAQSVTSVPAIPQALSRPPVSTALEHVTTGNGNGKAGSKSGSGTAVLPRFSSLLKSKNAGPDDKTKSKNSDTAPQKGGKVKKVKVHSTKSKTKLSSEPSSGDSAVSGRTRRRKSSGASRNLVKCSPFGRYTTEGLILILFATAFCLHLQMGVEKFVCYILASYYTFCVLRVLGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1S9</accession>
    <name>A0ABM1A1S9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012028</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939082.1">
        <property type="nucleotide sequence ID" value="XM_013083628.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012028"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939082.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43022" checksum="857166B1F18601A6" modified="2025-10-08" version="1">MTDLEGTDADGELSDEEVLRSGSQTGVSDQEESQQKVRMGRNVSTRVPIVSLTAKVDNSPSSYINSSSDPVSSILERIDAELDDMDRRNTQTFPSTQAHTSALRPRSSSHGKSSPADTGLGSVSFADDLELTDKDRLTNCHPQQKDQISGSAEIYSEANTTDAFTDDDASRRHDDNNPSDLDSIAAQQIDRKFKEIMRKKKVPPDLPPHPGRPLGALSSRLRSRSANRASANMLSTGTDDKKQQGTDDKDGGGGDGGSGGTGYGQTSGRLGFGAGYGTDNESVKTEDFESKFMNLIVNGSDTERADTAGSAASTARNKSESRINGRSDRTRGGGACGERADKNETALKNTLTPTEDNKQENKRDDANDIIHRLRSIAQSSTPAAPTPILSRPRSVSPTRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A227</accession>
    <name>A0ABM1A227_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101862657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012939254.1">
        <property type="nucleotide sequence ID" value="XM_013083800.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862657"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044957909" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="28"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012939254.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="61426" checksum="9F11D94CD7BA501C" modified="2025-10-08" version="1">MTTLRSTLLVSLCLTCAHLLDPASGQQQQVVSAPSGSYMGSTLTAFNGMEYLAYRGIPYAEPPTGDLRFRKPVAKTPLSGVYNATEFKPFCLQFRPGLFGQGVEDCLYLNVYTPTSDPRRKPRKVFVFVHGGGNQNGFSDLYVPGSLVSWFDLVVVTFNYRLGFLGFLSTQTPACLGNFGLWDQITALRWVKDNIASFGGDPDAVTVGGESAGSIDISVLALSSHASDLFHRVFAMSGFIGVASGANINPDPVPLTLALARREGCLAVNTSDPVSDADWSPVITCLQKVPLERLTTTAGLGAATTTGPVVDGDILVKDLPSLFADVQYMNSTGVKDKDFLVTLVENEGALFQTFIDASLARMSPAQVNALPANTFLRNLMEPYLVPLSPGGNVDPRVLDKVVNYYVQEQVFTPVSDVTSDQIFYLPALEYFTALYNSRPRGDGKVFFLQFVHYPAFAAGPYKGMVHVSDLCYLFDLDPTIANQVIDYKLNGTLWAHVDDMLKIKYSRMASVFIKRGNPNKGVSGDIICDWPTFDPEEAHYLQFSEYSEVKKYFREERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A271</accession>
    <name>A0ABM1A271_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kielin/chordin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106012099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012939323.1">
        <property type="nucleotide sequence ID" value="XM_013083869.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012099"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008037">
        <property type="entry name" value="Pacifastin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF4">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05375">
        <property type="entry name" value="Pacifastin_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046096696" evidence="4">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="115"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012939323.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="20577" checksum="4D076416CEE4EE61" modified="2025-10-08" version="1">MANQFLILCSLAVLVHSALSCTYQGKDFKIGEKFPAVDGCNECVCGAIGVLCTKMMCSFKTTVPAGKSCTVDVAGVPTTYPNGQSYKSPDGCNTCVCQDGMPICTLMACIKDTTCTDPATGKTYAPGSSFKSSDGCNTCNCFNGIISCTEMACMNTGVCFDDSTGQTYKTGETFEAPDGCNTCSCQKTVISCTKIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2I1</accession>
    <name>A0ABM1A2I1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939531.1">
        <property type="nucleotide sequence ID" value="XM_013084077.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851092"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939531.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20340" checksum="0D0F3CA183EF3EFA" modified="2025-10-08" version="1">MDMKKVSFDLEQDEKDIHFQVVGRSRTSEEEIEQLENYFKFAEVTTQGWKSSAGQEKIAMSDVKDEKEQEEKEFGGIEGPNSQYVKLMSSDGLEFIVKRDHALTSGTIKAMLSGPGQFSENENNEINFREIPSHVLQKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3D2</accession>
    <name>A0ABM1A3D2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein dispatched homolog 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939999.1">
        <property type="nucleotide sequence ID" value="XM_013084545.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863752"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042480">
        <property type="entry name" value="DISP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46687">
        <property type="entry name" value="PROTEIN DISPATCHED HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46687:SF1">
        <property type="entry name" value="PROTEIN DISPATCHED HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1334"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1369"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1448"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1487"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="3">
        <location>
            <begin position="508"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="926"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939999.1"/>
        </source>
    </evidence>
    <sequence length="1526" mass="167506" checksum="84E5B9B4D8551883" modified="2025-10-08" version="1">MRWFSVFRGGTSNGWTPVTNSDNRHGSDMDELMCMASGEYAEEDRTQGMSYPSGAVVSDYTAEDLGTEPVFCRNGRETAEPPRESLMQGSSHADGMLCKVSCACSRPKLTFPRARWYLVLLSFFTAISFIALSVGLGYYSVIVKDDLKIDKSVKSFSIPNHQAYKNFEALMLARKNSSTRMRRDTSAASQLFRSKRDLFSVHESSFKPLAGHTSFVREKRDALDTSNLNLFGLEPPLASDSDHTVLSRLKRAANKVRCLFEFEPQIVARWKMHVIYLAHGDNDTNMFTKERLETVHQIEKQIIEHPGFRKFCYRDPNLVRHIPSVRDMNGCVPLNSLLTYFYPSKNSEGKIIYDGMGTNLADVDSALKLAMNYETFYYYVDDKINRTFQKSHLLRSEVLFGAPLPGYSCAGSRGKDQDGKFRDFVITYIGLLSKASTDKVQVLYGGNEIFDYEVTSTFWSDVRLAIISLIAIFVLMLVLSLSLYLTVIGIVIIGLSFPIAFFFYRIVFGINKLGILNGAAAFVIIGIGVDDVFVFINIYRQSSHLKDPVKRIIYTVTTAGVATFFTSFTTAAAFAANLTSAIPAVYDFGLFMSLIVSSCWVSVIVLMPPLLYLHACFIEPLEMLLFSCFSCQRGSSSAGGQHHQLAHYTEQQSGENSLYREDDVAMLDVNEADGAPMWEADDDILLMDDPYSVSDNVRAEPDGTEDVDVPLLNTSSSPAFSGADQQPDVSNNNMCLGRFFQKTLMFITNRIVIRGRYVIIGFYAAVLIASCVLMSQLQPSTHPPQLFRPDTNIQRLLDLKANLSIIDTLHCDQCSGLYKVHSSSPHHVSSSNVHVPPTPPKNRHVSPLPADSGRHSTPRPPPHGDGGSRGTVAPHEGTGQGQNVPHNSDSSHGENNKASDGDASSSGDQKSVLTSMLEDTLAKLSSMYGSGSSSSTSTDSSSSSSQASPQNTHDDDTGNSQEKNKLPDSGSSSDTYDGLPPPPTGRQENNKPSSNPRTHGAQSGWDLHNDDFRKAFNNSSPPPPPPPLTPLPNQTSPHITPSPIPAVSSSPPPPPPSISSPPASRCPPQKSSAFADIIRALQETADHLYDLSKTKSTSTDENYNVCKEQRCGDLKDRPLMELGATVYVVFGVSHVNRSEEDEGHVLDQLKDTVVFDPNFSKKMSNESQFRKHLRELCTVCHVIANRTDLVKEGSAQCLPSGMYRLRHLLGTIKECQDLPNSLSIYQHQAPAHAEGGRDRNNHILWLAFAFESTTSEGQAYFQAYKEYMKWEELMRHIKTSVLAPDSPLHSMFQTSQFWTKVLMEVVAVNSAIYGLILSMLICVMAVAVFTGHLVLLAIVVVTIISMICTVVGIFYLAGWEMGAVEAVSLSILVGSSVDYCVHIVEGFILPGRRMSLPWMKSQSAKSLRIQRASLAVRHIGVAILCSALTTVVAAVPLTQTFIQPFAKFGSILLINTTVSMVMTLTLAVALMAAFGPAHYKGSWRSHATAAVVTVVVVGLSVLALYISTVLGAHIPGPSGSNLFSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A486</accession>
    <name>A0ABM1A486_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012345</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940520.1">
        <property type="nucleotide sequence ID" value="XM_013085066.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012345"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012940520.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="62284" checksum="16890740D0B4956B" modified="2025-10-08" version="1">MSNDSSVQEVPSAYGTSQEETVLELYVDLMMGGYTVPVFFSKKVFKKWFNKMCYAYFKNLSVEIASDGFVSGEQMNVTEVSHPAPESNSYECRIIPGKSRSLVCERLQTSDDCRDPTFLCFSDEECYTGQFSITWKRTQKPYLDPSETLDGLCDGTCCCHPPFGPTPVPEWGADPEGFGGPEPTDPRTTPEDGDGDGDLYRQTTKERKKETDDQDPETYIYIGVGVGVSGVLLALTVIVIVCCVVKRRGSEKEKAAAAAGMQGVANGGFGPVVQATRQNSLEAESDHTGVSIVSREAEGGTSSPSAQPITENESHYDYIDDAYFAHGAGYSMLSDETKYNHEYNPLYRSQTAPDFSLITLNRVVDSNYRYKSDTGYEKPFDYHRSGNRFSDGNGHERYVITPRSIRPAPPPTVRGGVRGNQHALRDVYTTPIHQDVTNHAPSAFSPTTPHPGIDGNAPNSYLDLSFNPALDLNHAHLQGGRVVDSRGQRFRPLSEEAPPLNPYHAYLEVLAPLAPPPRGQGRVSLPPIPATSIVDSLGPQPPLPRRQPTFHYYSQPERPGPAFIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4E0</accession>
    <name>A0ABM1A4E0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibrinolytic enzyme, isozyme C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940618.1">
        <property type="nucleotide sequence ID" value="XM_013085164.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855580"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046490545" evidence="3">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012940618.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="29574" checksum="4A0B100B23D4B78F" modified="2025-10-08" version="1">MKVLAVILLCLAASAVSEKRIINGNPAALYSHPYIASLQYYVRQWPSSGWKHICGGSLIHRRWVLTAAHCVDGLVTSDMRIELGALNLYENPNQYEETIKVANYTKHPHYRATGSGIPNDIALIYLTKDATLNKNIQLARLAPSGSSFAYTQCVLAGWGAIRTGSNPQDAETLKEVKITKITNDRCDSLWAGQAITDSHICVHEADRHTGQAPSACMGDSGGPMMCGNGHDILAGVTSWGEKTCSGTLPSVYTRVSAYLSWIRHYVGHVTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4M1</accession>
    <name>A0ABM1A4M1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glucose transporter type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940754.1">
        <property type="nucleotide sequence ID" value="XM_013085300.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846084"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF128">
        <property type="entry name" value="GLUCOSE TRANSPORTER TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012940754.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="46926" checksum="73FB9121DFEDDB13" modified="2025-10-08" version="1">MPSPIKPEVFQYYGLYTGLTPLYLSEISSSDIRGALGVLHPPPPFPPSLLLSFLLYSFTHPSSTPPSTGLYTGLTPLYLSEIASSDIRGALGVLHQLGVVLGILLSQVLGFQELLGNASSWEVLMGLPILPCLLQLLILPFCPESPRFLLITKQRETQAVEALKSLRGTADVKDDIEEMRKEARTQEREEKVTLLRLFQRRSFRMPLIISIMMQLSQQLSGICGIFYYSSKLFKWAGLSEETATHATSGVGGVMVVMTVITIPLMDRAGRRSLHLIGLGGMFVFSIFITVSLVLRDKVEWFNGLSIAVSLIYVAFFALGPGSIPWLIVAELFSQGARPAAMSVAVLVNWVANFIVGYSFPHMQNGLGDYAFLPFTGLLLVFWAFTFWFVPETKGKTFEEVTALWQEGGQRDSNSGSPKEHSHLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A549</accession>
    <name>A0ABM1A549_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106012483</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106012483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941014.1">
        <property type="nucleotide sequence ID" value="XM_013085560.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012483"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="170"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-turn-helix" evidence="3">
        <location>
            <begin position="358"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012941014.1"/>
        </source>
    </evidence>
    <sequence length="562" mass="63723" checksum="20E68725B150DD08" modified="2025-10-08" version="1">MIDGNQFHFKSKDNLNGAERKALHDLMHDNDLTIREADKGGSLVVMNTSDYKHALNIMLNNPTLYKPLTSDPTSSHLKAIHKQIRTLEQFKVISPEIHKSILHGEVSCPHFYGLPKIHKPNKQGSILPPFRGIISQIRGPTTRASYWLDSIFKPLVPDFCGNHWVKDNLHVLQKIKTLNEKRQITDNTNILAIDVVDMYNNIPHKEGVEACRFALASLTTYTPCQIREICQLLELVLTLNNFSFNDQHFLQLTGTAMGTPVAPSYANIFMAEFWRKNIAPLPNQPFLVMRYMDDIIALHDGNSQQTHQFLSDINSVHDTIKFTHSNPGKSTAFLDLSIHLLNNNIETDLHLKPTDSKRYLPPSSNHPKHIFRSVVYSGALRLRRICSRDEWFNARITDFRENLLRSGYQNSFITPIINKVCKLRHKDLLSYKLHKPHQKRPFFVTTHHQKLPNVHNIHNQNKDILEKSDKMMKCFPQPPLIALRQPVECRNVVSIRGTGRGTPTTATATGPAVSPPTEDIIQSDSGAESQSIETPSGRLSTESADLKRSLIEYMSGKKGGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5P5</accession>
    <name>A0ABM1A5P5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenosine receptor A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941320.1">
        <property type="nucleotide sequence ID" value="XM_013085866.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859957"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="60"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012941320.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39970" checksum="4A4B8399D09759F6" modified="2025-10-08" version="1">MSFSNLWVNNSTNSHDDSVPITTTPSPSHYDIVSDEQWYIVQVVNGVVICGLLSLFGVVANIINIVAFAKQGFQDSINISLMGLAVADLCSLVAMMWMSICVNPLFYLSDLPFEPREVMHLTGATPRYLGAKISTFITAFITFERCLCIAAPLKVKTIITPARTKIIIISIYITMSILLIPFCLGNRLEWVFDFTMNATVLKTTFTAERELLEAITYVTQGVFTTTLSFVFVICCTIVLVVKLNSKTKWRQATAAKDDRAAERVGVKDQKVVKMVTFIAVIFIVCSLPPTILFFYMLFDKDFHIDGVHQNLFLAVFFSSFITETLNSSVNIIVYLKMSSKYRAVFMKIFFNKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5W0</accession>
    <name>A0ABM1A5W0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860271</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941425.1">
        <property type="nucleotide sequence ID" value="XM_013085971.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860271"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941425.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18380" checksum="4959FB8F0720A895" modified="2025-10-08" version="1">MTLHPQAAVTAVLSKLCRIPVWICLLAVLEFTGVTGKLCWYQKSVYNPFQSVYDKVPTSEECQWGCCNHRNTPCCSAPLSLIVGSALGGALLLAVLLIIVCCCCFCRKQTRQEERRRGTAITQQTSVVFHSAGSGNNEELDTTFDPPPSYEEVMRGEVNQGFKPDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6C9</accession>
    <name>A0ABM1A6C9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012651</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941677.1">
        <property type="nucleotide sequence ID" value="XM_013086223.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012651"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47824">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47824:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941677.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54421" checksum="6D8AE5C09A7B8202" modified="2025-10-08" version="1">MSACVNAPMPPCGPLEIVFSFDTTGSMYGYLDQVRGRLQDMIQRLQADIPAIRIAVFAHGDYCDHQTYVTKWEDFSSDVAKLCSFVSNVERTGGGDAPECYELVLRQARTELSWTPGSRRAIVLIGDDVPHEADYYLNTDNIDWREEIRELASWNVTVYGVQCGNNRDASPFYKTISAATDGKHLQLEDMGGIFDVMMAVCYREGNDTAKFANYEMEARARAGVIGPDVDAIFKSLRDEADGTSTAGPSVPAPSVKLAGVPKPVTLKRAGSSMEKLTKKSSIHAPKAPKAMRLVKPKTSKKTAANKAEPPTGLDKFKLKNLPRLKRENVPETNFCLRSMTWTPWVTAFVPYVADTKMVKGDWVKRFGRPGYRLTSLAPRSGQDSSGLRLFEVAVETSNKRRHVMFSRFSSRCMSTQKWQRYLLSSWCRSQVDNALGQGCRVMVRHCLLEGKSQASSVKKDIRRYDYAWSQAGGGVRAVVKRDTTLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6E8</accession>
    <name>A0ABM1A6E8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cholecystokinin receptor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101861754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941704.2">
        <property type="nucleotide sequence ID" value="XM_013086250.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861754"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="141"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012941704.2"/>
        </source>
    </evidence>
    <sequence length="221" mass="24346" checksum="E405726A5EA55085" modified="2025-10-08" version="1">MAVLGDVSRNAREKSPDPRLNSKTTEMANILTYDVSESEYASLQNETFTNNDDVNGDYSSIFQTPAVTPVLQASANNNNNNNNTVFIEENFNLSTLLGLDMNDSNSSVGNVTEVPPYNLPRLSVEIQIALYSIIFVLALVGNLLIIITLIQNKRMRTVTNVFLLNLAISDLLLALVCMPFTLVPVLLMDFVFGSFMCVFIRYLQAVSVGVSCFTLVAISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6M8</accession>
    <name>A0ABM1A6M8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Retinal homeobox protein Rx2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941849.1">
        <property type="nucleotide sequence ID" value="XM_013086395.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861226"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043562">
        <property type="entry name" value="RAX/RAX2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="218"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012941849.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="46689" checksum="28AE43EAEA9F9B60" modified="2025-10-08" version="1">MMTGVGAQTTRFHSIDAILGLSGSSSGEPDASFAHSSLSENDRQIYAESCGNLCNRNMSQELRLDPNDPPRQDSTSSTLTTVPSTLMADSGHNSIAPDPAVSSHRPSSPISVSLLSEQPRSRTNTEGYSPRQGMNDTVGRRFDLTNGSYVQHHSSTGEEVEDVDEEEIDLTTVSAGGTKRNRNCDRFDSMTQQRNERRGEDEDEDSPVDHEDKTKKKHRRNRTTFTTYQLHELERAFERSHYPDVYSREELAMKIKLPEVRVQVWFQNRRAKWRRQEKIDYGKLPDGLAIPSLPKLQTPVSLTSAPLPLDPWFTSPIVNITTGGEMIPQPPSALTSLPAMASGTFPDYLSTAMTSRCNNLSSQFHTLSGMFNPLLARRAGIHCVNGRDNSKHSSIASLRVRAREHLETIDRQIEGGGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA37</accession>
    <name>A0ABM1AA37_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943734.1">
        <property type="nucleotide sequence ID" value="XM_013088280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013203"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045704049" evidence="1">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943734.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15025" checksum="524D1798E10DE978" modified="2025-10-08" version="1">MESTTFSLALLALLATTALSGPKSPPATPSPITAKDKAKVDDTVNAVKDVPSSCCSSIVSFSDMAKGVDGAKTKQQKCNVIKTYLNTCKDTGAGCSAGDTLQKARKQTAATCGSPLLHASVLLVSVMVVMTSHWSKKSLMRWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB91</accession>
    <name>A0ABM1AB91_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101864485</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101864485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944389.1">
        <property type="nucleotide sequence ID" value="XM_013088935.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864485"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="6">
        <location>
            <begin position="301"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012944389.1"/>
        </source>
    </evidence>
    <sequence length="915" mass="100646" checksum="10E663FF6C205BD9" modified="2025-10-08" version="1">MGDDVTAIATNIVTAIDTERTDVICSVLSELGSKKYNHDPDLLQKVLNGLHTNCGTLLHYATKSGKVDKVRTLLAGGADPGIQNKDGLLPLDLASDAIRTVYNEELLKATAQSNIGRVCQLLAAGVDIHLTDSPEMLNTPLHWAVCHGNRDMVQCLCARGADLNIYNTRGLTPLHEAVKRGDAGIVEELLNYGANGDLQVTSGENVGQTAVDMAEGKESVMQVFRAPRELPEPISNMNHYFDSKANLVRFDSLTSTDSILGNGDETLSSPKLTVPKANGKVRFETSSPLPSLVTDEKLFLVWPAMQVVKQGGGNPFTINKALPVFVSPNHDAASAGDMAYLWNLRRPLLESLGLDISINLLTPLANLDSPHILCHLNPRLSPQPGFYRLTVTPKQIKILCGSLESLSYAVSTVLHLMTLYKEEESITVPSLLIEDWPDLAYRGVLLDVSQGRISLMDSLEEYLDTLSLLKINQVYLYTRFHSNLPPQWQCPHTRSEVLHLSEFCHKRYLQLVPVVEVGPKVLWEDLPKLYPVFQDFLACFPHAQFVSAGPRLSTFLLDSSEDNLSVGDVQRFLPIASNQTLQLCGYPLHDLGTSMLQQLPPGIVFKEYAVKADHDYSKYCAPLAQLGINYFVCPGTAAWNSLAGCPEAAVGNIFSAAMNNEGALGMVVCDWTGKGHLNHQLFSWPGIITAAGLGWNKNTQKDYLETSLPALLNQYVFRDVEGALGSVVMELGRAETYAIRRSRNQPGEDSSDLPEEHGSILYRFLTHPDAVPLEFLSTDALQHVTRHVRKCQTALPRVHCVCAMGEVLKSEAQLTTELMLLACKVGKALVLAGRKPNSQSGYDVVNFGISNLTVTTRTDLANRLLELMKQFREVWTQRANPDLGLSDSVQRLRSLFKVLLPNTDHSSLLNSEADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACV2</accession>
    <name>A0ABM1ACV2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101846545</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945261.1">
        <property type="nucleotide sequence ID" value="XM_013089807.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846545"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945261.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12438" checksum="9E24953FE883699C" modified="2025-10-08" version="1">MGKVTTGASMKRKQEGAEDTVPVTQDGNHRQRDGPCGKKCFVVTAVALFLFLTFVALPAGAFLIIHGRHQDSLAFQLGGAAVVCVPILVGVILTIVFCARRHRRKATFTSVSTARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADJ9</accession>
    <name>A0ABM1ADJ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101858821 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101858821</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945634.1">
        <property type="nucleotide sequence ID" value="XM_013090180.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858821"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01221">
        <property type="entry name" value="PH_ephexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11793">
        <property type="entry name" value="SH3_ephexin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047271">
        <property type="entry name" value="Ephexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
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    <dbReference type="InterPro" id="IPR047270">
        <property type="entry name" value="PH_ephexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845:SF5">
        <property type="entry name" value="EPHEXIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="8">
        <location>
            <begin position="1703"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1924"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="2059"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="582"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="670"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="920"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="939"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="1088"/>
            <end position="1508"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1606"/>
            <end position="1662"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
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        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
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        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
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        <location>
            <begin position="814"/>
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        <location>
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            <begin position="909"/>
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            <begin position="955"/>
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            <begin position="1041"/>
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            <begin position="1138"/>
            <end position="1151"/>
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            <begin position="1188"/>
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            <begin position="1223"/>
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            <begin position="1283"/>
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        </location>
    </feature>
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        <location>
            <begin position="1298"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1358"/>
            <end position="1367"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1606"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50002"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50010"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012945634.1"/>
        </source>
    </evidence>
    <sequence length="2149" mass="237310" checksum="3BF0932DF29F97BD" modified="2025-10-08" version="1">METSDLPSQVNEDGCDPPSSVEEVRKKRLAYFSANRTSTDEKKECTYEPEEQVWTAGQASTVFSKKTSVPVPPGNDSGNPEQKQYNATESHLITSKNSQLLIPKHSSNYASQSHYYNGGNAFASNTQATKVHDSISYPQPHQSFEPNMRPDGHRYPLGMNQLSIDRSEEYDRISVFNSVADYNELGLSTHRPESTGGMSDRSISREFYKSYEQGRTAEDVFGGKSAAEMRAALGDRGFEELMLKVNQNLGVLQRGRMAVHRAHELKTSGDQTELKGQGELPSRSSSVDSMEKRQRMPTALSPRHRIHSSNSQNSLRASTVTRNINQLKDGEKEVLTLVRNYDQVTVPRNTKNTYSADEIYREAFGTHPDLSSSLDSRPAYMSAYHQAWGPPWADRNTNSGAQSDRSNPPLSPKRRLSHDSVPVGSQPGFSPYHPYHQGPFSYPPPPVHHPPSYESHFANGIPPPSPTQAVPASPYSPHDGAFYFSHQHSYRSPASGQHPHHTMEPQQFYSAAISNQSFMPPSPSAAPPSSVPPFFYPPHQMSNPQVLKFPTNGVPLHLPPPPIPHPYKHQGNVSQYSLPHQFAPSSTRRGSLTHYGQSGFQGQEGPVSGFLKVPHPPPNPPALKGKEELSEHRRTASSGHHIVPQSGGEEANSYNLQRYFSSLELYDRAATDPSPAPLPNTSRSVEGDYCKTENDDDDTQSAFTSVTGVTTASKAGGVTQRLLDLGMDLDHLRHLRVVDKKADQELEDLKFERLSKGIRYCPECGASNKAYMDWCTECGEVIIGVEPTLPLSKKKQIEEKERRRKSSSNKIVAGQNQSKLSNGNGSSQKIEEVEGAVTSSGYFPKDSPESGRGLSLSSSPVRYRREQEEVGEPKDSGRASSGDMRERAVHSQSDGELPENGDCEGIEQENAREADKMNEDFYDQISDPVLKEFIISYRNRQNSKDVSDNGGVASFSYNAERTSPTKAKYQSAHLKNEKKSQSEWPSSTSNIDWEASNSVTKKDVSGNKSMAENVRLPAENSTACPNGEVEIQEKESLPSKKVSKKGSGKKKKRKGVMMDVEIFGYEETRLSRDSTRGHNLVPLLNLACSSDESDDDDDDDDDDDDIYEKVAHHLQRAPSSTDGEQEGDAVRSPGRRLGVYRKQKGSKKKEKKSTSSAAEVPSDSEEVVVHSDGEGGWENSDGSSSGTEYEDVEPDKDGEEEGEVEECLYEDLENFSQPSSKTAKNKTLTHKLKNIFGNKKGKGKKNKQAVDSGVSAGTDSEGDFIDDADDVDSDLAENLSRTSSERSGGRGINRDDNTNTASNNISTSASTAATASTTTVANAEESASVTLRSQTSEGGVPNMASSSSSSGGGGGAGPPLPPPPALPPRTSKALSQVAENSPPLPPRNPSLSNKATLGINLDTVVPISPPAHHGSSKSLDTRKDRFSYGQGSHDGSETGSLPGKLEYIDYDPASPNTLERIEKSEPVITVELRRGGQNKSGSKKKKRESSRKSSGSSRPMSSASTASTSSSYIYPDINAFPELRAYNNDDNLYVDLEDEHIYGKASDIYVSRFESEPLYQWYSKDKMIQVIRSDKSDDLSDEEYLEHGHADEQSIYEDVERLLEESSSNSSLAATSNSSSGSGGGGGGNGGGGGGGSSSGKSAQNNRLSVGGGGLSARDKPQRRSVIEDVFKNGGTLHRALWCQMPEVVDSGILKNISDKEKKIQEAMFEIMTSEASYLKSLKILISVFLMAPEFSVDMSDRSVITYRDRQVLFSNIGSIKDISEGFLKDLESRWQESYFLNDICDIIEKHASEKFEPYVRYCSNQLFQDRALNTLKQRPEFNEAVKRLEQHPDCQFLPLGSFLLLPMQRITRLPLLVDAICHRLEPGSPRHLSGQKALYSLRKVAKRCDEAAKKMQQTEQICLLASNLEFKIKEFPLVSASRFLVKQGELTMVKSDGTTRKPLSKLLGHNKENIYLFLFNDILLLTKKKGVTYQVRDYCQRNSLHVEAIDHPDKSRHIAPGAAAGIPNVLFLAMLANHENKQVELVLSVKSESERTRWIDAIMPTQSASDNERIYDYWDCPQHQCVRKYIAQQPDELNMEESDVINVTRKMGDGWCEGERIRDGEKGWFPASHTEEINNSHVRARNLRLRYRLMIASSQEYAPVDYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE27</accession>
    <name>A0ABM1AE27_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxisomal sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945924.1">
        <property type="nucleotide sequence ID" value="XM_013090470.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012945924.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19367" checksum="5B07446FFABE3F86" modified="2025-10-08" version="1">MPIRVSALYWKADTSRQELHGTRSQPCIVDSRDNDNRSIHVYSLPIDEYPGLVKVALHHGADIDPNYRDVVDTDWIERVVGDKISQLMPHVDGRRPVQKEYCIYTNTPDNHPFIDRHPRHKNIVICAGFSGSGFKLAPVVGKAVTQLLAGQTPPYDMAPFRLDRFAPKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEC7</accession>
    <name>A0ABM1AEC7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">rRNA methyltransferase 3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101859618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946066.1">
        <property type="nucleotide sequence ID" value="XM_013090612.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859618"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF2">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="4">
        <location>
            <begin position="214"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="4">
        <location>
            <begin position="386"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012946066.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="48841" checksum="C2E02A3A61403888" modified="2025-10-08" version="1">MSLASKLIFNTYRSTSLGAFCRSYSRHKRVTKRKDDHASDPRKSTRYPFVPGDPVQGDAIRSLAAGTNIAVRKNPKPTTTRTIQKIKSQTNLFRTDSGLQYEKIMEGDYRLGRTILAAKAGKSQGQDDTIVLEGTRLIRDALLLGAEPKFLYFTDPAVLDKLPAECLAGVGLMKILYRDMKTWSDTTTPSGLLGVFKKPHAGEVSVPRDQTLPITVVMDGLKDPGNAGTIIRTAAAVGCERVIAVRGTVNIWEGKVVRSAMGGHFSVPLHWGLSWAEVGGYVAEDSLVLLADTQDGRMLDRAFDHTMSLEELDKLGVQDEGVYGSDTDTEATEQSVQKAERQRERWAYPFHKVPMAVCDYSQLQLPPGGWGVGGVTPHTPPTVTPTPPSITLVLGGETQGLSGQAKKFAFDRYGQYVTIPMCPSVDSLNTAVAAGVILYELRRRLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF33</accession>
    <name>A0ABM1AF33_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable serine/threonine-protein kinase ifkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106014012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946456.1">
        <property type="nucleotide sequence ID" value="XM_013091002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014012"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946456.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="35204" checksum="16A414ED87893CE7" modified="2025-10-08" version="1">MSSKRKNTPTKLSKEERLSGHTSPGLNACSPDDLDLDSDTDGEQDRGQFLQEATTGHSKHDTSPQFSSEAGRDTTVRGEGESSDIVGLEEDEDEEGSERQHFSEPLGESVNFDIDEGEEDAASIRSAGATGAAADLGGADYVSDSELDTVRDPNPHGLTSDSNGAALIASSSTASLTSSTNKSTSLSSTSTAGSFNNNNNNNNNTNNNNNKRSMETVLRKLSSKASDVAIETAMASSDNQGERPMSPKVMDTVQAVLAGEATLSEKERQISEMINHLQNIRENLSKQKDQEPRGRQSPEKPRRQGKEKDRVLPGDGPARYSETKTRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFH4</accession>
    <name>A0ABM1AFH4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 49 member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106014128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946642.1">
        <property type="nucleotide sequence ID" value="XM_013091188.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106014128"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF27">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012946642.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20911" checksum="7A55707A1EC3AD47" modified="2025-10-08" version="1">MDFYATLGGCTAGLLVSRFVDFFTRQMKLCLLLFYLLAGLAALWLTLLVEDVLPFDTVSVYAAIVIGGVFLDGGAPLFFELVIEVSYPVGEGVTSGFLQMLTAFSGVVFLSLLQIESIGKQWMNWCFFGCIAAAVPLLYFIDTVYGRADIDDMEVDVSADVSVDVSVDDDPDVSAITGGDYPEKQSLLNGSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFM9</accession>
    <name>A0ABM1AFM9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="7">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101847403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="7"/>
    <dbReference type="RefSeq" id="XP_012946713.1">
        <property type="nucleotide sequence ID" value="XM_013091259.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847403"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="639"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012946713.1"/>
        </source>
    </evidence>
    <sequence length="704" mass="80685" checksum="BC7CDE62DBB90888" modified="2025-10-08" version="1">MALPARRRNSFYRTLKNVEPDLEDLVFDRGASATAQNKWLFEIAWEVANKVGGIYTVIKTKAPVTVEEWGEQYCLMGPYNEACVRTEVEILEPHHHVYRETIGNMRKAGIKVYFGRWLIDGYPKVVLFDIGSAAWKLDEFKHELWETANIGIPWHDRESNDAVIFGALVAWFLGDFIKNTQGEPMVTAHFHEWLAGAGLIYTRTRKLNAALMFTTHATLLGRYLCAGSADFYNNLDKFNLDKEAGDRQIYHRYCMERAAVHCAHVFTTVSEITGVEAEHLLKRKPDVITPNGLNVVKFSALHEFQNLHAVNKEKINDFVRGHFYGHYDFDLDKTLYFFTAGRYEFSNKGADMFIESLARLNYYLKSCNSDVTVVAFLIFPAKTNNFNVESLRGQAIAKQLKETVNTVQNQIGRRLYDICLRGSLPSGDDIFTQDDVVKLKRCIYAAQRNSLPPICTHNVMDDSNDQVLNQIRRCNLFNNRHDRVKIVFHPEFLNSTNPLFALDYEDFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSITTNLSGFGCFMSDHIVDPKSYGIYIVDRRYKSPEDSVRELAQDMFDFACLSRRQRIIQRNRTERLSEMLDWRNLGIYYRKARNQALTKVFGERADVDATSDKKDFRMMKPASAPPSPSLSRASTPQVGDGEEEEEDDTHLYDDEEDAGIQFKAEQPKQAVAVEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFV3</accession>
    <name>A0ABM1AFV3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycine receptor subunit alphaZ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101845828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946833.2">
        <property type="nucleotide sequence ID" value="XM_013091379.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845828"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012946833.2"/>
        </source>
    </evidence>
    <sequence length="372" mass="43226" checksum="DFAF97EA1CC2B20F" modified="2025-10-08" version="1">MGDMKHQNSVLAAIMEKEKRKVMIKSVFLKIEDIDTIQETFSGLVFVKARWREPLLDSSTSRDISKINWDGLWNPKIEIHNVKGEAKQQIWKDLQFGPGGEAFVLEKRRVKGVFSESMELQEFPFDIQDLSLLITSNHQENEVDLEEDQEDISNVVTQSFVDESEWHLKKFVQCEPRVTEDEFVQNKYRKPGLFFRCCVIRRAGFFVWNIMLIMSIISALSFVTFAVSRALPQNRIQLSFILLLAGVTFKFAASQSVPKISYLTHLDRYILGSMIFLFLVAVWHGVITRLDHNASDEIDMYAFIAFIILYVVLHVVFLVAMMIRGFSRRRDVHKREQEYLKRLAAAGTAMPPTTRRKRRPFLHRQSRIGMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AG61</accession>
    <name>A0ABM1AG61_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849591</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_012947012.1">
        <property type="nucleotide sequence ID" value="XM_013091558.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849591"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 8 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="404"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012947012.1"/>
        </source>
    </evidence>
    <sequence length="716" mass="81405" checksum="257E3C5C2F461202" modified="2025-10-08" version="1">MTKESKTMSTIRRRKGKQVAIALQKIREENPKPVVASEAEIAAAEVEDHCYMFDDKVLGPIVLRRLMSNSRSLFLALIVIRCANALLIQTQFVPDEYWQSLEVAHKMVFGYGYMTWEWREGLRGYSYPLVFATLYKILYFLGIDSRVMLIKAPRLVQAVIAAYGDLHLYKLSSRLSGRATAQWSLLCQLLSWFTIYCCTRTLSNSTETALIVGALSYFPWPDSASKRNDVYKFLILAALSVIVRPTAALIWILLCSWHLQRLYGSMAFQSVFNAYVFVGGLSFGGSVVVDRIWYGHWTVVHFNFLWFNVVQGGASIYGTHPWHWYFLQGVPVVMGTLVIPFFLGAWRAKNKVLLWIILWILATHSFLPHKEFRFILPAVPLAMHYCGVYFQHLCSKPPLRKFKTPKSMESETVANTSSDAEKEDFAASASESPPSEMEGKEKQNSETDDKEKTVTLEKKDTGKENIEETKSGVKDAGLNLSSESAPKEVSDTDGTGEVKSSPKSLEKEEGPGSNESLTAAKEGILKEENERKDRVETMSPSMLRDHVHRHNLLKAKVLIGLLAVTNLLPALYFSLIHQRGTVMVSKFLHQAAINNPGMEVLFLMPCHSTPYYSHLHQNISMRFLTCEPNLQGLSGYEEEADRFYQSPQDWLRSEYGRGKRYWPTHIVYFNSLHKQISSLLTQSGYRMCESFFHTHFPEGRVGSSIFISCRWSVKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPG9</accession>
    <name>A0ABM1VPG9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Retinoic acid receptor gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101846563</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824311.1">
        <property type="nucleotide sequence ID" value="XM_035968418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846563"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06964">
        <property type="entry name" value="NR_DBD_RAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047159">
        <property type="entry name" value="NR_DBD_RAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF9">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="144"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035824311.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="45892" checksum="B4E3CDD40BDA5277" modified="2025-10-08" version="1">MQSMGKESVSGGSMFEPHSGLYSSHHTSNLLSAETRMSPPLPPRVYKPCVVCNDKSSGYHYGVSSCEGCKGFFRRSVQKNMQYTCHKDKNCVINKVTRNRCQYCRLQKCIIMGMSKEAVRNDRHKKRKQKPESTSGLSEELTEDDQMLIQEVLDAHRDTTPNSQNGATLPFSSATADLVGTTTTAATTTPSKATSTSESRSDDESSGSSGVFLWEKITELSSAGIVLIVDFAKKIPGFLSLSTSDQITLLKAACLEIMILRISIRYEMDTDTMQFPSGLALTREQLQKGGFGPLTSTIFSFAASLKRMDCDETEYAMLSSICLISGDRSGLQDTEKIEQMQEPLLEALKHYIRSRRPDQRHIFAKMLMTLTDLRSISVKGAEKVLHLRVEKYAPIPPLMVEMLERVENVCFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQW6</accession>
    <name>A0ABM1VQW6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Early nodulin-75-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824808.1">
        <property type="nucleotide sequence ID" value="XM_035968915.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011360"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824808.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25936" checksum="B2D57DA29C07918A" modified="2025-10-08" version="1">MTTRSTPATTPPEITITVTATTSSPNTSPYHQVQYPSKPVYRPTPVYHHEQPEYQQPEYQQPEYQQPEYHQPEYHQPEYQQPEYQQPEYQQPEYHQPENQKPEYQKPEYHQPEYQHYGSSEKYYKGEAKAEQDRYYYYNSGEKVQYRPYNNFDNQKRYEEPVHGVQVTTVYKPVYKPVYKPVYRPANSYYQYLKPSHVPNTEETKVESNQRWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VR34</accession>
    <name>A0ABM1VR34_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864606</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824876.1">
        <property type="nucleotide sequence ID" value="XM_035968983.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864606"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824876.1"/>
        </source>
    </evidence>
    <sequence length="620" mass="70802" checksum="15788D3B3325D953" modified="2025-10-08" version="1">MSEADKAVLSLCEEFWQWRLKESPELASFSGFHQYDDQWDDISEEAYTRRDNCVQEFVKKAKALNVTECSPEVALSHTLLCDVLDLYTTGSQFKSHLCPINYLEGIHKESNLTISYMKFLSEEDFDKYISRLEKLPSRIQQVTALLKRGVEDGVVMYKCSVAEIPNQIEAALNTELDKLGLLEPLSKEHKDIPAESISKYSVRAKDIVMSEVFPALTELRDYVKETYMKKTRPCAGINTLKNGSAWYQACLNHHLSCMMTPQEVHEIGLKEVQRIRGEILKLAAKEELGGTFPAILQAIVKKQENNFQTKEDILNYVKNLCHERIRPKLSTLFKNIPDLPLSIVPFPDYMKGGPAGYYLSGTPDGSRDGGYYINIHNPKDCHQFHLPALSLHEGEPGHHLQSTNALAATHLPDFRRYCEDSKYYLSPRNFPFYTAYIEGWGLYSEALGEEMGIYEDSFEWLGRYSFEIFRAARLVVDTGLHAFGWSKEKAVKYMIDNSLEPESDLRQEVERYITWPGQACAYKIGEIKIWELRRKAEKELGDKFDIREFHDRILSSGPMSIPMLASIVDSFIKENKGEPTPMIEEPSNETPSSETPSNETPSNEAEAPMIETPTNETEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRJ9</accession>
    <name>A0ABM1VRJ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RanBP2-like and GRIP domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825041.1">
        <property type="nucleotide sequence ID" value="XM_035969148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846497"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBD1" evidence="7">
        <location>
            <begin position="1358"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="1548"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="7">
        <location>
            <begin position="1915"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="7">
        <location>
            <begin position="2258"/>
            <end position="2394"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="7">
        <location>
            <begin position="2866"/>
            <end position="2981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="805"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1195"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1256"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1321"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1577"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1620"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1794"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2396"/>
            <end position="2420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2792"/>
            <end position="2818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2841"/>
            <end position="2864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1256"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1267"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1326"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1638"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2405"/>
            <end position="2420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2849"/>
            <end position="2864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035825041.1"/>
        </source>
    </evidence>
    <sequence length="3005" mass="325555" checksum="27A23A033112C7E1" modified="2025-10-08" version="1">MFKRKQDVDKHVSSILSRKRDEKERNAQGFQIARLYMDIREFATAKKYLCGFLHAREKASPQAHQLMGEIHEALDEKEAAVESYKRALDLGGFGSTNRQLILKICELYCEIGSDPQRMKYWLDKCEEFFPKSEIVFNLKSKIASSNASGDSVEMESLITSELIKRPTDLNLRIKLLNIYTESQRYEEAYSAAVSTDLTTAFVGSLHWFEVLVSVFQGYSKQVKSAKEDRDFLLHYMHVLRNVAFLQLSCKDVQSCSRALERFDKELKVATSLRNEDEAWTSFVKEMKGQIYYLAGLLLLKRSHSGAISWQEGNQLGGACFLASSVIDPLDAQCPWFVRAPQNYSKFYQWWYHQSYDRLSQVGHMLQQLSQSDIVQWSKSVKQRTMTATGHQKIFRALYSLQDQEAKQEDFFLYSTEDLVGGPALQEPLSARQLVDIDRVASQVHLNKLSNLVWLCLQRYSSDMNAQPNYHFSLMENIQFSTRNLDSGAGESLCQLDILVFLIAAVRCAATAVSENIYHCDEHAGRPKLLPVALCKQLCSQEQEEWWSTAVKFCTNAVKTDFARLRRVLVRGIETVRLIGSHGMSVSMIAHIARSLDAKIQSLKDSEYGCRCPVFELAALENRVAFYWEKAKKAIELFQRSQHIPMPKNRLFKEVDDIHLPPTLLEHYKTEAGFALSLSAMRNGQFEAAIEGFSKHRSPWAKFYTAQIYKILAEKANDEDAVVNSKSEALFVKARDCLYDVKDRLAGDTTHELNEQVDLELEDVISRINMLTWESHETNGSFATPNKTPVQVSSLSSAGLFSSNANSVSYGTPRPKVFHSTPRMTSATEPSESEAEVSVSSTSEHLADTSRPRPSPERLDSQIKSLSHSQASLFKMVLDRNEELILINGKMMEELRLNNAQLKTVLTENKTLMGEIKTFLCENRETMKQLKKEFASLKPSLVPLAPPALPQVPVPPVFMPHPSPVPPPRGPFPGLAPQPPMMPAATYSYLLNSSVPPQPPPMGPGAPQYRPSGLPGQQTPTVGKYKAQMDDEEDEDDEVNSADDSAALFAEYYDPDFTQYYTPDSQIMQDWSLNSRPTVDPPPSMPMPGPPQMQPRMSMPPAGYFASALRGQSLQYAQNSPGPAGMKPMAYRPGFFSSPTSTVPPQPNIGMGAVGGAPPVATQNSPLSGMVMPGSSPSTVLTTEIPGQKSVMAGVSKSDTAAGPPVNIPPGNAPDSAAKSVGFNIGGTPGLMGASSSSTVQPGDGKEAGKATFAGFTFSSTPNISASTDKERVKAEAHKSPQAAAGDAPKPFSGFSLTPSTGVPKPELKFGALPALDASKNLGSVQKSPSASAKSPGPAPKSSGGPDDEVVEEYEPNVDFKPVISLPELVNKTTGEENEVTLHVDRCRLFRFDTEVKAWKERGVGEMKILKDKKEIKFRIIMRRDQILKMCANHFLNADMQLTPMSNSDRAWCYSAHDFAEEEMRMEQLAVKFKTAEKANAFQTIFEVCLSQLKEASKGKVSMPISTPDSSVVKSPESKWDAASTSKAAPAVAAASAAPKSLTELFKPKVGSWECDGCLVRNAGDVLKCPACATLKPGVKPDDLPKEQPSSSSFSIASLTSGSTGTGFRFGSGSVAAGATPGPGAVKFGGPPPPGSGEAKQEDMPKEPGTKSGFSAGAFSQGPSATGFRFGPAALRGGGFTFGAPSALAESTTTTDAAAATTTSKFSFGQSAATAPVGGPVSFGSGPVTSTPAAAAAAATKPSTTKVSPFVVSTAQQSGGFVFGGSALSSLSGGATSSVTTTSATSSVGFSFGPKPSGFSFTPPKEPAGNQAEAKSKSSQPDGGLLAKLLTSDDSTADEVLGITSKPADSSTGGFNFSMAAKPTSFGGSPSGGQTQSQGFQFSLAKGQGGPAVPSSPEVDEQGLYITKEGDDSHIHFEPVVALPDKVEVKTGEEDEVILFESRAKMYRFVSGEWKEKGVGVVKILEHKENKKTRLLMRRDQVLKVCCNHMIDPALKLEAMARSEGKAWTWYAMDFSEEEGKMEQMALRFRTAEIAGEFKNVFDQCKEKGKTTPDKSGSAAQAKISGDANSVKKELFAADSQTGEEDDDDVIFVREEKPTDEQVEKARRYLLPDNFYLYESKPPCPGCIGCTDGEVPVNVPAKSKPTVPTGPGFAFGQSSPSLFGGGANLPNFASLTSDSDGEKSEPAVVFGSKTSMDFSSLASEGETRNVFAVKQGDSSSPFKFAGAGQQLFRPGGAFAQAEGGEDGNDSGVVPSEDVHFEPVIPLPDLVEAKTGEEDWSALFCQRAKLYKFDQDAKQWKERGIGEMKILSHNTEMMFRVLQRREQVLKVACNHLISEDMKLKPLATSETSWCWLAHDFTDSEGQVEQFAVKFKNKDIAQQFKEIFEKCQEDLRNCTSAAKPHHQHSADTAHAPKDQSVEEDTKLKHSVHPSCDLSPAFYETVMSSLKVTPLGDKGNVYHTKALNVAGEDTMTATSFTQLGGKDAEEVMKAKNVTPLGDRGNVYHTKALNVAGQDTMTASSFTQLGGKDAEEVMKAQNVTPLGDKGNVYHTKALNVAGQDTMTASSFTQLGGKDAEEVMKAKNVTPLGDKGNVYHTKALNVAGQDTMTVSTYSQLGGKDAEEVMKAKNVTPLGDKGNVYHTKALNVAGQDTMTVSTYSQLGGKDAEEVMKAQNVTPVGDRGNVYHTKALNVAGQDTMTASSFTQLGGKDAEEVMKAKNVTPLGDKGNVHHTKALNVAGQDTMTASSYAQLGGKDAEEVMKAKNVTPLGDKGNVYHTKALNIAGEDTMTASTYSQLGDGKDKNVKSGPAQPVAAPAHGASPNPQQLFESFSGSGVPPAAARAPMWSRVEETQPDQEEYDYDEVEDDEEEEERILFEKRATLNSYEDGQWNKLGVGTLLVTYNEDVNGNMVSFATDDGVRGCSHIICREHTITHEPTGRSCEWSPLDYATDEAVRKHLSAAFSSAAAAAEFAKIFIEGQRLAVDSELSENIGKEIDVPEIFSHGEPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VS48</accession>
    <name>A0ABM1VS48_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synaptic vesicular amine transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC106011549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035825240.1">
        <property type="nucleotide sequence ID" value="XM_035969347.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011549"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035825240.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12304" checksum="7B98C0476D4C6408" modified="2025-10-08" version="1">MPLLALLVDVEHEAFYGCVYAIAQLGVCLAYSVGPSVAGLAVKAVGFDWLMRSMAIAIVLYCPLCVLLRKAPGQEEEDILLPKRGESSPYTEDKERNDEGNFSYGRLCEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTG6</accession>
    <name>A0ABM1VTG6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC101851409</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035825708.1">
        <property type="nucleotide sequence ID" value="XM_035969815.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851409"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055163">
        <property type="entry name" value="ALK/LTK-like_GRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF604">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12810">
        <property type="entry name" value="ALK_LTK_GRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 25" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045900436" description="receptor protein-tyrosine kinase" evidence="21">
        <location>
            <begin position="26"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="23">
        <location>
            <begin position="254"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="895"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1190"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1349"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1235"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1275"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1351"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035825708.1"/>
        </source>
    </evidence>
    <sequence length="1399" mass="153160" checksum="0E219B1815E9CE51" modified="2025-10-08" version="1">MVPRIIKRWPLVLCWIVCMQTMTSSVYVDSEISSDVHDFEDANDNWTTLKDYQLVRVQAKMNEVNGAPSIDATLGTGQGHYGYAMYNATNHHHVLFSACQPPSGAQCRLNFSAVINTKHSLRVGSTLSCDACLNSKGNESWKVVEVAPTEPEKGWQHISVELGTHEIPYDVTIFVAVKEPKEFIAIDDLQFIDCEQVPSLPLSCPSKKDYQCDVTRKCLSRDRLCDLVSDCVCGGDEAEELCEIVPFEGRFTLQDCDFDSSNCLWYNVRAGHEANSWTHPTGHDEEHKGAFRWRSSRVTSGKSNRLVQMSTPPGFQTTGSIKKSRGSDSHYTGPYVYVTMPPKNAGSVAVLRSVSLQPRFSSGGLCQVRFHYRITALSASLRLDMVAVGKPGRSQVHKVKWEQVVNTNNDVMDPWTWKRVVVDLNTEAINSSYILQFRAITSDPKASGQVAVHSISLSPECFIPDLKLSTCGMSGHIGPTQRRCDGSYGQNGKVNVVRGIQSWVVPETAIYTIQALGSRGGKGFNASDSVLLSRGSRVTAKFWLLKEEELFFVVGQVGEDATCQLTGMLLPAYCFMEGFDPAQNAGGSGGGGGATIVFKRKNGTKPEVLMVAGGGGGLPSHLTNDLKASLARNYFGETTVATVTSAISESSLTEKEAGSILSRPLEGKAPCHDKNNPSAKWESRGGFGAGGGACGGGGRGGPLLGGEEERFTRSTSVGEPGKSYVHKSALYSFMETGIHAGPGFIEISPVRECPCDYHCIWLGARLTNYTCLCPTGMVLQRDGISCAVAQKVMQEEESNLYLGIIAGALFLVFVSIICICLYIQRQSATGRRSGGIKKAVSLVCPCLHLSRRPLSANVLPQRQRPPTVMQVNPNYDLVGTKCPEQGLKDLPRKHLKCICELGKGAFGEVYYGLLSNVPMVDGDLPVAVKTLQPVCTEQTEMDFLMEAVIVSKFNHPNIVRFIGVCFEQHPHYLVLELLEGGDLKSFLRNARPKWDQPSQLTVRDLLRLSLDVARGCQHLEEKHFIHRDLAARNCLLTTKGPNRTAKIADFGMARDIYRNDYYKKAGKAMLPVKWMPPEAFLDGVFTSKTDIWSFGILLWEVFSLGHIPYPGNTNEGVMSLVTQGGRLDPPEGCPSAVFDIMASCWSALPEGRPTFSLIISSLEKTLQDDDMSQRGLPVFYVPPIINSRGLRLHERQPSTPPTATTRAVSNHAHPVSSPNSSGDGYLVPLLRHNYSGKSSDGQVSFSNNGSPRQRGAELDRGGAVGENRANRSHRLLKDIHEPQDDSSDFGDKNRPITKQQFRAPKVFYKPGISPHVTIPDASSEALLPPDRYTDGDALGALPNGAKIKFADDDDVEDDDSDDNDFNTEDGENLKMGVAVALPERSKKKKSYTKFPRPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTL0</accession>
    <name>A0ABM1VTL0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Parathyroid hormone/parathyroid hormone-related peptide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101857406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825752.1">
        <property type="nucleotide sequence ID" value="XM_035969859.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857406"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003287">
        <property type="entry name" value="GPCR_2_calcitonin_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01350">
        <property type="entry name" value="CTRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="4">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035825752.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21189" checksum="DBDD8FE030D06108" modified="2025-10-08" version="1">MDVQEQRARLEKAQVECGQRMLDSLMLGGGGGGGGGGGAPAGAHYNNIFTWSSLVDSDNATVASAATRTDFTLHIANLTKPEPSDGGRRNCGIAWDNLLCWDEAPPGSLQKQACPDYIHGFDTNEFATRYCTENGTWFFHPVLKKHWTNFSACHSTVEMTADMEHADRLNLIRTIGYGVSLCSLVIAVLIMCCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VV65</accession>
    <name>A0ABM1VV65_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826307.1">
        <property type="nucleotide sequence ID" value="XM_035970414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477871"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035826307.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13352" checksum="2D94FA1D735AC4C0" modified="2025-10-08" version="1">MKGKEKGMVHGLDLCYWFDFSVEEMEKFLRQGLDVTIGIGDEDLDLKSRLSAFIADFTKTGSADWPPYNTKDMKYLDFKPRAEVRQGLEMDKRRFWLEELTELVQEKHMHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW40</accession>
    <name>A0ABM1VW40_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein phosphatase with EF-hands 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826632.1">
        <property type="nucleotide sequence ID" value="XM_035970739.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477961"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035826632.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31066" checksum="E9B5E804E31CC10A" modified="2025-10-08" version="1">MDQITKEANPDPEKLNELMFADNLAMMNSKTQLQKHTKQLNVRFEKYDMKIGVSTTEIMTAGHQTNWISASYNDDVLLPPQLLTVFSASGYYEENSNKGAYAKVMRQTNKVKIEQEPGVPEVQLVQYMAPSRGSRRLTFTERISHLERSALQNVKELILANQSCLEAEFAKLDPEETGEISACAWCQVMESVLALDVPWRMLRSRLVSSRARAGQQNVLYHSTFLERRASLRESMVSTWGLAGPVSSLRPSPPGSFLLFSIENTTYSQVILFCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX33</accession>
    <name>A0ABM1VX33_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">26S proteasome regulatory subunit p27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101847513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826975.1">
        <property type="nucleotide sequence ID" value="XM_035971082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847513"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="103"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826975.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22722" checksum="6C211E43B015207C" modified="2025-10-08" version="1">MQSLSLEASLLAVLHTWQIYYSLGRTIQLSQMADDDLKQKGVGLSESLIDAEGYPRSDIDVYSCRHARHQISCLQNDHVALMQEIEDELHVIHSAARATNSVSDVEMPVASGDGMDTERIPFAVIDRVDPGSPGAQGGLEVGDQLIEFGSVMVENFVNLQTVGAVLQHSKNKAVNVLVLRDGRQVKVTVTPSTWSGPGLLGCNIKPMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXW0</accession>
    <name>A0ABM1VXW0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC101864242</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="RefSeq" id="XP_035827253.1">
        <property type="nucleotide sequence ID" value="XM_035971360.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864242"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="18">
        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="19">
        <location>
            <begin position="128"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="20">
        <location>
            <begin position="711"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="17">
        <location>
            <begin position="1085"/>
            <end position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035827253.1"/>
        </source>
    </evidence>
    <sequence length="1551" mass="175815" checksum="F3AD510943351E8B" modified="2025-10-08" version="1">MAPLPQVRVFTLKHGEDSQHKLYRLQKGWVLRFVLGPSLIAAPVRLFSNHPPDPSTPFERHTFYEVKWQSSTGSQADRTDHTAEIRMLLAGSFNFFFTIDKSDKAANRNGGGFFLVDPTLQLGPNKEEVILDEIVCQTVITKLLGPFDEWLGRLQVAAETGYNMIHFTPVQELGISNSAYSIRDQLHLSPVYSPGDKKYTLDDVEKLMEFLNASMGVMSLSDLVYNHTAKDSPWVWKHPECTYNMVNSPHLRPAYIVDRIFEHFSLEVGEGRWQSEGIPKCVNSEEHLSNIHRVLHSKVFSKYRLHEYFCVGVDGILKEFRKAVESNVNGGLLSDETRLSIKQDPQFRRFRSTIDMKVALKLFNTDQVFGDAGPGSFSRTDRINKCCEALTAELVTLNAAKEHEIQGHIDAAISNFVANARWRFITPEGPKIPQVIPDEPLMFGYFVIPKSHEGSVEKEELMSFEDGEHIMAVNGWVMGDDPLRNFAAPGRYVYLRRELMAWGDSVKLNYGESRDDCPYLWDLMAEYTKVSARIFQGLRLDNCHSTPIHVAEYMLEIARKVRPDLYVIAELFTGSEDLDNLFMNRLGINSLIRESLVAWNSNEEGRLVHRFGGQPVGAFVQPRVRPLVPSMAHALFYDQTHDNECPIQKRSAYDIWPTAGLVTISNCAVGSNRGFDQMVPIHINVVTEKRLYTSWLEKEMPERQYINANFGISAGKRSLNRLHYTLAKQGFSQVYVDQVDGDTVSVTRHNPLTHESVVLVARTAFSYPGNPDDQGHIRPITVQGVINEVILEGKVRKSPQFTYKQDPDYINGLPEYYLKLRENFPVHESEMVLTRILQNGETEISFRSLTPGSVIAFRCVLPEQAKGAILDIRRGLGQFGYMMRSYSGNTMFDDTWDTSNFRAIVSRLSLADLNRCLFRIDQEERDDCYGFGAYSIPGAGNMVYCGLRGILSMLASIRPVNDLGHPLCGNLRDGDWLADYTANRLKKHKTLEDLGKWFEAIFANLKLVPRFLVPCYFDAIVTGAYMVLLDTAYELMSDFIKDGSFFVKALSMTSLQVVGYAPQARLAPLSPRLVPRPRTEYNNCRKQDEEAPLSMSAGFPHFGAGYMRNWGRDTFISLRGLLLITDRREEARHIILSYAGTLRHGLIPNLLNEGKGSRFNCRDAVWFWLYVIREYCLSDKNGYSILKDPVSRMYPQDDSLPQEPGAVEQPLHDVMQEALSRHALGVKFRERNAGTQIDEQMTDAGFNNEIGIDWKTGFVFGGNEWNCGTWMDKMGSSAKSGSKGKPATPRDGSAVELVGLCAGVVQWLAEANSSKLYPYDGVEKEVNGQKVKVTYKEWFDKIKTNFERQFYISPKPDKENEPNPELINRRGMYKDSVNATQFWANFQLRCNFPVAMVACPDLFTPENAWAALENAGQILLGPLGMKTLDPADWAYRGDYDNSNDSEDINVAQGWNYHQGPEWVWPVGFFLRAKLYFASKLEKTQPGILEKTKLYAISVLCKHYAEILNNPWQGLPELTNSDGKYCEGSCRTQAWSAATILEVLYDLSKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYA2</accession>
    <name>A0ABM1VYA2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101846375</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827395.1">
        <property type="nucleotide sequence ID" value="XM_035971502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846375"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827395.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="22968" checksum="88727C62F8BCFAE3" modified="2025-10-08" version="1">MGRLFMYAGYLPVDFFPGTRSGGEGGSSKTAPGHTLKPSPLTTMAVAASTMIFIVIVIGVLCLHEALRCMRSRNLSTSQTASEDVEDAKEQEGKAQKEGENYVREGATMSSGYPEVESCRFVASPALAKRLPGHKGQGDKVSLERDDEVGVTTEMSQKEDSEDTNTAQKQGYSDVKLLTQPGKPNDGRSLAGVGEKSTNQMQEPHSDLAGSGCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZJ1</accession>
    <name>A0ABM1VZJ1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spectrin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC101859991</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827834.1">
        <property type="nucleotide sequence ID" value="XM_035971941.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827836.1">
        <property type="nucleotide sequence ID" value="XM_035971943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859991"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21246">
        <property type="entry name" value="CH_SPTB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21248">
        <property type="entry name" value="CH_SPTB_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016343">
        <property type="entry name" value="Spectrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002297">
        <property type="entry name" value="Spectrin_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="46"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="165"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="2229"/>
            <end position="2341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2092"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2142"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2339"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="775"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="987"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1426"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1631"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2164"/>
            <end position="2186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035827834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035827836.1"/>
        </source>
    </evidence>
    <sequence length="2373" mass="275651" checksum="7EA54B6A3897B764" modified="2025-10-08" version="1">MTEIESLVNNVRWDPGVVDEDFDAVNNSSKLFERSRIKALADERELVQKKTFQKWVNSHLIRVNHKIQDLYVDLRDGRMLIKLLEVLSGERLPRPTKGKMRIHCLENVDKALTFLHEQRVHLENMGAHDIVDGSSRLTLGLIWTIILRFQIQDITIEEVDNNETKSAKDALLLWCQMKTAGYPNVNVRNFTSSWRDGLAFNALIHKHRPDLIQYEKLQKSNAMHNLNNAFTTAEDKLGLTSLLDPEDVNVEFPDEKSIITYVVTYYHYFSKMKADSVQGKRIGKVIDNAINTESMINQYESMTSDLLEWIEQTIVILNDRQFANSLTGVQQQLAAFSTYRIVEKPPKFDEKGNLEILLFTIQSKMRANNQRPYLPKEGKLLSDINKAWERLDKAEHERELSLREELIRQEKLEQLAARFGRKAGMREEWLSENQRLVAQDNFGNDLAAVEAATKKHEAIETDINAYEERVSAVVAVASELEQENYHDIDRINARRDNVLRLWNYLLELLQARRMRLELTLSLYKVFKEMLYILDWMEEIKARLLSEDYGKHLMGVEDLLQKHSLLEADVNVVGERVSTVNGQAQRFIDDDFSEIGGYRPCNPEMIQERMNMLDSAYEELRQLAADRRRRLEESRKLWQFYWDMADEEGWIREKEQLMSSPDLGHDLTSVNLLLSKHKAMEDEMTARHSHLQEVQTSSNELIEAGNFGADQIEQRNNEISSQWESLIDLATYRKKRLNEAVDFYQFFADADDVDTWLMDTLRLVSSEDVGKDEASVQSLLKKHKEVTEELKSYQSVIEALHEQAANLGEQDRESPDVQSRLTSIDRRYQELLEFSKLRKQRLIDALSLYKLFNESDGVETWIDEKEKFLTTIIVTDDVEELAIMKHRFDSFEHEMNATASKVAVVNQLARQLMQAEHPNAEEVVERQNQLNATWNNLREMVDHKRDDINVAHGFQNFNIECNETIGWIHEKAKLIESTDELGNDLSGVMTLQRRLSTMERDLAAIQAKLESLQGEAERLEEQKPEEAEAIKEKIAEINNVWMDLKDMLKERDEKLGEAGELQRFLGSLDHFQSWLSRTQMTVASEDIPNSLADAEKLLNQHQQLRDEIDTYAPEYAKIKEFGDKVTEGEEDPQYMFLRQRLQALDDGWHELLQMWENRQQLLSQSLNLQMFLRDAKQAEVLLNQQDNFLSKEDVPIAPLDKQTSVQAAENLIKRHEAFITTMDANDEKINAVLQFANRLMDENHYAGEKIQKKAESINERRDQNRQRADEQLDRLKDQLTLQQFLQECDELRDWLQDKMAAAQDETYRDAKNLHSKYVRHQAFESEIAANKDRLNRVVEEGETIMSSKPETREQIEPMLSELSTQWEDLETTTKEKGERLFDANRSTLYQQSCDDVDGWVTALESQIVTSEDFGKDLTTVNLQVQKQNHLENQMKMKEQQVQELESQSEHLRRLEPDREEEIEARRALVAQRFAKIQGPLMMRRANLEKVKRIHQFMRDVEDEKLWIEEMMPRATSTDYGNSLLSVQLLIKKNHSLQVEIDNHEPRIKSVVQVGQELIDAGHSQSEEFRALIEDLLQRWQELKDAIDARNQRLKLSEIAQQYYFDAAEAEAWMSEQELYMMGEERAKDEIGAQNMMKKHQTLENNVEDYAEVVRQLGERSRELMEEEHPESDQIAVRQSQVDKFYAGLKDLAQERRGKLEEVFKLYTLHREIDDLLEWIADKSAVAGSNEPGQDYEHVSMLKERFKEFARDTENIGHERVASANEICDDLIASEHSDAASIAEWKDNVNDAWADLLELIDTRTELLQTSWELHKFFYDCKDTLERIVEKQNYIPEELGRDAQSVAALQRKHANFEHDLVTLGTQVEAIQTESLRLQAGYAGENAQTIVDREAEVLEAWKNLHVLVERRRLTLADASDYYRFMLMARDLLLWIDDITRQMNTQEKPRDVSGVELLMNNHQSMKAEIDAREENFAICINLGRDLLNRQHYKQEQVREKLIQLTLLRLDMTDLWNERWEHLQLILEVYQFARDAAVAEAWLIAQEPYLSNQDLGDTLDAVENLLKKHEAFEKSAATQEERFAALLKPTTFEIRDREKKKAEEYGKSHPDEIEKQKEERRRQYIQEFLPPEPPKPEPVVEVEQPVAAAAPDNQVAPETVEEAVGQPISSEEKSETDAGVRRPRRERQSREAEEVDEPDSFHRRSHARNDYPQPSSESPSPRKPRGGKAAAPSESVSLEGMLSRKHELDVGERKAGNRSWDKLFLVLQGPSLSCYKDQKHAKTDPNNRIHHEAAIDISGASCEVAADYTKRPFVFQLRLTNGGKYLFQAKDEGERDMWINRINQAAGPSAGAMPTKSQTLPARIEKEEPKKRGLFSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0P9</accession>
    <name>A0ABM1W0P9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477128</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828242.1">
        <property type="nucleotide sequence ID" value="XM_035972349.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477128"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038875">
        <property type="entry name" value="PLA2_conodipine-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687:SF1">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035828242.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13385" checksum="56F6ED1A5493B2EC" modified="2025-10-08" version="1">MGDIEDIGEQREVSSLFLKNADQCPAVREYSTNCELADLYSLPVDYEARALCNLHEMCYACGQSLSIPQEHCDRVYRVAASALCRDQKTCVVESEIFLRTMKLKTRYVPHAQPSCRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W100</accession>
    <name>A0ABM1W100_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein F23F12.3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828343.1">
        <property type="nucleotide sequence ID" value="XM_035972450.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850057"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828343.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26440" checksum="D97206A33AD87B16" modified="2025-10-08" version="1">MTPDWQCIVSGSEVNTSDWDTGPNSTTFKKCQVGGVKCQRYHFYGSSHTLVNEWNVLCDRAWIKQVVTSAQFAGVMVGSFVGGWMGDALGRKNSLYAFMALHALTNIVCAFSVCWEMFAALRCLIGVGCGGIMVITFPYMLEFLPRHNRAFLALLPFWALNLAIFAIAALILDHWAHVHLACGLISTPVLIGWFAVVSAVYYGISFGLNSLEGNIFLNLFLLGLIDVPFYIPAYFLTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W167</accession>
    <name>A0ABM1W167_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette sub-family A member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101861159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828410.1">
        <property type="nucleotide sequence ID" value="XM_035972517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861159"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="71"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035828410.1"/>
        </source>
    </evidence>
    <sequence length="950" mass="106443" checksum="24066379B598CBCD" modified="2025-10-08" version="1">MMIVDIGLHLLITWYMDNIYPGEFGVPKPLYFPFLKSFWCPSHIKEEVSTQSEQVDTKHLETDPQNLNAGIAIKDLTKIFAGGKVAVAGMSLNMYEDQITVLLGHNGAGKTTTMSMLTGFMAPSSGTAVVNGYDIRSNIDEVRETLGLCPQHNILFDQLTVREHLYFFAKMKGVSGNLDALIATVVNDMFLTGKENTQAQHLSGGQKRKLSVGIALIGGSKVNRVFLLVVILDEPSSGMDPGARRHLWDVLQRNKRGRTVLLTTHYMDEADALGDRIAIMAEGVVKCCGTSMFLKKLYGAGYHLIIVKDDECRVDEITQIVRSTLLMPLALTAGGVAILNSGSSEKQEVGDQGTVRYDLSPFYRPIVSYTDGSPASSISSDLAEKYAEIFSTHPGTAEKINQDKSSNVSEYLLWKMHDVGFDIFSQRFPIGAEFLPQSNNSIKGVALYNDRAWHAKPVALVQMLNAFIREYVGDDYSIQASLHPMPKPMLARGSSFRDTGDNLKNIYPLTIFLSLGMAYLLSSFAYTLIVERQRGCKHLQEVSGVNPFIYWLATFLWDYIIYLAVVIGIIVIFFGFGETALIGEDAFGPLIFMFLLFGFAACFSSYVFQFVFKSPPTGFVVTLILYFILSLFTNLMLTAIKSKWRNDFRNLFSVLFLPFNLNKFITDYYNWHSEVPSKLAFAASKKPGQSVWDFDSPGVGLYVFMMALHAGVALLLLMLIEFHVLQKIWYLIRKSGERKDQAPLQEINMTSLFTEDSDVAQERDRIFRTTLPQLFTTDSLILMELSKNFGQMTAVDHLCVGVPEQECFGLLGQNGAGKTTTFKMLTGQEMVSWGNAYVKTHDIKDNIKKVQSNMGYCPQFDALTDQLTGKETLTLYCRIKGIPEEEITRVCNSLIDSLMLTPHADKLVGKYRYLSRVPRFRPVPETHTRAAEEMLLLLLSDYAVETQLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1F2</accession>
    <name>A0ABM1W1F2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein LOC101862454</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101862454</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828495.1">
        <property type="nucleotide sequence ID" value="XM_035972602.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862454"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045428870" evidence="15">
        <location>
            <begin position="24"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1162"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1238"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1282"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1332"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1418"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1451"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="16">
        <location>
            <begin position="488"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="1174"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="757"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="855"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035828495.1"/>
        </source>
    </evidence>
    <sequence length="1570" mass="174555" checksum="03A9CCCBED9BA0E2" modified="2025-10-08" version="1">MPLHHTGQLSVGMFCVVSLLCSATCLRRTAESDAVSSRTEQARHSGSDGRLPGTDGWGVGLTSGQRDENSRRSVTSEHRLTQLDEHPSVKSEHRPTQLDHLSRFRSRDGLGRVKRQSPENGNLDENCDNPADNSTHFQFEKTFRAHCKCNFFAKVYEITSVPGDVKIPEDIKCGSEAGLQFREENGVFHFRSPCCSNFCESIFHIKAPRGRGSGYILEFLELNVPSPLIINSDGSYTCKDSRVLFRNPDYEICGTVVPKPFKVWSDSAFFVVQTDSNRLCRDAISFTLEYRKWDVMDQMANICQLQLQHTVVSEGQSGFIMSPGYGEVHSYSEFDFDLCGWDMEVSNNSILQISFVSHGAGYIDYNSSYITVSTKGQPHLDHHHAVDVRFNQEDYSVIDGYRLTLPSHRARVSFSSYVASKRFKMWYKAVNRDSFIPIIDKFVLNCSGYEPSLPAHIRCDLHNDCVGGEDEVNCTYKDGAWCPGGFVLGSSCYHLHDPQPDGTWQMAEDLCEQQYNGHLVTPNSEEELTFLSRLMIQMYDVKTTWYLGFRRRGAGSELLYRKVYQGLDGTTVFGGFKKQFVFDVAAACAVWDITALGYQKEVTNIPCHQVWTKFQFHQDYLFYYLIQPNVSIACESKKPAVVQPLVTSSSAAVWTDKRKTFECVVSKERVSLSRRCDWLSDCWDGSDEVDCAGLSDAPSYVRFTCTSGRPLWYSHVCDGVSDCVDGSDEEFCAPAPDDNPALAVCADGVPVPASAWCDAQPDCLDASDELDCSRCNGGALLCPSVGCLPPHWAHDDALDCQLTDKSGQWILEPDFVPHTVDAQPPPGVVRPDGYGKVTIEPLDEGEPCPPTHVQCPKGYCIPMYMLCNGHTDCPEGEDELAETCQSFCKGRYKCHQTSVCLHDDHVCDGWFHCPLHDDETFCWTNDTCPPGCVCSGEEITCRSGFVVGELLRVRRLDISHTAQPNDSLTVQNHYIIALFAHNSNIRQLGLLSMVNLYHLNLSDNALRNLAPDAFERTPGIRHFSLARNKLTEMDLQPITSLKNLEILDVSGNSQVRIRSFSFTGLARLRSLQLDDMGLTVVETGAFDGLLELRTLTMRGNSISVFQQGMLLALSQLTSLSGDNYKLCCPIMKPKSLSTGTCQAPKDEISSCEDILRTPFFRVFLWLMASLTILGNSCVLVYRLCVERKPSTLSYNTFAINLCASDLLMGIYLAIIGAADQVYKGRYLWEADSWQSSSYCSLAGFLCTVSSEVSALTICMVTLDRYLALSFPLANVHLTRKKARCLVLVTWVVGVLFAGVPLLPPLSHWRFYAQTAVCVPLPITRADFPGRDYAFSVFILVNLALFVAIAVGQVLIYRSVKANSFQMTVAVTSKRLVLFYPCRCRCCCCCSSIGDTIPLAAKAASSGETNQDATIAKKLALVVITDFFCWFPIGVMGLLSKVGVPIPGEVNVVATIFILPLNSALNPYLYTLPAIRKTLERWEARSRRNKAGSAGFRLRSINLPHTDVSSGSTQFESVCSDSSMSAGGAADVIKAQACLDKLRAWLEKRRISREKVKQILSHFQTNTSVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2Q7</accession>
    <name>A0ABM1W2Q7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101859824</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101859824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828950.1">
        <property type="nucleotide sequence ID" value="XM_035973057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859824"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035828950.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="8880" checksum="420A187E4451384C" modified="2025-10-08" version="1">KAKEQQAAGQSTRVTLAAIRQTAQAVDTIVTYTLSLVSDLITITDPENGDKRRALQKRGWSVGVDVGYGSHSGGRVGVSVGFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2W5</accession>
    <name>A0ABM1W2W5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829008.1">
        <property type="nucleotide sequence ID" value="XM_035973115.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860457"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF59">
        <property type="entry name" value="CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829008.1"/>
        </source>
    </evidence>
    <sequence length="952" mass="103793" checksum="358E56FFFFCDDE47" modified="2025-10-08" version="1">GKEELLVEFPSPTLAQPRPDEVEKRDRRREQNRRAAQKFRKKKKERGEHLYEESQRLEYHNSTLRSEIKQLHEERDQLTRIIRSHASICPLTPRQSPLTVPRESPLPQQIIRESPIPLAPPRVGLVSPSPTLVAPPPPSLVSPSPTLAPGPPTLVSPSPILVQSPALLVPPTRESPVPLLIINPSPRESPCHMISPRLPRKSPVALLRPNPSLAPLADKSSEKSSSSAPSGSPPKQSKSSASPRLSGPKPVIPILPKPASSPKTIRSFITSPLPRPITSPLPKPIISPSPRPIISPLPRPIISPLPRPIISPLPRPLTSPKTPKGGAITSPLPIAQSPVSVGGRAIHQSPVFFSDSCFSPSTRPLPTNPSPVSFTDRVSGRRSVHQSPVFFSEKPPNGLASTVNSANSSLGGSVSKFRHTSSTSSSGSSSSLASLLRQESPLSVLSNSSVGSCSSVFLSNSGNFNSNNNNSNNNNNNSGSISSNSISNNMCVDVCNPNNNNSGAMNTNNDDVIEDALISEDLVHQCADALSTSANNFTSSEFRETNSVTPVNVWGSSNMVPSNNDLGCAQTHNTTESTIVKNFLTMSNNNNTNNNNNNHNHNNFNNNNNNVNNNNNNNNIISSNNKAGNCEDALSSFGLVTPRQIQGLGQGHLSNQLSGQFHNISAQGQTSAENQQRDLLGGQSHFQAPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEQLMNGLGGNPEQTYQQTHPQMQQQQHQQHQQHQQTLHQLQQQTHQQTHQQTPQQTHQLTHQPTHQPTHQQTHQPTHQQKHQPTHQQTHLQTHQQTGQSGLHPSFSRPLPPCLDAEDNTLSLEEIERSAEICENSADLLDLIDIQTLLELSAEHNNGGSLSPQGNGGAVSSSISRAEAISCCNNDSMSNIDATDDLLAFHSPMDLLPTPPAQQMCGVGLDSMVHRYSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W307</accession>
    <name>A0ABM1W307_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein C4orf45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101862312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829050.1">
        <property type="nucleotide sequence ID" value="XM_035973157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862312"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027814">
        <property type="entry name" value="DUF4562"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34833">
        <property type="entry name" value="GENE, 17359-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34833:SF1">
        <property type="entry name" value="GENE, 17359-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15123">
        <property type="entry name" value="DUF4562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035829050.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15545" checksum="29B46E3A0ECB0508" modified="2025-10-08" version="1">MPWDYQEESPQYNYVDNVFPYAYPSSGNVTFTGPDGLRDYRPHMITDPHQVGVGDQSTEHSGDVAYVFRPAPGTPMPRPRSCIPGEIGWGIPTLTDWATPNTGQQIMGTHGISDKNCMGCVGAILGHPINEIADSIQRLQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-09-13" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q45R39</accession>
    <name>Q45R39_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 9">Ezrin/radixin/moesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100533392</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2005-07" db="EMBL/GenBank/DDBJ databases">
            <title>Role of ERM in neuronal growth cones.</title>
            <authorList>
                <person name="Medeiros N.A."/>
                <person name="Forscher P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="7">Central nervous system</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DQ119138">
        <property type="protein sequence ID" value="AAZ40190.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191607.1">
        <property type="nucleotide sequence ID" value="NM_001204678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q45R39"/>
    <dbReference type="GeneID" id="100533392"/>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17187">
        <property type="entry name" value="FERM_F1_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000003">
        <property type="entry name" value="Radixin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000002">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000013">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002305">
        <property type="entry name" value="ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="6"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAZ40190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="NP_001191607.1"/>
        </source>
    </evidence>
    <sequence length="586" mass="69178" checksum="7EE8B91E3BED287C" modified="2005-09-13" version="1">MPRPHINVRVTTMDAELEFAIQPSTTGKQLFDQVVKTIGLREIWFFGLQYVDSKGYSTWLKLNKKVMGQDVKKEVPLQFKFRAKFFPEDVSEELIQDITQKMFFLQVKEAILSDEIYCPPETAVLLASYACQAKYGDLTNDNPKPGALANDRLLPQRVYDQHKLSKDQWEDRIKSWYGEHKGMLREDAMIEFLKIAQDLEMYGVNYFEIKNKKGTDLLLGVDALGLNVYEKDDKLTPRIGFPWSEIRNISFNDKKFIIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREDKLAKQQERAQLARMRQEREESDRLRKDLEEKVRIMEEEQKQRMKELEELQGMIRDRDEKVAELTRLREELDSERKRAEELQRDIERSHEMEQSERERLAAELSATQASLQERLTEIESKEDVVSSLHEELESAKRSAEEKENELSRVMISSQQREQELEAQLLVRSEINDHHDEGEENEGDDKKEFDADLTVHEDAHLMPRPEEDRETQQSKDKRLQEQLRALKEDLDLEKTKSTAVDLLHQENQRQGRDKYKTLKQIRQGNTKQRIDEFEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-12-07" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5UKX5</accession>
    <name>Q5UKX5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC100533445</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2006" name="Cell" volume="127" first="1453" last="1467">
            <title>Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Edwards J.R."/>
                <person name="Puthanveettil S.V."/>
                <person name="Kohn A.B."/>
                <person name="Ha T."/>
                <person name="Heyland A."/>
                <person name="Knudsen B."/>
                <person name="Sahni A."/>
                <person name="Yu F."/>
                <person name="Liu L."/>
                <person name="Jezzini S."/>
                <person name="Lovell P."/>
                <person name="Iannucculli W."/>
                <person name="Chen M."/>
                <person name="Nguyen T."/>
                <person name="Sheng H."/>
                <person name="Shaw R."/>
                <person name="Kalachikov S."/>
                <person name="Panchin Y.V."/>
                <person name="Farmerie W."/>
                <person name="Russo J.J."/>
                <person name="Ju J."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="17190607"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.09.052"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AY706155">
        <property type="protein sequence ID" value="AAU05111.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191651.1">
        <property type="nucleotide sequence ID" value="NM_001204722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5UKX5"/>
    <dbReference type="GeneID" id="100533445"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAU05111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="NP_001191651.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29909" checksum="00B90B94740E0F48" modified="2004-12-07" version="1">MPQNEYIELHTKRHGRRLDYEEKKRKKEGRRPHEMAVKAKKLRGIKAKLYNKKRHAEKVQMKKTIKMHEEKKTKQKSADNDSQFGNPSYLLERENQIRAKVLSNTIKQKRKEKAGKWNVPIPKVKGVSEAEVFKVVKTGKTKRKGWKRMVTKVTYVGEGFTRKPVKFERFIRPMGLRFKKANVTHPELKASFFLPIIGVKKNPSSTMYTSLGVITKGTVIEVNISELGLVTHSGKVVWGKYAQVTNNPENDGCINAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q6Q0B2</accession>
    <name>Q6Q0B2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">ATP synthase F0 subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">ATP8</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="1 3"/>
    <reference evidence="3" key="1">
        <citation type="submission" date="2004-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="NCBI Genome Project"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1 2 3" key="2">
        <citation type="journal article" date="2006" name="Mol. Phylogenet. Evol." volume="38" first="459" last="469">
            <title>Complete DNA sequence of the mitochondrial genome of the sea-slug, Aplysia californica: conservation of the gene order in Euthyneura.</title>
            <authorList>
                <person name="Knudsen B."/>
                <person name="Kohn A.B."/>
                <person name="Nahir B."/>
                <person name="McFadden C.S."/>
                <person name="Moroz L.L."/>
            </authorList>
            <dbReference type="PubMed" id="16230032"/>
            <dbReference type="DOI" id="10.1016/j.ympev.2005.08.017"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="AY569552">
        <property type="protein sequence ID" value="AAS67864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_003694.1">
        <property type="nucleotide sequence ID" value="NC_005827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6Q0B2"/>
    <dbReference type="GeneID" id="2768709"/>
    <dbReference type="CTD" id="4509"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS67864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="YP_003694.1"/>
        </source>
    </evidence>
    <sequence length="50" mass="5634" checksum="4C016BB98A5C761A" modified="2004-07-05" version="1">MPQLSPMMGIMFFAVILAFLLVLVISMKTSMPLLSSKEGQKSPNQKVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JB71</accession>
    <name>A0ABM0JB71_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial genome maintenance exonuclease 1</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MGME1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005089645.1">
        <property type="nucleotide sequence ID" value="XM_005089588.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845893"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03030">
        <property type="entry name" value="MGME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340:SF3">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005089645.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60384" checksum="6E6815ECB9652F90" modified="2025-10-08" version="1">MAFRRLLRLHPPLQLHGGHQQPSLSVLSSRFLSKKYTYNLNELIAWKKQTQQLFGSTRKPTKTGKLKKLKSVNPSVKENLETLSAVSEQNKNSSLGQNSVSAGETITNRKQKVKQSADIIEDIPDDHFVSQVFPSDAVVLKESFRDIERIPDNIILDNGDLLKDQSLPEVRSSSFSPRTARKKTERKNKASSKNYEPSEVETTNASLHSVKKQEISTKQSQEEFTEDGIFIPKIPPIPQGDQNSYSSTIGKNKQAASSSLPGSGSFVNKSTTSSEPVEPPSSFDIISKFPLVPNDETKWDSKSKEFKHDVERMSLRVLPSVKSILNKTMPDMNRFFLNRWREKMINELGEEGFKKHQEATIKKGVNLHANVMEFLSGKPHSELQIMPDNEGHWASLQTALGALGDIKYIEAEILHPNLLYRGVFDCLAQYRDMLCVIDWKTSKQPRPLLKNTYDDPLQIAAYIGAVNADPKYTSQCGQANHGVIVVAYPDGSPAHVHMMDRKLCEQYWHDWTGRLYNYYQLSYTQKIGNISASGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCF9</accession>
    <name>A0ABM0JCF9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101857298</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090508.1">
        <property type="nucleotide sequence ID" value="XM_005090451.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857298"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.590">
        <property type="entry name" value="CpcT/CpeT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010404">
        <property type="entry name" value="CpcT/CpeT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038672">
        <property type="entry name" value="CpcT/CpeT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06206">
        <property type="entry name" value="CpeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005090508.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="69985" checksum="4AA1420F623D1D17" modified="2025-10-08" version="1">MSTIRAKSSSFAPLTTRSLLPDKLSTLLIKFLLVCCLCFLDLCQADKKSLLRDIDVLASELPGTYSNVRQYRQHAQGPTPPGRRPILLRSELYRISSPLFNDSLTLYFQDFTRFQTTPFRSGFYSFVADTKSNSIRMKTYRLRKGVFLPRQGVLGRNASKANQQHLDSWQDTDVISSDLFKVYDIDTQSPRTHSACDMFWKRIARYSFAGVTGPVCLASLGRDKIRIGVSMTLAKNKLMLTEGWYKVKDGTRITEVKVPYILKKIPKSKSSHPQAAGRLPGNKKKSKKEILSNETTKKEKKKDKTKNKKKGKSGRKGNNKRNRTKYAGRRRLRARSRSHHRLRMPPSDPVMVDNFIQVVHALKSGRELSFLVNLSACSPQPREADSRTLFGGKVKDFVYVSQDGNDYSRKSSYVFFTTETSVVGNNGVETIRREYTLYLRRRVFIRVVKFRDEEQPRSQVLYMCKLYRARNGKGAVKMFYDPDIQVVKATSLAAMTSALDEGRALRVITDLGHCAGQMTGSPLTVGGIISDFNMVNGGRALELLLPIANKFEGSDNPRGLSGSISITGEVPFVRVGGPRPSMGKQLYVNSAYTCTLSSSNVVYPEDEKLKQAPGVRVYYHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE52</accession>
    <name>A0ABM0JE52_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Leucine-rich repeat and fibronectin type-III domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091619.1">
        <property type="nucleotide sequence ID" value="XM_005091562.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846190"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="272"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005091619.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58939" checksum="1515756182168E4D" modified="2025-10-08" version="1">MRCGVGVCVWGKGVGVVLLVVIFSSQVHTTFTCPKDCFCAPHSKNVQCANKEFQKIPDGIPTETLELNLNENKFKNTALTRRNFTELYNLERLYMIDCGIETIAVETFADLVQLSWLDLSKNNIRFIADYTFRGLHLKHLFLNDNNGIQLSIGAFAGMTTQGLYMHNCGLRRLPVDLMTPLNGSLKTLWLDGNNFEAFSDKWLYFFQNLAHIRLGGNSFHCNCEIHWFYAFFKKSRTSLFAGREQPQCASPRIVKGKNFDELTDEDFRCELPTFKNVDAVFDSKMGKLTCQASGDPAPTLYWIRPDGTTETYYPRGDHEGQENMGVMFMTDLKLDSKDAYKCVASNPAGNVTFSLNVVWPDIRPPPPPTPKPTKPPTRVNNDNVIRADSSSTPTNKIFKPYARDDSGVYDLSNVNSKSSKMANSDKPHEPLATDGDNHFSIVDIVGAVVGTFLLTLLISVTLFHFYYRRRERERMRQDDHYSVPDEVNNKRGPNSVFIMNEAEENRIKMINHHNNAECPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFP9</accession>
    <name>A0ABM0JFP9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854778</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092611.1">
        <property type="nucleotide sequence ID" value="XM_005092554.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854778"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092611.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="53931" checksum="7F6BCFA6C9D6F417" modified="2025-10-08" version="1">MEPPRTRSMTQPAPPPSLNSLPTELLELIFCNTDGVSFIRLRSMCKRFKAIIDNIENSSNPSIWIKLLEKEFVPECLETVACTKYWRQILPFALKTMFVQLKESVGLVQCRSWFTLYVLRNMHVHLTEDICFVDGAMKIADQLKGHKILRIKGFPAESWPPMVYFTSNNINGEAVNKLCYAASLRTTEVGHISTGASVAGRVLGSQYFCHIENEVVNITLDAHVQCSWNHFKAFFGRSFKGQDKLLLWDSWEQDKSVYSRAIDFPDSTVVNMAMSENWLVAVNSSYRLVFATAITNFKENYNPDNEPLDVVLPKIYACYQLRSCVQKMVLRGSLLIILTDDGLIRITDISKNKEGKPVFSDFHQLVLKGSSLQPTRANTSFYHNRVRDFTFYGPLFAAVSEGGLVYVSFLEKCTVQSFQEHASQSMLIDAPTMGTTTKVTMDYCGGLTLALLERYIDNLQWSSAVHVIYVHKAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFW7</accession>
    <name>A0ABM0JFW7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neuralized-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092761.1">
        <property type="nucleotide sequence ID" value="XM_005092704.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849593"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03717">
        <property type="entry name" value="SOCS_SOCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF8">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="1">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005092761.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="32790" checksum="2D05916A7070083A" modified="2025-10-08" version="1">MPVKRFHKSHGQNIRLFQGSTVALREVSFAHALVFSEKPLQPGEIFLVEIEKTERGWSGHMRIGLTEVDPAKQTNGLPQYALPDLAQLGRCWVSAVTKSRNRLQYYSPDRARSSLQSSYSSVLGTGEVINTACGRVRRSMLQPSYSLFRSSFASNHANGQSASSTPSSSSSSTAFEGEEPSLKAAKKLILATDVGSRIGVMYCPDETGYFARMHFIINGEDQGPSDELIPLTCDSPPLYAVVDVYGTTKQIRLIELYKVSSLQNACRDLILQTTPQHLLSALPLPQKVIQFLCEGDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGV8</accession>
    <name>A0ABM0JGV8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein SGT1 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101856874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093395.1">
        <property type="nucleotide sequence ID" value="XM_005093338.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856874"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="146"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="3">
        <location>
            <begin position="259"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005093395.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39038" checksum="76B7051F064151E7" modified="2025-10-08" version="1">MATAAELCRQANEQYVDEDYQRAVELYTEAIALDGGRDDIYCHRAQARIQLGKYSEAAADCDQAMKLNENNSKAYIKKGTALFQMDEIGKALDVFKEGQKRFESDSVYVGWIKKCEDKLPSPKAETESPKIPQPAPAEKAACASSPSAVRHEWYQTHTHVVVTVLAKNVKKDNLSVDVEDRKLNVLIKEYQGSPVDLNFFLAHTVVPQESQTKLFASKVEIKLKKSEGIQWPKLEGSAEEKESVTPLAAAPIPEGDVPKYPSSSHYTRDWDKLAAEVTKEEKDEKLDGDAGLNQFFQKLYADASDDTKKAMMKSFSESGGTVLSTNWSEVGSKPVEVKPPDGLEYKKWEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIA4</accession>
    <name>A0ABM0JIA4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="10">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101855475</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005094272.1">
        <property type="nucleotide sequence ID" value="XM_005094215.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855475"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF93">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="13">
        <location>
            <begin position="419"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="13">
        <location>
            <begin position="519"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005094272.1"/>
        </source>
    </evidence>
    <sequence length="615" mass="70428" checksum="F9924824EB5651A2" modified="2025-10-08" version="1">MATSSSKGDVRPKDVIPEVLNDPGTGKRYLRGRFLGKGGFAKCYELTDMDTKAVWAGKIVPKSLLVKQHQKDKMAQEIAIHRSVEHKHIVKFHSFFEDNDNVYILLELCRRRSLMELHKRRKAVTEPEARYFVRQIIEACQYLHGKRVIHRDLKLGNLFLNDEMEIKIGDFGLATKLDYEGERKKTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCIVYTLLVGKPPFETSCLKDTYMRIKKNEYHIPHKITVPASNLINRLLKANPTERPNMDQIMEDPFFTSGCLPPRLPTSCLTMVPRLDALMKVPAVDPIMSGSGGALTADSAARKPLLDVNEAQMRPYTAEPGKKDLERKPFREMDEPNGDARPDTGRRSDDEPRDYYLTDLCGQLSAVVTAKPGERPNPMLDECEDPAAIPIYWISKWVDYSDKYGLGYQLCDNSFGVLFNDSTRVILLTNGENIHYIERDGKEHYHTIRQFPETLGKKVTLLKYFRNYMNEHLLKAGANMTPRDSDEMIRLPFLRTWFRTRNAIVLHLSNGTLQINFFQDHTKIILCPLMAAVTYIDEKREFRTYRLNLIEKYGCSRDLASRLRYARTMVERLMNSKSASSNRAKSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIE5</accession>
    <name>A0ABM0JIE5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NAD-capped RNA hydrolase NUDT12</fullName>
            <ecNumber evidence="6">3.6.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">NADH pyrophosphatase NUDT12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Nucleoside diphosphate-linked moiety X motif 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC101851180</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress. Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>NAD(+) + H2O = beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11800"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:11801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90832"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:48869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NADPH + H2O = reduced beta-nicotinamide D-ribonucleotide + adenosine 2',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:90832"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:60821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Homodimerization is essential for its catalytic activity and protein stability. Interacts (via ANK repeats) with BLMH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005094349.1">
        <property type="nucleotide sequence ID" value="XM_005094292.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851180"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="22">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="23">
        <location>
            <begin position="350"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_005094349.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="56027" checksum="A058B56C0978AF0D" modified="2025-10-08" version="1">MTLFSRTLRCQAAFRRFPVELSSPGAPGTFNNIRKLSQTFSRTSCRAPVEAVAVRGKMNNNNYPLDYSRGGIKEFNQRFLDSAARGDLAEISGLLGAVDINVKSERGWTALMFAARNGQTHVISILIERGCDVNCLNASGQTALEIARFWNHSEAASVLSQHKQGVEFDQIHNYFSLNPLYRASEMRKDTAGLQAAKNNMSTKFVLFSDQKPFLLRSEEPSRKYKFAVFNINQLGTELLERGTVIFLGLETWDPDSNAWFAVDIKEELSDIGPKFFPEGKYATPFPVTMQMEPTQAGIFAEAHSVLCWLDKYKFCSTCGSATKIAEGGYKRVCQNWECSSNKGVQNTCYPRVDPSLIMLVVSPDKKDCLLGRQKRFPPKMYSCLAGFMEPGECLEDTCRREVEEESGIKVGRVDYHSSQPWPFPAVLMLGCIAYARTSALKCSKPYPQVDTSELEEARWFSRAEVAQMLAGQHPHGLYVPPGEAIAHQLIKSWVASSFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ70</accession>
    <name>A0ABM0JJ70_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101848424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005094866.1">
        <property type="nucleotide sequence ID" value="XM_005094809.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848424"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="678"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="824"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="852"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094866.1"/>
        </source>
    </evidence>
    <sequence length="1067" mass="120937" checksum="87D90EFB9E0A4F7E" modified="2025-10-08" version="1">MEFAIQRPEKSSQDLPDSSRWTILKARFQLFCQNVPAIDRSHFTPHATTASIFRYLLRGSELLLERINSHLSSSKIRIEPQELENILTEIEHFCVPGFLLLYERHKFFTRCQGNDESVHSFIVDLLSLADNCCFEEHKKRYLSSRIVKGVRDEKLRQKLQSVDKVNLQQIIATCLNFASEDFGRCQGAKFGLQVKLSFNENCDSDSENVDTSSCNPLVNNNAAVRGNGDNLTHVHAESCDRNERSERKAVTSGSGLVTQPGRPKRNVKKVVRYGVSDVDVAEQKVSKDESSSETVICRVFKKDAVQGQSETGPKLNDVSSTFDGIDSPKQESVEMKRQEEYQESLLGTMYLSEDDVDLSSGVPENNVSSHSVGVNERQACLEVNKLESCISSASHPEDGGDSITCGPNLPLRRDLQKNAKHKCSECSSSYATRNLLKRHVQRTHSRKKVNKCDICGVNFLSSSHRTKHMRQEHPESLTFKCANCPMTFDSQRALDQHKVSHSKEEKVKCEDCDLTFRSMQEYNQHRRKEHRTSRYPCNICGVQFQYPSKLKLHAMSKHNATKPFMCEICGASFAEKSILINHKNIHTGEKRHECATCGRRFLLKTTLNNHVQTHLDHKPHTCNVCGVSFKLSYYLRNHMKIHSQNRERPHVCATCGAAFLKSYQLRNHERKHTGEKPYKCTICDMAFSQMSSMKKHVKRIHEGVKPADRFSCEFCGLSFTHSCKLKLHLMKHTGERPFVCSLCGASYRENHQLSKHMKIHSGQEPFKCPICGQKFLQRSHMEGHVRKHTGERPFSCPICSARFSLKGYLRDHMKTHDSNRERRYKCGVCGKAFTCSSHMRSHERLHSGEKPHRCHICNTRFTKRSSVLKHLKRTHGIHNPPALTTDHNQQLQILQPHQQQQQQHHQTLQPLQQTPVLNHSAPENLLDVIGNSSNSSFSITCGNTRVPLSSASVLQAPPLLFQLSGKPTAGSTGTLGLDTGANFHHHAELQPLTPLTSDPHRIQLQPTLSQPLEQLQQHLQQVPTAGSDLLHLQQLGQSADLHRQVVHSEMNSPNLHPQTHATYTLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJL9</accession>
    <name>A0ABM0JJL9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101862104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095183.1">
        <property type="nucleotide sequence ID" value="XM_005095126.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862104"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016820">
        <property type="entry name" value="Mediator_Med6_met/pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023869">
        <property type="entry name" value="Mediator_MED6_meta/pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR023869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005095183.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28274" checksum="E288EAE681CA35E3" modified="2025-10-08" version="1">MDHKSDNILGISWHDTAWVPHLNQSNILDYFSERTNPFYDRTCNNETIKMQRLNPDQMLNMTGLEYSLLHAQEPILYVIRKQHRHSPTQATPLADYYIIAGTVYQGPDLCSVVNSRMLNTLHNLQSAFDEAQSFARFHPSRGYSWEFKEKEEKEPTAKDKKKKKKEEASSSFQRERVDLLLGELAKKHPPFFISPTQPAVKEEAKPAAAATAEVKTEKPEEKPATTTPAAAPANGSMRPPPEKKQKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLK4</accession>
    <name>A0ABM0JLK4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heme-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096555.2">
        <property type="nucleotide sequence ID" value="XM_005096498.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864217"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046021439" evidence="2">
        <location>
            <begin position="24"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096555.2"/>
        </source>
    </evidence>
    <sequence length="203" mass="23320" checksum="9A7BD79645B77131" modified="2025-10-08" version="1">MTSYLSSTLAVLACLCVTTFAQSKPSFCKTYECPLFNVDTSNGYEMRTYTSENVWVGTTITSRGSYMGWMEQSRMFNRLFRYISGDNEAGTRIDMTVPVLMKFEDLQNGQFRKTMLFYLAIPNPPNPSNGDVFLETVPANTNFMVRSWRTFFWATTRSYNDNMDALRDAIGSSASVKPNLFYRVSYDSPMTFGRHNEVWLEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLQ7</accession>
    <name>A0ABM0JLQ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sex muscle abnormal protein 5 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096636.1">
        <property type="nucleotide sequence ID" value="XM_005096579.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862867"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="159"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005096636.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25275" checksum="C60E69869E39A2D9" modified="2025-10-08" version="1">MEAVALWDFTANQPDEMSFRRGDRLCVVNMEEDGWYKAVLGPNSGFIPAAYIKMEPNEWFQNPMTRADAEAMLLKKNCVGSFIHEDGNFVVRKAETDSNGFSLSVKHEESVQHFKILRDANNKFYIWTTSSFSINQLVERYRTENVSGDPRRIMHLKDMKREFFKAMYDFAPANQEELELKKGDLIRLIAKSDENWWEGEIDGRCGFFPKTYVKEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMN8</accession>
    <name>A0ABM0JMN8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptor daf-37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101856340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005097278.2">
        <property type="nucleotide sequence ID" value="XM_005097221.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856340"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="84"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005097278.2"/>
        </source>
    </evidence>
    <sequence length="399" mass="44052" checksum="483A8E0FA3F48006" modified="2025-10-08" version="1">MASNAVETTAAAMGNVDLTYASSSAIDTLTSTIATVLSSSLAGVDEISKNMNKEMEAPMKIDQYLHYLMSAIVGPIVCILGLIGNVLSLITWCRPGMRSSTGRYLTGQAVADFGVLLFFLLCDSVQFWAPSVGNSEVYGVFFCYIGYPFFFLTIICSIWFTVGVTVDRYIMVCWLTKAKRLCNERHANFGLLLITVNCFLINIPHFASFSPVLDRAENDTGKTFVHTDFEKGSGGQFYEFWIHCIILILIPWVSVLAMNIMIIKKLNKTNKKMADKKTNASVMKSKQSENQITRLLLTVTFTFLFFIGLQCIIQCFAMRQPSWADMTKVSSAFAFAKTGVVFNSSTNFLLYCLTGRRFRKELAKMLGCSKRGSSQLSSLIDHPSSGPTSGASTTSTTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN57</accession>
    <name>A0ABM0JN57_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101848201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097593.1">
        <property type="nucleotide sequence ID" value="XM_005097536.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848201"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="69"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005097593.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24764" checksum="B927B57D8BF21945" modified="2025-10-08" version="1">MADVGTVDFHDEVVDVPLEGDIDVPGAAKSDDELSTLDEPVRITILRDLRAVGNKFWHVLIPKKSSVLLKEWDLWGPLVLCTFLAIMLQGSAEEVDEMKNNDGGPQFAEVFVIYWMGAAVVTLNIKLLGGNISFFQSICVLGYCVSPLAIALVICRILLAVSVDSVAVFIVRFLFVILGFGWSTFASTAFLSESQPVGRKLLAMYPLFMFYFVISWLIISHTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNG3</accession>
    <name>A0ABM0JNG3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase</fullName>
            <ecNumber evidence="11">2.4.2.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101857110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1-&gt;3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56064"/>
            <dbReference type="Rhea" id="RHEA-COMP:14610"/>
            <dbReference type="Rhea" id="RHEA-COMP:14611"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:140575"/>
            <dbReference type="ChEBI" id="CHEBI:140576"/>
            <dbReference type="EC" id="2.4.2.42"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.42" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005097805.1">
        <property type="nucleotide sequence ID" value="XM_005097748.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857110"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051993">
        <property type="entry name" value="Glycosyltransferase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46012">
        <property type="entry name" value="IP22168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46012:SF2">
        <property type="entry name" value="IP22168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="499"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="506"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005097805.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="66793" checksum="9D70E4A257384014" modified="2025-10-08" version="1">MHRRMLFKIGVTFVVGVGILLFYLVHVEHENKPDHPYYAQKKVGNSQFPVEETSNTVDSDFSVKVVLSEVVRDKPVEADFPTSSSGGASQHSIQDIIPIGDRNSDRNVRYSSEKKFGDEVEPSVMRKDHAEENVAEMHKLSPVFHSKQPLGFAIHLCVVACGNRSEEVMTMLKSAVLTTPHTVNLVFHIITEPSLQSYFKDHLEFWPRAYTQSLSFNIYSVTFPEDTTKDAWRKLFKPCASQRLFLPSLLTSVDSLIYVDTDVLFLQSVADLWSRFSLFNATQLVALVPESEDFQTGWYNRFATHPYYGDLGVNSGVMLMNLTRLRSTRWHLDMPELYNKYRLSIPWGDQDLINIYFARHPDQLYVMGCEWNYRSDHCKYMSVCPSAEKRGVAVLHGSKRGFLVEKQPAFAAVYNVFHNHRLGDNFEIHFLKHLEEELKAAKPSNCGKVSNAFLMRLRDVVEVENSRMTSGQEYPKVSINSQPSKNLIKSGLKSVDTRMQKQVHGGQEKVSGRFTDSSRTKTGKVHDRRITVRSDPKLTVKSNGKPEVELKSGSLHRARDIAKMEEANKQYDDDSDTVEKLKDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNS7</accession>
    <name>A0ABM0JNS7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock cognate 71 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100533359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098012.1">
        <property type="nucleotide sequence ID" value="XM_005097955.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100533359"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005098012.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="71389" checksum="3DD5810B54F4C052" modified="2025-10-08" version="1">MSKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDNERLIGDAAKNQVAMNPENTVFDAKRLIGRKWDEPCVASDMKHWPFNVINEGGKPKISVDYKGESKLFFPEEISSMVLTKMKETAEAYLGKTVTDAVVTVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKVGTERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIQEFKRKHKKDIADNKRAVRRLRTACERAKRTLSSSTQANIEIDSLFEGIDFYTTITRARFEELNADLFRGTLEPVEKSMRDAKMDKSQVHEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEQVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAADKSTGKENKITITNDKGRLSKEEIERMVNDAEKYKNEDEKQKTRISAKNGLESYAFHMKSTVEDEKLKDKLGEDDKKTIIDKCNDVISWLDANQLAEQDEFEHKQKELEGVCNPIITKLYQGMGGAPGAGGMPDFSGAGGAPGAGGAPDAGSGGSGPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNZ7</accession>
    <name>A0ABM0JNZ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PiggyBac transposable element-derived protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098137.1">
        <property type="nucleotide sequence ID" value="XM_005098080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855099"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098137.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24767" checksum="145B4431524466A7" modified="2025-10-08" version="1">MKGKKVVKTKEDVKVMTDGKLTHIKWMYKKEINVLTTIHDASSQCTDRHDRDGNPDDKFKALIDHNKYMGAVDRSDQMVQYSSFKRRTMKCWTKLFIHLFMLAELNAYLLYKATAVANRGTAISHRTFCHMMCKEMVSFAPIQDARRRILPSPGADQLHMLTGRHFPSKVPNQGQKRKQPYMNSFVCSKTSQRRRQPKSCTKESVNDHRVQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ60</accession>
    <name>A0ABM0JQ60_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Protein patched homolog 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101863023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098948.1">
        <property type="nucleotide sequence ID" value="XM_005098891.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098949.1">
        <property type="nucleotide sequence ID" value="XM_005098892.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863023"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF130">
        <property type="entry name" value="PATCHED DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="764"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="288"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="743"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005098948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005098949.1"/>
        </source>
    </evidence>
    <sequence length="968" mass="106305" checksum="BA5225C10C859BE7" modified="2025-10-08" version="1">MSGTSDLKHSANGVHSNGHAPNGDVNGGTSERKVSCLQRFSNVITGGLEKGFERIGLSIGTHPWRYILGCVIVAALTGLGLLAFNEVSDPDKLWVPNDAQVLRDKDWISANYPSTVVREQIIAVGQGNNILTPSGISALLDIYQNSTTISTSNGITLSDVCLKAGANCLVYSVLEIWSYNDATIRSLTQDEIVDAVNNVNTSALYGSSFDITTYLGSRTTNSSGHITAAAAASMVWLTEGNETMESTTEAWEAKFLELGQAGHADLASTYVFARRSFSDESGDAIQGDVMLLSIGYFIVIIFVFLVLGKFNQLEQRIWLSLGGFICVGFSMLVSIGLSSAFQQDYGPLQSVLPFLLLGIGVDDMFVIMGALNNLRPDEQGYDIPHKMADVLRHAGVSITVTSLTDFVAFMIGATTIIPALRSFCIYAGVGIIALYVFQALFFSACLTLDLRRMEAGRNACCCCVKHDLPYEPNKCSQKQFLPYVFKQGLAKLITKLPFKIFVVTVAAAMFGVNVWGLVELEQYFNPNWFLPQDSYAYAFTEASEQHFPDDGASGFVYCGNLNYWSRQTEVETMDSAMANSKWIYTGTTDSWFSALTTWLASTSDATVTPLLDANKYPVSEDAFINLTYKMTTQIQQRTSSYLKFSSSTGSDILVSRFPFRHIDMDDASTEIDAMDSTRELVMAAGFSNAECFPYSRRYLTWETNKVIREELYRNLALALACVFLVTLILIANLWTSLMVFAGVLFTLVDVAGSMHFWGLTVDTVTSIILILSIGLAVDYSAHIGHMFMTVVGTRTARTKETVGEMGPPVFYGGFSTFLAFVLLSNSNSYVFQTFFKVNFLVVVYGLFHGLIFLPVILSWFGPEPYPTADRVYRHHHEHHPDVEKVDGVDNRGFSKNGEGSKVGGYELPPLRNAPTGANTAQEVTDLNVQNGRDSMTPPPSYTSKNSGTPPPDYSPEGGRRHFMPSVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQT8</accession>
    <name>A0ABM0JQT8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase S6KL-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101847040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099383.1">
        <property type="nucleotide sequence ID" value="XM_005099326.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847040"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005099383.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25462" checksum="C648AFC924AF2207" modified="2025-10-08" version="1">MAMKKVDEHAAAFDALNLNRGTLVGKGATADVVLASSRDDVSRKCAVKIFDLAKYDGCNEWGFIKEVDFLKELSHPRIVSLVTSFANPRHGYIVLKYYPRGSLDAKFRFLEPPQVLRYIRDIGTALEYTHSRGIYHRDIKPANVLVDEEDHAVLCDFGLSGRLKNGDTKVTRWNTSLGFHGPETKKGQAMCPYKKHKEHRYHHKQIPFFMTSFALNITYVTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRE2</accession>
    <name>A0ABM0JRE2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ficolin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099766.2">
        <property type="nucleotide sequence ID" value="XM_005099709.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858496"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099766.2"/>
        </source>
    </evidence>
    <sequence length="221" mass="25147" checksum="C44C0EEFC9D01EA1" modified="2025-10-08" version="1">MWQPWTNDVTVQLACSSGPHTCADVQGSNPRPVVTLSNGLEVVCDTVTDNGGWIVMQRRASADVDFYLKWVDYKYGFGDVYGNFWLGLEKVHQLTFKRRYELRVDITFNGQDYYANYDNFTLFGEAENYTIRVSGYSGNSSDGLTYHNDQPFTTKDRDNDAKSSDNCAVEYHGAWWYKACHDSNLNGKWGSQEYGEGLVWGTTTGDYDSATFTEMKIRPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRX0</accession>
    <name>A0ABM0JRX0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101845102</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100136.1">
        <property type="nucleotide sequence ID" value="XM_005100079.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845102"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052613">
        <property type="entry name" value="LicD_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627:SF32">
        <property type="entry name" value="AGAP006029-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627">
        <property type="entry name" value="FUKUTIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100136.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27813" checksum="85BBBF275FE4D711" modified="2025-10-08" version="1">MRMLEFLRRFAPRVPWSIVFSLFIAFIISFYMMFTIMNDRFMHHQNWYDFPAPCSRPKDMLDAMAKLAFTASDVLTQLNVSHALCYGTLWGALRNGEILPWDNNVDVCVMREQIQRPGWHNLHKAFQSRNLPIVYDYRHGEYSIVDGSAEVVINVFYSTVWEEVLHDGWEHRFLWFFQDQPVSFPRRLLALPLPKIKFHGKDMPIPHDDLEMLKYLYRDNWWLVKTPPGCPPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTG6</accession>
    <name>A0ABM0JTG6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUAK family SNF1-like kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101848121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101084.1">
        <property type="nucleotide sequence ID" value="XM_005101027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848121"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005101084.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36160" checksum="2E7B77F099B631E6" modified="2025-10-08" version="1">MSTKMNFQPWECNVASVSPEQALGLKRDANIALGFYCYVIRVADVNDPSRKMAFKRLKFLEDENGYRCQRFLFYNEVRFLKNVQHPNIIQVEQALVCPGEFVIVTEYHPTNLFNDLRRHTQAEVSKYFSQVVDALLYLHDRHIVHGDVNLQNVLIDTQGNAKLCDFGMAQFVPNKSSKHWGCYSTIYYDGPEYIRGRPVEDAFKLESFSLGVCLCALSLRVYPRKDLNYLELLRAGESVPDIHRVCAERLLCPSPAERASISEIHQRLNDHRQSESRAQSDVIHESPAPVSVPTPSECSHVTEEYRNFILEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW08</accession>
    <name>A0ABM0JW08_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellum-associated coiled-coil domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102826.2">
        <property type="nucleotide sequence ID" value="XM_005102769.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850820"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026674">
        <property type="entry name" value="FLACC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21707">
        <property type="entry name" value="FLAGELLUM-ASSOCIATED COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21707:SF42">
        <property type="entry name" value="FLAGELLUM-ASSOCIATED COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005102826.2"/>
        </source>
    </evidence>
    <sequence length="538" mass="62042" checksum="8ECDDAF2E3BD6014" modified="2025-10-08" version="1">MNRTMPSEHGTVYSDSIGFDHQFGGPAPHSGRPSSALNNSNSHNLRWGHRPKSTPISASPRHGPGYPASKISRPKTAAVILGRTDCDRVQQLEHEPTRRHNLENHLPPKRTKPPPWQKNLETPLVPFVVGPGYILSRSKTKCHVTIKDEFFDPIFEENNKKKPQGDPERFFRKSVYYSEEFLKDKVDQMTSTHQEHVRDMDLEHREDMLKQKRQMEEDHREAQASLEKQIARMAKEIEFLQGAFESYKSTLHMETADKWNSREAELKQKCADEKQQALHDLKMRLTKERNQEMASTNREHSKAMEALRKENKREMDSLIRRFSNAAGDIEKLRKTTAELEETKSELDQLKEAYNETCIKLTSTTRMLTDAKVRLMDFEERFQERVAQVDDKYRHKLEELMTQNTELKRLFVQKCGELFDEKSNTDNQTSQRVKTAKEAMETLIKSKQRANVNLAVGGPLDKIRGGKTRPLSAPGTRSETHKAHVTAGETDAHPTKREFIPPDVNVDSNPETEEMRAELFSGPVRELSKEELLKSMSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWA2</accession>
    <name>A0ABM0JWA2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myb-like protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103008.2">
        <property type="nucleotide sequence ID" value="XM_005102951.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855120"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045077000" evidence="3">
        <location>
            <begin position="26"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005103008.2"/>
        </source>
    </evidence>
    <sequence length="628" mass="68337" checksum="A2EF31098923AF3E" modified="2025-10-08" version="1">MDAIRAWSSLAVVFFLTVRTPCVQSCDIHFDLEGPSLLLLAGDNASLLCDATCFGDAENTDVIWRNDNGQIIGSTPNSLFTVSYYRGLRNRLLILRASSDVTGTYICSVMRRGSVISQRWKSIIVYGGEDSDNSEDNSLLTNTGPRRGDLRPHPEFWFRYRPVRSARTHAHIHKRQVAMEPTTAATAATARTAAASSGASERPGTSTGTQDTSRRYPNTSPLTITPSRKRVTSTGRPMTSYRTTTTTTSARPRMTSWTSSISTAGPGWLTDRGTQTYPPMPQTTTLSRSTTKPSETMTTTITKTTVSMTPKVVPTQRTSTAKAESVWRSTTVKAYGSNNNIGSSSSGNNNNNNNNDNNNNNNNSNNNNNNSNNNGNKVTDTSTSDSKTGQSHGDHTDCPSPEGPTTDFGRHGVLAFSISLAIAFLLLYAILMIIFVPRIMSRRMKMDKKNRRKQSPEIPGMFTSLTGHSDLASDPGILLTAPEKGTATPCAIEVVDEKDKGEDRPSSDLDNKVSTFLLRQASQKGTENDSNSNYETQQNNMAEIEKTATEKNEQTSRPNETTPTEQTTPIETTPTNETTTTKQTTPIETTPTNETTPTGEAVLDKSPESTANDDVKNAMSDVEATSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWH4</accession>
    <name>A0ABM0JWH4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Coiled-coil domain-containing protein 124</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101849708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103156.1">
        <property type="nucleotide sequence ID" value="XM_005103099.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012940689.1">
        <property type="nucleotide sequence ID" value="XM_013085235.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849708"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="5">
        <location>
            <begin position="127"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005103156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012940689.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24845" checksum="FB5F424AB7012335" modified="2025-10-08" version="1">MPKKFKGENSKAAEARARKDAVQKAEKERVEKEKEDALWADDDKHNARKLQRKDDKEKKRLEQLERKKELQQLHEEEMSSIKGAKAQAAKVSRAQILENQERAAAEAKAEKAKEQLSHDEVPLEENVNLLVTEGEDARTVDDAIAMLSVAEPSLDKHPEKRVKAAYSEFEALRLPVLKQENPNMRLSQLKQMLKKEWMKSPENPLNQRHSSYNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZI5</accession>
    <name>A0ABM0JZI5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105201.1">
        <property type="nucleotide sequence ID" value="XM_005105144.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847832"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="9"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005105201.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="34548" checksum="562B90DAB56F1F7E" modified="2025-10-08" version="1">MLSQIRARVFVSRRIPPKALQMLQAGCDVNCWDSDEPPSRKGYLDSVRGIDALFCLLTDKIDAELLDAAGPGLKVVSTMSVGHDHIDLQECKARKITVGYTPGILTSATAELTVALLLATSRRLKEGMRAVVNGEWGTWKPTWLCGSGLDGSTVGIVGLGRIGIAVAQCLKPFGVAQFLYSGRSEKPEAESIKAKFVPFDDLLQTSDFVIACCALTQDTAGLFNKDAFSKMKKSAIFVNSSRGGVVNQEDLLHALTSGEIAGAGLDVTSPEPLPTDNPLLKLDNCVVLPHIGSATYSTREAMAVLAAENLLAGVRGEPMPCQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1M7</accession>
    <name>A0ABM0K1M7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter F family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106641.1">
        <property type="nucleotide sequence ID" value="XM_005106584.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862212"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF27">
        <property type="entry name" value="PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106641.1"/>
        </source>
    </evidence>
    <sequence length="674" mass="74355" checksum="3704B7F9AA876136" modified="2025-10-08" version="1">MALLAEAKRKTKYGLDPRNTTWSNDESKFGQKLMEKMGWTKGKGLGANEDGMVDHIKASYKSDSRGLGCTPKDADAWIAHQDDFNDLLKTLNSETGGESAPAKTDEKADGRKRFYGRFARGRVPTLRSTEDLDCIFGKRKSAASTDSPAKESTDSSDSSDSDDEGSDDKTDKEEKSHGLTTVTSTSSVQEYFARKMAEKRARQAAGGTSGGQDSPDSEKERDKSENPRQGGGENSSKAPAVFGAVAFCYDNGGDNKELKQEGGDAQTSSDVRDEDIQQSRGWYENFPENAGLNEKSEDLDTSKTKKKKKKKDKKDDREEPDLSDVKTKKEKKSSKKADQCDNDCAVSVEDVSLEDDAGKSAGKKEKKKKSKNVSEDAELSQEENAGLTEKTKKRKSKELSVEEDGSEAVPKKKKRKLDESSDVLPEGDPGQDCEAQEKVKKKRKKGSEKSTENDEEADSVDDKSSDDAHSKKKKKKKSRNVKDDSLENSAELETESERKAGGSKEERKKKGKNVTFELGEEEEDADSSKALDTESNDKSKKKRKSKKESESPAEGEVCNDAADAQTEVPKKKKKSKGDNDVKPDTPPAEESTGEKECENTDADSRVSEGRNAENEKLQRKERKKKQKSKKEAKNLTAEEISVQNAFAGSNISEIPGYTNTDKTSTKNKRKKEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K222</accession>
    <name>A0ABM0K222_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005106920.3">
        <property type="nucleotide sequence ID" value="XM_005106863.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845192"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027756">
        <property type="entry name" value="Ovo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032:SF271">
        <property type="entry name" value="RH12261P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032">
        <property type="entry name" value="ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="695"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="467"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005106920.3"/>
        </source>
    </evidence>
    <sequence length="775" mass="85318" checksum="86921AA3CBB8965F" modified="2025-10-08" version="1">MQPSDPACSILERRNSPHNSQGCEESHRLYGQLSETNKSCFTHPSSVPGVYSSTTAPIIACVQSSSLDFLQRHHNSRISVKEEIPVSESPVPQRCPPPSLSSSNTWKTPDTNITSPSSSAPHPPGPHKPARAKMSFSISSLIGNEEKDTEAVDTSENFVNQINKCQDNHKCEVKQFLPRQSDMDQYSNSKTPEPKVKSSENLSVSTSFSNRILKACSQVDHLSSLPQPRESSYSEDSLSTQNSIRGDSHQAESKSSKCASLEINSSYHRYKVETSSSVSRVQESQNTAPVVRSPSDETNDSSNYTSDTPPQPSAFSEISPRPECHQNLSTNIAPPPDVQKDPSALPSIPGTQENHFPSYRPYFQEMNGSLSKPLVSPAVKDYDLRLPVPPSPLSVTDHPMTHRYVLPGHLWQRLPVRASLYQPFPMRFEARDPQFNVHNPLLTPLHASTETPQKIFLSSNIRPHYQSPAYVGHGPDTLPAVVGVSTGQHTVSQSEDTSPRSDTTNGSLPSSSSSSASSGLLSPTSPAPSSAHSDILSPVKAGHADVTALSSHVISQPGHAPGHPDQCPSLSRTSLDGLRWNVGRPGKDESQEGKSFKTFLENANVRIEFINSGNGIKNPLLSTEFTDNKLGLVSGNRSLPCPVCQLTFDSPKHLQRHFKSHKEIKRFLCTFCGKGFNDTFDLKRHTRTHTGVRPYRCSHCDKAFTQRCSLESHCRKIHGLAEELAFNERRVKLYVCEDCGHSTDLADEHYAHVRHAHSQRHAPLKRNVNIEVAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K257</accession>
    <name>A0ABM0K257_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101856458</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106970.2">
        <property type="nucleotide sequence ID" value="XM_005106913.2"/>
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        <name type="scientific">Aplysia californica</name>
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            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2R8</accession>
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        <name type="scientific">Aplysia californica</name>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107417.1">
        <property type="nucleotide sequence ID" value="XM_005107360.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862828"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="341"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005107417.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44467" checksum="90AA1A388E2E3721" modified="2025-10-08" version="1">MGVNLDSGVSQRSKTKEDQELRDMSIIDLTKSAREDLVVQVLHDNPSSCLLVDEEERTALHWAVEFGYARLTQLLVSAQLPTDASTATKGGFLNKRDSKGHTALHIACNAKRSDIASLLVTLKADLSATDQSGNTPLHRAVRNNLETTSILMCEYGADVNARNELQWTPLHEATRTGNENLLQVLIKHGADTNAVTHNHMSPFLTAFFYYKIASKGNSYPNLDNIWKVLIESGCQLSQSDGHWTPLTAAIACDNTFIAALLLFNGCQLAREGRWGRGMLQETFSCGEPMLVKLLVLLGYLPSPEEVQYCSKQIPMYSKVFTRLAGLGSGLHRDRQAVVTWLKQRELEPPSLAEWCRVSVRQAMNVSSGDRSFIGNIKELPLPNKLKQFIAMSDFTHYLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2S3</accession>
    <name>A0ABM0K2S3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101846089</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107429.2">
        <property type="nucleotide sequence ID" value="XM_005107372.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846089"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037939">
        <property type="entry name" value="CRADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034:SF5">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107429.2"/>
        </source>
    </evidence>
    <sequence length="171" mass="19227" checksum="C17C6017BB71EE38" modified="2025-10-08" version="1">MNEGQRAALKRYHQRLAEDIIVSEDLLGELYQVGIFEKGMIDMIRAERASDQVHKLLVLLPKRGPEAFERFVAVIERDYPWLATALLSAPTKTAAPATESLTHSRHTALGHHSKPLSSSTPALQDGVDGDIKKLVAAFIHRQFGQSKRISEKDKKSLEKFVNGQIQRERTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K454</accession>
    <name>A0ABM0K454_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Death-associated protein kinase dapk-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101856925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005108326.1">
        <property type="nucleotide sequence ID" value="XM_005108269.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856925"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039788">
        <property type="entry name" value="NOL4/NOL4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449:SF18">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="7">
        <location>
            <begin position="200"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="6">
        <location>
            <begin position="814"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005108326.1"/>
        </source>
    </evidence>
    <sequence length="932" mass="103821" checksum="DB00BDA7C873EEFB" modified="2025-10-08" version="1">MHCAAWHGYVPIVRIFCENGAMLSLQNKEKETALHCAAVRGNIDCVRILLENQAPLNVTDKRGSTPLHLACQRHNAAIALLILNAGCKLDIIDKETGESALHCAAREGLLHVVQTLCSLGADVDQVTEDGLTPLHLACKSGHIEIARSLLFVGANPDAVNKDGVTGEIMALAQGYTNIAELLNSVKGEKRLALISQLKLSPQPIPRVKLKLLGSTGVGKSTLVESLKCGFLGSFFRRRTHAPSPSVKSKTRSRLSRQFSLPTPLNYTVGNPSYTKGIDVQNITISGTGEWSIWDFSGYEPYYMLYDHFLGDVHCAHVVMFNLQDSLDEQMAQVVFWLNFLKARIHPKMPIDHCGKLQNTGQVVLVATHADKATTPTQKSSSGSGLHTSEDAQYILEKVLTMFQYDLDICPQVYVMDTQLPSSVDMRAFKHQLGKMRKSLSDKIPRSNGFLSAVVAQLPEWRKALASYPVLSWPQFSEHVRGCVNPLASDEDVKLLDRQLQLMGEIVYLHSHTDLVVVSPRWLGVDVLGHIMSHERIAQARVIGCFSLDEFQLMYPSTDALSLLQVLEALEMCTPCEVDGDVEYEFPCLNFVEALEGLWLRDEKRFQSPVYGGVRLHTSFQSGAQLKYLFPRIQVCLRRSILSGDEEQEEEGDSSGDEEHRVKEEQKDADLYQWHHGSKYCCARLEGIIDMDRNEQFLEIKVRGPEGERANLYYFLEDFVNIVEQVVENVCPGLCVERYTLSPSQLSEHGKVVRSYSPTELLRMQLENRSSVVLSGNLKEDFIDIACLGSEEILETVTLGMDLPISHLTVHTQRLLSLLLDPPEAMGKDWCLLAVSLGLSDALPSLEATEETGEGTCVSQTQKVLSEWTRRHNDASIRQLVYKLKEISRLDAVEAILRTGPPFKVLSFEDQMTDSTGTHGTNASTNTLSNLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K576</accession>
    <name>A0ABM0K576_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 117</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101845652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109032.2">
        <property type="nucleotide sequence ID" value="XM_005108975.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845652"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029370">
        <property type="entry name" value="TMEM117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31226">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31226:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15113">
        <property type="entry name" value="TMEM117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109032.2"/>
        </source>
    </evidence>
    <sequence length="764" mass="87348" checksum="84F2B5BA893BE60F" modified="2025-10-08" version="1">MTKIEDKIVLSPKSAKSSVNDAQDGGQESGSYNNSALEEEEDCYAVGRTATPLPKITKVEGLCIVESDLPVTQTSDRNNNADQSVGGTEMKKLSRKKVTDEQSLEENKPLKISVQRVRKGRGESMEDDTRMEDINLRDDDGDVETAAAASNEDGDAFDKLESGGRKNVTPAFESAVEAFVSRNGKNGKPDRNKPQDEGGGDRAESGGETRPKPVPFYISNGAGRTDSSEIATKDDVDAGSVYSLFMEKDFRYHFQHPYFRIFTAYFVTFCNFLIYAEDPVAHSRQECNIPVIGNDFSFVCMKWLPNAWSLLKVLLWITGTLVGLIIGKIVFHTLLFNRVLRLKMFHDDKGSWMTMFLSTILFVFIFSYVYNAFLLIGGDYTDPYHISSFMGINNDIFMKAAATGTWCGDFFTAWMVTDMMLQEKLYPSWAKPVRKWWNTSYNRIILFWIIVVLSSFTVLFVIATDYINWDSLNRDFLHSNEISRAFLASFILVLDLTIVMQDWDFPHFISAIDIKLPGLNMAHIRFEIPKLLKKVEYWQVHISGKWFNYGILFIVIILDLNMWKNQIFYSPFDYGQYVDSEGRIHTVTDRFSLDNANESILTFDYRNVTINPDTGQRYILGDTMMNARYNGYSMGLKGMAFVPSIAVFLLFGIFVWIYGRRPKPTQENPYGGRLRKRRRRRFSARKKWNSIRMWFRGAAPVLTRFRSRREERAAARTAEEGGNNREDVGESRKDGESAERVEERRVARGEGGEEDHSTTQEVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5N8</accession>
    <name>A0ABM0K5N8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005109324.3">
        <property type="nucleotide sequence ID" value="XM_005109267.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852730"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109324.3"/>
        </source>
    </evidence>
    <sequence length="272" mass="31618" checksum="FCF345A7934007EB" modified="2025-10-08" version="1">MVLRHMQMRTKQKMAAPMEEIVEFHSFYYLKLLLLLYITISCILYISVQFVYQNKRIPHNQNILLITAHPDDECMFFAPSLLELGTVNSLSVVCVTTGNYYGQGEVRKKEILKSCEVLGICKHDVHVLDDSSFPDDPKVEWDLLKLQQEIQSFVSQYKPSIILTFDHGGVSGHPNHKAMSQVVRIMYAEKKFPNSTVVLELDSVSLLRKYISFLDLPMSLHSSHWTFISSLPSVFRAQKAMRAHCSQLEWFRYLYIVFSRYMFINTFTEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K658</accession>
    <name>A0ABM0K658_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neurofilament heavy polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109647.2">
        <property type="nucleotide sequence ID" value="XM_005109590.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847691"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005109647.2"/>
        </source>
    </evidence>
    <sequence length="312" mass="34598" checksum="90F2A8C78CD7854D" modified="2025-10-08" version="1">MANCRGIWKLIYVDCFKEYLDQIDVSEENQTRALQLLTPGNDITQDIRVLEDDVIIKTFTPVASMEVAAKLGVPFESLYLDGRTIKTVFSEEDGKLIETLTGPFSTRIVRDLQDDVMIMTMTSGEVTSTRKYSKVEPTNAAEDSEKTSAGESKTSTPVTDPNTEPGESSEKESQEPPTPESNTTPAETSEQTLSKEQPGQEPEEEGSEPAPIKEESEPAKEESGPVKETSEPVKEESEPVEKESEPVKEESEPVKEESEPVEKESEPVKEESEPVEKVSEPVKEESEKVKEESEPVKEESPQAAPQNKETEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K801</accession>
    <name>A0ABM0K801_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin-depolymerizing factor 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110965.1">
        <property type="nucleotide sequence ID" value="XM_005110908.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847460"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="4">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005110965.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20489" checksum="D7A4477841A3CC62" modified="2025-10-08" version="1">MTEISEAAMTAFEEMKQYECYQYVIFKLSGDFSTILLDEIASPDKTYDDFTSVLRPSDELMEASGTGECRLAMVKISVDTSPENSPVASSSSVSANSSLGNSSTASSSSGNASANNNIDNESVIACILWLPFRCEIPEKMRYISAKEYLHTEMQWTGRTVYCERRKDLDIAKIQREMRFDFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8C5</accession>
    <name>A0ABM0K8C5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Resistance to inhibitors of cholinesterase protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ric-3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111195.1">
        <property type="nucleotide sequence ID" value="XM_005111138.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864108"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026160">
        <property type="entry name" value="Ric3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032763">
        <property type="entry name" value="RIC3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723:SF3">
        <property type="entry name" value="PROTEIN RIC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723">
        <property type="entry name" value="RESISTANCE TO INHIBITORS OF CHOLINESTERASE PROTEIN 3 RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15361">
        <property type="entry name" value="RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Resistance to inhibitors of cholinesterase protein 3 N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005111195.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43454" checksum="5C64DF2D10E4F13F" modified="2025-10-08" version="1">MSTLKTIGTVAIMVACFAVIYPRFMHPLILRAFGLNDPPNKHVEENTMYPPGFNKGHRPPGDKKADSVTEDIKRHMRHGPHPGMRAAAEMQRQQSQQGSGRGMMGVVLPMYAIGIVLYLVYTLFKVFNKSKKTNNNNSSNSTVSPWAAQGPTSYSRRGESSHDRMGFPADFDGSSDVRSFLQDRQQRKDLEDLLTRVDDKNVSVEEMRILQRRLEETEAQMTRILQAMQSVQSNVDHMAGPEMTDGMAAATDDADAAAPNAPQTKSNDSSPDMDSYEVVDKNEDGKKVEGDEEGSMPVTKKKQEARGGEEVKEGGEEKKEGKREVNLDGIDSEEEEEESGEKNDERDADEEEEEEAVVEEESSERKIPEMKEEEEDTSVRQRKMNAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8D3</accession>
    <name>A0ABM0K8D3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">E3 ubiquitin-protein ligase lubel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101849805</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RBR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111217.1">
        <property type="nucleotide sequence ID" value="XM_005111160.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849805"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20337">
        <property type="entry name" value="BRcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16631">
        <property type="entry name" value="mRING-HC-C4C4_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20351">
        <property type="entry name" value="Rcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047540">
        <property type="entry name" value="BRcat_RBR_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047542">
        <property type="entry name" value="Rcat_RBR_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026254">
        <property type="entry name" value="RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032065">
        <property type="entry name" value="RNF31-UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041031">
        <property type="entry name" value="RNF31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047541">
        <property type="entry name" value="RNF31_RBR_mRING-HC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057426">
        <property type="entry name" value="RNF31_UBA_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LUBEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004">
        <property type="entry name" value="RING FINGER PROTEIN 31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18091">
        <property type="entry name" value="E3_UbLigase_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16678">
        <property type="entry name" value="UBA_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25163">
        <property type="entry name" value="UBA_RNF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="1516"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1520"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="908"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1158"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="776"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1170"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1208"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1220"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005111217.1"/>
        </source>
    </evidence>
    <sequence length="1884" mass="209648" checksum="FA7551DF2DEE5632" modified="2025-10-08" version="1">MSQSVKKAFGFVWKTMMQQLSQDSTDEDRPLEDVRAEIVELIRTGQDPADVMEELILQDYQLNDKYAILDVKQLLKWNDEGMQGLQHVQQALGFILKYARHLTKALPERSQQWREIRFTNVHVESKIKPMKGFEAVLEQLGYTEPHQHGLRFPDGCEPDVRQVHNIIADIILFRKELGIYIQGNHPHHDYIDSLLTQNTKDELLAFKLSGQQCDEEEGMDMSLFPPTRQDTYRRPLRPAPPPPVQNVLPANSLEGGAATVKQSSSVDTIQASASVVETGNDNFGMSGNVLLDPDKTEVVSSTAQENTEEEVVECIQDLVDAGPDLPTGLNSSGGQHTSSSSFISKLVCDVCGDDAVAFCVECQRKTLCDGCNVRWHQHPHRRGHKIQQISTVSSFTLDGDGSGVLIDGAYGVSAQDKQGPQRVKVPSRKSPRNSDSPSQPDADYQANTMIPDQIAAGNDLYPGPSDHQLLDYQQHLHQQSRPHTPTPQLPGYVGGRQMAGQFRSEAPYPSSHYASPVVGGNVLGHTPPGPFSAQPNQMYPPQHQVLMGAHGAGEQPGLYGLEGLVYPSRVPYTHTSAATGPNMQQMLPQMPEYIAQQIHNQSAKTAHPSQGHFNMINNNNSNAANNPLLYGANRLDPAKSQPPYPYPMQGYPQTDTYPMQSLYPATRIQPHPNSERLSYPYPGVVPTVGSSSLCYMEYPSQQRPLLAPELAGNPVAMGGGTSLAPYPSHMHPVNNYDVKERRPSLHSSSSSVSTSSVSQSKFVARLMQESDPETKRRKCELHIENLQADIQDLDAEINDRMTDDDNEFIESEEFKDMSKRKSCLMKEKKMLENFRKQMDEETQVVKLNPQLHRHLQFQRAAAQQTIYYPPSLDQPIANLVNVHGSVKSQPDAAAPASNHVLTGTVPLAEVSSSTDRVQGQPREEKILNTAPQQVSQTPPKKAPHGPPPPRPPPISAVSSTAGAIRPPVQAAKVPVENSFSDETIPVAVEPRVAPPALPPRPNIPPPSAAWDDRLDITFPPPKISNTEIVKPKPWHCEHCTFINQASSHACEMCHKTSDNPQLVSITSSMSLSSEISTTELEEQTSDENSEFGSDRFIAMLSELNQDESQIHSNLIKSKEVGARIAGIQDEVMKEKKKAQQQFQQQQQQYQELYGQGGLPQFAGSAQPGNLQQLAASPRQASPSSQGAMLRAPSPSSLPSSGARNKVPSSTTDLTSSSASGDFQTPPSRVSPTPAGPAIGADGVAGEGTVEELLGRLDQAKLIDSVEAEGAQLAQWVKMADREGFEVDAMSIALAQCSLHSLDPVQWLRTNWTNNVTQVALRAGKKGREEDQNCVGELSLAEAKAAYMSCNGNIKEAVNLCVRNRKDLYGKLSALGEFPREEILDAMQQSCGDQAACEHFLQASKLYPFIGRIWAQRESECGDHFQLQNMTSSDMCRSFSTSVINHWDFQKIIRDKNVDLDRRTRMILVEGRLKSWGRAEMVISILDQGVPRTEVSLEDVVEAVRNCRDRQSALAYLQQECQICYATFPMSKIHSLNVCQCKLCAECLTLNFEVDIREKHVRQWTCPICSLPDLNDTDVASEYLHFLSMLLQPLIHEELHNLFETKIRDWHLQKDENFRWCAHCAAGFIADNRRLCMTCPACGLKTCYSCKKKWEDQHEGLTCEQFNQWKIDNDPTNQSVGLAKHLDQNGIDCPKCKMRFDLAKGGCMHFKCPECGHEFCSGCNEAYHHKNVCQKYKNCRQLGLHCHCPRDCFSYLRDNSVTQLQQLLKQNKVDFNVDIPSDQGDAQCPVMEQKELDRSSREEKCGKDTEPGHAGLCELHYKEYLTGIVNGHRIDPVSIMSQEEMLAMLRKYDVPVPNQKQNETPVVFAQRLVQVIREKLPLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8S2</accession>
    <name>A0ABM0K8S2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Toll-like receptor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101863152</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111527.1">
        <property type="nucleotide sequence ID" value="XM_005111470.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863152"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047120743" evidence="13">
        <location>
            <begin position="37"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="804"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="14">
        <location>
            <begin position="851"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005111527.1"/>
        </source>
    </evidence>
    <sequence length="995" mass="110739" checksum="3D7DCFD3A1F35512" modified="2025-10-08" version="1">MALGKSCCRRGDTECSLWLSGRLLCLLVALAPTVCAGVSRGVNGDVSRAVNGDLSRADYGDVSRGVNGDVSRGVNGDVSRGDNGGVSRGVNGDMSRGVNGDLSHDKQTDSSCVVSQVPEGAVVDCRAQALKDVPTHEIPQNAVELYLDDNSIQALHDNCFGQLPRLKVLTISQNHLKSIDGCAFCGLAGLKHLNLEKNQLDLSASMWGNEPFRGLSQLATLNLLDNENAVRQGEFHSRLLGGLHSLDTLSLDTFKGNLTFGQLFANMTSLHHLLLSGGVSTLGNNSFHSLHTLGLKELALNNVYNLYTTELDAFQYLPSLQSLTISNTHQGIEVTLRSLYPFRNRTMKTLYFYKIEKSQFEKGAAKCSDGVIDAFKAEFVSQICVERFSLTDSRVTTVESNTLSGAQWQKCVKYLDVSGNPLTGERSSLLQIMRFKALQELKISFRTTSTLKLSDNNLRKRQKEPHSSLKEWARSYNPEADKSLPVKVVHDQRKTMSLPTRFVPADEMEDRYLPTLTSHHSHDFTHNTSLGYREESHKGNSHSKENNVFYLRIPKTLIALYAESFTHASSTAAKEIHFVGGENLREMYLSDNNIVDFSGFIKGLRNLQVFDISKNDCSAMSATFFQFLVGIKTLKMKGNKLDSMFMSRHSEQLFRSLTFLKSLDLSDNQLNHLAGETFRDNSQLQTLNLANNRFTDIPLDLTLLPNLTDLDLSGNSISQLSKKGIAFVEQHARTVSEFSLQLSGNIVVCTCSSIPFLAWLQNTKVTLDRPMSYSCVTEDGRLTTTAEFADVRALWRKCHGGSALLFSIILLCLMSLGFLVTVLCWTLKTRLKSLVYRVFIQGFNLHGPADYRHGVFIGYADADTRLACFTLRDFIHSRLALSTYVRDINQLPASNMAESIVNAVNSSWRIVLIVTSDFLDRELWSYFTMTTAAYMVSPANPGLIVVLLEETVRHRLPASLLRSLEEDSILSIPPSRHLSQDNMRRLRDLLQPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8Y7</accession>
    <name>A0ABM0K8Y7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tripartite motif-containing protein 45-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111678.1">
        <property type="nucleotide sequence ID" value="XM_005111621.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860937"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="5">
        <location>
            <begin position="549"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005111678.1"/>
        </source>
    </evidence>
    <sequence length="727" mass="79958" checksum="B987C18D12E13964" modified="2025-10-08" version="1">MEAPNLSSQNGTLEEGNQEKSTSARNKRLRCGICGEKYRLPRILPCLHTFCTDCICSLQTYPANQEEASSSSDTDHTSDWLVPSTAGNSAENLLEEGDARTALTSSAADVSVVPKAAIPRGRSRHAKLIEKRIIRSNSCHENDATGEGHSSHRVNVVARSSNDLSNTLEGLNLAGASSVCFVNDVGERDNTEDLSIEETRVVLCPDCLREVKIPVNLDDLPRNFMMERLVAHDALTKATNNLRCDSCCDDDDDDDDDDGDADRDGGDGEQTRKSVTARCVECQENLCSLCEFSHRRQKKTKSHQLILLEYSLRTSNCNNSKSNGDISSCSNSNSTNSSMTTIPESVREEIFNQEKANPSHRPKVLKNITRLKLPNLQQFGKLLKDIGGSVGDVRHGDSGHGDGRHGDGERKDTTNSENQPRDEDLKVADDTPCDVSSSNDVSNIRPGMNSGLEHTTRLTKIPRTEREGQDFSKRKKISSSFWSREKLSTENISVNGDTSRRKKSPKEENGKVEGLTTARVLHACLMTLTVCDTEAVPYTGNDVRVRAWVIVQEQNIKSTPVTLTPFKDGIHQLSFTPTHKGTHFLHVAVNGEPVHVSDLFVLISPDTMLGTKDSPLRFNVKARWRRHDGVWQCCTFCTTSGRRDVICGCGATSPGGYLGCTHGQGSHPGGQHWSCCGKMNRDSECSGRPALGSRPSPMENQPVGVRATCRLNVHLCLWLKKSIRFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K974</accession>
    <name>A0ABM0K974_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Histone H3-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111878.3">
        <property type="nucleotide sequence ID" value="XM_005111821.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849980"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF17">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005111878.3"/>
        </source>
    </evidence>
    <sequence length="142" mass="15693" checksum="E01AF4E7D8DBD88E" modified="2025-10-08" version="1">MPRAAQKKAHVPQKRTSFGSSKSRVSPSSSPEDDDARYRAVAGRVSSSGSSTKVGSGSGRTRPTPASPQKRRRRPGTVALQEIRRFQKSTDLLLRKLPFARVVREVGAKVAPYSMQNLRWQSLAILCLQEVCLAAFDQVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K995</accession>
    <name>A0ABM0K995_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIF3-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111921.1">
        <property type="nucleotide sequence ID" value="XM_005111864.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860464"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017222">
        <property type="entry name" value="DUF34/NIF3_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037490">
        <property type="entry name" value="UCP037490_NIF3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111921.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43577" checksum="D238A9F2D7A700AB" modified="2025-10-08" version="1">MSLTLMIRSQRLITSSFRSKHKLKYQSPITLLSSQPWRTTGSLTMNSLDTVVAKLKKFAPLSLAGSWDNVGLLVEPSPPKYISKMMLTNDLTTAVVEEAKEKTVDLILSYHPPIFKPLKRLTQSSWKERVLIECAESRIAVFSPHTSYDAVEGGVNDWLLSAFDLKKGSVRPLEVSQTKDCRSHLFEVDVAADRLKEMRDEILVSCLPADSPLTAQKTAFSTVVLRSTGSEQLRLQVACNSSELNAIITALTLCKAPETYRVTPLSQIPRPAAGAGRVAELAEPLSLELLVSRVKTFLGLKHVAVAKAVGEEDPEVSSVAVCAGSGGSVLGGVPADLLLTGEMSHHEVLDAVHRGSSVILCHHSNTERGFLVPLRDKLSGLLGSSVDIFISETDRDPLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9C3</accession>
    <name>A0ABM0K9C3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="2">4.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-serine deaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101854839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005111981.1">
        <property type="nucleotide sequence ID" value="XM_005111924.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854839"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF14">
        <property type="entry name" value="L-SERINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="9">
        <location>
            <begin position="157"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005111981.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="48284" checksum="266C4D7BE99BEF4B" modified="2025-10-08" version="1">MEMESFLSFNYEADKPFRQETVGDIKKSDDSSSASSIGSSGMEWRLWPAISATTSFPYRLLDNVESFFKSKLPSLPAPVNQLQSVANSIASGLEKLNMDIDENIVTLEQVLEAHQFLKSSPDMVRTPTLLHVQSMFTKDVKGPKSSGLSSKVDATSLHKVDLFMKMENMQTTGSFKIRGVLNQMRKVKERHGKQCKLITMSAGNYGKAFAHCVGKSSPGSACVMPQTAPAHKAKLIENMGVEVHKVDTSKLMEEVNRLVKEEGFVFCHPFDDIDLIAGYASSALEVLEDVRNPDVILVCCGGGGLVSGVAAAVSLSKVSNCRVYAVEPQTAPTMYESFKTRRPVTIPHAKSVAAGLAPPYAGSLCYKHCRWFVEDVLLVSDEEMLSAMRVLFDRGIKAEPSGCAAFAALLSGKVPDVEGKKVVVYITGGNVSCSELSDIMQDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9S1</accession>
    <name>A0ABM0K9S1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101856071</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112335.1">
        <property type="nucleotide sequence ID" value="XM_005112278.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856071"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056589">
        <property type="entry name" value="WH_Egal-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23713">
        <property type="entry name" value="WHD_Egal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="241"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112335.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="62561" checksum="9A222CF6AE95839C" modified="2025-10-08" version="1">MADDPGHKAMLYFLEILMYSNAPMSISQLAGRFGSRNFTSEMRQSAGGNEAGLKKFLLKYPSLFSVNSNLVSLNDGTALGGSFRESSPASSSGHSCLPDVSTETEAVQFFRAKILKKGDKWMQVKSLAGHLSQALPEIRECVGPQNEFLGFLLKHPLIFEVRDDNVCLKDNIRCNAADSDSSSEPPALPPTTPKIKRRPKSQDVSEVNRPPPGGRTVTVAPAPISAVASKAGPVTMTANEYKAVMFIKNIIQKKGDMKVNSLSGHFSQAPESLRNTIGWSKPELHQFISAHDNIFTISEDEIVSVIKNTRLNVIITGSRPHVQTKPSVSGRKGQIFHVAKLWGIIDLGMHEHVFIDRTIFGKNIDDLNKLLKVGEWVFFDAVPAPKGSRARWKATKVWKENESIEDLIEKVAAKLDLPIDGFPREPQTPLGNMNDEIRKIYPDLDDSTFSNATPLNIGGIKYSFQDAAPSGAGVVPVWNFHHVELEGMKDVDELNFSDDEAEMSPRVSMVAERQYMNRSVILDNPRVPTVSEIMKNGTDSSSGKKCASVGCQTIVTGDVLATQLFHEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9S6</accession>
    <name>A0ABM0K9S6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101857759</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005112342.2">
        <property type="nucleotide sequence ID" value="XM_005112285.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15733">
        <property type="entry name" value="FYVE_MTMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14507">
        <property type="entry name" value="PTP-MTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046978">
        <property type="entry name" value="MTMR4_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF75">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="14">
        <location>
            <begin position="167"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="13">
        <location>
            <begin position="1285"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="287"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="633"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="763"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="828"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1053"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1083"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1229"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="880"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="916"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="966"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1002"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1123"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005112342.2"/>
        </source>
    </evidence>
    <sequence length="1364" mass="147011" checksum="F955E9FCA559651E" modified="2025-10-08" version="1">MPPFWMYCPEALDREHIIDVTTVPPCQKSSPGAQMPPFPLLLGEHPVLLSQTMEGQAMVTNFRFCVAERRAFLSVPLMSVGELVLVEANRWMRLGCKDGSTYCCTFATMEDGRVCYNTLREKVGVPRKMKDLFTFRFHAAALQREAAGGSCSQAESDQMALCKPVSQSFAYSFGKEVERLGFDTNRRRVWRMSHANDTYEFCPTYPKLHLLPVTVSDDKLKDSLDFRALKRFPSVVWRDKSSGMVLIRSSQPLSSFLGVSYFSNDADLLLLDEIVKACNRDWEFIQSERQPRMAPPPVEADENPGCCQGQGDGSARPEEDGAQGGLVGQGGGASTGHEASNGTDQHDSSNPRMLAIVDCRSTAGVWGNSFKGGGTEDEVVYKCKLIHLDLANIHAIRDSFNKLRTLCHNYPEGTYFKNLSGSMWLSYISQLLRGANIVVELMKGKRRPVLVHCSDGWDRTSQICSLSELLMDPYYRTIEGFQTLVEREWLHFGHKFGERGGHDPKCSDYNQQSPIFLQFLDCVHQLTRQHPAEFEFNEAYLIKLLKHSQACLFGTFLHNCQRERDACRFTYGSVWALLQPGNTRFLNLLYKPKQEVLVAKFSEHEVELWKSVYMEGHTSQTDIFLEPLLAADGEEGRDNNPAAEPMPRTRSMEELSRANADNTRRNSDPSVNPGQDSGAAADPHNTSSSSVEVLQHHAEDKTGSGSLPGDGSAGRVVDSAPASNGSATGLNGSSSSPAAVLAVSNPGASDQADVSVAQNNSVDSGLSVNTPLSLSSSSRNLLQDNAGGLTTGQSGGEDSAGVGGGSVVASLPVDNIPEGDEFLSCEQIPCEGEDAEGLSVRESAGGGGAEDGKKDSAISSGRELLSGAVAPGSPQKMRMSDSSSHISLLSERLAEVDETGGSVGNGQHLVSGHHQHSQDDSEALKSHDDNAAPSQTDGGDGAGDVVVQHSTSENSMTENGRKVESTHPSAGSSSSSTLAPSSVPSPATVRVYQQTSASPIPGRKVSSGTSSSTRKLSFSVISAEAPEQSPSSSSTSSASTVVGSKQLDVCTNTDKFVTSSPPPLSSSSSTTFTLSSSTSQIKKDSNHHLSDTHVVVDGSPSGGKTLLSRRARAASGASRDLSVSPSAGSGNWTDTGRLRHPSGSDSALRRCIRSTVSTSTTDISDSCVGQILVPSLERQTSIKQRMDVDGLALTCDPRQELLAQLLHSKEQRIVELEQLLARASEMIRRGRHLQQSPQPTGMEDLLMSDSEGGEPSSLGATSNPSLDSWEPLDEAEAKVVPWVPDHIVTHCAGCDALFWMGRWKHHCRNCGKVFCDECSNYRAPVPHAHLNKPERVCHRCHSTLLQLSPGASSDGRIPTLVADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9W9</accession>
    <name>A0ABM0K9W9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112434.2">
        <property type="nucleotide sequence ID" value="XM_005112377.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860625"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Zn-dependent metallo-hydrolase RNA specificity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cleavage and polyadenylation specificity factor 2 C-terminal" evidence="5">
        <location>
            <begin position="192"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005112434.2"/>
        </source>
    </evidence>
    <sequence length="336" mass="37718" checksum="2A5B7B9A5C774296" modified="2025-10-08" version="1">MEDSDESDAENDSEGLYGQSSKGKHDLMIQNEGKSRTGFFKQAKKSYPMFHFVEEKIKSDEYGELINQKEYTINNEPSSKGEVKEEVEAKDQDDSLQDMTEVPTKCISSTVTLDINARVQFIDFEGRSDGKSMRKYLSQIKPKQLILVHGPDEATKSLGEYCQNTGFVEGSVFCPNIGDVIDATTERHIYQVRLRDQLVSSLSFARARDMELAWVDGQLDIPPVDSVEEDEEMPDDEAAKKRAESQLNTNPPTLESLPPNMVPPHMSVFINEPKLSDFKVVLINAGVTCEFASGVLVCNNLVAVRRDAAGKMKLEGTLCEDYFKIRNLLYSQYAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA03</accession>
    <name>A0ABM0KA03_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBA-like domain-containing protein 2-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UBALD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112495.1">
        <property type="nucleotide sequence ID" value="XM_005112438.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855693"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14343">
        <property type="entry name" value="UBA_F100B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039310">
        <property type="entry name" value="UBALD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31993:SF4">
        <property type="entry name" value="UBA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31993">
        <property type="entry name" value="UBA-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005112495.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="14870" checksum="3E1FFB637730FAF2" modified="2025-10-08" version="1">MDNLKQQVMINQFVLAAGCHAEQAKQFLQAAQWQFEAALSMFFQESSVPSMCRTCNRSHTNGNYPLCTPANTPATPPNFPDALAALAKLTTGDNSKVFGASPHPHSSHPFPSPSQQSQPGVAHSPNSMQMQIETNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAA5</accession>
    <name>A0ABM0KAA5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Leucine-rich repeat neuronal protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112705.2">
        <property type="nucleotide sequence ID" value="XM_005112648.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848636"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF12">
        <property type="entry name" value="KEKKON 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005112705.2"/>
        </source>
    </evidence>
    <sequence length="384" mass="40881" checksum="BF5FD9864E973820" modified="2025-10-08" version="1">MAIHSHRGDNSSLGGGGNACPGDVPATVRDLTLVQSSCGAALGYREMRRLTELVNLNLYMCGYTTISRTAFRYNANLTRLTIRDSSLTSIATTAFQGAAGITHLDLTNNQLTTNDLKDPSRPSSNPKLSPLVSLRTLTLDHNNIGLVRPGMLDGLSSLASFSVNHNGLLRFESGSLSGLTNLEAVSATSNSVRSLDKSVFAGLPSLKRVDFSGNSIASVDPDAFKDTALLEEFRLADNRITSFPGETLRRKEPAPLRSPVSLQQVDLSNNRITALVAGDMAAPPKHSNSNATDTDTDDDTVIIAAVTVSAVVCLLTALALVTVVATAKRTRVSPHVTTSDVTQGEEENPAENQNVYNKYKTPRPTTASGVQLTLGLPMNARFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAG0</accession>
    <name>A0ABM0KAG0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101846786</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112825.1">
        <property type="nucleotide sequence ID" value="XM_005112768.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846786"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045114591" evidence="2">
        <location>
            <begin position="30"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112825.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="57917" checksum="F4C16C3375649871" modified="2025-10-08" version="1">MALPQSSVGSSSVLFAFLIVSGFLNPANSEYCPNPTNEYKSTIIPFTVPVALSTSSSFTWWARSYNKDLVTCYTDNETCTKTTDFENIITGSFSTSPSSKRLQLDVSEVNRVYPFDMETEWRLFDASRQTIYSCYLIVYKKPSDVYCNKPLFSIDNSSLSLTCHTVGVYPQGLCQFYRRSSPEGAENPLDNTRVQYSHDIYNPSPGERYSTTCTQTVPLSSLEAGAITFTVNMYPGFTGSNTSYGERLSPPVGIRLAYPNVTITSCPVVIDMADNFKSDYIREGAWFTCQCNLEHPGNPTGTIVWLNSTGHTVSTENMLPMASDHVISHPVFTINGKMRDDKIVPGDNVTVTCSDTGVIGEHIDLLCINNRVSINQDDEDKIEFLSVRTADNGTVCVCKWTSTLGCLLQGTKSLTVTSDDRDSELTFAALGVLCRVLAVAVIIAVLVIRRRRNGYTRMDVPAAKEKTRTTHQYVNVNTDKAYLDRSSAGQVMRANVNLLLLNSSNTCQLVTSRSYDLMQLRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KB18</accession>
    <name>A0ABM0KB18_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113287.1">
        <property type="nucleotide sequence ID" value="XM_005113230.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862774"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF18">
        <property type="entry name" value="IPT_TIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113287.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26681" checksum="86F1B985C786A46C" modified="2025-10-08" version="1">MSQRSVSVQSGDDNHDVIHDDNHDDNHDVTLADLEEDELFMVLGPDEIREWETMMSHRKEQLLKNQEDFRRWLDAMTRRRMFAYSRIRKLEMASQDRRKFLLKMAHVIEHSKKLAGAPKDSGKNNNDDKNNNNSKSNNHNNNNDSNNNDSNNNTTTNNNKTADGVSDGSATTGKSDEDKEQTLRAQTRVAPSGSSEVPKPDTPMVVPVLQKTDDQNISVNSAGDEIDQTSQQNGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBD0</accession>
    <name>A0ABM0KBD0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113504.3">
        <property type="nucleotide sequence ID" value="XM_005113447.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860232"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113504.3"/>
        </source>
    </evidence>
    <sequence length="106" mass="12068" checksum="C7AE5EB9C9753447" modified="2025-10-08" version="1">MKKLHHKVNIVPLLAKADILTKQELKAMKDRIMQEIEDNKIHVYEFPDCDSDEDEDFKQQDRELKASIPFAVVGCNTVVEAGGKKIRGRAYPWGIVEGELSKKMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV11</accession>
    <name>A0ABM0ZV11_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101863493 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935020.1">
        <property type="nucleotide sequence ID" value="XM_013079566.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863493"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935020.1"/>
        </source>
    </evidence>
    <sequence length="982" mass="105629" checksum="AD423558CE2AF7FC" modified="2025-10-08" version="1">MVDPVSRRPYPPSYGTDTTGSVSGPSCTFTIQASELGAGTHRLSVNMYPQFDGSGVAYGNISTVSPDVTFCYPVPEIVNCPSGAKVSGDHIMSGSTATCKCRQKTEGFPAGTVVLSQGGSTLGSGTVASGTVINPGNNNNDQTLTCRSESSLGQAGPSVSKIVKFAYGPSSATLTFSQTNPSSLCQGPSLSVVSTCTVDPRTVNPQPLYKISVNGARIDTSVQHTLQLQGGAHNIRFLVQNSLFPADLFTDVTETFIVRVPPPGPPEITVSQPSVPRTGETLVKENVTTRVQCVVRGGYPATSDVRLSCPSSQAGSSGVSSVVVTRSQGTQCSCTATHESGCYDKRSDITIKAAYGPESVMLERKKVRPEETGTYNLCPSATPDITMECSVGVVYPAASLTLTMTPTRTQTADACTGNNNKCSYNFVPTRGGNHEFRCDAVNNAFGDMRGDSPTVQVYVREPPKVSPKLTLNGKDFTGATADNSVVFVDGQENSIVCQVDGGFPKISPSDIYVQCDGENVTDGRVVFTPERNATYCTCRAQHPSGCYDLSTEVLVIVILQNKTQSDQSDDQMTIPVAVGAACAAFVLCCIITGAVYCYLKRKGCFQRLAKHKEEQSGMTRDNNGHQEENPYVDVDSVHISLQDIHTPVLIGRTMAEIITPDVTQTDGDGRRYNNVPVKSPVPTVGEKGHQEENPYVDVDSDHISSQDIHTPVITPDATQTDGDGRRYNNVLATSPVSRTRQKGHQEESPYVDVDSDHISSQDIHTPVLIGRTMAEIITPDATQTDGDGRRYNNVLVTSPVSTAGQKSRQEESPYVDVDSDHISSQDIHTPVLIGRTTVEIITPDATRTDGDGRRYNNVLVTSPVATSKKKERPKGNQYVDADMDLINAKNANTKILIGKTTAKTSTPDTRQAGYDDGRRYNNVSVTQPESGMGQKDQYMGFQPKAEYFNVDIDEDVDGHYSSPRNNAPVKGNYVNVQRHDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV58</accession>
    <name>A0ABM0ZV58_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein heavy chain 8, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106010994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935103.1">
        <property type="nucleotide sequence ID" value="XM_013079649.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106010994"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012935103.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32174" checksum="C27881E1202D7D82" modified="2025-10-08" version="1">MMLVDYKNLKESVPDMFVPLLQPTMFKIDSLMSPAFSTITWTSLELTAYFKELDKAFSDIKLLMKTVCDIKYMRVDAKLHQISETLLCFLPGEPLTVDDFLQKTRDTTCSVADKLNKSAHMVCDTVLELLRIFVNQAFLEYRTLEKVYADEQRIADPSVRKSMNASYTMTAIASLTNSTEPDRSPLPEDLMTREAYVTSCLALFDDFKNRMIDALLKSVRFSLSSLRRRFLANSSRSSSQGVGGAGEDDNVGKSGPFFQVDIELAIPAVVSASVLIVCGYTYCGSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVC4</accession>
    <name>A0ABM0ZVC4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101863310</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935248.1">
        <property type="nucleotide sequence ID" value="XM_013079794.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863310"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045586664" evidence="1">
        <location>
            <begin position="23"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935248.1"/>
        </source>
    </evidence>
    <sequence length="721" mass="80820" checksum="91A78DE490B8FF3F" modified="2025-10-08" version="1">MTRISWPSHIVLVLPAIVVVHCSWIANTPGCFDGCSDQVNCTVEQSHSCNRNVSDSLDFGGKVSSLNYTLTPPRDGKRRIKLTWRPPQTGSYKDVKGFSVWVMAVGHTVGKAAAHGSSGSLCYKLTPAVGWHGVHRDLTYTGGVSFYLNCMEIPAEIKTDLHLSVHTEPMNANIPQERQIKIHIEPDREPKKVWRPQLKKWMDEENIMHLQIRNPLKEAFFYEVTVIRGNMTSKQTRVSHRNYSVSTKDDGRNLSSLPNAEGWPHFLIPGLEPGKQYMLYIWPKNKDGQRMQHYIMTNPFKLSAKESKIPAPQSGTGNTPVIIGCLVTAVGLVVVITCVLIKVCRGPCAGHLAFMDYFTSSNNNSSQRPRALVIFYKESENFLKAVENHLIFLQHYVDVVSIHEQHGGLCRCCPIAPKHTWIDREIKDRIIVIYMSPCIRELMGTTDLSQVPGAAKDHDDVCLYALQRLRTSVLQSTVALIRLVTFDCFDVTDSQVTITDFTVPGTTVNLPVPLEVAKPGSDGSWKLTNIDQLLLELRRYNDFPDSNVSSLDNWRVWKEVREAEKFISLCGKGTGSQFTRVDDMNGMNDDVPLSQFISQDNLDSDSVAFDCLDTSQSVNVFSDDIPLGRYDSKEHVESASVCVDSDDVSEDENTVGLTFSSKAYEPQYGQLYVEPPRLPQRPVFPPAINCYNSASTDSFYSDLNKVNLTSGWGEPPFRKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWX6</accession>
    <name>A0ABM0ZWX6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase XIAP-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936196.1">
        <property type="nucleotide sequence ID" value="XM_013080742.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011370"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012936196.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47427" checksum="867E85B7D8036C93" modified="2025-10-08" version="1">MASTSFMERLRTFHSPLPQNFVSSLSNTPVKFAEAGWERADNVSYASDELVCRSCSVKHSGWAGESPLAVHRTRSPNCPFLNTPPSIPTHFVGCSTNLSVVSEIDDTIIDEGAQEPQTIFSICSSCDTNNAETLKRKLFSKRSTNNNHSGAKYGRRQAIVHPFKPLTGGYPMLFESLRLTTYNSPSSAEAAKWSRDGFIMISNLRAQCVFCGLQLEFDVCVDIVGEHKEKSPECPFVCHFDVGNISSEEQRSIHEKERSKYFMDVSQSNDSNKYRIKYPEFEDSADRSGTFSLWPKLLKSVFPPNTMAEAGFYYTGHNDMVRCFSCGVELFDWVPGADPLTQHACASPVCYFMLHSKGQEFINESQQQEVSFITFCCSFLYFMSSGLELCVQEGLQKLPRWDLKIRGHRGNLLGHQGKNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYE5</accession>
    <name>A0ABM0ZYE5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101847649</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012937090.1">
        <property type="nucleotide sequence ID" value="XM_013081636.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847649"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0420">Kringle</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045745783" description="protein-tyrosine-phosphatase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="12">
        <location>
            <begin position="80"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="513"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="687"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="798"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="979"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012937090.1"/>
        </source>
    </evidence>
    <sequence length="1064" mass="120182" checksum="BEBA09E18DD9F9AC" modified="2025-10-08" version="1">MAVNGRILTFLSIIQLILVSILADCDPGYFGWKCRLQCGRCLGGAVCEPVNGTCRQGCAPGYYGEHCLFESRCRYNDKAGTHYRGSMSTTAQGKTCVDWDLVPDKKDITFNKGDEPGNFCRNPLLGSGRQGELWCFTKTNTSEKGDVYTFSLCNVTHCECPPHLYGEGCKEQCHCSDLEDCDINGHCPTGCAPGWYGLRCNKKCERGLFGLRCQSKCSDKCLYNNCDAETGKCVDGCVEGFQGENCTIECMGKYGRNCQMPCGHCNDSPCHRETGHCKTGCVAGYSSSVAGVQLCDVECRHGFYGPSCVNKCGACRHRVTCDPVSGECPDGCQDGYKGKLCAKLCPSHMYGRDCLKKCGVCKDKQSCDPFTGRCSSGCEEGHTGFECIQRIKAKNNSASVALGAGLGVGAILIIVMLVFCIVYRKRTKKLKIPGNSVEVEDPLTRDESCQLLGDSRIGSEPPSFVREEDDNVRNEVQEPIYENVNNRKQTCPVAIPALYDYILKNKENGCEGFKKEFQELPMGLIAFCDIARKQENRVKNRYGNIFAYDHSRVILDPLPNEPNSDYVNANYMDGYSRPKAYIASQGPNKVMIRDFWRMVWQQRVSKIVMLTNLMEACKKKCEQYWPEDGSNKYGDITVLLVNATKYSDFTIRTFELTKEMEHNRIVKQFHFTTWSDHGAPTHPTTLLAFRRKVMNFKPDDTAPVLSHCSAGIGRTGTFIALNYLLEQAADKNEVDVLGCAQLLRANRVNMIQTLEQYVFVYEAVLEAIKTGNTTIARSSFHSTYEEMLSREGEEESPMEKQHDVLQLLSPTMEREECSAALMEENMAKNRFKNILPANRSRPFLYTPVEDCNDYINAVYLAGYTQKDKFIVTQMPLPTTVADFWRMLYDTSSDTIIMLNEFDRNDKSCALYWPEEYGYSEEHGPLSVELLSSSEADNDVTLRVFKLSHLDKGEERAIKQFMFKSWPDYQTTPHAVTPLLRLYRLVMEWLKQNSKGPVTIHCMNGASKSGVFVAMSLLLERLDLDYEVDVYQTVKQIRINRPQFIENIEQYKFLYQIVQEYMDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYG0</accession>
    <name>A0ABM0ZYG0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106011564</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937114.1">
        <property type="nucleotide sequence ID" value="XM_013081660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011564"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045901760" evidence="2">
        <location>
            <begin position="30"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937114.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="25810" checksum="14D1C4CD2B77C04C" modified="2025-10-08" version="1">MAKLNPSLIPAALFVFLHIIADCPEGVQCQDSFTHDLKIRYFSDVSLLCDHPGLNITDNPSTVNSISWVLPDGTTIDANSLLNDRKYVLSGPDDDVSLPTRDRPAFDAFNLTVLRVDDDVFGYYTCVIVRSVTPGSGDAPISVVRWGLNVDGADFSELLETYKENAIIGGAAAAGMLVLVGGGCLFYHCRYSSRKSDGDASDDDDDKEGVTNGVALSYNNDGFKSSDVEVINVEVTEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYZ6</accession>
    <name>A0ABM0ZYZ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Receptor-type tyrosine-protein phosphatase eta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937435.1">
        <property type="nucleotide sequence ID" value="XM_013081981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846131"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="284"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="432"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012937435.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="63286" checksum="E637B34FCACF1B66" modified="2025-10-08" version="1">MASNGQYNSSYVMSEIVIRPLFPEVSEYTATDFTAESSGSENTLSSFPVTVCLSCLKDLNTRQGSLTKVVLAVCKNKCGGSGAGRRKRAVDVDSLKTWAEAKKEGFTGMYRATPRGWHQDLLRTPGGQYVFTVGEDNSCSDTGTDFCNGPLPSREDFQVLLIVCNGAGCQDYLNDNSVFGTTPNSNVDNDDDNVVVIVLAVICSIMAVGIILGVIFFVCRHRRQKHHKETRPVQPDTLEETEMIKTRRPIPIRTFRRTLVQLHGDSNLLFRAEFEDLRKLSARLPHGNEPVDELPYVNVGGKLTRASETMDVFKANYIQGYNSVREYIAAQGPMPSTVPDFWRMVWEQKCKVIAMLSDQMKGWKGKGKSYWPKNLNESVEYGDVAVKMTQFSMINNKYTIRKFQISKGSDTRQLTHFCLQRWTDAKADLTVEDVVDFIQIVRQEATRTISWPFVVHCSAGVGHTGTFIALDYFTQYVDKHSLDENIDVFSYIMKMRENCPGMVQTETEYIFIFDVLMAVIQKKINEDQEWVYDNIGESEEDKNENLSREETSHYYSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1S4</accession>
    <name>A0ABM1A1S4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase-like protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939075.1">
        <property type="nucleotide sequence ID" value="XM_013083621.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012026"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF101">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012939075.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25072" checksum="7ADF6BFB4F154F7A" modified="2025-10-08" version="1">MANSCITEYKEQHVYTHEDGISSAECAKRYSEWAQAGKYEEHLSEEYYQGPIIAADTLAKLFPEPATRANVRVLDVAAGTGLVAERLKPRGFSNIDALEPSEGMLALALAKDLYVSSFTDLLGDQPTSIRTDTYDAAVISGGMGEGHIPCSGMKELLRVVKPGGYVVVVMRQQYLSIVPEYIDRLEPLMKKLEQQGKWEAVSRTVVPRYSFTNDGVVFVFKVKASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3H5</accession>
    <name>A0ABM1A3H5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Platelet-activating factor receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101864160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940078.1">
        <property type="nucleotide sequence ID" value="XM_013084624.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864160"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012940078.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38145" checksum="54FD7F6906886293" modified="2025-10-08" version="1">MDSGNHSHVTPSQSSEKGWVSDELLNIFVVFFLVAAAGPICFFGTIFNAINAIVFFKQGFQDTVNITLFFLAISDLGTLVNIFGMSICYNPWFVQADLPIHYHDLSYLTTGWLSLCFARISSWITAFVTFERCLCIALPLKVKTIITPRNTVIVILGIYVTMIVSVAPVYYAIGLGPKYFPQLNATKIGLVYISNGVSIENVSLSINAFSQLFSFFATITCTIILVHNLLLKSKWRQSSSSAVQQKSFSKRDAKVVKMIVFISSVFIACYLPSAVNFIATVIFDEYGVLGRYQNMFVLTWVIFLCLVATNSTVNIFVYYNMSSKFREILNDMLNIKRTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3U4</accession>
    <name>A0ABM1A3U4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ufm1-specific protease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C78 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940277.1">
        <property type="nucleotide sequence ID" value="XM_013084823.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858790"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF3">
        <property type="entry name" value="INACTIVE UFM1-SPECIFIC PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="28"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940277.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24509" checksum="1387EF52CD66F66D" modified="2025-10-08" version="1">MADSLKSDVPSEKYVSDVHLVLPGVVDDSLCSCSYTYYHYLCDGVDDRGWGCGYRTLQTLCSWVCRHPQLGPSLKKNYVPSIVEIQKALVSMQDKPESFIGSRQWIGSFEVSLCLDYFYEVPGKVIHVNSGSEISGVLPELHQHFQVVGAPIMMGGETDNSSKGIVGVRLEPPALLIVDPHCCEKDPDATSLQLSGFVKWLPIADLHLNSFYNLCLPKPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4G2</accession>
    <name>A0ABM1A4G2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106012378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940655.1">
        <property type="nucleotide sequence ID" value="XM_013085201.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012378"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012940655.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="16153" checksum="557DCE4A278586DD" modified="2025-10-08" version="1">MVDYDMDAPPYAPFFGVMGVTAAMSFCALGAAYGTAKSGTGISAMAVMKPELIMKSVIPVVMAGIIAIYGLVVAVVIIQDIPSTGYSLYKSFLHLGAGLSVGLSGMAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4H7</accession>
    <name>A0ABM1A4H7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho GTPase-activating protein 15 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101847274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940681.1">
        <property type="nucleotide sequence ID" value="XM_013085227.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847274"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13233">
        <property type="entry name" value="PH_ARHGAP9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="428"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="618"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="550"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012940681.1"/>
        </source>
    </evidence>
    <sequence length="808" mass="91273" checksum="89A45597D13424D8" modified="2025-10-08" version="1">MSEEVEDVVRVLYDYGYTDDSGQVTIKAGDLYRLVERTNNEWWQVYDPSDANGDCFFVPAQYVEVVSERSPLKTLSDLDKLLTFGESARDSPLTDYDDDREQTYANQVNRDNESDYVNSSSSHGEGETDGEYVNLEQYRNVARINPITVSACSDDVPGTSKNSSLPSPTAQELIQGTIPPPLPEEGTFVRVLVEGLPWDIYKEHSLQRLYYVNRETGERMWKPPRKDKPSSGEQPKPVVPITPPSLPTVSEKKGTEWSIPSEYEQVHDNGNLYFIHKSTQEKWKSLVDQVGRQYFHKMGSSDTRWNLPASAESSENPSDSAAPDLTTIQIRPRLRQKDSNWESQGHRLSTFGAQSMRAVKAMSTYGQLESSSSKASTLPANFSAPRPAPIANDRLPVARPVNLAPPSPSTLPQVPEGQQRSTLQLLTNEIFSGYLNKTKIAELGKKKSKKNWSQTFVVLQGSNLVFYKDQKSAPQKPGSPHGKPEGVISLQGAHVDFNPSKDITSKKNTILLYVSSGSSFLFQSDNEKTIREWFTRMKIVANDVSPAAETSPKEFDLKEDRKGMTRSVSADESPSLHSVDKNKNIVSIRAKLLNFISRRPAQEDLVKRGIIKDAVFGSLLHELCDREKVPVPKFVHQCVAAVESRGLTHDGLYRVSGNLAEIQRLRCAVDKDDSYNLYDRQWDVHVLTGALKLFFRELKEPVFPFHMYNRFFDAVRKEPRKEKMHAFKSAVSDLPRCNYFTLKELFQHLCKVIEVSHENRMQTQNVAIVFGPTLLWYNEDAASLAVQTVVQSKIVEFMLTEYSELFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4L6</accession>
    <name>A0ABM1A4L6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101855121</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940743.1">
        <property type="nucleotide sequence ID" value="XM_013085289.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855121"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026624">
        <property type="entry name" value="CECR6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940743.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="43989" checksum="3A59AEA08CC2501A" modified="2025-10-08" version="1">MTGMCFRLVGCCEKIQGAPAAVLCVVLFIIQAASMNFFLVQNLGTAHYVWIAADFVNAALLIICIIVAYSVLKAPEKQEVTGANGISCIAWILMSMSLAAKTIIILKKVTRIEEDDPGFMGPNALKTTIGLSGCVFLCFLMTQHDAPLGTERRQYIEELTGTVVFDILDTVDVLEVLFDKDKRATLSDGLEEFILAVATLNLLIPSLPLFTLAKTKYGMKKLSKKMVYLHRLLLVLIVNVPNLLVRMILWHGFSVGISPFCLKNIILICMTAFVFYENYKERYDDAKEREENELRGVNGKYRSNGDLPNNTDPDSYRPPTLDLTPNNNTSEKDEDGGGRGSSRRSRHSIDGRHQSYENVGSLDSNNSSRSRRSNYSEEEGDHLGFAMESRMVTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4Y0</accession>
    <name>A0ABM1A4Y0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="10">PARP</shortName>
            <ecNumber evidence="10">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101851060</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_012940910.1">
        <property type="nucleotide sequence ID" value="XM_013085456.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851060"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07997">
        <property type="entry name" value="WGR_PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="659"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="740"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="842"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="1408"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="14">
        <location>
            <begin position="2054"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="13">
        <location>
            <begin position="2181"/>
            <end position="2322"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="12">
        <location>
            <begin position="2332"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1476"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1849"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1877"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1486"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1509"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1531"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1849"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1879"/>
            <end position="1900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012940910.1"/>
        </source>
    </evidence>
    <sequence length="2543" mass="285892" checksum="6ABF8E1195076A29" modified="2025-10-08" version="1">MIPSFVKRLSSSLSFGSGSGSKSPGRGERGKQENGPSQGSSSSNNNGAVDYEEITALRRQSTHELPAGTGTETDAVRRKSSRSNAVASVREATKQLSRRSTKSISSVQSVRTEVTKTFSKSSSKLSVVPRLSRKETSKASLPSEAGGSSKKSSSLAKKGPLTKKASASQKNAAPVAPAVRKASVTKTDPRLWFPRGSILAVRTQNAQEFFLCRARKNIFNFTKEAPVNWLQTKRGSHLNENCYKTTYADSIDPASILMQVNMEKKSRLTHFLPPEEKLAICHLLKQVEDVEGGKISVDDVDDDVAEVVQIEEPPPKKPKIVKSASQKLREKAVKQALKKKTSGAKAEKPKQKRAAKKKGEAEPKRKKAVKKVNELELHPRPDIKVLDKDPLFETDANMPYVSKRANSRLVFRAIYLKDNKMLGKLLKDGNRMRDLLYKSLDNDDSPMKAAVEVGDAAVFKTLLHEYSGDKYESRLKDNDYETNMLEKLDNGSYNQRSLGIRFIRKLQASRGNREGNNAFLATEEVPRFSLSDLLLWGMSDALLKVWKNFKQKKGEEKSWTDAVSTRHFQFFLMAGDHKRAGKLVEEDLKLGCSGFNNLFRDVLLFEKEDLTNCSPSNVTQVNKRVFKLSPVHCAAVNPNVKYLEKLLSVVPDVHMTDTTGRRPIHFAACCSSTAPLELLLGWGGNPNDTDSQRNIPLHYAVKANRPDNVQLLFKHASANAGQDMLSGKYGVGGVNRPTKTSHTPLHLAVLRDKIEMAKVLLANGANVNAKLNVAMMQITPLMFAAQRGNLKMVRLLVEKGAVVEQKDRLGRTALIHACKNGATKVLSYFLHIGANGERGDHSDNTPLHYAAAFGWLFTVRFLLEAGVDPNASNMWKVTPVSVAYLKAQNGIVRELLNSDKVDINFPDDNGLTLVFRGCQSDLRQKDLEAQIKYLVEERGALCTTKDNDGRNPLHHLALNRTATDKNVKEAVSQSIKMAELLIKHGCKVTDVDEDGFTPAMLALGMNLNLPLAEFLLKSGSPVLAPPDGDPDRSVLHLLATNLWTKEGNPYQVQALCRKFKFDEEVDKMLQYVDSDGYTPLQLSVVSLKEAPCRVFSDLEEHRAAKLLQKKQWDNFHEYIKALIPASDLNAVVGKKFFAIDDMPKPDSTNWYEDIHHAGKSAAHLSLLLDDPTFDTKGNIVDRNSGYLFKMLVSAGTNVNVRDIGGRTVLNTVISKNRINVIPFLVKEAKCDVNLPDLEKTASGRSKVHPIIQASSNIAFPALLALAEFDKFDISASQKETGSSSLHILVKDHYRYLFQILQVLEKFAKRGYNFNAVDNRKRTIMHYAIRQNKGTLNESFELEVKLLQLGVDLSLQDDRGRTPFHYVFKKKNRGYRNYGSRSDAQDPAELAKLLGRNMTKEEINIKDNDGKTALHFAASNGAGICCMYLIMIGADFNVEDRDGNTPLALAILNKHDGCATTLIQSGSDLLSEVKVVSDSLKKKRKNQEKARKEKLGKASRPANKRRDSNDSEDDDDNDSDDDDGSDSGSDEKSDEEEEMSGEGDSDDGNLELGTKLMWRPLRDVQDKKDIEKIPIYQAAVTSDLNGVAMFVTEADSDRSGLTQLDAINIAINNCKYNTALRLVCTTTDLKVLKHVDDKGRNLLHVLALSCENNSKTSDGAINKIAEVLINSGVPVDVPDDYRCSPILYAVLNRHFNLADFLAEKSGGYKVKYTDGFGRGYLAAALWRSYSKGIDSNTWSFIERLIGKKLNVNQHFDLPVGEQWIRHNKTVDPNYWMSYRDHKITALILSIHIEDFDISHNFLQFGADPNLSDGNNLTPLMHAVVLNLKNHVKQLLNYEYDPKCPKNFTGLKEHETPAAEPKKGGKKLNPSVFNIVSVDNEASDDESEEEEEEMDVEDEDETSATSSAGEDFLPVKKTSQVKLDVKNKENQTALHLVARPKPEGTYDNEEIAFVLIKAGAKQTFDRQGQTPFDLALKSGAVKVACRLRSLYELPSKTMKVQYKRDFKVTDGVPPSKEKLTDFMEAADKVLQRFDSSQMVVEDKYVHEIDENCNVTNGELVKDEELDMYYDVLLTKVDVNRGEWGLYNFYQLQLVFQPGKKLYVLFTRWGRIEDSGQFQHTPFTDRETAVKEFMKIFREKTGNTWPEVKNFEQKPRKYRLVEDVARKAPPAQKDVDITLESSCKSVLPNQLHFVIKTMMNPKKMQLSMKATRGLSTDCLPFGQLNKERLMQGKRILEEIEKLVDQVEKYRKSHNRHDEVDPEEKAKYKEHLEKIDTLSNEYFHVVPQKNFSCEKLRPLDQRQRLMQQIQNLSNLLDYEVACKMLLGAMANRKVYNPVDYVYRCLDCKLELLSSDDPMMERILCYIWFSDKGNSTVQAIYKVAREGEDERFRAKEPQNRRFLWHGTSNSNLLSILRRGLLVAPAEARKTGWRFGKGIYFSDQFVKSKGYVARATTNFMLLCEVELGEVHTFDNKKSAEDQEDAMAKSDSVIAVGYSCAENWFFLRSGVKIPEKRGTTSNYFDYSSDNTEYIVKDPAQVCIRYLIQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A559</accession>
    <name>A0ABM1A559_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106012488</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106012488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941028.1">
        <property type="nucleotide sequence ID" value="XM_013085574.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012488"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012941028.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17256" checksum="B44C703AD079EFFA" modified="2025-10-08" version="1">MEAIVGTWNSRRDDYEYRPKKFVRSDAGFTKESLQHMVYFTMWFKVEKKSDDSYFNTMHLKPDDGETAVVNCGPYQLGVEVESYNTLTFQVDKVLVEEKDGKVVFRIRNTIGHTHIEYLTTLEVKDDVMYYVMDTRAGMVVRKLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5Y0</accession>
    <name>A0ABM1A5Y0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012598</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941459.1">
        <property type="nucleotide sequence ID" value="XM_013086005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012598"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941459.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="17705" checksum="256772931E63615F" modified="2025-10-08" version="1">QQLQQQHTWPPGLPAPPSQAAAIGQPQVFAPDARHAAVLGYRAAAAAAAAASSNTLASLMTRPPWLPQLDAPRHHHASVARHGLHFAALRPASSLELQCLQSAASSFSGVQQQQQQQQHGGGSGGKDRGGVVVAVVMLEVWCGGFDGGSVVMVVVVVVLVVVMWWWWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A696</accession>
    <name>A0ABM1A696_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101853718</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941625.1">
        <property type="nucleotide sequence ID" value="XM_013086171.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853718"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991:SF2">
        <property type="entry name" value="GH08893P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991">
        <property type="entry name" value="L 2 01289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045234694" evidence="2">
        <location>
            <begin position="27"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="153"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012941625.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36329" checksum="93FB750EA0A81AA7" modified="2025-10-08" version="1">MTTTMARLSVVAVVALLLLLSAPGRAQGEEGEDDELEEEKEKEVLDVDLHMWQQFYNENQKLLVLFVRSEKCEKCPAAVQSLAALLGQPELPTDLEVGKSADPSLAAKLEVSTYPTLVYLRDKSYVFYDGGFDLEELIDWLMHASQKVLQRLDDDSFEHLTQASSGATTGDWLVAFYSELCKKVLPSMETLGVRIRARTNVAKVNTAENPVLVDRFKINSCPQVILFKQGKMYRYELPKLDVASLRSFVDGFYRNAKAEAVPGQKSGFDHLTENIADSLKAQLEGENRTYILAGVVAACVLALGVLAMCCRSGLAGQEPKKKKKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7U8</accession>
    <name>A0ABM1A7U8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-amylase</fullName>
            <ecNumber evidence="5 13">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC106012870</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="5 13"/>
    <dbReference type="RefSeq" id="XP_012942518.1">
        <property type="nucleotide sequence ID" value="XM_013087064.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012870"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046613698" description="Alpha-amylase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="16">
        <location>
            <begin position="29"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="15">
        <location>
            <begin position="407"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012942518.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56130" checksum="9B48FF2B795BBAF0" modified="2025-10-08" version="1">MRTQTAFVLLLQLYGSLAYKDPHCADGRTGVVQLFEWRWDDIAAECKNFFGPYGFCAIQTSPATENRVISMPTRPWWERFQPVSYKIATRSGNETEFQNMVKTCADSGVSVYVKAVINHMTSGGSVGVGTGGSHFDGNTLDFPGVPYNISDFNDGHECPTLDGNIHDFNDVKQVRNCRLVNLLDLRLANPYVRGKIADYFNHLVELGVAGFQIDASKHMWPDDLKKILDQVKDVQMGGRPFVYHEVIDYGGEPIKGDEYLEIGRVTNFKFGRDMGMAFRKHEPLKNLQDFGEGTGLWASGDVVNFLDNPDEERGFMVSILTNSDPKLYKLATAFMLAHPYGIPRILSSYHFDVTSREHGPPQNADMSIKHVVVNGMNCSNGWICEHRWSEIYNMVAFRNMAAGKGMSNWWSNANYQIAFSRGDRAFIAFNLEDTDLDQTLTTGLAAGTYCDVISGYLENDKCTGKSVTVNADGTARIQVCAKCEQQMLAIHVGAKVGSPAKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8G7</accession>
    <name>A0ABM1A8G7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter G family member 20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012942844.1">
        <property type="nucleotide sequence ID" value="XM_013087390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860442"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012942844.1"/>
        </source>
    </evidence>
    <sequence length="661" mass="73370" checksum="98F2CC899EEA72D8" modified="2025-10-08" version="1">MPQYRDSCPVAVQCCDVRKHYGSGRSKQDVLCGLDMNVPYGAIYGLLGASGCGKTTLLKCIVGRTNVHGGYVSTLGRTPGTSGHLVPGRMVGYMPQETALFVRFTIGETLTFFGRLHGMSSDAIRERTDFLLSFLTLPEKSRLIGQLSGGQQRRVSLAAALLQEPELLILDEPTVGVDPVLREKIWEHLLDIAKSSLKTTIIITTHYIEEAALADRVGLMRGGRLLAEDKPSTLMSTYKLQNLEAVFLHLCHRDRLPNEDDEELLPSISLPSASDQESVKVQYKRPDSDSTGDSVLLLGGNKSTTYGSLKTPRDLTRGGCEGRIHLPIKTSYTYSGYEDCVVPGSPLSKSRRFRKMAMLPRARNLYALCVKNLTSMKRNIPILLFEFMVPVIQIVLFCVCIGREPRQIPVSIVNQDVDDLGGLFIGFLNNETMNKVAEPVYGTFEPSFTDFMASGLIVSATFFLATGLTTLSFVLERKEGLLERMYVAGVSALEIMMSHVLTQLTVMLGQILLMLGIALLGFQVGMVISACCRSEMASIQGTLGTMYPALLTSDIVFLFVYLISSFKTLFFFVYFMSSIQILFFLSYIIPGIIWPIEAMPNWMMKISYFLPMTYPTYAVRSIMGRGWSIQDSLVWMSYLISIAWIVIHSVVAGVLIHFQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8N0</accession>
    <name>A0ABM1A8N0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Hemicentin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101857206</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942941.1">
        <property type="nucleotide sequence ID" value="XM_013087487.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857206"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.155.10">
        <property type="entry name" value="Green fluorescent protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A914</accession>
    <name>A0ABM1A914_APLCA</name>
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        </submittedName>
    </protein>
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        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A971</accession>
    <name>A0ABM1A971_APLCA</name>
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        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_012943220.1">
        <property type="nucleotide sequence ID" value="XM_013087766.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854751"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="108"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="562"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012943220.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="88075" checksum="EAEED316E497D089" modified="2025-10-08" version="1">MDIRTSNEKEAWLKEKPKENGSGEQPNVRFKKGFWGGRTSLEKALIVLAVLLLIALITVVVVVVVDKNKEDETSHAAGHKSDGEVCLTTECVSAAARIHSYIDWTVQPCDDLYQFACGRWMREKVIPEDKSSLSTFGILRDEVEIVLKNLLEEEHKPTDLECTKKAKDLYKSCLNTDLINEKGDTALKELIVNELGGWPLITLGWDPMTFDLVNAIITHNKYNSYPLLSVYTGIDNKNSSQRILKMEQTDFGLPGQKYYLVARDDPMLIAYEDLIVGVAKLMGGETNEQVLREGAKEIVDFEIVLANISVPDEERRDANTLYNPMTLRDVHGNYSQAFDWRSYVFRVMTMPDIGITDISDDEVIINLSPPYYKRLTQVLQGTDRRTLANYVVWRFALQLLSTQGEPYQELIRVYRKAIYGISSEMARFRKCAAYTTSYVGLAVGRMFIKDNFDAEAKHMALEMIEGLQHSFNELVDDLDWMDKETKRVARIKNERIAPKIGYPEEITNNTYLEIYYSNYTYTPDDYFGNVLENRREGFKTTMRRLREPYDKEKWESPPSTVNAFYSSIRNQIMFPAGILQPPFFSQTYPKSLNYGGIGVVIGHEITHGFDDRGRQYDSDGNLVQWWSESAIEKFKGKAQCIVDQYGNFTVPEVDQNLNGVNTQGENIADNGGLKQAYRAYRNWVTEQGKEELPLPGLKFSHNQLFFINFAQLWCNLLREENALNRIRTGVHSPGRFRVIGSAQNSEDFNRAFDCPKNSYMNPENKCAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAE6</accession>
    <name>A0ABM1AAE6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3 12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101863468</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3 12"/>
    <dbReference type="RefSeq" id="XP_012943931.2">
        <property type="nucleotide sequence ID" value="XM_013088477.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863468"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="16">
        <location>
            <begin position="1973"/>
            <end position="2628"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="15">
        <location>
            <begin position="2749"/>
            <end position="3064"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="17">
        <location>
            <begin position="3105"/>
            <end position="3137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="648"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="821"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1803"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2004"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3049"/>
            <end position="3083"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2500"/>
            <end position="2527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="650"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="822"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2004"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="3049"/>
            <end position="3059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_012943931.2"/>
        </source>
    </evidence>
    <sequence length="3137" mass="351296" checksum="050A90FF6A53C818" modified="2025-10-08" version="1">MDGLSDVYSCLRALDASKVTERKNNAAKLQNLLSNSSVVETLDDNSDNHSPGSKTLTWNVVLKGVMKYVDLETSLLQTAKESQSAATLNNRDKKKLELAALFMFVIRTANERGPRLRLDWIMNWIRNALCDDYMREAFGLDFSNVLLKHVLRVRSYWLEISSKEWRDLLTLYCKLYEEGFLRQDLCAKVIKKLIQGSVLQGEVSPRKLFSFFSRVLQHFRDLQAASIVENVLSSLTTFCHAIAPACPAQLCEFAESHLDGLLYLWQNASTERVKEEMIDLLHLLVLVHHPAGAATEGEGAYAHDWTRWKVHLASLHESIVADINETGGRFRFSSGLKVSILKQRYIDLAVAVFKQLPGLIPASPEEVVAFTQVSQMGDRAGATPAKRQRLSVENKPLVELVKTCSNSLQAVPWLQILCALLRRHSESFSRNGLVNALGVLALLLHECKRGQLFTYVFECLSALTDASVPSDRETEKIWLSVWSSCSGTINSRQAEVEGYQDFGFQLMAGMLFQGLVRPGKEIWNLFLPNFSHPSPSSDGLLTALVHSQGLAENYCPNILGSSSMSKTQGAFPLRTLLVNWLLSQAMAENLEASARNLTPTRTAQLIYALALQDPLTVMKQFKEDNHQEEDISQIEKVHLRTAFGSLKSSAESRKSVGSRERRREESEDNNPQVDSVVEHVLKTLGTISRSLSELLEPSVETIEFLAWYSCTVVKLLFYVGPDGVPGTRLKQLVKVALEKCTGHFVNYVKKKGTCGLLPALKVFHEMFWFKGMTSMRMFWVVEVIRCDLSAAFVDLVVDMASGKLEKKREVRPSSHRNRYDRHRQFEWNEQREGSSHRGRENDLDFDLEPQRADLDPRNGASNTDLDFDERDASTNNNTTLPAAADDNHQFLGEDLLVEAQKVRLACVKLLCGLISYDRQLSESEEVPVRAEMDIGHLKEQLFALVEGLEPIKPVFVHTLITITEHVLTPVHVISGADVKALLKAFKLTAKNLAQDQRVCCAILQCLQKVIPHLAEKEEMPSSDIKLCRDMFFNFMTDFGSLASEGTVQLKLDLAKTHLELLKYDRACAWGTIKVPQSGDSGDSNGFSLCTVSQVFPDFLRDEIVEVSLFVAENVSSLFTKFAVDGTEMQEEKRTQNKAFDNLFLICNDFLNIRGSPSPVRRADMERNQQAACLYTLTSIICCSPICEKSCLLALCQVVADERVHLSRARKALDVISGNLGYSSSQDYLKCHLPYLVHNWLAEDMVNSPVAEFPYRLLGHTTLDEFVRANQDLIVSEILVTQRSLTDLESLLTSVQCDVRPSLRRALPVVLVHILPCFAVKVMEEERGTSSQPSVAARQSQRAAKCFDIVKERLSEQDINDCIFQNLGSIVVGLLSSLHISNDAASGALSSMIYPEPNPPFYNQRTIQATLDYMAQNFTVAEGGSGRGTSLITVLAKVPDGLQRVLLSLSTLMWCEHRPHEKARALHMYGLFVGMVLGELAQGLDGGWAAVVRDVVTRLLILLGSSLKTSLGQVVSPGFEEELILTALHILQRVCAETMKICPDEFANYAHQIVDTVVSAVGKSEAISKAAVTLLRAVLSSSPNNEELKASLRTLNPLPLNVPSLDELREGMDTLCGEQGLPLVLRLQNLLQAISFMSVVPSHGLVLRLNRLTRDLLTERREVLQMAVGSEGLCLLKKVVCALLSLTEWENQPLVAAAGSCLGAIGPVDLQTMTLPAGLGNSSSSIAMETFRNQEFEKYCWLIHKLDDCLLDKSLEVVRTAGEILQSVFSTASCVRFEAEYNKALRSKSFVFFYLHPFKRKTPKLDKMAPPPAPSKKDSLTPDTLDNQDLWLGVSGNSPLSHEEWIRNLTTALLRSGAVQDEMLAKIEPMCAFKTQFCEEALPYLVQDILLHGGEDFRRILSYHFTSFFRSHCAHKELGSSSAETRPLTLRKRSVQTMLRVVQFLRKQTRPALKRGVPQTEWQNNFWLDVDYLEVARAAQFCSAHFSAILFTEIWWERVREETSLPSTGSSSHTQSDSQQSALDPLTQVSSQGSGGQGAQRLLLEVYWSIGDPDGIYGCGAGRQADPSTRMQTYLHELQYERALTTQDMAVTHGTTSSPMSLLQTLHMCGMDYSLQGCLEGLQRLAEYPPPPVPPTSTTEQTSALSAAALYNCAEIEELQFQAAWELGRWDIRETLKQSRPESYHQSVYRALSSLRDGHLKVAEHAVNSARMSIMAQFECGAESCESLYPFLSQLQCLSHLDRAVQSCARVGDSSPEESTLGQQLSWSVSQRGRGAVNFKHERPLLQLLSSLGGALSNRGEGGGGRGGGEVLETTALWTLAVSARKAGQFQLAEKAVYELKRKASLIVHVGAEKLQLEEARLFWARAESNIALNIMQNLIKDMTQDVIAKNPPLYPEVLSTYGNWLAETKSETPSVIISDFLQKTVDTILEQSLSEDSSASSWTKTALEGFASLARFADEQYQLLADYMKSPMYETKRDLLRRSRSELEECHQFKGASKYLKVMEKTSAIDEQELEALENDCQRYLHQALENYLRCLKTGDLYDLKIFRVVSLWFDNCSSLEVNQMIEDYSASIQSHKFLPLYYQLAARMSTRPTDGGHFQAVLAKLMERVAQEHPHHALWVIMALAHAYKDDELLQKDKPSRMRKRKSTEEEEVAEEDRIQAAKILIEQLKGSERLGEIVKNMELLCVAYIQLANWSVEQYKTEKRPVPLLKQLMITKISRLDNVQMPSVELKVDPSSQYENLVSVKKFGADFRLAGGINLPKIITCTGSDGRERTQLVKGRDDLRQDAVMQQVFALVNQLLGRNSETHRRQLSIRTYKVVPLSQKCGLLEWCEGTKPLGEYLIGSPSAKGAHTRYRPKDWLFKDCRLHLSGAGNNPEKRYKAYQEICSHFKPVFRHFFMENFPEPSTWFERRLAYTRSVATNSIVGHILGLGDRHLMNILIDLQTAELVHIDLGIAFEQGRILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMQVMRGNSEALLTIVQVLLHDPLSHWSLSPQQALTIQRKREHVNADTMDMTSSGTVPSSGQVAGPSVVPRQDGANNNHQDAQERQNKLAERTLLRLRQKLAGQEERVPLSVSGQVTLLIQTASDPRNLSKLFAGWQPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAZ1</accession>
    <name>A0ABM1AAZ1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106013338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_012944244.1">
        <property type="nucleotide sequence ID" value="XM_013088790.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013338"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF527">
        <property type="entry name" value="PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="519"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012944244.1"/>
        </source>
    </evidence>
    <sequence length="724" mass="80118" checksum="8AC636199261EEB7" modified="2025-10-08" version="1">MKNFRHEHILSLLGVCLDNDPQFIIMELMEGGDLLSFLRSCRATSTTPARLLLPDLVKICVHVARGCCYLQDMHFVHRDLAARNCLVSTKSPADMTVKIGDFGLARDIYKHDYYRKEGEGLLPVRWMSPESLVDGFFTTQSDIWAFGVLMWEVITLGQQPYPARTNIDVLHFVRDGGKLERPEKCADEMYSLMRQCWSFNADNRPSFATLLEQLELFQEKCASMSPEEIAQLSPTVADVNIEACGSCSGEEEEEEEEEEEEENEEEAETRGLFTPNSRTITGGGSVRLTQAGKVKRLTDLLGDKEKQVIDLTKIGRKRTHSLDSDSKQSSQYEASPSHGREHYFPAAREYDHHGYLEPRGAKGGGRYLELVNYAPELRELRDPYGNPLTSHSGSAFTPVHMTRKGYHPSSVSYPLLAPEEEAEDAHCRDERDGAYGTVDYGTAASDICGGYRVDLSGSSLNYPGSSRLNNSGPYGLVSVEETPLYSQVRDARRHHSNDSSYLLYGDPMYSGHHPGEAAGGYPVSYSKPGGGPPRKFSDQDLYDSTAQYRRRPTSFGSSSSDHHYTSLECNNNNSNSNNNNNNSGGYAACNPYRGHNSYDEHGAVRRKSGGSTSSRRSSGKNHNYAKPGLGYQPPPTSEHSLSSQLTSNNSKVSPGGRDAWANSNLDDVFLDSEPAVECSPPAVRAGEFLNYQGQSHHNPRSRAQVFPENSTAVVGYESGQVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB83</accession>
    <name>A0ABM1AB83_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944380.1">
        <property type="nucleotide sequence ID" value="XM_013088926.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864668"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944380.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25923" checksum="2417D71FCBD60A33" modified="2025-10-08" version="1">MSTGNVHKHGVWPGDESREISPRSPAGDYDRSQLSWEDRRGSEGSGAGTPVDTASFIFNAWDTLLQETELDAQAHVDVASLLIKNVYSPLREVAAHKNRQADMLTCFRENFEAVLNETARQTGKAENDYHGSYQEFAKLPDKASEESTASSESIRGNLHNFHNDYILRIRATNRTVDEYNKALPQILEQTALTRPDPSMVHYKEVNEDQMDRQGHQRGSAKENTTESSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABU3</accession>
    <name>A0ABM1ABU3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate sulfotransferase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944711.1">
        <property type="nucleotide sequence ID" value="XM_013089257.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013451"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944711.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="44031" checksum="74D55DB01EED10EB" modified="2025-10-08" version="1">MKHKRRSKLSPAVLTVCGVLVYLSLTWTYLTSHYQTVYWISAFLFGVVSEPVMTTSCGLGDGQVDPGRTNKSKLILLSYMRSGSTYTGSLLALSPDVFYYFEPLLYTHDDDLEAIDVPIMSRLSFLHPFFPYPPKVLDFLHRLLQCQPTTHDLKYLLGAEYSESLTNYRDCTQKLRSIEDISSCLPLLANRCQSKAVTTTKTVRLKMEESEKSMRCDPGVKVIHLVRDPRPVFLSREAMHYYFDASTFCQRVARDARESLRLQKIYPDRMRTLRYEDLATAPVRTTKAIYEFAGIPWMPKLESRLRSETDSQKPYKIASRWRRKITHKQMKSVQDVCGEMMTIFGYNHFYSNDHLRDMQQPSWTKSYSEQFRKFHVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACX3</accession>
    <name>A0ABM1ACX3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ureidopropionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945296.1">
        <property type="nucleotide sequence ID" value="XM_013089842.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860296"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07587">
        <property type="entry name" value="ML_beta-AS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="78"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945296.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="43900" checksum="DD6F72A9C4ADA7AA" modified="2025-10-08" version="1">MAGQIESLEKILEEHIPPEKLKDVKRLLFGKELRALNIPKAAEQLALEKDFEVQGYGFDAAEESSRSPNIVRIGGIQNKIVLPTTAPILEQRDALFKRISDIISGAALCGVNVLCLQEAWTMPFAFCTREKQPWCEFAESAEDGASTKFLQELAKQYNMVIISPILERDEERGDVLWNTAVVISNTGQVLGKSRKNHIPRTGDFNESTYYMEGNTGHKVFQTQFGKIAINICYGRHHPLNWMMYATNGADIVFNPSATVDGLSEPMWPIEARNAAIANSYFTCGINRVGSESFKSEFTSGDGKPAHHDFGHFYGSSYIAGPDGSRTPGLSRVKDGLIFAEIDLNLCRQVRDKWGFRMTQRLDLYAEEMREAIRSDWKPDLVTDSSSRNRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADN3</accession>
    <name>A0ABM1ADN3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC101858150 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101858150</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112168.1">
        <property type="nucleotide sequence ID" value="XM_005112111.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012945684.1">
        <property type="nucleotide sequence ID" value="XM_013090230.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858150"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974:SF2">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005112168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945684.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="61663" checksum="EE5CAE309F925280" modified="2025-10-08" version="1">MGCGNSKSKAVDLSSGQRPLERPQAVPNSSNNSSGGNSSGQQNGDAYPKQATKPALSVQPQSRETVPPPQPEPSSKKELSEDEVKKRLERYMEIEKQVMEWEAKNLPKSLQAKKERLEEVKKTQAELENHYQAACSKVAKEKADVDKMQNPSVKAFFKDQKEFEEKMSKEQEEYLEAVSEQEVAKKQVDDIHDQTKALEKEVQEMSKEMNKLLALYDEQDQILDDIFSGHYGSELENQLEMEVDQLLDRKERIGVAKYKWINGRLLLYHACNQLAFAVRRWQMLGQVPGNNIPAKYQLATETRNNLIAAMANITSAKRYLNNIKFPYCETEEMNTLDKACRNIYIDMQTHERHMHAMQCYSITHRRCAALLQWFDNVIHNTIEKDLARAKAELSPKESALRQERLRLMKEKIGGDTSNLKISDKAFVEMHEDFDDDMLEPELMAISQPDKVEGGESGGLTPGDEGQAPAPTPLPLNELAPPPSQEDLFGNIEQLKKQHEQEQAQLEKMEETNKARMEQGLQEKLRRRRSKRRRMETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADZ2</accession>
    <name>A0ABM1ADZ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcium/calmodulin-dependent protein kinase type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945868.2">
        <property type="nucleotide sequence ID" value="XM_013090414.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852140"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945868.2"/>
        </source>
    </evidence>
    <sequence length="467" mass="51438" checksum="2D8CD619C0966DD0" modified="2025-10-08" version="1">MPLFGKKNEADKKLKESDIRRKYEFKDTLGTGAFSEVVLAENKLERGKYNAVKCINRRGLRGKEEALENEISVLRRLSHPNIVRLVDVFEDKTHVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQVLEAVDYMHDRGVVHRDLKPENLLFYSPADDSKIMISDFGLSKMEGSGIMATACGTPGYVGESVSTHNVIVSFVMSCCALTTDNLSCGCCTTGLKTSSRLALQSSSRLALQSSSRLALQSSSRLALQSSSRLALQSSSRLALQSSSRLALQSSSRLALKTSSRLALQSSSRLALQSSSRLALQSSSRLALQSSSRLALQSSRGTLCGYPPFYDENDAELFKQILKAQYEFDSPFWDEISDSAKDFIRHLMCKEPMSRFTCKGAIAHPWISGNAALDKNIHASVKAQMLKTFARMKWKQAYNATAVIRQMKKLVVNKEENSSNHASTATATPAAGNGSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFF5</accession>
    <name>A0ABM1AFF5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat and coiled-coil domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946619.1">
        <property type="nucleotide sequence ID" value="XM_013091165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863879"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946619.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10663" checksum="3C3F257A661A5954" modified="2025-10-08" version="1">MVTAHRKDESSTQMVAELTALVKEQKGRIAELSKSKHEQLGGYKGRIRELEESLEDARKANSQVDSLKQAKSKLQATVQAQESVIEGLKAERKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFK1</accession>
    <name>A0ABM1AFK1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">USP6 N-terminal-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946676.1">
        <property type="nucleotide sequence ID" value="XM_013091222.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847407"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF19">
        <property type="entry name" value="USP6 N-TERMINAL-LIKE PROTEIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946676.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="12195" checksum="01EA42193D7C309A" modified="2025-10-08" version="1">MSEIAALLLMYLNEEEAFWGLSQLFISPKHTMHGFFMHGFPKLLRFQEHHDTVLKKFLPKIRRHMERHEMYPTLYTIKWFLQCFLDRVSVTFFEKKKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFN2</accession>
    <name>A0ABM1AFN2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946718.2">
        <property type="nucleotide sequence ID" value="XM_013091264.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846481"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="202"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012946718.2"/>
        </source>
    </evidence>
    <sequence length="305" mass="34659" checksum="9E796281EF232C7D" modified="2025-10-08" version="1">MDVFYEPAKTPAVRAALSWDILCKEKCTLALILPLDFSEIFNIVQSQGDRNHYKPDRIVMGGQPLRNHLIADLLKIFKKVFLLYGSTEGSIMSQSTLTEAEEDFFSGKPVNVDNVRLVNKDQEKCKPKEVGTIHVRGPGVFKGYFNKLEETDKNTAKAFTADGWFNTEDNGFFDDQGNLFVLGREKDIIMYGSYIVYPGWLEKKIMAHPDVMDVVVVPVSDTVLFHNICACVRPAKDKTLDEENLRDFCEKIFLSSSEIECTPVPKYFMVLESFPEATTGKPDKKILMKMAEERFGQDAHYMSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VNQ0</accession>
    <name>A0ABM1VNQ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoporin p58/p45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824042.1">
        <property type="nucleotide sequence ID" value="XM_035968149.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850699"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15967">
        <property type="entry name" value="Nucleoporin_FG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824042.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="56662" checksum="7B3D591B28FCD3E2" modified="2025-10-08" version="1">MPGPFAFGAPGTATTQANSSFSFGAAKTTAPTLNLTNPAAATGTAATGTAAAGFNFGLGKXTASTSLFGTPASTASSGFGFGTTPTSSASTGFTLKVPAPTSTAATAGPGFAFGKTTTSSTTPGFGGVGLLGNAPAPAAAAAATTTASMGLGTGLFGTQPAARGGTSIFNSLPTSSAATGLGGVDPNTALKTGAGDGRGAASDGKTPKESFLPEPLTGTVDALQKFVKEEKSVREDIARMSSKPMLKVQEEVTALRQLLSVVSNGLQRNVCSVDKLKAEMTQKLKNAEMSQRTKEIPAGLPYENTAPTEYFHHLVQEFEERMVTYRQQIETLDSHLAALHQTSSHTPSEMLALLKKLHETFISLAAQLQAIHEQVKSQKDQYLTYHRVFHGDAKNIFHKPTPAPKVAKKTELSDLAGPNPFPGTTNAAARAMAIVQTMSQQPQGPPVTGLVLGNTSGFGASPFGGGIFGAAKPIQNFGATSLTGPSASIGGVGNLFSSTGLGSSPATGCFGTPATLGTSTTAALNLAGTNLNMSAANGKPQPFQLQKPPQGPKRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VNR6</accession>
    <name>A0ABM1VNR6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein kinase C</fullName>
            <ecNumber evidence="5">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC101849658</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="5"/>
    <dbReference type="RefSeq" id="XP_035824058.1">
        <property type="nucleotide sequence ID" value="XM_035968165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849658"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20795">
        <property type="entry name" value="C1_PKD_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01239">
        <property type="entry name" value="PH_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14082">
        <property type="entry name" value="STKc_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057764">
        <property type="entry name" value="Ubiquitin_PRKD1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25525">
        <property type="entry name" value="Ubiquitin_PRKD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="251"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="22">
        <location>
            <begin position="388"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="541"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008582"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_035824058.1"/>
        </source>
    </evidence>
    <sequence length="883" mass="100271" checksum="A33F8B335255E11A" modified="2025-10-08" version="1">MEPEISYSGRGRISFFMQIGLMRETIYVEPELSMPVLNDLACAFVDRKFPEHGFYNIVDKILLFRHDAADPNILRKLDNVADIKDGCLIEIVLSEQATMEDLQIRPHLLFVHSYKSPHFCDFCGEMLFGLVKQGLKCEGCGLNFHKRCAYKIPNNCAHDRLRRHSSSSVFFNLPVKADALSLPGSDNQVQYTISHLRNGSQVSLGQASCSSNLLSVPSQPTPPSPGGGRSKSWTGRPIWLEREYANRIKVPHTFVVHNYTRPTQCQWCKRLLKGIIRQGVQCKDCKFNCHRKCAPLVPNDCAGELPYDGGEALSESLDHAETDDVSDNFSDNFSDLTEVTDDGAPAVDDVEDNEELENKPPLSPIDSSNIPLMRVVQSVKHTKRAGSRTLKEGWMVHFTDKDKIRKRHFWRLDPKSIMFYMDETSTRYYKEIQLNSIINVEPAKPTRGHDYSRAPHVFEIVNDSLTYFVGEDPTYGQESNIVVSPESGIGLEQARHWEHAIRQALMPVTPQSSTGNVPADRNGNGESPKSGQAEISHLYQIIPEDVLGSGQFGIVYGGKHKRTNQEVAIKVIDKMRFPTKQEAQLKIEVEILKNLHHPGVVNLEQMFETNERIFVVMEKLKGDMLEMILSSPKGRLSERVTKFLISQILVALKHLHSKSIVHCDLKPENVLLSSETAFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLKKKGYNRSLDMWSVGVVVYVSLSGTFPFNEDEEISDQIQNASFMYPPNPWKDISQEGIDLISNLLQVKMRKRFTVDKSLNHLFLQDYQTWCDLRILEMQVGKRYLTHESDDERWEKYRQERNLKTWDEVGQKETSEPEFSIRDALPKSFLLLSLGIDHTSGPGDHDDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPA3</accession>
    <name>A0ABM1VPA3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC101858696</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101858696</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824245.1">
        <property type="nucleotide sequence ID" value="XM_035968352.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858696"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="55"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="634"/>
            <end position="682"/>
        </location>
    </feature>
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        <location>
            <begin position="867"/>
            <end position="918"/>
        </location>
    </feature>
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        <location>
            <begin position="1066"/>
            <end position="1093"/>
        </location>
    </feature>
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        <location>
            <begin position="1190"/>
            <end position="1210"/>
        </location>
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        <location>
            <begin position="1243"/>
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        <location>
            <begin position="1534"/>
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        </location>
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        <location>
            <begin position="2414"/>
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        <location>
            <begin position="2649"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="670"/>
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        </location>
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        <location>
            <begin position="870"/>
            <end position="904"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="1066"/>
            <end position="1075"/>
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    </feature>
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        <location>
            <begin position="1079"/>
            <end position="1091"/>
        </location>
    </feature>
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            <begin position="1534"/>
            <end position="1547"/>
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        <location>
            <begin position="1564"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1580"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2651"/>
            <end position="2692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035824245.1"/>
        </source>
    </evidence>
    <sequence length="2838" mass="311037" checksum="151B553747083123" modified="2025-10-08" version="1">MTSLVTGTPYNLTSVETSTLSPGNWTVDDRAGGKTVGQMVYLGYLWLALIIGLPGNALISSVYMSVKVKRTCDWFIFFLAVYDCAVCLFAVPLYLSLETGAWQESGTDLACKLEQFTIFTSQFSSVSILAIIAVDRYLKICHPTKRSLTARQARNIGLFAPGLSAAFAAPVLIWEGNVERRFCRVLDRYRDTLGVKIHLFATFTCYIFMFLVVTFCYSKVVIVVQRRIKRHKENALRRKHLMQIPAFIQAISNVNDPNGGGRMSSGRRKFSLFSLGGTRRLSALGPWVRARLSLPSDGDSAPRKLGLDADDVSAVASKESLEESKKKLDHALQCRSRDGSVTHETASLSGQRLTHSAVGVSLVKSVSSSLLSPCHEMSVLEPAISCCEFSPSSGFTTDEYNCFNSSYLAPLSQKKVSSTISAETVVSLESRATKKTADIEMRVLCGDKNRRVKVSSRDYDSDSEVVLPLLPPSGSQNEPGSFSKGGASLPLTVNVVSDVPSISLSAPCGEQERSVSSQSLLQADINNCTNQTFCQIDQTDIPSCWRVKDLVSYKEERNEPSCSQNCNAGQSIVCGNLTTDDTRSTDMINVSSEDDMCFQTLSSLQDKESICGQTMIGKGKHIESTLTHSCHPRAKNADEEQDLSDNEIKRDLGSTSESRFNSLPRYHGGESTQNTRGQPRRFSTQIDKAGPAETDALLGAELDVTLPCQLHSSPTFAPLTPSLFDIIDNDTSETKSTPAVTLPRGDREKEISPQCPLTLNYVIQDDGSFVLKGQAHGNHKECAQESICDSTIPAKRTKSVICRNGDVSHQLTPLITEVKSNRLHSRYCRHNFSKSKSAEVLTCAVKNSGITHRRENKKFRSLEKLRKENVSSQRNASCYPNAGETSSSESATVSPPLTSKTTATIDCPVGKDNNDTLDKDERVKGRRVPLLSNSLLICPCNPRMENSVERQGTGVDTLICEDANSKDRAMMIERHNEDGYCPDMHVTHDPLPSRTSKLLCNNSRPKSTVKGLPKSCASLLGKSDLLSLRLTDANGCCVCKKNERFDSSPIGKRSDHSCEYEVDKRNAHKSDDEGRVNISGETSGEQTGPHSKTTECKYGHRNILHSIQSNLPNSCVHKTPDKGSDNEVIISPSLFSSTQGGPVEQTSSYHSVIKDTSTSESSELSICQQQHNRPQHSHCSTLTPSVITNKAETEDERQMNKPSNTSRDKDSHLYRAHLTLRTARPTTPSGPESSELCREQNFQSAEPQRAAIDPTRKATVGGTHQMSGGVDERGNGGAKVGLKDVSSDFKNSVLEKCSGLLSGLLEQKHLCKSEGDVNGHPLFRPQSSDSARLYRVKVSKSCPLFCSYSWPSKSRHNNYVTAAGTDNSESHRQDLSHSIWEKGEEGSKQRQACSENQRLLKDSCNTSGHSLEQANRYHPLFFSQHDSSMGETDIREPLASENSDFGTNGVPAGSGRGCGSHANEVITARATNTSHNPSAITGFDLLSLRAEARQKKAEGSEQWCANNSVTSNISTVSVNPTDFNRKNYLTAEKISESDKPVHSDERGVSLNKSPSFQPADIASSLANPCSSLTHGDRELTNGSNPISSTDNSPCTKQGKHGLESPGAGKQCSHVLPSGNVVVSDNSPEITGYCPETVTVVEENNEPSSHQTDTTECAVITSVSRSLPDQTDRCAHDLLRNQCTRIPGAEMMSKIASPGVNSKRQLCDVEDNSIRTGLCDPDLTSKTSSRNFVNINPTHCGQNKQEPTCTTSADTSPLLPSFHQMLSSGLFQLNHSFTIQSTNRMLTDLYYPNRVGCLHLFSPQPGMCSFNMTGDTSKSPVCFTYLNAYLLCYSTFSPYPDIASTTRETKTKDCTTSHCSPPYASQSSDLFSELSSGSALGERPSQIAPPDLHPPPSWCRTSRCPPPKPSLKTHLLIGEAAKVVTTIFNDFQYTGIDTCSLPRKSGRPSNYPQWPHTTNLNLCVTQLFCINHTGSNFFSSRLHFLSQQSEAVTFSTSEPIVYSCSDSARFLLRPHSLPCRPGRFHPRSIYNCLDLRPITLLFSEDNKTIQFTAGSNSIFFNSLSTHSLHFISLSTNEPLAYWVSTGNTALLSIDATSVLKVSDEYRIRAINRPYVFTREEGIWQADKLAPLEGSRKNMSCKERGEIKSKADEQVKSVSDLHETNPTSGFRLPITFDPLAVCLECQTLESYMSRQGNRYDERRDRNSKRSAERTVPINALSVGTSGQLGGMSAASACFDPFVWDVDSRSLSLRPEDEELASTARQETVTGIPRDGGVNELTNGRHPIDISITSDEVCSAEATDFENGHTVSTVRQSKMEYMPKQLLKPEMTPGNSSRQFCPNICENVRVSAPSSKALAILGVDENFEPLPRGCPASMVKHDDKRQEGENTNFDARQAIHTTLLGCLPTFTIEHVNELEPGEPSQTSSTRSGERTKTNETCEMFVRSVFDAFLATSGFSFSSEPCLTSINDDDVDAEEDTRLLHSLSRGEADSRYRLTASSTNISQLDVGGQRTYTTNALILGTYLARMKRGAARKGRSKTGSVSPSWYSLNDLDQSEKHTSHRGSRLLYVNAVRRQINQALSLKNIRSFFRLDELAAAVKKGPRGVSKSRDTLGASRIDVIITRCESLVMDRQASQEMPPMRDRAATLDPSALETTSHGSSCDTSSTPHRSQATPTGQAAFTSSTADSPHSSLSRSDDQSLAYRSNATSLDLLSPASASIRSGSMCSGVSSMSRLSQLSAYTEHSRSDCEKITKRSAEREHNITKLLAVITAIFVISWSISWAVILTTALAPPTDTSTTDVRRSMAAQLFLVNHFSNIMVYTALSQSFREKLLQCLQILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSD5</accession>
    <name>A0ABM1VSD5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Major facilitator superfamily domain-containing protein 6-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC101856508</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097106.1">
        <property type="nucleotide sequence ID" value="XM_005097049.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825326.1">
        <property type="nucleotide sequence ID" value="XM_035969433.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825327.1">
        <property type="nucleotide sequence ID" value="XM_035969434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856508"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="405"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005097106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035825326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035825327.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="70451" checksum="16F0518253589F0B" modified="2025-10-08" version="1">MENDMSPAVEHHPQESSPDGLLVVGRKTPCIVNRKLLPVKGFYFTFMSAVGVLLPFIGLYMRHLGLSFHETGIIYGIMPFVSFFVRPAIGALADKLKRHKAVLILTTILTGIFYFVLVFVPSRPAPPSLSISTSIQCNTQDSFLQDCSDENSQGQCQVGLSYFNNVTHLHKGNKSRTCTFSCTVEDSSLPQFQACFTNETGPYNSLRCNGTLTHSSHLNFAVQDLKAVLASEIPRDRYHVDSVTCRDYDLKDVLFLKDSKHEARQILCERELSLQCKVSCSQNLDCSKDSSFDKTFFIFFFLFLLANILFAPLFPILDAAAYENLGEDGHRWGQQRLFGTVGFAIFAVTSAFIMDLKSDSKHLDFSVSFYLFLPLCAVSSIIGSWIHMSSDIVCGKFLKNIWNALKYMQVLAFLFLVTYFGILTGGIEAFLFVFLNGLGSSPLLFGFALLVNCSAEVPMLWMSGSIIKRFGYVCCLYLVLLCYAVRLLVYSVVGNPWLVLLVEPVHSVTFGLMYASASSYASVIAPPGMSATLQGLLGGLHFGIGKGIGSLITGFMFEAIGPRWTWGVFSIICVILLVFYVILNMFVFKSFQHPPAHRQGSGQEKREEHVKQEETLINRSSTPTPVEDGDPVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSH0</accession>
    <name>A0ABM1VSH0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable peptide chain release factor C12orf65 homolog, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101863893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825362.1">
        <property type="nucleotide sequence ID" value="XM_035969469.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863893"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="124"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035825362.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26611" checksum="BF257F558348746C" modified="2025-10-08" version="1">MMSFVSIPVIKMADFTAVAFRPLLCRNYTTNLAVPKTVCLYKVRRNVPSGCVYNPSCTFWRMNDKGTHSESSTPAVVSISRHFFSSWSNRDRVLKEIWIHKWPVLVQLSCCNYSVRRKDYKFPELRPEDLEENFVRGSGPGGQAVNQTANCVVLKHIPTGIVVKCQATRSLQENRKQAKKLLEEKLDLEMHGEDSYLGQLKQDKMEGKIEKKKRARAKLALKKAFKDREGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VT75</accession>
    <name>A0ABM1VT75_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Purine nucleoside phosphorylase LACC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825617.1">
        <property type="nucleotide sequence ID" value="XM_035969724.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849459"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="entry name" value="CNF1/YfiH-like putative cysteine hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616:SF2">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE LACC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YFIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="CNF1/YfiH-like putative cysteine hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035825617.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="44143" checksum="FB6847906E1CC670" modified="2025-10-08" version="1">MTESRPYTILDLLTDQSESTQRQLLASVEKKCNGETKSNTTVLSSALAESGPLSSYRTVVSQSVVDGIFKTKCRLDEAGTTDFLVVTTRIMKKYWEAVCFLMFSHVHNWSVLGVDVRDQSTIIVPPDLTQVETSIKNYLMSLDGSGKVEIIRSRIIPCDMFNAGFHTRQGGISQLPPLASMNMLHTIRKPDPLIVIAENRRRLAVAADFDLDLLNVARTEHGKKVWVMGRDPEPPLKYDGVITDVPGVVVAAPGADCCVILLADTRTGACGAVHAGWMGTVAMAARETLRAMVDNYGTDPRHVHAAIGPSVGGQCFDMPISDAQVITDLDPSLTWPSERKEGWVHTNLPGANAVILQNEGVPKENIDLTTALCTACNKNMFFSHRRDSIPFGNQLGFISCRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTW3</accession>
    <name>A0ABM1VTW3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Membrane-associated protein Hem isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC101852476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEM-1/HEM-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825855.1">
        <property type="nucleotide sequence ID" value="XM_035969962.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825857.1">
        <property type="nucleotide sequence ID" value="XM_035969964.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825858.1">
        <property type="nucleotide sequence ID" value="XM_035969965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852476"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019137">
        <property type="entry name" value="Nck-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093:SF10">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN HEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09735">
        <property type="entry name" value="Nckap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035825855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035825857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035825858.1"/>
        </source>
    </evidence>
    <sequence length="1147" mass="131958" checksum="3F504CA74EC662F2" modified="2025-10-08" version="1">MARPIMPAQQKLAEKLTILNDRGLGMLTRIYNIKKMLGSPENKPGLLSDKNLQPAIDKVLLKKFPLYDNKASQLGVVNQNKNEIIKSLSLYYFTFVDILMLKDHVVDLVTTIDACQAQMDITLNYDLTKSYLDLIVTYVSIMILLSKVDDRKTVLALYNSAHEFLHGRGDQSYHRLGQMFLDYDPPMKKLAEEFVPHSRSLMPALMSLHKVYARRNLPADMLRNNQVLAVLSEPAKMAAVPETDTVQCDYLSLDSMERWIIFGLMLCYQSLGEPQAWDLWKHALQSSYIVTLCRNEVLHIHSYIIAYFETLKSQHMQHQHKRISEMKEFQLQALQNSPAMHRERRKFLRSALRDLTLVFTEEPGLLGPKAKYIFQGLSLARDEVLWLLRHVTNPPSKRHNVKMSPEDFYDRQLPELLFYMEELRGLVKKYNEVIQRYYVQYLSGYDAVHLSQLIQNLSLCPDDESTILSSFYNSIAALNVKQVEKNELFDFRGFRLDWFRLQAYTSVSKAGLELRNHHELARHMNAVVFHTKMVDFLDEMINETGDLSIYCFYTTLFEHQFKQCMEFLAQHRYSIIFPMICSHFMNATHSLCPEERHSIGTTSVQYAHWFLREMSEEVNQVITSICEEQCMLNYKLLPKHSAAIIQSQRQKPKDKQSKKIQEPEKPGVESIRKNRENFTRMDKLHMALTDLCYAINYCTVIQVWDHGFVPREFFLQHLENRFNKALVGMMMFNAETNEIAKPSELLNGVRAYMNVLQSIENYVHIDIVRVFNNVLPMQTQPADAQGEKTITHNYTHWYLEVLLMRVACNPGQIVYSPSRKAFVTVAQGDGPMLAAEEYADLTELRALAELIGPYGMKYMGERLMLNIATQVDEIKKLVVQNKETLIQLRSSFDKPEVMRELVRKLMTPYKNAPCDADVLLMRMTRIGILLAFRSLAQEALNDVLDQRIPFLIGSIKDIQHHVPNTKDSMLPVSLKQQVVNELASSAGERCSVDPTLCNALRTLKSEHAEDEYTIACLLFVFVAVSIPKLARMDLSVFKAALEGHMNNCHCLAKSINGLAGALFSLYGPGDTDLRLQEFLALASSSLLRLGFENDKDTVKNRDSIYVLLDQIVQESPFLTMDLLESCFPYALLRNAYHTVYKASAADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW03</accession>
    <name>A0ABM1VW03_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101851315</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826595.1">
        <property type="nucleotide sequence ID" value="XM_035970702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851315"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22109">
        <property type="entry name" value="F-box_FBXO41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057038">
        <property type="entry name" value="FBX41/ZN365_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052283">
        <property type="entry name" value="GenomicStab_NeuMorph_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15739:SF5">
        <property type="entry name" value="LD23158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15739">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23165">
        <property type="entry name" value="zf-C2H2_FBX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBX41/ZN365 C2H2-type zinc finger" evidence="6">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="1496"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="794"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="839"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="905"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1445"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="267"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="431"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="569"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="742"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="839"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1215"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1297"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1339"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1445"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035826595.1"/>
        </source>
    </evidence>
    <sequence length="1801" mass="203026" checksum="79FF11F208EFC3AF" modified="2025-10-08" version="1">MDSSIPFRCPKCGDNAQFATLSELRGHLEADHSYLSGKPRHRAVVSNLQGATNLGDSSSLMDLYNNESQRLEQIIQKHKENELNNRRKRNESLNGSRNDQDSFGQGARRIRNIDRANFRTYGHPASRTSKYKLNAARNQIPAERIVQRELRSSTPNDHELHGDDGEGRDRLRDTVEQALRKVLVETLQDDTVDDTKDVRIPQEMSPTVSRIIPTQEESGNDAHVTGTVKALSNEILLERASQRATADSLFSAQDVLSNVEFAAEKRLSQQQELINKLAQDLKEKEKKLVSVTEEMEDLRTQQTNNVEKLNSLQKQSDLEHENLQRELNQKKKELDSLNEKIEETKLIVMKGNHGNLHHNEQDNNGFNIEDDNNMKTVSITDNDDDYKKVNKSPAIFPDEVSEQSSLSSNLVNAQPHTKPQEQMPSKKEEELLEVRLKSQRLENDRQNLLQDMQALLQTAATDKKRLQDELVDQVDLVNKLNVDVEKYKKEQADLMEETSALYNQADVCLAKLRSTLVEREHQLKSATSLLDEAKVTQQKLIKEKDECFRLAQDRENLFRSMLESNSDQVKLMKDSLISSERENKELQDQLSALRSKLRRKDSEEDKVAENASRWRHRAAEKEQEQLELKDAIKKKEEKLKKYRRELERMTSFLNNTAEKEQEARAKLEIFISNLIDRAGRAEEELKKLKAAEARNAGKLVNSKGTMTETRVDLSGLPGAGLNTSPNPDPASLSVDPLKRLSHYNNPQPDFQPLQSSHWKSSHTHPSTAPELSQSNIIHETYNDKVERWNNESYAGRNGMQDARGLSVPHQHATYPDLDPSKTFSEKVDYPGSYQGSTFQSKYPCQSAPLHSTQSIPSRSQNGNDYPTLQQPFNSPGPPLFQNTLEVDRIYQNVLSQENGIRSYNDKVSLPSAMTEQPTAEERSSWQHGDSGPQLSFDEDGIIWDKDSHGKRRDKYNGERFKYKGGDSDIGSISAYEYKSDYDENFSDVMYNIEERSHDESEDADVLLSMPKRKGYGRITKANTQPAPLGEKVEKVLTSLGPKPVESAARKQYSSSHRTPNSQTKAKTQREQAFTKANDYSTTDTSRESSPLHKAREVQRRLERLSKKKPEQLKSPASDTSHGFEVSHLESNLSSSSYASLRNVRFKPTSTTPVVEEAIAPVKLDRKPQLDASISTLEEKEKQKPEYHQIVKKNSILERKPKVREESPASISVTESRTDSLTDKTSEQISSLPCDKDQDLPDGGGKARGSETPAGNGGTVYSGPYYLNSNDQPQNVGKESVSQAQVSPNLNIVGIVGGKDKPQLAEELPKKNQEISQGDSHREHPVSSADTPRAAGPQPDKVKAVDHQEITNKEQEKSLQKTDVDPDLKKYTEAELTPAKRLKTRVFSVHESLELTSSGEELPDESTNHDFEDVEKHSVDACTDTDLEVLASPGHVQRGLVVRKKVPVKRQKKQRKQRNAPPPRKTLLEMSMSSGTEDLDEEVIANRQILHKMRVALFRIFAYLDTKTLLVMAEVCKEWCKVSRHPALWKKITLSDGEMSSQELLMHGLRSRAMSADETPDSFAAATRGSLEQGLERVLSASQDTLTSLHIEDCDNVLTDKCLWLVSGYCRLLTRLTYRSRIDHASGQLMFALGGGCPGITSLFVQPLQPCIKTSTMNNRCLLQIAQFYRDLQEIGLGGKEFDMAGLLPLVQSCQHLRTMHFDHCLPITADLVTALTRAGLKNLKILIIHGTFVEAKALLTVQGNCRQLHRIHVAVKIEDCVEDPTRKKDKEAYKKMLKALEALRSKAGIANIFGLEAMPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXY8</accession>
    <name>A0ABM1VXY8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urea-proton symporter DUR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827281.1">
        <property type="nucleotide sequence ID" value="XM_035971388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857968"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045787139" evidence="3">
        <location>
            <begin position="36"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827281.1"/>
        </source>
    </evidence>
    <sequence length="690" mass="75755" checksum="9D5C8102632646E6" modified="2025-10-08" version="1">MASVKECGTVAGVNPRRFLLPLLLLMVGLFASATAQNTSQRSCPLTLKPPTTNIGVKPVLSTDETALLMILGFGGFSIILALVHNNIRKYVFHDEHNLDTTFDAGGNVSMSLTAVTVASQLFWPGDILHSATLTTKNGIAGPFWYAVGIMFNIFVFPILSVQFKTKAPGAKTYLQIIKARFGKRAHTIFCMFAILTNLVITIGVLLAGKATIQVRLIFHSFLTFRSWGAFLFGIIEIFVSSAVTYCDQASWQSRIAAKPVQGVWGFILAGFIWFSIPNVMATTTGMAYLALSSDNGTHLLSENQILEGQRNNLEPHHCVLCGKTRKGLAKSTTNAHGDHTSELCSCANATNCTQCTEDVARARDSTQYYLKQPYSCTTHGRFRDYMDFLFDFKNWCIVWVTLSMIPLGLIVFKSGINLNWIFYSGATVTIPCFPPVVLSIVWVKATGTGLIAGSLSGLVSGVVATMVAATQYPGGLNLFLDNTVRDYTILAGNGIGFLVSLTVCIVGSLLTHKIKSPADEEFEWMKMYDIDNPLQPWELLYREDMKGMEYEERPSFAQMEQAFRKAKLTAYIAGSASIFLFAFLIPGIMAAFPDMNLTRFGMWLNFTQTWAVVMAIIVVVLPPTEEIIRIVRQCRKNKTPSQGTLKNGCTMGGNQFNIVRSPSAPEAYELVVKDSTDVIGANSDVLPTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZQ6</accession>
    <name>A0ABM1VZQ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118478422</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827899.1">
        <property type="nucleotide sequence ID" value="XM_035972006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478422"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827899.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18406" checksum="AC9EEA4D179DC44F" modified="2025-10-08" version="1">MNVPTVDSCPDHPSAVLDPPQTSSQAQLLKMNSPVTETTTGLTFLNTSVYWCHANPTNVSRPNLVYWTGVYNGPAFWGHEDLETALKDLAKMEKFYIYPSRRGKRRSCNPNKHTQRHFKFAILLDVDDDNHIHFRKNPLSFSKWKRARAEMSTRSLQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W155</accession>
    <name>A0ABM1W155_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PiggyBac transposable element-derived protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118478596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828398.1">
        <property type="nucleotide sequence ID" value="XM_035972505.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478596"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="139"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828398.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="70738" checksum="5F848483E29B4898" modified="2025-10-08" version="1">MSDSTSRSGSTVFRQDSDSGQSAPDNASDISWLSWDGNNVQALESEESASPRSTTSSSDEQQPSTSVARRSKSSSTRTTTATAPRPSARPRARPQPIPATANTFNFDLFDAGDRYVNDWLPDFSQQPGLLVDTENFRCVDFFSLFFSPAVIDLLVTQTNSYAAHCLDPLPATNYYKKRWSDTYREEMQAFIGLQIAMGLNPKPSIDDYWRSFWLVDIHFKQVMSRHRYKLLSAFFHFSDAAQHVPRGQAGYKPLQKIHNFLDLSPSFLTAYYPHQQVSIDESMARFKGRCHFRQYMPDKPTKRGFKCFCLCDSVSYYCLRFVVYTGKDFSPLPDGKAFTNHLVETLLDGYLDKSHILFCDNFYSSQGLFRELQNRQTGAVGTVVETRKGFPEQLKKVHLPLRKGDDPVFAKAGDLVATAWHDTKRVCLLSTVHSNGVMHKRIRCSKTPGGFRAVQKPILAESYNSYMGGVDHFDQLHRNYHYPHRSYKWYMALYHYVKDMCLVNAHILYKADGGTDSVKDFRSSVIDALVKPYMGMRPGRPRAQPNPTAERLSAAQLGHFPAKFADAKHRPLCKVCSTIKKRAQTRFYCPQCNTALCVERDCFRIWHTAADVRQARQQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2E2</accession>
    <name>A0ABM1W2E2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101853740</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828835.1">
        <property type="nucleotide sequence ID" value="XM_035972942.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853740"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828835.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20285" checksum="7CD049B9B3AFF166" modified="2025-10-08" version="1">MLLKSSSLESIKLLDWEKEHGRIPDRAAVVFHFDWSKKFLQPQEYAGSKDIGNLFSFRHPAVSEAAGMWLADERNIKMIATDTLTPDPLGLTKRQITTLPIHVRYSKEKRLIVENLKDTGKLPPRGFRLFAVPYKFDGASGAPTRTFAITHDELGTGGASVLSASLFGVFLSVWTLYLLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2M1</accession>
    <name>A0ABM1W2M1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Striated muscle-specific serine/threonine-protein kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC118478788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828914.1">
        <property type="nucleotide sequence ID" value="XM_035973021.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828915.1">
        <property type="nucleotide sequence ID" value="XM_035973022.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828916.1">
        <property type="nucleotide sequence ID" value="XM_035973023.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478788"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828916.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="59768" checksum="9A02A1E704EDE226" modified="2025-10-08" version="1">MTLEGRGKYIRQSWQCADRRESPTPAFLEAGSRQLQGVVVEAQTCGPTGRTTATTTTAPTTMVFMPYGAEMKSSSSDGDISLTVQAPGLSSLPARTRDSGFGASISSENDAVPPATSDFSSSYENVTSFCSPPSPVEERRFVEPEGLCLAGSRGLQGNINIPQRPSFPNAPPVAPKPKKKPPVPPPKPPVPPPKPKPAVKKKPKMKSVNFKDDVDIVPAEPFLGMQTVLEELSCELKEGNENSFVYPEVELKSTSFVQAETCCQPPKPHEADACTLETAEEVETKFPNSFVATKRKRNASPFPRSLTSPGGLGGTPTSLRSSSPAPSAFSKPRGGVNSPKKEQDESEDGVTSFRTGATREGRPRAPVIGSERSPFVRPSPVQKSFARSSTCSDASSASSASSSSSVSASTPLLVKTQQMGSVDVSPCRAGVGGRGAGRGGGGGGRDSPMMPLSPSCCSVGSSSSAVSSSSSSSSGSLLVAPNFESGIVGCGVGHQAVPEVPGYEDVGSSSTWCEKCPQGKCQTVYLHLPGRFHSVVVVFVVAVVVAFVVVVVDCDAVVESCLCQIPCSLHFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W374</accession>
    <name>A0ABM1W374_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DENN domain-containing protein 2B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829117.1">
        <property type="nucleotide sequence ID" value="XM_035973224.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850524"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF0">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="827"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
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        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829117.1"/>
        </source>
    </evidence>
    <sequence length="1266" mass="140216" checksum="4AE1C0A0F25B0B84" modified="2025-10-08" version="1">MSSPNHEGSIRHLPPGKLSNIKKLFEEDSNGDKPSPPSRPPAPSCRPKSSQARPKVPPPQRPASQPQAAVAAQVAANVSQLRETGGTSNKGTASDKNLDVNRLTAAKDPRRLSPTISRRITALMDNRGAVKDEETNVSNSAISQPQSIPKASPIHGFPKPGHRRGQSYGDAAVVLDNPVYGGFESKTRADPVVSEPYAKVNKHRKNETDTKKVKFDSEEVQIHRREAVRKNSGERRKTVACISPEDENGGSSGSGVSVAGRTKLFDSPKGEKPALPVKSESVKRQFSMRTAKEFQQQQQQKPVARITKAPVQDENTNAGSNSGLEAIYDPPWDLSKNPLVDKVKKAKPPSSALLPPSSTPGSPAKSAAPIKPPLPSLPPPKKDSPVHRTFSNVESGNESGALRRSKAQGASNLSDSPSKSTPAPPPPKPPRTHAHDSYLKVKLSQNLDTSSSSDSGKEQLSNVKKVQVVEPDSKVSDTSEEVEYLSVKDRISKMQQQKAESPPLSSSPPVSSSSSKDQTVVLRHQHPPSRPPPPRRRPNSGGAPPPLPPAHHLKSRPVTQFSPAHGDGPIVIPVSPRRFQPQTRQMASRQLSHTPGFQYQQRQPNDKLPPAPDGERPLQRFPLRKSFSSECIHSSQGSSLNLDETEDMTTMMQSTYESQYEAVIDAEGYAVPNEFMKLPGRRRADSQFDEDEVSPGQFLTRLEGFEGPDASAHNSNSNNSPGWGFRTATQEQTLDKVNKRKMNMVKQKINQAYADLDIAVRGSALMAEEDDWLVVEHGGHKESTETGVEQSELKRRVEHCMSVRLKSSKSIKHSKEYLSAIYPQLFEYCLVVGLRPLVDSSGYEPYVIHKFPENQRNYKVGSHGKIYMSMQEVSSNLSVPSFCFPDAGIFKPGSATAVSESYSFVMTYSDGSRVYGYCRRVQPPDASLPEVTCIISPIDAFNMYNTLLNEIESRRRVSSDLAMEVIAASFGRPLPKPGRVCNIRTLDNNGDMETIFLTRSSDNRLENVNYESPLCYLGTDKLVKVFSAMLMERRVMLCSANLSVLTQTVHALAALMYPFQWQHVYIPLLPQEMLDVVCAPMPYILGVLSAFLPSVLKMEMEEVLIVDLDKKSIVRSYGDESTIIPRKLQRALKTAINMCKIDTDASNAQWLMIAEAFLRMFIEAIGHFGNHIRTQQDGNRIFQKEGFILEMVSKEMRQFLEWFTETQMFEVFICNHLEKADYGTNDLFVQRLAENKETKDYSRRHKGLGAKVKNFGKALKTKLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W490</accession>
    <name>A0ABM1W490_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endoplasmic reticulum membrane sensor NFE2L1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829483.1">
        <property type="nucleotide sequence ID" value="XM_035973590.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860383"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14698">
        <property type="entry name" value="bZIP_CNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF55">
        <property type="entry name" value="SEGMENTATION PROTEIN CAP'N'COLLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="762"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="679"/>
        </location>
    </feature>
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        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
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        <location>
            <begin position="862"/>
            <end position="899"/>
        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="642"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035829483.1"/>
        </source>
    </evidence>
    <sequence length="899" mass="98306" checksum="F5642FD6AD87B202" modified="2025-10-08" version="1">MIKEYFTDGLIGLAILLSLFRTDLTGINNIINYPEVQDIIIGQTAAYLPANFHSPHNSFNVFSNQKHIDFDNEAFSAWYQNIHNLPLFRERSQNEIEAFLVSASGQNIVTEQFQADPPASVDSETNDVPEISSPTLPLESANSYTTDVEVSSTASEEAATAAQNSTTESPPVVVDVSVFFKSPFPGCNLTKEDLDLIDVLWRQDVDLGVGKEVYDQSLRQELEKERELEVVKQQEKQKAQRLAREKEERQKHEQANKWLKQNFTRDGETGEWLRLQNGTVGNNGSVATAPLPVTPDSPTDQFMTLEAALDYISASVDPNLLRSLENPEQTANVVDSFGDDFGSSFVADASQHELQETQEQLQSVPQMVPQPESSQNFLEHQDSLEESWSGLVTYLNMAAANSSSGNGTTDGLMGGAASSNNNMATMVAASSPLQDQMNVSSVPSEYDGLGQFDQSDYLLQNATMPSPTVDIANDFNGLTPMAELNASLTSQPSATAVDVDSDIDFDLGDLSFFNNLTTLQNTTSADLDLVQVNDMFMDMPSGEGAAVVSASTSTGVVDAPNTLSEGMDSLQMLEDEFNDSALSLSGSSPRDEFSDAFDGLEGATGGSELSGQHEDLSGPYSKVSRLSESSNDSGFAYQGGFSSSSSTPSSSSSVAGSPASSHHGNSSAASNDTEHDPNGSRALAQHQVAHNHTYNTPPGQLPREVKKYAQKEPARKGPQSRDQRRATEMKVPFTVDDIIEWPVDTFNEMLTKHKLSEAQLNLIRDIRRRGKNKVAAQNCRKRKVGVIVTLADEMLDLQKVRDRLVAERAQMERETRRMRDKFGQLYTHIFQSLRDERGEPYDPNLYSLQQSSDGNVFLVPRNLAANKNSSRTAPASSSSTKDAGSDTNNGSRKRKAFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q16968</accession>
    <name>Q16968_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17 19">Potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC100533422</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="1991" name="J. Neurosci." volume="11" first="918" last="927">
            <title>Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currents.</title>
            <authorList>
                <person name="Pfaffinger P.J."/>
                <person name="Furukawa Y."/>
                <person name="Zhao B."/>
                <person name="Dugan D."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="2010814"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="17">Central nervous system</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="1998" name="Nature" volume="392" first="945" last="948">
            <title>Crystal structure of the tetramerization domain of the Shaker potassium channel.</title>
            <authorList>
                <person name="Kreusch A."/>
                <person name="Pfaffinger P.J."/>
                <person name="Stevens C.F."/>
                <person name="Choe S."/>
            </authorList>
            <dbReference type="PubMed" id="9582078"/>
            <dbReference type="DOI" id="10.1038/31978"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 66-159</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="1999" name="Nat. Struct. Biol." volume="6" first="38" last="43">
            <title>Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels.</title>
            <authorList>
                <person name="Bixby K.A."/>
                <person name="Nanao M.H."/>
                <person name="Shen N.V."/>
                <person name="Kreusch A."/>
                <person name="Bellamy H."/>
                <person name="Pfaffinger P.J."/>
                <person name="Choe S."/>
            </authorList>
            <dbReference type="PubMed" id="9886290"/>
            <dbReference type="DOI" id="10.1038/4911"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.51 ANGSTROMS) OF 66-165</scope>
    </reference>
    <reference evidence="21 22 23" key="4">
        <citation type="journal article" date="2000" name="Nat. Struct. Biol." volume="7" first="403" last="407">
            <title>Voltage dependent activation of potassium channels is coupled to T1 domain structure.</title>
            <authorList>
                <person name="Cushman S.J."/>
                <person name="Nanao M.H."/>
                <person name="Jahng A.W."/>
                <person name="DeRubeis D."/>
                <person name="Choe S."/>
                <person name="Pfaffinger P.J."/>
            </authorList>
            <dbReference type="PubMed" id="10802739"/>
            <dbReference type="DOI" id="10.1038/75185"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 66-165</scope>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="M95914">
        <property type="protein sequence ID" value="AAA27756.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191634.1">
        <property type="nucleotide sequence ID" value="NM_001204705.1"/>
    </dbReference>
    <dbReference type="PDB" id="1A68">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A=66-159"/>
    </dbReference>
    <dbReference type="PDB" id="1EOD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.45 A"/>
        <property type="chains" value="A=66-165"/>
    </dbReference>
    <dbReference type="PDB" id="1EOE">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A=66-165"/>
    </dbReference>
    <dbReference type="PDB" id="1EOF">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.38 A"/>
        <property type="chains" value="A=66-165"/>
    </dbReference>
    <dbReference type="PDB" id="1T1D">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.51 A"/>
        <property type="chains" value="A=66-165"/>
    </dbReference>
    <dbReference type="PDBsum" id="1A68"/>
    <dbReference type="PDBsum" id="1EOD"/>
    <dbReference type="PDBsum" id="1EOE"/>
    <dbReference type="PDBsum" id="1EOF"/>
    <dbReference type="PDBsum" id="1T1D"/>
    <dbReference type="AlphaFoldDB" id="Q16968"/>
    <dbReference type="SMR" id="Q16968"/>
    <dbReference type="GeneID" id="100533422"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q16968"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000028">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000012">
        <property type="entry name" value="Potassium voltage-gated channel subfamily A member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20 21 22" id="KW-0002">3D-structure</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 17 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="16">
        <location>
            <begin position="66"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AAA27756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="NP_001191634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="1A68"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="1EOD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="1EOE"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PDB" id="1EOF"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PDB" id="1T1D"/>
        </source>
    </evidence>
    <sequence length="515" mass="58540" checksum="76F6579C4C4D91E4" modified="1996-11-01" version="1">MEVAMAGIEGNGGPAGYRDSYHSSQRPLLRSSNLPNSRSFPKLSEEDNANENGMGVPGSDYDCSCERVVINVSGLRFETQLKTLNQFPDTLLGNPQKRNRYYDPLRNEYFFDRNRPSFDAILYFYQSGGRLRRPVNVPLDVFSEEIKFYELGENAFERYREDEGFIKEEEKPLPQNEFQRRVWLLFEYPESSAAARLCAIFSVVIILLSIVIFCLETLPQFKHYRVVNSTANDSKESIEEDDIPKFNEPFFIIETCCIIWFTFELLVRFASCPEKLGFFKNIMNCIDIVAIIPYFITLGTVVADQSKSNNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADADQTHFKSIPDAFWWAVVTMTTVGYGDMRPIGVWGKLVGSLCAIAGVLTIALPVPVIVSNFNYFYHREGESTDKGQYKHVQSCPNYPEKKDSLDSECGSDIMEMEEGNHSTPLTEKVKENHAIKANNPGSDYGLETDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4C0U2</accession>
    <name>A0A0G4C0U2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 10">Vesicular glutamate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">VGLUT</name>
        <name evidence="10" type="synonym">LOC101848683</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2015" name="J. Neurosci." volume="35" first="9137" last="9149">
            <title>Functional Characterization of a Vesicular Glutamate Transporter in an Interneuron That Makes Excitatory and Inhibitory Synaptic Connections in a Molluscan Neural Circuit.</title>
            <authorList>
                <person name="Jing J."/>
                <person name="Alexeeva V."/>
                <person name="Chen S.A."/>
                <person name="Yu K."/>
                <person name="Due M.R."/>
                <person name="Tan L.N."/>
                <person name="Chen T.T."/>
                <person name="Liu D.D."/>
                <person name="Cropper E.C."/>
                <person name="Vilim F.S."/>
                <person name="Weiss K.R."/>
            </authorList>
            <dbReference type="PubMed" id="26085636"/>
            <dbReference type="DOI" id="10.1523/JNEUROSCI.0180-15.2015"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="8">Ganglion</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KR697562">
        <property type="protein sequence ID" value="AKN01760.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001297420.1">
        <property type="nucleotide sequence ID" value="NM_001310491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4C0U2"/>
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    <dbReference type="OrthoDB" id="2985014at2759"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBI1</accession>
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            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
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    <sequence length="253" mass="26370" checksum="99064EF827FD8249" modified="2025-10-08" version="1">MLLFNTILASCCLFLVRAQGGDTPDTTSTTAAPTESTTQAAAQASTSAVTASTAAATSMITTAAASTSTASAASSPSLPLPDSPGQPETTTTTAAPAPPVASTAAPTTEPPTTPSPTTATSVVAPTTQNIPPVSGQTSGSGSGLPSSQPTSGAGQSTPGGGGVYNPQTNYQTNPFGAYNQQYYNYNNGYYANPNTNFINGYGGGQYPNYNYNSNTNPYYNNYNNYNNYYNYQNYQRQQQLMYNMMFFGAMDFL</sequence>
</entry>
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            <begin position="1"/>
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            <begin position="20"/>
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        </location>
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            <begin position="41"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_005089895.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13689" checksum="1C7605ECD03561B9" modified="2025-10-08" version="1">MKTCMIVALFAMSLVVISAQVPEEAEQGPGPVPEEAQRGIPITKCTACKIVMSILEAAIDTLPKQDPEGNISEDLILSKLSEQCNILPKFLQRTCMTFVNADNVKLLLSLPSESVCRKIKLCRRS</sequence>
</entry>
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    <accession>A0ABM0JBK5</accession>
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        <submittedName>
            <fullName evidence="15">Potassium voltage-gated channel protein Shaker-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="15" type="primary">LOC101863226</name>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
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    </dbReference>
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        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
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        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="74"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005089913.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50599" checksum="A0AF9EFEF9FE91BD" modified="2025-10-08" version="1">MAVVSLLNQAPYRRTYSSRERLNAAEALDGSDLWLHQSDHQRPGSSKARNRRRCVTREGELLPLRHTCQLSTCERITINVSGKYFETWRKTLEDHPDTLLGDPDKRSKYYDKHKDEYFFDRHRPTFDAIFEYYLYGGGLKRPRPVPDDIFLSELDFFEIERCVVEDYRRGEGYISENIVLPERGFKRRVWMMMEYPETSLCAYIIAIISVLITVASIALFCVETLEGLDSKHCVQGKSPNWVDPFFLVETICSAWFTFELIIRFLSCPSKVTFFKDFKNLVDVTAVVPYYVTLFNVLSTMTCESAKSSASLAFLRVFRLVRIFKLTKHSAGLQVLVLTFKASVEGLCLFLVALTVCILVFSSAVYFAEIGIEGSMIHSIPDGFWWAIITMTTVGYGEVVPVGPLGKLIGMMCAIAGVLTLAIPVPIITENFNKFYSHKTGRGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC17</accession>
    <name>A0ABM0JC17_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin and armadillo repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090203.1">
        <property type="nucleotide sequence ID" value="XM_005090146.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848712"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043379">
        <property type="entry name" value="ANKAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46464">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46464:SF1">
        <property type="entry name" value="ANKYRIN AND ARMADILLO REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="732"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="773"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="814"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1333"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1398"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1347"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005090203.1"/>
        </source>
    </evidence>
    <sequence length="1430" mass="159087" checksum="82D9EEBEE5410BCA" modified="2025-10-08" version="1">MASPLDETSQMGTLIREAASYFDNLERYDSQELLAFSMAHWMLSTDVFRLPTDQPQGLISNISPKDDAAIILFPVDDKSPPLCYREVHNIIRELTIGMYVMHQTPLISLEANYDLATVCNIPPAYQDTRIGQLLIAVDYMMKALWHGAYFPKDKRTKFSERWRTNLDVNASGKPETKKPLLTEFLSAGLLDITKDPDFGNIYDEMPAEIAGDAEMAEERRFFMSHVDSLSMKLTFCQDKAESYKNMYIVQADYEVSSIVSLLDNQIDHTGYERLKTRLQMHEEIIKKHMAAKQETRRQLELLKLVSYLTPFLLGMRKRMKIPDINKLMSRYGVDECRTERELPPLIVGPEFKCKNFMFNDHYFHLHGGITMDLETDTMTEAPSEFIEGYSKIVEAAQVGFHGILHLDQAPKEHYNIPVVTVDGQEYYAIMLQLETFYGTNPQRPLWVRAYCEEMDKLKPKRLPIPDNNIHEQFKKNFGYKKAIKYKTPFNGLKICAQRGMVAMFSALARKMTGSRISKQDENGLSFLHHAAINNRPQIMVLLLMSAVDVNVRRNNILSTGPTALHMAARCGSLDGVTCLLANYANILATDQDGWAPIHHAAFFDHKPVIKLMVRKNTGLLELPTKNDQKSTPLLLAASSGGLSAVQCLIELGAMVRTKDGDGNDLVTLSALRFHTNVLEFMIQMDSPDAPVWDVLVDMLNDESMAKKDSAVKCLEVLSTSKPDHWKCILEANGVPALVSLLHLDNVEIQSVAASVLCNTSENYEIRLALSKAKAGPILIQLLSSEVDDIQSRAAIILSDIACIEGNQTLIADNGGIAPLVNLLDSELEDVLVNAVNAIRVLCNGNQCNQDAVAQCGGLEPLVEFLDVKSEDLQAGAAAALAAVTAKNIENQNAVIKDNAHKPLVELIRCSRSTTVQVKAASAVEALATNNAYSQKRFLELDAPKALIRLLKNVFVEVREQGACALWSLAGNTKTQQKYIAERITIPHIIQMLLEATEKLLYVGCMTAIALGYENMASQNKLASADAFQQLVRLLRSAKTSEKVLLMVIKVLGILCVGVAYRNNKVTQRKIAEEGGIPVLVHLLIHPPNDEIKVEVAISLGCVVLSNKENQEKLQEEPGFKFNILLALLKSKDQETQLRAGMALTIFAFNNTPQQFAIREAGGIKYSIFEKFVNSQDEFYQCYAAFQIVVLARVIVDRDQVPLTAQGITMLVDKIGSDKDKVVVLACSLLSSLAHTRAGLTDAMITTGALDLLVSKLDSENDLVRNGAAVTMGYLTFNKTAYRLLFSLCRNMPGLYNKLMDNIGDEPRINSEFINDFKRAMVIGLPTQCLEINGGRPVESGKPYSGRRPNTSHESLSRNNHNTHNRAVSAPMKLMRSGSGRQRIIPDLVVQTNVLQNKNFDSSQQTRPASTSTCVSSKTGSFKTKLSTYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDQ8</accession>
    <name>A0ABM0JDQ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101858541</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091319.1">
        <property type="nucleotide sequence ID" value="XM_005091262.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858541"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039212">
        <property type="entry name" value="RBFA_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725:SF0">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091319.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44451" checksum="C0AD85FE2D040A8D" modified="2025-10-08" version="1">MFCKLWRPSMVHPSATTVLNVFWRCLNTSRSNSNKSFAEHVEGKTMQKLINKKGAKTKRKWYQPHVAEPLEPLGKKMASVKKGENEAQRTRARQLGHVLYDKITQIVNTGELAQELQDKQVLITSVKMNPNFGGMNVYWDADRTDALEVEELLFANSGRLRSLLISYHVLGRIPAITFVKSKGKGSSVSRINELLEVADYGPDYKPTTWYKSAESTNRLTNNSVSKTEDGNGIKPSLSENQINVHVANREVAENVDSSNISTLRDSTLVRDLTCEYFSAEGLDFHCNVYSLPHEDLMKKVMAKKSKKHLNDEETVINSKDYSEYSEKLASLERIRMRSKAGKESTKVKQKRLERDVQDFLSMTTPRSVTDNDHIDDDFDEHDDVGDDNKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDR0</accession>
    <name>A0ABM0JDR0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM92A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091322.1">
        <property type="nucleotide sequence ID" value="XM_005091265.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859145"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009602">
        <property type="entry name" value="CBAR/FAM92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223:SF2">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06730">
        <property type="entry name" value="FAM92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091322.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36921" checksum="201D82560F7F6541" modified="2025-10-08" version="1">MSRSGAEIRRSESQQKVIQDRITAIEQHLGQLCDISSSYTRKTARLRDKGDMMAKQLMEYSEFEKWNPSLSNGMTKFAESMSAVQDYREAEVKRLEGKIITPLMNYGLLCKQTKNDLKAAFAARDREQTQKKKLEVTKAKTPGDRQKIAQLENELQKASIDASRSGKALEQQIDTFEAKKLKDMKKIMQDFVTVEMHFHAKALELYTQCFQTIERIDPDADLEEFRHQLRPNGSIRSDMARSASQASLESRQNSSGNTTPRGNTTPRKPPPAKPPTPTDTRKKIPAPPPINLQSDSEDDDDDDDEDDSDDDYDETETEPAASKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDY5</accession>
    <name>A0ABM0JDY5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101853055</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091475.1">
        <property type="nucleotide sequence ID" value="XM_005091418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853055"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091475.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21314" checksum="57BCB235F969A9A3" modified="2025-10-08" version="1">MAGFPEAKFQISPNGWINTDVFMSWLRDCFVPAVAHKRKPVVLFVDGHTSHTSNIEVIDLCIEEQILLYCLKSHASHIIQPLDQSLFGAMKQAWGEQCQKVMNQTGESISVRTFTAALKPVWDATTRPEVAFNGFAKSGIYPYNPERVVHADKLAPSRTFSTAPRAAATAPPPVAVTAPRAAATAPPPAAAPSPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE16</accession>
    <name>A0ABM0JE16_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Dynein heavy chain 10, axonemal isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101850776</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091552.1">
        <property type="nucleotide sequence ID" value="XM_005091495.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850776"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2042"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2321"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2662"/>
            <end position="2813"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="3010"/>
            <end position="3167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="64"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1435"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3477"/>
            <end position="3539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005091552.1"/>
        </source>
    </evidence>
    <sequence length="4686" mass="537964" checksum="8B7A8C46EFE9D2F7" modified="2025-10-08" version="1">[encoded data, 4686 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEB4</accession>
    <name>A0ABM0JEB4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101860720</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091760.1">
        <property type="nucleotide sequence ID" value="XM_005091703.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860720"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047118632" evidence="1">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005091760.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="23572" checksum="85E54025D386D913" modified="2025-10-08" version="1">MYVWSIIGVAVFYLAQNAVVSASIKEKEGGIVYQPRHLLRASVIARQKAVSIDEGKAPLPPGFKYIYVTNNGSLVNSSGAPGDTIEVSGSPKTQMRSVRMAASTVARMVKKMPQAIFRRISRDAGVGVFTAEEKIIIYPSFADLKNGDCGTNCTGDCEKTCTFDGRKYEDIGAAAGERAAIEEDSVMCGVTFNTFELIDVVSHEFGHTAMMYGMSDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFS3</accession>
    <name>A0ABM0JFS3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FK506-binding protein</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005092690.1">
        <property type="nucleotide sequence ID" value="XM_005092633.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853528"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036824">
        <property type="entry name" value="Nucleoplasmin_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69203">
        <property type="entry name" value="Nucleoplasmin-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="333"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005092690.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="45598" checksum="836402C377BD8F6E" modified="2025-10-08" version="1">MVVIRDMANMFWGVTIDAGKRYSQTVTQGFCLSMAALENKSGSNNEFVQVLLQHESSEYLLCTLQHGKLLQQPLNLNFAAGEQVSFSLNGSGIVHLTGFVVPEYEGEMDDESFSGSDEDIPDLVPAGSLQAGKRKAESPSKASKKLKLLTYDGGADGSDDEDDDDYVEGEEEEEEDFSDDFDDSFFDEDDSEEDDEDEEEDMGSAKKGKKAIETPQSAKQKAQLQKKTPQQTEKTPNASPKKTPKQNAKTPEPTETPSTPANGEDTSAKKKKKKKKKKNNEGDTSGNNSSMNESKSETPSSSSGQNSPKKRVVSGGTLVEDLKAGHGPEAKPGKMVSVYYVGTLAKNNKRFDSCTGGKPFRFRLNQGEVIKGWDKGVNGMKVGGKRRITVPASQGYGNMKQGPIPANSTLVFEVELKAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG18</accession>
    <name>A0ABM0JG18_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Growth factor receptor-bound protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092858.1">
        <property type="nucleotide sequence ID" value="XM_005092801.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853529"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09941">
        <property type="entry name" value="SH2_Grb2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11804">
        <property type="entry name" value="SH3_GRB2_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="60"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="157"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005092858.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24866" checksum="2D40C8201368707D" modified="2025-10-08" version="1">MEAVALHPFTATADDELSFKKGNTLKILSTFDDKNWYKAELNGKEGYVPHNYIEMCPHSWYVGKVSRSKAEEMLLQTEQPDGAFLVRNSESAPGEFSITVKFQNGVQHFKVLRDGGGKYFLWVVKFNSINELVNYHRTATVSRSHDIYFKDMVNHDLEVPKVRAIFDFDAQGSDELGFRKGDVIKVTQKVDSSWWRGELKGQEGMFPVTYVERILVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGL7</accession>
    <name>A0ABM0JGL7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101860150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005093236.1">
        <property type="nucleotide sequence ID" value="XM_005093179.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860150"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14545">
        <property type="entry name" value="PTPc-N1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051985">
        <property type="entry name" value="NR_tyrosine_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012265">
        <property type="entry name" value="Ptpn1/Ptpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000926">
        <property type="entry name" value="Tyr-Ptase_nr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="203"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005093236.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="54871" checksum="6220629335ECE576" modified="2025-10-08" version="1">MTSPTEREFAEFDSNSVWNEVYQRLKNEASLTTLGDEFSTKLARDPDNRRKNRYRDVSPYDHSRVVLSGDNNYINASLLKVPDASRQYILTQGPLEHTMCDFWQMTWEQNTKAVVMLNRVIEKGALKCAQYWPLGSNYGYEDEMYFPECGLRVTLITEQDFQHFSLRSLELEHMESGEKREVLHFHYTTWPDFGVPSSPDAFLHFLHSVRQTNSLAPDVGPAIVHCSAGIGRSGTFCLVDSCLVMVEKEGTMDNINVRESLIRMRSFRMGLIQTADQLRFSYLAIIQGAQAILKGSGLESLQTQNCSEGVPPPPPQRTSSLQPPAKPKTMPSALQLLSALDENEDPPALPPKKNSPLQRQSGFSGWDGEMATDDDLTDDDEDDEEFDKLIDRDEDKENIGDNVIAADSDSESDSEMQRAQVRQRIREQRKQETMQKIKEMKDKQRRSERWRPYKSFFTPSVYFGIAVLVGIAGVVVYRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIH5</accession>
    <name>A0ABM0JIH5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclear nucleic acid-binding protein C1D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101862788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094402.1">
        <property type="nucleotide sequence ID" value="XM_005094345.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862788"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094402.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18945" checksum="775E86694A2FC3FE" modified="2025-10-08" version="1">MTGSDDGIPRELKEKLAKFDTHLSELEGSLSHMFSLTRAEIVEKVDAIDVAKTDLVAAYAINSLFWMYLNVCGINPKEHAVKQELTRIQSYMARVKEVEEKKKEKAKAPKLDKKASRRFIMSALWLSAQKNEETGASTSASQEEGQETQAEQQNVKSQGKKRRRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIU8</accession>
    <name>A0ABM0JIU8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Protein FAM50 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC101863886</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094663.1">
        <property type="nucleotide sequence ID" value="XM_005094606.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094664.1">
        <property type="nucleotide sequence ID" value="XM_005094607.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824703.1">
        <property type="nucleotide sequence ID" value="XM_035968810.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863886"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="3">
        <location>
            <begin position="251"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005094664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035824703.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="47092" checksum="58910B4DDA01B30C" modified="2025-10-08" version="1">MAHYKGAAKEAGRAATLLKKRALEQEEAEAKKKKIEEELAIGSIHNKFATHYDAIEQSLKSSTIGLVTLDEMKARQENVIKERERQLANKHAEARLIELAKEDKKKRDQRKITMLSFDLDEEEEENDDDDDEEKFSKPSKFAKPSKFPKKSSSPTDSTEADTDQKSDVKTEVPDDDEVAAEDEDMEEKFSPFERQETSEEAKERKRKKRLGMNPDVDTSFLPDRDRDEEENKLREKLRQDWVATQERIKNEEISITYSYWDGSGHRRNARMKKGNTVQQFLQKCLENLRKEFNDLRPVSVDQLMYVKEDLIIPHHYSFYDFIVTKARGKSGPLFSFDVHDDIRMINDAKVEKSESHAGKVCLRSWYERNKHIFPASRWEPYDPEKSWDNYTISDKNAVKITVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIX9</accession>
    <name>A0ABM0JIX9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101858699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094727.1">
        <property type="nucleotide sequence ID" value="XM_005094670.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858699"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094727.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16726" checksum="9D1E85A056D64D00" modified="2025-10-08" version="1">MANTAESGASSATTTDQYAIYFELSPRLTWLVRIVNICTFFMVMISVILCFVQGHKNSSYYLIVCNLAISGFVCIVVNWWYKTGDLGSEKFWFILLICGVILWQCISSDIFIFKTELPAPTITTTPTPHTRNTTVFSWATMKSPITVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKW7</accession>
    <name>A0ABM0JKW7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101863806</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096114.2">
        <property type="nucleotide sequence ID" value="XM_005096057.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863806"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005096114.2"/>
        </source>
    </evidence>
    <sequence length="641" mass="70489" checksum="69923D9468C90EC8" modified="2025-10-08" version="1">MDCICVKKKHKRRRDPKKQRPISPHVSPAHSQPSTLGHVSDPRLPKVNSTGLWIGAPSLYAAGPSPAYYYGRPQGSHKHRPDVPIHIPRAVSEQRIPQARHPYVSARPVYGSHNNVYFTSVSQPPRIPMSVQRVPVHGAQRIYHSQQLAPVFEVPATTNMEIYDVYQFAGGSRSKLLETKHTPYYHNSEFTTHRRPERSKSDAQESRSRRPEVRKDSSRKYRSPSNDSRQNQMRSSSRENSIRSSVMGEQRVTRTVDSPERPRLVTTVSEQDMPSVHVNRAFSPDTGEIVRGSSTRTRSSTNATDRSVTASVSSGKTSQAPLANGSPGMVSATVISGNNSSRSGGSDRGLSTSATDSMKLLAKNKTDDQKTSVPGMVSVRVEKNGPVPATSSTQENKNADPSHYINKEDVYSIPHKAKVLAEDEEDDNPIITRMKEMVIEKSRSSSNPSSPRDVPPTMSNQIATLNSSHEKEGHVIQEITTVTKVTRSEVIESVVSDDKNSSSVNNKPPNSGTNVFDGFVLPELDELEKKSSNEDGIPRRVSVKEDKPLTNTESLSVNVSRDEVKDKSPSPDVSRVKEPLSPRLSSDGEGTHEDLSKAGKRIAESAFNFLDKYLSDDDGTESHIDSPPMSPGGLRAQGVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLD4</accession>
    <name>A0ABM0JLD4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Serine/threonine-protein kinase GRIK1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857181</name>
        <name evidence="6" type="synonym">LOC101857636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096432.1">
        <property type="nucleotide sequence ID" value="XM_005096375.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005096434.1">
        <property type="nucleotide sequence ID" value="XM_005096377.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857181"/>
    <dbReference type="GeneID" id="101857636"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005096432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005096434.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31383" checksum="AFF9BC93986AC65E" modified="2025-10-08" version="1">MATLTFPDVTVIRDGDFLNNFNLKFVRVLAKKKNSLVLEASMKNDDSIRKAIKKIPYLDSKGRHRGLEDSTEELTIMHNVQHPHLMKMDWVVTCDSFLAIYMPLCSQGSLDGLRQSLQWDQVERVFVQTACALRYLHDQRCVHGDVKPDNIFLDASGNAILGDFGCSQILPDGENTVSRWRGTLGYHGPEFFLGYKFDPFLMDAYALGATLWSLVFRLKPADLDLLDVVRNFSLPEMFREVLKGLLRGDPQKRLSVPGLLEFLSTREKLRGIMEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM64</accession>
    <name>A0ABM0JM64_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ELKS/Rab6-interacting/CAST family member 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005096948.1">
        <property type="nucleotide sequence ID" value="XM_005096891.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858624"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005096948.1"/>
        </source>
    </evidence>
    <sequence length="1017" mass="117788" checksum="72878A1C2504F05D" modified="2025-10-08" version="1">MPHNPKKKTTRRKSERRAIKDDTPEDLAKNESPESVLASSSCLRNDSLETALDSLELSTASSGAPEIIATETHTTIDQQGGKEEKKEREADSISLTASIVNEEEEIKNLDSEEDHELALPDGVEKIPEYTDVLKEDMYSFQIDEPELSRFPDLDRLFSEVIGSIEKNFRPSHVMQELRRFYDLLVQYRQNENNILEKLKSREEELKWLAHKTKRDPRLMKIIQLADGWRQERAEVEKRNVELICQVDLLHGDLRCMEQSTQIMQLNLERMQGELKENEENTSDLKQCQDTAMEREGRLNFLEYSLHHLQSEAKEKQKQHEEALQSLEQCEGELRSMITLETKFRQKEHENRNLVAERDLLKSQVAAHNSNAENSQKRLVVMDRTMTDLKCKLKAFKTNVSHMEVTVKKLNRHLANKRNQCSVLEEEKDRALHDVELLKMKVKEGEDEIKKINTKLKDRNILLHHKERKLKDIKEKLETVEERETVARKETVALNKTICNMERRETTAKREIDLMNTKIINADVRLRKEMTSLTLASSKADSLAKSLDVTLVQLKNCTSRNNSLRAEQLDADSRLKTFQALCDDHVRTIAQGEKNMASLIHNTKKLDQEVTKYRDTVFLLRGKNQVLTADAFSQLETTRILQKHLESTAKEGKSMMKAMDDQEKVLLSLRKAELKARSQLAQLEIENNAQKNTLERAVDQLGIQKTEASNLMMALRKVEEELRSSIVRETALCRDRDIFATRVIQGNIKLELQTIKLRHMEDVIMKGNKDYEDRITDITLLRREIRTLRRKLKLLDNTKYVNSELRTELTLTKRNLCLERNKRAAQDTFIPTRVHNVQKLKANFPSEYEQILKNQHLIRRLIAKSDYVVVQEHKIMSLQRSLMELKIILASRSPPGLAYTITTTKADNSAKDKQIKSLISELNMTRHDLEVAKLNSSRHVKSCGENRQITTVQITQAKRPRDVQYNPKWKCPPRVRGGGFLLYTPAKSRRSESVPSQNLGKTDKKSERKGEPKVQRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMB1</accession>
    <name>A0ABM0JMB1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein dispatched homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC118477129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dispatched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097030.2">
        <property type="nucleotide sequence ID" value="XM_005096973.2"/>
    </dbReference>
    <dbReference type="GeneID" id="118477129"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF3">
        <property type="entry name" value="PROTEIN DISPATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="255"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="689"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="886"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="933"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="980"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005097030.2"/>
        </source>
    </evidence>
    <sequence length="1081" mass="122591" checksum="AAB9B4D959E5919C" modified="2025-10-08" version="1">MFVSSDKGYSRVVVTSSRSRSLFNYEDLRSMCSMETTYFQETESYQDICIRREADGSCCPAWSLANYVALLRGRSSCKAITARDVTVVRRLLTRCAPFFHNFSLGPNCAGDVDAWFYSPQHPPRPCPGVPQRCKKYNAVYHILHFLADSTFLFPGTPSYMPSSAHSLPLGRSESYLKFSSMFLPVVAGSASVKIFQHLESMPRDFKGLRVVGAYFGVKYTLFERYLILDSVWLGVACGVIFVAMWLYTTSIFVTFMTFLSMFWAVEVAYFLYTFVFKIKFFPYMNMVTLIVIIGVGADDLYIYCKVWHLAKAEKNNGVLEKIVSDTLRHTALSMLVTSLTTATSFYANYISDISAIRCFSIFAGTCMLINFVLTITWLPASVMLYEKWCRCCVGLSNGDYRLCFCVCKFPYKIYYLITDWSRIFFEKLLPCLVIKFRYLWILLFGGLWLASILVIFYYPRLKLPNTHKFQVFASDHLLERYDFELSDMFDFERVKDGDDVPMFPITIVWGILASDNGDPLDPYNRGSLTFDPHFDLTTPNAQRWLLDFCAKLRRTDFYLQTPGLQLTDCFLEKFTHDYMRQPCITRDTECCNHTNYPFSESKMVSCLSNYIPLVRATPYVHYNSHSPGPRFDNGRISAFFVQFLSNHTFSHSYEAVQTFYRQVNQWVNEELLHAPMEMRRGWFISHLHFFDLQSSLAVGTPLALGVSLAVVAIVSFFTTLNVLISMYALLAVAATISVTLACLVLMEWELDVLESVVITVAVGLAIDLTLHYGVAFRLAPDVGREMRVINSIGRMGSPVSMAALTTMLAGAFMMPSTILAYRKFGVFLLLLVGLAWLYATFFFQSLLRIIGPHGGFGQFHWPASDCCAPASREHVDKTIYALSESTLSSSSTSTREHSHHGHHHGHHRHSRELEPLTDPDSKPHYHRDTDPRRHQRLHAHYHHHHHTQQSHHAHPHHQHHRARRKGEYTSVRTDIFAPEDSPSSTSRTRDSPAAIKTGGLSANSSCNDTSTLTVAADSLNSTPSPRSRELSSEFSDPGDQCTGRADHGALSDTDSVTSSVQRGTTQAQVEIFPHTLPLQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNS3</accession>
    <name>A0ABM0JNS3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Low molecular weight phosphotyrosine protein phosphatase</fullName>
            <shortName evidence="6">LMW-PTP</shortName>
            <shortName evidence="6">LMW-PTPase</shortName>
            <ecNumber evidence="6">3.1.3.2</ecNumber>
            <ecNumber evidence="6">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Low molecular weight cytosolic acid phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101864141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.1.3.48" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005098005.2">
        <property type="nucleotide sequence ID" value="XM_005097948.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864141"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="7">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005098005.2"/>
        </source>
    </evidence>
    <sequence length="161" mass="18128" checksum="EDAAF9DE2F5C6156" modified="2025-10-08" version="1">MASSQKHSVLFVCLGNICRSTMAEGVFEHLVEQNGTKGQWKIDSAGTGDWHIGCPPDSRTMKVLQKNGICNYKHSGRLITVEDFTSFDYIFGMDHQNIEDINELAPKNSTAKVLLLGSFDPQKELIIQDPYFTHSRNKNAFNEVYDQCLRCCTAFLDSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNZ2</accession>
    <name>A0ABM0JNZ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 26A1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101852321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098124.1">
        <property type="nucleotide sequence ID" value="XM_005098067.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852321"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF384">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005098124.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="57036" checksum="A868255625F12C10" modified="2025-10-08" version="1">MSTDVPDSTLSVTETKMGNATAVLTPVLGLMVPMVWCSVVTSLVLAVCTLAWRLRYSAMKDPASSLPLPPGSLGWPIVGETVQFVVQGAQFYVDHFKRYGPIYKTHLLGSPTARVSGAEHLHHLLNSEPQSLTMKLPGSVRHMMGKASLVTSKGDDHVRMKKIILEAFTTTRLSDYLPCVQQNTQRRIKSWCGQGRILGFQACEQLIVDLVLELVLGCRLENDRDGSVRKAVMTINNNLFCVPLNIPGGGFYKASKARAIISEFVLRRLADKGDKEHVSMLEVFLAAHHTEVGAAGKGAGQGLTAEEIVDNAISLMIAGTGTTSGALCCLLLLLGQHPEVVEEIREELNTAGLLSPDGPGELSYDVLQTLEFTQSVIKESLRLHTPAGGAFRKAEKPLEVAGYHIPKDWTVVYSIRDTHKSSKVFKDVSEFKPSRWQDAELSERLHRENPCHYMPFGRGPRACVGKALATMEMTVFLVELCRLATFELHNPDADMVFLPVTKPADDLPVTFYARKEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP63</accession>
    <name>A0ABM0JP63_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent protein deacetylase HST1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098272.2">
        <property type="nucleotide sequence ID" value="XM_005098215.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846135"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098272.2"/>
        </source>
    </evidence>
    <sequence length="311" mass="35041" checksum="0959DD352380F437" modified="2025-10-08" version="1">MSASTKRRRKNARSISSSSGSDSEDNNNNNSRLPSSRRHQSRNNDDVEVTPSNAKRQSFRILRKQHKPGFVLPTRDSVWNQIPDEASPNKSLKRITPKKTVNNFTKLYNNYNFDDYEDTSDDVSLASDNSNSDDSKQEKTRKHRIKNYHKRIKLQSSSSEEEKEEREKACVAGSSVTEEKLESSVRNIDAPFSQGETQPSEESDDDPVCSKTHNTSKNCSILRSDDDSEDDTKEKGGDDDDVKDKNKDDDGGYSKNDNDGNNDSDDSGDNGDGSQSSVTSDSSETNYESRSAMLNARKKRKQSALFRQLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPV0</accession>
    <name>A0ABM0JPV0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18">Polycystic kidney disease 2-like 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC101850803</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098718.2">
        <property type="nucleotide sequence ID" value="XM_005098661.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098719.2">
        <property type="nucleotide sequence ID" value="XM_005098662.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850803"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="606"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="683"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="811"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005098718.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005098719.2"/>
        </source>
    </evidence>
    <sequence length="883" mass="100510" checksum="B4B90440DE1980E4" modified="2025-10-08" version="1">MSNRPGSAQSRTAWDDGYGDGIRNDPDLGMDSEGYMAGQSRSAKSSSSQMVSSTTELKSKSSRSGGKGVLSFFTRGVRSLWATRQTEETKTNRELYVKTTLRELIIYIVFLVVLCVITFGMTSTTMYYYTKVMSDLFLDTANSENGGTFRTLTSVEDFWRYAKGPLVNGLYWETWYNNDTTPPGGLGYIYYENKLLGVPRLRQLKVHNDSCQVHEDFESFISECYDSYAESIEDTKSFGPYLTEPDDTSWKYFTEDQLHGSSHWGLLGVTYSGAGYYKDLNSTKAASVEIVNHLFDELWIRRGTRAVFVDFTVYNANINLFCVVRLLVEFPATGGAIPSWTFRTVKLIRYVTVGDYFILACEIIFCLFILYYMVEEALEIKKHKLSYFKSFWNILDILVIIISIVCVAFNVYRTLEVDAKLDELLADPTVYADFERLSYWETRFSNAIAIAVFMAWIKIFKYISFNKTMTQLSSTLGRCAKDLAGFFVMFLIIFLAFTQLGYLLFGTQVKDFSSFENSFFTLFRIILGDFDFHQLEQANRILGPIFFMLFVFFVFFVLINMFLAIINDTYSEVKSDMANTKNEFEIADYFKKGYMKMLDKLNFKRDKIVDIQKALQSADINQDKQLDFDEWRQDLKSRGYADGEIEAMFAKYDIDGDRVLDEEEQKRMQADLADQTAALNKEYEDLGGKTDRPGTGRRSSSRVSFNEGDSGDDSDDEDSGTKSSRTGRTSNGVSYEEFTVLSRRVDRMEHSIGSIVSKIDAVLVKLEAMEKAKLKRRETMGKILDSITESDGTSDEMKREQMEKLVREELERWDSETSVGANSGRGASPGGGSGHSGLRPRSRAESAQNGRLGKFAASLQNRLRGKPHDVHFVDIEMTGQRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQK4</accession>
    <name>A0ABM0JQK4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Uncharacterized protein LOC101848820</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101848820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005099223.1">
        <property type="nucleotide sequence ID" value="XM_005099166.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099226.1">
        <property type="nucleotide sequence ID" value="XM_005099169.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848820"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="811"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="866"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="898"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005099223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005099226.1"/>
        </source>
    </evidence>
    <sequence length="920" mass="100625" checksum="461E8C1B60970CB7" modified="2025-10-08" version="1">MEKRQDKQENGFVGRIEGGEKELQKWWSRNMNQQQQQQHIDGANERVDEGNRNRGVRRSDRKGENGNGGDKRRAGEGKDDGVSLGNQLLLSAASFGVEMIVTFQTIYGVLSLQYLGVPMYLVSVHGVVCGVSSLFIIPLIGRFTDCGNNTRFRKAVALFIGLGTLLTAVSLISASTVFKIQSDTASGVVQNGSIETTNGSHWSTVNTDLDRHQMGRNKSMPFEKGTPSNLTAFSSTRAVFLDRIEIESVDSSQNIGSTINHSVMSHSRDALPNVSDVLSGRANTLSPDKLNVLPDTLNFLSNMPKNLLYTSRILPGAYSVFKNTSSMSSNISFTHPDSSYITTTIVPVDDISSELSHLPVRVVLAILGFAFLALSFGVSMSPTRAFILEIVPSWQHSRILATATATSSVAGMCLSGMGLLNVPNLFGAVLHIDRMAGTLLFVCSFTGLFATLSFSITVCAGFWVKKTKTSAEMDSEDHVEQAGPEAPARRGCAGCCFSSCKRGNNSHEYKEIPTEEDVSIKTHEDNFGNTAESKSRIENGYDQNSIHTSSLGFTPSQYFPDYQGSRNDQQLEPSHTASEIGGEEYADCIYTPDDVDWEYTLSDSDITAQAISAPNDNLGDFYQRQIHNKNNIQIGNKAISHETKTSQGWRLSNSFDHFQNIVSNTSEETVPFVSVNDKEISPKNNANRAHTSSSISAGSNLFNKRLVILMIASFFSYGTLVAFKSFASNSLTIAVYKGDPKAAQGSEARENYERGLRMCSVGVFTYYVAYFILSFCNKKILDIAGPRALFIVANLLMTAACLVFVYTSHLAAYFCTMLFCGLHKSMSYTVPFLLATQYSQPGQSVSLECEESEDGKKGSHHNLGRVTAMVGFLLTAHYLVVSCAMGPLMHAVGTAWPPMYYCACVSCLAAMIMSCLYFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRM6</accession>
    <name>A0ABM0JRM6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell division cycle protein 27 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101863903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099956.1">
        <property type="nucleotide sequence ID" value="XM_005099899.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863903"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="706"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005099956.1"/>
        </source>
    </evidence>
    <sequence length="818" mass="92021" checksum="C0E0E8416E25297F" modified="2025-10-08" version="1">MLLQEPVQAAVWDALNNYSYGNAIFLAERLYAEVSNTECLHLLATCYYRAGKSYQAYMLLERNSCQTPQCKYLMARCCADIKKFAEAEKLLAGTILTKMKSHEDIEAEFGSMACYVFALLGFIYSKTERASKAAQCYRRSLKLNPLLWKSYEMLCSMGENVKPETVFQIPEQTAAGTVAPPCDPATLSEQTSEAVSANIVAASENLQLLSPRNICPNETPDNNSQNEPLLQEVRRAPRPNKQKPSLTPDPSQMRKATVPMKLFPNPVLASPSFGLLPVEQASFHVGSSTPSFISPVPSESQNLEVQAPIKSRPMTRRTQMGKSPVLNWSNTMKKMKEQESVNAPIRRSSRLFGNSNSNSSAVKENNKSQTPGTFSSTKGVNRRSKRTTKSQQELNEINKGELSVDTKYPLATELPIVDQIVQMQQQSLAGVLSLMTSIGKAYLSLSRYDCRNAIEHFSDLPEHQYYTGWVLCHVGRAYYELAEYQRSAKVFEEIRRLEPYHIEGLEFYSTVLWHLQKEVELSLLAQELTSMDRKSAEAWFVTGNCFSLQKEHDVAIKFFQRAIQVDHNFVYAYSLLAFEYIYLEEFDKALTCFRNAIRLDPRHYKAWYGVGMIYFKQEKFSLAEVHYRKALSINPQSSVLMCHIGVAQHAQQKTEQALHTLSTAIKSDPKNSLCMFHRASILFASDKHIEALEELETLKQIIPRESLVYFLMGKVHKKLGNTHLAMMNFSWANDLDPKGLNNQIKVAVDKRYVTEDDDPLARLEQDAALEGEGAGAVASAEADAGAEAEGDESANQDEANLFLMDAPNLQAIESDESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRY5</accession>
    <name>A0ABM0JRY5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tctex1 domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100157.1">
        <property type="nucleotide sequence ID" value="XM_005100100.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849848"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21459">
        <property type="entry name" value="DLC-like_TCTEX1D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF7">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005100157.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16989" checksum="96273256267B8132" modified="2025-10-08" version="1">MGEETAELSESKSVVPEAESDLSIPDTKETAQQNSYVIRPNFSQKFRPVNVKEMLHTVLGEKLTGKTYSSEDTTAWTKEISETIRDRLKDMGHDRYKFVVQVVIGEQRGEGVKMCCRCFWDSDTDNYAQDIFMNDSLFCVAAAYGVFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSY6</accession>
    <name>A0ABM0JSY6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101855798</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with DDI2. Interacts with TMEM35A/NACHO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the SWP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100783.1">
        <property type="nucleotide sequence ID" value="XM_005100726.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855798"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055375">
        <property type="entry name" value="Ribophorin_II_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055374">
        <property type="entry name" value="Ribophorin_II_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055373">
        <property type="entry name" value="Ribophorin_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05817">
        <property type="entry name" value="Ribophorin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23861">
        <property type="entry name" value="Ribophorin_II_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23860">
        <property type="entry name" value="Ribophorin_II_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044992482" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2" evidence="12">
        <location>
            <begin position="20"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II second" evidence="15">
        <location>
            <begin position="267"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II third" evidence="14">
        <location>
            <begin position="379"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="16">
        <location>
            <begin position="532"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005100783.1"/>
        </source>
    </evidence>
    <sequence length="633" mass="68285" checksum="60F2623F90E0EFCB" modified="2025-10-08" version="1">MAKVLSVVVILAIAVLGQALTPSSFLTTQDQRRLQSVFEAAAPYTDAQSAQYSVLGLKLLGAAIPNAQDACKGLSKIIDGTNVASIYHASAAAKAIGNCKVDVPEFKKTLSDAIKEDSSVQDIAFAFLAQKNLGLPADDAAVSKALLAALKNDDSPASHGYAFLAASQLKGDISKFVDNVEDVIAQADEVDDKYLQFEGGLFVTSLVVDGAYKLAEKTKKAPTIAQDKVIKFTNYFMSRKHVHQLKSAYYFLSVIKTLSTNNFHVPVAVSLASPVAVTQADPSVKVRVTDLMGGSLGEMTVTAESARHLGDDAVVLSKKQFSVAASDKSLFELNFLNAKPAKGFYKLTINVAPKKADARLIGTSGAEVEVKVTTKISVENVEIGVADKDQTTAARTTKLVHPNKAASVLEADYHQKVIMKFQLKDKSSGQLMNAHQTFVRLTNLKTKQEIIFVTESDNTFTNKFDLDVGASAKDFASVSGKYSMELIVGDAVIENPFSWLLADISLTFPEGGEAKADALSQYAKKPEIKHKFNVPEKRPPATVSMAFTALVLSPIAILLILWLRIGVNISNFPLSLSAVGFHVCLGAIFGLYYCYWTQLNMFVTLRYLGILAIPTFLFGNRLLSGLASKRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JT96</accession>
    <name>A0ABM0JT96_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease P protein subunit p20</fullName>
            <shortName evidence="4">RNaseP protein p20</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101858113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100960.1">
        <property type="nucleotide sequence ID" value="XM_005100903.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858113"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036572">
        <property type="entry name" value="RPP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005100960.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15928" checksum="2E813077B634E7D4" modified="2025-10-08" version="1">MQADTSIDEEEYTLRKRLPPRFPLRFNDVYVSEKTNFKAQEAKCQKLLDQGNEVIIHGLGKAVNRAINLALQLKNKGVGTVKLCVQTSTVDLTDDLIPETDGGEAKSSTRSNSAIHIRVYREMEDTDQKRSEAQAAQMSSGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTG7</accession>
    <name>A0ABM0JTG7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aurora/IPL1-related protein kinase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101848362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101085.1">
        <property type="nucleotide sequence ID" value="XM_005101028.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848362"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005101085.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38721" checksum="25AA598ECB91AE23" modified="2025-10-08" version="1">MSTMMNLPPEVYETYWVSATEALGLKEDTEIAKGGSCQVVVATDVNDPGKKKALKRLMFLEDERDYYKKHFYFCNEIRFLQNVQHPNIIQVDNALSCPGEFVIAMEYHPTDLFEAMTCLTDVEVTKYFTQVVDALLYLHDRHIVHGDVKLENVLIDTQGNAKLCDFGHAQLIPNKSSERWGGTPEYHAPEYIKGQPVEDVFKLESFSLGVFLCALSLYEYPVKGLDYLELLRGGESVPDIHRVCAERLLCPSPAERASISEIHQLLNDHRWPESHTNSDVIDESPAPVSAPKRRKCSHIKKECRNLHSRGKALMKKLKTKIVCWPENQLDISFPHFQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTS3</accession>
    <name>A0ABM0JTS3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862118 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101308.1">
        <property type="nucleotide sequence ID" value="XM_005101251.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862118"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101308.1"/>
        </source>
    </evidence>
    <sequence length="718" mass="78235" checksum="D87052C949DC238E" modified="2025-10-08" version="1">MDRSDLTFVPGDEASQEAVVPAIVQEGNYFIMDSEQLVSNPFQELQQEAAQEAQKKNSMTERLTSVKNNVCENHFQMEKSRLERQKTSKLKNLHDHSNKLRHEVKLLDLDRQRHQVEVKKRLDPEKDFTYDDGQIVNIERRLGANIASFYLDKKLKYPMRLRSVSDISVTPTVRKARQSLRLQDLKRSMDDANVAGRAERVQTAKSSSTALTAHSGLARRRGSRSAPLYAARSAAGVRAQSERVHNTMLPAIAGAAQPDSHEDGKPKTAPQSHQVKFAFENPLKILASSEESANLFARGHTYYPGLTRAVNTGLTDSSDEDDDPYPSEVIDLRALLFKDGETANAIPTTTNSINLSGFNIAQIHPAGSHHHHQHNDDLASLSHGSGPAPGLSLHHLAALRKAQGPPPKLTTDMMQVENEQISAKINKFLGDLAVPRRLRHGYDSSDEEEDDARAIQRPGDFFANVAAGGGGGSGGGGGGGGVKFFASTGVRTDDNPPNPFLSSNTKSTSTSDLLGVNNHNNNENKNVFAKNNSNNNTNNASTTTADRPTGVVARIKTTSGGSEGGDERGDEDEAGSKSGEKPPHKNKYGWQYIRGRPADGQLRGTYKSEDLVLQSLTGVPIRNALGTHVPLNSASRAMRHTATFKMHKIVERLIQERTKYERHQVEELKRQMATDEPGTPHTATGPGPGPGPGLGPSPSPAHPSRRVSRVSNLTVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUI0</accession>
    <name>A0ABM0JUI0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC101856816 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC101856816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101802.1">
        <property type="nucleotide sequence ID" value="XM_005101745.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005101803.1">
        <property type="nucleotide sequence ID" value="XM_005101746.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939946.1">
        <property type="nucleotide sequence ID" value="XM_013084492.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856816"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16338">
        <property type="entry name" value="CpcT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.590">
        <property type="entry name" value="CpcT/CpeT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010404">
        <property type="entry name" value="CpcT/CpeT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038672">
        <property type="entry name" value="CpcT/CpeT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06206">
        <property type="entry name" value="CpeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021111" evidence="1">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939946.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29403" checksum="51726F0FCA3327B5" modified="2025-10-08" version="1">MTVYNALLLFLCAGIMEPTLSWPWPAGSMMSSSPLLSEFASLFAGQYSNMEQYLEDQANNVTGQDKHFWLQFFYVPVDIPALAPAVTFYYELVVAGSSSPARQQVYAFTKESPCSVRQASYEIANSSRFSTRPAGLRALTSLSTSELSNRRECDAIWRKTGEDSFRSELATDRCNFTFFGKEVRPEGHRNLSCDGLTFVETFNQISDGAVVSGTSIRYDMQLVGQRYSPPFSVVPGCVQRPCRPKTATPGPSFTDIKQLLSQHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV34</accession>
    <name>A0ABM0JV34_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-related protein Rab-33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101851654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102208.1">
        <property type="nucleotide sequence ID" value="XM_005102151.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851654"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04115">
        <property type="entry name" value="Rab33B_Rab33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041822">
        <property type="entry name" value="Rab33A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005102208.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29483" checksum="E6A4BF3AAEA60B86" modified="2025-10-08" version="1">MDSELREIEHRDNQLKSPQTRAVSTDGNTDPAGLQNVRVIEKQAQKRIFKIIVIGDSNVGKTCLTYRFCSGKFPDKTEATIGVDFREKQLEVDGENLKLQLWDTAGQERFRKSMVQHYYRNVHAVIFVYDITKMSSFENMSQWIEECDRHNLNKNIPRILVGNKCDEVDKVAVNTNMAQKFADAHGMPLFETSAKDDDKANHVDAIFMTVSHKLKNAKPMMPVHMSSLSPHDSVNLRGSPQHRGLQSAVGVGAGDKSSDCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVI8</accession>
    <name>A0ABM0JVI8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger BED domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005102535.1">
        <property type="nucleotide sequence ID" value="XM_005102478.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864469"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1070">
        <property type="entry name" value="Zinc finger, BED domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005102535.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="62696" checksum="7AC6ACA15294CC78" modified="2025-10-08" version="1">MASSSASGSRSSVVWTLMERSFDRKKATCKVCRATFSHQGSTTTILKHLQRAHPTELEQARTEKDQEHRESSSAPATSSRLTQMSVLQSLEKSKPYDPHGQKKRALDTLLMEMIAADLQPFSIVEDRGFLRFVKGLDPKYSLPSRRTLTRSLLPQLYIDEQAKVMHLLMDTNFVCLTTDHWSSRRIQGFLTVTAHFVTSDWELQACVLDTVRIATSLTAQTIAGALTEVMDRWKITDKVFAVITDNAANMKLAVDLLGVRHGPCFAPLLNLVVSDALKSPQAGIEEVKKKVKIIVAHFKHSVKASDNLERLQRSAPGAAGPSSSSEPLRLIQEVDTRWNSTFYMFQRFLHLYQFVKAALLEEDKPEKFLTEEELNKVKEAITVLEPFELTTREMSSEKYPTASKIIPLVDNLEKIMRQTKGDLAAQLRSGILSRFAGAEERFLWAAATFIDSRFKKHGFRNPDNAQVLLKLNLFTDAYKGIGVAYKLQLTLHVSQGACERSFSALKGIKTYHRSTMTPDYLEAFMLVSVEKEILTKLDNEDIIDAVAAGFYSLRNAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVN9</accession>
    <name>A0ABM0JVN9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101864161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102618.1">
        <property type="nucleotide sequence ID" value="XM_005102561.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864161"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000658">
        <property type="entry name" value="PRK00029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153:SF15">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153">
        <property type="entry name" value="SELENOPROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005102618.1"/>
        </source>
    </evidence>
    <sequence length="717" mass="80644" checksum="28127B591D603BB4" modified="2025-10-08" version="1">MSRNFVKCCISTQRSPEHVAAFRGLQHCHVPQPGRGRQSIRSYSQSSSEYSDSRRSHHRTQSARNIICLAGYAVKRFVHKMAGASPTLETLNFDNLALKSLPVDPNVEKTQRQVPGACFSQVSPTPVKRPVLICKALPALALIDISEEESQRPEFVEYFSGNKILPGSETAAHCYCGHQFGYFSGQLGDGAAMYLGEIVNSAGKRWEIQLKGAGLTPYSRTADGRKVLRSTIREFLCSEAIYHLGIPTTRAGSCITSDSTVVRDIFYNGNPKDERCTLVLRIAPTFLRFGSFEIFKPMDSETGRQGPSVGRKDILTTMLDYTVKNFYPEIWASHSSNKPVMYVEFYKEVVRRTARLVADWQCVGWCHGVLNTDNMSIVGVTIDYGPYGFMDRYDPDFICNGSDDGGRYSYQKQPEMCRWNCVKLAEAIKDAVPLSETKPHIDLFDEEFGAQYKKKMRSKLGLQKEISEDGNLVKGFLDTLQETGADFTNCFRCLSNLPLPSCPTFNEERSKVLDYLISQSSSLDELKLANKPRMDKRQLSMFMMLAQTNPDLLSALGRSAQLLSSEMERMGRLQELQDTTAAEVEENNRSKWNEWLDKYSERLKKEEEGVEDRETLGKDRVNVMNSTNPRFILRNYIAQNAIAEAEKGNYSEVQRVLKLLQSPYSQEVDFELSESSKATQDKDTSETESSSGASACHVGLLDYAGKPPSWASELRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVT0</accession>
    <name>A0ABM0JVT0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Angiopoietin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102687.1">
        <property type="nucleotide sequence ID" value="XM_005102630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859028"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF394">
        <property type="entry name" value="ANGIOPOIETIN-RELATED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046764556" evidence="1">
        <location>
            <begin position="28"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="152"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005102687.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44381" checksum="7B67CE96A42F21E0" modified="2025-10-08" version="1">MNFDESCGQRLFALVLILVRSMLSMLTFEVNQCPTGKLCGGSRREIVPGVKGLLSCARHCGKDRSCLGVVSRETEWSQRVGTQANECHMLRACYNSLTSKECDEQMPQPFEYYAKVGDIPDLTLTSSVCQKCGVWDTTENKCKCTEGSAGVFCELDVYGSCKDFFNTESGRKTEKFYSVYFKLENGSPTFRVLCSLSPNGKEVRTYMFKSQGEVNFNRAWHDYEEGFFYDEANRWIGLRNINILCESMKNPMGVLETVYQSGTNRRRYNNFHDGNSSTNYILTVGKVDFSKNGDVGIGTTAKLANCLAMSNDAPFSTYDSENCDCQQRDCVSRAGAPWWFKNCTIECSPLGRKYVNLPQPQAEDRILLPGHNLHDSVYAEEFKYVGLFFKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXI1</accession>
    <name>A0ABM0JXI1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylserine lipase ABHD16A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103864.1">
        <property type="nucleotide sequence ID" value="XM_005103807.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857737"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054518">
        <property type="entry name" value="ABHD16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF72">
        <property type="entry name" value="BAT5L PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22990">
        <property type="entry name" value="ABHD16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylserine Lipase ABHD16 N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="269"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005103864.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="59546" checksum="E8A6588C9A725468" modified="2025-10-08" version="1">MASKLLWTFYGPRLLRIFKTENAQGHDYVPGVLESFPDKIISTFNTALGVSYWTSPVIGAILYRKGYFTQEGAGSLLRVALSMFVVYAIAYILRGIGRFSNAEYRDFISALVAAREKPTVDSKKQLAGYDFEFWAWPVDFRWDDGSSSDKKNAKKPAVVNSRRAQAVERSSIPCRFLSYLAMHSFGRRMVYPGATSLMNYAVSSMLNSGRAALVEEKNGHRAKVLAEGGNEIDTMFVDRRGKHNNGKTLVIAFEGNAGFYELGCTGTPLDLNYSVLGWNHPGFGGSTGVPFPDQEQKAVDAVIQYAIQKLGFEPQDIALFAWSIGGYTASWAARNYPDIKYVILDATFDDIVPLAIAKMPESWKSLVGLSLRTYMDLNVAEQLLDYKGPVLLVRRTKDEIISTEAPPNSEPVIGSNRGNFLLLKLLQHRYPSLVDSTTLPMINEFLAAETYRQAEMLQERLVVPEECHKVFSQHVAESGTNFPMALDVKGDEGLKIKLALYLVTVHMENFHSTHCTPLPGNFFHEPWVPQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZI8</accession>
    <name>A0ABM0JZI8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adenosine receptor A2b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101849312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105209.1">
        <property type="nucleotide sequence ID" value="XM_005105152.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849312"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="41"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005105209.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37487" checksum="0AC6738D53853711" modified="2025-10-08" version="1">MFPESFNGNVMTTVQTSTVSEYHEPYYYVVHSVLYTLSVLLNSVVVFVILRSERLRTPTNFLIASLATTDTIYAVGEAGYAIETLLIMNTGRAFMPNSRAWLSFVSSMYVCGKMSNYFHLMSIAFERWVYIVRPFLHERLVGNKRICLILVIIWLFSFFAGLDILIKQQVVNSVKDAPVRFALVYPIVHFLCSAVICTVYVHIAIISHRHMQAIQAQELSFLAAANERHRLRSLKSNWKIVRMVITVFGMFFLTVTPVVCLHAYLVHSNTSMTNMARQILPLLAATHYCSNFFVFFSQCKMFRDMLFFCKSKVKVGALGGNNVSVNTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0Q2</accession>
    <name>A0ABM0K0Q2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101855898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106017.1">
        <property type="nucleotide sequence ID" value="XM_005105960.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855898"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005106017.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32460" checksum="91E743A251A4EA8C" modified="2025-10-08" version="1">MLEDLVNGIENSRLVLVTDTADCPGRTLFLNWVKSLAERLDRLILICFERQPEFFKSWLPLGLQNRITFVDGQSITCDFELKNQDLFKVTTAAVPEFKGQTGVLIDSLSLHILFQQTPAVCSALHRLASDKRFSQVVAVLHRDVHDPHTCSLMEHVASSVISLRNVHSGKHICHVRHCRPTGKVFRTVESFTVDDSFHIRNLKPHQSASENVTLSQVTPEADPISQLSFNLSLTETEKVARSQVKLPHLKTGFDESSEVDSTLQSKIHYEADDADDFDEEDPDDDLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K183</accession>
    <name>A0ABM0K183_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase mind-bomb isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101858963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106369.1">
        <property type="nucleotide sequence ID" value="XM_005106312.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858963"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="65"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="214"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="387"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005106369.1"/>
        </source>
    </evidence>
    <sequence length="562" mass="63622" checksum="1984DD987A5DF450" modified="2025-10-08" version="1">MGFPRPECFVCKDELIRGQSFVFLKDPKYILCMVCYDRQYIGGHETFSVYFPQQENVSSGSDVVHTGVQCDACLVNPIRGIRYKCRMCPDFDLCANCKGQGCHSEHNMTEIAVPKTKKENVSSGSDVIHTGIQCDACHVNPIRGIRYKCRECPDFDLCANCKGQGCHSEHNMTEIAVPKTNVERRIDRYDDSVMVRLLQKPCVANRSSGRAYFHHGIKCDACNKNPICGVRYRCKVCFNFDLCSFCKINGRHSDHTMEEYGPCRENKTDPRFMLTLRNWIQHLQERERYSLGNHDGESEPSEHDHIHFSIRCDACGVCPIRGIRYDCRTCLNIEICADCKALGRHSFHSLREIVTTSAQRERIMHGVGDAMMGASLVNEVSSDGKIHTGIICDVCGMNPIRGIRYKCLDCPNYDLCVSCRVAKHHSHHHTAEIVTPRSPEQRMLDRRRDQAMKLILNARGSSSRRVTTSNSTEAATGATSQSTGPDHHRGANSPKVSDPMKSHFDEVDPEDVKERMTCPVCLDKEKTVAFKCGHCTCWNCSEQLKKCPICKKKITTRIRLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1U8</accession>
    <name>A0ABM0K1U8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB/POZ domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005106750.2">
        <property type="nucleotide sequence ID" value="XM_005106693.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847524"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005106750.2"/>
        </source>
    </evidence>
    <sequence length="448" mass="49954" checksum="2FF4DCEAFE5907C7" modified="2025-10-08" version="1">MSKSTQNNDATEQKRPKLDIPDDWQSIDDVIKSNQLMLERQYACDVFFLLGEQGVRQGAHKYVLISRSTVFDSMFCGPLCDSEASVASLDIALPDIEPDAFGSLLNYLYSGSTDVTADNVIPLLYAAKKYAVAGLINKCIAFVENHLDAQNACAVMEQAHFFDERDFQKKVLVVIQRKAEEVLATDDVTNLCEECLTTIVQSDQLMTKEELVLSACKRWAESECQRRGLCVSDENCRIMLGNTLYMIRFPLLEPSIFVKEIVSGSLLSEEEKVDVMGRYIVASREGTFFNSNLRTKQRHIRVHRFQGKKEYAFNNRSGSNAISFEVSKDVYVEGFIIFGTCRTGEHELEVKGFILDPADKVMCSVETSVVTSGKKDSYDVIFDESARVHQGTMYTLVVDIKGSHTFAGEGGRMAALSNDVIFTFTHSEKSLTGTTVSHGQLPGLICSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K344</accession>
    <name>A0ABM0K344_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein HEXBP isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107661.1">
        <property type="nucleotide sequence ID" value="XM_005107604.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860768"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107661.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23091" checksum="E6499B4650D18182" modified="2025-10-08" version="1">MSGGDCYKCGRPGHWARDCRNGIGGGGGFGRDRGGPMRMDFRNGRPGDKCYKCNRAGHFARECRMDQDRCYKCNKLGHIAKECDKDIDSGHGFSGACYNCMSSGHVQRDCPEVSSRPCYRCGESGHLARDCPEDRGQDDRKCYACGGVGHISRECPTAIRSNARDCYSCGSSDHLARDCPNGTSNTKCYNCNETGHIARDCPSESNDIVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4B6</accession>
    <name>A0ABM0K4B6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC1 domain family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108422.3">
        <property type="nucleotide sequence ID" value="XM_005108365.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860446"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="137"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108422.3"/>
        </source>
    </evidence>
    <sequence length="307" mass="31594" checksum="9EBF6A52A1C456EF" modified="2025-10-08" version="1">MAGGQKKPAALHMDFYSDSDSSRGNLSINEEATGGGGSGSGQTLASSSGQSYQDVFSQARQQQTASPTAGPGRRRHGSNTDENSPGGAANKTSTQGSEVSLGRLRHPSGDGEDAGQSGGGSGMPGAPPHTANRIMVLQISQQDISLICLEKKTPILERYFKDISFVSQGSHKQEVFGIVVRESSSMFICYLVKCLTDSVVSEIMSTLQTAFTAAYSKTGSTAGGGAGGGTGGSSGTAGNTPVTPTTPGTAPNELCTSCPLHQLHRLCQEITTDSSTKDGHTCPDDGTKITNCDYSENGTSLQINASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4U1</accession>
    <name>A0ABM0K4U1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Muscarinic acetylcholine receptor gar-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005108759.2">
        <property type="nucleotide sequence ID" value="XM_005108702.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858518"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="59"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005108759.2"/>
        </source>
    </evidence>
    <sequence length="581" mass="63630" checksum="A1CE80EFB3F13439" modified="2025-10-08" version="1">MALEASTLGVKDNATVDNVTVVEEAERIAYIGQLQEQTKLIMLPTIVFLVCCAVVGLFGNTLALIVYFRKVRRTATQIFIMVIALFDLLTNVTAIPADIYDMFHNWDFDDAAMCRVRHFFTSSTALASGILFLALSVVRFQKVCRSFGRQVSVRQAKAVCVIISAFSSIVSVPYAILYGTETIPSPRADIFGSECGIDDRFTQTVWPAAYYSCILLLFLSCCIPLVVLYTLIGIVVWRHSKLYGVSALPSAQVKATSGGNSPSITSGAVSLPSNDSSSRGAAGASGEDSVEMTDLENAETGNVRQEVCRESPDNTRKEESDVSSGGRGMPKTTEMGKIMFSSERDGSGQLGQGKRRRHDGAVESVSDREATDSCSCQQNKAKQVSVPTVEKVLSCNQTPSGEIYIPGPSSTTLTKKEKKQSCDVSGDPNNKQNYAKNDPRGQTVEISTTTSPSKKRRQGGVIQILSRRDSQKKSPKLSTTSTTSTLGQATRRPGLGKTTMMLIIVSFIYIIGFLPHLCVVFFRFASPEKFAAMGTIEQIFYNLALRFFFLNSAANPVIYSLCDRNFRLDCLQVFQCKRKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5U6</accession>
    <name>A0ABM0K5U6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101855827</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109426.2">
        <property type="nucleotide sequence ID" value="XM_005109369.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855827"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="903"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1189"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1241"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109426.2"/>
        </source>
    </evidence>
    <sequence length="1398" mass="150878" checksum="3B0C7DC0E59CBE23" modified="2025-10-08" version="1">MCKMDRKRCCQFLSHWYDVKVEGVRLRDWCRPLPEGRVKCSNCKIVIKYSSTGLKALKRHAHSMKHQENRAAQLAVKKKKAKAVAKAKSTSAVKNLPVVKPKSLVKQRPLTSSKSLSVGKSRPVVKPKSVTNKSVPGVKARPVSSKLVPRVSGPKFLSKPLQARSNNSSSSRKLLPVPLFTKVSSGSSVDRRSVLAAGGGERKEAAGIAVRTGGLVLGPGRKRSGEGRDVLSQLDRPLTIDVFVAGKKTEQTKGSPAEAQFIFGVKRGFVDVYICFYCGEEFSSRPVLREHQWMCDMKPPELQAVTPPGWAAQPASILSSGEPSPASPLPPLLCALEQDPASPYLTPQKDSNSCPYQQPSTFVRPPKESFVSALGLLPKKKAAQVCRKRRNTECESINLEEDVPVSPLVPRTPKLLISHLSREGREVNNSSEQPPSQSPSLFRRRLSLFSQSSRTEKDGQKEKEEEGSSEGSSSDDDDGGGGGGGGGRGKVGRPGRRNMTVCKSLYNLPVTSLLGQFVIKHFKGDPSLHVLSDIESHCLTSTPKKSPTAGRLRERRAMYPTTFRGYSGKAYPQHFHQYKFNSVQTKDFLRRVNTGLDKPSRKLKRSMPACCVRLVRISPRDLKRWIPSQNQLTVHLKPLTDPEIAFWTSPKRASAAESASVFPSGLSFSSPNVQKILGLRTKQEAAASRWRWPLSLSHVVSEEACAEMVQNRRRLFQSLICDSASGESGSSEEENSPSRAHSVLRRLLSTASPYLPFRQPCGALPDITNLKVDEGKDRLLQLSRTQVSGSLSEDCGDGEKKKVAAFGPCVSERQQGGRTVQLCERGGLAVPCVTVRSSTPQPPAHLPHQQIASSQTKPCLTTVPRLCGGHTVPLRNSTSEGEIIQPWTEQYATHRSSSLPASARHDKSSVDDAITDKSKLSSSSSSSIRPTRSKPDVHQDRQVIDRACDQTIVVATVPASKRPVHKELSLTLPPAPPKCPSLEQTSARSVWETQRNVAAGCCSAVCGTSSTATAEGKLLPGGAKIATKEGKSPPADKATIERAARALRLAMRNVASHALRHRVKVKETVSERQDDTSSCPEKVDDRSLTSCSENGGGGDDEVDGMSSTFPTCGGLAGGTTGNVMGGGEEGKDAGRVSCDGGGSVRERDMRTLRSLLSSSSSSISARATNSGSNATLSTKSRADAIPSVVKTNGTPEVDRGNSTLPVNPSAPSFLSSSQDQWCRRAGTPTKRLPERSSPRNTPTPNPPTPTPTPPPDADAATTDVASAAPQKSSSKHCVLSLTGNSLSPGKFGSLVRISSSSSSLSSPAKMSSVKSGRDSPLSSWRYERGLRELNPSTRGSRTPPQQQIQQQQQLRRASSVGKSMSVLQRAEFRKSLGTSFLLDAGQRKGQKVQVNWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6E7</accession>
    <name>A0ABM0K6E7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850118</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109829.1">
        <property type="nucleotide sequence ID" value="XM_005109772.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850118"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005109829.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11613" checksum="D8096B0EA2EB23A1" modified="2025-10-08" version="1">MYSMAIQLCSNSEGQTFAIDADRVILTLHGLGASFRLRLQAVDRSGKGSRSGEDSGFKYYGTVGGVCAAVVAVMATAIGVYFVRQYRMRQQKQSQANAETIVPLGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6S2</accession>
    <name>A0ABM0K6S2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101847223</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110069.1">
        <property type="nucleotide sequence ID" value="XM_005110012.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847223"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045905800" evidence="1">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005110069.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="28973" checksum="40C191946B0726F7" modified="2025-10-08" version="1">MASSLQIASVLGLLSVLFTSSLAALTPLSPCPNNFFYDALYDLGAGTVCNSNHVTVQEALLGEGCSTRGTLKISLASASQDPGRRAVLIDLFFNNSRGFSFNLGDSRTNNGYDGDAGTTQYDTEIHTVSNNGFRIYPGDKVAAAQQTPTTVLNAFSTRLTLIVRDGKVQWVSDTAFNYLEGSGIFGLNGQTDDVEARGVANYDLYLGLNKVVYGWSRMGSGLCKAAIRFLCDNEVRQVTSRRSDRRQPRRERFFPRRIPARRALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7U7</accession>
    <name>A0ABM0K7U7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intraflagellar transport protein 56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101856615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT56 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110847.2">
        <property type="nucleotide sequence ID" value="XM_005110790.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856615"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110847.2"/>
        </source>
    </evidence>
    <sequence length="556" mass="64211" checksum="3DAB840A8A6607AC" modified="2025-10-08" version="1">MMLSRTRPAVGPGAAPTGKDVKKKKKMPTVEEFLDMRDYTGAITLLEFSRNAGKGNEETDMWIAYCAFHLGDYKRAMEEYERLTKREGVNPDVWLYLACCQFFLGMYPESDENAAKSGPKGRLQNRLLFHLSHKFGDERRLMSFHQNLQDIIEDQLSLASIHYLRSHYQEAIDIYKRILLDNRDYLALNVYVALCYYKLDYYDVSQEVLAVYLQQFQDSAIALNLKACNHFRLYNGKAAEAELKALQEMASPSFQFAQDLIKHNQVVFRSGEGSLQVLPPLIDVIPEARLNLVIYFLKQDDIPEAYNLIKDLEPTTPQEYILKGVVNAALGQEQGSREHMKIAQQYFQLVGGSASECDTIPGRQCMASCFFLLKQFEDVLIYLNSIKSYFYNDDNFNFNYAQAKAAVGNFKEAEEIFLLIQNEKTKNDYTYLSWLARTYIMNRKARLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYAAKAFDVLERLDPNPEYWEGKRGACVGVFQLIIAGSEQRETLRDVINMLRNTSNPQVEYMIRTMKKWAKDNMVPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8C7</accession>
    <name>A0ABM0K8C7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="1">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101845369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005111198.1">
        <property type="nucleotide sequence ID" value="XM_005111141.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845369"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="8">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="7">
        <location>
            <begin position="125"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="237"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="510"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="770"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005111198.1"/>
        </source>
    </evidence>
    <sequence length="806" mass="89563" checksum="3D422F28C428FF04" modified="2025-10-08" version="1">MATPEAKAEEDLATAILRRKERPNRLLVEEAVNEDNSVVSLSQKKMDELQLFRGDTVLLKGKRRKETVCIVLSDDSVGDDKIRINRCVRNNLRVRLGDIVSIQPCPDVKYGKRIHVLPIDDTVEGLAGNLFEVFLKPYFLEAYRPIKKGDIFLVRGGMRAVEFKVIETDPQPYCIVAPDTVIHCEGEPVKREEEEEQLNEVGYDDIGGCRKQLAQIKEMVELPLRHPQLFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRSHVIVMAATNRPNSIDAALRRFGRFDREVDIGIPDATGRLEILRIHTKNMKLGDDVDLEQVASETHGHVGADLAALCSEAALQQIREKMDLIDLEDEQIDAEVLDSLAVSMENFRWALGKSNPSALRETSVEVPNVTWEDVGGLENVKRELQELVQYPVEHPEKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKSRGGNVGDGGGAADRVINQLLTEMDGMSAKKNVFIIGATNRPDIIDSAIMRPGRLDQLIYIPLPDDKSRIQIFKANLRKSPLAKDIDLDYLAKVTKGFSGADLTEICQRACKLAIRQSIEAEIRNERERAKNPDADMEIEEYDPVPELTRAHFEEAMKFARRSVTENDIRKYEMFAHSLQQSRGFGGFRFPGAAGQQGQSGSGSGSQGGNFAQDDGDEDLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K907</accession>
    <name>A0ABM0K907_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101855536 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111738.2">
        <property type="nucleotide sequence ID" value="XM_005111681.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855536"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111738.2"/>
        </source>
    </evidence>
    <sequence length="606" mass="67055" checksum="20AEC20DD4C788DD" modified="2025-10-08" version="1">MPLEERRHSGTPPAAHRWKRTSPWLQQFRGAHRDESHKYSRADVATPSPIRRGGNIINAPYRGAESPQRRDDKTLGDTSFNDVISCLRRVLSQETVYQAAFILACASVLAVLSVLSGAHYTPWLDVLVLCVFYAFWICHCLPWLILRLDGKKILLLVGVVLRLFAAELFLLAWGHFRGHRDVLQRALRLRPVLEPSLSWLPQAGYCLRYGVIVAAVVTCISSLTQNFVEKISRLLRHRRLSPTTKPSPTKSSTAANIPEHSTKSLDLQDRRSDRRTSPFVLGGDRPRFGVGAKASLPAHGVGGKNLFNQLRCDKDLNPNEIDIVERFFDSSYSLCRPNRGRNGAIGRGSATRNEILDTNFGGTQSFFLDSGSGGDTGYNTRMYNRKPSAVVFKGVSPTEREGQRGALRRGGSREQLVDNIVDASGVVDPTERRNRSADTPKLRYRGWKTTKCRTGGKRAGFETNAASRTRKDADLTLSPPAGLLHNHATTKDLLKTVSGQTTKGLLNKGVVVSAGKWKGRAGADPRPDLQPPVRVRADGNNATTTTFTKEAAARSRSRWSLGSNQRQLFQREFLPDVSGGARGGLDDSSPQQDLEKTWEDLSSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9J3</accession>
    <name>A0ABM0K9J3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101853209</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112147.2">
        <property type="nucleotide sequence ID" value="XM_005112090.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853209"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005112147.2"/>
        </source>
    </evidence>
    <sequence length="580" mass="62359" checksum="58C8AE68EC35EAEA" modified="2025-10-08" version="1">MSSDSNNPCSAVVSADDVPAPANTTTATAASIALTGVNNKNGSSTIINRSATTTTTAPPQTTTTLATATTTTTATTTAAAVAAATTSAAAPSQSTSSSTTTNNTLSPFDLSGLGMGFGLYRPRRPSYTFATKCNRQRNESYRHATRRENLDSTSEPMSADGDFIEDVLRSRTRKISYIKATKFSEEYGSTSACGVSTSHVIVPGSDGDDDDDYDDDDDVLRIEDGTRGGSQLSVHSRTSGFETIKVTLNNHSDNILTNANNDEDVVFCESQNYLNHKSAQNCPSLQGSKVNSLGRGDSKSTGTWRSSRFKLEGSKNVSNIISTFTFHKNVIVLCCSFILVFSSFQAIQNLQSSMNSEGNLGIYTMMSVHIAMIFSCLVSPIIINLFTAKWALCIGIHCFLIWFGANFHPTFYTLIPTSMFVGLGKGILWSAENAYVLRLACESSRVKRTTLESEMFRFHGIFLACFQTTHIWGNLISSLVLSSHAKEVSPPMSFPDMGGADGSPGYEGEGADGGVAYPELPANQSSSYYSSYDRNYEGGGMSGEMPPMLLMSQCGALHRCGKAAMTIFPGVMQGKTRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAC3</accession>
    <name>A0ABM0KAC3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC101860068</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112751.1">
        <property type="nucleotide sequence ID" value="XM_005112694.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860068"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="73"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005112751.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43078" checksum="AF306D1CAE352FFA" modified="2025-10-08" version="1">MNTTATISNVSVEDTTAFSTILSEKTLGLQVTTAVPRKIKVHSGVVSDAVYFYFETYVDLWLCMVIALLGVVTNSLTLAVFIKQGLRDSVNISMATVAFWDLTKCIGAVINRMYGPISWFSPAFGQSWHHMTLPSLGYLPIFAGYVSYALAAYIAFERCLCVMIPLKVKFLLGPKVTLAAVLIISIAVFGAYAIVFFLYKIVWIYNPVYNTTIAEYTFNDFYKQHGRMIMAYYKAIAIILPLFSFVIVVICSVLTVHGLRRSSTFRTSAQNVKDAQTDSKSKLSGKDKQIAKMLMAIIIVYIVNLFPRIIFGIAQLAEPEYYVLGRYHNLFMSTANCIFVLDFINASINLFIFYRMSSNFRATFNALRRCHDAGACKFAVGANCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAJ3</accession>
    <name>A0ABM0KAJ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase rififylin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101846052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112901.2">
        <property type="nucleotide sequence ID" value="XM_005112844.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846052"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858">
        <property type="entry name" value="OS05G0521000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005112901.2"/>
        </source>
    </evidence>
    <sequence length="127" mass="14533" checksum="9E27533E9F968BE5" modified="2025-10-08" version="1">MGKTLFFRSGSQPLILSEEQRAERKRARQEEMSSSSGLGTYLERLIPGLKHRGNYNPKDTQDEAAAIIPSDLDRDCAICMDRLRDCLFRPCNHMVTCLECGQMLQARQDACPVCRKDIEQTIRVFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAX4</accession>
    <name>A0ABM0KAX4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ homolog subfamily C member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101859303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005113197.2">
        <property type="nucleotide sequence ID" value="XM_005113140.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859303"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="78"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005113197.2"/>
        </source>
    </evidence>
    <sequence length="287" mass="31028" checksum="1E22718177F6D49D" modified="2025-10-08" version="1">MSSPRCCPHLKSVACWTCSRPDDLQPTHAAARSSRSPTAHNASVVLYRRQHPLFWAPSAGGRPKRAGSEGDLSRSGNSLYDLLGLKKGATHDEIKKAYRKLALKFHPDKNRDSPDAAEKFKEINRANVILTDGTKRGIYDRYGSMGIYVAEQFGEENVNTYLVLTSGWCKALAIFCGIITGCYCCCCCCMCCNFCCGRCRPMPPGEEGSYCNLHEEGSNSPEEPITSQPIPMGGGSKLEDEEEEDVDEKTNIKTSGQPTYGADVVAAPPPPSAGGDDTSAALTASKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV19</accession>
    <name>A0ABM0ZV19_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease Oy</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106011115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935047.1">
        <property type="nucleotide sequence ID" value="XM_013079593.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011115"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047237665" evidence="4">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012935047.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30987" checksum="4F81F9648CBD8077" modified="2025-10-08" version="1">MSVYSFTWIFCVLFVVNGFPGTSSFVVDVDTYETPTKEWDYLAMVQFWPPTSCYIYFGKEKCHGIPAVVKGWTIHGLWPSGPGSHYPEYCNHSLKFDYNKIKSLGAQLLTQWPNLDSESKTTELWSHEWEKHGTCAVSVSRLSTEFDYFNVTLGIHGALNTTGALAKRGITPSDDPYTASDIYNALLAEYGVKPNIVCEKKDEKYYLDQVYVCLSKSFVAQDCISSSGEPFLGSLFVGCPDPQSREVIYMPFNTQQIPDRPDNILEFISERDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVC7</accession>
    <name>A0ABM0ZVC7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101859466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935251.1">
        <property type="nucleotide sequence ID" value="XM_013079797.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859466"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="543"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="523"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012935251.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="75105" checksum="FEC2A38CB2879A81" modified="2025-10-08" version="1">MAQKAPSLQSLYVELNRFGQKQEFEKAVKTCGRILHFYPAEFSAFQCKIVSLLLLDRFEDALNALNKDKTHSVGLKFEKAYCEYRLNRTTDALATLRSITEHDTRSKELLCQVLYRIEEYEECYTLYKDLIKNSEDDFDAERQTNFAAVIASLQMWDVRDMSDPGLDESSYEICYNKACYFIGKGDLDTAMDMLAKAEELLKNDPDLTEEELDEELAIIRVQRGYIKQCLNKNDQASQLYNQVLKTKPSDMGLVAVVSNNVVTINKDQNIFDSKRKIKAASGDGLKHKTVSAQRKHISVNQCLVHMYSNQSDQCHQLAKRLHDQYPDLESPVLIRAAQFVRDKKMDEALALLKEYSKLGKNQSERAQLILAQLQLAQGSVYQACDALKGLGDLAYCPGIVSTLATLYMSQEDKEAASEVLTNAVNWYKKNDPKSSALPMLTRANADFQLKNGRAEAAAKMLEDLRSSSPGDALVLAQLISAYALFDSKKAQQISKDLPSVEKIVQGLDVDALEASFSTLGPKYMKKQQPAKGEASPVTSGDTRSGDTVMLKKKQRKKKKGKLPKNCEAGSDIDPERWLPRKERSYYRGKRKDKRKEIGKGTQGMSAATQAITDSLDASKQTGSGSEPASPRPSGSGGSPSSPQGSTTSPMPMAQGPRQQKPAAAKKKKKGGKGGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVU5</accession>
    <name>A0ABM0ZVU5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Carnitine O-palmitoyltransferase 1, liver isoform</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101858816</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935595.1">
        <property type="nucleotide sequence ID" value="XM_013080141.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858816"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032476">
        <property type="entry name" value="CPT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF31">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16484">
        <property type="entry name" value="CPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Carnitine O-palmitoyltransferase N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="12">
        <location>
            <begin position="174"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012935595.1"/>
        </source>
    </evidence>
    <sequence length="765" mass="87482" checksum="2A2EAA35747820D4" modified="2025-10-08" version="1">MAEAHAAVAFSFTVTPDGYDVNINHEAIKAVWESGVLSWKKRMGRLKNNVRNGVFPASMTSWLFVVTLILGIRLAGFDPSFGSISLIHSTMPGLQSASYSVGLYCSTIVFGTVLWIVKFLLLKYMLKLLLTYHNWMYEVRGKMSLKTKLWFMLIRLYGGRKPLLMSYQASLPKLPVPGLRESVNNYLHSIHHLMSDERYEEMKKLSEEFCSGVGHRLQRYLILKSWWATNYVSDWWEQYVYLRGRSPIMVNSNYYGVDALLVTNTTVQVARAANLIYAMLMYRREVDREELNPILINHVVPLCSAQYERQFNTTRIPGLETDHLVHLKDSNHITVYHKGRYYKVYIRHKRRMLKPCELEVMLQKIVDDESEPAEGEEHLAALTAGERVPWAKARKEFFSKGKNKASLDAIEKAAFCVTLDSEDQDYDPNDPTKLDKYGKAMLHGKGHDRWFDKSFTFVVCSNGRIGFNAEHSWADAPIMAHMWEYVVTEDVATYGYDKDGHTRGTPECQPPNPIRLEWDLNKQCQQVIQSSLQVARSLLNDVDLHIMMFNTFGKGFVKTCKVSPDAFIQTAIQLTYYRLEKHFCLTYESSMTRLFREGRTETVRSCTADVCNFVRSVCEGKPKADSIKLLRKSADTHQKLYRDTMTGAGVDRHLFCLYVVSKYLGVDSPFLAQALSEPWKLSTSQTPHQQTDRLDLTKHPDRICGGGGFGPVSDNGYGVSYMIAGEDTIFFHISCKRACGHTDTHKFGATLQQSLCDMRDLFSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVX4</accession>
    <name>A0ABM0ZVX4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier organic anion transporter family member 4C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858313</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935635.1">
        <property type="nucleotide sequence ID" value="XM_013080181.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858313"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF142">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="763"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="695"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012935635.1"/>
        </source>
    </evidence>
    <sequence length="894" mass="96714" checksum="B7B97CF2E234E693" modified="2025-10-08" version="1">MNGNGSNGDRMDKDSEEAVAMMPQSGWGGGKAETLEREGRGEEGCGVGTCRPQPLKKCGGVWSFTFVFGLTCLLTNSLKTYMTTQLIFLERQYQLSSATTGILVSCTDIGYLIFVLVFSYFGRKWNIPKVLAISTSVFGVAALICAVPAAVTSADVIDPPVVPAEKAMTMEKLLLSVPSCTMRGIPPEAMSAMMSGMSAMSSRPKPRPKPIVVQPVKTPPPPPPTTAQPPPPPPPTSSAPETRPPPPPPQPKTPAATTQPPTTTTTTTTTTTTTTTTTEAPFEGEPIQMPNFTKLVTHPKYPEMVQMASMFEIDIPSVAALSLKDQVKYVQNLPPDIKEMLPSMKMMLQPDPDSYFFLVSPSGKILPPRNKRAAEEKKKKEKPEWIDISKDMMYSGKIAKMMARFLPLPQNMVDAMYTKLCPFNTGPFHEDTTATEIVIALVAIGMVIQGISRAPLAAFSTVYIDDGVQQSRTGLHLGIIYGLSTFGLAIAGGTGAFAATSYFTVEDVGHLNVYHPRWISAWWLGYVLYGIHALILAFLLLSFPRSLALNSDRAFTNNNKQDSKKASRISRESKGFMTGLFRLLKNPLFLLVVLGNAATVLAASGFAFHLPKYIETQFSLPPFEESAIVAMCYIVFAAIGTVIGGVLTTKLRLTATGCLKVTVAVAVLLVAVQATGIGLGCDQPEVDKGDKFMTNSSTTLCNNTCLCVDHMYSPMCGSDGKSYFSPCHAGCGLAYDGKYHDCKCVEGKMKTATPMLCEQPCNLFYAFSIFAVFGGFLFQSMFIPSFIATFRAVESRDMPLAIGFNSFLVTLLGAVPSPYLFGTIVDDSCAMSRPPCGPAGTCSFYDIVQMRLHYHGLSTAIRGVAALLYVVALVLACRESSVYKVKDEEKSRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVY6</accession>
    <name>A0ABM0ZVY6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862859</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935651.2">
        <property type="nucleotide sequence ID" value="XM_013080197.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862859"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF117">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012935651.2"/>
        </source>
    </evidence>
    <sequence length="556" mass="62853" checksum="EC27DA426FB82BE4" modified="2025-10-08" version="1">MSGDTHIEGVLQSGVIALSGGHDNAGNSLVTIPTSKLNDLTEWTVKDISAVVLNLARINKYTQKDKDQSNAALQIPPLSCLADLRQASVEAIHLLIDSLEAVEHQQRGTVRAVYFLKPKSKTRSHVLKKLLGVKPSKKRPRIPLFKIVLIKSLQELYSHIDVSQLTLDFCGTLRYSHQAWLHLYQVVVQCIESCQALLSKLPSVKDKVELLQEYETDGQSSNQLQSLLSDLAEKFHIIVEDSTLPNCLTQSKQTLFLLDHPASDSQLLAIHSDLVQGLHVYLRGLFTELDQWRRDLEETWRQTEVKLAGLIQMHKHQERSREIERKIREHYQPLLREHPIVGRTLSQAELYRAHFTTTLYEPAKELLSQATEILMAVQRLQASLQQSPGSGSAGREGNMSIEVSEISHCLTTSIQPFTYQLQHLQQLYVSIHIFHLLFEKALTWYKKVLKFLPDSLLQRCSVESGAQLNGPLGVPAARMESLVFMPAEWLSAVRVFLARHPPPRDEHVDRLDVNTPQQVDRKLRSQARSLALRHVLLSSVLSIVMSVDSVVQWLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX34</accession>
    <name>A0ABM0ZX34_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101862717</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101862717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936300.2">
        <property type="nucleotide sequence ID" value="XM_013080846.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862717"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012936300.2"/>
        </source>
    </evidence>
    <sequence length="284" mass="32795" checksum="FC3B5B066339089F" modified="2025-10-08" version="1">MVAKDVVAEIGMSPSNNLKVECAASKAWGWTYMSISRYEGDSDFSLEFLGGVEKRDEWPFIPIDSRMSDFTLHRDDEQVTLALETKYAMCEDKGRYLCEAIVNRTIFSKTFNVDVKKKPEPPKLSFPEDIFDGDTIWMTTTWDAGNPLLGHIVHEVIKGYKGLPFAAKNERTISWKKDCSIQVRNKYQVTPNLSWNGTELLVRIIPKENATLYEQNVVRRVKTDRKTVLIIDRNICKGKYNQKVAHPYTCSKYITCFRRPRVTKCGYFQCFNDKSKTCQHITLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXG4</accession>
    <name>A0ABM0ZXG4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106011430</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106011430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936507.1">
        <property type="nucleotide sequence ID" value="XM_013081053.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011430"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046061920" evidence="2">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="3">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012936507.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="25999" checksum="DAA1E9139DACFB64" modified="2025-10-08" version="1">MTNGKLLVLAELVECVACAICADGHALFSCDSESQVLTHISRNDIGEIVFGATEPVGLGTSLAASVAFSKEPSRLKDLLGDRRVPDGLTVSTNRAQSAMGLPVADDTEICIGVVEFYRYAKYSQFSEEEEEVASLLMVLGCTALAKAENVAQRLVDADRASLFLVDHHTNELYARIFDMGYDKKRSLPPAPDSDNNGTEVDPGGAQTAAVAERRTCEEIRSARTLRLHTFLLHANVSPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY07</accession>
    <name>A0ABM0ZY07_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106011481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106011481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936824.1">
        <property type="nucleotide sequence ID" value="XM_013081370.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011481"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012936824.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23581" checksum="7511249F656CD25F" modified="2025-10-08" version="1">MIISKTAQRTFRGWEVLGPRIITASFGYKKELTGREGRKKVVNVNIIQVYTPTNDAEEENKDDFYNSLHSVIDKLPDNLQKINQKFFQPEMTSNSYGTTFERGNCCSYNITEFRKEAGPDHIPPEALKADKDTLVEILYALFENLWQEKEIPTDWKEGHRIKLSKKGDLNNCINYKGITLLSIPGKVFNRVLMKRIKLATDEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ14</accession>
    <name>A0ABM0ZZ14_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106011645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_012937461.1">
        <property type="nucleotide sequence ID" value="XM_013082007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011645"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012937461.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25273" checksum="AED72426980612B5" modified="2025-10-08" version="1">MAFNFLPTSTGAYSSLSCFLQVLSRRFARTKKLYWARLPAEERTRFLSSRIFLSVRDPYTRLWSTFLHTLMLPDLWNSVGVKIEKNRGFDQIVRTPTKSKLCGMDATFAEFVDYILASYEADFDSYHRLCDPCQLKPTYVIKAETLLRDRQKVLEELGLPQVFAGSDPEEALIRHRINVTVMEAFAKRKDPLTERCATHGDVARRLWQNFIVHGDIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ80</accession>
    <name>A0ABM0ZZ80_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101849690</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101849690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937560.1">
        <property type="nucleotide sequence ID" value="XM_013082106.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849690"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937560.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="30339" checksum="38761E56768DBC9F" modified="2025-10-08" version="1">MMTPSVCAVSQTLVVRVFLLPVVWTALGFRLLDTALAASNYSTGTNATGVAVRNVTVAPAPGGQVTCNDITVEAVVFAALGGIVLGVVLTLLFFKLFHKRAQRLPPKDYIREESTVGTEDVVLVSANPAPDTRRRKSGDQGAEPEVHYTGSDSQRGDSEGVTKGHKKLERLVKPSKHLPADVEIPQAATPLIDEQEDSNDHPYTDVGEQGTTTTSGTPSNNNLPPEENGEGEGKLYTNFGETSKLEQPYDMLNVIPEEVEYTNTMFSTYQPLTPVKKKAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A363</accession>
    <name>A0ABM1A363_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855651</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939880.1">
        <property type="nucleotide sequence ID" value="XM_013084426.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855651"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF39">
        <property type="entry name" value="E2F TRANSCRIPTION FACTOR CC-MB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939880.1"/>
        </source>
    </evidence>
    <sequence length="799" mass="90137" checksum="0316EB18A8E656CF" modified="2025-10-08" version="1">MKIGRWGNVSFSLQFYQSFVLGTVVLATVAAVTNYLSQTWKTPISHIRVDKYRRQKCHVQAHLRLKSLRDQGSDGDVSEDEGRCRVFPMLHQSNYSSPAEAAKTSCRRVQPVPGSCHVAQEVFFSQPPPSCSHQEHIKFCQVETKKKQVTCSAKIISSVCASPPFIGLHNQSGRLQWVQLGTASSLAQALTDLMRRGQFGNFSKHFGFCFLRCDRTAGNGRETTEDEYAGNGRETTEDEYVPLADDLYDKNFGSDQEKAPSAEQLLILPPLVKTSSSRARPVNKSLINFNLVLVDSVSRQHFFRSLNKSVLALENLNRDFSSPVAVFDFELVQSVKSRTFESLQTLFSGDIDPSRNPFGTQEVPPEPLDLSLLLGKLKDKGYSNLWLEDLCHLWEWGLSKDLHFLNLTSPEQETWTRMWTRLAENFVDSIEVTLAMCRVFESCGVKDGFHGPEAICYNGRHQHEYLLDYLAGYQHTLTSANRPWFSFTMTNVGHEETGRRIQTLDLALSHYISAASAQANTLTILFSDHGNSYGRFVSESTEAQVEMFHPFLFFIVPRQVGRQLGVRAMRSLGVNSRRLVSLLDVHYTLTHLISPGWKVRERNKDYAVTEKGLLEPVGSARSCNDLALIPPNVCICEDFEREVSDHSGQELLAYFAVDQLNAEIQRQFAESHTRKGTTLNDTWAVQTAFGNCERLSLIGYRNVKTSFDKHRATVVKMDVLVQKSARFFVTMTIREEEDGRETVCEGRVTTDKFDRLTRYGQYASCADGVDLSLCLCQVPKSASPRRESTHGASPRREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A428</accession>
    <name>A0ABM1A428_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="2 6">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101851511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="2 6"/>
    <dbReference type="RefSeq" id="XP_012940405.1">
        <property type="nucleotide sequence ID" value="XM_013084951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851511"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="7">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012940405.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27014" checksum="BF4406070E784A6E" modified="2025-10-08" version="1">MADNNKYTVLLPTYEERKNLPLIVWLLVKTFSESGFDFEIIVIDDGSPDGTLDVAKELQRIYGENRIVLRPREKKLGLGTAYIHGIKHATGNFIFIMDADLSHHPKFIPEFIKKQKDGNLDVVTGTRYVGSGGVFGWDVKRKCISRGANYLTQVLLRPGVSDLTGSFRLYRKPVLEKLINSCVSKGYVFQMEMMVRARQFGYSIGEVPISFVDRVYGESKLGGSEIIGFLKGVLYLFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4I7</accession>
    <name>A0ABM1A4I7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DC-STAMP domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101852255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940694.2">
        <property type="nucleotide sequence ID" value="XM_013085240.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852255"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058842">
        <property type="entry name" value="DCST1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF9">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26037">
        <property type="entry name" value="zf-RING_DCST1_C"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045231591" evidence="7">
        <location>
            <begin position="21"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="8">
        <location>
            <begin position="25"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase DCST1-like C-terminal" evidence="9">
        <location>
            <begin position="271"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012940694.2"/>
        </source>
    </evidence>
    <sequence length="472" mass="54258" checksum="B8962AD5D8470361" modified="2025-10-08" version="1">MPLTVLLVVVKALLYRRGYLNKDNYDNCYITRYLMEIDAKRTEMEKETVFPLKTREKFKYIKTFSMKMTEKEAQKMVKGVLLWLFAAFHAGYYLLCDYGLYWILTLVRVHMDVRTKMAVPAHLQMHVQGQGPMADMYKAMVGVLEPVADDDLDIDTSQCLPKPSKPNFPVYQTVVGVLAVCFFLTVFEAYGLRLRHAVAACYYPQRERVRAVWLYNHILVTRGSFLSVARRQLHRKRKNEQDVQKISIRSRIVAQCPMCKPVMKCLGHNVKHCLCCGEEGKANDMNKFIHCDHCKTPYCNDCFADLGNICTACMNPVDYGDADDESVETDSSEDEQDKAVRVANLKARKQKAVEKRDERRPSQVMEAFQKRFAVASTASQLALLESQTSHVSSSDVDEELEEAEEEEETESEEVSSSEYETEYQYREPREDSQSEDSNIPPRKRSRLGSTRKRSEMVTTDIFHSSDSSDDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4Y7</accession>
    <name>A0ABM1A4Y7_APLCA</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101854811</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101854811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_013085469.2"/>
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    <dbReference type="GeneID" id="101854811"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EF_hand_dom"/>
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    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EFh"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="39"/>
            <end position="74"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012940923.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23466" checksum="43F674B606D87676" modified="2025-10-08" version="1">MKQQNLRLIDLFRSLDVNHDNAISKQELRNGFLSLNMQLPEGVFGSAFSKLDLNSNGIIDIDELKNAHRRVLRQTMLMMVRSKSNDENEGYGDLLHEFQKLVREAANKRKLPKQKEEPEEQGKAATPGRRTTTRRPTLSARRVSSINQSPITAQASSQSTEAARALDVPASQSQSSATRRLSSATSKNQMAENANDFSLNLGSPGRQDQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5F3</accession>
    <name>A0ABM1A5F3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Slit homolog 3 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Euthyneura</taxon>
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            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_013085726.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="35"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="52"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
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            <begin position="73"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941180.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14577" checksum="73F012756C6DEC51" modified="2025-10-08" version="1">MAPIRDDKAVENPCDDWECAHGECSLDGRTPYCRCNEGYTGDHCDKAVENPCDDWECAHGECSLDGRTPYCRCNEGYTGDHCDKVVENPCDNWKCVHGECSLDGRMVYCICNEGYTGDHCTDFVGITRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5U1</accession>
    <name>A0ABM1A5U1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger and BTB domain-containing protein 49 isoform X1</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="primary">LOC101862600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941394.1">
        <property type="nucleotide sequence ID" value="XM_013085940.2"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012941394.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="61575" checksum="1C6EA881082D422E" modified="2025-10-08" version="1">MPELPLDVAVANRFISSLSKSLQALCHGCMDFDSGIEIVGYINVNIDCGSKVDYVLNEKVLKSTTNSMTFVSNSFLAKKDQPKQTRDGSCSPVAELQVQSFPSSSRHRGAHPYPGALHHRSAFPYSQTHALRGAQKRAWSGMERDWRASPRKHSRGGRGSYPLPHEQPYGGSSSHTSSFETQSSQVPSTSDSSFLQPEIPVSNSGVNIKKELFDSEDQSGAGQSEAGVAGESEGGNGDSSLDSKLNIKADPDAVPESEGDPSAGPSEDANTDLKDTFLQQSGEDAEQPEPGDSAQDAEGEFPSFDMAQSESAADNGQTMSEDTTAGAEQTDDNVTAENSEAPAEYDEAGDDMSYPQSSYAEQGEGSGDGGQFEVIEIDDEDEDVQAMFGDAQAWCYIPSRDEAESSNMTNRPIASCRSYSGAQMPSSFRSENVRGMHQSQAAMPYSGSGSFQVQCRICAQVFSHSTILKSHIYECHPREAQNAFPYVCSICQKGFFSHSGLTHHSEKHSAKFECYLCSKTFSYSRNLKRHQEINHSLKECRYCKRLFKVGEELNHHVLSCSGANRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A613</accession>
    <name>A0ABM1A613_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Atrophin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941520.1">
        <property type="nucleotide sequence ID" value="XM_013086066.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012612"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941520.1"/>
        </source>
    </evidence>
    <sequence length="686" mass="71512" checksum="ED8E58FA026EF37C" modified="2025-10-08" version="1">QQQQQQHPSLGVPSDQHPQSSATSSSIPSSSSSSSSSAKPPPSSSSPFSPSVGSHPSSSLSSSHGVTKRTLSPGVQPTPPHNQLSETAGPGHPESPNSCARSLQYSKSLKSSHHPSPHHHPPHHQPPPSPSSSKSPVTVGGPAGYPHHPYSHHPGNAPSNTFPPHHPHPQGLTPGSGAPPLSNGPSPAFSSRGPSPSHAGPYPYPKHPGAPPTGFGAPSPFSPYPPFARPEVVNNSVPGGAAHSGPSPSAGGPSSGPQCNSSSVGGPLTPQSSASLQHNSNSSQPAPPTSVSGGLVAPSSSPFITTTAATAPSSSSSASSSSLISTPLSHHKQQHPQHLYHPHQQQQQQQRPHSNNPYHSSSSTHPHAHPHHRSSSGERHHSGGQNSHSSGYHSNPADQHRATTTTQSASPHDPSRKSATPGQQPPFKTPPNCRQEHLSTSGGGRESSDRDRHHHHPHPHHHHHHHHHRHGSGSSSSSIGHHHSKEHQHQHSRERERERELRDREKEKERVGPSLGSSLPPSSSTFPSPGLSSKGPWGPSTPGPLFSPLLHPHHPSPLAPPLTPGAPPPSSTALPPHSSPLFPVPLAPPPPLLAAAGGGVSLASGMFATPLPPAPLPSLAPTASLPTTHPSASGPFSAESLIRNQQDFLHQDLNNRLLAQRDSAPAIALPPSPFVRSETHQHQHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A660</accession>
    <name>A0ABM1A660_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">12S rRNA N4-methylcytidine (M4C) methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101850829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941577.1">
        <property type="nucleotide sequence ID" value="XM_013086123.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850829"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00006">
        <property type="entry name" value="16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265:SF0">
        <property type="entry name" value="12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="S-ADENOSYL-METHYLTRANSFERASE MRAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012941577.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38185" checksum="0D3552BA57F6C7B5" modified="2025-10-08" version="1">MVNEVLQALQPSDGQVIVDMTFGAGGHAKEILSSSSSIKYIGSDRDPLARRLANRLAAQHRASGNELIPVLGRFSELPTHLSHLGITPGSVDGFLFDLGASSMQFDHAVRGFSISKDGPLDMRMDGHRFPESPTAADVVNTLDPSDLAHILKKYGEESRAREIAHALVEARYAFGNFTRTEQLARVVKSVFNSKAFRHDKLYRQAHVATKTFQALRIFVNNELNELHNGLEVARHFLKPGGRCVVISFHSLEDRIVKRHFHGIDVDQAANLTIHDHFRNANVSFDVDTIKQDYMSRPWRPLSRKVTEPLDEECYRNPRARSAKLRAAVKENYIVAEEQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6G5</accession>
    <name>A0ABM1A6G5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rap guanine nucleotide exchange factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106012665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941734.2">
        <property type="nucleotide sequence ID" value="XM_013086280.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012665"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45161">
        <property type="entry name" value="CYTOSKELETON-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45161:SF2">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="7">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012941734.2"/>
        </source>
    </evidence>
    <sequence length="93" mass="10608" checksum="02F4119248778FFD" modified="2025-10-08" version="1">MATDIAQFVQCLKKPPLSRTDKDLKVIFSYLHGMEALAGVREHALQSLCSMVRYEFHEGNDIIYYQGEVASCWYILLSGSVFIEGSMFLPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8A4</accession>
    <name>A0ABM1A8A4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101846087</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101846087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942744.1">
        <property type="nucleotide sequence ID" value="XM_013087290.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846087"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="290"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942744.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40079" checksum="DDD41B0CBF3850CA" modified="2025-10-08" version="1">MDDFRGSCGKGDYPLLHAINDVLGDEPVSKSAAGRPANMQWRPASKDNGIDRDDEEENDDEGEEEEDEDEETTSPRVHAPRFSGELKEGAKRALRMRFKKLKRRQRWQQKRARAQRRRFRKKEEDEEDEEEEEEEEDSSDEMSSTEVTTPVTTTSDENVLKVRWWPRRRVTKGKKWLPRRRTTTGMTRFSSTHRPRKIWRKRTESSRPRMAQEFGADEEEEHEVTSWQTTPWWQSGNHNLRAAAHPDSAFNARATGKPGLGLQRETTTEYSAPEVEHHDSATQASAAASAVNCRSLGAGTFADPHDCHRFVICLRGDWLDYPPHVMTCPTGTKFDPNLGLCNHADEVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A982</accession>
    <name>A0ABM1A982_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoplasmic protein NCK2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101858130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943236.1">
        <property type="nucleotide sequence ID" value="XM_013087782.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858130"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11766">
        <property type="entry name" value="SH3_Nck_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF14">
        <property type="entry name" value="DREADLOCKS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="373"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012943236.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="52128" checksum="01FEB41161ACE960" modified="2025-10-08" version="1">MDWIRCRIRRRFAGSGRPSKSQEAMGVGGDVHHLHRHHRSGVSSMAEGPQETQLVAKYDYKAENSQELSMRKGDRLVLVDDTKDWWKVRSPDSGREGFVPSNFVKVSKPKASLFSTILKKGGKKKSEGSKQLSSSSCPSPSLNNGDASYRARTNGNNAANTYETFQLGQCMPACAKFLYTAQRPDEISLSKGERIMVIEKSTDGWWRGRKDDGSVGWFPSNYVEEVNSSAGAHNQQDAGNLLYFTAAEAKSQSSPSHSSADIVLALYSFEGKNSGELTCEKGERLEVVVSESDSDWLSVRNSRGETGVVPATYVTPVSSSGEEGSERGTSTSSSNPQSQSQSISSISNTSIAALALAGRKQFQVAGPLADKEWYYGKISRNQCEDILTKFAVDGDFLIRDSESTAGHFTVSLKAPGRNKHFRVKNSSGTLEIGQQKFTNLEDLIEHYKKHPIFKQDTEKLFLVKPFVCPSSQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9L4</accession>
    <name>A0ABM1A9L4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943448.1">
        <property type="nucleotide sequence ID" value="XM_013087994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013116"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943448.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="56526" checksum="DDDC85D01828A4DB" modified="2025-10-08" version="1">MDRETPVVMASVSDQSLATQLRWLHESTAPFTNSPEVRLSKSWNLLAGPDSTRPLAGEIQKAAELEAEPPTRSSSVPQFLHEGGPADEVSSKSYNYNGQELDLPTQQQKSESEAQTSSGQTKTKLSSSCKDLPENLNGLENSLLRDDPRQDAGRFLLDDDMIIIEHEYLADVIRVAPQTSGKEIRRLHTIKEEGGDSGNERKPVQSTTSSSAQKSTRRRLRSQTSFNRLRLSRHPKQQAALKKPVVKATDISKTPRGRKVFRRVAQSILDDIDCNIINVNDFVDDDDDIGDGAYTDDEGEDDNDNRSGIAYGDYRNRNISILRTKAVSPPSIMELQRQMGGQGKLQKPPPIDPAARDSESSKKLAEDAFLRRVGSRILRHRRPPPAPQPGKLCLAKGVADLTHAEVKDGLEGQGKVKLSLLQFDPVYLRGLTPAEVCTCRWIFELTPDSDPDLLLGKGLRMRGSHVGVRYLDDQLRDEHHAYLMFFAFCNRLKSSRVQKKRKAVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA72</accession>
    <name>A0ABM1AA72_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Suppressor protein SRP40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101855978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943810.2">
        <property type="nucleotide sequence ID" value="XM_013088356.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855978"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045034929" evidence="2">
        <location>
            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943810.2"/>
        </source>
    </evidence>
    <sequence length="321" mass="34481" checksum="356E838FC4D3223E" modified="2025-10-08" version="1">MLLSNAACVLLASAFLFHVVWGNMVIYNDNSPEPEDTETLLEFEQLLVVPELTSAKQHPPTAFKDSSAKQQHQPTSLKDNTAKQYSPAASEDNSAKQQLSAVPEDESIKEHSPAAPDDESTKQISSTVAKDNSAKQLPATVTKDNSAKQLPPTVTKDNSRTRLPDVMFVEDNSTRPSAPHGQSINYSQLDVLLDDPVLHLPDEKRKIAERKAKPKKEAETSSSSSSSSSSSSSSSSSSSSSSSSSSSSLSETAAEIEPELLFNPGSSLDFDGVRQLSAALPVVDLDDFFSDGPLWREKRQTSQGGDDDMVEGCGSSEGKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAU6</accession>
    <name>A0ABM1AAU6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructokinase</fullName>
            <ecNumber evidence="4">2.7.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC106011007</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012944163.1">
        <property type="nucleotide sequence ID" value="XM_013088709.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011007"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="14">
        <location>
            <begin position="2"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012944163.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22562" checksum="4F61CE38FBF22F69" modified="2025-10-08" version="1">MDFKERWGRLKAAQNLIQHHITNLIAIGGDGSLTGANCFRQEWPSLLKELVDKNLVGKEKQVSCAHLNIVGLVGSIDNDFCGTDLTIGVDSALHRIVDAIDDIMTTAVSHKRAFVLEIMGRMCGFLPLVAGIATEASAIFIPEDPPWGDWKQYICDLLTERLESGEKRRTHIVLVAEGAADRKGNPIKCTDVQKTFIKQISLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABD9</accession>
    <name>A0ABM1ABD9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101857837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944461.1">
        <property type="nucleotide sequence ID" value="XM_013089007.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857837"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="696"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="10">
        <location>
            <begin position="815"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012944461.1"/>
        </source>
    </evidence>
    <sequence length="926" mass="102477" checksum="4FEC9A0A273BEDCF" modified="2025-10-08" version="1">MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFADVVNCMQTDNLELKKLVYLYLMNYAKTQPDVAIISVNTFVRDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLEALKDLLSDSNPMVVANAVAAISEILEASSTAQPYLEMNSGTINKLLTALNECTEWGQVFILDSISNYNPKDEKEAQSICERVTPRLAHANAAVVLSAVKVVMKYMEMLNVQGDYVATLVKKLSPPLVTLLSAEPEIQYVALRNINLIVQKRSDILKTEMKVFFVKYNDPIYVKLEKLDIMIRLTNQGNIAQVLAELKEYATEVDVDFVRKSVRAIGRCAIKVEEAAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNQYESIIATLCENLDTLDEPEARASMIWIIGEYAERIDNADELLESFLEGFQDENTQVQLQLLTAIVKLFLKRPTDTQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPGAAKEVVLAEKPLISEETDLIEPTLLDELICHIASLASVYHKPPNAFVEGRGVLRKSLPRNQSGETPGAEPVADTSAPAVPQPTVIPGADSLIGDLLDMGGPTAYQQQQIMSQVQPSPAPAAAVDLLGEGLDNLLGGGGTGMDTLGGLSDIFGSAAQSSSYVPPQEVWLAASKGKGMEVTGTYARRNKQIFMELTVTNKAMQPIMGFAIQFNKNSFGIQPASPLAIQSPLPPNQSASTSLALNTQGQIQKMDPLSTLQVAMKNNIGVFYFSCQIPLHILFSEEGEMDKKDFLASWKEIPSQNEVQSTITNVQHNADTVSQKLRNNNIFTIAKRNVEGQDMLYQSLALTNGIKVLAELKIQPGMTSFTLSLKSRVQDIYSFIQQAFDTILHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABL7</accession>
    <name>A0ABM1ABL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101847770</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944583.1">
        <property type="nucleotide sequence ID" value="XM_013089129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847770"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF28">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="254"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944583.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39202" checksum="0D2E840CF34F59FB" modified="2025-10-08" version="1">MMQNEILDCIYEVYIEDMKEKLHAARYVAVEVDDTTDVTCKSQFAIILRYVENCAPVERFFKFVEVHDRTGSGLAQVILDELAPYDLQNKLIAQSYDGSTVMSGDTGVQTIFQSRQTTGIGLKNAIISDFISAIVRVRGNLSLNMEKEEAVGKRRRITTPFEDACEVCDILTTQLPDWLERSDLHLALSVVDPKQFKKLRTIPSTKIDTIVQNYPDINRHFLETEIEVLYSNESFQSEHTSTVTKLFTFLNQSELTGEFQEVGKVLEILLATPVHTAEPERSFSTLKRIKSFARNATSQDKLNALAVLSVYKDIITKDPQFNEKVISKFALQENRRAQFMYKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE86</accession>
    <name>A0ABM1AE86_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101857304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946001.1">
        <property type="nucleotide sequence ID" value="XM_013090547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857304"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Bromo_TFIID"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="1.10.1100.10">
        <property type="entry name" value="TAFII-230 TBP-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bromodomain"/>
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    <dbReference type="InterPro" id="IPR018359">
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        <property type="entry name" value="TAF1"/>
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        <property type="entry name" value="TAF1_HAT_dom"/>
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    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
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        <property type="entry name" value="BROMODOMAIN"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1445"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="1567"/>
            <end position="1637"/>
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            <begin position="1"/>
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            <begin position="103"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1756"/>
            <end position="1924"/>
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            <begin position="1640"/>
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            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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            <begin position="12"/>
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        </location>
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            <begin position="144"/>
            <end position="153"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="165"/>
            <end position="175"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
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            <begin position="266"/>
            <end position="307"/>
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            <begin position="350"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="PROSITE" id="PS50014"/>
        </source>
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            <dbReference type="RefSeq" id="XP_012946001.1"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEC4</accession>
    <name>A0ABM1AEC4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kinesin-like protein KIF14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101859378</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946062.2">
        <property type="nucleotide sequence ID" value="XM_013090608.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859378"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22707">
        <property type="entry name" value="FHA_KIF14"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
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        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
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        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF5">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="334"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="795"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="729"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="890"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="423"/>
            <end position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012946062.2"/>
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    </evidence>
    <sequence length="1101" mass="120665" checksum="48483413E62C7BF2" modified="2025-10-08" version="1">MASNSPRKPVKGKRALPSVPPPESPRLRSVTFNDEIIETSIGGTQTVGKIKQDVLLHFDAPVTIGNLPAKLADKNSAQKPAQSSASVKVVPSSAVVGKENKGLAEVTATANERLSTEDAAAKVPANSNNKNSNTSATGKGKGSPRKAVRNSGPASNTSSPLGASGARNSLNNGNNTRSKPGKNLSSSSAESDSGVSSGSETHKSGVRLSQPATDNAASTGGKPVPSSSAHSQADKGPTPKPASHKVSFDLEKPAPIPAAVEEERRSTLECIDTVSQSPFRTPTSKQSRRHTLESRIFATPDCYHDVSFGTPRRMLPMIQDESMDAAEDGEDSCSIMVAVRVRPFSQRELSDSNTRCVVSMLNNETTVRSDNGSVHQFAYDFSFWSHDQGSGDFCDQALVYSRLAQPLLGKAFEGYNTCLFAYGQTGSGKSYCIMGHGAETGIIPRFCEELFARADTLASKNKVKVNVEISFFEIYNEKIHDLLAGSKEKGAKKATLKVREHPVLGPYVEGLSTYVVNSFVDVEGWITLGNKNRATAATGMNDKSSRSHSVFTIVLTQTKTESIEGQEHDHSVNSKINLVDLAGSERQSLANTSGERLREGANINKSLLTLGKVISLLSERSVTKKRKIFIPYRDSVLTWLLKESLGGNSKTAMIATVSPASQHVEETLSTLRYAQQARSIVNVVRINEDPKAKIIRQLRAEIERLRAEQGGVMTDEALASSVAEIGRLRQEMEEMSRSWQERLRQAEERKAEELQLLERAGITFKVDNRLPNLVNLNEDPQLSEMLLYVIKDGETRVGRRIDAARHDIQLTGALIADNHCVINSARGVVEVTPIGDAPTYVNGDLVSDKTVLHHGDRVILGGDHYFRFNHPIEVSKNKGDARPGSDVKDFDFAKQELHRVQEARLQAELEGELEKTRQELTQQKHGYEDKLKGLETVLNKVEQTHKEAQSTIHTLKKQNMMLEQEVLAGRKRQRQESSQPTALDEPSFAKSRILELLEAEKKQVAQRLEKLRAKRSEMSTPAQLTALHEGPANMAAGSPSSRRDLYKVALLLREANKINQYLATNLVFSREDVSDEECGGTCRTQIRVVNTRHGMFTLWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEG9</accession>
    <name>A0ABM1AEG9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013878</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946132.1">
        <property type="nucleotide sequence ID" value="XM_013090678.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013878"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946132.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47438" checksum="FB0C6DFE951D9BF2" modified="2025-10-08" version="1">MSGRCELLYGMRHVRLVRIDHSDIYLENERLGEDLVRNLDVLRRDRYRQVMAREAEILHLKQTAGLTSPEDNEDGQGQGQGQGQGQGEGQPKSQVVRVRRVGVFGQNPTAAAVNFVTSENSDPQHHHPGHTPGHAHGPSPVTSDPVYAGRVRAIDVQLPNADENIVDNDEEEENRRRRGETHGQRLLKHFDLDSEPDSDVVVAATSGPFGRNNFRQQNQNNMSRRGRRKNSVGTPGTPGTPGQQVPGKPLGLLENLMDNMKLEKYPDHWYTQVLEASDISYRRRVGSARSLSSPRSTPMFTRTSHTRAGRPQTSIGSGSAERSASAGTSGRAGEKVSIVPPPPVTFSTVVCQGHPTSKTRRQLLEIVNREHAEEEDLYSRSSVARCLRLNRERTRVLQEKVNDFVKSLEDLEKARKRGKGILDQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF32</accession>
    <name>A0ABM1AF32_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101852822</fullName>
        </submittedName>
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        <name evidence="10" type="primary">LOC101852822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946454.2">
        <property type="nucleotide sequence ID" value="XM_013091000.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852822"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="166"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="852"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1097"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1180"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1347"/>
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        </location>
    </feature>
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        <location>
            <begin position="1389"/>
            <end position="1412"/>
        </location>
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            <begin position="67"/>
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        </location>
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            <begin position="95"/>
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        </location>
    </feature>
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        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
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        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
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        <location>
            <begin position="516"/>
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    </feature>
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        <location>
            <begin position="551"/>
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            <begin position="666"/>
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        <location>
            <begin position="695"/>
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    </feature>
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        <location>
            <begin position="725"/>
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        <location>
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        <location>
            <begin position="1097"/>
            <end position="1121"/>
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        <location>
            <begin position="1217"/>
            <end position="1234"/>
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        <location>
            <begin position="1260"/>
            <end position="1270"/>
        </location>
    </feature>
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        <location>
            <begin position="1271"/>
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    </feature>
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        <location>
            <begin position="1354"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1389"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012946454.2"/>
        </source>
    </evidence>
    <sequence length="1412" mass="155676" checksum="D5794D60B81BF1BC" modified="2025-10-08" version="1">MTFVVTEAEDKMSRSGKNPGMVASGVHLSARERRRQKQAGKLWSTHPRKWLLTNEVPEESAPGSCLGNDSPQELTKATDQTPPVAGANPPFLASSGFSHSENDAGSRSTSKTLLSPRKVELTFAGEDRKNSTHLRQSIRLIKSELGKVHHIEGARKAELERRELIFSEKDVLGEGSFSQVFKGTYRGSDVAIKRLRAPLLSVDKNYFTAEVSMLQELRHPHVVMLLGVCSGDKLPLMVLEFMARGNLHSLLHDATRADLSQEEYCQIGHDVTAGMLYLHLHQPPVLHLDLKSCNVLIGYGTRAKVADFGFSKLKHEADVKVSRASRLEPSQATPAWMAPELLAAGEITPKADVYSFGIILWEMLTRQIPYEGLSIYQVLESVRLNRRPVVPASCPTVLSHLMRKCWEHNPAARPSFKDVLRTLGRLPSAEGWKTKTVGLEGDEQGRAAGAERRNTLEVTQRTPVGDWSLQVESVSSDEEDGDSDDDDDDDGDDDESSGEGSSCGGDDRGENEFDSPESSNHQDSSLSPEKKEATSSRRRSPQTQMLPEESFSDKVKDEKTSASAEETVKRLSVVLPTESLAEDEQEVVFGDHCWRQESVHDAEQIPSPDERQSNRPSRRTDTAAKLIEKYLPATKLGSALSKSCDLHPQGQTDRRYSSDKLLPLRHSMDRPKPEVPPRKDDGPVRRQGPDTSAHSCHEISETRSKDFHSDLPSKDATTTSLSDDVDPRSSFKDGSDKGEITSYVPSFLKDKPTPSPRMSIAPTPQDTTNWGKTVNRSLDLPMLSSFMKSLDKAEGKPTMRSADVSHKARFLAKSGTGQRTSVSQVAGFEEEDHRSSYLTQVSEEFKSCEPIPSLKKQVNNNRQTHNRQTHDRQTHNRQTHDRQTQHELDNVEQTRLDCSLHKTFLESPLETSESEKRFPFLSELLVAAAKRTDENADLASGSSISRVTNPDFGKSERQNVLLSSDSSNHSELLLRDKSEHQRISLSTDSSTPSEQLKALVLSSDSSGDTTKCQDKDCEKAISDPVLHGPEDTLPSRPRRLSADSDSDSSTEVDNLSVDSLSLSTDEVDFSVVRGPGADHSAATVLADISSSLSQATSAKGIQNKSNTENIPQLSSKSMCKSNNDRHQFANRESFYLLESHNEDPPFVIESPQSVNSSHVKETSPNQQFVGADSVMCHRPGVDFGLTGHDGESQQDSGNEAGRNDSFSTSQVVGKNVDGIHKSTNGDDKFERDSLEEGPEMVQHQVNKTAGKELSRKQLVKNKMNSQSSSKNSEKNVYDRKSPWSATVNRVPIPKLQFSAADIISQKGKLSKAKELAPHVQRGANSGPPPGAHFSLRASMLLAQKGQLRPVVSREPTSPTKLLERSQQGSVPSVASILKRAMTDRRFAMGDNLDSHDVTPDASWSLQDEELPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQC0</accession>
    <name>A0ABM1VQC0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tumor protein p53-inducible protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">p53-induced gene 11 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101856250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824612.1">
        <property type="nucleotide sequence ID" value="XM_035968719.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856250"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028266">
        <property type="entry name" value="TP53I11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31584">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31584:SF1">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14936">
        <property type="entry name" value="p53-inducible11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824612.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24201" checksum="CDA17599B072420A" modified="2025-10-08" version="1">MAEFGSNHTVTLKQIKDDRPKHSSGDLHSRLKTRKLLGVGETDDGDIHRSKLSQILGHSDQLYVKLPAGLRVWQVFVALMFTVIGLWALILPSHIFHTTLETPGVELITLPIRLYGGALLSLSIVYWMTLSSQDRDIIRMSLLTCVVYFIIQLVVTTTHLLMSGQPFNRNLLLLLTCRGIFALTSLYFHWTLGQRKYPALRKSASEKCLRKATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQP2</accession>
    <name>A0ABM1VQP2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477420</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824734.1">
        <property type="nucleotide sequence ID" value="XM_035968841.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477420"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035824734.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15911" checksum="E3F6B522C40DB2BA" modified="2025-10-08" version="1">MFISDRTKPGKTEIRPDADFFHLSHSLNTRDLRHNDPYVASTKEGLPARMQYKPAKGGNPFSTSVMKDDYSDLNRRSYTQAQVRMLEQDNKLASKMIENSHFFHTDNSGMNQFRSVTMHDFVQPDEMTGGKFNPDFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTJ4</accession>
    <name>A0ABM1VTJ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC101863671 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101863671</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098687.1">
        <property type="nucleotide sequence ID" value="XM_005098630.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825736.1">
        <property type="nucleotide sequence ID" value="XM_035969843.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863671"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16472">
        <property type="entry name" value="RING-H2_RNF38-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="416"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005098687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825736.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="51001" checksum="541F494A399E70BE" modified="2025-10-08" version="1">MDEEEAPSQEAFRNVIIRPNRSDYNNWVSQSRRNDGSNVDGEPPRSNGATSGRTANNGIGQLSNNLSSNMVVSEAGDADGISQPSRRVQNLNSNSSNGSRNSQPVATTRLRHRRGRASGNSESFAGPRTERAQANSVARNSSPTRHTQMRGTRARLVHPRSNNQRAAERNLNPEPELLGSVMISSRPQLERERFISPLSLGEGTDDNPFLLSPGSPDLESEGFDLGSVPLAAGLSDEEFARQLQQEEWEAASSHGHDDLMLPEPRGALGLGQLLSFQNRRPHMLPPIPRGERGARMGPRASNGRRNARGAMSFMNVYPSALPWPFSSSMAEGDDDHMPLVMELFHTNGLLDTDEIESILNPVSEDYEQLLALAEQIGEVNRGLSKSELDKLPTSKHRCDSSEGAEAGAGSADSQQCNICLNDYENGDRKRNLPCKHDFHKDCVDQWLKTNATCPVCRADVKAKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTQ4</accession>
    <name>A0ABM1VTQ4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101864066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035825796.1">
        <property type="nucleotide sequence ID" value="XM_035969903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864066"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044963723" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="35"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035825796.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="62897" checksum="6B4D0364070F56E4" modified="2025-10-08" version="1">MATAWLLQALCTTVLSNGTQQARQAGTNNMFLLANTTSGILRGQLVSGPSVPVARFAGIPYVKPPTVFVSVSGPLRFKAPVAPDSWTGARDALVFGNECLQGTILNDRFRNPNASQSEDCLYLNVYTPTQRPSKAPLPVMVFIHGGGYIIGSGASYDASYLAAKGVVFVTFEYRLDLFGFLSTEDDTLPGNYAMLDQVAALKWVKNNIASFGGDPNMVTIVGQSAGSSCVSLLTMSPLAKGLFHRAIMESGSALSPWAIEFPGNRVTSRILARLISKGVNCNDLNNSTALLSCLQQADANALLKASIGVTGALDANLIHVPRVETTFGFLPDKPSALLSRGQFSHVDTLRGYNSEELGAFIPAFAGSNPKPVTLEVAKQVLRSRLVQFNNLDQEKLQKVMETTFLKDKSSPDVLRREAMDAGDVSAFQGSTVVELEKVVSKAPEKKHYLYLFNHRPSYSKAPQWMSALHGDELQFLFDVRQQMFTDKGNGPPNADDIQVSQQIMERWTNFAKTGNPTSTVPKGGATWNQYRSTTPHYLLINSASQEKVLSQTEMIVFYRKFLDFLEGPSSTPIVPIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VU63</accession>
    <name>A0ABM1VU63_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein lifeguard 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101849932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035825955.1">
        <property type="nucleotide sequence ID" value="XM_035970062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849932"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF127">
        <property type="entry name" value="PROTEIN LIFEGUARD 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035825955.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37907" checksum="679D5636594A4578" modified="2025-10-08" version="1">MAQQSGPPAYNMAQNYPASYDQTQDPYKNAAAGAYGPPPPQSGFAPLPQSGYAPPPQSGYAPPPQPGYAPSHQYGGYGRVSPQAYGSPGTGYSNPTAYDARGSDNSEPAVPKATDDSGMFSAAFSDKAIRRGFIKKVYLILFSQLLVTFGIICLFIFVEPVKNWVQNDGLWFYICAYATFLVLYIALVCCPSVRKKYPGNFICLGIFTLAFSYLTATISSFHDTGIVLMAAGITAAVCLAISIFAMQTKIDFTMCSGLLFVLVMVFFFFGWACLITNLTWGTSHILNCVYGGLAALVFGLFLIYDTQQVMGGRKYELSPEEYIYGALQLYIDVVYIFIIILGFMGKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUA1</accession>
    <name>A0ABM1VUA1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477786</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825993.1">
        <property type="nucleotide sequence ID" value="XM_035970100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477786"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035825993.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14102" checksum="B2E25B6E0A6209D9" modified="2025-10-08" version="1">MDQTEYILFQEVYSGRASSHVGPYKRKEYILCQEICCGRESSPVGAAESKGCSALLPSYHHPGKGPALEYPNRGVSYGPDRVHPVSRGVFWKSVESCRTIQEKRIHLVSRDLLWKRIESCRSSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUL1</accession>
    <name>A0ABM1VUL1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Receptor for retinol uptake STRA6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC118477823</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035826103.1">
        <property type="nucleotide sequence ID" value="XM_035970210.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477823"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF16">
        <property type="entry name" value="RECEPTOR FOR RETINOL UPTAKE STRA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0683">Retinol-binding</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0845">Vitamin A</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035826103.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19694" checksum="5372735F42C0FE64" modified="2025-10-08" version="1">MLVYGMVYFPVFACLSIGSVYGYGLGALYVWMMTVVEILRLFDCDEELETRVAIVLKRLPQVLCLLYLSSCIPGRFIQSVRRKEFFVQAMEEFPHHDSEDLVAQAYYGVHVRSLFKTLKAARVPSSRLHWVKQNLCQLFNQRVYRSRPGFRYSSRMLTTMVVGAVVLYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX11</accession>
    <name>A0ABM1VX11_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101853181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826953.1">
        <property type="nucleotide sequence ID" value="XM_035971060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853181"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF87">
        <property type="entry name" value="COLLAGEN ALPHA-1(VI) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046214269" evidence="1">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826953.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="22699" checksum="557B0F3565E4AA8C" modified="2025-10-08" version="1">MGFSTLNSLKILHHSLTLTVADDIVVVADDSESTRDFLDLTYFYNNDNKAFLSDVVGGTDFSACRIGVLLFSDDVRFLSNLTTNGTQLQSDIDNIQPSDNGFGKTNLADAITEATLLLLDSKATTSKVILVVTDGQPNDVNGAREAAVTARSLGIKIGLVLPPLPDGNIGYRPADMRGILDTVAGDEIQILASRADLTTVLPSSFCPTAGSIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXM3</accession>
    <name>A0ABM1VXM3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microtubule-associated protein futsch</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101848222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827166.1">
        <property type="nucleotide sequence ID" value="XM_035971273.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848222"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1768"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2315"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2576"/>
            <end position="2643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="407"/>
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            <begin position="408"/>
            <end position="423"/>
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            <end position="560"/>
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    </feature>
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            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
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        <location>
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            <begin position="2630"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827166.1"/>
        </source>
    </evidence>
    <sequence length="2694" mass="287713" checksum="F09A793A5933196A" modified="2025-10-08" version="1">MKSKGLVSEGKELNDGEESGFGSSSDSDSDCTDDNNFSYSNIHTTRNDDSMTKTPDGVTTPDGVASPDGATTPDGVVTSDSVATPDGVVTSDSVATPDSDAKPRSQKGDPGETEPNTSGSVLTSPEMASGPSEMVETSLRPMSPLFGGPQPVILKRRSTTNTSDPPRIKVSKQLHLSSSSSPLSESSSDSSSSSSSPPSSTSAPTSGLTSEPAPVQTVIASATTTATTTATATATETATETATATETETAAAPTTASAPEQPSSTSALFSGPQPGTLKRRSTASASKSPRIKVSRQRHLSSSSSSESSESSPPPSATAPEQPSSTAKSSSLPDEINDVAADLRPSQLISPLPSTPSPPPPQASSSPTSSSPPSPTSPPQPSLPERDTHSSSPGTTSSSTPEQPSPTESSPPQPSSVSPPPTSPQQPSLPESDAQSSSPEAAPSTSTEEPSPEQTAQTSESSNSPPRPPTPRLRLPESDAQSLSPDVSPYPSPEQPTQTSEPSNSPPPPRTPRPWLPESDADSSNSESASSSSPAPHSPEQTTQTSTPPISPPAPPTPRPWIPESDTESSSPESAPSTSPAPPPAHTPAPEQTPASALPSSTATSSPSPPWPPQSSLSESDAESSRPDSSNPETTPSDSPATEPTSAQASPSASESASGSGSAKLPAQHAEQLKTLNLTSTPDVLMSRLSQQQTLSQRTPTLSPTSSWVQSSLPSSSGPSPRSSPRSSSRSPLQQSPRSSLQSSGPSPRSPRSSPRSSPRQSPRQSPRQSPRQSPRQSPRQSLRSPQQSQQSPRSSPRLSPRQSPRQSPRQSPRQSLQSSPRSSLRQSLQSPQQSPRSSPRLSPRQSPRQLPRQSSRQSPRQSPRQSPRQSPRQSPRQSLRQSLRPPQQSQQSPGSSPRLSPRQSPRPSPRQSLRSSPRKSPRPSPRQSLRSSPRQSPQQSRQSLRSSPRQSPRQSPRQSLRSSPRQSPRSSPQQLSRPSPRQSPRQSPRQSPRQSPRQSPRQSPRQSQRPLPRSPPSQPSQPESAAQNLSPEDTPSTSPRYQGPPRSPTGSRITFTSSPSSTASSSSPHPDSSSPPATLSSPPTSASPPPATSGLTSASAPASDRPSSTATLSFLPYDINKLMADLRPPQLISPLRSTPSPPPPSPPPPSSSPPQPSSPPPQPSLPGPDSQGSNHEAPSSSSPEQLSPAQLPPISAPQTSPPPPHPPSSSPPQPSLPRLDSQGLSLEDPSSSSPEQPSPAQLPQISAPQTSPPYALPQPPPLQGHDSQNSSPEATPSTSTAPVPPAQPPPTSAPPTSPGPTSPPRREDEPMSTSDEETLSLLSVPTPQISLILPPASPPKSPQPAPQENDFWKTVMAKPSSPPSNNNNNNNNNNNNNNVHDIDNDDDDDDGCGGAGGNGDSKGNDDGNGDGDGDKDGHKCGHKEGYKDLYIDGHIDGDEDSDGDGDGDEDGDEDGDGDGNGDAEDNGDGKGDRDGDADEDERGGKDGDTDGDKGGDGDRDGDGADDGEKGGDGDRDGDGGDDGEKGGDGDGNDYIDSDGDKDGGDNGENESEDDGNGDRDGDENGGKDGDKDGDKGGDGDRDENGGDDGAKDGDGVGDRDRDGHEGNDGERDGNKDGDQKGKGDGHGDKDENEDGNDGYGGDNRKPITKSKSSQKLPKKRTFPGKQPQGTHRNNSEDTTTLSRKRVRAPRRPYISPVRRSPREKKEKQKQPLQRTPIPPKAELFPEKKRNNAFNLEIESLRQQVEYMREIRRQQKEITLKKRWAKGSTDVAKAGKVTEESKLTEESKLTEASKLTEESNITEESKVTETAKVTEESKITEESKVTETAKVTEAGKVTEESKITEESKVTETSKVREAGKVTDTSKVTEAAKEEKAEKIAPATKEKSNITEESKISEESKVIDDSKVTEPAKVTETAESAHEAKTVKIARAAKATQTVKKATDHGKAGKSLKAKSTPGTGSSERSHHSLGPRFKQRAPHPYKDTKHPGHLVKQKQLGRHVVQQQPGHQVKQKQFARNVAQKQQQPGHCVVKQLSEQQVKQQPAHHVVKLLPEHRVEKQLSEQPAKQQQQQQSTRHVVQQQLPGHHVVQELPGHCVVKQLSEQQVKQQPAHHVVQKQQPEHCVVKQLSVQQVKQQQPTRHVVQQQLPGRHVAQQLPGYRVVKKQPVHHMKHQQQSINQVKQQEPVRQTVQKQPGHYVKQQQQLGHHVVKQQQQPRYLVVKQQQQPRYLVVKLQQQPGHQVIQQQQPGHHVIQQQQPGHQVIQQQQPGHQVIQQQQPGHQVIQQHQPGHQVIQQQQPGHQVIQQQPARHVVQKQPARHVVQKQPARHVVQKQPARHVVQKQPGHHVEQQQYGHYAEQQHPDVGHTDKRPVEGKVENLLDAPKTQDETATTVSTFELFLPNDFDEVMKKVREEENNSKTQGGEQPTGVLSPADVYSNISATVGLPKVTRASVINTSTTAGISEGTTVNMAQGAGVQRHFNSPRIGDVGSHTGQSNGNTTVGALNEKRTHIYHYKGSTSTSERAASNMSRSYTSGVSPYNPACRHSNVNHLPRAIQSPSVPNASPMRNFFTKKRTTASATIGSQAASSLSTQGSVSPNNTATADPPSTYNYSPNPVQSRGDLWPGQQQAAPHVAQQSYQQGQQGAHPSNCQVQGSFNIADHVVSSAPIPDDYQPIVSLNLDECSIVDATNAYALCPYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VYQ8</accession>
    <name>A0ABM1VYQ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Neuropeptide FF receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14 15 16 17 18 19 20 21" type="primary">LOC101845712</name>
    </gene>
    <organism evidence="10 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012942001.2">
        <property type="nucleotide sequence ID" value="XM_013086547.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827547.1">
        <property type="nucleotide sequence ID" value="XM_035971654.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827548.1">
        <property type="nucleotide sequence ID" value="XM_035971655.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827549.1">
        <property type="nucleotide sequence ID" value="XM_035971656.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827550.1">
        <property type="nucleotide sequence ID" value="XM_035971657.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827551.1">
        <property type="nucleotide sequence ID" value="XM_035971658.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827552.1">
        <property type="nucleotide sequence ID" value="XM_035971659.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827553.1">
        <property type="nucleotide sequence ID" value="XM_035971660.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827554.1">
        <property type="nucleotide sequence ID" value="XM_035971661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827555.1">
        <property type="nucleotide sequence ID" value="XM_035971662.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827556.1">
        <property type="nucleotide sequence ID" value="XM_035971663.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845712"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="119"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012942001.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035827547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035827548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035827549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035827550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035827551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035827552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035827553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035827554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035827555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035827556.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18800" checksum="2610C46F3EA87CC1" modified="2025-10-08" version="1">MIMNLKTMFRSSSNASYTVDPYDGSFRNLDDNGTSMSAVRVEMISPTNSTFVAGQVTKDSFALNSFDNSSFMNHSNSSSSSSSNNNSTDEYFELVKQPLFMLVILSISYGIVFLLALLGNLSVIAVVARDRSLHTATNFFLVNLAVADMLVAIICLPITLLSNIYTVSFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZZ7</accession>
    <name>A0ABM1VZZ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101853667 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101853667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827990.1">
        <property type="nucleotide sequence ID" value="XM_035972097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853667"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035827990.1"/>
        </source>
    </evidence>
    <sequence length="842" mass="94962" checksum="3F92DB1D98680E86" modified="2025-10-08" version="1">MPKAEGKKKPVQVEEGLRQAFFREREFSAKVAAMEIQQKPANDKFSRLSTFPCTFNLSLPQMITVKRMNLLKKKLPKELEDDNLKEESVQTLNFISWIEYQLNGAESALKWNKKARKIKILDSFGKEMNNIATIANQGYLLLLSHDEIAPLEVIERLEKLPSQDGYQSLRKRALADQAYAYFRMGGVSNLAMSIERYEEAIESQLASPEVHLWKYQLAVVYRRASCGEIFSNLPGNRPLSYYNEGAEKLLRDVAENCLDCTLKGRAFAELVSVNPTDTVSWEKAVECNKKCGDVFLLTTLGKATSTVDPDKAIHVLRESLKIRPTTTAYHNLAICYEKKAKDNLLKTTNCDEQFRKSSKVEQKRMNVVSLQLQREQEILLDKDEEMIAQALKFYKEAQKLEDGEYTPAKYDYGLLLKACGLTEKALKQFNQITSIHSGFLGTTIFAYEEAARCLLILSERAQSSGSCPKYKQLREEAVKKLLQAISTSANIVKGTHAMKSLSEDIWAFLKHTHGGDKVGSSDEAVNIETEKKLLDLMRRVERYGEEMLGVVRNLLKYSEEQLDDENVIVAGLESYLKIQNFDEAIVFLEMCQTRHATLENNLWIKDPLKSLSIRVQLLAAQDKLLGRCGEAIAIFKSLFTSLYKNRSSPDVLVVYDDSNDNESGMSHTSEAASRLQTVMCDLFDLDLSRNLQSCNEYNKTELEVMFQEMVKPRVVVLLLGQEPLDSEFEYLLTLVPQIHIHCAEKGLTQPHVVVATTEKEVNIPPLLGSHPRLCISEILSNLVTKETIKAKDDEADSHLGQDCGFSSSVTNTLMTLFCSLTGNTWPLPEVEKPAVELSGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W123</accession>
    <name>A0ABM1W123_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multidrug resistance-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101853195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828366.1">
        <property type="nucleotide sequence ID" value="XM_035972473.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853195"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18592">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18599">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF447">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="898"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="956"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1055"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1146"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="217"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="568"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="920"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1235"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="799"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035828366.1"/>
        </source>
    </evidence>
    <sequence length="1475" mass="162886" checksum="3FAFD2EF8D9C3177" modified="2025-10-08" version="1">MHGPDECRATSGGSVCSRGTSTDGRPPGIAKNYWLCFCGHAKFTMGDEKEDDRVLRLKNYQGDSSGGGDVSQESRRMEGVAEDCGAVTERIIDRTRKKEGDDDFGACIVRQPDMSRYKDALKSLMPVRLEKEPENTLPLATNGCINYITFGWLTPYMWRVFRKGVDEIRDMRISEKESAQVNAQRMDKFWQEELTQNGPVKASFGKAIFKSFRTRLVIGFFATFVSVFLTLANPIFVIRFFLEYLSEGNVDVSSGIGYAIGLGLIILIQGLIGGFFWTMNFEAAARIKYGSLALLYRKVLHVKSFKDKTTGDIINFISNDGQRIWDGIIMGPFIAGAPVILIISLVYGLVLLGPWALLGWFITIGFFPFALTCAKLSMNFRAAGIQITDRRVGLMNELLTCIKMIKMYAWEKSFSNKISEIRDEERAVLEKSVFTQSIAMGSAMLIPIIASCLTFVGYVGSGNNLTPPEAFTFVSLLNTMQTSLTVVPFSLKSLSELMVTTARIKEILMLDEFEPNSTRVSDDGLAVEVVNATCMWSARKTGKETSAEINGNQKKKKQGKQTEEEESLRPANEEDCNQIYTAPALRGVSFTLKKGEVLGICGHVGCGKSSLINALLGRMDVSAGALAVSGSIAYVSQQSWITNDSVRNNILLYQEYDRCRYNEVMEACALKEDIKSLPAGDITEIGERGATLSGGQKQRISLARAAYSDCDLVLLDDPLSAVDVHVGQHIFEHLIMGVMKGRSVVLVTHQLQYLQKCDSILVMKDGAVVELGHHDELVAADGEYNNLLQLYYNKSEAAKKRESVTSSSSSEGSGPGEDVVDEGKSSDVEVPNGDAGISGDCGSAPVTSSEVETLEITEVPHESGENSPTGQLTEEEEIGTGSLHFTVLKQYIEGMGGYPVFAAVLLCFMLPVVGVTVAGWYLSHWLEQGGGGSNMTIGNLTKPSKRVIDHPDRDEYLTIYALFIPILIITMLLRSATLTKVVLKASSYLHDKGFLRVLRWPLSFFDSTPIGRIVNRFSADQDEIDMRLPMNVEIFVTNILQVIAGMAMISYVSPWFLIAVIPIGALFFFLVFLFHTCVTIMKRLDNVTRSPVISHMGASVQGLTSIQAYNKTGLFVQKHCELLNANSVAVFLYYAANRWLAVRMDAVSAFVAFITGLLILVTYDHLNPALAGLALSYSVQMSGLFQFTARFFIEVEARFTSVQRILKYCNITDQESSSATADIVPSSYWPTSGGIAFDRVSLRYRDSLPLALNDVSFIVEPQEKIGIVGRTGAGKSSLTTALFKVVELQSGCVRIDDMDISKIGVDSLRSKLTIIPQDPVLFSGTVRYNLDPFQQFTDADIWEVLRKCHMVDMIKMLEHQLDTLVEEGGLNFSVGEKQMLCMARALLRNSKILVLDEATAAIDTETDALIQKTLQESFSKCTMLIIAHRLNTITHCDKILVMEDGKVQEFDTPQHLMENPDSKFKKLLDASAKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W134</accession>
    <name>A0ABM1W134_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC118478591</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118478591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828377.1">
        <property type="nucleotide sequence ID" value="XM_035972484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478591"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828377.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20694" checksum="A59845F41E2B2081" modified="2025-10-08" version="1">MIFASSLLGREIQQRWTNLRRCFLWELREQKKSRSEQAAKRRRKYIYFDQLLFLLPTIEQRGTVSNSQPYEDEIIAEPTETTEPPGDVAKEPLASTSAACNTAPKTFKRKHSSSDTSYEQKLLDILRERADKVEEIDEDKSFLLSFLPAVRRMSSEAKFKAKLEVLKIMHKFELSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4A9</accession>
    <name>A0ABM1W4A9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118479038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829502.1">
        <property type="nucleotide sequence ID" value="XM_035973609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118479038"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829502.1"/>
        </source>
    </evidence>
    <sequence length="1449" mass="157632" checksum="5747721004DC0DC7" modified="2025-10-08" version="1">MVLCDAVAVLSSMSVVEGGAEMVRCGSVYVTPSDHAHKVTQAVLSAPNVHEKKRRASKYTVAIGTTHGHVCTQSPRSGDNGSTVSEIYTSEPRVRMAGAAPSAHHHQNHAKTFGQHSAKKSQGSSRPAAFVPIPELGIYTPDQHVLQNGTYAQHCHSREVNNNKRNRHEHPTAGSDTNSLNNAASTVTSNGNSSFNSSFDESVKSYEYGGKGGLKRLDAWNGRGLHSNYPSSDVYHSCMDISTTQRDERDFGTMNSTRSYEPEYKTIREEDNSEVTDANRTMDPANRSHSLGDLTSGLAFSLVGQKKSESVASVGDPSGQRSSRDGEQNGSGKKSSEGSSALKHIRERLQRAVLNSQSRKTTPSNVNGKEKHEILSGNMGTTVLPSGRRDHTDSALNSRVETTFSAQCPSGVTQQNRCVSQSQQHYQQYQPQQQSGPPPSVRERVSLMQRQQSAPQPEPSASSPPLSLSRRRRDSEETTSSFKSALSDYASVKRPSNDRLAPSNLNNNSNYSNYGSSDRLNNNNNNNSSSSSNNQSSRSQSTLVNSYSSSTGYSTVVSQDTLRESYPDTQSAPNTSRTSSPSKPKRSLPHVPTSETSERIKRFTEMMKSRITGQGGSTGSAGSNSSSGSNGPQGGGFTPPIRMSSVDSGASDRSVVSRKSSAETPSDYEVSHINNNGGKPRRHERGPKHSDHSDSGGTKHQLQSQMHKIPETVVSNDVFYPQNSKEVEPFSHGNGFGPAHVSSPKVVNGGADKRRFSDNGPGFHESTRGNLSSNFSNGPYAKTHPYGYSIQGDTHDAYVPAQASHVTSEETPLPPGDRSTDSGQTTGTNHSYNGSALDSGYTTNNDGENDSVNLDHQRPPPRHQSNLANSHRFGSVQNVSSAQAHGNPRDGNLFRHNPYLQDDRFPNSKPAPVDHHRPDVGPYSAREYPNKYNNNSADHGSGVPPVSIKSELLPVTRQLSQSNDVNKYRSTNRRSWDYSDVGPDNSLVIENGMRRNNKFEHRYRSTEVMPSYQYSKDVSNFGAVHTSNQFYPRHEHEDRYPNSNNQHVANGNLSSNSNFRSVAADQRPQHASSSTSQSYNANLDRGDSAGNGVAFFQFPNNTPQRSDRTTALTNLPANQQSTSLKPIARGSEDQSPHSSNDQWNADMYRKQQSSQTPPSASSSTEGVRQRPVPLSRSNRQARGRTLPGGFRLNESDSSSGHVTNPNLEISLFHMTQKYDLCPLLLNLPKHVSLRELVNLKEVSLEISLSGVPGYPGSPQGQTPKIGSPGSAFTPVGSLPDQDQPLVAKVKVVCFSQVWDEVHKHTTLGRVLESDILVEVNGWFCLGADTTYLTRIVETCQGAITVTVARLKESDEKRYKGQTPAERIKGLETEISRLDNLIQHKDSKIKEMSSGSTSSFSGAGSSIQLTTSSSSTSSHGVKRRQTPVISSVNGEPPCEGMVIGDDEYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4P2</accession>
    <name>A0ABM1W4P2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium/calmodulin-dependent protein kinase type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829635.1">
        <property type="nucleotide sequence ID" value="XM_035973742.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853061"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829635.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30872" checksum="8BD005F201499C17" modified="2025-10-08" version="1">MDAVEQYDAFFNSFNLVRGPCLGSGAVGEVVLASAKHNSSLKVAVKIVTFETEGCKGDFLSEVGFLRDLRHPRILKMIAFAMDDHQGFMLSTYFKNGTLRDIMSSDHPVEEPRILRHILDVASALQYIHGLHIFHQDVKPRNILLDDQDRAVLADFGIARQASDSSAMVMKWRTTPGYSGPETRKRRPMSPFKLDMYSLGVSMWMLIYRQRSVGIKDLLAFSDQCKDVKEPYRRILRQLLRKNPTKRWSAADLLRFCVWNSLCAPSLMSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q4PKP7</accession>
    <name>Q4PKP7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 13">Importin beta 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100533387</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2005-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Moccia R."/>
                <person name="Martin K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DQ072162">
        <property type="protein sequence ID" value="AAY81965.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191603.1">
        <property type="nucleotide sequence ID" value="NM_001204674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4PKP7"/>
    <dbReference type="GeneID" id="100533387"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="409"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAY81965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="NP_001191603.1"/>
        </source>
    </evidence>
    <sequence length="878" mass="98092" checksum="7C0679D26E359956" modified="2005-07-19" version="1">MDLIKILEKTVSPDTNELESAQQFLETAAAQNLPELLKQLSDILKHGGNSPVARMQAGLQLKNTLYSKDQTIKAQYQQRWLSFPEDVRNHVKQNVLATLGTETVRPSSAAQCVAYIACAELPHKLWPDLIVNCTRNVINPASTEMMKESTLDAVGYICQDIDPEILQPQSNDILTAIVHAMKKEEPSNHVRLAATNALLNSLEFTKDNFEKETERHLIMQVVCEATQSTDVRVRVAAMQCLVKIMSLFYIYMTHYMGPALFAITIDAMEHENDEIALQGIEFWSTVCDEEVDLAIELSEAAEQGRPPERTSMFYAKGALQYLVPILLVSLTKQEEFDDDDEWNPCKAAGVCLMLLATCCEDDVVQHVLPFVRDNIRHEDWRYRDAAVMAFGSVLEGPDPEKMKPIVEQAMPMLIELLKDPSVVVRDTAAWTVGRVCEILPNSVLHEACLHPLLNALVEGLVAEPRVASNVCWAFSSLAEAAYDNAEQPDDGSEPETYCLSNYFETIVERLLQTAERTDGNQHNLRNAAYEALMELVKNSPKNCYVIVQKTTMTILERLERVLSMESAIQSTNDRVQYNDLQSLLCATLQSVLRKVTPEDAPKISDQIMTALLRMFQSTTGKAGGVQEDALLAMSTLIEVLGDKFQKYMDAFKPYLLLGLKNFAEYQVCLAAVGIVGDLCRALGQNVRPHCDELMMMLLENLGNDSVHRSVKPQILSVFGDIALAIGMNFKHYLDVVMTTLQQASQAQVDKTDYDMIDYLNELRRGCLEAYTGIVQGFEGRCDTPSSDVVLIQPHVNHIVSFIEHISVDDDKSDSNVAACCGLIGDLCSAFSHQMLPMVDRDTITNLLTQGRRSKMQKAKTLATWATKEIRRLKNATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAQ3</accession>
    <name>A0ABM0JAQ3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 93</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101860059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC93 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089338.2">
        <property type="nucleotide sequence ID" value="XM_005089281.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860059"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039116">
        <property type="entry name" value="CCDC93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019159">
        <property type="entry name" value="CCDC93_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048747">
        <property type="entry name" value="CCDC93_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16441:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16441">
        <property type="entry name" value="FIDIPIDINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09762">
        <property type="entry name" value="CCDC93_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21673">
        <property type="entry name" value="CCDC93_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC93 N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC93 coiled-coil" evidence="6">
        <location>
            <begin position="191"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="302"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089338.2"/>
        </source>
    </evidence>
    <sequence length="631" mass="72776" checksum="9DD607226433CF28" modified="2025-10-08" version="1">MAAATGSIFAGRLRAGSEKYASVDADGNPIEVETREDEEQNVKLQQTIDLLLAAGYFRARIKGLSPFDKVVGGMTWCITTCNFDVDVDLLFQENSTIGQKISLTESIVAVLPRMKCPHRIEPHQIQGLDFIHIFPVVQWLVKKAIETREEMGDYIRQYSISQFNKNHKMPEDEAFEAVKDNATTTVLDVKDAYRPQRRYRRHDADSLTDEEMRVQSTLLEYGRQYGVSKSDKEEKDSDKAAKKKAIAAGLSKEPQDNEEELQAEEERRIKALMSGMSAMGAQEGKVTASAVGSIVGMQSQEIQKMASEYAQKQAEIEQMEKQERQGGAQQHQRLTAALKKQIEQQKEKLEDLTSKHNQLHETYVATQQKLEEVQQQSADMEAEMERMTEIEQGENQGILQNLRSLVAMNENLKQQEQEFKAHCKEEMARLKKNIEKLKEEADAVDGEDKERVNLIDKQYTADKEKLHKIRLLLAKKNREIAGLQRKIDEVPSRAELSQYQRRFVELYNQVSSKHTETKQFFTLYNTLDDTKAYLSKEVQLLNSIHDNFQQAMASPANREVFLKQFEQMVDGVKQNKARAEKKRQEEKMKRDQLSDHHLDLIEKQRLYFKTVKDFKEECRKNEILLSKLRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAQ9</accession>
    <name>A0ABM0JAQ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847004</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089366.1">
        <property type="nucleotide sequence ID" value="XM_005089309.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847004"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005089366.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31487" checksum="E170832435C5F976" modified="2025-10-08" version="1">METETIHLSLLVDLYRNQPCLWDSTSPEHANKHLRQKALEEILKDAGYPVTEDNVTVLKRKINSLRTTYVRELRKVLDSQEKDPTNVYRPRWLYFDSLDEFLNTITWRQKGSAPLNFSRSENSDGSTPPVRRAMKRTSTREAESGDGESSCSSFSDFDSPPSPRSAKSRSYSSTKRTSQSPNRSSSLSEEQGPGKRTKLDPKMDNYLVDIAREKESYATMVKDLKQIKNSMTSAAPESRWTHFGHYVAMTLDTLDPVVATAAATEMQGTIAKFVAEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBF5</accession>
    <name>A0ABM0JBF5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 28 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101861089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089805.1">
        <property type="nucleotide sequence ID" value="XM_005089748.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861089"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="8">
        <location>
            <begin position="215"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="10">
        <location>
            <begin position="296"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="9">
        <location>
            <begin position="398"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005089805.1"/>
        </source>
    </evidence>
    <sequence length="649" mass="70693" checksum="F6CC4EB559192833" modified="2025-10-08" version="1">MQRNIGTLFLLKKKSQIIITTSFIAICVASFESLLRYQNMKGNTRNSYDVEAGGDKSVHAEEMVDMVGLEDGAERSHTEDMQPTKVTSVLLGCRQNVISCCSTHKRAVSNVLQLLFFIGLCVYLGFAFHHSFGDEQSVTLLAVSCVLTVACLYSKLSPNVGMAARKACSSISSPFSPKTKSRIYWIALSLMMTSLVLYVLVDTALSRPRNLISALGVLVFVALMFCLSKDPGKVRWRPVVWGLLLQFVFGLLVLRTRWGYASFQWLADRVTEYLDHTDKGTSFVFGKSYGDHFFAFRVMSTIIVFSSTISVLYHLGAMQIAIDAITHIIRVSLGTGPMETLHAAFNIFVGWAETIPVVKPLLDQMTKSELHAIMTNGFSTVSGGAMAAYILYGAPANHLISASFMSAPAALAMGKLFYPENVPGRRKQKAPVIPRSTSGVIEAASAGAVSAIPLIAYILVHAIAFLSILDFINDTLAWLGARVGIAPPNYPVLSFQFISSYLLWPVAFLMGVVPDDCRVVARMLGVKVFVNEFLAFEDLGKVRSNNVALLNYTTVLPNATWSWTQTDDVILDMSGLVLKGGVMSERSATIATYALCGFSDLLALGMMVGALTAVTSHRKRDVIDVAPRALFSGVMACFLTAAMSGLLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBQ4</accession>
    <name>A0ABM0JBQ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450 2U1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089995.2">
        <property type="nucleotide sequence ID" value="XM_005089938.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860780"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005089995.2"/>
        </source>
    </evidence>
    <sequence length="342" mass="38227" checksum="CC34B3C768C24A28" modified="2025-10-08" version="1">MLESLKGKPSDVRVMTSVSVANVLSQSLIGQRFEPDDPKLQKLFTLMNEVVGKLEGASLVHFFPFLKYAPGDPFGAKALEAKAKEIKDIFSSFVQQHDEDKSKDSNDASIDNVVAAYNYEKKRKLEAGGMTMLDDENLVKTLLDMFMIGFDTVNTTIAWCLLYILHHPDVQEKIFREIEAEVGPHRLPSLHDKNSLPYLSAVIMETQRLGSVLPLNIPRKCNTETEVLGYKIPKGATVIPNLDSVLSDPEVWGDDANLFRPERFIDASGKLVQKEELIPYSMGRRGCPGEAFANMQLFIFLAVLFQRFRFLPADAKNLPTLKGFLGTSNAPSPYDVRVISRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBT7</accession>
    <name>A0ABM0JBT7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101853424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090055.1">
        <property type="nucleotide sequence ID" value="XM_005089998.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853424"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005090055.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="22771" checksum="42FD83760489D4FD" modified="2025-10-08" version="1">MSSAGPGKEDKNKKDADAVTSTVTEVHSANSWETADLGDSQRHQKFLRLMGASKKEHHGRFVIGDNSSSQTRTKNDTGQLNEELVEQYEQSMEHRLAGGRRGHLGLGYHPDDNEEKKENDEEKKQKDEEVREVRGEADGAADSDSGKDSIGSGSDEDSNGKTEKKEGESAASKHKDESSGDGGDRKRESSDKSSDTQEKKLKFVKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC93</accession>
    <name>A0ABM0JC93_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FMRFamide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101845594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090366.1">
        <property type="nucleotide sequence ID" value="XM_005090309.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845594"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005090366.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37813" checksum="F75E1E48C121619C" modified="2025-10-08" version="1">MNSTGSSGPHPLEGEPGYDLMMTGEVINKYYMWVIFAFGFPANVATIVTICHMRHLGSFVMYVALLAVMDNLAIVIKIVFYQLLLNKVNIATAGCRALEFLGNFLITYCNWLLVLMAIERLMAVRYPFRIHFQSCLTRQKAGVISAIVGGVIAGMYLPILWASTYRKNGQSVECQKDDLDLLQAIHWTSMAMYAFIPFIILVICNALIAREIRMSFRLRSAFRSINTFISTRHCDIPVQRQIMLMLFSTTFMFLLLHFPICVFVVATYWPVSGPQAYAIKYFCQQLAYLLCDSNHALNFYIYFLSARKFRKHFKYVITCMFCDRSVAAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCT9</accession>
    <name>A0ABM0JCT9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101853432 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090749.1">
        <property type="nucleotide sequence ID" value="XM_005090692.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853432"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090749.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47916" checksum="E60F09351D8F29F7" modified="2025-10-08" version="1">MMTSDSQPQIVGCQSGVQEPVYQATPKTRFAHCYLRSRLGKSPLQSSSRPGRSPVQSGTSDRRTPDVVVKTSTRIFSNGKEENVISGNHYDVTSSSLCTPPPWRYTGVGSISTVASFVDDKVSPGLARLRMTPGAMREKQRQLIRKHNAIRKRSDQLQTGGGVSLWPNMKEMRLSKSEVVKLSLQAVALCIFTKLILQTLHGDSFQKLQNYTTLVQTFCTNNSILRTTNEEQLRTQVLLWHTGLLELTNQVQSYFNMPVTTSSYQLYIFSYLIGLGVLVYYLLDNILAKNKLTPSRIRKWTCLLIVIGTWTVVMAHGLLLAYSLEKQVVKCVQKYSDSLSHLVTVPIDLNIFHNVLLYWRARFLDNASHGLLLVLDVISVGDIIFYLQYYSVPIITVLVCPIVKLVSACWTVHGQGEYLCSKNVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEB5</accession>
    <name>A0ABM0JEB5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hyphally regulated cell wall protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101861184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091762.1">
        <property type="nucleotide sequence ID" value="XM_005091705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861184"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005091762.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="24770" checksum="C6388AB43927DBBB" modified="2025-10-08" version="1">MKLEGGNASVSMVNSFLPKEDGSVSMVNSFLLKEDRSVSLVNSFLPKEDGFVSLVNSFLLKEDGSVSLVNSVLPKEDGSVSMVNSFLPKEDGSVSLVNSFLPKEDGSVSLVNSFLSKEDGSVSMINSFLPKEDGSVFLINSFLPKEDGSVSMVNSFLSKEDGSVSLVNSFLSKEDGSVSLINSFLSKEDGSVSLVNSFLSKEDGSVSLVNSFLPKEDGSVSLVNSFLPKEDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHK4</accession>
    <name>A0ABM0JHK4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tryptase beta-2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101852309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005093819.1">
        <property type="nucleotide sequence ID" value="XM_005093762.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852309"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045510788" evidence="9">
        <location>
            <begin position="28"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="33"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093819.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="35448" checksum="79036C48EBCC1318" modified="2025-10-08" version="1">MRLPRASWFRMFTFCTVAFFLSPPSQAARVRRVVGGRELAAGAWPWLVSLNYKEHHVYLELQGLRHLCGGTLVHPQWVLTAAHCVHFASGSAGLGVAENWDAVLGEYNRRVNEGHEQRIQVDAIFVSPSYSLSPKLTGDIALLKLATPVNITDSVRPIGIDTLREIPAGTSCKAAGWGQHAPDDYGQPQYGNGTIVPHVIDVKRVSTADCRRAYAKFWPLIDQRVMCFNSNTRSDTCKGDSGGPLVCRDGQGQLQVTGIVSVGMGCALVDFPGIYTRVAEYRPWILETIETHSNWGMAGDEGDAGRQAEQDEAENQAQGTEIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI19</accession>
    <name>A0ABM0JI19_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tenascin-R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094094.2">
        <property type="nucleotide sequence ID" value="XM_005094037.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854483"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094094.2"/>
        </source>
    </evidence>
    <sequence length="166" mass="19317" checksum="6EE13D89FA9D53A5" modified="2025-10-08" version="1">MQRRASADVDFYLNWVDYKYGFGDVYGNFWLGLEKVHQLTFKRRYELRVDITFNGQGYYANYDNFTLFGEAENYRIRVSGYSGNSSDGLAYHNNQPFTTKDRDNDAKSSNNCAVEYHGAWWYKACHDSNLNGKWGSQEYGEGLVWDTTTGDYDSATFTEMKIRPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI98</accession>
    <name>A0ABM0JI98_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuromedin-U receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101853300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005094263.1">
        <property type="nucleotide sequence ID" value="XM_005094206.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853300"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="63"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005094263.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40941" checksum="45DF81682195B795" modified="2025-10-08" version="1">MEIQNHSSLTPLVDRNGAIDFEKSDLLPNPNVTCDVKLLPSPNLTRLVILLMAVPVCVAGFGANAINLVVFWHQGFRESVNVSLFSLAFSDMLNLMFLVVYALVSADLELGYLHVPPEIWVTCTWIIYSLTLNSCCTAVFISVERCLCATLPFKVKQIITPCRSAITMAAIFLVCVAATISPVFSLFGMSWERNPGTNKSTIVINVHFGNTSPVVYIVTNIVCTSLQVASFICLLVSTGTLMLALRRKTKWRLKMTYMIPRTVTNSRETLPSLEKRAGKMVVIVSAVFIVCFAPAQAIPITYLSLPEFYYGRRYGYAYGVCWAVSYFLYSVNSSVNLIIYYNMSSRYRDTLGRLVRQDFSCLHSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIL7</accession>
    <name>A0ABM0JIL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">THAP domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094481.1">
        <property type="nucleotide sequence ID" value="XM_005094424.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860879"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005094481.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21282" checksum="32377CACE29A9861" modified="2025-10-08" version="1">MVLNCCVFGCKNRKSRGSTLSFHTFPMKDLARKQQWIKNISREDVNGKPWQPSLYDRVCSTHFKPADFKDGTLVKCLKDDAVPTIFPNYPSYKQPTPSRKRPPPKERPFPSPSTSCASSPRLPKYSCMDHTYSYQSVEEHLRITKEKLAETVQKLQSEREKTRILGQKVHRQKCKITSILTPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIY6</accession>
    <name>A0ABM0JIY6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">LOC101860731</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_005094737.1">
        <property type="nucleotide sequence ID" value="XM_005094680.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094739.1">
        <property type="nucleotide sequence ID" value="XM_005094682.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012935921.1">
        <property type="nucleotide sequence ID" value="XM_013080467.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860731"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="15">
        <location>
            <begin position="100"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005094737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005094739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_012935921.1"/>
        </source>
    </evidence>
    <sequence length="705" mass="77753" checksum="7CC5B8ADC0CC925B" modified="2025-10-08" version="1">MASAEVQRRNNAASNNNDVKKRESSSGDKRRSRPVSTISASGVSVNYSLPQDVMQSLKSQTQPCESIDGARISRLCEDNKLLTHYFEGVNTVHDCFQRGVQLAGDKPFLGWKPTPDTPFKWMTYNEVNARAKAFGDGLIKLGLPAENDTRVGIYSQNRPEYVIADQGFLYHSMTPVPLYDTLGVEACNFIVNQADLHVIVCDNNAKVKSLLDRRREMPDVSMMILFEPVTEENKAKAEAEGIQILHLDEVEKLGRENPVESHPPKPDDLCMVCYTSGTTGTPKGAMITHRNMAVCVSAALKVLESCGVEITNEDVLISYLPLAHSYERALESCLVTVGAKIGFFQGDVRKLMDDIKELQPTLFPSVPRLLNRFYDKVMSGVNASKVKKFLFNMALNSKSKELKRGVIRNNSIWDKIVFRTVQAALGGRVRVITTGSAPISSTVLSFLRCIVGCPLLEGYGQTENTGIATVTVVGDSEPGHVGPPLPSLMVKLEDVPEMDYYSNNNKGEVCLKGGNVFVGYLKDQAKTDEALDKDGWLHTGDIGEWMPSGTLKIIDRKKNIFKLAQGEYIAPEKIENILAQSPYLAQVYVHGDSLQACLVSIVIPDPETLPGLASKLGVTGSMEELCKNEEVKKAIFKDLIDLSKKNGLSSLEQVKDIYVHPELFSVENGMLTPTFKLKRSDAHKNFTKEIADMYEKLNAAASAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJP8</accession>
    <name>A0ABM0JJP8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Serine/threonine-protein kinase MAK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101859318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095254.1">
        <property type="nucleotide sequence ID" value="XM_005095197.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824822.1">
        <property type="nucleotide sequence ID" value="XM_035968929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859318"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005095254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035824822.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="70240" checksum="BFECF476BE3EFF32" modified="2025-10-08" version="1">MNRYQISKQLGDGTYGSVLLATTVENNEKVAIKKMKKKYYSWDECLNLREVKSLRKLNHPNIVKLKEVVRENDMLYFVFEFMKENLYQMMKDRDKLLPESVVRNITYQVLQGLSFMHKHGFFHRDLKPENLLCNGTEQVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMSELYTLRPLFPGSSEIDEIFKVCSVIGTPKKEDWSEGYQLAAAMNFRFPQCVQVPFKQVIPNASNDGLQVLRDMLLWNPQKRPSAPQCLRYNFFQVGIDLPRPPPPVSKTPVNLPSQPSPSQKPSTKPPNTYPEPKPADYGGGFGGQRAAQAEDTLGVLPSIPNSMAKQNDSDMFAMTVSKKTSGGRKRWGAGLSDTWDDWTEFDFLPNKTTKKTAQAPKNNAFGKENDDDFLGSLMPKKTQPPKVSNRVNSGRSSASSAKQHYLSKSRYLPGINPKNSARRDSVGQRRDSLGLGLGDWGNPFDKSPPLGGINSNTRTGKAQNDHDFVSGYRGGRGGNFGSPSTNMGSPAGALGGPGSYGAGAAGGRNNFNSPGGYQPSMGGGYKPPGGGYQSSFGQPAVGGAGGYQPSMGGGWKKAAPLPSVGGGGKNTGGASGGNFGPRRTDWASKYLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK12</accession>
    <name>A0ABM0JK12_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Interferon-induced helicase C domain-containing protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC101858480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095509.1">
        <property type="nucleotide sequence ID" value="XM_005095452.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095510.1">
        <property type="nucleotide sequence ID" value="XM_005095453.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005095511.1">
        <property type="nucleotide sequence ID" value="XM_005095454.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858480"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031964">
        <property type="entry name" value="CARD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16739">
        <property type="entry name" value="CARD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CARD" evidence="7">
        <location>
            <begin position="141"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005095509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005095510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005095511.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36805" checksum="F803BAB4E307F362" modified="2025-10-08" version="1">MESASSSEGAQSSLVMDEASNIDQLSYKVRAVFWPYIKKTVKFSHLMTYMPFMRNVQMKIFRAEKLGDNEGAADIFLQTLQQSEEEGKYQTFVNALRAHGYTFLVDVLTDKREILSKQEEHKEVIHIFSRQVGDTIDPTLIAQELLAKSIIFSDDADRIKKAQSNDCTRDAVLLLLDALPRREENWYDAFLEVLLQHNHKQLVKLIDEKYYNQNKGEDSDYSESEPLDPAIVSLHSSESEPPVSQDFSPPAVRPKRGSDGLPVKEQKPNLLPKSDSQEDESIFSLHAKQDRLERKVDELHEIMQDMNKNFKILIEKLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK53</accession>
    <name>A0ABM0JK53_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myoglobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101862340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095612.1">
        <property type="nucleotide sequence ID" value="XM_005095555.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862340"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005095612.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="48882" checksum="26B0D1EDE36E4FF9" modified="2025-10-08" version="1">MTCEMLELGVLGAQLPSYFEKWNELAKSLPSLLREKKVREAVHQLPLLDHSLLQGHQQLRLAHLQLIMITAYYIWQDGDSGVPKVLPKNVAIPLYKISEELGIKPILGHVDLALANWALIDESRPIDFGNLKCLYEIPGGFGGQWFFIVTFMVEFTFAGCLKPIVRVADMLHSVKDKGSGDQAEISDISRKITACLEDICETTCSLKKVLTRMHDHLSAKTFFNSLRPFLAGWGGEGNALPEGLIYEGISDTPIQLPGGSAAQSSTLQVIDALLGVEHTEDKKEFLKFMQEFMIPDHRRFIQTFEQMPFKLRQFMEQNPHPKLLDVYNRCISALVNLRKYHIQIVTKYVVIASKETNEGNYESLDSKGTGGTSLIPFLKAVNMDTQSKFVNSNAESNAKSKTLSFLNTIFHSRATACVLVGLAISFTASAVFKRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKM1</accession>
    <name>A0ABM0JKM1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prolyl 3-hydroxylase OGFOD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101855862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005095916.1">
        <property type="nucleotide sequence ID" value="XM_005095859.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855862"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="129"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005095916.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="64462" checksum="29DC077B75378924" modified="2025-10-08" version="1">MNKKKACIESLAALESQEPPQKISRSGSPPMALSLTSSEEGDSFRRDQAHVLEERFNSTIATDQSPGGGSSTVSTVSPAIDSPLLQHRHSHINGSIFNERVQASVAKAFQSSSEYLDEVSGVKLSCEPFRHCVLPNFISKPEYVTDLESALLALPLRDKNNDLYKFSQSRDLNHSKSSTISTFRTICESVRNFLTDVTGIPLNSKIDLFCSQYKYTDVLLCHDDELEERRVAFIYYLVPESWSSVDGGALDLFDIDEHAQPRDVVKSIVPKRNNFLFFEVSSKSFHQVAEVLSEDKTRLSISGWFHGPPLARPQPYVDSLPPALPYGSIEEEIFYSWFNPLYLAPEVQSDIRHRFEQDSEIELTDFLQVEKYDELMLALQDSTVRWKLLGPANKRNYYVADKSDVPQIVAEYLRVIQSDAVFLVLSNLTGLKLHSLAPLSEGEEGAAAASNGNGESSKSNGDVSNPRYRSEVRKWEHGCYTLAHDTDSEAFDFALDSMLYIDCGKEWSFENGGYTSYIAKGEDDELLSVGPVGNSLALVYRDKDTMRFVKHLNHRVSKLPSPRFFEINTVYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JL04</accession>
    <name>A0ABM0JL04_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein FAM8A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101856569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005096170.1">
        <property type="nucleotide sequence ID" value="XM_005096113.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856569"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039871">
        <property type="entry name" value="FAM8A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659">
        <property type="entry name" value="AUTOSOMAL HIGHLY CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659:SF5">
        <property type="entry name" value="PROTEIN FAM8A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="144"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005096170.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36225" checksum="34BE5E2E21BC14A2" modified="2025-10-08" version="1">MMADDSDDRRSNGPKVDESSSSSFSLPTETSTSQAVHNQSYKNAREYAQALRPWLWHYQSCCAMQSLAANCALQMQTMSMFSTLNNNSFSPNVSTSQLRHRIDPYGYRRPQNLQNDGVPSPPPQNSNRRQDTPEIPGQGVLMKVPTFWKRVAAELIDFTLLFYIKMIVSLCLMTEFSLDHMSFLSSDELFESFSDMDYDRAFAITFEVIALEIINRVLITIFETLCLYRATVGGVAVGATPGKRLMGLRVVSCESIRSLGHSQVLVSPAGSISLRNAFLRSVIKNFTIAFFFPACLTLFFFKHNRTAYDVIARTVVVEELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMS3</accession>
    <name>A0ABM0JMS3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852239 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097348.1">
        <property type="nucleotide sequence ID" value="XM_005097291.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852239"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046099580" evidence="1">
        <location>
            <begin position="27"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005097348.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="58870" checksum="05E8B7A6D0171A5D" modified="2025-10-08" version="1">MKLKLKSGRTSLVVFICYFLTQCASGYNRDEMELMRSEMNEKFDILFNEISRLKEALTTGGQPCENQESVSHQFLEIPAPSIIVLSAKREVSLRKIKFTVTYKLSVDVVPDVSWFRNDEQGSGLDDVVDKRVDIGDGYVRETSAVTDSDRGYANVFVRLAEPTFGEVVLELRNSLRTNTTELSVPGSMLTLIPVPAGDITYNPGHNAKVRVIIPRVNDDSESGSTLKLNTILYDDVSRELKYGEGTGDFVQYADTKDFIETQEMELLLSTSNGSPRGLLVFTNTIRTRTRSDLIAGGHVVTQRVLRPSNETLPFPEGYLGFLRMPRSSHDPNVTVTKCNYADRGCEISCSVFGNNVTDFPIYRIGENGSRRVIPYNTSTLYGGYSVKSHAVVKPNPRGAGQVTYECVAKDADDNTASTYNVVNFYLPLKFDSEASGLWFTDPHTMMVSCVVRVAPITGVQFNFNTKLDSGWRFGEDPDSVEIIPDGLNATKVITIDPKSGHFEHEICEAMQPIEDSGYNLRVVLRLQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNP0</accession>
    <name>A0ABM0JNP0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B9 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101847872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the B9D family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097944.1">
        <property type="nucleotide sequence ID" value="XM_005097887.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847872"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF1">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005097944.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23101" checksum="6BE913D5843BC64E" modified="2025-10-08" version="1">MAAPSVFLLMVSGQIESAEFPEFDDIYCKYCFSYGLDWAITSGLDESITQITKKSRDKHQRFVWNFPIDATFKSTSPSGWPQLVVYAYGLDAFGTDVVRGYGVCHVPITPGRHRLKVPMFVPESSSLLQKLTAWLLGRRPEFVNPRVVAQGEGREVTRVRSQGFVTVSFNIITKDMKKLGYDVLPSDVMNPSIPEGVKGAGPTPGTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPU2</accession>
    <name>A0ABM0JPU2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Serine--tRNA synthetase-like protein Slimp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101847037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098703.1">
        <property type="nucleotide sequence ID" value="XM_005098646.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825734.1">
        <property type="nucleotide sequence ID" value="XM_035969841.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847037"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class II (G/ P/ S/T)" evidence="3">
        <location>
            <begin position="353"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035825734.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58047" checksum="49B516CE00F9E92E" modified="2025-10-08" version="1">MASVKSIAQRFHLRSKTDVYRRCLSLRRPDFLFETVRHLTSSPLGRTQDQRRTHCPQCVKARLCRLRTSYITRNFSSKSVFDNQPPSWLFVSGAVAGAYGAQVNLELGLNERLTGEPLRKLQENISARKMELRLDELIQDYNRLLQLKREREELIAKRNELFQQIRALKSQGKSSVDTESLYQEAVAVKQRIKNSVNQAMWDLEESVTLRGLKLPNELHESTPLSDASQILQEKEGTREPQSMNHVEAGEKHELIKFSNVGPKAYYLKGELAIAEQALAELICGYMEKKDYRLIAGPEFFKTPVLEGCGRDVFDTEGVLTIQHVIKDIVEPMNHLAGVSPMTFAAYMAKLCVGDARLPFNLFSCGRTYQNSDLPGLFGAMQTTQVGLFSGVTESDVDLQFEQTIDVVWKLLQSLGFSMRLSLVPVTDLRQEERRRVELQVFAPSLDSFIPIGYVSDLGDFVSRRLMTCHNRNHGDIRRAKHLHMISGSAVNITSLLAVWLEHTDLDQMGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQL5</accession>
    <name>A0ABM0JQL5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ciliary microtubule inner protein 2C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CIMIP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099242.1">
        <property type="nucleotide sequence ID" value="XM_005099185.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853855"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052329">
        <property type="entry name" value="CIMIP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34924:SF1">
        <property type="entry name" value="PROTEIN FAM166C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34924">
        <property type="entry name" value="UPF0573 PROTEIN C2ORF70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="7">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005099242.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23487" checksum="AB0567C907FD8D0C" modified="2025-10-08" version="1">MSRAAGTLVTTNNATYIPPRFMPGYRGYCPTIKYDYGETYGNQTAKYFQDYRSSVLNSSADPYCKGGSFPTVYTHNPDLVISNRTRTQDRWLQAPKYQLSNVDHDRKEELYQFDRLSQAHREHYKDKSGTVKSIDFYSIPASAQEQFKRNVPFLVLSTKYRDDINLPFLEHVARRKPLIQRGVTSSSQRDREMRDVIFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR81</accession>
    <name>A0ABM0JR81_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101850568</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101850568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099655.1">
        <property type="nucleotide sequence ID" value="XM_005099598.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850568"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005099655.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13949" checksum="3CDACA7207F6EDA7" modified="2025-10-08" version="1">MHLQYLTMSRQKEQILITILFVLVSCCITLSAHAWPTRNNEWEGQRWSDPISQNEEGANSISLRNRLEILDMLKELDRQAKVAAKRDNPRVPEPKLWVSKKGSGGERHIPCFWNVVTCYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS50</accession>
    <name>A0ABM0JS50_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroanticapsin 7-dehydrogenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101859940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100281.1">
        <property type="nucleotide sequence ID" value="XM_005100224.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859940"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005100281.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18257" checksum="0C83CA4BBF08E34D" modified="2025-10-08" version="1">MTDYLEKGKTVTRDYYSGLLIKLPSELVNNAGIFAARFIKDLDENAVEENFNINFKVPVLLSKLALPHLLKTKEWGPAGIRVNSVSPGAIDTPIFSKILGGDKAKMDMVAQMQSKLHALQRNGEVTEVAETVAFLASDASSFVSGTVVFADGGRHSYPAGSGSFSGKSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS98</accession>
    <name>A0ABM0JS98_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cyclic AMP receptor-like protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101857805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005100358.1">
        <property type="nucleotide sequence ID" value="XM_005100301.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857805"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022340">
        <property type="entry name" value="GPCR_GCR1_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF43">
        <property type="entry name" value="CYCLIC AMP RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02000">
        <property type="entry name" value="GCR1PLANT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005100358.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36048" checksum="E96593C96C4F148E" modified="2025-10-08" version="1">MPLNGSCISFPDNPSHCDAVVVARKVSGSLSLIGAIFMVFVIWLFKRYVAFSQRLTLYLSISSLLHSIGFLMGSRIDDGPFCDFQGWYITYFHWQVMLLVGCITFNLFMNVVRLTTTAKFEWVYVVICAAVPLVVSLLPFIDNVYGPSGSWCWIVEDTKWRIGIWYGPLFTFIIILIAVYGFIIFTLLRKASTWEGTYDPNTHRQHQLMKEDIKPLRFYPFVYLAVSVFSLINRIQNAISPDYHVFALVLLATMTSPLQGALNAIAFGIDKEILFKLRPSEILVAFKSKLAPGSTVQEYPQPDRDTDQLEIYVTTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSQ1</accession>
    <name>A0ABM0JSQ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COMM domain-containing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100624.3">
        <property type="nucleotide sequence ID" value="XM_005100567.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858946"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055184">
        <property type="entry name" value="COMMD8_HN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22838">
        <property type="entry name" value="COMMD8_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="117"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100624.3"/>
        </source>
    </evidence>
    <sequence length="187" mass="20848" checksum="915EF4098D7DF88C" modified="2025-10-08" version="1">MADEKWESAFPVLCKTSSADIGNVCHAVAESFCQDDVISADAFLSTWTLEEWWQVRSVLTDIMRSAVGKGWSKEKISEELGSLDEPYKKVLIDVINVHEASLRKKLLLDTTAVSHAVLSDFDWKLQLAMSSDKLAQLQELLVQLDLDVREAGGDRKRVILEMDKSELGRLISSLEACGKSVQQMTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSV4</accession>
    <name>A0ABM0JSV4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PH and SEC7 domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005100703.1">
        <property type="nucleotide sequence ID" value="XM_005100646.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857030"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13295">
        <property type="entry name" value="PH_EFA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF376">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="546"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="768"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="730"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="909"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1027"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005100703.1"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117477" checksum="3864D61BA5AA6B70" modified="2025-10-08" version="1">MADRASQGLSRIPVPMKTPPPPEREHMREVYVRDVVDGPNNPPKQQQHQSVGDHNNENGSVCPNKTVHSPATPKKGKGFETYLMTGEMIIRTNTNPVVCEKTGADQKDDILSKTAKESQIPKLDHGDRKNTPHRTKVHKTQPSHSVITSPKISSKIPGPIKSPQQNHQTGSPRFPRPVRDGEMAATVNDSAGFPIIQAPVAEMEELSDLSQSSCSESEMGLGNDPASSSPKSLPTKNQAAEKLATPGPSSSASRLEEAVETLDMLQATLPGCQFEGLSDTSASFPEPLSSGDSGFVHDGHASDPDLPDRGTMASFEKCFSEREGFMSDETLTEREDASDSCSTNTCSSGQGTSHSQTIVASSSGEKFMLDGGDRPLVRTSKSHENYLQAVTGIAVVNIDIEDNLAYSLDTLTYHDSSDSSLDKVSQEPVQVSRSLHNSPEKKSEKATNGEREFMPGFISLEDSKQIKLKLNKQREEQMDTLDESSTEDNTKGEETNNSSNCYPNFQGSSINSQRHHSLNNESEDSFDESRSYDGMLVNARGESLQLSVLSDDSDAESLYHQPSKAVDRPSAERLAKRLYNLEGFRKSDVSRHLCKKNDFSNLVAEEYLKFFYFQDDTLDVALRKFLSQFSLFGETQERERVLAHFSQRFMECNPGSFNSEDACHTLTCAIMLLHSDLHSRNVRRRMTCQEFIENLSGLNDGENFPKEVLKAIYQAIKTGTIEWAVDEDMPEMDSQGQGQDQAVPPQSPGPQALGSNPFLEVPDPSKATEYKKGYVMRKCCMEPEKRKTPFGKRGWKMMYSVLRDMILYQYKDEHHFSKGQFVESSHNAIRIHHSLATKAADYAKKQHVFRLQTADWAEFLFQTGNPKELQEWVDTINLVAASLSAPPLPGAVGSRAKFQRPLLPSSFTKCNLREQLQNHELKVEELEQELRLHRVAIPEKGSKTSIIQDYLEKETYLEFEIKRFKTYVYLLQGKLSAYPELEPSLAETTIGEYEEMGAGPSHIPVNQVAGVKQGSAGKPVQRSLSDSDSDNSDTGGDESLAELPRAPVINTLSESTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUP2</accession>
    <name>A0ABM0JUP2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 206</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101846294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP206 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101930.1">
        <property type="nucleotide sequence ID" value="XM_005101873.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846294"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021897">
        <property type="entry name" value="FAP206"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12018">
        <property type="entry name" value="FAP206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005101930.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="72234" checksum="D487CFB8A19EA25B" modified="2025-10-08" version="1">MSRAQAESVIKNIIREIAQECAGKGQAVSETLVAFMVKAVVLDPSNEFNVDRTLTKDDVQKLIRLCVDRLMDSRSPALDTVKMQVYFDMNYTTRADFLDEHRRVLESRLLPVIREITDSRARTREELESLYRKIVSAVLLRSGLGSPTDIAVVREATAALQSVFPQTELGTFMTLTKREKERQLTELTMIVTGIRLFNKECGKGGEGIDDLPAILNEAIPATTQSVDGEIQGTLQSAYKYTALIEEMHKGQPKEGPSIQLLKEALINTRQHETFLRIILNDVISCAHQVGHLQGQLAIRMKQLQATVQSKTAVPTAQVYPQFIHLAQLWSSFQDEMVLLSVLSNILASLEPFTRGHRELFSDDVLVPYLEGLSVKTDKERIEETSSQRVNTKDYQVEGHDWLFLDTTKNFAKLRLQYRGYCAYSLGKYDRLLLPANPEIGVLRFREHYYAFSSKDAAYEFAQNPQEYIAMVADGAKKSPELIQLLELHTQFSTITPYSQSREAGKMIEKPVTKCDSASQTDTHILESNIVKTYEWNEWELRRKAIKLANLRTKVTHAMQTHGSNMRRDNETQVYLPKDQNTQTKRDNYSNVSKPQVFLEGLRGGGMSVPTAMNKVDLTVDVSEPPIVSQYMVRPKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWF3</accession>
    <name>A0ABM0JWF3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RPB6 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101861523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103120.1">
        <property type="nucleotide sequence ID" value="XM_005103063.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861523"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005103120.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14296" checksum="D402286A86C30D5B" modified="2025-10-08" version="1">MDADEIEGDDFDDGPDVEDDEPLDEPIGNEQGERIEVITDGANGQVEPQKRITTRYMTKYERARVLGTRALQIAMCAPLMVELDGEIDPLKIAMKELKARKVPFIIRRYLPDGSFEDWGLDELIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWZ9</accession>
    <name>A0ABM0JWZ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AT-rich interactive domain-containing protein 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103529.1">
        <property type="nucleotide sequence ID" value="XM_005103472.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855507"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103529.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="39438" checksum="308C7A3BA045FCD0" modified="2025-10-08" version="1">MLVSPRALDMNANAEFSPLHQRRLKQQMNNTRLHDNHRHHLLAHLGQNQNTTAFMQQQQQQQQQQQDLSRRAFQNNSTATKSSFSPRLGHRVKFPPHITICAPDSGDVTALKYEELDNEVFHSPPSPTTSSPTRTRAVPSDEKHEVHAGRLYLIRHSGSGSSGGGGSPVPPSSPSKSPSRSPVTSFPFRSSPPFMTSSQSSSPSSSTSSPPPFSPSPLSCSPPTTGQGNSPLGPRKTSVYVRVYRCNLDHFAVISRDAVYTAKPVYVNIRRCRLIPGDTLGRFVLAGKLDSGELIEFETPELSSLEQWLDVFQTCTPPGSPSRMAGGAGSGANAASGGGAGGGANVNTPPIPRSPALPTLTETDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYL0</accession>
    <name>A0ABM0JYL0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104591.1">
        <property type="nucleotide sequence ID" value="XM_005104534.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846021"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF4">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="667"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="874"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="950"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005104591.1"/>
        </source>
    </evidence>
    <sequence length="1066" mass="116797" checksum="02E0CF8728AB4476" modified="2025-10-08" version="1">MTSTQLSPRFVVFVVVSLISHLLELAASGLLCHALLQQGQLKTPWFSVAAGLLIIPLVLLQLASAVLTLRRKGDSASGCEVTATAILHLLQLGFISRHFAVLQEAPPSTARAELAEMIVLRLAFALSSGCTLLLLQGYLLLSDAHEPGWAWAVYVVALTTLLSVTWALATFRRRASELDLDSVLITWPGTVLKVTWRGGEVLVRVLCLGLFASLYTHWIFLVLGLHWLAMAACLCIPVITALDWRGAGSGRRAVFCLLTSFAYIFAFINTSAENAVFRYTFYYVVLFLENATLIAVWLVQCSSAEFERNSVYVYIAAPVFAVYITAMIVYYKFFHVAGDKAIPGNIGCSAVTACASCKLGSHSAHPPIPPRPGVNGGWLQSAVYCGQYYKHAAQDSLLDSVSERNSTATVSSSHARLQHKLATIHDHVSEHEGSEPGPPCSHPQHHHHHPYQHHDHGVCPVAVSQTAVKSEAGSPRGKLPRRKEKKKKSLARNTTSESELSSVRTDCDMSEGSGSNKRPVWLPSGDSNFANQLLNYSLETFDTADTADDERSSVATGCHGYHANIPRSPRGGELSSPRHLHQHHHQHHHPVPGVVGGASLQRHGDHHWYSDGYSTDRTLDWPRLPMTSLQRGGVWGMADTESEGCTGCQCCHGDSEVSSIMRSITSVPEPTDETQDEGQNSEGYHSQPRGHKHSHRPHHHHHHERSLDPSSGCNKKQKLDKFSPRDLNTVSENNRLSKHSKISTKDSGFRREEILSSPASDPSYGPKAKRKHSPRRKVHTSEKYEKATSKSKVLDDPISINNCLPQVTMCSDDKDVEEETVVQSDKLASELLQHSVSGDKKRKKDRINSSSAGVSDPRFSVRVMADVTDVLEEQTSHVRSLDQGQVKGKGKGGSINSPRVEEPNKGKGINDESQVEETNKDTYAVSAHAKNKSKVSRVPSSSLAVDNANEELKGVEADNVPDEEKEKESEGQEASPNTSESGERSDEIIYENIWQVKPPLVKPSLLQQVRGVTSVPSKPCRKTAGKDVWYVCSESEDSALPPEALSSSVDGFTASDESDISMEIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYX2</accession>
    <name>A0ABM0JYX2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kappa-type opioid receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101855584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005104804.1">
        <property type="nucleotide sequence ID" value="XM_005104747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855584"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005104804.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39652" checksum="3870A2FB4D95D907" modified="2025-10-08" version="1">MSNQSNPGDKERVELLSDETTHLVMQILMYGVTPTISTLGVLGNVFSIIVLLKHGLHKCSNILLFCLAVCDFVYLIAFNSVPKLLYELSGVAFAWDYNEVTAHILFVLYTLFHFLDYAIGLSSLAIPMLITAERLVAVFLPMKFSRIITPARTWTAVAIICLFWIVLIFYSSLWFQFKYVFDPKRNISMGITIRSDRYYQERDVSKALDDVIEYLTLKIPPAFTLIGCVIIAVKIKMASAKRRKMTSSGAKETKSNRTNKMLLSVCAVYTMTCAIVSLPNYLPQYGYYTMTGDAPNNVGRIGYQVMNVVGCTNSSCNFIVYVGLNKNFRDTWKSLFTPCGYREKVPKERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZY5</accession>
    <name>A0ABM0JZY5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855585</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105496.1">
        <property type="nucleotide sequence ID" value="XM_005105439.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855585"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045153338" evidence="1">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005105496.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22612" checksum="1D5A3AF582A204C3" modified="2025-10-08" version="1">MAHHTLTTILVILALTHASLAFSFRGLDKRACSDSMACLVRVPMLVDLIEKDFAGALLPLTYEPVLDFLCGQRENITGCLTDVHCEETEHKYTGGAVLELLDYACNSGRADLLEERACISRDDFEEGILQCAGILRIESDLTLTQKLAWLGDNSCQTIDNMYKCVETSTEHVCSGRAARLMGQIYRTIMREVAQDAECEQDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0F7</accession>
    <name>A0ABM0K0F7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable beta-D-xylosidase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101852872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105835.1">
        <property type="nucleotide sequence ID" value="XM_005105778.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852872"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF42">
        <property type="entry name" value="FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047278859" evidence="4">
        <location>
            <begin position="32"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="5">
        <location>
            <begin position="685"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005105835.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="86199" checksum="BA29C0EA2F49C124" modified="2025-10-08" version="1">MIKSTMSSRLPCDIIRVLILTIALLSHGSTSSKFDRHSQSHTIRHMNINEDQAQVIDFPFRNTSLPWNERVDDLVSRLTLEEIQVQMSRGGAGDFGGPAPPIPRLGIGAYNWDTECLRGDVQAVENATGFPQAIGLAATFSLDILYNVARATGQEVRAKYNDFIKRGIFATHTSVSCFSPVINILRDPRWGRNQETYGEDPFLAGILVENFVTGIQGDNSRFIMTSAGCKHFDVHGGPENIPVSRFSFDAIVSDTDWRMTFLPAFKKCVEAGTYSVMCSYNSVNGVPACANKKLLTDILRTEWNFKGYVVSDQGAIENVIWQHKYCNNSVDAVAACVNAGTNLELSSNLPTPVYMSMMDAIQQGKLSEDLVRERVKPLFYTRMRLGEFDPIKDNPYAQLSMDQIESAEHQQVAVTAAMKSFVLLKNQDGILPLKKEEFSEVAIIGPMSDDITQVMGDYAPQQDRSFSTTTLDAVRALYPNAKYGQVCKDSTPCTQYNKAAVPAIVKDTELVFVALGTGQAVEMEGKDRPDVELAGHQKELLLDVLDNSGDAKIILLLFSASPLNITFADQSDRVVAIMECFFPAQSTGKALYNVLTNTGPYSSPAGRLPNTWPLYSTQIPPMVNYSMEGRTYRYFRGDPLYPFGYGLSYTQFNFSNLIYNTTIKAGASLSVQVDITNVGDVDGEEVLQCYISWNDKSLSVPQLQLAYFDRILIASKQTISRSLSIFSESMAFWQDGKWVIKAGGMSLFCGGQQPNQKKQVPSNVLSGTFTITDSIALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1E2</accession>
    <name>A0ABM0K1E2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Surfeit locus protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106485.1">
        <property type="nucleotide sequence ID" value="XM_005106428.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845870"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008833">
        <property type="entry name" value="Surf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34348">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34348:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05477">
        <property type="entry name" value="SURF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106485.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34250" checksum="F8B4D16DD409B4E1" modified="2025-10-08" version="1">MASNDVQKYLDDFPSLVLDKEKQRIRCRFTNHEMPATVSALESYVKGKKFRKASEHRAYNYQQYQPHLMPSTKKKHLHELFCKLTLRHIGRAPQDVERHVKGKKFKKALARWETCQKTGEKFVPRAGGRQPTGGTSDSDSVGGGDNYWDDDNSDNDDNDDMSDLYPDEIFKQGKAGDANSDDDDDDDDIDDSPGTDEDNGQNDDATPPKRPKQNTSKQKKTKKEKLKNVVEENEEGEEDSDYDMDVLNSGKRNSDSEEVGVSSASTSVPSSTHKSEKAKSNKRQHPKKPSNVGIVPGAKKKKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1Q3</accession>
    <name>A0ABM0K1Q3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium/calmodulin-dependent protein kinase type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106686.1">
        <property type="nucleotide sequence ID" value="XM_005106629.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852266"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005106686.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22138" checksum="2846E14725C2447D" modified="2025-10-08" version="1">MDAVEQHDAFFNSFNLVRGPCLGSGAVGEVVLASAKHNSSLKVAVKIVTFETEGCKGDFLSEVGFLRDLRHPRILKMIAFAMDDHHGFMLSTYFKNGTLRDTMSSDHPVEEPRILRHILDVASALQYIHGLHIFHQDVKPRNILLDDQDRAVLADFGLARQASDSSAMVMKWRTTPGYSGPETRKRRPMSPFKKEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1T3</accession>
    <name>A0ABM0K1T3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein ILRUN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101861536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106727.1">
        <property type="nucleotide sequence ID" value="XM_005106670.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861536"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14349">
        <property type="entry name" value="UBA_CF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039517">
        <property type="entry name" value="C6orf106_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nbr1 FW" evidence="2">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106727.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="29748" checksum="0ACE5D642B52AFD0" modified="2025-10-08" version="1">MDVDIDNDFDGKFLDQFRSMGTTDRDVLIAEFQAVLGNQINPESCAFFLDMNNWNLQNAVCSYYDFEQPTNLQPSMSVLGDLTIGDGESVAPSTTFIKTWKIKNQGMDRWPPGCHLRFCSGDNLSTVERRMVDALLPGEELDVSIEMRSPAASGAYHSMWRMSTATGIYFGDVINVQVMVAEGGLLGLTQQLARIGGTPGQVSIPNPFPQPAGHHSSSMDAATQPQPQPQPQQQQIVLFSGGPAAGQMQQQQDPTGGGGLERPAASIEEDTDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K274</accession>
    <name>A0ABM0K274_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 41 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101864013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endosome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Early endosome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle</location>
            <location evidence="7">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the VPS41 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107003.3">
        <property type="nucleotide sequence ID" value="XM_005106946.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864013"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23413">
        <property type="entry name" value="zf_RING_Vps8_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="589"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="812"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005107003.3"/>
        </source>
    </evidence>
    <sequence length="871" mass="100616" checksum="F64E994DF9E168EE" modified="2025-10-08" version="1">MADSKASETQAVREEKTQVEEEDSEEEEEDDDDSDNTEEEVEPKLKYERIANDLSSILSKDAASCIAVHPKFLALGTHWGMIHILDHIGNNIRDKEVTAHTTTVNQISIDDNGDYMASCSDDGRVIITGLYATENNQLVTFDRPVKAIALDPYYYKPGTGRQYVTGEDKLILNEKSGFLGRHKMVVLHQGEGAIRNIKWGGDFIAWASDKGVKVFDMSTRSKITKIDKDHDLRPELHICQLVWRDARTLLIGWGDRVKICVVKDYGRTDVKDNLPNRYVEIIAMFTTDFFVCGIAPLATNLVVLSYDKIGQKQEGGRTVANRPHLQILEPHMNYFEEISNDALSIRGFQEYRCNDYHLECIPEENLYFIVSPKDVVVARLRDQDDHITWLMEHEQYEEAMAAASEHSRELKMHTYSDIGRAYLNYLIEEDCFDEAGRLCVKILGKKKELWEEEIYKFAKINQLKAIAPYIPRQDPRLNSAIYEMVLNEFLASDSDRFYQLVKEWPPQLYDNESIINAILGRLDREKDPEVLLQSLGQLYAHQKAFDKALGIYLRLKHKDVFHLIHAHGLYDKISDKIIQLMDLDQEQAVKMLLDNNETISVEKVVQQLNKSQRYLYVYLDQLVHRDVQGTQKYHGQLVKLYAEFDRPKLLPFLRRSEFYPLQTAWEECEARDYVKEQVFLLGRMGNLTQALKLIMERLGDVNHAILFCMEQADEELWENLIDYAMNKPQFITALLQNVGAHIDPIKVISRIQKGMEIPGLRDSLVKILQDYNLQLSLRDGCRKILVADSFNLMERLVKTQRRGVFVDGSQLCTVCNQRLTVNDLRYASNLIVFHCRHAFHEDCLPAFVTNCIICSSVKKDRRPGSREHFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2M1</accession>
    <name>A0ABM0K2M1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101858440</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101858440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107314.2">
        <property type="nucleotide sequence ID" value="XM_005107257.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828027.1">
        <property type="nucleotide sequence ID" value="XM_035972134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858440"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34714:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34714">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005107314.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828027.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="53694" checksum="EDBA6C26A9B2F679" modified="2025-10-08" version="1">MRDLMNFGRLRRYWLVVLSMALLLIIVLYYAMYDRPTPALVNRTSSNKTAPRPKPASRAYSQWPPFELELVSPELFREKCVTTSSNFSIAHLADILSEWRRSVHPNCRELYQKFSAIYTVERRVGSVVIPGTFKAKVQAWLGQREELYQELFHQDIIHVINQYTRETTIFNPLRDKRPVTKPKESEKDYLQRITKESAMNCDFCRFRNFTAEHDFGRVETDLSFSASNIFKLDRLHAVITIKAHDPVNWSYQQYMDMMRLTMVWLKKAHHAEPSAVFPSLIWDLLPKSGSSQLHPHNQIFLSPNRYHGMVEMWRRAAQEYVADFDSNYFTDLVSLYSALELVTTHKSAVALASLTPRKDNEVVVIAPKADDDFFQMIYFVVRAFMDDLKKYSFSLGGGFPSMKTHPGLAEIPAFVRIITRGVMTEIRTDISALELFTATNVNIDPYKVIQVIRQSVKTRAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4R6</accession>
    <name>A0ABM0K4R6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101850116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108722.1">
        <property type="nucleotide sequence ID" value="XM_005108665.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850116"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045075900" evidence="2">
        <location>
            <begin position="20"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Apextrin C-terminal" evidence="3">
        <location>
            <begin position="202"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005108722.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46473" checksum="91F36C689FA7D283" modified="2025-10-08" version="1">MMSKIALVLLLAVIGGSDARWYLVTSHPHVVLDVTTDPALTCKYTSGYYDFSQISRIRILKNDAGSHWELVAEVRDTSPDAPTSNTGLKVRGHVGSEWNSFLEISWPTAEMNTLGRYKCEVMGFDSDSIAVIRDTPIQLMVEDTVNATQVLHLLLREQAELQHEITEQRDNCTNTVNQLESAIDDLENRVYRMEASQRSRTWPNGLYGLLSPNTGCPNNGIDSWRTGQLKMHTESSNSTNLNSVSTPNNFAQPIFESSNSDLFMNQHFCVKENVGIFSDWPRGTYCINKRDSGSCPNGFSSGYIRFDDEDSDRATQTSGNVPEIVISGSDYQIYYCCRSDSAPGVAISLPTENPFYLYRYKGTCQRVLGMTVSQQYMYFDTEDSSNQDKYENLIHPDGMADHNVRIELCYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5Q2</accession>
    <name>A0ABM0K5Q2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate synthase</fullName>
            <ecNumber evidence="3">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101858068</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005109348.1">
        <property type="nucleotide sequence ID" value="XM_005109291.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858068"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="10">
        <location>
            <begin position="50"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005109348.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38109" checksum="1AD5ADBF11D91268" modified="2025-10-08" version="1">MESMDTSLLQDKQKLVDDAMNIENRSPSSAKSSDDVEKSTVNSNRHEEYQYLDAIQKIISTGCLRSNRTGIDTKAIFGMQMRYSLRNTFPLLTTKRVFWRGILEELLWFIRGCTNGKELSEKGVHIWDANGSREFLDRRGLQHLEEGDLGPVYGFQWRHFGAEYSNMSADYTSKGVDQLQQVIDKIRNAPNDRTIIMCAWNPKDIPKMALPPCHCLVQFFVADNRLSCQLYQRSADMGLGVPFNIASYALLTYMIAHVTNLELGDFVHTLGDAHVYVNHIEPLQEQLKRKPRPFPKLIIKRKVTNIEDFKADDFEIVDYKPYNKIKMDMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5S5</accession>
    <name>A0ABM0K5S5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-rich adhesin for platelets</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109389.2">
        <property type="nucleotide sequence ID" value="XM_005109332.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847151"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.710">
        <property type="entry name" value="SATB, ubiquitin-like oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038224">
        <property type="entry name" value="SATB_ULD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032392">
        <property type="entry name" value="ULD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51982">
        <property type="entry name" value="CMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP" evidence="2">
        <location>
            <begin position="583"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005109389.2"/>
        </source>
    </evidence>
    <sequence length="675" mass="68772" checksum="636B8E78B2EEEEDB" modified="2025-10-08" version="1">MELKTCVDDDLSSGRSWPRNCESESNIPLVSIRERVGREEENLHINTNDKDATNTDDGSVTPPASIADINDNNTAHTNDHHHHDDDLDNNDDDDDQTDDTGMNEKNDDKPSDIMNGDMDVDETGGPSVKMMNHDVVMSDDDGGRDILKLKLKFSEDEAGGNSSMSSRKACGGLDDQRESKELEGARSEAVMKDQNQQHHQQQHQQQHQKQHHKQHHHHHSGGNGVGVSCQEQRSLSPHPPTTSLSLSAPSPSSLVPPAPSSSLSLSGDSTIVAAATITAAEAATATAAATSAATSVGLSSSLSLSSSMSQPVVAAPAADATDSSLLTSSSPNFSPSSATWAKTATAKTAKTAHEQQQQHQLSLSAASSSLTGAMPSSKSPSSRTSSSSSSSSSSLSSPSPSSSPPTTTTSSPPPTSSATSPPLGSNTAAVIPTTTSSTTSCSTLTRTDTKTAVVSPSAAVSSSAAVVSAAAVSSKAAAAAAAQTASNSTAASSSSSSSTAAAHRARDDVLTTTRTRTPAVSATDFRDGKDRDANDSRDGPHSSTATSASSAASSSSSLSAAPIVWEASTGKKSASSALPPTSCRSLPIHCVVEQGPAPSSGGETGGALSSCAADDHHIHHPLGDSRDGGGGGAQGFGSFGHVILDTYAILPGLTLFSDIVAASLFRLGYSASETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K641</accession>
    <name>A0ABM0K641_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC101860611</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005109617.1">
        <property type="nucleotide sequence ID" value="XM_005109560.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860611"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF337">
        <property type="entry name" value="GATA-BINDING FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="352"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="406"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="788"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005109617.1"/>
        </source>
    </evidence>
    <sequence length="859" mass="92016" checksum="3194E2534783D684" modified="2025-10-08" version="1">MIEVMQQPGLSLSSRLLPGPLLPSQDVETFFHHLDSKTVHVTAATTTAATAAAAVAAAITTETEQRRQNHLQKHQQQQHQEHSHLLTSTHEVCGSTRLPSNSDSPLRPGDSPNSVNSESGNSSSPSSRSSASSSADSGVICSLDVSRYHNDVRIVESDVTGNLISDPRSGDVTRYQTESFSGISVEGREKHPSAAMYQGGLTLPAPTGTAYGQDAVTNGYLHSGTSPVFVPSSRAMLPVQYMTTPTQSMAPPTSSSLWNSAQNDVATAGFPPAGTLHPSSFPYNSTPGAQLSSPNGRGDAGFATPLARHGSLGGYPAYMGAELSPWNTFNNMALQQGFRPTTGPDGQEYWADLEGRECVNCGSISTPLWRRDGTGHYLCNACGLYHKMNGLNRPLIKPQRRLSASRRVGLSCANCHTTTTTLWRRSNEGEPVCNACGLYYKLHGVNRPLAMKKDGIQTRKRKPKNVNKNKSPTKTEDNDAKSDNSPSKSNASGNNSTSNNSSSSSSNNNNSETTINKNNDAVKTEAGKTSKQETSPKQNSAKSPSVYAPSNTGYDLITPKTEYTDVSKVGYQDSTKASYVMDTAKSAGAYDIHKASAYPDVMKYDVDSNKHHAYLDPMNMAYLEAAKSAGYFDMSRQAYNQYDPSKSASYLDPNEKLGGYMEHGKIDYNTAAIKSEYMRAGKPEYMDVMKSDPYLIAQRSDYAEKADYHTMKQMGYDTMHMKNTYMSAMQKSDYSMVPSGGGLKPGSDVTAGSSHIMPGMSPASSHSHIMTSSPHIQNMMTSSAALSTMPSAHGVPTSHHQHAYGLPAPAPPSPKAEAIPMTTDASGYRGSDVSGGSGQALRVSESAASSSLHTVPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K651</accession>
    <name>A0ABM0K651_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitofusin-2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101845502</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005109637.1">
        <property type="nucleotide sequence ID" value="XM_005109580.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845502"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09912">
        <property type="entry name" value="DLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006884">
        <property type="entry name" value="Fzo/mitofusin_HR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF3">
        <property type="entry name" value="TRANSMEMBRANE GTPASE MARF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04799">
        <property type="entry name" value="Fzo_mitofusin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111479">
        <property type="entry name" value="Fzo-like conserved region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="12">
        <location>
            <begin position="97"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005109637.1"/>
        </source>
    </evidence>
    <sequence length="764" mass="86152" checksum="1269C813CF377DE9" modified="2025-10-08" version="1">MSGMVHRSMDDEDAETGASNRKLGNGHNQESALQLFVNAKKKINDIFRNIGQYVLEADKFVQDVTSVPECSVIVGPENSEVVHGFCEKIDGITEVLARDHMKVVFFGRTSNGKSTVINAMLRDKILPSGIGHTTHCFIQVEGSDSKDGFLLTEDTDKPKSITDIKQLASALSDVKLQENSLIRILWPKEKCRLLREDVVLVDSPGIDVSPDLDLWIDKFCVDADVFVLVANAESTLMQTEKNFFHKVSEKLSKPNIFILQNRWDVSEMEEDIDQVKQQHIDRNSDFLAEELKVTDKKGAKDRLFFVSAREALASRLNNDNVFATPERVLLPGFQARLFEFANFEKEFEVCISQSAVKTKFEQHTNRAHYINSELRTVMEEAYTKSLSLQDEQMQLRKEKSDRLSHLDRQLDLLTGEVKNKIKAMVEDVERKVSCALNDEIRRLSVLVEEFERPFHPDAMLLNVYKKELHSHVEQTLGRNLQAKCSSVLVQAVEETQREMTDRLSAILPEESKQQLLNLMPKRDFEIAYRLDCRNLCAGFREDIEFRFSLSPTALVQRFLGTKGQVRFLEGSDSLFQRGRQMSSEAAGALGGDNPLSASGGGDNEILISVLATFASLTSRSTLGAAVVTGLVAKAAGWRVIVVTGALYGGVYLYERLTWTSKARERAFKQQYVDYASSKLRLIIDLTSSNCSHQVQQELTSTFARLCHQADVTKQQLEAEVKQVDKGLTIIKEISSRAKSLRNKADFFDRELQGFVAQFLRHAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K762</accession>
    <name>A0ABM0K762_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101852964</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Nup35 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005110349.1">
        <property type="nucleotide sequence ID" value="XM_005110292.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852964"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12722">
        <property type="entry name" value="RRM_Nup53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017389">
        <property type="entry name" value="Nucleoporin_NUP53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038119">
        <property type="entry name" value="Nucleoporin_NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9 10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="12">
        <location>
            <begin position="182"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005110349.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="35596" checksum="4FE117FB0F9BE7E6" modified="2025-10-08" version="1">MFSIGSDSMQHGHDSMMSLSPSSPGQHAPSHSSPFLPGYLLGDHPSHHHAVSSPRLWSSGSSQSPGPKSSAVHFTPSGPGLVRRDSTRKVGGPPVKSLYSSSAADTSVQGGFAVHGHSQSSPALRNLSVSSPAPPTTGLFQMPGGSRGDTSVSGLGVPQTMPLSPAQADPFYTQGDLKSDDQLDETWVTVFGFPPGATSFILQQFSQYGTVLKHVVASECNWMHLHYLSKIQAKKALSKDGKVFGGCMKIGVTPCIEKSVMEEKENSYMSRSLAVEDSIHSPGELNSSKLTPIRPLTAAYVASRGEYEVLRDKQTPKRDAGLVSKFKEYMFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7A1</accession>
    <name>A0ABM0K7A1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC101851899</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101851899</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110427.1">
        <property type="nucleotide sequence ID" value="XM_005110370.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005110428.1">
        <property type="nucleotide sequence ID" value="XM_005110371.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851899"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005110428.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="69101" checksum="CF01FE021372F617" modified="2025-10-08" version="1">MLTQCNTTSALNLDRVLCWASNNASINSTQDNETTTDVTEDTNEDMVVWVPYLGLVLFLGSVIVLSVSFYSRYTRALQRRQSHKDYKERNIDLKRTRLHCIMHMAPKPSQEDYFALENEEATNSKRQNNGTGYPYYSYNPNSALRLSSSLHSVRDFAASDPDLPSYEQSSRRVSIHALHPSQLPQHLLRRADFPQKTRPRYRERQGLYSQCHHCQCCCHRHPDRWNTQPAQMDTSVEKEDKEVLTNALNARRRCLSSMHKKRNLSLAKSLKRDKKAFHNDIEPKPLKQKGAKLTRSEKKKQSLEIKHSDFQPESSEARPFPSTGGQDTTTGAGEYTHSAQSRHQDSIAYTSGEKSESTVEDIYISPQTKESDSPPSTLSSPGSSRSQEDISALPPDRGKKRISLPRQTTSRDKTASVLESGSTHLTGFTNYAFDQGPSDVDEIICPSDNTKLVSSVHKNCSESRPESQEQHFQRTRTSFPIFTPVPTIHSSEELIAEDMASTNSNLLHDRNENHESSSHGDRKTTGELTCNCSDFSVGKEASRRQVEGGGWVEDSARSKDKCATKRDSQMFSSAKNTSYFSKPMDSNAGNTEQIYCIADHATFTKGDERTMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8E4</accession>
    <name>A0ABM0K8E4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Farnesoate epoxidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101855833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111240.1">
        <property type="nucleotide sequence ID" value="XM_005111183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855833"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF31">
        <property type="entry name" value="CYTOCHROME P450 307A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005111240.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19427" checksum="EAC26573F76CE5E1" modified="2025-10-08" version="1">MFPAHREYLVNVSLETLRYSSAAPQLLPHYACGDIPFEGHFIPKGTFLILNAWYFHHREGLWEDPWEFKPERFLDSDGQLLDPEHPTRQNFLPFGTGKRSCPGESFSRIRIFFIVVTLLQKYRFLPPVDVPLPSANPKGRETKTVICPDEFKCRMEPRLTAKAESCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8N7</accession>
    <name>A0ABM0K8N7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 53-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101845284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111442.1">
        <property type="nucleotide sequence ID" value="XM_005111385.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845284"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF1">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005111442.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36274" checksum="8AB26BC4A8868C27" modified="2025-10-08" version="1">MAASVLKPANALLGAVSVASRALKKNAAVVVTSCRYESGLPPLKTEKISDNLQLKSIQDDSQSSRPLILLFGWMLAKQKHLNKYGNMYHSKGFDVLSLKMRPGQVLIPQRAQDTVEHLLSVLEDSSLAQKPLMVHGFSVGGYMYGEMLVKLRQQRARWQGICDRMTGQIFDSPVDYEGIAPGFSRVLVKNRLGQKLLLNTLEGYLKLFQKPITRHYLASSQAFHDNNLRLPSLMLYSRADPIGVDTRIELVIKKWKAAGIPVMSRCWESSPHVSHFHRHPDEYVEAVLGFLDSIRLSQPEQKDSKIPEEGKTKAKEEIQQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9Z6</accession>
    <name>A0ABM0K9Z6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Toll-like receptor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101851910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112480.1">
        <property type="nucleotide sequence ID" value="XM_005112423.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851910"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047124174" evidence="12">
        <location>
            <begin position="26"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="883"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005112480.1"/>
        </source>
    </evidence>
    <sequence length="1032" mass="119109" checksum="1C18951ED11F4769" modified="2025-10-08" version="1">MLRTLYSAFSTSIVFFLLAVKTLSAASPKGIRISQIEIPCFGNCSCFSNSIGFLVTADCSNKGWTSIPKDLPETLTFLDLSHNNLSSLRVCDFEKVSSLSVLNISHNVIRSLFSGGESFVDSLRNLKELHLHHNNLSRISNDSFASISTLEVLDLSFNSISTLEPNAFKGLFSLLSLDLSNNSLTLSNHIFPEQVFEDLSNLINLNLKRNLYFPPRSEFDTVGSHSTRTTFFNDRTSFDSSVALQGSIECRNVKCDYPDQALSKLVSLEVLRIDGLKSQYIMGVGFQKLTRLQVLDFGNEGCICYLDRIPELFFSNITSKEPLQVSFTACKIVSVHPEAFSYLPSLSYLSFRGTGNLQFDQFKIASQSLWKTQIKTLDLTYIHRVSFVTLVPDYFIHLRNTSIETLIIDHNVILQVDTRVPVLFPKSIKTFSLAKNKIIVADFLESLFFMKNLEVFNINTQNKYSLEEVPRFSDSEQSEEESISEILSGNRTMFKQLEVTDILNHDETSEGKYQKSATVEEIVLLQKQFCPSYRTNFPSNYQYRHRRLYRELPQADLCLSENSSQSECSSSHIKFEKTFSPHIPFPRKLRELYGKELKLGYAVPPLKILTNVLKVLDLSSNYLYCMEGPFAGFHVLEEIDLSNNYCIALSPYFFNDMPALKILHMAYNGVGFSLEQDWSGRTFANLTQLEYLDLSNNDIHSLSHTLFTSNSFLQTAILKDNALHLFEPSINHLANLSLLDLSKNDLRSLSYQNMRDIDEILETSLLFVDLSENPIQCDCTSLQFLFWYKRRFTVFTGHGKYQCRYEINGSSIYLDDIDKFYWTLWRYCYGWEFFFFTLVLFCLVLIVWISYGIVYFYRYRLYFYLYISKSRYYCNFDDPEHHGIKDVFLVYDDQDPVWRRFVQLVLLPALTDRGVSCYISEVDGAQPEAGRPSRQVIEESVLSGKKTLVLLSRELFYWGENYYNEEKETEVNMAKVCEEVRRDRVLLFLSVEEVPDECVPPHIRQYLDVRPPIRYRPDSPAFWDYLAAKIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KBF3</accession>
    <name>A0ABM0KBF3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger FYVE domain-containing protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101850062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113539.2">
        <property type="nucleotide sequence ID" value="XM_005113482.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850062"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028730">
        <property type="entry name" value="ZFYVE26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46591">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46591:SF1">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="265"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005113539.2"/>
        </source>
    </evidence>
    <sequence length="554" mass="61787" checksum="B23917D1043D1691" modified="2025-10-08" version="1">MNKLAPDTIQEIKKRHLTSLLSGSQPDTVTAFQVLDELLQSSETECLVVCQALANQLSRPNEIKFVLSFILRYLSQHLLPDDVEDLRLRRIGAKALMCIPAKIQDEYSHLLACPHLILEQLLMNMKAELAGQIFEQIKPDFVEVREPKLRMAQEQFNALLTTYARKAVEVTVVQVQEYKSRSESAASSGSGHLEESEMLTSTMRRSYDKRRVSPTLSLASTQSARPDATGRVGMRQKSASATSANTGSRFVMPAQPPTQDQWVPDDATAVCMVCTVERFSMFNRRHHCRRCGRVVCAACSTKQTIVFGVPGRTCDECFEQLHTSSEHRAQEEHEIYSQRIKERLSGAGSGATPTSPGMFASSPTPLDLPGLLSADLLKKNMTAAIQHVHHSWKLRPDTAFSDQVRSEFYFEQAPSVSLCISILKQHSSRLEAGKLTISLCDTLSSHLQPISPGVPNPEIDYSLIISVMKQLLFQAKLDFLSSSSTGMSEQCELYLARVDLLRVMVEANYQDLPTVRELTKQDTVRRLRDKLIADERLKLAMEVSTKCGIDPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUI4</accession>
    <name>A0ABM0ZUI4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glutamate receptor ionotropic, delta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101847637</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012934736.1">
        <property type="nucleotide sequence ID" value="XM_013079282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847637"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="12">
        <location>
            <begin position="311"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012934736.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="46477" checksum="1A135F90AD522194" modified="2025-10-08" version="1">MLDLDLTPCPAVSSTSIHLMPPRHLRSEIMRLLVQKIWKWKEILFIYDNFLDTESMTDLKATLHSLSVSTYLVHVEQDMPSSKLARILKSSINTHYIFVAAKSGVFAEIINQAYPLGTLSKDYKWMIMSDGSCPQLLGRRELRRSNVLLLRATHLQKEAYRLCGRINSFTNSSQIYVRAPWAHLLSAGMEAFLRRSLKYSLQESVLNSRTICDVSLRSKRKKTISTVSNEVIVSNYGDVTFSPDTGSVSSFGYDLCSADDGSKNGYSDVGSWSPSYGLKVDGGSLFKNDFTDFGGRKLLIGSQVVSAVCLYEIVEPPDRLWGAPESNGSWNGIVGMVMRGEIEFGVGPLTITGVRQSVIDFTSPYTEDGIGILTKRPDLDSEAMFRLFKPLQPIVWACLGASIAGVSMLLYLANRYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUT9</accession>
    <name>A0ABM0ZUT9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011082</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934898.1">
        <property type="nucleotide sequence ID" value="XM_013079444.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011082"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012934898.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24197" checksum="4986CA83D825BCCC" modified="2025-10-08" version="1">MVTINAVDQCEADIVSCLFMVMGRVMMHGDTDEKLLAYARSAPVDELCRILESGSHCAQYALDTSCVSQDVDREVYAYMAGVNYACSPEGRQMMATVQQSPCLQDVSLYHQMSRAERNCTSRQREAVDSLTTEGGKGKETPADPDVVCPIIEEMENCMTTNIISVCGATFGQLMDNIVAVMGPSQYGVDCVERRRRESTFARRTLWSLLGQYKERILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUY7</accession>
    <name>A0ABM0ZUY7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011106</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934980.1">
        <property type="nucleotide sequence ID" value="XM_013079526.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011106"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012934980.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="44866" checksum="200C4DC0AF225172" modified="2025-10-08" version="1">MSGSDRVSGENDTLSVHAPSDGDTRDPDVAQALRDNKVTMERILKSLEAFNDRGMKQKWSPSSSSSSSSSSPSSDSSRQNSRSPSPQPNPPKRKGKGLKQVKVPRKSERDRSPSSDSTTATLEARLLSRHGDLRKPSRQSPTPTQTPSASSSNQRESEEIRNSIFNVAGQEFEEDEDTSGPVSEELAEFIHKIFSKTGKGEKLREKAKLYSRPDNCPGLGTPLTNPEIWAVLKGSAKRIDTKLTAIQNLVGKSAVAVAQCADELAKSDPALTKRLIDALALLGHAHKCLTLQRKDRQKYALPSDIRAICDPSVEENAETSKFLYGDDVKKALKEAKESKRLTSSLKADYTPYSFKRRSANNFNKPGRPFLDHRGYSQFPKWKSQGPAHKRGHNSQYRRRKQLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWW7</accession>
    <name>A0ABM0ZWW7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Advillin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101855413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936181.1">
        <property type="nucleotide sequence ID" value="XM_013080727.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855413"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11291">
        <property type="entry name" value="gelsolin_S6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF123">
        <property type="entry name" value="GELSOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="3">
        <location>
            <begin position="745"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012936181.1"/>
        </source>
    </evidence>
    <sequence length="808" mass="92000" checksum="2AC43835E4E65F7E" modified="2025-10-08" version="1">MSVDAAFKEAGQSVGLEIWRIEKLKVVAQEPKTYGEFYSGDSYIILNTKKKKNSPKLEWDLHFWLGKNTSQDEKGIAAYKTVELDDSLGGGPVQYREVQEHESKLFISYFKHGIKYLEGGVESGFKKVERGKYETRLMQCKGKRNIRVKQVELNVNSLNQGDVFILDCGLVIFVWNGPKSSKMERIKAAEAARRIKDEERGGKAAVRIIDEKWETDPAFFKALGSNGPIPAAEEAGDDQEFERVAQETTRLYRVSDATGELEVSEVGGKPLKREHLDSEDCFILDSGPSGIFVWVGRKCTRNEKQSAWKHATDFLSLRGYADWTPVTQLVEDGETPLFKQYFKSWPDRDAQAGMGHVHKKERIAAYSKEKFDSTVLHQRRKREEENLPDDGQGHVQIWRVEHNDLVPQPEDTYGIFYTGDCYIVLYTYRKSGRECYILYFWQGSKSTTDERGASAIYAQRMDDNDLHGAAVQVRVVQGREPEHFLRIFQGRMIIFLGGINNTEPDSAIRLFQIRGTNDFNTRAMQVLPRAAFLNSNDVFLIESDHSVIIWYGKGASPDECLLAKNLTGYLFPDRNTSDVIEVNEGAEEASFWALLGGQEPYASGRQLEGQLSDMPPRLFQCSNASGRFKVEEVVDFSQEDLVEDDVMILDTIDEVYVWVGNGANAIEKKESLQTAMEYIKSDPSGRNPDNTVILQIKQGLEPPAFTGHFMGWDPEKWSQGKTYEDLKRELGQENVGITTVQQELASYDQKHPYSELTKKLPPKGVDPAYKERYLSDEDFQTVFKMSYAQFSSLKQWKQLDLKKKMGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX67</accession>
    <name>A0ABM0ZX67_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101858677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable oxidoreductase that may play a role as regulator of mitochondrial function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with COX5B; this interaction may contribute to localize PYROXD2 to the inner face of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936360.1">
        <property type="nucleotide sequence ID" value="XM_013080906.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858677"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10668">
        <property type="entry name" value="PHYTOENE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10668:SF103">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="254"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012936360.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="62338" checksum="C8F238AC1C577F7B" modified="2025-10-08" version="1">MLRGCGTRFLRNLNNFSGAYSQQCRHMQLKTEYDAVVIGAGHNGLIAAAYLQKAGLNVCVLERRHVIGGAAVTEEIVPGFKFSRASYLLSLMRPQIMNDLELKKYGLKIYFRNPSSYTPLAEPSGLDGKARSLTLGRDSQENARQISQFSKTDAERFVEYEEQLERIVSALDPLLDSPPVSMSALTGSSLREKWSSLGSVKALLSSVRSLGKDVPAFYELMTAPAQKILDRWFESEPLKATLATDSVIGAMASPQHPGSGYVLLHHVMGELDGMKGAWAYVEGGMGGVSKAIANCAQDHGASIFCDKPVSYVDVENNKVRGVVLADGTEIKTSTVLSNATAKVTYLDLLPKGSLPKETVEEVSHLDYTSPVTKINVAVDRIPNFKADPNVKENEPMPHHQCTIHLNCEDSQLIHDAYLDAQQGKITKTPMIEMVIPSTLDPTLCAPGKHVVLLFTQFTPYKLAQGEWDDANRNKYADVVFDTIERYAPGFKDSVIGRDILTPPDLEKTFGLTGGNIFHGSMSLDQLYFSRPTPGLASYKCPVSGLYLCGSGSHPGGGVMGAPGRLAASTALADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXW6</accession>
    <name>A0ABM0ZXW6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein broad-minded</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936761.1">
        <property type="nucleotide sequence ID" value="XM_013081307.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858855"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055392">
        <property type="entry name" value="BROMI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032735">
        <property type="entry name" value="BROMI_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055391">
        <property type="entry name" value="BROMI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF3">
        <property type="entry name" value="PROTEIN BROAD-MINDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14961">
        <property type="entry name" value="BROMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23440">
        <property type="entry name" value="BROMI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23431">
        <property type="entry name" value="BROMI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="BROMI N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BROMI middle region" evidence="2">
        <location>
            <begin position="166"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="BROMI C-terminal Rab TBC-like" evidence="4">
        <location>
            <begin position="857"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012936761.1"/>
        </source>
    </evidence>
    <sequence length="1288" mass="146442" checksum="5BD6027FDB5896B4" modified="2025-10-08" version="1">MSLRGLKGEELKRHLRELVTSWEGIIRDAGSLGQAEETLLHLEENDENFHKHEFVKALKRELEQTLSPLIEDELEKYSTTGHVDSGSHETLVSRITDHIIQSRQYGELKKSLGKNMSEAVDDLLANFDSEFVVGKFGGEVEGLEPRITPLVTDDEEGSVMIFHQDHLKGIADNLGKTKSPEVQREAMQKLNQIISGEIVHNKHWQQLRKNLMDVMADPDQQLSELSLKFVAKSFTCTSHHTSQVYTLLIGFLCSQFSGMNASMPPVKNGLDCSNKTTVKLLKAFRLMIEFQHEAPNYWVRYPMTYLEEIVESSLNLFSLQMVTQAPLTKLSPLHFVAVLDPKAQWFIKWMHGNYSRKILLELLEKYRVIVETSLRHCLDFSAFRKSSLDSMSEVSDAFSKVSVTDHGQRLFYTGPELEYALFIHSLSFLGRLLCFKKGQQFFPVRFREKQVPVSITQLLKALVLLVVDPGMSAAHRRVEKDKDTFEFTTLVTEVLRSLCATEQVCSSIMCRDEIISTLLSPVSQYMDESPDHIPPGEDTLVHVANILCVIASSTKGRRYLLYGEGQSIHSRTKSSSAHQIAEFTKKSLSNTLSKSYVPPSNNVVGVYLYICRQLYNTCEGLFVLSSYELHNSIAQAWKQVQALEKSSSSVASSVKGDELDKYTSESWKGTLQDNLLNFASTAKGILLLHQTGAFNESVRYMYSRYAKKLQVGICEKFGYGYMVTQVAATALGIQALQSTGYIKALLVELWSALECGPQDIPVFTPKSWPVDPIDRASQKHFIRLVNILSAFPAVYELLKGQPLPSRETYSLRDIPNSITALIDRIIFVDSAAKIHSLFNYEQSYTFGLRVLSVMVSCLDTYLLLQSQYKFQEFLLAEQEANKVEDSERFICDVLSVERNYILVKTFLIGGPTERTLPSRTLEEDKSGNLKLPILFSSYPIPREYQPNVAGRSAMKQENELSKFLNASRPEKKAKVWMDKCRNLLHKMLESKPDHAKGNLLQQLLEMSVSHMNQMQEEAIFHLFDFSGTDSTIKNFKLSPLQLLGIKTAVRYGIHLKVINTSSESTENLTQLLKLSGCFLKQQMRSLKTSLQYLEGTYPGFDWFVATIFLIFNGNGERTWNFLHKFSALGCSGYMWMARLHASTIPSGLLSSGISPMFSSTAHNIELLLQTELPLIASAFKMSGYTPSQICMHWLTQCFWNYLDWLDIVHYIVICVVLGVDYQVYLCVAILKHLQRDIFSHMQTQDLIIFLKEEAICNFHILDQMDYMKELEKKYRKIILADMMNITKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY45</accession>
    <name>A0ABM0ZY45_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011493</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936902.1">
        <property type="nucleotide sequence ID" value="XM_013081448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011493"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936902.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39945" checksum="8E925413E123422B" modified="2025-10-08" version="1">MNSSSFVSFILIRGSVSREQYIYLDNIFGMVKAVGEPTAAVCLALSAIVFLLDRKRNATTLYLVALNFAESFNMTMLSVYQLCKITPGCNQRPAYHYANFWLGSYVGISCRRSVQVLNCLVATQRFIAIAFPLRAKTSFLLNHPTLTSLCVLLVSLSFHSYMAFMYDVGPSGARLSGLAIRNYPLFRDLQHSIMYLFMHLSLVLTAAANIGTTVTLVLHKRKMRGVRNTQKTSGAREKNERSMTIMVLVCTALFVVMYLPVSTNQTVADFVSDYGMGTREHYLFFLMNSAFMMCQVLAAQFVFVCYLTLNSSFRKNLVIILFTIFCPLPKCRLCVLASITNKKNGPKRPDIPKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZL9</accession>
    <name>A0ABM0ZZL9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyubiquitin-C isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937811.1">
        <property type="nucleotide sequence ID" value="XM_013082357.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859785"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="381"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="457"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012937811.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="59959" checksum="FE1F8DB7DF75832C" modified="2025-10-08" version="1">MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A022</accession>
    <name>A0ABM1A022_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">StAR-related lipid transfer protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC106011784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938076.1">
        <property type="nucleotide sequence ID" value="XM_013082622.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011784"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043556">
        <property type="entry name" value="StARD5/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46374">
        <property type="entry name" value="PROTEIN CBG07384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46374:SF1">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="13"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012938076.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24995" checksum="635ECCEBF5DE084C" modified="2025-10-08" version="1">MAPSSRSEYEELARAATEKLKEYLTSTDDWKTATKTKDGITVEYKLSDMNEGRNVYRAEYVVDAPLELASESFRWGPESVRAEWVTTIADQKMLEKFSDDLQVVWSLSKSMALGLISPRDIIQVISVTKTEDTFLSSVVSVERDDCPPSDKYVREECSPEGFILERLASDPRKTRLVQVAHYKLNGNLPRSLVEATIPKMMISCFKEFSNYLKKRRSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A087</accession>
    <name>A0ABM1A087_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylesterase 4A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938187.1">
        <property type="nucleotide sequence ID" value="XM_013082733.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864145"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012938187.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17660" checksum="2E2321626921D21D" modified="2025-10-08" version="1">MVDLQTDTMFLVPAVQFARLLLQASDRTDVFLYLFDHYPKLRDPSSPFKGTNHALEMVYLLDKSPIFVSSGMLDYTAIDEPSEEPVFDVFAGALSTFAKTGDPSRVRPNGQTVSWPRYDREQEYYLAIAGDPQTRTRLAAKRVALWTEFLPTMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0U7</accession>
    <name>A0ABM1A0U7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sucrase-isomaltase, intestinal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106011900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938526.1">
        <property type="nucleotide sequence ID" value="XM_013083072.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011900"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012938526.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19977" checksum="E2AF6E8692DED37B" modified="2025-10-08" version="1">MFTYDPENFPDLPKLVNTLRTQNRQFFTILDPVVAVNSSLIQEVQDQFPGYDMLESGNQADIWVKDAANDTLLGEVWAGPSAFPDFTNPASQSWWSRWINFYRALSAGTGTMDVRALWLDMSEPSSFTPGVCGKNQWNYPPYVPHVAGAEKDGSLLSKTLCMDAQLHWGRHYDVHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1B7</accession>
    <name>A0ABM1A1B7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic cation transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012938823.1">
        <property type="nucleotide sequence ID" value="XM_013083369.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852932"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012938823.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="50857" checksum="98A6DE1E65873379" modified="2025-10-08" version="1">MLCIMCIFHSLGRRVSIIVISSLLIVASFASSFIYNIPSLLVLRFLTGVGSVQAYTASYVLALEFLTPVHRNRFNVVLNIMWVLGGFLLTGLAYFVRDFQHLCYAIGGPVVVLVILTWLAPESPRWYLVKGRHEECRKVLERVARINKAPFPQELFQKMIKKNTVPQQKEQLTKQAEGDELVKRGISDGELVAGDACEETTVTVRAGRKENYLTLYKHKDTGIRMLIFVLNWTVNALVYYALVFNVSNMGGSIYVNFAFTNGADLLGLIVVFVVVDRLGRKASYEAFLLLSAVACLATVIPFYFAEPGMTSTIVNILSLIGRFGVSSSFNILFMFSSEFVPTPLRTTSLGIFSLSSRLGSVSGPFIADVGVLLGGRMKEVLPLLVCGIAGLIAFLSALILPETNKQSLPNTIADTKNLIKSQKKKGTPSLGSFVRVTDLDVPVFIPDRGTSEEESRLKLSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1W0</accession>
    <name>A0ABM1A1W0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101860864</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939137.1">
        <property type="nucleotide sequence ID" value="XM_013083683.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860864"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="615"/>
        </location>
    </feature>
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        <location>
            <begin position="722"/>
            <end position="856"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1015"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1597"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1796"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2177"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2306"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2423"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2574"/>
            <end position="2623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2631"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2684"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2780"/>
            <end position="2944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
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        <location>
            <begin position="583"/>
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        <location>
            <begin position="725"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
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            <begin position="2929"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="RefSeq" id="XP_012939137.1"/>
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    <sequence length="2944" mass="317349" checksum="95B42A22ABF2043E" modified="2025-10-08" version="1">MDPNAFFLPSEIARLFVGYFKDHGLVNTLAAFLKESPHLTDYWQLLKNGCVPPRHVMGYSLDQILKEYAVLKAQAARSNTLSGLQPRTPVQLTHTPNTSGVSGSVSVAGQSKQGQRKQRTRTSSGKRKKKQGDNVPGPTCATPVAVPTSSPSCVYSEGTPVVSVCTQGGAQDKAQNNAISLRPATEKFACPGSSKWGTSTYNPEFDLLENVLRQSDIPSKLADSINKALHVVRETEQGTSGNQAAAQNGKEGEAEINIDSIVEMTESDPAFQNFLRVFQHDGAIPVSGFSVTELPPLDNTAHIPDDIQGSLQEVTGSSYQANVPAASDQPAATALEGQGSSLYSANHEQPSTGEQLNAGSQPLLHTGDQEGSHHAVTQTTVTPLHPRAMVTSLQPPSTISSLDPHTMVTPLHPHTMVTSLQPPTTDTLPQPLQPPTVEGHHLTTSPVGQPCEGSTYPDLSRSRDFHGLQDSGENSYSVQGVVSNQHEPVPLPSGTQAQGCSDIITEDANHQVINNESGGFQLVPSSQGENGSHDSVTHPVESENSVQSLLKTAKDASEEPETVENPASVNISHENPTSKNRHISGDHSAKTESFNKPKSARKLPSPKRYGSGHSRFGMDDNSLSVFSLIEKKVADMTGETFVHRSQRASQHSVGGEGLVEGASTVPVSKVHSEVRPVPETDREENSFSGVFASSLETSDSVAVNPKCSTTFKTVCYTDADEKSVRSSGAPSQSHQDVRSPVDKTSEDASDRIPSPDHMDEVPSSPDFVDEPNRDSDSLSSSSHNDNDVRKQQEGAISSQERRSNLDNRELSGKESAKSSSSVDRVGQSCEPRRLPLFPSSFERGSGKGKMSNFGKSLENLKSDSKLNCTSKTVKCVENSGHYGCSVTLSSPPGARDGTSPKQITTAQLMSTSLPADWAKPLDDDVFKSPRSAFRALIDQSEKPDSFLWTSASTVRLDTGRAKSVFSVNRGHTPFIPEHCKKVPSRRIAPIEVSYSTPSPLQELPASPMNFVIDGPPSEPPSPLERVGEVVEPGSSKTSKSFQRHVSESSSALEKLGIRMPLSPSRRKPRRLVPTQLRTVKGFGSSFLRKMSTDFHFDDAKTVSSSSDMTTASQSEEEAFRQLKSFLSTSYSKPQPQQEITSTSPSRKPSKCRCSSIDTCKHRKGKLQRALLATVLEGRDKTPASREVTERITPTTDIPVHFVSEKVLTDRVSYGLAEKPPSNNTSQADGEKESEHNDCPRITSADGIRTPQQEDPSLNCPETSSAEKILTDNLSCCVTERPPSNASQAGEEKESERNEGAGRTSTDEVRQQQQEDPKVNCLETSSAVEGSAVLNYLRKESLMSLSQSDSSRNSSFAAVGVIEFCSDAAAKRDSSLREENGTKAGQVSELHAENLPNFTEAPESVYASENYVTPLPSVTCVAASCSSVAPPTTTYSTASASEAQISASGPFTSLLNQPVTPANVSSLMTNEQSLSGFISGALRVAHNIPPEQFPIQTSSFPEQGLAVDSSRYTDGGANHDYSYPLPLTVSSQTLQESQGEEVHLEDISHRSPVLSLPAGQDNVNASGDFHIETSKDNGGPSYEKNSWGHEMSVGMLEQSGQFSPHPRTSGVCSVTSAPQAAKSVRSSRRSKKSLTNTSESQARKSCFIVPKLVEKSTTETELEKIQLQQLSNANNFPKILPKPLPGVVCNTVLKDIHVVTGDNQQLVIVLPPDYQELLQDVVPGTNTASPVSEHTSSPGVAHLSSAQEVQVQYQQENPHGLSLCVNPTSVTSSMLSPAIPVNSSDVSRFVETPADEVGTPLVTTNSNHKSKVLTQSSTEKPSCAKMNVPWPDLEEDFVPPVSSVGSDNLTEEEMLSARETTKRSRKKSNTKQKSAEKIRSVSKDPGEKPASKSLSASPGKGQGPLNKSDSTVQKAKKVLSIGKKAEMAKISPKNNPKVTSASDVSKQDKQASKGEKTLDQGNISGGLSPMDLSVKKPGDSENKMSGRKKGSGSKGKTGLSKHQGKDEKKNENISKDKRNEKDSKETNVSTEKLVSKKKSKSAITPSKQKLQSSKKYSKSVIKFQFESPGKRDQNQSAEQRSSKKRKMGDRESEDPSPMKQPCNSKRQKVESDSCDSPNAPGPSSVNFSNILKKGSSSKKGAALQQIQEKLNSSESDLKGKRSLLKTFEKVAADCALSSAEVEEDCLDSHNKDEYSGEATKVSQKSKLKDRTKKLSNGSSGKRNKVGEPPPPSLSPSSVVMDDDEAESAPRKCVPPRRITSQYVTVKEDNCGGDVIQIGPALQESFFYCTAMRRKSVSLTSLAGDHRAQGSSLENETTFHTPSPPLQTNAESNVQKNLQGSQRRPGKFTRLSLSSSNKTKRPEADTGKAVQKNAGETPHIPGNTKLLVSMNRNERFECSESTFVKSIPKSDLQSIIASVGFQLSQAQDRHTEEPAGSSVSGGMVNEKREGRKRRKQLAPQPFKGHNRIDPTERGGKIKLRLPIRQGDEPTSEPKKAAHVPVCGPDSNTKNVPEDARNTGNGVDGVTQGQGQGQLRDKSSNVQEQMVDAVSDTSPQVVTNVPDVETAAAVAALRFSMGDESVQEPLRSENQTETHYREDQQQQREGIKLTPGGHRSNSPDIVPSSQVISNIQTSVRNYPMSTSSPTKNLPPKKRLSTEALYPASLHDAYLRSPTKSDQFDFRNVRFSQSSSGAGNNANQSDELRPPFEQISGSHSQLSNRANSFGLKLSSQLEDTALDLSKRSTEASFSELRKLTTVTRTDTHAIPEIQLEPSFVNNERTASTADGVSANTGGNEPQGFTPLVPSSSSLCQATTGQSRQDGFVTKESSDHPQSRKPSQTDDVIPDSLPSPGDRNNPNRRHSSVGGSSPRTKWQSVTSDSSYRSEENGSDQAITSARQESTSAEGTGVQASPAWSNKSSPGSSLPISQSKIAKLVRKLHRTKKDNPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1X4</accession>
    <name>A0ABM1A1X4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate sulfotransferase 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101853565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939155.1">
        <property type="nucleotide sequence ID" value="XM_013083701.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853565"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052654">
        <property type="entry name" value="CS_Sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723:SF0">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012939155.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52826" checksum="A4CC6848461F5091" modified="2025-10-08" version="1">MGDIDPPVEEILEDKLGHEFLTTLCLEKGSRPCSLCLAWPARSPDLSIHNRVPGLTVPPSEDPSTTRRPLLSPTLGNDSNSYRQVTPPYLPEFRNPCWRQEGDKRRLLCVPYVFLAGFPKSGTTDLHSRISAHPLVSVFSRKEPHYMTRKVFKHVTCAPGHEELARTSCEILTYARTFYKTVALDILRRGRKDWSVDSSASTAWDNCHWTSLQAGHNCTDHSEYYMMVPALIARMNPHTRVIIILRDPVDRVYSDYAYFHDNTSQAAFHSSTETFVQRFWDCRRHSSLKTCAFDMVSYVSAGGGDVAIVLLVMVPFPTGLEARGQIPACAGPSHVTDHDRQTDRQTDRQTNCLQNVLCQTGLSGCNPALPRPPLVPTPPLHPSLPPSCFFFSLSTAPLTDEALGRIERAKEKNTNTHAKASLGPMWEETRLMLQRFYQPHNAQLAKLLGDETFTWRYNSTLETMLLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3T0</accession>
    <name>A0ABM1A3T0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lengsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamate-ammonia ligase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101856109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Dodecamer. Interacts with BFSP2 and VIM.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940250.1">
        <property type="nucleotide sequence ID" value="XM_013084796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856109"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407:SF1">
        <property type="entry name" value="LENGSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="133"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012940250.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34089" checksum="DCDDD1E0A8D18E02" modified="2025-10-08" version="1">MLQDRLCKVADWCEEYKVVINPDKAQVIWCSLNNRIVKDSTPEIVFDHVLIDRQHELKYLGITLDRTLSFRRHIDNVAVRAQKGINLVVLSVIDYGLGILSLSKTQIDRLERVKNAAMRAVLGCTKDTHVVCMRYTLDLASIRVRHKVAQAKLYLNVLGDPRHPLHENQGSIKGNRIKRGSSWLAEAEDSLRKDFFMELLNELKQMNVLTETLQPETNSDFFEVTLDVAEGIKAADGTALFKSHVKTFSKRKGYVASFMSKVDKTAYFGIGLHFNHSLWTLDGANMLLDDSNEHQVYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A487</accession>
    <name>A0ABM1A487_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cathepsin L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101855655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940521.2">
        <property type="nucleotide sequence ID" value="XM_013085067.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855655"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046764529" evidence="7">
        <location>
            <begin position="18"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="110"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012940521.2"/>
        </source>
    </evidence>
    <sequence length="327" mass="36509" checksum="333EEB8217622756" modified="2025-10-08" version="1">MFRFAVALCALVAVSSALRYDRNDLWSAYKTTHGKLYSGQREVLRREIWESNLDYIQRHNVEADRGMHTYWMGENQFTDLTNSEFRAMMNGYQMSNRTSSVQFVSTLTDTPDAVDWRDKGYVTKVKNQERCGSCWAFSTTGSLEGQTFKKTGKLPSLSEQNLVDCSKKEGNKGCKGGLMDKAFEYVIKNNGIDTEDSYPYTGHDGLSCKFKKADVGATETSFVDVKRGSEEALAQAVAEIGPISVAMDAGHESFQHYRTGIYKEPRCSSIKLDHGVLAVGYGADGGSNYWIVKNSWGTMWGDQGYFKLAKDDHNMCGLATQASYPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4W8</accession>
    <name>A0ABM1A4W8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012446</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940894.1">
        <property type="nucleotide sequence ID" value="XM_013085440.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012446"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028027">
        <property type="entry name" value="SPMAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34221:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34221">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC691189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15075">
        <property type="entry name" value="SPMAP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940894.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27294" checksum="74E30AB8845C5BEB" modified="2025-10-08" version="1">MSGNTSNTPSGLSETSSQQMKTPRSTNGASGQPTRGNTRNTKLKTVSRNTTPVTPRSWVTYNSPLWRKDCVKSKEQLSHSMPTTPRILSRMETGFVNDAINTHILSSRRNPIIPQYDALSDKYAQAYFKSPFVQGIMEKNNALVTLKDLKSQRTVNKLSVRRRCKQTPDVNEIRQRETRFVNDAIITEKKRNKYKDIIPPYDARDDKLCKAYFQRGDIKRLVDRTCSTRTTHPQKGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4Y4</accession>
    <name>A0ABM1A4Y4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ATP-binding cassette sub-family D member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101850581</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67073"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940917.1">
        <property type="nucleotide sequence ID" value="XM_013085463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850581"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005283">
        <property type="entry name" value="FA_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00954">
        <property type="entry name" value="3a01203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF62">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="119"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="452"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012940917.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="76258" checksum="005220FBC81E71F5" modified="2025-10-08" version="1">MAAQSKLNALLHPSITPKNSAIITAAGIAAYFVYRNVSKKARKRRGAEEEEVKVVIAQHGHRKEKAAVDSVFFGRLTNILKILVPGLFTPEAWYLLLVAFSLVARTYADVWMIGNGTSIERAIIGRNGEDFKNLLFKFIYAMPAISTVNNILKYGLNMLKLRFRMRLSKHLYDRYLKGFTFYKMSNLDNRISNADQLLTQDTEKFCDSVAELYSNLSKPILDVILYSVKLAGAIGVMGPTYMLLYLAASGLFLTRLRRPVGRMTVSEQKLEGEYRYVNSRLITNSEEIAFYQGNTREKFIITGTFQKLVEHLRNFIFFRVQMGFIDNIIAKYLATVVGYLVVSRPFINLDHPRHKNSTHAERFEDYFRSGRMLVKMAEAIGRIVLAGRELTRLAGFTARVTELMRVLNDLNGGRYERTMVNTDNGGRGSSNNLKAMTLKPGSGNIIIKDRIIKFDKVPLVTPNGDVLIEELSFEVHSGKNVLICGPNGCGKSSLFRILGELWPLFGGTLTKPEKGKLFYVPQRPYMAVGTLRDQVIYPDNHTEQLKKGVKDKELQEILSKVQLGHILDREGGWDSVQDWMDVLSGGEKQRIAMARLFYHKPQFAILDECTSAVSVDVEGFMYQHSREVGITLFTVSHRKSLWKHHEYYLKMDGRGYYEFKPITEDTTEFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A541</accession>
    <name>A0ABM1A541_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101862665</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012941002.1">
        <property type="nucleotide sequence ID" value="XM_013085548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862665"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045036175" description="adenosine deaminase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="12">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="198"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012941002.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="58285" checksum="A12494B6844EB69F" modified="2025-10-08" version="1">MFKGYVISAAVGTTFVVLVLWLVCSSVAGMPSQYAQERKKMADKERSMRLGSQLTLNDREEMVNCYLMSLKQFMIATSTAGKTLFPPSQHFFHTKADIDNSTLFHIIQMMPKGGSLHLHESCMTSLEWVIKNLTYMDNLYTRMEESGEVRARLYLFSQASPGTEWTLMSELRAAQTDVDRFDQELLDTLAMWGTEPYASNHEAWNDFHAYFRGIDGFLTNMESRRLYDLHGIEEAYDDGLQYLEWRVSANNTDMVEYIRMLQGIVKDFKAEHPDFLGVKVIFEGMRESTPATVSDNVRKVANAMKLFPDEVKGYDLTNEEDVVNRLEHFVDVLVDDEGTALLPYFFHAGETTWSGGADMNLLDAVLLNTTRIGHGFATVKHPEVLKAVMERPIPVEVNPVSNQVLALVRDLRDHPASSMISYGAPVVISSDNPNVYFAKMQSHDSYAAFMGLASQQDDLRLLKQLAINSLKYSAMTETEKTDAFAAWQIRWDLFVEEVIAKYNLESYCQKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5H4</accession>
    <name>A0ABM1A5H4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine, alanine and asparagine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941212.1">
        <property type="nucleotide sequence ID" value="XM_013085758.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012536"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941212.1"/>
        </source>
    </evidence>
    <sequence length="625" mass="65125" checksum="57070BB6C516F24D" modified="2025-10-08" version="1">MSCVRFSLLSPADIVEFVEPNTSLFTGTVGRDMLVSIYRTHMMILSGLTPTPPEPPRNYQSPPTFPGSGSLYFRPLEYADTRCSQFHFNIQSQLNSQQLLFNSQQQSNSRQPLSRKPEEDKALTQPRSEVVEPASSWGKSPCLPCEAKLMSADEDTQKTGSGGKGKGGEDDGGVGGVGGGGSSRNGGSGREDEGGDSNSLGSRSVCGGGGGGSGGGGRGGGSGGGGGGSGGRGASTAAASTSAAAAVSCNAEPERKTITIRTPERCEGAQLDLLLTPKVSERSLTLGSETDDNSKGREGGDSNEMTSSSKDCAKDCAKDYATDCAKDHAKNREKDCFKDYAKDCAKTRTKDCIKDRARDYAKDYSKDYTKDCAKDCFTDRARDSRRFTKATSEVPGRRGRSSLERSTTSRGSCGCENPGDDVIDRSGFPGRSGPSSLVTRGRLKTPCHVTGFSHVSAREGGVTSRLRSVRSGRPTRCTAGEQGAGPGVMSRVSSGRRFGYGTRIGGGGGGWERGGRGGRGCGVCDSVTSRNGATTAPPPSLVLLVQAPRGPAEVTSSSVEAPGLQEARKTSRVSFDLTPSYDLQDSGLPRTDTPPTTHDTLDTLSRAAVLLGGEGRAGPKEGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A617</accession>
    <name>A0ABM1A617_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860221 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941524.1">
        <property type="nucleotide sequence ID" value="XM_013086070.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860221"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF2">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045432285" evidence="1">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="2">
        <location>
            <begin position="69"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941524.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22905" checksum="23ED7B4AD56E3D08" modified="2025-10-08" version="1">MWRALAITLCLTCYLWTVADSSAVVEKRGDLSISRSQQEMVKIVQRAIMFRKDAAQYGSVPGMSPNNSCACVNYTCGCCLHLEVEKIHLNDTGCVNISYLPEEYGLEVDVTLDGRIVYQKKISAKNPPPVCAPIPYVHKLADLCIRFYNLSVHGKQFSGCADIEFTLEGITVKTFNIGCFQIPPSRQIQMIKIMESVVLSEASLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8D4</accession>
    <name>A0ABM1A8D4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106012941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_012942788.1">
        <property type="nucleotide sequence ID" value="XM_013087334.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012941"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012942788.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31256" checksum="8CB61F6966C6ECA2" modified="2025-10-08" version="1">MSSVEQIRVIQLPKEVDVFHYHRMQYSSVLHQGQRSKILLARSQIIPDKKFAVKQMPLLSDEDRDRFSREMWLMKLASDIRGVVTLLPRPVFCGPNGYLIMPFYDKRDLLSRTGKLSHDNWMKVFVRAAVSLRSLHKKNIYHQNLRPENILLNTRDVAFISDFGAACLLSEGCDKVDTWTAAPGFRGPEADKEDGQLCTFQLDTYSLAVSMWQVLSGLCPVKNKPLDHLDNIPPQYAALLRNLLLPDPDMRWTLDKFLTEALELHPDLSCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8X2</accession>
    <name>A0ABM1A8X2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106013020</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943079.1">
        <property type="nucleotide sequence ID" value="XM_013087625.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013020"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943079.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="20679" checksum="3C37CF81F4F1F140" modified="2025-10-08" version="1">MNDDADFGSYTCIASNTLGEGAQIKFNVQEVGGPAVGASTDEGLSTVTIILIAIIVIILLIIIVLLIIFCCLQGACGRAKEKGKVAPTPPPRSVPMYGGGHFGPTIAPHSNGTIKVDEEAGFTPKEEMLATGLIISVPEKAGGRAHHLPPLDTHKDVENYYREERRRSRKKKYRRTQEDRNVLTEPNGDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A913</accession>
    <name>A0ABM1A913_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013031</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943137.1">
        <property type="nucleotide sequence ID" value="XM_013087683.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013031"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943137.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="47613" checksum="028574FA76F0E2EA" modified="2025-10-08" version="1">MRAFLYAFWLVIIERKKKKKRMNNNYTIIFFLSCFSAVCFSVKTECLLDYTPSEEFLEGEYEGWTGPTQGGHGGPWGRPGGVAYGPGGRGMDQEDWKEAMGMDEMEDYPGHGYAGQGYAGQGHPFQGYELSPTAMSGHQRGGRFLDEEGEWEDAKKKRRRKRRRKRTPWALNRGMSRHSPGTLVGKLTCAQGAMIHVLNVSLGFSDTSHCWPARPGCQAGSATAKQIIHCQGITGSCDVTVRRHHMMRCGRGVNYAAISYECVPAKHKVDICSSVSRDEEGSVLISSPSYPSSPSSVTPTASASGDFMTCECTLRTVEGSRFEIQSLRSVFLLSSLFFCFHKYVCLYNTENAVRWKGYKLSVKSINLPITECFFLSHAKSKAKSKAKSKAKSKAHETGVTYSKNLNRWVTGKDKDNLVVLNMQIGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9H8</accession>
    <name>A0ABM1A9H8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-N-acetylglucosaminidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106013110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943397.1">
        <property type="nucleotide sequence ID" value="XM_013087943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013110"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="1">
        <location>
            <begin position="122"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="2">
        <location>
            <begin position="325"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943397.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="60372" checksum="14DF0E7B20C96169" modified="2025-10-08" version="1">MTRQVSGQSTFVLAPAVVEDMTHAGCERPQDKAREDRLNIFKKIQNVQPREAPVSTVSCALCVYHYFPQLSHVSTKTPAHVQGEAARDVIRRLVLDRASDFEVKVDQNMGPRHRDTFKPPSSTPFTREPEYIRSAGSAVYKGMIAGDPDAVWLMQGWLFLDPFWQAPQVKALVTSVPIGRMIVLDLASELSPVFSRFESYYGQPFIWCMIHNFGGTNVLYGAVEQINVGPFHGRRFPNSSMVGIGLTPEGINQNEVMYEFMLENAWRTEPRDVDQWSVDDGNLVKVGLGHQQKLSDLCNILQSVAEAQFRELRRSPVGFGLSTNWVVSFARQRYGADNTAVTRAWRRLISSVYNSTKAHFDFNNVLITKRPSTSYDVGSDIWYKPRDLFQAWEGFVNASPDLAESQLFQYDVTDVTRNSLQVISLYHYYVMMSAFQGNDPAGVQAAGAKISELLTDMDLVLSANDRFLVGRCIADAKSWATDADEMRLLEYNARNQITLISIMRPSSGQDSLQSDVIAISQALFAKYRPITLHPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9L2</accession>
    <name>A0ABM1A9L2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic cation transporter protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101846769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012943446.2">
        <property type="nucleotide sequence ID" value="XM_013087992.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846769"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012943446.2"/>
        </source>
    </evidence>
    <sequence length="525" mass="57719" checksum="F8A09501BC054116" modified="2025-10-08" version="1">MICSIPGLPNDSYVAVDEAHASLINVSLPWDSELGDKGGWSQCLVRSVDEGTGDQVNRECTAWVYDDSVFRSTVVSKFDLICDKKMSRSHARMILMGGLLLGAIGIGVIADIIGRKKALMAMVALHAGASIAVAYVESFVLYVIFRFLTGISISGLFLAIFVLGMELVGPSKRMFVGIVVEVFWALGVMILGAIAYFVRDWNYLQMAVSFPILLFFSYWWFIPESPRWLLARGRDEEAEAIIRHAAKVNGVKMPDKIFDGKTFDEAYTREKMSRVFTSPRFMFRLVVLCYNWLSSAMVFYGLGLNAGNLAGDLYVNFELMGVVELIAYGACVLLLNRIGRKPLHIACMILGGGACLSTIFTVLYADESLQWLNIVLALLGKCGASAAFAIIYVYSAELFPTPLRNSLMGVTCLFARMGGMISPYIADLNTVVSGQFGQALPLIVFGASTVAGGLMCFMLPETLHKHLPETLEDATNFGRVTSSSSGTVRRRQGDWDIEYTVDAPSKECDPLNARTRDREAKEPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA04</accession>
    <name>A0ABM1AA04_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Argininosuccinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943688.1">
        <property type="nucleotide sequence ID" value="XM_013088234.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850366"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012943688.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12517" checksum="CCAD3772491F140F" modified="2025-10-08" version="1">MIIPDLRQDFVDDFIWAAVQANATYEDRYLLGTALARPLIAKAMVKVAIEEGAHYVAHGATGKGNDQIRFELGAYALHPSIEVISPWRLPEFYTTFPGRKELFAYAEVRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB31</accession>
    <name>A0ABM1AB31_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101849325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_012944307.1">
        <property type="nucleotide sequence ID" value="XM_013088853.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849325"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="228"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012944307.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41437" checksum="91B29E226ECF1BCF" modified="2025-10-08" version="1">EVRKEFRNVTSFYYQSAIDAAALQPSVRLTPAAILYSGKSPDQSHILRSCQYLHKELPVRIAHRINGFRNLPFIVGCHPTLLSVHELYIRAFHILSDFGPIRDLDQERQWSEALRNLLDDHKDVVTQLAEGFSECRKYVSDEILIKSFLDRTLTSRLGIRMLSEHHLALHDEKPNHVGIINVAFSPRKLVEKKADFIRGVCEAKYGAAPSVKINGHANATFPYIQPPLDYILGELLKNAMRASVESHLSGVGIPDVTVTIANNDHHFVFRISDRGGGIPAKIAKKVFDYNFTTSGSTTDDRVDGGIFGQIMQAEHTGPAPGKMHGYGFGLPTSRAYAQYLGGSLTLESLEGIGTDVYLRLSHIDGRSESFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB41</accession>
    <name>A0ABM1AB41_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FRAS1-related extracellular matrix protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101852125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944319.2">
        <property type="nucleotide sequence ID" value="XM_013088865.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852125"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF8">
        <property type="entry name" value="FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="57"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="182"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="303"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="423"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012944319.2"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129297" checksum="F8127B09D90E7E8D" modified="2025-10-08" version="1">MEVWIIIDKKCLSLFTGQTEKTWRLRLKDDDRYEQLETFTLKLSDPVTAVLEYPDIAEVTIEDIEDESKVFFSNKEYRVSEDIGEILIPVTRTGDAHDETMVICSTVQDTARGTVPSTVTSFSDYISRPNDHRSVLRFDKGEREKFCRVTIIDDSLFEEEEKFTVILSAPMGGKLGELETTDVIIEPDKNDEPAFYLGNSEYVVDESDGFLEVKVWRTGTDLSRPSSVMVRSRKSDPKSAEAGLDYVAVNRILDFAPGVTMQTVRLVILDDLGRPRLEGEETFSVVLKMPSDAMLGEPRRAMVTINDSVSDLPSMQFKEEAYKVSEADGEVSAVILRSGDVSHTSSVRCYTRQATALVALDYEERPDTDASLVVFQPGDYAKECKVKIIDDNKFEDAEQFRLVLGTASSEELGAANIGEADSTLITIEDEGDQPVIKLSASSYSVKEPLFQEQFTSVTIPVLREGDLSETAIVTLNTKDGSANAGKDYNGFFKELTFEANMSRVEVGVDILWDNITEMREVFTVHLRYASGTAKIRNHKATVFIEERKKVADVTFPAKPMVMSLRDYDQLDVTEDDLPVQGYPLVCVTTCNPKHPDYLKTGALCVSEGINDTLTLFRWRVSAPTGQDGVTSDLQNVESNTFFATTKGITLDSIYFSGGSRVQCGARAVNTDGDPGLELLSEAETIDPDSGICEPRVMDSVGAEPFTAKMRYIGASDPDHPNKVRLTIIIPHRDGMMPVISTRQLSNFELTLSKDGTRLASHRCSNLLDFNEVQTEFGFINNQTKDPNIIGETEPYQYSSRLRTEPTLRFYRHLDLESCLWKFENYFDMSELLTDCGGQINTDGQVLNIKQSYVSMRVPLYVSYVFHSPVARGGWLHYDMTSRLQLTFVYDTSILWQNGISSSSADGDTGMQGYMYPTSMRLDDEGKLVVSFRTEARFRGQFVATHPGSSLESMVMSSDHPDLTFSLKLIRSDPTFDQPSQEWSFQSDLSVRDYSGQFNVQLIPCTTSLDQEYSQPISCSPREPIGFELPIRFQQVSDPVPAEFSLNTEFHLMRKRELWLSEEDHDIGDETDIAFLPTDKIYGRINVDPIQNLGNSFDLNVEKVFLCSGTDGYIPKYDPDNLEFGCVAESPNLQYTFKILDKGAPFTAVNKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AB54</accession>
    <name>A0ABM1AB54_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore complex protein Nup98-Nup96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101860697</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944343.1">
        <property type="nucleotide sequence ID" value="XM_013088889.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860697"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21240">
        <property type="entry name" value="Nup98_GLEBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="13">
        <location>
            <begin position="759"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="58"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="616"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="956"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1051"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1072"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1084"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012944343.1"/>
        </source>
    </evidence>
    <sequence length="1954" mass="209924" checksum="531C3199FC25B099" modified="2025-10-08" version="1">MFGANKSAAFSSFGTSMSSFGNFGSSAGGFGSGSTFGSTAPAGSGLFGGGGASGSTGATGGGLFGGQTNTGFGQPQSGGGFSAFGGTPNTSGGLFGSNTSQANTGGSSLFSSPATSGGFGGQKPAFSGFGGTTNQASTGGLFGAGGGTTTGTPSLFGQASASGAFGNAGVASGGTTVPFAAPTGQDTMMKNGVTTNINTKHQCVTAMKEYESKSLEELRAEDYTANRKSKQAPSASSGLFGQTPAMSGGGFVFGTGGGGLGGSNLQSGTSAGFGGFGSTSSAATTPFNQNRPLFGTSTTTQSGFGFGTATGTQQSSSLFGNTARPLFGGTASTQPSLTGGTSFFGASAAGTSNPVGFGANTGSNLFGAKPGGFGTATTSSLGFGSGGNMFAKPTTTASSFGFGTNTSTSGFGGTSGGLFGMKSGGFGGASTGLGSGTSFGFGSGLGTNSTASTFGTNAAKPGLGAFSFGTGTTGTAGFGSTLGGAAGAGTFNLGGGATTLGTSTASSQANSTQHLLALASSPYGDNPLFWNVKQQNKEKREDVLKPTNPNAQKAVLSSANQYKVSPRPSTRIKPKSLHNLINGGKTQLFEGLEEEDFSFGDDTFVPRKSVKKLVLRKGAGNKSTSASSSFYSDTAGDNTLQFNGNSNRSNQMPSLITKPLSPSERVDTTIENEAEAIVHDQDRTPVHRSPPKISSLEDSIVALNQKGPAVAINTSRTPEANNRLGAADTTSFLDTSDLDGSCWVVDSSSPHPTGVVLTRPGYYTIPSLDEMIDLMDENGNVFVEDFTVGRVGFGNVFFPGTTNVAGMNLDDTVHFRRKEVVVYPDDDKKPPLGEGLNKKAEVTLDCVWPTDKSTRTPIKSPERLKVLSYADKIEETTAKIGAKFIDYRPETGSWVFQVNHFSKYGLLDDSDEDELTEQQKKLLAGQHVKEVILVQKLKIQAQQQLQQKELAKKGKLAADQGLTPEGMQEAAQREKEEEMQREEYEEEDGLEEEDSYDMLDAEDMQLKKRFQDEGTLPSLGLNFGFVYVFMPPQKKKKLKIQAQQQLQQKELAKKGKLAADQGLTPEGMQEAAQREKEEEMQREEYEEEDGLEEEDSYDMLDAEDMQLKKRFQDEGMDTSVDSKYLATSMGVSARTIQGMKASFFGDDGLGGMPVKAKKKEAVEKGDMDIFEDLQSMWKKSSDKTSSNLFGAFKHPASLSLPQSPAFSDSKDSYGKEGYEPVSFPKAGLFDMGVSKDVLRPTPQTFLHPPVMEHKLISSGLRPEDAPPRILGTRVRHSIVHPRDSVLYRNQQSLVDAACFTGRSFRVGWGPSWSFVHTGFAVGLQDEESAEVSILPSLRGRVKSLPRLKSWQAVMEKLQVYDYMDQRSHAVLKQQEELLEVQLDHSLMEVEDGAPLMVPEPGVDALHKLVRAVEEGKVDLASSLDGPVQEQMRMVLGLCVALWGNLPDAADLDKDDLYVRRQLRREAVSQWLSETSSSRVASEMEAAPIISPEDCLGAVFSKLTVREISEACLLAQRGRDHRMSLLMAQAMTGQAFRQLMAAQLDKWAELNACQFVKELRMKIYCLLAGELVWATKDLTVNTCKGLDWKRALALHLWYKCLPGESIQQALAQYQKGFRGSKESQAYCAAPVPPYLEGENLGDEEIFDTAYHLLCLFSDKKYPLEAVLSPSSSTASHLDFRLSWHLLQTLESLGYRHLSPQCRDTIHVSFASQLEAQGLWQWAAFVLLHIPSAVQRQKAVQSLLQRHLGIGEEMTERERFLLDKLHIPAQWLHQAKAIRAGLESNRAAEARHWLLAGQYDKAHTIVIRHIAADAIINDDYNYLRSFLEKMALPEHSLSILNWASSGKVFLDFINIRERLELLKQQEPTPYDLEELEPEVRSLCSRVKSLTCLNAKDRLCQAEMSKTAASVLRTFRDLQGKLSVRFLTEHIPDLPMPEDYKLQELRAITQARVLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABY7</accession>
    <name>A0ABM1ABY7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Suppressor of lurcher protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101850916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944785.1">
        <property type="nucleotide sequence ID" value="XM_013089331.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850916"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF2">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046725074" evidence="4">
        <location>
            <begin position="22"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="173"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="314"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="454"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012944785.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="72049" checksum="F9B693B6C1F1499D" modified="2025-10-08" version="1">MRVGLAVLVIHMTGLLHTCTSINPACDCVVYQSHGLSSGRFTSPNFPQYYPSNINCVLYTFIGDATEIIELTFIQFDLKMPDPSGRCFDFLRVYQNLERPEVNEHNQHDMEFCGGYNSIQSTIYSSGRSMVLEFHTEPRSGRPGNYTGFKGIYRFLNKANYITTGIRAQGKQCTYDFHSNSSHISGRFFSPFYPQHYKASTSCRYHFHARQGERVRIMFTNIQLHHIDASPSYYSCRDSPDVITVYDGTDSQAPVIGQFCSVRNSEEVVSTGSELVVAFTSDDRNQKQGFAATYEFMSRVIKPKGPKSIPEFQCNENINSRHHRNGTISSPNYPSAYPAPITCRYIFTGVGRERIQLRFLHMDLHFPSGNPAEPIDCSGSDSVSVYIIINGNTEKLNTWCGRRLPPMLMSSQHKMVVEFKSFHSSPAVTGFKAQYSFVTNFGILEGQQDNRGTCVFNYQSTVQSTGEITSPNYNGQYPRNTECHYLFYGRGKERVHIQFVDFDVDGINPRCEESTNSDYVSFSNFAETEDRKMTRLCGTPSKEKREIWSDGPFFRVIFKSNDIYDSTGFHAYYQFIGPDVETPPQLLPKPSDDPRRNAASSSVYPSRSGYLPLAPHISLTAAVCVVVMLLSQCAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE55</accession>
    <name>A0ABM1AE55_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G-protein coupled receptor GRL101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945963.1">
        <property type="nucleotide sequence ID" value="XM_013090509.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860467"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012945963.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="46338" checksum="CCC339438BE65737" modified="2025-10-08" version="1">MLLALSQLTSLSSDNYKLCCPVMKPKSLSTGTCQAPKDEISSCEDILRTPFFRVFLWLVASLTILGNSCVLVYRLCVERKPSTLGYNTFVTNLSASDLLMGIYLAIIGAADQVYKGRYLWEADSWQNSSYCSLAGFLCTVSSEVSALTICMVTLDRYLALAFPLANVHLTPKKAQCLVLVTWVVGVLFAGVPLLPPLSHWRFYAQTAVCVPLPITRADFPGRDYAFSVFILVNLALFVAIAVGQVLIYRSVKANSRKMVAAVSSRRNQDATIAKKLALVVITDFLCWFPIGVMGILSKVGVPIPGEVNVVATIFILPLNSALNPYLYTLPAVKKKLEQWKAKSHENKAGSAGFRLRSIDLPHRDVSSGSTQFESVCSDSSMSAGGAADVIKAQACLDKLRAWLETGRISRERVTEILSHFQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFA6</accession>
    <name>A0ABM1AFA6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101862705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012946559.1">
        <property type="nucleotide sequence ID" value="XM_013091105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862705"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012946559.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22056" checksum="806AEF72621927F7" modified="2025-10-08" version="1">MKTVDQQNVLLDTFNLVRGPRLGRGGSGEVVLASAKHDPSLKVAVKMVSLKRKSGETDFFNEVSFLRELRHPHILKMIAFACVPQHGLILMTYYQNGTLSSLILSEPLKGRRMLGHVLDVTCALEYLHNRYIYHQDVKPLNILLDNQDRAILGDFGHAKQARESSAKVREWVSTPGFYGPETRKGRPMCPFKVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFV4</accession>
    <name>A0ABM1AFV4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106014203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106014203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946837.1">
        <property type="nucleotide sequence ID" value="XM_013091383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014203"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reelin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946837.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13444" checksum="15BBD3998802BE2F" modified="2025-10-08" version="1">MCFVRQLKNVSGHLFSFQSGNGVTHTNNSVKSSVEFNWEAPDTSVGPIVFHYTVVRGGAPNTTVNPADYFMNVVSAPLNPATTLLRFTSEMEAQDRGNGVRVMEVSEQLSLREILLRKHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPF6</accession>
    <name>A0ABM1VPF6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">LOC101850633</name>
    </gene>
    <organism evidence="16 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005093106.1">
        <property type="nucleotide sequence ID" value="XM_005093049.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093107.1">
        <property type="nucleotide sequence ID" value="XM_005093050.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824298.1">
        <property type="nucleotide sequence ID" value="XM_035968405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850633"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="165"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005093106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005093107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035824298.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37932" checksum="2F0CD7DDC460CB18" modified="2025-10-08" version="1">MRMSRSIEYPSEKNGEPSCIEAEQRSGETKMLKSEQSQDEAETSDWSENEDSHSGKLDANSCKGKLAAFLKTNLVQYSIIALVILDCLIIVMELLIDMNIIVFPEDDPHHPPGEGSSHHPVAFASRSSNLTGDNHTVYPAHHIHTHHDNSSNLTMYGNDSAHAAPVHHHTNKEKAEHVLHALSLTILSIFMVEVCVKIYVEGKHMLKQKAEVFDAIVVIVSFTLDITFSFVSVSKAASEAAGLMVILRLWRVTRIINGVIMSVKLDANKKMEVHKKARRKLERENKRLQAKIERLEREVATLKQKMATSSTPQMSFEMQSGLSVERSPSGEMRENSAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQH2</accession>
    <name>A0ABM1VQH2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101846203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035824664.1">
        <property type="nucleotide sequence ID" value="XM_035968771.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846203"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="74"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="733"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035824664.1"/>
        </source>
    </evidence>
    <sequence length="995" mass="112908" checksum="3106CF423D21207D" modified="2025-10-08" version="1">MRNLQVGLLNRLKVIPILPCSKWTLRFKGSVSKPEKSKRYANTLNLPQTLFPLSMKHGAAAQRELEIQKTKEFQNLYSWQRQQNWTEEFVLHDGPPYANGKTHVGHTVNKVLKDITNRYKVMKKCKVHYVPGWDCHGMPIEVKAITDDMGQHQKLSPLEIRAKAKKFAEGVIREQRKSFMRWGIMADWSKSYLTMNPQYQEKQLEVFYKIYQKGFVYRNYMPVYWSPSSGTALAEAELEYNPEHVSKSVYLTFPLLTQPKVEQLDKVSGATVHAVIWTTTPWTLPFNQAICYNPGIRYAFLKCARSSNVYLCEESFVEKLKAIVGGDLELLCNVDGHTLEGTVYKHPLNQQELPFLPGEHVLPGKGTGLVHTAPAHGHDDFQVAVRNDLPLECHVDAQGRYTSGVDSSMVGKVVDDDANEAVLSALSKNVLQVENFTHSYPYDWRTKKPVIIRSSQQWFIDVSALRDQALECLSEVKISPPQSEGGMVSQLQSRPYWCISRQRTWGVPIPVFYHKESGEPLVTRETVDHLKELFRTQSPDCWWTLPVSELLPDRLLAELGKGQSSDYSRGEDILDIWFDSGVSWASVLAEVGGQADVYLEGIDQFKGWFQTSLLTSVAVNGRAPYKQIVTHSFATDEEGKKMSKSVGNVTDPEEVINGGKNKKTSPSYGVDVLRWWVAHSHHHQQIQVGPSILSRFHEDVFKVRKCVRHLLGNLFDFEPGVHSVPYDEMTAVDQYMLYVLSTTMQQIDEAYESISYHKVIQNIEKFVYSDLSSFYINITRDRCYCSDIDSKVRRSSQTVQYHIARTLTSAFAPVMPHLAEEIFQYIPGHDDADSDTDSIFKLGWCTPDLAWNNPDAAHRLMPVFDIRRDLLEELGTESPVDFDTLIYSSPQLHDLLRELQPETTSSTSPVCEVLQTSQVTILDKAPRSIPDDAVILAGSTRIQGSVSDTAEEVDYKVLLMSAALNLCERCRRYTATSSRAPCDRCMNSLADDWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQT9</accession>
    <name>A0ABM1VQT9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118477430</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824781.1">
        <property type="nucleotide sequence ID" value="XM_035968888.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477430"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035824781.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13999" checksum="48177B7C353E150F" modified="2025-10-08" version="1">MEADYAVLLKSGCAFSSRSPSLGQIIDCSFFTASSGSSIRSDHRAMSEYVNDKCLRVGMSREESVQAYNEMAPDFNEYVGGIKYIAPEKAADLTSELFPDKSKEKILDLACGTGLVAEAVSFVKKKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVU2</accession>
    <name>A0ABM1VVU2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Uncharacterized protein LOC101846548 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC101846548</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005090193.1">
        <property type="nucleotide sequence ID" value="XM_005090136.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826534.1">
        <property type="nucleotide sequence ID" value="XM_035970641.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846548"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="51"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="561"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005090193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035826534.1"/>
        </source>
    </evidence>
    <sequence length="729" mass="80637" checksum="924D1AF4222228DD" modified="2025-10-08" version="1">MANLTDYIPGSGLDNLTLNSTGDSSTPKWSFEFSVTLATIMSISALVNVVGNSMVLTVIIRHRGMRTRTNLFLVNLAVADLFVGVLVMPFSIITLIKGAWIFNDFVCKLNGFLTCLCLVTSFHTLMYIGIHKYFSIVRPLRNPLKLKMILAMMAAAWVWAIVCSILVVAGLVVEYKRGTSQCGPKYPNDLQTFVIHGIIQISDLIMPFLILVFCYSRMFSAIKEHSTRLRNHTTVEEDVILSQQKKVTITMFIVLACFIMMAFPYFLYATYVTIKKDKDGFSSVINPLAYAFLYLNSMCNPIIYAFRSPAFREGYKEILCQTPSYVISDESPIHAMPCPRLPASPDSEHPHRTGRFSSIVENLRRGSSLSSARHSITNSLMLDPDAASLPGGQLGQKEKQQKRRLSKQKSLFDLLRSTRQSNAQSVVQRNGDTIIMKGGKIVSVRRGGDVKEGNPFISKLKTIKDAAAAKSHGLAVGLAGPGQVMFEVSYEGVEDSKAMGQRDSMDTESRWSDDVFMTDRCSADRGGAGRHGVYSKADMHSRTLYNNDEGFHELDPKANKDATTKQQNLPSGSSELKVQHQNSNNNVSKNPGSEFGTNSALNTRLDSLGSRSNISSPRRSSVPIIAVSDMDGELSPRPLSPDRHPHLTKSDTNLSPTRAPNGISLTNPRFPVSRSSNQIFRKPVFARLPSLEYLDPPTQIIKSFSSASLRLLKRKSPDKEMSSGAEETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVY9</accession>
    <name>A0ABM1VVY9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118477942</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118477942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826581.1">
        <property type="nucleotide sequence ID" value="XM_035970688.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477942"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826581.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17547" checksum="B06B25FBED59A07B" modified="2025-10-08" version="1">MVALKADDLVIKRFPNLTRIESEVPAAEVAGIISGGITVIVFAAVIGVLCWRFPSCRSRSFWDKNIKRALRKVYGKCKKKKVKEEKKSLIIGPMIRKRSRDEPPFVVPQIFVDYGSRRTSYASASDHMMLGALALDLRRSSGSSAGSRRTSLASDSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWZ3</accession>
    <name>A0ABM1VWZ3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructokinase</fullName>
            <ecNumber evidence="4">2.7.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC118478097</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035826935.1">
        <property type="nucleotide sequence ID" value="XM_035971042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478097"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="14">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035826935.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16498" checksum="84EF40C94513CACC" modified="2025-10-08" version="1">NACLGSSSLTAKEIGFERIAKAIKQLDLSGIILLGGFDAFESLHQFWQAKSEHRELCIPMCMVPVTITNNIPGTEFSVGADSALNEIVNYCDKMKRVARGRTNCVFVVEVPMGKKNWPDLNGSQTSEVFLVYPGETKKETNRRAWSAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXY7</accession>
    <name>A0ABM1VXY7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium- and chloride-dependent glycine transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106012599</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827280.1">
        <property type="nucleotide sequence ID" value="XM_035971387.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012599"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035827280.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9480" checksum="B2E0158A41E7BDC1" modified="2025-10-08" version="1">MANCKFSSMDKRRDSVDSSSSSGGSIAKMKIEEDAAARGGWGGKLDFILTCIGYAVGLGNIWRFPYLCYKSGGGGHPPAHHGVHHVPGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZB1</accession>
    <name>A0ABM1VZB1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118478381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035827754.1">
        <property type="nucleotide sequence ID" value="XM_035971861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478381"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827754.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20460" checksum="7F1C065C960469BA" modified="2025-10-08" version="1">MAGCTFSAVMHAEGMNSCDKIIMDKCDRELGGRGMEEENETPSVDVLVEKSGGCGKYQIFIVFSTLTGKFFIVWGFLGDSIGRKKTLFGSNFLCCVFSVVAIFSVNWEMFAAVRALIGATIGSHLAVVFPYPMEFVPRTHRSLLCAIPTWNLGTAAFAILVWTLKDWRYIHVATAITMGLCSIGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0Z8</accession>
    <name>A0ABM1W0Z8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuropeptide Y receptor type 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101859201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828341.1">
        <property type="nucleotide sequence ID" value="XM_035972448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859201"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF22">
        <property type="entry name" value="PROCTOLIN RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035828341.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53467" checksum="B997EF116A314E61" modified="2025-10-08" version="1">MASLMLLEPNVYAKNLTMTSSTPLEFLGNASDGTDVITSLQTTRFIVQTVLTPIIVVVGLLGNVLNILVLLQPNMRSSTNVYIMVLSLADSVYLAVNLALSFLACAKRGLPDFAYYFNPYGRFASNFSGNVAVWVCVIFTVERYVAVCHPIHGKIWCTVRRARFASLAVSALSLVNTLPTIFELEVVESSDGLRCRYTQFSQSDSYELGYTWWYVTLFTFIPLISLTIFNTVLIRALLLANRKREQLTLISIHSSSSSTSNGKGCYGNKKTTVQTYGHASLRNQISESSEVTSSGVRSSSTSSGRGASRVTLPTTPLLQNKTTSSSLPPPQLQQQQNHHQPHNQQLQQPQNQQEQSRTSGLLPATAASPSSSCSSSQKRQSRKLAREQNKVTLLLVTIVMIFLLCQLPWTALFLYKTYLSSYNLPSSSTELKIAGNICNLLGLLNASVNFYLYSCFSRRFRRTLAKLVFCCRRWNNSPTTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W104</accession>
    <name>A0ABM1W104_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118478584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828347.1">
        <property type="nucleotide sequence ID" value="XM_035972454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478584"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="146"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828347.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35351" checksum="7C3FE58A866E77D9" modified="2025-10-08" version="1">MAERQVSEKDNDPVTSEDIHSVSLTSSTFSVLSRYRKFLLQKVKARKPRPPLRCYARLVIICARLCKQSLDNLAQARGEYESVMQVLDEYGARLSWGGLVFSPADYRATKQQCLNVGARKLLQQDPATRTEQDINVLLVALRNIPAFAEYPKKMQRQLCRVGGFETFEPRRVVLREGDPPSSFYFILSGAVLVTSFDEKSGTSRTLVQLDKGMSFGELAVISNTKRQATVCSKTEVELLSISGEEFQDIFMAGGKNIMANAKQQEFIRKGVAVVHLGSTHKRGLVLFSGNFPESTVGVVDSRSIGELILTHREIPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W196</accession>
    <name>A0ABM1W196_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylthioribulose-1-phosphate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828439.1">
        <property type="nucleotide sequence ID" value="XM_035972546.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857904"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828439.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19665" checksum="9E27AEA639CDD13A" modified="2025-10-08" version="1">MPKRPANTDVSTDGTDFAELDDEHPRKLIPSLCRQFYDLGWVTGTGGGVSIKQGKEIYIAPSGVQKERIQVSFFVLCNYRYDEELVVPIIENTPFEEDLKEEMFRAMQDYPDTCAVLVRRHGVYVWGDTWQKAKTMCECYDYLFDMAVQMKGLGLDPTETPTPPKGAYVSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2A1</accession>
    <name>A0ABM1W2A1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calpain-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118478737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828794.1">
        <property type="nucleotide sequence ID" value="XM_035972901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478737"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="86"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828794.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15893" checksum="A461D1DE036B0193" modified="2025-10-08" version="1">MASKDKPFKGQLYGKLRRRCLSKRKLFVDGEFPPTGSSLFFSRPAPADIVWKRPKSWLRWRAPKLGDFQNWEVKILAIGGGVVAWGIFHFKFWRCGNWVDVVIDDYLPTRNGRLIFTHSKSRNEFWSALLEKAYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W497</accession>
    <name>A0ABM1W497_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">RNA binding protein fox-1 homolog 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101845599</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005112980.1">
        <property type="nucleotide sequence ID" value="XM_005112923.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829490.1">
        <property type="nucleotide sequence ID" value="XM_035973597.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845599"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12407">
        <property type="entry name" value="RRM_FOX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034237">
        <property type="entry name" value="FOX1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047131">
        <property type="entry name" value="RBFOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597">
        <property type="entry name" value="ATAXIN 2-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597:SF22">
        <property type="entry name" value="RNA-BINDING FOX PROTEIN 1, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="163"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005112980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035829490.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="41967" checksum="6AC60667F9C1342B" modified="2025-10-08" version="1">MMKMIVKGGLHPIPGLPRLRHEIPSVGGVILTKHMVQNQMTPTYATYPQATSLDEYHQAVANQAAAAGSAAAAGLAGIQNVAGVNVAVSAITTEPSAQTIYTTTPVTTNGAAEQQTALLREAHKSLWLRDIKAVSETELPSSESEATAIPPTSGAISPNTGPKRLHVSNIPFRFREADLRQLLGQFGTILDVEIIFNERGSKGFGFVTFANSGDADRAREKLNGTVVEGRKIEVNNATARVMTKKVTAPTLSTDSVAAAALRGVALTRGRTAAAVAARGLGGVYTAAAAAAAGLRHPTPIAAPPTAIPYAASVYQDPFLTYDPARYQLVTSQPYPAAAAAASYPTGAARYAIPAAAVATPVTYTAAGYGREYAAEPYIGHSIGPVAGYGATVYRGGYQRFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-02-09" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D2CG73</accession>
    <name>D2CG73_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC100533215</name>
        <name evidence="9" type="synonym">inx</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2006-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning and distribution of pannexin gene family in Aplysia californica.</title>
            <authorList>
                <person name="Ha T.J."/>
                <person name="Panchin Y."/>
                <person name="Moroz L.L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2022-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Carter C.J."/>
                <person name="Magoski N.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="12">Neural ganglia</tissue>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EF015585">
        <property type="protein sequence ID" value="ABM54566.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="OP047927">
        <property type="protein sequence ID" value="WET20650.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191461.1">
        <property type="nucleotide sequence ID" value="NM_001204532.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939600.1">
        <property type="nucleotide sequence ID" value="XM_013084146.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D2CG73"/>
    <dbReference type="GeneID" id="100533215"/>
    <dbReference type="OrthoDB" id="6156233at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABM54566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WET20650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="NP_001191461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012939600.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="48563" checksum="C1A5488A920AEC28" modified="2010-02-09" version="1">MGFFRRSLSEDSVDRYNHIWSVLLLLALALTTWLLPLSPAIGSLALPDPVSTRPSADTSEPKLPTYRATCWTPIEFTNAYVKFANEKCAAALNTVVKSGNASRSLYLNMDNLPPTFDRFDDHYVKPEDIITGRNEMSDQTTQRPTRQTGQSSEARADSYFFVAVTVPLLLFVFAICLRLPHLLWCLMSSCGALNVEQTLDSARQGLMLDASSRRQFHSDLARAAKVAAGASRGVGLAYLIFKFLMCLVVVCELTALGVVLLPELNDLKDRNVRNVSEPDVSYSDVLASPAHYQYENDIMFLCDFKIRQLQSVQIWTVQCMFSYDPSSAALLSSLDDGRNVRPIGDLLQGYHALLTAVLAYLIILFVVDFLSLVTWLSRLVFGTCRDSLTDGGSTLSLDLSFLLLMSKEHNDPLVTSALGQHLMVGSSRETEMEKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M4W621</accession>
    <name>M4W621_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neuronal acetylcholine receptor subunit alpha-10-like precursor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Nicotinic acetylcholine receptor subunit type P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101853242</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="J. Neurophysiol." volume="112" first="446" last="462">
            <title>A potentially novel nicotinic receptor in Aplysia neuroendocrine cells.</title>
            <authorList>
                <person name="White S.H."/>
                <person name="Carter C.J."/>
                <person name="Magoski N.S."/>
            </authorList>
            <dbReference type="PubMed" id="24740855"/>
            <dbReference type="DOI" id="10.1152/jn.00796.2013"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="KC411664">
        <property type="protein sequence ID" value="AGI03856.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001267743.1">
        <property type="nucleotide sequence ID" value="NM_001280814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M4W621"/>
    <dbReference type="GeneID" id="101853242"/>
    <dbReference type="OrthoDB" id="410315at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5 10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022249406" evidence="5 10">
        <location>
            <begin position="29"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="42"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="272"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGI03856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="NP_001267743.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="56889" checksum="62BC7DBA929851B3" modified="2013-05-29" version="1">MAVLTLRCCKAVFVLVFMVLIFSQQCEAGQPTLSGGREVWHEEELIKHLLNGYVKEARPVLKPEDTVEVSVKFSFVRVEDLDEATDTFASSVFIVQVWTDPRLKWDLSKYGGVHTVRLPASKIWIPDLVLYNVAHREPPSSLYEETVTVTSDGSVVWVPMLTLYSTCPMDLSNFPYDVQTCRIVFGSWMHTSWEMNVTFISKEKAEMDVVLSEEDSSYLVHQHPQWELVGNRAKARLTLKKYDCCQQPFTLITISVQLRRRSQFYRYLTLGPAAVLGILVPVVFLVPARSQDKTTFGLLLLLTLTVLMSILQQAVPFNHGSMPRICSFYLGTMILTSISVVASVIVANICVRGARRKPVPAWAHSLFLGRGSLRRFLCIGDFGPVRNLYSSDISANAAASGIHLADLSRGEGNEPTLQEVEGEGLWWVTDQLLNNSADGSSESPATSGSAEDKKWSQLACYVKFIVGKMAADSAYENANQEWEELGRVIDRLLFIAFFALYVFTAAALL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1988-04-01" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>P07712</accession>
    <name>AGN5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName>Abdominal ganglion neuropeptides L5-67</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName>Luqin</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>Luqin-B</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>Luqin-C</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>Proline-rich mature peptide</fullName>
                <shortName>PRMP</shortName>
            </recommendedName>
        </component>
    </protein>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1986" name="DNA" volume="5" first="203" last="208">
            <title>A neuropeptide precursor expressed in Aplysia neuron L5.</title>
            <authorList>
                <person name="Shyamala M."/>
                <person name="Fisher J.M."/>
                <person name="Scheller R.H."/>
            </authorList>
            <dbReference type="PubMed" id="3013547"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Peptides" volume="16" first="331" last="338">
            <title>Processing of the L5-67 precursor peptide and characterization of LUQIN in the LUQ neurons of Aplysia californica.</title>
            <authorList>
                <person name="Aloyz R.S."/>
                <person name="DesGroseillers L."/>
            </authorList>
            <dbReference type="PubMed" id="7784264"/>
            <dbReference type="DOI" id="10.1016/0196-9781(94)00140-5"/>
        </citation>
        <scope>CHARACTERIZATION</scope>
        <scope>PROTEIN SEQUENCE OF 24-33</scope>
        <scope>AMIDATION AT PHE-33</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Peptides" volume="19" first="1425" last="1433">
            <title>Mass spectrometric survey of interganglionically transported peptides in Aplysia.</title>
            <authorList>
                <person name="Li L."/>
                <person name="Moroz T.P."/>
                <person name="Garden R.W."/>
                <person name="Floyd P.D."/>
                <person name="Weiss K.R."/>
                <person name="Sweedler J.V."/>
            </authorList>
            <dbReference type="PubMed" id="9809658"/>
            <dbReference type="DOI" id="10.1016/S0196-9781(98)00094-1"/>
        </citation>
        <scope>MASS SPECTROMETRY</scope>
        <scope>PROTEOLYTIC PROCESSING</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text>Neurons L2-4 and L6, also called giant dorsal LUQ (Left Upper Quadrant) neurons of the abdominal ganglion. Also expressed in smaller neurons in the CNS and in peripheral organs such as the kidney.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">The prohormone is proteolytically cleaved in 2 steps, yielding first 2 products: luqin and PRMP. In the second step, PRMP is cleaved to yield luqin-B and luqin-C.</text>
    </comment>
    <comment type="mass spectrometry" mass="1200.8" error="2.0E-4" method="MALDI" evidence="2">
        <molecule>Luqin</molecule>
    </comment>
    <comment type="mass spectrometry" mass="8555.0" method="MALDI" evidence="2">
        <molecule>Proline-rich mature peptide</molecule>
    </comment>
    <comment type="mass spectrometry" mass="3221.9" error="3.0E-4" method="MALDI" evidence="2">
        <molecule>Luqin-B</molecule>
    </comment>
    <comment type="mass spectrometry" mass="5354.0" method="MALDI" evidence="2">
        <molecule>Luqin-C</molecule>
    </comment>
    <comment type="caution">
        <text evidence="3">Was previously thought to be expressed in L5.</text>
    </comment>
    <dbReference type="EMBL" id="M13649">
        <property type="protein sequence ID" value="AAA27764.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="A25458">
        <property type="entry name" value="A25458"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191480.1">
        <property type="nucleotide sequence ID" value="NM_001204551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P07712"/>
    <dbReference type="EnsemblMetazoa" id="NM_001204551.1">
        <property type="protein sequence ID" value="NP_001191480.1"/>
        <property type="gene ID" value="LOC100533239"/>
    </dbReference>
    <dbReference type="GeneID" id="100533239"/>
    <dbReference type="OrthoDB" id="6071613at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016535">
        <property type="entry name" value="RFamide_neuropeptide_ACEP-1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008109">
        <property type="entry name" value="RFamide_neuropeptide_ACEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0027">Amidation</keyword>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0527">Neuropeptide</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001788" description="Luqin">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001789" description="Proline-rich mature peptide">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001790" description="Luqin-B">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000001791" description="Luqin-C">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phenylalanine amide" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="7784264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9809658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="112" mass="12447" checksum="A110C859028958C4" modified="1988-04-01" version="1" precursor="true">MKTAVLLVCLAYVMAAILSLCASAPSWRPQGRFGKRTIPDRLPQTEESSLPDFGFSHLPALPLELFYNPRDLVHSGFRPRLCSVSGVEGYPPCVESHSDRKMKNLLDDLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAU7STS1</accession>
    <name>A0AAU7STS1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Tachykinin-like peptides receptor 99D isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Tachykinin-related peptide receptor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC101851938</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2024" name="J. Biol. Chem." volume="0" first="0" last="0">
            <title>Two C-terminal isoforms of Aplysia tachykinin-related peptide receptors display phosphorylation-dependent and independent desensitization mechanisms.</title>
            <authorList>
                <person name="Guo S."/>
                <person name="Mao R."/>
                <person name="Zhang G."/>
                <person name="Li Y."/>
                <person name="Xu J."/>
                <person name="Wang H."/>
                <person name="Fu P."/>
                <person name="Liu C."/>
                <person name="Wu S."/>
                <person name="Chen P."/>
                <person name="Mei Y."/>
                <person name="Jin Q."/>
                <person name="Liu C."/>
                <person name="Zhang Y."/>
                <person name="Ding X."/>
                <person name="Liu W."/>
                <person name="Romanova E.V."/>
                <person name="Zhou H."/>
                <person name="Cropper E.C."/>
                <person name="Checco J.W."/>
                <person name="Sweedler J.V."/>
                <person name="Jing J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="PP823911">
        <property type="protein sequence ID" value="XBU08368.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936179.2">
        <property type="nucleotide sequence ID" value="XM_013080725.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012936180.2">
        <property type="nucleotide sequence ID" value="XM_013080726.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAU7STS1"/>
    <dbReference type="GeneID" id="101851938"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15390">
        <property type="entry name" value="7tmA_TACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00244">
        <property type="entry name" value="NEUROKININR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="94"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="XBU08368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012936179.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_012936180.2"/>
        </source>
    </evidence>
    <sequence length="447" mass="51133" checksum="95F89C11F966F0A9" modified="2024-11-27" version="1">MELNPTLPFNGGPLFRPDLFNLSNYNSSLDASSANGASGVLSSNSSVGDSGINSTAAPSNCTDGCGENRYILPWWQQSIFITMFVLMFIIAAGGNIIVIWIVLAHKRMRTVTNYFLVNLAIADVMISIFNVLFHFTFNLYQDWFFGLEYCKFAFFIASCTISVSVLTFMAIAIDRYIAIIHPLRPRLTGRIVLTIITIIWLMSILLALPNLLYATMYRYDNGRHVCYLHWPDSVAGEASQQDLAYNILLMVVNYFVPMITLAATYLRIGWELWGSQAIGEAVPMQAERIRSKRKVVKMMIAVVVIFGVCWLPTHLYFILSSIHKDIAFLPYVQQLYLLIYWLAMSNSMYNPIVYCLMNARFRQGFLRFFRFCPCRACRRRHHLLVMERGFYSTRMSLGSERGEKNGSLLHTTVESLDDHVSTPTASMYRMHPMSTRGRNNHHIQRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBC7</accession>
    <name>A0ABM0JBC7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo repeat-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089754.1">
        <property type="nucleotide sequence ID" value="XM_005089697.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849336"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089754.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="52030" checksum="848CAC5553577EBC" modified="2025-10-08" version="1">MAKQISQKTFDDVVRENMREFEMEAEEAVQDAIQQFESQGVNLSIIVKDPSLYTESADSGDTHDHPVVTAVKKLDACLAGPPGAAQDEIVSCLQDVQKECDTDLSRRCLAGSNGAYDVLYKALCTYEKEPDTFRLVLSSFCALVNGQPDLIDCKGIELLMSALKQYRESAETEELIVRAIRLNCVKHEANRQEFVKHDYIITATELLTAHKSNPTLVKEICISLRTLTLDDDVRVPFGKAHETAKTIVTEGDALKAILSLCEEHLNNPIVLAELFLTLSCLAVRNEFCEEVMNRGGLKLIIQAFESGIKDKVIVRQALIVMKVLAGNDDVKKEICKLGGVELVVTAMTTHQNNSHIAEAACKLLTAITLRNPENCRKVVDCHGHQHIVQAMKLHPNEVGVQKNACMSLRNLVSRTKDLSECILALGVEPLLNNAMNCHKEAQDEAKAALRDLGCKVELQELWKGKRGTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JD91</accession>
    <name>A0ABM0JD91_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Serine/threonine-protein kinase par-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101857537</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005091034.1">
        <property type="nucleotide sequence ID" value="XM_005090977.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857537"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14080">
        <property type="entry name" value="STKc_TSSK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF102">
        <property type="entry name" value="TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="299"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="660"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005091034.1"/>
        </source>
    </evidence>
    <sequence length="747" mass="81859" checksum="F149848045FB34CF" modified="2025-10-08" version="1">MGGATPMQVSAYLHARGYRLGPRLGKGSYAKVKVAERLADRHIVAVKIVNRRRAAKEFLDKFLPRELSILLSLDHRNIIKVHEIIQLEEVVCVVMEYAGAGDLLDFVKRRGALAETQAGPIFAQVCEGIRYLHSRHICHRDLKCENILLRLDLTVALSDFGFSRTLPSPDTLSQTYCGSAAYASPELLRGKPYFPLLNDIWSLGCVLFIMVTGQMPFYDKNTKKMMYRQLKGKVNFPEDRPVTPQCRDVIGHTLEPNMDKRYDIGEILEHPWMAPYVRTLDHTSEDTPERGEQSYEFANNRVASGFKPPEYETGVGKTHPLSGISALQEQSYERAEHGVSPDNVHRDVRHSDAGNPDTEHPDTGNAEIGVVDDPNPRQSSRLSYSSVDSEEDHTTSGTAEIRSLCRMPGEACILRGLGHKSHALSRIEDMGSETDQTSPGHGGVCYVIQSQASSSSVDSAASYAVSSSTSIDPAPATTSPRPLLQEEKPYGLKAVQQRDAGGSRGVANRTAERGGLDQNFKMNIQKILQIPLKASARLLSPEMINHVVSKGTSPPHIDKSRGGCMANTTGAPHVLSDPPVGYMPQNSSSALPTMGGISTLAQSPLSPSATTNSRCSGQPKINGGTIAHLSINSANQNGISLQHPVPKNQNQAVRCLHERLPSSPRPVDQSESYTTSQSPPRTKNQPIEYAANTQDSRTSKTKEDLAISEESIRVHEEGLVTQMRRIFESKDASTAMSQRRTGTWGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDM0</accession>
    <name>A0ABM0JDM0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15 16" type="primary">LOC101845899</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091257.1">
        <property type="nucleotide sequence ID" value="XM_005091200.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005091258.1">
        <property type="nucleotide sequence ID" value="XM_005091201.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829205.1">
        <property type="nucleotide sequence ID" value="XM_035973312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845899"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="725"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005091257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005091258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035829205.1"/>
        </source>
    </evidence>
    <sequence length="843" mass="93225" checksum="12F284BF88B89C6E" modified="2025-10-08" version="1">MNVLKAVSMPAPKRLRDLIREIRSSRTAADERAVVNRECATIRDSFRDQDNTYRCRNVAKLLYIHMLGYPAHFGQLECMKLIASPRFTDKRIGYLGAMLLLDERQDVHLLITNSLKNDLGHTTQYIQSLALCTLGAICSTEMSRDLAGEVEKMIKSSNAYIKKKAILCAFGIIRKVPDLMEMYIPATRSLLNEKNHGVLLTAVCLITEMSEKSPDTLHHFRKVSAQTANLVPQLVRILKHLIMAGYSPEHDVSGVSDPFLQVKILRLLRILGRNDAEASETMNDILAQVATNTDTSKNVGHAILYEIVLTIMGIQSEAGLRVLAVNILGRFLLNNDKNIRYVALNTLLRVVNADYNAVQRHRTTIVDCLRDPDISIRRRAIELSFALINHNNVRGMMKELLSFLETCDPEFKSDCCSNIVIAASKYSPNKRWHIDTVLKVLTTAGNYIKGDVVTIVIQLVSETSSLHAYSVQQLFRALRVHYTEQPLAQVAAWCIGEYGDLIHSHCLEDEEPLEVSEDEVISLLEKVLANNNSSVVTKEYSITALMKLSSRYTKSSQKLKQVLAQYGSSTNVELQQRSVEYSNLFGKYDHMRPALLEHMPLIEAHPHSLEDQFSEGQDEVNLLTDAVSRANAHNNATITPPAENGDILDILSNGVSQPHGPGAETSKSGGGGGTTDFLVDLLGDLTTDTPAAPTGTVLSPASNNNLIDGFMQSPAPTNNVMNGMSSLPPVTAFNKNGLLVEFLCQRSEAVQTVINMKATNSTPFPMTDFVFQAAVPKSFQLSLQSPSGNVIAPINSGSVTQVIQLNNPQKQAIRMRLKISYSHNGATVDEMGEVNTFPAELWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEZ5</accession>
    <name>A0ABM0JEZ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand calcium-binding domain-containing protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092189.1">
        <property type="nucleotide sequence ID" value="XM_005092132.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858388"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF60">
        <property type="entry name" value="CALAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005092189.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25397" checksum="2916C75829253C2C" modified="2025-10-08" version="1">MTSRRKFQEQFIQNMLKNHKSDSERPCHFSALEITSLLELFNKFSGTAGHKHRLERVRFRDELHKSFQITDDFLMDRIFRAFDKGSKGYLRPEDFICGLSTLLVGNLEDQMKYCFQVYDLNSDGYISREEMFHLLKSTLVKQSTEEDPDEGVKDLVETALKKLDCDHDGRVSYPDFKQAVTQDTLMLECLGTCLPNDKSKKAFLQLIRGEGGCEMWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGJ7</accession>
    <name>A0ABM0JGJ7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093194.1">
        <property type="nucleotide sequence ID" value="XM_005093137.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850871"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046256829" evidence="1">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005093194.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11301" checksum="D70E2498E1D235E0" modified="2025-10-08" version="1">MNAKMLLLGLFMTLVVFNLVSEAQGQGAEGVEGEGLEVPSEAEIEETIGEALSELANEPGLSVAKRGWLKKKTKKVWRKVKPIAKQVLIHILKNMAQGKRSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGL0</accession>
    <name>A0ABM0JGL0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosomal protein of 290 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093228.1">
        <property type="nucleotide sequence ID" value="XM_005093171.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858391"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005093228.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28394" checksum="3D2BAA2250435B95" modified="2025-10-08" version="1">MNLHDIHSCSKAAAENVELRRKLALLKRKYDELQHQIKALVQEKTSESAKSCQRTFQNSCVQTDSKPWMFRHGQGLTVQQERKVSDSDIAKTNKVLEMHAQLLKRYDKEVKLNMTYADSISELNIRLAETEKSLREEKEKSTQLERELFAAKRSLGEKLKGKGRVEDPVLRDVVEERNKLLKENKRLRGELKGFDHNFFDEIEDLKFALLQSAKLNSSYEKSLRDLCSKFGVPCPVKETRQKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHK1</accession>
    <name>A0ABM0JHK1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras-related GTP-binding protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101850703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093813.3">
        <property type="nucleotide sequence ID" value="XM_005093756.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850703"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005093813.3"/>
        </source>
    </evidence>
    <sequence length="408" mass="45057" checksum="5381AD5E30E85596" modified="2025-10-08" version="1">MSYEDDQGGTYVGSFPKGFGYGPDEADTDSAASPGDEKPRILLMGLRRSGKSSIQKVVFHKVSPNETLFLESTSKIVKDDISNSSFVQFQIWDIPGQIDFFDATFDSEYIFGGCGALIFVIDAQDDYIEALSRLQMAVTRAHKINENIKFEVFIHKVDGLSDDNKIETQRDILQRATDELADAGMDNIRLSFHLTSIYDHSIFEAFSKVVQKLIPQLPVLENLLDIVISNSKIEKAFLFDVVSKIYIATDSTPVDMQCYELCCDMIDVVIDMSCIYGVRDDGAFDNESASFIKLNSSTILFLREVNRHLALLCILREDGCENRGIIEYNFKCFRNAIQEVFVARNKQTPKSTGHPQMDKLVNGSDESIGNGLGDLGGQAIGSGAAVGSGHSHLNGSLGNQFGDNALDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHN1</accession>
    <name>A0ABM0JHN1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101861794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093863.1">
        <property type="nucleotide sequence ID" value="XM_005093806.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861794"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005093863.1"/>
        </source>
    </evidence>
    <sequence length="656" mass="75751" checksum="D696C08352120846" modified="2025-10-08" version="1">MATAGEREVEEFLLPVPRREHVGLHCVWGMGKQLHLFETQVPPACSSGKQIPQATQRDQAIFDVQWNAEMHDIARKLVNETHNIFVMLQGQVKSMTESMLFTQLKKASKQYRAVLKACSMELMQISDDCRNEIHKLKYEEHIQEFEMVQLIWSLCEIIFIDVAPGGLILTPLLDWLQWHFPEGKQLAMEVTQAEVPSSHPSYWEAVYRLLLQANTESVRKLLSLHPYSHSDPFVSVDELLQKMPHWTHQHAQFAAEYEMKWRHWREECVRRYEAGEFAAYEHLETIVQILCGDEAVFREMKNRCETWYHMLVSKLLFQNPTARLNDLGSDIKTCQSMFGQPTGQVRELDNILQAAMEFDIHQVIKDSCSFLSNRSWWFVSHLADVLHHCGQLDPQKLPFGSNLREYLLLEYATGLMSHESLWQVGVDYLDFCPVFGRSYLASYIEHIPLDTERKAHKVLHMCQERDMGAQAQSICKVMGMKCLQQQRLGSALSWFLKSKDATVIKQITEKFLNEYCEQGKFSHLDLIDHLGPSMLVANSLTFLAKYREFHTLYDSGDVHTATSLLLSLISSRLAPKSFWMTMLLDALPLLNLEKVALGVQQTYEMMHCLDELQRDGESNQKNFTDTALDKLKMLRMALTKNLSRAIIEEGSIKVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHU9</accession>
    <name>A0ABM0JHU9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101851631 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101851631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093992.2">
        <property type="nucleotide sequence ID" value="XM_005093935.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851631"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005093992.2"/>
        </source>
    </evidence>
    <sequence length="842" mass="96418" checksum="76B8B2C7777DE18F" modified="2025-10-08" version="1">MCSQDHNDYPHLMTQRFLRDYIRLCETEEEQNSLCTFSQDSAEQKLVESCQFLLEKLKCNGDQREDQERLLEFFVSLGKNAKLDLDCLQSKETSEPTIFPEIKGITGKTLKTCPASQSGNNITKYESKAQAVLEKIQAQRKDPLKKFRETASVCEKKLLELENRRSEIESLYEEFKDCKSKLQVLETSKRQLQMPLEKFENFTEVPTGSVSHHKREEILKTYMAMEKNEQELKENILEGVLYSSTERLREFVAFFKEVEDCLESSIKNLRQAFAFSRCTSLLFEDDDKKSLMCNLSEKLHKTFCIAENVVKVADTLVSQVSSSEDQVSQLNDSRMELTELWCQLIKEAWVFESEPDLQLQCKGGCFAAKSRFTLILRLLGHHVPIRKQGIRAGVILENDCSSSLEIQSLCKMKEATFFHEEDGFDTVIKWIDVDLSEYSRTAKRSKEDKYYLFFHRICVQLNCSVVEEKVALSCFSLPFTVRTGSPQVWSYTGSVVWYTWAKEDMHQIPFSCPKTLDHFMVLALLEAKCKAKFPAWELQASEAYSLGKMIQLVSTPENQVSLHKFTVDDMPHSREHNKSHKWPFYAWFSAALNTAKAFEKFVFGDKALESQKVKKLYYFLDKEGLVHLARRHQLPKATAILKISQNRVDSPTGETPMAGVNVHIWTGKEIFTCRIELEASKENKYQLWRKIMQMKIRTGNGDSLPEYLLCTDSQMLKLEQPPPVKDEKNPDGYGGQQSQQPGYTVLESSFKKLNVKEEDEGLATSTSAITSPTQTPDVTEPSASKRPTDMPPELRDIVPFDSSDAAVDSAEYYGEMFSPLGISEYEIGADGESEGWREDGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI25</accession>
    <name>A0ABM0JI25_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MORN repeat-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094118.1">
        <property type="nucleotide sequence ID" value="XM_005094061.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860315"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052849">
        <property type="entry name" value="MORN_repeat_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094118.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16234" checksum="4DA00CF6E2A5177C" modified="2025-10-08" version="1">MPGEKKDKKKEKGPAEITSCVYMFPNGDKYEGDCIQTDAGSIERTGQGIHTSVTGIVYQGSWENDRMNGQGKLTNPSNASYEGDFVNNQFHGKGKYCWPNGSFYEGQFVENRMEGEGEFTDTEGQVWTGTFRYKAAPGLKFKLAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JID6</accession>
    <name>A0ABM0JID6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101848735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_005094337.2">
        <property type="nucleotide sequence ID" value="XM_005094280.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848735"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="8">
        <location>
            <begin position="75"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005094337.2"/>
        </source>
    </evidence>
    <sequence length="277" mass="32579" checksum="DA172275F56B5840" modified="2025-10-08" version="1">MLHCPPHENPNSWVLKTDEAPSRFTWLQSLNRTGLKEQFNWTITHKLNSDIVQRYGYLVARDSVPVKDYDKIYNGKSKTVVWFVSHCPVRSRRKGYVQKMKVRTDVDIFGMCGDLSCGTAPKGPGIVGLREKADVETCFPMLSEKYKFYLAFENSLCQEYVTEKFFKLFNDVDVIPVVRGGADYKSYFPPKTFVDASDFSTPEALADFLEDLGRDRERYIQYLKNKDRWRSVRDFPQWQCKLCEKLHTDRNRKRYANVHSWWVYKSCHDDVIDSLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIK8</accession>
    <name>A0ABM0JIK8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094467.1">
        <property type="nucleotide sequence ID" value="XM_005094410.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858013"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005094467.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9021" checksum="A1A085F6D0D7802A" modified="2025-10-08" version="1">MTDTTTKKPDLGLLEEDDEFEEFPAEDWNGEEEEPEDINVWEDNWDDDNIDDDFSKQLRAELEKQGKNPDGTEPMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJJ5</accession>
    <name>A0ABM0JJJ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UPF0472 protein C16orf72 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101851113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005095137.1">
        <property type="nucleotide sequence ID" value="XM_005095080.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851113"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040308">
        <property type="entry name" value="HAPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31624:SF4">
        <property type="entry name" value="CHROMOSOME 16 OPEN READING FRAME 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31624">
        <property type="entry name" value="UPF0472 PROTEIN C16ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005095137.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29195" checksum="1AC31187BB9FAF79" modified="2025-10-08" version="1">MSQEDNYDNEQSPDHWSSRFEDECFGELEAQGGVESRVQSIEEHTAQQLWLGFQQTSTAIAQLYNFKDSAHDGYVLLVPFNKAAESLTKFYKDSLNNARECLRLGVQSGRSSRARDIAAWARKKRKSIRRDELLAYLCGKSLPPHHRNRQNRSLERQIPRFSSHQAENLESGDYPVREPFSLQGLNGAMSNISMGLSRASTTPTTTTSSTMSSWPTDEFRFHDDRARGEHHRKRTSSSSAMDVSMESPSRKRGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLN0</accession>
    <name>A0ABM0JLN0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centromere protein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101853309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer with CENPX, sometimes called MHF; this interaction stabilizes both partners. MHF heterodimers can assemble to form tetrameric structures. MHF also coassemble with CENPT-CENPW heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex. Forms a discrete complex with FANCM and CENPX, called FANCM-MHF; this interaction, probably mediated by direct binding between CENPS and FANCM, leads to synergistic activation of double-stranded DNA binding and strongly stimulates FANCM-mediated DNA remodeling. Recruited by FANCM to the Fanconi anemia (FA) core complex, which consists of CENPS, CENPX, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FAAP24 and FAAP100. The FA core complex associates with Bloom syndrome (BLM) complex, which consists of at least BLM, DNA topoisomerase 3-alpha (TOP3A), RMI1/BLAP75, RPA1/RPA70 and RPA2/RPA32. The super complex between FA and BLM is called BRAFT.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096596.2">
        <property type="nucleotide sequence ID" value="XM_005096539.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853309"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005096596.2"/>
        </source>
    </evidence>
    <sequence length="79" mass="8968" checksum="EA1D8A4351D98D1C" modified="2025-10-08" version="1">MSQQSASFKPKTVSSVLKLHLKNEKVTVKKRPLCLVTELMRIFSKEALTRAADQAKNEGDSQVTLEHFEKILPQLLLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPB3</accession>
    <name>A0ABM0JPB3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101851188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005098370.2">
        <property type="nucleotide sequence ID" value="XM_005098313.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851188"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044994496" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="37"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005098370.2"/>
        </source>
    </evidence>
    <sequence length="604" mass="66873" checksum="DFCF85EA2B342766" modified="2025-10-08" version="1">MFPSLGRSSLKSSVLAVLCALAVLCMLTGHSLAQGQPHVIVNGSDVYGVVRQWEGQSYHAFLGIRYGQPPLGKLRFARSDLNPLPPVVNASRRGARCHPVIPDQHADEDCLFLNVFTPANRTARDSRAVLFYIHGGGNILGNADGGDAIPLVLGGDVIVVTVHYRLGPLGFLSTMTSDAPGNMGFWDQNLALTWLSRNIVSFGGDPRRVTVMGESAGGKATSLHTVSPHSRQLFARAVMDSGSIYGPSLYPWDPLEAGRRLATRMNCPTDRMDRMVECLRQRPAGQLSTEAYVMWPDMDTRLVLDLGWGAVVDDDFLPRNVDQRDTFHGEVIVSVNNNEGSLLAGWRLDLLESVIPGAWDRLSQCDQYSRHMVNQSLFQYFRSVPPESAIEATTERYINCTDDGHIDIVGAMNLYADQQYLAPALRYLQNHIAQGPAYFYYFDHDVPEHWGDNPIFRGANHAEDRRYLMGWTGPMTLDPATAHREEALSGVMMTYLANFMKTGNPNTPSPVPVTFPPYDQEKNSTYLHMNSDLLDPTRAASLVDSEFLPGRMGLWLEELPALMAPERHDPNNNNGDKLRLGISMGLAGLVMALVSCLFAVRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPC2</accession>
    <name>A0ABM0JPC2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Proprotein convertase subtilisin/kexin type 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101856427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098392.1">
        <property type="nucleotide sequence ID" value="XM_005098335.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856427"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF28">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046490092" evidence="9">
        <location>
            <begin position="27"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="10">
        <location>
            <begin position="747"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="967"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1074"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1079"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005098392.1"/>
        </source>
    </evidence>
    <sequence length="1121" mass="123694" checksum="FEB2770C438E47F7" modified="2025-10-08" version="1">MTSIAKWSSVALFLFLFLLVLPVNWSFPLRDLESTKNRTRNLDQQQPLLCWVVQIRTSCAPQATKFWGDATNSGGEDEHVARDENDVKVCSACKYGDVCTKTWYQHASALATEMRLVVIHSFKHFPDHFLMCHSLSTEMLAACKTEEIPTFVENIENSPHSPSRSLHLIQQQHSRMRLKDAQSFHVTRSGVEQQLMEHEEVVWFSGESAHLRVSRPGGAVTVAPPTFHSANRGDDDLFVHNKDRFSLNEEPVVDGLSSVNNTTVLKFLTPNRFLRKMPQSTYAARKSKHKWKSFKDFETFEPESSEVVNDGSKFPPAINATSSAITSDPWRSERGDDSHNLPLRAHKKQEWKDRLVKEMRIVGRGKEIRIVGRGLETRNAGRGKEMMMSEALTDQKSGHERVKRSSGRPLSFNDPAYPQQWHLHNIRQPGMDINVTGVWDHGFTGRGVTVAVVDDGIEWRNPDLKQNYNYKASWDLNDDDPDPTPRSAKVSNHHGTRCAGEIAAVANNNVCAVGVAYESGISGVRVLDGVLTDSMEAQAFNTKMDINDIYSCSWGPDDDGRTVDGPHIMAAKAMKHGIDFGRNGYGSIFVVASGNGGVNKDNCNFDGYANSIYTVTIGAVDEEGGMPYYAEECASMLGVTFSSGTVSKRDIVTTDWTQVGGHGCTSRHTGTSAAAPLAAAMIALMLQARPCLSWRDVQYIMILTAYKIDVDIAHWQKNGAGLEHSHKHGFGLLSAWRLVNAARVWESVPWATSYAHTETPQRLDIPKGASNPLRISHVVSESDIRGLSMFTLENAQLTVWLSHPCRGKLGVKLISPSGTVSVLATPRPKDNSSAGFDDWTFTTVRCWGEKPTGTWTIVFIDHDNGKYGGGWLVKWRLILFGTPLTPEEFAERRRRIETAMSGDFLNANHSRPCPPAPHVAEKYSPVSQRTLKILILLGSFCLVIGVYETIEYLLCYNEEKKEHAKKMGLTQRALQSVDTSNSHRNGDAGGDRTPLVGGNAETSTDVEADWRMAVGDDDDGDDEIFNASETSQLLRAEPSSRGGSGGGGHHHRRVPEVIPLATFSLTSGEANHSELVVHPSPRSPLLLSSSDGVDAPGSGQAARPVMDVVATTNDLLSDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPD7</accession>
    <name>A0ABM0JPD7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101860654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098411.1">
        <property type="nucleotide sequence ID" value="XM_005098354.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860654"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005098411.1"/>
        </source>
    </evidence>
    <sequence length="936" mass="107754" checksum="69B861172C856EA3" modified="2025-10-08" version="1">MAKQVQPSLESFLQAGDTPQPRPDEVAKTFKRRSVNIDLQKSIQLLDDAVSPSVNRPVRTPRSGYRHVNYTPNRLDSRFNTSVKDVFVFTPAKTKEGDELRTQNISPVLPILTTTQNMEFTTGIDMTEDLTQSNLTFLADGDPGLKASSGLYEDFMSAMKRCPAPHQVMDLLSCYEMSCSELVTKLKKLQKGVTRNQPKLKRTVTTLGLLRGELETWQLVKSLYKDRLETEAKDDDMNSNDEGLLTKVWSLSEQNITSHLYEKDRLVRQSQLVIDWLEMCAAENLDTWAENVKMFVDQPVSWENSLHHLQKMKQGLRATTERPTISEMDPDAPHRQRKPLDDLDKEDERLLLKCLFWCLRAGQLDKAQELCHICGQPWRAASLEGWRLLHDPNYYSYSSAGDGKQSSVEGNAYRDVWKSVCWRMASETELDKYERALYAALSGNLESLLPVCVSWMDFLWAYYKVMVDIKVEQEIRLHRHVTRTLDSMPPEFWDKMLEPQEIFKEIGASVDEAVRQESEHWYHLIQKFVILGDVPALINVMHSWLQNRKDYLPQHLLRLMVHIVLFLKSIGHVSKEDLCEAIIEAYVADLIKSKRKSLVAHYVATLRAPAQVQWYASFLEGVEETEERQQCLVWAEEEGLDVAAITKAVVERVRDRETTALPPENSLAPDVTVTAEDRAKIDAIDWLVFDESHRSEAMKQANAIMRAFIAVKKHLAARQAFEKLPTDSIDVIYRQWHLQTGTGELPVEDSNAIREYMCMKAYLDAVESFNDWFSLYHQGRPAKPSVGSEGVASFTDRVALEHKMKQYQMEMERWRHSLRQQTRVTKDRIYNVLLFADGGWLVDAEEETDMDEVRQRQMSQLRKLHLPALCLNLHNVLHSSEMYADAVQIADVIASEHHQLYQDFDTESLQHLLGQISRSSRCLLDENKDPLGYEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ26</accession>
    <name>A0ABM0JQ26_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101848969</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098886.1">
        <property type="nucleotide sequence ID" value="XM_005098829.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848969"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047122164" evidence="3">
        <location>
            <begin position="29"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005098886.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21071" checksum="6F02EDE890B20F3E" modified="2025-10-08" version="1">MYHINSGIDRKLQLFLWNLLALLPLVLSAPTDDGNALGDSGTLQSLTSDNIALGVIVCVVVFLLLVVVAVPGCMDCMNSEVSSESHPACGDTSRKWGGAVDYTPADSRNPGAGFTTGEVVNPSDPYNQQLPYAMIPTQVPEQAGFVGYQSGVGGDGGLAGYSAGPGRHPSGSEQHQQQQHRHYNPMSPEDPPPAYTDAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ85</accession>
    <name>A0ABM0JQ85_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Uncharacterized protein LOC101854640</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12 13" type="primary">LOC101854640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098992.1">
        <property type="nucleotide sequence ID" value="XM_005098935.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098993.1">
        <property type="nucleotide sequence ID" value="XM_005098936.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005098994.1">
        <property type="nucleotide sequence ID" value="XM_005098937.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825824.1">
        <property type="nucleotide sequence ID" value="XM_035969931.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825825.1">
        <property type="nucleotide sequence ID" value="XM_035969932.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854640"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031964">
        <property type="entry name" value="CARD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16739">
        <property type="entry name" value="CARD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Caspase recruitment" evidence="7">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005098992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005098993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005098994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035825824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035825825.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45548" checksum="81D23298731D6CD3" modified="2025-10-08" version="1">MDRPDSGKYREELIKAIHKTFVEFVDPSHFMIFQRSSHDLLTKADKEEVEKLLQSKGETHAADLLLIKLSNHPGWFQCVLDVLRSDDMKRKHAADEMESQKRQLDLRLSKNQQVQEHISMVYAKQEVKSDFELGASKRQDQSDDSCSEISDRNLTEVKGRYSEGLLDTSNVSSAQGNHPSAIKGSYGLDTTEETELGACVRNLSMGRKTALRSQSQQSRKQNSSKRVVIQTEEVKARNHTRVTQVAPPKQRLAGVHGEEYDFNQREVKESLGNMDGWLDVLTDEEVYLFMDSKKEEDGHYLLWYWERKRRPAICVTCKMKLKVFTIHKKPMKNNKTQVDFYFIYKRQRREKTLEEIVKYHIQNGVQQDASTSGVSPIVKFSHPVVVAQTELMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQG7</accession>
    <name>A0ABM0JQG7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101851642</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_005099150.2">
        <property type="nucleotide sequence ID" value="XM_005099093.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851642"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="141"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="14">
        <location>
            <begin position="293"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="242"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005099150.2"/>
        </source>
    </evidence>
    <sequence length="458" mass="51807" checksum="0E2D96D65B64D1D3" modified="2025-10-08" version="1">MRRATGVALVMVTAVTIFMMYTFADRLPLPVGLLEWSGVGADSSNPWAPVAKARPEGRILPDEQIFYPALERPLGPRCLNSSADHTLMSSRIKPGLILFHKFPDYYGLDTRLGSEVFRSCSNGSSSSSSSSSNNNNNNNNNNNNNRIDATQCEITTDSRRFQEAEVVIFFSHQHINPAVKNVTGIVRTPGQIWVFFTVESPVYSNNDMFGGPFWRGAFNWTMSYRRDSDLWHGYGRVIKISESESESASPPSRGDSEHKGVAGESKRVGEENAQETKTDEKEDEIRILREQFRNKTKMAAWFVSNCYTQSRRQAYVSRLSRVLPVDIYGRCGTLKCADRTHCMSMLTQDYKFYLAFENSLCRDYVTEKLFKVFIQGGVVPVVRGGASYKTMFPPLSVIDAADFSSPEALGKYLLKLAEDEDEYIRHLSWRRHFRTEGSLFSFCELCQKIRSPDRGSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQI8</accession>
    <name>A0ABM0JQI8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance-associated protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101863270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099201.2">
        <property type="nucleotide sequence ID" value="XM_005099144.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863270"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18601">
        <property type="entry name" value="ABC_6TM_MRP4_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047083">
        <property type="entry name" value="ABCC4_TMD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="105"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="413"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="759"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1080"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1108"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1145"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005099201.2"/>
        </source>
    </evidence>
    <sequence length="1185" mass="130568" checksum="F7F0C4BA0F892A90" modified="2025-10-08" version="1">MKVLSGKAVWGALYNNSVFLVNLAFLVSYFLVEEQPRASIVYSFVAYSIILTRLWMGQVFLAVFTIADTYVAKVRVQNFLLLEELDHSSNVEKSNLRPKPEDAFVQLDGVTAKWEGEGTSEQNTLESISLSVKAGQLVAVIGPVGCGKSSLLMSILGELPTQKGDVRVSGRVAYVSQQPWIFSGSVRQNIVFGGVFDKSRYDKVVKVSALKRDFEIMPQGDATLIGDRGVSLSGGQRARVSLARALYMDADIYLLDDPLSAVDTAVGRHIFEKCIVGYLKHKPRILVTHQVQFLPVADNIFILKEGKIESQGSYDDLSQSGVDFAELLKQTEEEEGEEAVSPGLTSVPEEVAVPPMPDVQDLGSQMSLHSMVDDYEPEPVQLPEQEERASGTVGFGVYLEYFKAGTGVLKFTFLVLVNIAAQVFYVGSDWWLSRWSNLEEDRYAAIKAHEHFLADNNITDLANTSLSSNITIPYVDSTFNIGIFSAIIAVVFLFGLVRALLFFKIAVDASQTLHNQMFARILRSPISFFDNNPVGRILNRFSKDVGHMDDLLPVTFFDFIQCSLLILGIVLVAGVVNPYVFIPTVPLGIMFVIVRRYYLQTSRGIKRLEGTSRSPVFSYLSATLQGLHTVRSMKMEEKFMQEFDNYQDKHSEAWFLFLATSRWLAVRLDWLCAGFVIAVTFCSVFAAESMSPGLVGLSITYTMTLMGMFQWGVRQSAEVENQMISVERVLEYTRLPVEAALESAPDKKPPPTWPSSGAITGTDVNLRYSPDGPLVLKDFSFHINGMEKVGIVGRTGAGKSSLITTLFRMVEPTGAMVIDGINIQGIGLHDLRNTIAIIPQDPVLFTGSLRKNLDPFSHHKDDVLWKALDEVKLREQVKELPEGLGAEVSEGGINFSVGQRQLICLARAVLRHNKILMIDEATANVDPITDELIQATIRTKFRDCTVLTIAHRLHTIMDSDRVMVLDNGRIVEFEEPYTLLKEGQGYFYEMAQQTGKAEFDHLMEIAKEAAEKRANSPRVANGVKPGTLRPKDDPRSDSTLNDVPSSLNSNDLAATYDISDIETSLRTMDDDDDNASDATGDERRVKVAADDDKGQDASERSTAESERASLLPASGSASSSSAKTAGKGSAAVKDSAQKSRGKDDGVDEEEEEEEDDIDESDVLLRSGDRGQVSDSKGHGGGSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQM9</accession>
    <name>A0ABM0JQM9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101858272</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101858272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005099259.1">
        <property type="nucleotide sequence ID" value="XM_005099202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858272"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="54"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005099259.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39779" checksum="362F455A44DAD4D5" modified="2025-10-08" version="1">MDAALNNTTADVAGVEVPVQMKGLGLIDYSTTILLTNIFLYGIWIPIVFSGIVTNIINTVVFVRIGMKDSVNVSFLALSISDLLYLSFNMICLIPSTLTFSGRPTKWLQSPYTLNSYIVWYAILFYDLSILITTYVAITRCCCVTLALKFRSFFTVSRTYTVLGVLSVVCLAFHIPMIASQNLQWQTDKKANTTKLTLVRSDAFPDVQYFHDITNRNVVPYTCLAINITCLAALTLTLQSATQIRNKMAISASTDGNAGKRDSKLSTKDIQVVKAVSLVAAMFVYCSLLTTIKALVRRAIPDYDSRGQYRNLFQLTTGVVTIFTYLNATVNITVYYHFNTKYRQSLIEIFCKGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRQ0</accession>
    <name>A0ABM0JRQ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannan endo-1,4-beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100017.1">
        <property type="nucleotide sequence ID" value="XM_005099960.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857411"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37398">
        <property type="entry name" value="ENDO-BETA-1,4-MANNANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37398:SF3">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046529153" evidence="1">
        <location>
            <begin position="20"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005100017.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41455" checksum="0228BE62F62DCE15" modified="2025-10-08" version="1">MKIACVLLLVALMVHESSQRLTVSGKTFRLNNQQVFLSGGNLPWINYARDFGNHQWSKVKPKIEEQIRLLHQAGGNTMRLWVHIQAESSPKFSSSGFVTAPDNDGTLLNDIKDLLDTALKYDVLIIPCLWNGAVNQDNAHRLEGLVTNQQKLQSYIDKALKPMVAKVKGHKALGAWEIINEPEGLMIPGVKDNTKCYDTVATQNDGMGWAAHKYKYKDMLRFINWQAAAVKAVDPGALVTMGVWNPKSNTDHFGKVNHYSDACLRLAGGKHAGVLDFYQFHSYSWQNKWDNVSPFVNSASAYGLNKPIVVGEFWEKESAGMNMNELFSYAYNHGYAGAWSWDLMTYGPSQRAGMTHIKNLSNHGKVHIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSM6</accession>
    <name>A0ABM0JSM6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Calcium-independent phospholipase A2-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101846741</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100571.1">
        <property type="nucleotide sequence ID" value="XM_005100514.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005100572.1">
        <property type="nucleotide sequence ID" value="XM_005100515.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846741"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07211">
        <property type="entry name" value="Pat_PNPLA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045217">
        <property type="entry name" value="PNPLA8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="319"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="323"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="355"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="500"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005100571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005100572.1"/>
        </source>
    </evidence>
    <sequence length="647" mass="72175" checksum="3B998B4AB7CC69DC" modified="2025-10-08" version="1">MSVLKLQAGLRGIHPQCLASNAYPGHAKFASGKEEDTSQSHRHLGTFSSTFSRRFRAGDAHRTEKSSDDLNVQSPLGASPPAEEKKDRMKINFSSLGATVPLRIAEMNRYFADTSKKFLSSRNPLNRNGTSSNSTMEEKSVPTDQTSSLEHSLTQMNQSIISFYDTSCATNAPHQAENMIQRGVAMQESVDDDSVSADTPQTIGPLFPTVLPAEMKKKRAEARRAQKISRLSLESRTKALVQSLKSAHSLMSKITRAEELCEHLIAHPECVWDAASEKAVPCVKKLTASPDKLLKGLAHEILSLLGHVKPLSAPGIRVLSIDGGGTRGLVTIEFLKALEKQSGRKIHELFDYVCGVSTGALLAILICLYKLPLDRCEELYKDCSTQMFTRNRVLGTTKLVWSYGFYDSQSWEEILKREMGEKSLIEFARDPDVPKVSAISSLMNSQRMSSHLFRTYNTPPGASSQYPGSCRHKVWEVVRASSAAPGYFESFKLGDEVHEDGGILTNNPTALGIHESRLLWPKENFHCVVSLGTGRFDNSSISETPAKMSLKRKITTIVDSATDTEAVHQTLQDLLPARTYFRFNPYLSEEFMLDEIRPEKMAQMQLDAQMYTRRNSYKLTAVSDRLMEKRKPQQVAGDWMKRVLEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU48</accession>
    <name>A0ABM0JU48_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MRG/MORF4L-binding protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101857033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101547.1">
        <property type="nucleotide sequence ID" value="XM_005101490.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857033"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005101547.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23773" checksum="DD3081B7B89A2B06" modified="2025-10-08" version="1">MSDSTELIWNVDMEVNLFHAMRGHKPAGVNRHFQMISVHDRLISSHKKLSSKDVWTHLSTLYDLQALNESEIVPFPNKNGEFGLRESDLVDLCEKSFPRTSYINTPAETAKTETSQTKSSSKSGKQDSKSSSHSSKSDSKSDSKSSSSSSKHDSKSGSSSSRGEHKSSHSSSSKSSHHSSGSNTPGPSPKRTKRTRNTPSSNSSPATPTEPPQKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUA8</accession>
    <name>A0ABM0JUA8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminopimelate epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101656.1">
        <property type="nucleotide sequence ID" value="XM_005101599.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863593"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689:SF0">
        <property type="entry name" value="DIAMINOPIMELATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="DIAMINOPIMELATE EPIMERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101656.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="39632" checksum="EB1FD907E5CBCFA8" modified="2025-10-08" version="1">MEVHFSKFHGAGNDFIAIDNRDRSLNLTVKQRKDLCHRKFGLGADGVLELQTSETADFKLVYHKANGAVGTLCGNGSRCAMAFARYVGVRFGDEKRISFEAYDGVYYGAVKEGGSSAGSCGEYTLCLKDIPLSSVRKYANADYFMDNGSPHHVIFTDGDLENVDVFTIGSNLRYNVYDSIGGCNINFATTSKGEDKNSSLPLAQENDNKAASDLENLTLDALNRQEENKKSAKVLHKSLMSRTYERGVEGETLACGTGSVAVAIADFVRCAEKSPPSKLIYDAMRLLKETKTCDLDGSNLTEGKVITKVQMPGGLLTVTFDVEVQNMPENGRRPVVLTNVQLSGPAQHVFDGVCRLSTIARNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVH5</accession>
    <name>A0ABM0JVH5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Trimeric intracellular cation channel type 1B.2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101859342</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM38 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102510.1">
        <property type="nucleotide sequence ID" value="XM_005102453.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859342"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007866">
        <property type="entry name" value="TRIC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454:SF11">
        <property type="entry name" value="GH25683P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454">
        <property type="entry name" value="TRIMERIC INTRACELLULAR CATION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05197">
        <property type="entry name" value="TRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005102510.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30371" checksum="83DA559E0FC7A04E" modified="2025-10-08" version="1">MAAEVSQFAKWVMEVDMFPVFFGAHFLLASTIVREDSKDLGPRFRQEHPFAMWFCTIMAGLSGVFVANFLFGDPLVDVMKENALIIYLTLVWYLMNYSPYDAVYKIALSPPVFLSASVLQECLRVRFIFLGLKQAARVYPGAYIIILLGGVIKGNGYGFIRVVERLIRGKWNPGNNDILEVTYFAKSGLYASFLFLLHHFKFLNVPIEFLYLGVVAVFIICRMLTAVAGIKDPFLPIELPICRVLFGSTGKEKVAAKDPVKDKLDKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWQ0</accession>
    <name>A0ABM0JWQ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuropeptides capa receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101850264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005103326.1">
        <property type="nucleotide sequence ID" value="XM_005103269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850264"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005103326.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25020" checksum="A08AE078BBC79DFD" modified="2025-10-08" version="1">MIYGLALNSSCTAVFITLERCLCTVLPLKVKDIITPRRSAFVLGAIFALSMASISPILSVIHLLWKYDPLTNTTVPNTHFASERPMNLIVTNLLVANLQATSFVFLLAATGTLIVTLRSKSKWRQQVSASNQAETLSCRDHRVVKMVVIVSSVLLVCYAPAQSIPLTSMVVPEFHYRRRYSNLYGASWALAYFLYAVNSSVNLVIYYNMSSKYRRTLNELLGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXA4</accession>
    <name>A0ABM0JXA4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101863118</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101863118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aerolysin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103722.1">
        <property type="nucleotide sequence ID" value="XM_005103665.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863118"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.412.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055267">
        <property type="entry name" value="Aerolysin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01117">
        <property type="entry name" value="Aerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045978347" evidence="3">
        <location>
            <begin position="24"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Aerolysin-like C-terminal" evidence="4">
        <location>
            <begin position="183"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005103722.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="56509" checksum="7FD5CFBA9FA8B79B" modified="2025-10-08" version="1">MTEYRVLSVAVLCLWFLSMVCLACNRNSDRKYETRFCKSRKEVIKGFPTLISEHSLKNPSCVTAFSSRLNTHTLVDNWWTLLDSKQTWVFCPAGYFLQGFKFTKNENGIHALEEGRCTKEVSAPSSYERCYRQDTTTSTMCDKDYFLAGLQRDSCRGWSCVRMLKCCSMPSSREFIIDSLEVAKDKIMLQSLKGLAEIASFLGYDGAKGCFGQEVGDNFVKNGTAWEAKKCEHRDNPQLKISYKDWKFTVLSHSYSKPKTVDLPPEEIDRGDFINDSPLPIMETVRNTFNISRTVKHTLKSPWKGPDGIGVEVSYYPVFNTGDLGKEFVFDITSDQGKAKTIKITSTRRQSERHRELGPYTESRWTADLYRKQTTQNYQATILIHCSVQLEGRLKTEIAQLTEYTDDLKRYTEKSGNDAVYQFGDEGKPFFVALSDEQELWDKSTLDSQVMDILVERLVDRKRYEFVLEGKFEDTHGDFIDIGFAENNMTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXD2</accession>
    <name>A0ABM0JXD2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">BCS1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101853636</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103770.1">
        <property type="nucleotide sequence ID" value="XM_005103713.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853636"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="217"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005103770.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46921" checksum="0D82765CE04B591F" modified="2025-10-08" version="1">MPFSDYISTLGDNPYFGAGAGLFGVGVLAAVARRGLQGATIVFRRQFMVTMEVTSRDKSYQWLLQWISKYGTKTQHLSVETEFQQTAAGQVKTRFHFVPSPGNHYFWYKNYPIFVERNRDNKMVEVFETVTLTSLGRNRELFMNILEEARTLALLSTEGQTVMYSAVGPEWRPMGYPRRKRPLNSVVLDCGISEKIRDDIQEFINNPKWYMDRGIPYRRGYLLYGPPGCGKSSYIMALAGAIDYSICVLNLSDKAMSDDRLSYLLTNAPEQSIILLEDVDAAFVSRDLSSENPVAYQGMGRLTLSGLLNALDGVASTEARILFMTTNYIDRLDKALIRPGRVDVKELIDYTSHFQQEQMFRRFYPEEPESKAGEFADRIAALKCPVSAAQVQGFFMLHKSDPDSVLVHAESIADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYB9</accession>
    <name>A0ABM0JYB9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase 32A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104436.1">
        <property type="nucleotide sequence ID" value="XM_005104379.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850827"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104436.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31245" checksum="A68B49DD5F403DD9" modified="2025-10-08" version="1">MSSEQLMEFTCLIKMEKENDVFNYYHIHHVSILHQGQRSKVLMGVSNITPDKKFAIKLMPLHHAKDTNRFAHELRMMNHLADIPGVVPLLTPFISGHTGYLVMPYYGKGDLLSQIGNFNDYSWFKVLVNTAVSLQSLHKKRIYHQAMMPENILLTRSNNPYISDFGAARKLSEGCDKVDTWTAPSGFRGPEADREEGGEFCPFQMDTYSLAVSMWQALSGLCPAIYHPLDHLEYIPPQYAHFLMYLLLPDPDKRWTLAKFLNEVLVLHPELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYJ0</accession>
    <name>A0ABM0JYJ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">NudC domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6" type="primary">LOC101854593</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104541.1">
        <property type="nucleotide sequence ID" value="XM_005104484.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104542.1">
        <property type="nucleotide sequence ID" value="XM_005104485.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104543.1">
        <property type="nucleotide sequence ID" value="XM_005104486.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104544.1">
        <property type="nucleotide sequence ID" value="XM_005104487.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854593"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.740">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF18">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005104542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005104543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005104544.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17477" checksum="5173A2671B42CE0C" modified="2025-10-08" version="1">MTHFDERSGVIPCKTEWGFWWQTMEEVFIEVASNQILNAKEVKCNIKPRAISLSIQGATVFQGDLYEPVHADDAVWTLEDKKMVRICLSKVHSTAAHCWPSLLKDQYRADPVTFDEMQKKLTLQRFQFENPGMDFSNAAMTGNYQNGGPEMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZN9</accession>
    <name>A0ABM0JZN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">5-hydroxytryptamine receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101852112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005105306.1">
        <property type="nucleotide sequence ID" value="XM_005105249.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852112"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15065">
        <property type="entry name" value="7tmA_Ap5-HTB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF163">
        <property type="entry name" value="HISTAMINE H2 RECEPTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="53"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005105306.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50622" checksum="EC2BFF52D44D2895" modified="2025-10-08" version="1">METSEKSAHGLPHTENVVWAPPAYDEQHHLFFSHGTVLIGIVGSLIITVAVVGNILVCLAIFTEPILSHSKSNFFIVSLAVADLLLALLVMTFALVNDLYGYWLFGETVCFIWMSADVMCETASIFSICVISYDRLKQVQKPLLYEEFMTATRALSIIASLWICSFVVSFVPIFLEWHELSVEEIKAIFKGRNPYKDTVKENVTNVHKPNFSSVLKQTLRTEQKVTTKPECLFDVHFTYSVVYSFICFYIPCTLMLTNYLRLFLIARKHRHRIKSLEKTSLPQPGDEGPRSHRKRSSQGSKAARTLTIITGTFMACWLPFFIINPIAAVDEHLIPLECFMVTIWLGYFNSCINPIIYGTSNSKFRAAFKRLLRCRSVRENVGNVTRNSSVYRAFSWIRPSLIEEGLTQGQCCSSSRRAFDKGQDQTSVGVDYVIDDFPAPQAIIAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K047</accession>
    <name>A0ABM0K047_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein zeste</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105621.2">
        <property type="nucleotide sequence ID" value="XM_005105564.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863924"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="274"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105621.2"/>
        </source>
    </evidence>
    <sequence length="454" mass="49928" checksum="750CA088D79E1D5F" modified="2025-10-08" version="1">MSRRKQSNPKPIKHDEEEDMDSGGRSRDPDVAMMTVGDQEDSNVVTNGSAFHSLSKPNMTPGNEDPTEEIAHSNKVYVKVECAEEGDERSFGHWQDERAILSNNVEETADSVNGEDRNDNSPSDPTMSAFDDPASDKADREERETSQRHIEEETNGIDGTEIEVKTEPNASPSSPLAHHSNNKLPDINASSSSSSPSSSNYTPKHKRGQRSRSRSRSKSGGAANSPESRPPTTSRQSREKAEQALVNQLQLPSDVLYLKQQEMIVHGNRSIGWVVCCAIPLPQGSSLGPFQGQLVSSEAVKVGDLIVQFTNKKGHQALMNVAGQSGGWLALLRSTVSPSERNTHVYWEGGRIWCEIIADIDIGTELRASFSFQNDDDVDDEDESNETMEDVESAANDVKENGEPSSGEEGRNVSGTQQQQHQQQHQQQQQQQQQQHQQQQHQATPGHGMGKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1I1</accession>
    <name>A0ABM0K1I1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101863533</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106561.2">
        <property type="nucleotide sequence ID" value="XM_005106504.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863533"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005106561.2"/>
        </source>
    </evidence>
    <sequence length="116" mass="13357" checksum="EA34C0CFCE2DA8DC" modified="2025-10-08" version="1">MATRMATLNRLNVALRTCRRFYSAQAGEHGHESAKRWKSAFFFLGAPAVALVYYNSYYIMPQHPERDEFVAYPHLRIRAKPFPWSDGNHSLFHNGYYNALPEGYEEGSEALHGGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K240</accession>
    <name>A0ABM0K240_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101850031</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106943.1">
        <property type="nucleotide sequence ID" value="XM_005106886.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850031"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106943.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17019" checksum="8ECDE095C20E6FCE" modified="2025-10-08" version="1">MEYSNCKCVVSPHMTSHKSRPDRTGRELLVGFLGSLVGLGLSVPTFFLFRSWLRRCRSPGGFRCSRRVSKGNKPVGERTRRWVDGHNMPAVETPYLRKMPPSGLSGGSDVRSVASGKTNVTNIYRATFNDDNIHSTAPKKNLTTYRSGAKDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2A9</accession>
    <name>A0ABM0K2A9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ homolog dnj-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101857275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005107060.2">
        <property type="nucleotide sequence ID" value="XM_005107003.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857275"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032843">
        <property type="entry name" value="Jiv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052317">
        <property type="entry name" value="Viral_replicn-host_int_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44665">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44665:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14901">
        <property type="entry name" value="Jiv90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="738"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="821"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005107060.2"/>
        </source>
    </evidence>
    <sequence length="1079" mass="118175" checksum="F0CAE77236C1807A" modified="2025-10-08" version="1">MDDGEDPLGKISRQLSELAAAPSSPVSVGVQPLLGADDGSQWTQFSGISPQHNAGVRSLYTWNPMTLPDYQSMSPPPPVSHHDGTGVHVPPPSLSPQSPRLGGMNEFIQQHRQFEWKGEEVTPRYQVSGDLSGRFVDVDQSRMAAMNSDVQRQAYLGQGFHAPDPSVFRGDDFMGSPGMSGGGSPTPRSFASAMSHPLERSLSDVQPRASNFGHTFSAQLSAESYLPEETSMASNRGMHQSPLPHDSSVPHVLPSRLRFDPRMPPPPLFPVQSSVSESSVMEPHRLSSQPPNGREYSHLQGTSGINIDLGTNIEPGSRHYANNTSKHVASDEGREIYEAAMSQWNSSGHGHQRDSSSPASPVGTKPESQSAETTKPSYSDIAKTPKTGASASVKTTGLGFYDLENKLSESGSKPQGKKPPAKKEGKPFRPHIKRTSSGSKYWPRGSLGGDADQHRTSPTSRYGLDSFDDHVLSPGSSSENLSPAGKIRRSSGSSAGSSAGVLEDISLGTTLSSVTREDGEHQTLPSPTAAKCSDTKNSTSQPASSGESLFFDPRRIFQTKNTNKSRAQSQQGQQAASKNKGHAANVLEDTSSAASSSQGDMVLNNGKPTASNSSSKLSSSARQHDYINNDLRDTSKLTNQAAAAESSQQTHSKSHREPRSGTGKRSSGRSNNGVCRRDRRKSPDMPRNSHSEEVPNERNRFSFLSDHMDMEKIEEWCSVAWDQLKVWGNLLFAATMSLFIYLLGVVLYLASGAVQLMVVLVSRGWQLVRERLLRGWLGSDGGQGWSGRDVPRRRVGLEENINLPATGEEAMKRLLACKGKDPYSILGLRADSTDEDIKRYYRKQAVLVHPDKNQEPGAEEAFKVLGHAFEMIGEPSKRKQYDSHTQEANEAEAMREFADMLSKLQTKLQEAANIMHCDNCGGKHRRVPVDRPFYSARFCQRCNVHHSAKEGDVWAESKMLGFYWHYYALMEGHVFDITEWMKCHKEFFQHMKANTHGVSYRIATDGNRKNRHHHQPGHGEAKWEDIINRLFSKASNGGGDGTSWTPPHVNADMGWGAQAGASAAATTANAKKSRRRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K2V2</accession>
    <name>A0ABM0K2V2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_005107477.1">
        <property type="nucleotide sequence ID" value="XM_005107420.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858666"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="2">
        <location>
            <begin position="172"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005107477.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36663" checksum="02EDF4E712B3171E" modified="2025-10-08" version="1">MSRKLMIFQRCFLVPHHRTAWASWAWDRCLSHSPVLKPFLNGTVQAKNTSASGINRQISSYSGINIAATQKQTVPEPRKAHTHHRYLLPYSASDRTYSPFQNLLFRLSSSTSGTAADREKSCDYLDATDSAIYDILAEHMTVVKDFLSEDEEKSLLDEVDSYMKRLRYEYDHWDNAIHGYRETEKRSWNDANSQILQRVKDIAFDGGVSPLAYVHVLDIAKEGYIKPHVDAVRFCGDTIAGMCLLSSCVMRLALEKDKTKFGDIHLPQRCLYIMRGKARYDFTHEVLKEEESIFKGQTIPRDRRMSVICRNEPDPADQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K399</accession>
    <name>A0ABM0K399_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="5">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101862373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005107758.2">
        <property type="nucleotide sequence ID" value="XM_005107701.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862373"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20912">
        <property type="entry name" value="RPC3_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="7">
        <location>
            <begin position="104"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="8">
        <location>
            <begin position="261"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005107758.2"/>
        </source>
    </evidence>
    <sequence length="451" mass="50616" checksum="903C26E0725C91FD" modified="2025-10-08" version="1">MLYGDAAELLVEELLLQGQSHLDTAVMKTTKKLNDSIVSSGASLPEISHNVIKEKVVTLVKARLIRRCEGVKKDENEKVVSLESHTDPNALFALPTAEDFRPATGSKRPQDAGPQGPAKRIKLESGAAVGTSDQEVPGTSSGPGYWCVNFHQFHHHFRDQAIIAAVSRNIDQRASEVMRTMLRLSETRTDPTFSESVHLSFTEISSAMPKDKAMNQQSLDQYLKCLSENCHNFVTRVGDSGGGMFQINYYKAIRALSVSLIESIVLERFGSKALRMFKVILAKRHVEQKQVEEHAMLPPKEAKELLYKMFAENYVSLTELSKTPDHAPARTFYLFNVNLIQVSRMILEKCYKAVANVMIRRDKCISENKRLLDKQERVEAIIASLDAEGAVEQKEEVEQMVTPSERAQLKKVGDASKTLEQSEIHLDHTIFLLETFLNYTLKPPPQKVPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3B4</accession>
    <name>A0ABM0K3B4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101849492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005107788.3">
        <property type="nucleotide sequence ID" value="XM_005107731.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849492"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005107788.3"/>
        </source>
    </evidence>
    <sequence length="392" mass="42759" checksum="CA27CB9AAE08293A" modified="2025-10-08" version="1">MTATLPEDKEKVAMGDEKVSTQGVSFPCMHSMWGRWAPAMERTRLASFTYAGTTVGNVITYIVSGLLCVYGFDNGWASIFYLTGGTAFIWLFVWFGFVSDSPEDHPSISQTERDYIVSHRGDRMSKKFKVPWKSVVRSRAMWVCLVAHVCKNWIHYTLLTGLPTFMKQVLKYDIKQNGVLSSVPYLAMIVTVLLSGHLADCLRHRYLSTTHTRRLFQSLSFLGSGACIVAVGFIDCERRSLAVVVLTLAVALEGLSYAGYMVNQVDFAPRYAGVLYGITNFISTIPGILAPIVTGKLTPNNDQSEWCNVFYVCGAFTVVGTVVFGGFASGEIEPWAAGDGGEGGEGDVNDMEVTVKPDTADVTLDNTGGGGGHCNKTFSKLDQKSEENVCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3X4</accession>
    <name>A0ABM0K3X4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101863056 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108176.1">
        <property type="nucleotide sequence ID" value="XM_005108119.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863056"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04389">
        <property type="entry name" value="RhoGAP_KIAA1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MyTH4" evidence="3">
        <location>
            <begin position="891"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005108176.1"/>
        </source>
    </evidence>
    <sequence length="1252" mass="137382" checksum="040D9BFD18592C79" modified="2025-10-08" version="1">MEYLNMAVSALATTAHALVASADASLYLLVSSASLMVSFILVFRKRRDHASRGGSGGVPSLRGAPPSGPMPASGGQSASSSVSSTPSKTPTGVAVQTSQGAQTSPKGSRKHRYQRQDSASSHSSAARLDDVGGVNGELRRRSSQTSTQSEQLPFAVINRNVMRRDSFEMPQRTIIDSPRPSRSRSLHKSPSDGNAPPKQAVSGVLRGDGKWHRGPLPHSTQPPQVTGGGQENYAFHRQASFDAGHPRQMTHVPSDPLFQSHHPYASLHHHHHQRQASLQEGMVARPGHGMSESQHSAYTSDLGYDLRAHQQQFPDSRQPASFHDMRGAATSASNVGPDPSTSLYQAYPGDMRKGSLTDFRHAAAPVYAESPYRKGSVSDDSSSHYSGDSGPMSMMYIRTDNAGGTDTPLGHERLYSPELRGREEYLAFSQDIVGQQGHVSPAPHQGAGGKSKRSFPRTNPNYTGLSRRSEGQSPGSSGIYKKIGSLDSQHSGGSSSGGYDTAGYILAGNGGIAQSMSVQTSQSFSDTYSDSQSPLMPHHGGGGAPAHHTQYHHARSDSDTSHSSSSRAHPAYQESHLVQQQQQHQQRMDAAQGRPRGDLSDSQSSQGSSRNVLDMRSSQGSLKNLQDAASTGRASPRGPSRTDQSKGAPYLEHSGSHMPQRSNTLTADDQEPDYANLPPVNGHSTTSTSSSSNSGNNNTHSSGHILPPEVKGHMYPSEPPRFTTFGDEDDDDDDDDDDDDDDDDEDFNKENVHMRKDSYPDYDSVPELESDTSSIFSATPRSQVQSQPISIPAGMETQHASLRRKKGDKSDSSPAERSQSLQADVTVTPRPLSMVVPSQSDANMAMSPSTGSLSRGKLASDGDMEHYSQHLNRHKKGLFGKKVSLNNMLTWSKDPIQKPMIRTADKSIKKEACDMFKMIQLYMGDRKGKQAPMSVALDIITKGWSTPNLRDEIYIQLMRQTTENKREESLQHGWELMAMCLHFFPPTHKFHSYLEGYITKHKDINSDFGNVPVSHFSSHCSQRLERALQTGAKKGVRKPTLEEVEQAKKAIFHPSMFGSMLEDVMLLQKDRFPERQLPWIQIVLSEEVLRLNGTQTEGIFRVPGDIDEVNALKLRCDQWILPSDCPDPHIPASLLKLWYRELYEPLIPAQFYEQCVENYANADAAISIVNQLPDINRLVLCYLIRFLQVFAAPENAAVTKMDVNNLAMVMAPNCLRCESDDPRVIFENTRKEMGFIRTLIQSLDTSFMEGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4R1</accession>
    <name>A0ABM0K4R1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC101848075</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101848075</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108713.2">
        <property type="nucleotide sequence ID" value="XM_005108656.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848075"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0420">Kringle</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045310119" evidence="8">
        <location>
            <begin position="27"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="82"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="10">
        <location>
            <begin position="662"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="11">
        <location>
            <begin position="787"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="891"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="976"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005108713.2"/>
        </source>
    </evidence>
    <sequence length="1363" mass="155197" checksum="D2C9521B0DCE6EC5" modified="2025-10-08" version="1">MSDGATVFLRSALLCCLWACLVYAHAEEWRWESRSVRDGNNTTNFDPGRDSPKPEVREVTLSRPGSGLKISKVETLPRRQKRTVYTGPDVVWPFDIPYVYDRTAGLDELDIQRAMNLIEDRLCVKFHDETDRYNPHDPHWFTRYGNYKKDVYMKLEKGDGCNAPIGIGGTEPNYRSVKACHGWALNLHELFHAVGAGHTQNFPRAREYMTVNPDNILPDYLVWYTKNKPEPNKMTTFFDPTSVMMYGDNSFTINGLETTFPLRDDFFDLVGPDSGDHVVFMELAKTYKCNERYCGNNKTDCGRGYFTIIKGVCRCVCPDELDPDTNCTTHINASNKYVDWPKTPFTLLTGSQCPAGFHEGNIRLRGLGGHIQAEVADPFPLDDPYLTLRTCSKMTPDDHADIHWLSWPVGGQYCFIKPKDIPCDGVFKKGYFVLNGVYQVSGNVGDVSNRSSDVTINFCCTKKDRVDRSIDLPNDAPFKLLSAKQCPVVNGMRGTHENDGLVIYFTNRRPVVRGEAPLHYLWDQEIHFFQCDYLPPVYGCNKIIKLDGINRAETVKTPRSSSGRDPNRRCFYSFQVPKNARIRVTFHEVDMHEKDLLYVKRFHEWQAPHLLKPDDWQKQLISAGDYMTFEYWSWWKSAANEGVHFTADVLLEEELCYDPKTKGDDYTGDKSVSETYEPCLPWKDAVSCVDFPFDGAEGLRLLNSENKCRNPNSEMAQPWCYVYVNGTECKRRYCDVCNEREPFDVLQNCYDLIIADSTFCTTAEGRYGCSLTCDFSIHYYRPTGGNCTDKHELCDYWASQGECESNPSYMHWMCEKSCISACAKCQPPHIPADGSAVDMLKSEYKIGERVRIKCNRYHSNGPVIVTLECGLEGFPDVHSACAECPPNFRTYGDRCYSMSSDTLNRQDAEAKCRAVHESGTLFEIRDSTDQQMVMNLKSEENVWVSGEIQTDCTWKFTNSTTPITYSNWNDEYPGTCGDIDRSCGYWSERGECSKNPVFMFYHCQRSCKACCNGMCTDSSPYCSTWAKNGECDRNPSYMHHNCRKSCGLPNCAKDQCLLVHGSDAEEHKGPSGSWDTWLCTDPEFRVRYLCQIDKQRVDCHDSSGHCETALSEFPNFCNDARSSRGADVYCHRSCGRCVHFVHCTAPSSPVYELKSASRTAQPGDIMEFACADRFPYHIGGDLVRACASTGRLLGEAPVCHSSPVAMDVMKNRVRKRKYALYGNTAVLMDSPDYRVPLDGHITRWYYYCERPGLIYFFVTRGDRRTRTRRMVGYNAVNCTASWTMSYDVPAAEQLTVQKGDLVGLFVTEPYLIMISWCVHAQHKILQLPHTVATDIDSLNRTLSFKYSDPYCIVPSIAYRVDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K639</accession>
    <name>A0ABM0K639_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fatty acid 2-hydroxylase</fullName>
            <ecNumber evidence="14">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101859672</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_005109613.2">
        <property type="nucleotide sequence ID" value="XM_005109556.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859672"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005109613.2"/>
        </source>
    </evidence>
    <sequence length="352" mass="40893" checksum="8C7F059B46C9ECCF" modified="2025-10-08" version="1">MGFVEGDSGRNGLRKRLCLIRDGKVYDVTEFAERHPGGRELLVKHAGKDVTSIMSSADSHVHSKAAYSILEKYYVGPEEALREENGNYKSASENYSRPLDYYKNDIVDWDKPMLGQVELLGDKYFDWTHQQVDRPIRLFKSDLVEMMTKSPWWLVPVTWVPVVLYSLWSSYTHLSEKSEVWPRNALGREFGPVSIPLLFAAGVLFWTLLEYVIHRWLFHLHPPANWPFLIRLHFSLHGQHHKSPMDPMRLVFPPLPASIFAVLFYLACHASLPHGMANSVFAGIVVGYMAYDLTHYYIHHGQPMFPYFQRLKRYHTLHHYEHQQLGFGISSKMWDYPFGTLIPEDQSQVKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6H9</accession>
    <name>A0ABM0K6H9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA pseudouridylate synthase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101864099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109891.1">
        <property type="nucleotide sequence ID" value="XM_005109834.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864099"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045350874" evidence="3">
        <location>
            <begin position="23"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="257"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005109891.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="70880" checksum="946B14F059A45910" modified="2025-10-08" version="1">MWRRKLLSQRTALLRLLFPSSGSKVRVVLVSRGTADHFNLYGTNNFSFSNKFCVSATMTDITLKGESVPDVENNNSEPELVSSTAAMASTNSSETSLPSAAKPGPDGTPVEQPLSRRAQKKRLRAQQHRQLKMKRKAKNLQVAQKEDAGYNIEDFEQSEYYFENGLRKVYPYQYVFATYAKGRWVKRQLQEVLAKEFGYDHPDELKQAFEGGRIHVNNQRVSVDHVVQDCDYISHRTHRHENPVTAARIEVIEDTENLLVVNKPSSIPCHPCGRYRFNSIVFILGKELGYTNLRNIYRLDRLTSGVLMLGKTPEYTKVLEDQVANRVVEKEYVCRVVGKFPDDPVTVEQPLQALSNKLRLQIVSPTGKASTTHFKRLSYNGTSSVVKCFPKTGRTHQIRVHLQYLGHPIINDYFYNSEAWGPNKGKDADYGVAHDQVCERILSEHYANLWDGGDNPLYKEKFGDLEENKDETADSAEPLSTDCSCIGEEKTANPDSDEPLPKRPRLTDVEVSCPVESDTGLNTAEAGVLKSSTDQQTVEGVNGLTPSNEHPVTSACCRKDSGLPEFDVSKVSLEFGCNLCKRKGRDPTEKHLVMFLHALKYKGPGWQYETTLPDWAQPDWNKESDFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7I8</accession>
    <name>A0ABM0K7I8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pneumococcal serine-rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110603.1">
        <property type="nucleotide sequence ID" value="XM_005110546.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856936"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047316006" evidence="2">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110603.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="34178" checksum="504A6B5D4E53A2EA" modified="2025-10-08" version="1">MKTVVLSVCLLVLVVPGFESRPFFFSKVNDFFGSVTDEIVDYRKGLVNSVKKVWKPISDKAEDIGETVVSYGGKVGGGIKDTLSPVGEAVGDLGEAAINYGGKVVGGIKDEVVVPATGVVGSIGGKVVGYGGKVGAGIKDTLAPVGEAAGDLGGVVARYGSAVGGGIKDISGSVAGSVVSTLTGPFERSSSSEGDKQADTSDNSVVSVSDNSAATASDNSAADVSDNSAASASVSASASDNSAADVSDNSAASASVSASASVSASASEKSAAGSSDDSAVSVSDSSAASASVSDNSAADASDNSAASASVSASASASDNSAPSASDNSSASDNSAVSASDNSSVSANSADNVAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K906</accession>
    <name>A0ABM0K906_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111737.1">
        <property type="nucleotide sequence ID" value="XM_005111680.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855305"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005111737.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21100" checksum="6EEA5CDF23A0B6D3" modified="2025-10-08" version="1">MNHPQYHGYGSNLHHHLHHHNNNNSNNNSSNNNSSSRFATATTSTSTTITTEDDVMDIMSSNDHGRDVKEEKSSNHRRLTLPRLSISATYSKLEEDGGDSEGSVASQGKQGIENPGFVEARPDVRQSHVSVTSDDTVSIASDTLKRRNRMRSESAAAIAVLRSSQTVVDADTDMLMSNDISSEVVFNERTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K915</accession>
    <name>A0ABM0K915_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101859829</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111757.2">
        <property type="nucleotide sequence ID" value="XM_005111700.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859829"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053075">
        <property type="entry name" value="TNFRSF11A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47134">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47134:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111757.2"/>
        </source>
    </evidence>
    <sequence length="445" mass="50599" checksum="B23E75160E7D8870" modified="2025-10-08" version="1">MAAGSEEDGEVRTDVYDGQKEERRLREEEAGGGKKEGEEKEDVDSNAMWNTLYKIGGALEPLMPSDRNSNGVCPKSATDSCPSGHQLKQCKTGQGFFCEQCSDKTFQPNENWMGDKCRLRRNCRKANMYYLDEGSTTRNANCACIDGYHFPNEDQRACFSNPICQKGYAPGMYGNCESCQKKGMFSDTVGRVKKCKPLTNCEKRGRCTDVKSNGQFDNICGPKVTDLSTCKEIEPSSSSSDVLKIAIPAGIIGALLLIILFIFFVRRKKYRRQQSSKRVLTVEEMDELKLRITKASDRDPAVCKKVLTTSCSFIEERIERQIWDLARELFRPHHIDGKYELIVDKYKESQAKYTVNGYLLEWRDWRGDSKDAVAELFRCLRQVKRDDIINEICACLRNDIEFSEDSQRQSRHSSNKKSMRDECVYIFFPCCYGGKEKSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA14</accession>
    <name>A0ABM0KA14_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Apoptosis-inducing factor 1, mitochondrial isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100533557</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>A + NADH + H(+) = AH2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11356"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112513.1">
        <property type="nucleotide sequence ID" value="XM_005112456.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100533557"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029324">
        <property type="entry name" value="AIF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031973">
        <property type="entry name" value="Deltameth_res_prag01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF4">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14721">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16020">
        <property type="entry name" value="Deltameth_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01353">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Deltamethrin resistance protein prag01" evidence="16">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="181"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial apoptosis-inducing factor C-terminal" evidence="15">
        <location>
            <begin position="513"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005112513.1"/>
        </source>
    </evidence>
    <sequence length="667" mass="72992" checksum="A320C2AC94336C73" modified="2025-10-08" version="1">MDRVHTLCRRTFALQNLKRIVAQTQVSRTPVVVQARCMGGHHTPDHWKPIKQVVKEQKNHMDFMPVPEGSWQESFNKTQQKRNLMLAAGALCFGITYTICLYKTGCLELHAYTDFSQFKYKTNGSNEGAASSSSEEVQEDNSNNNAAATPDKGQGDAGESGAAGGIEPDLKDLPEVPQHAQYLLIGAGTATFGAFRAIKSKDPTAKILVIGEESVVPYMRPPLSKELWFNDNKEEVDSLQFKQWNGKKRSIFYEPKEFFADPRTLNTLEKGGIALLTGRKVVKVDASKKKVWLASGETLTYDKCLIATGGKPRNIPVLAKADPEVQKRTVLFRNVEDFKSLDRMTQASESIAIVGGGFLGSELACALGKRGKDTGLRVYQLFPEKGNMGRVLPEYLSKWTTRKVENEGVTVLPNHTVSGASFKDGKVVIATKEGGSVCVDGVVAAVGLEPNIELAQASGLEVDPVNGGYLVNAELEARRDLWVAGDAACFYDMKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPEVGYEAIGIVDSSLPTVAVFAKSTEQDTPKAVVEKTGESLRSETENTASPAPLRTPPPSSPLDSEDYGKGIVFYLNKSKVVVGILLWNTFNKMSIARQVLKDGAKNEDLYEVAKLFDIYDTQSEQSAAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAK8</accession>
    <name>A0ABM0KAK8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101855768</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112942.2">
        <property type="nucleotide sequence ID" value="XM_005112885.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855768"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045743463" evidence="3">
        <location>
            <begin position="23"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="145"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="270"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005112942.2"/>
        </source>
    </evidence>
    <sequence length="503" mass="54310" checksum="182345A80F1E4181" modified="2025-10-08" version="1">MTSSASLLNISLIILSVVTCLASTQMTVSTVVSDAELGQWFTVQCQVSGSLGLVVIIQISKDIGSNKTTLVNHIINGNITTDKPPTRISYNSDTYTVNISNANCQDEIVGAERVKYVCDLTYVTTATATATSSKEVTIKARPQEPSILSTSPASLLSDKFVVEGTEVKVTCSANVGRETKGSIVWRIYRNNTPEFVSDARVKSVERTGSPSCTRVMDSTLTVASVSRSDQDLAIACFVVNSDFNAVAPELCSDPAAALCQLTETIRVHYPVKEAFITGDNSATEEGSVTLTCYGSAVPDATYVWFKSGDENRTLSESNILTLTNLSIAEDAGEYNCTASNNVSGTIYSASQSFKLTIVPTTPAPTTTPEATDGPTEPVVSGDTSGDDQTIIIAVCVSVVILIILAIIIGIICWKRRKPRKEIEEPSEKPYNNRPNLSFQNPQPDLVADEKKFNNPSLNNSFDQKNEDGLMYADLTYDNRPRSRKPMALGDAMSDYSDVQMPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAL2</accession>
    <name>A0ABM0KAL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium-binding protein P isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112953.1">
        <property type="nucleotide sequence ID" value="XM_005112896.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858833"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005112953.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15424" checksum="79ADC4CCA5780FD7" modified="2025-10-08" version="1">MSGYPYPAGSVPPPEKSGGPPPYPYPQPQPSYPAPPQYPPQYPPQYPPQYPSQYPPQYPAAPPPPQPNVTYVVNPAPARQSTTTIVYERPRPPPIVRPAVGLGLGIGAGIAMADWEMRHHRRHHHNRGGFHHHHHHKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAV0</accession>
    <name>A0ABM0KAV0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase RNF220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101864503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113134.2">
        <property type="nucleotide sequence ID" value="XM_005113077.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864503"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16563">
        <property type="entry name" value="RING-HC_RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040178">
        <property type="entry name" value="RNF220_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="511"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005113134.2"/>
        </source>
    </evidence>
    <sequence length="563" mass="61227" checksum="3B79074F495BEBB9" modified="2025-10-08" version="1">MDNPSFVPNPLTSPALMVLASTAEGHEAPRLPAPPHPFPGQQGMDKDLPPPPPFSSAGFTMYRPGDPFSSPLYSPLSFVRPGLDRRLALMSPGVRPGAFRPLGPGVDGGEGSYHSAFSPAKKIKSDETSGASSSSETQGAPSSDGIYREECDKSEERESSPGIKEERPSSISSAGYDTISEPLSDSGDAYERGTPDSEGRSLRKQRKRAPHDGLTPCCPVCGLTLRAGELEQHFMLEIEKLDKIARGGRKSRDTTPQGRKSLPSPSGSRKGKDSPTPEVASRSRYDNFLRVRCNRQSRLSARSRNKKSKKPGEDGMKETVCPICSERLAGSADDLNTHVEMCLKQRSGEGEEEAVDVEGEFEEYEWAGQTRVRATTLLPGGFAASGFQTHNSRRDGDEEGELNVDGDDTEEYGKPQFTETDIVPVGSDGGSPHTDIRSPRGNLPPESSFTSRTDTVNADGAGCSKHLSPYDIPQRSACDQGNDDQSISALVGALRAKLQDLEAEKTEKQKCLICMEPYRTPLTSIQCWHVHCENCWMRTLGAKKLCPQCNMITTASDLRRIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUG6</accession>
    <name>A0ABM0ZUG6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MAP kinase-interacting serine/threonine-protein kinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101856005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012934704.2">
        <property type="nucleotide sequence ID" value="XM_013079250.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856005"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012934704.2"/>
        </source>
    </evidence>
    <sequence length="225" mass="25084" checksum="035A5141BDC3A56A" modified="2025-10-08" version="1">MFFLIFDKMGGGDLRGMLESRDCLRLSETEASKVMNALAKALQALHVDGVAHRDIKSENILCKNSGEVTPLVLCDLGLASDLASRSELSKGDISKTTLTSPVGTPMYMAPEIVALMCDESKQPYDTSCDMWSLGVLLYEILFGVMPFQRGCDEHRGSIDFSCKDCKILMYQDILRGDYSFPVNVGEFYSHSAVDLIKRLLVVDPQARYSAAEVLQHPFLTEQHEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZUK8</accession>
    <name>A0ABM0ZUK8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106011051</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934774.1">
        <property type="nucleotide sequence ID" value="XM_013079320.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011051"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012934774.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43565" checksum="99C377154FFECD5B" modified="2025-10-08" version="1">MLGGSSTTNIKRRDATRCTRLCHLGVNESVGDVELTMDLPSYAQSAMCRETTDVLVLEHKHYERLFLRRHPRTIEAMRDQIGVKLTSRLSMLNSKQEIPFLSFLVKIIESRHKGPPTQEREDEHTVTSAEKDFLNHKGPLIDLHGPGSVFFLIRLRERTKRRMRAKRGERTDRYVASTSQSLPTSILMSAANHNGGLHDIGPAYARPRSARGLPTQARSFRLMQSTTQRGSGAESARIFGAGHRDDLEFPDQENILMSPSSNTAIENAEEQDARLSTLEERVRTWLEQDSPRGKAQVAPLRRLVLEDMEFQPKPGNRVFVRRKDIHATPTMTSSSSSTADQPRDSPRQMPRDSPRQIMQQRESPRAKTMIAGESKMAAYNILLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVN3</accession>
    <name>A0ABM0ZVN3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aklaviketone reductase DauE isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101849828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935499.1">
        <property type="nucleotide sequence ID" value="XM_013080045.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849828"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012935499.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="32920" checksum="E4221566494681BE" modified="2025-10-08" version="1">MVLKLPWLTVCRKIKGIITYNSTYPMMDRLSLLDRVAVITGSSSGIGEATARLFSKRGAKITIHGRSEEKLEEVKLMLLQNGSTSEEVHTVTGDITDPAVREKMVEETVQKFGCIDILVNNAGGGGQAGFLRDVTEDQMDFAFNVYLKAPVLLSKLCLPYLVKRKGNIINVSGITATEVWPGAFPYNSFAKAGLDNFTKFAAAEFGQAGVRVNCVRPGVVVTPSFNAAFPDSSVREQFLSSCAKRTLLDFNGAPEDVAEIIAFYASDAAKFLTGDFTCADGGRSINCNHGETMPQPNYDDFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZY41</accession>
    <name>A0ABM0ZY41_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101849920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012936898.1">
        <property type="nucleotide sequence ID" value="XM_013081444.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101849920"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF547">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045004525" description="Peptidyl-prolyl cis-trans isomerase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="46"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012936898.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27278" checksum="823FE2DFFC2651F3" modified="2025-10-08" version="1">MFLFLLSAFTTLLALGACDKNFTVTSEVVLEVEVKNYNGQGDDISGQVVIGLFGDTVPVASLNFKTLCSGFKRPSSQINAGKSRKARRQQRQVGGFGDGEEVKLSYKNTYCHRLVRDMLLHCGDVFGTDGHGGTSIYGESFNDENFIISHSSGGVVSMANRGKDTNASQFFITLGSARFLDKRHVAFGKVTKGYQYLMAINRMGPQDKDVRPKRPVRFTECNVNEVKKYELSVKDMKTDDLEGIVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZYK6</accession>
    <name>A0ABM0ZYK6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase Era, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ERA-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012937206.1">
        <property type="nucleotide sequence ID" value="XM_013081752.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850950"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22534">
        <property type="entry name" value="KH-II_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046646407" description="GTPase Era, mitochondrial" evidence="6">
        <location>
            <begin position="20"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="7">
        <location>
            <begin position="109"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012937206.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54398" checksum="063A057A0203CE46" modified="2025-10-08" version="1">MTWCIVRWLCRQGLPLVAGAVECPGSLKQKLLQRASLNFFKQRCVCFTSLSKDNAEVEKSNNPSSFSEDSSCTEEFVVDGERMVGRTSDLQERISLLKPDSPPDSKVLRVAVIGRPNCGKSTLTNALMGWRVCSVSDKVHTTRENTLAVFTEGRTQIVFVDTPGILQPGSRKRHKLERSLEIDPVRSLASADIVAAMVDVSCRAAVRCLDPGVMRLLYMYRHLPAVLILNKLDLMKKRDELLQTVRILTDGVVAGTSLEQRKPRTNRREKMFAAVDEKLGVAQKPEGEGNARTGDDDDDAIPAELRAPVDEAVRSGELSWDQYFNELRQATRVVGSRRGWPLFDQVFSVSSLRGEGIKELKEYLLEGAQAGPWPYHSSLVTDQRPEDVVKLSVRQALLDNLLNEVPYRLQLDLVLMEIDPEDDLLNVVVNIQCQTERQLTIFLGRDGSMIRKISSQAKQAMMDTFRCDVRLKLVALLKHTTSSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ05</accession>
    <name>A0ABM0ZZ05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin cytoskeleton-regulatory complex protein pan-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101863017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937449.1">
        <property type="nucleotide sequence ID" value="XM_013081995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863017"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033741">
        <property type="entry name" value="SQSTM_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16577">
        <property type="entry name" value="UBA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="401"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="543"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="664"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="697"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012937449.1"/>
        </source>
    </evidence>
    <sequence length="797" mass="86071" checksum="D1DB048658684EA4" modified="2025-10-08" version="1">MSTSQVGDIVARAVGAGDIELKVKRQPGLDEDDEEDEDFSSDEGEEDIASPGYKSSQMNNTEPKGFSLQNQLEEERAWLEQQMAGATSSIKKEQQREPEIAPPPEPLPYTNSGYDIEVESRQTITLSRPQNKKTDDPETPSPTNITHSPGSSVALEEDSDGSSYGPPAILRKWQRQRQKEEYTFENEPPTTSPSLYKKISLNASLPKRDFDSEEAPTERENQSSVSSARTSRPWDEGMDEWTQGQDKDRMPLGTAVDGRSDTVTEAKFQLEQERMRNQYEEDLRQAESKEQMRRQQEEEMLQPEMDKTRLLEERRAERRARIQKGAAAASSPSSSPSSARDDFPSAASPQPTGPDQNSYQTNSTHVTSMTLNIAPQQQPQQQQQQQHQQSSSSSQGQGPIHRGVTCDGCEGPVIGVRYKCCVCADYDLCSCCEGKGLHSEHDMYKITVPRVNPMDFIPPHFGRYLNRYMQGYWNGSQAGASASASASASSSSASAQASGGTGSGDKAKEQAGYDEYLKGVGANIAAFLDPFGIDVTYDVHHGDGSHETGGNRRGNCRGGFGRCGAWGSNMRRRAETAAKTPGAEQATGKGETMETDSAEKTQDQGAQSQTAPQDVPMDESNKPSASNNYGGVSDDWTFVPEDGTEVLIPTQAPIPMPGPTAIPMPAPAPAPTPAPAPTPAPAPAHAPTPAPAPAPTTPTSAPTMTAPGTETPTPAPRVAAPTASATAPAPAQPGNQTNIYPNLRIQQSLDQMLSMGFTNTDNWLADLLTEHNGNIGAVLDDIKDKATQQLNNLRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZZ26</accession>
    <name>A0ABM0ZZ26_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat serine/threonine-protein kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012937476.2">
        <property type="nucleotide sequence ID" value="XM_013082022.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864296"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="COR" evidence="2">
        <location>
            <begin position="67"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012937476.2"/>
        </source>
    </evidence>
    <sequence length="180" mass="21035" checksum="7C34158BD6B3D188" modified="2025-10-08" version="1">MMRLVTKMFLSNQEPDKSGLPNILLAVNVSCKTGENVKRLVDLIYDHVFELKHPRSRTQYLVKQKIPRKYLLLQNIVRELAVERVNAAKEPVLNRSKYTLCVQNKMMEKGVTFRDVEELEQATRFLHENGVLFHYDDLALRDLFFLDPQWLCDQLAKVITVREINSFAQRGQRSLCCCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A123</accession>
    <name>A0ABM1A123_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101863106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938662.1">
        <property type="nucleotide sequence ID" value="XM_013083208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863106"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="7">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012938662.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35255" checksum="20ABAF179F1450B4" modified="2025-10-08" version="1">MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFIPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACAPRHGRYLTVAAMFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1X9</accession>
    <name>A0ABM1A1X9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101851740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939162.1">
        <property type="nucleotide sequence ID" value="XM_013083708.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851740"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11557">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012939162.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="67574" checksum="05D0BD5589F60093" modified="2025-10-08" version="1">MAGFLSRSFDKLKSWIYGLGYTGLWLFWLCLLLTVIYFLRVPLKLSENVSYATMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFKKYGTSFIEQVSLNHISPLLGGGDSAAEGGGAIAGGGGASSPATNSTSNGGVENGGGGRSSSQQSSLPGSLFDKVKESQRRIPEPVIFRECKVWRNPLNLFRGSEYQRFNWATGKEPLTYYDMNLSAQDHQTYFTCDADTGKPEYEIMQTAWRERNPQSRIKAAHTALEKNPECATAMVLLAEEETTTILECEKMFKQAYKAAETSYRKSQTTQHQNSTQEALHRRDMNVLVYIKRRLAMCARKLGRTREAVKMMRDLLKESPIMNFNIHENLIEALLELQAYADVQAVLARFDDISLPKSATICYTAALLKARAVADKFSPDIASKRGLSTAEMTAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYSFFHLHHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFHPYPTCTENADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTALLALLTHQYPEPMGVVVRTMLGWLYLPLSYVLEKLEAILPSNLLHQLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2P2</accession>
    <name>A0ABM1A2P2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101860465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012939630.1">
        <property type="nucleotide sequence ID" value="XM_013084176.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860465"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044955425" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="31"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012939630.1"/>
        </source>
    </evidence>
    <sequence length="601" mass="66618" checksum="0905ACEF540840BC" modified="2025-10-08" version="1">MNVFLFLVVVVGGVSGVLGAPFEKNTEPQYTTVTTLYGAVRGVRQQISPGKALDIFLGIPYAKPPVGQLRFARPQFPAPWKDTRDALKFGAQCAQRPLTSSPQADLPYSEDCLYLNIYAPRFNTSTVKLPVLFWIHGGGYFGGTGALYNGTELALRGVIVVTINYRLDLFGFLSTADSVIPGNFGMLDQVLAMEWVRDNIAAFGGDPNDVTLAGESAGASSVSLHLLSPLSRGKFHKAIMESGVSLCPWAWNHSNVTYYAPKPMANTLGLGVGCSHEDSHELLSCLRRIETDYLVNTSIGLQKTLRDAMVWVPVVETTFGFLPNTPEILLQKGLIADVPTIRGYNKNELALSVKDPEDQGYSIEKFGELLILSAYFFFQKDIVATVAEIELVYRRNQTSAKGRRSDYERLMSDYYMIAPISYEAQLHSKLQKRSKSYLYEFAHRPTFTSLAPWQGVVHTDELAFVFGLPRGPSQLAFNTTDPGDIKVADIMVTMWTNFVKTGNPTPPPPPLPPTPEQSHKEDVIISHYAEGELKELQRGERGRHLGAKPSQISDVIDFVWPALNDAYDSVLEINTATAPGKYLRVDAEQLWMVRIPRIQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A316</accession>
    <name>A0ABM1A316_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger ZZ-type and EF-hand domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101846362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939826.1">
        <property type="nucleotide sequence ID" value="XM_013084372.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846362"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040099">
        <property type="entry name" value="ZZEF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22772">
        <property type="entry name" value="NOVEL ZZ TYPE ZINC FINGER DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22772:SF4">
        <property type="entry name" value="ZINC FINGER ZZ-TYPE AND EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DOC" evidence="8">
        <location>
            <begin position="216"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="1876"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="1925"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1044"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2407"/>
            <end position="2503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1044"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2425"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2443"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2484"/>
            <end position="2494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012939826.1"/>
        </source>
    </evidence>
    <sequence length="3038" mass="337555" checksum="EAE46D3F1A71CD00" modified="2025-10-08" version="1">MGNALSESDEEGRMEAPNDPEDDTSDGEDNSDGDSKPATDLCYLFTDQSSLRVAATKVKEKFPEVALLLYNSQIIQWLESRADIYEDSITQAQFCDMLIGLGVERAEAIKAFHQFDSDGSGVAEVAAMIEAVAEYSNRSALGELGKSIRTLQSCALTPGFVDVYAGSSHPVNKHGSCILKYLLRNRAESASLPFPFLNTFNNTFIMRSVVLKNLLNAAKDDLKENELEGDINDFEKKTIHNCYQSLEVSSNASESNLSRHGRQGTMFWQSDGAARSHFIRLRIKPNVVLKTLSIGVMATDQSYMPELVTVSVGQSVGNLREINEVKVDSHATGQVVVLRNMKTYYPYVQINIKRCHGEGCDTRIHGVKAVGFKLVKEAGISVLDASALWYLQMLTTTVSVNLVQSPALRTMLLEHTKKALEHMPPLVLSSMSSSRPAFLSKHVLHELEVFAETLSQSTENPDQLTVDGLQVLLALNFARGSVAGLIRMLHRFKELPSVSLPCAELLSKAMINRNTCWESLGTPISVSLLASDGGEGSANLGPEVVIESFSASSGKTASSSPNRAYVTDEGVTKCTMIFKSEENVKLTKIKIQVSPGNKGARHGLVFVYNPDTIPELSEKFDKEEHMNFFSKYDFWRSKEFEFSIGYRKAGLGGMPDNPVAYFRFDNDCDMLDVPVSWDAVGQYLLVKFLEPRHESATRLGIVSVRFSGISRQAAMINRLEKPLAMPDPAKKSTCDLPEIMATVLTFITDLATDQVRRRSMFRPQFEFLDLSDLDATSLWELHLACEERLKEEGLSTKVFNQWQRSSMLLLQLIHGLIPVLASSKATSEASRDALFQQLCEIVNTQSEVEVTPATASSITYVDKLNMIRQIIIDGAPLFFPEKTKKRDELFKLMKTEIHTHTFTCSFSHTHKYTQTPKSMETDFSDQSSQPSMSLVFQSLCQFFSSVDPKGLLDLPSKTATNLCAANTLDMMRSLLVVATQEQEGLHLTSHTHRRQPTPTTPSTPTATVTTSEIPAASPATTTTATTTSVPASVTTATATTSTAATMSDLTSSTCPPPTTTTSAPPTTNACTPSSTPLPASPDVKTQLSKDLPERSPESPCSAPLKAVGAGVGEGEGTATGAKTSEVVKPVSESGPQMTYLVRLTASLQTALFSWCWQQLEATVPQEEEKFYNFVNDIIVTYSCEVAGKANQYFEKFKSMSFNEVKAESDAEEPSFLFILVRQMMLLLSSVVDHLNMSSKVRLLHDLKPLITAVTEVARNNPELFCDICSTCWDNLETEETTLRTWEVESPHDYHNHSNINQTFHCPGASKLLVEFDPRCETERRYDYLEFADARGLKLRFDEKVGTGRWPRKVTFSGPYVLFSFHSDSSNTDWGYKFTVTAKGDPDVPLSWLSDLHLSVVKLLGQLSGATLSSNPIMLYENPGPTEDLVDQDILRSELWTSLFRGGYIVGKLQRSLSGKFATGDESRVSSFLLEVLSVEEKGEESAGNHTADGSFRKQASRFLTKCQEAFKAKNQQVQVGGEKVSRAVVALFTALVWHCQALREDTDKFLSGGDLGEVTEGITQAYVTAESVRLNLTSERQKWNNSEDRTDDTDPAEVLTAKASFLLKFSGLTKMQMRSEMRSKLHKQTLMKKAGNVRPAVVRNEIMEKYPSFRLVMEFVQDPAWTAQRVHQLLQERVQFAGAVSDVFMYAAEMIRIMSAHSSPFQIPLVLYFREMLAYQEKFAKHYAHGLDGCGLDLEAKVRCAYYSLVRRLVEMFRSPTVSQQLDSKRVPACDFLKCCLLHLLDVEWQPYDLNFVVDMELPRLYMSIAKETVKMRDLNTSDVKEEDELLQYDLSMKLFSEIKDDFTEWFARRHSCNEDKKELKMFVARFSDVIDVEISCDGCGVTLPGRRYRCLQCDDMDLCTSCFSSGVEPEEHRDDHEIVHLVYKCNHCQAFIVGTRIHCNQCDDFDLCLGCHIKQKFPSGHTEKHDITKIPMVKLKTSQSSNSSLKTYVHQHVWMLYTSLTLALSDIVYGTEPGAAYLDSDYIKMAGLLQQQCVTQATLCLDHVTKEIDGEAEKEVPVEKRREQTFAIHSQERIMGLLGAVMPSGEHRERVAGTGFNFWTKDFLDRFLRVSRGENGYELNTQHLALRLLGRLLANGEIKATKKDDGGQGSEDEGAALLGASADEVKAIPSNAQIISRLFYFGTKSFEKSSVEWACSVARMLEMLSTTPQWGPVIDQHVAQCVASLKATVTVSSIFPMFVIAGFPEVLTTGTLVDYSSSVEPQRGVVLKHFPDKYQTLLVDLRTRKRHTVKDQQVSCRAEVTEILEQDTLAKFVSFVIASVQRIKAGEELSVETLWVVSLALKVLNRSLKSEGMCGVGGAVFTGTFMQALVYLACTGTGLNQNWRQKDLEVLSLLLYTHDGSAPKKTKISPLKEKKKKKGGDKEKNEKKSDDSDGMNNVEDDDDDDDDSDDEISLSDSDKDDNDSNDDDDEPGWTTTSDSDYEDADEEPNSTETPQDEGAKQLMGQQAKELLEALHQELAIPEPVLEALCAMNEGSPEGIIKSILENFGGDSENVTEFLTKWKAKQAEAPEKKETTSENAAIDTGITTHANIGETHRIPETATAEAGDNPQDLFKQQGLLEDEIGERMRSKSAGLLKRELDKHGRTGSRDYLAKVNLALTVLYARHALTSLLASWPTDGPAINSSLLGCKDVKQIPCVLDLLYKIDTRNFITKVVDRVIHQCDAASLVPIAYTAAQFMEEVTLSAVSRESAHPYSNRDDKKKGHIQLAGAPYLTVTFDSKCATCDEDVLTFSTRQQLDKDVHKFSGPFRSTWSSFHIPGDTLYFKFTMNEYADYLPRFGFKFTVMPGTRDSFETGHAILQAVLSSSVARSLPLGQLWSSLVYVACRQPGLQRLKAISLMIKILTLQSRSGPSQESSGLSIDLHLVKPLWELYRGMTREGEEANVAQPAVVRALTDLFLHTENLAMEWDVSEAYIVALMDVSDVCSSIVQGLTNVAAIGQMIGHENAATEFITKIRSLMTDSKLMTALKAEISKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A327</accession>
    <name>A0ABM1A327_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106012199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106012199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939842.1">
        <property type="nucleotide sequence ID" value="XM_013084388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012199"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="332"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939842.1"/>
        </source>
    </evidence>
    <sequence length="768" mass="88759" checksum="DA646CC35D1EA454" modified="2025-10-08" version="1">MQKENQENSFMCEQCYRKFDTWRGLRVHQGKVCLKKRRQCRSSDCKTRSKSSQDENHSGPISASVDSPFTLSQQEMEQQTEPGLRKPRILWPAANEKAKYKTLEEEVQKKLKEVKKSSNRGDAKEILSAFATIIYDSAIKEFGICEGKKKTEKKSGLSRRQRVLAQLRKQKRDLQKQKKYAPPEEIEGLRILFEDLKKKSRDLQRHERRFTRRKERKREREQFLKNPYEAAKKLFTEARSGKLECTKEELDAYVKQTYSDSRREEPLPYMRGLKRPAAPVVKYYLGPIREKEVDEFVKKARAKSAPGGDGVSYKVFKYCDTLRHTLFEMLRGLWKDKEIVKDWCRAEGVYLPKEQNAKEIGQFRPISIINVTCKIFMGILAKRTVAYLQSNGYVDETVQKAGVPGIPGCIEHAFTIWDTIQEAKKNKESLNVVWLDLANAYGSVPHKLLMKAMDFFYVPQEVQNIMREYYSNFQMRFSTANFTTKWHRLEIGIAAVCSISVIWFILVMEMLLRSAECCEEEARVRSPKKAFMDDVTLLTRDGDTMQSVLNRLDKLITWARMKFKAKKSRSLTINKGKQKQLKFTIAGEQMPTVKEQPVKSLGRWYSGTLSDRSQGVEIMKQAENGLKAIDQTKLPGKHKIWCLQFALYPRLAWPLTMYEVALSRVEMIERKCNSYIRKWLGLPRTINTSSLYRHRGALQLPLTSIVEIYKADGRYSRTTSVDASLPSLFLSGLMFSQGNLHSLSNPSDVTELKQQGDCGIHDNNGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4H3</accession>
    <name>A0ABM1A4H3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arylsulfatase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101852941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940677.1">
        <property type="nucleotide sequence ID" value="XM_013085223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852941"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045037887" evidence="7">
        <location>
            <begin position="20"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012940677.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51773" checksum="7FE8369B2266D015" modified="2025-10-08" version="1">MSWLFVIFPFLILLTETNSKPPHIVFMVVDDLGWNDVGFNNPDIISPNIDSLAHDGVILNHAYVQPLCSPSRSAFMTSYYPFRLGLQHMVINNAAAVCAPMDKTFLPQVLKKNGYATHIVGKWHLGFCRWECTPTYRGFDTYYGYYNSGEDYYIKVQGESATYDPKTFVYVSLQVPLHYYNMYPNITNDGRRIFSGMVTAADDVVGRLVKVLKDRDMFDDTIFFFTADNGGWIPYHGNNFPLRGGKITIWEGGTRVPAFVHGKPLQKTGVRYDGLMHAVDWFPTILEAAGISYSDPHRDGISQWQSITSLSASRRSEFVYNLDNYTTPNQGHAAIRVGDFKLIVGYPGLYNDWYKPEEDWPGPTPSSDYSDLDLQMDPHTYSNWTKFRGLYNIKDDPYEHNNLYDKLPEVVEKLKARMSHYYTMMVPANYPPNDPKADPNNFDLWWQPGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4T8</accession>
    <name>A0ABM1A4T8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101845709</name>
        <name evidence="9" type="synonym">MED15</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940853.2">
        <property type="nucleotide sequence ID" value="XM_013085399.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101845709"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048386">
        <property type="entry name" value="Med15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048385">
        <property type="entry name" value="Med15_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019087">
        <property type="entry name" value="Med15_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31804">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31804:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21539">
        <property type="entry name" value="Med15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21538">
        <property type="entry name" value="Med15_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09606">
        <property type="entry name" value="Med15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 15 N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ARC105/Med15 mediator subunit central" evidence="12">
        <location>
            <begin position="294"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ARC105/Med15 mediator subunit C-terminal" evidence="13">
        <location>
            <begin position="434"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012940853.2"/>
        </source>
    </evidence>
    <sequence length="561" mass="61559" checksum="A598523A090C384A" modified="2025-10-08" version="1">MADPNEWRTQAFRTRIVNKLEDVMRNSQTQMPKSSVEMEEYVFQKAHTRDEYLDLVARVLLSVSEHNSKEKKAPQGMGVPNMGQPGMAMGPAGSMGNPQQPNMAAVQGQGLPDPINALTNLAGQGGSGMGMMPGMHNMGGASRPPQMMDPSHMMTSQRMQQHPRSQIPQKPAQLTRQDAFLVTSPQTMPGAGGQALPASNANMIYQGAPVRSMGPMGMPGQYMAGRDAMTGMPIQTPPQGSPMTIMSPHSQPSMMSPPMMRPPMVGAPSPSTMLHTPGTSVSNPSPGPPSTSQEEMEYLKKLENLSKYIEPLRKNILENEKKTDEESKKNQKKMKNLLDILSNPKKRVPLPVLEKFEMLLLKVHPTGSSSSANGHMCQPLLDAVAQFSSAASLNHSLYRTFGPALEAYMGPPIKAPSPPPCKKRKLEKDASEELPDILQGEIARLGRRFIISVDPRHHAGSESHHLVCKLEELRLPSVPPLMVSVPKTYPRFSPQCEPATCPGYDATEFFQNVEQNLTIHISHMPNRFSLTQLLSSWEMSVRKACDPENPVICQPNPIYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A598</accession>
    <name>A0ABM1A598_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fibroblast growth factor receptor substrate 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941091.1">
        <property type="nucleotide sequence ID" value="XM_013085637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853714"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01202">
        <property type="entry name" value="PTB_FRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038742">
        <property type="entry name" value="FRS2_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF55">
        <property type="entry name" value="FI23523P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="7">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012941091.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28677" checksum="A1DB945AAFB87242" modified="2025-10-08" version="1">MGCTYSGQSSRNEGAVRSFRVHNVDDQGVKLSRGNIEIRDNDLLLYQKGKEPIRWPLHCLRRYGFDAELFSFESGRRSATGAGIYAFKCAHAEALFNLVQESIQRAGEEAQRGQQPQPQPHVNHTVAAPPGNQPLMDWGVPVPGGPPHHHESFSHFVPPPGADDSPDMQHAGREGSSHLYVNGVVNRDNPQHEYLNAGPQVGAIGAFQIDETAALIEFLHHPPGFGGGNGRSQVNYAELYMPEAPASVENLVEEAMDRKDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6Y6</accession>
    <name>A0ABM1A6Y6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEP domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942047.1">
        <property type="nucleotide sequence ID" value="XM_013086593.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853597"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206">
        <property type="entry name" value="DEP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206:SF19">
        <property type="entry name" value="DEP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="47"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942047.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="63572" checksum="25DFB3CAF912AD8D" modified="2025-10-08" version="1">MANALGTSDPQSPQPGRFERAIPFRESKGPLGPFKATKIWKALIEHLRAKVELKRRRYKMRHIESCFTGTDAVDVVLHFLLSDRETFSADLTREKAVKVCQLLMHRKVFQSAVEKQKSDKPSNFEDSSSKLYQFLGEYVVGPNFQEDAEEEEEEEEEEVSFTETSNEALHKLTPCLEKMRISDHGLDPEEEPAMPTLSPCCKPLQEIHENNLGQQSSGAASSVTAGGSHVDSVILEKPMRTLSSAEVEETWKEVALTQLLTLVDLTFLDGILSEEKQRSRQQQRDHLIISNIMARNWHLPLMPSSLDAPSDPLLQTAMDCIECLPNGLNLLGEPVFKRRGMEAKLWAKDIIVKHYASLGDCLLPEKFMELHVAILNLILDDHRENALSALQLYMILLPPAAREELYRLLKFMLSLSADDTLRLDPQESNEITILSLLSSSIFQHKLLAANLAQKLVQFLMNNIDRIFIIPREVRKKVAGRLHELKTGKPLLSCESSFCNRVSVEEFERQSKDCTEESLIDLMNTVLDDTKISLKDKKQRLKLFQKSYPNLYEQNFDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7X9</accession>
    <name>A0ABM1A7X9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-crystallin SL11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942559.1">
        <property type="nucleotide sequence ID" value="XM_013087105.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850197"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942559.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24452" checksum="C240A7886842F9F6" modified="2025-10-08" version="1">MSSPNVKIYYFDMMGRAEMIRMLFAVAGKQIENIRFSWEDWPKSFKEKAPFGTAPWVEIDGEVHAQSMAIATYFAREFGFYGKTNRDGLLIDQVLNLIHDFIEVSIVVYDEPDKEKKAQRLKDCQNKSTRLYFGGFEQILKKTGTGYVAGNQISLADIAIYDVVTGWMKPFLGPIDEFPLCKALLEKVAANEKIKAYMATRPYSSEKEWGDLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A973</accession>
    <name>A0ABM1A973_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carboxypeptidase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101854047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943223.1">
        <property type="nucleotide sequence ID" value="XM_013087769.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854047"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03868">
        <property type="entry name" value="M14_CPD_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF73">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045747002" evidence="9">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="10">
        <location>
            <begin position="34"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012943223.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="45249" checksum="BC2A404FCE886890" modified="2025-10-08" version="1">MALFSQLLLVLSTLTLARSATLGSSVVDGLDFSSYHDYPAMKNALERLVAKYPSLAKLHEIGTSVQGRKLYAIQITDYVNTREIGEPRFKYVANMHGNEPVGRELTIGLAQYLLSRYGTDHRVTSLVDNTDIYLMPSMNPDGFEKAYEGDCNGLVGRANHNGVDLNRNFPDQFSSSTSLIQPETAAIINWLKTDPHFVLSANFHGGSLVANYPYDNSPYGYSQGFYSKSPDDSAFRSLAYTYSKAHATMSLGHQCQGDNFLNGITNGAHWYEVSGGMQDYNYLHSNCFEITVEQSCCKYPKASTLSSYWRSNKESLLAFMEQVHTGIKGIVTDNSGAPIANAKVKVYGINHDVVTSSQGEYWRLLTPGIYSVTVEASGFKSAVKQITVTSGAAQIHHVTFDRATRTGSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9X7</accession>
    <name>A0ABM1A9X7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943649.1">
        <property type="nucleotide sequence ID" value="XM_013088195.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852727"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012943649.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="29332" checksum="B51A776425B39DBF" modified="2025-10-08" version="1">MASSGSQHTEQLKDKVCVVTGASSGLGESIAIMFAQRGASVTLCGRNEDRLQASLTLCVQASGGQADRFLAVSGDVVDPSARKAIVEKTVEKFGRLDVLVANAGVTDPQSGILTASEETFDKIMNTNVKAVFFQIQEAVPHLEASKGNIIVVSSMSTLMACSPNIVYPMSKAAVDHMTRCLAIDMGPKNIRVNAVNPSLIPTRIRRDFAPDEETLDKLYAQALVAEISKQPLGNVSVTKEAVAEAVSFLASDAASFLTGLCMPVDGGRSFTGTFGNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AA58</accession>
    <name>A0ABM1AA58_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101864095</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943769.1">
        <property type="nucleotide sequence ID" value="XM_013088315.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864095"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943769.1"/>
        </source>
    </evidence>
    <sequence length="606" mass="66872" checksum="4E79F2EF6AFC0D00" modified="2025-10-08" version="1">MRILVFLDRYAFVCNNWLSPTRGDGKTTRHIPVLDTSLADGGSLFDILSKRKLYNDHLWLSVAKRPTYSVFSRVQRFLCAVALLYLAMITNAMFYQTEQEDGGNSSSSDVQNSGLQIGIVRVTYRTVYVGIFSSIIIVIPGFLMTCMFRNRKLKLSPSQKLGVRAQSSKCATSTSSSSPSHTGVSEPRLGPNRTQLNEAEVNYAFVEDEDGSNMVTNDSKKNDLKELFRRLDANTEGAADIFECSKIGSKEGLGTEFDQQNVEGRDSSANVSSRTSSGKIRTPTDIQCAEHESLASSDLSRASTGKVPTPVDDRESVASSCVSRISTVTGVVENDYKPRHVTAKYSSLKEPPTPVMAELTAHSLPGQEKCDLSRVPTFTSTGFMSLYELAPSNCSGTSQNYSPKYVPKTDAGGVKGDVPSPAHYSLKSNVKSVVHYSDTIETFDVIRHQQLVHRKKYEVKTEDEESMKIKGPSCLLPWWSAIVGYCIVFLSIATSASFTFFYSLEWGGETSLQWMASLFFSATTGTLLLEPLKIVLVALLLTCLLRDSAQNELAEIAPVTSDCDVVAPEHLQAQWRPLLSETEATEAETEKSSKDIEKERKQLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAB6</accession>
    <name>A0ABM1AAB6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty acid-binding protein, adipocyte</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106013247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943884.1">
        <property type="nucleotide sequence ID" value="XM_013088430.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013247"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="16"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012943884.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16560" checksum="FA78EBBE75A3D1BE" modified="2025-10-08" version="1">MATLEQTITGITEKFAGKWKEVRSENLEAFFVEMGVNFLIRKMALQAKPEAEIIVNGTDISIGFKTTFKSDSFMYKLDEEVEITNDKGKFLCTLTYTDGKLVTKAAPSPGNNSKPMETVREINSDGEMETTFTVGQTVSKRIFARLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAL9</accession>
    <name>A0ABM1AAL9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Eukaryotic translation initiation factor 4 gamma 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101857906</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD. Interacts with DAZAP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944047.1">
        <property type="nucleotide sequence ID" value="XM_013088593.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857906"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11559">
        <property type="entry name" value="W2_eIF4G1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 18" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="MI" evidence="16">
        <location>
            <begin position="776"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="W2" evidence="15">
        <location>
            <begin position="960"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="528"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="701"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="744"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012944047.1"/>
        </source>
    </evidence>
    <sequence length="1143" mass="128615" checksum="4427DE17940496D9" modified="2025-10-08" version="1">MSVLDTFPGDQTQERKTVVLVHGIPGQATNFDSLITKLHDMDIRAIAPSDIGSQLSPYNLTLMPNIDFTTSGRAHRLRTVLKELNILRIDLLIGHSAGAWVVYEAIAGGLRVGSLFLFSPNGAEPNRPPYLVIINHCLIWFAFFPLIEAYVIERISSILDSQSSKGGVSPHLGGRDERPPTLKSGSGVTASSANNRWVPPSSAPRDGVKPKDKNDQIFRRVRGILNKLTPEKFDKLSLELLNVGIETQVILKGIILLIFEKALEEPKYSSLYAQLCHRLCEDSPNFDPQTSSVTTFRRLLLNKCQDEFENRSHATEVFDKKDVRLTEEECEQYHIVKKKMLGNLKFIGELGKLQMLHEGILHKCIKQLLEKKKNAQLRDMSEDLECLCQIMRTIGPRIDTPKARAWMDQYFERINQFALNSELPSRIRFMLQDVIELRDNDWKPRKIANETGPKTITQIRQEAGVNGRGSQNNQSLLQSRMMNMGNIPGTNWKGGMGDIFSMPVGSMSNAIGVGPGVIQMDNFSSMPNNFNNGMNRNRFNQQNPSYQNNFQTNFNNKGRGKSQQEGSGSSPNNQRRNNQGAYNQQGGNTSGHGGGGSYGQQGGGYGQQNFQPSHHFQQQQNKQGGMNRDLPPRFQRMVQQQTGPGAGQGGRESGMGPNNSGSAPIGAPGQPSPSTSPPLNLAPPVNGIKEEVSLRPVKNFTMFKPNTPSMLPRSAQAQHPAPRESGFVAKKSTDISEMLNPLLDKQQQQQQQQQQQPTAVKQIRDEKNKSPVKEKLTKEKMIDRLSYLLSECYVSHSLADTVADIKEMNVPRKMIPDLLAQIMLESLEKTDAEQELSMKLIDDLRSDGVTSADQFMQGFKQVCNQMSELETDVPLVKSHVARFGAMALTLGLVSLTELAEPLENGVHYPLFLLCLQHTHKIKDKQWLVDIFNQSKLDLQSMLPELDQNKERMLEILEDRGLSFMFPLLRIQSELGRQIAAEPTATAVFKWVKDKVDTSLHTDPGFINVLVTAVLKFITSESTMKDEVDITVTPEKALMDKEKELLEKLKGVLQLFLHDHTNLQMAALYAVQVFCYTNQFPKGMFLRFFVNLYDMEVIEEEVYLRWKEEVNDQYPGKGKALFQVNQWLNWLEQAEEDDSEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAS6</accession>
    <name>A0ABM1AAS6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable LRR receptor-like serine/threonine-protein kinase RPK1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106013312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944131.1">
        <property type="nucleotide sequence ID" value="XM_013088677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013312"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012944131.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21687" checksum="6DE4623A29A56FEE" modified="2025-10-08" version="1">MEISEEQNHVLGTFNLDKGPCLGRGGSAQVVLAFDRKDPSSKVAVKIISFESGKQAMVDQFHDEVSALRCLSHDRIMSLVTYASTPRQGFIVLKHYPHGTVDKSFPVESSVALGYVADVARALDYIHRLRIYHQDVKPANIFLDDDGRAVLGDFGLARRLKDGEKKVTSWVSTCGFYGPETRTGRCMCPFKPLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AC51</accession>
    <name>A0ABM1AC51_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ral GTPase-activating protein subunit beta isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944890.1">
        <property type="nucleotide sequence ID" value="XM_013089436.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846926"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1293"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="718"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1312"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1327"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012944890.1"/>
        </source>
    </evidence>
    <sequence length="1520" mass="170340" checksum="217215D348F1F876" modified="2025-10-08" version="1">MYWDWASLQEEIQCDRGNQSVLHKFPASVGREVACHVVKHIAQSLSIASGTDEPSSLQDEKDVNWTMEVLCFGLGLPLTEHETINNCVKVYVEWLTALVSPKPCVPRPIVEDPNPFAQVMLHHLLNLFTPRPDSGPDLVNKQAVLCHRVLRAIETVAKESTILTRETWEVLLKFLLAANDSLLSPPTEKDVIGLSNDDISDHLCDRVLSVLFLIWLTACHKSFPSPSLWKTFRSMCLFWRHHEALVTMWHRVNHALTAQMLKIMYGPDFPDMTIGEEESQLLPVDMNPESVAQCWFRFLHILQNPVDLSRPGVVSNTPKFLQHALTSEAVVDPSYHPCLARLPLVFLRAMRGISAMVNAFLGLPQEMKMESQVSEVLPNVVGSKVVTTPSTPPGQRKAAKTISVLTGTLATKVSSKSHAAKNIAVPPSNSSTVEKLLLDTRLPYAPQRPHCNSILHLFAAWLFDASLVGVKLHPSHAAPAKERRTSSFIESKHSSLSMDLNTDPNQTRDVAYQAGRAEACGALCRIFCAHKTGEFILPEYYSRFYIVMYYGLQTDEQSISGEVLSNILFNSCSLLRVDLAGVQLLLPHILKAIELVLNRTAPDFKLCEQIPYTELRKASIHLLLSMLCLPLHFKDLQIKDILKKDDNQPTVTFISLRTRITELIRVALTNETDSQNTQMLLGGFMLVVEDLATCEQADNIPLQPQQDYSDTDLHPDTSRTSASTTSTETNSFQDTSYHRLHAPPPKNLDTAYGLFGHATSLVCNRLMASWKTDLNVALAAMELLAGLAKVKIRPANMLMCKRTVKWMCDLIVFQCSRPAPSHSRDLHSMLCAAFKCLQLWLVEHCSLLYDRECLHQVLEVVELGISGSKSQTKTQEMQTVKVKIDKESKSVSMKNRASDPPKFKGNKELMPASMRVKDAAEALLTCIIDQVGAFPPPCGPESLFSLLDERSLLRFAKGSSLPEQGSLFRYFVIDKSVIVGLLEQPLGNIEDPLPTVTALIRGAFGRHAWTMQLRHSPRASKISSRAHLSDPGRPIPDNSVGVQHNVKHRYFPENVNRIPQTKADKSIPVLESVLTEKQTEDAEKMKGLIEQVATFEREVSHRARLEREKTPYPDPVTECKPPKICNEYQTARLFLSHYGLLSLEALKEPSNSSVPPDLVMLDTTNSGLFSDLECLDFIPSRDNDTVHIFYMKHGQTSAVDILNNVTSYNSVQPQFVEFLHALGWPVDVRKHAGWTGHVSTSWKITEPDDMDEDEYQTGTGGSLYDGRQQVLYWADVLSEMAVVVPSPETYKMRTLNTTEQDKSPPMYRGGPYTSSPDPQKPTTLLLEAERGRASEKDSPGSPPEPQTSGSGVKYRRLGRQPALMTGPDTKVLVVWLENFEDHDNFPIADLLVVTGTGQDQSTTSSSTSMPRAQEKDVYVIFIHALQNGLFRIQMMEYEKTQTKMSVAIPLVDGMVVSRRTLGSMVRQTAINICRRRRLESELYQPPHVRRKLKIQEMVNKYKCTMSPAEFYTALFQEVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACB2</accession>
    <name>A0ABM1ACB2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101860455</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101860455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944985.1">
        <property type="nucleotide sequence ID" value="XM_013089531.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860455"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022728">
        <property type="entry name" value="Period_circadian-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050760">
        <property type="entry name" value="Period_circadian_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269:SF16">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12114">
        <property type="entry name" value="Period_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="306"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="640"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="847"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="894"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1359"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1504"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1120"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1164"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1364"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1393"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1411"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1530"/>
            <end position="1543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012944985.1"/>
        </source>
    </evidence>
    <sequence length="1610" mass="176266" checksum="02A9AED808058072" modified="2025-10-08" version="1">MEQQLSEKRKKTKQNKSNTINDSSYGSMITGTSSSSSLSLSLFSESDLAEAPSTSGCSSEMASAMQSKEKKKERAKEFMKKLKSMLPMKERTGKMDTLSTLEQLVNSMRQLNEEQKRGSEFKTPPPHNGSYQGNDALKLHKSDMHMTVSMKNHVILATSDSLMEHLGYPVDWWRGRLLRDFIHKRDINTVNGCIAMYSMDEPTDTSDTVTSSHSANPKESSKYFYARIRRFRKLGAGFNIQNVVSFCPFMMMITYKEMQESEEEAGVPKKGMMLYCHPLVSAYEVGKPLPDQRTFSLRHSLHCNYTYVHPNAVRLLGFLPQDFNGMSIFDLYHPDDYQQLLDIHKKILLSMGQPFKSGGMRLKTRNGCYVEVETEWSSFINPWSMRLEFIIGQHKVITGPSRPDLFEDLQNKQEKFELSPDLKKVQEKILEVLKKPIQGVFTEPAPVAAKIVKDQSAPGPMVAPAQTQASRETEAGGAKGTAEKSKGNETAVAESKSTVIDDKGISSIYNQLNYSHNIKRFLMSHPKSFSNLSDEDSVMTRDDSEDEAINDEEEMPLEIPVVKPPSCGSSTQVHVSEQGHGEEMLSPPTFGDEAMPPREAPADNIHFLTEETLKKHTKIQERLYLQRISEEQPMLLNMRRIKSSRNTSHQKRPRPREAGEEMDTAKHPCTKSGVFRSSSNIFMQSFPTVTSTDITPSTSTANPIFGQAEIVGRPPFDSTFLSQSAPLGFQPFPAGYHQTGNQPAGIAIPAQPIQLMPRASLPLSCLPPTLAPMIPNHPGLLDSSRAGPDQNIQWPYYPQTGYTLLPQVMAGFYRPLLQPVQVQAMTPQPGAFMKAGNAVKLVTDQVPVKDTQGEQPAKKSKMDPAKNSELDNPSSSVEDTASSILYLLDADSSTFEDSDNRTGPGAAAAAMPRMQNKRSNEPPWLRGVKWNNDVKMRYTLPQRKLYTVLKMDDKMLKKASQGDLVQASLEQLMEDISMPDHENAIDEEADYQFYPGDEPLDELDMLSDAKIQEAVITGPCMDMNEEEGAVGGGGDDGGGGGGGGRHEDVLWSLGTCEHDEDNYDTPVNSHSEDEKAPPTPTQADANAGKTEGKRDESPNSSSGSSKATEGGEMVSMETVFMSNSQSASGGSLAKRGGSPKDCSLSGDEGSSGSDGGQKGEMEDSQSNCSKVSSDMTPSDDRSNEEAGSSLKESDASMKHLKDVSSVASSNSSNETPEIGEAGGAAPVRDIEEIFKKLFVPLKVRVREKLNMPKEPYWLVEAHLSQRVAMTYKLPSLQLEDVLSEDKKKMSDLVQSATVKQQLLQLLNEVDIKSASVVGTSLSFSSPVASSSSSYQNHPVMSFTVTEPTTSVAMETVPAARESLSAGSSPPSKETTTPLHSMEDKVAGAEHVGSPSSGLGLGLESVKEEEEEKKLGKDCASKMESSCDQGKVEAEKKLSSLLSQDGTAMSVSNESLKALSVEMGSAEPSIAKSSLCEETAHLTLAKSSSFLSLDSMSNSPQAPIYHTTRLVKGRRHATSSDTNTDPIADESQFNSSAQSRSSSSIGVPVHRPSRAGHSQARTDAYLKEYLQAMETSSVSGQNLEDVIMNKIFVPKDSSEVKDMMNDFHSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADA8</accession>
    <name>A0ABM1ADA8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013680</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945501.1">
        <property type="nucleotide sequence ID" value="XM_013090047.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013680"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945501.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44919" checksum="637869CFB0E7FA13" modified="2025-10-08" version="1">MADTEDILSVHDPYLDEDEILAGSESVPEPSTSRGSEQKRITFPYSAQSDTDIIQDVLQRNTEAVAALVRSMSAKKKRTRKRSVSSSSCESPILKHKKKRYYKSSEKRTRRVSETTQASHSNLEETGNVLSDGEIIDDLFCPPDNDYRGERDEGALGAAGDWFAEANNEYEVDEEITDPLSENLAKFVEKRFCTTMKDDKMKEKVSKYKRPGNCEALLVRQTNPEIWKLLQSGGKKNDAKYTSIQKTIAKATTAVAQCADLLVKDGESKRPIVQKLLDVISILGHSQQKITSRRKEAQRWALPMNMKGICDVPIDGTKFLYGDDIKKTIHDANEQRKMVQFSSPRATHANAYTSAYGKPAQRDRKRHFLAYQAGRPSGQRGRGYAHRPSASHAAVANKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADU7</accession>
    <name>A0ABM1ADU7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC106013757</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC106013757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945793.1">
        <property type="nucleotide sequence ID" value="XM_013090339.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013757"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_012945793.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37560" checksum="D261E0FA05C4DFE4" modified="2025-10-08" version="1">MASAYLGPETHRPLSVISESFQSRYRIPNYVGSEQFRFGEEYEEKMYSLLHEHLELGTTDRMVYVGDLRGSLSKAIQDRFCLVPPVQTVIPGHFHYAETDDGYKMLPIRIAHVGAEDFFRKLAEDPSPSKPKYDKILVKDCVRYLAEPRTTYANMVASLAPGGKMLLIHRPGQLSTLPYFSDARQRLSENDIPYEDIIRELQACKLDVSWELECLPVRMQKTKWLAMVKEKFPTQMEILSGREVKSGIRELAEGVLKYEGDMVEFMDRLLFITATPSRLPANRLTVQRSGAELMATPQETNLKYIMEMCPDELSELRRTSLTDDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE10</accession>
    <name>A0ABM1AE10_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106013790</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106013790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945895.1">
        <property type="nucleotide sequence ID" value="XM_013090441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106013790"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058265">
        <property type="entry name" value="DUF7959"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25899">
        <property type="entry name" value="DUF7959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7959" evidence="1">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012945895.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13308" checksum="4DB2D6B3203CBE41" modified="2025-10-08" version="1">TYRPKILADVTAFKGGILSAITKATGISKLRVSSIKINFENVIRVRAVLLDKAPISGDVKSVKQQVDLKTAGDALMDAIRRGQFTVSLKEAGNAVSSYGVPVIASSVREQEYIVKAPEKGYGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEA1</accession>
    <name>A0ABM1AEA1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">E2K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101864355</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012946027.1">
        <property type="nucleotide sequence ID" value="XM_013090573.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864355"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="83"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="162"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012946027.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="50944" checksum="3794B3609D26A27F" modified="2025-10-08" version="1">MLASSRLRHISQFRRLASYRPEALQKKSLACLAACKVQGTEATASHAAVRTPITFRHEVSQSGVPCYHSRSFHTSRHLRGDEIRTVPCPNFPESVAEGDIQWDKAVGDAVEADEEVGQIETDKVNMPVQAPVAGVIEELLVESGATVTAGVNLFKLRVGAGGGAAPKPAAAAAAPPPQAEAPPAAAAAAAAPPPPPPSSSAGAIPDVAPPPARVPELPTSSTPTSAVKPKAAPSGGGVAPTHLGGSRSEQRVKMNRMRQRIAQRLKDAQNSCAMLTTFNEIDMSNIMEMRSKYKDAFLKKYNLKLGFMSAFVKATAFALQDQPVVNAVIDDLEIVYRDYVDISVAVATPKGLVVPVIRNVEAMNYADIEKTIAELGERAREGSLAIEDMDGGTFTISNGGVFGSMFGTPIINPPQSAILGMHGIFERPVAINGKVEVRPMMYVALTYDHKLIDGREAVTFLRKIKSAVEDPRTILLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFQ2</accession>
    <name>A0ABM1AFQ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane emp24 domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101855621</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946751.1">
        <property type="nucleotide sequence ID" value="XM_013091297.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101855621"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047512575" evidence="10">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012946751.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23592" checksum="60830B395F52D1C3" modified="2025-10-08" version="1">MNLILFSPLALLLAFCGISRAYFISIDAHAEECFHDKVTSGTKMSLMFEVAEGGFLDIDIKIYGPDEKIIHSGDRESNGKYTFAAHMDGNYKYCFSNAMSTMTPKVVVFSIDVGEKPIAMEKSKDGTEEGDANHNQLTKMINELSSGLTGIKREQEYMEVRERIHRSINDNTNSRVVLWSFFEALVLVAMTLGQVYYLKRFFEVRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VP58</accession>
    <name>A0ABM1VP58_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ecdysone receptor isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101846778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824200.1">
        <property type="nucleotide sequence ID" value="XM_035968307.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846778"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="67"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="396"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035824200.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="70605" checksum="C44CA28095FB3C04" modified="2025-10-08" version="1">MCASPTMMADETSGDSFPLSWIQKFYSHTPHSYISMWRKTHTTVPGRTSGPSKREQKRRPKPKDGTVLFCGVCGDRALGYNFDAISCESCKAFFRRNALKTKPFTCSFEGNCKLDPHTRKFCSGCRLKKCFNIGMKRDWILNEDQLVKRRQRQHLRQQTSSLGEVSPPNVQPCSSTSGDPLNDDLSLTFTGISPDHESPSEQRLTRSHSGRHLPAPLLHHPHHHLRHQQHQQQPQQHGHCTDSNSEFSSPSSATLYSEPSSSTSSVSPSPLGFKRQYSHSFSSPSSPSSTTPYQSPRSAFLPQHSHAPQNFLPSTPADSQRKIPKVEYVSEDEDCMLYNKPQRRQSDSGPLYQMPMSNDAQTSASVCDVVVKTEDLSSAEDLRVPLNPYINERLMSLKKTYDDIFEAAYTQDQAPKLQKKPHSADQLYNMTDVFIRRLIRFAKHIPEFKSLSQADQIHLLKGGVMEMFVLRSAMGFDAKSNAWKFKVQQGNIDQGEGKLDSGVINNTLGSSMFMQHMMFVRQIQEITKSDRIILMLLFIIQLMSPDRPNLGDKRSVSQSQERHSMWLKAYLESQHSVEEAGQLYPLLLLKLQDVRSLGAESCQLAAHLDINNLEPLLVEVFDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPL2</accession>
    <name>A0ABM1VPL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862400</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824354.1">
        <property type="nucleotide sequence ID" value="XM_035968461.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862400"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="168"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035824354.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34416" checksum="CA69274C094A0529" modified="2025-10-08" version="1">MKLHKVEKTELPVLLEWLKGHLPDSFKLYSNLKFLLRGWLEGWTFYALVDPDWPHIMAAGEGLAESDKYEFCAFFTDPHATCVFSPNNQHVRTLLTWPGFLDWTQPIIFHGVHSDNADVVEEVSQQNGGGTRDHCYAFDVRPEDLVSLPGTPAGATAPEERWPVPEDLTLRQLDPDTDTARAVEVWHRKRRHATQFVNRILKHVPSLGLFTKGGRLVAMEYGTHWGTMGTLHVDDDYRGRGLAKILTCRLAHKFYEEGLPAIVNIISTNAVSKTLHTKLGFRPFAKLDWYMHGDIAEYKKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPQ9</accession>
    <name>A0ABM1VPQ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protocadherin Fat 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC106011160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824401.1">
        <property type="nucleotide sequence ID" value="XM_035968508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011160"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="69"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="174"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035824401.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="28240" checksum="FC2B259268C9BB10" modified="2025-10-08" version="1">MVRYSLLDNGSDLFSVDSRTGLVLTKAVLDHETRASVTLTVKAVVGGRSSTVKVDVNILDVNDEGPMFSPANYKFTVLEDTPVGSFIGQVNAIDKDSGSNGVVKYTLLDTGSSHQFSVESITGQISTMAALDREVQGSVTLTVSAADLGSNSRSATAVVNIDIVDVNDNAPMFTAVKYMFQVSDPAPVGFIIGTVSAIDGDMGDNGMVTYSLRNGTDQFDINAHTGQITLVSALTSADVTFIVRATDNGDPALSSDAQVLVKSSDAVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VRD6</accession>
    <name>A0ABM1VRD6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">E3 ubiquitin-protein ligase XIAP isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101852760</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936515.1">
        <property type="nucleotide sequence ID" value="XM_013081061.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824978.1">
        <property type="nucleotide sequence ID" value="XM_035969085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852760"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16510">
        <property type="entry name" value="RING-HC_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012936515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035824978.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45499" checksum="1944ECA693DCF8A5" modified="2025-10-08" version="1">MDKQCLQSIQRLLKAISGKPKREQKGTKRYHNVGTLSELNVQEHDAVGDHQTLNVPSTNSRDIPWRSLSSEKLRLQTFCKYPSGAHKSAILLAKDGFVYVGTGTTSDDSVLCYFCAVNYSGWLATDNIHNVHTRLSPNCPMITLVDCHNAPIPVPQNWHYLIAKLLSQNDKSVSSESPKGSGNTEEIEFEVSIEVGLPESKRRHVIVCDSHGQYQNTEAQAPDRFPGPTQTASTSWTDLVPPQSQSDVVAQSPGERIEASAVAREDPLERDVAVQAVTEMGFQKHYALYAAKDLRDEGASLFDVKLFERLCEMQKRRGELMELDPDERVNIDEHSVSGDAETINNLREENFLLRQRTVCKICKDKEVCFVFLPCGHLVSCAECARTTETCPVCRQDVLDCVQANYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VSG5</accession>
    <name>A0ABM1VSG5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 74B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825357.1">
        <property type="nucleotide sequence ID" value="XM_035969464.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862498"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="510"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035825357.1"/>
        </source>
    </evidence>
    <sequence length="604" mass="66635" checksum="93C815C184B8FB0B" modified="2025-10-08" version="1">MEKERLSIKMQRHLRPLTAAPKKSRPSASKSGDSRPVTASVARGRGDVNGHKKAIARHSLQKSHLHATGRSSESDFASQVDSPFDLTPIEDVPEDSELIDIVEENNKTEIDCAVALESAELTPLSTESARNRHPSFETWLSGSPHSSEEFDTDVEDELSETPMSTQLDATGRLEYEEQCRRHGFIPVSYLCRHIGERNVRMRHRYLGGTATKPLALAFKHNTVTENLDLGDNYIESSGTCYIANMLKENHFITSLTLSNNVIGSLGAEAIAEMLEVNTTLKMLSLAGNQLSDTDAYHFINPLKNNMSLMSFDLSHNEFSVMGGIHLGGALSVNEGIVDLDLSWNCLRKQGAAAIVNCLRYNVTLEVLDLSWNGFGLEGAMALQKALPVNTTLKVLDLTNNRMDTKAAQKLALGLKKNTGLETLILSMNPLGDQGIEQILKALAIHPNLHFLGIENCAELGVTKANATLIQQLETERGIVILHGGAGGFNRTSEEKSVTNVMRLFNTFLKKKKGELREHFKQYDKDKTGVLQVDDVKICLRSAGLNLTNRFLNLLVEDMDSSHSGEINYKDILSGAAFSEHSRRRPSRGFQLLSKTKLEPDSDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW13</accession>
    <name>A0ABM1VW13_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein heavy chain 1, axonemal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118477947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826605.1">
        <property type="nucleotide sequence ID" value="XM_035970712.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477947"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035826605.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45985" checksum="4B258ACA73FD838A" modified="2025-10-08" version="1">MAYYEGGKRSRYFAADKKRSVLLKKLRSKDKIYPSIQRRGYYSDLITTEANLGEFEDLQVGPSTAQPTLWNVKTEKHVPRADALQYASEDVNKQLQKQVYGPDTGVFVKKRKSGESCASGVDFPTSAFEPKVQLPTNHKPGERPRKIELERLRRLFARLDLPLLLKERGVKTELLMPKQHKNLNIILMMDPSDPAPFPPYLPLHIFDNIEFDCRTPKDWMKLGDMTMARHPIPSLCLLPVKDEDGDKDPTDPSIEYDWFDAGVLDYCHNTNLYFVQRVDENCRIVNPDGETVINGSIDPVTGKRIIHRNQFWIERWRVMFRAEDPRIFADRVAFAYQARRRCEAELRYTLYIDCMPMDGLGDLSPENFASIERRAHSTPGLAKYKKYETRFYFSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW59</accession>
    <name>A0ABM1VW59_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransferase 1A2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101848300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826651.1">
        <property type="nucleotide sequence ID" value="XM_035970758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848300"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035826651.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25112" checksum="0A77C66204A2A093" modified="2025-10-08" version="1">MNTKVDEKLQAIVGPRRIITSHLPPKFLPEDIFRKQVKLVYIMRNSKDTLVSWYDMASKYEQDTVRFQGTWEEFLELQLAGEYLWGSWFEHVLAWEKFMSDNPEVPVFVAQYEKLKEQPADVIRDLCRFLGQPDTLAEQIATATSFDNMKAGTQKKSKDVFETFFREHVGIAGKGLVKSWKTKFTVDQSERFNRAFEEKMARSELGNSLRKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWU0</accession>
    <name>A0ABM1VWU0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Complex I assembly factor TIMMDC1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translocase of inner mitochondrial membrane domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11 12 13" type="primary">LOC101851967</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826879.1">
        <property type="nucleotide sequence ID" value="XM_035970986.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826880.1">
        <property type="nucleotide sequence ID" value="XM_035970987.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826881.1">
        <property type="nucleotide sequence ID" value="XM_035970988.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826882.1">
        <property type="nucleotide sequence ID" value="XM_035970989.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851967"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055299">
        <property type="entry name" value="TIMMDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13002">
        <property type="entry name" value="C3ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13002:SF1">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR TIMMDC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035826879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035826880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035826881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035826882.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37586" checksum="528E52ED644ABEF6" modified="2025-10-08" version="1">MEKSILPKMAFELPVPSSPISKPADVRMSQINVLTQNLQSYPLQVRRLVLMQPSMRQLTPLLGSDVLPQCRTYLPKSAWKRNPFHQLFPVAQCSSDSRNSKSSSELTVSSGDDDQLPGVSARRSVTSTSSSTRQDDISGVQINMWLDQETGLDRLRQAYTIGSSGIFVQEDTRNLNTMLYRTALLGFFISVVISSQNETRKKQKHLSQTEALLKGVQSERQLPRQILKDAAKTTLKLTAWAAVLFHLPHAIAVYRNKTSIWEYAATSVLAFGVLGVSKSPRVFLSFVAAGAVTGTVGGYLICQVLTSAGLTQEQRHVERVKQYILDQRSMKAGIDDVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VWX8</accession>
    <name>A0ABM1VWX8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC101856747</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035826919.1">
        <property type="nucleotide sequence ID" value="XM_035971026.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826920.1">
        <property type="nucleotide sequence ID" value="XM_035971027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856747"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045023434" description="Glucosidase II subunit alpha" evidence="12">
        <location>
            <begin position="21"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="14">
        <location>
            <begin position="79"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="13">
        <location>
            <begin position="382"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="15">
        <location>
            <begin position="718"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035826919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035826920.1"/>
        </source>
    </evidence>
    <sequence length="940" mass="107682" checksum="74001713B4F86F9A" modified="2025-10-08" version="1">MKHLCLMLGVLLCTCLGVHRENFRTCSQSGFCKRQRNMEPGTSSYVVQPSTLRISSSSLMVEVLNTKNNIRFLLQGYGLQHGIFRVKLAEAEALRERYEIPVGLTLVAEPVQEELKYHGEKDGKLTFSLGQNKMVINVNPLRLDFLINDEPVTSLNAQGLLKFEHSRTKEGWFSSLGSSVFSLLSQPFREAKDEGAGEESEGEQKEEGEEVKAEEEEEPDMWEETFKGFTDSKPNGPVSVGLDIAFPGFRYVYGIPEHADTFALKTTKNTDPYRLYNLDVFEYELNSPMALYGHIPFMAAHNEKNTVGVFFQNAAEGWVDIHSNVADKSVFSNLADFVTGNNEVPQTDTHWFFEDGIIDIFVLLGPGPRDIFKQYASLTGNTPLPPLWSLAYHQCRWNYNDQDDVRNVDQTMDKFDIPFDVIWLDIEHTDSKKYFTWDGSRFSNSIEMLRNLSSKGRRMVTIVDPHLKREDGYRVYSDARDKGLLVKNKDGNDFDGWCWPGSSSWPDFMEKHVRDWWADQFALDKYVGTADNLFVWNDMNEPSVFNAPEITFPKDVKHLSGRENREVHNLFGKLVHDATFDGLLKRSNYQERPFVLTRAFFAGSQRTSAVWTGDNMGEWSHLKMTVPMMLSLNLAGIHFSGADVGGFFKNPDNELLTRWYQAGVFQPFFRAHAHIDTKRREPYLLPEAYMVVAREAIKKRYTYLPFWYQLFHESETTGMPVMRAIWMEYPKETNVFAMDDEYLLGDAILVKPVVDQGQTDIAVYFPGENTVWYDIDTYKTYPGRQEANVEAPLSKLPAFQRGGSIVPRKMRGRRAASLMYNDPFTLIVCLDKQGKAGGQLYFDDYHSYGYRNGQYALTELSFHNFKLENSVKFKGEGFTTKEWLERVVVAGVNTEPKKIHLVKPDGTKMELGHTYDAQSKVLTIRKPGVNVAEKWIINLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VX01</accession>
    <name>A0ABM1VX01_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118478104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118478104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826943.1">
        <property type="nucleotide sequence ID" value="XM_035971050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478104"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035826943.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15131" checksum="4CC57B0047F3CE69" modified="2025-10-08" version="1">MAAQASADQEVEVKDEVLLTWVGEIKVLYRDVPPLMCSLTDDMKSMKVLEFVRFLRSHQHFTTVVGDLSEQDTALFLFCPGNGVEAMHRNSRLGNYSDSFTKANYVAISHKDLINERQADAITNINLKEQHAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZ85</accession>
    <name>A0ABM1VZ85_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 71 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101850833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827728.1">
        <property type="nucleotide sequence ID" value="XM_035971835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850833"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053040">
        <property type="entry name" value="LRR-containing_protein_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827728.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="65285" checksum="0DFE44010F55F54D" modified="2025-10-08" version="1">MDRQDTLWNKSNVIQKVRMGKKVEKALSKDKNPSSATHVEDDNPNKTPEPYKCIGNFLTDFNELCKQNGMAVIPPVVTRPKPPGPASGGNEGKPDKKGDKNKQPVPEPEPEVELNEDGEPIEPPPKTYSTRDKFEYFKPSVQVELDNNDKWDSVSEIFIRGWKIDTPMMDNFQQSWPTLERLHTINLWYTGLSEDTLHTLAVFLPQCTNIKNVLLDGNPVKEENWAELIGEESLVQNLSLRHCKITDKGSAGLGRALGTAKVANTKLLSLNLTGNDIGDPGAESLAGGLRMNRTLMSLTLTSNKVGDKGVAKISEALSRFPLSHEEVVERRKLISDRGSPERNKSPPPSRRAESKDRPGSVRSMTTQDKTKQKPSAKKKDVKGRDAKEETKTVKKDKEDTRGGGKRALWAQQTNPNAGTGRMSSGSVAFKAAIKLVTSASVAAEATKTMGKTKDKKKDKGKSSNQEAELAESPVSSPELEIVNMDSQDLINPLLEVADYMDGQLWIAGNRTLINLNLARNNISETGMSSLLKAIQYQTTLTSGNRSGGTGLMRLVINKNSVRPENEVMAKLSEKMMLKDPFYKPPITPEGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0K5</accession>
    <name>A0ABM1W0K5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Connector enhancer of kinase suppressor of ras 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101864258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNKSR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828198.1">
        <property type="nucleotide sequence ID" value="XM_035972305.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864258"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06748">
        <property type="entry name" value="PDZ_CNK1_2_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09511">
        <property type="entry name" value="SAM_CNK1_2_3-suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049628">
        <property type="entry name" value="CNK1-3_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017874">
        <property type="entry name" value="CRIC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10534">
        <property type="entry name" value="CRIC_ras_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51290">
        <property type="entry name" value="CRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="CRIC" evidence="7">
        <location>
            <begin position="85"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="224"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="763"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="585"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="882"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035828198.1"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118428" checksum="FF1423714D4395F8" modified="2025-10-08" version="1">MAYFALIQFEHWNEDDVASWLKGLDDAIQPYIENFVKTNVDGRKLLMLTHSDLDKLGITKLGHQELVMEGVDLLRSLRYTFETENLQHLALQLGCKARSLHNEILARNGENDPNRANIQPSRHHHRRQLSISVLSSVCDIMLTLKTLTSWLDKAPFETIHGISLLRNSIVKLGLELVTVAQKESGTAEVEQAIVKTCQGMAEYCDGLVLNKKESLVVQPASLEIATIRKKQEDELGMNIQSSYYGIHVIGCIKDRSPADLCSKIEKGDEVLQVNNQTVLGWQLAKLVAALKERPKEVTMLLKKRPRHTNPFGNLPNRRQMNRHVTSVATLPKIMKRRSRDGEKPARPTLEYVTSSVPTGDIYITKESPEDNIDANDDTDNDVFRSGSESPQYTLPVIVDAKQRRATVSGGSPTFERPSLVVEDLDPAPLRPKSQAINAVEREAAIAALLAADNSLYKKTGDERVTLCTRKLGTREVRLRYKKRERGQVMTDNSLYKKTGDERGEVMMDNSLYKKTGDEREKKRSLSEPEDVSGEKISATFRALDTPNGSLSQPQTTSSVEKTGKSEPLLKDTINNNVSVTPTVKFEIGGESESRSNSTGDVVEEDAGEAQESLDEVPKVQEFFVTKPTAVLREGSLSARKSWNRNQRIISMEIAGDSGKGDFPQLMRIRRLDSQQIAELENKMDDDDVFVKPQKKVDFDVSPKESEKAETFTHVVVGGVVQKVPVEKAKPYTTPESPTVRLRNKPSGSKTRLDRRVSCKDLGKGDCEGWLYKRKHKDRALSKHWVKRWCVLKTFNLFYYKLKDVSMCGFKKGRENTLTPLNLSLSHSTNLKTKKLEYSAFKIHNSGTVFHFASERQDDMGKWMNKMGLASIYYDASKDKTTSGFARPEKPSVSSAQSGKTDAYYSESDDDGDDVSDRLYGSNQSLNSVTSARSQAPSQVSPLTMRPHLRDLRDNVGASTEELRVMFNNIQSEDLTIDGKDRIRQRRSQCTAPSNLGAGANAAEVERLRKLHSLQRTLRAKEKELLDIEKLVNNPVSPQDLQQFAESHLEVENSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0K8</accession>
    <name>A0ABM1W0K8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101847609</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101847609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828201.1">
        <property type="nucleotide sequence ID" value="XM_035972308.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847609"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1170"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1198"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1226"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1254"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1282"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1310"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="577"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="726"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="935"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1084"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="627"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="952"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1096"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1125"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035828201.1"/>
        </source>
    </evidence>
    <sequence length="1393" mass="151229" checksum="C2E6A398BAA59FEF" modified="2025-10-08" version="1">MDTVNPEQDFDVDRRDTGFTKLDISLTGSSKSEKILSVEAEEDCVDLLPGTGGTAACSQETPSPSSRGQNCSQNSNYCPNSEEVSPSRVEEHVVVSVPGDSCRISSDSGDGVSLLPCAQTNAPSVAKNRKMKNSKDEVTGSGYDADVTSCASASVMVRTSRGKKQRRSGGTAVGTGADGGGVKGRKQRLSDGAGTRQKNGRLSDSEVCTRHEQPPRERKKKSGCAGTVGVCGWPSVGQVADESESFNRPVRKLGQGSGTRRKCRDKGKDQTLRKEKRKKSRTLKSAEEFVDEDGECFRLSPHGKCSSSPAAGGQATEKPHQCEFCGARFSQRGNLKSHTRVHTGERPFICKFCGKTFADQTNKKNHERSHVGDKRYICDFCGRRFITNGVLKKHLRKHTGEKPYRCDVCGKTFAQSDYLSVHRSIHKGDKPFECDLCGVKFTRNCSLLRHKKIHKGEKPFQCDICQAKFSRRSNMNTHRKSHLRGKPAEKEVVEGASSAWESQGTGSVTGSAWLKDPMYYLWQRVSGQGPQAQLSQVERAPEVVTSTPSAGPHLLGNNTRSAVSHTAVSNTLTALSQTPLHNTHPPVSQTPVHNTHPSVSHTPVHNTHPSVSHPPVSHTPVHNTHPSVSHTPVNNTHPPVSHTPVNNTHPPVSHTPVNNTHPPVSHTPVNNTQHTSHLPPVSSPPPTLSPPALNSPHRATCDVSHAPNITHNSPLLSSACGALDYTRPPPDPRGASGLVGNMAGLLPPTDATSHIPWPCHAPTRAPSSETRQVHSIETRQVHSTETRQVHSTEDSAFLTAHSSGTEVTTQSPAPHVCSTEFYRVTVRDDSDLPSQPSKTHVSYDLTANVSSSEVCHVNNVEDSAFLTRVPSSHVSLTLPSTHMSLTGHTQVPGTEACPVDTRAESSLPAHPPGTHVSHRAHVSNRQVCHRDAIGNLPDCPTRGPNTLHETHTLPTHVSSSEPTQGVSGFPLPADFLRGDTLSSQSRDLGVPSKTCAWKGVPSETCAWERQTADGTSDPPTELCPGPTEMSSRVGEEQYASSDVRLFHHKEYCGRSNVALRDPKEQRVGSGVRSLRHQGHHANLLHKFASPDGGGGGDDEGGGDDEGGGCASGGGLGAKSPDRTRMSAQGDDTTTTDVPQGRTPAVGQSGFPCPAEENPPKPAKVKWERAYQCEFCGRRFSQKCNLSTHRRIHTGEKPYRCLDCNLRFSDYSNLAHHVLIHSGERQFVCHACGVKFVEKSALKKHVRIHTGEKPYHCAMCGKDFARSTSLSQHMLIHGTEKLYTCDVCGAKFAQSSSARRHKKTHTGERPFQCDVCLARFSRRNNLNIHKRRVHPCHVVSLVCDLCGQVMKSDLHLREHRAACQQKDTYSKLMWAKQTSMQITPSGGGTFAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1Q3</accession>
    <name>A0ABM1W1Q3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Receptor-transporting protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828596.1">
        <property type="nucleotide sequence ID" value="XM_035972703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850444"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026096">
        <property type="entry name" value="R-trans_p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14402:SF10">
        <property type="entry name" value="3CXXC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14402">
        <property type="entry name" value="RECEPTOR TRANSPORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="8">
        <location>
            <begin position="81"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035828596.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23352" checksum="E37EC5148EAFAB4B" modified="2025-10-08" version="1">MIMTNTLPAVPISPVSPTLSLSPIDLSKCSESELGLFLSQRMELVWHGEFDRLFAQYFPHAWYLVPTFCPPTDRWRVFKDSAKVRFSCQECGHGWTSMKGRVIFWFHLNYSTNSGYVMFKLYGQQCQKCKNGNYEHAMWYPEEVVKVIGNVYNRVGQIFYGFVRPPLRIDRRQGKPRNQHNAELCQACKEGLCKEEWSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2V5</accession>
    <name>A0ABM1W2V5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">BTB/POZ domain-containing protein 17 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC101850302</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828993.1">
        <property type="nucleotide sequence ID" value="XM_035973100.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828994.1">
        <property type="nucleotide sequence ID" value="XM_035973101.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828996.1">
        <property type="nucleotide sequence ID" value="XM_035973103.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828998.1">
        <property type="nucleotide sequence ID" value="XM_035973105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850302"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18493">
        <property type="entry name" value="BACK_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18292">
        <property type="entry name" value="BTB_POZ_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF41">
        <property type="entry name" value="HL07962P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035828994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035828996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035828998.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="56717" checksum="A1E8185232CD7CAD" modified="2025-10-08" version="1">MDYTMPNYRPAVRPTSARGGPPPRGAAANQELALRRQGGSAVVPLTPPTPRAMHTQAQSGSSSDTEAVLSGRPETMEPGDPGETTPETQVTGTQPRILRDESNFIQNVGQFYNQQDISDVILKIGEEKYYGHKFVLAKSSEVFRTMLYNKNWTQAGLPEIVLEETEECQKYFDTFLRFLYTAEVNISVDSAVGILCLADKYSVESLKNLCTQYMVEHTRSPLVKNALNWYSWSKALHMEELIQQCSRTIAWNAEHLLNSPEWLHMDLEFVSDMLQNRDLVISSEHSLFQALELWLTHEAHVENYVEHAKTLLPLIRFPQMQVPQLYNVENSEVYKNQELQPLLDRLINKAYRFRSLCPQQADIDVSFTEDFYLPRNYIDLSVDTVRMQNTLRFGIQVDVRTYVGPVPSLARDGEWKISYRKTNDTWTLQVYCHESALVNGEARVQAALIISNQDDRVVQLEESEITTCSRGNHLTMSVAVPNQDSCKSMSVLIKPVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W395</accession>
    <name>A0ABM1W395_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 23 member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101863068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829138.1">
        <property type="nucleotide sequence ID" value="XM_035973245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863068"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035829138.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="49528" checksum="A5F74025434E6EBC" modified="2025-10-08" version="1">MNSHTVKIDTTVVNELTKFGSEKDAEDGRLCLDHKKNGNIDDIEMEIDIDSQKPLVYRVDETPPFHLLVLFAFQQTLLAVETTIVVSALVAEVACASHDFNVKAQIMSATMIMVGVSTFLMSTIGVRLPILQGPTMLISMMVGWALSAILTSAGYFSDDPEAIDYLARTDSRLYVIDDAPWFTFPYPGRFTPLSFHAGTFVNFLLATLLSIMDSVGDYNATARVARVPPPPPYAFNRGIAVEGFTSIISGAMGCGHATVSWGSPIGVMGITRVVSRRVFQAVGCLWVLLACVGKLGATFTTMPFPVLGGVQMVSVGIFVGVILSYLQTIDLKSPRNLAIIGIALLLGLILPAWLKTRPDGINTGNEEADNILKMLLANPSFIGLAFALTMDNLIPGTLKERGLVPYSKTSMSQPGKGNKDTYEGGIETYRLPFIPARFRRSRLLKLIPLFDYEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3Z7</accession>
    <name>A0ABM1W3Z7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101859992</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829390.1">
        <property type="nucleotide sequence ID" value="XM_035973497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859992"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035829390.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52941" checksum="4DE300E631A899F9" modified="2025-10-08" version="1">MAEERLTAKQTINNSTYVYNTLFSPHQDFVYGFQRWNVSFVRSDRHIGAFLKLQTPSQGLRCRLDFSFTVVNRDHFTKNVSFIEKSCEFSPETNVFGRKTFIEIDDLIKRNFLHESGDLLVEVEMRNIHSIYECFMRLPKEGGGSGGSRHGYGDRMESTYFMFGLSDWSISLFPDNSVAEADGSVEVQLQRHTSFDHLCYVRYRIILGDEGTFDSGDLEQVLDASGVGEPFTIGASVHRLSRGRSTLRVKVEMISVVSVSEVYLNAFSRSNNQSRAHFYDRDKQAWMVEADSTGKYLAFRLFYTDISHVPRKFSRYVGWNFRIISKATNARAKRALDGPFSRYYVQQEADDGCVIRTDVTLEELKEPECPYMDTDDRKLTLHIEWLDSHLLINPNYTNLDDVGRLHKHQMSREILALQAENYALEKQLYSYQQSLAKTSAKDGPSSRNTSRANSYDAGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4U1</accession>
    <name>A0ABM1W4U1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="13">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC101849272</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="13"/>
    <dbReference type="RefSeq" id="XP_035829684.1">
        <property type="nucleotide sequence ID" value="XM_035973791.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101849272"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF175">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="973"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1058"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1091"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1134"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="17">
        <location>
            <begin position="909"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1164"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035829684.1"/>
        </source>
    </evidence>
    <sequence length="1311" mass="148519" checksum="70054FB966CB0D11" modified="2025-10-08" version="1">MAVAAEGQAGSGSSYQRFGPRMITESLRKRFFTNNLPETNRVVYVDNQLLPGDDEVVMPLYPNNRVVSSKYTLLTFLPKNLFEQFRRIANFYFLCVGVIQFMIDTPVTPLTSVLPLVFVISVTAIKQGYEDWLRHVADNEVNLRPATVIRNGKAQTDCRAMDIKVGDIVKVYQNEEFPCDLVLLSSADPQGLCYVTTANLDGETNLKTLFCLSDTRRFRSPEELGELRARITGKPPLADLYTFEGVLEAISTENQAKPLGPENLLLRGARLKNTEHIFGCALYTGKETKMALNSKFKQTKFSQVERKMNTFLIVFLVILLVEIIVSTGLKYWYEDVHGDLDYVPEESNKGKPTKVLENALAFMVLYNYIIPISLYVTIELQKFLGSIFFGFDVKMYDESIDERALANTSDLNEELGQVEYLFTDKTGTLTENTMEFRHCCIGSRQFQDVDGTFCERVHPEMAPKKDITFTDEMNRFIRVLVLCHTVRVDRKQEANNGQNGASSIYSATGEEYDYQASSPDEKALVEACCRSVSAQTTYMTLLCCKYCKTFTKTKETFSIILFAYQDEMNRFIRVLVLCHTVRVDRKQEANNGQNGASSIYSATGEEYDYQASSPDEKALVEACCRYGVIYHGNNDEMMEVTFHKDMQRFKLLHTLPFDPTRKRMSVIIQDEKGEKTLLCKGAEVAILDRVAVGDVATTQRMIDEYARLGLRTLTIAQRTFTEAEYETLNESLVNAKRSLTRREELVSLLFRILSFFFLSFLQVWVLTGDKEETAVNISHSAGHFNSEMTEMRLTQVNSDEQCVEQIRHLLHLTSDAHTEVENPALVIDGQSLRFALQYSDQLFQLCSQCMAVLCCRMSPIQKAKVVALIKNSPDKPVTAAIGDGANDVSMIQEADVGLAIMGKEGRQAVRNSDYAFGKFRFLHRVLLFHGHLFYNRIAVLVQYFFYKNVAFVTSQLLYAIFSYFSQQSLFDPFYLLFYNLTFTSLPILIYGLFEQHKPQEDLLGKPHLYKTVTRNALLSWPEFLKWNALGLWHCLVFFFGYMFLIWDDVSIFSTGKIIGNFGFGSLVYFTCVTTVNLKLMLETNFWCLPMVLSYLFTFAGIIVLTSIYVNFWWPSWVTETHDIYKLLDQLYDTPTAWLAFLLFIVLALLPDFVLKILRDMRSGANEKEGSSSSTGGGDSSSKSVESRAPTPVVYSLSQETAGPGDDLKRKINEEQFELHQSRPQAIHRHAYDNPVAVDIMPQDANPLPSVEVMSGSPSHMFTTTAEINGIAGARRSPEVPAVAIMSGNNNVNNNITTVSEVKPVILESSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0J9X8</accession>
    <name>A0ABM0J9X8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-rich adhesin for platelets</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101848391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005088836.2">
        <property type="nucleotide sequence ID" value="XM_005088779.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848391"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF56">
        <property type="entry name" value="IRS-TYPE PTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="126"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1045"/>
        </location>
    </feature>
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        <location>
            <begin position="1069"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005088836.2"/>
        </source>
    </evidence>
    <sequence length="1282" mass="139437" checksum="7553846B5D12458D" modified="2025-10-08" version="1">MDDEDVIFQGDVFKLSESKKRLVGSKSDTWKPRYLIIRKKEDKPVLEYHRKKPKSSKKYEKTLTESFELWPTYKVEKLQDARGRSFVCEVTSPEFHLFLSGNTEKEVDIMVFLLQVQIRLKANITENLINVLPVDSDTLKKIGAKGKCSLHASPWGLTLVLKQTRALLAQWPLKSIRYYETSGSGTFNIEAGRVAPMGEGLFSFKTKPGEDDFIYDLIDNFIVDTLDRVKPTQKGTPEEIADYIREHDCLHSLTTVSVCSRRTPEIQNVLKAVWNIGSYSSEGSASLISGQSGRSGGRRESSGSSSNSNSLERGQAVVSSSSSSRLVINLERPELDRTSLASNRTVSSSGGGMREEPVSDRPPPLPARAPKHNGVPRRSRRRDHSLPRKADVMAKMATGATAEVPSLASMGEKLTDTQQVPASPRRHSNPSDSLHRVNHDDGLLTPPISHAQISPRYQNAPDQSHTQFHQLSGQQNMKVRVSKSPVVTRNPNKVGRAEYLINQPNSGLRSPTTGRSSETWTLDPSHLRENDRLDEQAYMDAVARASRQKYGGGHNSIDRRWAKLQREVSSDSQDVVSLSSRTGSVSSPSTPVPYRPSRTYVNIAVPEVSHERQRSADGVMGGGGGTNMLPPPVSPPLVIRHGRQRSADEFSRSSFGSIDPRNAAAFSQSTDMHHSRQNSVTSTSACSTLSRGRGDKKEGGAAPRISYTSQVSQASSKDGVAAPVVDWLMSASCEDLSDHMRTAIYDGETQSKEEDQGNTYEEIDTSKTEEVNRQEVTSPSLGSAVEDKPPLPFTGLKKFHDNTDSAYARDRSKSFGYVNIPSPSSPPTPHKPASTAPSAHLIRKMVNARAKQDTLRKSLSNPNFLNLGSKEHLYNLKSTATTSNNGNKLAVGSKQKSRSIGSLFPAIKKAFSRESLGHSRSTTPERRASFSHKRRSSEGESSSFQRQNSCHSLGEITIKGIRLTERSRSFRRVRGAKSVEVLARTNDGERSEDNRHSTGTSVSVHSAVSQSSRDTHLSAPGDVRSSSADTSGSGTSAQTAAPSTPEGSTISPPVSPRKSSSSRKKPSSGASNPGYMSTTYISLTSSDLPPLPSVDKSKVTPSSATTTTPSRTSSSSSSQSPSLSITTSSTGSKSPSVLTRTPSHTPEHDQIDENSNKCNNKGKVNQSNHHQHDGDSPSEPNCLPMQSGASPDKSNSPKKKRPHVSDLVAKIEGCKGDTDPSLSTSCNQVSNVSYQSSSSLSSSSSSSSATVKPFQPMPFKKHESKSRPFFRSMKSNNSESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0J9Z6</accession>
    <name>A0ABM0J9Z6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab9 effector protein with kelch motifs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC101854761</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Rab9 effector required for endosome to trans-Golgi network (TGN) transport.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005088865.1">
        <property type="nucleotide sequence ID" value="XM_005088808.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005088866.1">
        <property type="nucleotide sequence ID" value="XM_005088809.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005088867.1">
        <property type="nucleotide sequence ID" value="XM_005088810.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854761"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052124">
        <property type="entry name" value="Rab9_kelch_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647:SF1">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005088865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005088866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005088867.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="45718" checksum="4321916769941A52" modified="2025-10-08" version="1">MAMELHPFLEPDIRPAANWWYVVSAAGQNPTMRVGHSATYVPALQEGEHDRVFVIGGANPSQVFSEVYVLDLHTRAWDTLEAPGFRGRYEHSAFRVENHPGKIFVFGGATQEGNLNDLQSLDVSSGAWADVETSGEPPSPRTHRCATVVGSKVYVYSGGQSGPDPVSDRRVHCLDTHTMSWTTLTTRGDAPKPRHGHMMIPHNNRIYLHGGMAGATFYDDLHVLDLERSAWSNVRKKRSNPPPRAAHYAVVHSDAIYMFGGMSGAGALDDAYKLNTETNTWTKLDFEGPAPANRLDFALCVVKLQVPRASAVPAHAHGQEDDPSETSLKAREVLERELKPGSASSRDSVSDSSCVSEALFALEADPSAQGQQPSTETSGPVGDCGKVSAPLEGNTEEVTMVLVNGGMDTEGEIFDDTLVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA36</accession>
    <name>A0ABM0JA36_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 69 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005088927.1">
        <property type="nucleotide sequence ID" value="XM_005088870.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847384"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048732">
        <property type="entry name" value="CFA69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048733">
        <property type="entry name" value="CFA69_ARM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14716">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14716:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21049">
        <property type="entry name" value="CFA69_ARM_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 69 ARM repeats" evidence="1">
        <location>
            <begin position="47"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005088927.1"/>
        </source>
    </evidence>
    <sequence length="937" mass="106456" checksum="C952B36B05E99E47" modified="2025-10-08" version="1">MAVVQTVGQSKRLQSSLEPDKARIPLVTHIITDDDLGIVEGSKLQQVNLKRVIKLLTDPHSMMLYERHVHALTRMARHYNKGFPMKDLVMVFKILNVCADRVDSNPIYEQPIIEILKLCSFPFLMEKSSDELVYEQIVVESISQLGYLMRIPSSDVRKQICDTLLLFTSMKPTQDVQNFKPADLAFNRKMIEFSDISETLVKSLALLETDLPAKLKVLEILQIFSKNSVKNCDQMLFVDGGRRICSRLMDPDSSGQLLFRSVETLWNLMENGDKAVLAKQLNNLTCISQLRDAFVYQLTQGYSHYDRQLRNDLLVIATLVASQCPEAPFVETGFAKQLTLFATFQEVKSHNALVRHLKLLTNHEDFELRKLLFNILVVLSKDSTVVSILSDGHLLLALFSFVHANDKKTGPREWNPAQFEELQLQAMACLCTLCPLLLEDYMTCQGSTRLLLLLEWCVGPDEFCGQGNSFHGTGGRGNKKAQMRHCLRLMRSVVSTEDEVVLQDLADQGAINQLIALCTKWVLNTAFTQRTDENDVVEIEMQSDILFILSCLCDGDMHRKELFGVQGVDMVVRYLRTDTRLLNSGLGHHKLLLASIDCTWCAIVGCFVTEDYFLEKEGVFLLFDLLEVCPKNMHNVILGCLLDLCENPKTVNHVLTWRGKDGCTASHLLCQIWRLEESEIGVRRDTQGAITDVHHPLMGHIQVEMGTVAMPASCVSQAIADVGENMRAKVYSLFCKMGFTDLPGLTVEDHVTLTIIEKYLDFKMGEVWTETIGELQAEQVRPVTPDQEAIEAITRAIEERAQIVVTTQSELLEAQKNQDILDEQEFYADIRENHRQKEKAIADFNDYVSRTSNFALLKAAKERQEISIDASRMQPKYKEQEHFHNVDLPNLTTTVFSGKHVTVMNIPKHSNDDDIESKFEPVLEPMMERRIFKHLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAS9</accession>
    <name>A0ABM0JAS9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-phase kinase-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089404.1">
        <property type="nucleotide sequence ID" value="XM_005089347.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854298"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005089404.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18575" checksum="BE441ACAABE9D871" modified="2025-10-08" version="1">MPMIKLQSSDGEVFEVDVEIAKQSVTIKTMLEDLGMDEDEDEPVPLPNVNAAILKKVIQWCSFHRDDPPPPEDDENKEKRTDDICSWDAEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKSPEEIRKTFNIKNDFTPAEEEQVRKENEWCEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBJ4</accession>
    <name>A0ABM0JBJ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuropeptide F receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101856305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089880.1">
        <property type="nucleotide sequence ID" value="XM_005089823.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856305"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="64"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005089880.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46793" checksum="4073D3A9D8FEE345" modified="2025-10-08" version="1">MVDLTVNLSSMWAEFTSNSSNSSLTKDQLRFILTQDIHERHFDRVTETVLVLFYSIFITFGALGNGLVIFVVVRNPSMLTPRNIFIINLAISDLTLCLFTQPLNLYLLLFKQWTLGQFMCKFVTMAQGTNLFVSTISITAIALDRFQVIVYPTKDSMKKLGAAIALISIWLISFLMASPALLFSMVDTLQPLEEVPGVYVYRCLEDMSLDIEKRAYSVAQMVVQYVLPFIILSVAHLRICNKLRYRMVTTQNVPNSAATTSYQRKKNERRSRRKRKTNLLLAGIAIVFALSWLPLNIFNLLVDFKGEYFKGHVDTKFVSAICHMLVLCSACLNPVLYGWLNDNFRAEFVKILCCTCCEILRTKLRRVLCCSRQAAGVPAITLTKVSNGQSIALDEGMGNGKSNALTVQYQTQLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JBZ0</accession>
    <name>A0ABM0JBZ0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 236 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101861861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005090171.1">
        <property type="nucleotide sequence ID" value="XM_005090114.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861861"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF151">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="759"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="831"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="981"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005090171.1"/>
        </source>
    </evidence>
    <sequence length="1047" mass="116111" checksum="C527DC3DADAC96D9" modified="2025-10-08" version="1">MDNLPPSGFQFTGDDYGPVDFPSSLPSEMQAGMAFAGGGPVFPQNQRGSSYAMSPFHMNYSQQASMPSMSSLPSSTFRTRFTDYPPDQSPHLPMPIPSSASGIISDRLPSFSSIVSSSGSSSADPSKSSQALYSGISSSLAGQQHAFQPSGSRGLPAHFDSSYSEQVPGKNYSKSSPLGSTSPGMSSSSNFNNIPHSSILQHSSHNGSGHLPALSPRSYKEEPTTQQQYLASMHMDRHGSYPHGALAGGQNPGESMTLPKFKHKYLSHSQPAPRRHIGPFKFYILGSTSRGSIINKGSQTNEENIGELKIKIPKKEIYRSDSETEMSDDNEDLRRRSRGTSGGTSNSRSRGQTSHASPRITFPYDPVPAATPTQNKEYSDYNKNSKMKTIISPSFMDSAGKATMTTCVANKATIVTVGIVSRPGKLHSAEPVNSQHRGIMSTSDGYRNKHFDPQHPENYEQLMEERKAKAKDLEQERMEVSVRIDDTQYVQVGNAKRWQCNQCDKSYTTKHNLVMHVLDHEGIKPHLCLKCGKYFKQLSHLNTHMLTHDQIKPHTCNMCGKGFTQISHLKRHTAVSEKNGYCANLRSKQGSSHHHSPSAAPPMGTPTALISEARQFQDQNQSFDSMEGYDRDDLKLSDDKLGPPGKLMCRYCDRKFRYPSQLKDHMQSHNGNRPYMCTECGMDFMKEHHLKAHQFTHTGLKPYTCDICGRSFNQRANLQRHKLIHETHRTFKCNTCGKLFTQPQTLKAHQVVHADRKPFECTICGKEFGRYHNLQGHMHMHTNSKPYMCFCGSAFTLKGNLNRHKKVKHGLNETTDVMEEDAVNFLSSLSERARDDSGPLDGDGECLSPGDGGDSGDGKLSRKGRKSIPRKITQGEEEEGAYPQGAGAPGEAGMPQDGAPKPFVIQNPDTDEEEEGGTDQGHHPHHHQGDLHKDAVNGVMMEQPGMGNPMMNFQPLNNAGLGQQLEEGEIAMTRKRLYEEEVNDMVDKRPRRQSQRRSPKVQAGDMQQSDSDEFDGGNMDNTDADWVPGSKRRYRSKVDLSDKSKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCL0</accession>
    <name>A0ABM0JCL0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 593</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101860782</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090598.1">
        <property type="nucleotide sequence ID" value="XM_005090541.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860782"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005090598.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15800" checksum="727DD1732859609B" modified="2025-10-08" version="1">MGRYRRKKMHKGDKPLKEKYRTKRRTRDLDQIHDDMKSPDKMVNQPVDLDKPGAGQFYCLHCAKHFIDEKALKDHFKSKPHKRRLKALETEPYTQEEADRAAGMGSYIAPRKLEVQKQETNDDSDEEGDLSMKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE09</accession>
    <name>A0ABM0JE09_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fibrinolytic enzyme, isozyme C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101848333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005091542.1">
        <property type="nucleotide sequence ID" value="XM_005091485.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848333"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045428669" evidence="8">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005091542.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="28905" checksum="0E02369F451A1F45" modified="2025-10-08" version="1">MKLVAAILLCLAASALCEKRIINGESAPLYSHPYIVSLEGLVDSFFFTYWKHICGGSLIDRQWVLTAAHCVEGMGKSKLRVKLGVITLGETNNYQQQVAISQVTVHGQYSSTASGIPNDIALLKLSQLAVLNKNVQIAQLASAGSSFYNTECVLAGWGKQNEGHTLVDATELHEVNITKISTAECRREWPGEAITDKHICVHDASPPAGQRPSGCMGDSGGPMMCGPRHNILAGVTSWGERTCSGTFPSVYTRVSAYLGWIRNNGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEE0</accession>
    <name>A0ABM0JEE0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101850778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091801.1">
        <property type="nucleotide sequence ID" value="XM_005091744.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850778"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="269"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005091801.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35507" checksum="AB01C146B470DEFD" modified="2025-10-08" version="1">MGNSRSSKNCAASMTMGMPQRERDLHIAVVGNDKSSVLSVLNQGVDINYPWSNPAVPSVKDSTTPLIAAVSLNHVEIVMILLHSGAALNRTDRNGCTPLYKAAFHGRMVLVDVLVKAGAEIDKADKENQTPLYICVQNAVVHSSIATVKRLLAAGASVHITDRYGRVPLHSAAHWKLKELIRILLEAKSYVNVVDKQGRTPLYVCVVSLSTGIYKEDLKYQVPCIKILYTAGCDMLNLEDWLRWKGPGVPPEMLTGDENFLTWYKAAMTSPPSLRNLCRKVVQRRLVAYDCPGLVKCVEQLPVPPSLKVYLSRKMFHLPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JF90</accession>
    <name>A0ABM0JF90_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101853225</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101853225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092346.2">
        <property type="nucleotide sequence ID" value="XM_005092289.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853225"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005092346.2"/>
        </source>
    </evidence>
    <sequence length="157" mass="17481" checksum="BF1C2F31F907B3D5" modified="2025-10-08" version="1">MTDANGAVLACSSSPPLYQVTVILSLCASHYLKINSCFAGVRYDLVSAYADVIQDTRSTLKCPLSGCREGTLCLPFINGDFRFTEIRKTDKVQEKPKNVISSEVEEELRTYHIIVDVDMTTTSLDSLFSEEDAIHEKKRLHSVNSSGDDLVFNSKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGU5</accession>
    <name>A0ABM0JGU5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">DNA-binding protein P3A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12" type="primary">LOC101847640</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRF1/Ewg family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093358.1">
        <property type="nucleotide sequence ID" value="XM_005093301.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093359.1">
        <property type="nucleotide sequence ID" value="XM_005093302.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093360.1">
        <property type="nucleotide sequence ID" value="XM_005093303.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824358.1">
        <property type="nucleotide sequence ID" value="XM_035968465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847640"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039142">
        <property type="entry name" value="NRF1/Ewg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019525">
        <property type="entry name" value="Nrf1_NLS/DNA-bd_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20338">
        <property type="entry name" value="NUCLEAR RESPIRATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10491">
        <property type="entry name" value="Nrf1_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nuclear respiratory factor 1 NLS/DNA-binding dimerisation" evidence="7">
        <location>
            <begin position="67"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005093358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005093359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005093360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824358.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="50426" checksum="58757DD3E05B6D74" modified="2025-10-08" version="1">MMNSGIGNGVHGTMTGGITIGGSHINTGIMEDEMSDGPSSPESAFDAADLIHGSMTDEVTAQLAAAGPVGIAAAAAIATGKKKGHPHQFETNPSRRKRQQTRLLRKLKNTIEEYTIRVGQQAVVLCCTPGRSPGTASSLYKVFGSQPLENVIRTCRNVVTQELENALQEQAAQNQGDNTHLHELPPLVIDGIPTPIDKMTQAQLRNFIPEMLKYSTCRSKPGWGKPECRPIWWPADLPWANVRSDARSEDEKKRVSWTEALRTIVKDCYKHHGREDLLHVFSEESSTAAVPSGAQFAGTMLQTINNPDGTVSIIHIDTGPSGNSVVTLPDGTQATVVHAVSAGPHQVNMTEATQAVQTLAEVAANQQEVTPVSQVNPVTVEMADSQTAMTAFTAATLSQNGQIILSGDGSLGGIVTIPASMYQQMTGLALPDSAQATIQQVAMAPVPNMKTEMAEVLQGVEVTSGEVVGQQQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGV6</accession>
    <name>A0ABM0JGV6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101856246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="RefSeq" id="XP_005093392.1">
        <property type="nucleotide sequence ID" value="XM_005093335.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856246"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="124"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093392.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="41987" checksum="C1D42914A06F96CC" modified="2025-10-08" version="1">MAASMYIVALRRGSVLPLQHLHNASSRVPTLDTRRHASLRKDQKEKLADGPSLEDFIAGDVPEYSGEGSIKRVKGERLRLPEWLKTEIPVGDNYKTLKKSLRNLNLHTVCEEARCPNIGECWGGGEHATATATIMVLGDTCTRGCRFCSVKTARNPPPPDPEEPVNTAAAIAEWGLDYVVLTSVDRDDMPDGGAAHFAQTVREIKSRNSSILVECLTPDFRGDMEAVTVVADSGLDVYAHNVETVEAMQWMVRDPRANYAQSMAVLTHVKKRHPKMVTKTSIMLGLGETDDQILQTMEDLRKIDVDCLTLGQYMQPTKRHLKVKEYVHPDKFQYWQEVGDKLGFAYTASGPLVRSSYKAGEFFLKNLLEQRKSESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGX7</accession>
    <name>A0ABM0JGX7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101863416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101863416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005093424.1">
        <property type="nucleotide sequence ID" value="XM_005093367.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863416"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17101">
        <property type="entry name" value="FERM_F1_PTPN13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047145">
        <property type="entry name" value="FRMD6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429">
        <property type="entry name" value="FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429:SF5">
        <property type="entry name" value="PROTEIN EXPANDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="14"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005093424.1"/>
        </source>
    </evidence>
    <sequence length="1379" mass="151878" checksum="4F4585A03E249053" modified="2025-10-08" version="1">MASKQAAASGKKRKIVNVHLLNGDERVIHVDVKSKFQEVFNQVAGQLCLRETEYFGLAFRKDNEYHFIVLDEKIHKLAPKQWKSGSGEGTDSQGKALINLWFRVQFYVDQVILLREKVTRHQYYLQLKENVLQYNHLYNEEKCFQLAAYALQADHGNYLAERHQGGYFNPALYFPQWMLDRHGVDYLANNMPTIHKDLHNLTKNDAELRYIRNASMPPGGHNLHFYTVRKRKSDKVCDTWLAICAKGVEVYEDDAGYKNHISTFLWKDIAKLYFDKKKFEIRSVQSAGGRRFMYYTDCDVKSKYLLTICRSTHMFQMAIQPKLMEIHHLDNEDQKRYRESYVYSEGREKCNLQHSPSKSMSVTGSSTNQRFSVISDASSNTTSGIVSDRMAVSFDDGDDHTREFMIDCPPRSAVGGTPSQIRSKFQPSFSFKQSPQGSKASPVSAHPHSLDLCKPDAGVSPSQELSPTSSTGSWRLRHHPGATPMRLMSLPSPTTPTQDTPGKGLRRSGGRRDSFSKSSQLLPPGSLLLTSGERNTSGDSAVSLSGIFCGSGQDKLAPLSLPQSELRGCLSGSPGPGGSVQHGGGGRGSGGSSTYSLTPPLNLAHLKKTGAGPSPPTSLNFAGVSSGGMKDSSSPRGGPGAYSLGRRVQGERSPREQQLKSLGSPRELCQQQQPAYKLLPSPLDISDKLSLSSPRANIHEHYPKPVGSPRGEGREVTSHKTLNSPQDLGGKAYNKPLPSPRDKISEQLKLSGPSTSSTHHAMLDFPHTLPASPSPRATESVYSFPIISALQQQQQQQQQQPVQTQSPQPQQLTNIQAPLPPPAEVGAGEFHQSRGVEQQPLEGSSSGVLTDHTLLASLMQHQQQQQLTAAEKQSVHLQQQQQHQQPLFKSPAPAPSATSSSAVTDHYLLALRQGNAQLAEKSPSAQRAGMGGIKNILEKLPAPQAGLTMPLADHMRADQKQQHQQVAQPLDQRLQQQQQVAQPLDQRLQQQHQNQQQYQLQDYIPYGVAVKDSSPQNKQIISSDAGAEMEENKENVYHQANDFNSGRDEQQEELMEEPVVAEEECERSSSTANISEAESRNSESTSHSGNKGVLHPELKQILGQSHAISLPLITALCNDSSLVQASRSQSGSRSSYDTSTMRSTDSRLTRLSHDTDPRRWSSCCQAAGGGVPEVMLSVQSSRPYSWHSEHFDLDSHSATHPRQLALLPAPSEEPNLPTTSPPNPRAVLINNKQLALAGDNSEVGGGKNNVLLLPQKMIESDPGPSSPHTKSGYSVNISWWDAPPSAAGSDPGSSSWVDALPYSLPPQHLPNKHPGTSSMQHLQHHHHPHPHHYHQHQHQQQPLMPRQNMVPHKLSSGGHRDSDSSIAHKQIMKENIGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHF5</accession>
    <name>A0ABM0JHF5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101851251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005093728.1">
        <property type="nucleotide sequence ID" value="XM_005093671.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851251"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03075">
        <property type="entry name" value="GST_N_Mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003081">
        <property type="entry name" value="GST_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF222">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01267">
        <property type="entry name" value="GSTRNSFRASEM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="92"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005093728.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25444" checksum="9137A3322501AEB3" modified="2025-10-08" version="1">MAQKLKIGYWKIRGLGQPIRLLLTYAGAEFDEDQYEQGEGPEFSRDEWLNVKPKLGLDFPNLPYLFDGDVKITQSNAILRYLGAKFSLLGEDPKVQAYSEMMLENAMDMRNALVRLVYSPGYDENVDKYFTQVDEKFKQFEAFLGKKDWFAGGKNPTICDFHIYELLDQHRLMRPESLKGYSNLLAFLDRFEALPQIKAFLQSDKCIKRPVNNKCANWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI57</accession>
    <name>A0ABM0JI57_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101849360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101849360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094163.1">
        <property type="nucleotide sequence ID" value="XM_005094106.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849360"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005094163.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14510" checksum="E24FB4F378304DED" modified="2025-10-08" version="1">MADETTPRPPTKKEPEVLTDSSLLLLANGVGRQDLKGVELAMYLNIPTTTIVRCIGDVTESSLTAEGSENDRMAVAAKCVLLWKEMTKDNKTRERVKSLEKALREIGKGDVADTFMERHSNNQELSNDIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIN3</accession>
    <name>A0ABM0JIN3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylamidoglycolate lyase</fullName>
            <ecNumber evidence="2">4.3.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101849446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.3.2.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005094514.2">
        <property type="nucleotide sequence ID" value="XM_005094457.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849446"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14958">
        <property type="entry name" value="NHL_PAL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000720">
        <property type="entry name" value="PHM/PAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00790">
        <property type="entry name" value="PAMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047236669" description="peptidylamidoglycolate lyase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="9">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005094514.2"/>
        </source>
    </evidence>
    <sequence length="384" mass="42666" checksum="051ABFB9E4BABB01" modified="2025-10-08" version="1">MTKAILIALLGLLAACTAVPAYFPQIDDLDRNDRRDYLQYLQALQTPQEVPATVFSTDGQGLGQVSSVGVDSNGDLFVFHRADRPWTAETFEDFKDTLSENFKSPIQKETIYKLNPVTGKVITKLGANFFNVPHGMNFDANDSLWLTDVGRHQVFRMPKGASTPDLILGEQFVPGNDETHFCKPTDVVVASNGQFFVTDGYCNSRVLKFDENGKFLAQWGTQTGDSELTPYTLDIPHSAALVEELDLVCVADRENSRAICYNAGVTSNRKVGEYNRTIVHRGEMGKVFSIYFNKAEKELVAAGEISTVPYVDRGELEFLPRAFTYSLDGRNLQQWAPITLSIAQDGPSLIHDLCTSKDGQEFFLGDVMQQKIFKYTKVTAPVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIW9</accession>
    <name>A0ABM0JIW9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuropilin and tolloid-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094706.1">
        <property type="nucleotide sequence ID" value="XM_005094649.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852757"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF69">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="45"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005094706.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="33627" checksum="14A3D6D26027562F" modified="2025-10-08" version="1">MVVSNGPIIGVSSRKFLYFVIVAAGLLLAGTKSLDYSLLYMESACGTTITFTESFQMDSSTGITYKNLLDCELTVTGPSGHFVVAQITRFELEAALTGSCTDYLDVHDGTSTSATKLNSSPVCGSGTSIPSNFTSSGDSMTLHLLSDSSGVYTGFNMVFVAATSEPCSSSQLNCNTSVCIPSSLECDGFDQCGDSTDEQDCAAKASSDGPDVVMIVLITLTVLVVIGCVVAFVAYRIYDRNRWKKFLHGKMDDDDGIVAPGPSYPLTYQYYKGIRGHPVYQANSSHYTDVEKDTTTTMTDSGHSFDNKAQSSVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JK78</accession>
    <name>A0ABM0JK78_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein disulfide-isomerase like 2-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101852541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095652.1">
        <property type="nucleotide sequence ID" value="XM_005095595.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852541"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016855">
        <property type="entry name" value="ERp29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211">
        <property type="entry name" value="ENDOPLASMIC RETICULUM PROTEIN ERP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoplasmic reticulum resident protein 29 C-terminal" evidence="2">
        <location>
            <begin position="264"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005095652.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46978" checksum="BB1F38A39F064282" modified="2025-10-08" version="1">MAATRKYCRLLAVLFSCVVIFLTTGVRSLVHEVNSQNLDKFLSGKLFTLTFVDSPSCTRCRTLFPFFVQASQVFPNDPEIFFARTHDRKLQEKWGVTELPSLMFHMHGLGNHQYLDLDVTVDDIVDMIARLLHGNFAGLSRTYSVHVTPENFQEMIITPRQHVLLLLNDKKDTEERTNLDRVAYAFRKDDAILFASLDVSKYEKLRNERFKSRETPVLMWFQADEKDTPKRFGGVLSAELITMFVNERTGLNRDTEGGILQEAGRIPAADKLLNQYIEDVVDHVDERLVSLSSALTALKPSLEEYENEMLDYYLFVLDNIAMAGNVAILRELIRGEEEKLSEKEELSTKQRETLKRRKNVLTYMQSLVNEVKESRKKRKDDTKRKQQEETLILENPSKHDHVHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKK8</accession>
    <name>A0ABM0JKK8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005095901.1">
        <property type="nucleotide sequence ID" value="XM_005095844.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852169"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="49"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="152"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="5">
        <location>
            <begin position="382"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005095901.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="52767" checksum="9B0FA065DEC616C9" modified="2025-10-08" version="1">MLQCHDQLSRNSLKSFTMYSQQTIVLTLAFVLISGGTLKTADHGTGKAPQHIHISYGDLPSQMIITWSTPNKTDLSSVHYGRELLHLVNVEEGSSHIFVDGGTEKRSQYIHRVDLKGLTGNTTYYYKVRSEESESGAFYFRTMPEGQDWSPRLAVFGDMGATNAQSLPRLELDAAKGMYDAVIHVGDFAYDLSKDNGKIGDQFMQEIQSLAASVPYMTCVGNHENSYNFSNYRARFNMPNDNGKMYYSFNMGPVHFVSISTEFLYFPDYGFTQIYEQYDWLKKDLMEANQPENRSKRPWIVTFGHRPMYCSNNDNDDCTSNESLVRVGVPLLRILSLEDLYYQQGVDLSIWAHEHSYERLWPVYNLKVRNGSYESPYTNPGGITHIITGSAGCSERHEYFQKNPPPWSAYHSSDYGYTRMTFANKTHLYVEQVSDDKNGEIIDSFTLIKEQHGPYGDLNNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JN21</accession>
    <name>A0ABM0JN21_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Disco-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101852922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097524.2">
        <property type="nucleotide sequence ID" value="XM_005097467.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852922"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005097524.2"/>
        </source>
    </evidence>
    <sequence length="1569" mass="171863" checksum="FEB4F3EA77FB4626" modified="2025-10-08" version="1">MGDTDIDVSRLPDDIRERLAELDLELSEGDITQKGYEKKKSRLLAPYAKQQNNEAGTGAGAPSPSTAAQRRAQRRLTREDNRYHSEIRTEAVMQALAMQNRKVPVMPLPSKRTSVNYQGQQRRDRQDSSSDDDSIFDEEQLRNFQRGGHARDSGASSSSYSDQGASPYHGGGGSGGAGERPRSAQFSNYVIPGNTARHALADVMQNARHSHHISPQPPDVTNNAKSTRQADRVGRYNQSSVRMNASGNVTGMQEEDAPAHGKVSAKIQQLLNTLKRPKRKPLREYFVDEEEATLETPVSDPNAPKPEGKELIPQPGDPLVVPSGLPRNLEAALQRYGSSTYKANAITVLDANGKPSYNLTYGKLLSRTQKIAYSLLCKVGQKGEPIRQGDRVALVYPNNDPISFICAFYGCITAGVVPVPVEVPLSKRVGGSNDAGGQGVGFLLGSLNVCWALTSENCYKGLPKSSNGEVVTFKGWPRLNWFITENLSKPSKDWQPPLRANDDVPAYVEQYALNKDGSTVGVTITRNTMLCHCRTLTVAANYTEGEVMVCVLDFKREVGMWHGILCSVFNGMHVIFIPYSLMKVDPASWMKMVTKYKATVAVVKSRDMHWGLLAQKDHKDINFSSLRLLLIADGANPWSLTSCDSFLSAFQSKGLRPEAICPCASSSEALTVSIRRPGRTSSSATGRGILSMQGLSFGVVRVDSENSLTSLTLQDCGQVMPGATMVVIKLEGPPQLCKADEVGELCVSAGYTGSSYWGLQGITQATFQVQPVQEDGTVQTDRTYVRTGLIGFLGPGGLVFVCGSKEGLMQVSGRKHNTDDIIATVLAVEPMKFIYRGRIAVFSIRVLKDERIVIIAEQRPDCTEEESFQWMSRVLQAVDSIHQVGVFCLALVPPNYLPKTPLGGIHLHDTKKKFLEGSLHPANVLMCPHTCVTNMPKPREVHPDVKPSAVHVGNIVQGARMAWAQGRDLGISEEDADTSRKHQFLTEILRWRALTTPDHVLYTMLNSRNQPSATYSCSQLHKRAEKIGCLLMEKGKLNTGDHVALVFHPGVELVSAFYGCLYVGCVPVTIRPPHPQNVSSTLPTVRMIVEVSKSVAILTNSATIKLLKSKEASVIVDSKTWTNLLDTDDLPKKRLAAVYRAPTPEMICYLDFSVSTTGMLAGVKMSHASATALCRAQKLQCELYPSRDVALCLDPYSGLGFVLWCLSSIYSGHHSILISPSEVEINPAVWLTAVSQFKVRDTFCSYGVMELCTRGLGTSTNSLKTKGVNLSCVRACCVIAEERPRILLTTSFTKLFASLGLSPRAVSTSFGCRVNVGICLQGASCPETTTVYVDMRALRNDRVTLVEKGSPHSLCVLESGKLLPGVKVAIANPETKGQCADSHLGEIWVSSPHNANGYFTIYGDESLHHDHFDSQLATGDVGSSYARTGFLGFIRRTELTQSDGERHDAIFVVGGLDETIMLRGMRYHPIDIEMTVQRSHRKICECAVFTWTNLLVVVVELDGHENEALDLVPLVTNVVLEDHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDGFLTDQLDPIYVAYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNJ9</accession>
    <name>A0ABM0JNJ9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005097874.1">
        <property type="nucleotide sequence ID" value="XM_005097817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852174"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005097874.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21948" checksum="2C5E69D8690DCCC4" modified="2025-10-08" version="1">MDAVEQHDAFFNSFNLVRGPCLGSGAVGEVVLATAKHNSSLKVAVKIVTFETEGCKGDFLSEVGFLRDLRHPRILKMIAFAMDDHQGFMLSTYFKNGTLCDIMSSDHPVEEPRILRHILDVASALQYIHGLHIFHQDVKPRNILLDDQDRAVLADFGIARQASDSSAMVMKWRTTPGYSGPETRKRRPMSPFKPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP62</accession>
    <name>A0ABM0JP62_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Epoxide hydrolase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101845545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098269.2">
        <property type="nucleotide sequence ID" value="XM_005098212.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825620.1">
        <property type="nucleotide sequence ID" value="XM_035969727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845545"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="84"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005098269.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035825620.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="40279" checksum="4946C5E577D15EB8" modified="2025-10-08" version="1">MGVKRIQRGLYLLIIYGLAFATAFLTIVRVGVLLVTKGPRKMLHKKRRETEPLCFSDPTFGTHGYLHLEEVRLHYVSSGSPDKPLMLLVHGVLENWYSYRYQLREFSDKYRVVAIDQRGCGDSSRPSGIKEYQLERMVKDVKQIITALGYSKCVLIGHDWGGAVTWAFAGCYPDMVEKIVVCNSPHFHCFRNYVRTHWAQFKKSWYFFFFLLPILPEIYIGLNDYGFLDRIFLGKTAGVHTGAMTQEYVDAVKYIFPNISSMTPSINYIRANLLHPPSSRYGQKVTKPVLLIWGCRDFSLENGLAEKTKDFAYNMDIKYIKDACHFVHMDEPEKVNSYIREFLSKQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JP88</accession>
    <name>A0ABM0JP88_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Organic cation transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101858268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005098324.1">
        <property type="nucleotide sequence ID" value="XM_005098267.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035825639.1">
        <property type="nucleotide sequence ID" value="XM_035969746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858268"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="19"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005098324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035825639.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="60382" checksum="D880C090A9E22615" modified="2025-10-08" version="1">MSEYESILEQIRPFGPFQVRIFVLVSLFETPLAWAMLVPIFTASNPGSYCSYMDPDKNQSLGAFSSYNSSSSVDTCSKNESVCGEVVFKSTFTSVVSEWSLICNQNYVGDLISSLQMAGVLVGAVLTGQLADFFGRKKVLFGEYSLLIVFWFSTAFAGSWQVYAALRFFVGGLVGGCLVVNFVLPLEFVTPKWRTFCGCVGFWAVGLMTLALWAYFIRDWRTLNIAMSATSVILLPLWWFISESPRWLLSRGHIVEASKIIKEAAVFNKRPVPDLSSLESYVKREKIKKATRRQYSYWHLCTSLSLGKGTAVCMFGWFVASSVYYGLNFNTRNLAGDRYLNVFISGIVEIPALLFVLYTNNKLGRRRTTFLLMLTASLTCLSVLVIDLTGNFDKLSALTITMAMISKSFIAGGWAAVQVFSAETFPTVVRNIGVGACSMSARIGGIVASQFVFLGESSKAIPFTIFGVLTLLCSLSMLLLEETVGVPLQDRIHVEEVIVTASPQSEALVTSNGCISKEKEENCTSVQETEKALVMQNGHHGVAVDMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQI3</accession>
    <name>A0ABM0JQI3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101860740</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099190.1">
        <property type="nucleotide sequence ID" value="XM_005099133.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860740"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042848">
        <property type="entry name" value="Rpp38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46948">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46948:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="2">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099190.1"/>
        </source>
    </evidence>
    <sequence length="710" mass="78254" checksum="8C6D154A80584DD7" modified="2025-10-08" version="1">MAAPTIAVSRRAATLTNLSKREKSKKGAKSKNLLCPELHEWPRPSSEVEDEILSKLTECLKEVPSLLKAKKKDHTQDDTEKKANMRSQLMIGVNSVFRGLERNSLECVLVSGMATPAIIATHVISLAEEKGCPLLCIDRLAPAVADSTDSKCCPLAIGFKKMVEGAKRDFEDVISLILANTSVKTECYVPSHTSALRPTEEPVPGENSLWPFCFEEDKEKEVLDMLVRTFSDAPKEVVKDEKKMQKKKKKKQQKKNLKENFCKSFSHQFEVGKRTVLQILDRGKLQLILVSGELRNVLAAESSSNNASSSLLRLAARKGCLIVCLRGMIEVLKPFFGGAGVAFLGLKKFTSLENPQELHFQHVVDKIKEKLEGLTQVSLPAMTDGGAMRSTMLPLTGTSQLEGSHRAETMSENKTSSAEKMESDEEESKTGSVEKMESDDEEADEEEDYSYLYVLKKDSKELAERREKEKREAEHAKKDASFGTDFISLSGGSQSSTKKPDVPTHRQKDCSSNKGNQTSVSKNNSGEKDKQVPSGVASSENIAISSPSNGKDENFLAFSTSDNVSSTSSLPEERESTPSVPDKEKTVEKNDTEMECSGLPLFLLDRSRQPDLTQSKKGQSVPSSQSINYGSDRKSLSSSPQVLGDVGGPSSRKGEEFLSLSLSSSSKNAKKSLKRKMENDSSFISFAYNETNIKTMVANVDKKRKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR20</accession>
    <name>A0ABM0JR20_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC101857722</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101857722</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099520.1">
        <property type="nucleotide sequence ID" value="XM_005099463.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005099521.1">
        <property type="nucleotide sequence ID" value="XM_005099464.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857722"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099521.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16437" checksum="DB97B5132C478D2C" modified="2025-10-08" version="1">MTSTADPQYIRSVSVSYPRCGSGVSLRSTLSGTNYVIQRSRPRTAEDITHSARDQADRILERERTGMLDELMFLYGRNVSNSFDFSPTDAPKPPQKNYSTPVLSSPWHMNNSAFLQMYRASGRCPRKRQFPQFIPRPLTRETNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JRN8</accession>
    <name>A0ABM0JRN8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein SSUH2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099980.2">
        <property type="nucleotide sequence ID" value="XM_005099923.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849056"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099980.2"/>
        </source>
    </evidence>
    <sequence length="424" mass="46500" checksum="255055B5FAB712F8" modified="2025-10-08" version="1">MSMSYSRDSTHALLPSGQAAYPLQGASGHPPPGGPVPGYSSPGQPAAGPPPAFKEGVPVQGPRNDPSTTAPRATAPSLDQMDKLPGYDRIGFDGASLPPPTYKESQREPPQRDNIESVPTITEDQARSALLQFVSEDCCYGKRPAVEMKLNELKSSSAFHYTLETFGEGRSTKWTYEPFNGQHVAMTGPPPGPWDVPARPPQMFHTAKLDIEVPNTASVKPCHACFAMGFQRCTGCQGKGRVECNTCRGSGQEEYEEVGEKKKRACTKCNGDGTKRCSNCDGAGQTQCSECQGKASLRWFILLTIQWTNHAEDHVVEKTALPVELVKGVSGHKVFQETQTRVWPVNHFPEPEINSASNNLVSEHGSKFPTEIILMQRHQVRIIPVTQVFYEYKDHKDSYFVYGFEHRVHAPGYPAKCCCGCSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSM7</accession>
    <name>A0ABM0JSM7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat and BTB/POZ domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101847117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100573.1">
        <property type="nucleotide sequence ID" value="XM_005100516.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847117"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18295">
        <property type="entry name" value="BTB1_POZ_ABTB1_BPOZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18296">
        <property type="entry name" value="BTB2_POZ_ABTB1_BPOZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="272"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005100573.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="54934" checksum="AF404B61D2D75448" modified="2025-10-08" version="1">MDIQDMFHACKLGDLQRLQYLVEMKEVDIDTRDKWDSTPLYYACLCGHRDIVEYLLDKGAKCEANTFDGERCLYGALTDDIRNLLKSYHVISSRTIRRELYEEFLRRLLQDRVYSDVVFRVHGEEFPAHRCILSARCLFFANMFKTKWLNKPVVELNHSLMSEGAFGSILQYLYTGSMGVSMDLVDDCLKLARQCQLYELMTEIEDRMKKTLSWESSKPGVRVTTLVLESQGSDVLQRDLAQLAHWALPDQLNSWVVGELPFEPESLPLSYPDICFCVQEHKFMCHKVFFCGRSDYFQALLEDHFGECQQGESVPTLILHDVSVDVFVRILMYIYTDSCDLHADFVGDVLMWADMYLLPGLKRLCASSMMAYVDLSNVVSLIRTARLFNLPRLESHCAEFIANNLSKVISQEDFKALVIEDASNVQQREETDSIDIVDEIRFYISSFVLTYSEMEEANEKLRLIDDMLEELDIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSN9</accession>
    <name>A0ABM0JSN9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101853095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005100599.1">
        <property type="nucleotide sequence ID" value="XM_005100542.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853095"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157:SF3">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="338"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005100599.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="61602" checksum="A6C533F3E0EF8585" modified="2025-10-08" version="1">MAYLPAGEEDGDYSDEWSLDEDDPPSNNVPQRSEPERTLNNYNRNNSYSNNNGRKNGSLPQPLFSRNVPNREEPSSKFSSSERTPWVPNFAAFPASSFLTAEDYQRAAVRGNLNVIERCLEQGICVDEALRHGWTALMFAGNYVQVEAVGLLLKHGANPKHAVDMYCPLMASCNACSGMDEQVGECVSLLVEAGADVNAKDRHHTTSLMLACREGHVSAVRQLLRLGAAVNAQDSKGWTALTWATQRQRKAIVVELLDAGADCNIQHLDKLTVKDLAAHLPSDEMLALLERRPANIVNSSGDTVIETAKMSATTGQLPAELSHCTLDSGEAQAKLTDLRYGELEVFLIGLDLPHLVRVFQQQLIDLNLLLTLTEQDLISAGVSQVGARKKILDAVQTIHKKDWEPSCLVSIHYNKRITCADAVAMVANSSKHVRYIASTMMYVKGQLRKHPDSITQSTDRVSPAQLLRHAEDAARNAATLQQELRTIQRELRLEMARRNCKPPDLIEQTDKRSRLLSVTSLTAATLAVTLSAVLYLNRETVSEFVSSVVPDFLTRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JSQ0</accession>
    <name>A0ABM0JSQ0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101858721</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005100622.2">
        <property type="nucleotide sequence ID" value="XM_005100565.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858721"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF414">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="873"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="1148"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="123"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="406"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="503"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="628"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005100622.2"/>
        </source>
    </evidence>
    <sequence length="1189" mass="133164" checksum="C0BB0DE22213FEDE" modified="2025-10-08" version="1">MASSKKSFCSRLQFVTTRKSSKKNQPDPYHDEDQSTSDASKNEDVLETPTSDPVESRVSQESCGHLQGVEESVDVSKKKDGGGSKAVKDTEDVSEVFSESEEPVVMERGVRKPVVKFTISVESNNEEDNTVFDLDVTQPGQDQKGTDDSKGGNMSKAKTASSPSLRLNLTEGVNSSPECGNSPEIRYSLDRVRLNSGESSLTSTPTSSRRRRQTFCGVSYMSRRNLSSSDQFEDSEDVLSASSSDFSPGSTLSSLGLEKFQGVDELSDDGSSEGKLRESTDFSDDACGEMRPSEHTVLTPVNKQLRIVTSVDRALFPHRRSSVSSPKVDRVLNFGRSSSENLEHIAFVDFLKRLKLQQYLKNFPPNMSLMDFKLTTEDELSEVYGVYDADGRKALLKAIEMAREDEESDTDSLSDFHSPATTSPLPSPLLRKCREELPFGGAPGGLRRLQRTLSEDTKQRRRESMPSTPTATAPPPPLAHTIGALIEPTNLLRMKNTALGQSAPSLTNSLKETVTRKNSRSYGRKSVVGATNSSPTLPPRCPSPQISAGSPHESPRNLSPNQHGHFAFQAIRKCDGRRWSFASIPSSGYGTNTPGSSNVSSRYSSQERLHQFPSHPTAEELHFLSSHFGSSDNMATSHDDNDLHPHANMRPRSRSLSSPARSPGVESEIVMMNSVYKERFPKATAQMVEKLKMFIDSNATLDLAQESDAVLCFLHYQVLELARDCLNKAAEKTVTKTYFYEMLDNLERLLQDARERSLDAYKNLYPLVKQLLLIVSRPLRLLECLEFDPEEFYMLLEAAEGQARQTIKADIPQYIISKLGLAGDPLTDITPVEQFDSVDHGPGVEEDKEEETEPEEQEVAALTKVKQPCEEDYDSIKLISNGAYAAVYLVRHKETRQRFAMKKICKQNLVLRNQIEQVFLERDILSFTDNPFVVSMYCSFETKKHLCMVMEYVEGGDCATLLKNVGCLPLDLARMYFAETVLALEYLHSYGVVHRDLKPDNLLITALGHVKLTDFGLSKIGLMSLTTNLYEDALDKDCKQFRDKQVFGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLVGCVPFFGDTPEELFSQVVNENIQWPDEEEWQVRDDAKDIILGFLQHDPLQRLGVGGAQEVKEHIFFSCVNWESLLRQKAEFVPQLDNEEDTSYFDSRIDRYNHDLEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTQ1</accession>
    <name>A0ABM0JTQ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase TRIM71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101274.1">
        <property type="nucleotide sequence ID" value="XM_005101217.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853393"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF51">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005101274.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44321" checksum="C67E44C905766FDD" modified="2025-10-08" version="1">MVDFQSHYRVYPHGFTSDPPRVGVKTNRELYHEEGRKVFRKRHDRPVHDCRHEVMKDHTDRQEFETWVLSHGMTETYRAVEDLHDKSEEPTPGTKKPDKLLYKLGETGSAPGDFRYPRGLCTTMDCDILVADSMNHRVQHLNQYGVYKKHVGKQGQGNEEFNEPCDVLELPNGDIAVADKKNKRVQVLTEDLKFKYSMPIAGEPFSLGCDRDMNVAVATTRKEIFIFNSYDRVMLHHFPVGAKGKSSGAPIQISMSNDSEILVSDPEDGHVYLYTLEGRCFCRFSPEAHSAGLSVMAGDVCFTPLGQILVVDVLNHVINVYTDNGEFLQQVLVPTDDVGSVHSLALGLEGHLVVSEFSVGGDHCIKIFRYRQCPCHEGKTPGSKKRTPVASPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU68</accession>
    <name>A0ABM0JU68_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862047</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101571.1">
        <property type="nucleotide sequence ID" value="XM_005101514.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862047"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101571.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16352" checksum="CE888E59FF416DEA" modified="2025-10-08" version="1">MRWQLSFWQQRRHGKTSGHRESSRQRRDDSMAYLNPGPRPGVNFEVENFRVYGHLRRAHTEVKNSLPTHTTIQTEKSLMCFEEQRRISPDAADYTTFYRCLSASVSAPVSANPSQRAPGPSRISVAPPSQDRPVEAPPPVNPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUW6</accession>
    <name>A0ABM0JUW6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fucolectin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101861054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102072.1">
        <property type="nucleotide sequence ID" value="XM_005102015.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861054"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF6">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="8">
        <location>
            <begin position="31"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005102072.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27595" checksum="82DC81E5B5E1CC52" modified="2025-10-08" version="1">MTWKPICFNKVHVTGILVFCFLSCVLSVNNRVNVALNKPAEQSGLLENAKFPNGSAFRAVDGDKDPEYKHGSCAHTTLKGAQKVPAWWMVDLQKQFQVHAINISNRNVYSERMQNFSVYVKRDNPMSDSEFPKESRLGELCLHRQLVIAASTTELLSCSSPVTGRYVTVYKFGFGPLVMCELEVLAEAAAEAGENRPAGMHYLNIKRRMKSLQSPFIFKSGLRSLLDCAATCSKEKEQRAFTGFTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVV5</accession>
    <name>A0ABM0JVV5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysosomal protective protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102723.1">
        <property type="nucleotide sequence ID" value="XM_005102666.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846434"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102723.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24423" checksum="03E17E0F8D92CE08" modified="2025-10-08" version="1">MWESGLDPYNIYAKRAGGVNTTSKLNISSRRDWWPLLGDKDNSYQGTTHSFSDESVLVTYMNRPDVKKALHVPPGLPNWVLCSNLPYTRIYDTMKDIYQMLHGMMHIMVYNGDLDMVCNYLGDEWFVESFGLAKAGARKPWLYPDSDSTKQVGGFRKDYSGNVRLVTVTNQGKLCKCSQTLSEIINNSLTGSLIKLLVNENSCLEILLLSASVSSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JVZ9</accession>
    <name>A0ABM0JVZ9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101846594</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005102810.1">
        <property type="nucleotide sequence ID" value="XM_005102753.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846594"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045552755" evidence="1">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005102810.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15302" checksum="DB5F51A2FE775653" modified="2025-10-08" version="1">MAKKGWRPWSAAIVVLLVVTRIDAICQKREVLGDLSIPGHHPLVVRYNVCVDNTTISPEPSMVQTGVATFIRECCGCRVSSVTEREHRLQTLHPPSETRSIYVPEIQACECVACDTNVYDWAQYFMFLNHRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY16</accession>
    <name>A0ABM0JY16_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">heparosan-N-sulfate-glucuronate 5-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101860429</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[heparosan-N-sulfate](n) = [heparan-N-sulfate](n)</text>
            <dbReference type="Rhea" id="RHEA:20197"/>
            <dbReference type="Rhea" id="RHEA-COMP:9556"/>
            <dbReference type="Rhea" id="RHEA-COMP:9557"/>
            <dbReference type="ChEBI" id="CHEBI:58041"/>
            <dbReference type="ChEBI" id="CHEBI:58287"/>
            <dbReference type="EC" id="5.1.3.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-glucuronyl C5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.17" evidence="6"/>
    <dbReference type="RefSeq" id="XP_005104223.2">
        <property type="nucleotide sequence ID" value="XM_005104166.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860429"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010598">
        <property type="entry name" value="C5-epim_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039721">
        <property type="entry name" value="C5-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059154">
        <property type="entry name" value="Glce_b_sandwich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174">
        <property type="entry name" value="D-GLUCURONYL C5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174:SF3">
        <property type="entry name" value="D-GLUCURONYL C5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06662">
        <property type="entry name" value="C5-epim_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21174">
        <property type="entry name" value="Glce_b_sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="D-glucuronyl C5-epimerase beta-sandwich" evidence="15">
        <location>
            <begin position="275"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="D-glucuronyl C5-epimerase C-terminal" evidence="14">
        <location>
            <begin position="425"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005104223.2"/>
        </source>
    </evidence>
    <sequence length="626" mass="70715" checksum="66B081C4453A9D2E" modified="2025-10-08" version="1">MRLSRAIKVVTVLGICSSVITICLWSSCSARQSDGFDRGLETLRGERGADENDVLTFHNRGTNSIASDQQPPLQPGDRDQAQADHWQQQQFQQQQLQQQLDYHEIDCNINNERTIKCRKEGPEVYVPFSFVKKYFEVYGDVVSTDGYERLEFHHANSIVHPPRATYTPSAMFMAFDHYNVENRERVKCITASEGVPITTQWNKEGYHYSIQVAQYGLSHHAKHIVTGEPDQLVLEDAEDEDGGVAGALADWQLPDKKSRLVLARHAPGLEEGGDNRVVEFLTSDSLSSKGITLPVDEKANKCVSMDVKFSTNGSVIIVVETVSRDRVSIHYVFTGAHIASDGKSNVFYGLGERHNEWMHIARDLKFDVQKGFSLKGGKPDKSHTGIARIVEIRLHGHGWLDNLTLSSAIHMEQFYDAANWLVKHQDERGGWPIMVARRVVPGVLELPPGWYSAMGQGQAMSVLVRAYLDSKEKRYLRSAVEALKLFEIDSVQGGVRARFLGQLDWYEEYPTTPSSFVLNGFIYSLMGLYDLKETASGRDKETAERIYSSGMKSLKVMIGLYDSGVGTLYDLRHITAGIEPNRARWDYHTTHINQVLQLMVIDDDPIFKTTVQRWLGYLQGRKSRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZT6</accession>
    <name>A0ABM0JZT6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101853958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105403.1">
        <property type="nucleotide sequence ID" value="XM_005105346.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853958"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="92"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005105403.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="65059" checksum="10753EB4EB07BB5D" modified="2025-10-08" version="1">MGCSSSVQQGDEAERSREPSDKLSQSAYRERGEQRNGKANVTPKHNNNNNRHQDSFKEEDEGFEEEFSDGALGLTTEKGYEEICQSLSPNNLFEDPDFPANDSALYLDPKRYRDSKIEWMRPQEILGDGNEAELITNGVTRDDIKQGILGDCWFLSSCAAVSRRDQLVTKIIPANQVLSGPMYNGLIRFNFWRFGEWVMVVIDDRLPTVKKKLIYGQSKDPKEFWVALMEKAYAKLHGSYEALEGGITMDALVDLTGGLAERYELTEYDPSLYKLILRAHKSGAFIACSRKGDWRSSTKADANGLIPGHAYTVIDITKIKHKMGEEKLLRVRNPWGDETEWRGSWSDNDVNWKWVDEETKEKIQQESKDDGEFWMSFKDFYRQFGEVTICLMGPDFDGDGVSDRVGHMEMIHGEWSLGQSAGGSRNNLVKFATNDQYLLTLTEPDDFNQETDDAESEGKSTIVISLMQEHRRSRRNVKVKSYQIGFFIYKTEDTNNKLSLRHFRYNPDVARTNCFVNFREVSGRFELDPGHYVIIPSTFLEDCPAHYMLRVFGEKKFSLKGPLLPTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K082</accession>
    <name>A0ABM0K082_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">rDNA transcriptional regulator pol5 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101858659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105686.1">
        <property type="nucleotide sequence ID" value="XM_005105629.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858659"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="703"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="765"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="771"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005105686.1"/>
        </source>
    </evidence>
    <sequence length="1176" mass="130773" checksum="4859F0B248F21091" modified="2025-10-08" version="1">MPAKSSEGASGASFRPQQAYLDVFWALSDGTDEQRNAGVLKLSQLVQDSEENEKAMVLKYCRERLIRGLSSGRKFARVGFSVALTQLLRTNKSLSTAEILKTIKEKLKIAGQDKRSKAEVGGIYLGRAFAFSSLIQSGRLAEMSNDDLGTVMEELLSMAQKKSYLKPVCNKTIGDLVQQISVDTFGESVWPKIRESVKLGWEQCSLDKLSLLLVCREKFPDVVNKKFLKKHWGFPVLAEENDSKLLRVILETVAQKSEILLQKILPGMLQNDRSVLSVWQGLGDPLMNQQAGKKAESASQRKQLGMKLAIALMSCTTDADQVLELMLCPSLAFAIFHGITQKNDPLAIAANSLFEQFQVKVKAEKINVQTLVVKLWKLSADQLEKQPGRVDIINSHNFTRLVDLMEKEEAAKFAETLTGVVKGANKSIKLSSNDKDKGKQMESCLRCLHHALSSPSITSPALQKSALTLYVRLAFFHVNKKNSSIQHCETTMNLEEGKSDQKLCKTFFYKGLDQLSTMGGGSQKRAEHLQEYISLLLHLSQYLQALMKADNVAPIKPWPEQLTEEWDKVYNLVTKIQKKSNGEPSASDSAFLLLFLFLGFHMLSDFQTASDLLQEVYVCYEKSSKKKQAKGSGDETELPWQEVVTEVLLNLMSLQSHLGRVVACVVLQSMSSHLTVGAVQLITEVLIPKAGRGDDAGGVLVEAEDGEDEDDDDLLDEDVPGEESEDDDGDNEDDESEEEEEGEDDEEEEMQVDEQFRASVKEALGAAAVKEDDDEKEDDDDELSDMSDSEMFELDDMLAEVFRQKKKASAGKKSREEKKKETANFRIRVLDLVEVLVKSERCGDFVTELLRPLLLLILKADAKENQAVVDKSKSLFRLLKSKAKGLTDTVHTADEQKDFFQELLDLAQTVTEASHVQDISLACHIVMNLNCVQAKNSGKKCMKLLEETVKNVITKGKSKQHLSFFSHLIDNDVARYQFMCPMMVASLKDSSIKLHGKVICYSLLSSLMKKTQKHVPETDEGSTSAWMNEVAAVVSESIRSLRADDLKVMYTKELLNVAVALQSRPDVLTQPPFGLEELQQLTGLKSKLNTDLRRLATKVIAGIERSQGKADGSNTKGQGKKKKKGKGKAGENGQAQVNGQKQTPESNSGKKKKRKQPETDANEQGEMPTKKKAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0E7</accession>
    <name>A0ABM0K0E7_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 208</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101849396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105819.1">
        <property type="nucleotide sequence ID" value="XM_005105762.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849396"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005105819.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20113" checksum="0040CD731217C10D" modified="2025-10-08" version="1">MPPKGKQGTKGKKQIAEENKSTLSFYIKVIAAANVLYYTVYYFLFWDYFTTTSAIMCVLCSVIYLATYQFMASMSRATYHEGQLIDPGVDLNMEAGMAEHIKDLILLTSMVQVATLMSNYFWLLLLLVPGRAFYMLWVNILGPWFFSPPQEEQVDEKKQKKMERKMKRQQIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0G2</accession>
    <name>A0ABM0K0G2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Hemicentin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101854974</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005105845.2">
        <property type="nucleotide sequence ID" value="XM_005105788.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854974"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF11">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046569039" evidence="11">
        <location>
            <begin position="21"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="119"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="376"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="611"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="872"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="707"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005105845.2"/>
        </source>
    </evidence>
    <sequence length="975" mass="108988" checksum="754680CC96772D5A" modified="2025-10-08" version="1">MAPYFSFISFLLVTFLMAQARELPLGEISLEQEPEQSYYIVKKRPAVIVCKARNAVDITFTCAGTQIPPTSVEMEDMSDVDPEVIQAKIEVTRADVQNYDDSQGAFWCECSALDIDGQPAVTSRRSFITVAHLKHRFSSHPQSRQASEGENVEFICGAPVGDPKPEILWRKDKKRLNIKENSRLVVTDQGSLVIESATQEDSGLYQCVAKNPAGRRESKEAKLTVSVYAESSEPAEEVSAGESSESRIRNPRQSEKKTYFSTLPQDSYYIRPDEKVTMECEATAADILTFRCNGQRMQRHQMQTEQGTDNAGNRVIKSVLTVEYADVRDYYSKAGDSSSYACVCVAWYQDATNPRGWGHISSDENVGIVLLSYLDRTFQVEPSDLTVGVNTDAVLLCEPPKGQPSPWVYWFKDRVRLDPRSDDHYSINAKGHLTIHRVQYDDSGVYNCLAENTVDQIQSKRARLIVTAEAPATTAAPVASMEDTIPSFPDQIPDFPVFLNDLKPQYDITSGDRATLVCSVVSADQLTFLCGQARIDSKDLKKSDSQYDNESGKRLLYASYEVTEDVLSGASDDFYCQCTAWYLNADGKWQMLQGNKGFVNLVEGEEREPEPKTYINDDFVYEPTDLTVDFEGEAELACEPPQGYPEPTVYWTKDGVKIKPELDSNFIVLEEGPLIIEYVRLGDEGMYTCVAENSAGSRVSRPMQLTVRGKPTTLPPTTPTTPMTPTPEPTDEDITDGTDLYPTTSDYYDYTAIKLTEPLFSMEPKEASYIVNDLPITLSCSVVAAKSLVFACNDEVVDETVKTGYLTIEPTSQQEIRDNSLTITKEQVEAWTGSDPFSCTCRGYYLAEGAEAGDWSFVESRAGTIQIAFFKKRFMMEPVSQNVQQGEDAELRCKAPAGVPTPTVYWLKDGYRLNEDETVMINEQGSLMIKGFSAKDEGDYTCVAENMLKRRTSKTASIRLAGEQTYFLMNWVCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0H2</accession>
    <name>A0ABM0K0H2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101861384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101861384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105872.2">
        <property type="nucleotide sequence ID" value="XM_005105815.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861384"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF8">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005105872.2"/>
        </source>
    </evidence>
    <sequence length="422" mass="48065" checksum="CF46CEBEE7D0D24C" modified="2025-10-08" version="1">MSEFLSAEFVERHIVSLPNQLIPEPWNLERHGVFYTLDLKMCQLKTFDFDFRWGDDSVPAPRLSSVLETPSKIVRLDVSLNELTSLSHDGLLPFRNLRALDASLNQLKYFQGVEVLRNLYSLNLSHNNLRNVDGLLQSQSLGELNLSNNNISDISAIPSLVNLRVFNISNNKLENLEGVSSFPRLEDINASNNLLRELVPLTSCLQLRVVTASNNRVKDLDSVLRLVSQQRHMQVLNLSYFRAMERDRTYQSDILRAANLMTLDNVSVRPMPPEAEDRQRHAGNMNTLQGAAKQAFDERMRVAKDRMEENISFLQRRILSIQNEYKEFEAKLKADLEACLRYLSSLSDAELASGGRTTIGATLPPGQSFYEPPDADTYRSRGTRNDRVADSKADYSNVRETDELLRCAFKELAKQKDKSMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0S9</accession>
    <name>A0ABM0K0S9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="10">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101848911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_005106072.1">
        <property type="nucleotide sequence ID" value="XM_005106015.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848911"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005106072.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16359" checksum="18BCE62A72762B07" modified="2025-10-08" version="1">MTYKKRKKAPAKKKRKVFFCRPQPLDAHNLLRPETLESLFYMYRFTGDKKYRDWGWQIFLAFEKHTKVPDAGYSSIHNVKDAGNPRFRDKMESFFLSETLKYLYLLFSDDPNLISLDKFVFNSEGHPLPIDKVAEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0T5</accession>
    <name>A0ABM0K0T5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clathrin heavy chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005106091.1">
        <property type="nucleotide sequence ID" value="XM_005106034.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854359"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005106091.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="43698" checksum="8851831D0760160C" modified="2025-10-08" version="1">MEPSLPELTRASPSPSPSHTVSGEVGGRGPPITINELVQLAHIGIPNTQVTWSRVTMTSDKWIAVRHDNRTDLSAKRAVVTVLSPIEGTISYAGSTSADSVLMNQSQPLIALKAGQRFEVFNLDTKELISKIKFHELVIFWTWLTTDVIAMVTDSAVYHWSIHKETAPTEQVFLRHNRLAFTEIVSYKADPSLKWLALTGLTPEDERISGVTQLYYVDEEITQCISAHAVCFSSYHFPGNPYPSTVFCVSSREAQDHGKVHVIELGPYKTGNFAPRNCYDHLHFLDDLERYDFPISLQISVEYGLLFVVTKYGYLYMCDMETAMCLCCTRVAIDVIFASALNTTTQGILAITRGGQVITVDLKKDGFISYLREQVRTAYRANRFEKVICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K3I0</accession>
    <name>A0ABM0K3I0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101859267</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005107911.1">
        <property type="nucleotide sequence ID" value="XM_005107854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859267"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="31"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005107911.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41727" checksum="9FD256AFC5BF69C4" modified="2025-10-08" version="1">MSTISDEVREQIELYMSVLITGPLALLGIAANLINFVTFLKQGVKDCVSVCLLALTISDFGSVLNGGSMQIFNIIKHLDIDSIIDPFAFMFIMAYGCILCYDISQGIIAFVTLERCLCVAMPLKFKDLFTFRRSLFVVIFLYAFTIAAYVPHFVTSGLHWRHDPVTNSSRIFVWLSDNRFEIDHYLNTFIHVVMTASYQFVVLISTQVMVIGLKRSSKFRKRKETADKATGNCNTAQVTYKRGDHSMKDHQANSQDIKQIEAHQMTDTQTKDSSLTLQNRRVIKTVSALAVIFLVCNAIRMVVIYTYMSNPELGFFKRYHNEVVVVNLFLFLSQAINSSANTLVYYHFNPSFRNIFRSVFCKCGKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4J3</accession>
    <name>A0ABM0K4J3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein beta chain, ciliary</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108588.1">
        <property type="nucleotide sequence ID" value="XM_005108531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860282"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: DYNEIN BETA CHAIN, FLAGELLAR OUTER ARM-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="2">
        <location>
            <begin position="144"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108588.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35291" checksum="0672EC42DA0432E8" modified="2025-10-08" version="1">VSAQQSEMDGKFAAMHRTVLLLKKYGQILAEKTQFLFNAAPGRWNNLKTKVSLAKQRLGPRIQEESASITQDLEAFAVRVMSLSDDLDNSDVYQRECSISDAYSIIEGFSKRLQVLENEAQDLIELQELLEASVVNFSLLPTVIEEQQSEWKRHRWQKMNTKFLRDETNKQLDIVRALPEDVFTWDVYMGLHESITTIQACLPLIDDLSNPAMRTRHWKQLVRVTGGALTIDNDTLKRMTLRELLSLGLQQHVDDVRAIVQRAVKDLAIENALKTYEEVWLSKVFELRAHVRNKVSVSADITQNLNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4S0</accession>
    <name>A0ABM0K4S0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Transmembrane channel-like protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC101851832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108730.1">
        <property type="nucleotide sequence ID" value="XM_005108673.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005108731.1">
        <property type="nucleotide sequence ID" value="XM_005108674.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101851832"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF43">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="7">
        <location>
            <begin position="497"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005108730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005108731.1"/>
        </source>
    </evidence>
    <sequence length="775" mass="89603" checksum="7C8FAC5684BF7842" modified="2025-10-08" version="1">MSIYTQRIDPVNPHYDDGNNYDSIQLQQVPRHTQPNGQHVGNVRLSTRTTMDGSQPANLEEQELDRAMEELIDQLPSRQLADNGVDFPSRTLRARKSFRGRMGQDDDSLDDDFVENFHQELEEENADLDDIDAAVRTMPTTLSRKRKIMHRLSSRRQKKLSQWKLLKYWIQMAFQRLKHRVRKVSRLFDLWRSHLMTIEGCFGTSVLSYFIFLKWVLLINIPLFLLTFCFLVIPQILYRYYQKVPPGYEGHTEEFTGIELLTGAGFFEDTEMYYGFYTNETVGVVGSSQYQMNYAYLFTCGGYYLFCLIILGYSYLHSYRKYYIEASGTVSLYYFSMVLCGWDYGIVSPEASQLKHKSIFNEFKEYLAGRKSATAPPTRDDVARKWAFRCFAWLVVLALLGASGYVTYTVSVELSIKPKLANTTSIPVVSPLAMPVVISTIQLFVPMIFTLLEGQEQFSKPKYELYVHMFRDMALKATMLAVLVYFWFDIAATELKCWETFVGQEIYRLVMVDLLFTLGYSFFIEFVRKLLSLKWEIIERAEFAIGRHTLELVYSQSLCWLGVFYSPLLPVVVIIKLIIIFYVKRVSVVQNCKPSLKPWRASRTHTIFVGYLFGFFILTSVAVGCGIFLIKPSIECGPYKHRETSYDVIKEMIDNWKADHDVWREVFGFINSPGFVVGLLVLLGMIWYYTRTIMLSHKEMVAQFKKQLQSEGKDKKFLMNLLNQVKVRGRRVSHHRGPTLHKTMETMSSSPSTRGGNKVFVKTVAESVVSASPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5Q0</accession>
    <name>A0ABM0K5Q0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cholinephosphotransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101857604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109346.1">
        <property type="nucleotide sequence ID" value="XM_005109289.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857604"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005109346.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45228" checksum="98FC9B4E93D4CBE5" modified="2025-10-08" version="1">MAVSAGASVIPRKDGFYDKYIRSYQILTQGQLKRLKEHKYSAEGQSVLEPPMQVFWRWTVEQVPLWWAPNAITIIGLIINIVTTLILAFYSPDCVQEAPRWAYFLSGVGLFVYQTLDAIDGKQARRTKSSSPLGELFDHGCDSISTGMVILGASIAMQLGHQTGWLFFENLAAFFLFYVAHWQTYVCGTLKFGKIDVTEGQFAVIGIYFLTALFGPQIWSYQLPVLSLQLKFVPIIFSLFGAALQVSCAFQVIFMQGGVGKNGSTVAGTSTVFPVLPTTVVVLIAVVIQQKSPSLVFENHPCLYLLAFGLLAAKVTNRLVVAHMTKSEMDLWDSGLLGPGALFLNQYFNCVLSEYLVLWLCLTWVLFDILRYSAVVCQEICEFLEIYCFTITSRPNAGGDKKNGSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5V6</accession>
    <name>A0ABM0K5V6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">La-related protein Larp4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101860202</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005109442.1">
        <property type="nucleotide sequence ID" value="XM_005109385.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005109443.1">
        <property type="nucleotide sequence ID" value="XM_005109386.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860202"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF44">
        <property type="entry name" value="PROTEIN BTG3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="435"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005109442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005109443.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="53253" checksum="973A81E12348620D" modified="2025-10-08" version="1">MKPEINAAAEFLSRIFLAHDNISTDKVSEFKQHLSEVLEERFRDHWHESCPTKGQAYRCIRICPDEPLDPVLEKVCTDVGVNHEDFNLPMELTLWVDPLEVVCKFGDLKCSYHTVAKKDQTSGTLDNQTQNLDIDDLVENARDLYLKKQTVVIHPIHSTEMHIPNPYPDGSPGGFTMAIRMNGTMHYNMSSSPPSGYDVSPRGKGKPPHSLWHPHNKRSGSSYHYYGKSSGGKGTFVANGTVNASSHLATGSHSSGSGYQHHRGGGSGHSGHHQHHHHHHHHQNHHGSSNHHHHQHHQQHHHHHAGQGGSGGVSSSSYAYQNGYMNGFPEENGYNSYDHRSTSPTKVNGMPPPPMGSAGNGAGGGPPGQISQNSPTPEQIQQQMQHPPPPPPSSFPPHLQQAFSTHPPATDHSNSLSAPPPPASSQQQPQPPPASSSAVIASSTTTFNSNSSSNNSSSGTTGSGKINNSSKFQGSRGGGGGGGRHGQSPVKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K6Z5</accession>
    <name>A0ABM0K6Z5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC101856297</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7 8" type="primary">LOC101856297</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005110192.1">
        <property type="nucleotide sequence ID" value="XM_005110135.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005110193.1">
        <property type="nucleotide sequence ID" value="XM_005110136.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005110194.1">
        <property type="nucleotide sequence ID" value="XM_005110137.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005110195.1">
        <property type="nucleotide sequence ID" value="XM_005110138.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005110196.1">
        <property type="nucleotide sequence ID" value="XM_005110139.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856297"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF36">
        <property type="entry name" value="TYPE A VON WILLEBRAND FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="164"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005110192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005110193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005110194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005110195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005110196.1"/>
        </source>
    </evidence>
    <sequence length="742" mass="82335" checksum="D4ABFA7A9E6D63EB" modified="2025-10-08" version="1">MDFASGYILEEEEESEEEQDCDEDFVGPECFEDVPQYEQYECEIMEFDDDDAEIPQQQKEKKPKGSSTNTVRLPLKQLKEKSDAVLRDQLKYTCPNPEVCGAILSHIDTPLEKPDSTEKIWKCRFCGEERTIPEWPDFSNGNDIIYCQDPQSPPNLDSDSEENTVIFVLDSSGSMGTPLKPSQMFIRNPLLQLLTGMSGGAPLPMMGNMALTGSGPSSSRDDSKTRLDAMKAGIASQIEKLKATAPKTRVGVVAFNGEVTVFGDGSHKPEVVSEQFYFDYNMLLTVGQQQEPLGHVESNCDNLVKALKGMEEDGRTALGPALVVAMAMASKSKTSKIILCTDGYANVGLGNLESNSEKELESFYSPVSAYCKTQGISVSIISFDKCGIAKALGELPVETGGTLVLIKPDELELPIGDELRRKTMATDAYVKFVVHKQLYIASSDSKVEPKSNHYHLVGILHDEMSQVFTFGFRKDEKSKQERKEKKEQDQTGEETSDKFSSICEPVTDEKEQPADSGERNSSETSQSNLTTEKIRELTDEEVARLAEREDPDAANSPGTKRKRGSEEPTPAPTTNGDDSSSNQEETKEQKEEPVPTDKVDDSRASVTEEFPFQVQICYVDLNGTEAIRVWTNVKPVTGDRQQADEASNMRTRVDNLIQQSAKELFDIYNKKITGVSLLSKTRALQNEINDLLKQKLTTDVSQSLNRYLTILGKIRQTDHIGEVVASELRNFQQGKIIVTNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K7Z7</accession>
    <name>A0ABM0K7Z7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC101864425</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101864425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005110954.2">
        <property type="nucleotide sequence ID" value="XM_005110897.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864425"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005110954.2"/>
        </source>
    </evidence>
    <sequence length="434" mass="47895" checksum="DFD1F0B8BF1C9726" modified="2025-10-08" version="1">MSLFRKSLSEDGVDRYSHLWSVLLLLTLALVTWLLPFSPTISSSYLATQPSEQPLNRLEPPTYHAKCGVPPEFRGSNDDYTNRICASFVNSAYRGEKKNVSLYRLTEDSGPINTSSKERFKPKLMTTSNLGSRSYRQMTSQDASLGPDMYLFLAVTVPLALFLFAVCLKLPLILFRLMSGCGSINVERTLDTARGGLTLDAESRRELNFDLSRAATESAKTSRGVALSYLMFKLLLCVVTLVELVILGSFLMPQLTQLKDRNDNPGLVPGASTQTSPDLHSKAYEFENDMLLICELEIYQLQNVATFNLQCLFSYDEGATADHSRVGAETQGTSDQHLAGDVLNGYHALLTAVLAYLVILLVVNVLSLITWTSKLVFGIFRSSLLQGSSSLSLDLSFLLLMSQENNGPLVTQELAGHLTSATGLDRVMDKRTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K836</accession>
    <name>A0ABM0K836_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized aarF domain-containing protein kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111035.1">
        <property type="nucleotide sequence ID" value="XM_005110978.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864106"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="301"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005111035.1"/>
        </source>
    </evidence>
    <sequence length="620" mass="70278" checksum="1F940DDE9FA1750A" modified="2025-10-08" version="1">MMSPVRRILTSTSFHTGVPSHIQRMLMKTTQLTLRNKVSFIVGNRSSVKIGQRMRVCISSLLLGVPVACISSEMFTKFPFKVFNHLFYVAQCETMDNAVIMVKKDEQFCPSLQERIVERLLLCLRAIHLSVLFFPLLVLYPVSYLHVSCFQLWLSLLYRATERSGATFIKLGQWASTRRDLFSPDFCECFSRLHHRVRPHAWSHTVETLKEAFGSNWRLILGLQEKQEPIGSGCIAQVYKGSIPSSFASSEITKEIRDEDDHQIFYEEGVEVASLPVDSHTDALSTANTNNSDPGTSDVIPVAIKVLHPNIRETFHRDLVLMAATAKYLTKLFPKLHWVNLNQCVQEFSETMNRQLDMRHEARNLQRFTRNFHNVSSIRVPQPIPALVRRNILVETFEEGISVGQVVSDHSYPTELREHLAKLGMDLLMRMVFVDNLVHADLHPGNLLVQNLESFHKEKTAVVEVDALDVMVVDVRPMEESAVRLVLLDCGITTSLEPEDRLKFMEVFTAVVKGDGVAVADLFLSKSAVNHCTDKNLFRTEMSQVVLKGRQNLSSISKIKVAELMHEVFDVLSRHKIQLESSFATIILAIAMLEGLGRSLDPNLDLLQQARPIVLNSAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K895</accession>
    <name>A0ABM0K895_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor E2F8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101849329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005111136.2">
        <property type="nucleotide sequence ID" value="XM_005111079.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849329"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR EFL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="216"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="345"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="732"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="988"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005111136.2"/>
        </source>
    </evidence>
    <sequence length="1038" mass="112962" checksum="ADC6F5BF26646E62" modified="2025-10-08" version="1">MADENATRKLVIVQVGKPMRSNVNSRRMRRCLSDKPQHGRVELSTSTKDAEKENMERKLMCKSQSLTFSKRNLRSRKPLERSETENSQDGFSDVESMGSVDEDMLFDSNNNEGYCTPQKTPRDCEMSNSGSNNEPVSPTWNLKMLCTAVSPEIRRMQQERESVVEEGRSSAASSMTSMTCSGHILSPTEENSREGLDMISSQDSAVGTDLEMFTSRKDKSLGRLCDKFLLKYPDHPGNCRIEICLDEVAKDLAVERRRIYDIVNVLESVEIVSRAAKNKYTWHGKTNLPHTLVKLKILAEKDKLAEQMKKIRDQELARELEDQQPGAKEAKADTEEKVEEAVLPRKDKSLGIMSQKFLMLFLVSKPKTVNLDLSAKILIGDLMDNFDPSKFKTKIRRLYDIANILTSLGLIKKVHVTEIRGRKPAFQYIGPDVDNIHDVNTCCNDGCHRPSSRHSLLDCVRNENVQSIVNGFRPIRPAGTSSLLDGMKVRSDLRVKLQQQTCDGPGSGLNRHSSFDEICRIAEQERNVLIRGSTSVPTSPVKKLNFDEVPAPEPRQPKFAVPAMVKHFSFDERLVKSDGGQPTLKAVHSIPGKVIHRPRAIPAQTQPKNIIICTPTTATRTPDTLIFSQETGEVRSVGSHGNQKHTLSQAEIDHVLHSLRIVKPAAQRQIQFNKPPEEGGSGTASFLGRSLLSPDYDMATLNETSPMPGTTFINRTLKRNMVEVDFGPQGEKRIKLDLPTPPCGSSAVSSSAGGSGLTLSSGVGKTPDVKFSLKRIHSMPPPSTTNSSSSSSSVKTLPHIIVHRRVRPASSSQNTPSPGGQLITLQMSNESSTTTTTTTTHYMSLLGERPCVVKNGSGTTSRIVIENVSTAAAPISSLVKNTPNSSSTPVPIRIIANPHVSVPFSSFSSSSSSSSVVSPALTLSQPSPTPLEAFTPPLTPNSTAAMPTFGSSGPGSVIATTCVGSSVAMSTPHAPVSLRKVLTTMPGSTVQGTASRLPSHSSSSSPFKVVVPSGSKQPATTYLLKVPAQGKLSKTASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K8L7</accession>
    <name>A0ABM0K8L7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855686</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005111400.1">
        <property type="nucleotide sequence ID" value="XM_005111343.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855686"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005111400.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="57966" checksum="6FCAC864E16E2776" modified="2025-10-08" version="1">MSASVLSRAYPDVSSGGPSAPGTPRASSMSLRPPVTAIGLPTSSLRHGDKPRLLGVPGSDLRITFASDTSFVERKGRIRPSSKQTATSLNLRPVQGIERSLKSRARLPKATTPTHGRNTAASYEEHMNPRKALDIARSYGVPKYFLRGNSQILTDGRMRLFGDNVWKKERTSIDSEGKTTDSSDVIHRLMDSVDKAIATADKGPGSSSYSGGDDAGLKLEVISLKSTTEDRASLKESLVSLPDVLQTGSTRSGWDEGGPEVKESDAGYSSGAGEGTMDGLDERAQDVLDGLPQPQHGGFGKKDLGSFRPHTVDTAVSIPRHLPKVTFREPEDRERKDLRLGENEEGDANNFSNVPITPQLAGLRVKHLASTFRTGTADSLTSNKANLFGEKYQNVLPRFYPALSEHRNRQAEAEKSAAANRQAKKKSAQQRLVRFADTHTVRFANEAVHREPISGLVASRAPVQSVQRSLDSHSGLSQSEKLRAKLKEISDYNRARSISVGDRQTQGARRDNSENIEPRKGFLFQLHSSYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9U7</accession>
    <name>A0ABM0K9U7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMRFamide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005112379.1">
        <property type="nucleotide sequence ID" value="XM_005112322.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846181"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="88"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005112379.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="58330" checksum="0C134BBD3E8897EE" modified="2025-10-08" version="1">MNVFMESLAPGPGQYDVNDSLRGEAEAYLGGEDNMTSGILAGTATVGTDGVAVTTAAQQDIDRARANFLKFIVWGIMGSILAALGFLGNTLSMVVLQQRQMRSSTSYYLLSLAIYDNCVLLGMTLYFILPALAPYRPELTDYHSTFALTIPVGYPLSLSAQMGSIYTCVGFTVERFIAVCRPLHVANTCTKSRTLRAILLVFIWAILYNIPRFFHYELEYVTVPEASGAGSVVNATVETLTENTLDIGLQHTGCNTTAIFGGSGWSYNGTGYGPCPPGTEWGAGLEVNSSHDIGSPTAALFTRDLIQDAASDMSRGATLVESAAEAASPSSATPITITTTTSSSSSSSSSTVPPAPKSVIRYSETEFGLDPTFQHIYLIYSHLFFMFLLPFLIILVMNVGLIRAVKRSKSMRQSMSASASKEHNLTVMLIAVIVVFLVCQFPTIVDNILVAMVGEKQLKQHYTYMCFYIICTFMVEINAASNFLLYCFFGKKFRMTFLSILGLKRKQHHVAYRSTVCRSKTNGTRVYDMEVSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA70</accession>
    <name>A0ABM0KA70_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Cytochrome P450 3A24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC101852221</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112640.1">
        <property type="nucleotide sequence ID" value="XM_005112583.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005112641.1">
        <property type="nucleotide sequence ID" value="XM_005112584.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101852221"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005112640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005112641.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="59549" checksum="2F17292F23E781DE" modified="2025-10-08" version="1">MITMEVSALTWTLMCLVLLLLLVYVFYMSSTHMIFRKLGIPGPTPWPVFGNFVAEARAGIMNYQTDLYFKYKHEKVYGFYRGKLAILTIRDLDMIRDICVKNFNDFVNRTTFSNDEPFKNALTEAKDEHWKNIRTTISPTFNTVRLKRMYRHIESNTRQLLDHLKNKQERNEPVELKEVLSHFTMDVIASTGFGVQTNSLGDPNNQFIKESERIMASIGRIFLISTFLDFLKPVLTFFGIASMPRVSLDFFSRFVDVAIQERKLESSGVGSRRHDFLQLMMEAEEDKPGEENDNMTEEEARVLNTHRKSKPGLSLGDMQGQAIIFTLAGYETVSSVLTFTLFLLTMNPECLQKAQAEVDEVLGRKFPDYDDIQSLKYLDMCLNEAIRMFPPGFFLDRKCNADVEIQGVRIPKGVTVLFPMGAIHRDPDLWPEPDKFVPERFTPENKSKRHPYAHLPFGQGPRNCIGMRLALLETKVAVAAILQKFSLVRCEQSKYPVVLEQFRLAPKDGAWVKLEART</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAC0</accession>
    <name>A0ABM0KAC0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase plo1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101856861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112738.1">
        <property type="nucleotide sequence ID" value="XM_005112681.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856861"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005112738.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="49043" checksum="39DBBAE2C7795401" modified="2025-10-08" version="1">MSKMHKLKEPRFKTLDGDALPALDMEEGRTMLRETYKQVHRVNKKGRKLDKFAMINIHNFSFSGESRDGRKRRVDRFRHKVSVLQSLRHTNIVRMSLAVEGPSYKALFTEFLPFALHLYLDEMTGDEPQSCVTQLTDAICYLHTRRIVHGDLKLANVLTDRNSVFKLCGFGSAQVLPRESDKPNSWTGTPEYRAPELDDHSMEQNAFKMESYSFGVLSWCILLGNRPSHLRGYILTTVKRSSRLEPVNRECLTRLLALSPSERATMFQIRDIMERHTLEARPRLLSSASSSSSSETRDASSDISANSSWQSQTTGSSPEQLSPNVSTPGETDNRIPVLIGEREDSCCCEQDPAHTLFSPDFFAEIFEFDPLTLHPVATTGHPIPVLNVSPRSEPPPRDPWNPSISYTGRGLLRHQVEKSNGEITEFPEPWLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAW4</accession>
    <name>A0ABM0KAW4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline-rich protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113177.2">
        <property type="nucleotide sequence ID" value="XM_005113120.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854306"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330">
        <property type="entry name" value="P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330:SF9">
        <property type="entry name" value="PROLINE-RICH PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005113177.2"/>
        </source>
    </evidence>
    <sequence length="316" mass="33722" checksum="17A998A4D8905616" modified="2025-10-08" version="1">MDYVTGWMLDAFNMSKTAARGLLSGLTTSDRLSARIAELEAELKAAKTNQGNAEVRSSSSGLGSLGVYRQHVCAACLKPSYACVTLEGSSVDPEDYIGLFPESSSSSSARLLSSSKSNSGTHSHGPAVSEVSSFVSEKARGKEYAPPNMLVSSTAAPAPPPPPPPPPPPPPPYFMPVIRRLKTDVQTKDQVMKKMRAVGGTLLPEVTVEALRSVKLKRTGGPDLRSRINEDGNLSAKPLAPSNQPVVTLAALQRVSLRKTSHVVKSHGDCVEDDVSRKENENSGDGTMVDIRKVLKRTTLQRSPGGTPMTSKRTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZU82</accession>
    <name>A0ABM0ZU82_APLCA</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847799</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012934562.1">
        <property type="nucleotide sequence ID" value="XM_013079108.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847799"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046372022" evidence="2">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012934562.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21048" checksum="D3CDF628EE6816C6" modified="2025-10-08" version="1">MKNLVPVAAFCFVVLFSAELVSSRWCTRLKSETSVKTFVESAMCNESYEVDCGWFASTKCVQYDSVPCLVKKNRTIIRYKIIEECCKGYELDPINNITCIWIHGEMARISGSEGRIHYYEDDDSLLWGLSHGAYAGIICSFVFIICVAILIGLHMRKRHLRARAKVEEPQKMQEMSEKLMPAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZV05</accession>
    <name>A0ABM0ZV05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">G-protein coupled receptor GRL101-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101846062</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012935010.2">
        <property type="nucleotide sequence ID" value="XM_013079556.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846062"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1107"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1142"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1183"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1228"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1277"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1330"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1363"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="253"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="433"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="1119"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="793"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="800"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="852"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_012935010.2"/>
        </source>
    </evidence>
    <sequence length="1397" mass="156546" checksum="8AF0BE2058D9EA37" modified="2025-10-08" version="1">MCTVTRSRRTSDVKSSWTEKTKYTVSGEHISVTNDLRPSLVYSRQLENNLWSVKQENRETHNFNLGHLLSNVSRDELERVKRQSSAQVNFYKNCQKILDGSTYYSVRGPFYVNTEESIAPFRLQCGSEAGLLITGEEGVIHFRSPCCAAGCTTRFFIDSTSGSEFSMEFLDFNVPSPLMLNSDGSYSCTDSRVFFAFQSIAFCGNIAPKPFKVAPAFVDMRVETRKNMLCRDAISFSLKFRKCDRRDRVVSMCKSQHTVVHEGQSGFITSPGYREGNRYPPYTRCEWDIEVSNNSVIQLSFEFYQISYGIDSVSISTKGHPHTDQHHAVDVSFFQADYRVKDGYFLTLPSYRAKVAFFTDRYSHGKGFKMWYTAASKDSYIPVIDKFVLNCSGHELSLPLHILCDFRDDCDGREDEAKCTYVNETWCPDGHVFGTSCYHLQAPHSTVTWQKAEDICMQQYNGHLVTPNSKEELKFISDLIIVKYPVSTPWYLGFRHSSFGADLLYRKLYQSLDGTTIFNGFIQQFVSDISATCAAWDYMTELNQREVANIPCFEIWTKIEYDVIRSTSSFQQQNVHIACEVRRASEVKPILASSPTVVWASKREMFECVASKERVSMSRRCDWVSDCFDGSDEVDCAGLSGTPLYRRFTCTSGRLLWYSHVCDGVSDCSDGSDEEFCSPVPVDNNDLTVCANGIPVPSSSWCDAKPDCLDASDELDCSRCNGGAILCPSVGCLPPHWAHDDALDCHARDQSGQWILEPDFVPHTVQAQPPPGVVMPDGYGKVTILPLDEGDPCPPTHVQCPKGYCVPIYMLCNGHKDCPEGEDELAETCQSFCKGRFKCHQTSMCLHDDHVCDGWFHCPLHDDERFCFANDTCPLGCACSGEEMTCNSGSMISDLGRVRRLDISYITLQNDLLTIQNHYLISLFAHNSSIRQLGHLGMVNLYHLDLSDNYLRKLSLDTFEKTQGIRQLSLARNELTDVDLQPITSLKNLEILDLSGNVQVRIKSYSFTGLSKLTTLHLDDMGIAVVEHNAFDGLEKLGTLTMKGNSMSVFQKSVLLGLSQLSSLSSDNYKLCCPIMKPESLSKGTCQAPKDEISSCEDILRTSFLRVFLWLMASLTILGNSCVLVYRFCVDRKPSTLGFNTFITNLSASDLLMGMYLAIIGAADQVYRGRYLWEAETWKNSSYCSLAGFLCMVSSEVSAFTICMVTLDRYLALAFPLANVHLTPKRARLVQMVTWVVGVLFAGIPLLPSLSHWRFYSQNGICVPLPITRASFPGSNYAFAIFIMLNFVIFVSIAVGQILIFRSVRANSTKMKGATTANRRNQDTAIAQKLALVVITDFLCWFPIGVMGLLSKTSVPIPGEANVVATIFILPLNSALNPYLYTLSGVRQKLQQKSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXJ8</accession>
    <name>A0ABM0ZXJ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FYVE, RhoGEF and PH domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101850160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936562.2">
        <property type="nucleotide sequence ID" value="XM_013081108.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850160"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13389">
        <property type="entry name" value="PH1_FGD5_FGD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF267">
        <property type="entry name" value="PROTEIN CBG10230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1453"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1671"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1351"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012936562.2"/>
        </source>
    </evidence>
    <sequence length="1818" mass="194540" checksum="B669D44633989729" modified="2025-10-08" version="1">MEKPRPQLPAKPPVAAKPRRKPPAPPPPPKPTLVSTSLSPSPSSVQLSSPNGDVAGKESLAVDNQPENHSSSVPNGPSGSNERADGVQDPHKGLESSDRETEPIKVDPPPLPSSPPPTQRKGPLSPSSNPSLSPFSSSSSTPQQKVENDTESNLLDNPLPASANEACTVSPSTTLSNPKLPSPQPPPKSKSPSVPVKAPPPVRPKPKPLTIPPPDTSASNVESKSDEPQSKDESSGSSRTESDCSVSKAENLTDETQDKGNVSVSKAENLTDETQDKGNVSVSKAENLTDETQDKGNVSVSKAENLTDETQDKGNVSVSKAENLTDETQDKGNVSVSKAENLTDETQDKGNVSVSKDTNAEPDTSKMVGVSKEAHANPDTSKTVDESPLLNSRKIASALEEVLKKSPPKVPAKKPVNPPARPTSPPARPAPPPSRPAPPPSRPTPPPKRAPPPPKRPSLPHVTPATPTAVSSPSPQPSPATTTVPAGSCQVASEVQVEAETDPVSKKAAKPSVPPPLPSTPPPLPSAPPPLPKNPPRGGVPRKPRSQSNVSKNSLKEASVSATEKSSYKEGEGSEGKASSEGKASSATSSPEKGGKKVCEHSQDLSLPKEKGSDEAQPLDIATDQSQKPERTLKKQQAFDSSDSNSNTPVLRDKSGTLPHSEENDLKNSDLNQESLPRPVPRKRLSIPAVPKTDEDPNVSQKSTSVVEKKNGKSAVDSNTSAAKTASKKQFLLKIDPELDYAEVYCGSDDDGLGDEGESQSSVSAEKTTSASKQVDVCQDSQSAKSITNASGELSEEPKGVGCVGDSKGKDGVSDDGASEGPKLSLSDEPGSTCEMLKEIEELLKNKLGGDFETDLEGGVDSETTKPESDSEGKTTLQEVEDSPKWRANSLDSSSPVRPPRPKRHASISRLRGSVESLDQAVVDSSSVECLHTASGQSSSGKKVVPPKPKRTTLPRINRSRSDVTGMKAVADGAEENSNSSDTAAGDQEGSDLKPYLPPRLESLRRSESCSNNSVPPPLPPRNKPRSTSMNESGRAMSSISLSSAASTSTLDVTVSPSASSSALTPNDAKSAIPPSGRKDGATPKTPQKRASRATAKPRPVRKAPPPPPGPPKRAATFAPGDTKAQSGSEKSEESSSGASDGKSDQRKGSRSPPQPSVKKTLSMMRRRSQSPGEDHDYHEIPDSSVVADARRQEDQSKERETTPPPPQLPPRSHRASSRVSADVSLTSDDKKETQESQSASEQPTRGGVGGMAEEEAKQEDDGKSGNSPEDQKRKAKRAKAALIQKVSQDLGLPRSPAPPADGDAGALRFENPSFELEGQVAGGVAGDEEDDSAADGGSKTGEEDSTNAEEGGKNAEEGRKTAADEDQNTAAEEDSETTADGEQAKEVRHKSVSDASSSPSSPKRDRPESMASHQSTGSEQEGEGHLEDIASSESESDEDGSEEIYAQRKALKVFYIAEEIMTSEKSFVDVLKLLNIDFRKHISTATEKQGQPVIPTETLNKILDYLPQLQNFNEELLKDLTERINNWENNKRLSDIFVKKGPFLKLYSSYIRNFENATAILDDSCKKNPAFAAALKEFEMSPRCASLALKHYMLKPIQRIPQYKLLLQDYMKQLYTDSPDYKDTTTALNIVSEVADHANESMRHGDNVQKLLEIQRSLIGQFEVIEPGRELIKKGELQKLSRKEMQPRMFFLFSDVLLYTTPATGGYKVNNVLPLSGMKIVRPKLEDYKFEFNILSTQRSFTVCASTSQEKEDWISALQEAVEENAKRFHTFECVKHGQTSLHDKDFVLGAKAPLWVPDARVTMCMLCLSEFTITWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXR4</accession>
    <name>A0ABM0ZXR4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rabankyrin-5 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101854943</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936670.2">
        <property type="nucleotide sequence ID" value="XM_013081216.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854943"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18501">
        <property type="entry name" value="BACK_ANKFY1_Rank5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18303">
        <property type="entry name" value="BTB_POZ_Rank-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15728">
        <property type="entry name" value="FYVE_ANFY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049765">
        <property type="entry name" value="ANFY1_BTB_POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049764">
        <property type="entry name" value="ANFY1_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049763">
        <property type="entry name" value="ANKFY1_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF191">
        <property type="entry name" value="RABANKYRIN-5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="689"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="771"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="804"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="872"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="907"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="940"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012936670.2"/>
        </source>
    </evidence>
    <sequence length="1189" mass="130622" checksum="851A074C9C34ADD6" modified="2025-10-08" version="1">MIKLANMADDEVSKLQNHLSLLREEYVKLQNRLADVERRYQVAIAASGGTGEAQDGFVSRLLKFIADLFDKDQYSDLVIQLEGGHDVKAHKFILSARSDDWGVADLSTVAELNMTDIRHDVAFALIRWIYTDEINIKAQDSFLLELLRAATRFKLEELRNRCENGLMSFVNVKNCIKFYQTAEEMQAEVLKKHCSELISNHWDQFTREDFVSMPAPLLYKMFKTKTEYPLHTAIRTEREDVVFLYLIEFDAQLSVKVNEVDNKGELALDLALKTQQRSIAQTLMANKADVNRKDNSGKCLLYKAIQRGDEFAAEFLITNGCDVNMATHLDKETPLHMVSRFDPKVTDTGVIQGMAKVAKLLVDHKADVNVQDSTGCTPLHNAVLSCNEPVFSVLTSCGRVDLEIKNSEGHTVLWLALQRQAESPVEENGPLYGEKTLAAQLITAGASPDAVEPETGNSLLHLAAQHGYQEAGIFLADHRASVGLANFKGETPLHYACEEGLTELVRILLEKGANPNAQTVRTPTSTINMAALGYGEDENAEISQQTPLHLALTKGHHSVVQVFLDHKAQLSKSGATGTKVLPNFNVKDSRGQTVLALSLWNNMHDMADKLLACGANINEKNSAGMTLLHQAIEAQDAPSALFLMDHLADLESISPDKQTVLQHAISRHLPVVVSALCERGVNMDTLDEQGDCPLWQALDSGQEEIAHTLVKHGCDVNLWSQSPVGCFQTLLHRALDQNNEAIASFLIRSGCDKNCPRRPGPNGEGAEEGSDGQTPLHMACAWGLEMVVQCLMEHSADVNAQDAEGKTPVHIAIENQFPVVISLLLSHPGLDLKARDKRGHSPFAAAMLTKDNKAAQAILSREPTAAEQVDNKGRNFLHTAITKADIESVLFLLSVHANVNSRSQDSQNLTPLHLAVLASSEIIVRNLLLAGALVNERTKTCETALHLAAAKDCSTICSILLDNSVDFDAVDENLNNALHRAVINGNLNTVKVLLTESTINAEAVNAKGQNPLHILGQYGKDNAAAMFELFRDTMPEYPIDRPDNEGNTVILLAYLNGNGNLCRALVRAGACLGCVNKQGLSIFNAPVATKQLLFKLLDMLSKDVTLIHVLISLLSDMLSKEPPWSEGESCLECSAKFNIKTRKHHCRHCGRLLCSKCSSRDMPIVKFNLSKPVRVCDVCFDVLSVGGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A090</accession>
    <name>A0ABM1A090_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862729</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938190.1">
        <property type="nucleotide sequence ID" value="XM_013082736.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862729"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938190.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11352" checksum="B7D613D9B272FE8E" modified="2025-10-08" version="1">MHGAGQLKQIVNEVTDAFSPEENAHTGEQDGTDIKVRVQETVGKTCDSMTRVDGPSNTPSETSDLSASYLLTGPEAEGERSSADSVKGIRLCFHDEKMENIENPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0Q9</accession>
    <name>A0ABM1A0Q9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chitotriosidase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101859411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938466.1">
        <property type="nucleotide sequence ID" value="XM_013083012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859411"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="110"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012938466.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="50861" checksum="69BADA8C2139A9F4" modified="2025-10-08" version="1">GGGTTGSGGSGGGGTTGSGGSDGSGSGSGGGGSTGTGNGGGGSTGSGGNNDGGTTNGGGDNTGGGGGSTTGGGSGNNGGGTTGGGGSTGGTAKIPGVPIFSPRAPNDTCKRVVCYYTNWAQYRPGIGQYFPENINASHCTHIVYAFAKLDSQNRLMPYEWNDDSTEWKKGMYERMMKLKVENPNLKILLAVGGWTMSSPPFARMVATPQTRQTFISTSITFLRDRSFDGLDLDWEYPGDRGSPPEDKGRFSLLLKETLDAYKEEAALTGKPRLLLTAAVAAGKTAVDKAYEIPELAKYLDFLNLMSYDLHGAWERSTGHNSPLHKGSHEWGLSAQLNVEWAVNYWINGGYPADRLVVGVPFYGRSFTLSGSNSGLGASARGAGTAGKYTREAGFLAFYEICEYLKDQASVVTRVDEMGVPYVVKGNQWVGYDDTTSLARKVNYILDNKLGGVMLWSLAMDDFSNSSCGLGNYPLLTTILRTCGVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A0S5</accession>
    <name>A0ABM1A0S5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">All-trans retinoic acid-induced differentiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101864623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938490.1">
        <property type="nucleotide sequence ID" value="XM_013083036.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864623"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042350">
        <property type="entry name" value="ATRAID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15926">
        <property type="entry name" value="ALL-TRANS RETINOIC ACID-INDUCED DIFFERENTIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15926:SF1">
        <property type="entry name" value="ALL-TRANS RETINOIC ACID-INDUCED DIFFERENTIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046453806" evidence="3">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="170"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012938490.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27945" checksum="9B915DB148BA2006" modified="2025-10-08" version="1">MNRWRLGTRMSPVVFLMAVISLVVVKSDRIHQEHGDIENVDSVPAVCSRACKEVSINGTATDLFCKKHPELRVVGRCCLNETEHATLVLGLDLHDCNLTEGSLRSAVVDLNRLMYLSLEANPIQNVTEADLTKNTDIMYLCLPPDIPCPGGQDAWRSEDLINNVRICREELNPCKYRNVSCPENSHCVQLGFSLTECLCNEGFHGYKCMNEGTFPTMAFIAGVSIPTVLISIFLWVTQRRYVVRVTKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1D4</accession>
    <name>A0ABM1A1D4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein DDB_G0283697</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101851194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012938854.2">
        <property type="nucleotide sequence ID" value="XM_013083400.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851194"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF40">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047433420" evidence="8">
        <location>
            <begin position="17"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="9">
        <location>
            <begin position="60"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1124"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="965"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1031"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1140"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012938854.2"/>
        </source>
    </evidence>
    <sequence length="1172" mass="129023" checksum="7BD61EC88514545B" modified="2025-10-08" version="1">MSLILSTFIITVLSTSKNDTLPGNTQTSDVTGSKTNSDLNLTSQAGCTEQAKSSSSAGLCWETMIGQEVVKLTIMDTVFVIGQIIIIDVVRTFFIKYCNKLCCWDLEKTFPEYPDFKTAENLLHLIGNQGVIWLGAFFAPGLPVLNLLKLLLLVYVRCWSVMMFNAPQQRIFRASRSNNFYYALLLIMLFLCMLPPLFAIVGMEPSPDCGPFSGQEKMYNILTTTMEKELPSVINSVLTYAASPGVILPLFMLLGMTIYYLIAVSRSLQDANNELRMQLEYERTEGRRKVYAMADARHEAKENAKPRGWAAAKAKFVGSSGDSKVANTALSLLEMVKSKKPAAKGLDGFKDLATRGASQQDKSKKTAQAVVNRMKSSKGPAVPVAVIRGKQSIKAKERSRQNAKVPFKDLILDYSRKQQKEDAQPNDEKTKGQGGKKGRGNRGPKKEASKGRYRQRREKSHNRRRVSNSSDDDPDYDDNSDDQSSEEDIVQVHRSRSSGTNSSDNDHHGDDDTNGDRDNKGRRSRNLRDAMKSHNSQLDNKVTKEGSVPSGNSRDRGAPSNGNGRDRTKQNVPSHSRSRGNVGNSESGSEDPEENSPKQKRIGGRGEGGQQQRERERMQEKQKSRARKPQMTRQNSYTDKSGHLRPYDDDEEEEGDNEDTHNSDETDSEEGDAVDHNNGKRVNDSSRGNKATSGRLEKASKGGSSKSNGGREKQSSETNSKVPQPPPKLTKRREQNQSIPPLSNIDRQPFTGASSSKSKRKVAVPKDKNKQPTEIEIIDEVADDSKTNRQQKRKPKKSEQRKGSETSLTGPVPEIRVEDFSENGNSTGSSSNKDKGVNRDNVLKPNTKGGKPKVSPKQEGANKEQLNKKTDKDDRSRGAVRKLSFMFENKAGGNSSATPDVEGEEINTEVEVSPRSGEEESAGVEKNRATDDGSDVSENSYPSTSRDATRNAERDSETQGTSASKDNRPHDVDFGNRRKTRDRRARLSPGDEPSGPAADTDTDVLIDIGQDDEEDIAMATTPSGDPGVNSFRERSSSYGQYRRDRPSVISLGLAEEDVERLSTGGDDVTGRNPTPPGVSAHNAGTPLERKPEVERRSSNGGFAILAITNGNLDIDTEGELDIINNTERQNDNEEQGGGYTDSQTSNKNNPSTGRKILKATGFSNLLKKFQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A1J9</accession>
    <name>A0ABM1A1J9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trigger factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012938962.1">
        <property type="nucleotide sequence ID" value="XM_013083508.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101864151"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012938962.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24779" checksum="1A6AC3F64E438EBE" modified="2025-10-08" version="1">MAFSVSYKSMTDRDIKYTYSDQKISFVYPHRTSFRPLKEERPLPPLKKYPRRFYEYYPRFHIGIPRAPAFRGTDPDRVDRIVARICKPIECQKARRRDIQPEQTTHHVDNDNDDHDDDEDDDDDNNNNDDDANKNSRGSDTHRSDASNTSSRFTAKDISELTARLQKPTESSRQKAYLQRRQEDDREEANRSEIPPLAHVRRLPPISRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4I9</accession>
    <name>A0ABM1A4I9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC106012386</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106012386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940699.1">
        <property type="nucleotide sequence ID" value="XM_013085245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012386"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046253294" evidence="4">
        <location>
            <begin position="29"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012940699.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30413" checksum="C2DE46F652791DEA" modified="2025-10-08" version="1">MTFMNSTLLNTWIFVLNCFIVIMCNVHAEPQHVFLEEHCGNELSTDASILLVVGNWSSLPVDHSCYISFRLQTHFHSKDVARGQVSVLSVSLPGPPCTQGRVDVISSDNVTLLSEPGGICGSTFKGKFASSHDLVFINVTSEDKEVWGYLDILISSFNTDVCDTSHEFACDNGRCVSASVQCDGYDDCGDDSDETDGCLMSTLVIVVIVCVSAFVVIVVVIVLVLAVKRRWRMQGWGTGPTTSSLIGSINEDSEDVTTQKPIHYYTSKDSYGTMTTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5Q2</accession>
    <name>A0ABM1A5Q2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microtubule-associated protein futsch</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941332.2">
        <property type="nucleotide sequence ID" value="XM_013085878.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012564"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941332.2"/>
        </source>
    </evidence>
    <sequence length="616" mass="67080" checksum="7903F70D2184314C" modified="2025-10-08" version="1">MTGLNPATPPDSAEGQERKTAQTFHEKVGSLRDMVERVREEKRKKKAERKINNCAPTNDAPESENEAAKDSAQAKQNIPDSCQSVEKEKTETNDGDVNEENNAENIQRGSAFTEKASSKSEDVANAFNCLSEKDTNLTVPMTDHHEKTDDDLEQTRNNFREKSNVIEQNICKDKENVNDIERDFHGYHERCGDKKLEMAEVSPTNPSDKAISRPGVTGPTGEDSDQPSTDTLGNHPFSVTSNRTAASLPVGPTDVIGQPDASVLKRHVPDTSGQKTSIYGEAADQVSTGHVHTSTSRDVTQSQLPAGERGQLSPLDSGLPSNVARVCHVSMAQNKEAPIPDEVNITDCRGASSTATIPHNPDTRNTYATECVSTIAPGPLNPDTSINRENESLKRTRVDSVPTLSSPKHGVTRNIYEKEKSSPDGKKIKAELAKCNKVLKKCNEELAKCNEKLTGQSAKYNKKLTEQNNKSESMVPTEPSSGAQNSVVVKSEISKGLEDGEAELYPEKTNSGDPRAQAANCSALSSGLNHNVFVSEVNQESNSAGCFSLSGGADSTPTEAQRRAEGDSEDEEKPNLITETKESESTSSCKGRKKWKRTQYSKRDQNILKSYFITTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6W4</accession>
    <name>A0ABM1A6W4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 76A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101846678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942000.2">
        <property type="nucleotide sequence ID" value="XM_013086546.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101846678"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012942000.2"/>
        </source>
    </evidence>
    <sequence length="386" mass="44586" checksum="9885E21D14AFBB48" modified="2025-10-08" version="1">MDVCCLCTTWTLAVGAAMLCVLYVLSKQFVFRKGNPPPGPRGWKGFMEILQANRDDSLYEAAWGWAEKYGDLTFYTVLGKPMCMLHSADIVRRVFGSDEYKLLTSDREPTVVSEFAWYNGKELFFTPYNSQTRQKRTLFHKIMGIYGEGVDKFESVVSKELDRVLEEMDTARVTDQDIPMPQILSRSLKIILYVLVNCDIDPARLSIDVTDTLERYDIAVNRMLDVQTLTALTFFPPLRKVGKYKKICDDVTESKIEAEKIMFEDLKFLANSWLFHHDPKIWDDPWKFKPERFLDESGVILPANHPVRKKILPFGHGIRMCPGEAFARSRVFLFVVSILQKFDLFPPENEPLPSCDPRDNLKGVIRQAPPFKCRLRNRREAETSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAM5</accession>
    <name>A0ABM1AAM5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101861395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944054.1">
        <property type="nucleotide sequence ID" value="XM_013088600.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861395"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053880">
        <property type="entry name" value="GPR180-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF24">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21892">
        <property type="entry name" value="TMEM145_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047198789" evidence="8">
        <location>
            <begin position="20"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180-like N-terminal" evidence="10">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180/TMEM145 transmembrane" evidence="9">
        <location>
            <begin position="189"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="621"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="555"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012944054.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="73852" checksum="81D96E194B990D21" modified="2025-10-08" version="1">MRIAGIVWFIVATLPQALAKWREGVIDTDRDWAFLTRFCFLTQQGSLSYDFKYPVGYGTQEILMYYDDPGQWDSIYKRGKNCTQKMSVLSITSNQILALNTSVTQTSKYAGCTLFNQGGDTWYHCVGQRTFRSSRERWWYIAVARCGPPKDLVTGLYLEFKVHMTNGDDLLHKEFSADEFYILPVDIVFFIIYLVMLAMSVVCAVVLRSRQLFHTTYKMYMFALVLWQLHLFLMVVAWCYYGVTGWEEAPVEVTGRVLRAASNTIFILLLILMAKGYTITRGRLPISSTIKITVFMSVYAVIISVLFIWEGLLFDPGKVLYYYESPPGYGLIAMQLIAWLWFLYSLVFTLKHCSSKTRFYIPFFSFYTVWFWASPVVTLVAMFAMAKWSREKTVNGVEQFVGFVGHTFFLFLTRPSAANGNFPYHVRTTQIATMGGEEHLDGNPYTVSSRDGLSGSGPNLEFFITSKEVDNEDTMDGESRVIFSVSGQRGNPPSYNDPPPAYPQVVERPGVASSSSVGGSGDASTVHTTGAGPDHPVSSAGSVQHIHNYGGVIINSVNNNNNNNNVNNNMNNNNNNSNNSNSLVSNVNSNFQARNAFVPPILSGLPPSAGRWALPPLVRGSVLTGHVPSAPPMDPVEETEQPPENFEGTSSKNKKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABC0</accession>
    <name>A0ABM1ABC0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell number regulator 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101859821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944433.1">
        <property type="nucleotide sequence ID" value="XM_013088979.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859821"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045939514" evidence="2">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012944433.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11667" checksum="06FF0D9B8FC98F43" modified="2025-10-08" version="1">MTWQHGLFGCFDNIGLCLIAYFVPCYQLGKNAEKVGDNCLLCGLSFLLPPANVVAQFIVRGKIREMKGIEGTVVEDLLIVFCCTCCALVQEAQELEEPSAAYVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ABQ2</accession>
    <name>A0ABM1ABQ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">17-beta-hydroxysteroid dehydrogenase 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101854368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012944655.1">
        <property type="nucleotide sequence ID" value="XM_013089201.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101854368"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012944655.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="32892" checksum="08992F795ABB36C5" modified="2025-10-08" version="1">MALVGALVELFTTLVVILYNYMVAAYCLFVPPARKPIHGEIVLITGAGHGIGREFALQLSQLGAVTVLWDINKENNEKTAAEVRSGGGQAYTYVCDVRSYEDVARAAREVRRDVGDVSILVNNAGVLNGGSLLDVTEADIRRTFDVNTLAHFWTVKEFLPPMIAKQTGHIFNVVSIAGFSGTALLVDYCASKYAALGFCESLREELVLAGHKGIHVSALCPYFVTTGLVQKFEDKLQAARNAHDTVVTAVDGLLRNQQLIFSPPSMWLSTRIGLLFPRTTNQYMKLKAGASIYEQYSKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACJ5</accession>
    <name>A0ABM1ACJ5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sortilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101860057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012945105.2">
        <property type="nucleotide sequence ID" value="XM_013089651.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860057"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF23">
        <property type="entry name" value="SORTILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046843762" evidence="5">
        <location>
            <begin position="31"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="6">
        <location>
            <begin position="135"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012945105.2"/>
        </source>
    </evidence>
    <sequence length="629" mass="71738" checksum="E1B8BEF430DB7DEB" modified="2025-10-08" version="1">MEVTKRRPLFTSLVAFVILSISLWSGYCSAADHVTSFQQSVSDVESESHSDQGSFLRLLRKRRDAVPDDVTTTESEKYDQRCLNQKEKFSELRNSIKAGQRLEETYTFLNESKFNLALAWAGVDDDGTLLILTTDRQHMMAAVSTLWRSTDNGRSWKNWNDHVDNNIFRQSDGLQRNPHNPKKVYLIGYEHFLYVTEDGGEKWHKSDLVHDDEGQKLTAIDEQLEFHPESDYEDYVMVTSNDRKLYVTYDNFQSKMEESIKSDVHIVKWGTKEQGKAKSIFATTGEYKNPLLSTGPALLDLERYDSERKIWEKIQSKVSMFDVQGKFIYASVYKSDKPKNEEDEKLMMISSDGGESWNEAQLPTLIGDRFYSVLDMSEGLIFMHVDNPGDTGHGVLYTSWENGIVYSESLPNHLFPNYNTVHDFYKIKSIRGVYLASQMSYDKSIHTVITYNLGGEWKNVSRPIGVPCENSEEEGCFLQIHNAYSIHRGIKARLPHSLDKAYGLVLVHGHVASNLQTTDPDVYMSTDGGYNFRMVLKGPHAYEIADSGGLVVAVPLNDPYPKTIKFSTDEGNCWHVYKFTDQEIKFTGLLTEPGGKSLTISVWGYLKDTKKWTLNVIDFGKVVTKHCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADK6</accession>
    <name>A0ABM1ADK6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrophage-expressed gene 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945642.1">
        <property type="nucleotide sequence ID" value="XM_013090188.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861925"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22579">
        <property type="entry name" value="MPEG1_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039707">
        <property type="entry name" value="MPEG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31463">
        <property type="entry name" value="MACROPHAGE-EXPRESSED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31463:SF1">
        <property type="entry name" value="MACROPHAGE-EXPRESSED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="720"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="3">
        <location>
            <begin position="40"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945642.1"/>
        </source>
    </evidence>
    <sequence length="783" mass="85786" checksum="268A3F98FF99ADA5" modified="2025-10-08" version="1">MNYFLLMRLETERQRTTMGQSIVPLVTVAMILAGLHDVTAQGAPYSPAGDVRNCLSDTSRDVNRFEVLPGSGWDNLRNEQAGMVVALNYSQCRTTDDGRYVIPDFVNVYPVKTSRIDSYAEVINKWTEYVSSTSKDINADAGFHGNSFGISGSFSDDYTHVKTRQLEDDTLTTRVQARYVRYRAVLQPDMPLDPGFKYRLLSIAGALELDNQRQARFESQQLVREFGTHVSTGVDAGAAIIQEEQIKTDIKNHSSYSETALKVAAGFSFSTNIGSLFLGASQATVDAKSFAAYYLDNRTDSLVRAMGGNIVNKTNTTIEDWVKEMSNDLVAIGRSGEPIFNFINAQTVPEVPASTLLELVDMVRESVFTYYKVNTHPGCTDRTAQNFSPRANIDDGSCVPPARTTNLGGVYQTCNHTQVDAGDLCTHLTQRNPATGDFSCPTGYEAVPLYSGTKTREQVAHVCGSCWLIFGHCCHDESRTSSANYETFWCALTDPELTPSGYMFGGAYTPHLVNPVTSSMTCPHGYLALLLGENVRVCVSDQYSEAVENQLPFAGFFSCSTGNPLALGSVNSSLTAHMYSEGPESWPRRCPKGYSQFTTEIMPGDGCEVNHCVQAGALSNLKLPALKRPPFLHAPTGTPATQNVFAFDPSQNLWLKNGEAMAKNKSQRPQLAQGRFWAPPPRRHDSQKKEVEFVYVQEGASPAHKKEGGGVKGAEDNTMLLLNIVVLVVLIVVLSLALIVVLVKQRRGGKGQVSKYQKLSPGSEGHENHVTLSEISVDGKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADR5</accession>
    <name>A0ABM1ADR5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Unconventional myosin-Va</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101851317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945738.1">
        <property type="nucleotide sequence ID" value="XM_013090284.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851317"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="49"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012945738.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15180" checksum="26A30D71D4122499" modified="2025-10-08" version="1">MVTVSFRVSLCFPQLRSVVCHRPLYEDTEGVVKVTEKSLPHLRNPDILIGENDLTSLSYLNEPEVLYNLKVRFVEQNLIYTYCGIVLVAINPYEYLDIYSHDIIQAYSGQDMGSMDPHIFAVSEEAFKQMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AE36</accession>
    <name>A0ABM1AE36_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101859746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945937.1">
        <property type="nucleotide sequence ID" value="XM_013090483.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859746"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058796">
        <property type="entry name" value="COPS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25983">
        <property type="entry name" value="COPS2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="258"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012945937.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="52241" checksum="C72A81D602CD55BD" modified="2025-10-08" version="1">MSDDEFMCGDDEEEYDLVYSEESNSEPDVDLENQYYNSKALKEDDPKAALESFQKVLELEGKEKGEWGFKALKQMIKINFRLGNYDEMMVRYKLLLTYIKSAVTRNYSEKSINSILDYISTSKQPVLQMELLQDFYETTLDALKEAKNERLWFKTNTKLGKLYYDRGDYPRLQRILKQLHQSCQTDDGADDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEYEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQETKPYKNDPEILAMTNLVSAYQNNDINDFEKILKTNRQNIMEDPFIREHIEDLLRNIRTQVLIKLIKPYTRIHIPFISRELNIDALEVENLLVSCILDSSVNGRIDQVNQVLELDRESRGTARYNAIDKWTSQVQSLHHAVVNKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEB3</accession>
    <name>A0ABM1AEB3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Dystrophin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101851170</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946043.2">
        <property type="nucleotide sequence ID" value="XM_013090589.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851170"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21186">
        <property type="entry name" value="CH_DMD-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16242">
        <property type="entry name" value="EFh_DMD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035436">
        <property type="entry name" value="Dystrophin/utrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002341">
        <property type="entry name" value="Dystrophin/utrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="17">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="17">
        <location>
            <begin position="143"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="3137"/>
            <end position="3170"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="18">
        <location>
            <begin position="3391"/>
            <end position="3447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3484"/>
            <end position="3503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3772"/>
            <end position="3825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="456"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="937"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1090"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1300"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1373"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1614"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1694"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1786"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2097"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3654"/>
            <end position="3691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3715"/>
            <end position="3759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="3490"/>
            <end position="3503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="3772"/>
            <end position="3789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="3801"/>
            <end position="3815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012946043.2"/>
        </source>
    </evidence>
    <sequence length="3887" mass="444161" checksum="8FA9CE014D2A88AC" modified="2025-10-08" version="1">MENYYSKDLTLLKFKKGRDEREDIQRKTFTKWINSQFSKAQRATITDLFLDLRDGQRLLSLLEVLSGLSLKPEKGKLRVHHINNLNRAMEILENNYSIKLVNISSGDIVDGNQKLTLGLVWSIILNFQVKDVMRNVMEDLGQTNLERTLLSWCQLSTQGYERVDITNFTTSWRDGLAFNALLHHYRPDLFKYKDLQNRDNLYRLNHAFQIASDKLGIDRLLDAEDMTVEVPDKKSVMTYLMCMFQVLPHANLASRANSSGISDVVVSPPVSRKISAEVDIGHVTPRDKGNNLSESAMSMSSSESRHSTMSTVSVDLLSYQDSLENVLTWLLEAEDIMDKQLPIADDVTKVKEQFNQHEEFMVELTRHQDSIGGVLKEGNDLLTEAKVTAEEDKEIRTQMSLLNNRWEELRVKALDRQSRLQKVLMDLQQSQLDALAAWLTDMEQRISQQQAIGAHLDAIKAQVEEHKVIQKSIEEEQRKVDSLQNMVVVVDDNNTESACAAMESQLESLGKRWAQICRWTEEQWLLLQELLMRWQQFSDEQDKFSLWLTQKEAILQRMRSAKLETAEEVITQVKYLKSIENDMVEQVRRFDALNECGQQIVAVVDNQEAIAKISTLLEEFQERWEKLVQDMEAQSKEIANSGVELSKVSDYYEEDVIEAESAKVTSASPPSSTKKRRVESASRSEFDLELKTLLDWMDRTESTLLLLVSDNPSEPFTVEEQRVLIQDTESTVRSHQIDVQRLLTLGQTILTELKIAGESQDAMTVVIKGLEERWEKLNDNLAETQTKVDLNFETKKFYEEMSALQDLMNTYVKWISSAENIAKDAPEITRQLDQCKVKVKAMQSHQDRIDRLRIFGEQIVRQYSAAHTVKPDMEELLAKWQATAGKLDERQKQLLEALDKVPPRTYLETMAVLSKWVKDIDKVIKGDKVQVASVSVMSSQLETFKELSKEMREHEKSLDYLNKTGRDLISKSTEDQAKTLQTDLDRLNAEWAAVATSIEQRQSRLDKSVANVTEFRHQMDGLNKWMREMDVFLHAPDPSVGDIPALQAQLQESKGVQDDVKTLQTNVKSVNALWKNVLSDAEPKFKSEVEEEVKEMNERWEKLVHLAEKQNLRLEASLKKGRTIYDRIEALNMWLTELKDDLANKDYSVENPNDLQVKARKFKTLKSDLEVKSAEMEDITNEAKDILSDSPSGSLQDLARLQMRMNALWDDVNARVDRYHTLYESADRKWKDMRDLLNVESQYLQSLESKVRRTSTASSDAEDISEELNDVETYLAEHSTENKRHISELANDLIHNSIMVETVRKELEDFLRKNEKVESEARSKIQRLEQSIQRAQTIERQMLEMSQWMGDVSQLLQNRLDADMLAGDVPQEHETLQLEVKQQQELLEELEKNVQEYRQQGKMEASARLEQQTQLLKKHFAEVMVKFRKFQRPAEFEPKMTHVWRELGAIQGTVHLLEVPSDEPEAIQERHENCMKFYRTMSELKPEVETVLKTGRQIVEHKQVDFPDCLSKQLDAIKQLYNELGAQIKQSKAALEKSLKLSKKLRKELAAVQEFIDTSNKTLEDREDKGETNVDEELRYIVASQEEVVQKEAALASVHDLIHQLQDLSDEVDVRESRDHARQLTQDMHELSQRLVKHKTKVQENTLALETQFVDFQTQIMKIKEWLGRAETIVGAHSRLSEQQQRLTPHRETIKTMQKQMNDLRSQVDEIRDQAIDLMSKSDCYNRMVEPELSHINQRWEELSQKIRERQASLPPESPTLQETRTAVQVSFTSPGSPSRSKVEGGEAFNQVYDELNNKMDEFESQVSTGGQLQEAEYSRGLEEVVKTVDEEKQKLLREIERVTEQGEQLLHAAETSRDPVTHARVSNKLQELKIRWLSIQRDVESKRHEVATVLPGLRAGGEDREEFIHWLEEVEGRVVKPRTHEDTQVLEQEVRERGKDLLALQARTQELGERHGARQLVAAGLDLSQLDQRHRALVAQLSLPATPSPVLEEKVEAVMVAASATAPLAATPATVVATSASSPVVATSATVVATSPAVSTSPSGVEQTVTKTTQVKAYAVSESVVNMTRTPDPVDPSIVDRTTALAHNPEQYLAELGRLRAQIARLRGLIEREEQVPSDEKSTREMDTRIKALDQNVWEVQEHLAELESQKDDVILQASQEHAGNILSQMEQMLQEWSKLSDAHANRMKKWHTTVEQWRIVDSGTKEMTAWLDSAENKLTTARNTLGPEEADQMYKELEVSLRQHQGHVKKINSASEEILRESIGVPSNPLSDRLELINHRWEVLCSEVFARQKRSKESSVEPQDFTNDMDELFSWIDETENMIGSSLRPDVHYLEALLEKLKDREDEVATRQASLSSINTRGAKLLQSPTLTEEDRANVRRDMDSLNEGWTKVTLTVPQKVVQVEEELRKVKTLNEGLDDLQNWVDSTKVVLATQASPVKSLTEVDGNDSVIIDRQTTADAIESQEVKLNQLSQVCGQYSRSLQAQGLTMPEVTERKLKSVTSGLEEVKEMSKNISERTEPHIAEVMVQVKNVQQVESCPTQEVAPPTPSSWLDFDKSISELRDWLTLSEHMLKSQKVTVADLKDIEQMRLKLVNQLHEMQVRQKQLDQVSGLSSQLQSSIDSPSDRQALKDRTEKLQSDWMVTGEHLTQRKSVLEGMLESSRTFVQSYAGLEQWLSTSEGELDQVQTQQDKDMLAASHVKLQKELSEHQAVVDSLKTQGTQLLDNYSEEDTWQLRRQLERLTNRWSTLSNRLANEGKAIQSGKESVEEFEASFQKFNDWLVTTEQSFDALSRQTAPQELGDNQELAQEYLEQFKDLQADVDCHQPGIESLHQSGNQVVRSMGARESHKLQARLEEMNKRWLHLMEKSMEIRGRLESNVEQWSRLVKTLQSLVSWVSARQVDLQQQQPVGGDLASVQRQLVENQRLRQVLELKRPLVEQSLDAGKFYLKEEGEEISRYDSGGESADDSGSEPVLENDAPNLMRNIKRQVHVLNKKWTELNQSCLNWQIKLDEVAERMSIFHESMDNLHDRLVAAERETRDWPNVGDIIIGELQTEIDRTKSFQLKFPLQGEVDDVTDQANRLQENHVILSHHNVHRLEDFSQRWASLNQMLQDRLQHLQDALNAYGPNSQHFLTASVDSPWERAVAGNKVPYYINHATETTQWDHPHLTVLMDALIELNKIRFAAYRTGMKLRMLQKKLCLDMVPLQSAVDAFDSHGLRGRNDKLIDVGEIIECLSTVFEAAAKEHPDIVNVPLSVDLTLNWILDVYDSVRSGKLRVLSFKVGLICLSQAQLEDKYRYLFRLIADTNAFSDQRKLGLLLHDCMQIPRQLGEIASFGGSNIEPSVRSCFEKANGRPEIEASHFLEWLRLEPQSLVWLPVLHRLAAAETAKHQAKCNVCKEFPIVGFRYRCLKCFNFDVCQNCFFSGRIAKSHKLTHPMQEYCTTTTSGEDVRDFSKVFKNKFKSKRHFKKHPRRGYLPVESHLEGDSLESPNPSPQHSISQDMHSRLEMLTSRIAEVEQRQGAPSDVDDDEEHKLIAQASNTLSTSRPEEEHRLISEKTKALSNQSKEGHKANCENSKVLSDQRKDEHKVIADDPRVLDLSKERQEEHKRISDYSKVLSTRREDEHHLIAQYCSSLKGDPSSHALKSPMQIMMAVDADQRQQLENMIRDLEDENKTLQVEYDRLQQAAQQRSDTSFLLLSSEENNGGEASGDHNEEMMAEAKLLRQHKGRLEARMRVLEDHNQQLESQLGRLRQLLVQPQADKSYLSIDSSLRTSPMTTPSSSQSSLPAGSGRYRFAPTFESTPHTNGNTNANDSLDESGVSLGAHAPPTYSAAKMRGSNNVGDLFHMAGEVGQAVGSLVTVMTDEEAAALNGSDNTNAIKHTEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AED0</accession>
    <name>A0ABM1AED0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101862768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946069.1">
        <property type="nucleotide sequence ID" value="XM_013090615.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862768"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="52"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012946069.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19970" checksum="F4AC872B2261B179" modified="2025-10-08" version="1">MFNNRHMENQRRKTLVVPAVDPRTHEGTYTCTAQDSFTQTSSSFFLPIKYAPVIDRLPVQTAAVGGDAKVACWFNGYPDSPAERWMKDGQSIPVDRTRFNPARDARYHTGITSYRLKIYNVQQTDYGHYSLNVSNSYGSTTCHAMLKDPAEIIDLKPAPKQADPEKCCAESGVSQLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AED9</accession>
    <name>A0ABM1AED9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent RNA helicase dhx29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946084.1">
        <property type="nucleotide sequence ID" value="XM_013090630.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847629"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056890">
        <property type="entry name" value="UBA_DHX29-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24899">
        <property type="entry name" value="UBA_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase DHX29-like UBA" evidence="2">
        <location>
            <begin position="93"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946084.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32111" checksum="1704257C4C72281C" modified="2025-10-08" version="1">MGKRKVQNKPSQTAPSAEGGEDKKEESKTKGKKTYSLQQQKGAAAQSGDAETSELPKVRLPDKLESALIEQIGEEQRSRQGQRDVSKRLTSKKLTDVYDSLLGTGFSRTQVEAAMSNCIMGGGDLIDALDWLCLNTQNDQLPAGFSETLQKEEEKRRPKFDLSLHEEKDLRLVASQDSGGEKGETSSGGKSTRSETPSAKTDKGGGGGGMKNWILQYAEQSSEEEEEEEDEGGDASSFNPTKRYADLHRQLQEVKSQAAIAKSSGATEKHKTLSKQLKEMHIGTTRMMIFSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEU1</accession>
    <name>A0ABM1AEU1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Somatostatin receptor type 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106013948</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012946326.1">
        <property type="nucleotide sequence ID" value="XM_013090872.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013948"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF67">
        <property type="entry name" value="FREE FATTY ACID RECEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046057361" evidence="9">
        <location>
            <begin position="22"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="14"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012946326.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="46842" checksum="CC7A0F992BC885BE" modified="2025-10-08" version="1">MSVCCKHFAIVFYLIFQMISALSRDRCAHTGTHSLLINLACSELLFSLGIPIVVTTRLTIDWTLGDPLCKLVNYTEFVCGMSSLLSLATISVDRLLCVRQGGQLRLSTTVTKLIIVIIWIISLVFSAPVAVAETTLTASIGGSDFQICTSNQTSNGRSSSVASNDGLLQNCTQFCQQRVFCGVSWPHGFDAASYLISIAILCFFVPTVITCACYAYIYVIVMNSSRNITRQSQASLDMATCGPSMTQSSQYCDRSQPPPHPHRRPTTTASSCHVIEQPRPSCDVRRRQDRLVRLTSAIVLTFFLMWLPFFVISNLASSQTRVSSTALTLTLILAHSNACVNPLLYGYFHPACRRQREQRRCLKGFPLECFRCCCCCYSWCFSEGSVGPAMNEEGGNSCGTEEAHRCSMGRYTHTSPLATPTMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEW5</accession>
    <name>A0ABM1AEW5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SPRY domain-containing SOCS box protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101860788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012946356.1">
        <property type="nucleotide sequence ID" value="XM_013090902.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860788"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12876">
        <property type="entry name" value="SPRY_SOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035754">
        <property type="entry name" value="SPRY_SPSB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF12">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="217"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012946356.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30325" checksum="4D1C7469E2B11CBE" modified="2025-10-08" version="1">MAPNPSDIDNEAYNLSNRFEEVKDPLLYLQKHDALCKEAWEWSETDKSYDASLHGDDNKAAVTFHPFWSNGTAGIRANRPLVGDINYWEIHIGDRIFGTSLMFGVTTQKARLQANDFKNMIGEDIHGWGLSHRGRTHHNGMSSFFCRSFPEHTPTIVGILLDRRRGDMSFYKDGVCLGQEKERERASPFQGLDRVESDLYPTICSTAAKSAMMVGTRYRSFLNLQDRCRHVVAGSVLAGCEFKGDRVVRAQELPVPRKMKDYITMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AF49</accession>
    <name>A0ABM1AF49_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106014026</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106014026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946481.1">
        <property type="nucleotide sequence ID" value="XM_013091027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014026"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946481.1"/>
        </source>
    </evidence>
    <sequence length="729" mass="78972" checksum="41B40E315273742D" modified="2025-10-08" version="1">VSSHRPMWKPELSEPWRYPAVCVITEVLLTPDRVEARDSNNSRVFSPPTSLSVSREPTALPLPISSTSHDNLTGAANTELQTPQTSQIFSVSPSASPGLRAIASRTSSLHSGERRTNTEDQERCLVFSETVAKKISSTDDKSEGDYESDDNRRSSSNNNNGNNNEKEEGNNKEGEGEEEGDDDRDKEGNNNRNNEDNSVIGFGESTGEICAGGLTTRDRVYLLWPAAQTQSDTRQQREEAGTAEGKEKEEEEREEEEGEDGGAAARERSIEERAIEGWRSGERKPSGCGVVAEVAAERSYLHDYDYDHDSAFSAISSVREARSSNLASPVDTGGAECVCADTDPSTSDSFTERGQGAGKSLPFSESDSGGKDRSLQPHTDRRSARVSGQGSLGEGELLSSNNSTNFYTCVGFNSDQENSPKGVRSDDVSAGEIIREDTTLRNPRHSHNDCLTHEEFVFESHPPGRASDSERFQEGINRDPWCFDSLSDSGVSFVSERDVVFQDAPTSDECASLPLPHSASVSAGSESNTHATHYPSTHTEFSEKLDSACAIYNADVIGNVKYCQCEILCDCFARNLHSETVRYPPSQTNPLIPSVSDKGLSYLDSGESSNWCHCSVTANEARPLVISTHADRCLASRDPGGHYLRTDQRSHDGCSKGQSGVGAGVGYELTVQCPVDNFSVKDSNRSHPPVPPHTLVSGPVTTLNDRAASKTVGAEGNCHIFVDNTTNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFJ1</accession>
    <name>A0ABM1AFJ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhodopsin kinase GRK1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106014139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946663.1">
        <property type="nucleotide sequence ID" value="XM_013091209.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014139"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012946663.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16448" checksum="4A8852D5D17BBA82" modified="2025-10-08" version="1">AAVSLRSLHKKQIYHQDLRPENILLNTRHVAFISDFGAACLLLEGCDKVDTWTAALGFRGPEADQEDGQFCPFQLDIYSLAVSMWQVLSGLCPVKNKPFDHLDNIPPQYAALLRNLLLPDPDRRWTLDKFLTEALELHPDLSCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFK4</accession>
    <name>A0ABM1AFK4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-gated cation channel beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106014152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946680.1">
        <property type="nucleotide sequence ID" value="XM_013091226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014152"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946680.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19001" checksum="D49A9FEE5C5805E7" modified="2025-10-08" version="1">MNHGEPGLEATECGAVSGDITERGKRDGDKRDKEKTERKEGEGEEEGSAVDDTTSLEQETHDCSKGGQEEEEERAMASGGEDGRGLEESAAEREERQARDRRGSDHRGQGLVSPPDGRGSEESPATEPVSVEKQDTEKKEKTILPGDSGADKAASQARVVSPVELELGGLIYAPPPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VNU0</accession>
    <name>A0ABM1VNU0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">BTB/POZ domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10 11 12" type="primary">LOC101860388</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005092377.1">
        <property type="nucleotide sequence ID" value="XM_005092320.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005092379.1">
        <property type="nucleotide sequence ID" value="XM_005092322.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824081.1">
        <property type="nucleotide sequence ID" value="XM_035968188.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824082.1">
        <property type="nucleotide sequence ID" value="XM_035968189.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824083.1">
        <property type="nucleotide sequence ID" value="XM_035968190.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824084.1">
        <property type="nucleotide sequence ID" value="XM_035968191.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824085.1">
        <property type="nucleotide sequence ID" value="XM_035968192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860388"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005092377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005092379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035824081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035824082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035824084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035824085.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="54543" checksum="6631B3E220A9A083" modified="2025-10-08" version="1">MAERAAPPVYPGLEEATLADKASNNSDNSDDSGVVDWKDPKSVLERNRHMLVSQMSCDVMFVVGEKKERQGAHKYVLSSRSDVFRHMFAGPEGIKTEFEVPDISGDHFWEMLRHIYCEEQKLQVMNVVGIMYAADHYDLIDLKRACKKFLQANLEIENACYLLMEVRNYGYPEEEKEIIAYIRKNAEDVFKTVGMGQLSRELLNELLTLPGLDVDEKTKKEVTDSWAKNHCEELKREVSIENVMDSLQDCLYVYRDDSASHRYVMDSVTTRSIFEEPEEPVTPPTPEPVSNGVDETDGMSTVSSTSSMRSRSSVHTYSRLPSCNMWPDLEQVTRLQEVHGSDQNDAMMADAFSFTVDQNIYLFGFSIYGPKKEAEGKYQIDTILSRKKKDVVMETINIKGAGIILPVMFERPVKVDKGLPYTLEIYIKGPSSHMGSSGQSKIQHGPILFTFSDAAKVKRNRSNVSKGQIPRLYFMPRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VPM8</accession>
    <name>A0ABM1VPM8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DBH-like monooxygenase protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824370.1">
        <property type="nucleotide sequence ID" value="XM_035968477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011129"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="85"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824370.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40739" checksum="354D0D4EFC08E099" modified="2025-10-08" version="1">MKYDGGFIFSFNRLRSSVIFIGKMRWTQSLLTSYCLLVTSWVSGERLGTPIKNNPAASVTSAPPVIDPNKPASSRKFLFHSQLDENYDLFWDFNDTHITFETLVKTNGYIGFGISDSGSMFPSDVIIGWVKDGHNHFSDRHANGHFMPAKDTVQHWLLLGGMEQGQYTRLTFVRPLDSCDSQDKPIKAFDYPLIAGQSMGTAGDPGYFKMETHYDNPDMRADFVDNSGIRIFLTQQLRTHDAGVLEVGVNVDPYQIVPPNNPSFLSTGHCHPNCLSEGLGGQEIRVFSNLLHAHLIGVKLRTRHFRNGVELQPIGEDNNYDFNFQEQRYLPQERVVKAGDYLVTECVYDSRGRAGLTLCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQB1</accession>
    <name>A0ABM1VQB1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">5-hydroxytryptamine receptor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC118477384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035824603.1">
        <property type="nucleotide sequence ID" value="XM_035968710.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477384"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035824603.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34008" checksum="01F2703E27A79B70" modified="2025-10-08" version="1">MTGIFLFYNTTYNMSNFQIYKECLARYGLLVFLIVSSVLHLVFLSLDRYFKIVLPYRYGEWFTVKSMALVSAFIWFLSLVFAILPLTGWNTTPWEVPPDLSKPDEEDDVLLCSFFGVLHQDYLKFLVIIFWIPFFFMGIFYAHIFKIAHRHARLIAAQEGGGPGASSKDRHSWKYTKTVVIIMGVYFLCWVPCGIVIIMFLRGHLNEWTLIEQGTLLLYTSSTAYVNSLVNPIIYAFKISSVRRRFLQVFCCKSGSSAGLEPSFYTASQKRKPSGHAAHVRHVPNKSTNVLPEISSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQL3</accession>
    <name>A0ABM1VQL3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Echinoderm microtubule-associated protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC101855006</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035824705.1">
        <property type="nucleotide sequence ID" value="XM_035968812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855006"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21931">
        <property type="entry name" value="TD_EMAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049813">
        <property type="entry name" value="Elp-1-like_TD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF50">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="10">
        <location>
            <begin position="319"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="612"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="11">
        <location>
            <begin position="619"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="695"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="741"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="853"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035824705.1"/>
        </source>
    </evidence>
    <sequence length="888" mass="97920" checksum="DD7B842D8BEDE089" modified="2025-10-08" version="1">MAVSTVQALFNCLKLCFLCAFILVVVTVKFLRRHERPQSLRLLISEGKILFWNTGAKLRAQFNGTSDALALTPDGLLSHDKEDVVERVAYLEKKVQQQEDEIVCLKSAMADVIRRLGSVEISSQNHALPSSSSTSRGYRALPSRPRSMVGGSSSSKSHLNALDNVNVMSQRNAPNSSRSSSGRSSRMSSAHTLSKWSSLSTSAEMSNSMLTPTSSRGKPRDVQTVNVRRKKSKEPFWNQEDGFLKIYIRGRGVSLYASSNLSEYNINKTSEVPPEKLQLEWVYGYRGRDCRSNLYYLPTGEVVYFTAAVVVLHNPEEQTQRHYLGHTDDIKCIAIHPDKIKIATGQVAGHDAKEGKVDPKRRPGWKPQTDQEPHVRVWDSVSLNTLHVIGIGCFSRAVCCLSFSKLDGGQQLVVVDEANEHIISVWDLGRDKPHKLTETKSSTEPVLAVEFHPSEKGSIVSCGKGQITFWTLEGGALVKKHGIFDKYDKPKYVLSLAFSDSGDVLSGDSNGSIFVWGKGSNRITQAMLNAHDGGVFSLCVTKDGTLLSGGGKDRKIIQWDNTFAKTGSETEVPESYGPVRTLSQGKGGLVLVGTTRNCILSGSLDLELSVIVQSHTDEMWGLASHPTQHQFLTCGSDKQLYLWDSQSRTVVWNKEMNDAVHSCCFHPRGGIVAVGTSVARWLVLDLSTHEIVSVHTDGNEQIECIQYSPDGSMLAVGSRDNYIYIYQVSDDAKKYTKVGRCSGHSSFITHVDWSEDSQYLASNSGDYELLYWTASSCKQLTNPAVIRELKWATQSCVLGFNTAGIWPDGADGTDVNGCCKSHNERLVASCDDFGKVNLYSYPCCQPKSNCHSYKGHSSHVTSVTFLFDDSRLISTGGKDTAVMQWQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VTT1</accession>
    <name>A0ABM1VTT1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RAB11-binding protein RELCH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101857949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035825823.1">
        <property type="nucleotide sequence ID" value="XM_035969930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857949"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040362">
        <property type="entry name" value="RELCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059:SF0">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035825823.1"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118872" checksum="486783BF15AD700A" modified="2025-10-08" version="1">MASLLPKSDSMDITWDSIAAKLLRDNYILTALELYTEFIESGRELPRLRDYFSNPGNFERTKEDTPSPTLPRTSSVQTFDSLDFARYSDDGERQVDERVAVLEFELRKAQEMIKSLRATLTQQAETELSTPESQKKAGLGDDDGELITPVEKKALNFLVNEYLLQADYKVTSVTFAEENDDQDFEDWDDVGLNISRPPGLAHLLKDYSSHVSPSKDTADVGVGVDMEAEQLGQMEMEWTGRTRELESQISSQEEQIRLLTQENEILAQQVDILKIGSPRGSMLQAKANIPHRDRSDSDASSTTRDETLKEDNLPAQPSLANLAHSRPMGSSHDDLRSDEANSRPPGHKEGSPQIVVDFVDAVDPTVVIGERGEGEGQEEIEAGHAGGGVGHAGGGAGPVISQTVETEAPLSGGAGGGNSAAPDRPRKKEVTVRPSDNRKMTESFRKALLEVAFHVSQDNHIVSEMSQLSECDQHGVVRMLSRSLPHIVPNVLLAKREELIPVILCAAMLHPEPKQRDQLLNILFNLIKKPDDEQRQVILTGCVVFAEHAGADRLVEELLPQCWEQIGHKYVERRLLVAEACGALASYLPAEIRSSLVLSMLQQMLSEDRDEEVREAVVRSLGLLMGFICDEDKYAQGYELLMSALKDSKERVQRAALHVFLPALGMWARELGRLEHQLMHSLLRQLEDTGAAAAQKANSSTTLPLNESRFLLLLMTLEELVPLLFLTVVETCPQEHVFSEEEVYVDTSRFPGASSALSDLAVMAGSDASLVTLVRQFEGHLDQEWFEPWEEMNWIVNNLLPRMLEVTMSVGLSMQKVVHALCHFTFRLCRTFGRTFTEKKVKPKFEELIEIPDEDFDAQLNQGHLAISTCIVPVYASGVLMSFVTDEDKSRLSQFLKRVLCTLAFCQAPLDSLKATLIELSDNPSNHELLLSVLWDGVVHSSAQVRAAAAAVFELMIKGVNETLVSSRVVPALVTLSNDQEMSVRIATIPALGAIIENISIREVLDRVYMQLQMFFDEPSYRDQHAVHVELISTLARCGPSAEPKFRDEFILPRLAAMASANNNMGNETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUK2</accession>
    <name>A0ABM1VUK2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium/calcium exchanger 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC118477820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826094.1">
        <property type="nucleotide sequence ID" value="XM_035970201.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118477820"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF70">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calx-beta" evidence="5">
        <location>
            <begin position="64"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826094.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17713" checksum="46EE1C3CE61530D1" modified="2025-10-08" version="1">MRRAAAASHFTHLSTYHQVFQENEYKKTVTVPIINDNQYEADVDFYVILKNPHGGTGIGDPSVTRVTIVDDDEPGEFEFEDTHYHLDCKTGKVTLRVMREHGFDGKVSMDYSTVDATAVGGKTLGANVDYVTANGTLHFEHGETSKSITVDVSKTVKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXL9</accession>
    <name>A0ABM1VXL9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen alpha-3(VI) chain isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101863042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827162.1">
        <property type="nucleotide sequence ID" value="XM_035971269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101863042"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.20.10">
        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046136122" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="31"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="292"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="488"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827162.1"/>
        </source>
    </evidence>
    <sequence length="1110" mass="122330" checksum="96E3C1A1E724B8E8" modified="2025-10-08" version="1">MGYYPLLFGALVSMVLCTTVAEEKKCSAPVDLLFLVDKSASIKPHQFKVEKEFVAKMIEKFDIGPDKVRVGLVLFAIKAHNKFCFNKYSTQEEVTKAVAGLDCPKCERGKTGTGAALQMGREVSLTKECGAREGVKKIVVVLTDGRSTESPKYLKQQAALMKERAQVISIGVGKVKKSELELLASDKSLVFMTSDFSKLLPMLENVATKACEVAEKEPTPAPTLAPTIAPTIAPTIAPTKAPTLAPTLPLTEPPTEPPTEPPTEPPTEPPTEPPTEPPTESQTPAPCTARLDLLFLVDKSASIKPNQFLKERDFVREVISNFKVSPTDVKVGLVLFANGVHDVFNFNNFSTTADVLKAVEELSCPTCKRGKTATGAALEFGRKFSLTEAWGARPDTPKVVVVLTDGKSTEPPTYLREQAIQMKRTGALVISIGVGHNIQKSELRVLASDRSLVFTAQDFDKLDHILNEVSTKTCDVAVKDRVFNAKLDVLFLVDESSSVGVDNFKLELSFVRNVTRKFSLGVKGSLFSVAKFSTDVSDVFCFNDVQNIDDIYRKLDKAEFQGGKERNIGKAFKHALSKSFTARCGARQGVPKLVILLTNGPSANTKLAIREAKQLVHFGVSTISLGIGSGLDLQALQSLCSSDDMAFHRDVFSQISGLVTTVSLVIEEVALRPGLDVPCWKKELCAFNLVCRKVKGSRRCSCKGKQFFDTQESRCRKRVSNKIPVPGYQERCSRKCQSNLECLEQGSQKQCLCADGFYWDEDAELCKQNALPGYNEQCDMSCKSNLQCLQHGSKKLCLCADGFSWDADEEQCKQENSLPGYNEECDKSCESNLECLQHGSQKLCLCADGFSWDADEEQCEQNSLPGYNEECDKSCESNLECLQHGSQKLCLCADGFSWDADEEQCEQNSLPGYNEPCDKSCESNLQCLQHGSQKLCLCADGFSWDADEEQCEQEISLPGYNEQCDRSCVSNLECVQHGCQKLCLCAKGFFWDADADQCQKENALSGYKELCDKSCVSNLECVQHGSQKLCLCTDGFSWDAAADQCQKENALPGYNEQCVKSCGSNMECVQHGCLKLCLCAKGFFWDADADKCSKESMMNEMLVKYRHFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXV1</accession>
    <name>A0ABM1VXV1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protocadherin gamma-A5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101856831</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035827244.1">
        <property type="nucleotide sequence ID" value="XM_035971351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856831"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047277507" evidence="12">
        <location>
            <begin position="25"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="793"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="55"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="127"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="244"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="368"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="466"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="570"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="680"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="827"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="866"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="895"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035827244.1"/>
        </source>
    </evidence>
    <sequence length="1068" mass="115909" checksum="CD5B9EAE0505620A" modified="2025-10-08" version="1">MAPKAASVCLFFSLLAILVLSGESQIILEVQEEQGHRLLLGNIGSRANISNIPGLRYSLVSERDRFEVDETSGDFYTRSVLDREQLCGSVPRCVVSTSVAASSDNFFQRYNVEVVVMDANDQRPRFSQRMFSKPLSESAAPNSTMIRLPVAEDADYEPLFRVQGYHLEPRTQRTFDLVVQKTDRPDGSSDFDVSLRLLRGLNREVTSSFSLVLVAKDGDGPDQRGTLPIEIVVADENDNEPEFTEDHYTKKVKESTAVNSTVLTVSATDADKGENARVSFEFPNDIDRTVRSYFAIDQSSGALKLLKSLVKEGGSVFSFRVKAYDHGLPSLSSEVEVRIDVEDTVNDPPSISVIPLRPAGGAEGGALVAEDASLDTRVALVDVTDSDSGENGRTSCSATSEYFSLQADPNTPGAYTVSVSRPLNRESDASLKVEVSCTDYGTPPLFSRAELSVIVEDVNDHEPEFSRTIYEMEVKENQEIGELVGSVLATDLDEGVNGELRYSLEPGIAEFDVNELNGFIYTRVKNLDRETTDTYRFEIYAFDVSPQPLTATATVVVRVQDLNDVWPRFDNSSYKFSVSESLDPGVQIGRVLATDKDLNQGGVVQYLLVHSVRHPDPPFAVSVSDGSITLTKPLDREMESQYNFVVTAFDLGIPPRNSSVDVQITILDENDNAPVIAFPTADNLSVTLNLDVTPGHEIIKVIATDQDAGENGRLTFSLNSHGNASAASRLFWINEDTGLMTLAVPLTPEDVRVYNVVISVHDHGAHQQRATRALLQVEVVQALEHSRDSDSNITIVIIMVCFTLVVAVVVLVTLCFIKYIDKKKFDADRKNDPGKQKLHQTSVASPDSYERAGSGDDVMENGLIVSPSLQKQPPSFSSQQQSSAHYQHPQSPMGNGNGGAGGGGGGGFTGGVVRNGGKKSVTFDSEVRTSDSSVPSECLGDDHVDMAFSTFGHTPETYQHSPVPVSLDSSSAMLLPNPAPFRTAGVLPVLTTPTTGFANVTNPAHSRAGSSLSQQHGLTSSGMRAMEEVGGPDEVIDVALQKHNALVRSMRGNGRRPQHSSRQVGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXV4</accession>
    <name>A0ABM1VXV4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitin deacetylase 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118478213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827247.1">
        <property type="nucleotide sequence ID" value="XM_035971354.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478213"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF3">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035827247.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23570" checksum="2BBE9532E2D83C06" modified="2025-10-08" version="1">MCELIKRGQVETTWYCNFVCSNQERKKEKNLWVGLMLYTQNTHRLLVVSTECSPSNCQLPSCYCPGTAIPNNMPVSSVPQMVMLTFDDEVSAAFYGYYQRLFRPGRYNPNGCPVRGCLFVSGSGTTYDLVYPLYALGVEIASHSVSHRFPHTWWSGASYKDFVDEAKGMRDNLINQAGVPRSAIKGFRVPFLQLGSDNMYSALYDSGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VY19</accession>
    <name>A0ABM1VY19_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">MFS-type transporter SLC18B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC101851287</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104784.1">
        <property type="nucleotide sequence ID" value="XM_005104727.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005104785.1">
        <property type="nucleotide sequence ID" value="XM_005104728.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827312.1">
        <property type="nucleotide sequence ID" value="XM_035971419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851287"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="78"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005104784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005104785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035827312.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="57994" checksum="D380DA0A79DC07EF" modified="2025-10-08" version="1">MSATAHQREKSPLLGSDHQSGSYSRDDKEVNSVQGVEAGSSKASTGAAAEKDGAEGTNGTEPEEPFSIRALSNRKKYTMVMMALANLFTGCGFSLIAPFFPQEASKKGVSTTVTGIIFSVFEFVIFITSPVYGNFLTRIGPKFMFLSGTMVGGTCAILFGLLDKCPPGTPFIVMCFLCRCIEALGLSAYVTASFAIISNEFPKHIATVFGILETANGIGLMLGPAVGGGLYELGGYGVPFFVIGTLIILNGLFLSKFLPPPQNFFQKRKGSVFGLLRSPMVLIAIVTILAGACGIAFLDPTLAKHLDKFKLSTGLVGLVFVVVPGLYGITAPLWGYISDSKNIQAPLLILGNLVCGVGYLFVGPAPFLPFIPFELWSVILGLVFVGFCIGCAVVPTMKCLVIGAQEIGFEDNLDTYGIVSGLFNSLFCLGAFVGPTLGSTAVEQLGFDWAAVIVSCIHFAAMICVVIYFTLRRIRRKADNGPEAVSHYTSLPIDENDRQALLDPEVVLSHGSLSSVSSRSHNENVDRRRSNPTFMRSVSHPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZV3</accession>
    <name>A0ABM1VZV3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger BED domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035827946.1">
        <property type="nucleotide sequence ID" value="XM_035972053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859433"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035827946.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="46878" checksum="D981451549B9A7B3" modified="2025-10-08" version="1">MQPFSIVEDRGFRRFIQALDPRYEIPGRKKITQVIIPRLYKKEEALKKELENTEHIALTTDEWTSRTTKGYMAVTAHFIDNNMTMQSRVLEIRSTNAALAFEAEQRKEIENGEHFSQMEKDEEHSQMEDSAEHRIVDAPKKLIQEVKTRWNSTYYMLERFSNLYKSANRVLADHMRHDLPLNRMDLDLIFTAVEALRPFEEATREMSGEKFTTIAKVIPMIRGLKEQMSIKLKKKNCPMAKELQTQLQQRFSCPEESFIWAASTFLDPRFKKLPFKDQNQKEMLETVKRRLSQQFQPPDPEEVQPEEAVRPQVPVYKRKDSIWASHDEAVESQQQIVEQPTVRPVMEMDKYEKETSAQSKKPLVLVENERLHDARNGKARQNVSIMPCYKYTERAPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1M6</accession>
    <name>A0ABM1W1M6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein turtle homolog B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101862613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828569.1">
        <property type="nucleotide sequence ID" value="XM_035972676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862613"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF32">
        <property type="entry name" value="PROTEIN TURTLE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="73"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="197"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828569.1"/>
        </source>
    </evidence>
    <sequence length="658" mass="72147" checksum="2C675E607F798E84" modified="2025-10-08" version="1">MPCHGVGTPAVTTAWSKVWGRFDPSTDDRITLTDTHLEIRALTKDDHGKYECKATNTIATVVTVTELRIENTTPHAPYNVTVLPGHFNVTIRWEPAYDGGTPQHYLLWFRESSPIPMSWVTMSIPSSATRSFKLFSLQPATEYEFKILSRNQLGNGSFSDVVIQSTLGYDRAVVTALPVNRQGQPYYPDVTINHGPQPSAPLNLSARVKDGDILLAWIVPLSSPVPIFSYRIEYSLNGGTVIEHAPLIQGGDTRETSMTGMPSGTYDIRLRSYGVMAYSRVSNIVRVVIAEDGGGSSPSGKAGASSSSSDGPILPEALVGGIVGGVLFLLVSVLLALVAIFHSRRKGRCTKDKKYNDVNYGKPDEVNGRQHEPAAKRDRWQQNGGGGDLVTSLNNTDSIFFLPQTRTLDQSSDMRASLLSSQAWDQGRGGGRRVDGGGGGYFFDDDDRDLGGRQVPLTNNETTTTTADFVTLTDGSSRPGSSGVVRLRAPGHGRRHGNSDSNDDGEDDYVDDNNARNLTWPERYYGPHGQPAAAAATMLSRSLPLDRMYYDPHGRFLDHDPRRSLYGEQPPAFYSPTSPPHPGPRGGHHQLPHHQHPQHHHPPLLKSRSFPSHPSTDNDDEDDDRNPHDFPRLADQYPSRSAHPLLPPSHHHPFSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W2Z2</accession>
    <name>A0ABM1W2Z2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of G-protein signaling 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118478828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829035.1">
        <property type="nucleotide sequence ID" value="XM_035973142.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478828"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046995">
        <property type="entry name" value="RGS10/12/14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945:SF3">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="15"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="118"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829035.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33670" checksum="E80F84C8E35AAF7A" modified="2025-10-08" version="1">MTMRIKFESAACCGGRNNQACVIYGRFLSPTADDPVNVDDVARSHTRMFLDNPTVDMFDVAQKQIHQLMRRDSYVRFVKSDLYKNKLMEEMEDKPGQTGDQGDGLKEPVGRVASWAVHVDKLLQDPVGVEVFSEFLKKEFSEENILFWKACEQYRQLTDDSERNAQAGVIYGRFLSPTSDDPVNVDGAARSHTRTFLDNPTVDMFDVAQKQIYQLMRRDSYVRFVKSDLYKNKLMEEMEGKPLQGQMQDKLPEGKREEKRGRKYGASSGILTLLKRFGLKDARKRSKKKGGVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4L5</accession>
    <name>A0ABM1W4L5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-sulphoglucosamine sulphohydrolase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106014023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035829608.1">
        <property type="nucleotide sequence ID" value="XM_035973715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106014023"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829608.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20986" checksum="EF6618706416ED96" modified="2025-10-08" version="1">MGLIPDWTPQIYNPDDVIVPYFLPDTDVTRQDLAAMYTSFGRMDQGVGLFLQELEKAGHLDDTLILFTADNGIPFPNAKTNLYEPGMGEPMMMSVPQSRETWGKTTEALASTMDFTPTILQWFDVPYPDYTLNGLKVSLTGRSLLPLTSSHQGAAQNFTWTYSSHDLHEVSFVLPSWCHFTRTINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W5A6</accession>
    <name>A0ABM1W5A6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">HEAT repeat-containing protein 4 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101845888</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089098.1">
        <property type="nucleotide sequence ID" value="XM_005089041.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829849.1">
        <property type="nucleotide sequence ID" value="XM_035973956.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101845888"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF20">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005089098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035829849.1"/>
        </source>
    </evidence>
    <sequence length="1445" mass="160100" checksum="7DB11D4D570F08D0" modified="2025-10-08" version="1">MASKLNSTLSERTMLFPCAAGVQVPQIGAEDSKVKVMLNQRSTPSILPMTIVSQDVNPASERYVQMVSSGLSFSQDVVEDRCLHMMPYDTKYFSGVFEPGELLPPPRRSSSVMGRHNKRGVDARHMPCYLKKIAKPAPLTPLRKQVKEKALQLHKEALSSKQKDISRDSFDGSTSPSSFFMTEVSSQEQAAQRPKLKPIPESRESKLSKVTLGSKQGETVKADKTIKQDDTVSRLGTAVSFRVTDEIKSRASGASIGTRDTSELSQIPKNDWDDHLMSRLSKLTANWIVHEKLPADGQKEKLAHVLESWYGPPTHTDLVREQASDGEEDEKAKEQKPKSKWKKKEASVLERVYNVRPSLAEAIDPYSDDNKAPFYRQPAGIRKKKRSEEKEEAASPRMTTETGEESRAINATAHNISVRGYTETPPMTLKDVLSPRVGNKIYNTGNAFEQEWLTGSKQVYKAGGDPNEITMDTDNKYKKQVQRELPQRPETWYTLENEKKSAEKAASSQHIPEKGQKRWVALPELIDETEGTVNANSDGFDTGMMKAVDPKQRRRVKQNHALVTIVHDWRSKWFLSGQFADSTPDDLIRDMADIQPHVRLKAIGTVAKASEYKPPPDMTVMLESSEYDPVKELPEKIFVALECLLDDSHDQVKKAAAITLYSLDRPSEKAKEQLRHMLMGSSSVDRWAAAQCLAQFGESDSDVVAEIIKQILSTEVAVKLEQGIHLLAKISNSSTLVHCMVAEQLNSSSWRHRVIACKILPTLFGSINRDITQKLSELMWHDWHVEVRRAAGQCLGKTSHGRDVHDDIRERILHGGERTKMDAINKLGQLGIMTAKLLPAFLECFADSYVSIRSEVCITCGNLGIKEEQVIDRLVHLATFDPIWKVKALAIQALGKIGVENSEIKECLLWAMRYEERPGVRAEACHSLVALDIQDDDVIEALQDRLLVESSPVVREEMVEALSLFGLSTSEDMDMVAQIKSEVRKLCTRNIIASQIIVNENDETKRAQLERMVCQTEKDIEALNEKKAVILQRIRSQARSTDSLGSTPQPRTSTPLPKTKRESESTTPEPVSREGTVFTPTADRELEAILNQEEIASASGSVSVKSRPTTGASEEMETEEYTAGAGGQDEVKVPSRITITKAADDEDAAVAQSGDDAAAETADVVDIGVIPGSAEGVEGESSKQTSGKHRLSLPLNSQKGSRLGFLSPTGSFVDMKGSRLSVAQFSDRRSVISRDSLREREKVNAEVNAIYTDLNARYADMVDDLIKIDRGLNTKGSSTDSSISATPKVMPGLVTSIDYSEVEKLLRRSINEESEESPRVEEGSGEENKGAEAQIEEEGTTNGEEQGEAGDEGEPKSQEDKEHEQQGFAESEWKSYADTLSHDGYTTDATSYPSYDENDDVDIAPSHISTAGVTAQASEYDNYSERGIDSEDETAQPINQPEGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A1X2J7</accession>
    <name>A1X2J7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative toxin II</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Toxin II precursor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100533389</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2006" name="Cell" volume="127" first="1453" last="1467">
            <title>Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Edwards J.R."/>
                <person name="Puthanveettil S.V."/>
                <person name="Kohn A.B."/>
                <person name="Ha T."/>
                <person name="Heyland A."/>
                <person name="Knudsen B."/>
                <person name="Sahni A."/>
                <person name="Yu F."/>
                <person name="Liu L."/>
                <person name="Jezzini S."/>
                <person name="Lovell P."/>
                <person name="Iannucculli W."/>
                <person name="Chen M."/>
                <person name="Nguyen T."/>
                <person name="Sheng H."/>
                <person name="Shaw R."/>
                <person name="Kalachikov S."/>
                <person name="Panchin Y.V."/>
                <person name="Farmerie W."/>
                <person name="Russo J.J."/>
                <person name="Ju J."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="17190607"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.09.052"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="DQ122856">
        <property type="protein sequence ID" value="AAZ29039.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191605.1">
        <property type="nucleotide sequence ID" value="NM_001204676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1X2J7"/>
    <dbReference type="GeneID" id="100533389"/>
    <dbReference type="OrthoDB" id="6132230at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2 5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002640950" evidence="2 5">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAZ29039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="NP_001191605.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14294" checksum="92ABD5549E51B13B" modified="2007-02-06" version="1">MKVLLCVSALVLVSVNAKVGDVCQDESTCDPGECCLEPVDSLIVSKKRFDFGPILEARNATCQNYLLEGADCESQDIWDGVTCPCETGSMCISRQKQKFFSGFFASRALPPSQPGYTSQTKCERNNEPIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-29" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B1NFB1</accession>
    <name>B1NFB1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100533527</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <title>Characterization of histones in Aplysia californica.</title>
            <authorList>
                <person name="Kohn A.B."/>
                <person name="Moroz L.L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF457897">
        <property type="protein sequence ID" value="ABR22618.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191424.1">
        <property type="nucleotide sequence ID" value="NM_001204495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B1NFB1"/>
    <dbReference type="SMR" id="B1NFB1"/>
    <dbReference type="GeneID" id="100533527"/>
    <dbReference type="OMA" id="HIFAEMA"/>
    <dbReference type="OrthoDB" id="6066210at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABR22618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="NP_001191424.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15328" checksum="5158ED279E6F9E1C" modified="2008-04-29" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAI5</accession>
    <name>A0ABM0JAI5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cartilage matrix protein isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101847386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005089193.1">
        <property type="nucleotide sequence ID" value="XM_005089136.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847386"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF87">
        <property type="entry name" value="COLLAGEN ALPHA-1(VI) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047434421" evidence="2">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="35"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005089193.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45865" checksum="0675434B2B8B4C6F" modified="2025-10-08" version="1">MFQLFCAFLFFHVAITHGGVVKRETVTVCKQRPIELGIVLDSSSSISYKDFQKSIDFLQDFVSQYDIGDGHNDVRVSLITFGKGIYRQDAFDLTSYSTKEALMEAIAQVPHRVGLYTSTGEAIEYMSQTQLSVDVSRPWAKRISIVITDGNSQIWRQTRDASQAARDSGIDIYAVGVGRVRREELLRIAGDEKNVLKVDSYDQLKEIKEMLAYKTCTEVEKTTTTTTTTTTTTPPPQTQKCGEENPADIYFVFSPAELGLESTSWTTSFVSTTVKQEEMDEGFRFGVVSGSCPDDEGFDLDDYTSAEEIDNRLTSYLRPRMSGLVKRLSTSGYSQVSGGRSEARDVAVLVAKSGKRNKGLEAEVRLLQEKGVQVFIVDPTGSTISIEGATTLTGLTAKEASTNLVSHLCPVRTGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAT4</accession>
    <name>A0ABM0JAT4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">5-hydroxytryptamine receptor 1D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101857451</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089416.2">
        <property type="nucleotide sequence ID" value="XM_005089359.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857451"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="405"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005089416.2"/>
        </source>
    </evidence>
    <sequence length="540" mass="57502" checksum="A6EC7B6238AA51AC" modified="2025-10-08" version="1">MVAVVVMPLAVYMEVMSQRWLLSAPLCDAWVASDVLACTASILNLTAISVDRFIAVTQPIKYAKHKNSKRVFIMLAVTWIISVAIAAPIALGVNYSEDRRVRDCRFFNSDFIIYSSMGSFYIPSIIMIFLYWKIYRVIRQRARKAKQAKHLKDVDKRALQGVIENPTAAAAPSVAAAAAAAAGGGGGVGGGGGASMGGVYGGPSEATVTTGLAKMDNGRVTSYNTTTSTTHPAASLLSAGPHGVDECSVMTNAHSQSASDDEDDDDTGSGSANNNSGGGGSGSGGSSRGVGGGSGGGGGGGGLMTSVRDNGRLSKHAEMAELIANPVAEEIERREEEERRAWEEGGRKEEEQAMLQFGGNNGGFSAPEPAGSVGASTSGIMAHTCAAHEAETPFTSLVCKGDTSENSDQCQEGSGKKKGNNGNPKRGHKGVTKFNFHRRTSRKRKEKSSSKREKKATKTLAIVLGVFLVCWVPFFTLNIISAICIRYDLDDLPACNMNPIYFSLFVWLGYINSFLNPVIYTIFNPEFRKAFRKLLTEPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JB34</accession>
    <name>A0ABM0JB34_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC101850379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="RefSeq" id="XP_005089580.1">
        <property type="nucleotide sequence ID" value="XM_005089523.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850379"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10813">
        <property type="entry name" value="GH38N_AMII_Man2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="7">
        <location>
            <begin position="516"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_005089580.1"/>
        </source>
    </evidence>
    <sequence length="1086" mass="124539" checksum="0D47AB7FF59936F1" modified="2025-10-08" version="1">MEHVPFKHKRTTLERAEKFISEHYFTDINLRNRVYPAKAPLKELKHCAVQDRIPYRDVLNGKYSFSPCAVGDSFGPVWSTHWFALTISIPPAWKGKEVHLLWNSLSEALVFVQGEPMQGLSGDNGRTSFPLCSCATELEFTIYLEMVCNTRFGIGCGATQREEDANKLYTISQAEIGLFDRDIHELILDVEVLHDIAKELPDTNQRGFQALYTVNNMINTIDFEDRSTLEVAKGLAKKFFSQKNGDSQHTLYAMGHAHIDTAWLWPYAETIRKCARSWSCSLRLMEKYPDFKFMCSQAVQYDWVKINYPSIWKTICKFVQTRQFVPVGGTWVEMDGNIPSGESCIRQFLYGQQFFMKEFGIKCKEFWLPDTFGYSAQFPQILRHCGVDRFLTQKLSWSIVNKFPHHTFFWEGIDGSKVLAHFPPGDSYEMDGRVRELLKSVQNFQDKGRSNHSMFLFGYGDGGNGPSEEMLERLERMKDCDGLPKVVHSTSDEFFSAVERENSGMLCRWRGELYLELHNGTYTTWAQVKKYNRKCEVWLRDLELLATLACQRNPSYQYPWIQLDRLWKLLLLNQFHDVLPGTSITLVYKDAIAYYKDIEQVVNREIHRAANACVLNSGGPSGEGDKETYVVNTQPFPRREIIDLERRFEKDDEIPPEVEEHNIPNDFIQIEVEVPPLSVTPLSACEVNRVKPKVEINPPLEPEDVYLKREEVAEFGEVFVMSNGIIKTYIDFSGRILSLKRFDKATNRWTKEAVDPKFPMNQFVLYDDVPLYWDAWDIMDYHLETRKPLNTLEMMANDTNKLRGVVEILLKINEDNYIKQDLILDAGSPYLRVKVKATWNMNRKCLKVEFPTTVHATEASYDIQSGFLRRPNHYNTSWDSARYEVCGHKWADLSEHGFGVSVMNDCKYGWAAVDGVLRMSLLRSPKNPDPQADIGVHRFSYAIMPHFGSFQEARTIQHALAFNNPLRTVLAPPQVSTNPSPGAAVVGQGEWLHLDSDQVILQAVKMAEDCGKTIILRVHEAFGGCTQVKITTGLQLASVQACDGLEEVLKEENVQEGVSWEWKDSQGTISLNLSPFQIVSLRCQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC64</accession>
    <name>A0ABM0JC64_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="1">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090312.2">
        <property type="nucleotide sequence ID" value="XM_005090255.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853210"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0385">Hypusine</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="2">
        <location>
            <begin position="90"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005090312.2"/>
        </source>
    </evidence>
    <sequence length="162" mass="17858" checksum="9279AB29B6226A99" modified="2025-10-08" version="1">MQDQNNACHKDDDFDRGDAGASLSFPLQCSALRKGGFVNIKQRPCKIVDLHSFKVGKHGHAKVSITGLDVFTEKRFQIVHPSSHSLDVPVVTRTDYLLVDIGQYMSLMDDKGHLRADLKAPDDEHGQLMRDKIAGNTDESILVTVLSAMGEEIVVGVKTDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JCQ2</accession>
    <name>A0ABM0JCQ2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101859068</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="RefSeq" id="XP_005090678.1">
        <property type="nucleotide sequence ID" value="XM_005090621.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859068"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="32"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="314"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="346"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="428"/>
            <end position="430"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005090678.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="48832" checksum="75C754635FAE79B3" modified="2025-10-08" version="1">MADHRENGTVPAKMKRIGEHRPVTVVLGTQWGDEGKGKIVDMLGVDADLCCRCQGGNNAGHSVHVQDKHYAFHLLPSGVVYPSCKGVIGNGVVIHLPDLFKEMNRNKIEQLEERLVISDRAHLVFDLHQQVDGMQESGRGQKSIGTTKKGIGPTYSSKATRNGLRISDLIGDFDKFSEKFRHLVEHYKQMFPEIDVKVDEQLKVYKDLRERVRPMVKETVSYLHTAIKENKKILVECAQSTILDIDFGLYPYVTSSNCSVGGVCTGLGIPPHMVGDVFGVVKAYLTRVGAGGFPTELLDDQGKLLQERGGEYGVSTGRLRRCGWLDLAMLKYSNMINGFSGLAVTKLDILDVFEEIKVGVAYILNGQRLNTFPASDDDLQNVEVEYLTLPGWKVSTENARSFSELPPDAQHYIRTIESHIGVPVRWVGVGKDRDSVIPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE38</accession>
    <name>A0ABM0JE38_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-related protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091585.1">
        <property type="nucleotide sequence ID" value="XM_005091528.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857926"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091585.1"/>
        </source>
    </evidence>
    <sequence length="717" mass="82492" checksum="79D9DB55BF5AC828" modified="2025-10-08" version="1">MAGVEESDETNVFSFKDEKIVPDPFFDYPQNLREERVPLVIDNGTYQCRAGWATQESPSLVFKNIMAKQKGKKTQNEIETQIGNDITNVEVVKWILRSQFDRNIVTLFDIQEQVFDHIFSHMGINTEGCVDHPVVLTEAACNPTYTRQLMSELLFECYHIPQVAYGVDSLFSLYYNYPNAESANALVVDCGYQATHLLSVLDGRIQPEHCRRVNIGGGYVDWYLQRMLQLKYPCHVAAITMSRVEEMVREHCYFAKEFSSDLAAWEDYDFFEKNVRKMQLPLAQVLNKQLLSSEQQKERRRQQISRLQEVNARRRLDKLQADEATLQKLLEVQDLILTADDDAFVTALAEVGLRRVEDLQEHVDKLSANIQRAKAKILGQEPAPIESETKEPSFHLLDIPDEMVTPEQLAAKKRQRILKSAREGRQRALAIQREKRRLEWEEEKKLEERRKIDFSGWLAEVRTKRQKILDARSARRQRKSDMAKRRTFASQQRMRIISQLAAQPSKKGDNFGQNDADWDVYKEINKDGGTSDSEAEEEKLEELETLLKVHDPEFQKEMDVGGLSGELSLAESYRLQLGIERIRAPELLFQPSVLGLDQAGLAETMEFMLNRLEAEKQDRIVQNVFLTGGSANLKAFKDRIDWELLQMRPFQSSYNVFCAANPSLDAWNGARKFAMSPLLTAGSITRKDYEEMGEGYLREHVAANKYFPNPLPAAQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JFW4</accession>
    <name>A0ABM0JFW4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC101848181</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005092756.1">
        <property type="nucleotide sequence ID" value="XM_005092699.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005092757.1">
        <property type="nucleotide sequence ID" value="XM_005092700.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848181"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="10">
        <location>
            <begin position="597"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005092756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_005092757.1"/>
        </source>
    </evidence>
    <sequence length="916" mass="102383" checksum="1BD2CD1D93ED40FE" modified="2025-10-08" version="1">MATSSIQGIVHVVMLVAIIVFASQYHQLGLRYEELLQACKGGHSYKEYELTENRESSFKPRRPVEESGSKYHTRSEDLLTSSSAVEPGLGTRVSQMDLSVDVYQGTEKIQLGTSQLHYISQSPLNSDQIVFHATDNFLSTSKHTKLQDKETVSLDSVTSVVDVPVTSEPEQTNPVTSLDLWEHVKTQPTAPASGSDSLTVSFVFSSSSLTEQQHLLKNTEYINRNVFTSGPRVTADDSLLNIDDAAKADIVLSDASVDSIITTPTSISLSQFEAHLKSSQKFENFGSTELHDSDFDPLYYEEDFESDSYLDDYVNGVGENRINHSWEDSEAPVKEQLSGFDECEQTNSQSNTKFDYCDTQTYKRPSFSKKMLKYVEVLSAADREKLGSEGTSVWCSDLDRSGSSCHIQNLCYNTAQHDFVFLKSDTSIIEASSQEFYEGQISLSLSAIPDHNAYIFRPVTIPGKSVNEFSVSIMRKTTFLMSRFKPDNIMHVFHDDLFPLIHTLDSMKFQRRKRKFDVVIMFADHYDEGDLLPLYSSVSTESPITLWKSNFPSDLVCFESVYLGLSNKTLWYQYGFSVPQGPLHYIDKFATGVNVYRAARYAAQDLLSDCIFCSSGSYLVLLSRKDTRLIVNEGELILAVARATKLKVMSVSLETHSLAELVTIVKNSKGILGMHGSLFSLAAFLPPGSVVIELFPYAVNPSKYTPFKSLCELGGYSLIYRSWTNPSRDNSVPHPGWPSDVGGIHHLSPEAQQEISSQTEVPNHLCCEDPSWLYHIYQDTVVDIDSVVTIAASALSQAEVFANSSRMSESVSGQDSIIPGAVSSLLCNLVDNSFTLSWTPPWNVEFVSHQTFTYHLVFQERGTEMVHDKELPSSVTKYSLQHKGNHREAEFNIWLRAVFDGTRKGPPSFVTCKVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGY2</accession>
    <name>A0ABM0JGY2_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101845906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093436.1">
        <property type="nucleotide sequence ID" value="XM_005093379.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101845906"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005093436.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="57633" checksum="ACA643FA567FB090" modified="2025-10-08" version="1">MPQIVAAGGSGDSASKSEYKDKDKPTQIRYSNITAAKAVADAIRTSLGPRGMDKMIQASNGDVTITNDGATILKQMQVLHPAAKMLVELSKAQDVEAGDGTTSVVVLAGSLLDASSNLLERGIHPTAVSESFQRAAVKATEILESMVTPLDLNDRESLLKSASTSLNSKVVSQYSSILSPIAVDAVMKVIDPATAKNVDLQDIKIVKKLGGTVEDTELIDGLVFTSRTSGAGGPNKVEKARIGLIQFCISPPKTDMDNQVIVSDYAQMDRVLREERAYILDIVKKIKKANCNVLLIQKSILRDAVSDLALHFLAKMKILVVKDVERDDVEFVCKTIGCRPIASVDHFTPENLGTAELVEEVQTGSSKIVKMTGIQVPGQTVTVLIRGSNKLVLEEADRSLHDALCVIRCLVKKRALIAGGGAPEIELSMKLMEYANSLSGVEQYCFRSFAEALEVIPFTLAENAGLNPIATVTELRTKHASGERTAGINVRKGAITNILEENVVQPLLVSISAIQLAAETVRSILKIDDIVNCMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ86</accession>
    <name>A0ABM0JJ86_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855243</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094896.1">
        <property type="nucleotide sequence ID" value="XM_005094839.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855243"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005094896.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15851" checksum="1178BF7C56450275" modified="2025-10-08" version="1">MDGTGIFEGQVYCTGCTLILPDLTFLTDILLNVSAGVTAGQEKQRLLREHYPAGKDNPHDFKIIIHNTVTRQEIVMIDSRELEEYCADLADDIELHIRTNSQTEIKPAQGSNPQCLGGFNLKQQQQQQQQQQEQQQPQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JKL7</accession>
    <name>A0ABM0JKL7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101854490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005095911.1">
        <property type="nucleotide sequence ID" value="XM_005095854.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854490"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07064">
        <property type="entry name" value="AlkD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.290">
        <property type="entry name" value="ARM repeat domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1660.10">
        <property type="entry name" value="Hypothetical protein (EF3068)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070">
        <property type="entry name" value="ARMADILLO-TYPE FOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070:SF1">
        <property type="entry name" value="DNA ALKYLATION REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005095911.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43194" checksum="90FCFE81AFEE0680" modified="2025-10-08" version="1">MLRSGQAALSPALNSVRRSARRSGSSIVSTDVNGHTRTPNSNKRNSLASKRKLANDLPSSEAKGKRQSRALKDAQSGPSTPKRTSTRQKSVSDAPPARKSLASTERKAVPVKKLSEKELESKYEKRLADLRAHPNNIWGTTDVFRTLCSIFEHARNEANAVRWAKYMRDQFPFFGMTFPERKALCTDLWSDVDKLSSADLRTLVCQTWYSPEREFQYFTVDLFEKYILRIYADDVQAHSSLPVQTLDFVHQFVSCGKSWWDTVDPLSTTVGKLVRKFPEELLPVMDKWNVSSCRWTVRVSLIYQLHYGKDTDEDRLFRYCLKVAHEEEFFIRKAIGWALRQHFRLSPVAVREFVKKNKNKLSALSMKEALKHDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JLQ8</accession>
    <name>A0ABM0JLQ8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC101863098</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005096637.1">
        <property type="nucleotide sequence ID" value="XM_005096580.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101863098"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF8">
        <property type="entry name" value="PROTEIN TWEETY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005096637.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="57883" checksum="89D0B1105E2430A0" modified="2025-10-08" version="1">MEGDGSQEKYEKIWLSNFFHSFPHWNFAFSTVNSTFDPESDDYREAAGLWGLVPIAVCFMLWLVFLIYFVFRCCQSQAQAKPRPSACPSVFTGICILIVVGLLGFGFYENEKAHRGVQNCRRAVIDANTTISLASNRVQSLDDIAEEISTKVSDDLEKAVSQLNSTALAKAIKLINHIRTEATSVRGYVDKINIEDEQGGLDDGIKLSGDIEYYRWMVNILVYCLYIFLLLLAFIGLLIKSKALLIVSAALAVIFSLFIWITTGVYLSFSVALGDLCHDPDSYFLSLAKGSAQEGAIRAYILCDDPTKPYQNEIQDALNSVSLAAKDLNDTVRLAQPFHIPGLEGPVKEMRQNLQFATGNLSTLLTDVGMCSALHDDYIDALDAACISTLSASAFLALISCVVAIACTVIIFTLSCAWRQYVKINVRAEYVPVDDSDPFLPRPPLYESDYGTMGHSTPRPWSERGTLQHGNMNAADDQVLMMTHQHPLPIDESPPPAYYPGKYIRQYADSAPSPGSVRHHPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMM0</accession>
    <name>A0ABM0JMM0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847581</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097241.1">
        <property type="nucleotide sequence ID" value="XM_005097184.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847581"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="296"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005097241.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56708" checksum="900BA147523CD171" modified="2025-10-08" version="1">MGNKSSTILRKISTPHNHHQGQSENDAVLEESRKQSQQHYNVSLIRLFEKLELTADGDNVHPGELSKATFENAFHGPLHIFGKLIYLQMVSSGALHRERITREQFVKAGKEILKMHGEKALVKYYFHLFASGKDHLTNEDAKQMFEISFALTLSLSKILHKEDERDERVFCAMVTSLFGIKTEVKLEEFSTWHRDSCPELFQHVHNWVYHILTGSSLPEELDNCRVPMLDAVTNANNSISMAVLWLLSIVLPPAYTKLKAQKKSSAEGPSASLAASVAANNFSSGAGAGEYSVTKDPMWTSLLLLRKMARLPQCESWKVLYNSENHGMSSNRFSHHVASYHAANVTFFNFEGKNQYCLALDRGWREGCGKFGGEDCRLIQLLPVYRVIQSGENMVKWVESSKSSSQGIFVGCDGKAEVLRIPKDFDTISHYGVSCQLYRVEVWGCGSDDALEAQRIQKKWEAGAVSREQGRKLRPYGESWDDTPDKQLLQWGGVNVGNHSYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNF9</accession>
    <name>A0ABM0JNF9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101855640</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097799.1">
        <property type="nucleotide sequence ID" value="XM_005097742.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855640"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045546837" evidence="1">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005097799.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14357" checksum="DF968F12AAB40869" modified="2025-10-08" version="1">MAVSMFNALCALAIMLFLGSQFCWTQEEEPECVCSCIKAAIPEDKAEREEFVENEKKKIVKELHVDKKNLSSETRKKSSAVDERPSARSVGYLGIAMLTLSAGIVLVFDLDYVIKGVHSIGTIIKNKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ43</accession>
    <name>A0ABM0JQ43_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pedal peptide 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2006" name="Cell" volume="127" first="1453" last="1467">
            <title>Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Edwards J.R."/>
                <person name="Puthanveettil S.V."/>
                <person name="Kohn A.B."/>
                <person name="Ha T."/>
                <person name="Heyland A."/>
                <person name="Knudsen B."/>
                <person name="Sahni A."/>
                <person name="Yu F."/>
                <person name="Liu L."/>
                <person name="Jezzini S."/>
                <person name="Lovell P."/>
                <person name="Iannucculli W."/>
                <person name="Chen M."/>
                <person name="Nguyen T."/>
                <person name="Sheng H."/>
                <person name="Shaw R."/>
                <person name="Kalachikov S."/>
                <person name="Panchin Y.V."/>
                <person name="Farmerie W."/>
                <person name="Russo J.J."/>
                <person name="Ju J."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="17190607"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.09.052"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098921.1">
        <property type="nucleotide sequence ID" value="XM_005098864.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856965"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040384">
        <property type="entry name" value="ORCKA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33864:SF4">
        <property type="entry name" value="NEUROPEPTIDE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33864">
        <property type="entry name" value="NEUROPEPTIDE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00029">
        <property type="entry name" value="GASTRIN"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046490464" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005098921.1"/>
        </source>
    </evidence>
    <sequence length="1009" mass="110433" checksum="1070E9AA8858B2A5" modified="2025-10-08" version="1">MRTAAICVVLLLCTARSQCSDQQSQNEGESQPANEEKRKFDRISSLSGGFGGFGKRDGEGGSTEETGDVEGKNSEQTTEEASEAGDVTDEANSSMAKRGFDSISSVSGFGGFGKKSGEKRRFDSINSSAFSGFGKRPFDGIDSVSAFSQFGKRPFDGIDSVSGFSQFGKRRLDSIAGSSGFSNFGKRRFDSIANNNAFSDFGKRRLDSIAGSSGFSNFGKRRFDSIANNNAFSGFGKRRFDPIANNNAFSGFGKRRFDPIANNNAFSGFGKRRFDPIANNNAFSGFGKRRFDSISSNGQFALFGKRDASDGPALEAPSESEFGPEPRELNGDEKRAFDRISGTSGFTSFGKRSFDPISDSSFVGFGKRPFDRISSSGFRGFGKRPFDRISSSGFRGFGKRPFDKISSSGFRGFGKRPFDRISDSGFVGFGKRGFDSIGDSAFTSFGKRPFDRISNSAFSAFGKRPFDPIASSQFIGFGKREDELMEQNSENENVLADSMDGADGDSSKRSFDRITDSSFRGFGKRQVGDTGSDVEKRRLDSIAAGSRFASFGKKDGQESDKRRFDPISGVTSFGTFGKREKNDDEVSSEKRRMDSIAGGSSFSSFGKRVPNSEVTENANDNTSSTSEKVQSRRKKRDTSKANKEGDVTLSLVDNPEEKQTETNKVSKRRFDSIDTRSAFRRFGRAFDKISSLSSFRNFGKRDDETDDDSNNELLSDVRLAAKRRLDKISSGSSFREFGKREGLKDTDDALDGNDVGKRRFDSIAPSSGFGGFGKRRFDSIGDGLSGFRTFGKRRLDKIAGMSRFGGFGKRRFDKIASNSAFAGFGKRRFDSIASSSPFSGFGKRHFDSIAGKSAFGGFGKRKFDSIAGTSAFSDFGKRRFDAIDRASAFRVFGKRNSALGEGDNQSADNLLAWAMLDALLSKPETSVASEVSKRRFDPIEHFSMFRRFGRGLPLQTPAVADTFSDFPQESTDDILDDLSEEESEELVELLISLARKMAESDVDSSDVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQD9</accession>
    <name>A0ABM0JQD9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101860975</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099102.1">
        <property type="nucleotide sequence ID" value="XM_005099045.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860975"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005099102.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17590" checksum="E32DBFD4C3D7840F" modified="2025-10-08" version="1">MITHSRPEAAVYGVSDESIVRPGRGLSLSRTTLLHLDQDELSSLRGDNQYDEIDLVSECSTPCAYSPGRFLQLCDVRDDADLKDDVTIWPVSLGPSLGDGHTTRLLADQCKISVSETFLHSKPMHPARRPTLRSPRFLLPLLLCLFLALSMLGVLMTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQM4</accession>
    <name>A0ABM0JQM4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Forkhead box protein biniou</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101856898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005099253.1">
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20021">
        <property type="entry name" value="FH_FOXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047208">
        <property type="entry name" value="FOXG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="375"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="375"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
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            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="245"/>
            <end position="377"/>
        </location>
    </feature>
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        <location>
            <begin position="575"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="634"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005099253.1"/>
        </source>
    </evidence>
    <sequence length="693" mass="75600" checksum="400B72B5CEDD1375" modified="2025-10-08" version="1">MGSPQKDGVLDGPVTAVKPKGGNPFSISRVLADDFGKNFRHGLPVNSRTAQPDVSPHAATASSVFSYPHSALQHQQQQQQLLHHQQQQQQQHLPSFIHNNNNNITSEVNKSLVDSASRDAMTVFRYGDHPSDHEKSLSPPHSTRVPHITDRHTDVHTNGRCSSARRDLSSPTSSHGSPELRDSNPTDSNIITTSSTSDPAGEPRLFPFHRDHRFSPNSHFEANSQFESSNSYFNSKPPHYLQNCQYSPGSASDVHERDAQSGNRLVSSTEECGPGGRDFTERESSCGSPVSCTDSVFDKEDQNNNTDIDVDDDISDSKLDNQENGCGNEEEVKSEDGVDKEDGGADDASSTANEGEEKEEKKEGEKTEEEKKNEKPPFSYNALIMMAIRSSPEKRMTLSQIYEFITKNFPYYRDNKQGWQNSIRHNLSLNKCFLKVPRHYDDPGKGNYWMLDPSCDDVFIGGTTGKLRRRSSHSARSRLAFGRAGFPYMGMGGFPRDGHPALLPLSPFYSLPGVVKHPGMYSYLGHNLLPPAPGLDSNHAAVMARLPGIEKLLMHGMTSPAAAISAAAAAAAVSQSSLPRSPPTAASPRGPPVSNPLRQFPPPHYASLPSPLPASPFLIPGFGHLCSKSVGISSLASGPSPPTSSMHRKLDHMSENPHEGHNTSPVSLYQHLLRPFSGQGLDSGKLVTPMISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JR29</accession>
    <name>A0ABM0JR29_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monocarboxylate transporter 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005099534.1">
        <property type="nucleotide sequence ID" value="XM_005099477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860897"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF306">
        <property type="entry name" value="RE01051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005099534.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="37919" checksum="0F173D508AEA7092" modified="2025-10-08" version="1">MTSETAARAEDGGVLLSESRQGKGQCSQENDTTDDTQQSSPSGKTSSVSAEQDGFSEKLTSSPINYSQPDKKRQRQKLGCLKSFLTTCFPVENKQGRGTAGKKLFHFYLLKNSSFLCFCLSICLFTAALRAAFTFIPALVKSKGLSATDATLILSIAGVFDTLSRIATGLILDSRYLRPWRPMIYNSLIFAIALISFALPFFSSFVAFVAICGFYGIVTGAFISQKAVIIVDILGKEHMSSSFGILLLFQGIGTCVGPPLSGAFRDMFGSFDEAFYLGGGLMVVAGCLMVVGNCFLHFARRRGKQSGDRIAAKGCLMLSADPERSLGRTPVCPGPRNAWGNLRGAQTDVDAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS29</accession>
    <name>A0ABM0JS29_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iroquois-class homeodomain protein irx-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101850654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100239.1">
        <property type="nucleotide sequence ID" value="XM_005100182.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850654"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF40">
        <property type="entry name" value="MIRROR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="151"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="390"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005100239.1"/>
        </source>
    </evidence>
    <sequence length="653" mass="69146" checksum="AA0DF62388E2FC1F" modified="2025-10-08" version="1">MSLAQFPAFPAPNLPRSSPPSTQPQMTSPTSASSHRACCENGRPILTDPHTGQTVCSCQYPPAGLVSYPRPPALPPGALESVYSASAYAAAVSQGYVALGAEGSAFYTPLGTTPYDLKESAEAWRTLAASQPGFPYDPMAMYPYGPGKNATRENTNTLKAWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNRSEDGSDDVDNPEDDDDCGESRAHDVMSPNHELDITSSKPSSPLLSPASDRCGENNNKTYKERIIRVDEDEDDCDDDDDDDDNSRDSFQNRRLMGSDYPDHPRPPRSGSRDRSPLRPVSRGDSRDGLSADAKNRSDDDQHQHHHHHHHHHHNSHNERRSPGLNSSNLGTSRTLLDNPGSSVVSSSSSSSKAGSSQSPSDISSATSSSSSSSSSKVASTSDNPQSAPVTKPKIWSISEFIKTTSSSSLTSPFSSSSSPSAMSSSISSSLSTLPSPSALNRSPFMSPSSVPSSVSPQRPIPNQGFLFLPPGATAHWPAAAAAASRFAGLGGAYPLSLTHSTLSYPYNLASPGAAAARAGLEAVHAQAAQLAARAAAAEGGARDGGGASAAAAAAAAAEKLASLHPPFPRIPTSALFSPARDLDGVRPPVMPPPPRMVVDSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTE9</accession>
    <name>A0ABM0JTE9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101859493</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101859493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005101054.1">
        <property type="nucleotide sequence ID" value="XM_005100997.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859493"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101054.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19740" checksum="C67A23E5EB74EE6E" modified="2025-10-08" version="1">MGLGETSLKWRLAIMLQFLGFLLGIAAVSSTYISAAEVIPNREHHVGFWDICFDTQTYGCQDYPEYLSSIGEDADWVYACRGLVVVSLIAGVFGMLVSIYLAYMASGIHMASLVTAVLNFLAVVSGLIGSIVFLVNSLQILKDQLQMDVYPSWSFAVIIIGLSFYFLAAITHIFELCTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTU6</accession>
    <name>A0ABM0JTU6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101849135 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101338.1">
        <property type="nucleotide sequence ID" value="XM_005101281.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849135"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005101338.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22996" checksum="4CFF27778B96ECE4" modified="2025-10-08" version="1">MNAGRGNRNNINQIDLVVPQFVPNDFADDSPTERDPGPGYDGGYIAAGWRMIKSLVVELFPFLHSREVFFLSLNRTQQCILENPCTSVFYSFIAVFGVFPMLFFLLTICSVFTLSVVGFVCCQVVMFCLAATVFTGVMFFIVSTSFLIACSCGATIHTFYLWRWMKNYMLQHGKEILIEILDNAGAPGLWLKNYLFNEEPRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JU62</accession>
    <name>A0ABM0JU62_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized aarF domain-containing protein kinase 5 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101860748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101564.1">
        <property type="nucleotide sequence ID" value="XM_005101507.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860748"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF28">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="168"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101564.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="68547" checksum="D7394E21DDFDF87E" modified="2025-10-08" version="1">MIVYSNFRHMWQPVLSLCRPRNAAKHTTFCTVKSHFSSLTPRKPQRFGKLSTTAAVLGLVSVCGAVSYLMLDSRDQRKITVFAGGVRRFMRSLHIGLALSADYKWTLYNVDEESDEYAELLKACHKRSAERILAGCLQNGGLYVKLGQGLVSMNHILPIEYTSTLVVLQDKALSRQPHEVEQLFEEDFGKKPLEMFAEFEDEPLAAASLAQVHKAKTHDGESVAVKVQYIDLRDRFSGDMKTCEILLKLVGWIHPKFGFSWVLQDLKQTLRQELDFENEGQNGEECAKDLSHLKFIYVPKVYWSMTTKRVLTTEFIDGVKINNLEGIKDLGLNLQDVDQKLVQSFSEQIFLSGFVHADPHPGNVFVRKGQDNKAELVLLDHGLYDRLNGEHRRALCQLYQAIIMKDELAMDYNSNLLGVQDSLIFAIMIMQRPVRMKSRRLFDIKPPTREEWVLMSKEDKAMWKEKFQEIHDRVLTIMKEMPSPLFWIFRNLNTIRAIIRDHGNTVDRYGIMARSAIRGSHRDSASSGTFLTVLQGWWHRCLYDYRVWRENVTHKLLMFLTLNYLRFLQLVGKAPSLEELQAFTNAEKKRFDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUS4</accession>
    <name>A0ABM0JUS4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromatin accessibility complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101859253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005101985.1">
        <property type="nucleotide sequence ID" value="XM_005101928.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859253"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22924">
        <property type="entry name" value="HFD_CHRAC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005101985.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12006" checksum="5B1BCDA9C8B284E2" modified="2025-10-08" version="1">MADKASNANSNTLPLSRVKTIMKSSPEVSSISQEALHLTGKATELFIQALAKFSYQQSDSKSSLEYKDLAEIVNSEDTLQFLHDIVPRKVKAKDYLKMLRQIEDKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW04</accession>
    <name>A0ABM0JW04_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101849704</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_005102822.1">
        <property type="nucleotide sequence ID" value="XM_005102765.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849704"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 18" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="71"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="252"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005102822.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46884" checksum="853276E91AD57A7A" modified="2025-10-08" version="1">MSYNSTEQDRDRSQTKGPAEPEYLPEADGVIESNYDGVVDAFDDMNLREDLLRGIYAYGFEKPSAIQQRAILPCIGGQDVIAQAQSGTGKTATFSIAILEKLDLNMLSTQALVLAPTRELAQQIQKVVLALGDYLGAQCHACIGGTLVREDMRKLESGSHVVVGTPGRVFDMINRRAFNTKDIKMFVLDEADEMLSRGFKDQIYDVFRHMPNEIQVILLSATMPADVLEVTQRFMREPVRILVKKEELTLEGIRQFYIQVEREEWKLDTLCDLYETLTITQAVIFCNTRRKVDWLTEKMGSRDFTVSAMHGDMNQNERDLIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDIRVLRDIEQFYNTTIEEMPMDVADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JW64</accession>
    <name>A0ABM0JW64_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101857497</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="RefSeq" id="XP_005102934.1">
        <property type="nucleotide sequence ID" value="XM_005102877.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857497"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="25"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="201"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="314"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005102934.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="62486" checksum="B52D75FBF0FCDFE2" modified="2025-10-08" version="1">MSSRDDGAMAPHVVETIQTSPFDGQKPGTSGLRKPVAIFQQPHYTENFIQAGLISGLGDKVKGSCLVVGGDGRFFVKEAAQLIIKIAAANGVSKLVIGQHGILSTPAVSHIIRKYKLDGGFILTASHNPGGPKGDFGMKYNTHNGGPAPESVTNHLFELTKTISEYKIVPNVKANLDELGSQSFQIQGEQFTVEIIDQTKDYVEMVKDIFDFDLLRGFLKTKRVLINGMNGVTGPYIKKIFIEEFGLPEEMCLNCIPLPDFGGRHPDPNLTYAKDLVDIMKEGRHDFAAAFDGDGDRNMILGHSAFFVTPCDSLAVLAAHLETIPYFKRNGVNGYARSMPTSGAVDLVGKKYGKEYFETPTGWKFFGNLMDANRISLCGEESFGTGSNYIREKDGIWAALAWLSVMANTGQSVKEILTSHWSTFGRHYFSRYDYEQVSSEAGDKLMEGLTKLINDPKTVGMTFSDPTGKSYKMAACDNFEYHDPIDGSVSKNQGIRLMFEDGSRIVFRLSGTGSSGATVRLYVEGYEQESDPNSYLQDAQDVLKPLITIALRTSKLKELSGRDEPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWX2</accession>
    <name>A0ABM0JWX2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibroin heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103482.1">
        <property type="nucleotide sequence ID" value="XM_005103425.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101864317"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103482.1"/>
        </source>
    </evidence>
    <sequence length="782" mass="70995" checksum="2189AAC71859218A" modified="2025-10-08" version="1">MSSVSAGGFGARSGLSRSGNIVLGADNINARSNADLTLSSGLRAGPAIGGFGDQSGLSRSRNIVVGADNVNARSNAELAFGAGDGSLRGGFGAQSGLSRSRNIVVGADNVNARSDAELAFGAGDASLRGAVGQGGLKLVYDSRSSGPSSLDGAATYDGLLLTGSRDSVASGYSGNPGGFDLGNSGVGSGVYSNNGRFFGNGRVMPSGGAFFDGGAAGVMSGGDLAFSNGPVVGGAAGSSGGVLLAGSTGGRVGSGVVESPRRSFTGLGSAGALSGAGYTDAGTVGSSGSSLAASGSVAGAGVGTGSRSLPRGLVLSAAPSSDLVGAAGAATATAATLANGAGVVVSSVPAAAILSGTDSGVYNGAGARGASLSAAGARGASLSAAGARGASLSVAGARGASLSAAGARGASLSVAGARGASLSAAGARGASLSAAGARGASLSAAGARGASLSAAGARGASLSAAGARGALLSAAGARGASLSAAGARGASLSAAGARGASLSAAGARVASLSAASGAATAASAREGVMSGGTGADDYTVRAAGTVAGTRAGAGPSVSSSGLGAGSGRNYGSAASVAGSGAAAAAGAYDSPAVRTSGSVEASAAAGVYNRASSGAGSTGRSGSTGSTGGSGAAAVAGSQSAAAGGDYVAGGATSSASQAAGKASGASANGSGRGSMSVSRSGAAAAASSSSNSNVNGNINISNNNGNGSGTNAGKDSTTAYGTGRQGNGSNSSPGTGSNRVGIVGVSGGASGSASNQLDSTGSLVIKKDDETLTYKFGGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXW8</accession>
    <name>A0ABM0JXW8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101860428 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101860428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104135.1">
        <property type="nucleotide sequence ID" value="XM_005104078.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860428"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104135.1"/>
        </source>
    </evidence>
    <sequence length="828" mass="94782" checksum="2AF0307AD7DF6728" modified="2025-10-08" version="1">MASLSHRSHRQRQKPMSYGLRMLDAALQKHKAPTTHADQQSSSTSKFDPFDVNPEDPFDVNQECPFDAIPESPIDHVNPEYFVGGSKSIISKAQAQLYEEDLDMDDDGDIDYIPQPETDSESEVEIPMQDTGTSPPECGSQAESPNAESKQNEPIDKKKPKRLCKYCNTWNSHLTRHLKRKHKDEEEVVLALKLPKKDQEKAFGALKREGIFMANMKRLESDKSAPLIRERSQGVGDTVLCSGCRGFYDAKSIFKHKRLCEKNLSDLSKTIKLNELSDNATLAGVDSDFKENILDRFRKNEVGEICRTDFVTLLFGKKQWAKSVKKERSITMSEMRVLANLILIFRQECGDEKASGHDILDYRWFDFLENAIKKMCAKDCGQDKAGLKVRIGFVLKRAVKVMRGFFVMKGDTEKEADMSRFLSVLELNWDFIFFTSQVECEQRRGGLRKPSAMPDEEDISKFRTFILDAMKNHLEQYELWDKHTFVKMRNLVVARLTMFNARRGGEPARLTLNEWKEALTGAWIDPNLVEKIDDPMEKHLIENLKLAYQSGKGSRKMVPVLITEDTLEPIAKLLSERSNCQVSKHNVFLFPNTGSSLDHASGYHCLKSVVDICPSLNKPNLLIADKFRHRVSTLYAQLELPEEQRDIFYRHMGHSETINKNVYQCPLAVREVTQVGKFLINNDGRGSLVQTNTDQGGTSYIRQTCETDNLTNEVTTQEDVCQNVSQADEMTLEEDAGQNELAQRAESVSKRARRYTRWTEEDCALIKTHFKHYITDTSNKGRLPGKKEVLAFLEKYKILEGHNDKISLVKSKVFNEKTKYRNGKFKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JY36</accession>
    <name>A0ABM0JY36_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flocculation protein FLO11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101849863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005104262.1">
        <property type="nucleotide sequence ID" value="XM_005104205.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101849863"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
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            <begin position="214"/>
            <end position="224"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="270"/>
            <end position="282"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="437"/>
            <end position="469"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
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            <begin position="594"/>
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        </location>
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            <begin position="620"/>
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        <location>
            <begin position="647"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="678"/>
            <end position="694"/>
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    </feature>
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        <location>
            <begin position="695"/>
            <end position="712"/>
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    </feature>
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        <location>
            <begin position="759"/>
            <end position="790"/>
        </location>
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        <location>
            <begin position="821"/>
            <end position="834"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
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        <location>
            <begin position="895"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="928"/>
        </location>
    </feature>
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        <location>
            <begin position="1100"/>
            <end position="1111"/>
        </location>
    </feature>
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        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104262.1"/>
        </source>
    </evidence>
    <sequence length="1400" mass="154482" checksum="BB6B0C1EF1144898" modified="2025-10-08" version="1">MDLSVRKRRHPEELTSPMSSSNQETLSREHVAAPACHQGMPDLSALRPRHRRKGIPVKMTLSNRTTVYPLYKETGIEQRVPRPCAESQRMPQRRVEQLPPHVSSNQHLLQGYIDTHDVTRGNQHNVSEKFEASAPEQRENQRRKDTPTYGYHGSQNTQSILSGTKEVAQKLLDDQSHRQPISYLNTKTKVISSKKRRESGRICDQGIHSRRQPLPQTLGPQSASLPPPTLHNIHQPSQTPPALHIDLSQPSPPSLTLPIDLSKPSPPPSTFQTQISQSSRPTLHNDPPQPSSTLPILPIDLSQPSMFQTPSTLRNIPQPFQTPPTLPIILPQPPSTSTTHHIDTSRSSTHSLPPRNNPPESMPPPLPPILQNHPAHSPSPSSALPIDLSRPSTPLSTLHNDNPQSSPHPPILHNSPFQSYPPAPQSTFHWDPPKSYPPNQYKTAYQSSPTTIHNNPPQSSLPTLQNNPPKSLLPTIHNNTYQPSPTIIHNNPPQFLTFPPSQYNNTLQIFPPPLSFPRHSHPPKSSPSTLQNIHPQFSLPTIQNNSSHSSLPTIQNNSSHSSLPTIHNDSSHSSRPTLRKNPPKSLLPTIHNEPPQSSTFPPNQYNNVLQSSPPPPPSTLHRNPSKSSSFTLQNNPPESSLPILHNNPHQSSPLTLHNNPSQSSTFQPNQYNNVLQSSPPPPPPTLHCNPPKPSPSTIHNNPFHSSPPTLQSALHCDPSKFSPPNKHNTHQYSHPTLHSEPPQPASSPPTLQALPPRTSHPTSATVSSSSLPSRTLQENASQESTTTSQSDDMFSFSESCETLHNITWEVVWETSPKPDSRASQTDSNISITGTESREESGSGPNSLTLQDAQIHSEDKTEISSSKIGLTLSDVGKSPTMPGRAGDNDQSTSGYDSKESYKTAHENELPKNIPTSKTDNQIPSTSGVNIYTTSEPRVSLDASAGTITRSSTRCDHLTTNSWCQEKRCRKNSGSGQTCKKVQRQGTLASRVLRLEREHEKLLEDSSLMWMGLEELRKQLYNLSRTRTEPSEESSGPPCLSPQEIIHPLEDKSGCSPPNNDVAPSDVRKSPTMSRGTSDDNKLSTLSHNGEMCSSKADNDNPSTTSSSTPSSTQDDKRCSTSGLNGCMTPESTAGCVVSPNAGINANSHNISSRADSDIPETRTEGSSGEPPVLSPQDIHFHTGDKPESWFPTKKNTTSIGDVRKLPTRSGLDGDDLKLSASPFAGHMASGQRTNRDTRVGIGSRLSKMYVHLKQPRNRQNESSQRSNKKKQRRTLDSRVLRLEQEYEQMLKDNSLLNEEVAGLWIEVRHISRTRAEPSEKSSNGLIFLNPQVPHFNPDDNVDHWSKIIEPVLDAVRKPPTTSHKDADNKEQSTVIFNGEIFMNRDDNYSLTRLQSQKTTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JZU7</accession>
    <name>A0ABM0JZU7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">ATP-binding cassette sub-family E member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC101857740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105419.2">
        <property type="nucleotide sequence ID" value="XM_005105362.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105420.1">
        <property type="nucleotide sequence ID" value="XM_005105363.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857740"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03237">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="81"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="353"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005105419.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005105420.1"/>
        </source>
    </evidence>
    <sequence length="610" mass="68949" checksum="A806E44F7D3F3FFC" modified="2025-10-08" version="1">MSKNKKNKTEEANDVLTRIAIVSTDKCKPKRCRQECKKFCPVVRMGKLCIEVTPTDKIAFISEELCIGCGICSKKCPFEAITIINLPSNLQRDTTHRYSANSFKLHRLPTPRPGEVLGLVGTNGIGKSTALKILAGKQKPNLGRFTDPPDWTEILAYFRGSELQNFFTKILEDDLKALIKPQYVDQIPKAVKGAVQQLLDKKDELKNQMEVCRQLDLLNVRDRNVEDLSGGELQRFAIAVVCIQNADIFMFDEPSSYLDVKQRLKAAQAIRSLIHPDKYIIVVEHDLSVLDYLSDFICCLYGVPGAYGVVTMPFSVREGINIFLDGFVPTENLRFREASLTFKVAETAMEEEIKRMCRYEYPNMKKKLGSFQLAIDGGQFTDSEIIVMLGENGTGKTTFIKMLAGRLEPDDGGEIPILNVSYKPQKISPKHQGTVRQLLHERIRDAYVHPQFVTDVLKPLQIEPIFDQEVQNLSGGELQRVALTLCLGKPADIYLIDEPSAYLDSEQRLHAAKVIKRFILHAKKTAFIVEHDFIMATYLADRVVVFEGKPSLDTKANTPQSLLNGMNSFLESLDITFRRDPNNFRPRINKLNSVKDVEQKKGGNFFFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K0B5</accession>
    <name>A0ABM0K0B5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101853723</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101853723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005105750.1">
        <property type="nucleotide sequence ID" value="XM_005105693.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853723"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="6">
        <location>
            <begin position="143"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005105750.1"/>
        </source>
    </evidence>
    <sequence length="692" mass="77561" checksum="69A5E8DBD98306F9" modified="2025-10-08" version="1">MESDFAKSDNDKKVVVSYEDYCDLVSVEHECNTRADHMNRTKEEIKKLETEVEKLKMEAQWCFDERGNRIIATAEQQALEISQKIMEHPQLMEETQMESYTQETLERAIELVKGKHMSLNGASKTFNIPYSTLGDKIRGRRPVKAQPKTVLSIEKELKLVAWLQESSKLGFGRTREDLKDAVKKILDAEKRTTIFKDNRPGKDWFQAFFKRHPHLSLSERALQVLGKEQAVVTRDSLNTWFQEMKEYIDQQDASLLTSPDRIFNAGESGFSVCPKTKKVISETGAKHVNALTSGSRQQVTTLACISANGRYLLPLLIFPYKRDPPYNALEGFEQAFFNKSDNGRITEGVFLSFLRDIFIPHLAREGMKRPVVLFVAGHSSHSSLEVSDLCSENGVILYCLKAHSSHLTQPLNQAFFEAIKPAWQEEVRKFVTDNMKPVTLGTFAGVLKKAWTTAAQPETATRGFKKAGLFPYNPDVVLTSDKLKPSCTFTGSPAPTFHLLPTSSPSVPPTSSASVPSTSSPSAPSTSSPFPPPSSSPSAPPTSSASAPLTSSASEPSTTSQTRHHRLKQIFSMNFKLGEEKVDLFLKRYETGYDLKIDPDYNMWSSLMYDIEQLAPPPLPQPSAGALKPQTITDKVLTLQSCSKNKGVKRPQPPVPQCIGGNDYKEMILTKKRKAEEEQQQKEERKKQSEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K1M8</accession>
    <name>A0ABM0K1M8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101862443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005106642.1">
        <property type="nucleotide sequence ID" value="XM_005106585.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005106643.1">
        <property type="nucleotide sequence ID" value="XM_005106586.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862443"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="623"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005106642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005106643.1"/>
        </source>
    </evidence>
    <sequence length="852" mass="88805" checksum="E80D10BE373754B6" modified="2025-10-08" version="1">MRSTRSPFCNRTSLPGRHYSFSTFVVAATMENHEDYLDALTAYARTPESDVPPVLDQYLNGVAKNGETLFQWPLLKPLIVGKMEQVIRELRQGLSTESIPPRPNVENVRFDVMHARIMDALHKFNGAPFTIQRLCELLVDPKRHYKRSDKFMRGLEKNVLVVSTVDPFGRKVVSESSNKPLVNGMDINGSPFSTRDPHTSTPLPPVPGWVTSTVAMASRSQNSPSQDSSDHPRPTSQVSLPEAGITSNGVSGGLVSSLYADQGEQPLSVHAEEVVEETVVTMDTNEVANVATDAGESLAEEEEEDEEMGGEDTNASSSSSSSSSSSEELSATETSENGAPALSPKVSSSTESPPQSRPWAAIADEGENEKLTEGESPSKKSRTATSPDASDTRESQENSDSSSSTSPPQSSPPSSKLDEVSSPSSVKQDSSQGQPAAAGAALSWQSISTSPDVADPPEASGSTCTCSTNVPTQASSEDSFGFDTVTTSSSTVAEEETVTDSTTGETPDAVEESVGSDNANESEATLSTSSSSSSSSSSLSESKNTSGPESLVSSAPASDEGQVCSSPPKSDPSVCETVCSTEAVASSTDTPLTAYSSSSSSSSAQSSMECDSVAGLERLVGSVEPSSVSSLSSQPAFSQPSSSSSSSSSVPPSHPTNVSDSGLPTQSGDPASPPKMEMSEHIESEAECDKQTDSSDSASDSSSQSCLPQQTTEDETMEAAVSDKVTVVMVSEPEDSGHVDSTADTTSENVEVGSDSTGSDAVDGELSTVSSELGGGDCKAEEGEEHSLSPPSQRSSSDSLGFEVCGDSLNKSVGEDKEPEDESAAVEKASESSEDVSQMDSEDPGHEPMDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K456</accession>
    <name>A0ABM0K456_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101858061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005108331.1">
        <property type="nucleotide sequence ID" value="XM_005108274.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858061"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01012">
        <property type="entry name" value="YcaC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005108331.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22493" checksum="F5163D79B6D3899B" modified="2025-10-08" version="1">MAAKKIGKIAFKNSALFICDMQEKFRPTIQYFPQIINVANRLLTAAQELEMPVLVTEQYPKGLGPTVSELDVSQHKVFPKTCFSMIVPDVQAELEKCSDVKSIVLCGIEAHACVQQTVFDLVEKDYDVHVVVDACSSRSLVDRMYALQRMREVGAHLTTSESILLGLLKDAAHPKFRQVQKVIWDPAPDSGLLSGFPQDGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K4I8</accession>
    <name>A0ABM0K4I8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC101855977</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101855977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005108571.1">
        <property type="nucleotide sequence ID" value="XM_005108514.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855977"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF16">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="4">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005108571.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25486" checksum="8B4000A2C7182F3E" modified="2025-10-08" version="1">MASRSRSSRTRGSSETLDLVLVFGVKKLPIHLDLLEEEGRAERLNLYHLSQAVYRETQVEPSCQKIIFRGRTLFKPNDLDTVFMNSSLSSLGLRDGDRVMVLGRKASERRDSSESKGSQDSNNPLTQLSSEVDAICGRCEQHISAVGDARDLASLKAGKKCIMGIHEESMKLLEKIDSTPAREDEDYRKQRKSLVNKLQALLDRCEDHLDKVKQKIRTLEQDGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K5H3</accession>
    <name>A0ABM0K5H3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoporin Nup37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005109199.1">
        <property type="nucleotide sequence ID" value="XM_005109142.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101862756"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005109199.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="35964" checksum="DA9E4FE743F3753D" modified="2025-10-08" version="1">MKEDSQECTYTIPCEDTVQCVEFSPFEWSYQLLAVGTSSGVSVYSCRFQEEDAEVANGIEFKRLRDFPSKSATPLAIAWSPQTSLQVLPKLMSFAVAADDRTLQIFATDMNSTHSVKVLSGHSDYVNALTFDPNEGVLLASTGDDMTCRVWSVSDGTQESIFQLTSPGMSVCWHADEPFKLMVAQKDGTIRFLSLHNQQPIMSLSCGQSPLMSADWSRHNNLLVGAVCGSEWLVFNVSVSSLPIERRPAHNEGGKHFRWSRCHESLLATCGRPGRQLKVFNTRHQQLHVSTSLPISYGLSWHLHLPLVAVGGDRAVHLWTVESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K9Z1</accession>
    <name>A0ABM0K9Z1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptor moody</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101850771</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112475.1">
        <property type="nucleotide sequence ID" value="XM_005112418.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850771"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF74">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="57"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_005112475.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="53597" checksum="468F54D87F6B9961" modified="2025-10-08" version="1">MAIDDNDPTAQPEQHNTNPGTPADNPHNPLDLTDGERTALVGILTFMGVIIALGGIGNLLVILAVVLKKKLQTVSNLFVVNLSICDFMFVTLVLPVNMYTYLADGWLIHPLICKFVGFLGYTLTGTTIMTITLIAWNRYRLVVSVSSYKQMFQPRNMAIMLAGSWLIPIICLQPAIFEVWGRFGFVPLLSSCNLDLDSSSQSFKIFLLIVRAAIPCGLIIYFYSSIYANTRASHQRLHHAACSTTSLMLQQSQRREMRLTRMMGGIFLVFMLSYFPCTVSSLIDWSKLLSKSFHMFCQTSVFLGSAINPLLYGFMNEQFRKAYYEIITCGLMYGRCKKCAKTVHDHSRKVAREDSTENHTYHNTDNQEVNTEIHHDGLVSSWSTAQQQLHSQEEETLYYAYQENSDDNDELPDHKARVSTEKVPPSVAHSRTNSINFSSNCDISQRDVSTSLLKSSESDSKLATLQDVHSPKQSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KA16</accession>
    <name>A0ABM0KA16_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 74A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101861255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112518.1">
        <property type="nucleotide sequence ID" value="XM_005112461.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101861255"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005112518.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="48915" checksum="F509D39C7A4CC6A7" modified="2025-10-08" version="1">MRPDPHTLAATYRLRLMPKKRNITLVKKPGRKQGKAKVSIDLSKQGSSSDVSTDQDSSTRDQNDQQKSTGALYIGTSCWKIDEGAEDDSISNDEDYEDDLRLESTRTVHEDLAVQTYHTMCKALCVHPLKTFQNSLIKDTASVCHMILSPDDLKACATALVENHALRHIDLSHNNFRCKGGILIADGLAKNRFLKSLNLSWNHLRMDGAKALAESLLENSDLEELNIAWNGFHLRGCLALGHALKHNSSLVSLDLTCNRVSELCLAQLLKGIQENSTLQVLKLPLNPMSPKSAYSVLKFIEDHQQIALKYVDLGDQCVHEEFKTLLLELQAVKDLTVIYGPILRPGLSLDAAAAEKAEAELDAMMGENPLIVLMEFCRLQNLRLVDMFNTIDTDNSRSLSYDEFIDGLKRVNIPLSEDSLKMLLKFLDTDGDGHVDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAJ5</accession>
    <name>A0ABM0KAJ5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101846479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112903.2">
        <property type="nucleotide sequence ID" value="XM_005112846.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101846479"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033776">
        <property type="entry name" value="COMMD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037351">
        <property type="entry name" value="Murr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21199">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21199:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17221">
        <property type="entry name" value="COMMD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="119"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005112903.2"/>
        </source>
    </evidence>
    <sequence length="192" mass="22031" checksum="53FB3EC5D0434195" modified="2025-10-08" version="1">MIIKMADDAKCFQALLNGLAKRNYYGVKELTDDVLKEEIYPELGQEEFNRLNSKCTGLLKNLVSADMDMTQLEAFLTAQMKRKEGGMSEEQAAVMRKFWKGNKAKIHDSIVSQTMWGNSLQKVSWRVDLKSQSMTEEQINTPTAIMELQVADNLNKQRNAEVIRFELDEDKVAEMLSNMREIDAQIHKYTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0KAZ6</accession>
    <name>A0ABM0KAZ6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852594</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005113250.1">
        <property type="nucleotide sequence ID" value="XM_005113193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852594"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033547">
        <property type="entry name" value="transpos_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="163"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005113250.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37546" checksum="98E7117D9B5FC8C1" modified="2025-10-08" version="1">MSEEASGPSSAKKACKDFSDFINFSQLCRYTSTFEECVQFGQKWGLFPRSCLCPSCGDILDTVHYSKRGNATQARFRCTKRACRKYISITKKTWFEGAKVSFKKSLFLAYCFVNRSSYDTAIRETSGPDFDDCETSSETVADLYNYCREVIVESLYCGDEVRQIGGANYSVEVDEAKFGKRKYNRGRVVDGQWVFGGICRETKECFLVPVQDRTQDTLVSLIKKHVAPGTIIYSDCFKSYECLEREGFRHLTVNHTENFVDPHTGAHTNTIESTWWAVKKSLRSSHTQKQHFAAHLAEYIWHRQNADAKCKFVRFLKEISKVYPGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZVF5</accession>
    <name>A0ABM0ZVF5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein LOC101857628</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101857628</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012935302.1">
        <property type="nucleotide sequence ID" value="XM_013079848.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012935303.1">
        <property type="nucleotide sequence ID" value="XM_013079849.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857628"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045021881" evidence="4">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="5">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012935302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012935303.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="21635" checksum="67CE796B72329B41" modified="2025-10-08" version="1">MRVSAAFLLVFLSALPGFRPGDVTVQAFGPATAGHRYPQHPAGGDDDPLDVASDLDPRFLYTDDLNDPLADLRDVYGQPDYPMGVPEVGAHGDILNGFSLVSGFDVGLNGYHGNVMAAVSCPEKCLCTGTSVDCSGQNLTAVPKGISPLTTGLDLSMNNLQKLPEDTFKEMTSLRELRCVGNNLTRLPKKLFKYNTFLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZWY0</accession>
    <name>A0ABM0ZWY0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sperm surface protein Sp17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106011372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936202.1">
        <property type="nucleotide sequence ID" value="XM_013080748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106011372"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12100">
        <property type="entry name" value="DD_CABYR_SP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047579">
        <property type="entry name" value="DD_CABYR_SP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699:SF11">
        <property type="entry name" value="IGLOO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699">
        <property type="entry name" value="NEUROMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="2">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012936202.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32907" checksum="E7C0D08821024517" modified="2025-10-08" version="1">MAVPFSNTKLRVPNGFQNILECLAREVLRSQPDNIHEFAAAYFENMMKVRAETGHDPAVHGAKLDDRNYNNEAFKKRSVDPSDPEQNSAALKIQTQFRQHSAKEEVAQMKEEVAATRIQAGIRGYLDREEVRKLKDGEEGETEEVDIDLNDPEVEQAAIKIQAGFKGFKARKEIQGSGEETQPQEAEQTTAPPPDADEEEVDIDLDDPDVGKAALKIQAGFRGLQARRDVASKKPPVDTNASLPDQGHDLDIDINDPDLRAAALKLQAGFRGLNARKEIQRRKVAGCFLTSLVSVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZX33</accession>
    <name>A0ABM0ZX33_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTPase IMAP family member 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC106010960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936299.1">
        <property type="nucleotide sequence ID" value="XM_013080845.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106010960"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF184">
        <property type="entry name" value="GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012936299.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25973" checksum="4DA1A28B0C786B8E" modified="2025-10-08" version="1">MGRHLNIMLIGKTGNGKSATGNTIIGRDVFDDSDSATSATNRVISASAQVGNLTVTVVDTPGMRDTRFYDPSTETAKSIDYTNDALDDCSGEIHAFLLVLKYGSRFSDEEVGVVRDWTRSGHGKDVLDRCIVVFTHGDDFRHRYGNNEARFEQWTCEQDGALGQLLRSVDYRCVLFDNVRADSQTQNRQINITLNMANKNNQNKGSFTKQLLVHIVKTVVKTALAAAVSFLCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXE9</accession>
    <name>A0ABM0ZXE9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Histone-lysine N-methyltransferase 2D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101848281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the even-skipped homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012936483.1">
        <property type="nucleotide sequence ID" value="XM_013081029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848281"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052002">
        <property type="entry name" value="Even-skipped_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294:SF4">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="702"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="704"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="809"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="506"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012936483.1"/>
        </source>
    </evidence>
    <sequence length="852" mass="93694" checksum="4F65896589EFF49D" modified="2025-10-08" version="1">MQPSSPKSPGIVKMDDEGVDNGDDKEQDINIDDISDDEGEARTTSNDVAHNGRHSPQRLGVKESAYLRTGSDDSVMDSQSDRRQGHEKLPVSSRTSALSESPPPSPGGRGSADVMMDSLHKDASYLDDLKQYQLHVLERQRKFGDLGAIGLRLMGGEARDSIGDRGPMSLLASQHQQHHHFQRQQQQQQQQQQQQQQQQQQQQHMMDLLYRNHYQQLYLMSRNPARPSSLSPPSSTFSATPTPQAPPPLFVSQNHLSPLQPVISSRSLLRDVGETGTHAFRDFHPSPKHIRLGSENQNRIQSPTNPDRALGYRGSPHKDDSNPSRSPHGQNNNPEDHERGLMNASASEKWDSNSGQCSPGGRRATAPDTAATFVTRNSLPQSSSPLPSPPPAHPHGALRDEERNATTTSSTTTTATAITTTAATRATRATPPPSPPPTNPTSSGISSNRKRSAPDDVTDATPPSSPNLTAAVVSPRTSKLPWRPIDCGPPSPPPPPPPSQPPQPQTQPLSASTSASPPLSSSSHLLQPPPSSSLSSSPPHPLQLPQPQSLPSLLSSSLSSSSSPPPPHPLQPQPQPYSEEYGDIDQRNHRQHHNHNLQQHHLHHHHHERGTGQGEQSLHHREEADLSGRGLEEEMRSRSPLLSPDVDRSSARSNTPSPARSRNASVTDNEKEEDLRLRSPASESPPVSPGNEHSDTSGDYNSQVRRYRTAFTKDQISRLEKEFAKENYISRPKRCELAASMNLPESTIKVWFQNRRMKDKRQRMALAWPYGIPPDPHLYAYLAAAAASYPYGFAASSQLAAQSASLSALAQQQQQQQPQRAQLAPQITPQMLQQQQQQQRIHISPQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXI5</accession>
    <name>A0ABM0ZXI5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 74B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936544.2">
        <property type="nucleotide sequence ID" value="XM_013081090.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011434"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936544.2"/>
        </source>
    </evidence>
    <sequence length="571" mass="62984" checksum="D01538CEB1A3EF43" modified="2025-10-08" version="1">MERCLSRKSEYDEEDIDPVSGLPFWKVPPDKEVVRRHRTWSSRGRRRVQQRGRVLSARVSQVALNSVADTGDNGGHRTESPDNAENSKKSGLAEETCGQQQSKTKILADESSSRSPDAKRKEETNLKDKIHDADNTKGARPEINDNRKRETDDTQHGQHRVTSGQNLGDLSPSDPNNVQSDSEPVRDSDSADKKQSHEGHWESRDRNSLRVLTPARPKTTPEGFRPRMKDRPVAGRPSSDGKHLGVEGSRQTTGGDPEDVSLPGDVASEKDENEEEEDSSDEYDTDCEPELDSAFRQSEHRQSSLRQEVDIGHLTYERECGKLKVKVRRRVLTQLWGDKMELRHCGLLAQEVKAIALALLRNSRVTRVDVSHNSLSGQALCYVFDAVRNKPNVTSLDVSGSNMDDTGASSCSAALSHNHWLLELNLSECCIGDDEATLLASGIQENRTLDRLDLSKNQIGMGGGLALGRALSDNSSLTYVNMSWNQIRGGGAVAVCNSLQKNKKIEEMDLSWNGLGFEGSLALGEVLKVNKSLLRLDVTNNRINWDGAPYLAGALFLNKTLEVLQVGGGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXI6</accession>
    <name>A0ABM0ZXI6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101858175</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101858175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936545.1">
        <property type="nucleotide sequence ID" value="XM_013081091.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858175"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35836">
        <property type="entry name" value="VCBS REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35836:SF1">
        <property type="entry name" value="VCBS REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047516246" evidence="1">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936545.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27562" checksum="A8338EEEC10F3AA4" modified="2025-10-08" version="1">MPSTFLNLILLAGLVVQSSCVAPTLLGKFSYPHAAFSTLYQQGTSSRYDLLLSSFGIFSSNVAVVSDVGQYLQRVSSINTKTLTQNVKWPNEVTGVPPAVLKSSTRYMAIPDGFLVPGKTYGSVSLINVDGSQSSPKTITGGGNWFYHRVRWVDMDKDGRLDGLTARAHKPFIGSAQGQLLWLSNPAGHSIDSPWTENVIASGPDTFFEFSTLTAGGKSYEVILTSEFFDQKLRIFWTEDPQQNWKNTQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0ZXU2</accession>
    <name>A0ABM0ZXU2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106011465</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106011465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012936717.1">
        <property type="nucleotide sequence ID" value="XM_013081263.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106011465"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012936717.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="37057" checksum="A6303572F990772E" modified="2025-10-08" version="1">MSYHRYSTAQRVGVAGVLVGFMLCVVAVCTPYWKRGELDLASATGLSILRRFPIFSGVRVVSLRAGVFYYCLQEGSAKDECKKPPIELAKERDKALLGMLTIQLLLAGFSLMAAVWGQYSKVKDTRVTGVIAFVSACAGFTAIALFVTITEDSWKLRTLGASLDWGFYVYIAGIGVMMAASVLLCCSVPVRPLGGLVRINTVNNQMMNRGGPYISSLTDITAPYNVGPISSSSGIIAPYRGGPLSSPSSVLAPYKGGPLCSPSGILAPYKGGPISSPGGIPPSYKRGPISSSSDIPTPYDGGGLILAPNKRGLVSSPTKSSDKFIFPNTETCLMTTPTVGKRPKPQTGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2Q0</accession>
    <name>A0ABM1A2Q0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939641.1">
        <property type="nucleotide sequence ID" value="XM_013084187.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012155"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012939641.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24134" checksum="0E5B43C0F6CF7A16" modified="2025-10-08" version="1">MTDNITGRRFLVDTGAQVSVIPATQLDKHTGTCGPPLLAANGSNIATYGMRIIPIRTKDRVFTARFVVADVKRPLLGADFLRRHNLLVNVRGLQVINADSLAIYPCSTHRVANASIQELVPVAPQSNKFRKVLSEFPQILQPTFSSSEVKHGVHHHVPTTGPPIHAKARRLAPDKLATAKEEFKKMEDMGARGHLFCTWSLKIVETGDHMGIFVASTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A2Z4</accession>
    <name>A0ABM1A2Z4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Lys-conopressin preprohormone isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC100533519</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the vasopressin/oxytocin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012939782.1">
        <property type="nucleotide sequence ID" value="XM_013084328.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012939784.1">
        <property type="nucleotide sequence ID" value="XM_013084330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100533519"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.9.10">
        <property type="entry name" value="Neurohypophysial hormone domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000981">
        <property type="entry name" value="Neurhyp_horm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036387">
        <property type="entry name" value="Neurhyp_horm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022423">
        <property type="entry name" value="Neurohypophysial_hormone_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681:SF5">
        <property type="entry name" value="ISOTOCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681">
        <property type="entry name" value="NEUROPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00184">
        <property type="entry name" value="Hormone_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001815">
        <property type="entry name" value="Nonapeptide_hormone_precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00831">
        <property type="entry name" value="NEUROPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00003">
        <property type="entry name" value="NH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49606">
        <property type="entry name" value="Neurophysin II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00264">
        <property type="entry name" value="NEUROHYPOPHYS_HORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012939782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012939784.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="17977" checksum="EA4E052EA5796D10" modified="2025-10-08" version="1">MSHSSMSPLSVRTFVLVAGLAVISFSVVADACFIRNCPKGGKRSMDMQLLGQRQCMACGPDGIGQCVGPNICCSPHFGCHIGTPETEICQKENQSTSPCSVRGETCGYRDSGNCVANGICCDSESCAANDRCRLRKETSRIGFDDTQSSRAEVLKLIQKLLRAKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A315</accession>
    <name>A0ABM1A315_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC101851652</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101851652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012939825.2">
        <property type="nucleotide sequence ID" value="XM_013084371.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101851652"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="154"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="NWD1/2-like winged helix-turn-helix" evidence="5">
        <location>
            <begin position="390"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1368"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012939825.2"/>
        </source>
    </evidence>
    <sequence length="1450" mass="161575" checksum="2D3E6BFD1D07D2EE" modified="2025-10-08" version="1">MNIGTSSQLQLGADSHDDMLSHLHMKFAQKLLSRQSSNFSKRTVTNTDVEACLTNLKTEVSSCLPKENRKSYSVTWQAGGVQPSSNPEHGQYITELCQDFVERVKLLIQADQLAKETLIRQRNYASQYGEVLHHAHFCLTKCQSFCGQEQTLEQIKAYVLDPSNRKPLVLHAQSGAGKTSVMAKAMSSLRSWVKEDHVGVIRFLGTSMYSTDIYCVLRSVCGQLADNAQVIMEPQGYKTMKALVQYTARFFRAMSNTLKQPIIIFLDSLDQLESSYDAYSCWWLAVNLPANFKLILSTLPTEHGILGNLRKVVGEDKNFLEVQVLPPDTSQEIVDKYLTLKQRCVTTEQMKFILDTFQKSPQPLYLKLLMDEALGWSSQRAVSSLTLPGSVREAITQLFQQLEVKFGPVFVRSALGVLTAGLNGLSEIELEDAVSCVDAAMVEAYKYHDPPVPGMVRVPTVMWARLRYDIQEYLVERQSQGQITLCWYHRQFIEVARERYTQGEQGQELHRVLFEYFASESGVKKDITLTQRRNLHIPAADRNTTPQVMTSANLRQLECLPYHLRKSLSVIDLEFAKKKTYCNLTYIRCKVAAVGVDSFIHEMEKFLSAHKDCEVEQVVNFVQRCKTSLRDAAVCAFSVLAHITTTPSQTALRYLKDCARSYLTSQRRTALIPSLACLAPRHGEADKSLVGLSSVMLRGNDVMVLTDSGTGGEALGDGEEKVTVLSRVDLSTFEVIKYMCAGVTGRPVLTADGKDLIYLSSENWTLVIERSNGEQKCTAVAEIVSKSECQALRTSSSDCQLATSDDGKLLAMSIGGKIFLLTYPELKPVADFHMEAQSHVTNLHCIGGRSLGMVASGCLSIEAEPAVQGVVTVWGESQKPAIEVSHTTFRIEPGASSITAGQDYHVCYGEEESGKSMIEVRRIRPTEVTGRISVTGDVRCMNLSPTDTQVWFQVGDCNLQLLNVETRSFDKTLEHPKNVRAWEVSWEMDRVLIADVDNCISIYQAGNLKLVQSRVLAGASITALGFYQDQIALLNEEEKLSFWNQKEFFLGDLVSKVSETAGVDNSKVLEYQRDIICLTVSADGRELITVGRDRRCKCWSLADNMLVREFDLDIVGSELYVLPEDKLMVRDGDNMQLRVYCLTSGLIYCDSLPAQIACLSLMTNRTKALLVAMETKPVLYMYDIKSNSSSKIFSVNANFRFVSCQVMVSRSERYAVLKAEVTQREYDSIAALWTKGKVLPKQKHPFRFVAVDLSQKSGAPLYAFHRLSKVPHLGVAVEPYLGNIFMVSTRRWVMFWDVPTGSCDQTMCKATRKTKMYRPDWVGRGCVGANTVLQMSFDLKYIAVGSQDGYLMVYVAETGMPVGMKAPTSKHPSPVIQACFSPSGELVASACTSGLVNLWQVHSATSLFSVSVGSEIQNLTFTSSGDKLVAVTVSEVSRVLVFEVQEVISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3D5</accession>
    <name>A0ABM1A3D5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101864695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101864695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940005.1">
        <property type="nucleotide sequence ID" value="XM_013084551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864695"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940005.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="58745" checksum="1AE4AF66DAFCD075" modified="2025-10-08" version="1">MSNQVHNASCVFRGWYQVTRASRQEKQTVLQFQVQSYTLLVQRLFHQWLACYQRRRQVQQERVWRAERSALELAAVWRRKAQTSRGARVKVMFQHRKMALYFNNWQKSLDSVQSLYDTLEVWNRQRNARVMTRSLKVWRTQLVADQAKRDYTQRYLYTVWSEWRVCAKVNKERRIRGLALKKALQERSLHVYFQYWSALTLVKRSVQHNVETRIQIRVLREWHMYTRNTRYLRQLQAHMTKKVNTRVLHSAFSNMRWKAEYCVGLAEMADKMAGDRRRATMQAVMVVWRDRLDNIMAARCYGQLLVVRVARQWRRFVQAKKRQRQKEQEQWDAAVSCHSKTLRMKVMAALKTEVCVARMAQKRRQRLCDKYAVVWKTRVDREITAQCLEREFLYRQAWSRWRVEFSRRKAADKICGQDDRHSMSQTFKAWRRLTRPQQRTPRGLTEHRGSLSSLLPVPISQSRHSPSSASSSSSGSYSAAEQSFGYRGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3Q8</accession>
    <name>A0ABM1A3Q8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein 10 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101862122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012940214.1">
        <property type="nucleotide sequence ID" value="XM_013084760.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862122"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF43">
        <property type="entry name" value="GTP-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Obg" evidence="8">
        <location>
            <begin position="43"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="179"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012940214.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="44641" checksum="CC921CCF640C9E90" modified="2025-10-08" version="1">MALPMRCGTQSKVLSIKSYKLLNNLLLLTVRKYAVGPKKKPIPKFVDFLQLQVTGGTGGQGLPKYGGFGGNGGKIFVTAKAKVKNLRQLAVQHPKQTCKAGVGDNSSKFHLLGNSGKDLNLEVPVGVLLHTEKGDRVDLNKEGDSCIVANGGIGGNRETNFLGLRGQTNMIGLELKLLADVGLVGFPNAGKSTFLRAVSKAKPKVAAYPFTTLTPQLGIMEFDDGRRISVADLPGLIEGAHQNYGKGIKFLRHAERTKLLLFVLDLNPFQLSEKYPERSAFETLLLLNQELEAYGHGMLDKPAILAINKTDTDPSGEKVTRLMSLVQNLPESLETVDEELRPTTLAKFDDILTMSAQNRDNIEAVRGKIREVMDEYAEKRLLEELEKKKSLMSLREDEEHLKTTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A3V4</accession>
    <name>A0ABM1A3V4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101855118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940293.1">
        <property type="nucleotide sequence ID" value="XM_013084839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101855118"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4-LIKE WD40 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940293.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="37908" checksum="4A6E185D23F0A51E" modified="2025-10-08" version="1">MARRILEQEMLAAEGITLDPLGPAQSLEVVKEIKLHKTFNGVFSVQFNHTGSLLAVGFGSGGVQLFDPLTGTMTKELRACRQGGSSVMTLRFHPKEPDVLYAGTTEGYVYIYNVKTGEQLGTIEELGNEINTLDFCVDGFNFATGGKDLNVRVYETKHNKLLRTYEGYNEKTFVTEKNKVANTMRVFSIKFHPNNQYIFVSGGWDNHIKIWDTRDNEGIKRNIRGPHICGDSIDMKDNNILTGQWTALHALQLYDYTSGKVVKEINYPHKDGAFLYAASYVNDNTVMGGGSGTNSLEVVEIDTNRHVGGYKLAGPVQAADSANNGRIIAVGGAAPLFTILKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A478</accession>
    <name>A0ABM1A478_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized transmembrane protein DDB_G0293028</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940509.1">
        <property type="nucleotide sequence ID" value="XM_013085055.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106012341"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940509.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16298" checksum="1FC4805BF6CFC804" modified="2025-10-08" version="1">MCDINSCGTSAYGYDHHQEKVKEMAEMEEAEKEEAEEAEKEEADEAEAEKEEAEKEEAEKEEVNGKEEVNGKEEAEKEEAEKEEAEKEEVNGKETFWKNNKFGALQGREQESVFIKAAHLVSRRDIELRGYSTLLFLFAFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4C4</accession>
    <name>A0ABM1A4C4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101848216</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101848216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012940592.2">
        <property type="nucleotide sequence ID" value="XM_013085138.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101848216"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOMON" evidence="1">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012940592.2"/>
        </source>
    </evidence>
    <sequence length="88" mass="9751" checksum="29FDAFA03E69591A" modified="2025-10-08" version="1">MNLTDYFEDLKSVRISGPPPVPAGKFSQDPGCGVSKGCFSNCENQVCDWESSWEEQGSDYRIVLRSTFSADNKYLSLGFNSLLGKMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A4R4</accession>
    <name>A0ABM1A4R4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multidrug resistance-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC106012418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012940811.1">
        <property type="nucleotide sequence ID" value="XM_013085357.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012418"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="164"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012940811.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45054" checksum="F5C6F9025B7C32B7" modified="2025-10-08" version="1">MVYIPTSVQLRRFASVNQSPVYSHFSETLTGASVIRAHGAQERFLRESEERIDEFTKGVYGIDCAAKWLMCRLDFLSHIIVLTTCVLAVTLRSDLSPGLTGLTITYMLRVTKNFSTVTRLSGEYETAVVSVERIMEYSGLESEAPWTMPTDSDEKNRWSEDGSVQFVNYSTRYREDLDCVLKNITCKIHGGEKVGIVGRTGAGKSSLSLALFRLLEAAAGTILIDGQDISGIGLHRLRRHVTLLTQEPILFAGTLRRNLDPFRENDDSDVWSALDHAHLKSFIEGLPKLLDYDVGEGGANLSMGQRQLVCLARTLLRKTKLLILDEATASVDLATDELLQETIRTELRGCTVLTIAHRINTVMDYDRILVLHQGEIAEFAPPAELLKDSRSMFYCMAKEAGLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5I9</accession>
    <name>A0ABM1A5I9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101856446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012941234.1">
        <property type="nucleotide sequence ID" value="XM_013085780.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101856446"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012941234.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28276" checksum="BA8F9D5890D33523" modified="2025-10-08" version="1">MKLLENAKLEAINSALCMDLDNCNTYIEGRLESYSCKMAGNDKRLFKTMNEENREAPGGLQALSPSVAFGYASSTSPIGTEPYTHAVGSHEEGGILCDTISTKTLFYLISTLNASFNPDYDFSAAKSAEFSRETSLEWVVQNVNSALMAAAGDKYGAFKQQLWSSLDDEICLKDCYIYSYNPDMSSDPFSEEGCIWSFNYFFYNVKLKRIVFFSCRAKRKDTMEMDGDMDFSYDGNDDLMFAGSSQSGRKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A5K1</accession>
    <name>A0ABM1A5K1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic cation transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101847830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012941248.1">
        <property type="nucleotide sequence ID" value="XM_013085794.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101847830"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="109"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_012941248.1"/>
        </source>
    </evidence>
    <sequence length="564" mass="61605" checksum="5574CBA9D2A62547" modified="2025-10-08" version="1">MKYDDILQEIGDFGPYQKRVYYILCLPSAVKAVIIMSTVFLFSLPDYECVSSGIHLQLSDLNPSLQSLVNSTSDLMDTTYASSSSAHPDHCWVPTQIEIPLNVTISVNVSAERLLGSHVTALARTGVPEAVKCQEWRYDRSEIESSIMTEFNFVCDKSMMRSHANMGLFLASLVGALVIGILADIIGRKKALLFCVALQLGSCLGTFFAQTAVAVVVLRSVQGLSGEMFPIAASTGMELLGQGRRTFAGTVVQFFWSAGQLLVLLVAYVSGGWRVQELVYAACAVPLFLAVWLWTPESPRWLIDKDRQAEATDILEKIATSNKTKLPENALQNKDELYDTEESVLTIIRSRTLLIMSLVVLLNWFTVNVLYYGLSLNLENLSGSLYLNFLISLSVEVAGFAFCYVLLDRAGRKALMIGCMFVGSLACLCVTFPVVFGNADQQWIVTTLCMVGKMCVGSCYAILFIMSVELFPTVVRNSALGACMVFENVAGMVAPYITDLGLTTTHTEISQAVPLLVFGGLGVVTAIASLYLPETLGKPLPETFQDAIDLSSGGKNKKERQGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6E3</accession>
    <name>A0ABM1A6E3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">TBC1 domain family member 10A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7 8" type="primary">LOC101857130</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005105063.1">
        <property type="nucleotide sequence ID" value="XM_005105006.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105064.1">
        <property type="nucleotide sequence ID" value="XM_005105007.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941695.1">
        <property type="nucleotide sequence ID" value="XM_013086241.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941696.1">
        <property type="nucleotide sequence ID" value="XM_013086242.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827390.1">
        <property type="nucleotide sequence ID" value="XM_035971497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857130"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF4">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="105"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005105063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005105064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012941695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012941696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827390.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45548" checksum="2FA8E416A2F4709D" modified="2025-10-08" version="1">MSMAMADFSHIPEDFESPTEVNSNGGSPKAHTVANGDSVQSNITPASTDRYGFLGGNQYTDPEAERRVPQETVRKRETKWLDMFINWDKWMSKKFKKVKDRCRKGIPPSLRARAWQHLCGSHFTLEQHRGVFEEYLKMPGDPKCIDDIHKDLDRQFPLHEMFLSKGGVGQEALFEVLKAYTIHRPVEGYCQAQAPIASLLLMHMPAEQAFWCLVAICDKYLTGYYSPGLEAIQLDGDVLFGLLKRTSPVVYKHMKKQHIEPIMFMTEWFMCVYTRSLPWTTVLRIWDQFLCEGVKVMFRVGLVLVKVTLEGQENMSQCPTFFDTLEKLRLRKLAPELQDEEFLIRETLRLNINERDMEKEHQKQIVRRKQARESKERESGGGAGGKHARKAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6K3</accession>
    <name>A0ABM1A6K3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC106012678</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC106012678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941801.1">
        <property type="nucleotide sequence ID" value="XM_013086347.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012678"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941801.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="22937" checksum="C7E52D69814D8F33" modified="2025-10-08" version="1">MACLDTTDQKPECVATKSLIASKRLTYDAVITAACTSVPSGDTCVSDVENCEQTFLQGVSLAGTDVVAACGAGQTFEDCLKQRDADTNCASHRSVIDNMRKLYTQEISQKGCSSPTVVACVQGMENCSSVYNVKEAKMTSSKECSDATAFVGCLYKLTCTAAYRNQMNQLFNIIRAMIKATKSDCNPFGGVSAVTSSVACLVCGVFLSVFSVFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A6W8</accession>
    <name>A0ABM1A6W8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC106012738</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC106012738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942006.1">
        <property type="nucleotide sequence ID" value="XM_013086552.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106012738"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942006.1"/>
        </source>
    </evidence>
    <sequence length="1127" mass="123940" checksum="9BA3723E23AD9537" modified="2025-10-08" version="1">MAVTSAANWILRSLMTCILSGAGFVFITLVLQYAKRYSRSRQEKEKARVIAEQFLKDALLQECYGSRGVIIPKVPDIGCGSTSCLAQLRCSLFQMYKRSGCFLGFGRRRQEENSTANHLDSSLSDEQVDRILQLVRFDRYGSESKLREECGGFDTPSKELVLRSSFVSEGSGRKRWSPERSWYRSKRQPDSLGRASVHCNRIPCIQEPLGDLKLWSQFPPKAVDADSRLKSLKKRGGFYDDLHSRVKKEYSFILPYLRGNHQKQFLSKKSIKIQPLELFESPSDYATWIKENKNRIEERVESSPPPEQAVAFQLVGRKSPGRDKQLGQLISPDLRTTPGSKETDGRRSAPASPVGLGAPAKETVPTVDRRLSRTRAQRIRSKSVARSTNSILKNRTGSDSPKKGRLLKSNSSASLGKSVKTKKVENIKLNDITSLPLLAKFDTRAVHGKEREVRGQNRTAKKPPTPLNKPPAVLMKRTRTDTSLGDKIAQNRADDGKHSSNGLVPYGSTADDKPQGDIVRKTTRQSPVHSEQSFKGLSVKARGRSLSPRKTRSPYMSRNRSFYVKHSRDRSTLASPLNLGTGTKPPLARDTSSPLVLNKPKIGPKEPNSSNVPVDTTNTQGAHARSASKESARSFSRSRSKDRKLKPRRYLKTPLPPKQSRAVADAKGANPAGSKATGQGSANITSRPSSRQSVFTQRGKVKTLPLKQPQAKSPMPIQKRETNSPRGRKVQKQTISKPVEKKSKKERGNIAQGRKALLSSADGLKRKVAVRNPGQDNPPTVVSKIGHKPDSGARHSQGHTKHSGTLSTKMCAASLKLIANEHKNSSERKVPNIAAINKSPTVKTEVHENTLERVNPGTTGKTASPKEQMEIHGDSLECANKNMKINSASPKEKGVTSKIIKINRASPKEEDVTSKIKKVNSESPKEKEVTSRHSPKSINLTAVHPSFKSPPSPVWNKEPTQKCHMKEPTQPKGTPCSVGGLKFVLRKSTLDDVVVSLKNGTSCSKTTEVETSPFLRPNTATEPSTSPTDKPALPTPLKVIKIPYQDEQYSTAENKAVAPSLTRVENADPKKGDASLIMSTDARPCTTFGSGATFEIQSFQNVGNDASKALGEHGVKFQGLNFSTHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A751</accession>
    <name>A0ABM1A751_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942157.1">
        <property type="nucleotide sequence ID" value="XM_013086703.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860917"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045195531" evidence="2">
        <location>
            <begin position="25"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="45"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="143"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="486"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_012942157.1"/>
        </source>
    </evidence>
    <sequence length="608" mass="69059" checksum="43DBF706AA089850" modified="2025-10-08" version="1">MASRAMLLPLVFLAVLSTVKLTAAVRDFPELSHLKTKTSPDVQREAARGVISRLVKDRAADFDVDVNPDLGPKERDTFRLSSTKDGKILIEGTTGVAVSMGLYYYIKYWCNAQRTWAGQQTELPPTLPVIEKPVVITSNDRFRYYKNVCTESYSFAFWQWDRWEQEIDWMALHGINMPLAFAGQEAIFQRVYFQLGFNQTDLDEHFGGPAFLAWARMGNMRGWGGPLPQAWITSQLILQHQIMRRMFDLGMTPVLGGFAGHVPAAITRLYPHANVTRLGLWAGFNSTYSGTYLLDFEDPLFKKIGGLFIKETINEFGTAHLYNADTFNEMTPASNSSEYLSRAGRAVFQGMLAGDEKAVWVMQGWLFLDSSGFWGPEQAKALVTSVPQGRMIILDLATDLIPAYPNFDSFYGQPFIWCMIHNFGGTSELYGTVDVYNTQPFKGRTFPNSSMIGIGITPEGINQNEVVYEFMMENTWRTEPRDISKWTEQYVLQRYGANNAAAMSAWSRLMSTIYNCTDGHHDGDLVLFTRRPTINAGYDIWYRPLDMFLAWQSFLTASQELEGNQLFRYDITDVTRNSLQVITYFYYYSMMESYKVNDTAGVTSAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A753</accession>
    <name>A0ABM1A753_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CCN family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101859727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942159.1">
        <property type="nucleotide sequence ID" value="XM_013086705.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859727"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050941">
        <property type="entry name" value="CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017891">
        <property type="entry name" value="Insulin_GF-bd_Cys-rich_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043973">
        <property type="entry name" value="TSP1_CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348:SF17">
        <property type="entry name" value="CCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348">
        <property type="entry name" value="CONNECTIVE TISSUE GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19035">
        <property type="entry name" value="TSP1_CCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00222">
        <property type="entry name" value="IGFBP_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="IGFBP N-terminal" evidence="10">
        <location>
            <begin position="86"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="160"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="8">
        <location>
            <begin position="331"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012942159.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="53225" checksum="177AABEB92A59B77" modified="2025-10-08" version="1">MSPMTSQLQGGQRSGLGYSVISRLTLRHSTLTTMEVQQLLSSGLLFVTLTFLFLSGSAQADLHSPCLGCRLFNLQHRLHPEVNKTDTVFCHYPCQCPYEELSCHEGVTVVKDGCGCCYMCARQQGDICSVRDLCDVSKGLYCDRKDDKSVGHCQVKERRRSCNVGGVSYQDGEKFQPDCTQLCTCQNGFYGCVSTCPQEQHKPSELTCHEPKLIKVKNKCCREWTCQKMEADVNSRIASVEGLESQNLVLLNPLWYQSTTTSPAPEPTTPPLPEPCHTQSTDWSPCSVSCDVGVAVRIVVDSVTCMHVQERKLCYLRPCGLNLTTHGRDKCTPTTRTKSREHIQHQDCLSVREYKLKFCTTCREDACCYPKKTRTSTMEFQCSGGVRKTFNYMWIKKCRCDQVCYKKGPNKKRRMRRRRFRNREKRRRLRGKDKKKRNKSFSRRRAMRRRARRRMRKMQREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A770</accession>
    <name>A0ABM1A770_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding protein RFX6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012942177.1">
        <property type="nucleotide sequence ID" value="XM_013086723.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101853024"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF28">
        <property type="entry name" value="DNA-BINDING PROTEIN RFX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="99"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="583"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012942177.1"/>
        </source>
    </evidence>
    <sequence length="929" mass="100721" checksum="36774FD03BB8FB61" modified="2025-10-08" version="1">MSPAMATAGVKRARLDGLRHDLTTGLADRGLRMDSDGKSNKTSSDDEDDDVADDEGIMLEHGDNKGQQQQQQQQQPQQQNIKKTVAQIMRDKKKQTQLTLQWLEENYCICDGVCLPRCILYSHYLDFCRREHLEPACAATFGKTIRQKFPHLTTRRLGTRGHSKYHYYGIGIRETSQYYHSVYSGKGLTRYSLHYTGAQNQTCRPKFARSTKPPEAPPKKSRFVSNAKTPLGGFTRKYSLNSKTGTLLPDFPNARFLILPLSVPRDKVETLIMMYKTHCQCVLDTAINGNFEEVLIDVLIPSTMQEMPETEFKDLLRKQATVEAFTEWLDMVVEQKVIKPSKQNGKSFKKRAQDYLLKWSFFGARVMHNLTLNNAQSFDDTGAKPNLQQPAGTCFVASQSRVPAQNETLKREVYGDSTSASPYAHAQGHSRDVFALSPHLSSLTSITQAMGTAGNPMLTPPVSPIVPNPINPRASVISQGPIAAFSSTSQSLPLGSSFPYLGQQGSDYNLPHSSPGTGYVGNFSSNLYSSAFRSHNHSNSNINTTISNNSNNNGNSNINNANNTTANIASSSNHDPSHSAVVNSSSPIRSSVNNNSNINNNNSNNNNNNTSSNSINSNSNSSAVGNHAMNNSTNVYAPYPYHPGNFLSHHHHHHHHHPGTFTGSLYHQTPYGAKADAESTTSFPHYSDNPQFPSDVTAYFGPFCPAPSMQHGYGLGAANSSMGGLGGSVPGSSIGSGSTGSGSAFNVVHNQHSAAASFVQSHSIYQGTDYFSPPTFPPAPKPLVEHVPVIQQRLPVGASHYHNEASDPLNLLDKSYRAKDTLSMYGAAVTSKDVPGLYGAVASKDVGGLYGAMTNGGSGSCHSPRAMGHHGMVSHMHHPHGPAMSQLTGEDYLTSMGLGMSTVLSADPDMMASFTDTGPLPSINSVFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7D9</accession>
    <name>A0ABM1A7D9_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101860764</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_012942280.1">
        <property type="nucleotide sequence ID" value="XM_013086826.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860764"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057304">
        <property type="entry name" value="PDE8-like_REC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23198">
        <property type="entry name" value="PDE8A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="172"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="409"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012942280.1"/>
        </source>
    </evidence>
    <sequence length="766" mass="87092" checksum="800F5D31FA9F345F" modified="2025-10-08" version="1">MKNLEHDIKFGPMLLHQKAMSVLLVFGREDRQSDGFWWAAEKLGYRCNITSSPETALETYLTHNHDTVIIDARQTTTNTNSSNSSSSSKTTTSTFDAEALCRSIKATKCSENTVLVAVTSRTSADQEEQPIFSLIKAGFTRRYEENASVTACMNELQTLEVGEVRCRLQLKACAALFQALENVSEAVEVTNTDHEIQFVNHAYERVSGYSSEELLGRDSNHLNKSDKNRDTAESIHGHMKKGKHWEGTYYTRRKSGDTIPFHCKVIPVLGPTGSISQYVSVRSQFSDTYSQVANGSMMSFPRRRESVVRAHSMTIEAPITKVINIINAAQENSPLTVAQALDKVLEILQTSELYSPFQTQDIRPDDDPVASDLVDGLMSQNVKRKLSGHDIQRSSHHGHSHIPSSPAYTLSQVPEPVMNVLNLDSSWDFDIIALERLTNKRPLVHLGLKIFSRFGVCEYLNISETCLVNWLQTIEANYHAKNYYHNSTHAADVLHATAYFLDKERSREIFDQQDQVASLIAAAVHDVDHPARTNAFLINEKHQLAILYNDQAVLENHHASLCFRLTHKDQSVDIFKNLNSDDYKTMRQSIIDQVLATDMKQHFEHLSKFTTSITKHLQKLEGDNTDVEAHEADMNTILTDLSSHENRTLIKRMMIKCADVSNPLRPLSQCKEWAYRIAEEYCQQTDEEKSRGLPVVMAQFDRKVLNIPKCQLAFINLFITNMFDAWDIYCDIPELMNHLQLNYDYWKDQQELKEKEQKSSQGVDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A7G8</accession>
    <name>A0ABM1A7G8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012942326.1">
        <property type="nucleotide sequence ID" value="XM_013086872.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101857433"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012942326.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="49445" checksum="EBEEBEC4F1A11976" modified="2025-10-08" version="1">MDETYDVIVMGTGLKECILSGMLSVSGKKVLHLDKNTYYGGESASLTPLDQVYQHFGKPEVGDKFGRGRDWNVDLIPKFLMANGQLVKLLIHTGVTRYLEFKSVDGSYVYKGGKIYKVPADEREALASSLMGIFEKRRFKNFLQYVQDYDENDPKTFKGVDPSMSAKALYEKFGLDANTQDFTGHALALYRNDQYMALTSLDLIKRCRLYSDSLSRYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLDKPVDKIVMEDGHVVGVSDGKDTAKCSVIVCDPTYAQDRCKKVGQVVRAICILNHPIENTKDAQSVQIIIPQNQVGRKDDIYVCMVSATHNVCAKNYYLAIVATTVETDNPEAELKPGLDLLKGVEEKFVSIVDLYEPLDDGQDSKIFISKSYDATTHFETTCDDVLDLFKRITGEDFDFSKVKHTDVEAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A8P4</accession>
    <name>A0ABM1A8P4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-1,4-mannosyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">GDP-mannose-dolichol diphosphochitobiose mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101861537</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13865"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="EC" id="2.4.1.142"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012942962.1">
        <property type="nucleotide sequence ID" value="XM_013087508.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861537"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03816">
        <property type="entry name" value="GT33_ALG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="267"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="460"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_012942962.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="57525" checksum="27C5D62E612AF507" modified="2025-10-08" version="1">MSFALPILFYTPFVFIFLYLLVNFIVKTPRHVCIVVLGDIGRSPRMLYHALSFAQEGFKVYLVGYKGSVPPKKLVENENIELHYVTEAPNFFKYYPKIFQYFLKVIWQSLALSWTLLLLPKMGSYFLQNPPSIPTMAVAYVVSRVRCSELVIDWHNYGHTILAMALKSGHPMVRFAEQYEKICGRLSAYNICVTKAMKKDLQQNWNIKATTVYDRPPENFCSVSPEEQHELFVRLAREYPVFADRSGNEESTVFTQRSSSGEIVSLDKRPALLVSSTSWTEDEDFGILLEALKDYDLREAVPNLICVITGKGPQKEFYSKQIKERQWEKVQFCLPWLAAEDYPLLLGSADIGVCLHMSSSGLDLPMKVVDMFGCGLPVCAVKFECIDELVKHDVNGLIFRDSSELLTQLQDLLGGFPSNQGKLSTFRKNLELFQSVRWHDQWKQLVLPIFEEIGATQKPSQFRVQTGSGIPENFDDIGSEDGENSGNVHPSSAGESGTGAAQEGKKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9M2</accession>
    <name>A0ABM1A9M2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apolipoprotein D isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101862681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012943461.1">
        <property type="nucleotide sequence ID" value="XM_013088007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862681"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="2">
        <location>
            <begin position="51"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012943461.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23628" checksum="1DA5E51E5ECC61A8" modified="2025-10-08" version="1">MCGKYIAHHLSSLSYTHPPTLTTTTFLSLLPLVLYFSLTPHPPPFPPLPLQYLGTWYEYERFDNWFEAGMDCVRAEYGLNPDQTISVLNAGTRTFKLFGRTIFSRPASINGDATTPDPASPAQLKVSFSQFDVIGGNEPNYYIVETDYDNYAVVFSCFNLPGLPVNIQFAWILTRDRGVAPANLNAIKSNLQAAGVRTKYFKSVNQADCPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1A9M7</accession>
    <name>A0ABM1A9M7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Atrial natriuretic peptide receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC106013118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012943471.2">
        <property type="nucleotide sequence ID" value="XM_013088017.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013118"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_012943471.2"/>
        </source>
    </evidence>
    <sequence length="239" mass="26371" checksum="AEC77DFBFB8A3B8D" modified="2025-10-08" version="1">MLLDEILPRSVSDKLKQGQPVAPESYEQVTIYFSDIVGFTSLSAMSSPLEVVELLNALYSNFDSTIDNFDVYKVETIGDAYMVVSGLPLRNGNDHVLHIARLSLLLLQKVAHFRVPHQPSHKLQLRIGLHSGPVVAGVVGVKMPRYCLFGDTVNTASRMESNGQANKIHISESTKTLLDQVGRFEASLRGEVEMKVEPVPCHLITCTRTGVGFKKIMMTINNIIDATTSSPYPLSLFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAJ3</accession>
    <name>A0ABM1AAJ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC106013283</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106013283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012944007.1">
        <property type="nucleotide sequence ID" value="XM_013088553.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013283"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1152"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1244"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="751"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012944007.1"/>
        </source>
    </evidence>
    <sequence length="1264" mass="142248" checksum="EA714FDD29E1D58F" modified="2025-10-08" version="1">MSSTRKETSVGESDANTLSQVESRESIESTSMDEVRKSSHAERSFGEEVRDSSTSEKSFSRPGEERISTERIPSGESRTSTEEERLAVTQTKLSMTNDGRRAVDGHRKRSSKRHKKMSTEERNEELDQENRRFSSRQGSTFLLNDGEEFVEENRQKPPEMDVTPTVTGEVREVKHTRKPRAEDRASMLRETDFQSKNQKSPGKDHADYTSDEKQRVFVDKSQRSLSEEVLESNKPEDWRTSTYVDQQLSRNELKLSHADDNRKSIQFKSVSFNLDDGDRVVPPAPPVSRRTSTDAVMSSPGIVLPQNSLADMDPISEEISFFRRPDRSMIINHDGRSRIESICGFRRQPETRVRTNCSSQTLEIQNAKILTWEEAQEIMAGQMQDLLKSPRTVILGEQGTMTCQTSLSATPVSILKKAPETRSFRCRSPSPLLQRPNKPRHSISPGRKPVLERRPLVNSGNIEVSNLPDNVPGIFSSDTSMSNANPGDPTKTKEPDYEGSNVEASEKSPLGNKINLQSEGVTEGEELQDPYWEYFGDGEGYPEGDGEGYPEGDGEGYPEGDEDYYYYYPQDDSEEWANHYLEDPTAQGGMDSGQEGVFDLPVQNEIESLNPGQMDVVQPDTTPPSPAKVLLDDPEDSGVVRSSLSDPPKQASPELGSIDGGWRRSLDQTTPSVREFDVDPKPVASTQDQNIPRISIDGSSLKIEPTTAVERRSAVPSQVSLSTTKQTSSRNLPRESSVKDANLPALLEVPQEDREKPRIVIDRSRTNMSSTTKMDSQPVLPTVQSRSVSRKVSGASLSPSVKSPHASPRPSIHIPKRPRPVRNVLSVATPQNIQEAVDKSAPLNDIRDLLVSIREYLTSNGDEKSKQSREMNETANTILKELKRSREKKTDDGNAGNDPKTSDLVISYEDTQTVEVKVVFLRVADIDTISQQFEADVHIQARWQEKQFKGMTEKELDVVEFSQCWDPQLKILNILGGLDSEKATMILRYEPDYAYPVLTYMWQVKGLFREHLELEHFPLDVQELSIVLSSGRSVKDIELVQDFFHVSSLSPRALQDSQDWLPYYHVTFLRDVTTSESIGTTKHPVLVASCRARRRLGFYLWNVVIIVFLILGLSLTILAIDPTGNDRLGVTMTLFLTAVAFKLVVKTTLPPVSYLTYLDLYVVFTLIYLALQAAENAIMTHLAKFRDRDSVLFYDEVAQSVLIGLLMLFHAAFIVYIQLTAMARRREMAQKDYEHKMAQLRIRKSLQQKKTPQVSEEPPALPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AAW3</accession>
    <name>A0ABM1AAW3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein TBATA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012944195.1">
        <property type="nucleotide sequence ID" value="XM_013088741.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101856489"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037394">
        <property type="entry name" value="TBATA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33772:SF1">
        <property type="entry name" value="PROTEIN TBATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33772">
        <property type="entry name" value="THYMUS, BRAIN AND TESTES-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15256">
        <property type="entry name" value="SPATIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012944195.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="50647" checksum="E4F9ACE186B8BA3A" modified="2025-10-08" version="1">MATASEVFRPSDGELLIRDSLSQGPSVPTDTFKKEDRRPMTQGGYRFGQLSHNSFFTRHNPHPARVRHLKGLLDVPICSVNDDGYFANPRYSLQFPPNQHNTNRLKNWKGRIPVNAINVNSQLHPINTITGLQYFMGLNSYPYREKAIPKVGLVPVTEAWRDELSAFTQKLNLDNEVPAPASASGPKPEEEQRPRSTMYSPETGRLIPPPSRAMSRGGSRRGRYNGQQFVGGSLQHIAADPDLENVVLVMLCQILQTEDVNAVQAWLCSAGEREKEHVMGLVRSAIAGREEYYKQYPAEFIPDNGKAKLPPISQKPGSASGETNRLVLDEGNNGAGEPDNNGRWQKMWVPPVVPIEENAAAEEGGEQQEKTVVDDSNVFTVTPPVNDVFKAMPPTTRKPMTPLQPARVPTFTRPEPPATPKPASPEATKLKYTKSPPAKEQPLENMWSQKQSLNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ACN8</accession>
    <name>A0ABM1ACN8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101858141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101858141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012945162.1">
        <property type="nucleotide sequence ID" value="XM_013089708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101858141"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058831">
        <property type="entry name" value="LolA-like_dom_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902:SF1">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25898">
        <property type="entry name" value="LolA_2nd_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046451436" evidence="2">
        <location>
            <begin position="27"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="873"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="743"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945162.1"/>
        </source>
    </evidence>
    <sequence length="912" mass="103116" checksum="9EAD4804777BE12A" modified="2025-10-08" version="1">MAGLPGFLGPVLTSALVVLLIHSSSCADAPYTCQEIAKPSDSYASPRGLSYFTAHVQATFMERQQTFYSHINVLGSSAKMSIRAANKTTEYILNRQEHEDSLLTLEVDFPNTKDEKKTCTVGDKDHQWEHISQFLVNSNTYYRKLVNQTTAAPIDGVPMNHWKQCFTFKGQTQFMFDYYFIAGRYNWKTSTKDMYREVPVRIEVMGNARGKNFQHFYEFFDVQFVTTGNFDPPEGFTCALPSAQVKKPPLLPPVMRYFVEEYQINTRRKYTFKTPYQMSFDKQKQIARYTTQYTDIVTDYKAGVSYTISLNTDNLCYKRAAVDSSRYGVTSEINQQTQKVEMRYPTDFDGLSKGDHFTYNGKRKCRGMSCDSWTADNIPWFGGASTAVGEFRFYNDLPISISYLVDNETQINYDFFGLHEFETDFDKPFDVSVCYDDEETSMFRISLDAPRSDFSSGGEEARNATILRELRTQIAKVGAISELRVKVSDFVVFGSKLQAILRLFPVEYKIGYKDQNDDHFVFDALVNAINKKQISIMITGIALHNMTTNTGYKYQAFTRRNQTITLTDIVGISGDLVYNPNDQKVALAKYDKMINQVYRNFIPVQRMSASNPESCARKCEHYEKGKCRVFQFCGEDRSCQISVKDADVDKSYQWINKVGCSTYVKGYIWDFIPNPGKVAPEKADFLYQGLVKEDNCAKMCLEEKATNCWSYDYCLGRQECFLSSRVEYDHPLNWKSLTEVPECIHFQRTYLFDYQAHYARNITDKEDMFLEDKSEEGCAAACSQGTRFLCRTYDYNMVTRACRLFQRPLTGHGALSTSNSGGDIIGERVLFGSGHINATFGTAGTGVGPSNGPTVTVGNPAASTGSGYTSGSMAALGIVMLIVGGVIGAAVLIVFARRRKSASSVDMNIPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADU8</accession>
    <name>A0ABM1ADU8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Selenoprotein N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101859989</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005112350.2">
        <property type="nucleotide sequence ID" value="XM_005112293.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012945797.1">
        <property type="nucleotide sequence ID" value="XM_013090343.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859989"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16213">
        <property type="entry name" value="SELENOPROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16213:SF78">
        <property type="entry name" value="SELENOPROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0711">Selenium</keyword>
    <keyword evidence="3 4" id="KW-0712">Selenocysteine</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="4">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005112350.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012945797.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="63577" checksum="B428E96B63661C13" modified="2025-10-08" version="1">MAKPGRKQSSTTEGKMSKKKLLNGELGSNGEPVQHEVTTRADSTNYATRGAITLVVPRWLYCYMPIAVGVLAVVSSSFVSRYHQHVLEDQLLKKTDTLGLEAVDVFVDLDKDGDFHLSLEEAEPLLLHFVDQAQGKPTVFSSDVIPGEDVVSVVARFTPLNTSTMTKDFENDFQNNESFHGLFHWLSPHTPVKDFGVSRFRDLLPDDLENIPVPGTVYSLVEAPHGLLGSPHLPSNRYYPPRAVGREISVQHLLAMFHPQAFVTMRFPPQGVLACVRAISQSHIAVAFRMHSEFQLNEPPLLPFWFTPSQFAGSLVMSRDGSRVEHLHLFVPTDRRLNVDMEWLNDKDDPESMEVDIGYMPLMELSSAGPSRPKAYMEEAQQVEEFSWDDIAWEQEISEQEARDALELKLFPFKQVKYHNLSEAFTVAQAESKLVHCIVLWGALDDQSCUGSARTLRESALQGPKVMALLHQRFVSSWTLLVDLKAHAADTSLPFSFIAQSFLDIYEFPVTMLVARGNGEVVHQLNANTLLDMEHSLMEHGLSDPSEHNYLQFLKEGIRVAEETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1ADZ1</accession>
    <name>A0ABM1ADZ1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase alpha-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC106013781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012945867.1">
        <property type="nucleotide sequence ID" value="XM_013090413.2"/>
    </dbReference>
    <dbReference type="GeneID" id="106013781"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003080">
        <property type="entry name" value="GST_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF230">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01266">
        <property type="entry name" value="GSTRNSFRASEA"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012945867.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24665" checksum="F369E7D03DD6011E" modified="2025-10-08" version="1">MSAKLYYFYHRGAAELTRLTCVAAGIEYTEVNPETRSDFLKWIEEGKLLFKQIPMLEIDGRQIVQTRAIIRYVARKGALLGKNADEETTVDMLFEGGRDFTTPSLAIGFRPEADVLSNVKNDIMPKYMPIFEKVAAENGTGYLVGDSLTIADLSVLEGLLTFTEYFGKEIFEGFPALEKFFNKVTSLEKISAYLKSPRRKKKNDEHCIAKVKEILGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AEA4</accession>
    <name>A0ABM1AEA4_APLCA</name>
    <protein>
        <submittedName>
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        </source>
    </evidence>
    <sequence length="1505" mass="164793" checksum="39C0E178545ABA37" modified="2025-10-08" version="1">MRSQGLKGTSLEYTDLTEQGHKGHDPKGQGHGDPLDDLRKRRRAELLSLIYEDVKKVTRAPVGTGFPDGRVTELIPPRVVKPGPSFQNPIYFRPRGFSESDASDCYGSFRPDLSRTRKSDSYAIYAEIDDVISDTPILTPPPGFGSWSFDHKMNSDDVFGLTAPPENLQLLRSSSSSPPKLDAASTRRSDQTTAVRSVDCSRGCSREDESFHIWRSPTDVLQMDIQQPASASRPRGEVDRASVRHRHISSSTSCERDGELDYRTSADLGQMEESGAPMSGRVSGEDVFSSQRPCSGSESGGVNERTGIGVTDTSCLDLGTFATPSAHTPRAGHNPSNGSAGKSGKRKKSSEAVGRRPDNKGDSCGRAAVATTEDKRFRETEKLVTDSPDNRSSCSGEQYSKTVENSLNSAEDNHLSESVRNTVERSEDGSEDRLEETSERHPTVSRSRDLNGEGEGRSKKGSDDSGGGQVSVTKNDNSAMCLASNCQHKNGGGVALQAYTFTSWDHVGKWPDSNLPPPPYEPDYTLPRGNFVPLIRFKKLPGTFREDGRDGNYNLTTPSSAVRDLAWYEGEDVETDDAALEELVVREDGVDESSPISLPERSRISLRDTAIQTSLDLDGYAVDISKTLDVRTNGFSKTDLGSEMVQGTGDIGQGNDPPGLAQDIGTGGIQENEKERREEEGGKVKEGKEEDGDNVRDVDDKEEGKVKIDEGKGEIFDRARETEVGSAGDVPDDQGEEESDPTRTKVRRTHKPVTLRSKSLHNQKDNVEGRSLKPEATSLSGSLRELSHLNIDVSQKLVAGQRHYVVENGSADLQVVVNALTPVLSRRNRSRAARRLGHRVTPPDSPAHNDDRRQLNHHQYSSDKTITETQQSAGTKSAPEVNEVMKVQSTERKSTSGAQGASDRPGNDQAVFAAARAGVLGQRNVHGFGRAEEKREDMHVPMYTRLRSHDGTYRPGEGSAEQESTTAALPRLPKRDRKPLYQISDKLSQISKGGKGSEKPREPHREKTREKNGGSSGNREKSPSDDAWKGLDLSSVIEEDSLSKELETSKKSMFLSPKLAHTWHGVSDCAPTRTAPRMGVGVITGDTSRLFSSHHGMQGTGPELPSAPPSRHVTRTLPVISRTLLDALHKRYCAHQYSQHYSVLQPFPLLKRDPAFPTRTQPITALRVEPRPAREHEVVAAPPSPQVLARMRKLQSDGESDTTSSATDSVQSSPRQEHLEEVPAASSLLVQPQRQHSSTDSQSHSSLRLLADTPASLHPPEAGPGGSHSAGEEPSTSRASPAPPLPPRDSPRSSSRRHFLDVRSWSLTPDSSPRQKRLNSGGKQAELEAVEALKWLKAAGFPQYAQMFQDGQFPVELWSVERDHDFLDKDSLQSLFRRLDTLNKYAGMKIDAQSRKKAASEDEEEDDLCALSERWEYQKSVRRWSRKDLHSPTPAPPSAEEADVTEVIDRSASHDSLLADQDSGSQTGDSPLLHPRTAHSSAASGGGVASEETSSRQQQQQQQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1AFI9</accession>
    <name>A0ABM1AFI9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-aspartate repeat-containing protein I-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101859622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946661.1">
        <property type="nucleotide sequence ID" value="XM_013091207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859622"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012946661.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21084" checksum="7DAF63B168675315" modified="2025-10-08" version="1">MLLMLMMLMMLMLMMLMMLMILMVLMLLMLLLILQMVMLMMLMMLMMLMLLKSMLTLLTNVADFMAYDIDAADPADADADNADADGTDAADADADDADVNDAADDPAAITDDDEVDDADDDYDDETLIMLLTLMGVADSDADGDVVYADAADADNADADNADADHAVTDADDADADEADIAGNADDAADSFADDADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQH8</accession>
    <name>A0ABM1VQH8_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="10">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC101848931</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
            <location evidence="1 10">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="10"/>
    <dbReference type="RefSeq" id="XP_035824670.1">
        <property type="nucleotide sequence ID" value="XM_035968777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848931"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="12">
        <location>
            <begin position="112"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="988"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1071"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1243"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1394"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1434"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1481"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1100"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1121"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1244"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1254"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1402"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1492"/>
            <end position="1502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035824670.1"/>
        </source>
    </evidence>
    <sequence length="1502" mass="169034" checksum="547C9D2866DBAF5F" modified="2025-10-08" version="1">MASGGSDDKSRPCSISPRAVSGKVNWKSNSSSEPFSFSALKGKEDGVKKPGGFVCSNFRQPKMQGRGRFQVSTSDKRYQVKPKRLNVQQACKLQQQLMVAFDFEEEDEDRKVIIGICAMSKKSASKPMSEIIRRLRDNFERLQVIMFDEDTILNKPVEEWPIVNGLVSFFSHGFPLEKAIAYKNLRNPFIVNDLEMQCTLQDRRKVYAMLKENNIPHPRYAVLDRENDPDCQVTETEDSIEVNGNLFMKPFVEKPVDAEDHNIYIYFPVSAGGGSTRLFRKVKDRSSIYSRFCRVRNKGSYLYEDFMPTDGTDVKVYTVGPDYQHAEARKSPALDGKVERDSDGKEIRYPVLLSNREKMIARNVCRVFKQNVCGFDLLRANGKHYVCDVNGFSFVKTSSKYYDDCAKILGTLVMRACCPQLHIPYPMCTAPEDIPVVQTASGSMMELRCVIAVIRHGDRTPKQKMKMEVKNKKFFELFEKYGGFKTGHLKLKKPKQLQEVLDIVRHLLAEGQGNADPEVEEKRAKLNQLKLVLEMYGHFSGINRKVQLKYQPTGRPKRSSSEEDLTDSDQGALSPGVDDAPRDPSLVLILKWGGELTPAGRIQAENLGKAFRTLYPGGQGQFEAPGLGFLRLHSTFRHDLKIYASDEGRVQMTAAAFTKGLLALEGELTPIVVQMVKSANTNGLLDGESNTSKYQIVVKEKLKEIFNQDRDFTESDFCKLAATNSISLVNAMQFVKNPFQMCARVHEMIKEITARIRCLKMELKSRDLTLFNGESWELLIRRWAKLEKDFRLKNGRFDISKIPDIYDCIKYDLQHNQKTLQFKRAQELFMCSKALADIVIPQEYGITKEERLHIGQNYCTPLLRKIRCDLLQCINEPTTDDNATRLDSKYSNGVASPERFVRTRLYFTSESHIHSLLAMLRYGDFLDEEKDDQWKRSMDFIGACAELNYMSQIVLMMFEDPAKDEDSDERFHIELHFSPGAYTSCDEVGAEPKGMGFRPKGNRDTINETTTPGNIPEAQEELPETEASVSQPAPTPRPLRHCVSVPDSTICEDLGELVEADLFAHAHQAACRKPSKSDTQVSQRKKSGKFKFQPRSPDPDTPEWDWGDEEEGEVTDEEDNVDQRVKSRPTDLSKNLQQVDSALPGEKASSSQNIPVVKPTNKHPHHGKTEPTRQQSLPPRDQDGASPPSPDSTKLSLSLPKSVEMMLRRRHREDQIGDEHRGGGGAGGQLGPASVRTQPIEINVSPSAESSRASGEEKRSRSLEDSVCDLSPKSGETRWRREARKLHSYLVHLAAAQRNYRTIHLPLGNEVVMKPLSTVFFYHQTPRGVLAVRPALEGFNNVPLLHPLETLHNNLTYHQVDDFLGRVTLNRFAVPDLSALHSIASKSLLKLNSPGKFPDQMPSSSNSSGGPNSPTIQTNPADLIKTLGMYINNRSPQQSEGEEGKLTDTNSSQNSIGDEIQDVEEVTNALTGSLIVTMQGDDLTMPPGIEPDIFDLEDSGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VQL2</accession>
    <name>A0ABM1VQL2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphofurin acidic cluster sorting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101864677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035824704.1">
        <property type="nucleotide sequence ID" value="XM_035968811.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF17">
        <property type="entry name" value="KRUEPPEL TARGET AT 95D, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10254">
        <property type="entry name" value="Pacs-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="2">
        <location>
            <begin position="304"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="543"/>
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    </feature>
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        <location>
            <begin position="556"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
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    </feature>
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            <dbReference type="Pfam" id="PF10254"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035824704.1"/>
        </source>
    </evidence>
    <sequence length="727" mass="81153" checksum="89216FBB44D6823F" modified="2025-10-08" version="1">MDRDLNLYSDVKEQTNPVAKLRLLALSSQPADHEINGHQKHATSDVGVPILPSSYRSPDIDNDSDDDDVPEYNDYSSNDDMSDSEPTMTEHEARARQRKHSRSKIGPGVTQRNIKQKFIALLRRFKVSEDVLTTLDSEADHDQIPNPQELDDLFFELEDSDSGPELDTMSVMSTPKPKLRPFFAGRGTTPEASDHLPKTPSQEVFRSLEDTPVKRSDSDLHTTVVSTLCQERFSDLDFEASDSQNASASESSPKVHIPRPESKEFVRDRIRSTSYREKKSKKEFKRQHRRNSVGEDVSLPRKALLDQLSLVFDAADDQLPDAVFMVSTAEWQGQMLAQKVQDHQLRLICTCTEADVKAAICFLVTKIQKFCNSNARTPIPIKVGVVGGDAYVNSVLRPYVEHFASKSPDWQNYTRFLVIPFGPSSIGKYIASVDSTFGSLFMDLQWKDTFEKPESPKLDSQDIVNRISKYLNGANSLHQMPIAEALIMCKGRSSDEVSSQIFIPFLSEVRIGTLDNFNSSVEIEDSLPPVLLSSSPPASTPILEKTKEGHTPPSSPNIGATMSPPTSNSGTALSSISSPAEFMDLQVDYWVMSPPKSDAVDKEKDKDKKEKKDSNKCSLKSAFRALYANRLPHSGGVQSSTFSMMVVTKEKKQKIMRIGKKGKDLESKSQAIEGVSRMVCTSKSQNIKLRVLVDGVEWTGVKFFQLSSQWQTHVKYFPVSVFGSMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VUQ2</accession>
    <name>A0ABM1VUQ2_APLCA</name>
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        <submittedName>
            <fullName evidence="3">Arginine/serine-rich protein PNISR isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101863476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
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            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826144.1">
        <property type="nucleotide sequence ID" value="XM_035970251.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031937">
        <property type="entry name" value="PNISR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31518">
        <property type="entry name" value="ARGININE/SERINE-RICH PROTEIN PNISR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15996">
        <property type="entry name" value="PNISR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="280"/>
            <end position="379"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
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            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="323"/>
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    </feature>
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            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
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        </location>
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        <location>
            <begin position="605"/>
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        </location>
    </feature>
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            <begin position="628"/>
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        </location>
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            <begin position="638"/>
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            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
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        <location>
            <begin position="679"/>
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        </location>
    </feature>
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        <location>
            <begin position="710"/>
            <end position="814"/>
        </location>
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        <location>
            <begin position="834"/>
            <end position="965"/>
        </location>
    </feature>
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        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826144.1"/>
        </source>
    </evidence>
    <sequence length="1068" mass="121754" checksum="0A4B47723645235F" modified="2025-10-08" version="1">MWANPFGTGWSMQQADYQNVPHDQVDWAALAKQWISHRENVTNTGGAMGSAEPAAPPVDVMTVAPPPPPPPPPPPPPQEDVNSPQQQQQAPKTEDENSMEIASDGEDNAAPVVAPVMPQAFVAPGMWGMQQQQQQQPWWPAAEQTPEMWMGQQMMPAKDGFGGDMSGFAPGFPAENVYYNQQDMPAKDTAYPSYWEDSAGVDSDSSQAGLLPDHAARPQNHHHHRHHHHHSHHHDLHRPSRPDMMRHGQMEEGEESSLDAAKRRALPVWIREGLEKMEREKQKQLEKEQMKLQREAFLKEQQEENTKAGKSNADKNPLRSKFDSDDEDDKEAQEDSDEVDSDVDKKPRSRSTSPSQSKERKASVSPKRSPSPSAFMTEEEKEMALMLKVKKMLTETLLEVTNQEIRGVAKEVHEKARKKALKAPARQLAKSSALASLTSLGLGYGSDSEASGGEDRSGADDDSDSDLEEKIRRKKEEFAKRQRIFSDAEDDDYKPDLRLPSKRKVKEEEPSDKAVKEEDENISKKHSDRADRRSSKDVKESKDKKEDIAEAENDSKSKKAQTNHKDSHVEEESEKERRKSSESKNHRGQERKTSGDANLDQDNANADRDRKSKEKKISAKVVEESGSSKKRGSSKSSKKLEGKKGSGHNRETSSGSSSSSSDSDSNSDSSSSSEDEGESGNSSSSDSESSSSSSSSSSGAEKNVKRKKKEKGERLKSLEEEKQKGGRKEVAKSKHSEVKLEGEKRREKSDREAVGKNSEREGDTHSEKKDRNVSERKQRDKNEGEVVTEKKPKSSQKIDDEERQLSDSEMSRSDRHNKKNKKSSEKRKSNRSPSVEERRGDKSKGRSRSDRQSRERESREGRRRDSRSDSRDRRQKDRYEKHRDRDYSDDDRDRRRDRDREYSDEERDRRRDGDSSRSRRSRSRDDRGRSRSREDRDYGKRSRSRDRDGARYDRSSRRSTLDESYKSSSTSKSSKKRRRSRSSSESDGSVRRRSKKKESSPSERKKHKSSKRRSKDGYEEYGDVDYEERREAGKTSKGKRNHRSRSRYVLHSILLTSLKHYKCLCRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VVB2</accession>
    <name>A0ABM1VVB2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101862588</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">LOC101862588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
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            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826354.1">
        <property type="nucleotide sequence ID" value="XM_035970461.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862588"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035826354.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17224" checksum="F0A98BB903B570DC" modified="2025-10-08" version="1">MEQQLSEKRKKTKQNKSNTINDSSYGSMITGTSSSSSLSLSLFSESDLAEAPSTSGCSSEMASAMQSKEKKKERAKEFMKKLKSMLPMKERTGKMDTLSTLEQLVNSMRQLNEEQKRGSEFKTPPPHNGSYQGNDALKLHKVGTCIVDFILLPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VW09</accession>
    <name>A0ABM1VW09_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101854179</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101854179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035826601.1">
        <property type="nucleotide sequence ID" value="XM_035970708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854179"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="691"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035826601.1"/>
        </source>
    </evidence>
    <sequence length="860" mass="96617" checksum="80E68F3FCD0F312C" modified="2025-10-08" version="1">MIMFCLSSSRAIPGKRRRRRRGRSDLNNGEERLQANRSRFVVDDEGLTVRSTRSWSSSSSCASFPYNNYGNSADRDVFKLVVVQGGDGGSGEGGERGEGEKRHRGAGGSGERGVRGEGEIKQRGERGEAEGRNYSSRNEEDEFYNDKDFLHQHTNDSARSSGNRDSSRSSNRCSVSDAGFDRWMTRHYTYSSYNPSVNGMGEDTATVSTCHSSDYNLTMPAITNFVLEGSKVQDPKNRPNQTSQGKRPTESMDYEPNPDVVPFQPANFIRSNTVFPPPFQRSSTILKKVPIPKRHLDTFGGYEYNFIGRRGVMLHTDRYQQNPKEKEKTKDQEVDFIKSFDGMTQRERLQAGIEYMEAMRGTRRRREMVPHRAKLDLIMGGKQIEFEERFDIAREIQKLKAIAMPKHAKDLFHGRGIHLPNNHLSVHPHPRLPMPNDLEDEVTGSAPPSMQNFYRRPLGGTTAQSGLLHELPPLDGTDSQSSFMTPGGFKRSKTKFVKHPQLPGIKGKTDAADFWDQNPRVSMFRERRTVSNLSARLGFFSRLHREGTNVSRSTGHAPPPSRDPSNDPASLLQRGAAGPPPPRKTTIPAAGAHGTDQEQNLNTARDSELTAPTATSELASSRQKEKGRGGANETEDPAPGFPLTARTTPVLPQIPPISSESKVRPTTEEKQKPTTPHPLRGVELITSVPQDEQEELRQTFQRLDTDADGHIKYQQLKSHLPKHFSFEQEKFTEEVYNMSNSITFFGIEEFMIMDRLSKTVENLTDRAAESFSALDFSTLPRDLLKYLGKFDEADTGNSGKISHDSLRRILSDTVGDQVTTDPALWDNIQNLINTESTQVTKIEYIAHIPLYLSFEKEHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXN6</accession>
    <name>A0ABM1VXN6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transforming growth factor-beta-induced protein ig-h3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101846229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827179.1">
        <property type="nucleotide sequence ID" value="XM_035971286.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101846229"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="126"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827179.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32444" checksum="842DDFDECD9A6640" modified="2025-10-08" version="1">MRLSKFMELVAAAGLNMTLDNGGDVTVFSPTDQALGNIPPKYMASLRNEPRKMKELLQYHMVPGKLEESTLIGDTNLDTLANMALKIKVTVLRDGVKLDKASLQNHGRECRNAVIHRVDKVLIPPDNSLMDELMGDPNLSEFWQMMDSSGVSEELIPFGSYTVLAPTNNALSKLDQRHLAKMKANRERLKQFVLRHVILRTVLKCAVPEDGTYNIKSMQGDETHFTFDWKDRLVVNKHSRAVSDDILTSNGILYKIDHVIPCSCEKLMRTRRGQYLSAHRYRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXX0</accession>
    <name>A0ABM1VXX0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Four and a half LIM domains protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC101848452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827263.1">
        <property type="nucleotide sequence ID" value="XM_035971370.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827264.1">
        <property type="nucleotide sequence ID" value="XM_035971371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848452"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF4">
        <property type="entry name" value="PROTEIN ESPINAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="104"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="166"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035827263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035827264.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32841" checksum="E94E34196F0A4A91" modified="2025-10-08" version="1">MEQNFHKEHLACWNCDKQLVACRYILKEEHPYCIPCYQQLFAHNCEECTKPIGPDYKDLSYKERHWHEFCFKCCSCEQSLVDQPFASKNEKIYCSNCHDNNFAARCDGCSEPFRGGMKKFEYKGKQWHDECFTCTECSQPIGNKSFIPRDERVVCVQCYENNYAQRCSKCSDVINKGGISYKNTPWHRECFTCTNCNKLLAGEKFTSKEEQPFCGDCYGELFAKRCCRCTKPITGIGGTKFISFEDRHWHSDCFNCYKCEASMVGRGFLMNGEDIVCPDCGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXX5</accession>
    <name>A0ABM1VXX5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6" type="primary">LOC101851211</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012941458.1">
        <property type="nucleotide sequence ID" value="XM_013086004.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827267.1">
        <property type="nucleotide sequence ID" value="XM_035971374.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827268.1">
        <property type="nucleotide sequence ID" value="XM_035971375.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827269.1">
        <property type="nucleotide sequence ID" value="XM_035971376.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101851211"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_012941458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035827268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035827269.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22966" checksum="86B5A60D73EDBF4B" modified="2025-10-08" version="1">MSDLIFISKDLTYHPQTRPRSLCARCSTGRTNRQHTSPGRAAWVAGEKGRGLSIEREGREGRSNRRRHASASNGDAGGQRSPSYCYVVPLSEGANGATSRGSSSTTYREDFKSPRDPKSARDLFLKRQIQSNPSSPVSSSPWATSPSSPATTPSSLSAFLPSSRRNRSTSYQSPSRNNVDVKKTSSGLSDSQPNFRRKTTYTDHYTWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VXZ2</accession>
    <name>A0ABM1VXZ2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acetylcholine receptor subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101860352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035827285.1">
        <property type="nucleotide sequence ID" value="XM_035971392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860352"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="194"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035827285.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47761" checksum="04B1E136E37F54CE" modified="2025-10-08" version="1">MASDFCCLEIENYTPRNNINEVIESKQSVSSVVFFNVTWTDEDLAWDVEDYDNITMATAPPDRLWHPEIHVANTLDDLVKVADPYYLQLSSDGTVQFEVATTLRTTCPFDLTEFPFDTQDCGITMVLKGFDIHVRPSVDDIRIIEDGSLNLIFTKTEWTIESSEMDVLTLNNEKPLINLRVTIRRAHLYYTLCVILPVMITSWVSLLVFWIPPDSGEKMSFLVSNFVSLTLYFNFIGDLLPRNFTEAPKMGILFVYICVQCAVAMVITIVVMRKHRQEVLEAELAMTLTAPSGMAPHPDQLRPVNQNKTMIVDDGVEPIPLRTLTPRKVTPNTTAEQDQEHYFQQQQQQQQQQRRPKLRIKRFLRMNSFEASEPSCWERNIARQDYFSAAAIDRICFCLFSLFGVLFHIILFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VY29</accession>
    <name>A0ABM1VY29_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Secernin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC101860915</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104829.1">
        <property type="nucleotide sequence ID" value="XM_005104772.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035827322.1">
        <property type="nucleotide sequence ID" value="XM_035971429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860915"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827322.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45061" checksum="278F619780DE9FD0" modified="2025-10-08" version="1">MADLFVALPPVTSFGAVLFGKNSNRPASEIQDVVNFPAKDYGSGEKVKCTYIEVDQVGHTNAVVVSKPSWMWGAEMGANDKGVAIGNAPVWTKLNGPQDLEKKLLGADIVRLSLERSSSAREAVDVIAGLLSTYGQGGPCTDEPGEDGWSFHNSYLLADSSEAWIMETVGSLWAAERITDGVRNVSNELSITTKLDLSSPGLVDEAVKLGLYSPDKGPFDFKAAFCAQRVSQTGSVHSTSFRLRHGKELMDKVVTKGKFGYRDLLSILRDEDGGICMMDGGFITAGSQVSVLLPNSSPSPNVHWFTGTPNPATSIYKPFFFGPGAEVGTVTVSPPVEAGADQSETGHALYRGHKRLCMLMDSQEEKGHSVLKQLRELENKCCEDVDEIVASYSEASFPKLKQIFQHMASMELNFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZ48</accession>
    <name>A0ABM1VZ48_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101857050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101857050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827691.1">
        <property type="nucleotide sequence ID" value="XM_035971798.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101857050"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052876">
        <property type="entry name" value="Insect_Hormone_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39940">
        <property type="entry name" value="PROTHORACICOTROPIC HORMONE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39940:SF1">
        <property type="entry name" value="PROTHORACICOTROPIC HORMONE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045664369" evidence="2">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035827691.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19942" checksum="A559B5D441EC0083" modified="2025-10-08" version="1">MAVSFLVSLWLCFTMSVLQAYLPVNVASLELPRHLSSSDKPSRTVSDSAIKYLMSHPLHRNAGSPLETVSVGSQQGESAPNQHITVRDSEPLPWMCTQRRTWRSLPVGYYPSRIAETVCESSTCMSGHYNCTAVTYNTQVLQFCYNANCNDVRIPYSMRRFWKFTDIPVSVGCMCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1VZT4</accession>
    <name>A0ABM1VZT4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Keratin, type I cytoskeletal 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101854821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035827927.1">
        <property type="nucleotide sequence ID" value="XM_035972034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854821"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035827927.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="26260" checksum="38C0270069496EC3" modified="2025-10-08" version="1">MSFGQPSYPQYPYQSGYSVPPQPQPPSLMSQPPVAPASAPPAQAPGAYPWPQPPPSTATARPPRGRGRGRGAAATPPTSASSYTQAPGGYEYDYTYKGQESYAGGYGNGSGGYGDGSGGYGGGSVDYGDGSGGSGVYGGGSGGYGGTAGFGSYDYEGGYGGGDASGYEGYHGGYEGYEDSSQWGYGGGGEDFSYGVTYGGGYAPSGGASRGWGTTAARGKRGGRGAFGGGRGGFSAGLEAQSGAADSSFSFGAGSGGDDGGEGGFPRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W0M5</accession>
    <name>A0ABM1W0M5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Protein phosphatase 1K, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC101850364</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828217.1">
        <property type="nucleotide sequence ID" value="XM_035972324.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035828218.1">
        <property type="nucleotide sequence ID" value="XM_035972325.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101850364"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="110"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035828217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035828218.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="43586" checksum="84325710C0168FB6" modified="2025-10-08" version="1">MFAIHRNVTRKVPENCALFAKALRKSVLFGDKPERVNQHMCLRCEKAFRSIFSSSQNAANYISDPENKGKTTRGVNFDTLGVWNNRMVLPILYDQSIKKGKIIPKVPIDEVALASVIGRRKDNEDRFVIEELLPELLYFGVFDGHGGDFAAEYVSTHLIDHMGFWMTQTKDLKTVLKNAFCDVHNLLARHLVFYHIDDDNFKTGTTATVCLLRNSTELVIGHVGDSVCILCREGDPLRLSVDHDPENSDESHRIIGKGGRIIHNSHGVAHVNGRLAMTRSVGDVELKSFGVTAHPYLKSIEIKHGKDAFLVLSSDGLSFAISDQEIVNIVSSCQTPKEACSRLLDQAQHFGSEDNVTVMVVPLGAWGKYQKSSSNTQYNFGRILSHSRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1P5</accession>
    <name>A0ABM1W1P5_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Gamma-aminobutyric acid type B receptor subunit 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC118478661</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035828588.1">
        <property type="nucleotide sequence ID" value="XM_035972695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118478661"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="12">
        <location>
            <begin position="262"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="576"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035828588.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="74696" checksum="16943EF1F4C4518A" modified="2025-10-08" version="1">MSGMQAAESTVCACVCACVSSRGSSVQVSNDVTNRSCPRPPAQTQYSREGSPAPAPPQARCQRSRSRLTSREYTLCRLTDVLRKISDVGKESCNTISSLSRDSHQMTICDVPGSNVNSARVEYDYDYDYTDESDPFWEYRLWKEQSAMGKGQKIGEKPPAAPDPILSEGESDTLSSNRAGNPKDRSSLFGTGQTWQNRPKVSGLEDTTSHPPTTSHAALDLPAGAVGRGVLPAVHIALQHVNNDTRMQRKYTLKMASNDTKLSYADTNPMLSDRDKFPNFYRTVPSDSDFNPARLALLRHFNWTTVATLFQDAKLGRARYGYAHNRFDSLMEKNKINISIVESFADDPEQAIKNLKAHDVRIIVGNFDQSMARRVFCSAHQHSMYGAKHQWIILGTYDPDWWTVEDDSIPCSPQQLNHTLHGYLATDVLPLSTSDEITESGKTSGEYLELYESARGQEFSKYHGYAYDGVWVVAKALDRLLDGTSMTPDLFRGPLVGKVLNETSFQGVTGRVQFLNGDRVGSTTILQMQFGSMEKVGEYHALYDSLDFSDGKPIVWRDRKPPVDRSIKIDELRHVSVPVYIGLVVMAAFGITMAVLFLALNIRFRNHRYIKMSSPNMNNLIIIGCILCYVSIILLGADPDHHNPALFAYLCTVPPIAIACLCLFLQGLSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1P9</accession>
    <name>A0ABM1W1P9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hyphally regulated cell wall protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101862837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828592.1">
        <property type="nucleotide sequence ID" value="XM_035972699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101862837"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046726748" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035828592.1"/>
        </source>
    </evidence>
    <sequence length="1299" mass="134046" checksum="67F55B599A6FA98D" modified="2025-10-08" version="1">MSKLSTLGFLVAVLAVCALDHLTTSASVGRVIRQISNGSSPNGTHRCIPDLTFHYNETTGSWQAVLPPVPVNGSDSNANSTGFSPIPVKVSSNSTGFFPIPVNESVNSTGSNANLTNSLPLALNGSANSTKFVVNGTDSNAHVTDFFLGVANRSISSVNSTDFVPLLVNGSANSTDSDANFTNHVLLVVKGSANSTGFFPQALNGSANSTDFFPQALNGSANSTDFFPQAINGSANSTGSNVNFTNSVPVALNGSANSTNFFPVSVNGSANSTGSNANLTNSVLFVVNGSANNTNFFPLALNGSANSTDFIPQALNGSANSTDFIPQALNGSANSTDFFNRTVKRSDSGANVTDFFPVSVNVSSNSTGSNANFTNSLPLALNGSANSTDFFPLAPNGSANSTNFFPQALNGSANSTNFFPQTLNGSANSTDFFPQALNGSANSTDFFPQALNGSANSTDFFNRTVKRSDSGANVTDFLPVSVNGSANNTGSNVNVTNSVPLALNGSINSTNIFPVSFNVSANSTDSNANLTNSVLLVVNGSVNSTDFFPVSVNGSANSTGSYVNFTNSVPLALNGSANSTDFFPVSVNASTNSADFLVFALNGSDSNVNSTNFFPVSINGSVNSTDFFPQALNGSANSTDFFNGTVKRSDSGANVTDFFPVSVNVSSNSTGSNANFTNSLPLALNGSANSIDFFPVSVNGSANSTDFFNRTVKRSDSGSNVTDFLPVSVNGSANNTGSNANFTNSVPLALNGSANSTNFFPVSVNGSANSTNFFPVSVNVSANSTGSNANFTNSVPLALNGSANSTNFFPVSVNGSANSTNFFPVSVNGSANSTSFFPVSVNGSANSTGSNANLTDSVLLVVNGSANSTDFFPQALNGSANSTDFFNRTVKRSDSGANVTDFFPVSVNVSSNSTDSNANFTNSLPLALNGSANSTDFFPLALNGSANSTNFFPQALNGSANSTDFFPQALNGSANSTDFFNRTVKRSDSGANVTDFFPVSVNVSSNSTGSNANFTNSLPLALNGSANSTDFFPLALNGSANSTNFFPQALNGSANSTDFFPQALNGSANSTDFFNRTVKRSDSGANVTDFFPVSVNVSSNINGSANSTDFFPQALNGSANSTDFFNRTVKRSDSGANVTDFFPVSINGSANSTGSSANFTNSLPLALNGSANSMDFFPLALNGSSNSTGSNANLTNSVPLVVNGSANSTGFFPSAVNGSANSTDFFPVSVNGSDSNTNRTDWKPRIVQPVTTDAPITTSPPDLPDDIFPSISEAEEEALWKLLLRNILSRWRLFRAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1Q9</accession>
    <name>A0ABM1W1Q9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monocarboxylate transporter 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101860052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035828602.1">
        <property type="nucleotide sequence ID" value="XM_035972709.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860052"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035828602.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40151" checksum="882AB9AC2B54BAB2" modified="2025-10-08" version="1">MTVESSRNGGVDSTRLPQDDSSKKVSHQNGEISRPEGDKTLNERRFSQDTNGLDKTEDVLLKLDDGRIQNSPGGQSLDKPVPRAVSDTNLASDAATTTQCGDQNRHQGNLADDNTHDEKDSAKTLWRKSSRDGYSSPSKPARDSDDDDEDGDVENGNDRISEDPVPYDKGWAWMITLGAFIVLLLVPGYHVVMSVMLLDIVDHYQTSVTMVTVMQSLASLTFCFSCQLSMNLLLPQTSFRVTTVTGAVVNAGCTLLMTFAPSMEVFTLLNVLKALGQGGMVAPALTLVGLYFRRRRALASSISLLGVSFASILVPQLTGYIKEQYGFSGCYLLLSAYELHLRLKNQQSTISDVLQRNAKTERRITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W1W7</accession>
    <name>A0ABM1W1W7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetylcholine receptor subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC106013357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035828660.1">
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    </evidence>
    <sequence length="1755" mass="188855" checksum="F4EB614996952C12" modified="2025-10-08" version="1">MLVFNAVLTGVYMNVRTLTSSLAHLEVMPPFVPVTAGGLAGLSILLLFWKRHKILVYPALILCVLATTLCVICAVLSGTHVLQPLLAVSSCVYTRRARSCRCASRYARDGLELEKLNEGDLSYVSYESVSGCDVVEEVLPYMLFTMIGIYAVVALVCVVAAVISFLVYRTERQRRFLEEDDDDVDSLSGPSSPGSSENYSEHHTMLPTQTPSSDSTTLVNIYTNANATTNDEDNNTNDEDNNTNDDDGNTTPSDLIYSASDVPMGYAEACRMRRCHSFSQPRRGAGRGAGLGAGREGSPGSSSSSSQTTSSLIGGDAGAAGAGKLREHRKKGRRAVTLHGLDREQLMLILSLQMRYMQETDQSTKRPETDNPGAAVTSGQLANSCGLEASSPASDSSQESPPDPAHMFAQLQRRAMTPTPRQERLSSSRTTDDDLDYRPSKLVRSHTPQPYHFKQAAAPSTVPYYQSPSQIQQQQQQQQQLQQPFIPDYLQQQLWHPAQQQQLLQQQHVRQQQLLQLQQLQQQQQQHFQLQQRLVQQQQVQRPPQLLSPQPPSLSLEQSACPQQQQNGNVNNNNNSNSNNVDNDDDDDDDDELPTLITYDLRNVAKSGPIVYENLPPPKHSQIHNNYYSNTTINSNNINNNTDDSAASSNTSSLLRTPSSPAHLRSQPQLQPLPQQLQQQPLTSTAGVTTDLLSQHPVLGGNVQGMNQHQQQQQQQQQQQQQNLTPPQTAKLGNTAATASAAGASITAAAADAKKSQQQPSTDSKSAADSNSSKNKTTSKKKLSKKEKNAKKKGGGGGGEDEENEAASQQQQQQQQQQEQQQQAGKATVTRTDSNTSRGGSGPSSDRWQAVLSDGAAQGQTLWENVQRKIVSDPAELPDPSSSPSSSVLLSPSMLSSSSSMTTGVLAEKNSVTSPSSSHLPVGPLHHPASMSSLSHSSSAAAGPYNGGGNASHLGPTQKTVPNGILKNSGGALPSSGQRAGVAASLPPPPSHTSLPPPPPHNALPPPIPAPLGLMSGPLAGYPLGQLTPSLPGSGSGHAIYPLPENQRAFVPIAHSSTSTNNYEDIDSVSPPSPPPPPPPPPSSTTTHPTRHTVPTPPPKPERKHSRKGAHPNNSNNNSNNKSGPEDGQQPVLRPKSYLNAVDAMSGRGVADGSHGNPESNTTTSTTTAAQKNNVSQKVLTHLAMEGPVRDEDRTLNPPVEDRGHFVSANGDIYAQARRKASPKSIPQIYQNLQQRSPVPMESNPFPPPPPPLSPQQQHHHQQQQQQQQLQQLPQYHPHHNGHLPRGLPQQHQQQLQQQQLLQQQQHHLPYPQIPPPSSSSSSPSPATSSSSPHSRQTSSAFHSLESRMGPSPSPSINEVCDTDLDELPTPRWHRRQQLRSQSFSPPPYSPPPLYQSMDSINPRSSVRSTSSSSSEAHNTSYTSSERSCTPLGDPYFPRLHGQGQGHLGQGQGQGHPAFAVSHPHHPHPHLQPPHGMSRGRVPTRSDHRRMEHFPPSYHHPHHQQPSRPTQNVPHPAAHNRFGPYRDNNILQDPAVDDNIYNNTTNTTNNNNDSNSNNNNNGSNSALAQGQGEPYMLMRRCQSVEEGRGQTSLAQGLGGYNSQRGRATAAQTAGGGGFYQPSIDPLKPQLRNSPNGHLPAAAFENDLYHRGQGSQPKILRQMSQPGSSGGSHSNGSSNHHLNCNNGSNNNSSSSSVVAVVGGGGGVRRAGGLESGLTSGVRTPDLAGYMGVVRLTDSGGGGDGGGVDKDFAETVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3N9</accession>
    <name>A0ABM1W3N9_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101860866</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101860866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035829282.1">
        <property type="nucleotide sequence ID" value="XM_035973389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101860866"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035829282.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14402" checksum="2BC0C27C6C0AA179" modified="2025-10-08" version="1">MEAFMGVWRFNSSTISGDADPMLNAVILPGVTPEDLQQGGEIEMTAEGKTLTIITRPPGRVEIVDVLVLGEKDVRDGPGGVKVETVGNWETDRFVSTSHIGDVTVRTVRYLRNGDMINETSSGGKTVTARLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W3U0</accession>
    <name>A0ABM1W3U0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Gamma-butyrobetaine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC101859751</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005112349.2">
        <property type="nucleotide sequence ID" value="XM_005112292.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829333.1">
        <property type="nucleotide sequence ID" value="XM_035973440.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859751"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="6 12 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="10">
        <location>
            <begin position="85"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="9">
        <location>
            <begin position="201"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005112349.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035829333.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="54633" checksum="83C60740DE26D160" modified="2025-10-08" version="1">MLRRVVQASLSQLKRQEFKAANSQSKLCRTLWGNRLIHTTCCRSKAGSVNPAESETGHLQGIRSRGFYLEDIYQHVKSTDVQDLQIQEDGKRLQITWDDGHVSRFHSIWLRHNCHCEVCLPHTSTVLVDFSKIDIDLRISSATMEGSEVIVLSWKADSGEAYHEGPILTKFLRYHCYSDAADNARRAARAMHFPKDKSIPEVDCAEIMESDEGLYKWLLALSNYGICLVKNTPTKRGTIAEVAERIAPIQHTIYGDVFDVESDPKPMNAAYTGIALDLHMDQIHYESPPGLQLLHCIEFDDVIQGGENFFVDLHEVAHKFKKEYPDLFYTLTRVPSTANTVDYNRDFPAHVRIQRPLITVNHKDEIVSVLWQPMLIAPLQVPEKDVEPFYKAYKQFYTMIHYHDAMYTNRLRPGDMISLNNRRVIHGRKGFTENGRRLLQGCYINISEFQSKVQIFHNKYGGGRWPTRCGSMDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM1W4T4</accession>
    <name>A0ABM1W4T4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Trichohyalin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC101847174</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012946712.1">
        <property type="nucleotide sequence ID" value="XM_013091258.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035829677.1">
        <property type="nucleotide sequence ID" value="XM_035973784.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847174"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025259">
        <property type="entry name" value="CCDC34/181"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13904">
        <property type="entry name" value="CCDC34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="2">
        <location>
            <begin position="509"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012946712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035829677.1"/>
        </source>
    </evidence>
    <sequence length="1205" mass="133381" checksum="EB0559E2887892AA" modified="2025-10-08" version="1">MASGGSGDPSPRVLAFLNRLVDPAAAQQQEKTDSDKENEAGLMTIAEEEPATDSDDRPRPLSVKRNGDSAPGEGGAGFNSGNSASSDLNNKKNEEDKMWDDFYNDEEFTAKKDIPSPSDIEVPSWAKYSVSDDRTRDNEEGGGGGEVDEEEDEDEEEEDNSKSQGAGDEMAGSEDASASPRSRATKRKRKRLFRKTARPPPPSGSSPPTVTGGSHPDLGRPERERHTGHQMETMSESSGRGGRRLSRRKQVARPRVAGPEPDGDRLQQKYQELRHLMVKPLVTPAAAQVQQTRQQLRRLHGLSSQYGAVAHTTAHNSSNSSLPPAGGATHSRDRPPRQAFVELGQGNTENGYATIRTVQLTNKVGGVTTTTNRAGGMTTTTTTNRPSTAHAHTRSNSNNSNSNRRPQSGTRRPASATTAARREEEPSTSDAGRRLTRAAADRNSDRLGKNGGGKVVRSDSDRSTSDSFRNSVRSEDYSKNEASSDGEERLRSGSRSPGRAVQPSDTHLKNSSNPALRKWLKQKDKEHRRQKAEERKKKREERTQKQMQENKKQEHLEKAEQRVKEWMSKKRREAYRQAKEDRRRRRAEAEEEEKRRQMQPDYSNIFRARSAERPKTDDGEQTGGALSGGEGSVAPAEPPKSKFVYKRPVSGRVRLMKLQQERKEDARRSEKEKRETEKKMEEEKAKKMRMSYDQWLLRKREENYAKRQESARQKAMARSDPELERIVPEVARRRIDNIKNGRKRVDTGIRKINDEVNKSFGGADYGADKSDNEETQTTNFLEVSGAQKSLRQRPSSAKHAQNNGLMNPMISKSPRRPKSANPRVQALKEADGDGKKSEKNAFRLPFPPEKGVPRHVDSRQKKLFSAILTEDSGSTANDESVEIGQETDVSQDTSMAVEASDVTAAKSRESEDDNEVRDEQKAERDGNLGETGGENLQGESGDNTADDGDAADDGDDNGDDGNEKAAKDDQNEAFFVTEGNLEGAGGGNDGEGDNKETSEDVSAEEQVATSEETETSGEAETAQQLGEGAEATDEGKEEGDNGGISQDLGVGEEEVLENKGDNIPSSVEGEEQIETPSQHNDDETAEDREEKAEGATSVEASQDDRTNLSLNLDQEEEEEVEEGEIQFEEENEGGEQKEGMDDEAFFDGKRSESRGPSKHVSFQEETEIYEPVDLSFDKGDEDEDEDEAEDERGDHFDTPRDDDEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>P49395</accession>
    <name>RS3A_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">40S ribosomal protein S3a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Lysine-rich protein KRP-A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RPS3A</name>
        <name type="synonym">KRP-A</name>
    </gene>
    <organism>
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Eur. J. Biochem." volume="220" first="997" last="1003">
            <title>Analysis of genes encoding highly conserved lysine-rich proteins in Aplysia californica and Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Auclair D."/>
                <person name="Lang B.L."/>
                <person name="Desgroseillers L."/>
                <person name="Forest P."/>
            </authorList>
            <dbReference type="PubMed" id="8143753"/>
            <dbReference type="DOI" id="10.1111/j.1432-1033.1994.tb18704.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <tissue>Neuron</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="X68555">
        <property type="protein sequence ID" value="CAA48558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S43541">
        <property type="entry name" value="S43541"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P49395"/>
    <dbReference type="SMR" id="P49395"/>
    <dbReference type="EnsemblMetazoa" id="XM_005096114.3">
        <property type="protein sequence ID" value="XP_005096171.1"/>
        <property type="gene ID" value="LOC101856798"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000153527" description="Small ribosomal subunit protein eS1">
        <location>
            <begin position="2"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="265" mass="29660" checksum="A915463A3FC37F12" modified="2007-01-23" version="2">MAVGKNKRLTKGGKKGAKKKVVDPFTKKEWYDVKAPSMFAVRQIGKTLVTRSQGTKIASDNLKGRVFEVSLADLQNDEVTFRKFKLIAEEVQGRNVLTNFSGMSLTRDKLCSMVKKWQTLIEANVDVKTTDGYLLRVFAIGFTKKRNNQVKKTCYAQHAQVKAIRKKMVEIVSREVSSNDMKEVVNKLIPDSIGKDIEKSCQGIYPLHDVLIHKVKVLKKPKFDVGKLMELHGEGSTTTSKGVTSEGGEKVDRVDGYEPPVLQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-10" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2VTE8</accession>
    <name>Q2VTE8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11 13">Pannexin 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100533404</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2006" name="Cell" volume="127" first="1453" last="1467">
            <title>Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Edwards J.R."/>
                <person name="Puthanveettil S.V."/>
                <person name="Kohn A.B."/>
                <person name="Ha T."/>
                <person name="Heyland A."/>
                <person name="Knudsen B."/>
                <person name="Sahni A."/>
                <person name="Yu F."/>
                <person name="Liu L."/>
                <person name="Jezzini S."/>
                <person name="Lovell P."/>
                <person name="Iannucculli W."/>
                <person name="Chen M."/>
                <person name="Nguyen T."/>
                <person name="Sheng H."/>
                <person name="Shaw R."/>
                <person name="Kalachikov S."/>
                <person name="Panchin Y.V."/>
                <person name="Farmerie W."/>
                <person name="Russo J.J."/>
                <person name="Ju J."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="17190607"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.09.052"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AY823630">
        <property type="protein sequence ID" value="AAX24146.2"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191616.1">
        <property type="nucleotide sequence ID" value="NM_001204687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2VTE8"/>
    <dbReference type="GeneID" id="100533404"/>
    <dbReference type="OrthoDB" id="6156233at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAX24146.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="NP_001191616.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47332" checksum="1759134328E5AEF8" modified="2006-04-04" version="2">MPFQQRSLGEDSTDRYVHTWTVSLLFFLSLVTWLLAASPLVISSGEGTPPFQARCWCPAQFESSQVEYSNAFCSTWYSDAFKRGTLRGLRDLLTSLVSFKPEDSSILDYYVTTNGSETFNLDSSDQYFASVTVPLVLFIFALLIKLPHLVWYLMSTFCPVNIEKTLHTADHVQNLQTDTKRQVTTDLVQSVDKALKDCPHRATVSYLFYKFFSSLVLVLESTVLSTRILPQVFAETGSRQPIQQQSEVLPCYFTIRQLSNHHDYFLQCLFSPTDTSRRSQLGHHALFTGLLVYFLILTVVSVVSFLTWLSRLTMGTCRSQVAARPSLPTDAYLLLYLSQDNLGPMVTRDLAENEAWTQDSGLAGPIVASGQFELDGQKDGAEEGDQAGEGGGGEGAEEKMDSEKEKDEKKDDMTVDLDKVDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I6M6</accession>
    <name>Q8I6M6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="19 21">Tandem pore domain potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC100533285</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="book" date="2002" name="SOCIETY FOR NEUROSCIENCE" first="335" last="335" publisher="Society for Neuroscience" city="USA">
            <title>Modulation and distribution of K+ leak channels in molluscan neurons.</title>
            <editorList>
                <person name="Unknown"/>
                <person name="A."/>
            </editorList>
            <authorList>
                <person name="Jezzini S.H."/>
                <person name="Bodnarova M."/>
                <person name="Lovell P."/>
                <person name="Moroz L.L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="19">CNS</tissue>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="journal article" date="2006" name="Cell" volume="127" first="1453" last="1467">
            <title>Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.</title>
            <authorList>
                <person name="Moroz L.L."/>
                <person name="Edwards J.R."/>
                <person name="Puthanveettil S.V."/>
                <person name="Kohn A.B."/>
                <person name="Ha T."/>
                <person name="Heyland A."/>
                <person name="Knudsen B."/>
                <person name="Sahni A."/>
                <person name="Yu F."/>
                <person name="Liu L."/>
                <person name="Jezzini S."/>
                <person name="Lovell P."/>
                <person name="Iannucculli W."/>
                <person name="Chen M."/>
                <person name="Nguyen T."/>
                <person name="Sheng H."/>
                <person name="Shaw R."/>
                <person name="Kalachikov S."/>
                <person name="Panchin Y.V."/>
                <person name="Farmerie W."/>
                <person name="Russo J.J."/>
                <person name="Ju J."/>
                <person name="Kandel E.R."/>
            </authorList>
            <dbReference type="PubMed" id="17190607"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.09.052"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="19">CNS</tissue>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AF506759">
        <property type="protein sequence ID" value="AAN62847.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001191517.1">
        <property type="nucleotide sequence ID" value="NM_001204588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I6M6"/>
    <dbReference type="GeneID" id="100533285"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000070">
        <property type="entry name" value="Potassium channel, subfamily K, member 12 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005410">
        <property type="entry name" value="2pore_dom_K_chnl_THIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF10">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01588">
        <property type="entry name" value="THIKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="18">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="18">
        <location>
            <begin position="200"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="310"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AAN62847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="NP_001191517.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47870" checksum="3AD26E44E237FD70" modified="2003-03-01" version="1">MMSRPGRRGCCRIIHLKEDNARFLLLAIVMVFYMLSGAALFTALERDNEVEEKRIYDEIVKNFKEKYTMVNESDLQYLLDKHSEAETAGIVGNRRPRWDFSGAFYFVGTVVSTIGFGMTTPRTPAGKVVLIFYGFFGCAGAILFFNLFLERIITFLAYILRAIHERGQRKKGLMGRRRSSQGSEDEQLDSWKPSVYWVMLILLLGATVVAVIASGMYHPVEDWTYWEAMYFCFVAFSTIGFGDYVVSQQAEYPNVVLYRLGNFIFIVLGCCCIYSLFNVTSIVIKQMLNWMLRKLNCECRIRKPPMTRRNAITPGHLQRGGTMSTAGAAPAGSATGGGATKAPTVTVTDADGDSDSEYRRNSGEMISMKDFLQANKISLAMMQKQLWETSQRGSSFHNNNSGFQGGVGPLAILNRKLGQDEYDPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JA59</accession>
    <name>A0ABM0JA59_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101854608</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC101854608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005088959.2">
        <property type="nucleotide sequence ID" value="XM_005088902.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854608"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_005088959.2"/>
        </source>
    </evidence>
    <sequence length="384" mass="43601" checksum="8DB8F0D7D34040F5" modified="2025-10-08" version="1">MDLSYHLPPTFSRKPSNPILDGYTNHLMKEKLMGAKSSTANAASTETKKNKKISDVVTARDLEDRSRSLVQKTGKSLTCLLGEAMKLNPDRHEMEWCSNLITLWNSYIRCTKNPGHFNFIPVYQFGLGHLPASCRDRRMVAYIRALSRFTVRILTRHTSIHRPSYFPCGNMRGTDKLRLATGFAWIPGKITDMPCPIENCPYNRRSHRVYGHIRIMTNKHVVYDQFEAAQTRAQFFYDNANNSRGLPVVQCISLDYSIMDSDMAYLNCITHDSNLCAILQEEMEELKTTYNSIPLDIWQSCEDLSVVISHPHGMAKTVSVGSHHSFDVTPTRAHAHYYSSATCPGSSGAPVFYVSRREKGAHPMWIPAIHSFHCNILQMNCGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JAB0</accession>
    <name>A0ABM0JAB0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TM2 domain-containing protein CG11103</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101860213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005089072.1">
        <property type="nucleotide sequence ID" value="XM_005089015.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860213"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF4">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045392285" evidence="9">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="10">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005089072.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21126" checksum="E6A0D5C93FEFBE85" modified="2025-10-08" version="1">MMRHLVVLYFTGLSVLIVLSFCEEDRYLMDESTGYTYDPKTPLVMCSYLPLEFLNCSAPEDLKGNATKRSEQGYGCSKWGGEKYEDVQNTSVWCTALPGIECYGNRTFLRDGFPCIMYNNHYFVTTLIYSVLLGFLGMDRFCLGHTGTAVGKLLTLGGLGIWWIIDVVLLVTGQLKPADKSNWVPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JC76</accession>
    <name>A0ABM0JC76_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">GTP-binding protein GEM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC101859532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005090339.1">
        <property type="nucleotide sequence ID" value="XM_005090282.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005090340.1">
        <property type="nucleotide sequence ID" value="XM_005090283.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035826936.1">
        <property type="nucleotide sequence ID" value="XM_035971043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101859532"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005090339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005090340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035826936.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="52669" checksum="E674D8307328D5DA" modified="2025-10-08" version="1">MTQDTAVNSPSVHGRGHSGGAQPPPRSPRHPQVRLRRSRMDSNDSEHSSGSGVSQDSGHLNPAPAIHLIPGSAPASRASSFREGQRPPTSRRSPSRKSGGSGGGSSNSNISSSNNAANSSSSSSSNNNKHHVAKNASSDETNGESLGPRRSSMPNVTENFLTVPHPDDAKDNRLRRVRSFKTTSKGGVVNRGDSFKKKSTHSLMSTGSAVTDLRQQQQQQQLQQQQQQQQLQQQEQRQLLANMVNNNLFTPEAPPVPTYYRVIMMGAAGTGKSQMAKQFMTSDFVGGTEDSSDAHENTVTVLLDGEESTIEFIDPLDRNVIDEGLCQLLDAYVVVFSINDHSSFDQAQELVRYLRVEMGTDRVIVLVANKIDLVRKRKVTADEARLVAETYDCKYTETSAALNHYVDELLVGILTQIRLHMRIPFTTISFPGKEQRNEDGDRKEKPRSPMKGPRGFFAKLFRRSGRKKLKPCENLYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDJ8</accession>
    <name>A0ABM0JDJ8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ER membrane protein complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101858158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091223.3">
        <property type="nucleotide sequence ID" value="XM_005091166.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858158"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046135668" evidence="8">
        <location>
            <begin position="39"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="9">
        <location>
            <begin position="61"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005091223.3"/>
        </source>
    </evidence>
    <sequence length="243" mass="27479" checksum="FA6D5E167BAC91A1" modified="2025-10-08" version="1">MSKNKGESFPALKMEEPMQVFQFLLCLFLFNWQSFGSAVEIDEIGDRSEFKIEGKVFVASKDKEWTMNSRVLVDGGEYLGFVRTDGTFVVNGVPSGSYIVEIANPNALFEALRVDITSKGKMRARRVNFLQPNLVKTVSYPLEFRERGKPVYFQKREQWRLTDFLFNPMVLTMIVPLLLIMVLPKLMNAADADTQKEMQTQMNALNNRPNMPDPAELLSNFFSGGAAAKKAVKAKPSSSSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JDT5</accession>
    <name>A0ABM0JDT5_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division protein kinase 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101853437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091390.1">
        <property type="nucleotide sequence ID" value="XM_005091333.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101853437"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07839">
        <property type="entry name" value="STKc_CDK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005091390.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33563" checksum="CEB60EFD4FBDB5FC" modified="2025-10-08" version="1">MQKYEKLEKIGEGTYGTVFKAKNRDTLEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNVVRLHDVVHSERKLTLVFEYCDQDLKKYFDACNGEIDPDTVKSFMCQLLRGIAFCHSNNVLHRDLKPQNLLINKNGELKLADFGLARAFGFPVRFYSAEVVTLWYRPPDVLFGAKMYSTSIDMWSAGCIFAELANAGRPLFPGNDDDDQLKRIFKLLGTPTEDTWPGLSQLPNYRPFPVYHVSTTWQQVAPKLNSKGRDLLQKLLVCYPPDRLSAEDSLQHAYFSDVNPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE31</accession>
    <name>A0ABM0JE31_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L50, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101855702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091575.1">
        <property type="nucleotide sequence ID" value="XM_005091518.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101855702"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542">
        <property type="entry name" value="39A RIBOSOMAL PROTEIN L50, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005091575.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31061" checksum="723B6716E7BB5E6A" modified="2025-10-08" version="1">MATTMNKAVLGLRATGIFQGRSNKCLTWSIAQRSASWTKFFRGSKSKDDDEDKEVLEVKPRKVSLADGPTTAARLGSLEKKIGVVSVRGYSPPQEVEGKILSTAKSLVGSDVSTDFRLDDRMLRFKLLTSLMQEFDHSIPNTELTAMSTLSDVITFFSTPVRDRSSYEDMSTLNLPKNLHIQLEPLRFSADSDTFFDGKTAFPDRPTVVSSLKYSRKFKGNEGESRNQPSLTNFEKEKMLQEDREIRRRDILPSEGRKRRPNTHRQIETEVPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE87</accession>
    <name>A0ABM0JE87_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC101864200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101864200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091691.1">
        <property type="nucleotide sequence ID" value="XM_005091634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101864200"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005091691.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="32281" checksum="F586D492F2848B1A" modified="2025-10-08" version="1">MNAMSVKRKGGSLSFPKSASTRQDTNTLKSKQLALKRRFSKLRKRFPDLEPRLLENLLCYALTLVVPGTEELLDTKIFMAEMNLSFGFTNSDFILRIYNMTRGKHEYVTVDDYMLLLTIFYSNDLNRKAEYTFDVYDVDSDNIISTAEFARYLRGGMPISDPDDREANEETLREVMDILTNVMGINDKGYIHKDHYMKVVRDKPEILEFLGQTLPSVYVQRHFTETYISPQRFSPDQVSRYLRSRRHYILQEPKEQKPKQLLGLYPIEIIYPRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JE91</accession>
    <name>A0ABM0JE91_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FMRFamide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101847795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005091705.1">
        <property type="nucleotide sequence ID" value="XM_005091648.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101847795"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="72"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005091705.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40025" checksum="EC34BCA460A100BE" modified="2025-10-08" version="1">MSPSFGLLDLPDSVGGDVMMNTTSTTQQTTLTSAAAAADDDLSDLTNLVMETIELVINCFLIHIIAGIGSACNIITVIVLVKTRGSDSNTTILLSLALCDLAFLLTLTVRKMDCIIARFDPVAGLNHQAYMTAYVIVTSRLVMFISSGHIIVIAVERFVAVIFPFKAKILFSRRRVMIMLLSLYVVMAATATPYLGYSGVVWSFNPAFNTTVSSVQFARYYLEMYEGLTNFNILVMGILRGPVSFTAVIACCAVIVHRLRQVSKQRETMSSSSSQQQVNVKVTRMLLALCAVYVITNLATVSLAVYTFVTSSNLLGPTLYFMVNMEEMLFALNSSANFFIYIFMSSKFYKTCRSLFCVSAQPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JEM7</accession>
    <name>A0ABM0JEM7_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BLOC-1-related complex subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101853063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005091995.1">
        <property type="nucleotide sequence ID" value="XM_005091938.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853063"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019314">
        <property type="entry name" value="BORCS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046465">
        <property type="entry name" value="BORCS6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13440">
        <property type="entry name" value="BLOC-1 RELATED COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13440:SF7">
        <property type="entry name" value="BLOC-1 RELATED COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10157">
        <property type="entry name" value="BORCS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLOC-1-related complex subunit 6 C-terminal helix" evidence="2">
        <location>
            <begin position="340"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005091995.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="47856" checksum="D6833E851B9F97B1" modified="2025-10-08" version="1">MSVVEEKTGSVSSSCNSMKETPAFPTSGKSSANVKADCNDLANSNHVSGGTRDSDLCPNGQHDDMSEQDILSPDISLSSQTTLRYSDVEPELKEHDKSHESSDSIETLEDLPAEDSHIEINQKFLQHLTLTQNVSGSSLDSFGKTSSSEQAPNISSLSDDNASSDSHEVIPEFSSIPRPESLSLPRPLQTIDRDRVRSRSENSNSSQKSTSSHNKLSDDPSCSEAAASSSMDKSAPLEERGAHFIEDPGVSFMEPSGLSQGLPQGTITRRGDMIQFVADDLTEKIKLSSPKSQADSESLGSRRSSVRSIVSASSSTSAATSSGISRSPSSQWQQSPDDIPPIDVAAVAELEGRARRVADSLDLMMGNIRNNLHKMSAITIGCQEAYKRSVDITCDSVDGSIKAMYALMAKCEELSTSMKPVEQLAGQIKEIKRILELFESQLGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JES8</accession>
    <name>A0ABM0JES8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC101852828</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101852828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005092081.1">
        <property type="nucleotide sequence ID" value="XM_005092024.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101852828"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005092081.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="20838" checksum="997A3F99C6924815" modified="2025-10-08" version="1">MGTGNESQAAPSQADLKGIVDDDVLNVFVVIFYVTATGTISFSGIIFNIINIIVFLKQGLKDTVNITLFGLAISDTGSLMGLLWMSICFNPALVNSGIPFDHEDIQYLTAGWPHVIFARITSWITAFVTFERCLCIALPLKVKTIITPRRAVIVVVSIYLIMIACIAPVFYSVSLGPKYFPLKNKTLIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JG06</accession>
    <name>A0ABM0JG06_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ homolog subfamily C member 13 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101847707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005092835.1">
        <property type="nucleotide sequence ID" value="XM_005092778.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847707"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045802">
        <property type="entry name" value="GRV2/DNAJC13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19432">
        <property type="entry name" value="RME-8_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005092835.1"/>
        </source>
    </evidence>
    <sequence length="2252" mass="255807" checksum="4F5E29D7B1E615A8" modified="2025-10-08" version="1">MNGARNMGTLKDNKDVACYFITKHSWKGKYKRIFSVGTHGITTYNPGTFEITNQWAYNEFIGIVPNIKAPNTQEFVISMKKGAKKTDSMKFSTDHRADLLTEALRFRDQFADPSNHRAKRFNCFKAHWSENRVPVILEVNQGSLDQLDPSTNRKLCSYDYKDIEGLTLVSDYPGGVAIIHGGFSRLHLFALEQREELCKAITEAGAAFVGVTIRIRKEPISFDQFQTHRLGKYSTDEAVTSYAEFTVQKVSVRHTDTVRRTLCLTETCLVERDPATYNICTCKPLCDVFAINRSAGNPQEFSVEYVKGAIRTYLSTDRDALIASVLDGVRASGNRDVCVKMHKTPRGYRLGPFTVPVDEEVEATHLKSLHTVPAGMTFDQAVFRFNANVSYNGLLHAVTAEGLFAQNKEKLINLALSSLIEREGDQDKVSNECLEAQFHALRRLVASKAGYQGFTEIPRMREKVGLKVVKALKRNSDAITHAALDMLCALMQPMHDNYDLRQEQLNKTSLMSSRKFLETLLEMFNEHVVHSTGALVIAAMLDFLTYALCAPYSETTDGTQFDQLLEMVAANGRVVFKLFQHPSMAIVKGAGLVMKAIIEEGDAEIAAKMQDLSLSEGALPKHLHTAMFTQSIDSRMLTNRQLSRHLVGLWVTGHPTAMGLLKRILPSGLLTYLDSADDVPMSETDRLHIRDNVKLAQDHFNKNKRNQQLLMLEKKIDNLLQHWRSRVGLDKSKQQQNEKPIVLRKRRQRVKSEANWPLFYYQFNQDHAKPNLIWNYKTREELRESLENEMRAFNVDKELGATFIVGWNHTEFEVPYHCLADEIKIGDYYLRLLLEEDDDEATEETSAIKKSYEFFNDLYHRFLLTPKVNMKCMCLQAMAIVYGRCHEEIGAFNDTRYMVGMLERCTDRLERDRLIIFLNRLILHQRNVKEIMDANGVKTLVDLLTLAHLHTTRAVVPLQTNVIEASPDMQRDSEKEWYFGNKEKERLGPFSFEEMKAFYEEGTLHAKTRCWAQGMDGWRPMQLVPQLKWTLLATGQAAMNETDMATLILNMLIRMAEYYPSRDTDGAIIRPLPKIKRILSDATCLPHIVQLLLTFDPVLVEKVASLLFLVMQDNPSVSRLYLSGVFFFIMMYTGSNVLPVARFLKNTHIKQAFRSEENTTSDVLARSVLGPILPEAMVCYLENYSPDKFAQIFLGEFDTPEAIWNSEMRRMMIEKIAAHLADFSPRLQSNTRALYQYCPIPAISFPQLDNELFCNIYYLKHLCDTARFPDWPIKDPIRLLKDILDAWKKEVEKKPPTMSFEEAYSVLNLSKGTGGHDEGKIRKAYFKMARDYHPDKNPEGREMFEKVNTAYEFLCSKSKVKEGPDPQNIVLILKAQSILFSRYKEELQPYKYAGYPMLIKTIRMETNDDQLFSKSAPLLSAASELAYHTVNCSALNAEELRRENGIQVLQDAFSRCVNVLSQSSKQEETAVHVCTHIARCYAVAAQFEGCREKIQENSAIIKDLCRILYYKNLPKLCSVVCECISAFCVDFWLQTNLFQSGVLWHLLLYLFNYDFTLEESGVEKSQESNQQEVANHLAKMSVTACGRLAGFFSSESELSTPDNPSVKKSLYSLLTPYLARKLSNESPVECGTGGRNEWLLKVLNSNSENPYLIWDNATRAQLCEYLADQQQRMIKTGECDPSYGSDFVFEIHAKELIVGEIFVRIFNEQPTFPMENPKGFTIDLLDFLGSQAQYLHSLMMLQQQQKANPSPDHVERLGKVEMALEALRNIIKASPGVEIQCIGHFKLIFALLRMEEFSKLQQFTLEVINCVTGNQECVKDIAAAEVLGYLLFSLQSVPACRILTLESLFSLMSNTQIVKEAMVKGCLVYLLDLFCNSTNPTVREKTAELFSKMLSDKLVGPKVRIVLNKFLPPIFMDAMRDSAEAAVHMFEGTHENPELIWNDDAREKVCGSVKKLRAKHFQAQREDANVKWSMKEDFEIVYSDVQGEVVVGGVFLRLFISNPAWVLRRPKEFLTELLEKWTQITGSSTPDNEMLETVTMAVVCLFQAHSSLLDQVPSLGYVPRVFSAMTSKLTAVPKAGIQVAHQLSYNELCIRSMSTIECIKPMQVAMKERRDMIGLAAEALSKMFDKCDEDLIQQALSAQLIPYLLKLLEGGLEAMENPAATKAQIVKALKSMQRSLVHGEKVTEILDKSAVWKDYKDQRHDLFITDTNIAGYLTGPTGPSVAGYLTAGTMRSAMPDAPPPIDHHEDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGB6</accession>
    <name>A0ABM0JGB6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTPase IMAP family member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101860149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093064.1">
        <property type="nucleotide sequence ID" value="XM_005093007.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101860149"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF184">
        <property type="entry name" value="GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005093064.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41539" checksum="2FD9928EDDB29855" modified="2025-10-08" version="1">MYRPGDVPNWRYASSIVDYNLFLIGKTGHGKSSTGNTILGKEAFGVSDNAESATINVQVATARRGGRHFRVVDSPGLADTRLSSAAAISKACEDTRTGILQCPEGVDAFLLVLKYGNRFTQEEQETLASLRSILDPNVIRDFCVVVFTYGESFDMKKKKTGVSFPEWCQQQTGALSTVLEECEYRCVLFYNLDPDKMAAPMEELLRHIATIRQESGCYTLTMFSDMDFSHRQLIAVANAPQLCQKYDAETLALRQKLDMITFTSDRWKLCGLISELCSLKSEVQAVKLQASLDECGTGVLLYQKLALCALEGDVTSKQRSMESRKEAEERRVESEQENLRQETERLRLATQRLEEQRREKEEEGECVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGV1</accession>
    <name>A0ABM0JGV1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein LLP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101850066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the learning-associated protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093369.1">
        <property type="nucleotide sequence ID" value="XM_005093312.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101850066"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018784">
        <property type="entry name" value="LLPH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253:SF1">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10169">
        <property type="entry name" value="LLPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005093369.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13893" checksum="2367397F5D6D8F58" modified="2025-10-08" version="1">MAKSIRSKHRRQMRNVKREHFAKKDLDRLKRLASKAKELDLDNVVTMKSAEEIKDKPSTSTSDTGMEVDNTKKVFKKKTQQNEDGHYPQWMNQRAVKKQKVKVAKLKTKKKIGKKIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JGW1</accession>
    <name>A0ABM0JGW1_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC101858252</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005093402.1">
        <property type="nucleotide sequence ID" value="XM_005093345.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858252"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0187">Copper transport</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="802"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1221"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1251"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="14">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="14">
        <location>
            <begin position="147"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="14">
        <location>
            <begin position="244"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="14">
        <location>
            <begin position="351"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="14">
        <location>
            <begin position="427"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005093402.1"/>
        </source>
    </evidence>
    <sequence length="1358" mass="145297" checksum="BAFB5E7F79682C0A" modified="2025-10-08" version="1">MNKRKGYQKLKVSIETHEADIQYSPLQTNPQILAEAVTSGDAPVMVKDIQEAAPLIEGGDAKEESVEVLVAVEGMTCMSCVRNIEGNVSKQAGVKSISVSLEKKLARLLIDVSKISPADAAEAIDDMGFDATLISPLTPSTPQTNNARTRISVEGMTCQSCVRNIEGNIATKPGIVSITVSLTDKEALVTFNPSLTDPEAIAEQIDDMGFDAAVAADNGGEPSVGSFVNLIGVNGSSSVPKSTQTAVVNIYGMTCNSCVKNIEGNIGPKPGVKEIRVSLADQNGVIEYFPDTVTPAQLVEMIDDMGFDASLSTASAKPSPSKSTKVKVHLARSISDNELVSPVAADTDDVAKCHINISGMTCASCVATIEKNMMKLEGIKNVLVSLMAQRAEVTFDPAYILPSQIANKIEELGFAASVAEGESLGKGLVELTISGMTCSSCVNHIESHLKRKPGILSASVALATSTGKFTFDSEATGVRDIIEAIKDLGFDAHLKSDDNEKASRYDHRDDIKRWRTSFLWSLIFGLPSMIAMIYFMFGVSGDGGHAGMNHTNSSGPKKGGSHIHYHQIMVMPGLDVLNLIMFLLATPVQFVGGRYFYSQAFKAMKHGATNMDVLVVMATSISYIYSTAVVVAAMAMREDFSPVTFFETTPMLMVFISLGRWLEHIAKGKTSEALAKLISLQPSEAVLVDVDKKFQIQSERVINLDLVQRGDVLKVVPGGKIPVDAKVVFGHSSCDESLITGESMPVPKNVGSSVIGGSINQNGMLLVEATYVGADTTLSQIVKLVEEAQTSKAPIQNLADKIAGYFVPVVSLLSLTTLVTWVIVGYSDVTLLDSDFDPTGPTPASEIIFQKAFQYAITVLSIACPCALGLATPTAVMVGTGVGAVNGILIKGGEPLELTHKLQTVVFDKTGTVTHGVPRVSRVSMFVRDSTCSFIKFLAIAGTAETSSEHPIASAILKYVKETLGAESMGKVSEFSAVPGCGIKCKVSHIEGLLSRTDSNAVNSRKNRAGSQTIRTDNLVYGEQDSGTNFDMPIGAAASESYEVLIGNREWMNRNGLIVTNTMDDVMTEHEMQGHTAVLCAVDGNVVGMLAVADTVKSEAHLAVHELRKMGLEVILLTGDNQKTARAIAKQVGISKVFAEVLPSHKVKKIKHLQAMGLKVAMVGDGVNDSPALAQADVGIAIGTGTDVAVEAADIVLIKNDLLDVYAAIKLSKKTVRRIQLNFLSACIYNILGIPIAAGVFTPLGISLRPWMASAAMAMSSVSVVSASLLLRTFRKPKKEDLLTQEYYNRYYQDQDTDDISMHRGDDWETSRPTARAHSGNSRWSWLKVTSTSHPPTPDQRSLLDNVDEAEIEMTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JHL4</accession>
    <name>A0ABM0JHL4_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import receptor subunit TOM22 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC101854702</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005093830.1">
        <property type="nucleotide sequence ID" value="XM_005093773.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005093831.1">
        <property type="nucleotide sequence ID" value="XM_005093774.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035824486.1">
        <property type="nucleotide sequence ID" value="XM_035968593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101854702"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12 15 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_005093830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_005093831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035824486.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17665" checksum="67F13B8ECC4D637F" modified="2025-10-08" version="1">MARSTCSSLAEKPFCPPSPMSGHEPSSRHCKKKMAKDPRRAIDDDDLDEDESLAERLMGLSEMFPQSVRKTCSTAGVCLVSLTKGGYWLMRNALWIVSSSAVILALPVIFESERAQQHEEQLQQQRQILLGPNAAVSGSAASNNLLPGMGMMPPPPGAAARKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JI72</accession>
    <name>A0ABM0JI72_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18">High-affinity choline transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC101859391</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094203.1">
        <property type="nucleotide sequence ID" value="XM_005094146.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005094204.1">
        <property type="nucleotide sequence ID" value="XM_005094147.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101859391"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005094203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005094204.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="61740" checksum="A1D3B48108729627" modified="2025-10-08" version="1">MAIHIPGLIAIVVFYLLIVAVGIWASRKSKQTGSTADSEDVMLAGRNIGLLIGIFTMTATWVGGAYINGTAEVIVSSGLLWCQAPVGYALSLVFGGLFFANRMRSEGYVTMLDPFQHKYGERMGGLLFVPALLGEVFWTGAVLAALGATLSVIVEMEPKPAIIISACVALFYTLIGGLYSVAYTDIAQLFCIFFGLWISVPFALTHEAVSGITANATQNWILPIDTADMPMYVDSFLLLTFGGIPWGVYFQRVLSSKTALKAQILSYIAAVGCIIMATPAAILGAVAASTDWNQTNWPGKVPIPAEDLPMILPMTLQYLCPPAITFIGLGALSAAVMSSADSSILSAASMFARNVYRSLFRSVASEREVLWVMRVAIFGVTALALVMALCVESIYALWILCADLVYVILFPQLACVIYIESSNTYGSLAGYVMGLFFRVAGGEPAIGLPALIQYPGYNSKTYAQPFPFKTLSMAITLSSLIGMSYLTKYLFESGILPRRFDIFQCIVNIPDEQMVLASRDSVDERTKFGLYGKENGGKVNPALKFSNEDLITTGELESDSETATSEKRGSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIL0</accession>
    <name>A0ABM0JIL0_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methionine synthase reductase</fullName>
            <ecNumber evidence="11">1.16.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC101858848</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.16.1.8" evidence="11"/>
    <dbReference type="RefSeq" id="XP_005094471.1">
        <property type="nucleotide sequence ID" value="XM_005094414.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858848"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06203">
        <property type="entry name" value="methionine_synthase_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="17"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="360"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_005094471.1"/>
        </source>
    </evidence>
    <sequence length="785" mass="86810" checksum="8B1B41D620B815FF" modified="2025-10-08" version="1">MSPANMSGGNTLQKNRFLVLYGSATGQAQAMAEEICEKATGFGLTAELHPMDEIGKRFNLEHEQCVVMVASTTGDGDPPPNAEKFMRRIKKRTLPTDYLAHLHYALLGLGDTNYSSFCRCAKDLDNRLLALGARQFFATGFADDGVGLEIVAEPWLEGIYPALQKFLGVTEGTGGSLTEKVEAPAQSSPASVDISEARDSTKQDNVEVVLTNSGVRESQIESQSDTIEAFKSVTCDEISVKETRASEGNGDGSVQVKNSQDCSVNGCDAELTVEVQSKILGQKTFFDSQRKCETPCQLVDFAAASDAPCALVSSDSELAEKSLTVPVLPPAYLEASFSGDPVNLRELSFQNDYKLPSAVSPVIKVQVSAARVLTHPQAVKKTLLLSLNLQGAGVNYRPGDSISVICPNNCSEVDMLLERLGISNKADDCMTLNIIPNTKKRRAAVPSFMHEVSTLRHTLTTCLNIREPPSKAFIRALVEHTTNPKEARRMQELCSKEGAQTYTRVVREKCISLLDFLHAFPSCKPPVERVLEHLPRLQPRPYSACSCALTDKDKLDIVFNIVEIPMSCDDGHAYSRRGVCTGWLDDITRSMQDKGLEDEELTVEIPIFLRSNQHFQPPDDLSRPLILIGPGTGVAPFIGFLEERRHQLKLQPEGSTYGETWLFYGCRHQKKDFLFRDELHQFEADGTLSRLCVTFSRDDPPAGSTEPCLRYVQDFLRQTSQDIARLVVDEEALVYLCGDAKAMAKDVTAAFEDILQKEKGFSKEDANMYIMKKRIHKTFLEDVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JIZ4</accession>
    <name>A0ABM0JIZ4_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Neuronal acetylcholine receptor subunit beta-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC101863970</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005094753.2">
        <property type="nucleotide sequence ID" value="XM_005094696.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863970"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="42"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="257"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_005094753.2"/>
        </source>
    </evidence>
    <sequence length="509" mass="58679" checksum="4B1CC7822B17452F" modified="2025-10-08" version="1">MVEMHLPSPVSLCLLLGTISFLWQSSQAKPRRRGMSYEDMVVNKVVESYKMRTVHSRPVLNYNDTLSVAFAIQLQQIMGLDEQNQVLTLNIWDQMAWDDHQIKWDEEEYGGVKDVRVPCHKIWTPDIKLYNYADLRLEEHRDALCVISSDGGVYHVPQVVYRSSCDIDVYVFPFDVQNCTLKFGSWAFMGNELDLKFFEDKNFIDMTQYLDSASWFIIDCPAFRHVINYTCCPDNTFVNLQYHLIFQRRSALYNYILILPCILLTSITLILFWIPPESPAKTQLGLAIFIAFFVLLKLLEKNLPPGTRHMPLLGTYYCLNMILITLSSFLNVLIVDLTTHGLRTATPPRVGKFFFTYLAKCLLMEDLVRPFVNRRVKTRTPKGGDLGNLEENKWKHDPTASNEALAQLQRDQTMQQGGGGPLAEIESKLNELREFMKLQQQRLKERDQKEIVAKQWKAVALILDRIFFIIYLCIITASLCYTLPVLTSVRSHYNSTLLDKARGINTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJ05</accession>
    <name>A0ABM0JJ05_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC101847093</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC101847093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005094766.1">
        <property type="nucleotide sequence ID" value="XM_005094709.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847093"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045389122" evidence="2">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_005094766.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="45837" checksum="66E01D9F7C867091" modified="2025-10-08" version="1">MSGLWKYFILGALVLTVAMGQDAAANETSSAADSDTPADDSSVVAEALSPDTNNTASVDGNGAGGQDPPASTELKEVECKLDEDLTGEWMSTVWGDVSFTDQSLVAEIDPVEGKSNEFECHKKFENGDIIFRSTVFVQDEVEFVYYTCVNFQKRNENNFFARVKTPRNPKVNQLPMEKRPITKTNNTHIRYCKTSPVEGFLLKKGKVQDGALGCPDTIKGIFNVTYKGVTQRKCPDGALLTTCEAPKALSVVHSDCGDNSTTYPESDDFICIGGGLYEVTLFRNSTELNPFTPFSCMTLSVDENDNATVEVTQKGDGCGEKWVKPEGNVHAEEFTLVKTDDCLPDEVIPPEVVDIFEPNSTRTDDTPSDSNETSSGNETSGGQGSGTEPGGDPDDAGSFLVSNGFVVTFLVASLAILLSQHNDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JJW6</accession>
    <name>A0ABM0JJW6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rhodopsin, GQ-coupled-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101848191</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005095383.1">
        <property type="nucleotide sequence ID" value="XM_005095326.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101848191"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="54"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005095383.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21509" checksum="0490AD2A1CD766A7" modified="2025-10-08" version="1">MKSSSYHERDIPVVTTVLSMGDDKDIDYKEGVTHEEYLVIAWVLTLVAVVGTVCNALAVTVFYRFRELRSPTNSFIIALCVCDFFMSCIGTPIPAFYAFREAHITSRAVCILDGFIIYFLACTSIYLLAAISADRYIVIVKPFETYTVTQRAANVAIAICLLLGFLMALMPVSGWNEYTQEGIGTWIVRGSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JM99</accession>
    <name>A0ABM0JM99_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 544</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101854494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005097013.1">
        <property type="nucleotide sequence ID" value="XM_005096956.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101854494"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005097013.1"/>
        </source>
    </evidence>
    <sequence length="627" mass="69718" checksum="B1D5FB4B84FFA9A2" modified="2025-10-08" version="1">MAGNFSVAFVANCVCRDFGTQTFITFEDMNLLITGMVPEKISMGEKSGQERHNKNIFYHQATDDSGMDPTTPDNTAVARTITKSSRSDTEIGLPESQLIIEQSDIKAKHRSAVVSDQEILKNGHCSNYSPKMSDETTTSLIIPCNDEYGLTKAENDGFRNSVNSPLSNFRSLSEKVQSSDRTKGMTILKRKTKPSDTSNIDANVKDGSQTRPLSTCQYCSKKFSKKYLRVHMWIHEKEKQFSCDLCKKKFLRARELISHKRTHTGERPYSCAVCSQKFVSASSLRRHELLHNRESDESRQLVSSYGCDICGKVFAQKGNLNVHLKTHSGIKEHACTQCSRSFVSSGDLKRHLRVHSKEKPFTCIECGKSFTASSSLVCHMRVHTGERPYICSECGASFSVLSHLKQHNKIHERGDLWPRKKKTFQTRDKSLTKKTQKDDSRNVQSESSARSSQLDVCQGLSSLTNRLDQSENTNCLYQHHSQDGLLFSGPDSVTNYFKSSSLSNSQVVNFTDPNAVCSSGDTIAVVIQNSLEAHTGLIDKNFVDQQPNTDTDDDIGGHIVSLSSSTLCHADVNRHTEMSFSSFGVDEIQILSYSGGSLNADDVSRVTCAPVEGSIPEYIPDVSSQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JMF6</accession>
    <name>A0ABM0JMF6_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101861119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097128.1">
        <property type="nucleotide sequence ID" value="XM_005097071.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861119"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="408"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005097128.1"/>
        </source>
    </evidence>
    <sequence length="631" mass="69561" checksum="CD08228B9B23EB1C" modified="2025-10-08" version="1">MAENGTPAEEYHPQRTPSPRGQSPPTATTSACTINKKLLPVKSYYFMIMSAVGDLLPFIALHMRALGLSPKETGIIYGVMPFVGFFMRPIIGAVADKLKKHKAVLILATIFTGVFYFLLLFVPFRPAVPSVSISTTLHCNSQDSFLHDCDDGRSQDSCQAGLNFLNSSISDRENESISCSLWCRTGADLSKSLFTACFNDTGPHNGSRRCSEKLTFSSHLNFTVNDIHSLVAPDRYLNGSDSCRDYDLRNISSINNSTHEGRRILCDREMSFECEVTCSETFQCNQKRASFDRTFIAIFFIFLMANIVFAPIFPIMDAAAYDILGEEKRHLWGKQRAWGTLGFAIWAVSATFILHMQGDQDSEYSVLFYLFLPLCVLSAIVAGFLEMSSDIICGQFLKNVRNLLSHAEVLAFLTVVMFFGMLLGGLEAFLFWYLLSLGSPKLVFGFILVVNCCSELPMLWVAGMIIEKIGLVSCLYLALLCYAVRLLVYSVLSNPWLVLLVEPTHGVTVALMYAAASSYASIIAPPGMSATIQGLLAGLQFGFGKGIGSLITGYMFENIGPRWTWRTFSITCVVLLVIYVILNLFVFKSHSPAGRGSAEGDEPATEQARQEETLMNNSAPSAVEGVQDTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JND3</accession>
    <name>A0ABM0JND3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAP kinase-interacting serine/threonine-protein kinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101862871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005097740.1">
        <property type="nucleotide sequence ID" value="XM_005097683.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101862871"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="99"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005097740.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="62425" checksum="71926F7DCD73EFC4" modified="2025-10-08" version="1">MRTTVFRQVKRKRGRIQDAEPYCDDKSSILKTNEVCNDGVLRTPYTSTTSNDGVFRTSISRRECDNNNGGTFDSSSSKLKRNHRQVKQTTFASFCERYELTGEKLGSGSFGSVYTSRDRESGTEYAVKIIRKCHDNTRKKVLKEIDICQRYNNCESIINLVEFGEIGDAFFLVFDKIEGGDLSQMLESRKRLSETEAARVISTIAHVLLTLHNDGVAHRDIKPDNILCQKKGEVTSLVLCDFGLASDPSFRRDSKGDIMKTTLTSPVGTPDYIAPEIVALMCNESKAPYDTSCDMWSLGVMLYKMLFGVMPFHRGCEEHRCFTDLSCEDCEIISYQDILRGDYRFPEKAGELCSDSALDLIQHLLVVDPQARYSAAEVLQHSFLTTSVSSDLAMSASVCGQVEKIVGQFQDSGPNFKSSIDNAFSTLKTVSAFNDAVLLSSDTYVTSNDGVFCTSISPRTCDSNGTFDSRSSKLKGMDRLGKQKTFTNICESYESLGQKLGSKSHEPVYANQDRDSETEFAVKIKNCDERNVSKKINLCQRYICENIFSLVEFHEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JNY6</accession>
    <name>A0ABM0JNY6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TIMELESS-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC101850168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098114.1">
        <property type="nucleotide sequence ID" value="XM_005098057.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012937827.1">
        <property type="nucleotide sequence ID" value="XM_013082373.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101850168"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="8">
        <location>
            <begin position="81"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_005098114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012937827.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42080" checksum="854FB575A7EE06FA" modified="2025-10-08" version="1">MDSIPLEMDDIFDEDGQDFNPARLPDLEDELEPMRNMMHASDNDEGDEDGEQPATDDPELLAKLKSMKGASKLTAKRTMPKLDETRLTGERGIPVLPKVFQDIHLKGKNHEVEDLKAIVRRLEHWGHRLFPKMPFAEVLERVERLGAKKAVQTCVKKIRLDMLEMPEDREDEDDVQRAGDTQQEVQVDEDEIEDLLREQETYDRQHGHSDDDDPFHTTFQTEQSAKSESNEQEKTVISDDVKARIERNKQLAMERRAARLAKTTDGTSITTGVVSDHSSSSGTQPQQNGQLSLNEEPSNMDLVVGDTSSKKAEKVDEQDNSLCDNDVDNLEREHSERVQDTSETELQSEGRELEKQTDQSVQDENDSIAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JPV2</accession>
    <name>A0ABM0JPV2_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC101852022</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101852022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005098724.2">
        <property type="nucleotide sequence ID" value="XM_005098667.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101852022"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005098724.2"/>
        </source>
    </evidence>
    <sequence length="119" mass="12095" checksum="E13C5B2F7AFA1C04" modified="2025-10-08" version="1">MATQPWISERGPRSPRKSYKNESLLLNNGLEGFYQANAAAAHAIATQRGNHPGHVNQGPTTVVASSRAVNGYDTSAQEDMDTSGGAAAAATASTSGGGVTSSQGGATGGVHHRRSCTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ17</accession>
    <name>A0ABM0JQ17_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Immune-associated nucleotide-binding protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101844996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005098866.2">
        <property type="nucleotide sequence ID" value="XM_005098809.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101844996"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF184">
        <property type="entry name" value="GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="7"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005098866.2"/>
        </source>
    </evidence>
    <sequence length="296" mass="33813" checksum="89EE65EC451E63E3" modified="2025-10-08" version="1">MSASVNSWPPTMMLLGKVGHGKTATASSVLERRISYNVDEETTVVFFSGRATSADGVSKVDVIDSPGLFNTFPVDDAQDTTRMFEQIEKAIGINDDGINAFVIVFRFGTRYTDDEQKVVRNLEQAFGPSFPRFFADHVIIVFTYGSDYRLKHGSAPFEGWVLSQMADMKKLFKMCQGRCLLFDNVTCSPETATEQREKLLDAVSRMTRKFTIEDYEKTMPHRMKLLSELTVSNKWPKVRRILQTIFRLCRSPFILLPLSVFIFISYFYFPYSYFYKPSEADVSIENVVYASPKNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JQ98</accession>
    <name>A0ABM0JQ98_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CXXC motif containing zinc binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101859331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005099014.1">
        <property type="nucleotide sequence ID" value="XM_005098957.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101859331"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005099014.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17982" checksum="9A544FC62DF1967E" modified="2025-10-08" version="1">MKTGLQISAQLENIGSFKASGDDFRWYLKLSCSSCGEETSDYVYCTLRETSPLTGGRGQASLVLKCKLCKRENSIDIVTESLSPYTEEDSGKFKTIVAFDCRGVQPIDFSPRVGWEAVGLESQTLFSDIDLNEAEWFDYDEKAGESVSITELKHQFVPVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JS03</accession>
    <name>A0ABM0JS03_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vang-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101858278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Vang family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005100189.1">
        <property type="nucleotide sequence ID" value="XM_005100132.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101858278"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009539">
        <property type="entry name" value="VANGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20886">
        <property type="entry name" value="VANG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06638">
        <property type="entry name" value="Strabismus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007991">
        <property type="entry name" value="Strabismus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005100189.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="63243" checksum="54A599E28944334F" modified="2025-10-08" version="1">MDGGESVRSGRSERSERSHRSHGSNHHGGGGHHRQHGRQQVPSRQGSSRGMARGHDMDRDDRSVTIKTPGQEPEMDRGMEERIEVQVIPQDDNWGDNTTAITGNTSETGFSMEELDKFAVRDNDRQVGVNCARYVGTALTVGLSVIAFLSPIAMVLLPKLDIMDWRASSMSPEDSECRPECEGLLISFAFKLLVLLVGAVALFFRKPRATMPRVFVFRAVVLFLVFVLTFAFWLFYGVRIFKEKQGTYEGIVQFALSLVDSLLFVHYIAIILLEIRQLQPQFAVHVVRSPDGESRVYNVGLLSIQRAAVHILEQYYRDFQMYNPYLENVTKKHSKHPSTAFKVYDIDGSAPNQQANQNRARNVFPAAPRGRREQGHNDRFHDEQEYERRVRKRRARLVVATEEAFTHIKRMHDEQGPAISMDPGEAAAAVFPSLARALQKYLRITRQQPRYTMDSVLSHLATCISHDMSPKAFVARYLSQGAVVCGNPQEVGSTERWLLVCEQLLTRELDHRMVFQLKKGPVALLCTVAKIPHFSLTEEMLHPKANKFVLRLNSETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JTG8</accession>
    <name>A0ABM0JTG8_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase D-interacting substrate of 220 kDa B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC101848825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005101087.2">
        <property type="nucleotide sequence ID" value="XM_005101030.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848825"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057092">
        <property type="entry name" value="SAM_KIDINS220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF0">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23307">
        <property type="entry name" value="SAM_KIDINS220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="4">
        <location>
            <begin position="441"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Kinase D-interacting substrate of 220 kDa-like SAM" evidence="5">
        <location>
            <begin position="1202"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1307"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1381"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1450"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1604"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1731"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1811"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1318"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1382"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1399"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1419"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1493"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1604"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1636"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1647"/>
            <end position="1663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_005101087.2"/>
        </source>
    </evidence>
    <sequence length="1833" mass="200981" checksum="AB46B1150B3E0A06" modified="2025-10-08" version="1">MSSFKAQLLWDNISRGDLSAVHTMLESANVNLEERDANGCTFLMVASEQGAVNIVRELLQAGVDPTAVDNENWNALLCASKEGHLEIVMELLEMNVDLEHTDMCGWTALMWACYRGNTLVVSELLERGANPNVKADHHMTCLSWAAGRGYTEVVKLLIDKGAKVNMPDKYGTTALIWACRRGHLDIVDALLGEGVAVDASGMNSWTPLLVATKGGHFDVVRSVLSMDPNVNATDKDGLTALAIAAKDGYAEVVNDLLRKGAYVNLVDRNGDSILIHAVKGGYIEIVKALLKKYVDVDVPGQEGKTAIYCAVEKGYTEIVKLLLNSNPDLELSTKDEDTPLLRAVRMRNEECVRLLIDRGAKVSASDKRGDTALHIAIRARAKRITELLLCNPRHSRLLYRLNKAGESPYSMDTYYQRGILPQIYGHGKLNATDAENLLGYEIYSSALADILSEPGLMTPITMGLYAKWGSGKSFLLDKLRVEMRSFTQQNSQGELNWSWLTAFLFLLLNTMLGEVLGLTLGWRVGLAVGLGLLPLQYAFIGIIIFFTVKHDFSLTNRISAALARKQKLLALFMQMLFCVPKQRPVSDKHSMASSFSVRFLFSDCTRLTSVGGEKSLAAMIGTLCEAVEKEYGVFIARLFRVFKPTPGKSRSSRFKSICCVPYFIIFLLLLICVQVGVGLAVAFGIKESVAVDAVLIALVSVVGLALVTNLYTWGQMLVALVFSQKKRVIRAADSIDELKMDGFMQQLKTEVDLMSRMVNCLDSFTQDQTRLVVIVDGLDSCEQDKVLQVLDTVKSLFSDEGAPFITILAVDPHIIIKGIEQNLRSSFQDSNVNGFDYLRNVVHLPFYLQSQGMRIQQVEPVPSHQGAGESPSKATRQDSTLTNASETRVGLRKASRNLSTSVAGGSLSDSVPGTIYASSYDLTSSAAKNDYFSDINPRSMRRLMNIVAVTARLLRAYNIDFKWHRLAAWINLTEQWPYRLSWIIYHFEEAEVMENSASLYSLYKRIVPSIPATKEQDPLLEIDRNVRKLEASLTSKSGNFPLLSVADLKKFLPCTINLDPYLRKLIRENQHNLERQQAEIATLGGVFPPPQPPPAPMLGSRLREQAASERVALLSSPVRFGAPLTPAGMLYGMYGAQPQVSYAAALAAAAAMQQQQQNPQGMPQFFSPGAAQNGMRMPGADQRKVVDSAVKHPNEFFMNYSQPVVLSQCSVQEVCDLLSRLRGLSPSLLSEYQASVRENNISGLVLAMCDLSELQPILAMRFGDWQLFRSAVSSLLNFENEDVPSGPGEDISSASSLLASKTGPVSMSSSVNSYSTAPGGGGGGRGSLPGRSMSLQEPVGGSRTTGKSELQRIQERKFKRNDSIVQQLSYETAILKSAVSEFVEESEEEEEEDEEEIEAEKRPGVENRRKEEEEEEEEGSLRKSEDKEARSPEARARFKLGQEYLEDIPSLAVHTHGTNSMKDKQIHSSASHPGKNEKLLEHLPTGTVSGGDEVSRHQESDPSRDSPRHSGTFTLSGAENPVSLHDISPYIKVLDGPMGRTTPHGSGEFVPLLGSIQLHSSHSSNEFVPVSQHSSLSQIPEIGATGSNTSSNLLLSTATTSSENSLSQAASSQTSFTSQKSSQPSSGPQQQPFAEASSTKSTALARQQAISQSGMSQQGSSESPTKEFHFSSVDPHLDVSPLITPTEGEPAECADLVPDSQDHHRPRGPLHTLSSSIERLARPVLGHFNRHHHHQQHHNVEHPPENSSTQEACLEEGRAGDVSVAGHPRRALDHEDLFQRSFTTIVEMSSPQTDAGTDDFHHRLGVAFANVDGVEDEPAASSRKSSQDRETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUL1</accession>
    <name>A0ABM0JUL1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">von Willebrand factor D and EGF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC101848666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101855.2">
        <property type="nucleotide sequence ID" value="XM_005101798.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101848666"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF54">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_005101855.2"/>
        </source>
    </evidence>
    <sequence length="149" mass="16419" checksum="CCE8F769E0DE952F" modified="2025-10-08" version="1">MCQCKTGYEGKHCETPTCNPPCLNGGTCLSPGRCHCQSGYQGKHCERALCHPACKHGGVCRRFNTSVCRPACMNGGRCVGPNTCLCSSGWTGHRCDQPLCYLQCRNGGLCVNPNVCACPRGFIGPDCGRRIRTHQVPRYWRRRFSYGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JUN3</accession>
    <name>A0ABM0JUN3_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC101860262</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005101905.1">
        <property type="nucleotide sequence ID" value="XM_005101848.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860262"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="9">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005101905.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="49954" checksum="E087C047A00D9C8C" modified="2025-10-08" version="1">MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSSTFIGNSTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFDEEEEDGEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JV54</accession>
    <name>A0ABM0JV54_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC101861055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005102245.1">
        <property type="nucleotide sequence ID" value="XM_005102188.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101861055"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005102245.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="60611" checksum="99D69DD8F972FA9E" modified="2025-10-08" version="1">MASGMPIIVLNQNTKRESGRKVQIGNIDAGKTVADIIRTCLGPRSMLKMLMDPMGGIVMTNDGNAILRELNVQHPAAKSMIEVARTQDEETGDGTKSVIILAGEVLSVAEQFIRQQMHPTIIIAAYRQSLEDILEELKNKVAVPVDVTNKEEMMKIVKSCLGTKFISKWMDLACQIALDATSTVVVEENGKKEIDIKRYAKVEKIPGGLLEDSKVLKGVMINKDVTHPKMRRRIENPRILLLDCNLEYKKGESVTNIEISQEQDFSKILKLEEEYIEKICKEIIAFKPDLVITEKGVSDLAQHYLVKANISVIRRVRKSDNNRIARACGATIANRTDELREEDIGTGCGLFEVDKIGDEYFTFLTECKNPKACTILLRGASKDVLMEVERNLQDAMNVARNVLIDPYLVPGGGAAEMALAQALNEKAKSITGVHQWPYRAISRALEVIPRTLIQNCGASTIRTLTALRAKHAQPNNSTWGIDGNTGTLVDMKTFGVWEPVSVKQQVYKTAVETAILLLRIDDIVSGVKKQGADGGGAPSGPPPQASEGPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWE3</accession>
    <name>A0ABM0JWE3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein Rab-39B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101856746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103100.1">
        <property type="nucleotide sequence ID" value="XM_005103043.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101856746"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005103100.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24619" checksum="C0BF963F5002AAE5" modified="2025-10-08" version="1">MCDPIFEYQFRLILIGDSTVGKSSLLRYFTDGKFDEACDPTVGVDFYARLMEVKPGVRVKLQLWDTAGQERFRSITRSYYRNSVGVMIVYDISKRSSFENLKDWYEEAREHIEPHKAIFVILGHKADNDEKRQVTFREGKRFAEMHGLKFFETSAKTGQNVEESFAQIAKDTYQHLQDGHIKIEEGWDGVKVGFARPKETVHLAEAEGESRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JWR1</accession>
    <name>A0ABM0JWR1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBL-interacting protein kinase 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC101853633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_005103341.1">
        <property type="nucleotide sequence ID" value="XM_005103284.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101853633"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005103341.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31193" checksum="BF188E40E70511E6" modified="2025-10-08" version="1">MSSVEQISVIQLPKEVDVFHYHRMQYSSVLHQGQRSKILLARSQIIPDKKFAVKQMPLRSDEDRDRFSREMWLMKLASDIRGVVTLLPRPVFCGPTGYLIMPFYDKRDLLSRTGKLSDDNWMKVFVRAAVSLRSLHKKNIYHQNLRPENILLSTRHVAFISDFGAACLLSEGCDKVDTWTAAPGFRGPEADKEDGQLCPFQLDTYSLAVSMWQVLSGLCPVKNKPLDHLDNIPPQYASLLRNLLLPDPDMRWTLDKFLTEALELQPDLSCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXN6</accession>
    <name>A0ABM0JXN6_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein MIX23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Coiled-coil domain-containing protein 58</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC101860187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005103959.1">
        <property type="nucleotide sequence ID" value="XM_005103902.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012941123.1">
        <property type="nucleotide sequence ID" value="XM_013085669.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101860187"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_005103959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_012941123.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17715" checksum="77FFC67D87978616" modified="2025-10-08" version="1">MAAPNGQQYLPCDDFLKFQDSLKKLRLIDDRIIHALNTKIPTQSFRHKVDVNSECKRLYDEMQVSYDQRDKSIRHCLELVSNDVKQLRQKKMDSPDDVNVLRELRKEQTKLRLMQQEMSIEEVVKDRTLKVFYERCRDNYTPPAAPIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JXS1</accession>
    <name>A0ABM0JXS1_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein DGCR6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC101857425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gonadal family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104030.1">
        <property type="nucleotide sequence ID" value="XM_005103973.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101857425"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010849">
        <property type="entry name" value="Gonadal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054">
        <property type="entry name" value="DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054:SF2">
        <property type="entry name" value="PROTEIN DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07324">
        <property type="entry name" value="DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_005104030.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22497" checksum="4374B5BDFEFC6490" modified="2025-10-08" version="1">MNEDQSSKEELQKRHYVLLNELQNMARELPGKFQQRLPYDLLSSLAKALLDGTAFEIVKGLEEVQHLEEKSLFTQRLKMINDHKSQRHEMKKKHKELLMANQNKPHNLPLLVSQVERERETQERRFEEEMKRRDVKIILELDQKLMDQQSMLEKAGVPGFYVTNNRHDVRLQMYLLEFIVRLAAEDQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYH0</accession>
    <name>A0ABM0JYH0_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Adhesion G protein-coupled receptor A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC101847129</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104508.2">
        <property type="nucleotide sequence ID" value="XM_005104451.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101847129"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058808">
        <property type="entry name" value="GAIN_ADGRA2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF4">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26588">
        <property type="entry name" value="GAIN_ADGRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045905145" evidence="14">
        <location>
            <begin position="28"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="848"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="916"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="966"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1114"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1145"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="226"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="16">
        <location>
            <begin position="312"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="15">
        <location>
            <begin position="690"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="17">
        <location>
            <begin position="845"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="626"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1053"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1203"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1290"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1393"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1522"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1572"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="1065"/>
            <end position="1078"/>
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        <location>
            <begin position="1304"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1397"/>
            <end position="1407"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1472"/>
            <end position="1484"/>
        </location>
    </feature>
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        <location>
            <begin position="1485"/>
            <end position="1498"/>
        </location>
    </feature>
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            <begin position="1582"/>
            <end position="1607"/>
        </location>
    </feature>
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            <begin position="1696"/>
            <end position="1713"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1721"/>
            <end position="1732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
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    </evidence>
    <evidence type="ECO:0000259" key="15">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_005104508.2"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0JYZ3</accession>
    <name>A0ABM0JYZ3_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UPF0415 protein C7orf25 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC101861145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0415 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_005104830.2">
        <property type="nucleotide sequence ID" value="XM_005104773.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101861145"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010733">
        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041076">
        <property type="entry name" value="DUF5614"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18474">
        <property type="entry name" value="DUF5614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5614" evidence="4">
        <location>
            <begin position="12"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1308" evidence="3">
        <location>
            <begin position="396"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_005104830.2"/>
        </source>
    </evidence>
    <sequence length="576" mass="62306" checksum="847041A00674FF0A" modified="2025-10-08" version="1">MKRFAMEERPEGVLVDVVAGGGYMWVKVIARKAEALHCVWAGQGQFGERDLTVQAGEYLQCAHSHPHNFTTPQVHFAFYNNVTEPMAEALTDMGVTVWGRRVPVRPELQQKLALHLAHLDDDDDDEEDYDHNEDDDDHEDDDDDKDNDDEDREEEDEEEDEEDSGINPPYETEQLSAATSGKEKNLPNPTGGCIEPCARTESTPTITDDSPCLFDICPEKYVLGGTISSVYCDDIDDIRERISTMVEDSAPSHSVSTPEHAPSTQVDGVEEPSPGPVVALGESLLGGSSPSLQKNSRDSIPPESSPLPACTIGDLRPLTDAIVTLCPSRSSVGGGCSGGVAEQQRGISQQGSDSQLGKVNIVFQCLVVSPPDFSPGHCPSMSQPPVSQGLTTVSKVNLDITCMIALVSALTHGGCHTEFREKVLRRQAEEERREPVLPALQTFLQGKELYASESAATCFRDLVSLMGGPGEKTRADQLLSTVRVVADQPSARARGLSCGGKVKDRSKVIFGTGDSLEAITVTSNMGFVRAAQNQGVVFPAFLHSARALTEQKERQEPSTRNLGLSARRNGADCDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K001</accession>
    <name>A0ABM0K001_APLCA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC101863047</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="RefSeq" id="XP_005105530.1">
        <property type="nucleotide sequence ID" value="XM_005105473.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_005105531.1">
        <property type="nucleotide sequence ID" value="XM_005105474.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101863047"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16574">
        <property type="entry name" value="RING-HC_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058745">
        <property type="entry name" value="PWI_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058746">
        <property type="entry name" value="Znf_RING-type_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26084">
        <property type="entry name" value="PWI_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="736"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1214"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1287"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1343"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1512"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1214"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1302"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1343"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_005105530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_005105531.1"/>
        </source>
    </evidence>
    <sequence length="1610" mass="172348" checksum="3E9DC826F9E6B7D5" modified="2025-10-08" version="1">MPVTRNQSNAAAAQARTGNEAGEGSSSKNEAAGGEGEGSGEGDASRRDSPDNCSICLGPFNNKSFTSSCAHSFCFVCLKQWSKVKAECPLCKQPFTSIFHNIRSNQSYDIYDLPLNPTRQPEYNNFLSYGSFASANPFPFFMPGPSLDADLTLSNFSRFQFRHRRSFHPSSINAEHQYSFQTPLVSPATHVSAATWPRGADDFRREVYRRYLGPPAVVLGTENSNYILTPAMVNASAHRLHRIMPWLTRELRVLVRSHQNVRSAIGIIQPLLTQVMIDSQCFRERVAPYIGHKSQQFIQEFVAFANSAMNVQTYDRKAMYRRRDHTTITFESSSNSSTDDDVVEVTDISPETPSASSTAPPPPPVATRPVPTLSNLLQSSGWDSPTPGPSWESVVTSTQPAGTQEDRVSVSSEGEDAVFVPALHASDSDDSKAGSDIVFVKYDKPWNERSPINLSSDSDGEDGPKVKKKKKSKHKKKRMPSLGSDAEVSKTEKGHKASKSKSKSRDKSVPTSRASGEELEQETSSGVSVSKRRLSASSVDRQKAKKHRKSKDRRDRHSGHDRDRELVDKLFAEAILGGAQPGVSTDADKPSKSSEKSKKKKKHKSRRQEDRSPLHLQTYKKHPSGHKKSTDPKRSGRNPGSHNSGDRGRSRHRSGCAEGDEVSSVSETPLSSSQRGGAYSRDTAVPLNPPQLSSSGFSHSVSSSFQAPYMPMPDTVQHIPLNLWVSTWPSLPVSHTYPPPPPAPQGLCTSPPHNANASSSLAGPSRPAGDSHTISSDSSSDSDDSDDTQDYQDASTESSSSHTQQWIEKNFPCIGASSSQSASATATSSSVATAPTVAQADTCAQSNVAAAQASLNGGQAHNTVLDKSDESLNVDVLSVPSDDEDEDVVICSSASSDNSDNDEDVKVVDVEEGATATVHPNPLSSAATAFVTSFSPQSLAQTSASHPVSMESVYTPQACTSRSASASSRSTSASREVGRFRPFRLYRKNAPTKQPFDRFFPPIGPSSEDESEDFLLRGSSPSSSSAAEQLSSRDSEQKDETVTSGNEPGQILANAVSVSSTVISSVSSPVASTVLSGSPALSSGNFQPSSSSSPQKNASCIEADVDTPRYAQVFTTSESRNTLFSVLPPLQAPNPPPVTSVLSSRLSYLPFSGMQVSSSLSSIMTPALPYRVPQPPPPPPLPIHFPFPPFPPSLPTLSSVLSPLYPALTQTSASTGTTLSTVSKQDHSTIPEAATRTSGDFGEFTATPATIGEETAPASCQPVVSVAEKSSIWNTDGGLFNILAHSESNGNEGAGPGTDALARTRESSRWEDGQDCRPSVASSSRIPVEENEKCVVFDALESTTNGSSPPGSWSVSQMLPSGGDGEADEVDDLNDTGSSVPLMIDEKYEASDLSLNTSSHLSEVNSLGDCQTDGTSKRFAAHEDTADRVLNGNNSCSAPKAVPTDDHIWSSKVPQSVRRAKCSLSSYASHNADQQVENIWDSTSGGTETMANGKEPVELFQSSDALYAPQQLSNEDGRESVGSAAGNHNPTDSYPLHIATDQLGDQHEEHELVDFDRPQSCSEVHNLSLGISDNSLQSLGESSSVLDHSGQTVPQFRDALVSPDVTDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM0K213</accession>
    <name>A0ABM0K213_APLCA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cholesterol 25-hydroxylase isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC101858806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aplysia californica</name>
        <name type="common">California sea hare</name>
        <dbReference type="NCBI Taxonomy" id="6500"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Tectipleura</taxon>
            <taxon>Aplysiida</taxon>
            <taxon>Aplysioidea</taxon>
            <taxon>Aplysiidae</taxon>
            <taxon>Aplysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_005106894.1">
        <property type="nucleotide sequence ID" value="XM_005106837.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101858806"/>
    <dbReference type="Proteomes" id="UP000694888">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evi
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